Dual-Comb Ghost Imaging with Transformer-Based Reconstruction for Optical Fiber Endomicroscopy

David Dang, Myoung-Gyun Suh, Maodong Gao, ByoungJun Park, Beyonce Hu, Yucheng Jin, Wilton Kort-Kamp, Ho Lee

Advances in Neural Information Processing Systems 38 (NeurIPS 2025) Main Conference Track

Endoscopic imaging is indispensable for visualizing internal organs, yet conventional systems remain bulky and costly because they rely on large, multi-element optics, which limits their ability to access and image certain areas of the body. Achieving high-quality endomicroscopy with hundred micron-scale and inexpensive hardware remains a grand challenge. Optical fibers offer a sub-millimeter-scale imaging conduit that could meet this need, but existing fiber-based approaches typically require either raster scanning or multicore bundles, which limit resolution and speed of imaging. In this work, we overcome these limitations by combining dual-comb interferometry with optical ghost imaging and advanced algorithm. Optical frequency combs enable precise and parallel speckle illumination via wavelength-division multiplexing through a single-core fiber, while our dual-comb compressive ghost imaging approach enables snapshot detection of bucket-sum signals using a single-pixel detector, eliminating the need for both spatial and spectral scanning. To reconstruct images from these highly compressed measurements, we introduce Optical Ghost-GPT, a transformer-based image reconstruction model that enables fast, high-fidelity recovery at low sampling rates. Our dual-comb ghost imaging approach, combined with the novel algorithm, outperforms classical ghost imaging techniques in both speed and accuracy, enabling real-time, high-resolution endoscopic imaging with a significantly reduced device footprint. This advancement paves the way for non-invasive, high-resolution, low-cost endomicroscopy and other sensing applications constrained by hardware size and complexity.