objectiveto investigate differences pressure pain sensitivity maps patients migraine healthy controls considering episodic chronic side strictly unilateral bilateral symptoms seems trigeminal area sensitized migraine study investigated pressure sensitivity maps patients migraine pain thresholds assessed points distributed patients episodic migraine chronic migraine healthy age matched healthy controls blinded design pressure pain sensitivity maps based interpolation constructed clinical features migraine anxiety depression hospital anxiety depression scale collected resultsthe multivariate revealed significant differences points anterior posterior gradient found lowest located frontal regions highest occipital areas groups found patients migraine exhibited generalized pressure pain hypersensitivity head compared healthy controls hypersensitivity similar episodic chronic unilateral bilateral migraine pressure pain sensitivity maps revealed anterior posterior gradient pressure pain sensitivity migraine control groups
objective paper explore bim building information modeling applications sustainable infrastructures response global warming shortage energy resources challenges environmental degradation humans trying build low carbon eco cities low carbon green buildings building green refers entire life cycle building includes maximizing conservation resources energy water land materials protecting environment reducing pollution providing people healthy comfortable efficient use space establishing nature architecture field green sustainable buildings bim integrated analog energy buildings air flow analysis buildings ecosystems using bim possible reduce waste improve construction quality bim builds visualization digital building models multi dimensional digital design solutions provide simulation analysis scientific collaboration platforms designers architects utilities engineers developers even end users moreover bim helps take advantage three dimensional digital models design construction projects operational management authors published elsevier
todays power system network become complex responsibilities challenges provide secure reliable quality energy supply communities small entity electrical network known microgrid popular nowadays enhance secure level energy supply case energy crisis utility network also provide clean energy supply integrating renewable energy sources effectively small scale solar photovoltaic power system suitable provide reliable clean energy supply remote urban communities residential level paper presents basic analysis study stand alone solar photovoltaic power system developed aid matlab simulink software basis residential load profile solar exposure level particular area state simulation result control behavior power system optimum sizing battery storage facility daily energy needs residential load level study provides good platform develop effective reliable stand alone power system remote communities near future
recent years considerable effort devoted enhancement distributed hash table systems capabilities systems typically provide individual node routing broadcast primitive required functionalities information dissemination data aggregation also used basis partial keyword searches little work however specifically addressed known used real applications work system notably based distance metrics analytically studies techniques applied model estimates node coverage function probability individual messages reach destination also developed validation several algorithms implemented comprehensively evaluated considering node coverage messages nodes ratio latency imbalance factor moreover several techniques proposed enhance bare protocols adverse circumstances failure rate conditions present include redundancy flooding also combinations implemented fully tested analysis strengths weaknesses algorithms additional techniques discussion choices make depending system characteristics application priorities finally presented
background mapping disease rates region provides visual illustration underlying geographical variation disease useful generate new hypotheses disease aetiology however methods fit popular widely used conditional autoregressive car models disease mapping feasible many applications due memory constraints particularly sample size large propose new algorithm fit car model accommodate individual group level covariates adjusting spatial correlation disease rates termed method scales works large datasets methods fail results evaluate performance method simulation studies simulation results indicate provides reliable estimates regression random effect parameters also apply analysis data neutropenia admissions new south australia analyses reveal lower rates neutropenia admissions significantly associated individual level predictors including higher age male gender residence outer regional area group level predictor social disadvantage socio economic index areas large value spatial dependence parameter estimated adjusting individual area level covariates suggests presence important variation management cancer patients across conclusions incorporating individual data disease mapping studies improves estimation fixed random effect parameters utilizing information multiple sources health registries routinely collect individual area level information thus benefit using mapping disease rates moreover natural applicability distributed computing framework enhances application big data domain large number individual group level covariates study reference number july
review shows water biological systems just passive liquid solvent also partner formation structure proteins nucleic acids complexes thereby contributing stability flexibility required proper function biological affect state water partly normal liquid state somewhat ordered bound proteins results reluctance hydrophobic groups interact water collagen maintained water forming controlled frame around coil dna stability rigidity linked water fixed pairs minor leads contribution pairs exceeding pairs greater entropy contribution result pairs melt lower temperatures loss water drives transcription factor binding minor
auxiliary equation method presents wide applicability handling nonlinear wave equations article establish new exact travelling wave solutions nonlinear equation coupled equation equal width wave equation travelling wave solutions expressed hyperbolic functions trigonometric functions rational functions shown proposed method provides powerful mathematical tool solving nonlinear wave equations mathematical physics engineering throughout article calculations made aid maple packet program
anti antibodies used convenient tools exploration functional mechanisms treatment overexpressing tumors employed yeast express anti single chain antibody derived tumor inhibitory monoclonal antibody yield exceed cultures considered poor codon usage bias one limiting factor leading inefficient translation production designed synthesized full length gene choosing preferred keeping content relatively low level codon optimization increased expression level fold northern blotting confirmed increase expression mainly due enhancement translation efficiency investigation culture conditions revealed maximal cell growth expression achieved acids methanol induction secreted easily purified homogeneous product culture supernatants one step using affinity chromatography yield approximately functional studies showed internalized high efficiency binding overexpressing cells suggesting prove especially useful targeted immunotherapy elsevier inc rights reserved
objective study identify characteristics lesions using whole spine magnetic resonance imaging mri compared plain radiography ankylosing spondylitis total patients undergone whole spine mri plain radiography retrospectively enrolled study compared number units lesions clinical radiographic indices erythrocyte sediment rate esr reactive protein crp bath ankylosing spondylitis disease activity index basdai bath ankylosing spondylitis functional index modified ankylosing spondylitis spine score fifty three patients whole spine mri patients plain radiography least one lesion found lesions mri plain radiography spine levels lesions mri commonly detected lower thoracic spine among total lesions whole spine mri identified central disc type anterior peripheral disc type posterior peripheral disc type diffuse disc type however number lesions correlate esr crp basdai study indicates presence lesions patients clearly underestimated mri superior technique detecting early lesions compared plain radiography
early engineers heavily achievements past employment county involved restoration existing works however engineers often existing environment involved destruction tower london abundant examples showing scant concern heritage passed contrast engineers like used engineering skills extend life threatened structures frequent debate seeking improve existing infrastructure want improvements take account historic engineering heritage recent examples include strengthening tunnel network improvement works heritage successes often based committed individuals using engineering knowledge mount successful campaigns despite powerful analytical tools ever improving monitoring technology structures like internationally significant union suspension bridge threat argue comes money part result engineers education lack knowledge heritage sense place
aims compare efficacy safety low dose standard dose infliximab induction maintenance treatment chinese patients intestinal disease identify potential predictors corticosteroid free clinical remission week methods prospective trial conducted patients moderate severe active intestinal followed weeks examinations done baseline week logistic regression model used assess predictors corticosteroid free remission week results primary end point steroid free remission week observed patients received low standard doses respectively secondary end point mucosal healing rates week found low standard doses clinical response rates week also similar groups week predicted steroid free clinical remission week conclusions low dose effective safe induction maintenance therapy patients active intestinal week predicted clinical remission week
background objectives young people social anxiety display poor social functioning unclear whether difficulties key social cognitive abilities perspective taking examined whether increased social anxiety associated reduced accuracy perspective taking task whether relationship stronger particular periods within adolescence methods fifty nine adolescents aged years completed task social anxiety scale adolescence participants virtually move objects following either instructions given see objects simple rule ignore certain objects results participants scored clinical cut social anxiety less accurate take perspective account scoring cut yet performed similarly control trials preliminary analysis indicated poorer performance strongly associated social anxiety mid adolescence years limitations used previously measure online perspective taking underlying cognitive mechanisms fully elucidated extending findings using additional measures perspective taking valuable conclusions adolescents higher social anxiety less accurate taking perspective character suggestion relationship strongest mid adolescence replicated findings highlight importance addressing specific social cognitive abilities assessment treatment adolescent social anxiety published elsevier ltd
remains conflict literature affective face perception studies reported right hemisphere advantage irrespective valence whereas others found left hemisphere advantage positive right hemisphere advantage negative emotion differences injury aetiology proportion male participants participant age number emotions used within perception task contribute contradictory findings present study therefore controlled directly examined influence possible moderators right brain damaged left brain damaged healthy control participants completed two face perception tasks identification discrimination group differences facial expression perception according valence found across emotions group less accurate group however group performance differ lack difference groups indicates involved positive negative expression perception inclusion older adults defined range brain damaged participants moderated findings participant sex general face perception ability influence performance furthermore group less accurate led group identification task tested two emotions performance two groups indistinguishable number emotions increased four six suggests task demand studys ability find differences perception facial emotion elsevier inc rights reserved
objective potassium channels atp sensitive family atp channel inhibited increase intracellular atp electrophysiological studies demonstrated kinetics pharmacological properties channels vary among different tissues suggesting structurally functionally distinct types studies showing human periodontal ligament cells respond mechanical stress increasing atp release participates bone resorption bone homeostasis study investigated existence channel subunit single channel properties human periodontal materials method human cells isolated healthy third molar patch clamp experiments human fibroblasts plastic inside patch clamp recordings performed voltage clamp mode reverse transcriptase polymerase chain reaction pcr conducted identify channel subunits pair wise comparisons performed paired test value considered significant results observed mrna transcripts human cells inside patch mode single channel conductance symmetrical concentration seen atp free bath solution reversal potential currents found symmetrical concentration bath solution single channel currents almost blocked adding atp bath solution however currents blocked subunit specific atp channel blocker conclusions results indicate human cells express atp channels subunit including sensitive atp insensitive elsevier ltd rights reserved
world south africa generated extensive controversy use african asked white american participants opinions attitudes towards variety racial ethnic minority groups including immigrants african americans found less participants less positively also tended feel toward minority groups furthermore respondents least also less generally open change findings suggest controversy just plastic also episode differential ingroup outgroup perceptions lack openness new things
forces acting single drag important parameters machine design selection better prediction tool forces including cutting normal forces generally general model cutting forces proposed based theoretical models also general model normal forces proposed using ratio normal force cutting force subsequently effect relevant geometrical parameters cutting force discussed friction angle rock cone angle attack angle employed develop cutting force models angle friction angle rock included peak cutting force model radial finally peak mean cutting forces models peak cutting force model radial cutting mode developed using principle component regression analysis regression analysis based raw data linear full scale cutting test results show proposed regression coefficients equations reasonable physically empirical models used practical application developed introducing relevant modified coefficients considering tool wear cutting complex shapes results show good agreement measured predicted cutting force sharp cutting mode performance modified models using relevant modified coefficients decreased certain extent however statistical valid according results test models work used estimation tool forces acting drag elsevier ltd rights reserved
paper presents concept software defined radio flexible front end design architecture system possible application examples explained one specific scenario operation frequency bands known service automatic identification system captured mission chosen application example results embedded solution platform presented paper since increasing request performance radio bands services like enhanced international association marine aids navigation authorities new data exchange service implement dedicated satellite link paper describes flexible front end used technology demonstration platform upcoming data exchange service
work addresses problem design optimization compact microwave structures particularly impedance matching transformers approach proposed exploits structure decomposition bottom technique elementary building blocks transformer circuit interest first optimized respect specifications extracted conventional circuit design subsequently entire circuit optimized using previously obtained building block dimensions starting point optimization engine stage process based gradient search embedded trust region framework bottom approach turns critical reliability initial dimensions obtained optimized building blocks already result reasonably good characteristics entire circuit global search required find satisfactory design contrast direct based optimization entire circuit leads local optimum satisfy imposed requirements time computational cost design process reduced compared direct optimization entire circuit building block optimization carried low dimensional search spaces using simpler less expensive electromagnetic models technique demonstrated using three section impedance matching transformer copyright john wiley sons ltd
present study investigated profile based perspective six dimensions character strengths heart strengths heart self focused strengths heart others focused strengths mind strengths mind self focused strengths mind others focused strengths aim identifying optimal combination character strengths second aim examine whether profile membership associated mental health markers predicted least two qualitatively distinct profiles emerge heart strengths profile mind strengths profile also predicted heart strengths profile strongly associated markers mental health mind strengths profile respondents age years completed measures assessing endorsement character strengths range mental health markers latent profile analysis identified optimal profile solution based six dimensions strengths emergent profiles profile low strengths profile mind strengths profile heart strengths profile high strengths expected profile membership significantly associated mental health markers notably strengths heart hope contributed favorable presentations therefore strengths associated heart dimension enhance mental health elsevier ltd rights reserved
background number dysregulated mirnas identified proposed significant roles pathogenesis type diabetes mellitus renal pathology shown significant anti inflammatory properties play anti diabetes role objective study detect alteration mirnas underlying anti diabetes effects extract type diabetic animal model results treatment weeks led lower concentrations blood glucose urine albumin urine creatinine mirnas statistically identified differentially regulated mice respectively compared untreated mice mirnas identified comparison groups mirnas verified quantitative real time pcr functional bioinformatics showed putative target genes mirnas associated several diabetes effects signaling pathways conclusions suggest potential medicinal anti diabetes treatment changes expressions specific mirnas results provide useful resource future investigation role regulated mirnas diabetes mellitus
paper thermal performance textile samples technique amplitude signal presented special case signal relative empty sensor implemented order avoid experimental factor simplify final expression voltage addition simulated fault detector based microcontroller order provide low cost protection lock amplifier obtained thermal parameters single fabrics made cotton cotton fibre fibre measured fitting theoretical curves experimental ones amplitude signal according modulation frequency root measurements good agreement corresponding values extracted phase signal reported literature values
background even though united nation persons mental illness treated respect inherent human now use physical still considered unavoidable managing abnormal behavior psychiatric patients information regarding magnitude contributing factors physical among bipolar patients low income countries like ethiopia methods cross sectional study conducted mental specialized hospital june among participants selected systematic random sampling technique data collected interviewing adjusted odd ratios aor confidence intervals used value considered statistically significant results prevalence physical factors like two episodes aor history aggression aor comorbid illness aor use antipsychotic aor current use aor associated significantly conclusions prevalence physical restraint found high among bipolar patients needs public health attention
amongst side effects substantial percentage patients experience injection site pain underlying mechanism unknown found dose range induced complex dose dependent mechanical male rats distinct peaks contrast females broad peak highest dose produce either sex evaluated receptors mediating males injection antagonist serotonin receptor subtype markedly inhibited induced receptor antagonist completely eliminated contrast females receptor antagonist completely blocked receptor antagonists attenuated females estrogen receptor dependent selective agonists produce robust female male rats respectively injected induced sexes attenuated mechanical induced dependent protein alpha subunit protein kinase positive negative understanding mechanisms responsible complex dose dependence provide useful information design anti migraine drugs improved therapeutic profiles ibro published elsevier ltd rights reserved
study examines rates morbid mental disorders indicators course illness among individuals bipolar disorder cannabis use disorders data drawn national epidemiological survey alcohol related conditions wave nationally representative sample adults living united states among individuals lifetime prevalence bipolar disorder rates past months compared general population logistic regression models adjusting sociodemographic variables indicated individuals bipolar disorder occurring increased risk nicotine dependence adjusted odds ratio aor alcohol aor drug aor use disorders antisocial personality disorder aor compared without among individuals occurring age onset bipolar disorder significantly lower median number manic depressive episodes per year significantly greater compared individuals without occurring associated significant morbidities severe course illness among individuals bipolar disorder comprehensive evaluation patients bipolar disorder include systematic assessment elsevier ireland ltd rights reserved
many mental health care potentially affects engagement recovery processes health outcomes article introduces tool assess fear adverse mental health treatment experiences clients perspective sample adults receiving mental health services community agencies study initial exploration validity scale assessing associated commonly experienced interventions factor analyses supported construct validity item fear adverse treatment experiences scale significantly based upon service characteristics gender history victimization past experiences interventions higher levels fear reported users traditional mental health services former inpatients voluntary admission status changed males people history childhood abuse people certain forms criminal justice involvement
decomposed difficult losing vegetation cover developed new drilling machine efficiently six holes simultaneously decomposed facilitate consists base machine level mounting body six hydraulic motors instead tested performance two southwest korea using time motion studies showed decomposed daily unit cost less half stabilization techniques korea making cost effective technology field growth tests also conducted identify appropriate diameter depth drilling holes suitable species treatment holes three different diameters depths filled holes mixture plant seeds cultivated soil applied treatments geotextile net measured growth results two field plots results showed drilling diameter depth large enough result better plant growth erosion control species survived grew better native species geotextile improved plant growth time motion results show promising technology restore decomposed copyright john wiley sons ltd
wind tunnel study improvement aerodynamic stability simplified suspension bridge girder structures conducted using scaled section model objective study development economically superior suspension bridge center span length wind tunnel test showed edge girder type cross section exhibited large amplitude torsional vortex induced vibration torsional flutter low wind speed accordingly aerodynamic countermeasures open deck triangular structural countermeasures center stay mass increase tried improve aerodynamic stability finally feasibility best combination full scale bridge examined structural analysis higher education press
many researchers highlighted scarcity empirical studies systematically examine advantages disadvantages use visualization techniques software understanding activities studies crucial gathering analyzing objective evidence usefulness proposed visualization techniques tools ultimately guiding research software visualization paper presents controlled experiment aimed assessing impact graph based visualization technique comprehension tasks six common comprehension tasks performed undergraduate software engineering students completion time accuracy participants responses measured results indicate one hand use graph based visualization increases correctness average hand reduce completion time program comprehension tasks
present loss gain reconfigurable section analog signal processor asp dynamic radio analog signal processing asp asp provides real time tunable group delay response pass transmission propose lumped loss gain implementation tuning mostly easily achieved theoretical study derives transfer function fundamental characteristics device asp finally experimentally demonstrated first using single loss gain pair finally three cascaded loss gain pair structure full group delays shown illustration expected asp find wide applications asp systems requiring dynamic adaptability
pixel array sub detection pixel separately addressed integrated low cost cmos technology pixel comprises power detection circuit high gain operational amplifier efficiency self mixing analyzed improved detector operational amplifier sequential pulse generator used design row column signal producing circuit pixel array measured peak ghz ghz comparison pixel without load resistor also characterized measured results show pixel load resistor efficiently increase pixel output
physical model actuation system obtained closure model experimental models actuator friction characteristics proportional valves constructed variation discharge proportional valve shown ports taken care estimating two separate coefficients main flow path one leakage coefficient algebraic friction model retaining features existing differential model developed nonlinear subsystem models integrated together matlab simulink frame predict actuation dynamics variations predicted experimental displacements piston different command signals found quite close
studies found evidence playing violent min people experience mean short term increase aggression hostility anger current research investigated whether players longer realistic lengths play participants randomly assigned play game iii arena either min participants long condition showed smaller change state anger csa pre post short condition although reach significance change scores novice players showed short gaming led larger increase anger ratings long gaming results violent players analysed separately significant increase anger post length time playing results also supported hypotheses females show significantly larger csa males participants previously violent show significantly larger csa exposed participants
sodium water soluble derivative proven possess versatile biological properties pharmacological effect smooth muscle remains elusive paper presents study effect underlying mechanisms sodium mouse smooth muscle effect sodium evaluated mouse rings using mechanical recording system intracellular concentration measured primary cultured smooth muscle cells using confocal imaging system results showed sodium induced dose dependent relaxation mouse rings beta epithelium independent manner pretreatment atp sensitive channel blocker partly attenuated relaxation response administration sodium notably inhibited extracellular induced contraction high evoked elevation intracellular concentration also abrogated sodium smooth muscle cells conclusion effect sodium independent beta airway epithelium mediated primarily inhibition extracellular influx via type voltage dependent channels partially activation atp sensitive channel results indicate potential therapeutic value sodium asthma treatment
severity bronchial fundamental feature asthma severity varies associated lack asthma control mechanisms underlying trait still unclear study aimed identify genes associated severity using association study gwas slope adult methodswe performed gwas severity adult dutch asthma gwas cohort adjusting smoking inhaled corticosteroid use verified results three cohorts furthermore performed expression analyses lung tissue discovery cohort one significant hit located camp snps values found none findings replicated adult childhood replication cohorts jointly adult cohorts separately pituitary tumour transforming interacting protein like replicated minor alleles associated less severe higher lung tissue gene expression showed significant expression pituitary tumour transforming binding factor vimentin expressed significantly like involved notch signalling associated severity adult asthma relevance genes supported analyses expression vimentin
large scale initiatives expand evidence based practices often poorly implemented rarely purpose study identify perceived barriers facilitators evidence based supported employment program individual placement support within year prospective study among programs states participating national learning community interviewed team leaders coded responses semi structured interviews using conceptual framework adapted another large scale implementation study leaders agencies sustained programs identified funding prioritization workforce characteristics key facilitators barriers additional key factors lack local community supports barrier leadership structured workflow facilitators within learning community team leaders attributed program funding prioritization workforce agency leadership structured workflow actions learning leadership state governments local programs together contributed high rate
aims objectives explore sleep quality women examine factors contribute sleep disturbances intrauterine treatment background sleep disturbance important factor human health sleep disturbances tend occur among women intrauterine treatment although many studies focused high percentage somatic symptoms psychological distress women associated treatment studies investigated factors linked sleep disturbances design cross sectional study methods study conducted period september january teaching hospital taiwan women received assisted reproduction intrauterine treatment completed questionnaire demographic data somatic symptoms psychological distress perceived sleep quality collected results one third women reported sleep disturbances nausea symptoms psychological distress risk factors contributed sleep disturbance conclusions variables nausea psychological distress significantly explained sleep disturbances women evaluation nausea symptoms psychological distress among women important area future research research aim identify best compromise infertility treatment sleep quality relevance clinical practice clinical obstetrics nurses develop strategies help women reduce nausea symptoms psychological distress intrauterine treatment promote healthy sleep
project pet accelerator medical diagnosis treatment started university technology low level system accelerator designed stabilize acceleration voltage control resonance frequency cavity work intelligent low level radio frequency circuit suitable designed using beam monitoring device narrow band tunable band pass filter design phase detection need signal processing microcontroller
osteoporosis low bone strength low muscle mass strength impaired function often exist hence term osteoporosis similar health consequences regard disability falls fractures exercise adequate nutrition particularly regard vitamin calcium protein key lifestyle approaches simultaneously optimize bone muscle functional outcomes older people individually tailored appropriately prescribed terms type dose forms exercise equally effective optimizing musculoskeletal health regular walking alone little effect bone muscle traditional progressive resistance training effective improving muscle mass size strength mixed effects muscle function falls due common prescription slow controlled movement patterns present targeted multi modal programs incorporating traditional high velocity weight bearing impact exercises challenging balance mobility activities appear effective optimizing musculoskeletal health function reducing breaking time also help attenuate muscle loss also evidence support interaction exercise various nutritional factors particularly protein multi nutrient supplements muscle bone health elderly review summary provides overview latest evidence regard optimal type dose exercise role various nutritional factors preventing bone muscle loss improving functional capacity older people
paper dna algorithms proposed perform eight operations relational algebra calculus include product union set difference selection projection intersection join division relational databases
late life depression common emotional mental disability elderly population characterized presence depressed mood loss interest daily activities depression symptoms serious effect quality life elderly individuals increases risk developing physical mental diseases important area research given growing elderly population brain functional connectivity modifications represent one neurobiological biomarker even date remains poorly understood study enrolled elderly patients depressive symptoms compared age matched healthy controls participants evaluated means neuropsychological tests underwent functional magnetic resonance imaging fmri protocol evaluate modifications brain resting state functional connectivity group differences observed geriatric depression scale hamilton depression rating scale higher scores patients voxel wise way analysis variance revealed group differences left network sensory motor network increased intrinsic connectivity group observed left dorsolateral prefrontal cortex left superior parietal increased intrinsic connectivity group observed bilateral primary somatosensory cortex findings support use resting state fmri potential biomarker even confirm relationship brain changes pathophysiology longitudinal neuroimaging studies required
fact molecule mediate signals cell proliferation apoptosis prompted perform systematic investigation antigen expression tissues proliferation differentiation stages first targeted human intestinal cells positive results epidermis dynamic epithelium constantly renewed throughout life basal layer attached membrane contains dividing cells skin cells move layer undergo differentiation formation differentiated cell called intriguing find cells basal layer express antigen investigated immunohistochemical expression antigen paraffin embedded tissue samples representing epidermis epidermal spontaneous abortion weeks gestation respectively using monoclonal antibody northern blotting analysis additionally performed results showed epithelial cells epidermis developing skin express antigen expression epithelial cells higher cases hormonal administration normal gestation similar positive reaction involved epidermal associated development skin northern tissue sections using cdna probe detected mrnas molecular mass variety similarly positive control cell line
closed loop frequency tracking electronics circuit proposed measurement pressure temperature using newly developed crystals ambient force heat applied crystal produces shift resonant frequency proposed closed loop electronics tracks shift resonant frequency measures pressure temperature relating difference frequency shift steady state oscillation condition resonator circuit analytically derived experimentally verified experimental setup consists operational amplifier based resonator circuit connected crystal placed double side forces loading device temperature controller bath force applied crystal produces frequency shift fundamental mechanical vibration mode similarly change temperature produces frequency shift second mechanical mode frequency shifts measured using two separate closed loop resonator electronics two different whenever force crystal changed external unknown pressure additional intrinsic material property change added changes fundamental oscillating resonant frequency closed loop resonant circuit tracks change resonance frequency new resonance frequency depends external pressure strength similar procedure followed temperature induce frequency tracking measurement also proposed frequency tracking electronics concept simple found high sensitivity linearity
work describes innovative educational project related three subjects degree materials engineering involves coordination among subjects production new educational material implies active participation students favour autonomous learning development generic specific skills associated subjects methodology consists learning based real industrial problems divided two parts analyzed solved diverse points view subject physical problems solved subjects electronic thermal behavior materials optical magnetic behavior materials second part treated subject ceramic materials example real industrial application optical fiber associated problems materials specific optical properties another important aspect selection ceramic material choice design manufacturing process etc new procedures evaluation acquired knowledge developed skills established evaluate success activities opinion students taken account voluntary anonymous surveys
photonic phase implemented using two cascaded polarization modulators proposed experimentally demonstrated first employed generate optical carrier two first order polarized polarization directions optical carrier two first order first two principal axes second complementary phase modulation optical carrier first order produced voltage applied second selecting optical carrier one using optical filter signal phase tunable tuning applied voltage generated proposed phase advantages fast tuning frequency tunable range experiment performed full degrees phase shift frequency range ghz demonstrated spurious free dynamic range phase also studied
need clarify phase transition propagation phenomena shape memory alloy extremely small scale compressive loading present study strain stress curves temperature rise phase transition volume plastic volume hardness smart material static dynamic loading discussed hypothesis proposed propagation phase transition volume stressed spot according curve loading stages evidences discrete propagation phase transformed zone elsevier ltd rights reserved
accurate behavioral measurement essential developing science leadership yet accurate measurement remained elusive use follower reports leader behavior creates challenges given large body basic applied research suggests behavioral ratings reflect recall actual behaviors also inferences based semantic memory vary among individuals paper examine several explanations effects associated follower individual differences contextual factors even research methods type measure used bias ratings leader behavior also develop conceptual model illustrate processes finally offer potential solutions increase accuracy follower reports leader behavior elsevier inc rights reserved
genomics disruptive technology revealed cancers complex differ patient patient therefore conventional treatment approaches fit poorly genomic reality furthermore likely type complexity also observed illnesses precision medicine way better target disease related aberrations developing drugs tailoring therapy patients complicated problem major challenge one solution match patients existing compounds based silico modeling however optimization complex therapy eventually require designing compounds patients using computer modeling just time production perhaps achievable future three dimensional printing indeed printing potentially virtue ability rapidly generate almost numbers objects previously required manufacturing facilities companies already develop affordable home use attractive yet explored application place chemical design production digital control accomplished utilizing initiate chemical reactions print reagents final compounds directly interest food drug administration fda recently approved printed drug indicated seizures now increasingly clear biologic materials tissues eventually organs also printed near future plausible high throughput computing deployed design customized drugs medicine
objective determine whether lymphocyte depletion act promote immunological tolerance induction way intravenous antigen administration used either improve efficiency multiple sclerosis inhibition inhibit secondary occur following use relapsing experimental autoimmune encephalomyelitis induced mice immune cell depletion therapeutically applied using mouse conjunction monoclonal antibodies immunological subsequently induced using intravenous central nervous system antigens responses assessed clinically dose response monoclonal antibody depletion indicated functional cell depletion achieved perceived failed trials perhaps low even stop disease animals however marked similar physical depletion cells antibodies inhibited relapsing disease surprisingly contrast depletion depletion blocked robust immunological mechanism involving cells although efficacy related level cell depletion observations depletion cells less marked lymphoid organs blood provides rationale rapid cell hyper occurs following administration cells relative absence cell regulatory mechanisms promote immune tolerance account secondary cell occur following treatment
objective study compare moderate vigorous physical activity minutes per week min current recommendation min based different cut points postmenopausal women sample composed postmenopausal women aged years old measured using accelerometers accelerometers collect participants included using least days min obtained using cut points box plot indicated large mean differences almost cut points except min proportion women achieved min similar cut points resulted greater proportion cut points concluded cut points analyzed generated different results min low agreement using current guidelines pattern classification except comparisons cut points
impairments angiotensin system diabetes mellitus leading dysfunction known since decade hyperglycemia induces several pathological alterations system accounting overexpression downstream signaling molecules amongst angiotensin hold prime pathological although known elevated plasma levels play crucial role pathophysiology type diabetic mellitus inducing insulin resistance quite much known equally possibility risk development diabetic complications also amongst various diabetic complications effects upregulation widely acknowledged studies concerning pathophysiology diabetic nephropathy however role diabetic received much attention indeed plays detrimental role progression diabetic principal events involved pathogenesis namely oxidative stress angiogenesis inflammation utility angiotensin receptor blockers shown positive results research studies hence potentially provide novel adjuvant therapy treating complication preventing associated vision loss diabetic patients elsevier inc rights reserved
recent years government proposed number laws attempt control sexual conduct population much debated anti signed february constitutional grounds august known examples include legal measures related hiv aids article analyzes contexts laws recent public debates sexuality emerged consequences argue seen relation ongoing power local national level men women youth state citizens based discourse analysis drawing ethnographic show state non state actors exploit popular concerns recent processes social change sexuality extend control reinforce normative order based values
priority wise resources key successful environmental management especially limited study hand successfully developed algorithmic criterion compare hazardous effects municipal solid waste sites quantitatively multi criteria analysis made use scaling function normalize data values analytical hierarchy process ahp assigning weights input parameters showing relevant importance weighted linear combination normalized scores input parameters divided three classes namely residents concerns groundwater vulnerability surface facilities remote sensing data gis analysis used prepare input data elaborate idea four chosen case study namely old new comparison made first class levels class scores aggregated environmental normalized index environmental impact ranking hierarchy found selected sites new old comparative scores environment respectively flexibility proposed model adjust number classes parameters one class helpful developing world availability data biggest research based environmental sustainability planning model run even without satellite data gis software little using imagery measurement tools provided google earth
background capital femoral frequent disorder adolescent hip lead necrosis femoral head early osteoarthritis due post slip deformity proximal femur warrant best possible outcome affected contralateral hip early diagnosis proper treatment needed methods review literature undertaken identify todays role available imaging modalities management summary review outlines different imaging modalities radiography ultrasound mri bone treatment patients standard radiography first choice imaging modality patients suspected ultrasound advanced imaging modalities aid surgical planning diagnosis complications treatment follow
text input important part data annotation process text used capture ideas comments text entry virtual environments standard usually work various approaches proposed solutions mostly proven effective still remain certain shortcomings making investigations motivated recent research propose speech based multimodal text entry system simplicity maintaining good performance initial user study compared approach smartphone based text entry within like virtual environment results indicate reaches average input rate words per minute positively received users terms user experience
increase types numbers household appliances electrical appliances energy consumption attracted peoples concern reduce energy waste household appliances method energy saving control household appliances presented paper presented method indoor electrical circuits two parts one circuit powered turned algorithm detected current information infrared sensor information put forward assure circuit cut household appliances circuit powered states home also software hardware design schemes given detail energy saving control devices appliances developed last experiments made experimental results observe developed system reliable great importance energy conservation
among teen mobile phone users rise study examines adolescent mobile phone users perceptions harmful effect two people romantic relationship mass internet results survey adolescents showed respondents believed greater harm others furthermore respondents perceived messages internet harmful mass turn harmful two people additionally found gendered effect third person perception males females believed females perception girls boys victims predicts willingness support restrictions hand respondents less willing support restrictions
permeability measurement method based perturbed pressure decay source sink communicating porous medium formulated gas corrections due adsorption considered method allows infer permeability given rock fluid state accuracy method evaluated comparison theoretical decay characteristics modal amplitudes quantitative evaluation experimental inference therefore possible based pressure decay theory apparatus built laboratory measuring permeability presented secondary output data analysis also provides porosity lowest permeability present apparatus capable characterizing additional improvements capability anticipated steady state pragmatic excellent agreement two measurements showed validating method measurements synthetic samples also show method accurate porosity data standard confirm porosity obtained decay method american institute chemical engineers
dietary put participate array roles human metabolism nevertheless physiological conditions undesirable meat meat products among important sources human nutrition mainly usual contents put fresh respectively current information changes meat storage corresponds put formation bacterial activity mainly however data changes meat storage inconsistent processing meat probably change levels put formed different meat products relation microbial population raw materials used level manufacturing process contents seem remain stable processing non meat products decrease dry cured put contents increase commonly dry spontaneously however contents several hundreds extraordinary cultures usually able decrease put formation considerably contents dry comparable levels typical fresh meat data changes storage inconsistent decrease storage period usually reported elsevier ltd rights reserved
background small non coding rnas important regulators gene expression eukaryotes previously micrornas mirnas identified furthermore intermediate size systematically identified results performed systematic identification analysis small rnas associated protein using seq identified various types small associated showed multimodal length distribution three peaks similar similar similar included element rrna derived small rnas mirnas derived fragments found extremely high abundance accounted associated small rnas northern blotting confirmed many expressed regulated infected cells implying play prominent role binding infection additional evidence suggested potential cleavage sites anti codon psi loops derived small rnas also accounted significant proportion associated small rnas suggesting involved maintenance genome stability suppressing activities guided small rnas finally northern blotting also used confirm rrna derived small rnas demonstrating various novel small rnas exist conclusions using seq method combination northern blotting identified various types small rnas associated protein including rrna derived small rnas mirnas findings provide new clues future functional studies role small rnas insect development evolution
although mediated genome editing proven powerful genetic tool eukaryotes application bacteria limited inefficient targeting repair application yet reported describe development mediated genome editing tool allows facile genetic manipulation slow growing introduction insertions deletions homology directed repair remarkably efficient precise occurring frequency approximately relative transformation efficiency desired mutation found essentially transformants examined target activity observed also observed multiple single guide rnas expressed transcript reducing size plasmids simultaneously simplifying design mediated genome editing reduces time needed construct mutants half allows simultaneous construction double mutants high efficiency exponentially decreasing time needed complex strain constructions furthermore non homologous end joining machinery closely related allowed efficient mediated genome editing without need repair template dependent mutations included deletions ranging length appear occurred regions naturally occurring combination homology directed repair dependent dependent genome editing tools comprises powerful genetic system enables facile insertion deletion genes rational modification gene expression testing gene
newborns prone fungal infections largely due candida species immunological basis vulnerability yet fully understood however useful insights gained knowledge maturation immune pathways particularly placed context rare genetic mutations humans predispose fungal diseases article review current data immune functions human newborns highlighting pathways relevant response candida discussing data propose framework deficiencies pathways make newborns particularly vulnerable opportunistic pathogen
background established gold standard diagnostic investigation detection shoulder disorders aimed compare diagnostic accuracy magnetic resonance detection shoulder disorders methods patients underwent single surgeon preoperative february march shoulder instability identified reported experienced musculoskeletal radiologists tears anterior tears superior anterior posterior lesions posterior tears tears rcts osteoarthritis loose bodies lesions identified sensitivity specificity positive predictive value negative predictive value positive likelihood ratio negative likelihood ratio calculated results total patients identified sensitivity specificity anterior tears lesions posterior tears tear lesions rcts osteoarthritis loose bodies respectively positive predictive value negative predictive value anterior tears lesions posterior tears tear lesions rcts osteoarthritis loose bodies respectively conclusions high diagnostic accuracy tears lesions whether first line imaging modality controversial
background investigated potential role interleukin family members induction inflammatory responses human colonic methods expression inflammatory cytokines leukemia inhibitory factor matrix mmp mmp evaluated enzyme linked immunosorbent assay northern blotting activation mitogen activated protein kinase mapk assessed immunoblotting results significantly enhanced mmp mmp secretion effects relatively stronger induced effects modest compared induced augmented beta induced secretion mmp mmp similar augmentation also observed tumor necrosis factor tnf alpha induced cytokine mmp secretion rapidly induced phosphorylation extracellular signal regulated kinases erk jun terminal kinase early stimulation inhibitors erk mapk significantly reduced induced mmp mmp secretion conclusions among family members strongly stimulate human colonic inducing inflammatory responses
ionic mixtures measured specific conductivity increasingly concerned toxicities aquatic organisms however identifying protective values specific conductivity aquatic organisms challenging given laboratory test systems examine salt species effects occurring streams large data sets used deriving field based benchmarks rarely available study field based method small data sets used derive specific conductivity benchmark expected prevent local taxa neutral alkaline waters dominated mixture dissolved ions compensate smaller sample size species level analyses combined genus level analyses benchmark based concentration values specific conductivity genera estimated sampling sites river basin derived specific conductivity benchmark using point interpolation method yielded benchmark study tailored method developed derive aquatic life benchmark specific conductivity basin scale application provide useful information water pollution control management elsevier ltd rights reserved
nuclear magnetic resonance spectroscopy exploited study metabolic characteristics phenotype genetic disorders taking advantage unique characteristics technique first application metabolic profiling diagnosis therapeutic monitoring vitro demonstrates exceptional diversity metabolites detected nmr resulted new interest significant metabolites largely ignored previously techniques detect moreover previously unknown genetic disorders detected characterised nmr technique effectively exploited metabolic profiling mutation models yeast mice leading prominent role development large scale profiling link genomic information phenotype second application magnetic resonance spectroscopy exploits unique possibility studying human metabolism vivo permits intracellular rather extracellular metabolic profiling possible detect precise diagnostic metabolites vivo investigators able link clinical status cellular biochemistry sometimes questioning clinical value extracellular plasma metabolite measurements thus claims made brain concentrations match closely clinical status patients studies vivo also led new diagnoses disorders synthesis transport highlighting new category brain syndromes future applications nmr considered critically dependent continued improvement resolution sensitivity turn generated developments magnet design higher fields
owing rapid development earth observation technology volume spatial information growing rapidly therefore improving query retrieval speed large rich data sources remote sensing data management systems quite urgent global model geographic coordinate grid one dimension integer coding tree propose solution used data management organizations however spatial object cover several grids ample data redundancy occur data stored relational databases solve redundancy problem first combined model spatial array database containing inverted index proposed improved approach integrating managing massive remote sensing data adding spatial code column array format database spatial information remote sensing meta data stored subdivided implemented method enterprise server database system compared results oracle platform simulating worldwide image data experimental results showed approach performed better oracle terms data integration time space efficiency approach also offers efficient storage management system existing storage centers management systems society photo optical instrumentation engineers spie
number recent studies begun explore new exciting area interaction gut microbiome renal physiology particular multiple studies focused role produced short chain fatty acids generally thought promote health review focus known date regarding influence microbiome renal function emphasis cell biology physiology clinical implications short chain fatty acids short chain fatty acid receptors clear host interactions exciting ever expanding field implications view diseases hypertension acute kidney injury chronic kidney disease however important recognize although potential promise area extremely edge new field
assembly tedious time consuming work operators check assembly find right hole hence paper aims develop three dimensional projection system projects assembly instruction onto work piece surface directly guide operators assemble however order project instruction accurately corresponding part computer aided design model physical scanned area needs attained rapid accurate registration order achieve goal first high accuracy rapid measurement system developed second fast registration method based local multiscale geometric feature vector proposed accelerate registration speed improve registration reliability experimental results demonstrate measurement accuracy developed system verify feasibility proposed registration method hence proposed method lead improved assembly efficiency decreased error probability making great contributions large scale structure assembly
little known patterns mechanisms exacerbate violence children article propose using ecological framework examine impact interpersonal violence children consider literature supports framework suggest future directions research fill identified gaps framework relationship violence children depends risk factors multiple levels including breakdown child protection systems displacement threats changing gender roles changing household composition living conditions early marriage exposure conflict emergency events alcohol abuse empirical evidence supporting proposed emergency violence framework limited cross sectional study designs propensity predominantly examine individual level determinants violence especially exposure conflict emergency events thus pressing need relationship conflict emergency events violence children within wider ecological household dynamics occur ultimately require longitudinal observations children families communities emergency recovery improvements ongoing global surveillance systems complete data enable community design effective appropriate targeted interventions
background ecg monitored outpatient cardiac rehabilitation routinely performed following variety cardiovascular procedures conditions objective aim study determine diagnostic quality ecg monitoring patients coronary artery disease cad useful identifying asymptomatic myocardial ischemia resulting change care medical management methods retrospective analysis ecg monitoring done patients diagnosed cad january june results nearly quarter patients displayed least asymptomatic segment depression point least session patients medical management change compared show ecg changes suggesting ischemia patients asymptomatic ischemia medical management change resulted directly staff detection fewer patients diagnosed myocardial infarction coronary artery bypass graft surgery demonstrated ecg signs ischemia whereas patients diagnosed stable percutaneous coronary interventions demonstrated ecg signs ischemia conclusion study demonstrates patients cad showing asymptomatic ecg signs suggesting ischemia undergo medical management change result finding diagnostic quality ecg monitoring appears warranted population
paper proposes new lightweight cipher balanced structure cipher supports bit bit key length total rounds needs bit key length also results minimal memory size compared existing lightweight paper discusses security analysis cipher design adequate linear differential attack zero correlation attack algebraic attack cipher design best suitable applications like iot smart wireless sensor networks cipher uses two functions substitution box results high diffusion mechanism
article addresses problem creating interactive mixed reality applications virtual objects interact images real world scenarios relevant create games architectural space planning applications interact visual elements images walls empty spaces scenarios intended captured users regular cameras using previously taken photographs introducing virtual objects photographs presents several challenges pose estimation creation visually correct interaction virtual objects boundaries scene two main research questions addressed article include study feasibility creating interactive augmented reality applications virtual objects interact real world scenario using image detected high level features also verifying users capable motivated enough perform initialization steps proposed system detects scene automatically image additional features obtained using basic annotations user operation significantly simple accommodate needs non expert users system analyzes one photos captured user detects high level features points floor scene orientation using features possible create mixed augmented reality applications user introduces virtual objects blend picture real time respond physical environment validate solution several system tests described compared using available external image datasets
article employs understanding creativity defined terms big creativity associated high culture small creativity concerned constructive life strategies comparative study films youth focusing representations ageing ways film suggests life experience vice versa film based varying scenarios late life big creativity article explores contrasts small creativity suggested article argues varying degrees different ideological implications film points importance late life creativity
physico chemical changes tendency accumulate various organs organisms especially fish turn enter human metabolism consumption causing serious hazards hence present study carried determine physico chemical characteristics water southeast coast india period year september august environmental parameters temperature salinity nitrate phosphate observed department college india period study air temperature varied degrees surface water temperature also varied degrees monthly mean values hydrogen ion concentration water varied salinity water varied parts per thousand dissolved oxygen varied total phosphorus varied nitrate varied content varied totally collected belonging orders families found dominant species study area
objective study explored attitudes experience menopause among women living australia including attitudes responses hormone therapy complementary therapies related psycho sexual relationship issues methods using qualitative methodology study based seven unstructured group discussions natural social groups recruited meeting group felt home total participants ranged age years women included first generation immigrants women born australia parents researcher conducted results participants typically claimed lacked information menopause native language knowledge highly variable women felt comfortable approaching doctors others reported symptoms deeply religious participants claimed helped phase life likely doctor theme men tended regard differently menopause sometimes treating non sexual women regarded shift male attitudes factor domestic violence symptoms hot mood associated negative attitudes toward menopause conclusions culturally determined attitudes appear affect perception experience menopause influencing factors include migration womens roles marital status religion use herbal traditional social situation access information knowledge experience menopausal symptoms
randomized controlled trial aims test efficacy group intervention free women overweight obesity based mindfulness act compassion approaches intervention aimed reduce weight self stigma unhealthy eating patterns increase quality life qol seventy three women aged years old bmi without binge eating seeking weight loss treatment randomly assigned intervention control groups free comprises group sessions plus sessions control group maintained treatment usual tau data collected baseline end free intervention overall participants enrolled free found intervention important helpful dealing weight related unwanted internal experiences moreover compared tau free group revealed significant increased health related qol physical exercise reduction weight self stigma unhealthy eating behaviors bmi self weight related experiential avoidance psychopathological symptoms post treatment results self compassion showed trend towards significance whereas significant groups differences found mindfulness taken together evidence found free efficacy reducing weight related negative experiences promoting healthy behaviors psychological functioning qol elsevier ltd rights reserved
facial expression reconstruction important issue field computer graphics relatively easy create animation based meshes constructed video recordings kind high quality data often transferred another model lack based way however high quality mesh sampled sufficient density possible use obtained feature points encode shape surrounding vertices way easily transferred another mesh corresponding feature points paper present method used obtaining information purpose changes facial surface basis selected feature points
factors dramatically influencing thermal comfort usually involve air temperature temperature air humidity air velocity insulation metabolic rate however special conditions altitude environment air pressure taken account exposure altitude tends produce deterioration human heat diffusion performance rate convective heat transfer decreases rate convective heat transfer increases altitude energy balance human body environment different normal conditions experiments thermal perception test persons person times observed subjective questionnaire simulated chamber air parameters controllable temperature set degrees conditions set simulated conditions corresponding altitude respectively experiments solved metabolic rate raised pressure drop measured differed actual thermal sensation conditions moreover falling pressure leads decline alveolar oxygen variety adaptive physiological processes oxygen delivery human metabolism responses thermal perception change however present thermal sensation models built normal environment many conclusions combined experiments article builds thermal sensation estimating model conditions principal component analysis purpose study make clear whether exposure affect peoples thermal sensation helpful establish indoor thermal comfort criterion environment
purpose aim study determine whether categories contraception differ impact seizures women epilepsy whether impact varies drug category methods retrospective survey data came contraceptive experiences reported women epilepsy compared risk ratios reports increase decrease seizure frequency hormonal versus contraception stratified drug categories results women epilepsy reported change seizures hormonal contraception risk ratio seizure increase hormonal versus contraception risk ratio seizure decrease hormonal versus contraception hormonal contraception risk ratio seizure increase greater decrease comparison combined pills hormonal patch progestin pills greater risk ratios seizure increase hormonal method greater risk ratio seizure decrease combined pills seizure increase greater hormonal contraception drug category hormonal contraception relative non enzyme inducing drug category lowest rate categories significantly greater risks seizure increase especially enzyme inhibiting category risk ratio conclusion findings provide community based epidemiological survey evidence contraceptive methods differ impact seizures impact vary drug category published elsevier inc
enzyme synthase catalyzes two molecules key precursor biosynthesis full length cdna encoding synthase designated isolated kind important medicinal plants producing potent anti cancer drug full length cdna contained open reading frame orf encoding polypeptide amino acids bioinformatic analysis revealed deduced protein high similarity plant predicted crystal structure similar class biosynthetic enzymes southern blot analysis revealed one copy gene genome semi quantitative pcr analysis northern blotting analysis showed expressed constitutively tested tissues highest expression roots promoter region also isolated genomic walking analysis showed several cis acting elements present promoter region results treatment experiments different signaling components including methyl acid revealed expression level treated cells prominent diversity control consistent prediction results promoter region database
today failure modes characterization early detection key issue complex assets due negative impact corrective operations conservative strategies usually put practice focused preventive maintenance paper anomaly detection issue addressed new monitoring sensor data characterizing modeling operational behaviors learning framework performed basis machine learning approach combines constrained means clustering detection fuzzy modeling distances final score also calculated time considering membership degree resulting fuzzy sets local factor proposed solution deployed platform online monitoring assets order show validity approach experiments conducted real operational faults auxiliary marine diesel engine experimental results show fully comprehensive yet accurate approach improving detection capabilities knowledge management performance achieved quite high precision sensitivity specificity even given small percentage real faults present data elsevier rights reserved
assess reach acceptability effect video showing breast feeding skin skin care sucrose blood sampling intention recommend video advocate use interventions july video electronic survey produced year online survey responses analytics analyzed one year video views countries viewers completed survey respondents aware analgesic effects breast feeding skin skin care sucrose nearly respondents found video helpful resource answered recommend video others viewing video respondents answered advocate interventions video showing effective pain treatment blood sampling large reach small response rate survey therefore analysis acceptability effect intention recommend video advocate interventions depicted limited research warranted explore best evaluate videos delivered social media determine effect video promote knowledge translation clinical practice
problem national occupational injury prevention goals often prioritize reduction serious injuries study analyzed whether prioritization respect lost time injuries short long term work absence implications injury severity based versus injury absence based prevention approaches method data consisted national work site specific injury absence data construction workers denmark including workers construction sites period results impact industry government absence length significantly dependent type injury sprains strains prevalent accounted approximately one third injuries absence fractures accounted one sixth injuries greatest proportion long term absence results give credibility need targeting sprains strains injury absence prevention initiatives national safety council elsevier ltd rights reserved
investigate particular aspect trustworthiness critically important firm engaged financial specifically drawing prior research suggests facial appearance one critical way trustworthiness argue leaders convey integrity component trustworthiness likely selected financial predict positive reactions external observers investment media perceived greater integrity study firms financial find support predictions findings implications research leadership selection facial appearance firm
goal study determine effect acute potential subcutaneous adipose derived stem cells post menopausal women post menopausal women mean age years treated weeks randomized cross design placebo patches biopsies abdominal femoral fem subcutaneous adipose tissue obtained treatment mature adipocytes analysed cell size capacity proliferation growth rate differentiation triglyceride accumulation susceptibility tumour necrosis factor alpha induced apoptosis gene expression receptors hormone sensitive lipase also assessed fem weeks significantly increased differentiation whole mrna expression compared placebo changes associated mrna expression receptors expression significantly increased fem treatment adipose derived stem cells proliferation apoptosis change either compared placebo short term appeared increase potential fem post menopausal women possible implications metabolic disease future studies needed determine longer term impact regional accumulation context positive energy imbalance
animal experimental studies indicate acute chronic low dose radiation low dose rate radiation exposures harmful induces genetic epigenetic changes associated range physiological disturbances includes altered immune system abnormal brain development resultant cognitive impairment abnormal embryonic development diseases weight gain premature menopause female animals tumorigenesis shortened lifespan paternal prenatal exposure associated reduced fertility number live fetuses genomic aberrations hand experimental studies exposure also reported bring beneficial effects reduction tumorigenesis prolonged lifespan enhanced fertility differences reported effects exposure dependent animal genetic background susceptibility age prenatal postnatal days sex nature radiation exposure acute chronic radiation exposure type radiation combination radiation toxic agents smoking pesticides chemical toxins animal experimental designs review paper aimed update radiation researchers radiologists current progress achieved understanding induced effects reported various animal models roles played variety molecules implicated induced health effects elaborated review help future investigations induced health effects providing clues designing improved animal research models order clarify current controversial contradictory findings existing studies
background atopic dermatitis eczema chronic inflammatory disorder associated sleep disturbances quality life impairment sleep disturbances shown cause headaches childhood however association eczema headaches established objectives sought determine whether childhood eczema associated increased headaches whether association related fatigue sleep disturbance methods analyzed data children adolescents population based cross sectional studies national survey childrens health national health interview survey results multivariate models controlling age sex race ethnicity household income highest level education family insurance coverage number persons household united states ever history asthma fever food allergy eczema found associated headaches studies pooled analysis studies children eczema compared without eczema significantly higher prevalence odds headaches mild severe eczema associated significantly higher odds headaches particular eczema associated atopy fatigue excessive daytime sleepiness insomnia sufficient sleep even higher odds headache eczema alone conclusions eczema associated increased headaches childhood particularly patients severe disease accompanied atopy fatigue sleep disturbances
paper investigate power efficient resource allocation algorithm design secure wireless communication systems employing full base station serving multiple half users simultaneously propose multi objective optimization framework study two conflicting yet desirable design objectives total transmit power minimization total transmit power minimization end method adopted formulate resource allocation algorithm design multi objective optimization problem considered takes account quality service requirements legitimate users guaranteeing secure transmission presence potential thereby secure transmission enabled possible channel state information channels inter user interference channels incorporated robust resource allocation algorithm design although considered non convex solve optimally programming relaxation simulation results trade total transmit power total transmit power also confirm robustness proposed algorithm potential
breast contaminated substances exposure early stages life lead adverse health effects among infants date acid frequently measured breast worldwide information shorter carbon chain breast milk scarce study breast sampled korean women measured seventeen including ten four three detected breast milk samples median concentrations respectively acid acid acid detected higher frequencies ranging concentrations short carbon chain breast milk highest ever reported date comparable concentrations shorter chain breast milk tended higher among women longer lactation period showed opposite trend suggesting possibility breastfeeding important route excretion among women fish consumption use consumer products skin care products cosmetics non coated cooking identified significant predictors concentrations breast milk health risks associated exposure breastfeeding estimated negligible however risks short carbon chain assessed lack relevant toxicological information efforts source identification exposure management measures shorter chain necessary elsevier inc rights reserved
new environmental laws restricted use trees overhead power lines structures poles cross arms leading companies seek alternative materials wood coated polymeric resin proposed environmental friendly solution improved electrical properties protection external agents moisture ultra radiation fungi however single thin layer resin normally applied structures reveal inefficient due easily damage handling paper present composite coating based geotextile fibers resin suitable structures results obtained two different tree species managed areas coated composite reveal additional layer provided stronger adhesion wood layer also improvement electrical properties better protection moisture
relevant tropical crop physico chemical changes take place quickly consequence activation biochemical pathways synthesis several proteins thus order information changes gene expression transcripts pulp fruit differential display pcr pcr seventy transcript derived fragments isolated amplified pcr differential expression genes confirmed reverse northern blotting twenty nine positively cloned sequenced identified homology search ten genes downregulated glucose alpha inhibitor like protein protein identified among regulated genes integral membrane family protein hydrolase family like protein considering relatedness quality fragments genes potentially implicated carbohydrate metabolism pulp considered interest studies according results differential display feasible approach investigate differences gene expression fruit provide interesting information fruits whose genomic data scarce case elsevier rights reserved
investigated risk cannabis use disorder among function parental psychopathology explored parent offspring gender concordance mechanism parental transmission offspring waves data collection longitudinal epidemiological study psychopathology among representative sample selected randomly western usa initially assessed mid adolescence reference sample included biological mothers fathers episodes among assessed semistructured diagnostic interviews mid adolescence young adulthood life time psychiatric disorders among parents assessed approximately age increased risk onset among parental histories hazard ratio confidence interval hard drug use disorders antisocial personality disorder significant parent offspring gender concordance effect indicated females maternal history higher risk onset compared females without maternal maternal associated onset among males evidence parent offspring gender concordance effects paternal specific transmission histories antisocial personality illicit substance use disorders associated increased risk cannabis use disorder onset offspring especially among females maternal cannabis use disorder histories
paper aimed review applications potentials early diagnosis bipolar disorders diagnostic efficacy differential diagnosis cognitive abnormalities clinical symptoms databases pubmed embase web sciences google scholar searched using search terms quantitative bipolar disorders early diagnosis differential diagnosis selected evaluations evidence indicates diagnostic efficacy early diagnosis bipolar disorders controlled clinical studies indicated extracted measures diagnostic value early differential diagnosis conventional assessments
prevalence obesity increasing massively several decades countries obese women sexually active use fewer contraceptive methods high risk unintended pregnancy addition obesity important risk factor venous thromboembolism events arterial thrombosis myocardial infarction ischemic stroke data considered choosing contraceptive method obese women except acetate injection progestin contraceptives progestin pills implant intra uterine devices preferred contraceptive methods obese women combined estrogen progestin contraceptives pill patch vaginal ring proposed strict conditions associated vascular risk factor obesity increase risk failure contraceptive methods bariatric surgery complex situation requires program possible pregnancy contraception needed several months bariatric surgical techniques pass induce gastrointestinal situation oral contraceptives recommended higher risk failure elsevier masson sas rights reserved
objective estimate prevalence unintended pregnancies relaxed assumptions regarding birth control use compared traditional constructed measure design cross sectional survey setting applicable patient nationally representative sample women aged years intervention none main outcome measure prevalence intended unintended pregnancies estimated traditional constructed measure national survey family growth constructed measure assumptions regarding birth control use reasons pregnancy timing result prevalence unintended pregnancies higher using traditional constructed measure compared approach relaxed assumptions confidence interval new construct using approach women stopped birth control become pregnant women using contraceptives time pregnancy reported mind getting pregnant classified intended pregnancies compared using new construct conclusion current measures pregnancy intention rates unintended pregnancy pregnancies united states unintended using current approach corresponding estimated savings million public health care expenditures current constructs make assumptions reflect contemporary reproductive practices improved measures needed american society reproductive medicine
despite significant progress made study flame building materials quest find ideal flame material still continues review paper explores various options substitute flame free alternatives green building materials conventional flame chemically react building materials owing remain part substrate easily due various factors leading low efficiency flame action durability flame ensured applying additive chemically react least one ingredients green building material flame remain inherent part substrate paper also describes reaction mechanisms various treatment methodologies ensuring efficacious actions non flame green building materials wood
paper consider distributed setting computational mobile entities called robots perform tasks without global coordination depending environment robots capabilities tasks accomplished particular focus known scenario robots reside nodes graph operate look compute move cycles one cycle robot current configuration terms robots positions look whether move toward edge graph compute positive case performs instantaneous move along computed edge move compare two basic models first model robots fully synchronous second one robots asynchronous enhanced robot equipped constant number visible robots question whether one model powerful terms tasks considered distributed computing systems robots moving euclidean plane rather graph provide two different tasks show graphs one task solved fully synchronous model asynchronous enhanced model task holds hence fully synchronous model asynchronous enhanced model graphs opens challenging directions order understand make models different
revisit equilibrium one dimensional phi model dynamical systems point view find infinite number periodic computationally stable time found exhibit positive lyapunov periodic every particle periodic chain trace either mirror image trajectory two dimensional phase space computationally stable sets pairs single particle either symmetric last computational bit periodic chain odd even particles coordinates either identical differ sign positive lyapunov result perturbation breaking perfect two dimensional introduced motion expands four dimensional phase space extended space positive exponent results formulate standard initial condition investigation chaotic number dependence model speculate uniqueness models chaotic sea connection collections deterministic time reversible states second law thermodynamics elsevier rights reserved
disease small intestine rare especially located generally asymptomatic patients complications acute gastrointestinal bleeding obstruction cases recommended treatment surgery report year old patient crohns disease long standing inflammatory phenotype developed acute presenting severe septic shock secondary multiple organ failure resolved medical treatment prolonged antibiotic therapy
post exposure prophylaxis biomedical approach hiv prevention administered potential exposure virus although originally approved occupational exposure hiv among healthcare workers remained controversial method preventing hiv infection following sexual exposure examine emerging social representations undertook qualitative thematic analysis articles published focused print media still reflect broader societal debates set agenda wider discussions media contribute shaping public perceptions policy priorities findings show two major social representations use hiv prevention amongst gay bisexual men positive social representation relatively straightforward solution framed morning pill negative social representation risks yielding uncertain outcomes also found third social representation use amongst public health care workers represented needed positive representation generally consisted statements negative representation substantiated expert rendering latter representation generally found lack technical information information gap inhibit informed discussion lead social representations users
new grounded capacitor single resistance controlled sinusoidal oscillator explicit current output using two current five passive elements presented proposed circuit offers independent control condition oscillation frequency oscillation low active passive sensitivities iii use grounded capacitors suitable implementation reasonably good frequency stability proposed configuration confirmed pspice simulations
recent success cancer immunotherapy anti anti confirmed hypothesis immune system control many cancers across various cases producing durable responses way seen many small molecule drugs however less patients respond drugs several resistance mechanisms identified cell overexpression caspase beta catenin gene amplification mhc mutations improve response rates overcome resistance novel second third generation immuno oncology drugs currently evaluated ongoing phase trials either alone combination including novel inhibitory compounds lag newly developed antibodies important note agents strikingly differ proposed mechanism action compared monoclonal antibodies accomplish immune activation blocking negative checkpoint molecules others indeed prospect combining agents represents real immunologic opportunity step gas cutting although strategy novel cancer therapy universally endorsed far concerns include prospect triggering cytokine release syndromes autoimmune reactions hyper immune stimulation leading activation induced cell death tolerance however toxicity major issue clinical trials reported far although initial phase clinical trials novel drugs shown highly promising results absence disabling toxicity single agent studies combination chemotherapy immune system targeting drugs however numerous questions remain dose schedule route administration formulation identifying appropriate patient populations view wealth potential mechanisms action ability fine tune monoclonal antibody structure function suit particular requirements second third wave immuno oncology drugs likely provide rapid advances new combinations novel immunotherapy especially antibodies review mechanisms action clinical data new antibodies discuss major issues facing rapidly evolving field elsevier ltd rights reserved
complementary alternative medicine cam widely used menopause although women disclose use healthcare providers narrative review aims expand providers understanding cross cultural approaches treating managing menopause providing overarching framework perspective cam treatments increased provider understanding awareness improve provider patient communication also effectiveness treatments distinction illness patients suffer disease physicians treat highlights gap patients seek doctors provide help clarify many women seek cam menopause example cam often sought women unsuccessful review relevance menopause three cam categories natural products mind body practices including complementary health approaches including traditional chinese medicine japanese assessing effectiveness cam challenging individualized nature illness patterns associated treatments complicate design randomized controlled trials many women seek cam due biomedical treatments cultural economic biomedical practitioners make effort learn cam ask patients cam use interest dramatically improve patient provider relationship harnessing meaning response clinical encounter working women integrate cam related health seeking behaviors treatments providers also boost efficacy biomedical treatments elsevier rights reserved
suspensions source fascinating new fluid mechanics recently predicted active pipe flow dispersion whose orientation biased gravity flow shear analytical theory predicts active markedly distinct manner passive dispersion display non zero drift effective diffusivity non monotonic number predictions agree numerical simulations hitherto tested experimentally facilitate comparison obtain new solutions axial dispersion theory accounting negative local nonlinear response shear provided two alternative microscopic stochastic descriptions obtain new predictions suspensions model swimming whose motility mass using tracking video microscopy present new experimental method measure dispersion using stained provide preliminary comparison predictions non zero drift mean flow microscopic stochastic description finally propose experiments full experimental characterisation dispersion measures discuss implications results dispersion industrial
background anti myelin glycoprotein antibodies detected various demyelinating diseases pediatric acute disseminated encephalomyelitis recurrent optic antibody spectrum disorder present patient developed anti antibody positive following infectious due epstein barr virus ebv infection case presentation year old healthy man developed bilateral lower extremities urinary retention days onset due primary ebv infection mri revealed lesions cervical spinal cord internal capsule examination cerebrospinal fluid revealed cell based revealed positivity anti antibody negativity anti antibody symptoms quickly improved steroid pulse therapy followed oral anti antibody month follow negative conclusions case suggests primary ebv infection trigger anti antibody positive adult patients positive anti antibody titers correlate neurological symptoms
asthma allergy share similar close course especially childhood considerable research effort put associations however now becoming obvious difficult task fact research breakthrough picture steadily moving toward era personalized medicine begin thought single disease asthma fact accumulation distinct entities context syndrome characterized several yet poorly defined phenotypes question link asthma allergy probably becomes non relevant review revisit question emphasis multifaceted nature asthma
propagation analog single event transients multiple outputs bipolar junction transistor integrated circuits ics reported first time results demonstrate appear several outputs amplifier comparator result single ion single laser pulse single physical location chip large scale integrated analog circuit independent cross talk charge sharing effects laser experiments together spice simulations analysis propagation domain used explain multiple output transients generated propagate device study demonstrates charge collection associated shape commonly used characterize propagation sets devices systems unable explain quantitatively propagate integrated analog circuit analysis methodology adopted involves combining fourier transform propagating signal current source transfer function domain approach reveals mechanisms involved transient signal propagation point generation one outputs without signal following continuous path
novel animal model involving chimeric mice humanized livers established via human hepatocyte transplantation developed mice liver functional human hepatocytes serve useful tool investigating human hepatic cell biology drug metabolism preclinical applications one key factors required successful transplantation human hepatocytes mice elimination endogenous hepatocytes prevent competition human cells provide suitable space microenvironment promoting human donor cell expansion differentiation date two major liver injury mouse models utilizing hydrolase activator upa mice established however mice used mainly mature hepatocytes application upa model limited decreased breeding overcome limitations receptor mediated cell knockout scid mice used vivo differentiation immature human hepatocytes humanized liver generation human hepatic stem cells successfully livers scid mice developed lethal hepatic failure following toxin treatment model humanized liver scid mice functional applications studies involving drug metabolism drug drug interactions promote vivo vitro studies
broadly neutralizing antibodies associated spontaneous clearance hepatitis infection viral persistence immune escape study neutralizing antibody epitopes needed unravel pathways resistance virus identify conserved regions vaccine design reported broadly neutralizing antibody epitopes hcv envelope glycoprotein identified critical contact residues epitopes mapped onto linear sequence publicly available sequences downloaded contact residues within epitopes assessed level conservation frequency occurrence experimentally proven resistance mutations epitopes also compared two sequence datasets obtained collected defined time points acute days infections identify significant differences residue usage contact residues linear regions protein sequence analysis full length sequences databases showed experimentally proven resistance mutations present frequency comparison subtype viral sequences obtained samples collected acute chronic infection revealed significant differences positions changes residue position significant difference variability entropy majority experimentally described escape variants occur frequently nature observed differences acute chronically isolated sequences suggest constraints residue usage early infection elsevier rights reserved
contribution describes methodology computing compact time domain models electromagnetic devices containing lorentz materials finite element systems frequency domain procedure starts projection based model order reduction system dimension resulting reduced order model transformed time domain leads state space representation proposed method mathematically proved preserve important system properties including causality allows transient electromagnetic fields
hypothalamic neuropeptide oxytocin molecule among due pronounced prosocial effects potential use deficits characterize prevalent neurodevelopmental psychiatric disorders autism spectrum disorders schizophrenia effects studied young adult subjects either animals humans complete lifespan trajectories system development activity far less investigated mini review primarily focus three temporal distinct periods postnatal period puberty adolescence elderly selected neonatal period discuss role switch gaba action excitation inhibition first days birth rodents potential implications neurodevelopmental disorders puberty adolescence period consider particular relevance impact drug consumption stress aggression finally potentially contribute maintain social capacities aged people ameliorate socially emotional deficits symptoms neurodegenerative diseases wiley periodicals inc develop
objective joint united nations program hiv aids supported spectrum software package usa used countries worldwide monitor hiv epidemic spectrum hiv incidence trends among adults aged years derived either fitting surveillance survey data generating curves consistent program vital registration data historical trends number newly diagnosed infections people living hiv aids related deaths article describes development application fit program data tool joint united nations program hiv aids estimates tool hiv incidence trends described simple double logistic function function parameters estimated historical program data newly reported hiv cases people living hiv aids related deaths inputs adjusted proportions deaths maximum likelihood estimation minimum chi squared distance methods used identify best fitting curve asymptotic properties estimators fits used estimate tool used fit incidence countries maximum likelihood minimum chi squared distance methods gave similar results double logistic curve adequately described observed trends four countries simple logistic curve performed robust hiv related program vital registration data routinely available many middle income high income countries whereas hiv surveillance survey data scarce countries tool offers simpler improved approach estimating hiv incidence trends copyright wolters kluwer health inc rights reserved
objective study estimates hospital costs treating work related injury among cohort workers british columbia methods hospital discharge records extracted cohort actively employed workers injury cases identified work related records using icd external cause injury codes indicate place occurrence responsibility payment schedule identifies workers compensation responsible payment hospitals british columbia standard ward rate chart prepared annually ministry health collect payment agency like workers compensation agency costs calculated hospital perspective using chart costs expressed canadian workers compensation claim records study population extracted matched work related injury records costs also calculated work related hospital appear workers compensation system results injuries requiring year follow period median stay hospitals days median hospital costs costly cause injury categories fire flame natural environmental median costs respectively least costly category cutting median costs costly nature injury categories fracture lower limb median costs respectively least costly category dislocation sprains strains median costs total hospital costs work related injuries total hospital cost work related injuries compensation agency apparently compensate conclusion prevention work related injuries save significant amount health care resources substantial costs remain compensation agency thus transferred health care system annually elsevier ltd rights reserved
sizing farm pond various crop substitution ratios eastern india addressed present study cross polyethylene used root zone water balance model used simulate water harvesting potential maize rice fields various ratio maize rice areas daily variations soil moisture storage crop root zone supplemental irrigation requirement critical growth stages water balance using volume balance approach simulated years using soil crop meteorological data study area optimal size found farm area meet requirement rice sativa rainy season black gram winter among inflow components direct rainfall contribution major contributor surface runoff field year respectively among outflow components demand crops found storage respectively optimal size initial investment indian net profit benefit cost ratio internal rate return payback period years
attention deficit hyperactivity disorder adhd highly prevalent among adults addictive disorders little known addiction patterns associated adhd diagnosis study examined addiction severity patients occurring addictive disorders adhd controlling potential influence associated psychiatric comorbidity data collected french outpatient addiction treatment centers total patients seeking treatment substance gambling addiction included treatment entry participants interviewed addiction severity index adult adhd diagnosis interview dsm mini international neuropsychiatric interview mini structured clinical interview dsm axis borderline personality disorder scid history adhd associated earlier onset addiction poly dependence defined presence least two current substance dependence diagnoses addition tobacco dependence present borderline personality disorder persistence adhd adulthood associated higher prevalence poly dependence study highlights need early implementation preventive interventions substance use behavioral addiction children adolescents adhd need consider adhd treatment addictive disorders
research microstructure thickness interfacial transition zone cement lightweight aggregates studied established microstructure strongly depends nature aggregate specifically porosity water absorption study aims influence physical properties density porosity morphology lightweight aggregates expanded microstructure thickness determine effect factors turn mechanical properties compressive strength lightweight lightweight aggregates characterized ray diffraction xrd scanning electron microscopy sem ray fluorescence determine morphological chemical characteristics characterization sem eds conventional optical microscopy carried specimens concrete manufactured conventional aggregate order evaluate thickness furthermore determine porosity digital image processing performed lightweight aggregates contributed formation dense thinner compare conventional concrete lower porosity greater amount cement phases lightweight aggregates attributed physical morphological properties chemical composition contributed decrease wall effect surface formation achieving phases surface aggregates matrix elsevier ltd rights reserved
objectiveto evaluate changes cartilage associated bone treatment using ovariectomized osteoporosis rat model six month old female sprague dawley rats randomly divided sham treated groups groups received bilateral group treated subcutaneously saline whereas group received treatment subcutaneously months end months animals sacrificed entire harvested micro histological analyses immunohistochemistry performed assess expression type collagen protein imaging analysis analysis showed group significant bone loss compared sham shown significant decrease bone volume fraction trabecular thickness significant increase trabecular spacing group partial inhibition induced bone loss detected staining showed proliferative layer cartilage reduced hypertrophic layer increased significantly group compared sham groups showed reduced expression groups whereas expression reduced group increased group findings suggest systemic treatment influences structure ossification cartilage dual action postmenopausal osteoporosis rat model raises concerns potential side effects patients
purpose background aim study evaluate effects lithium actigraphy measured circadian parameters patients bipolar depression methods procedures week open label prospective randomized comparative study assessments included item hamilton depression rating scale score measures concerning previous days collected visit weeks baseline data analyzed analysis findings results medication time interaction medication time significantly associated entire group respectively specifically significantly delayed weeks respectively group statistics significantly increased time entire group significant increase statistics weeks group respectively weeks lithium group respectively addition scores item hamilton depression rating scale significantly associated statistics weeks entire group implications conclusions lithium affected several circadian parameters including peak activity time robustness circadian rhythm exerted different effects patients bipolar depression particular clinical depressive symptoms associated robustness circadian rhythm course week treatment
main objective study development correlation model dynamic bayesian belief networks followed inverse economic analysis based quadratic hierarchical bayesian inference prediction method using markov chain monte carlo simulations developed model implemented predict future degradation maintenance budget suspension bridge system bayesian inference applied find posterior probability density function source parameters damage indices given years maintenance data simulated risk prediction decreased conditions gives posterior distributions based prior distribution likelihood data updated annual maintenance tasks compared conventional linear prediction model proposed quadratic model provides highly improved convergence measured data finally developed inverse analysis method allows forecasts future performance financial management complex infrastructures providing sensitivity risky factors maintenance structural components overall system
deformations applied body tissues daily activities result morbid conditions various medical treatments affect cell viability biological function phenomena often studied vitro monolayer cultures facilitate studies cost effectively developed novel cell stretching apparatus apparatus used apply tensile strains cells cultured elastic either sustained dynamic cyclic application apparatus parts three printed excluding motors stretching automatically performed two direct current motors controlled programmable microcontroller platform demonstrate functionality novel device produced multiple copies research labs cost per unit including motors controller performed cell culture studies monitored fluorescence microscopy specifically applied sustained cyclic radial stretching large strains mouse fibroblasts demonstrated cell viability adhesion morphology maintained following stretching apparatus designed low cost rapidly manufactured university small company setting simple use control flexible versatile design allows users experimentally induce different stretching regimes varying amplitudes frequencies elsevier ltd rights reserved
prevalence hcv infection higher among general population introduction hcv direct acting holds potential improve clinical outcomes also however treatment hepatitis face several clinical issues peculiar prison environment recommendations management hcv infection specific setting era remain scant italian society medicine healthcare therefore issued recommendations provide clinicians guide comprehensive management hcv infection restriction setting taking account peculiar characteristics dedicated diagnostic treatment procedures established prison particular use appears crucial provide patients effective therapeutic option able overcome limitations ifn based regimens short period treatment treatment initiated soon possible eligible subjects aim cure patient limit transmission hcv infection inside system free community ends release importantly efforts made open discussion regulatory bodies define specific regulations aimed guarantee wide access effective therapies eligible patients optimize management adherence hcv treatment ensure therapeutic continuity discharge prison
although relatively new scientific trend managed become popular many countries including russia year history division molecular genetics studies ecosystem extracted nucleic acids dna rna contain full information microbial community habitat owing methods soil microbiology undertaken study known cultivated types microorganisms also forms biological properties suggested exclusively genetic information coded dna turns phantom types constitute overwhelming majority within soil microbial communities actively participate ensuring soil fertility hence opinion authors paper study topical basic research agricultural practice development technologies help understand biological phenomena determined close plant interactions increasing productivity agricultural crops protecting however introduction new methods always presented difficulties associated acquisition storage analysis huge array genetic information
main aim present recent developments applications symbolic computing probabilistic stochastic analysis done using example known maple system key theoretical methods discussed analytical classical monte carlo simulation approach iii stochastic perturbation technique semi analytical approaches demonstrated particular engage basic symbolic tools implemented system derive basic equations stochastic perturbation technique make efficient implementation semi analytical methods using automatic differentiation integration provided computer algebra program second important illustration probabilistic extension finite element finite difference methods coded maple showing solve boundary value problems random parameters environment symbolic computing response function method belongs third group interference classical deterministic software non linear fitting numerical techniques available various symbolic environments displayed recover context probabilistic structural response engineering systems show solve partial differential equations including gaussian randomness coefficients
study sought provide preliminary assessment whether mediated afferent hyperactivity central sensitization contribute manifestations overactive bladder syndrome oab women indexed elevated temporal summation evoked heat pain stimuli methodswe recruited adult women oab planning undergo interventional therapy oab either injection sacral neuromodulation healthy controls without oab symptoms undergo quantitative sensory testing cutaneous thermal pain temporal summation primary study outcome degree temporal summation reflected magnitude positive slope line fitted series stimuli degrees target temperatures linear regression analysis covariance utilized compare degree temporal summation study groups resultsthe standardized slope temporal summation trials women oab significantly higher controls confidence interval adjusted means standardized temporal summation slopes full oab control groups confidence interval confidence interval respectively preliminary study demonstrated women oab refractory primary secondary therapies exhibited greater thermal cutaneous temporal summation women without oab symptoms suggests central sensitization indexed temporal summation underlying factor contributing oab women neurourol urodynam wiley periodicals inc
dermatitis associated hematologic disorders including syndromes describe first case dermatitis associated polycythemia vera presenting large nodules mimicking also present case associated plaques face neck similar consider particularly interesting dermatologists aware nonspecific manifestation various hematologic disorders suggest performing additional tests complete blood count exclude possibility skin manifestations initial sign hematologic disease furthermore propose using broader term dermatitis refer disorders although reports interstitial forms cases presentation also published importance diagnosis derives subtype relationship underlying disease elsevier espana slu rights reserved
study introduced sound transmission mechanisms current situation application selective criteria instruments materials summarized major problems instrument manufacturing engineering feasibility artificial board materials alternative material instruments application prospect artificial board materials widely instrument manufacturing materials elaborated study aimed providing scientific theory instrument manufacturing engineering
deformation measurement large measuring deformation monitoring bridge bridge structurally controlled important part long term monitoring diagnosis health article comprehensively analysis contemporary advanced measuring equipment new technology gps global positioning system robots measuring digital close range photogrammetry system advanced reasonable measurement make corresponding data processing software create real time monitoring system large bridges monitoring data analysis management system formed complete bridge suitable large deformation measurement theory techniques ensure normal operation large scale bridge building quality great significance large scale bridge cost high strategic significance many ways transportation military social life predicted next years long span bridge still growth rapidly large scale bridge influenced many aspects construction operation process construction bridge typical time structure close relationship construction technology addition attack corrosion environment dynamic loading vehicle wind damage structure reduce resistance affect service life bridge vigorous development transportation industry bridge load tends increase new structure new materials new technology test technology bridge engineering constantly developing improving increasingly valued people bridge monitoring divided experiment monitoring construction monitoring order study changes bridge measure variety size geometric quantities characteristics large scale example cable stay bridge suspension bridge large span high tower flexibly main span therefore necessary bridge monitoring used special engineering instrument methods
transformation successfully employed several plants genetic modification difficult achieved crops remains still demanding technique engineering agriculture field one major obstacles applying transformation crop plants limited availability suitable selective markers antibiotic ability inhibit protein synthesis best knowledge never reported research transformation yet study aimed use gene selective marker gene tracking transformation rice site specific transformation vector rice constructed expression enhanced green fluorescent protein genes results showed rice plants successfully grew gradual selection resistance integration expression cassette region genome verified southern blotting analysis expression genes identified pcr stable expression cassette rice confirmed confocal microscopy although transformants rice presented status study facilitate development new selective markers improvement transformation efficiency crops
effect studies road vehicle travel focus mostly increases distance increases energy efficiency average speed also increases energy efficiency studies avoid quantifying speed related effects underestimate effects around study offers first attempt show increases speed acceleration contribute effects quantified empirical data test results plug electric car internal combustion engine ice van automatic transmission drive cycles representing driving styles today respectively effects estimated comparing results using typical energy efficiencies electric car shows speed effect mathematical development sets speed effects included traditional effect analyses results ice vehicle allow direct effect estimate due engine wrong gear ratios travel however seen form effect vehicle design drivers fast driving styles elsevier ltd rights reserved
digital technology widely used field implant surgical computer guided surgery utilized enhance primary implant stability improve precision implant placement prosthetic computer aided design computer assisted manufacture cad cam technology brought various options including fabrication customized virtual design based computer guided surgical planning case report describes novel technique combining use three dimensional printed surgical template immediate placement implant cad cam technology optimize hard soft tissue healing bone grafting use
work present efficient implementation canonical monte carlo simulation many body systems graphics processing units gpu method takes advantage gpu single instruction multiple data architectures adopts sequential updating scheme algorithm makes approximation computation energy reaches remarkable fold speedup compared serial implementation cpu use method simulate primitive model measure precisely ion ion pair correlation functions high concentrations data extract length constituent ions dielectric constants results demonstrate physics beyond classical poisson boltzmann theory elsevier inc rights reserved
food eating serve expression social relations roles mechanism sustaining challenging social structure roles also includes reproducing gender roles identities profound social cultural political changes taken place recently poland offers interesting case study changing meaning food gender relationship aim article therefore twofold present available data food choices among men women mostly dietary choices offer sociocultural interpretation data discussing context emerging food regimes recent gender transformations words interested finding food incorporated gender polish context interpreted light scholarly work gender food
presents problems related sensitivity specificity tests present study enzyme linked immunosorbent assay elisa technique used evaluate performance hypothetical protein attempt compare serological reactivity soluble antigenic preparation cutaneous mucosal predicted like protein bioinformatics tools serum samples collected patients disease healthy subjects living endemic non endemic areas also sera collected patients treatments seeking evaluate serological follow relation anti protein anti parasite antibody levels elisa assay performed proved significantly sensitive elisa detecting patients also using sera disease patients elisa proved specific elisa anti protein anti parasite antibody levels also evaluated months treatments treated patients showed significantly lower levels specific antibodies compared anti parasite antibody levels conclusion elisa assay considered confirmatory serological technique infection also used serological follow treated patients aiming correlate low anti protein antibody levels improvement healthy state patients
alleviate increasingly serious water pollution developing countries various kinds policies implemented local governments vital quantify evaluate performance potential economic impacts policies study develops general equilibrium model simulate regional economic environmental effects discharge firstly water resources water environment factors separated input output sources national economic production department secondly extended social accounting matrix sam province developed simulate various scenarios changing values discharge increased three scenarios simulated examine influence overall economy industry simulation results show increased fee negative impact gross domestic product however waste water effectively controlled also study demonstrates along economic costs increase discharge fee lead industrial structures situation heavy pollution one light pollution beneficial sustainable development economy protection environment
main objectives present studies update explicit gender stereotypes linked sport activities examine whether associated gender age personal practice general rates participation study investigate potential effects implicit gender sport stereotypes categorization gendered names study perceptions feminine neutral masculine study study indicated explicit gender stereotypes still attached sport activities little variations according personal characteristics strong association actual rates study focused implicit stereotypes observed slower identification male names participants primed feminine sport activities study neutral frequently categorized women following feminine sport men following masculine sport research suggests sport activities still gendered explicit implicit levels lead individuals adjust participation even outside consciousness
renewable energy sources likely become essential due continuously increasing energy demands together depletion natural resources currently used power generation coal gas also advantageous terms reduced environmental impact generation electrical power vortex induced vibration cylinder investigated numerically cylinder free direction transverse incoming flow cylinder attached magnet move along axis coil made conducting wire magnet coil together constitute basic electrical generator cylinder undergoes motion magnet creates voltage across coil connected resistive load law induced current coil applies force magnet effectively electrical generator applies damping force cylinder spatially varying damping coefficient initial investigation reported reynolds number restricted flow laminar two dimensional incompressible navier stokes equations solved using extensively validated spectral element based solver effects electromagnetic damping constant coil dimensions radius length mass ratio electrical power extracted quantified found optimal value maximum electrical power generated radius length coil increased value observed increase although maximum average power remains larger coil radius length results robust system sense relatively large amount power extracted far unlike constant damping ratio case average power output also function reynolds number primarily increased maximum oscillation amplitude occurs increased reynolds number least within laminar range although general qualitative findings seem likely carry across high reynolds number
technology advances systems involving artificial components provide support people potential consequences phenomena examined specific circumstances ambient assisted living concept intelligent environment chapter describes idea ambient assisted living looks possible ways humans affected prevalence technology general example assisted healthcare specific example medication support used show systems advancing moreover advancements lead problems artificial systems larger systems involved many cases trade around people loop inevitably need included many decision making processes keeping person loop also partially problems artificial general intelligence systems chapter concludes reflections considerations help retain positive aspects whilst avoiding negative side effects hypothetical technological
familial characterized severely elevated low density lipoprotein ldl cholesterol herein identified patient presenting novel compound mutations ldl receptor patient responded modestly maximum plus therapy even combination monoclonal antibody injection using cell biology molecular dynamics simulations aimed define underlying mechanism mutations affect ldl metabolism lead data showed class mutant mostly failed exit endoplasmic reticulum degraded even though similar levels cell surface total receptor bound equally ldl extracellular resistant exogenous mediated degradation showed reduced ldl internalization degradation relative evidence provided association ldl acidic reduced ldl delivery late increased release medium bound internalized ldl compared data suggested loaded ldl findings demonstrate represents loss function novel class causing mechanism thereby observed phenotype
frequently encountered construction deep hydropower station southwest china investigations possibility tunnel machine drilling advancement necessary guide construction protect personnel equipment related accidents real time monitoring system installed forecast locations ahead tunnel faces spatiotemporal distribution evolution events prior recorded analysed concentration events prior occurrence found significant precursor deep rock year investigation deep hydropower station total location forecasts issued correctly forecasting locations successful forecasting locations proved monitoring essential assessment mitigation hazards used minimise damage equipment personnel results current study valuable construction management safety assessment similar underground rock structures high situ stress
solar energy building applications significantly reduce conventional energy consumption related carbon dioxide emissions comprehensive utilization integrated solar thermal photovoltaic systems undoubtedly subject interest present paper optimization model proposed integrated solar energy systems aiming figure optimal utilization economical efficiency solar energy resources buildings cold plateau areas case study city carried order evaluate energy economic performance developed model results indicated solar photovoltaic systems preferred solar thermal systems typical office buildings cold plateau areas rich solar energy resources addition sensitivity analysis performed investigate influences financial commercial electricity prices system economical performance furthermore life cycle assessment conducted compare analyze performances optimization system conventional system elsevier ltd rights reserved
testosterone therapy recommended men symptomatic androgen deficiency low testosterone levels although prevalence hypogonadism seems relatively constant studies prescribing patterns united states united kingdom show dramatic increase testosterone prescription recent years possibly due increased marketing inappropriate therapy concurrent growing concern regarding potential adverse effects testosterone therapy particularly cardiovascular risks review present current understanding implications testosterone deficiency conflicting evidence surrounding cardiovascular effects testosterone replacement therapy although lack adequate data based current evidence conclude testosterone therapy safely considered men appropriately diagnosed clinical androgen deficiency increased cardiovascular risk thorough discussion potential risks guideline recommended safety monitoring
work report design development characterization analytical performances colorimetric smartphone based detection cancer antigen based sandwich strategy primary antibody immobilized onto membrane subsequently incubated solutions followed affinity reaction secondary antibody labeled gold nanoparticles antibody captured onto induced silver deposition silver enhancer solution leading formation gold silver nanoparticles different grey color spots depending concentration smartphone camera integrated home made dark box used transducer color image acquisition data handling pixel intensity captured images determined image processing algorithm experimental parameters involved step design studied optimized obtaining limit detection selectivity immunoassay proven different concentration solutions vascular endothelial growth factor vegf antigen protein signal obtained tested solutions finally preliminary experiments human serum samples spiked protein also performed therefore proposed system represent powerful point care tool next generation technology detecting monitoring cancer biomarkers early stages taking advantage nowadays enhanced features smartphones
dominant view self help remedy individuals alternative seeking state aid words self help consists conduct individuals undertake absent law without assistance government official efforts prevent remedy legal wrong indeed self help often efficient least potentially efficient alternative slower civil justice system world increasingly legal costs meaningful access civil justice system initiated executed without expense merit scholarly attention potential promise legal scholarship self help moreover just behaviour counts self help left unclear self help currently understood risks becoming term cipher almost behaviour initiated individual legal rights count article conception self help recommended dominant view self help self help properly understood alternative civil justice system act vis vis another certain way certain circumstances exist exercise always final determination court self help words equivalent taking law ones hands implied conclusion comfort worry extra legal nature self help ask unilateral action one individual determine scope existence rights another based articles understanding self help simply conclusion however hope self help part solution current access justice crisis true alternative civil justice system costly inefficient remains
engineering design process consists sequence creative innovative routine design tasks routine tasks address known procedures add limited value technical improvement product even require lot work order focus designers work added value tasks present work aims supporting routine task design captures stores design knowledge tool embedded cad software algorithms drive designer selecting effective design concept deliver project requirements concept cad model finally case study definition tool gear design demonstrates effectiveness tool
fungal infections infrequent major complication heart transplantation sought describe epidemiology institution methodsa prospective cohort study heart transplant recipients performed june december defined european organization research treatment cancer study group criteria univariate analysis hispanic ethnicity associated odds ratio confidence interval subsequently multivariate logistic regression performed adjusting hispanic ethnicity age gender seventeen identified occurring median post interquartile range five occurred hospitalization first year incidence conclusionsthe cumulative incidence associated pre post resistant colonization infection post renal replacement therapy anti globulin induction antibody mediated rejection associations diabetes mellitus desensitization cellular rejection treatments rejection operation neutropenia cytomegalovirus infection associated death year mortality year mortality associations hispanic ethnicity validated optimal strategies risk reduction prophylaxis remain undefined
aim parent reporting needed examine quality life qol children cerebral palsy across study examines whether qol changes childhood adolescence predicts adolescent qol method european cohort study children randomly sampled population databases year olds joining study year olds subject report boys girls parent reported qol occasions using transformed scale mean per domain associations assessed using linear regression results childhood adolescence average qol reduced six domains points stable three physical wellbeing autonomy social acceptance socio demographic factors little predictive value childhood qol strong predictor domains adolescent qol severe impairments motor function communication predicted higher adolescent qol domains except severe motor impairment predicted lower adolescent qol autonomy domain psychological problems higher parenting stress childhood worsening adolescence predicted lower qol five eight domains respectively pain seven domains final model explained variance qol depending domain interpretation general impairment severity socio demographic factors predictors lower adolescent qol however pain psychological problems parenting stress predictors lower adolescent qol domains modifiable factors addressing improve adolescent qol elsevier ltd rights reserved
background although available evidence insufficient used patients suffering chronic asthma aim pragmatic study investigate effectiveness addition routine care patients allergic asthma compared treatment routine care alone methods patients allergic asthma included randomized controlled trial randomized receive sessions months control group receiving routine care alone patients consent randomization received treatment first months followed cohort trial patients allowed receive routine care addition study treatment primary endpoint asthma quality life questionnaire range months secondary endpoints included general health related quality life short form range outcome parameters assessed baseline months results total patients mean age years female randomized included analysis patients randomized control group randomized part associated improvement score compared control group difference control group confidence interval physical component scale mental component scale physical mental months treatment success maintained throughout months patients randomization showed similar improvements randomized group conclusions patients allergic asthma additional treatment routine care associated increased disease specific health related quality life compared treatment routine care alone
previous work presented experimental theoretical evidence derivatives substituted atom exhibited significantly elevated potency study series derivatives substituted position including methyl groups synthesized chemical structures confirmed spectral nuclear magnetic resonance nuclear magnetic resonance ionization mass spectrometry elemental analyses derivatives tested respective hela mcf cells mtt assay pharmacological results showed displayed potent least one tested cancer cell lines structure activity relationship study suggested introduction atom enhanced cytotoxicity numerous tumor cells compared atom methyl group furthermore biological experiments consistent beneficial effect atom position inhibited microtubule polymerization activity amino substituted work target proteins induce dependent apoptosis
planar cell polarity pathway best known role epithelial cells within plane tissue also plays role range cell migration events development mechanism pathway stationary epithelial cells characterized signaling functions regulate dynamic cell behaviors directed cell migration much less understood review recent discoveries regarding localization proteins cells impact cell biology collective individual cell migratory behaviors
goal study evaluate potential relationship among polymorphisms aromatic hydrocarbon receptor aromatic hydrocarbon receptor rheumatoid arthritis susceptibility association among polymorphisms aromatic hydrocarbon receptor aromatic hydrocarbon receptor expression performed hospital based case control study patients healthy controls han chinese populations two single nucleotide polymorphisms selected genotyping including aromatic hydrocarbon receptor aromatic hydrocarbon receptor single nucleotide polymorphism statistically significantly increased risk found associated allele odds ratio confidence interval unfortunately significant differences exhibited allelic genotype frequencies groups failed find association genotypes expression patients respectively statistical relationship found aromatic hydrocarbon receptor aromatic hydrocarbon receptor messenger acid levels clinical data either study demonstrated polymorphisms significant genetic susceptibility patients furthermore suggests allele associated dangerous effect han chinese populations
preference based approach proposed grid computing regard preferences given various groups virtual organization stakeholders users resource owners administrators improve overall quality service resource load efficiency specific cyclic job batch scheduling scheme examined performs job flow balancing stakeholders conflicting preferences policies two different metrics introduced find scheduling solution balanced stakeholders additionally two job batch procedures proposed establish equality scheduling jobs different preferences types
herbal medicines long used treat parkinsons disease systematically analyze anti activity model provide future basis basic clinical investigations male mice randomized control model administration groups significantly suppressed dopaminergic neuron loss caused maintained dopamine content dopamine metabolite content compared measured mice methyl phenyl induced damage additionally inhibited activation microglia astrocytes substantia nigra suggested involvement neuroinflammation relevant cytokines detected proteome array confirmed participated regulation seven cytokines given protein kinase kappa signals considered closely related gene expression levels six kappa dna binding subunits assessed western blotting analysis showed kappa subunit upregulated group downregulated expressions administered positive control inhibit neuroinflammation differences detected mediated inhibition kappa signals conclusion potential novel orally active compound regulating neuroinflammation related signals parkinsons disease provide new prospect clinical treatment
recently relationship fracture surface roughness materials strength received much attention literature paper image used novel economic tool characterize fracture surface roughness steel fiber reinforced concrete main purpose study investigate effect steel fiber content concrete design mix surface roughness direct tensile tests carried dog bone shape specimens constant size fracture surface specimens fracture trajectory list pixel numbers extracted using image analysis techniques fractal dimensions calculated based box counting algorithm via computational code finally validate results applied formulations discrete fractal fracture mechanics published accordingly estimation ratio quantum fracture step maximum size given describe relationship design strength fracture roughness also steel fiber effect formation surface trajectory discussed according image analysis results correlation matrix significant parameters study presented concluded image analysis economic accessible method surface roughness characterization elsevier ltd rights reserved
since eddy current problem usually depends geometry moving conductive sheet pole shape general method find analytical solution analyses eddy current rotating disk ones extended array performed case time invariant field find approximate analytical solution method solve eddy current problem firstly concept law mapping technique introduced consideration boundary condition secondly induced magnetic flux density calculated lumped way using law net magnetic flux density defined introducing magnetic reynolds number ratio induced magnetic flux density applied magnetic flux density analyses extended system extended array two finally braking torque calculated applying lorentz force law computed result compared experimental one
worldwide lethal frequent intracranial tumor despite decades study overall survival patients remains unchanged epidermal growth factor receptor egfr amplification gene mutation thought negatively correlated prognosis study used proteomics determine negative downstream regulator egfr mutation via bioinformatics analysis found factor improve glioma patients overall survival time also determined regulation mediated upregulation presence kappa negatively regulated believe activates kappa suppressing expression importantly used latest genomic editing tool knockout exon proved negatively regulated furthermore knockout egfr benefit vitro vivo indicating promising therapeutic strategy egfr amplification egfr mutation bearing patients elsevier ireland ltd rights reserved
statistically valid reasons scientists differing default hypotheses high profile situations examples found recent correspondence journal offer lessons resolving challenges mainstream science particularly minority view attempt status studies claim self interest explains acceptance dominant theory historical origins linear threshold theory carcinogenesis use regulation radiation charged committee scientists preparation report genetic effects atomic radiation specifically argues report research record suppressed calculations committee members reviewing available scientific literature found evidence favored genetics calculations suppressed claims scientific record hold primarily lack attention statistical analysis studies likely favor linearity sub linearity finally claim bias underlies key studies based text attention ethics charges early help seed counter narrative explaining adoption default hypothesis help focus attention valid evidence real weaknesses dominant paradigm
two promoter probe plasmid vectors designated constructed existing plasmids use gene pseudomonas reporter transferred conjugation escherichia coli function plasmids promoter probes demonstrated using synthase promoters activity detected colonies agar plates via vitro assay integration chromosome constructs containing promoter verified southern blotting presence locus allows recovery putative promoters marker rescue elsevier inc rights reserved
article describes brief treatment mexican american presented family therapy address major depressive disorder mdd comorbid binge behaviors treatment brief integrated components family based therapy narrative therapy overarching lens progress measured self report childrens depression inventory parent report concrete behavioral markers reduced number events end treatment reduction depressive symptoms elimination suicidal ideation cutting behaviors reduction fatigue low mood disrupted eating behaviors supporting family identify leverage individual family strengths treatment also strengthened family communication increased shared positive family experiences family meals supported engaging community activities consistent values case adds existing literature reviewing ways treatment modified across multiple domains provide culturally sensitive care identifying weaknesses approach serve illuminate gaps existing literature highlight areas clinicians want adapt treatment strengthen client outcomes
hydrological connectivity describes physical coupling linkages different elements within landscape regarding sub surface flows firm understanding hydrological connectivity important catchment management applications example habitat species protection flood resistance resilience improvement thinking systems networks lead new insights also recognized within scientific community seeing recent increase use network graph theory within network theory supports analysis understanding complex systems providing data structures modelling objects linkages versatile toolbox quantitatively network structure properties objective study characterize quantify flow connectivity dynamics humid sub mediterranean environment using combination high resolution digital terrain models flow sensors network approach results showed significant differences flow connectivity agricultural areas semi natural areas significant positive correlations connectivity precipitation characteristics found significant negative correlations connectivity soil moisture found likely soil water soil surface combination structural networks dynamic networks determining potential connectivity actual connectivity proved powerful tool analysing flow connectivity copyright john wiley sons ltd
non relational databases recently preferred choice comes dealing challenges performance sensitive chosen data organisations seen differences times response time query different models brings users need fully conscious queries serve order design data model common practice replicate data different models designed fit different query requirements scenario user charge code implementation required keep consistency different data propose design mechanism prototype provide users transparent management queries matched performing model option additionally propose transforming replication mechanism heterogeneous replication one order avoid disk space keeping availability reliability features
purpose review new risk stratification systems treatment strategies introduced recent years aim provide overview recent changes data concise article useful clinicians recent findings apart clinical stage disease genetics now recognised important prognostic risk factors various new cytogenetic changes negative prognostic impact identified new technologies minimal residual disease detection also playing important role prognostic assessment recent introduction combination therapy proteasome inhibitors immunomodulatory drugs showing promising results high risk patients partially negative impact associated adverse risk factors summary recent advance improved understanding high risk multiple new therapeutic agents now coming pipeline patient group outcome
paper based multi generation energy system including organic rankine cycle domestic water absorption refrigeration cycle proton exchange membrane developed generate electricity heating cooling hydrogen purpose energetic analysis undertaken upon proposed system also effects important variables water temperature turbine inlet temperature pressure generator temperature water mass flow rate current density several parameters energy exergy efficiencies proposed system heating cooling load net electrical output power hydrogen production unit cost system products total unit cost products investigated specified conditions results show energy exergy efficiencies proposed system calculated respectively highest lowest total unit cost products estimated approximately respectively considering water temperature increases degrees degrees published elsevier ltd
although patients diabetes times increased risk cardiovascular morbidity mortality individuals without diabetes recent studies indicate significant part patients lower cardiovascular risk category men younger years women younger years patients diabetes duration less years without risk factors much lower risk patients traditional cardiovascular risk factors subclinical established coronary artery disease cad patients risk equivalent stated previous studies contrary presence traditional risk factors evidence subclinical coronary disease high coronary calcium score coronary risk much increased patients classified higher risk category recent guidelines consider diabetes cad risk equivalent recommend cardiovascular risk stratification primary prevention stratification diabetic patients improves accuracy prediction subclinical cad silent ischemia future cardiovascular events stratification also higher lower risk patients need intensive aspirin prevention avoiding lower risk cases also allow clinician decide whether risk reduction actions specific newer drugs glucose control inhibitors agonists recently shown additional cardiovascular effect review addresses assessment cardiovascular disease risk using traditional non traditional cardiovascular risk factors also reviews use risk new tools focusing detection subclinical atherosclerosis silent ischemia asymptomatic patients diabetes
study displacement blocking force tip point electro active polymer actuator controlled cell injection process consists approaching interacting leaving steps vision based system used acquire tip displacement data identifying transfer function model actuator position control discrete time proportional integral controllers used control position blocking force predictor utilized vision based position control system compensate time delay due image processing experimental position blocking force results prove proposed control strategies effective enough guide actuator undertake cell injection process study contributes previously published work point view simultaneously controlling position blocking force polymer actuators application areas
services provides comprehensive services solutions field petroleum course working various assignments fundamental principles design rotary systems resulting evolution paper important process criteria design retention time heating rate operating factors depend dimensions slope heat transfer rate air injections understand worked mass heat balance across mechanical design consider load factors thermal expansions strength materials elevated temperatures ensure mechanical protection distortion refractory design take account differential thermal expansion coefficients ability high temperatures resistance chemical attack good
article reviews effects restrictive eating disorders bone health relationship eating disorders discussed detail pathologic impact malnutrition bone explored examining results studies using various available imaging techniques multiple hormonal alterations seen adolescents young women anorexia nervosa reviewed alterations influence bone turnover density structure strength diagnostic clinical evaluation adolescents young women disorders also outlined available treatment options including hold promise efficacy deemed ineffective considered clinical mechanistic finally future research opportunities offered including intriguing work area fat bone interactions
background incidence spinal estimated per patients per year classified idiopathic spontaneous secondary cause spontaneous uncertain associated minor trauma surrounding structures shown clinical symptoms signs affect spinal cord nerve roots surgical treatment considered medical treatment fails case description year old man presented lower back pain significant symptoms left side week previous lumbar trauma use anticoagulation drugs used full endoscopic approach technique remove local anesthesia patient discharged home days surgery pain disappeared completely three months later follow magnetic resonance imaging showed dark brown lesion totally removed conclusions spontaneous uncommon although lumbar mainstream treatment neurologic deficits caused percutaneous full endoscopic approach option certain
web based antibody research system includes integrated database antibody sequence structure data system numerous ways simple text sequence searches sophisticated queries apply structural constraints publicly available version includes pre analyzed sequence data european molecular biology laboratory european nucleotide structure data protein data bank researchers sequences also analyzed web interface defining characteristic sequences automatically series popular schemes annotated key information determining regions potential post translational modifications unique aspect set residue frequency tables position antibody allowing unusual residues rarely seen particular position highlighted decisions made mutations acceptable especially useful comparing antibodies different species useful researcher antibody engineering especially developing antibodies drugs available published elsevier ltd
containing acid known target alpha beta tumor angiogenesis generic kit procedure different generators developed evaluated versatile use safety subsequent vivo applications kit verified expected pharmacokinetics primates clinical sensitivity detect solitary pulmonary nodules cancer patients single kits containing nmol asp sodium acetate buffer formulated versatility performance based generator type characterization long term storage stability kits carried blood clearance urine recovery kinetics image guided studied model kits tested clinically target solitary pulmonary nodules kits successfully formulated integrity months good performance purity decay corrected yield specific activity mol kits met quality requirements tested vivo rapidly blood excreted via renal route liver spleen heart showed initial uptake steadily declining tissue activity concentration time addition kit allowed non malignant lung tissue humans versatile procedure using kit formulated different generator types achieved vivo behavior efficient targeting warrants investigations clinical relevance derivatives implement initial guidelines management patients regard integrin targeted imaging
drawing upon social cognitive domain theory self determination theory goal present multi informant study test whether correlates maternal depend content social domain involved thereby contrasting moral friendship communicated thereby contrasting autonomy supportive controlling communication style sample adolescents mean age years female mothers mean age years first examined mean level differences two domains terms mothers degree style number developmental outcomes adolescents perceptions internalization oppositional adolescents mothers reported maternal involvement moral domain higher scores degree controlling communication style addition adolescents reported greater perceived less oppositional moral domain compared domain second tested whether associations degree style developmental outcomes moderated social domain whereas associations degree developmental outcomes either non significant moderated domain associations communication style domain invariant autonomy supportive style generally yielding adaptive pattern correlates controlling style relating maladaptive outcomes discussion focuses similarities differences characteristics correlates types
recombinant associated virus vectors proving reliable gene transfer system several clinical applications increasing body evidence supporting safety efficacy realizing clinical commercial potential depends reliable source high quality characterized lots requirement challenging achieve due limits manufacturing platforms lot lot variability differences applied quality control assays addition reliable high quality vectors limited quantities hampered clinical development investigations applications require large therapeutic doses quantities needed treat large patient populations minimal number vector production runs sufficient support phases clinical development including non clinical pharmacological toxicological studies clinical studies commercial supply production platform using cell line emerged scalable economical source access larger quantities now enabled evaluation gene therapeutics diseases require large doses per patient diseases large patient populations licensed product produced cells products clinical trials united states europe development genetics processes overview current system described
family planning association contraceptive study includes women initially aged years recruited british family planning centers interval subsequently followed periods years article examines pattern referral hospital back disorders among women certain back disorders reported occur frequently oral contraceptive users women back pain also reported women consequent using intrauterine device disorders considered spinal osteoarthritis cervical disc lumbar disc disc back pain sprains strains back spinal osteoarthritis two conditions significantly related positively age lumbar disc disc strongly positively related height weight showed similar less striking terms magnitude relative risks associations height weight little evidence found association oral contraceptive use back disorders true intrauterine device use contraception elsevier science inc rights reserved
treatment diseases gene therapy advancing rapidly use gene therapy expanded original concept replacing mutated gene causing disease use genes control levels expression modify pathways known affect disease genes offer numerous advantages conventional drugs longer duration action specific genes delivered target site dna cells viral vectors enormous progress past decade molecular biology delivery systems provided ways targeting genes intended cell tissue safe long term vectors eye ideal organ gene therapy easily accessible immune site currently clinical trials diseases affecting practically every tissue eye including restore vision patients congenital however number eye trials compared systemic diseases quite low nevertheless judging vast amount ongoing preclinical studies expected number increase considerably near future one area great need eye gene therapy long term gene drug eliminate daily applications compliance issues review current state gene therapy possibilities treating trabecular lower pressure retinal ganglion cells protect neurodegeneration
introduction neuropsychiatric symptoms nps alzheimers disease associated significant negative outcomes patients caregivers one nps lacks safe effective long term interventions interventions suggested first line treatment effective every patient resulting pharmacological interventions patients consisting label use antipsychotics acetylcholinesterase inhibitors antidepressants efficacy necessarily associated covered gains understanding neurobiological mechanisms underlying several recent clinical trials article updates review published comprehensive literature search published articles january december evaluating pharmacologic interventions done review several clinical trials completed show promise treating opinion neurobiological findings innovative trials designs statistical approaches preliminary paths regulatory agency acceptance area pharmacological treatment nps though research needed fully determine safety tolerability efficacy treatments mission find effective treatments neuropsychiatric symptoms patients dementia underway
longitudinal links early childhood temperament maternal sensitivity adolescents adjustment proposed found several longitudinal studies mechanisms influence explored authors examined paths maternal sensitivity temperament early childhood adolescents prosocial aggressive behaviors via childhood social behaviors peer group affiliation data months grade age grade age grade age longitudinal investigation participants boys analyzed overall results yielded evidence maternal sensitivity child temperament months age predicted prosocial aggressive outcomes age affiliation peer groups especially prosocial peers social behaviors childhood mediated aforementioned paths control maternal sensitivity discussion focuses implications understanding long term effects early childhood predictors behavioral outcomes adolescence
consider problem design implement communication efficient versions parallel kernel support vector machines widely used classifier statistical machine learning distributed memory clusters main computational bottleneck training phase statistical model built input data set prior study parallel state art implementation scaled omega problem size number processors scaling worse even one dimensional block row dense matrix vector multiplication omega study considers series algorithmic leading ultimately communication avoiding svm method improves nearly omega evaluate methods processors show average average percent weak scaling efficiency six real world datasets modest losses overall classification accuracy source code downloaded
wall youth versus adult injuries presenting united states emergency rooms accidental versus injury mechanisms strength res resistance training previously unsafe ineffective children purpose investigation evaluate resistance training related injuries presenting emergency rooms age type mechanism injury hypothesized older athletes sustain greater percentages joint sprains muscle strains whereas younger athletes sustain greater percentage accidental injuries result increased percentage fractures youths consumer product safety commission national electronic injury surveillance system using code subjects ages grouped age categories elementary middle school age high school college adult injuries classified accidental caused dropped weight equipment use multiple logistic regression used compare accidental injuries age groups sample consisted patients accidental injuries decreased years years conversely strain injuries increased successive age group evaluation injuries showed oldest categories demonstrated greater percentage sprains strains relative younger age categories two thirds injuries sustained group hand foot often related injury descriptions increased percentage fractures group relative groups study findings indicate children lower risk resistance training related joint sprains muscle strains adults majority youth resistance training injuries result accidents potentially preventable increased supervision safety guidelines
background graph based hierarchical clustering algorithms become costly execution time storage space number nodes approaches order millions objective fast highly memory efficient markov clustering algorithm proposed perform classification huge sparse networks using ordinary personal computer methods improvements compared previous versions achieved adequately chosen data structures facilitate efficient handling symmetric sparse matrices clustering performed two stages initial connected network processed sparse matrix breaks isolated small relatively dense processed separately convergence obtained intelligent stopping criterion also proposed quit processing tends toward completeness equal edge weights main advantage algorithm necessary number iterations separately decided graph node results proposed algorithm tested using large synthetic protein sequence data sets validation process revealed proposed method reduce times processing time huge sequence networks compared previous markov clustering solutions without losing partition quality conclusions one million node one billion edge protein sequence network defined blast similarity matrix processed upper class personal computer minutes improvement speed possible via parallel data processing extension toward several million nodes needs data storage example solid state drives elsevier ireland ltd rights reserved
infer candidates political orientations faces report evidence observers make systematic judgment errors political views attractive competent looking candidates subjects judged images student candidates running university experiment professional politicians state germany experiment according whether person displayed held views prediction accuracy chance level experiments candidate attractiveness experiment perceived competence experiment increased subjects likelihood political views candidate findings suggest value face based inferences choosing candidate best represents ones views limited previously assumed also suggest good looks help candidates presenting moderate
paper proposes nonparametric variable step size least mean absolute third algorithm improve capability adaptive filtering algorithm impulsive noise types noise step size obtained using instantaneous value current error estimate posterior error estimate approach different traditional method nonparametric variance estimate algorithm fewer parameters need set thereby reducing complexity considerably additionally mean additive noise necessarily equal zero proposed algorithm addition mean convergence steady state mean square deviation algorithm derived computational complexity analyzed theoretically furthermore experimental results system identification applications presented illustrate principle efficiency algorithm
background hypertrophic cardiomyopathy patients early pattern higher risk ventricular arrhythmia yet genetic background situation investigated report novel mutations detected chinese family obstructive short syndrome methods family members underwent detailed medical assessments extracted peripheral blood leukocytes genetic screening next generation method functional characterization mutation conducted cells patch clamp experiment results year old male pattern ecg lateral leads block also suffered severe left ventricular hypertrophy dysfunction targeted sequencing revealed mutations des mutations also detected mild hypertrophy mutation caused significant reduction compared computer modeling showed mutations highly disease causing received cardiac therapy implantation lowered left ventricular outflow tract gradient mmhg pre mmhg post restored function pre post conclusions study reveals novel mutation underlying unique pattern also shows rare mutations pathogenic substrates complicated clinical manifestation patients
angioedema rare inherited type physical urticaria characterized acute onset mucosal cutaneous edema triggered vibration report case year old woman elicited use dental equipment knowledge first report induced mechanical dental equipment
liquid allergen immunotherapy used label decades food drug administration fda approved grass tablets available united states since potentially life threatening events occur although appear rare especially fda approved products practice guidelines incorporate safety regarding use united states needed clinical commentary attempts address unresolved issues including controversy regarding fda prescription patients approach patients optimal timing duration administration address gaps therapy whether prevent local reactions certain patient populations persistent receive patients self key points physicians focus educating patients regarding recognize potentially serious allergic reaction seek emergency care american academy allergy asthma immunology allergy
development transition state analogs major objective enzymology developing potent inhibitors enzymes also enzyme catalytic mechanisms peptides share closed structural similarities transition state peptide substrate upon hydrolysis thus considered identifying potent inhibitors proteases focusing zinc proteases family review presents important synthetic efforts performed obtain desired compounds crystal structures peptides interaction zinc protease targets reported illustrate structural features explain potency compounds contribute uncover key enzyme catalytic residues based remarkable metabolic stability peptides used probe vivo function zinc proteases progress chemistry better understanding functional roles zinc proteases allow transferring compounds shelf clinic
background thyroid disease pregnancy common clinical problem since guidelines management disorders american thyroid association first published significant clinical scientific advances occurred field aim guidelines inform clinicians patients researchers health policy makers published evidence relating diagnosis management thyroid disease women pregnancy postpartum period methods specific clinical questions addressed guidelines based prior versions guidelines stakeholder input input task force members task force panel members educated knowledge synthesis methods including electronic database searching review selection relevant citations critical appraisal selected studies published english language articles eligible inclusion american college physicians guideline grading system used critical appraisal evidence grading strength recommendations guideline task force complete independence competing interests guideline task force members regularly updated managed communicated task force members results revised guidelines management thyroid disease pregnancy include recommendations regarding interpretation thyroid function tests pregnancy iodine nutrition thyroid autoantibodies pregnancy complications thyroid considerations women hypothyroidism pregnancy pregnancy thyroid nodules cancer pregnant women fetal neonatal considerations thyroid disease lactation screening thyroid dysfunction pregnancy directions future research conclusions developed evidence based recommendations inform clinical decision making management thyroid disease pregnant postpartum women care individualized recommendations provide opinion optimal care paradigms patients disorders
prospectively investigate affects diagnosis bowel inflammation diffusion weighted imaging crohns disease thirty patients without previous bowel surgery underwent sec intravenous patients randomly divided two groups using crossover design interpretations made regarding presence restricted diffusion bowel inflammation nine bowel segments two separate reading sessions two readers readers also judged restricted diffusion extent bowel segment two side side images random right left order conventional interpreted expert panel reference standards analyzed bowel segments without significantly decreased sensitivity readers significantly increase specificity two readers noted bowel segments greater diffusion restriction extent compared without respectively similar extent caused greater loss sensitivity false positive reduction diagnosing bowel inflammation cent significantly decreases sensitivity diagnosing bowel inflammation cent increase corresponding specificity less apparent cent without extent bowel inflammation
photos lead people believe true false events happened even photos provide evidence events occurred research shown photos increase false beliefs combined misleading suggestions repeated exposure photo target event propose photos exert similar effects without factors test five experiments experiment people saw names several animals give food take food people saw animal names half photo animal half alone decided whether experience photos led people believe experiences animals moreover experiments provided evidence photos exerted effects making easier bring related thoughts images mind feeling people evidence genuine experience experiment photos led people believe positive claims past negative claims consistent evidence feelings ease selectively increase positive judgments experiment also showed photos like manipulations ease bias peoples judgments broadly producing false beliefs peoples finally experiment photos exerted powerful effects depicted unfamiliar animals thus help bring information mind findings suggest photos past without factors encourage false beliefs operate helping related thoughts images come mind
magnetorheological shear thickening fluid smart material exhibits magnetorheological shear thickening effects study focuses design development novel magnetorheological shear thickening fluid based linear damper first sized carbonyl iron particles weight fraction immersed among shear thickening fluid base thoroughly mixed high shear condition produce magnetorheological shear thickening fluid damper bypass designed fabricated testing results using machine show influence incorporating shear thickening fluid allows magnetorheological shear thickening fluid filled damper work different dynamic loading velocities stiffness damping changed simultaneously dynamics damper depend variations magnetic field measured responses magnetorheological shear thickening fluid filled damper prove effect shear thickening effect contrast magnetorheological shear thickening fluid filled damper behaves like conventional magnetorheological fluid filled damper shear thickening effect effect becomes obvious higher iron volume
introduction study examined potential feasibility delivered parent coaching rural area italy survey parents attitudes towards type intervention methods parents children six years age registered diagnosis autism spectrum disorder clinic area invited take part study final sample consisted parents results parents worse internet skills reported lower levels satisfaction currently received services less likely willing trend parents lower self efficacy less likely educational level previous experience video calling travel time clinic childs level ability associated choice discussion implications strategies contrast barriers adoption strengthen implementation plans discussed
article proposed new scheme highly image pixel data existing literature single substitution used break images get better results instead single substitution box researchers minimizing via utilizing multiple substitution boxes however found multiple substitution boxes solve problem independently therefore added chaotic confusion diffusion existing substitution scheme order remove correlation completely initially break data pixels via chaotic map carried diffusion using logistic map followed existing substitution scheme experimental analysis shows proposed scheme greater resistance force attack statistical attack analyses statistical analysis peak signal noise ratio contrast analysis key space analysis entropy analysis correlation analysis key sensitivity analysis encryption quality analysis proved high robustness proposed scheme
commonly known active components shown several useful pharmacological effects antidepressant anti inflammatory antitumor radical effects learning memory improving effects etc increasing body data use medical databases within last years current review strengths weaknesses clinical trials different pharmacological effects discussed extract studied antidepressant clinical trials comparison placebo antidepressant drugs showed effectiveness antidepressant drug clinical trials anti alzheimer effect demonstrated effective placebo effective clinical trials promoter skin care effects confirmed efficient placebo another clinical trial proved addition weight loss treatment reduce frequency clinical trials conducted women syndrome showed reduce suffering symptoms placebo similar standard treatments furthermore additional clinical trials effects dysfunction allergies cardiovascular immune system safety toxicity human pharmacokinetics reviewed herein
previous works presented experimental investigations brittle material removal fraction surface optical glass related area fraction brittle material removed surface used assess surface roughness optical glass precision general subsurface damage considered one important machining qualities optical glass work presents experimental investigation relationship depth optical glass precision understand significance sensing optical glass series precision experiments conducted precision machine investigate influence parameters depth based image processing algorithm developed previous work calculated using image surface glass precision experimental results show determined different machining parameters cutting depth wheel speed feed rate dependent depth precision implies potential application rapid affordable online vision measurement approach monitor surface subsurface qualities brittle materials
ability solve complex problems essential skill construction project manager possess entering architecture engineering construction industry ability requires mixture problem solving skills composed lower higher order thinking skills include ability develop evaluate construction plans manage execution plans however introducing students complex problems challenge typical construction educational program support challenge traditional methodology delivering design engineering construction instruction going technological revolution due rise computer based technology example engineering classrooms disciplines educational simulation games used support development problem solving skills paper presents evidence support educational simulation games help learning retention problem solving skills crucial solve complex construction problems sample group architectural engineering students year construction class participated quasi experiment play three modules virtual construction simulator repeated measures quasi experimental design assessed gains problem solving skills construction students gained playing participants completed three learning modules assessed treatment based series analyses results researchers able conclude students gained transferred problem solving skills playing modules study provides evidence implementation educational simulation games support gain problem solving skills necessary solve complex construction problems
environmental challenges posed global warming region include early rapid melting creation new lakes expansion old ones high risk lakes flood hazard downstream communities according various elevation ranges lakes analyzed ranges pakistan using remote sensing data period overall increase lakes observed various ranges noticeable change number within range analysis carried fed lakes different river basins indicated variable patterns depending geographic location region correlation analysis parameters like lake area expansion rate elevation performed lakes distributed various river basins three ranges lake area elevation showed negative relationship basins except correlation expansion rate lakes elevation positive side basins situation attributed variable pattern temperature precipitation order explore diverse patterns lake behavior relationship influential factors detailed studies based using high resolution image data coupled situ information prerequisite although increase lake area observed favorable water resource management context flood hazards need monitored critically long term basis elsevier rights reserved
large increase number brazil added current concern reduce use natural resources preference consumers companies adopt environmental measures management plans rainwater harvesting system become increasingly common various levels infrastructure country following paper review current legislation deals regulation use rainwater harvesting system bringing international examples beyond brazilian legislation specifically aimed subject paper also brings legislation proposal encourages management rainwater part projects way enhance competitiveness reduce costs contribute rational efficient use water resources reducing volume water discharged municipal drainage system
causative agents affects production various parts world however safe effective drug currently available treatment dehydrogenase fourth enzyme novo synthesis pathway known novel drug target several parasites study evaluated four inhibitors hydroxy growth vitro compared control drug growth significantly hindered inhibitors except half maximal inhibitory concentration approximately respectively whereas approximately respectively using bioinformatics western blot analysis showed similar parasite confirmed targeting useful development novel treatment elsevier inc rights reserved
literature documented significant relationship borderline symptoms substance use disorders supported past work significant theoretical relationship borderline symptoms compulsive sexual behaviors disorders share common underlying behaviors traits known research examined empirical relationship borderline symptoms compulsive sexual behaviors population substance use disorders fill important gap literature relationship examined current study records women admitted private residential treatment program substance use disorders reviewed current study multiple regression analysis demonstrated borderline symptoms significantly associated compulsive sexual behaviors controlling alcohol use problems drug use problems age positive impression management study provide potentially important research clinical implications ultimately aid treatment reduce relapse however continued research needed examine relationship symptoms compulsive sexual behaviors
context emergency contraception widely used prevent unwanted pregnancy largely adopted many countries counter drug improve access aims determine compare correct knowledge attitude current use among newly medical doctors mds settings design cross sectional study conducted among newly mds university college hospital nigeria materials methods self administered questionnaire used obtain data participants statistical analysis used descriptive bivariate multivariable analyses performed statistical significance set statistical package social science version usa software used results mean age respondents years standard deviation commonest indication emergency contraceptive use mentioned support nigeria quarter routinely women use respondents currently use logistic regression analysis revealed significant results gender odds ratio confidence interval religion marital status conclusion correct knowledge professional disposition toward form contraception low recommend service training focus improve quality knowledge attitude towards
two experiments examined false memory lists associates two meanings trip harvest etc upon single ambiguous critical fall order compare activation monitoring fuzzy trace false memory accounts experiment presented study lists blocked meaning within subjects followed free recall test completed immediately min delay correct recall greater blocked lists critical false recall greater blocked lists immediate test whereas list types produced equivalent false recall delayed test experiment lists blocked meaning presented via subjects design order eliminate possible list type effects correct recall replicated result experiment however blocking lists increased false recall delayed immediate tests across experiments clustering correct recall meaning increased across delay selectively lists results suggest thematic processes influential false recall especially following delay pattern consistent fuzzy trace theory
terms often used appears researchers many disciplines comprising continue trend problem seems research advanced studies psychopathy common two terms psychopathy now much specific definition language serve hinder research crucial terms take proper place brain science present two terms currently used neuroscience psychology suggest research progress elsevier ltd rights reserved
variety contraception options available addition traditional combined oral contraceptive pills newer long acting reversible contraceptive methods intrauterine devices subcutaneous implants preferred depend patient compliance highly effective appropriate women female male sterilization effective irreversible require counseling minimize contraceptive injection patch ring require daily administration typical efficacy rates lower methods similar combined oral contraceptive pills
background breast cancer common malignancy remains leading cause cancer related deaths female chemotherapy failure breast cancer mainly associated multidrug resistance cancer cells purpose modified anti resistant developed multidrug resistance eliminating cancer cells methods modified surface increasing intracellular uptake inserted phospholipid reversing cancer drug resistance encapsulated aqueous core anticancer agent evaluations performed mcf cells cells mcf cells results vitro results showed modified anti resistant exhibited suitable physicochemical properties significantly increased intracellular uptake mcf cells mcf cells multidrug resistance via inhibiting vivo results demonstrated targeting showed long effect blood system remarkably accumulate tumor location involved action mechanisms enhanced anticancer efficacy activation pro apoptotic proteins bax apoptotic enzymes caspase caspase caspase conclusion established modified anti resistant provide potential strategy treating resistant mcf breast cancer
digital content makes improvement learning transferring knowledge learners learning delivers digital contents learners learn anywhere educators deliver materials interactive way digital content becomes important improving self learner understanding computer programming experimental design method using control group pretest posttest conducted compare digital contents effectiveness learning outcomes computer programming field self learning students instrument used programming case factor level tested various digital content types desired response learning outcomes increment study concludes average increment learning outcomes using various digital contents self learning still lower average increment compared traditional classroom method results study recommendation educators students applying determining use digital contents self learning
age related male hypogonadism increasingly recognized frequent occurrence older patients diagnosis requires presence clinical symptoms low testosterone levels however diagnosing age group challenging since symptoms frequently non specific testosterone levels influenced multitude parameters lifestyle factors chronic diseases article discuss pathophysiology definition diagnostic difficulties geriatric patients moreover review relation testosterone levels frequent geriatric syndromes falls osteoporosis cognitive mood disorders anemia cardiovascular disease finally examine potential benefits risks testosterone replacement therapy age group elsevier ireland ltd rights reserved
paper describes use create interactive applications part useful usable project applications transform historical climate data knowledge models decision support tools end users crop farmers university extension educators agricultural creating support project four major challenges addressed designing developing highly usable web applications frequent feedback establishing software engineering environment support iterative development integrating synthesizing historical current datasets variety sources local remote different access methods formats supporting project collaboration needs data document sharing project management public outreach overall goals architecture design described methods data retrieval synthesis various software components utilized discussed development integration tools collaborative framework highlighted including use core features share ideas algorithms results highly iterative development process includes feedback experts end users feed requirement definition design application updates also examined authors published elsevier open access article license
binary euclidean algorithm modification classical euclidean algorithm computation greatest common avoids ordinary integer division favour division powers two expectation number steps taken binary euclidean algorithm applied pairs bounded size first investigated via heuristic model algorithm random dynamical system based numerical investigations expectation associated transfer operator obtained asymptotic expression mean number steps performed algorithm processing pairs odd whose size bounded large integer modified model via induction scheme rigorously prove asymptotic formula average number steps performed algorithm however relationship result heuristics remains article establish previously properties transfer operator showing directly possesses spectral gap preserves unique continuous density density shown extend complex right half plane zero combining results methods classical analytic number theory prove correctness three formulae expected number steps resolving several open questions promoted art computer programming author published elsevier inc
many projects face senior management fear run project success take turn worst project manager replaced result transfer replacement leader foundation project result poor management triple constraint scope time budget loss historical project information cause ripple effect conflict confusion poor team within project team term replacing project manager rpm easily recognized organizations yet little documentation available discussing common issue frequency replacement circumstances project manager replaced effect project execution investigated
chronic venous disease cvd common venous disease lower extremities patients often develop symptoms skin roughness easy use objective skin examination recently developed allows measurement level stratum content water loss indicate status barrier function stratum previous studies demonstrated histamine production mast cells matrix levels associated skin inflammation study aimed clarify relationship dry skin inflammatory mediators mediate skin symptoms cvd subjects study enrolled subjects cvd control group consisting volunteers onset frequency higher women compared men analyze mechanisms involved measured blood inflammatory mediators pre post significant decrease substance histamine ige levels post compared pre levels associated severity addition compared control subjects significant increase stratum water content decrease patients cvd associated decrease symptoms findings indicate decreased levels inflammatory mediators increased stratum water content decreased reduced cvd patients indicating therapeutic targets
study left atrial structure morphology assessed using real time three dimensional echocardiography enhanced cardiac computed tomography scanning two measurements obtained using different techniques compared two hundred atrial fibrillation patients prepared undergo ablation enrolled controls enrolled prospectively performed following parameters measured diameter area depth maximum volume velocity differences patients controls compared differences correlations parameters two imaging techniques assessed patients significantly bigger sizes areas maximum volumes lower rates cohort roughly equal proportions four morphological types whereas controls predominantly type analysis demonstrated measurements obtained using lower obtained however linear regression analysis showed good correlations measurements area depth volume respectively use visualization quantitative analysis parameters feasible obtained measurements correlate obtained cardiac technique ideal tool guiding occlusion procedures combining two methods enhance accuracy measurements
doped carbon materials great potential functional materials water pollution control however synthesis green sustainable doped carbon catalysts face numerous challenges study uses thermal treatment directly heating homogeneous mixture cobalt acetate synthesize ordering compounds chosen play roles nitrogen carbon source obtained doped carbon material used catalyst effective degradation activating approach nanomaterials good catalytic performance high stability magnetic property obtained facilitate convenience study found improve electron mobility pair like electrons tends form effective moieties species increase catalyst activity therefore prepared catalyst higher activity individual furthermore effects doped carbon materials degradation activated proposed reaction pathways mineralization explain detailed elsevier rights reserved
many research universities mechanical engineering curriculum include courses teach students essential professional knowledge needed become design engineer professional know regarded academic topic although mechanical designer get job industry need apply knowledge first day topics selecting mechanical elements motors bearings etc selecting proper material coating designed part rarely taught even machine design courses believe mechanical engineering students learn practical skills get basic design experience close gap introduced new design manufacture laboratory senior undergraduate students paper describes laboratory course students activities design projects design projects performed lab follow learned design methodology include design reviews appropriate documentation designed systems produced assembled tested team addition learned technical skills soft skills taught lab related mechanical design include team work self management time management communication skills presentation skills soft skills essential tool every mechanical engineer starts work global changing industrial world authors published elsevier
national maternal mortality rate per live births clear becoming mother carries significant risk order inform scale maternal health services qualitative baseline evaluation explored barriers maternal reproductive health district northern semi structured interviews community focus group discussions four groups six mothers inter related factors including financial means distance health gender roles cultural beliefs patient provider relations influence womens care seeking behavior lack financial means renders cost crucial maternal health services resistance family planning health care compounds challenges women face meeting essential maternal health needs findings suggest user providing facility based delivery free cost improving transportation options fostering trust access health centers significantly improve maternal health district
many conventional computer vision object tracking methods sensitive partial occlusion background partial occlusion little background information exist box tends cause drift end paper propose robust tracker based key patch sparse representation reduce disturbance partial occlusion unavoidable background information specifically first uses patch sparse representations get patch score patch second proposes selection criterion key patch judge patches within box select key patch according location occlusion case third designs corresponding contribution factor sampled patches emphasize contribution selected key patches comparing eight contemporary tracking methods benchmark video data sets experimental results show tracker outperforms classical state art tracking methods presence partial occlusion background illumination change
deficient emotional experience recognized one central features psychopathy impressive body empirical findings regarding emotion processing psychopathy past several decades resulting two broad theoretical perspectives general emotional deficit perspective globally reduced capacity emotional experience processing across emotional spectrum contrast according specific emotional deficit perspective psychopathy associated abnormal experience specific types emotion several distinct hypotheses proposed latter perspective systematically critically review findings peer reviewed research emotion processing psychopathy relation two theoretical perspectives general findings suggest compared controls exhibit behavioral regional brain activation anomalies processing emotion ratings self arousal stimulus valence intensity differ controls however behavioral findings examined separately emotion type overall pattern findings clearly consistent dominant theoretical perspectives emotion processing psychopathy summarize current state field including inconsistencies literature offer alternative explanations findings outline directions future research elsevier ltd rights reserved
lung allocation score system older patients prioritized lung transplantation impact changes health related quality life transplant determined single center prospective cohort study assessed repeatedly years using physical mental health respiratory specific airway questionnaire revised visual analog scale utility measures multivariate linear mixed models jointly modeled death also tested changes valued life activities disability bmi allograft function min walk test exercise capacity predictors change among initial participants eligible improved measures mental health improved greater minimally clinically important difference compared younger participants aged improved less physical mental health improvements disability accounted much improvement era meaningful durable improvements mediated disability identifying factors limiting improvement selected subgroups especially aged needed maximize net benefits prospective longitudinal adult cohort authors find lung transplantation substantially improves health related quality life improvement largely mediated physical disability though older adults undergoing transplantation diagnoses cystic fibrosis derive smaller benefit health related quality life
introduction last years view subclinical endocrine disorders represent forms clinically overt disease emerged accordingly proposed compensated hypogonadism represents genuine clinical subset late onset hypogonadism aim aim present study investigate associations compensated hypogonadism particular clinical psychological characteristics male subjects sexual dysfunction methods excluding documented genetic causes hypogonadism consecutive series patients unit sexual dysfunction studied compensated hypogonadism identified according european male ageing study criteria total testosterone nmol luteinizing hormone main outcome measures several hormonal biochemical instrumental doppler ultrasound parameters studied along results structured interview erectile dysfunction results one hundred seventy subjects compensated hypogonadism whereas overt hypogonadism adjustment confounding factors specific sexual symptoms associated compensated hypogonadism however compensated hypogonadism individuals often reported psychiatric symptoms detected hospital questionnaire score compared overt subjects adjusted odds ratios respectively addition subjects compensated overt hypogonadism increased predicted risk cardiovascular events assessed risk algorithm compared individuals accordingly mortality related major adverse cardiovascular events incidence significantly higher subjects compensated overt hypogonadism compared subjects conclusions present data support concept compensated subclinical hypogonadism represents new clinical entity possibility subclinical hypogonadism normal response hypothalamus pituitary testis axis somatic illness considered studies urgently needed clarify latter point
cultural power public symbol shift time public red followed different paths red rose rapidly fell favor just quickly whereas presence grew steadily time explains different trajectories identify explain differences analysis data use secondary sources create case studies important moments histories symbols paper makes three interventions extends discussion cultural power refining mechanism adding demonstrates importance organizations maintaining high face controversy along politicians introduces violation mechanism symbols cultural power elsevier rights reserved
accuracy imaging bulk volume estimation apple slices process drying temperatures degrees investigated compared physical measurements initial hypothesis estimate bulk volume shaped apple slices diameter thickness imaging imaging diameter showed strong agreement measurements throughout entire drying process however imaging thickness accurate due irregular shrinkage bending phenomena linear model reflecting relationship diameter bulk volume developed validated temperatures degrees showed good correlation imaging diameter bulk volume changes range moisture contents relative percentage error prediction model approximately suggests imaging used robust tool bulk volume estimation apple slices convective drying
service providers often used service strategy customer satisfaction findings current research indicate alone sufficient achieving service excellence specifically work extends prior research suggesting customers positive reactions authentic compared non non genuine two experimental studies examined influence type service provider displays non gender service provider perceptions service quality stereotype content model dimensions competence warmth results suggest type non impacts evaluations service providers terms perceived level competence perceived service quality ratings implications training service providers also discussed elsevier ltd rights reserved
bone remodeling process osteoblasts osteoclasts function maintain modify bone microscopic level bone consists cells create monitor bone matrix cells interact coordinated manner maintain tightly regulated homeostasis regulation responsible observed increase bone gain dominant arm player observed increase bone loss associated osteoporosis manner cells interact bring change bone quality quantity yet fully elucidated efforts understand complexity ultimately lead eradication metabolic bone diseases osteoporosis improved implant longevity experimentally validated mathematical models simulate functional activity offer eventual predictive capabilities offer tremendous potential understanding bone remodeling undertake initial challenge develop mathematical model bone formation validated vitro data obtained bone cells induced quantified days culture cellular automata model constructed simulate vitro characterization permutation tests performed compare distribution mineralization cultures distribution mineralization mathematical models results permutation test show distribution mineralization characterization mathematical model come probability distribution therefore validating cellular automata model elsevier inc rights reserved
eyes shown play key role human social interactions however date comprehensive cross discipline model provided framework account uniquely human responses eye cues review present framework brings together work phylogenetic neural bases perceiving responding eyes specifically argue two process model first process ensures attention information encoded eyes important detection second process permits decoding information contained eyes concerning another persons emotional mental states degree processes unique humans emerge different times infant development mapped onto distinct interconnected brain regions likely serve critical functions facilitating cooperative interactions humans also present evidence show oxytocin key modulator sensitive responding eye cues viewing eyes windows therefore considered hallmark feature human social functioning deeply rooted biology
long acting anti inflammatory drug formulations intra articular injection effective management joint pain inflammation associated sports injuries osteoarthritis study based delivery system evaluated synthesized ester weak base relatively high solubility low much lower solubility physiological degrees biological media including human synovial fluid cleaved mediated situ precipitation observed upon addition concentrated slightly acidic solution phosphate buffer degree accompanying precipitation process pronounced phosphate buffer rotating dialysis cell model slightly acidic solution added donor cell containing resulting continuous appearance acceptor phase initial lag period detectable amounts found rat joint days knee injection acidic solution wiley periodicals inc american pharmacists association sci
present study morphometric analysis three major rainwater harvesting basins province saudi arabia carried using geographical information system gis techniques analysis gis techniques aimed create spatial database three basins used determine morphometric parameters stream attributes morphometric analysis revealed maximum elevation basins upper stream sea level basin respectively maximum elevation decreases steep slopes three basins toward dams site general flow direction streams basin goes southwest northeast following main direction structure basin flow goes south north wide flat areas downstream portion basin near dam site southeast west basin morphometric parameters basin imply basin largest area total stream length basin comes second largest area total stream length basin area total stream length three basins medium drainage density value basins relief ratio basin basin basin noticed ratios indicate high permeable landscape basins medium permeable landscape basin basins similar elongation respectively indicates two basins fairly shape elongation estimated basin respectively drainage pattern basins high dendritic shape basin simple dendritic shape survey performed using vertical electrical analysis reflected presence several different layers resistance high resistance broken vertical bar depth due dry river sediments dams location areas presence climatic change results confirm output geological study give indication state recharge rainwater harvesting three basins
heat storage equipment plays important role micro plants heat released needed pcm heat alternative commonly used storage tanks moreover pcm heat less space amount stored energy paper examines energy performance heating power micro system applied office space hot water thermal energy storage system two latent heat thermal energy storage systems based pcm plate heat compared performances analyzed dynamic conditions operating strategies pcm heat exchanger water tank discussed terms heat demand power supplied internal combustion engine micro system thermal performance two possible paraffin acid form plates inside heat exchanger analyzed processes charging pcm melting pcm charge discharge duration capability deliver appropriate heat transfer rate compared acid provides better results higher heat transfer rates accumulated energy less storage units needed meet heating demand elsevier rights reserved
paper describe findings three year evaluation developed mathematics professional development program commercially available wide scale professional development designed improve teachers mathematical knowledge teaching enable elicit student thinking reasoning mathematics lessons specifically focused helping teachers learn mathematics understand children learn math use assessment develop insight specific students know know develop effective classroom instructional strategies enable student problem solving participants included fourth fifth grade teachers teaching low income schools within single district teachers randomly assigned within schools either business usual control group receive professional development training consisted week long summer institute four six service days school year training run full time trained associates find limited evidence positive impacts teachers mathematical knowledge teaching effects instructional practice student outcomes
background consumption sugar contribute development overweight among children present study aimed evaluate associations family home related factors childrens consumption explored associations within ethnic background child methods cross sectional data population based water campaign study used parents primary school children years completed questionnaire socio demographic characteristics family home related factors childs intake family home related factors study cognitive variables parental attitude subjective norm environmental variables availability parenting practices habitual variables habit strength taste preference regression analyses used evaluate associations family home related factors childs intake results mean age children years girls childs average intake per day childs age parents subjective norm parenting practices parental modelling positively associated childs intake availability home school parental attitude negatively associated childs intake associations study differed according childs ethnic background explained variance full models ranging children turkish ethnic background children dutch ethnic background conclusions results provide support interventions targeting childrens intake identified family home related factors active participation parents also relationships factors childs intake differed children distinct ethnic backgrounds therefore recommend tailor interventions taking account ethnic background family
background observational cohort study commitment food drug administration assess long term safety observational setting focusing predominantly malignancies objective aim study examine potential association cardiovascular cerebrovascular events methods patients years age moderate severe allergic asthma treated baseline followed years analyses included overall events focused subset arterial thromboembolic events comprising death myocardial infarction ischemic stroke transient ischemic attack unstable analysis end point conducted control available potential confounders blinded independent expert panel events results baseline cohorts similar demographic characteristics severe asthma common versus non group treated patients higher rate serious adverse events per person years non treated patients per rates per patients cohort patients non cohort control available confounding factors hazard ratio conclusion observational study demonstrated higher incidence rate events versus non cohort differences asthma severity cohorts likely contributed imbalance increase risk excluded
marker less motion capture seen great progress state art approaches fail reliably track articulated human body motion low number cameras let alone applied outdoor scenes general background paper propose method accurate marker less capture articulated skeleton motion several subjects general scenes even input two cameras new algorithm combines strengths discriminative image based joint detection method model based generative motion tracking algorithm unified pose optimization energy discriminative part based pose detection method implemented using convolutional networks estimates potentials joint kinematic skeleton model potentials serve basis probabilistic extraction pose constraints tracking using weighted sampling pose posterior guided model final energy combine constraints appearance based model image similarity term poses computed efficiently using iterative local optimization since joint detection trained fast since formulation yields combined pose estimation energy analytic derivatives combination enables track full articulated joint angles state art accuracy temporal stability low number cameras method efficient implementation parallel computing hardware gpus test method extensively show advantages related work many indoor outdoor data sets captured data sets made available community research labs availability good evaluation data sets paramount scientific progress many existing test data sets focus controlled indoor settings feature much variety scenes often lack large corpus data ground truth annotation therefore contribute new extensive test data set called mpi indoor outdoor marker less motion capture features scenes varying complexity varying camera count features ground truth reference data different modalities ranging manual joint annotations marker based motion capture results new method tested data data set made available community
microorganisms plant tissues without causing disease help hosts combat pathogens explored hypothesis plant derived foods consumed humans animals host also pathogens food agents laboratory previously cultured library bacterial different members maize corn family including wild relatives screened ability four pathogens escherichia coli clostridium salmonella food agent pseudomonas using dual culture assays two strains found inhibit growth five deleterious strains agar using conserved polymerase chain reaction primers sequencing beneficial found encode genes suggesting potential antibacterial mechanism action production strains confirmed using enzyme linked immunosorbent assay strains originated respectively seeds wild central american maize species wild modern maize latter direct modern maize discuss role played promoting crop suppressing pathogens food agents
techniques employed study elemental constituents traditional medicinal plants generally used many diseases nigeria analyses also carried commonly vegetables medicinal pharmacological importance measurements carried using van accelerator italy whereas measurements carried using van accelerator laboratory results show many medicinal plants contain elements importance human metabolism results vegetables also show presence vital elements needed growth development addition toxic elements include forth detected however contain trace amounts low concentrations calls proper control dose rates samples prevent negative cumulative effects
present study used study test recognition memory task examine brain regions engaged episodic associative memory processes participants evaluated six point rating scale confident whether item presented previous study phase neural activations high low confidence decisions examined old new items two levels item associations items different amounts associations within stimulus set associations defined occurrence statistics medial frontal gyrus posterior cingulate gyrus superior temporal gyrus right hippocampus revealed shaped activation functions greater activations high confidence old new decisions independent associative memory manipulation suggests episodic memory rather processes related confidence account activation brain regions contrast left hippocampus followed different activation pattern modulated amount associations provides evidence role left hippocampus associative memory elsevier rights reserved
paper concerned principle bodies conservative external forces described internal variable theory rice solids influence strain change temperature field ignored unlike principle elastic bodies explicit lagrangian principle bodies generally explicit lagrangian based entropy inequality quasi principle bodies established form inequality explicit lagrangian just lagrangian elastic bodies replacing strain energy free energy quasi principle bodies states actual motion distinguished making action maximum evolution equations internal variables recovered quasi principle
induced disabling motor complication occurring parkinsons disease patients long term treatment although etiology remains unclear accumulating evidence relies excessive dopamine receptor transmission particularly downstream signaling receptors previously reported pharmacological blockade alpha reductase rate limiting enzyme synthesis rescued number behavioral aberrations induced receptor selective non selective agonists without inducing symptoms thus present study designed verify whether inhibitor counteract induced dopaminergic agonists rats first assessed acute chronic effect different doses male rats thereafter fully characterize therapeutic potential impact efficacy assessed abnormal movements use male rats chronically injected days either prior concomitant administration addition investigate whether impact ascribed modulation receptor function assessed primed rats received combination selective direct dopaminergic agonists finally set investigate whether produce similar effect female rats seen males results indicated significantly tested treatment regimens without interfering ability ameliorate use stepping test effect appears due modulation receptor function also reduced abnormal movements induced selective receptor agonist receptor agonist significant also observed female rats although higher tested dose clinical investigations warranted assess whether similar protection seen patients elsevier inc rights reserved
novel variational bayesian mixture experts model robust regression piece wise continuous processes introduced mixture experts model powerful model input space allowing different models operate separate regions however current methods fail safe outliers paper robust mixture experts model proposed consists student mixture models gates student distributed experts trained via bayesian inference student distribution gaussian distribution robust outliers noise non data using simulated data real data obtained bridge robust mixture experts performs better gaussian counterpart outliers present particular provides robustness outliers two forms unbiased parameter regression models robustness complex models
introduction birth control pill pill revolutionized options contraception discussion scientific social science literature media much attention focused issues womens rights including ethics personal choice pill also introduced new questions risk shortly introduction risk thromboembolic disease recognized half century controversies relationship pill thromboembolic disease persisted scientific media communities active discussion debate delivery information risk scientific public attention thromboembolism pill dramatic consequences good bad risk helped change norms regarding right know assess pill linked increased unplanned pregnancy birth abortion rates led change mandated policies regarding new contraceptive products studied brought market paper charts narrative thromboembolic risk pill introduction today reviews corresponding media response history story thromboembolic risk pill explored lens science media contemporary social dynamics frame contemporary understanding risk researchers clinicians individuals public elsevier inc rights reserved
paper examines association great four measures risk maternal child abuse neglect maternal physical aggression maternal psychological aggression physical neglect mothers exposure neglect mothers draws rich longitudinal data fragile families child wellbeing study longitudinal birth cohort study families cities african american hispanic non hispanic white study collected information year follow survey great interview dates linked two measures great national consumer index local rate also included wide range socio demographic controls city fixed effects controls prior parenting results indicate great associated increased risk child abuse decreased risk child neglect households social fathers present particularly adversely affected results also indicate economic uncertainty great measured consumer index rate direct effects risk abuse neglect mediated individual level measures economic poor mental health elsevier ltd rights reserved
ternary copper containing attracted considerable interest since years due high efficiency conversion solar energy promising thermoelectric materials report decomposition study phases using high temperature situ neutron powder diffraction results obtained heating rate min indicate approximate approximate copper rich phase type structure assumed phase associated sulfur results fair agreement recent published data decomposition behavior differs studies terms decomposition temperature thermal stability products reaction finally crystal structure neutron powder diffraction data reported discussed phases high temperature form
data entry result errors cause analytic problems delays research responses lead incorrect statistics statistical conclusions purpose article provide researchers basic strategies avoiding range data entry errors data collection article identifies basic strategies using microsoft inexpensive method data entry used research constrained data files structured range values entered string variables entered researchers inconsistent way code responses data validation accomplished use restricting response options items avoided using count functions number valid responses also discuss advantages disadvantages several methods data entry including using web based data entry relational databases
paper presents equivalent magnetic circuit model predict leakage effect especially end leakage effect surface mounted permanent magnet synchronous machine driven marine current power system end leakage effect usually neglected conventional permanent magnet machines however significant electrical generator due short axial length path analytical expressions end leakage given paper finite element method fem values presented validate proposed analytical model need time consuming fem calculation correction factor base analytical mode proposed adjust results back torque conventional design end leakage ignored calculation calculation results experimental show proposed analytical model accurate analyze leakage effects system
one two dimensional mems scanning resonant quasi stationary beam deflection primarily known devices aperture sizes usually address low power applications high volume markets laser beam scanning gesture recognition systems contrast recently reported vacuum mems feature mirror diameters integrated high dielectric coatings enable mems based scanning applications require large due optical constraints like sensing microscopy high power laser applications like laser displays automotive lighting displays printing general laser material processing work presents modelling control design experimental characterization less mems large aperture size example resonant scanner mirror diameter four integrated lead actuators analyzed finite element method fem model developed computed used calculating mirror extracting high order state space representation mirror dynamics actuation voltages system inputs scanner displacement system output applying model order reduction techniques using matlab compact state space system approximation order computed based reduced order model feedforward control inputs different properly chosen scanner displacement trajectories derived tested using original fem model
extracts important worldwide therapy menopausal symptoms first medicinal product available since germany germany extract review describes developed via clinical studies safety breast breast cancer liver efficacy successful safe medicinal product germany europe world line developing legal frameworks medicinal products germany europe clinical studies observational controlled studies since first placebo controlled study emerged total clinical studies europe america asia published efficacy studies patients received based medicinal product thereof meta analysis nine placebo controlled studies published confirmed reliable efficacy based medicinal products menopausal symptoms
achieving skin longer confined wearing make applying anti ageing reverse visible greater knowledge urban lifestyles encouraging consumers healthy skin times perhaps driving industry align healthcare key categories namely skin care sun care among dynamic segments going forward options anti typically cosmetics
alcohol use among persons living hiv half reported drink alcohol reported heavy drinking alcohol use associated higher risk non adherence antiretroviral treatment art poor treatment outcomes provide guidance clinicians using evidence based approach intervene ensure follow drink alcohol set clinical strategies known screening brief intervention referral treatment fully disseminated help address targets proposed joint united nations programme hiv aids particular receipt sustained art attainment viral suppression copyright association nurses aids care
composite carbon sphere prepared via glucose assisted one synthesis composite consists hierarchical spheres diameter spheres number composite subject lithium converted phase current work activities toward photocatalytic hydrogen evolution reduction dye sensitized solar cells systemically investigated evaluated photocatalyst hydrogen evolution amount evolved hydrogen reach mol times higher synthesized additionally employed counter electrode material based possesses power conversion efficiency higher comparable study demonstrates great potential inexpensive alternative catalysts elsevier rights reserved
although extensively studied functional differentiation containing route towards cerebral cortex fetal development incompletely understood used mice encoding promoter driven red fluorescent protein analyze temporal dynamics expression neuronal identity positioning high resolution developmental additionally developed dual reporter mouse line gfp differentiate containing principal cells prenatal development show upregulated exit proliferative niche remains stably expressed throughout long distance migration towards particularly hippocampus including cohort accumulated boundary embryonic day already reached deep hippocampal layers embryonic day morphologically differentiated birth furthermore entering cortical plate stationary cells hippocampus patch clamp electrophysiology show first signs channel activity embryonic day reliable adult like excitability embryonic day study defines key molecular biophysical properties prenatal brain
rain technically shared social practices mutual agreement individual households study proposes evaluation system rain sharing network considering three performance criteria reliability vulnerability plausible climate change scenarios first study shows system improved terms performance criteria using historical daily rainfall data based storage reliability yield relationship study examined benefits affected climate change years three climate change scenarios three global circulation models used purpose results showed reliability vulnerability improved due sharing improvements become larger climate change conditions contrast reduces slightly due sharing reduction attenuated climate change conditions particular vulnerability reduced significantly climate change results suggest sharing various water resources systems effective climate change adaptation strategy reduces vulnerability increases reliability system
big data solution emerging trend todays world provides enterprises certain advantages however achieving straightforward certain challenges due inherited complexity big data paper aims understand benefits potential challenges big data literature review review results common benefits big data competitive advantage degree customer view prediction power cost effective solution deal amount data customized services customers determining customer value adopting suitable marketing campaign prospects cross products services similarly common challenges associated lack skills analyze data produce valuable insights addressing need speed privacy concerns data data integration diversity findings expected aid researchers practitioners look advantages challenges involved big data initiating project
according definition caused fluctuating wind since fluctuating wind wind speed changing time atmosphere cause vibration structure wind reflects atmospheric boundary layer wind disturbance randomness paper stable type suspension bridge researched problem finite element model bridge set using finite element software response bridge calculated studied influence opposite structures bridge response bridge assessed
objectiveto identify risk factors canine lymphoma dogs new south australia compare factors affecting remission duration owned dogs diagnosed lymphoma presented university veterinary teaching hospital university compared control population dogs seen period time diagnosis lymphoma evaluate association explanatory variables breed age sex outcome case control status resultsthe australian cattle dog odds ratio confidence interval increased odds lymphoma among dogs attending compared results suggested border also increased odds lymphoma among pure breed dogs attending compared dogs conclusionsthe results study confirmed breed lymphoma dogs australian cattle dog increased odds lymphoma
present work addresses development finite element formulation handling bending post analysis composite structures damage inverse hyperbolic shear deformation theory applied finite element formulation effect damage analyzed thin composite plates anisotropic damage formulation used simulate damage based concept stiffness reduction computer programming developed matlab environment excellent agreement results obtained present method references shows technique effective precise parametric studies behavior damaged composite plate presented critical temperatures computed damaged plate using present model thermal post equilibrium paths various parametric variations composite plates mild damage compared results cases validation demonstrated analysis thermal environment composite plates internal present work compared previous works due choice finite element method inverse hyperbolic shear deformation theory analyzing influence damage post behavior plates institution structural engineers published elsevier ltd rights reserved
although millions live among humans worldwide scientific community relatively little cat behavior cognition important perceptual sense many members however role chemical signals cat social relationships fully understood research indicates chemical signals play important role many areas cat behavior including mother offspring interactions exploration environment chemical cues appear play role stress anxiety reduction allowing feel secure environment better understanding cat chemical signals especially relates within species communication lead increase cat wellbeing humans utilize knowledge applied settings therefore purpose review investigate process use chemical signals social contexts identify ways information applied address cat behavioral issues inappropriate box behavior improve cat welfare including species appropriate ways reinforcing human cat bond elsevier rights reserved
one major ideas design multivariate public key generate quadratic forms polynomial map extension field fact scheme multi constructed way variants schemes advantage extension field type reduce numbers variables equations solved decryption process present paper study security whose quadratic forms derived quadratic map extension field propose new attack attack partial information secret affine maps polynomial time field odd characteristic partial information recovered attacker find plain text given cipher text solving system quadratic equations extension field whose numbers variables equations system quadratic equations used decryption process
use first integral method construct closed exact solutions density dependent equation method useful obtaining formal solutions many solutions physically relevant hence carefully determine solutions physically useful problem standard diffusion linear density dependent diffusion obtain physically meaningful exact solutions interestingly case linear density dependence shows strong qualitative agreement standard diffusion case cases wave solutions result initial concentration either tends finite positive value large time one obtain wave solutions general wave speeds standard diffusion case density dependence diffusion resulting wave speeds take specific values depending values model parameters stronger density dependent diffusion involving quadratic higher order functions concentration show equation integrable exact solutions expected cases
present quantum key distribution method allows demonstrate practical quantum cryptography used obtaining cryptographic key encode information communicated legitimate parties generally relates key sharing method system receivers particularly system method receivers aspect method system capable forming first signals different phases polarization second signals different delay time transmitter two signals share key receiver first signal generated different phases polarization protect transmission channel reference time second signal state first signal delay time first signal second signal key method leads increase length shared key method used implement practical system used switching protocol protocol optical fiber one way system free space security secure keys generated network managed key management layer key management agents used data send receivers proposed schemes aimed provide secure end end communication
study novel second order universal filter using current feedback amplifier commercially available active component presented signal flow graph method used synthesize filter proposed filter three high impedance input one output multiple input single output configuration generate filtering functions namely low pass band pass high pass band reject pass output terminal selecting different input signal combinations validity proposed circuits demonstrated simulations elsevier gmbh rights reserved
objectives changes estrogen receptor expression likely underlie differential metabolic effects estrogen pre postmenopausal women aim current study determine whether gene expression abdominal femoral subcutaneous adipose tissue associated age menopause regional adiposity methods studied pre post menopausal respectively age normal weight mean bmi women similar total fat mass abdominal femoral alpha beta mrna expression determined qpcr results total fat mass differ pre postmenopausal women compared premenopausal women ratio lower postmenopausal abdominal femoral inversely associated age abdominal respectively femoral respectively related age menopause inverse association age persisted adjusting trunk fat mass estradiol leptin conclusion among healthy pre postmenopausal women increased age associated decreased balance era beta abdominal femoral subcutaneous adipose tissue elsevier inc rights reserved
recent advances cognitive impairments among difficult treat symptoms neuropsychiatric disorders deficits information processing contributing memory impairments found across neuropsychiatric related disorders previously shown mutations gene encoding binding protein lead abnormalities synaptic glutamate release prefrontal cortex pfc hippocampus cognitive deficits glutamatergic transmission important cortical recurrent excitation allows information processing pfc investigate possible means restoring glutamate release improving cognitive impairments assess effects increasing endogenous levels brain derived neurotrophic factor bdnf deficient mouse model increasing endogenous levels bdnf aid cognitive deficits given roles bdnf synaptic transmission plasticity increase bdnf use novel strategy repeated intraperitoneal injections recently shown therapeutic value several neurology related disorders wild type mutant genotypes tested recognition memory followed measuring endogenous bdnf levels within pfc genotypes treated week either saline relative mice mice demonstrated impairments recognition memory lower calcium treatment mice exhibited significant improvements recognition memory increases calcium endogenous concentrations bdnf results show promise cognitive impairments seen neuropsychiatric disorders light role wiley periodicals inc
paper presents novel concept virtual frame enhancing dynamic performance machine tool flexible structural frame dynamic properties machine directly affected stiffness frame reference system thus frame superior dynamic capabilities achieved developed concept require physical components associated frame hence ideal machine tools requirements small footprint ultra precision performance concept relies accelerometer based dynamic displacement feedback technique accelerometer used precision frame displacement sensor concept require complex controller realized shelf controller concept demonstrated linear motion system simplified version compact size machine servo bandwidth dynamic stiffness improved respectively key parameters improving machining accuracy authors published elsevier inc
used treat skin diseases including eczema dermatitis south korean medicine present study investigated curative effects extract induced atopic dermatitis like skin lesions balb mouse model briefly dorsal skin balb mice sensitized three times whereas challenged twice repeated treatment induced like lesions effects like lesions evaluated clinical observation histopathological analysis immunohistochemistry enzyme linked immunosorbent assay addition reverse transcription polymerase chain reaction western blotting performed treatment reduced like lesions determined clinical observation histopathological analysis detection serum levels histamine immunoglobulin cytokines regards mechanism action inhibited phosphorylation yes related novel tyrosine kinase spleen tyrosine kinase mitogen activated protein kinases kinase akt essential roles production various cytokines lymph nodes suppressive activity due inhibition series events including release proinflammatory cytokines results present study strongly suggest exerts anti effect inhibiting akt pathways therefore considered effective herbal remedy treatment
objective review findings clinical relevance add knowledge antisocial aggressive behaviour among persons schizophrenia method literature review results recent evidence shows individuals develop schizophrenia present cognitive deficits psychotic like experiences internalizing externalizing problems childhood many relatives present schizophrenia related disorders also antisocial behaviour increased risk aggressive behaviour among persons schizophrenia robustly established recent findings show first contact clinical services psychosis people schizophrenia engage aggressive behaviour identified first episode distinct types present history antisocial aggressive behaviour since childhood began engaging aggressive behaviour illness antipsychotic medications treatments shown effective schizophrenia needed types patients additionally history antisocial aggressive behaviour since childhood require cognitive behavioural programs aimed reducing behaviours promoting prosocial behaviour reducing physical cannabis use likely reduce aggressive behaviour evidence suggests threats others often precede conclusions first contact services patients schizophrenia engaged aggressive behaviour identified treated schizophrenia aggression research needed identify interactions genotypes environmental factors conception promote protect development aggressive behaviour among persons schizophrenia
prior research supported mere presence hypothesis suggests cell phones act environmental negatively impact quality face face interactions study conducted experiment determine whether cell phone presence negatively influences conversation satisfaction specifically network member dyads engaged unstructured conversations one partners cell phone either absent present results revealed whereas mere presence cell phone influence conversation satisfaction individuals whether cell phone present significantly negatively impact pre posttest reports conversation satisfaction implications findings research mere presence hypothesis directions future research discussed
horizontal gene transfer occur related bacteria thus leading genetic plasticity cases acquisition novel resistance traits species responsible human infections express various acquired beta resistance genes including different classes genes report clinical isolate strain displaying resistance including together reduced susceptibility susceptibility expanded spectrum using biochemical tests significant hydrolysis detected since pcr failed detect acquired genes commonly found used whole genome sequencing approach revealed presence class gene far identified species gene located element like gene remarkably two genes putative binding sites inserted site located like small large subunit genes increased expression two genes resulted time tandem amplification element revealed southern blotting first isolation clinical strain producing class first description dependent insertion antibiotic resistance genes within study revealed new role biology
neural basal ganglia especially beta frequency band hallmark parkinsons disease considered contrast healthy basal ganglia show low levels currently unknown oscillations arise brain transmitted basal ganglia makes dependent dopamine external part recently identified hub nucleus basal ganglia possessing intrinsic inhibitory connections possibly also gap junctions study show conductance based network model basal ganglia combination sparse high conductance inhibitory synapses sparse low conductance gap junctions external part effectively whole network however gap junction coupling became strong enough effect activity synchronized particular sustained periods beta coherence occurred neuron pairs gap junctions change conductance dopamine level suggest gap junction coupling mechanism contributing development beta basal ganglia
way data structures organize data often function sequence past operations organization data referred data structures state sequence past operations constitutes data structures history data structure state therefore used oracle derive information history history sensitive applications privacy voting imperative historical information contained within data structure states data structure history hidden making data structures history independent paper explore achieve history independence observe current notions significantly limited number scope two existing notions weak strong protect canonical representations resulting need broad encompassing notion capture broad spectrum new notions end introduce delta generic game based framework enough accommodate existing new notions essential step toward delta explore concepts abstract data types data structures machine models memory representations finally bridge gap theory practice outline general building end end history independent systems demonstrate use designing two history independent file systems
observing system climate six satellite radio mission launched april close proximity satellites months launch provides unique opportunity evaluate precision global positioning system gps radio electron density nearly simultaneous observations data consecutive days july august divided ten groups terms daytime latitude cases best precision values found peak height slightly degrade daytime groups seen electron density profiles height exhibit substantial improvement precision groups rather diverse particular precision becomes better different levels height overall results show depending group uncertainty associated precision order measured electron density values even worse retrieved values tend sometimes negative although rely directly electron density values shape profiles indicative features waves sporadic layers profiles precision qualitatively quite independent daytime latitude nearly pairs studied exhibited difference line sight angles peak height larger degrees analyzing find clear indications significant error electron density profiles due spherical assumption height differences precision setting rising gps attributed modification processing algorithms applied rising cases initial period mission published elsevier ltd rights reserved
background increasing recognition primarily tubular interstitial chronic kidney disease ckd clustering agricultural communities low middle income countries although currently unclear whether unified underlying aetiology conditions collectively termed ckd cause estimated led premature deaths tens hundreds thousands young men women last decades thus urgent need understand aetiology pathophysiology condition international comparisons provided first steps understanding many chronic diseases comparisons rely availability standardised tools estimate disease prevalence particular problem ckd since disease asymptomatic late stages biases inherent methods used estimate glomerular filtration rate population studies highly variable across populations method therefore propose simple standardised protocol estimate distribution populations disadvantaged populations egfr epidemiology degree study involves quantification renal function representative adult population based sample requirement serum creatinine measurements along storage samples future measurements estimates body composition order obtain valid comparisons estimated egfr within populations discussion methodology present potentially applicable anywhere particular focus disadvantaged populations since appear susceptible although protocol also used specific groups occupational groups thought excess risk primary aim degree project characterise population distribution egfr multiple regions international comparisons performed standardised approach possible estimate scale variation impaired kidney function affected areas data provide insights important social demographic environmental risk factors increasingly recognised disease
previous studies investigating person perception synchronized movements found enhance memory person attributes although effect robust including process actuated less understood study two hypotheses investigated enhanced memory person attributes result increased gaze time greater attentional focus explore possible mechanisms context observing eye tracking study conducted subjects watched videos pairs positioned one synchronized music asynchronous results consistent first hypothesis music gives rise increased visual inspection times addition preference upper body lower body across synchronous asynchronous conditions subsequent single eye tracking study investigated across different body regions including head legs significantly greater times recorded head legs attracted significantly less time body region lastly study sought identify gestures responsible head directed specifically asked whether features specially designed direct observers gaze towards face main communicative portal respect transmission intent affect empathy
pacific small island developing states among vulnerable impacts climate change besides dependent imported petroleum products world use renewable energy help minimize economic risk associated price volatility fossil fuels region increasingly adopting renewable energy targets policies successful examples deployment pacific exist however many barriers persist prevent use regions resources larger scale challenges deployment islands grouped six categories lack data need policy regulatory frameworks iii scarcity financial opportunities lack human resources costly infrastructure socio cultural based survey conducted among main stakeholders region within framework pacific region capacity building initiative international renewable energy agency carried cooperation pacific community paper identifies specific characteristics challenges context pacific provide qualitative assessment identifies recommendations overcome challenges elsevier ltd rights reserved
article deals removal cobalt ions using zinc oxide prepared via gel method supercritical drying characterised via xrd sem ftir bet surface area techniques kinetics equilibrium thermodynamic studies metal ions adsorption conducted batch mode experiments varying parameters contact time initial ion concentrations nanoparticles dose temperature data revealed significant dependence adsorption process concentration temperature found enhance adsorption rate indicating nature adsorption adsorption pseudo kinetics model adsorption process found match langmuir adsorption isotherm zno nanoparticles successfully remove center dot ions elevated temperature metal ions adsorption described spontaneous process mechanism metal ions adsorption proposed
mining waste generated mining mineral raw materials utilization mining wastes many organizations dealing mining industry important reduce negative impacts environment less landscape take less place landfill waste recovery economic benefit organization least also law article discusses use mining waste czech republic method compared possibilities use waste poland concerning mining waste wastes become secondary materials construction meet requirements construction materials engineering country different requirements materials engineering therefore necessary deal legal aspects use mining waste
prospect consistent computer aided refinement enzymes explored simulating hydrolysis substituted ester wild type mutant candida lipase using several strategies particular focused use empirical valence bond method quantitative screening evaluate found extensive sampling essential obtaining converging results requirement points towards possible problems approaches use limited conformational sampling however performing proper sampling appears give encouraging results offer powerful tool computer aided design enzymes also explore faster strategies identifying mutations help directed evolution experiments approaches require refinement
stem cell technologies especially patient specific induced stem cell directed differentiation hold great promise changing landscape medical therapies proper exploitation methods lead personalized organ organs necessary develop methods differentiated cells functional organ level tissues generation three dimensional human tissue models also holds potential medical advances disease modeling full organ functionality necessary disease pathophysiology specifically true lung diseases animal models often human disease present method generation self assembled human lung tissue potential disease modeling drug discovery lung diseases characterized progressive irreversible idiopathic pulmonary fibrosis ipf tissue formation occurs overlapping processes cellular adhesion multiple alveolar templates rotation cellular contraction addition transforming growth factor beta single cell type mesenchymal resulted typical seen ipf two dimensional ipf fibroblast cultures furthermore lung modified contain multiple lung cell types assembled correct anatomical location thereby allowing cell cell contact lung microenvironment bottom approach synthesizing patient specific lung tissue scalable system allows development relevant human lung disease models potential high throughput drug screening identify targeted therapies
primary hypothyroidism usually leads retardation linear growth delay even arrest puberty juvenile patients rare cases pediatric patients hypothyroidism present signs syndrome includes juvenile hypothyroidism delayed bone age puberty present study reported rare case complications including obesity short pituitary hyperplasia addition comprehensive literature review performed illustrate treatment outcome pediatric patients present study contributed current knowledge regarding diagnosis treatment pediatric patients
adult victims child physical abuse likely intimate partner violence ipv however victims become violent toward partners suggesting factors moderate risk ipv drawing background situational model study examines independent interactive effects history negative affect arising conflict intimate partner predicting physical ipv fifty three heterosexual dating couples completed questionnaires assessing history physical ipv couples discussed largest source conflict relationship min videos discussions coded negative affect using actor partner interdependence model approach account dyadic interdependence data findings revealed average levels negative affect severity predicted greater ipv men women however average levels negative affect conflict positively predictive ipv men findings revealed interaction men positive association severity ipv became stronger negative affect conflict increased
polyphenol potential health effects absorbed humans measurement plasma used biomarker intake however chemical nature blood still known although one possibility found unchanged form original food propose existence plasma unlikely since metabolic beta capacity small intestine liver great escape critically examine limited number studies detect blood current evidence absorption compounds gastrointestinal tract need comprehensive identification circulating compounds since polyphenol expected metabolites plasma almost identical chromatographic properties acid studies nature metabolites plasma urgently needed proposed biological activities assessed suitable biomarker exposure established
western societies youth consider middle age onset deterioration prevalent discourses middle aged women focus primarily negative developments lives increased health risks menopause little known however lived experiences age group article share information health ageing related attitudes women aged years took part physical activity intervention denmark drawing concepts disciplinary power explored via semi structured interviews womens reasons participation experiences playing team game interviews revealed internalized messages healthy ageing felt previous inactive lifestyle however participation also influenced changing life circumstances now time exercise contrary previous experiences found playing games provided
investigated adsorption thermodynamics adsorption kinetics salt onto adsorption isotherm studied using langmuir models separation factor indicates nature adsorption process favorable adsorption physical indicated high adsorption intensity small mean free energy mol negative mol indicates spontaneous nature adsorption negative mol confirms nature adsorption process whereas negative mol suggests configuration surface less random pseudo second order kinetic model fits experiment data based characteristics adsorption thermodynamic adsorption kinetics potential seawater process published elsevier
adenine nad biosynthetic pathway mediated key nad biosynthetic enzyme plays pivotal role controlling many biological processes metabolism circadian rhythm inflammation aging past decade mediated nad biosynthesis together key downstream mediator namely nad dependent protein demonstrated regulate glucose lipid metabolism tissue dependent manner discoveries provided novel mechanistic therapeutic insights obesity metabolic complications insulin resistance important risk factor developing type diabetes cardiovascular disease review focus importance adipose tissue mediated nad biosynthesis pathophysiology obesity insulin resistance also critically explore translational clinical aspects adipose tissue nad biology
children spend majority classrooms often low indoor air quality limited financial resources initial running costs mechanical ventilation systems designing effective natural ventilation systems schools difficult due intense use classroom spaces dependence building geometry outdoor conditions building thermal airflow simulation tools fundamental predict system performance design phase predictions tools validated data real buildings paper presents set detailed measurements driven natural systems three classrooms located two buildings portugal rooms located two educational buildings university different driven natural systems without experimental measurements used validate three node model implemented open source thermal building simulation software validation results show building thermal simulation model tested able predict bulk airflow rate average error addition good agreement also obtained vertical temperature prediction average error corresponding average deviation degrees analysis rooms results revealed expected increasing height significant positive impact system performance performance natural systems depends number thermal room heat load increasing number lowers average occupied zone air temperature increases bulk airflow rate light complexity cases tested uncontrolled boundary conditions results comparisons performed measurements simulations contribute increase confidence use simulate driven natural systems elsevier rights reserved
background allergy immunotherapy result systemic allergic reactions even life threatening anaphylaxis requiring administration objective objective study describe use clinical trial development programs rapidly immunotherapy tablets inc denmark pharmaceutical ltd japan methods data use collected grass tablet trials allergen units dose placebo short tablet trials placebo house dust mite tablet trials placebo results grass tablet trials used times grass tablet placebo eight grass tablet related adverse events aes systemic allergic reactions local mouth swelling tablet trials used times subjects tablet placebo anaphylaxis four tablet related aes systemic allergic reaction local mouth swelling tablet trials administered times tablet placebo four related aes systemic allergic reaction local events events related tablet treatment occurred within first week treatment day subject self administered conclusions response tablet related reactions clinical trials uncommon typically occur within first week treatment rarely self administered tablet related events treated american academy allergy asthma immunology
authors article respond call answer challenge past related question course great war numerous investigations history war authors show essence third plans respect union general particular using logic alternative history analyze first possible actions military political leadership germany situation similar blockade second possible military consequences loss city river point view military science considerations proved actions command right also alternative existed
cytomegalovirus infection occurs frequently young children infected major source transmission oral shedding infants primary infection comprehensively characterized using quantitative polymerase chain reaction weekly months three phases oral shedding identified expansion transition clearance viral expansion occurred median weeks median time days transition phase expansion median weeks peak viral load reached clearance slow day median half life shedding resolve observation infant mathematical modeling demonstrated prolonged oral expansion explained low within host reproduction number median delayed immune response decreases infected cell half life thus prolonged oral shedding observed primary infection explained slow viral expansion inefficient immunologic control
study analyzed real working parameters cycle internal combustion engine using fuel hydrogen plus gasoline two equations determined first equation reagents air second equation added quantity obtained hydrogen cell two sets equations consumption power determined chemical equations working conditions altitude kpa atmospheric pressure temperature single cylinder engine powered hydrogen plus gasoline used getting real data engine power using mixtures air gasoline hydrogen theoretical power without increased real power without increased theoretical fuel consumption kwh addition less kwh actual consumption indicates manufacturer kwh
objective non alcoholic fatty liver disease claimed liver phenotype metabolic syndrome turn associated male hypogonadism assessed whether independent association androgen deficiency revealed men chronic spinal cord injury sci exhibit high prevalence biochemical androgen deficiency combination risk factors metabolic syndrome design fifty five consecutive men chronic sci admitted rehabilitation program underwent clinical biochemical evaluations liver ultrasonography results diagnosed patients men older exhibited significantly higher body mass index homeostatic model assessment insulin resistance triglycerides values lower total free testosterone levels engaged significantly poorer weekly leisure time physical activity multiple logistic regression analysis total free testosterone levels exhibited significant independent association risk increased indeed total testosterone free testosterone adjustment confounders men total testosterone adjustment confounders conclusion evidence independent association low testosterone strongly reinforced demonstration men chronic sci spite many confounders peculiar population
increasing interest lean thinking traditional manufacturing engineering organizations recently non traditional white settings despite potential benefits organizations implemented lean facing problems sustainability study examine lean thinking role helping sustainability lean paper reports recent initiatives leading changes ownership intellectual capital surrounding lean thinking new core expertise issue expertise lie study based interviews senior managers responsible lean management activity strategy within large organizations traditional non traditional white organizations analyses expert opinions identify implicit strategies around lean implementation generate insights spectrum people related issues needed success lean adjustments needed architecture terms three core elements skills competencies needs implications practices essential role behaviours intended create amongst employees also examines expertise intellectual capital lie identifies structural solutions pursued
gastrointestinal stromal tumors mesenchymal tumors distinguished driver mutations kit cases mutations linked response inhibitor independent prognostic impact describe prospective study molecular characteristics french adult patients analyzed routinely national hospital program molecular cancer diagnosis patients diagnosed university hospital august october prospectively included present study kit codon mutations analyzed sanger sequencing kit mutations detected cases respectively total different mutations detected never described expected kit exon exon mutations associated small bowel gastric respectively mutation found molecular studies critical improve management study enhances current knowledge describing new mutations kit common molecular pattern kit exon substitutions also described first time study significance remains unknown since genetic environmental risk factors favoring development dna repair defects exposure currently known
objectiveto evaluate efficacy safety optimum dose daily patch overactive bladder methodsa randomized double blind trial conducted patients overactive bladder symptoms received patch placebo daily primary endpoint change daily frequency baseline end study resultsa total patients randomized placebo group patch group patch group frequency deviation decreased placebo group group group compared placebo group decreased significantly groups test respectively decrease similar groups groups showed significant improvement urgency urge incontinence incontinence nocturia mean volume five six domains health questionnaire dry mouth noted group group constipation comparable groups placebo group application site reactions less frequent group group conclusion efficacy patch confirmed optimum dose japanese patients overactive bladder
hybrid powertrain provides driving torque based upon vehicle acceleration position due slow response internal combustion engine electric motor often provide additional torque transient vehicle operations cold start operations available battery power significantly reduced due cold temperatures due starting delay engine battery provide power level beyond normal operation limit electrical motor meet torque demand dramatically shorten battery life however desired powertrain torque predicted engine started early predicted future powertrain power higher battery normal operational range hence duration battery operated normal operational range significantly reduced leading extended battery life makes predicting future torque demand based upon current past torque demand data important subject many existing studies research studies focused subject paper proposes adaptive recursive prediction algorithm estimate future desired powertrain torque compares performance proposed algorithm two existing prediction algorithms step step fixed gain algorithms three prediction algorithms studied federal test procedure another four typical driving cycles simulation results show adaptive recursive prediction algorithm reduces prediction error significantly maximum prediction error addition reduced computational load makes feasible real time implementation introduced weighting factors past current data key improve prediction accuracy avoid prediction calculation addition due online update regression gain proposed algorithm also robust driving behavior variations
introduction endocrine pancreas plays pivotal role glucose metabolism regards morphogenesis conflicting data regarding timing appearance cells proportion arrangement cells within present work baseline study conducted indian studied also observed expression anti insulin antibody different gestational ages methods ten fetal specimens pancreas gestational ages weeks department obstetrics hospital new fetuses fixed serial sections stained eosin sections processed specific marker cell anti insulin antibody results cells arise epithelium cells contain insulin week seen immunostaining small seen weeks arrangement cells different variable formation continues throughout fetal life discussion study endocrine pancreas begins differentiate early fetal life growth maturation associated coordinated vascular development week intrauterine life fetal pancreas sufficient morphological maturity fulfil hormonal requirements growing fetus copyright anatomical society india published elsevier india ltd rights reserved
concept functional neutrophil subsets new clinical significance malignancies unknown study investigated role high high high high neutrophil subsets head neck squamous cell carcinoma patients neutrophil subsets play different roles immune related activity cancer based profile activation state migration ability within tumor site important predicting cancer tumor biopsies blood obtained newly diagnosed untreated patients healthy controls neutrophil subsets phenotype characterized using flow cytometry isolated assessed anti tumor immune functions compared controls patients exhibited increased high neutrophils blood subset displayed distinct phenotypes high expression subset prone migrate tumor facilitated tumor derived furthermore also found activate neutrophils thereby promoting subset transition various assays demonstrated activated high neutrophils inhibited migration proliferation induced apoptosis cancer cells neutrophil detected activated high neutrophils tumor biopsies suggested high neutrophils anti activity via neutrophil extracellular furthermore increased fraction high neutrophils shown correlate increased survival rate study demonstrates clinical relevance high neutrophil subset providing evidence increased migration capacity anti tumor activity including increased net formation finally correlation increased survival patients new evidence growing distinct neutrophil subsets diverse roles cancer immunology clinical link remains established study demonstrates clinical relevance high neutrophil subset head neck squamous cell carcinoma patients increased fraction anti high neutrophils circulation compared healthy controls subset enhanced capacity elicit neutrophil extracellular nets increased fraction high neutrophils circulation correlated increased survival findings demonstrate anti role high neutrophil subset
new fast computational structure identical forward backward modified discrete cosine sine transform computation described result systematic construction fast algorithm efficient implementation complete time domain cancellation analysis synthesis filter banks shown computational structure used thus significantly reducing design time resources corresponding generalized signal flow graph regular defines new sparse matrix discrete cosine transform type matrices identical fast computational structure provides efficient implementation layer iii audio coding labs steps derive computational structure described detail put perspective comprehensive list references classified categories provided covering new research results achieved time period theoretical practical developments analysis synthesis filter banks general mathematical symmetry special properties fast algorithms efficient software hardware implementations crown copyright published elsevier rights reserved
segmentation based image analysis techniques routinely employed quantitative analysis complex microstructures containing two phases primary advantage approaches spatial information distribution phases retained enabling subjective quality segmentation subsequent analysis process computing data morphologically complex microstructures gathered error prone detectors challenging special care taken artifacts segmentation make subsequent analysis conclusions uncertain paper demonstrate using two phase nickel base microstructure model system new methodology analysis shapes using segmentation free approach based histogram oriented gradients feature descriptor classic tool image analysis benefits methodology analysis microstructure two three dimensions demonstrated
paper novel structure compact slot antenna design optimization procedure presented order achieve sufficient number degrees freedom necessary obtain considerable size reduction rate slot parameterized using spline curves antenna dimensions simultaneously adjusted using numerical optimization procedures fundamental bottleneck high cost electromagnetic simulation model structure includes reliability sma another problem large number geometry parameters nineteen computational efficiency optimization process therefore performed using variable fidelity simulations surrogate assisted algorithms optimization process oriented towards explicit reduction antenna size leads compact footprint acceptable matching within entire band simulation results validated using physical measurements fabricated antenna prototype
study rabbits days old randomly divided four groups rabbits studied throughout day experimentation period order determine impact dietary supplementation composed dry ground leaves commercial mixture containing main ingredient performance health meat quality basal diet given control group significant differences found performance rabbits group selected evaluation regarding apparent rabbits fed control diet diet low level higher level animals supplemented high levels respectively ether extract lower treatment group addition compared control group respectively process performed day old rabbits study characteristics meat quality blood parameters contents gut histology total leukocyte counts control animals lower rabbits fed respectively fermentation contents rabbits fed showed higher concentrations total volatile fatty acid dry matter acetic acid lower ammonia levels compared control group pcr gradient gel electrophoresis analyses performed evaluate microbial community hard collected days whereas contents taken results demonstrated treatment groups similarity microbial communities higher compared control group moreover age shown influence microbiota diversity conclusion results study indicated supplementation rabbit diets leads increase total white blood cells total acetic acid concentration decrease ammonia levels high level supplemented without causing adverse effects parameters
objectives objectives study describe compare treatment persistence first second line subcutaneous tumor necrosis factor alpha inhibitors patients ankylosing spondylitis psoriatic arthritis psa rheumatoid arthritis collectively immune mediated rheumatic disease sweden estimate contrast health care costs two groups methods patients initiated first second december identified prescribed drug register persistence estimated using survival analysis costs comprised specialized outpatient care inpatient care medication persistence analysis stratified immune mediated rheumatic disease diagnosis results total patients treated first patients treated second identified baseline characteristics differed two groups therefore propensity score matching analysis implemented second line patients matched first line patients four cohort pairs psa diagnoses combined generated patients treated first statistically significant higher persistence patients treated second psa diagnoses combined patients treated second incurred higher costs patients treated first conclusion overall persistence first higher persistence second furthermore second associated higher costs first therefore prescribing best long term persistence first beneficial
concept transformation molecules materials established field chemical vapor deposition cvd atomic layer deposition however materials scientists always new materials enhanced functionalities eventual application devices new materials become integral part modern day technology especially field importance cvd processes high throughput coating complex device geometries recognized applications since underlying precursor chemistry one main parameters processes still scope exploratory research terms precursor design development demands advanced technologies wide range precursors used realize specific class materials trend recently driven reduced thermal budget needed especially components employed developments precursors cvd point designer precursors set play major role field materials engineering desirable growth conditions achieved proper selection compounds stem available class metal complexes even engineered compounds review article concept utilizing old new cvd applications highlighted representative functional materials namely group rare earth oxides recent results precursor development carried inorganic materials chemistry research group germany summarized published elsevier
ability measure velocity aquatic environment fundamental challenge engineers sport scientists past video systems first choice monitor athletes training acceptance small inertial sensors new ways investigating athletes movements small systems light easy use hinder athlete training allowing easy tracking training improvements research used self developed low cost inertial sensor system attached lower back record acceleration performing sub surface wall push offs recorded data downloaded matlab data analysis using seven wall push velocity three different efforts analysed compared cable velocity meter criterion measure using regression analysis maximum velocity determined accelerometer unit linearly related benchmark criteria biomechanical technique determination maximum velocity acceleration data verified authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering university
system developed fulfill entire coupled analysis cycle design analysis complex fusion reactor components provides advanced modeling capability converting computer aided design geometries monte carlo geometries employing constructive solid geometries unstructured meshes also realizes generic coupling computational fluid dynamics finite element thermal structural analyses system seamless extensible generic system intensively verified fusion applications
climate change extreme heat events increasing important understand vulnerable heat associated morbidity determined association hospitalizations natural causes cardiovascular respiratory renal diseases diabetes mellitus acute myocardial infarction usa different intensities durations assessed confounding individual characteristics health insurance proxy income modified associations obtained inpatient database national climatic data center environmental protection agency data september three counties employed case crossover design modeled indicator temperature percentile thresholds days examined effect modification patient age race sex health insurance pooled county results among non whites pooled odds ratio hospitalization percentile threshold non days renal diseases increased increasing intensity null among whites observed null association cardiovascular hospitalization percentile threshold associated myocardial infarction hospitalizations confounding minimal associated hospitalizations renal disease among non whites information vulnerability heat associated morbidity helps characterize public health burden target interventions including patient education
paper focuses dynamic behavior magnetorheological fluid undergoing unsteady oscillatory shear presence applied magnetic field problem studied nonlinear mechanical system perspective using tools analysis phase space frequency response neural networks parameters identification purpose several numerical simulations performed compute motion magnetic rigid spheres newtonian carrier liquid particles interact throughout process dynamic simulation apply external magnetic field together oscillatory shear two deterministic mechanisms compete align particles preferential direction nonlinearities introduced system due particle particle interaction intensity non deterministic mechanisms regulated two physical parameters appear present formulation numerical simulations based sophisticated technique compute convergent hydrodynamic magnetic interactions numerical research code developed authors used purpose code accurate computationally efficient present work intends show several tools otherwise thought mostly applied dynamics nonlinear systems used explore physical behavior wet suspensions fluid mechanics moreover several details complex materials captured physically interpreted use proposed tools elsevier rights reserved
objective evaluate effect introduction treatment sterilization guidelines number injections methods randomly selected health units region visited factors determined contribute hiv transmission injections workshop senior health workers region findings presented treatment sterilization guidelines developed thereafter held health centre region four months intervention data collected health facilities order assess changes prescribing practices sterilization procedures results knowledge indications injections improved markedly staff proportion outpatients receiving injection dropped proportion patients receiving injection dropped procedures sterilization keeping equipment administration injections improved smaller proportion tended contaminated reduction significant conclusion considerable improvement knowledge prescription practices procedures observed level carrying training programme
intestinal syndrome congenital visceral characterized severe dilation urinary bladder defective intestinal motility genetic basis ascribed spontaneous autosomal dominant mutations actin gamma smooth muscle contractile gene however evidence suggesting recessive origin disease also exists using combined mapping whole exome sequencing genetically isolated family found carry premature termination codon gene preferentially expressed vascular visceral smooth muscle cells parents heterozygous mutation exhibited abnormalities child homozygous premature termination codon displayed symptoms consistent used associated protein genome editing generate similar premature termination codon mice homozygous mutation showed loss protein pathology consistent including late gestation expansion bladder rapid loss resulted reduction actin cytoskeletal dense bodies impaired intestinal smooth muscle results define disease gene suggest role establishing normal smooth muscle cytoskeletal contractile coupling
background clostridium rate symptomatic patients represents infection colonization predict extent compared asymptomatic colonization rate symptomatic positivity rate hospitalized patients using nucleic acid testing methods july april formed stool samples collected asymptomatic patients admission hospital hospital stool samples symptomatic patients suspected collected testing per provider order polymerase chain reaction pcr assay usa performed stool samples pcr cycle threshold used measure genomic equivalents chart review performed obtain clinical history medication exposure results found asymptomatic rate confidence interval positivity rate symptomatic patients median pcr cycle thresholds significantly different asymptomatic carriers symptomatic positives versus among asymptomatic patients carriers subsequently became symptomatic within hospitalization single multivariate analysis identify demographic clinical factors significantly associated conclusions asymptomatic rate similar symptomatic positivity rate suggests majority pcr positive results symptomatic patients likely due colonization disease specific biomarkers needed accurately diagnose patients disease elsevier inc rights reserved
high resolution reconstruction technology developed help enhance spatial resolution observational images ground based solar near real time reconstruction performance achieved high performance cluster using message passing interface mpi however much time spent solar reconstruction design implement novel parallel method reconstruction solar shared memory machine using real tests performed verify correctness codes present details several parallel reconstruction steps parallel implementation various modules shows great speed increase compared single thread serial implementation speedup achieved one reconstruction timing result one pixels shows clear advantage greater number threads novel parallel method valuable real time reconstruction solar images especially high performance cluster
purpose study study determined whether self reports unmet need help activities daily living disabilities prognostic emergency department utilization design methods prospective cohort study community living disabled subjects combined national long term care survey responses linked medicare data negative binomial count model computed assess association unmet need number subsequent admissions statistically adjusting predisposing enabling need characteristics associated admissions among older adults results adjusted annual incidence rate admissions higher unmet versus met need confidence interval admissions falls injuries higher unmet versus met need toward significance admissions skin breakdown significant admissions dehydration implications unmet need prognostic admissions especially falls injuries future research needed determine whether resolution unmet need reduces utilization
purpose study investigate whether individuals general population high scores autism spectrum quotient constituted single homogeneous group cohort university students investigated cluster analysis based original five subscales autism spectrum quotient based results analysis students divided six clusters first low scores five subscales second high scores attention detail subscale third fourth intermediate scores subscales fifth high scores four five subscales low scores attention detail subscale sixth high scores five subscales students high total autism spectrum quotient scores divided two groups one high scores four subscales low scores attention detail subscale high scores five subscales results study suggested individuals general population high autism spectrum quotient scores consist two qualitatively different groups
paper shows performance curves obtained experimental campaign following different prime internal combustion engine based hybrid system absorption size related engine actual electrical power values hybrid system size electrical virtual power rig used plant value cooling thermal power experimental results obtained smart facility installed innovative energy systems laboratory power group university facility designed perform tests smart grids equipped different generation technologies develop improve innovative control optimization tools performance curves obtained two different approaches tests real prime engine measurements rig hybrid system second case tests carried using experimental facility based coupling second modular vessel real time simulation software used components physically present experimental plant results significant improvement comparison available data experimental results presented different prime different operative conditions design part load operations moreover since manufacturers users usually able control air inlet temperature special attention devoted ambient temperature impact property strong influence performance machine reason empirical correlations ambient temperature effect obtained experiments objective perform easy implementation optimization tools experimental performance curves including several design conditions essential smart grid management implemented optimization tools allow find real optimal solutions tools based linear calculated correlations obtain results affected significant errors elsevier ltd rights reserved
acceleration development internet things big data importance high performance mass data retrieval gradually highlighted cloud computing distributed data calculation model suitable big data widely used paper firstly technology cloud computing introduced secondly retrieval technology mass data analyzed finally high performance retrieval method mass data based hadoop proposed architecture method composed mapreduce divided four layers bottom top access layer interface layer management layer storage layer
average consensus widely used algorithm distributed computing control agents network constantly communicate update states order achieve agreement approach result undesirable disclosure information initial state agent agents paper propose privacy preserving average consensus algorithm guarantee privacy initial state asymptotic consensus exact average initial values adding random noises consensus process characterize mean square convergence rate consensus algorithm derive covariance matrix maximum likelihood estimate initial state moreover prove proposed algorithm optimal sense disclose information necessary achieve average consensus numerical example provided illustrate effectiveness proposed design
combination effect novel inhibitor epidermal growth factor receptor tyrosine kinase inhibitor egfr non small cell lung cancer cells egfr activating mutations investigated combination showed synergistic effects mediated egfr resistant cells cases combination markedly suppressed although expression similar regardless treatment control cells receptor tyrosine kinase array profiling demonstrated suppressed met cells combined treatment showed tumor shrinkage compared drug monotherapy western blotting revealed tumor samples inhibited results suggest met suppression play role overcoming egfr resistance mediated cells conclusion combined egfr potent strategy mediated egfr resistance elsevier inc rights reserved
broader scale cell density localization colorectal cancer liver metastases prognostic predictive implications cell distribution higher resolutions fully investigated detailed resolution analysis cell distribution performed patient tissues divided distance classes tumor border adjacent normal liver thereby distinct density patterns cell localization relation malignant tissue detected distance tumor decrease cells common within area cytotoxic cells found significantly reduced macrophages increased identified close contact cells data suggests physical functional border within region survival analysis revealed improved overall survival patients high cells numbers direct tumor border interestingly decreased cells region also found significantly associated improved survival consequently detailed localization cells despite blockade associated improved clinical outcome high resolution analysis represents new insights relevant cell distributions especially related clinical responses paradoxical observation localization dependent prognostic relevance cell densities detectable detailed spatial analyses investigation spatial profiles higher resolutions suggested new biomarker survival response therapies
whether encoding variability facilitates memory shown depend whether item specific relational processing performed across study blocks whether study items weakly strongly related variable processing groups studied word list using item specific task using relational task variable task groups two different study tasks recruited type processing block repeated task groups performed study task block recall recognition greatest variable processing group weakly related lists variable processing benefit also found task based processing list type processing complementary item specific processing related list rather redundant relational processing related list performing item specific relational processing across trials within trial yields encoding variability benefits help decades contradictory findings area published elsevier inc
introduction connective tissue growth factor shown previously expressed high proportion paediatric precursor cell acute lymphoblastic pre suggesting potential oncogenic role tumour type therefore assessed mrna transcript diversity lineage using primary patient specimens cell lines methods mrna expression evaluated quantitative real time pcr northern blotting performed structural analysis mrna nested reverse transcriptase pcr examined protein diversity immunoblotting results northern blot analysis pre cell lines revealed short transcripts expressed association active phase cellular growth structural analysis confirmed synthesis several novel mrna isoforms lineage cell lines uniformly characterised retention coding sequence terminal domain one novel expressed majority primary pre patient specimens positive canonical mrna evidence alternative transcripts coding potential provided proteins predicted size detected immunoblotting conclusion study identifies first time alternative splicing gene shows short splice variant associated cell proliferation expressed cases primary positive pre novel variant encoding domain play role pre tumorigenesis progression elsevier ltd rights reserved
study objective identify factors contribute pregnancies reported sterilization worldwide design retrospective review commercial data compiled database medical literature manufacturer reports received commercial distribution sterilization micro canadian classification descriptive study measurements main results sterilization kits distributed worldwide pregnancies reported estimated user population based number distributed kits data sufficient enable analysis pregnancies potential contributing factors showed associated patient physician confirmation tests conceptions deemed occurred within weeks procedure therefore early detection identified cases conclusion although limitations dataset study design retrospective represents largest body cumulative sterilization data available date pregnancies reported apparent prevented greater patient clinician attention contraceptive use counseling rigorous evaluation informed interpretation procedure confirmation tests although estimated pregnancy rate based dataset likely suggest field performance sterilization micro consistent labeled age adjusted effectiveness years rights reserved
todays highly network society demand big data processing frameworks continuously growing widely adopted model process big data parallel distributed computing paper documents significant progress achieved field distributed computing frameworks particularly apache top level project apache software foundation based bulk synchronous parallel processing comparative studies empirical evaluations performed paper reveal potential efficacy big data applications particular present benchmark evaluation graph package apache using algorithm results show performance better terms scalability computational speed however despite great progress number challenging issues continue inhibit full potential used large scale paper also describes challenges analyzes solutions proposed overcome highlights research opportunities
service pattern cloud environment usually aims cross disciplinary cooperation creating value together customers becomes increasingly prevalent software process kind software development management strategy defined series activities implemented software life cycle provides set rules various phases software engineering achieve desired objectives current software development cycle getting shorter facing frequent needs change competition new resource management pattern proposed respond issues introducing service agile software development software process user oriented resource scheduling method proposed rational use various resources process maximizing benefits parties experimental results proposed pattern resources scheduling method reduces greatly resource project resource manager increases team resource utilization rate greatly improves software process delivers software products quickly pattern
letter presents three phase voltage source inverter topology reduce common mode voltage electromagnetic interference electric motor drives instead using filters active passive specific pulse width modulated pwm techniques reduce voltage proposed topology inherently less voltage generation addition two switches placed series lines topology effectively reduces voltage zero switching states floating inverter source topology implemented pwm method add additional complexity standard control techniques operation reduction capability topology first demonstrated simulation verified experimental results comparison common mode voltage made conventional three phase demonstrate effectiveness proposed topology
paper proposes embedding resistive random access memory microcontroller unit data buffer communicating stand alone flash memory study chip manufactured using combination tsmc process industrial technology research institute back end line process equipped novel sense amplifier three times reference cell current increasing read yield furthermore controller included built self test built self repair shortened error correlating code asymmetric coding yield approximately compared conventional dynamic random access memory buffer proposed architecture reduces system execution time power consumption mhz simulations also showed buffering runs least faster compared use memories ram phase change ram conduct bridge ram although buffering just competitive speed power consumption spin transfer torque ram buffering clear advantages area cost reliability
introduction rare form yet increasing prevalence united states rising rate various presentations including urinary incontinence case presentation year old woman presented urine leakage third delivery treated mixed urinary incontinence overactive bladder medications continued complaints urine leakage patient noticed symptoms urine leakage improved used menstrual confirmation patient underwent robotic assisted surgery symptoms urine leakage resolved conclusions evaluating women urinary incontinence history use menstrual aid diagnosis robotic assisted laparoscopic repair tissue efficacious minimally invasive method treatment
purpose paper aims present system framework classifying different models military based sound produce design methodology approach technique based extracting compact feature set two features extracted frequency domain sound signals produced engines namely spectral signal bandwidth features introduced artificial neural network classify aircraft signals findings current system identifies aircraft type among four military phantom experimental results show aforementioned types accurately classified per cent via proposed method practical implications proposed system used low cost tool already existing radar systems avoid cases missed detection false alarm importantly method used use stealth technology detected using radar devices originality value proposed method constitutes novel approach classifying military based sound signature utilizes two spectral features extracted sound aircraft engine features introduced neural network classifier
background temporary permanent cognitive changes following transient ischemic attack minor stroke described previously unknown cognitive deficits patients correlated acute infarction identified using magnetic resonance imaging aims tested hypothesis persistent cognitive impairment transient ischemic attack minor stroke predicted volume diffusion weighted imaging lesions methods acute transient ischemic attack minor stroke stroke scale patients prospectively recruited within onset patients underwent cognitive assessment magnetic resonance imaging including diffusion weighted imaging fluid attenuated inverse recovery sequences baseline days cognitive testing repeated day diffusion weighted imaging lesion fluid attenuated inverse recovery chronic white matter volumes measured cognitive impairment defined priori cognitive assessment score results one hundred fifteen patients median inter quartile range onset acute ischemic lesions present patients cognitive impairment rates similar patients without diffusion weighted imaging lesions although linear regression indicated relationship acute diffusion weighted imaging lesion volume day cognitive assessment scores white matter volumes baseline predictive persistent cognitive deficits days conclusions transient ischemic attack minor stroke patients suffer acute cognitive impairment post event deficits temporary deficits days onset correlated chronic white matter suggesting subclinical cognitive impairment impaired ability compensate effects acute ischemic
feasibility peptide nanotubes oral gene delivery carriers investigated mice eight doses days intervals association dna stability associated dna vitro permeability dna estimated results showed self associated concentrations plasmid dna associated binding constant calculated fluorescence quenching assay able protect dna acid bile digestion min min min respectively vitro apparent permeability coefficient calculated steady state flux increased dna formulation formulated found energy dependent process furthermore beta beta activity tissues quantitatively assessed using red beta significantly increased kidneys stomach liver respectively first dose oral delivery formulation organs beta activity confirmed presence dna southern blotting analysis intracellular tracing labeled dna presence mrna reverse transcription real time quantitative pcr qpcr another plasmid encoding luciferase used confirm results increased mrna luciferase stomach liver kidney detected qpcr vivo imaging luciferase activity quantification immunostaining respectively
three genes relevant phosphate pathway overexpressed leading increase production transcriptional levels significantly increased compared control strain intracellular nadph ratios cells grown increased respectively indicating overexpression carbon flux intracellular nadph ratio grown similar suggesting nadph produced quickly consumed production produced cultivation fed batch fermentation respectively addition grew fast dry cell weight reached whereas start strain reached fermentation yield glucose reached results demonstrate carbon flux efficient approach enhance production international union biochemistry molecular biology inc volume number pages
purpose purpose study evaluate effect different reconstruction plates screw combinations stress distribution using finite element analysis methods lateral lateral central defects simulated computer aided design modeling straight angular titanium reconstruction plates holes defects holes defects modeled screw diameter length total different screw placement combinations created force used present model unilateral molar data obtained finite element analysis recorded von maximum principle minimum principle stress values results observed stress values neck screw higher close resection area first screw stress plate body remaining increased principle stress values within tolerance limits bone conclusion highest stress observed nearest resection edge therefore important place screw adjacent resection edge
background infections multidrug resistant gram negative bacteria continuously growing pose challenge health institution globally resistant cre identified one limited treatment options higher mortality compared sensitive strains report increased burden cre fecal hospital north eastern region malaysia methods retrospective descriptive study august december conducted medical microbiology laboratory hospital malaysia tertiary teaching hospital beds hospital patients various medical surgical conditions suspected cre clinical specimens received laboratory identified confirmed using standard protocols polymerase chain reaction pcr assay performed determine genotype results altogether isolated various clinical specimens study period cre majority isolated cre predominant species cre mainly isolated rectal screening urine blood one hundred thirty six isolates subjected genotype determination showed positive detection new beta gene conclusion study noted high numbers cre isolated especially rectal active screening results significant cost pressures therefore revised especially low resource settings
achieve energy conservation prompt responses simultaneously paper propose novel energy saving data placement strategy called based energy aware sea applied structured storage systems save energy providing quick responses illustrate effectiveness sea implement two sea powered based data placement algorithms incorporating sea strategy respectively extensive experimental results demonstrate compared three known data placement algorithms greedy reduce mean response time average least saving energy average less respectively
human resources backbone system key functions effectively perform different immunization supply chain todays complex operating environment increasing strain caused new vaccines expanding immunization programmes source order drive change required sustainability continuous improvement every immunization supply chain needs effective leader dedicated competent immunization supply chain leader adequate numbers skilled motivated personnel levels health system overcome existing emerging immunization supply chain challenges without effective supply chain leader supported capable motivated staff none interventions designed strengthen supply chain effective sustainable source alliance strategy landscape analysis preceded evidence review march served inform global partner strategies country activities highlight support required study also aimed define status order create form baseline measure impact interventions related going forward analysis comprised comprehensive review survey respondents countries consultations practitioners several findings highlight key areas inform capacity development plan time revealed positive examples countries actively addressing issues identified place mechanisms structures optimize function published elsevier ltd
residual carbon ammonium municipal wastewater treatment plant tail water lead prejudice operation life time reverse membrane study new combined treatment system fix bed membrane developed pilot scale tested days removal residual carbon ammonium tail water results showed mean maximum cod ammonium removal efficiencies achieved optimum dosage single contribution cod removal ammonium removal removal respectively high throughput sequencing data showed rich bacterial populations species dominant reactors addition species bacteria increased significantly species bacteria increased remarkably mainly contribute carbon removal respectively aerobic ammonia bacteria nitrite bacteria bacteria existed reactors main reasons high removal efficiency ammonium system elsevier rights reserved
paper first presents novel dual layer permanent magnet excited synchronous motor extra set iron teeth employed inner stator rotor shaft provide additional variation magnetic reluctance along direction air gap strength flux modulation among magnetic fields produced windings improved proposed motor integrated two pairs flux modulated motors inside one frame one shared set windings advantage proposed motor offers much higher torque capability conventional counterparts making competitive low speed high torque applications paper novel triple layer excited synchronous motor presented similar operating principle three layers inside frame finite element method magnetic field mechanical motion coupled computation employed evaluate electromagnetic torque precisely proposed motor output extra torque compared conventional synchronous motor proposed motor output additional torque similar power efficiency compared conventional synchronous motor
steady free surface flows produce sudden changes height velocity namely standing supercritical flows standing traditionally observed studied experimentally water order mimic various hydraulic configurations instance vicinity energy recently studies emerged investigate standing formed flows dry granular materials relevant design protection dams present paper present new explicit relation prediction height standing demonstrate robustness new relation proposed cross comparing great number data sets standing formed water flows horizontal inclined smooth beds water flows horizontal rough beds flows dry granular materials smooth study reveals limits traditional one one relation depth ratio jump number incoming supercritical flow namely equation latter rankine relation take account gravitational frictional forces acting within jump volume jump length possible density change across jump incoming fluid newly proposed relation exact grains reasonable approximation water solve issues however relation predict height standing jump another length scale namely length jump known conclude study discussing empirical simple closure relations get reasonable estimate jump length water flows dry granular flows closure relations used feed general jump relation predict accuracy heights number situations provided calibrated friction laws described present study considered
family company highly integrated soc system architecture based cpu optimized communication industrial automation offers migration strategy field bus real time besides cpu couple communication channels integrated chip contribution describes study goal test usability according solving dsp tasks
phenomena false water level steam generator produces difficult control water level steam generator presently three element controller cascade configuration two pid controllers widely used demonstrated method effective fast responsive however major problem dynamic condition parameters two pid controllers determined easily improved single neuron adaptive pid control strategy adopts proportional coefficient exponentially adaptively according error presented simulation results show feed water control system based improved single neuron adaptive pid controller faster response speed shorter regulate time smaller oscillation improves dynamic performance
human left inferior parietal plays pivotal role many cognitive functions important node default mode network although many previous studies proposed different schemes detailed functional organization exact correspondence remain unclear mounting evidence indicates spontaneous fluctuations brain strongly associated cognitive performance behavioral level however whether consistent functional topographic organization rest task revealed remains unknown used resting state functional connectivity task related patterns separately identified seven four located gyrus three located angular gyrus specific networks functional characterization revealed four anterior found primarily involved sensorimotor processing movement inhibitory control perception speech processing social cognition whereas three posterior mainly involved episodic memory semantic processing spatial cognition results revealed detailed functional organization suggested functionally heterogeneous area addition present study demonstrated functional architecture rest corresponds found task processing periodicals inc
thermal hydraulic response large dry water reactor loss coolant accident conditions particularly respect pressure pool temperature crucial risk informed decision making generic safety issue texas university developed models several computer codes including model scenarios best estimate thermal hydraulic severe accident code created actively maintained national laboratories nuclear regulatory commission thermal hydraulic software package meant design licensing safety calculations among systems nuclear power plant developed maintained numerical applications inc electronic power research institute overarching goal analyses presented twofold produce best estimate time profiles pool temperature double ended break conditions investigate differences code results via sensitivity study pool temperature selected key parameter compare direct implications pool chemistry residual heat removal recirculation pressure drop across screens aspects modeling strategies discussed best estimates thermal hydraulic response presented significant code predictions hypotheses explain differences tested comparative code sensitivity study context sensitivity refers thermal hydraulics respond differences code inputs code phenomenological models sensitivity calculations performed exclude individually model effects comparative thermal hydraulic responses fan thermal surface condensation films break source definition calculations also performed multiple models excluded using pool temperature indicator physics terms code agreement thermal surfaces condensation film phenomena whereas fan models minimal effect spray exclusion results parts event sequence break source definition break effluent models lead
integration python language computer aided design simulation applications considered example physically correct optical simulation application approach based unified entity interface domain objects proposed particular scheme proposed extend application new types parametric objects writing extension classes simple structure special attention paid making api user friendly ensuring compliance object oriented programming principles
paper concerns effect stochastic resonance vibration isolation system rather reducing transmitted force shown possible significantly mask component force transmitted though system excited achieved adding low intensity random noise harmonic excitation force nonlinear mechanical vibration isolation system used study consists vertical linear spring parallel two horizontal springs configured potential energy system double prior analytical numerical study experiment demonstrate stochastic resonance mechanical system described elsevier ltd rights reserved
statistical analysis inter comparison solar radiation two sites representing two different climate regimes island plain coastal location covering period january december presented mean annual mean monthly daily global horizontal beam diffuse radiation frequency distribution sites computed discussed values coefficients used define frequency distribution type radiation parameters monthly basis statistical analysis extended daily index diffuse ratio ratio horizontal beam global radiation furthermore influencing factors magnitude radiation components examined value used classify three different types days clear partially days statistical analysis solar radiation components performed average annual basis days classified either clear partially stations additionally influence atmospheric absorption scattering solar radiation clear examined basis turbidity factor results analysis used characterize compare radiation regimes two sites sites relatively high intensity global direct horizontal radiation annual average daily global radiation intensity horizontal beam radiation therefore fraction beam component global radiation comparatively high sites indicated annual average daily fraction greater generally slightly higher rates global radiation indicated average yearly cumulative global irradiation elsevier ltd rights reserved
aim study examine association borderline personality traits cannabis use participants college students males females mean age males mean age females completed self report questionnaires assessing cannabis use borderline personality traits problematic cannabis use depressive symptoms borderline traits significantly inter correlated logistic regression analysis showed borderline traits contributed significantly cannabis use total sample multiple regression analysis showed traits positively uniquely associated problematic cannabis use symptoms among users results imply traits risk factor initiating use facilitate development problematic use symptoms among users study showed necessity taking account traits exploring relationships depressive symptoms borderline traits cannabis use elsevier ltd rights reserved
achieve enhanced biological response controlled degradation magnesium alloy modified biodegradable polymer coating called pcl fabricated thermal approach heat treatment neither alters chemical composition pcl membrane rate magnesium ion release value weight loss compared untreated sample changes oxygen content heat treated pcl coating improve mechanical adhesion strength coating magnesium substrate also enhance biological properties moreover thermally modified sample lead higher spreading elongation osteoblasts due enhanced functional group ratio analyses tomography one four weeks total volume new bone formation heat treated sample higher untreated controls respectively surprisingly modulus newly formed bone adjacent heat treated sample approximate higher controls promising results reveal clinical potential modified pcl coating magnesium alloy orthopedic applications
quantitatively image doping concentration capacitance high voltage lateral metal oxide semiconductor transistor device channel length ghz frequency using scanning microwave microscopy transistor embedded deep forming flat junction substrate shape junction resolved images calibrated imaging device revealed doping concentration values range atoms including body drift region source diffusion junctions silicon oxide interfaces minimum feature size electrical resolution doping concentrations compared technology computer aided design simulations resulting quantitative agreement model experiment images acquired different tip bias voltages allowing determine polarity reflection scattering signal calibrated capacitance measurements obtained various transistor regions range results suggest profiling capacitance measurements used quantitative nanoscale semiconductor device imaging
attracted significant attention energy conversion storage materials especially promising metal free oxide catalyst new kind electrode material however poor electronic transport ability hinders application thus improvement electronic transport ability essential enhance electron transfer catalyst active sites electrode effective avoid potential drop consequently energy loss work high quality growth deficiency films obtained simple low cost polymer assisted deposition method found room temperature conductivity sigma doping increases nearly ten times compared parent oxygen content driven enhancement conductivity discussed oriented film suggested existence substrate beneficial stabilize deficiency compound site deficiency extends range oxygen content strain including strain doping induced chemical strain annealing temperature oxygen content resulting oxygen independence ambient conditions high conductivity following process conductivity electronic state related material tuned practical application
rainwater harvesting rwh decentralized practice provides water supply runoff reduction benefits often difficult assess assist evaluation model developed simulates single rwh system using storage volume roof area irrigated area indoor demand storage goal independent design variables water supply runoff capture reliability assessed wide variety cases tradeoff curves developed evaluate design variable substitution reliability held constant reliability function fit simulation results solution method developed solve unknown variable function others method evaluates different design cases provide water supply runoff reliability demonstrating design variables substituted using care restrict substitutions functional inputs separately functional outputs method provide guidance designers selecting equivalent rwh systems regulators assessing runoff reduction goals results indicate goal enhances runoff capture reliability reduces water supply reliability moderately increases storage volume increased water supply runoff capture reliability irrigated area much larger negative effect water supply reliability roof area similar negative effect runoff capture reliability irrigated area increases population runoff capture reliability increases eventually remains constant reflecting dominance indoor demand turn reflects simulations assumption seasonal irrigation applications indicate land uses provide larger demands offices commercial sites high density residential sites better suited lower density residential lots rwh commonly employed
paper presents application signal flow graphs sfg calculation higher order derivatives sensitivities linear circuit functions idea exact differentiation circuit functions based networks translated sfg language thanks application possible calculate exact value order derivative circuit function without knowing function explicit form moreover derivatives determined basis analysis two graphs circuits original one show sfg approach sensitivity calculation allows reduce greatly complexity calculations copyright john wiley sons ltd
rainwater harvesting rwh promising tool surface water groundwater supply overcome imbalance water supply demand changing climatic conditions main aim study present technically robust pragmatic methodology evaluating rainwater harvesting potential identifying suitable sites rwh artificial recharge structures using geographic information system gis based multi criteria decision analysis unlike past studies study proposes approach prioritize zones sites rwh recharge structures great importance effective implementation rwh strategies derived themes runoff coefficient basic themes slope drainage density used mapping rainwater harvesting potential thereafter suitable zones sites feasible rwh recharge structures identified using suitability criteria gis based boolean logic addition identified zones sites prioritized based themes key factors viz post groundwater level groundwater fluctuation water demand weights themes features themes integrated gis environment study area divided four rwh potential zones study area falling high moderate rwh potential respectively hand study area classified four rainwater harvesting demand zones namely high study area high moderate low zones suitable constructing farm ponds cover tanks ground cover sites tanks along streams sites check dams also identified suitable locations study area framework prioritization suitable zones sites rwh groundwater recharge proposed study integrating rainwater harvesting potential rainwater harvesting demand maps integrated approach time saving cost effective also helpful efficient planning management rainwater larger scale elsevier ltd rights reserved
first introduced egypt highly pathogenic avian influenza resulted death millions birds caused infections least deaths humans decade viral circulation outbreaks continue occur diffusion mechanisms poultry farms remain unclear using landscape genetics techniques identify distance models strongly correlated genetic relatedness viruses suggesting likely methods viral diffusion within poultry using viral genetic sequences obtained infected birds throughout northern egypt calculated genetic viruses eight gene segments spatial correlation evaluated using tests multiple regression distance matrices within causal modeling relative support frameworks tests examine spatial patterns genetic relatedness compare different models distance four models evaluated euclidean distance road network distance road network distance via markets least cost path model designed approximate wild travel using niche modeling circuit theory samples farms strongly correlated least cost path distances samples commercial farms strongly correlated road network distances results largely consistent across gene segments results suggest wild birds play important role viral diffusion farms commercial farms experience human mediated diffusion results inform avian influenza surveillance intervention strategies egypt elsevier rights
present work compare results obtained two approaches detect receptor expression cells surface confocal laser scanning microscopy established methodology study cell biology associated events wherein cells molecules labeling needed alternative label free technique essentially quantitative based electrochemical impedance spectroscopy eis concerning specificity assays equivalent since depend antibody efficiency recognize discriminate searched structure cell context regarding sensitivity showed case detection toll like receptor transfected human cells label free eis approach measurements performed environment retained morphology antigenic sites cells sensitive receptor detection demonstration proposed electrical impedance analytical assays help optimizing ability evaluate cellular biological events provides medical community alternative either analytical tool applied biological model interest used design perform rapid methodology elsevier rights reserved
paper proposes simple approach measure joint angle using coupling system directly whereas traditional methods involved either complex machine learning task arm movement models consideration model parameters accurate often first correlation data established defining polynomial function based simple six impedance model human upper arm theta achieved moving along sagittal transverse planes different loads empty hand coefficients polynomial estimated based polynomial fit technique actual angles reference frame calculated using motion data total eleven subjects seven males four females age years considered experiment however data eight subjects used derive correlation exclusively furthermore influence muscle fatigue different loads derived correlation studied next based derived correlation measured two parts inside outside tests considering six subjects results show proposed idea measure effectively error degrees moreover performance comparison proposed approach shows compatibility indicating low complexity higher accuracy easy measure
tissues source mesenchymal stem cells harvested low cost veterinary field man stem cells derived tissues express plasticity reduced immunogenicity high anti inflammatory potential making promising candidates treatment many diseases umbilical cord mesenchymal cells isolated characterized different species recently investigated potential candidates regenerative medicine study cells derived bovine isolated first time enzymatic methods frozen cultivated least characterized derived cells readily attached plastic culture displaying typical fibroblast like morphology although proliferative capacity decreased passage cells showed mean time hours mean frequency one colony forming unit fibroblast like every cells results molecular biology studies flow cytometry analyses revealed derived cells showed typical antigen profile mesenchymal stem cells positive oct myc negative remarkably derived cells showed differentiation ability culture induced media derived cells able differentiate osteogenic neurogenic lines shown positive staining expression specific markers polymerase chain reaction analysis cells negative mhc positive mhc thus reinforcing role tissue source bovine cell based therapies results provide evidence bovine derived cells potential differentiate repair damaged tissues reinforce importance tissues stem cell sources veterinary regenerative medicine detailed evaluation immunologic properties necessary better understand potential role cellular therapy elsevier inc rights reserved
liquid spontaneously radial pattern even rest fluid flows observed utilized biological research origins studied particle tracking measure velocities radial fluid flows shown linked evaporation used infrared thermal used identify thermal gradients air liquid interface bottom two color confocal imaging used measure thermal gradients vertical direction within fluid finite element model fluid incorporating measured temperature profiles shows forces sufficient produce flows consistent measured particle velocity results flows arise plate formats impact biological research positive negative ways american institute chemical engineers
background due popularity public service broader health social associated illicit drug use study sought investigate drug prevention messages found government campaign understood experienced engaged among group street involved young people canada methods qualitative interviews conducted individuals enrolled risk youth study thematic analysis conducted results findings indicate campaigns messages neither risk youth provided information resources support cases messaging exacerbated social suffering experienced individuals conclusions study underscores importance rigorous evaluation need consider allocated drug prevention campaigns social services address structural drivers drug related among vulnerable youth populations
study investigates change multiple parameters three valley type located basin sharing climatic regime assesses control factors response satellite remote sensing data landsat along digital elevation model used extraction parameters results show lost area remained relatively stable rate area loss however results surface ice velocities change surface elevation change suggest comparable slowing surface lowering debris cover also varied substantially results reveal higher associated higher range slow lower ablation zones debris cover found controlled slope higher rates higher upper ablation zone coupled lower surface lowering primarily governed slope gradient differential surface lowering size accumulation zone results confirm presence zones lower upstream upstream major indicating expansion zones surface lowering seemed influenced ice flux changing spatial distribution debris cover presence lakes ice melting around lakes ice prime reasons behind intense mass loss observed zone surface lowering similar higher wide thinning differential surface lowering reduced surface gradient hence also rapid surface gradient changes indicate possible development lakes future interestingly despite close proximity demonstrate three distinct ablation patterns role factors overall study states mutual variation parameters together factors exercise great control response elsevier rights reserved
minimizing working time internal combustion engine important method hybrid electric vehicles save energy reduce emissions however vibrations caused frequent engine starts comfort especially power split hybrid vehicles decoupled device engine transmission vibrations transfer powertrain car body engine also system hardware test results show longitudinal vibration track severe maximum peak peak acceleration study dynamic models system powertrain mounting system respectively established detail natural characteristic analyses two dynamic models reveal engine order vibrations stimulate series low frequency engine starts finally embodied car body vibrations two dynamic models coupled together analyze transient dynamic characteristics associated engine starts evident simulations longitudinal vibration car body mainly transferred whereas vertical vibration car body mainly transferred powertrain mounting system besides initial position gasoline engine obvious effect engine order vibration results different transient responses full vehicle system
background compared chemotherapy significant improvement survival outcomes programmed death receptor inhibitors programmed death ligand inhibitor shown several types advanced solid tumors conducted systematic review meta analysis compare safety tolerability inhibitors chemotherapy methods pubmed american society clinical oncology databases searched september eligible studies included randomized controlled trials rcts comparing single agent food drug administration approved inhibitors chemotherapy cancer patients reporting grade high grade adverse events aes high grade treatment related symptoms hematologic toxicities immune related aes treatment discontinuation due toxicities treatment related deaths summary incidence relative risk confidence intervals calculated results total patients rcts included meta analysis trials underlying malignancies included non small cell lung cancer trials melanoma trials compared chemotherapy inhibitors significantly lower risk high grade fatigue sensory neuropathy diarrhea hematologic toxicities grade anorexia nausea constipation high grade aes treatment discontinuation increased risk grade rash pruritus colitis aminotransferase elevations hypothyroidism hyperthyroidism high grade inhibitors conclusion inhibitors overall better tolerated chemotherapy results provide evidence supporting favorable risk benefit ratio inhibitors
natural frequencies vibration corresponding mode shapes suspension bridge varying bending stiffness cables determined changes occur characteristics respect parametric changes bridge examined single span suspension steel flexible cables selected initial model used study dynamic characteristics suspension system based fea parameter studies presented vibration characteristics studied function structural material parameters cable flexural stiffness modulus elasticity mass density structural components generally found main cable bending stiffness contributes considerable effect natural frequencies suspension system
serious labor construction industry emerged china recent years led significant need industry improve poor inferior conditions living workers applying technical management methods order address problem improving rural construction workers urban china paper uses modular construction technology develop innovative integrated system construction workers site current status traditional construction workers investigated reveal urgent problems terms health safety environmental considerations analyzing barriers block innovation improved workers integrated system proposed detail design operational management mode taken account developed system provide comfortable living conditions site workers lower residential density safer higher quality lifestyle case study real world pilot project china studied validate economic feasibility applicability innovative integrated system results indicate workers pay per day daily income use integrated quarter system developed system provides novel construction management mode practitioners industry increase productivity project due reduced physical mental health problems workers suggested developed system business mode promoted regions large numbers construction workers
offshore wind turbines incorporating electrical generators converters operate locations accessibility lead long mean times repair maintenance therefore essential cost effective availability targets reached yet condition monitoring techniques appropriate offshore turbines resolved reliability studies shown majority failure modes wind turbines concentrated drive train including electrical generator converter heavily affected wind conditions test rig constructed features similar wind turbine drive train enable development signal processing techniques necessary variable speed high torque variation application test rig includes low speed shaft high speed shaft electrical generator driven simulated wind conditions test rig also used inform selection appropriate monitoring instrumentation offshore wind turbines series condition monitoring approaches investigated test rig using measured torque speed shaft displacement vibration detect faults use appropriate signal processing techniques chances load conditions properties cod faults detected
paper discusses contradictory contemporary australian notions controversy diversity relate subjects genders common view gender sexuality important features identity society politics consistent effort made australian educational context combat discrimination prejudice sexually gender diverse people however states commitment diversity policies balanced secondary focus hostile non expression view expression inherently political nature therefore inappropriate school setting australia arguably demonstrated dilemma recently two notable controversies intervention planned school baby exploring experience children sex families media trans positive teaching kit using case studies paper explores competing controversy diversity tendency lives experiences people becoming consequently arguably detrimental meaningful participation people social citizens
multi label learning draws great interests many real world applications highly costly task assign many labels oracle one instance meanwhile also hard build good model without diagnosing discriminative labels reduce label costs improve ability train good model multi label learning simultaneously active learning addresses less training samples problem querying valuable samples achieve better performance little costs multi label active learning researches done querying relevant labels less training samples querying labels without diagnosing discriminative information effectively handle labels measurement uncertainty since maximum criterion provides robust analysis outliers many machine learning data mining algorithms paper derive robust multi label active learning algorithm based merging uncertainty propose efficient alternating optimization method solve method eliminate influence labels discriminative measure uncertainty make improvement ability information measurement uncertainty prediction labels unknown data enhance uncertainty also improve similarity measurement multi label data labels information experiments benchmark multi label data sets shown superior performance state art methods
article discuss categories work politics education human work category seek understand policy training human foundations necessary formation social starting produced work category historically implementation conditions possibilities development fundamental complex formation social removal natural barriers wake demonstrates double transformation mediated work human metabolism nature occurs training materials social historical human becoming basis social therefore also discuss antisocial character private property state therefore policy uncover origin social problems essence politics according one half activity historically instrumental something overcome conception politics state understanding dimension human social structurally
patients eating disorders risk electrolyte imbalances lead life threatening complications timely recognition evaluation electrolyte abnormalities including essential case report describe uncommon etiology patient disordered eating society adolescent health medicine rights reserved
great east japan earthquake occurred march damaged nuclear power plant caused prolonged station following reactor water level gradually dropped due increase steam discharge safety relief valves eventually led nuclear fuel melt almost four years passed since accident official reports japanese regulatory given general description causes fatal accident even accident nuclear power plants currently operating units construction worldwide fact alone extremely important learn accident enhance safety culture reactor operation completely eliminate possibilities catastrophic accidents seen study best estimate transient thermal hydraulics code utilized focus effectiveness isolation installed advanced water reactors ics turned one safety systems accident simple yet reliable safety system utilized secure possible reactor core damages present paper several case studies conducted utilizing ics presented methods countermeasures improve light water reactor safety level design operation features proposed elsevier ltd rights reserved
according israeli law citizens aged fulfill military reserve duty israeli defense forces guided theory conservation resources study examined association resource loss gain economic time familial work personal resources level reserve combat distress satisfaction service following termination reserve duty sample consisted male israeli citizens ages serving reserve using internet based questionnaire prior start reserve duty time respondents completed questionnaires assessing psychological traits social support psychological distress following reserve service period time respondents completed short inventory resource loss gain related service assessments psychological distress satisfaction service main results showed resource loss higher average resource gain associated positively distress negatively satisfaction service whereas resource gain positively associated satisfaction findings compatible theory point areas reserve assisted fulfilling task maintaining national security simultaneously preserving personal
personalized exchange inspired process speedup parallel distributed computing recently algorithms successfully applied multistage interconnection networks including baseline networks however routing algorithms relies switch patterns stage control sources half routing solution since perform full self routing protocol paper first propose full routing solution realizing class switch baseline etc embedded chip effectively self routing also stage switch control routing two embedded functions incorporate multi stage proposed optimal log default static function order optional dynamic function rho order counter second introduce fewer delay stages achieve ultimate embedding finally experimental results applying confirmed including based matrix log yields significant speedup elsevier inc rights reserved
intimate partner violence ipv teen dating violence widespread preventable public health problems united states children exposed ipv caregivers adolescent victims suffer immediate risks physical safety also long term health sequelae emergency department presents unique opportunity physicians screen various forms family violence intervene behalf victims screening ipv widely recommended national health organizations including american college emergency physicians effective screening protocols require multidisciplinary approach informed knowledge local community resources
regulation eukaryotic transcription vivo occurs distinct stages previous research identified many active transcription factors core transcription components studied functions vitro vivo nonetheless individual act regulate mrna gene expression single cell remains poorly understood direct observation assembly various biochemical reactions transcription single copy gene vivo ideal approach study problem research area requires developing novel techniques single cell transcription imaging integrating imaging studies understanding molecular biology transcription past decade advanced cell imaging enabled unprecedented capabilities visualize individual molecules track single transcription sites detect individual mrna fixed living cells studies raised several novel insights transcriptional regulation hit run model transcription obtained vitro biochemistry analysis point key question achieve deeper understandings discover novel mechanisms eukaryotic transcriptional regulation imaging transcription single cells meanwhile technical advancements likely required visualizing distinct kinetic steps transcription single copy gene vivo review article summarizes recent progress field describes challenges opportunities ahead elsevier ltd rights reserved
present study designed investigate relationship among epigenetic changes wnt antagonists histone expression tumor suppressor genes acute leukemia better understand pathogenesis leukemia quantitative reverse transcription polymerase chain reaction qrt pcr performed detect messenger rna mrna expression levels wnt antagonists patients normal controls sequencing performed detect methylation status promoter western blotting performed detect overall expression levels protein histone patients acute myeloid leukemia aml normal controls relationship protein expression histone analyzed chromatin immunoprecipitation qpcr chip qpcr performed investigate recruitment promoter coding regions results demonstrated expression levels wnt antagonists generally low aml showed differential expression acute lymphocytic leukemia cases aml methylation promoter observed protein expression low cases aml overall level protein higher normal controls addition expression positively correlated expression unrelated methylation status promoter moreover enriched promoter region coding region contrast expression unrelated expression normal controls moreover observed methylation wnt antagonists often found patients particularly aml whereas extent methylation variable patients expression positively correlated enrichment promoter coding regions increased expression promoting transcription initiation elongation
objectiveto evaluate effects parent reported medical home status health care utilization expenditures quality children data expenditure including total children followed survey study took causal difference differences approach using inverse probability weighting doubly robust estimators study changes medical home status year period affected childrens health care outcomes analysis adjusted childrens sociodemographic health insurance conducted sensitivity analyses using alternative statistical methods different approaches outliers missing data accounting possible common method biases principal children whose parents reported medical homes years medical homes year lost year significantly lower parent reported ratings health care quality higher utilization emergency care compared children whose parents reported medical homes years medical homes year gained year significantly higher ratings health care quality significant differences health care expenditures utilization medical home help improve health care quality children losing medical home lead higher utilization emergency care
one classic fields computer vision image categorization attracted widespread interests numerous algorithms proposed community many advanced state art however existing algorithms designed without consideration supply computing resources therefore dealing resource constrained tasks algorithms fail give satisfactory results paper provide comprehensive depth introduction recent developments research image categorization resource constraints large portion based work also give brief description algorithms furthermore make investigation recent developments deep neural networks focus resource constrained deep nets
background sepsis remains leading cause death intensive care units many deaths sepsis due infections patients entered immunosuppressive phase disorder one cause immunosuppression sepsis cell mediated programmed cell death interaction ligand studies demonstrated blocking interaction knockout mice inhibitory antibodies reversed cell dysfunction improved sepsis survival study assessed efficacy novel short acting peptide compound inhibits signaling clinically relevant second hit fungal sepsis model methods mice underwent ligation induce three days later mice received intravenous injection candida albicans forty eight hours candida infection mice treated compound inactive peptide effect candida infection expression molecules flow cytometry cells cells natural killer cells natural killer cells effect compound survival also examined results four days fungal infection expressions markedly increased cells septic versus sham operated mice versus versus compared control compound caused fold increase survival conclusions compound significantly improved survival clinically relevant immunosuppressive model sepsis results support therapy targeting cell lethal disease elsevier inc rights reserved
several novel dispersion engineered analog signal processing systems exploiting broadband dispersive characteristics design flexibility presented systems either guided wave wave systems employ either group velocity group velocity dispersion parameters systems presented frequency tunable impulse delay line pulse position modulator frequency real time fourier former pulse generators analog real time spectrum analyzer frequency resolved electrical gating spatio temporal effect analog true time represent new class impulse regime structures previously reported mostly restricted regime
several studies patients schizophrenia reported marked reduction sleep spindle activity investigate whether reduction linked genetic risk illness analysed sleep spindle activity healthy volunteers patients schizophrenia first degree relatives share enriched set schizophrenia susceptibility genes investigated correlation spindle activity cognitive function first degree relatives whether spindle abnormalities affect fast slow sleep investigated fast slow sleep spindle activity non rapid eye movement sleep total subjects comprising patients schizophrenia healthy first degree relatives healthy volunteers groups balanced age gender years education estimated verbal subsample relatives received additional testing memory performance compared healthy volunteers fast spindle density reduced patients schizophrenia healthy first degree relatives following pattern consistent assumed genetic load schizophrenia deficit spindle density specific fast associated decreased memory performance findings indicate familial occurrence phenotype thus support hypothesis deficient spindle activity relates genetic schizophrenia furthermore spindle reductions predict impaired cognitive function specific fast physiological marker investigated intermediate phenotype schizophrenia also constitute target drug development especially regard cognitive dysfunction
background variations genes regulate innate immunity responses associated susceptibility asthma atopy early life aim study evaluate association four different polymorphisms gene either alone combination post asthma allergies years age methods data single nucleotide polymorphisms snp available children polymorphisms associations asthma allergies studied preschool aged children hospitalized age months parents interviewed record childrens history asthma allergies infancy present results years mean asthma present children recurrent first years life present children fifty three study participants current atopy atopic eczema allergic rhinitis eight children combination current atopy genotype combinations twenty three children genotype present atopy versus genotypes years years age haplotype carriers asthma versus haplotype carriers conclusions polymorphisms seem associated elevated allergies recurrent risk later childhood early life wiley periodicals inc
ecological success social insects including tightly connected ability protect food resources exchange energy rich protect various natural fungal infection consequences partners wherein disease vectors behavioural responses towards fungus infected ant species nature studied studied behaviour four ant species towards von contaminated fungal pathogen field spp quickly detected removed infected host plant neither ant species degree specialization medium high number significant effects behaviour towards infected unlike usually displayed non aggressive behaviour tolerance collection immediate removal infected insects seem minimize probability infection behaviour play important role ant interactions preventive antifungal mechanism formed parasite pressure thus contributing ecological success
order get unbiased parameter estimation transfer function noisy input output data paper presents auxiliary model based method basic idea replace outputs information vector system auxiliary model outputs modify recursive least squares parameter estimation errors system output auxiliary model output proposed method improves precision parameter estimates wide application modelling control engineering without strict mathematical assumption finally advantages proposed approach shown simulation tests elsevier inc rights reserved
background risk indoor exposure volatile organic compounds microbial origin childhood symptoms rhinitis eczema doctor diagnosed asthma rhinitis eczema respectively remain unclear objective test hypotheses total sum microbial volatile organic compounds sigma poses independent risk doctor diagnosed asthma rhinitis eczema respectively multiple symptom presentation minimum two conditions case associated significant interaction absolute humidity additive scale methods case control investigation cases controls examined november march period air sampling air quality inspection health outcome results sigma also global index significantly higher within homes cases high compared controls low cases controls associated dose dependent increase exposure variables interest sigma per quartile increase cases controls among children live high homes natural log unit sigma associated times greater odds case status compared times odds outcome among low homes specifically joint exposure high high associated times greater odds doctor diagnosed asthma status conclusion joint occurrence high sigma significant increase case status asthma risks additive scale elsevier ltd rights reserved
one important borne viral diseases infection now becoming global concern due rapid spread rise incidence currently approved vaccine effective antiviral drug virus infection acid related derivatives reported inhibit broad spectrum viruses however unknown whether one derivatives affects infection found production infectious particles significantly decreased treatment permissive cells viral rna viral protein synthesis affected moreover results time addition study showed inhibitory effect exhibited targeting virus host cells directly resulted remarkable reduction virus virus furthermore rna progeny supernatants significantly decreased treatment dose dependent manner taken together data indicate antiviral activity mainly due effect exerted compound work first time demonstrates antiviral activity infection providing useful information development potential therapeutic interventions wiley periodicals inc
present work aims investigating infection linked methyl aspartate receptor dysfunction schizophrenia related disorders puts forward hypothesis immune responses involve indeed analysis proteome subunits peptide shows massive peptide overlap supports possibility anti immune responses raised active infection cross react host determining disruption neural circuits cognitive deficits particular nmda subunit mainly expressed positive appears potential induced cross reactive immune attacks
scale data structures designed support gradual content progressive transfer vector data use arbitrary map scales focus date server side especially convert geographic data proposed scale structures means automated paper contributes ongoing scale research focusing client side communication particularly works web services setting claimed functionalities urgently needed many web based applications desktop mobile require gradual content progressive transfer high performance level web client prototypes developed paper make possible assess behaviour scale data determine users actually see interactions several different options web services communication architectures possible scale setting options analysed tested various web client prototypes respect functionality ease implementation performance amount transmitted data response times show scale data structure fit current web based architectures efforts map distribution internet however benefits scale data client needs aware structure client needs map refined means gradual content operation missing data requested data sent client server way amount data transferred one time reduced shortening transmission time addition conceptual architecture aspects many implementation design decisions play also elaborated paper based experiments conducted conclude scale approach indeed supports gradual content progressive web transfer vector data big step forward making vector data arbitrary map scales available larger user groups international society photogrammetry remote sensing inc published elsevier rights reserved
paper novel transmitting scheme multiple input multiple output mimo satellite relay based multi user multi beam communications proposed considered multiple terrestrial relay nodes employ amplify forward improve reliability spectral efficiency satellite radio links zero forcing minimum mean square error mmse signal detection techniques employed established terrestrial wireless communication systems numerical results provided quantify performance gain proposed system configuration terms bit error rate channel capacity
targeted protein degradation using technology emerging novel therapeutic method address diseases driven aberrant expression disease causing protein molecules small molecules simultaneously bind target protein ubiquitin thus causing degradation target protein proteasome like small molecules possess good tissue distribution ability target intracellular proteins herein highlight advantages protein degradation using provide specific examples degradation offers therapeutic benefit classical enzyme inhibition degrade proteins regardless function includes currently proteome comprises approximately human proteins beneficial aspects protein degradation include ability target overexpressed mutated proteins potential demonstrate prolonged effect beyond drug exposure lastly due catalytic nature pre step potent molecules high degree degradation selectivity designed impressive preclinical vitro vivo data published data development clinically viable molecular weight falling range delivery bioavailability remain largest way clinic solving issues demonstrating proof concept clinical data focus many labs next years elsevier inc rights reserved
effect gfp transplantation evaluated experimental model parkinsons disease wistar rats three experimental groups control con injured les transplanted les order evaluate influence transplantation motor behavior one month injury rotation behavior induced neurological test bar cells positive developed using anova test decrease number turns transplanted animals neurological test transverse bar lead group intermediate position regarding les con groups possible recovery pathway gfp
computer programming technological part creative part involves specific technical aspects programming languages creative aspects find best solutions different problem domains programming learning process encompasses group different teacher student techniques put practice techniques object learning programming language solve real problems learning process include good software development practices analysis design novice disciplines developing quality software improve learning programming process use techniques methods software development adapting context courses programs curricula different methods help develop quality software article case study using personal software process method extreme programming techniques first programming course engineering students support learning process programming language acquiring good software development habits wiley periodicals inc
background nurses accept hiv infected colleagues continue patients provider patient transmission risks appropriately assessed aims assess factors associated nurses willingness accept hiv infected colleagues design descriptive cross sectional methods anonymous online survey targeting japanese nurses working hospitals clinics logistic regression analysis used evaluate factors associated willingness accept hiv positive colleagues risk assessment results respondents avoided contact expressed views hiv infected colleagues less willing accept appropriate risk assessment high level knowledge regarding hiv transmission increased likelihood acceptance towards hiv infected colleagues conclusions use risk assessment increase nurses willingness accept hiv infected colleagues particularly among workers high level knowledge hiv
smart material based actuators smart actuators known prominent characteristics high resolution positioning high bandwidth ease integration miniaturized systems however applications restricted inherent hysteresis nonlinearity paper presents new modified model rate dependent property proposed model directly used developing robust adaptive control order eliminate hysteresis effects finally efficacy designed control framework verified via real case giant actuator used testbed
generation national program established coordinate research development support development supercritical water cooled reactor concept provide safe economical clean power future undergone phases involving federal laboratories federal agencies academia majority work phase focused establishing infrastructure partners performing fundamental whereas phase focused applied support completing canadian concept given fundamental long term nature generation research canadian universities actively engaged addressing challenges nuclear reactor system canadian nuclear laboratories atomic energy canada limited played integral role achieving goals generation national program leading concept design effectively national laboratories natural resources canada national research council canada fostering innovative network development highly qualified people overall many test facilities constructed enhancing capabilities partners many technical papers published international journals large number highly qualified personnel trained nuclear non nuclear industries paper highlights unique collaborative structure key contributions canadian program generation international community
paper frequency domain modeling methodology applied various multi rotor aerial vehicles introduced primary contribution work systematic integration first principles modeling system identification approaches generate flight dynamics models good accuracy first principles modeling model linearization conducted obtain appropriate baseline model subsequent system identification next four step parameter identification process consists baseline model determination data collection preprocessing mode wise parameter identification model fidelity validation performed frequency domain identify uncertain parameters method applied two custom built multi rotor aircraft one type one efficiency demonstration
background college students high incidence unplanned pregnancies china highly raised public attention numerous reproductive health services provided college students study examined whether health services college lead contraceptive use among female college students heterosexual relationships methods self administered questionnaire survey cross sectional design administered among female students four colleges china identify health service factors associated contraceptive use past months results analysis revealed younger female students lower odds contraception use whereas students reported availability health related web sites likely use contraceptives female students reported contraceptives birth control counselling accessible college health services greater odds contraceptive usage finally provision contraceptives birth control counselling school associated greater odds contraceptive use conclusions contraceptive related health services play important role reducing unintended pregnancies directly addressing contraceptive needs female students programs provide targeted services help reduce high rates unexpected pregnancies among female students china
eye complex structure derived neural tube surface migratory neural crest origin structures evolve neural tube affected acid deficiency aim work investigate whether maternal acid deficient diet cause developmental alterations mouse eye mice weeks old assigned two different acid groups periods ranging weeks animals gestation day hepatic analyzed eyes fetuses studied anti transforming growth factor tgf anti tgf exposed deficient diet exhibited numerous eye macroscopic anomalies eye affected organ fetuses highest incidence malformations occurred week statistically significant linear association number maternal weeks deficient diet embryonic microscopic eye malformations observed optic derivatives structures forming eye anterior segment showed severe abnormalities addition tgf tgf expression eye also altered study suggests adequate acid status plays key role formation ocular tissues structures whereas vitamin deficiency negatively associated normal eye development even short term exposure wiley periodicals inc
introduction reflux disease possible cause chronic cough laparoscopic established treatment retrospective study operation associated cough examined possible preoperative predictive factors concerning post surgical therapy effect characterized patients methods patients laparoscopic due treated proton pump inhibitors without associated cough evaluated three month follow data analysis regarding indication point score typical symptoms findings histology hour results leading symptoms complete freedom complaints reached patients surgically group patients free cough months significant improvement unchanged cough higher values typical reflux symptoms therapy resistance proton pump inhibitors ppi clearly seen patients patients showed less reflux complaints lower ppi resistance frequent allergies significantly often acid taste patients subgroups mainly reflux mainly cough lowest values ppi resistance found subgroup diagnostics show differences groups although trend seen towards fewer bile reflux larger higher scores also smokers non allergic cough intervention conclusion patients reflux associated respiratory symptoms present entity good ppi therapy response cough considered often surgery since cough symptoms two thirds appropriately selected patients short time surgery laparoscopic surgery also considered aspects individual predictors success surgery sum relevant individual case history clinical criteria combined used score provide reliable indication surgery
brain inspired circuits provide alternative solution implement computing architectures taking advantage fault tolerance generalization ability logic gates brief advance threshold circuit configuration consisting averaging circuit combination operational amplifier cmos inverters application realizing complex computing circuits developed threshold logic gates used designing fast fourier transform multiplication circuits useful modern overall proposed threshold logic outperforms previous cmos logic cells every aspect however indicate lower chip area lower total harmonic distortion controllable leakage power higher power dissipation respect cmos logic
background latino youth particularly rural settings experience significant disparities rates teen pregnancy violence data available regarding social structural influences latino youths developmental trajectories specifically factors promote wellbeing protect engagement high risk sexual violence related behaviors methods forty two youth aged years old recruited middle schools youth leadership programs participate one eight community based focus groups predominantly latino urban center rural central coast focus groups covered youths experiences risk protective factors associated exposure violence romantic relationships four researchers completed coding grounded theory approach informed theoretical frameworks social ecological model social capital studys design participant recruitment informed community board local youth serving organizations health care providers results participants described family lives rich bonding social capital strong parents near peer family members reported parents strong desire promote behaviors social mobility often lacked bridging linking social capital required help youth structural systems college applications access health care youth also reported families link children negative social capital exposure affiliation conclusion adolescents agricultural community identified robust sources bonding social capital within families however identified limitations families capacities link structural resources education employment health care support behaviors upward social mobility
goal child health services merely treating even preventing childhood diseases disorders expanded promoting childrens optimal healthy development pediatrics evolved exclusive focus treatment illness opportunity promote childrens healthy development evolution profound implications content child health services programs system transformation public policy enhanced understanding impact social determinants childrens health developmental outcomes underscores importance evolving framework system transformation key policy implications
video demand popular application internet past years services shifted cloud although transformation introduces many benefits new challenges data security due storage cloud servers satisfying requirements fine grained access control cloud attribute based encryption algorithms applied field however due large number videos users cloud exist frequent behaviors numerous categories induce challenges higher flexibility efficiency existing schemes discuss challenges sufficiently paper propose based secure independent update concise expression access control scheme cloud provide flexible efficient authentication services aspect access policy update guarantee users affect design independent update key policy algorithm allows users update keys separately existing schemes require members group updated simultaneously aspect attribute description reduce storage cost propose concise expression access structure describe various logic relationships flexibly efficiently security proved standard model experiment implemented pairing based cryptography library theoretical analysis experimental results show scheme efficient effective services cloud elsevier inc rights reserved
paper binary bell polynomials employed find bilinear form bilinear backlund transformation lax pair dimensional equation based bilinear form three wave method multi soliton solutions presented furthermore new bilinear backlund transformation constructed via applying gauge transformation backlund transformation bilinear form
highly pathogenic avian influenza viruses continue nature threaten public health although several viral determinants host factors influence virulence viruses mammals identified detailed molecular mechanism remains poorly defined requires clarification previous studies characterized two naturally isolated viruses similar viral genomes differed substantially mice study explored molecular determinants potential mechanism difference virulence using reverse genetics found single amino acid position protein substantially affected systemic replication pathogenicity influenza viruses mice found mutation introduced linked glycosylation positions protein linked glycosylation enhanced viral productivity infected mammalian cells induced stronger host immune inflammatory responses viral infection findings understanding determinants pathogenicity viruses mammals importance highly pathogenic avian influenza viruses continue evolve nature threaten human health key mutations virus protein viruses viruses potential mammals thorough understanding pathogenic mechanisms viruses help develop effective control strategies however mechanisms virulent determinants influenza viruses fully elucidated study identified glycosylation positions protein two naturally occurring viruses important virulence determinant glycosylation event enhanced viral productivity exacerbated host response thereby contributed high pathogenicity virus mice
paper presents equivalent circuit model absorber based triple hexagonal shaped unit cell absorber possesses nearly wide angle perfect absorption incidence wave polarization independence absorption occurred three different frequencies high ghz ghz ghz respectively equivalent circuit model single hexagonal ring extended triple band absorber structure simulation circuit model full wave simulation regarding return loss absorption important features method simple fabrication absorber maximum absorption three frequencies proposed absorber wide applications thermal detector stealth technology imaging moreover good agreement simulation measurement results observed
background many studies shown migraine patients deficit visual evoked potentials discordant results attributed non blinded analyses lack repeatability aims study compared blinded non blinded analyses recordings assessed test retest repeatability methods recordings healthy volunteers episodic migraine patients analysed two investigators one blinded diagnosis headache phase twelve nine two recordings test repeatability results blinded non blinded analyses normal attack deficient intra individual percentages highly correlated two recordings separated days conclusions studies showing deficit attacks unlikely biased non analysis poor repeatability
research attempts uncover joint planning problem solving roles developing culture supply chain collaboration scc research views collaborative activities internal external focussed functional areas model validated industry data using approach findings show joint problem solving measurement critical developing collaborative culture executing effective planning hence affects core activities collaboration joint planning operation level important culture development research contributes developing collaborative culture making scc effective finally managerial insights future scope highlighted production hosting elsevier ltd behalf indian institute management
article electricity supplementary actuation control system research wind directly driven high pressure pump complemented electricity network supplementary wind great also back coupling electrical network system according amount water successively calculated design select vertical axis wind turbine transmission system system control system final assembly test
novel topology suitable fractional order capacitors using current excitation achieved using fractional order integrator block appropriately configured operational transconductance amplifiers scheme capable fractional order capacitors fractional order without modifications structure implementation allows electronic tuning order capacitance inductance bandwidth operation modification bias current post layout simulation results impedance magnitude phase confirm correct behavior fractional order capacitors two examples highlight applications topology realizing fractional order filter impedance model biological applications examples characteristics circuit validated simulation elsevier ltd rights reserved
silicon bipolar transistor models used technology computer aided design investigate single event transients induced heavy ion pulsed laser two photon absorption sources comparison transient waveforms provided proper extraction heavy ion transients discussed along circuit implications basic laser profiles implemented provide insight future design practices simulation software used describe laser induced terms effective linear energy transfer let
conditional gaussian graphical models multivariate linear regression model explicitly exhibits partial predictors responses partial responses models particularly suitable since partial describe direct relationships variables framework propose regularization scheme enhance learning strategy model driving selection relevant input features prior structural information comes efficient alternating optimization procedure guaranteed converge global minimum top showing competitive performance artificial real datasets method demonstrates capabilities fine interpretation illustrated three high dimensional datasets spectroscopy genetics genomics
background global assessment allows patients assess improvement multiple irritable bowel syndrome ibs symptoms however deemed important assess clinically meaningful improvements focusing patients chief complaint severity major ibs symptoms addition global assessment show effective individual ibs symptoms pilot study explore clinical endpoints focusing chief complaint patients ibs diarrhea ibs methods database used previously reported post marketing phase randomized placebo controlled pilot trial male patients ibs hypothesis completely different study patients ibs diagnosed according rome iii criteria given either placebo daily weeks one week baseline period explore examine endpoints allow evaluation clinically meaningful improvements focusing patients chief complaint chief complaint relief study drug assessed exploratory study results rates patients abdominal pain discomfort stool form stool frequency patients chief complaint administration respectively group placebo group rates improvement symptoms chief complaint patients administration group placebo group last point greatest symptomatic improvement chief complaint group compared placebo group shown respect stool consistency stool form scale scores significantly lower group placebo group last point throughout treatment period except week conclusions acted effectively stool consistency improvement stool consistency considered clinically meaningful endpoint showing effective individual ibs symptoms registered june
dispersive water wave system explored expansion method many new solutions obtained aid method solutions include hyperbolic function solutions trigonometric function solutions rational function solutions new solutions better help understand physical phenomenon dispersive water wave equation
view compatible acting freely responsible opposite view often claimed natural part ordinary social cognition often claimed patterns everyday social judgments reveal implicit commitment either paper reports five experiments designed identify patterns results support nuanced hybrid account central tendencies ordinary social cognition moral responsibility positive moral accountability credit good outcomes neither negative moral accountability bad outcomes choice actions positive outcomes choice actions negative neutral outcomes
session initiation protocol selected official end end signalling protocol establishing multimedia sessions based universal mobile systems network since satellite component identified play integral role need also support based session establishment satellite achieve end end seamless based terrestrial satellite network integration however transport satellite radio interface efficient due request response nature large message size coupled unreliable wireless links larger propagation delay little work carried area paper presents research efficient solutions transport session set signalling radio interface based radio link control acknowledged mode mechanisms two schemes also proposed overcome current procedure applied session set proposed enhancements easy implement fully backward compatible existing implementation units elsevier rights reserved
prospective single arm study participants evaluated extended follow interval determine implementation feasibility safety extended interval veterans stable dose warfarin protocol designed allow rigorous yet pragmatic evaluation week follow interval feasibility determined study enrollment retention participant achievement rates extended interval safety determined bleeding thromboembolism rates participants monitored months despite long term stability participants prior enrollment achieved week follow interval enrolled participants maintained week interval sixteen percent participants never eligible extension follow interval despite meeting initial enrollment criteria two major bleeding events one participant experienced thromboembolic event implementation extended interval follow appears feasible participant enrollment goals met pharmacists able follow study protocol however lower expected proportion participants able achieve maintain extended follow interval future evaluations needed confirm safety extended interval
mutations gene encoding voltage gated sodium channel associated spectrum neurodevelopmental disorders report phenotypes patients review previously reported patients found childhood onset months age occur almost often early onset months thus frequent previously reported distinct phenotypes seen within late onset group including epilepsy two patients emerging west syndrome two patients focal electrical status slow sleep like eeg pattern six patients iii west syndrome constitutes common phenotype major mutation two new four previously reported children known phenotypes include syndrome epilepsy infancy focal seizures intellectual disability autism without epilepsy assess response therapy retrospectively reviewed treatment regimen course epilepsy patients documented medical information available find use sodium channel blockers often associated clinically relevant seizure reduction seizure freedom children early months whereas drugs less effective contrast sodium channel blockers rarely effective later onset months sometimes induced seizure worsening regarding genetic findings mutations exclusively seen patients late onset lack response sodium channel blockers functional characterization four selected missense mutations using whole cell patch cells together data literature suggest mutations associated early epilepsy result increased sodium channel activity gain function characterized slowing fast inactivation acceleration recovery increased persistent sodium current good response sodium channel blockers clinically found associated relatively small gain function contrast mutations patients late onset forms insufficient response sodium channel blockers associated loss function effects including shift voltage dependent activation shift channel availability steady state inactivation clinical experimental data suggest correlation age disease onset response sodium channel blockers functional properties mutations children related epilepsy
noninvasive minimally invasive stimulation now widely investigated treatment primary headache disorders particularly migraine review describe methodological challenges studying occipital stimulation devices explore efficacy safety implantable occipital nerve stimulation primary headache disorders including randomized sham controlled clinical trials chronic migraine treatment also review noninvasive stimulation preventive therapy episodic migraine
present sliding mode based control design link mobile hydraulic bounded modeling uncertainties external disturbances mobile hydraulic systems typically subject strong perturbation conditions design resilient control solutions important challenge furthermore nonlinear phenomena primarily characterized easily excited oscillations input nonlinearity friction dynamics proposed control scheme takes advantage input nonlinearity compensation order overcome problems includes formulation sliding mode control based design two strategies attenuation examined aimed improving controller performance experimental results performed industrial setup including comparison pid controller confirm efficacy proposed methodology
insulin plays crucial physiological role glucose control initiating number signaling events binding activating cell surface receptor insulin mimics therefore become promising agents treating diabetes probe mechanism interaction insulin receptor specifically many insulin peptide sequences discovered found selectively function agonists antagonists structures mechanistic details interactions receptor remain challenging characterize work studied folding properties structure site insulin peptide sequence similarities insulin chain critical hormone binding element receptor known terminal peptide first validated simulation approaches predicting known solution structure insulin chain helix applied study folding peptide data predict helical fold first residues helical motifs insulin chain also propose receptor bound models provide mechanistic explanations competing binding properties site wiley periodicals inc
background fertility treatment guaranteed succeed around patients achieve failed treatment represents loss often triggers intense prolonged reactions increasing awareness need support patients failed treatment however effective interventions effect need support expected increase number people delaying increases therefore number assisted reproduction offer solution objective rationale mixed methods review aims investigating patients failed fertility treatment experience significant psychosocial adjustment difficulties warrant provision psychosocial support developing comprehensive model adjustment unmet goals used assist design theory led psychosocial interventions search methods five databases systematically searched december search terms variations fertility treatment psychosocial adjustment post treatment quantitative studies include group mean comparisons psychosocial adjustment mental health patients failed treatment control group qualitative studies focus experiences psychosocial adjustment failed treatment screening data extraction critical appraisal carried independently authors using predefined protocols two meta analyses performed mental health random effect model primary outcome publication bias checked visual inspection plots test fill method three stage thematic analysis results reported primary qualitative papers implemented descriptive second order themes extracted outcomes nine quantitative individuals countries qualitative individuals countries studies included six quantitative studies reported mental health six meta analyses showed failed group worse mental health controls qualitative review resulted first order themes grouped second order themes individual relational adjustment social adjustment acceptance pursuit new life goals meaning making fertility care perceptions needs data showed individual relational social adjustment tended increase time since treatment individuals care perceptions needs also changed data also suggested individuals engage psychological tasks accepting making meaning situation new life goals adjust better fewer support needs predictions articulated three tasks model adjustment unmet goals wider implications results provide compelling evidence provision psychosocial care directed helping individuals goals three tasks model adjustment unmet goals offers comprehensive guidance therapeutic mechanisms psychosocial care target promote adjustment future research test model prospective cohort studies developing testing interventions based predictions
order develop introduce intelligent systems space field adaptive fuzzy logic controller designed attitude determination control subsystem performance efficiency compared traditional proportional integrative derivative pid controller fuzzy controllers already studied satellite attitude control however performance compared classical pid controllers typically implemented board currently controllers designed implemented order tested board nearby mission due requirements imposed mission orbit significant limitations power available small efficient required order fulfill mission objectives comparison classical pid fuzzy controllers shows fuzzy controller much efficient single less power required achieving better precision general pid shows use type intelligent control systems great advantage conventional control systems currently used satellite attitude control open new possibilities application intelligent controllers field space technologies elsevier ltd rights reserved
purpose goal study develop korean version benefit satisfaction willingness continue questionnaire original version subsequent linguistic validation korean patients overactive bladder undergo active treatment physician methods translation linguistic validation performed january validation process included translation forward translation backward translation cognitive results forward translation process terms benefit willingness benefit taking things account adjusted appropriate expressions korean language used original version backward translation process changes made terms equivalence cognitive session patients asked fill answers within minutes reported translated questions clear easy understand one patient felt questions little bit difficult understand however panel decided change expressions overall level comprehension high translated terms accurate enough convey meaning original version conclusions present study showed successful linguistic validation questionnaire studies needed assess psychometric properties
background hydrolase catalyzes final step tyrosine catabolism cleavage carbon carbon bond yield known sequence functions unknown mechanism carbon carbon hydrolysis reactions essential human metabolism aromatic amino acids deficiency causes fatal metabolic disease hereditary type carbon carbon bond hydrolysis also important microbial metabolism aromatic compounds part global carbon cycle results crystal structure determined rapid automated analysis anomalous diffraction data polypeptide folds residue terminal domain residue terminal domain terminal domain defines unusual beta strand topology novel mixed beta sandwich roll structure structure physiological products also determined structure reveals binding near entrance active site binding coordinated calcium ion located close proximity conclusions represents first structure hydrolase acts specifically carbon carbon bonds also defines new class characterized unique alpha beta fold mechanism involving water catalytic suggested based structural observations sequence conservation mutational analysis group proposed function general base proposed function binding substrate activating stabilizing leaving group hole formed proposed stabilize transition state proton transferred leaving group proposed originate lysine results also reveal molecular basis mutations causing hereditary type
clinically important pharmacokinetic interference occurred new formulation levothyroxine combination affect levothyroxine absorption concurrent treatment osteoporosis hypothyroidism levothyroxine problematic drugs taken separately fasting primary objective assess pharmacokinetic interactions new formulation randomized open label way crossover study conducted healthy adults women subjects times separated days alone alone concurrently samples analyzed plasma serum pharmacokinetic drug drug interaction assessed using confidence intervals cis test reference ratio geometric means area concentration time curve time zero last time point auc maximum concentration max results compared default effect boundaries ratio concurrently alone ratio concurrently alone geometric mean ratios alone auc max demonstrating affect pharmacokinetics geometric mean ratios alone auc max demonstrating treatments tolerated clinically important pharmacokinetic interference formulation affect absorption
present study investigated oxidative stress parameters antioxidant defence status perinatal hypothyroid rat liver heart found content differ significantly three groups liver heart level significantly decreased hypothyroid heart liver compared controls slight significant decrease sod activity observed perinatal hypothyroid liver heart significantly increased activity cat observed liver heart hypothyroid pups activity considerably increased compared controls perinatal hypothyroid heart liver hypothyroid pups also found vitamin levels liver decreased significantly hypothyroidism heart perinatal hypothyroid rats gsh content elevated significantly hypothyroid liver heart total antioxidant capacity higher liver hypothyroid group hypothyroid heart thyroxine replacement repair changes normal conclusion perinatal hypothyroidism modulates oxidative stress status perinatal liver heart
empirical analyses testing impacts orientation remain lacking public sector research despite strong normative expectations public managers foster culture risk taking accountability organizations drawing data nationwide survey local governments research uses structural equation modelling examine relationships organizational integration processes performance energy efficiency conservation block programme study finds positively influences programme performance indirectly enhancing knowledge sharing collaboration performance information use practical theoretical implications discussed
advance investigation terrain using remote sensing techniques important determine electromagnetic properties key constituents branches modeled end apply previously proposed virtual partition method numerical simulations demonstrate possesses desired features high fidelity prediction scattering amplitude function energy conservation theorem thus helpful pursuit better coherent scattering models terrain understanding imagery better characterization scattering mechanisms
last years revolution social networks facebook led daily increasing data heterogeneous sources data models platforms heterogeneous data sources many forms deep web relational databases systems sql database systems data systems semistructured files data usually allocated different machines distributed different data models heterogeneous large scale data integration efforts demonstrate valuable contribution implementing data integration platform provides uniform access heterogeneous data sources different versions data reported data source time furthermore platform able integrate data broad range data devices database management systems also accessible almost types data querying devices ensure globally querying integration platform place earth receiving query result data format paper create resource oriented heterogeneous data integration platform facilitates data integration process implements objectives discussed use resource oriented architecture support uniform access types data querying devices anywhere improve query response time
impedance based model doubly fed induction generator systems including rotor part rotor side converter induction machine grid part grid side converter output filter developed analysis mitigation resonance however high frequency resonance systems due impedance interaction system parallel compensated weak network often overlooked paper thus investigates impedance characteristics systems analysis influences rotor speed variation machine mutual inductance digital control delay evaluated two phenomena revealed series system weak power grid parallel rotor part grid part system impedance modeling system weak grid network series system parallel compensated weak network validated experimental results
aim study explore relation problematic gaming behaviour specific psychological factors gaming motives self awareness problematic gaming behaviour structural factors game among finnish adolescents young adults national survey respondents aged participated study study sample randomly selected population register center multiple regression analysis used means examining links game gaming motives addition pairwise comparisons non problematic gaming behavior group problematic gaming behavior group used means examining differences across game use self awareness particularly associated use group games encompassing role playing progression character development action strategy features findings indicated entertainment achievement social motives associated whole study emphasized specific game playing motives involved problematic use digital game playing
low cost high performance vision sensors conjunction aerial sensing platforms providing new possibilities achieving autonomous visual inspection civil engineering structures large volume images given structure readily collected use visual inspection overcoming spatial temporal limitations associated human based inspection although researchers explored several algorithms techniques inspection recent decades major challenge past implementations lies dealing high volume images small fraction important actual inspection processing irrelevant images generate significant number automated visual inspection techniques used coordination methods localize relevant regions images combined automated visual inspection able meet objectives quality human visual inspection enable technology develop validate novel automated image localization technique extract regions interest images utilizing vision based damage detection techniques portions image contain physical region structure targeted visual denoted targeted region interest tri computed based geometric relationship collected images analysis highly relevant localized images enable efficient reliable visual inspection successfully demonstrate capability technique extract using full scale highway sign structure case connections serve
based extended test technique bilinear method dimensional equation investigated describes fluid propagating considered model incompressible fluid aid symbolic computation introduce two new functions discuss multiple periodic soliton solutions dimensional equation entirely new solutions presented figures corresponding solutions illustrated show abundant physics structures
non uniform section introduced powerful approach enhance design flexibility uniform moreover efficient synthesis technique provided design two design examples presented first example single non uniform section second one cascaded double non uniform section featuring larger group delay swing bandwidth hence higher resolution radio analog signal processing asp
background dsm reactive attachment disorder social engagement disorder rare understudied controversial disorders methods comorbidity children diagnosed compared comorbidity adhd autism determine comorbidity differed two common disorders child psychiatric clinics samples included year olds autism adhd children removed environments mean years mean years studied mothers rated children pediatric behavior scale assessing oppositional behavior conduct problems adhd anxiety depression symptoms results five children without none without children traits conduct disorder children children considerably impaired children autism adhd conclusions findings consistent studies indicating high comorbidity extreme without findings noted dsm elsevier ltd reserved
explore possible correlations among brain lesion location development psychiatric symptoms use drugs population patients brain tumor epilepsy medical records patients various types brain tumor mean age years analysed retrospectively patients grade iii glioma previous history seizures psychiatric disorders excluded psychiatric symptoms occurring initiation therapy considered treatment emergent psychiatric adverse events fulfilled following conditions onset within weeks beginning therapy drug discontinuation absence identified possible concurrent cause possible influence following variables analysed drug dose location features tumor location type eeg abnormalities tumor excision already yet performed initiation radiotherapy occurred treated patients multivariate analysis showed significant association occurrence location tumor frontal lobe odds ratio confidence interval value treatment odds ratio confidence interval value drug unrelated acute psychiatric symptoms observed untreated patients treated patients results present study suggest alternative chosen treat seizures patients brain tumor located frontal lobe minimize possible onset
purpose demonstrate potential simple clinical test muscle strength identify susceptibility muscle strain injury methods single case design used specifically elite level male australian rules football player performed bilateral maximum voluntary contractions muscles weekly basis period weeks preceding right muscle strain injury results minimal asymmetry greater difference evident maximum voluntary contractions first weeks days prior injury right maximum voluntary contraction reduced compared left conclusion measuring asymmetry maximum voluntary contractions muscles useful clinical test identify susceptibility muscle strain injury
paper presents division summation sigma digital control based modular multilevel converter modular multilevel converters applied static synchronous high voltage direct current transmission back back power transfer systems wind solar power generation battery storage systems sigma digital control adopted track current reference balance bus capacitor voltage regulate cell module capacitor voltage adopted sigma digital control accommodate wide filter inductance variation take care source voltage harmonics achieve fast tracking response low distortion output current applications active reactive power injection power factor correction based power balance principle combination offset current current arm determined according charge balance principle sigma digital control bus capacitor voltage balancing cell voltage regulation achieved ensure output current low harmonics limitation factor cell voltage regulation discussed paper configuration introduced first control laws current tracking voltage regulation derived detail simulated experimental results obtained verified analysis discussion
higher education pressure advance singular focus assessment outputs measurements encompass impact influence initiatives across aspects academic research learning teaching leadership paper focuses implications shift leadership higher education demonstrating impact leadership higher education requires taking step beyond measuring skills behaviours achievements individual leaders demonstrating universities evaluate impact actions taken build leadership capacity across institution authors extend outcome empirical research distributed leadership approach enabled evaluated australian higher education analyse effectiveness processes measuring output assessing impact influence practice
protein brain derived neurotrophic factor bdnf plays important role diverse memory processes strongly expressed hippocampus hippocampus key structure involved processing information short term long term memory due putative role bdnf memory consolidation prominent single nucleotide polymorphism snp bdnf gene bdnf investigated context long term memory performance students presented words categories consisting eight words fruits vehicles memory recognition task specifically deese roediger mcdermott paradigm recognition performance analyzed min initial presentation word list subsequently week initial presentation overall individual long term memory performance immediately learning word list performance week later differ basis bdnf snp interaction effect bdnf time recall found carriers variant showed strongest decline hit rate performance time
psychopathic individuals account substantial impulsive violence present principal intervention used decrease harm confinement nevertheless confined psychopathic persons return community recent advances understanding neurobiology psychopathy hold promise new research directions effective treatments article explore recent advances genetics electrophysiology brain imaging brief implications new directions research treatment
understanding discharge capacity channels changes hydraulic properties large essential prediction flash floods however information limited steep mountain channels complex nature lack measured data thus obtained detailed water level surface velocity data large floods steep mountain channel documented complex channel morphology affected water flow large installed water level surface velocity sensors cascade pool downstream research forest research institute university forests japan successfully obtained min interval data major storm total precipitation fell maximum rainfall intensity storm height water surface point cross section ranged surface velocity ranged expected changes flow depth surface velocity velocity profiles complex differed even cascade adjacent pool cross sections dramatic changes flow conditions first occurred cascade discharge increased certain point water foot cascade submerged flow occurred thereafter water level increased remarkably surface velocity velocity profile stayed almost constant cascade cross section downstream pool submerged mean water depth surface velocity increased dramatically velocity profile changed slow flow developed lower portion profile water levels increased slightly rainfall diminished first surface velocity markedly declined velocity profile returned original state pool submerged flow bottom cascade temporally spatially detailed flow measurements effectively document characterize flow conditions large flood steep mountain channel field data confirm long held hypothesis marked changes flow conditions occur steps become submerged elsevier rights reserved
channel major threat information system security commonly found operating systems especially cloud computing environment owing characteristics cloud computing environment resources sharing logic boundaries channels become varied difficult find focusing problems paper presents universal method detecting channel automatically achieve global detection virtual machine event record mechanism gather necessary metadata combining shared resources matrix methodology events association mechanism proposed distinctive algorithm accurately locate analyze malicious channels respect behaviors compared popular statistical test methods focusing single channel method capable recognizing detecting channels real time experimental results show method able detect multilevel channels cloud environment effectively also facilitates implementation deployment practical scenarios without modifying existing system copyright john wiley sons ltd
wind energy characterized fluctuation main intermittent source damage stability electrical network leads imbalance production consumption resolve difficulty integration micro grid based wind farm interconnected electricity grid proposed presents first objective paper two level inverter much used domain main limitations solutions fact voltage output presents high inverter practical solution applications high power thus second aim paper consists using inverter main unit farm based three permanent magnet synchronous generators three generators unity connected bus three controlled obtained power injected electricity grid using inverter inductor resistor filter three generators proposed inverter controlled vector control theoretical study suggested farm simulated using matlab simulink environment obtained simulation results confirm approach robustness
flexibility requirements prospective energy systems increase balance intermittent electricity generation renewable energies one option tackle problem electricity storage demand quantification often relies optimization models thermal renewable dispatch capacity expansion within tools power plant modeling typically based simplified linear programming merit order dispatch mixed integer unit commitment economic dispatch latter able capture economic characteristics large extent start costs allows decision generator units simplified method superior computational effort present assessment storage expansion affected method power plant modeling apply cost minimizing optimization model comparing moreover evaluate influence wind photovoltaic generation shares vary granularity power plant mix within results show storage demand technical restrictions affect operating costs leading flexible thermal power plant dispatch storage expansion higher deviation approaches however becomes less pronounced share renewable generation increases elsevier ltd rights reserved
paper two techniques based learning action dependent heuristic dynamic programming demonstrated demand side management domestic electric water problem modeled dynamic programming problem state space defined temperature output water instantaneous hot water consumption rate estimated grid load according simulation learning reduce cost energy consumed approximately respectively simulation results also indicate techniques minimize energy consumed load peak periods result customers saved annually using learning techniques control tank size operation better cost reduction resulted using state art control technique simulation parameters best authors knowledge first work uses approximate dynamic programming techniques solve load management problem
distributed leadership explored internationally leadership model promote advance excellence learning teaching higher education paper presents assessment effectively distributed leadership enabled five australian institutions implementing collaborative teaching quality development scheme called peer assisted teaching scheme scheme brings together expertise teams academics institutional learning teaching portfolio shared goal enhancing learning teaching quality distributed leadership benchmarking tool used assess schemes effectiveness found scheme highly consistent distributed leadership benchmarks benchmarking tool easily used assessing alignment otherwise teaching learning quality initiatives distributed leadership benchmarks paper interest seeking assess implementations distributed leadership improve teaching quality leadership capacity
therapy proven effective decreasing episodes urgency urinary incontinence improving quality life patients refractory idiopathic neurogenic detrusor overactivity definition reporting urinary tract infections dosing varied across trials demonstrated increased risk developing urinary tract infection injections compared placebo injection occurrence urinary tract infections found persist multiple treatment cycles rates seem decrease subsequent treatments multiple theories exist current literature able elucidate mechanism injections increase risk urinary tract infections
relatively new drug introduced treat overactive bladder syndrome used either part combination drug extensively studied good number phase phase iii trials showing promising outcomes studies show effective tolerated drug adverse effects concern review look trials pharmacokinetics mechanism action side effects documented literature
containing intrinsically retinal ganglion cells class established roles non image forming processes contributions image forming vision include estimation animal models central understanding physiological mechanisms function evidence conservation function across species intrinsically retinal ganglion cells divided five ganglion cell subtypes show morphological functional diversity research humans established signal environmental irradiance central body clock solar day regulating circadian processes sleep addition mediate light reflex making readily accessible behavioral marker activity less known function retinal optic nerve disease emerging research providing insight function diabetes hereditary optic neuropathy briefly review anatomical distributions projections basic physiological mechanisms proposed known functions animals humans without eye disease introduce paradigm differentiating inner outer retinal inputs control pathway retinal disease apply paradigm patients age related degeneration cases patients provide initial evidence function altered dysfunction pronounced advanced disease perspective refined paradigms extended assessment tool measurement inner outer retinal dysfunction
paper means similarity transformations study exact analytical solutions generalized nonlinear schrodinger equation variable coefficients equation appears literature describing evolution coherent light nonlinear medium phenomena high intensity pulse propagation optical fibers restricting coefficients satisfy systems solutions present conditions existence explicit solutions family oscillating periodic soliton type solutions also show existence bright dark type soliton solutions means computer algebra system exemplify dynamics solitary wave center solutions produced approach elsevier inc rights reserved
effect mindfulness false memory susceptibility examined three experiments mindfulness encourages judgment free thoughts feelings predicted participants mindfulness condition especially likely form false memories two experiments participants randomly assigned either mindfulness induction instructed focus attention breathing mind induction instructed think came mind overall number words deese roediger mcdermott paradigm correctly recalled differ conditions however participants mindfulness condition significantly likely report critical items participants control condition third experiment tested recognition used reality monitoring paradigm participants reduced reality monitoring accuracy completing mindfulness induction results demonstrate potential unintended consequence mindfulness memories become less reliable
aimed explore correlations eukaryotic translation initiation factor subunit polymorphisms susceptibility efficacy cervical carcinoma august august patients cervical carcinoma enrolled case group healthy individuals selected control group genotypes detected nested polymerase chain reaction restriction fragment length polymorphism patients received evaluated efficacy compared carriers genotype carriers genotype polymorphism higher risk cervical carcinoma polymorphism associated tumor size differentiation degree federation gynecology obstetrics stage lymph node metastasis overall response rate case group response rate genotype carriers higher compared patients genotypes binary logistic regression analysis showed tumor size stage polymorphism influencing factors efficacy univariate analysis revealed age polymorphism differentiation degree stage prognostic factors cervical carcinoma multivariate analysis showed age years higher stage genotypes polymorphism risk factors related prognosis cervical carcinoma polymorphism connected higher susceptibility cervical carcinoma affect efficacy prognosis cervical carcinoma copyright medical university published elsevier taiwan llc
objective aim investigate association prenatal sex hormone exposure dementia diagnosis background evidence indicates relatively low testosterone levels risk factor men develop alzheimer disease research examined current rather testosterone levels little research addressed testosterone women methods men women diagnosed controls estimated prenatal exposure testosterone estrogen using ratio length second fourth digit analyzed data using men versus women controls versus participants analysis variance results men significantly higher ratios male controls indicating lower levels prenatal testosterone higher levels prenatal estrogen exposure women significantly lower ratios female controls indicating higher levels prenatal testosterone lower levels prenatal estrogen exposure conclusions findings suggest lower levels prenatal testosterone higher levels estrogen exposure risk factor men higher levels prenatal testosterone lower levels prenatal estrogen exposure risk factor women risk related prenatal exposure sex hormone different individuals chromosomal sex
efficacy artificial neural networks ann solve complex problems optimize evaluation processes early disease tomato plants reducing required time resources objective study verify efficiency ann predict area disease progress curve reduce number assessments establish best time evaluate early disease tomato severity disease evaluated one hundred thirty five tomato vegetable bank federal university three experiments area disease progress curve calculated data six evaluations diseases severity several ann types multi layer trained taking account values desired output different numbers assessment combinations early disease severity used input efficient predicting reduced number evaluations six two days pathogen inoculation best evaluate severity early disease genotype environment affects efficiency predicting efficient predicting area early disease progress curve fewer evaluations optimized assessment disease tomato elsevier rights reserved
progress science engineering increasing knowledge cell biology enabled develop functional biomaterials providing appropriate biochemical biophysical cues tissue regeneration applications tissue regeneration particularly important treat chronic wounds people diabetes understanding controlling cellular microenvironment wound tissue important improve wound healing process study review different biochemical growth factors peptides dna rna biophysical guidance pressure electrical stimulation pulsed electromagnetic field cues providing functional matrix diabetic chronic wounds biochemical biophysical signals generally regulate cell matrix interactions cell behavior function inducing tissue regeneration chronic wounds technologies devices already developed used clinic employing biochemical biophysical cues wound healing applications technologies integrated smart biomaterials deliver therapeutic agents wound tissue precise controllable manner review provides useful guidance understanding molecular mechanisms signals healing diabetic chronic wounds designing biomaterials treat
utilizing variation across state abortion restrictions different levels provider availability measure whether women age less careful using contraception less costly terms financial opportunity cost effects abortion restrictions largest significant women aged younger effect restrictions decrease magnitude significance gradually women age percent states women without provider increases difficult obtain women likely use pill larger percentage women provider easily obtained negative effect pill usage results indicate young women forward thinking making contraceptive decisions relative direct indirect restrictions abortion access western social science association published elsevier inc rights reserved
ionic polymer metal composite new smart material sensing capability paper experimental setup characterize sensor developed corresponding sensor model constructed based neural networks similar smart materials intrinsic hysteresis nonlinearity inherent sensors case hysteresis operator introduced transform multi valued mapping hysteresis one one mapping corresponding neural model constructed neural network expanded input space order compensate nonlinearity sensor inverse model also constructed form feedforward compensator sensor finally experimental results presented validate proposed method hysteresis compensation
supporting positive development special needs child especially challenging parents separated increased need collaborative parenting wherein information shared intervention plans implemented effectively article evolving literature parental applied families special needs children offers useful model understanding strengths parenting relationships describe typical unique dynamics occur children suffer developmental physical psychiatric syndromes require specific treatment specialized parenting skills examples restrictive described manifest families implications decision making also discussed key points family court community understand unique demands separated families special needs child given syndrome present severity condition understand required parents terms cooperation collaboration typical developmentally based parenting plans apply family special needs child aware parents handle safety basic welfare issues child understand parents approach including versus restricting parents access information child physical access child understand unique ways subtle manifest families special needs child many timely decisions need made families joint legal decision making across board practical effective
experimental advanced superconducting east device began operation east visualization work paid attention simulating running state inner structure system developed display model east facility diagnostic data based compared system new system named scientific east using client server structure combination technology open source software system computer graphics visualization called visualization toolkit libraries graphical user interface developed improve effect virtual east visualize experimental data used get access information east physical properties addition general system supports wide variety formats visualization result output corresponding format input order improve rendering speed used classic algorithm simplify models stage effect made investigation survey revealed system good effect elsevier rights reserved
ovary syndrome three fold higher risk endometrial cancer insulin resistance pertinent factors pathogenesis conditions aim study investigate endometrial regulatory element binding protein gene expression ovary syndrome endometrial cancer correlate endometrial regulatory element binding protein gene expression serum lipid profiles material methodsa cross sectional study performed university hospital total women ovary syndrome endometrial cancer controls participants group recruited clinical biochemical assessments performed endometrial biopsies obtained participants taqman real time polymerase chain reaction endometrial regulatory element binding protein gene systemic protein expression analyzed resultsthe body mass indices women ovary syndrome controls significantly different women endometrial cancer higher mean body mass index regulatory element binding protein gene expression significantly increased ovary syndrome endometrial cancer compared controls regulatory element binding protein gene expression positively correlated body mass index waist hip ratio ovary syndrome statistically significant similarly statistically insignificant positive correlations found endometrial regulatory element binding protein gene expression body mass index endometrial cancer waist hip ratio regulatory element binding protein gene expression significantly positively correlated triglyceride ovary syndrome endometrial cancer respectively quantitative serum regulatory element binding protein gene correlated endometrial gene expression regulatory element binding protein gene expression significantly increased women ovary syndrome women endometrial cancer compared controls positively correlates serum triglyceride ovary syndrome endometrial cancer
background omega polyunsaturated fatty acids fas several beneficial effects cardiovascular disease risk factors effects risk profile mediated several factors including epigenetic modifications objective investigate using genome wide dna methylation analyses methylation changes following supplementation overweight obese subjects identify specific biological pathways potentially altered supplementation results blood leukocytes genome wide dna methylation profiles overweight obese subjects week supplementation fas compared using software supplementation cpg sites assigned genes differentially methylated corrected vertical bar vertical bar similar using pathway analysis system total pathways significantly following supplementation among pathways related inflammatory immune response lipid metabolism type diabetes cardiovascular signaling changes methylation levels cpg sites within correlated changes plasma triglyceride glucose levels changes ratio total cholesterol hdl cholesterol following supplementation conclusions data provide key differences blood leukocytes dna methylation profiles subjects following supplementation brings new potential insights metabolic pathways underlying effects fas health
cardiovascular diseases leading cause mortality among women several countries early detection subclinical atherosclerosis enable adoption preventive measures avoid cardiovascular events study aimed determine prevalence brazilian asymptomatic postmenopausal women risk score low intermediate groups computed tomography ultrasound scans performed asymptomatic postmenopausal women years age survey coronary artery aortic calcification scan assess carotid media thickness identify carotid plaques mean prevalence increased carotid plaques increased plaques coronary artery calcification aortic calcification respectively normal imaging tests found defined least one abnormal imaging test associated age waist ratio systolic diastolic blood pressure hdl levels ratio logistic regression associated higher age lower levels prevalent brazilian postmenopausal women low intermediate risk groups associated higher age lower levels carotid atherosclerosis common presentation group
summary manuscript describes role low vitamin bone metabolism subjects low vitamin frequent condition seems important testosterone inducing low bone mineral density bmd osteoporosis supplementation vitamin bmd years treatment whereas testosterone alone seems ineffective introduction decreased bone mineral density bmd syndrome frequent traditionally related low testosterone levels however low bmd observed also patients normal levels replacement therapy necessarily increase bone mass patients known vitamin levels supplementation study determine vitamin status bone mass subjects compare efficacy therapy vitamin supplementation bmd methods total non mosaic patients age matched male controls evaluated reproductive hormones bone dual energy ray absorptiometry patients hypogonadism deficiency treated gel evaluated months treatment results levels significantly lower patients respect controls significantly lower lumbar femoral bmd percentage osteopenia osteoporosis subjects deficiency higher respect subjects normal related presence absence low levels subjects treated significant increase lumbar bmd treatment difference found treated group conclusion data highlight low levels seem critical role low levels inducing low bmd subjects furthermore vitamin supplementation seems effective replacement therapy alone increasing bmd
human responses android robots become important topic social scientists due increasing prevalence social service robots everyday life present research work effects lateral head feature nonverbal human behavior experience android robots two experiments influence lateral head user perceptions android robots examined photo three different robots manipulated stimuli included head degrees degrees left tilt degrees degrees right tilt degrees position compared head posture found higher scores attributed human spine identical robots head tilt results perceived warmth attractiveness dominance varied robot head yielded effects implications development marketing android robots discussed published elsevier ltd
automatic control gene expression living cells paramount importance characterize endogenous gene regulatory networks synthetic circuits addition technology used maintain expression synthetic circuit components optimal range order ensure reliable performance present based method automatically control gene expression inducible promoter mammalian cells real time approach based negative feedback control engineering paradigm validated method monoclonal population cells constitutively expressing fluorescent reporter protein downstream minimal promoter seven responsive operator motifs cells also constitutively express protein cells grown standard growth medium able bind promoter causing maximally expressed upon addition culture medium promoter thus preventing expression tested two different model independent control algorithms relay proportional integral force monoclonal population cells express intermediate level equal maximum expression level min control input either rich standard growth medium demonstrated relay controllers regulate gene expression desired level despite oscillations case controller around chosen set point
objective neck pain common rheumatoid arthritis ankylosing spondylitis investigated correlation bone marrow edema magnetic resonance imaging mri association clinical complaints neck pain methods cervical spine short tau inversion recovery mri mri patients patients neck pain obtained clinical laboratory data available scored blinded readers using modification published score including various cervical sites degenerative changes also quantified results patients predominantly women mean age years reactive protein crp pain score detected patients involving region vertebral bodies facet joints processes degenerative changes identified patients also vertebral bodies differences found patients versus without cervical clinical assessments numeric rating scale pain median interquartile range pain score crp patients degenerative changes symptom duration longer patients without conclusion small study patients neck pain found many different cervical sites including facet joints processes however occurrence severity correlate severity neck pain
acceptance intention use mobile learning topic growing interest field education although considerable amount studies investigating mobile learning acceptance little research exists investigates driving factors influence students intention use mobile technologies assessment purposes aim study provide empirical evidence acceptance mobile based assessment assessment delivered mobile devices technologies proposed model mobile based assessment acceptance model based technology acceptance model extends context adding perceived ease use perceived usefulness constructs facilitating conditions social influence mobile device anxiety personal mobile self efficacy perceived trust content cognitive feedback user interface perceived value investigates impact behavioral intention use students european senior level secondary school experienced series mobile based assessments three week period structured equation modeling used analyze quantitative survey data according results explains predicts approximately variance behavioral intention use mobile based assessment study provides better understanding towards developing mobile based assessments support learners enhance learning experience promote learning taking advantage distinguished features mobile devices offer implications discussed within wider context mobile learning acceptance research elsevier ltd rights reserved
recent advances materials engineering enabled photovoltaic cells fabricated solid state organic dyes proteins one type organic cell based natural light harvesting protein found plasma membrane salt exposed sunlight molecule acts simple proton pump hydrogen ions cytoplasmic extracellular side transmembrane ion channel two types cells comprised dry aqueous wet thin films described paper self assembled monolayer oriented membrane patches protein created bio functionalized gold surface using molecular recognition technique dry monolayer covered transparent tin oxide electrode complete dry device contrast aqueous cell created monolayer coated porous substrate assembly two micro reservoirs filled solutions platinum wire probes inserted opposing liquid near porous monolayer dry cell generated photo electric response aqueous produced although generated voltages appear small sufficient power various systems mems microfluidic devices
objective study prospectively compare incidence pin tract infection pediatric fractures managed pin care daily every day weekly hypothesized differences three methods june children fractures randomized postoperative pin care cleaning pin tracts daily group cases cleaning every days group cases cleaning weekly group cases three groups comparable respect age gender affected side body mass index bmi fracture type injury surgery time number intraoperative percutaneous follow time collected data pin retention time union time pin tract infection average follow time group months group months group patient demographics intraoperative variables three groups comparable significant difference three groups found union time pin fixation time children cases pin tract infection grade infections classification occurred around pin grade around found differences three groups regards frequency severity pin tract infections however pain frequent group two groups conclusions three methods effective management pin site infection pediatric fractures however excessive frequent care pin care daily disadvantages childs fear parental anxiety
essential design protocol allow sensor nodes trustworthiness mission critical applications based wireless sensor networks wsns however challenge evaluate trustworthiness without appropriate hardware support hence present hardware based remote protocol tackle problem within wsns design sensor node equipped trusted platform module plays role trusted start formulation remote security complete protocol single multi demonstrated results show new protocol effective efficient secure
people reliably distinguish sex faces across age groups rates accuracy lower infants however likely lack pronounced sexually features develop puberty given previous research shown perceivers categorize adult sex automatically whether extend faces infants sex less tested using semantic priming paradigm infant faces preceded categorization male female names results showed participants categorized sex male names significantly faster following perceptions male versus female infant faces though female faces significantly facilitate processing female names asymmetry interference male female faces supports evidence male default conceptions sex among infants previously found adults individuals therefore process sex automatically absence overt cues post sexually features stereotypical providing additional evidence depth flexibility social categorization
dysfunction brain derived arginine systems involved etiology autism spectrum disorder asd certain regions hypothalamus amygdala hippocampus known contain either neurons terminals play important role regulating complex social behaviors present study designed investigate concomitant changes autistic behaviors circulating levels structure functional connectivity specific brain regions autistic children compared typically developing children aged years results showed children asd significantly increased volume left amygdala left hippocampus significantly decreased volume bilateral hypothalamus compared positively correlated plasma level autistic children negative left amygdala bilateral compared degree negative amygdala gyrus associated higher score clinical autism behavior checklist degree negative left amygdala left gyrus associated lowering circulating concentration boys asd autistic children showed higher left hippocampus right subcortical area compared circulating negatively correlated visual listening response score childhood autism rating scale results strongly suggest changes structure brain regions containing involved etiology autism
open source library computational biology developed cardiac electrophysiology tissue simulation support paper introduce features available performing cardiac electrophysiology action potential simulations using wide range models repository mathematics models described units quantities primary idea model defined one place file model code auto generated run time never manually use annotation identify model variables describing certain biological quantities membrane voltage capacitance etc allow relevant models framework consistent units interact via consistent interfaces approach provides great deal flexibility analysing different models system provides wide choice numerical methods solving ordinary differential equations describe models fixed explicit implicit solvers provided discussed previous work introduce generalized integration techniques made available via symbolic manipulation model equations automatically forms required approaches also integrated solvers gold standard systems developed support symbolic computation matrix yielding increases performance accuracy discuss technical details work compare performance available numerical methods finally discuss generalized functional framework uses domain specific language defining complex experiments basis comparison model behavior
identification allergen epitopes key component proper understanding pathogenesis type allergies understanding cross reactivity development particles recognition field molecular due value competitive peptide libraries also immunogenic carriers allergen integrate epitope discovery technology immunization functions single platform article provides overview allergen identified display technique discuss contribution display peptide libraries determining dominant cell epitopes allergens developing immunotherapy understanding cross reactivity determining ige epitope profiles individual patients improve diagnostics immunotherapy also discuss advantages pitfalls methodology used identify validate
small scale engine simulated according linear theory computed results show small scale heat engine diameter resonance tube important influences working frequency performance engine always neglected large scale system likewise analysis experimental results show order obtain better engine performance diameter resonance tube chosen appropriately according tube dimension input heating power provides effective way heat engine according computation analysis small scale engine built resonance tube length diameter respectively working frequency input heating power maximal peak peak pressure amplitude pressure ratio reached mpa respectively able drive electrical generator
investigated role signaling molecule tgf beta pathway cells pathology syndrome diabetic mice animal model cell specific cre mice accelerated development compared cre mice including increased lymphocyte infiltration glands decreased tear saliva production increased levels autoantibodies weeks age activated memory cells cytokine ifn producing cells increased mice however proportion function regulatory treg cells different mice effector cells mice less sensitive cells suppression treg cells differentiation capability cells similar mice expression increased inducible treg conditions cells mice results demonstrate disruption pathway cells mice increases cell activation resulting upregulation cells indicating cells protective role development mice
paper prove existence regularity solution two dimensional system evolutionary inequalities describes model friction heat flux use time retardation regularization technique combined regularized method recent results theory inequalities elsevier ltd rights reserved
article analyze different teaching learning situations identified primary secondary schools delivering inquiry based computer programming classes specifically work data obtained two years team offered teacher development course teaching computer programming data includes pre post teachers survey participated course learned professional development classrooms computer science advance students attended lessons supported teachers implementation teaching programming observed recorded lessons classroom observations pre post teacher identified different experiences introducing teaching computer programming schools identified four situations along two years situations challenge traditional structure formal
myeloid derived suppressor cells immune suppressive cells hallmarks human cancer inhibit cytotoxic lymphocytes cell functions promote tumor immune escape progression therefore considered key targets cancer immunotherapy recent studies determined key role apoptosis pathways tumor induced homeostasis known plays key role regulation mammalian cell apoptosis study aimed determine efficacy underlying molecular mechanism suppression treatment tumor bearing mice inhibitor acid significantly decreased accumulation vivo using like myeloid cell model determined targets increases total cellular level although like cells functional apoptosis pathways induced death occurs apoptosis independent mechanism treatment resulted increase number vesicles finally concomitant inhibition required significantly decrease induced cell death observations indicate targets activate resulting interrupted autophagy stress death therefore inhibitor potentially effective adjunct therapeutic agent suppression enhance efficacy based cancer immunotherapy
present time virtual simulation become popular subject computer graphics main goal simulation context computer graphics reproducing natural phenomena surrounding true life possible way representing natural phenomena factor increasing reality among many kinds simulations realistic ocean simulation become important arena actually interesting natural object model two third surface earth covered ocean water intrinsic part day day life different models represent ocean surface however due highly dynamic behavior ocean representing visual complexity phenomena using basic simulation models challenge thus ocean water simulation computationally expensive process main aim research proposing ocean wave visualization model taking account different sea states proposed sea scale since yet single approach satisfactory outcome state sea changing time time according wind speed various phenomena dynamic feature important serious computer games simulators use rendering mechanism suggests thesis intended provide efficient accurate method represent high quality visual characteristics runs real time produce highly realistic ocean scenes regardless complexity wave model building mathematical model representing shape ocean surface objective research suitable existing wave models used study thesis trying identify suitable wave model among different kind existing wave models representing selected sea state
paper aims contribute existing studies young womens transition adulthood case turkish womens exclusion labour market issue discussed largely within boundaries traditional gender restrictions keep women employment herein argue gender based control young women perceived reason exclusion labour market used disadvantaged women way avoiding difficult employment situations similarly gender roles imposed men also fulfilled due restrictive labour market conditions furthermore suggest poverty simultaneously base traditional gender structure young women young men forcing young women employment young men unstable working conditions argument based study conducted sample females males aged mixed methodology comprising survey questionnaire followed depth interviews focus group discussions employed study
emergency contraception used unprotected sex protected sex sexual assault reduce risk pregnancy emergency contraceptive methods available united states copper intrauterine device highest efficacy followed ulipristal acetate levonorgestrel containing emergency contraceptive pills method however access effective methods limited although advanced prescription emergency contraceptive pills counseling emergency contraception reproductive aged women recommended women advised contact health care providers taking emergency contraceptive pills discuss possible copper intrauterine device placement follow
gpu widely used various applications require huge computational power paper contribute cryptography high performance computing research community presenting techniques accelerate symmetric block aes cast seed idea maxwell architecture proposed techniques consider various aspects block cipher implementation gpu including placement encryption keys box memory thread block size cipher operating mode parallel granularity data copy cpu gpu proposed new method store encryption keys registers high access speed exchange threads using operation gpu block implemented paper operate mode able achieve high encryption speed aes cast seed idea best knowledge first implementation block exploits advanced feature gpu hand block used number generator operating counter mode speed usually slower compare using operations hence attempt modify idea order achieve faster generation modified idea manage pass statistical test except stringent tests
introduction free text fields injury surveillance databases provide detailed information beyond routinely coded data additional data exposures covariates identified narrative text used conduct case control studies methods illustrate developed text search algorithm identify status use unknown national electronic injury surveillance system narratives sports injuries calculated adjusted odds ratios ors head injury associated use non head injuries representing controls validated ors published estimates ors calculated sports examined factors associated reporting results injury narratives reviewed contained sufficient information use case control study adjusted ors head injuries associated wearing smaller consistent previously published estimates cochrane review ors illustrated protective effect sports less conclusions exploratory analysis illustrates potential utility relatively simple text search algorithms identify additional variables surveillance data limitations study include possible selection bias inability identify individuals multiple injuries similar approach applied study injuries conditions risks protective factors approach serve efficient method extend utility injury surveillance data conduct epidemiological research elsevier ltd rights reserved
background contraception little researched topic saudi context receives attention demographic transition implications population policy population saudi arabia appears homogeneous shows differences across social economic groups important component contraception hypothesized saudi arabia determinant fertility along factors age first marriage womens educational attainment education child deaths womens work force participation place residence type family preference sons level living administrative area residence hypothesis significance due fertility depending upon marital relations female literacy migration study intends capture attention social line building happy families specific objectives study assess associates determinants contraceptive use ascertain importance factors promoting contraceptive use methods contraceptive use unique group ever married women employees university examined aim assessing associates determinants sample women drawn simple random sampling method tested self administered questionnaire analyses primarily means age first marriage age marriage age gap years lived number children association demographic geographic social economic variables determinants results demographic variables age number age first marriage continuing first marriage geographic variable place grown social variables type family type job economic variable income significant associates contraceptive use meanwhile age continuing first marriage age first marriage number children home ownership significant predictors conclusions recommendations manipulation indicators characteristics women facilitate demographic scenario desired kingdom conceptualized population policy middle east fertility society production hosting elsevier
non linear semi active vibration control devices experienced significant development recent years due performance advantages compared passive active approaches pulse switching techniques developed field piezoelectric damping lead effective trade offs performance simplicity required power supply control law method based triggering inverting switch produced voltage displacement however case random excitation false switching local reduce efficiency successful approach overcome limitation based statistical examination vibration signal determine optimum triggering voltage level according approach paper presents modified method first time presents novel circuit structure predict optimum trigger time damping switch circuit structure using compact analog devices embedded vibration energy extraction system proposed circuit calculates statistical parameters displacement sensor signal estimates value threshold results cantilever beam excited different excitation forces harmonic random samples pulse forces presented compared numerical simulations elsevier rights reserved
background adverse effects stress wellness trauma team members established however level stress never quantitatively assessed aim study assess level stress using subjective data objective heart rate variability among attending surgeons junior residents senior residents trauma activation emergency surgery methods prospective study participants eight hour calls level trauma center stress assessed based decrease recorded using body sensors stress defined less baseline collected subjective data stress participant calls three groups compared duration different stress levels trauma activation emergency surgery results total participants evaluated hours included trauma activations emergency surgeries stress level increased trauma activations operations regardless level training significantly lower stress compared trauma activation emergency surgery level stress similar trauma activation emergency surgery correlation objectively measured stress level measured stress using state trait anxiety inventory among surgeons residents conclusions surgeon wellness significant concern study provides empirical evidence trauma acute care surgeons encounter mental strain fail recognize stress management burnout important high intensity field research provide insight finding practitioners risk level evidence epidemiologic study level
efficient computational models retain essential physics associated continuous mathematical models important several applications including acoustic optimization heterogeneous wave propagation models naturally posed domains crucial physical requirement scattered fields satisfy radiation condition infinity describe implement efficient high order coupled computer model acoustic wave propagation region comprising bounded heterogeneous media several obstacles heterogeneous media computer model radiation condition exactly hence readily applicable acoustic problem approach suitable using standard low order approximation radiation condition using parallel computing environments demonstrate high order algorithm extensive numerical experiments computational analysis including model problem several material property parameters efficient computer models validation work lead interesting mathematical numerical analysis problems acoustic system defined heterogeneous media comprising smooth non smooth obstacles elsevier rights reserved
wall sex differences injuries presenting united states emergency rooms strength res benefits resistance training include improved muscle strength sports performance include reduced injuries however studies examined sex differences resistance training related injuries objective investigation evaluate sex differences injuries associated strength training adolescents young adults type sprains strains fractures mechanism accidental location head trunk arm hand leg foot injury hypothesized sex differences type mechanism location strength training injuries consumer product safety commission national electronic injury surveillance system using code subjects ages years included study sampling weights used calculate national estimates sample patients men women weighted chi square analyses used compare differences mechanism type location injury men versus women men significantly sprains strains whereas women demonstrated increased accidental injuries compared men trunk commonly injured body part men women men trunk injuries women whereas women foot leg injuries men findings indicate men suffer type resistance injuries strength training sprains strains compared women especially trunk conversely women susceptible lower extremity injuries resulting accidents resistance training
aim determine specific groups occupational stress factors influence duration temporary work disability related arterial hypertension joint complications morbidities methodology workers exposed group control group arterial hypertension worked one workplace minimum years divided subgroups depending presence joint complications morbidities intensity seven groups occupational stress factors total score occupational stress index average number lost working days year analysed results number lost working days due arterial hypertension joint complications morbidities significantly higher exposed group subgroups exposed group high correlation number lost working days total score specific occupational stress factors associated specific complications high demands chronic myocardial infarction cerebral conflict uncertainty cerebral infarction extrinsic time pressure acute myocardial infarction avoidance symbolic non insulin dependent diabetes conclusion specific groups occupational stress factors influence duration work disability associated certain complications morbidities arterial hypertension
objective determine injury rate athletes participating high school design retrospective report review setting national high school participants high school athletes qualified state national rounds assessment risk factors injury reports documented sports medicine personnel variables evaluated injury density frequency mechanism injury injury location injury type follow request results total injury incidents front exposures resulted composite injury density per rough stock athletes accounted injuries followed demonstrated injury densities per respectively injuries sustained animal sprains strains frequent injury types respectively head shoulder respectively commonly injured body parts incidence density per found injury requiring transport conclusions high school athletes sustain similar injuries professional athletes indicating addressing issues youth level great benefit better provide prevention tools athletes mechanism injury methods reduce buck need inquiry
circadian rhythm disorders represent important component underlying pathology depression one subtypes depression disorders play crucial role seasonal affective disorder sad bright light therapy reported novel promising treatment method sad since data revealing efficacy referred adult patients without comorbid disorders however recent years reports presented confirm usefulness specific subpopulations patients including children adolescents pregnant women present review summarizes applications depression childhood adolescence depression patients suffering eating disorders although body evidence still small recommend use first line treatment depression eating disorders patient subpopulations appears useful alternative adjunctive therapy diseases however specific clinical applications areas need investigation
organizational behaviors employees choosing perform beyond work expectations beneficial success organization little research form prosocial behavior private agencies study first examine relationship two forms organizational commitment affective organizational behaviors staff maximum security private prison results ordinary least squares regression analysis supported predictions affective commitment positive association organizational behaviors commitment negative association possible interventions private organizations undertake encourage affective organizational commitment staff discussed
dynamic computer vision control system incorporating open source software technologies python used automate gravity based line liquid liquid extraction continuous flow system able cope significant organic reaction stream significant volume flow changes aqueous organic phase streams due extraction water soluble solvent elsevier ltd rights reserved
background little known trajectories ptsd symptoms across period women trauma histories specifically met lifetime ptsd diagnoses prior pregnancy present study seeks identify factors influence ptsd symptom load across pregnancy early postpartum study impact postpartum adaptation method current study secondary analysis pregnant women lifetime ptsd diagnosis derived larger community sample interviewed twice across pregnancy weeks weeks postpartum assessing socioeconomic risks mental health past ongoing trauma exposure adaptation postpartum results using trajectory analysis first examined natural course ptsd symptoms based patterns across found four distinct trajectory groups second explored factors demographic historical gestational shape ptsd symptom trajectories examined impact trajectory membership maternal postpartum adaptation found child abuse history demographic risk lifetime ptsd symptom count increased pregnancy onset ptsd risk whereas gestational ptsd symptom trajectory best predicted trauma labor anxiety women greatest ptsd symptom rise pregnancy likely suffer postpartum depression reported greatest bonding impairment infants weeks postpartum conclusions screening modifiable risks interpersonal trauma exposure labor anxiety ptsd symptom load pregnancy appears critical promote maternal wellbeing wiley periodicals
recently interesting variant chaotic image cipher using latin square studied extensively lack corresponding development paper performs newly proposed chaotic image cipher using latin square based confusion diffusion despite claim high security demonstrate cipher broken chosen attack combined chosen attack moreover improvement ideas original algorithm given enhance security
flavonoid required number crucial roles potential development variety agricultural medicinal biotechnological applications number recent advancements made characterizing enzymes responsible synthesis important molecules review considered regard biochemical properties expression patterns levels enzyme activity development structure function relationships presented historical context highlight critical findings particularly regard innovative work come research species plant crystal structures solved past decade either alone complex sugar donor acceptor molecules discussed application results structures inform current structure function work implications goals future tertiary modeling studies considered thorough understanding properties critical step future biotechnological application enzymes areas crop improvement custom design enzymes produce desired compounds nutritional medicinal usage
paper investigates physical layer security peer peer relay network amplify forward protocol secure user users coexist multi antenna information two cooperative phases goal optimize transmit power source weights jointly rate maximization subject minimum signal interference noise ratio constraint user individual total power constraints mathematically optimization problem non linear non convex facilitate efficient resource allocation algorithm design alternative null space scheme adopted simplifying joint optimization eliminating information leakage second cooperative phase relay vector lies null space equivalent channel relay links although null space scheme simplifies design resource allocation algorithm considered problem still non convex obtaining global optimum difficult impossible employing sequential parametric convex approximation method propose iterative algorithm obtain efficient solution non convex problem besides proposed joint design algorithm requires feasible starting point also propose low complexity feasible initial points searching algorithm simulations demonstrate validity proposed strategy
numerous long span bridges built throughout world recent years bridges progressively damaged continuous usage throughout long service life failure local structural components detrimental performance entire bridge furthermore detecting local abnormality early stage difficult paper explores novel damage detection method long span bridges incorporating stress influence lines control charts efficacy method case study suspension bridge damage indices based subsequently proposed applied hypothetical damage scenarios one two critical bridge components subjected severe damage comparison study suggests first order difference change accurate indicator location damage extent different levels damage quantified using incorporating bar control chart results study indicate proposed based method offers promising technique damage detection long span bridges
objective evaluate effectiveness crisis response planning prevention suicide attempts method randomized clinical trial active duty presenting emergency behavioral health participants randomly assigned receive contract safety standard crisis response plan enhanced crisis response plan incidence suicide attempts follow assessed suicide attempt self injury interview inclusion criteria presence suicidal ideation past week lifetime history suicide attempt exclusion criteria presence medical condition informed consent active psychosis mania survival curve analyses used determine efficacy time first suicide attempt longitudinal mixed effects models used determine efficacy severity suicide ideation follow mental health care utilization results baseline month follow participants receiving crisis response plan estimated proportion participants receiving contract safety estimated proportion attempted suicide log rank chi hazard ratio suggesting reduction suicide attempts crisis response planning associated significantly faster decline suicide ideation fewer inpatient hospitalization days differences enhanced standard crisis response plan conditions conclusion crisis response planning effective contract safety preventing suicide attempts resolving suicide ideation reducing inpatient hospitalization among high risk active duty
paper propose technique low observability uses active signal tuning real time control object surface temperature according varying background environment achieved applying proper object surface temperature obtained result minimum difference object background experimental verification using thermoelectric temperature control element shows contrast object background reduced night day time compared tuned original contrast values stealth technology demonstrated paper applied many military systems needed stealth performance suitable temperature control unit developed
research investigated effect guide intake diesel engine run higher viscous enhance cylinder intake airflow characteristics first simulation internal combustion engine base model done guide various lengths developed imposed intake investigate airflow characteristics based simulation results five guide models length constructed tested compression ignition engine run according experimental results engine performance emissions found guide length showed highest number improvements length showed second third highest number improvements respectively therefore research concluded guide successfully improved cylinder air flow characteristics improve mixing higher viscous air resulting better performances engines without
take challenge global distributed companies manufacturing engineering accomplished worldwide collaborative way design development production processes execution nowadays spread world ensure quality standards create spatially distributed entities distance collaboration tools provided allow cooperation even large distances virtual reality thereby offering beneficial capabilities exchange current planning stages identify problems solve paper introduces new approach distance collaboration enables users work joint virtual space nearly working together place therefore two full like systems interconnected using virtual collaboration arena platform paper describes requirements mechanical engineers towards distance collaboration tools technical challenges solved enhanced framework working prototype one application field enhanced spatially distributed collaboration typical use case scenario provided highlight interaction cooperation capabilities offered net
seasonal thermal energy storage solar energy local basis finland even international show utilization level solar energy exceed annual local heat requirement similar climate zones study presents options heat electricity generation based local energy systems utilizing seasonal thermal energy energy needs production district finland explored case area project studied impacts introducing solar thermal energy local energy self emissions heating energy supply excess solar heat summer stored using thermal energy storage tank storage use winter around self heat production achieved scenarios studied addition carbon dioxide emissions reduced around dioxide particulate emissions compared business usual situation elsevier ltd rights reserved
semi active control system based use smart magnetorheological control structural response wind turbine proposed herein innovative approach based implementation use variable properties base restraint able modify real time mechanical properties according instantaneous decision given control logic latter addressed control one structural response parameters smart base restraint thought combination smooth elastic springs large scale adjustable control algorithm latter motion making modulate reactive force needed achieve performance goals design operation system shown reference case study consisting almost wind turbine realized scale model denmark technical university table tests performed action two different types wind loads using two written control highlighting high effectiveness proposed control technique encouraging investigate direction
background shortened telomere length observed variety diseases objective analyze mean telomere length patients major depressive disorder key question whether telomere length varies different groups depressive patients methods obtained blood samples patients major depressive disorder healthy subjects isolated genomic dna measured mean telomere length using telomere restriction fragments southern blotting grouped patients according therapy received including total antidepressant dose results mean telomere length entire patient group significantly shorter control group observed significant difference telomere length among different patient groups patient groups significantly shorter telomeres healthy subjects analysis revealed significant association telomere length illness duration telomere length severity depression determined hamilton score conclusion results provide evidence major depressive disorder associated shortened telomeres however differences applied therapy duration illness severity depression seem influence telomere length depression anxiety wiley liss inc
according schema therapy model maladaptive parenting styles interact childs unique temperament development early maladaptive schemas turn increase ones risk developing pathology however authors examined comprehensive model purpose study assess indirect effect perceived parenting styles depressive symptoms furthermore series moderated mediation analyses conducted examine whether indirect effect varies function temperament total undergraduate students completed measures perceived parenting experiences temperament depressive symptoms results indicated schema domains rejection impaired autonomy mediated relationship perceived parenting styles depressive symptoms moderation indirect effect found two twelve tested models study partial support schema therapy model also offers new way looking interactive nature constructs
english speaking western cultures attitudes towards law documented present study examines utility predictors attitudes online survey data obtained convenience sample australian residents controlling demographic variables study examines utility two theoretical models crime model racial model predicting attitudes three factors crime model significantly predict attitudes study extends current literature identifying significance negative perceptions indigenous predicting attitudes results suggest community perception indigenous significant predictor attitudes addition factors crime model future research using representative sample australian population recommended increase confidence findings interpreted
need water management better supports urban populations facing increasing socio ecological challenges study article based brought together professionals water sector understand believe water sensitive city participants called new institutional arrangements requiring collaboration leadership various levels government community groups individual community members adopt model social analytical framework considering implications research findings perspective model argue proposed arrangements involve along benefits increasing complexity costs important consequences forms water sensitive cities take considerations relating costs complexity take particular importance reduced material appears increasingly possible costs complexity conditions readily ameliorated via pathways increased local responsibility meeting water needs rainwater harvesting argue increased participation water related governance responsibility related infrastructure follow readily measures foster local mandated approaches require increased complexity elsevier ltd rights reserved
diet demonstrated profound influence human metabolism aid prevention several chronic diseases relative diet however systematic studies biochemical changes induced human subjects long term study nmr spectroscopy combination multivariate statistical analysis applied explore variability metabolic urinary profiles healthy populations four groups male female male female differences metabolic profiles examined relation diet gender principal component analysis pca spectral found influential low molecular weight metabolites responsible differences diet groups acetyl glycoprotein citrate oxide glycine whereas differences gender groups metabolites creatinine arginine results pca four groups indicated diet plays greater role influencing metabolite differences gender exploration work shows potential metabolomics applied nutritional physiological studies aid studies
rainwater harvesting roof considered valuable water resources material flow analysis water university campus shows rainwater harvesting roof reduce water supply production save year water treatment cost sensitivity analysis suggests water supply conservation additional rainwater harvesting enough water resources rainwater suitable substituted water due convenience assemble ground storage tank pond store harvested rainwater roof current practice rainwater collected discharged drainage system treated wastewater treatment plant utilisation rainwater harvested reduce wastewater amount treated rainwater harvesting reuse promoted campus order encourage sustainable living water conservation policy
hydraulic circuits transfer remarkable amounts energy desired direction without taking large space implement technology harvesting energy wind appropriately models system required hydraulic wind power technology benefits eliminating expensive variable ratio costly maintenance enabling integration multiple wind turbines single generation unit paper dynamics different hydraulic elements studied nonlinearities taken account pressure dynamics different parts system studied motor load effects considered based considerations novel nonlinear state space representation system introduced results mathematical model experimental data compared verify proposed model comparison demonstrated mathematical model captures major characteristics hydraulic circuit model system behavior different operating conditions
present research examined situational individual difference factors influence majority group observers evaluations responses incident bias study participants learned situation white person applying job need high low cost heard make white person non evaluated less appropriate costs low costs high revealing high cost situation appropriate response bias ambiguous study focused high cost situation show evaluations another persons responses bias depend individual differences observers values observers scored low concern evaluated another persons non appropriate participants scored high concern perceived non less appropriate considering responses bias assessed helps illuminate normative processes affect bias contributing knowledge processes allow biases persist elsevier ltd rights reserved
rise quality video production equipment resulted increased interest video mediated tests foreign language listening comprehension although research tests continued fairly steadily since early studies relied analyses raw scores despite growing prevalence item response theory field language testing whole present study addresses gap comparing data identical counter balanced multiple choice listening test forms employing three text types conversation lecture administered university students english japan data analyzed via many facet modeling compare difficulties audio video formats investigate interactions format text type format level identify specific items biased toward one format finally items displaying differences subjected differential functioning analyses interactions format text type format level observed four items discovered displaying format based differences difficulty two found correspond possible acting anomalies videos author argues work focusing item level interactions test format
paper describes new approach design proportional integral derivative pid controller longitudinal airflow velocity road fire situations work shows clearly use proper model provides valid data model based tuning tunnel controllers demonstrated real tunnel tests design uses simplified mathematical model airflow dynamics based continuity equations describe airflow dynamics one dimension optimizing controller parameters site time consuming problem increases case complex several entrance exit typically occurrences traffic congestion approach based design controller simulations use mathematical model airflow velocity tunnel approach lot work time controller tuning within tunnel tests moreover discover potential problems occur real instances fire tunnel additional advantage approach possibility simulate scenario errors failures devices important reliable control longitudinal airflow velocity although approach focused primarily complex road due complexity significant time savings controller tuning also used simpler usually highway design airflow controller complex compared case road paper also includes case study airflow controller design tunnel complex czech republic largest city tunnel central europe elsevier ltd rights reserved
targeting non native ligand binding sites potential therapeutic applications attractive strategy proteins share common native ligands protein member proteins members ras superfamily ras superfamily members bind native ligands switch proteins respectively physiologically essential autophagy transport endoplasmic reticulum apparatus implicated human cancers neurodegenerative disease cardiomyopathy bacteria caused infectious diseases performed structural analyses protein using unique ensemble clustering methods including multi step principal component analysis non negative matrix factorization independent component analysis better identify representative proteins application single clustering method alone used identified representative structures resolved multiple ligand states map known novel binding sites report least novel binding site involving specific residues explored rational design development probes therapeutic small molecules protein proteins wiley periodicals inc
chronic hepatitis virus hcv infection causes severe liver disease affects million individuals novel directly acting targeting hcv revolutionized treatment however high costs limit access therapy recently several related drugs used humans treat allergies emerged potent hcv cell entry inhibitors insights antiviral modes action increase opportunities drug hepatitis possibly important human viral infections
steroid hormones use half century contraceptive agents now researchers elucidating biochemical mechanisms action non target effects progesterone synthetic critical womens health internationally appear important effects immune functioning diverse systems apart separate field devoted understanding progesterone contexts based research following development parallel hormonal contraception progesterone now administered prevent high risk researchers similarly working determine precise biochemical actions immunological effects progesterone progesterone research areas benefit increased collaboration bringing two bodies literature together progesterone actions various hormone receptors lifelong importance different organ systems researchers much learn molecule combination existing literatures future studies build combined knowledge base
challenging strategy reuse structures laboratory training related automation positioning presented laboratory course meant presented students within digital systems control courses
objectives proposal implementation computational framework quantification structural renal damage acid scans aim work propose implement validate computational framework quantification structural renal damage scans observer independent manner materials methods set pediatric positive scans matched controls using expert guided automatic approaches set image derived quantitative indicators computed based relative size intensity histogram distribution lesion correlation analysis conducted order investigate association indicators clinical data interest scenario including reactive protein crp white cell count reflux fever relative perfusion presence renal sequelae month follow scan results fully automatic lesion detection segmentation system able successfully classify positive negative scans auc sensitivity specificity image computed relative size lesion correlated presence fever crp levels measurement derived distribution histogram lesion obtained significant performance results detection permanent renal damage auc sensitivity specificity conclusions proposal implementation computational framework quantification structural renal damage scans showed promising potential complement visual diagnosis non imaging indicators elsevier slu rights reserved
combination analytic individual group psychotherapy indicated patients suffering borderline personality disorder due lack experience tendency split objects good bad partial objects patient develops negative image one therapist represented good enough work negative relationship practice therapists exchange conflicting feelings owing different order integrate partial objects
background microbial genomes national center biotechnology information represent large collection assemblies several complexities associated data great variation sampling density since human pathogens sampled bacteria less represented different protein families occur annotations different frequencies quality genome annotation varies greatly order extract useful information sophisticated data analysis needs performed multiple levels resolution protein similarity adequate sampling strategy results protein clustering used construct meaningful stable groups similar proteins used analysis functional annotation approach create protein clusters three levels first tight clusters groups closely related genomes species level constructed using combined approach takes account sequence similarity genome context second conservative clusters organized seed global clusters finally global protein clusters built around seed clusters propose filtering strategies allow limiting protein set included global clustering clustering procedure subsequent selection organization seed global clusters provides robust representation high rate compression seed protein clusters extended adding related proteins extended seed clusters include significant part data represent major known cell machinery remaining part coming either non conservative unique rapidly evolving proteins rare genomes resulting low quality annotation group together processing proteins requires significant computational resources results large number clusters conclusion developed filtering strategies allow identify exclude peripheral proteins limiting protein dataset global clustering overall proposed methodology allows relevant data different levels details obtained data redundancy eliminated keeping biologically interesting variations
dissociation involves disruptions usually integrated functions consciousness perception memory identity affect precise neurobiological underpinnings dissociation remain elusive neuroimaging studies disorders characterized high dissociation disorder identity disorder subtype post traumatic stress disorder ptsd provided valuable insight brain alterations possibly underlying dissociation neuroimaging studies borderline personality disorder bpd investigating links altered brain function structure dissociation still relatively rare article provide overview neurobiological models dissociation primarily based research ptsd based background review recent neuroimaging studies associations dissociation altered brain function structure bpd studies discussed context earlier findings regarding methodological differences limitations concerning possible implications future research clinical setting
traditionally assumed requirements specification product requirements engineering high impact software development stages therefore knowledge management used construct requirements specification performed structured manner discover analyze understand data information knowledge chain explicit interested parties possess article results literature review presented seeking answer following questions meaning knowledge requirements engineering approaches proposed manage knowledge requirements engineering efficiency efficacy knowledge management models evidenced requirements engineering thirty six works chosen analysis total found search analysis showed knowledge central significance stage authors yet agree best methods apply knowledge general framework emerged validated approach manage knowledge requirements engineering evaluation marks model efficiency efficacy low consisting mostly personal interpretations elsevier ltd rights reserved
public private implementing payment mechanisms improve coordination reduce cost drug hospital ancillary services cancer patients target unnecessary hospitalization others create incentives prescribing lower cost biologics physician payment methods oncology require balance incentives cost control incentives patient access expensive specialty drugs none initiatives adopt methods concern shifting excessive financial risk onto physicians context rapid pharmaceutical innovation value oncology requires physicians monitor coordinate aspects care educate engage patients adopt cost effective drug treatments however oncology practices united states traditionally based number office visits performed cost plus margins prescription expensive drugs public private now methods payment include monthly care management annual incentives conservative choice among alternative drug regimens methodsthis paper uses case study methods examine oncology payment initiatives medicare nations largest public private health insurance plans supplement traditional fee service payment payment methods designed promote coordination care conservative use health care resources medicare reward oncology practices reduce per patient spending targeting unnecessary patient visits emergency departments hospitals offers monthly practices adhere lower cost drug treatment pathways increases percentage low cost generic high cost biologics removes linkage physician payment spending office drugs condition receiving new initiatives requires participating practices report cases improve performance quality metrics none initiatives payment oncology drugs together payment oncology services concern shifting financial risk onto physicians creating access barriers patients conclusionsthe emerging value based methods oncology payment supplement fee service cost based per month per episode none bundle spending cancer drugs services recognize payment create access barriers patients undermine innovation effective expensive new pharmaceuticals
background limited data available regarding reproducibility breath testing clinical application functional bowel disorders objectives purpose study investigate reproducibility breath hydrogen testing assess symptom response testing methods results analysed patients functional bowel disorder breath tests breath tests completed another test weeks later transit time hydrogen responses qualitatively positive negative quantitatively area curve auc hydrogen compared tests another patients data scores overall abdominal symptoms abdominal pain wind nausea fatigue collected test compared hydrogen responses results correlations found auc linear regression transit time spearmans tests significant proportion lost presence conclusions routine use breath tests functional bowel disorder patients supported due poor reproducibility low predictive value symptom responses
many accidents caused human error including things inadequate keeping ship handling also new equipment developed using information technology technology provide various kinds information safe navigation despite efforts reduction accidents occurred degree expected equipment provides much information information organized users feel complicated rather helpful point view method representation information important quantity information research required representation information make information easily understood allow decisions made correctly paper adopt augmented reality technologies representation information computer graphics technology blends virtual reality real world recently technology widely applied daily lives provide information effectively users therefore propose new concept system based technology review experimental results ship handling simulator open sea test verify efficiency proposed system
heat shock proteins essential cell survival function protein role play kidney health disease varied induction either beneficial detrimental kidney depending specific type cell context review addresses role kidney including development various kidney disease models heat shock transcription factor activated stress renal cells induces elaboration separately regulates immune responses contribute renal injury induced intracellular compartment mostly beneficial kidney stabilizing restoring cell architecture function acting protein intracellular also inhibit apoptosis facilitate cell proliferation preserving renal viability acute injury enhancing progression cystic kidney disease malignancy induced extracellular compartment either circulating located outer cell membranes mainly detrimental enhancing inflammation pathways injury correctly harnessing stress proteins promises opportunity alter course acute chronic kidney disease
propose two stage mixed integer linear stochastic optimization model analyze scheduling electricity production units natural gas supply uncertainty due pipeline congestion natural gas price variability first stage stochastic optimization model represents day ahead scheduling unit commitment stage second stage represents actual real time operations number scenarios use model analyze effect unit commitment dispatch two types natural gas supply conditions first analyze case involving low cost natural gas supply natural gas transmission issues related potential gas pipeline congestion examine case involving higher cost natural gas used solely attain feasibility fast events first case mimics situations iso new england system relatively low cost natural gas supply uncertain cold weather conditions due natural gas transmission bottlenecks second case situations california iso system relatively expensive flexible natural gas fired units need used handle rapid changes net demand early late
objective review literature training clinicians person perception accuracy ability correctly judge patients states traits present importance training skill share evidence skill suggest evidence based recommendations implementing training methods conducted literature review person perception training studies developed implemented clinicians also summarized measures evaluate training efficacy barriers implementation future research directions results training studies exist improve clinicians ability perceive patients emotions pain distress depression varied training approach length training study design ten studies showed training benefited person perception accuracy conclusions medical literature previous meta analysis person perception training across contexts demonstrate training person perception accuracy effective examples effective provide suggestions best practices future efforts area practice implications evidence needed create implement produce differences accuracy also patient care outcomes medical curriculum developers researchers collaborate create effective person perception clinicians published elsevier ireland ltd
depression anxiety multiple sclerosis linked severe course disease higher numbers relapses addition poorer treatment adherence exacerbated immune system dysregulation recent investigations indicate psychotherapeutic interventions stress management mindfulness based interventions improve quality life depression anxiety fatigue patients mindfulness ability slow observe experiences truly improves affect regulation mindfulness acquired training advantage psychotherapeutic interventions effects remain time since mindfulness depends regular abilities learned training objective article review current evidence psychotherapeutic psychosocial interventions including stress management beneficial effects patients published elsevier espana slu rights reserved
previous research established media violence causal risk factor aggressive behavior several theoretical mechanisms identified explain effect present study assessed undergraduate students test possibility individual differences attention problems help explain link violent media aggression attention problems proved distinct construct processes believed mediate aggression aggressive beliefs aggression related trait anger trait hostility attention problems uniquely related media exposure total weekly hours violent content aggression attention problems particularly related impulsive opposed aggression results suggest attention problems play important role violent media effects aggression wiley periodicals inc
background computer delivered cognitive behavioural therapy effective alternative provider delivered treatment depression anxiety high attrition poses significant challenge use peer support feasible approach improving engagement less known acceptability among veterans aims obtain feedback veterans depression anxiety preferences activities veterans administration peer support specialists pss helping veterans use moving forward based protocol developed methods delivering support veterans using programme method four focus groups veterans per group provided feedback used development peer supported engagement intervention help veterans depression anxiety use moving forward content areas included roles pss play supporting use engagement moving forward methods delivering support results preferences pss activity focused practical aspects using moving forward including orientation programme technical support monitoring progress feedback also suggested veterans preferred personal roles pss including emotional support application moving forward real life problems conclusions findings extend literature online patient facing mental health protocols identifying emotional support real life skills application preferred components peer support protocol designed enhance use engagement depression anxiety
paper present research design framed feminist research proposal study impacts male division household responsibilities understanding complexity type research proposal created theoretical framework allows understand aspects take account undertake study male mean men take domestic responsibilities economic crisis change gender roles based caregiver design draws array previous studies demonstrate within home often exceed total amount income
notch mediated binary cell fate decisions cells adopt two different according levels pathway activation dependent non dependent fate cells maintain activity levels time remains largely unknown address question cell lineage gives rise drosophila organs lineage primary precursor cell undergoes sequence oriented asymmetric cell two neural precursor states acquiring neuron identity using combination genetic cell biology strategies show scratch two transcription factors belonging superfamily maintain neural commitment directly blocking transcription target genes propose factors act transcription dna binding sites factors maintain state neural precursor cells buffering ectopic variation level activity since scratch present precursor cells findings fundamental understanding precursor cell fate acquisition systems
advent increasing availability super resolution prompted investigate questions localization clustering hope providing precise relevant data focus problem studying inter interfaces topic growing interest cell biology sought identify mitochondria associated membrane candidate sites dual colour large field super resolution images specialized lipid endoplasmic reticulum close mitochondria using total internal reflection fluorescence structured illumination microscopy optics express achieved three dimensional spatial resolution approximate based experimental simulated data studied spatio temporal resolution affects common descriptors localization apparent overlap scaled inversely spatial resolution expected objects close independently precise metrics used important live cell imaging motility made measurements uncertain rendering statements physiological pharmacologic manipulations affect localization less robust density equivalent choice different subcellular regions interest marked effect amount localization size roi chosen study calls interpreting localization data suggests cell motility choice roi analysed effective spatiotemporal resolution impact result hence systematically stated particularly localization arguments used assess effect drug application cellular signalling pathways
representation choice development search operators crucial aspects efficiency evolutionary algorithms combinatorial problems several researchers proposed representations operators manipulate spanning trees paper proposes new encoding called node depth phylogenetic based encoding represents spanning trees relation nodes depths using relatively simple process proposed operators based methods used tree rearrangement phylogenetic tree reconstruction tree reconstruction operators designed high locality feasibility low time complexity unbiased independent weight therefore good choice data structure applied network design problems elsevier rights reserved
objective chronic periodontitis associated increased systemic inflammation osteoporosis proinflammatory cytokines implicated systemic bone loss also associated periodontitis impact control systemic inflammation scaling root bone mineral density bmd postmenopausal women investigated study method materials sixty eight women included test group received along calcium vitamin supplementation twice day months control group received calcium vitamin twice day months bmd serum high sensitivity reactive protein periodontal parameters recorded baseline months results improvement bmd serum showed statistically significant difference groups months binomial logistic regression analysis revealed test group adjusted times likely exhibit normal bmd months results suggest association control systemic inflammation improved bmd women generalized severe
belongs family common pathogen clinics early study regarding infection mainly utilized pathogen culture diagnosis treatment recent progress molecular biology made progress pathogen diagnosis study thus investigated expression cerebrospinal fluid csf children central nervous infection attempt discuss clinical significance genotyping children enrolled parallel controls fluorescent pcr used screen csf positive results obtained samples values less primary screening amplification segment performed followed sequencing positive fragments genotyping rna detected control patients patients rna expression among samples positive segment samples positive sequencing segments showed homology bank standard viral strain fluorescent pcr detect rna csf central nervous infection children efficiency accuracy combined genotyping sequence improve sensitivity typing
despite considerable interest understanding stress influences memory accuracy errors particularly children methodological limitations made difficult examine effects stress independent effects emotional valence remembered information developmental populations study manipulated stress levels year olds exposed negative neutral positive word lists shortly tested recognition memory words false memory non presented related words adolescents high stress condition accurate low stress condition childrens accuracy differ across stress conditions also among adolescents accuracy errors higher negative positive words children word valence unrelated accuracy finally increases childrens adolescents cortisol responses especially high stress condition related greater accuracy false memories positive emotional words findings suggest stress encoding emotional content remembered information influence memory different ways across development highlighting need greater complexity existing models true false memory formation
paper deals rare earth free permanent magnet traction machine design segment electric vehicle four different permanent magnet synchronous machine topologies different magnets arrangement pole pair number selected high potential presented compared thanks computationally efficient finite element based analysis tool developed found flux focusing machine poles outperforms terms torque speed requirement efficiency power weight ratio influence magnet grade resilience symmetrical short circuit condition selected machine investigated shown machine subject complete low grade hard ceramic adopted thereby fostering research new abundantly available magnet grades key penetration new cost effective electrical machines powertrain market
recent theoretical accounts proposed excitation inhibition imbalance possible mechanistic hypothesis underlying neural behavioral dysfunction across neurodevelopmental disorders particularly autism spectrum disorder asd schizophrenia two disorders share overlap clinical presentation convergence underlying genes neurobiology however also clear points dissociation terms phenotypes affected neural circuitry highlight emerging work clinical neuroscience literature examining neural correlates imbalance across children adults asd adults chronic early course discuss findings diverse neuroimaging studies across distinct modalities conducted electroencephalography proton magnetic resonance spectroscopy functional magnetic resonance imaging including effects observed task rest throughout review discuss points convergence divergence asd literature focus disruptions neural balance also consider findings relation predictions generated theoretical neuroscience particularly computational models predicting imbalance across disorders finally discuss human noninvasive neuroimaging benefit pharmacological challenge studies reveal mechanisms asd collectively attempt light shared divergent neuroimaging effects across disorders goal informing future research examining mechanisms underlying imbalance hypothesis across neurodevelopmental disorders translational efforts vital facilitate development informed treatment strategies across neuropsychiatric conditions
background patient adherence important increasing use oral anticancer drugs recent studies reported different adherence rates based self reporting monitoring medication patients awareness monitored results prescription records provide larger objective dataset adherence investigation report use computer algorithm manual review prescription medical documentation determine rate adherence methods two years prescription records five ambulatory cancer centres reviewed prescription data extracted using custom java based software tool compare predicted actual date difference dates primary adherence measure altered treatment date incident estimated using computer algorithm manual review medical charts results prescriptions associated altered treatment date incident based initial computer algorithm reduced adjusting clinic scheduling processes manual chart review adjust valid reasons delay reasons altered treatment date incident identified prescriptions conclusions adherence rate based data seem high consistent findings based patient self report population analysis prescription data custom computer algorithm identify trends adherence efficiency manual review likely required verify results accuracy using altered prescription dates adherence measure requires studies
hirota bilinear transformation symbolic computation maple class solutions directions space reduced generalised dimensional shallow water wave equation resulting solutions contain six parameters two free due translation invariance equation four satisfy determinant condition guaranteeing rational solutions derived interaction solutions solutions one soliton result shows particular solutions specific values involved parameters soliton furthermore extend method general combination positive quadratic function hyperbolic functions especially interesting wave found interaction solutions pair resonance solitons choosing values parameters dynamic properties solutions interaction solutions solutions one soliton interaction solutions solutions pair resonance solitons shown dynamic graphs
using fly machine potassium phosphate crystals surfaces remain significant impact optical performance analysis frequency presented influence root mean squared gradient discussed frequency analysis crystal surfaces performed using wavelet transform power spectral density methods based classification time frequencies vibration machine tool found main reason surface produced improvements machine design parameters proposed limit effects performance crystal society photo optical instrumentation engineers spie
emerging use self physical motor rehabilitation leads specific requirements real time animation combine properties fields computer graphics present method self real time allows high fidelity representation whole body kinematics using anatomical reproducible bone segment definition method requires little setup time low motion photon latency
immunohistochemistry widely tested low cost rapid ancillary technique available laboratories pathology method generally used diagnostic purposes several studies investigated sensitivity specificity different immunohistochemical anti bodies surrogate test determination predictive biomarkers non small cell lung cancer nsclc particularly epidermal growth factor receptor egfr gene mutations lymphoma kinase gene rearrangements review critical examination works comparing consistency expression conventional molecular techniques identify genetic alterations predictive value nsclc discussed summarizing data sensitivity specificity antibodies consistent time come trust least cost effective screening tool identify patients tumors clinical practice hand mutant specific antibodies egfr demonstrate good specificity fair sensitivity raising employment robust predictive biomarkers brief preliminary experiences antibodies met also included
internal energy animals limited current investment reproduction often decreases survival future reproductive success studies showed activities impair strength immune function insects recent evidence contradictory study tested whether activity affects rate encapsulation response males populations populations stay together superior also number common parasites activity affect immunity males populations populations males gut parasites found significant interaction parasite number activity rate encapsulation results suggest costs reproduction higher infected males affect reproductive investment sexual selection
objective reduces high permeability vascular endothelial cells induced tumor necrosis factor alpha alpha study investigated molecular mechanism behind effect aim understanding action sepsis therapy exploring novel therapeutic strategies sepsis patients methods tnf alpha treated human umbilical vein endothelial cell line employed inflammation model peroxidase permeability assays epithelial method used measure permeability cells used assay expression distribution morphology actin expression key molecules related vascular endothelial permeability cadherin detected assays western blotting quantitative real time polymerase chain reaction results incubation tnf septic serum electrical resistance cells decreased permeability cells increased significantly expression higher cadherin lower compared control group actin formation additional stress fibers cells treatment moderated phenomena assays western showed expression significantly upregulated cells treated tnf alpha however inhibit high expression two proteins treatment tnf alpha compared normal cells overexpression upregulated expression downregulated expression cadherin restored vascular endothelial cells due tnf alpha treatment conclusions inhibited vascular endothelial cells induced tnf alpha inhibitory effect related rock signaling pathway elsevier rights reserved
volumes rainwater harvested site estimated short term storage capacity two methods graphical method analytical method first method considers difference demand supply specified period time second uses random events determine analytically storage capacity required guarantee draft comparison two methods indicates minor differences based volume water harvested applying methods run coefficient surface arid semi arid area estimated new analytical approach long term storage capacity utilized estimate pond capacity site local natural streams apply method necessary estimate overall mean storage capacity soil conservation service method utilized technique confirmed graphical method
purpose current study investigated urea possible imaging biomarker renal function means gradient methods three dimensional balanced steady state mri experiments alongside kidney function parameters quantitative polymerase chain reaction measurements performed two groups rats streptozotocin type diabetic group healthy control group results significant decline urea gradient found weeks untreated diabetes agreement increased urea transport transcription conclusion mri urea monitor changes urea concentration gradients diabetic healthy control rats med international society magnetic resonance medicine
fuel economy parallel hybrid electric vehicle hev suffers due significant energy losses wet automatic transmission limited engine operations overcome limitations novel parallel hev hev proposed previously operational feasibility proven study propose systematic methodology assess feasibility hev efficiently optimize acceleration performance design simultaneously using dynamic models assess feasibility entire design spaces two conditions full acceleration moderate acceleration fuel efficiency instantaneous optimization method used rapidly evaluate full acceleration performance designs poor acceleration considered fuel efficiency feasibility determined violation electric motor constraints assumption efficient engine operations feasible design sets assessment used design optimization dynamic programming applied feasible design space pareto front obtained show tradeoff acceleration performance selected final design found superior comparable parallel hev acceleration performance perspectives
rumination involves excessive dwelling negative aspects problems within dyadic relationship rose research focused tendency within particular relationships interested examining behavior rumination outside context preexisting relationship using experimental manipulation rumination primary goal study experimentally test effects rumination examine associations negative positive participants randomly assigned one three interviewing style conditions style problem solving style style results revealed rumination condition significantly differed distraction problem solving conditions overall negative affect sadness anxiety hostility significant differences among groups positive affect conclusion investigation revealed detrimental effects behavior even
recent analysis suggested three strains isolated different copper mine around world affiliated present detailed investigation genomic features particularly respect metabolic potentials stress tolerance mechanisms comprehensive analysis genomes identified core set essential genes specialized biological functions survival habitats despite differences metabolic pathways strains also showed evidence stress management thereby enabling efficiently respond harsh environments analysis metabolic profiles provided novel insights presence genomic highlighting importance gene loss main mechanism potentially contributes cellular another important evolutionary force especially larger genomes gene acquisition via horizontal gene transfer play crucial role recruitment novel functionalities also successful integration genes acquired donors appears effective way enhancing adaptive capacity cope environmental changes taken together findings study significantly expand spectrum genome reduction shaping evolutionary history strains importance horizontal gene transfer gene loss recognized major driving forces contribute adaptive evolution microbial genomes although relative importance remains elusive findings study suggest highly frequent gene within microorganisms via necessary additional novel functionalities increase capacity adapt changing environments evidence also reveals fascinating phenomenon potential cross kingdom furthermore genome critical force driving evolution microbial genomes taken together study provides insights importance gene loss evolution diversification bacterial genomes
objective describe behaviors knowledge related sexual reproductive health spanish university students association subject area studied biomedical methods descriptive cross sectional observational study conducted students aged years university medicine law simple random stratified sampling without replacement performed self administered anonymous voluntary questionnaire distributed based youth risk health behavior survey assessed behavior knowledge three areas sex contraceptive methods sexually transmitted infections stis results total respondents sexual intercourse mean age years mean sexual partners compared law students fewer medical students sexually active later age sexual initiation fewer sexual partners high regular use contraceptive methods observed significant differences groups although unprotected sex often used emergency contraception total respondents knew vaccine human papillomavirus relationship cancer rates significantly higher conclusions behavior knowledge medical students relation sexual reproductive health differed law students elsevier rights reserved
previous studies racial ethnic variation urinary incontinence suggest population specific studies risk factors needed develop appropriate public health recommendations assessed risk factors among postmenopausal mexican women enrolled mexican teachers cohort conducted cross sectional study among postmenopausal women completed questionnaire cases women reported experiencing menopause self reported potential risk factors included age reproductive variables smoking status adiposity several health conditions estimated multivariate adjusted odds ratios ors confidence intervals cis using multivariable logistic regression among postmenopausal women prevalence odds higher among women children women body mass index bmi age first birth years past current never smoking larger waist hip ratio history asthma high blood pressure diabetes also associated higher odds found trend lower odds older age data suggest information prevention strategies particularly useful mexican postmenopausal women children higher bmi studies longitudinal data addition data severity subtype needed provide specific information risk factors mexican women
article presents realization electronically tunable current mode elliptic low pass filter using passive filters prototype signal flow graph method sfg employed synthesis based current required circuit realization proposed filter circuit electronically tuned khz mhz bias current proposed filter use power supply power consumption bias current proposed filter uses grounded capacitors without external resistors suitable integration total harmonic distortion thd low pass filters less operating frequency range pspice simulation results carried obtained using model parameter confirm presented theory
root single cells develop tip growth process shared pollen tubes fungal however structural plant cell walls impose constraints accomplish tip growth addition plant cell walls composed rich include several groups including proline early post translational modification catalyzed defines subsequent glycosylation sites work genetic analyses prove lesser extent pivotal root hair tip growth second demonstrate vitro preferred specificity substrates rather third promoter protein approaches show functions replace three shown targeted secretory pathway forms finally explore impact deficient proline cell wall architecture taken together results support model correct proline possibly required proper cell wall self assembly hence root hair elongation arabidopsis thaliana
attacks web based applications one serious network security threats present web based attacks complex single detection method unable cope emerging attacks motivated efficiently misuse detection anomaly detection propose hybrid model web log intrusion detection considering web log request contains majority attack features propose method extract feature vectors http request distinguish abnormal behaviors users particularly construct normal access model based request feature vectors using means clustering algorithm test data indicate compared single intrusion detection model hybrid intrusion detection model proposed effectively improve detection rate reduce false alarm rate
modern distributed systems require fast scalable efficient processing huge amounts information traditional insufficient purpose hence new models developed paper present design implementation scalable distributed two layer block based also discuss experimental results comparing performance widely used nosql
widespread use esters agricultural pesticides chemical mechanistic probes enzymology interest reactivity substituted analogues phosphate esters brief account summarize recent developments understanding mechanisms hydrolysis methanol containing sulfur atom bridging non bridging position small number highly efficient catalytic systems containing metal ions iii developed promote degradation various classes esters mechanisms base promoted reactions water methanol metal catalyzed cleavage presented discussion catalytic processes salient features aim review provide reader contemporary physical organic description ester cleavage article part special issue entitled chemistry mechanism elsevier rights reserved
disulfide particular edges attracted considerable attention possible substitute platinum catalysts hydrogen evolution reaction complex nature reaction detailed experimental investigations mostly indirect sample dependent therefore density functional theory calculations employed study properties edge influence thermodynamics hydrogen adsorption onto edge effect computational model one dimensional border symmetry imposed length sulfur saturation edge dimensionality material discussed hydrogen adsorption found depend critically coverage extra sulfur edge bare edge fully sulfur covered edge inactive favorable hydrogen binding towards found edge covered sulfur monomers edge provides hydrogen adsorption free energies positioned around hydrogen coverage close experimental values needed reaction
purpose purpose paper explore non technical overview leaders researchers use communications perspective better assess design use digital health technologies improve healthcare performance encourage research implementation use technologies design methodology approach narrative overview showing examples issues benefits introducing healthcare performance insights communications science brings design use findings communications research revealed many ways people communicate non verbal ways lost degraded digitally mediated forms losses often recognized increase risks patients reduce staff satisfaction yet digital technologies also contribute improving healthcare performance staff designed implemented research limitations implications researchers provided introduction limitations research communications science contribute multidisciplinary research approach evaluating assisting implementation technologies improve healthcare performance practical implications using overview managers able ask questions new affect healthcare take stronger role implementing technologies improve performance originality value new insights use understanding applying new communications science situated communications perspective helps assess new technology complement rather degrade professional relationships safer implementation use technologies devised
key issue fruit export classification sorting acceptable marketing present work image processing technique employed grade three varieties separately reason choosing fruit object study abundant consumption worldwide study parameters extracted area length area blue value green value red value width contrast texture width area width length roughness length adaptive network based fuzzy inference system method utilized estimate orange mass data obtained using image processing three varieties model samples divided two sets one training set one testing set results present study demonstrated coefficient determination best model measured respectively addition results indicated estimation accuracy best model measured respectively result satisfactory application estimate orange mass
objective aim study evaluate relationship aggression among men substance dependence addition wanted control effect variables depression anxiety relationship methods participants consecutively admitted substance dependent inpatients patients assessed scale aggression questionnaire beck depression inventory state trait anxiety inventory results substance dependent inpatients constituted group suffering rates married duration education current age differ groups whereas age onset regular substance use lower group group higher scores aggression depression trait state hierarchical linear regression analysis demonstrated difficulty identifying feelings factor related aggression although chronic anxiety contributed relationship particularly anger hostility dimensions aggression conclusion trait directly related aggression whereas state way coping among chronic anxiety indirectly related cognitive affective components aggression relevance relationships prevention treatment substance deserves interest research
propose classical non classical based factor varieties decomposition operators particular provide new method determining whether formula method defining term system strong normalization also suggests original notion logical gate circuit variables becomes logical gates logical operations implemented substitution concerning formulas present simple algorithm based factor varieties reducing first order classical logic logic achieve completeness result first order classical logic without requiring additional structure
important human pathogen causes chronic associated development disease gastric malignancies oral cavity implicated potential reservoir therefore involved stomach sometimes occur following treatment infection objectives paper determine presence oral cavity examine relationship oral subsequent gastric biopsies saliva samples dental plaques obtained adults dna extracted evaluated presence using polymerase chain reaction southern blotting methods persons frequently positive statistically significant correlation presence gastric biopsies oral cavity results suggest relationship gastric infection presence bacterium oral cavity despite present oral cavity variable distribution saliva dental plaques suggesting existence reservoir species potential association gastric
paper provides analysis electrical circuits described fractional equation type order considered gamma laplace transform fractional derivative used keep dimensionality physical quantities auxiliary parameter sigma introduced characterizing existence fractional components system relationship gamma sigma reported response obtained fractional circuits exhibits characteristic behaviors cap resistor charge voltage systems current voltage systems relationship law laws charge stored capacitor induction reported illustrative examples presented
paper indirect combustion noise generated acceleration entropy perturbations supercritical investigated nonlinear regime low frequency limit quasi static hypothesis work study journal fluid mechanics nonlinear noise generation flows without shock particularly focuses flow regimes based analytical model compact journal sound vibration initially developed excitations linear regime nonlinear perturbations full nonlinear analytical solutions provided absence shock second order analytical expressions shock present analytical evaluation shock displacement inside caused forcing proposed maximum possible avoid discussed accuracy second order model nonlinear contributions generated waves addressed model found accurate generated entropy wave negligible nonlinear contributions nonlinearities visible still limited downstream acoustic wave large inlet numbers analytical developments validated thanks comparisons numerical simulations elsevier ltd rights reserved
hazard assessment chemical contaminants often relies short term partial life cycle tests impact low dose throughout entire life cycle species across multiple generations neglected study aimed identifying individual population level consequences chronic water contamination environmental concentrations three organic populations experimental conditions life history assays spanning full life cycle exposed individuals progeny associated population dynamics modelling evidenced life history traits alterations individuals chronically exposed progeny individuals exposed showed accelerated development progeny individuals exposed showed developmental acceleration associated increase mortality rate development life history changes due pollutants exposure resulted relatively shallow increase asymptotic population growth rate exposure six generations revealed evolution population response across generations leading loss previously identified effects emergence tolerance bacillus study light short long term impact environmentally relevant doses life history traits tolerance raising unprecedented perspectives influence surface water pollution vector control strategies overall approach highlights importance considering entire life cycle organisms necessity assess effects pollutants studies ecological risk assessment finally multi study gives new insight influence surface water pollution processes elsevier ltd rights reserved
patient reported outcomes pros europe developed rheumatoid arthritis impact disease important assess patients quality life interpretation culture dependent evaluate potential utility asian rheumatoid arthritis patients cross sectional study english speaking patients singapore tertiary center validity scored higher score indicating worse status assessed spearmans correlation patient global assessment short form consistency assessed cronbachs alpha test retest reliability intra class correlation coefficient icc days feasibility assessed missing data eighty two patients analyzed median age years disease duration years women chinese although moderately active median score low median patients score strongly correlated moderately outcomes physical mental consistency high cronbachs alpha test retest reliability excellent icc confidence interval feasibility good patients missing data despite considerable floor effects appeared valid practical pro assess impact asia asian patients underestimate impact disease compared european patients
syndrome rare autosomal dominant disorder presenting skeletal ocular skin cardiovascular symptoms significant clinical overlap systemic connective tissue diseases including syndrome syndrome mass phenotype documented cardiovascular manifestations account major cause patient morbidity mortality rendering main target therapeutic intervention past decades gene identification studies linked aforementioned syndromes disease genetic defects proteins related transforming growth factor tgf beta pathway greatly expanding knowledge disease mechanisms providing novel therapeutic targets result focus developing pharmacological treatment strategies shifting hemodynamic stress management tgf beta review discuss insights gained molecular biology related disorders past years wiley periodicals inc
purpose purpose paper identify impact human resource development engineering procurement construction project success human resource competency job performance among paper also investigates impact project factors factors affecting including internal factors external factors project implementation design methodology approach structural equation modeling sem spss software used test nine proposed hypotheses respondents comprised participants involved projects throughout findings results show positively affects influenced influenced positively impacts directly impacts originality value study indicates development competent human resources project implementation plays considerable role findings also give project professionals tool improving increase likelihood
computer aided ray increasingly popular method investigate structure materials continuing improvements technique resulting increasingly larger data sets analysis data sets generally involves executing static workflow multiple samples generally performed manually researchers executing processes requires significant time investment workflow able automate activities user useful work developed automated workflow analysis scanned data sets averaging size comparing automated workflow manual workflow indicates significant amount time spent case user interactions manual method workflows return similar results porosity pore frequency distribution finally implementing automated workflow users save time required manually execute workflow time spent productive tasks lay description technological advances ray scanning techniques resulted larger complex datasets processing datasets time consuming repetitive task datasets similar materials tend similar characteristics better way analyze datasets research investigated using computer programming languages instead researchers automatically perform tasks involved analysis datasets ten scanned samples results highlighted benefits using computers automate analysis process demonstrating nearly time required due researchers interacting analysis programs analysis quantitative data provided automated workflow nearly identical results found researchers research highlights benefits using automated computer processing analysis datasets allow researchers spend efforts elsewhere
biological functions series understood study murine two responsible synthesis series mrna expression genes analyzed distribution products also analyzed murine synthase synthase predicted type membrane proteins amino acids respectively northern blotting synthase gene mainly expressed kidney lung also detected many tissues synthase expressed brain heart kidney liver skin testis analysis mainly expressed proximal revealed expression angiotensin converting enzyme ace spleen detected pre cells peripheral region white pulp suggested expression also expressed alveolar lung hair also detected mainly proximal kidney alveolar lung also detected epithelium testis blood vessels endothelial cells brain central veins liver expression patterns two genes products almost corresponded exception results provide essential information functional studies series
cent parameters second cycle showed best diagnostic performances cent yielded similar diagnostic performances predicting favourable responses cent performed better predicting pathological resistance cent results due breast thickness lesion depth
purpose primary objective use substitution models estimate whether replacing time spent sedentary video games active outdoor play active video games associated changes youths mental health methods representative sample canadian youth grades studied exposure variables average hours day spent playing outcomes consisted negative internalizing mental health indicator emotional problems positive internalizing mental health indicator life satisfaction positive externalizing mental health indicator prosocial behavior substitution models estimated extent replacing time spent equivalent amount time mental health indicators results replacing hour day hour day associated confidence interval reduced probability high emotional problems increased probability high life satisfaction increased probability high prosocial behavior replacing hour day hour day associated increased probability high emotional problems reduced probability high life satisfaction reduced probability high prosocial behavior conclusions replacing associated preferable mental health indicators conversely replacing associated deleterious mental health indicators society adolescent health medicine rights reserved
breast cancer surgery chronic condition treatment consists information advice compression physical exercise skin care manual lymph drainage little known patients experience adapt respond treatment thus purpose study investigate describe womens perceptions treatment breast cancer surgery sixteen women breast cancer related recruited four hospitals two rehabilitation clinics participated study semi structured interviews conducted analysed using method five qualitatively different categories description identified uncertainty guilt shame safety autonomy categories described based two dimensional structure patients role internal external locus control understanding chronic disease burden study provided deeper understanding different ways patients perceive respond treatment present findings enable therapist treatment counselling based patients approach patient role ability take responsibility treatment acceptance chronic disease
paper propose three party multi party quantum key agreement protocols single polarization spatial mode degrees freedom based defined collective operations participants agree secure shared key encoding sub secret keys particles moreover security protocols discussed comprehensively showed presented protocols outside attacks participant attacks efficiency analysis also shows two protocols achieve high efficiency besides protocols feasible since preparation state polarization spatial mode degrees freedom available current quantum techniques
educators periodically encounter need report suspicion child abuse neglect studies show school professionals recognize half children uncertainty reporting policies practices procedures experience difficult report made variety emotions need support many educators often encounter challenges barriers reporting procedures within school settings educators lack support educational institution fail report suspicion child maltreatment article explores child maltreatment reporting practices point view school setting proposes strategies address reporting practices effectively appropriate intervention services required meet needs children suspicion abuse neglect built model shape training policies procedures therefore strategies immediately responsive environments imperative educational setting begin reduce number child cases
protein major mechanism establishing secondary complication diabetes mellitus effective inhibition process prevent progression disorder secondary complications known protein inhibitors aim present study demonstrate differential mechanisms action study whether combinatorial therapy act synergistically lower dosage thereby lower toxicity treatment secondary complications diabetes presence urea inhibited effective reducing protein carbonyl formation studies revealed binding reduces affinity glucose demonstrated increase degrees thermal transition dsc studies reduction degrees proving effectively stabilize protein structure combinatorial treatment prevented alpha helix beta sheet transitions inhibited age related fluorescence formation respectively combination reduce dosage almost twenty times way effective protein inhibition without toxicity published elsevier
background validate short version dementia diagnosis standard version dementia diagnosis clinical diagnosis examine concurrent validity world health organisation disability assessment schedule care needs asian older adult population singapore methods data singapore elderly study nationally representative survey older singapore resident population aged years used validity short version dementia diagnostic criteria derived community screening instrument dementia modified consortium establish registry alzheimers disease word list delayed recall depression screen examined standard version dementia diagnosis clinician diagnosis gold standard concurrent validity tested examining relationships short version dementia diagnosis disability care needs results total respondents completed data short version diagnosis included study majority respondents chinese descent indian descent belonged ethnic group found short version dementia diagnosis showed almost perfect agreement standard version dementia diagnosis kappa auc substantial agreement clinical diagnosis kappa auc weighted prevalence dementia population slightly higher based short version diagnosis standard version diagnosis also found short version dementia significantly associated higher disability beta needed care occasionally much time conclusions study found short version dementia diagnosis excellent validity diagnose dementia asian population singapore research required determine usefulness diagnosis clinical practice institutional settings aid early detection intervention dementia
objective several studies knee osteoarthritis suggest intra articular administration acid products relevant option management patients persistent pain aim study report data efficacy guided injections large population patients hip osteoarthritis repeated least times per year seven years patients methods prospective post marketing cohort study data collected registry values index pain vas nsaids intake global medical patients assessments evaluated every six months baseline end follow seven years later inclusion criteria age years symptomatic hip osteoarthritis least year duration months follow patients received acid injections least every six months using ultrasound guidance ensure accurate placement results patients included study patients categorized age classes gender body mass index bmi groups show statistically significant reduction time points compared baseline values index pain vas nsaids intake global medical patients assessments slight differences subgroups obese years patients conclusions study supports clinical efficacy safety patients affected osteoarthritis first study reporting large cohort patients different categories long follow seven years data confirm proper use ultrasound guided background therapy management hip osteoarthritis
health benefits associated diets rich ascribed multilevel biological activities including anti inflammatory effects present study addresses inhibition mechanism exert health promoting effects inhibitory potential analyzed using soybean human neutrophil determined values comprised wide range front sub level practically effect inhibition values found effective soybean inhibitors strong inhibitory potential also reflected values determined inhibition exhibiting respectively mechanism inhibition experiments carried revealed type considering powerful inhibitory properties relation currently known availability human metabolism vivo prevention inflammatory diseases
microglia play pivotal role innate immunity brain development mature progenitor cells brain establish resident population tissue macrophages postnatal brain exert induce inflammatory response pathogens microglia also act brain homeostasis microenvironment using processes cortical spreading depression slowly propagating min wave rapid near complete depolarization neurons astrocytes followed period electrical suppression distinct population cortical neurons implicated brain migraine aura like events also detected stroke traumatic injury causes considerable perturbation ionic environment brain readily detected microglia although known activate microglia role microglial activation related neurological disorders remains poorly understood article first provide overview microglial development multiple functions microglia review existing data relationship microglia discuss relevance induced microglial activation neurological disease
considering increasing energy demands still challenge find finite resources alternative energy owing wide range applications transparency simple structure low cost dye sensitized solar cells extensively studied one promising new generation silicon based solar cells last decade tremendous research efforts improve efficiency solar energy conversion review overview various strategies lead better performance stability fabricated cell recent challenges associated nanostructured electrodes device layer structure design types dyes performance studied discussed
aim study report frequent psychosocial difficulties patients parkinson disease explore relationship disability quality life qol address predictors patients interviewed using protocol composed questionnaire investigating qol disability comorbidity social support questionnaires scales resilience personality traits empathy physician frequent reported spearmans correlation used address relationship qol disability measures multiple linear regression performed investigate predictors eighty patients enrolled women mean age years frequent related cognitive motor sleeping facing things depressive mood anxiety correlated disability rho qol rho lower qol higher disability early age onset shorter disease duration significant predictors adjusted easy use questionnaire contribute toward describing impact patients life extensively thus helping define tailored interventions copyright wolters kluwer health inc rights reserved
background research area psychosocial factors rehabilitation sports injuries focused risk behaviors relatively studies focused behaviors facilitate rehabilitation objective study understand psychosocial features characterize elite female football players express resilient behaviour rehabilitation first time anterior cruciate ligament acl injury reconstruction methods qualitative method used based individual person interviews video communication players incurred first time acl tear season swedish womens elite football league total players first time acl interviewed post season interviews followed thematic content analysis based eight players identified showing resilient behaviors rehabilitation included final analysis results three core themes representing psychosocial factors help players cope successfully rehabilitation identified constructive communication rich interaction significant others strong belief importance efficacy ones actions iii ability set reasonable goals conclusions findings suggest three core themes psychosocial factors characterize first time acl injured elite female football players showing resilience rehabilitation acl reconstruction suggestions medical teams ways support communication self efficacy goal setting rehabilitation process provided
objectives increased arterial stiffness important determinant risk cardiovascular disease lipid profile impairment especially associated blood vessels thus aim study determine five circulating lipid components high density lipoprotein cholesterol hdl non high density lipoprotein cholesterol non hdl low density lipoprotein cholesterol ldl total cholesterol triglycerides best predictor increased arterial stiffness urban brazilian population methods random sample individuals general population brazil years selected lipid components measured using standard methods pulse wave velocity measured using non invasive automatic device increased arterial stiffness defined pulse wave velocity results men total cholesterol associated risk increased arterial stiffness women hdl non hdl good predictors risk increased arterial stiffness however associations found postmenopausal women hdl non hdl conclusion findings indicate hdl non hdl good predictors risk increased arterial stiffness postmenopausal women urban brazilian population useful tools assessing risk arterial stiffness
adolescents involved juvenile justice system higher rates risky sexual behaviors resulting high rates sexually transmitted infections increased risk human immunodeficiency virus early complicated pregnancy parenting issues comorbid substance abuse association mental health issues history abused children result elevated rates girls lesbian gay bisexual transgender youths represent growing subpopulations special risks increasingly community based alternatives juvenile justice involved obtain medical care community providers need understand risks provide appropriate optimal care
isolation characterization moderately bacterium west coast india described present study produced five different extracellular proteases conditions optimized maximum protease production optimized conditions viz medium containing yeast extract nacl produced protease protease partially purified ion exchange gel filtration chromatography purified preparation contained two proteases apparent molecular masses kda respectively preparation stable different concentrations nacl range exhibited maximal activity temperature degrees nacl max values towards min respectively inhibition proteolytic activity indicated nature proteases exhibited remarkable stability presence salt organic solvents properties enable novel applications non aqueous enzymology additive formulations
work presents rail rail operational amplifier design radiation circuit level using standard layout techniques changing transistor layout instance using layout structures allows design simulation using standard models provided circuit fabricated standard cmos process submitted total dose test campaign using radiation source dose rate reaching final accumulated dose circuit proved radiation tolerant tested accumulated dose design practices used mitigate effects presented discussed detail elsevier ltd rights reserved
many recent applications computer graphics human computer interaction adopted colour cameras depth cameras input devices therefore effective calibration types hardware taking different colour depth inputs required approach removes numerical difficulties using non linear optimization previous methods explicitly resolve camera transformation depth colour cameras matrix hybrid parameters introduced optimization hybrid parameters offer transformation depth parametric space depth camera image colour parametric space colour camera image combining intrinsic parameters depth camera rotation transformation depth camera colour camera rotation transformation intrinsic parameters explicitly calculated hybrid parameters help standard test algorithm synthesized data real world data ground truth depth information captured microsoft experiments show approach provide comparable accuracy calibration state art algorithms taking much less computation time method method due advantage using hybrid parameters
objective aims study clarify state information regarding opioids families kinds experiences opioids patient followed outpatient inpatient participants study part cross sectional nationwide survey families patients cancer namely japan palliative care evaluation study participants study comprised families experienced death family member period january december palliative care units main outcome measures response question much improvement needed information regarding opioids answered improvement necessary answered improvement slightly necessary answered improvement necessary answered improvement extremely necessary regarding anxiety use opioid found respondents indicated opioids safe respondents indicated opioids relatively safe respondents indicated opioids safe respondents indicated opioids safe information obtained opioids found families agreed item like clearly explained drugs medical purposes safe patient develop drug addiction life expectancy reduced conclusion study important families patients cancer explained profound careful information opioid
soil erosion serious environmental threat mediterranean region due contributes degradation agricultural land techniques rainwater harvesting improve soil water storage increase agricultural productivity result effective land usage reservoir effective system harvesting rainwater scientifically evaluated like systems suitability conditions spain determined investigate quantify water storage reservoir adapted improve infiltration harvested rainwater laboratory scale rainfall simulator developed rainfall characteristics including rainfall intensity spatial uniformity size confirm natural rainfall conditions simulated sufficient accuracy simulator auto controlled valve three pressure used spray water corresponding five rainfall intensities ranging year return period uniformity coefficients order assess reservoir method surface slopes three soil devices identical volume used make following forms truncated square triangular truncated cone compared control soil surface depression soil used study results show reservoir able reduce soil erosion surface runoff significantly increase infiltration significant difference control compared control depression reduced surface runoff sediment yield concentration elsevier rights reserved
background regulation adaptive survival mechanism cancer cells chemotherapy three new including two iso potential anti cancer agents however capability compounds increase multidrug resistance regulation cancer cells reported purpose study investigate effects iso regulation colorectal adenocarcinoma cells cells addition mechanisms underlying inductive effect also determined methods inductive effect iso expression transcription level measured real time reverse transcription polymerase chain reaction reactive oxygen species production determined assay protein content involvement mitogen activated protein kinases mapk pathway evaluated western blot analysis results iso able increase amount mrna protein cells presence acetyl cysteine significantly prevented inductive effect iso mrna level moreover mapk inhibitors including mapk inhibitor mapk inhibitor suppressed increase mrna levels cells treated iso respectively findings agreement increase phosphorylated form either upon treatment cells three compounds addition iso increased mrna jun level conclusion iso likely regulation expression transcription level molecular mechanisms involve oxidative stress mediated activation mapk signaling pathway elsevier gmbh rights reserved
predicting final depth dynamically installed key prerequisite reliable calculation capacity paper investigates characteristics dynamically installed normally consolidated clay series tests involving model instrumented mechanical system mems accelerometer enabling full motion response established data used assess performance model based strain rate dependent resistance fluid mechanics drag resistance predictions database formed study literature result calculated depths within measurements interesting aspect consistent across entire database relates strain rate dependence frictional resistance relative bearing resistance predictions reveal strain rate dependency indeed higher frictional resistance although soil strength lower fully strength considered reference strength suggests water along boundary layer soil interface installation
recent exponential growth nanotechnology numerous applications nanotechnology based products resulted water pollution engineered nanoparticles last decades membrane technology emerged one promising reliable techniques water purification therefore obvious candidate remove manufactured nano sized contaminants water nanoparticle properties play crucial role performance effectiveness membrane filtration experimental study investigates role nanoparticle size rejection development dead end stabilized silica nanoparticles work filtration silica nanoparticles smaller membrane pore size similar demonstrates increasing nanoparticle diameter pore development specific resistance filtration formed decreases increasing nanoparticle diameter filtration nanoparticles obtained mixing suspensions various ratios shows increasing fraction smaller nanoparticles results delayed pore filtration occurring later stage specific resistance nanoparticles always found obtained nanoparticle suspensions increasing weight fraction larger nanoparticles results faster development nanoparticle rejection due accelerated pore however highly porous structure filtration originating strong surface charges moderate trans membrane pressure applied smallest nanoparticles rejected low extent even filtration stage increase applied transmembrane pressure filtration suspension resulted faster pore higher specific resistance nevertheless rejection nanoparticles filtration stage improved slightly increasing transmembrane pressure elsevier rights reserved
investigated year outcomes three protocols pelvic floor physical therapy anticholinergic drug women wet active bladder oab hundred sixty four women randomly allocated one four interventions drug therapy bladder training pelvic floor muscle training combined pelvic floor rehabilitation includes behavioral advice active treatment group lasted months women completed year follow women responded questionnaires therefore included study outcome measures number per day number urgency urinary incontinence episodes per week completely dry rate incontinence quality life questionnaire qol years years follow outcome measures improved significantly equally four groups median number episodes week dropped groups respectively dry rates groups respectively qol scores improved significantly four groups suffer wet oab experience degree long term improvement following various pelvic floor physical therapy protocols drug therapy neurourol urodynam wiley periodicals inc
background dehydrogenase deficiency recently reported cause responsive syndrome displaying phenotype includes anemia severe combined immunodeficiency objective describe approach molecular diagnosis evaluation immune dysfunction family deficiency methods methods used exome sequencing analysis variants genes involved metabolic pathway family affected siblings routine laboratory research data analyzed gain depth understanding innate humoral cell mediated immune function acid supplementation results exome data concordant variants siblings genes involved metabolic pathway identified heterozygous mutation exon gene shared mother view highly suggestive phenotype extended bioinformatics structural variants gene manual evaluation exome data sequence depth coverage exons deletion involving exon shared father identified routine laboratory data showed involving subsets poor response vaccines vitro analysis dendritic cell lymphocyte function comparable healthy volunteers treatment acid led immune enabling discontinuation prophylactic therapies conclusions exome sequencing demonstrated deficiency novel cause combined immunodeficiency acid established precision therapy reverse clinical laboratory phenotype primary immunodeficiency american academy allergy asthma immunology
yield potential applications areas filtration recovery metal ions drug release tissue engineering catalysts enzyme carriers wound healing protective cosmetics biosensors medical implants energy storage improvement catalytic efficiency immobilized enzymes via materials engineering demonstrated preparation bioactive produced followed chemical attachment model enzyme hand biological perspective almost human tissues organs deposited kind form structure
computer supported collaborative learning aims improve education combining collaborative learning modern information communication technology opportunity exists develop successful applications due increase popularity social networking online gaming among students chapter present approach promoting computer programming using collaboration computer games show improve students metacognitive skills use games motivates students learning process together enhance qualities successful problem solver low problem solving skill identified main challenge faced novice computer programmers
adolescence crucial period emerging sexual orientation gender identity also body image disturbance disordered eating body image distortion disordered eating important pediatric problems affecting individuals along sexual orientation gender identity spectrum lesbian gay bisexual transgender youth risk eating disorders body dissatisfaction disordered eating gender variant youth associated poorer quality life mental health outcomes pediatricians know problems occur frequently youth evidence newer treatment paradigms involving family support effective individual models care
borderline personality disorder bpd reputation challenging disorder treat due nature illness development evidence based treatments therapists becoming skilled successfully helping cohort patients common factor associated validated treatments bpd active involvement therapists example one treatment therapists expected available patients coaching outside sessions however understanding benefits pitfalls associated therapists accessibility sessions relevant treatment contact article three benefits contact described generalize use skills improve understanding patients needs facilitate alliance article also addresses pitfalls therapists accessible patients benefits pitfalls contact illustrated using case assessing function served patients contact sessions important way determine whether contact productive part treatment recommendations provided avoid detrimental outcomes therapist therapist burnout patient
six randomized controlled trials comparing low diet placebo approaches indicated efficacy patients irritable bowel syndrome ibs studies provided food utilized led education met regarding issues choice placebo number patients studied success duration interventions results uniformly positive diet real world experience low diet confirmed findings randomized studies patients respond difficulty delivering diet issue majority patients find diet easy follow led observational studies suggested durability efficacy even association recommended three studies comparing institution standard dietary guidelines ibs low diet found either similar improved outcomes latter low diet also similar efficacy gut directed another strategy broad benefit ibs currently clinically applicable indices predict response diet conclusion clinical trials observational studies support notion led low diet ready considered first line therapy patients ibs use restrictive diet appropriate
engagement cognitive activity physical activity lifespan counteract brain atrophy later life investigated engagement late adulthood association gray matter volume normal older adults special focus hippocampus forty five cognitively normal older individuals mean age underwent weighted mri self reported assessment whole brain voxel wise multiple regression models carried assess relationships volume adjusted age sex adjustment years education risk factors performed voxel wise analyses projected hippocampal surface views cognitive activity demonstrated independent regional associations adjustment confounders cognitive activity related greater extended brain areas including frontal temporal parietal cortices associated increased prefrontal motor cortices regression maps projected hippocampal surface showed common association within anterior part hippocampus although effect subtle also extended posterior part engagement late adulthood independently related regional volume notably aging vulnerable areas results support idea based interventions suitable promote brain health late adulthood potential synergistic effects need addressed future studies including larger samples
flavonoids represent large class secondary metabolites produced plants compounds known abilities antimicrobial responsible flower attract addition properties also specific bacterial regulators governing expression genes involved root bacterial chi first step degradation pathway ring opening form structural biology enzymology plant documented whereas existence bacterial recently elucidated first determination structure bacterial chi provides detailed structural insights key step flavonoid degradation pathway active site confirmed substrate proposed mechanism reaction verified specific isotope exchange observed nmr experiments supported mutagenesis studies active site flexible varying structure modelled different states catalytic cycle using small angle ray scattering data together structures comparison bacterial chi plant enzyme sativa reveals unrelated folds suggesting enzyme activity evolved different proteins despite lack functional relationship tertiary structure bacterial chi shows similarities like fold dismutase stress related protein
introduction mild cognitive impairment common parkinsons disease even early stages risk developing dementia properly track development progression cognitive impairment reliable measurement tools necessary cognitive assessment currently used global cognitive screening tool recommended diagnostic tool measure mild cognitive impairment context global cognitive function however psychometric properties cognitive assessment assessed context methods data obtained parkinsons progression markers initiative examine psychometric properties cognitive assessment among newly diagnosed parkinsons disease patients using analysis results one item measurement model principle component analysis indicated cognitive assessment distribution items formed logical hierarchy least challenging test items markedly target easy sample also reflected low person separation reliability participants performed items correctly indicating large effect participants obtained raw score range indicating mild cognitive impairment meaningful differential item functioning detected conclusion results suggest context early stage parkinsons disease cognitive assessment measure global cognitive function implications use cognitive assessment early stage parkinsons disease potential improvements assessment discussed published elsevier ltd
background clinical features disease courses primary headache diverse aimed identify distinct clinical patterns methods prospectively screened consecutive first visit patients presented headache medical centre headache clinic june march demographics headache characteristics disease courses prospectively evaluated factors related time presentation clinical patterns identified based frequency daily intermittent clinical course total disease duration months results patients included study intermittent chronic daily patterns identified median disease durations days months chronic daily years intermittent features greater severity single side locked locations attacks per day daily occurrence good treatment response chronic daily associated female predominance longer lasting multiple locations bilateral alternating sides characteristics intermittent included female predominance sporadic less intensity conclusions study demonstrated distinct clinical patterns addition help early recognition disease findings suggest different mechanisms future prospective studies required reveal etiologies different patterns optimal treatment strategies
ischemia injury occurs transient hypoxia due obstruction blood flow ischemia followed subsequent tissues skin ischemia main contributing factor pathophysiology pressure ulcers cascade events leading inflammatory response studied spatial temporal responses different subsets immune cells injury understood existing models using technique skin highly invasive unsuitable studying immune responses injury similar non invasive magnet studies skin less ideal imaging studies protocol describe robust model non invasive developed mouse ear skin aim visualize real time cellular response immune cells via imaging
paper presented experimental study circular square area resting sand bed steel model diameter square width sand relative density used reinforced conditions geogrid layers used responses tests investigated results indicated ultimate bearing capacity increased square comparison circular used depth bearing capacity ratio bcr increased greatly circular comparison square bcr increases increasing number geotextile layers square circular reinforced conditions geogrid layers better effect circular comparison square rate increasing bcr circular higher square
beyond natural biological capacities approach evolution molecular biology behaviour thus required explain combined processes technological performances define spiritual formulas whose sole function cultural operates according intentional social modes defined group immediately become conditions evolution choices motor history thus choose path anatomic distant reflection hands leads development abstract thought relationship anatomy awareness allows infinite variations adaptation nature animals societies europe result external evolution continuous distant dispersed across asia biological imposing moral rules balance biology culture reflected rules sharing food biological life coded social sharing systems take ternary values soon include animal behaviours built integrate societies cultural spaces within natural chaos cognitive mechanisms gives entirely new responsibility able define united disciplines transformed ethical requirements published elsevier masson sas behalf des sciences
aim present study compare effect three different kinds film including low density polyethylene film high density polyethylene film chloride film fresh keeping condition simulated cold fresh shelf temperature humidity temperature around degrees storage environment relative humidity around results show film treatment keep better effect compared experiment compared film film film reduce weight loss maintaining high volume fraction low volume fraction first days storage film film significant difference film days storage film film sensory score significantly lower film respiration intensity ethylene production cell membrane permeability also significantly higher film condition fresh keeping effect best
wood contains large amount air even functional air affect water transport determine plant growth survival usually estimated hydraulic methods prone several describe new method estimating based air flow measurements entire branches calculate amount air flowing branch vacuum applied cut bases branches different water potentials first investigated source air determining whether came inside outside branch second compared embolism curves according air flow hydraulic measurements vessel bearing species test hypothesis air flow related embolism air flow came almost exclusively air inside branch min measurements strongly related embolism propose new embolism measurement method simple effective rapid inexpensive allows several measurements branch thus opening new possibilities studying plant hydraulics
study designed investigate effects two instructional approaches versus conventional learners knowledge acquisition learning transfer electrical circuits content physics participants secondary school years participants divided two groups experimental group constituted three intact classes control group constituted two intact classes experimental group taught using digital learning environment designed model principles control group learned contents conventional method assessed students performance knowledge acquisition transfer perceived cognitive load instructional efficiency results indicated experimental group performed significantly better control group knowledge acquisition test learning transfer test also perceived less cognitive load transfer test learning environment developed model proved instructional efficient conventional method
protein belongs enzymes family plays important role metabolism small molecular organic pollutants study generated transgenic plants using agrobacterium pcr analysis confirmed regenerated plants contained transgene gene plasmid southern blotting revealed presence multiple copies genome transgenic plants fluorescent quantitative pcr revealed exogenous gene expression transgenic plants various levels whereas like expression detected either gus transgenic plants wild types absorption transgenic plants analyzed quantitative gas chromatography transgenic plants high expression showed significant increase absorption capacity environmental compared control gus transgenic wild type plants furthermore plants also presented obvious improved resistance formaldehyde study besides first reveal gene enhances plant resistance formaldehyde also new method reducing pollutants formaldehyde using transgenic plants
background radiographic hallmark ankylosing spondylitis detection acute pivotal early diagnosis although radiographic distinguishing feature seen variety disease entities case presentation present interesting case patient disease patient presented inflammatory back pain treated case demonstrates comorbidity disease possible ankylosing spondylitis also present review literature cases involvement joint conclusions addition review radiographic changes joint classical ankylosing spondylitis common diseases compare contrast features diseases mimic pelvic including disease diffuse idiopathic skeletal infections features pelvic radiographic findings help distinguish among mimics however one also rely heavily extra pelvic radiographic lesions addition clinical presentation various clinician correct diagnosis familiar imaging differences among diseases classic spondylitis findings
recent advances enzymology transcription chromatin regulation led discovery proteins play prominent role cell differentiation maintenance specialized cell functions knowledge post synthetic dna histone modifications information rules guide formation chromatin bound complexes helped delineate gene regulating pathways describe pathways altered various pathological conditions present review focuses emerging area therapeutic interference chromatin function purpose cancer treatment
combined oral contraceptives believed cause many effects desired ones use birth control method ones weight gain present designed research focusing possible link recognition facial expressions emotions study examined women including users non users examine possible effect usage accuracy speed recognition facial expressions emotion control variables included research design used hierarchical regression model statistical analysis proved effect usage recognition facial expressions emotions
citations missing links cited paper corresponding papers main consequence several database errors paper investigates possible relationship citations relevant papers relationship potentially meaningful generally impose styles affect database errors efficient others detecting correcting pre existing errors published reducing risk database errors based extensive sample scientific papers manufacturing engineering field study examines citations scopus databases using recent automated algorithm major results significant differences terms citation rate citation rates vary depending database use elsevier ltd rights reserved
support methyl aspartate receptor hypothesis schizophrenia led increasing focus restoring proper glutamatergic signaling approach treatment devastating disease ability glutamate receptors modulate glutamatergic neurotransmission thus attracted considerable attention development novel antipsychotics consisting eight subtypes classified three groups based sequence homology signal transduction pharmacology receptors provide wide range targets modulate function glutamate release recently modulators receptors developed allow unprecedented selectivity among subtypes just groups facilitating investigation effects subtype specific modulation preclinical animal models positive modulators group receptor efficacy across three symptom domains schizophrenia positive negative cognitive discovery development display unique signal bias suggests efficacy retained avoiding effects earlier compounds interestingly negative modulators appear efficacious positive symptom models disease still early preclinical development selective group receptor agonists reached clinical trials unsuccessful specific receptor targeting still hold great promise genetic studies implicated antipsychotic effects group agonists since entered clinical trials additionally appears play important role cognition confer neuroprotective effects thus promising target alleviate cognitive deficits schizophrenia although group iii receptors attracted less attention agonists appear efficacy across three symptoms domains preclinical models recent discovery comprising explain efficacy selective compounds remains determined taken together compounds targeting receptors specifically subtype selective modulators provide compelling alternative approach fill unmet clinical needs patients schizophrenia
summary elderly patients hip osteoarthritis aged dysplasia parameters decreased angle roof angle head index incidence type increased vertebral body fracture frequent type suggesting involvement osteoporosis onset hip osteoarthritis introduction osteoarthritis associated increased bone formation local site however excessive bone resorption also found occur early stages osteoporosis involved onset elderly patients conducted cross sectional radiographic study patients hip examined association age factors dysplasia angle roof angle head index response determine potential involvement osteoporosis methods study included patients men women undergone total hip arthroplasty diagnosis hip measured parameters dysplasia using preoperative frontal ray images evaluated patient according classification hypertrophic type results patients aged parameters dysplasia decreased incidence type significantly higher older patients vertebral body fractures frequent type types additionally index dysplasia lower type contrast hypertrophic type present relatively younger patients associated increased index dysplasia conclusion elderly patients hip parameters dysplasia decreased incidence type increased patients aged frequency vertebral body fracture high patients type suggesting involvement osteoporosis onset hip
cognitive assessment interview interview based instrument assess cognition considering impact cognitive impairment daily activities aimed explore associations spanish version neuropsychological battery measure psychosocial functioning psychosis sample consisted fifty six first episode psychosis patients non patients assessed neuropsychological battery short disability schedule patients also underwent clinical assessment additionally controls assessed neuropsychological battery normalization purposes results showed scores overall correlated neuropsychological battery non patients patients found fewer significant correlations associations maintained controlling clinical symptoms scores contributed variance scores groups negative symptoms good instrument assess cognition non patients patients less effective capturing cognitive impairments functional consequences probably cognitive deficits yet become evident due illness onset functional disturbances observed due cognitive impairments elsevier rights reserved
numerical analysis hydraulic rod rod performed pressure elevated atmospheric analysis consists coupled fluid mechanics contact mechanics load support analyses takes account fluid transport friction force film thickness distribution contact pressure distribution fluid pressure distribution zone computed behavior moderate high rod speeds results indicate friction force exerted rod significantly reduced rod even slightly increased elsevier ltd rights reserved
paper widespread view electricity generation systems transition towards greater proportion provision increasing need storage facilities however differs studies contrasting private incentives storage operator public bulk storage key factor context market renewable energy largely means wind generation nature wind generation problem high variance intermittent nature explored argued missing money missing market issue providing secure energy supplies also missing informational issue key opportunity new storage participation capacity market setting right
fungal infection affects epidermis subcutaneous tissue caused fungal species turn black staining report case year old male patient rural worker treated without success three decades facial lesions progressed caused severe infection evolved left upper developed surgical treatment performed using skin obtained patients abdomen patient developed good postoperative appearance
explored epidemiology outcomes clostridium infection recurrence among medicare patients nursing home whose originated acute care hospitals conducted retrospective population based matched cohort combining medicare claims minimum data set including hospitalized patients age years transferred hospitalization incident defined icd code others prior days recurrence defined within days last day treatment oral oral days part file icd code cox proportional hazards linear models adjusted age gender race comorbidities examined mortality within days excess hospital days costs patients recurrent compared without among survivors index hospitalization discharged suffered recurrence demographics clinical characteristics baseline similar risk death without median number hospitalizations iqr among iqr among without recurrence adjusted excess hospital days per patient medicare group recurrence although recurrent increase risk death associated far higher risk excess hospital days costs medicare
study presents integrated approach targeting critical source areas control source pollution watersheds sensitive areas high pollution producing areas watersheds areas high hydrological sensitivity potential generating runoff based soil topographic index saturation excess runoff process high pollution producing areas areas high potential generating pollutants areas based simulated pollution loads streams soil water assessment tool integrated approach applied river watershed watershed mixed land uses new results show several land uses result water pollution agricultural land causes sediment nitrogen phosphorus pollution cause sediment phosphorus pollution urban cause nitrogen phosphorus pollution primary agricultural three pollutants urban nitrogen phosphorus sediment phosphorus pollution producing areas classified located pollutants generated areas less likely transported runoff streams integrated approach identifies fine scale useful targeting implementation best management practices water quality improvement applied broadly different watersheds improve economic efficiency controlling source pollution
qualitative case study explored one clients recovery borderline personality disorder trauma problem gambling client attended months integrative treatment followed years study included data points client therapist data identified three phases treatment first alliance formation normalization appeared mechanisms client experienced dependence second working alliance appeared mechanisms client experienced reduced gambling suicidal ideation third external controls increased opportunity appeared mechanisms moving world client experience findings give preliminary support phase based treatment including trauma assessment normalize self feelings work support motivation restraint case management principles support continuity change efforts
purpose study compared effects resistance training instability neuromuscular total training volume outcomes obtained part instability resistance training trial parkinsons disease also used linear multiple regression forward stepwise method identify contribution neuromuscular outcomes previously published improvements timed test unified parkinsons disease rating scale motor subscale score methods thirty nine patients moderate severe parkinsons disease randomly assigned three groups control groups performed resistance exercises twice week group used unstable devices perform resistance exercises following neuromuscular outcomes assessed muscle cross sectional area root mean square mean frequency signal peak torque rate torque development half relaxation time knee maximum voluntary contractions calculated lower limb exercises results pre improved neuromuscular outcomes except half relaxation time knee despite lower effective increasing root mean square values mean frequency rate torque development stepwise regression identified changes mean frequency best predictor improvements timed test medication unified parkinsons disease rating scale motor subscale scores conclusion optimizes neuromuscular adaptations partially explains mobility motor sign improvements patients parkinsons disease
usually transport reactions added genome scale metabolic models based experimental data literature approach allow specific genes transport reactions impairs ability model predict effects gene deletions novel methods systematic genome wide transporter functional annotation integration therefore necessary work automatic system detect classify potential membrane transport proteins given genome integrate related reactions proposed based identification classification genes encode transmembrane proteins transport reactions annotation generation tool identifies metabolites transported transmembrane protein transporter family localization carriers also predicted consequently action confined given membrane integration data provided highly models allowed identification new transport reactions included new release software tool previously developed authors reconstruction processes
proliferation biological psychiatry greatly increased last two decades possibility carry brain research using modern technical methods seemed social influencing factors lose importance development mental diseases however actual fact seem justified necessary overcome separation social factors incorporated conceptual framework development mental diseases simultaneously also takes results current neurobiological research consideration aims review article summarize current state research emphasize perspectives biological principles validity respect social dimensions psychiatry exemplified disorders article presents options approach social psychiatry gives overview currently available literature abundance neurobiological research approaches closely associated topics social cognition social psychiatry biological psychiatry longer considered opposed contrary options emerge synthesis used research clinical practice
purpose review review assess benefit treatment terminal cancer pain refractory opioid treatment complicated neuropathy recent findings randomized controlled trials consistently show lack clinical efficacy treating cancer pain large number open label studies case series show benefit summary methyl aspartate receptor antagonist low dose effective analgesic properties cancer pain usually prescribed adjuvant opioid therapy pain becomes opioid resistant pain symptoms dominate clinical picture literature search revealed four randomized controlled trials examined benefit oral subcutaneous intravenous opioid refractory cancer pain none showed clinically relevant benefit pain reducing opioid consumption suggests absence evidence benefit adjuvant analgesic cancer pain findings contrast benefit observed large number open label studies retrospective case series relate opposite outcomes methodological issues complete picture still insufficient evidence state certainty effective cancer pain
subclinical hypothyroidism common problem pediatric population natural history varies depending etiology whether thyroiditis negatively affects natural course investigated pediatric patients without concomitant diseases predictors levothyroxine medication also evaluated medical records children girls years diagnosed retrospectively reviewed patients classified isolated non autoimmune iso median years follow patients eventually initiated levothyroxine patients showed higher probability requiring levothyroxine medication iso patients underlying independently predicted deterioration thyroid function leading levothyroxine medication hazard ratios hrs iso high titers anti antibodies predicted later medication group hrs normal pediatric showed benign self remitting courses underlying significantly increases risk levothyroxine medication especially high titers
urinary system disorders prevented achieving good body hydration level paper investigated measurement platform set detecting yellow colour urine integration iot principles providing ubiquitous services users citizens propose smart iot based holistic system consists urine colour measurement component fitted based rgb colour theory system implemented using board interacts mobile application bio samples urine gathered volunteers tested using board hand held results showed possible infer analysing blue values rgb colour comparison recommended urine colour chart believe proposed system promotes sustainable healthy lifestyle ubiquitous self test solution raises awareness personal way
many studies determined traits emotional dysregulation negative affect impulsivity strongest predictors borderline personality disorder bpd although empirically supported bpd treatments focused based focus upon changing internal representations self studies simultaneously evaluated contribution object relations relation traits predicting bpd symptoms study sought determine combined effects emotional dysregulation negative affect impulsivity object relations prediction bpd use mediation modeling priori hypothesized relationships among variables one hundred sixty nine psychiatric outpatients undergraduate students evaluated self reported trait object relations measures administered semistructured diagnostic interviews bpd although trait object relations measures correlated bpd symptoms best fitting model one object relations partially mediated relationship negative affect impulsivity bpd symptoms direct effects traits also observed mediation self reported object relational quality effect prediction bpd previously recognized within trait framework thus supporting model based treatments bpd
paper responds increasing need earth observation deals design sun synchronous takes consideration composed one orbital planes based mature design approach sun synchronous novel technique design presented takes second gravitational harmonic consideration order obtain regular cycles observation earth single satellite orbital relationships satisfied firstly illustrated making full analyses characteristics satellite ground track orbital parameters properly calculated make satellites pass different ground track single satellite last single plane multi plane used improve observation ground resolution allow observing region local time solar day several times different local time solar day therefore kind meets requirements remote sensing applications need observe region different visible conditions various case studies calculation technique successfully demonstrated published elsevier ltd rights reserved
interleukin pleiotropic cytokine important role immune regulation exercise metabolism exercise predominantly produced within released working skeletal muscle magnitude release related duration intensity exercise first cytokine appear circulation following initiation exercise undergoes pronounced increase compared cytokine response exercise last decade studies suggested role muscle energy sensor pointing potential role biomarker currently elisa western blot detection technique however require substantial time cost machinery specialist training hand graphene oxide based sensor provide real time low cost yet sensitive protein detection coverage mono layered graphene oxide substrate limited due unwanted adhesion layer thus leading low available surface area high variability electrical conductivity chips low sheet transconductance limits sensitivity sensor work overcome limitation carbon edges using ethanol chemical vapor deposition cvd post treated fabricated liquid gated biosensor detection window presented work yielded highly conductive electrically homogeneous carbon based transducer enable low cost facile real time yet sensitive sensors authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering university
new software system design based model assisted analysis complex sample surveys based compared traditional estimation platforms ensures easier safer usage achieves dramatic reduction user workload calibration variance estimation tasks indeed allows specification calibration models symbolic way using model formulae driven symbolic metadata system automatically generates right values formats auxiliary variables sample level user defining calculating corresponding population moreover handle arbitrary complex estimators provided expressed functions calibration estimators complex estimators defined completely free fashion user needs provide system symbolic expression estimator mathematical function fact able automatically complex estimators estimation variance comes cost user remarkably innovative features leverage particular strong point programming language namely ability process symbolic information
limited research predictors bipolar disorder carried year follow patients discharged single mental health unit following admission treatment acute bipolar episode patients followed year association drug regimen prescription antidepressants discharge associated increased risk odds ratio confidence interval among demographic factors smoking age range years conferred increased risk individually optimized drug treatment regimens equally effective practice clear smoking associated
validity proposed sfg model verified comparing theoretical results originally obtained values also introduced weighted averaging method improve parameters estimation accuracy
non verbal communication incorporating visual audio contextual information important make sense social world individuals social situations often difficulty recognizing non verbal social signals article propose training tool non verbal autism plus uses visual audio modalities nonverbal communication training describe design perform experimental evaluation examine potential tool computer based training non verbal communication skills people social communication difficulties series four experiments investigated effect temporal context ability recognize social signals testing context effect modality presentation social stimulus ability recognize non verbal information correlation autistic traits measured autism spectrum quotient non verbal behavior recognition skills measured effectiveness computer based training improving social skills found context information helpful recognizing non verbal behaviors effect modality different results also showed significant relationship communication socialization scores non verbal communication skills social skills significantly improved computer based training
paper proposed ambient light new type signal sources positioning possibility methods positioning presented paper shown two kinds ambient light used positioning different principles intensity spectrum measurements highly location dependency used positioning traditional approach total irradiance intensity used detect proximity lighting source location solution resolved support knowledge lighting infrastructure positioning work areas traditional techniques able function sensor cost efficient size easily integrated sensors form hybrid positioning system paper concluded discussions possibility applicability challenges outlook new ambient light positioning techniques
background anorexia nervosa characterised severe malnutrition intense fear anxiety around food eating associated anomalies information processing previous studies found neuropeptide oxytocin influence eating behaviour lower neurobiological stress response anxiety among clinical populations alter attentional processing food eating related images methodology thirty adult women twenty nine healthy comparison women took part current study study used double blind placebo controlled crossover design investigate effects single dose intranasal oxytocin standard laboratory challenge salivary cortisol anxiety attentional bias towards food images challenge participants attentional bias assessed using visual probe task results relative placebo intranasal oxytocin reduced salivary cortisol altered anomalies attentional bias towards food images group oxytocin induced reduction attentional avoidance food images correlated oxytocin induced reduction salivary cortisol group challenge intranasal oxytocin significantly alter subjective feelings anxiety intake challenge groups conclusions intranasal oxytocin moderate automated information processing biases reduce neurobiological stress investigation effects repeated administration oxytocin processes eating behaviour subjective anxiety interest authors published elsevier ltd
type diabetes mellitus genetic testing undergoing clinical trials measure efficacy genetic counseling behavior based risk reduction expectations patients bring testing process play important role individual outcomes conducted qualitative exploration anticipated decision making expectations around genetic testing semi structured interviews completed mexican americans non hispanic black americans non hispanic white americans risk transcripts analyzed themes participants accept genetic testing order motivate risk reducing behaviors family members risk participants decline testing avoid emotional distress believed test reveal new risk information non hispanic whites college education declined genetic testing often groups without college education likely testing expectations discordant current science genetic testing common blood tests understanding expectations decision making factors around genetic testing better prepare healthcare professionals patients lead higher efficacy genetic testing counseling
alzheimers disease major cause dementia worldwide potent free radical reported neuroprotective present study designed investigate effect chronic administration streptozotocin induced cognitive impairment male wistar rats cognitive impairment developed single injection bilaterally day orally daily administered days water maze passive avoidance tests used assess cognitive functions baseline days caused cognitive impairment evidenced increased escape latency decreased time spent target water maze test reduced retention latency passive avoidance test caused increase oxidative stress inflammatory cytokines protein expression rock decrease protein expression ameliorated induced cognitive impairment induced increase oxidative stress increased levels pro inflammatory cytokines tnf alpha beta mitigated also prevented induced increased protein expression rock moreover significantly prevented induced increased activity cortex hippocampus decreased expression caused brought towards normal hippocampus results thus show protective induced cognitive impairment oxidative stress cholinergic dysfunction altered protein expressions study thus suggests potential adjuvant treatment alzheimers disease
whereas primary prevention seeks development disease individuals elevated risk prevention seeks development risk factors health behaviors characterized lifestyle factors key interventional targets prevention cardiovascular disease appropriate dietary intake including limiting salt saturated fat consumption reduce risk developing hypertension regular physical activity associated lower blood pressure healthier lipid profiles diet exercise critical maintaining weight conducive cardiovascular health behavioral factors stress management sleep duration portion control meal timing play role weight management offer additional routes intervention smoking cardiovascular risk although lifestyle modification programs instrumental reaching public health goals maintaining cardiovascular health matter solely ideally structural social forces make healthy lifestyles default option
extract stems used green inhibitor inhibition mild steel corrosion solution used qualitative quantitative analysis extract corrosion performance extract evaluated using electrochemical impedance spectroscopy polarization weight loss results showed mixed type inhibitor reduces reactions inhibition efficiency reached adsorption isotherm data recorded different temperatures analyzed selected adsorption isotherm models reveal characteristics inhibition thermodynamic calculations showed inhibition efficiency increases increasing inhibitor concentration decreases increasing temperature adsorption mild steel surface found spontaneous adsorption suggested according isotherm model also scanning electron microscopy sem used investigate surface morphology confirm corrosion results
computational demand exact search procedures exploitation parallel processing reduce execution time many applications however often imposes strict restrictions terms problem size implementation efforts mainly due possibly distinct architectures circumvent limitation new exact search alignment tool based transform index presented contrasting alternatives based unified implementation using allowing exploitation multiple possibly different devices intel gpus furthermore efficiently exploit heterogeneous architectures incorporates several techniques promote performance scalability including multiple buffering work task distribution dynamic load balancing together index partitioning bit encoding sampling compared state art tools attained results showed using single gpu faster mainstream multi cpu based like faster best performing state art gpu implementations namely multiple completely distinct devices considered efficiently scales offered throughput ensuring convenient load balance involved processing several distinct devices
signal flow graph expressed matrix form formula expressed analytical way instead topology form result used control system cad software get system models numerically approach flexible efficient methods available
spreading depression cortical activity propagating silencing neuronal activity resulting spreading depolarization evaluated contributions action potential failure adenosine receptor activation depression evoked spontaneous activity vivo mice compared depression induced effects dependent transmission synaptic potentials pathways recovered rapidly within min demonstrated evoked activity distant projection targets evoked potentials recovered next within similar min spontaneous evoked potentials recovered together similar min duration depression shortened systemic focal administration competitive antagonist depression also shortened focal application exogenous adenosine conversely prolonged non competitive inhibitor concluded initial depolarization block brief adenosine activation part contributes persistent secondary phase cortical spreading depression
strengths difficulties questionnaire designed screen behavioral problems youths based cutoff points favor instruments diagnostic sensitivity present study aimed analyze discriminative validity identify behavioral difficulties prosocial resources school age children compared diagnostic data collected corresponding sections development assessment addition new cutoff points value specificity defined scales exploring diagnostic potential study conducted brazil assessed community convenience sample consisted children aged years psychological psychiatric treatment mothers participants also completed sociodemographic questionnaire descriptive statistics used clinically characterize sample roc curve used assess discriminant validity new cutoff points established maximize instruments specificity new cutoff points enabled significant increase specificity without significant loss sensitivity approaches based measures screening diagnosis yet damage instruments screening capacity following increases observed depressive disorder scale cutoff point generalized anxiety disorder scale cutoff point conduct disorder scale cutoff point disorder scale cutoff point antisocial personality disorder scale cutoff point cutoff point applied prosocial behavior scale exhibited increase specificity use specific cutoff points generated accurate results favored use particularly contexts care require precise faster procedures identification problems
design systems based integration several disciplines mechanical electrical software engineering achieve integrated multidisciplinary design development process systems attracted attention academia industry however solutions fully solve problem proposed now concept multidisciplinary interface represents logical physical relationship integrating components system components environment design systems multidisciplinary work multidisciplinary interface model considered one effective supports aid designers achieving integrated multidisciplinary design development process paper presents multidisciplinary interface model design systems order enable multidisciplinary integration among design team members different disciplines one hand proposed model ensures consistency interface defined designers hand helps designers guarantee different components integrate correctly interface model including three concepts classification data model compatibility rules multidisciplinary interface model implemented case study based measurement system elsevier rights reserved
compute modes metric gauge field perturbations black electrically charged theory gauge gravity correspondence theory dual particular class field theories anomaly thermal charged plasma state subjected constant external magnetic field dual poles two point functions energy momentum axial current operators encode information dissipation transport charges plasma complementary gravity calculation work hydrodynamic description dual field theory presence anomaly constant external find good agreement weak field hydrodynamics extend beyond weak regime intermediate regimes furthermore provide results tested thermodynamics hydrodynamics strong regime find exhibiting level behavior become long lived large anomaly coefficient exceeds critical magnitude transport analyzed beyond hydrodynamic approximation five hydrodynamic modes including magnetic wave
paper presents development central electric assisted vehicle handling control system system designed vehicles configured based electric capability networking electric motor control differential brake actuation system improves performance vehicle handling control dynamic vehicle satisfactory drive comfort actuation torque scheme thus achieved coordinated vehicle control brake traction control active torque compensation powertrain based regular vehicle architecture complexity consistency problems associated torque coordination solved additional cost proposed control technology extends capability brake based vehicle dynamic controls enhancement larger stability margin dynamic handling courses
background many studies investigated impact pediatric cognitive rehabilitation therapy upon intellectual functioning traumatic brain injury however relatively identified efficacious treatment school setting objective purpose present variety strategies useful teacher therapist working students learning disabled traumatic brain injury tbi methods article investigates particular challenges learning result impaired cognition suggests techniques improving memory executive functioning results students learning disabled tbi face social emotional issues impact learning special therapeutic interventions necessary assist setting integrating peers coping emotions conclusions students tbi adapt school based setting provided therapies learned strategies targeted specific needs
study evaluates potential life cycle energy savings buildings use efficient structural roof form simulation based optimization methodology developed comparing energy requirements reinforced concrete structures based conventional flat employing alternative spanning elements required quantities high embodied energy materials like steel cement significantly reduced modeling framework combines structural thermal analyses respective quantification embodied operational energy accounts local conditions influencing material production transport code requirements structural reliability heating cooling demands year life span results clearly show potential non flat structural roof forms reduce life cycle energy consumption maximum savings embodied energy nearly cumulative life cycle energy model implemented early design phases achieving environmentally responsible buildings elsevier rights reserved
relationship migration gender roles received increased attention recent decades literature focused migration relationships internal migration gender roles internal migration widely studied paper analyse internal migration experience argue indigenous women engage internal migration mexico city pose greater challenges traditional gender roles community experience single young women capital reliance female social networks allow obtain social migration experience contrast migration mexico city migration although migration challenges extent existing gender roles women migrate often part couples within gendered social networks
social support important mental health hiv positive women limited information exists specific structure composition hiv positive womens support networks associations network properties mental health outcomes pilot study authors examine whether support network characteristics associated depressive symptoms survey network data collected hiv positive women via web based survey application august data analyzed using multivariate linear regression models sas depressive symptoms positively associated greater number doctors womans network hiv positive network members associated less symptom reporting women reported individuals care family support reported feeling less likely report disclosure stigma work highlighted detailed social network data increase understanding social support identify interventions support mental health hiv positive women significant ongoing need support peers
autoimmune myelofibrosis rare entity steroid responsive bone marrow fibrosis variety autoimmune diseases particularly systemic lupus erythematosus sle rarely occur patients autoimmune markers autoimmune disease primary report cases two young women sle associated sle first patient young woman massive splenomegaly fibrosis marrow biopsy splenomegaly resolved completely within weeks treatment corticosteroids repeat marrow biopsy showed marked regression marrow fibrosis second patient young woman fever fibrosis marrow biopsy steroid therapy resulted rapid clinical improvement resolution review literature revealed total patients sle reported date patients sle young women sle blood found increased bone marrow marrow biopsy steroid therapy results rapid hematological recovery regression marrow fibrosis whether one several hematological complications sle represents unique distinct subset patients sle clear prospective studies longer follow needed better define prevalence clinical spectrum sle
ecological city construction important part construction ecological also main direction future urban development construction management economic social development important significance based ecological paper constructs evaluation system ecological city four aspects urban economic social environmental ecological regional support made combination evaluation construction level ecological city city years combined evaluation method principal component analysis results show advantages disadvantages ecological city put forward series countermeasures suggestions build leading promoter future urban ecological
water reuse systems widely implemented across globe solution water shortage freshwater contamination ongoing controversies regarding high energy cost lack sufficient data support benefits water reuse delaying expansion implementation water reuse systems south korea order clarify ambiguity regarding energy demand provide unbiased comparison water reuse alternatives conventional water supply system energy greenhouse gas emissions operation phases different water reuse facilities conventional water supply system examined average total energy consumption greenhouse gas emission conventional process calculated kwh respectively centralized wastewater reuse systems high energy kwh greenhouse gas emissions decentralized wastewater reuse systems reuse rainwater harvesting systems used non potable purposes comparable higher energy demands conventional process kwh adjustment although estimated greenhouse gas emissions processes lower conventional process adjustment considering hidden environmental benefit kwh reduction contaminant release energy demand reuse drops far conventional system suggesting decentralized water reuse key energy efficient water management minimal impact climate change elsevier ltd rights reserved
improve frequency stability interconnected power system including renewable energy sources control actions need robust efficient reason study proposes new optimised proportional integral derivative pid controller coordinated redox flow batteries enhancement load frequency control power system concerning large penetration wind power generation pid controller parameters obtained using recently developed meta heuristic optimisation algorithm named grey show effectiveness proposed control strategy interconnected two area japan east bus machine power system investigated simulation system dynamic responses obtained considering load change area large wind farm integration area comparative study performance proposed strategy known optimisation techniques performed furthermore sensitivity analysis proposed controller also examined varying penetration range integrated wind farm dynamic responses obtained simulation satisfy requirements addition results reveal frequency control concept based optimised pid controller coordinated enhance frequency stability terms settling time peak peak overshoot
measurement ultra low parts per billion levels small molecule markers body fluids serum urine saliva involves considerable challenge view designing assay strategies sensitivity selectivity herein report first time nano design uniquely combines acid units stacked carbon nanotubes surface gold screen printed electrodes covalent attachment nad dependent formaldehyde dehydrogenase designed enzyme offered formaldehyde detection times urine wide dynamic range ppm fourier transform infrared raman electrochemical impedance spectroscopic confirmed successful design flow injection analysis provided lower detection limit greater affinity formaldehyde apparent ppm compared solution method apparent ppm selectivity assays revealed selective toward formaldehyde moderate similar negligible cross reactivity toward methanol ethanol formaldehyde indoor pollutant studies indicated characteristics systemic toxic effects compound upon chronic high doses exposure moreover reported chromatography mass spectrometry methods identified elevated urine formaldehyde levels patients bladder cancer dementia early stages cognitive impairments compared healthy people results demonstrate carbon nanostructures based design represents novelty simplicity enzyme selective electrochemical quantitation small formaldehyde broader applicability presented approach small molecule markers feasible requires design appropriate marker specific enzyme systems receptor molecules elsevier rights reserved
background oral administered trained health workers effective safe preventing postpartum interest expanding administration non health workers including task shifting pregnant women however use preventing home births remains controversial due limited evidence support self administration leaving hands non health workers study aimed determine pregnant women self home birth reduces methods february march conducted cluster randomized trial six health facilities central women weeks gestation attending care eligible women control arm received standard care intervention arm offered immediately birth baby oxytocin available primary outcome drop postpartum maternal lower prenatal analysis intention treat cluster level used paired tests assess whether mean difference control intervention groups statistically significant results eligible women participate control intervention arms respectively two thousand fifty seven participants successfully followed delivered outside health facility significant difference study group number women received birth control intervention mean difference confidence interval woman took birth fever control arm compared intervention arm mean difference slight non significant reduction percentage women drop control arm intervention arm mean difference similarly significant difference groups primary outcome women delivered home control intervention mean difference conclusion study unable detect significant reduction following distribution
efficient power generation techniques used modern aircraft described form high voltage variable frequency generator advantages enabling electric aircraft discussed machine design aspects system obtained detailed analysis output equation high speed rotating machine case studies taken varying various parameters equation results obtained compared graphically new important conclusions derived study summarized
relevance african herbal medicinal plant pan african distribution immense indigenous medicinal non medicinal applications plant use traditionally remedy numerous disease use wounds healing psoriasis diarrhea stomach also use skin care aim review present review aims date review progress made continuous pharmacological investigation corresponding commercial pharmaceutical application findings ultimate objective providing guide future research plant method scholarly information needed paper predominantly electronic search engines google google scholar publishing sites elsevier pubmed scientific database sites chemicals also online books results pharmacological investigations conducted confirm anti inflammatory analgesic antioxidant anticancer activity extract different parts plant bioactive constituents found present parts plant far approximately compounds characterized different part plant flavonoids major class compounds isolated novel compounds potent antioxidant antimicrobial anticancer effect among others identified commercial trade boosted decades effect maintenance skin recognized resulting skin formulations market conclusions pharmaceutical potentials recognized surge research interest however till date many traditional medicinal uses investigated scientifically probing researches pharmacological activity recommended end goal pharmacokinetics clinical relevance possible toxicity side effects extract active ingredients isolated elsevier ireland ltd rights reserved
systems tuned mass proposed multi mode flutter mitigation long span suspension bridges performance nonlinear systematically compared classical linearly viscoelastic equations motion linearized parametric structural model suspension bridge coupled equations governing dynamics passive nonlinear control system time dependent aerodynamic loads obtained quasi steady nonlinear formulation unsteady theory equations controlled aeroelastic system reduced employing method numerical simulations performed investigate effectiveness vibration system comparing onset flutter post flutter behavior without control devices corresponding responses obtained multiple installed elsevier ltd rights reserved
background leptin adiponectin play important role development hiv aids patients aim study correlate levels leptin adiponectin hiv aids patients without non subgroups mixed fat redistribution non patients methods cross sectional study hiv aids patients serum levels leptin adiponectin measured associations levels metabolic variables estimated spearman correlation analysis covariance method used examine relationship adiponectin leptin categories results observed patients patients significant differences regarding leptin adiponectin levels non patients observed patients significantly higher levels leptin adiponectin comparison non patients respectively within group patients significantly lower levels leptin patients significantly higher levels adiponectin correlation adiponectin remains significant subgroup adjustment age body mass index activator inhibitor interferon gamma ifn gamma conclusions adiponectin leptin levels differ significantly patients non patients subgroups adiponectin useful marker hiv aids patients
cantilever failure involves rapid channel delivers large volume sediment channel important understand mechanism river engineering point view different types failures investigated several previous studies works limitations understanding complex mechanisms cantilever failure regarding coupling erosion failure experiments thus carried assess underlying mechanisms cantilever failure using three types cohesive materials classified basis percentages clay content experiments showed erosion lower part cohesive progressively upper part initial stage cantilever failure tension cracks develop upper surface cohesive beam failure occurs thereafter mathematical model cantilever failure also developed model uses triple grid approach simulate behaviour cantilever within framework erosion subsequent failure simulated results show good agreement experimental results terms spatial averaged bank width water level along cohesive
streptococcus one prevalent pathogens causing clinical subclinical worldwide among bacterial factors involved infections caused organism adhesion molecule one main virulence factors identified molecule involved internalization epithelial cells binding objective study evaluate properties potential subunit vaccine component prevention epitope prediction analysis sequence used identify potentially immunogenic regions since regions detected along gene criterion allow selecting specific region potential hence four fractions comprising protein cloned expressed every fraction elicited humoral immune response mice predicted bioinformatics analysis generated antibodies highest recognition ability towards native protein moreover antibodies produced highest proportion internalization inhibition epithelial cells conclusion immunogenic functionally relevant regions identified allowed propose potential candidate subunit vaccine prevention elsevier ltd rights reserved
recent years increased interest understanding cognitive processes role pathogenesis obsessive compulsive disorder one cognitive factor received little attention rumination rumination defined tendency analyze ones problems feelings distress implicated development maintenance several mood anxiety related disorders thus primary aim current study examine role rumination symptoms using treatment seeking sample multiple regression analyses revealed significant association rumination thoughts neutralizing domain findings remained significant even accounting relevant related construct particular negative affect findings support growing body literature establishing rumination risk factor clinical experimental research needed confirm findings expand knowledge metacognitive models elsevier ltd rights reserved
previous research indicated parents impact minor childrens health behaviors adult childrens health psychological however little known long term consequences parent child relationship adult childrens substance smoking levels low moderate alcohol use adult children age present study uses growth curve analysis longitudinal survey data americans changing lives examine multiple dimensions parent child tie influence adult childrens substance use findings show contact mothers adulthood health enhancing effect sons smoking fathers support related decline alcohol use sons also increase smoking sons findings strain parents complex suggesting ways adult children cope manage strain parents result multiple pathways substance use study raises new questions whether family good bad health calls multifaceted view long lasting parent child tie need look parent child relationship dynamic social tie changes life course consequences health adulthood published elsevier ltd
background major cause injury death sought determine prevalence movie scenes depicted verbal safety messages context health outcomes scenes association motion picture association america ratings scene characteristics methods ten top revenue motion pictures selected year order gross data scenes collected movie using dual monitor computer real time collection tools results seventy movies scenes majority movies rated scenes accounted screen time movies among scenes crime illegal activity involved deaths occurred injuries occurred verbal reference safety made conclusions top revenue movies common safety messages rare major motion pictures present used opportunity education safety
studies described article explore influence emphasized determinant cooperative behavior social affected third parties two experiments examined effect characteristics third parties individual cooperative behavior social identified mechanisms associated relationships study demonstrated third party need affects individual cooperative behavior tested prosocial motivation intra group trust mediators relationship study provided elaboration demonstrating individual cooperative behavior reduced third party low reliability showing prosocial motivation intra group trust mediated relationship research literatures individual cooperation social relational job design demonstrates third parties influence individuals cooperative behavior
long noncoding rnas suggested biomarkers diagnosis prognosis sporadic colorectal cancer study aimed characterize expression profile dna mismatch repair early stage colon cancer microsatellite instability status examined multiplex pcr expression mrna analyzed microarrays differentially expressed mrnas determined bioinformatic analyses validated samples non tumor colonic specimens quantitative real time polymerase chain reaction qrt pcr found comparison five non tumor colonic samples microarray indicated mrnas upregulated mrnas downregulated four early stage bioinformatic analyses revealed differentially expressed mrnas involved process cell division angiogenesis apoptotic differentiation akt tnf pathways others expression mrna networks indicated five hot spots significantly high expression degrees quantitative pcr revealed significantly upregulated downregulated stratification analysis demonstrated significantly associated stage distant metastasis population differentially expressed significantly associated clinical features patients participate tumorigenesis
geotextiles produced arranged prepared produced textile waste materials nonwoven nonwoven blend recycled fibres arranged segments used protection bank deep drainage reinforcement shallow clay ground geotextiles installed ground behaviour one vegetation season observed stated heavy arranged form system micro dams slow stream water flowing surface bank stream flowing along geotextiles installed banks eliminate formation channels protect banks sliding geotextiles absorb water ensures retention water flowing along due enhanced soil water holding capacity geotextiles protect grass seeds facilitate development protective vegetation materials used production reveal sufficient resistance biological degradation slow materials enable keeping protective potential geotextiles least one vegetation season elsevier ltd rights reserved
using intracranial local field potential recordings patients parkinsons disease undergoing deep brain stimulation explored electrophysiological activity nucleus response emotional stimuli auditory modality previous studies focused influence visual stimuli end recorded within response angry happy neutral patients just undergone implantation electrodes observed specific modulation right response anger happiness opposed neutral occurring around post onset later around post onset anger around post onset happiness taken together previous reports modulated activity response emotional visual stimuli present results appear confirm involved emotion processing irrespective stimulus valence sensory modality elsevier inc rights reserved
peripheral cell lymphomas aggressive non hodgkin lymphomas generally poor outcomes following standard therapy candidate therapeutic targets identified date retinoic acid receptor alpha transcription factor modulates cell growth differentiation response used treat cutaneous cell lymphomas mechanism action role mature cell lymphomas remain poorly understood identifying mutation sought characterize role cell lymphoma cells overexpressing wild type significantly increased cell growth low cell lines knockdown induced arrest decreased expression cyclin dependent kinases high cells trans retinoic acid caused dose dependent growth inhibition arrest regulation genes regulated transcriptome data enriched cell cycle transition finally overexpression augmented conclusion drives cyclin dependent kinase expression transition cell growth cell lymphoma synthetic inhibit functions dose dependent fashion effective cells high expression indicating represent therapeutic target
security surveillance increasing need process image data efficiently effectively either source large data network whilst field programmable gate array seen key technology enabling design process viewed problematic terms time effort needed implementation verification work proposes different approach using optimized fpga based soft core processors allows user exploit task data level parallelism achieve quality dedicated fpga implementations whilst reducing design time paper also reports preliminary progress design flow program structure implementation histogram gradients algorithm also reported shows performance achieved design approach whilst avoiding long design time verification steps associated conventional fpga implementations
purpose test delivered multiple behavior tailored intervention healthy pregnancy step step pregnant women addresses smoking cessation stress management fruit vegetable consumption design randomized factorial repeated measures design employed randomization individual level stratified behavior risk women completed three sessions pregnancy two postpartum months setting women recruited six locations funded health centers across three states subjects participants english spanish speaking women weeks gestation intervention treatment group received three interactive sessions focused two priority health behavior risks sessions offered individually tailored stage matched change strategies based model behavior change usual care group received march measures primary outcome number behavior risks stage change continuous measures behaviors also assessed analysis data analyzed across time points using generalized estimating equations examining repeated measures effects results women treatment group reported significantly fewer risks usual care month odds ratio months postpartum conclusion healthy pregnancy evidence based personalized program pregnant women reducing behavior risks sustaining healthy lifestyle behaviors
metastasis accounts high mortality rate associated colorectal cancer crc metastasis regulators fully understood identify novel gene involved tumor metastasis used oligonucleotide microarrays transcriptome distance analyses machine learning algorithms determine links primary metastatic colorectal cancers also known selected focus relationship colorectal cancer requires clarification higher mrna levels observed patients advanced stages cancer suggesting correlation degree malignancy data also indicate overexpression crc cells induced cell migration invasion independent capability like characteristics emt markers also observed induction overexpressing cells regulation cells silencing impaired activity found reduce migratory capacity cancer properties drug resistance vitro vivo therefore suggest enzymatic activity affects tumor initiation cancer malignancy dependent manner results qpcr immunohistochemical staining specimens taken crc patients indicate significant correlation according data analyses mrna expression profiles high expression positively correlated poor crc prognosis act prognostic factor therapeutic target crc metastasis recurrence
governing procedure coupled monte carlo codes relies discretization simulation time time steps typically transport solution discrete points generate reaction rates codes assumed constant within time step assumption trigger numerical result loss accuracy turn require reducing time steps size paper focuses reducing time discretization error without requiring additional transport solutions hence major computational overhead sub step method presented accounts reaction rate variation due variation densities thermal hydraulic conditions achieved performing additional depletion calculations within analyzed time step method implemented code subsequently used analyze series test cases results indicate computational speedup factor achieved existing coupling schemes elsevier ltd rights reserved
past years reversible techniques relational databases proposed provide protection ownership rights data data integrity mainly techniques ensure original data recovery data whereas irreversible schemes protect ownership rights characteristic reversible emerged candidate solution protection ownership rights data modifications medical data genetic data credit card bank account data main objective paper make extensive survey state art reversible techniques relational databases reflect recent research progress point key issues future research order analyze techniques classification performed basis extent modifications introduced scheme underlying data robustness embedded malicious attacks copyright john wiley sons ltd
purpose benign masses relatively rare aim study create higher awareness entities point reliable diagnostics accurate treatment methods medical records department obstetrics gynecology searched number type surgery general surgery took place particularly owing benign period years diagnostics treatment histology postoperative management summarized analyzed vaginal manifestations considered results total number women underwent surgery particularly benign benign patient cohort composed follows squamous epithelial inclusion duct epidermal inclusion solitary fibrous tumor masses due materials occurred asymptomatic accompanied symptoms case history clinical examination pelvic floor mri essential tools diagnostics simulated cause overactive bladder pain women stress urinary incontinence cases one case infected completely conservative antibiotic therapy conclusions awareness benign helpful diagnostics management secondary pathology malignancy considered
transgenic animal extensive perspective research application field medicine life science reason scientists explored convenient easy economic practical high performance transgenic methods injection method transfer foreign gene sperm avoid inhibitory factor complicated dealing sperm ensuring fertilization embryo development recombinant efficient expression made plasmid backbone antimicrobial peptide sequence constructed region linear vector injected testis chicken surgical operation collected transgenic chicken embryos pcr southern blotting results revealed positive transgenic chicken embryos transgenic rate southern blotting results showed foreign gene integrated chicken chromosomes multi inserted repeat sequences
research risk factors adults tendencies limited still unclear whether association tendencies non clinical individuals exists goal present study test associations tendencies self perception personality traits depressive symptoms among non clinical adult population investigated italian sample adults administered set self report questionnaires assess obsessive compulsive tendencies depression self perception personality traits confirmatory factor analyses performed final model found personality obsessive compulsive factor suicidal ideation significantly correlated personality correlated negatively obsessive compulsive factor suicidal ideation obsessive compulsive factor suicidal ideation resulted strongly positively associated results highlight importance assessing tendencies negative self perception understanding role interplay allow development implementation advanced prevention treatment policies
study proposes new design method active mass damper based auto exogenous models building structure proposed method uses results system identification field active structural control uncontrolled structure identified auto exogenous models via measurements earthquake excitation forced vibration models linked equation motion introduce state equation output equation structure interaction system discrete time space equations apply modern control theories design numerical applications degree freedom building structure linear quadratic regulator control used understand fundamental characteristics proposed design procedure feedback control law requires acceleration velocity stroke structures acceleration ground acceleration vibration measurements numerical examples confirm high applicability control effectiveness proposed method one remarkable advantage proposed method equation motion structure becomes unnecessary designing controllers copyright john wiley sons ltd
background past decades bariatric surgery especially gastric bypass become widely considered effective treatment morbid obesity cases results enhanced glucose management patients obesity type diabetes observed significant weight loss however accounts effect remains controversial gain insight benefits investigated changes beta cell mass obese rats following material methods sham operation performed obese rats fed high fat diet weeks continued weeks groups additional normal diet obese groups used controls results present study induced improved glycemic control enhanced beta cell function reflected better glucose tolerance rapidly increased secretion insulin peptide glucose administration consistently rats group displayed increased beta cell mass numbers attributed part increased like peptide levels following conclusions data indicate improve beta cell function via increasing beta cell mass plays key role improved glycemic control
reasonable determination cable tensions main cable configuration key issue designing suspension bridges based interacting matrix theory optimisation method cable force suspension bridges deduced linear structure interacting matrix linear non linear structure suspension bridge large deformation effect strong superposition principle applicable interacting matrix theory applied especially linear structure interacting matrix suspension bridge taking account dead load stiffness based interacting matrix cable forces iterations non linear fem procedure consists two successive steps non linear analysis first step interacting matrix formation procedure interacting matrix suspension bridge taking account dead load stiffness successive non linear analyses performed trial nodal coordinates lengths cable elements resulted target optimisation procedure designated targets achieved concerning structure stiffness reasonable shape suspension bridge addition case study suspension bridge carried show capability proposed method showed method advantages mechanical significance concise algorithm high accuracy worth design practice
males outperform females spatial tasks partially due effects sex steroids spatial strategy preferences previous work rodents indicates low estradiol levels bias females toward striatum dependent response strategy whereas high estradiol levels bias toward hippocampus dependent place strategy tested whether testosterone influenced strategy preferences male rats subjects assigned one three daily injection doses testosterone rat control group received daily injections drug vehicle three different maze protocols used determine rats strategy preferences low dose testosterone biased males toward motor response strategy maze task water maze task platform used visual cue low testosterone dose caused significant increase use response strategy relative control males results second experiment also indicated males receiving high dose testosterone biased toward place strategy third experiment indicated testosterone dose strong influence ability rats use nearby visual cue floating ball water maze experiment groups seemed use combination place response strategies overall results indicate effects testosterone spatial strategy preference dose dependent task dependent elsevier inc rights reserved
present work case spain shown considered one extreme examples mediterranean coast severe pathologies associated urban development coastal partially built deep affects soft formation composed dark graphite november city council state emergency already used two remote sensing techniques monitor aim identifying measuring wide range displacements rates year year exploiting sar images acquired december photogrammetry considering output two unmanned aerial vehicle uav made june january photos conventional flight relationship site data deformation measurements building displacements rainfall damage observed temporal occurrence allows better understanding kinematics spatial temporal evolution instability results indicate building displacements years clear control spatial distribution damage close relationship damaging events water recharge episodes rainy events swimming pools water supply network work need incorporate urban planning including policies predict prepare prevent type phenomenon
technologies promise increase access care particularly communities however little known private vary non services use largest private claims database united states provided health care cost institute identify claims compare average non claims find average services significantly lower non seven ten common services example office visits evaluation management established patients low complexity lower corresponding non service clinical diagnosis code also tended lower non claims widespread adoption hampered lower services relative face face services result lower incentives providers technologies result significant cost savings practice even improves patient outcomes
objective review current neuromodulation treatments available migraine therapy acute preventive setting methods published literature reviewed studies reporting effects different neuromodulation strategies migraine without aura use non invasive single pulse transcranial magnetic stimulation non invasive nerve stimulation nerve stimulation transcranial direct current stimulation invasive methods occipital nerve stimulation ganglion stimulation assessed results available evidence shows non invasive techniques represent promising treatment strategies whereas invasive approach used patients refractory including non invasive methods conclusions neuromodulation emerging exciting approach migraine therapy especially context failure commonly used medicines patients tolerate common side effects studies appropriate strategies needed confirm results new treatment opportunities
mitogen activated protein kinase phosphatase expression induced inflammatory factors serves endogenous mapk suppressor limit inflammatory response glucocorticoids effective anti inflammatory drugs used treatment many inflammatory diseases asthma copd investigated role inhibition cytokine production dexamethasone human bronchial epithelial cells found dexamethasone increased expression inhibited mapk phosphorylation suppressed tnf alpha production cells interestingly suppression mapk phosphorylation inhibition tnf expression dexamethasone attenuated cells expression sirna conclusion data suggest dexamethasone increases expression results suppression mapk signaling leading inhibition cytokine production human bronchial epithelial cells results point role important factor therapeutic effects glucocorticoids treatment inflammatory lung diseases
research focused control vehicle suspension means magnetic resistant force coming generating process suspension system kinetic energy transformed electrical energy designed transmission mechanism converts translational motion rotational motion combined pole generator resistant force generating current occur vibrations theory electrical generator known exciting current generator determine resistant force play important role control system hence paper new adaptive controller properly designing exciting current proposed actively control suspension system experiments performed demonstrate feasibility devised control scheme
background although care organizations defined provision primary care services relationship intensity primary care population level utilization costs health care services examined early implementation medicare shared savings program objective evaluate association primary care focus healthcare utilization spending first performance period medicare shared savings program care organizations methods retrospective cohort study divided primary care focus based percentage ambulatory evaluation management services delivered family physician using multivariable regression evaluated rates utilization spending initial performance period adjusting percentage non white patients region number months enrolled number person years percentage dual eligible beneficiaries percentage beneficiaries age results proportion ambulatory evaluation management services delivered ranged highest quartile greatest focus highest quartile focus higher adjusted rates utilization acute care hospital admissions per person years per person years emergency department visits per person years compared lowest quartile focus highest quartile focus achieved greater savings per relative spending benchmarks benchmark benchmark conclusions primary care focus associated increased savings lower utilization healthcare initial implementation
australia approximately people diagnosed hiv accessing treatment receiving treatment fail achieve viral suppression barriers limiting effective care warrant examination mixed methods systematic review accessed health social sector research databases november december identify studies explored perspective people living hiv australia articles included analysis described experiences knowledge attitudes beliefs relation treatment uptake adherence published january december quality appraisal utilised mixed methods appraisal tool version seventy two studies met inclusion criteria reviewed interplay lack knowledge fear stigma physical emotional social issues found negatively impact treatment uptake adherence strategies targeting individual wider community needed address barriers
following widespread implementation large projects huge need finish time importance final product quality safety standards large scale projects necessity field management felt ever study conducted investigate evaluate compliance various known standards project management civil projects achieve efforts made using statistical analysis multi criteria decision analysis method expert opinions analyze compliance standards development projects provide usable solutions improve management projects according results observed standard best option followed standards respectively
suitable piece software presented connect sophisticated finite element package matlab comprehensive program mathematical analysis interface known codes benefits image processing integrated graph features matlab also opens new opportunities results post processing statistical analysis mathematical optimization among many possibilities software architecture usage appropriately described two problems particular engineering significance addressed demonstrate capabilities firstly software employed assess cleavage fracture novel probabilistic framework potential create train neural networks used identify damage parameters hybrid experimental numerical scheme model crack propagation structural materials means cohesive zone approach source code detailed documentation large number freely downloaded elsevier ltd rights reserved
located shanghai radiation facility first dedicated biological material small angle ray scattering electrons come provide high end stations double flat silicon crystal used tunable photon energy ranging meet rapidly growing demands structural allows manual automatic sample loading detector employed data collection characterized high dynamic range short readout time highly automated data processing pipeline integrated help group european molecular biology laboratory provides user friendly interface data processing opened users march date feedback users positive number experimental proposals increasing description new setup characteristics given together examples data obtained
integrity prerequisite sustained knee joint health prevention degeneration main research goal cartilage protective effects selenium described little known impact therefore investigated influence sodium explants tumor necrosis factor alpha tnf alpha stimulated proinflammatory conditions isolated year old cattle incubated tnf alpha sodium low dose found insulin selenium medium supplements medium dose med described physiological synovial concentration high dose described optimal serum concentration days culture release assay nitric oxide production assay gene expression matrix degrading enzymes quantitative apoptosis rate determined tnf alpha led significant raise release production med significantly reduced tnf alpha induced release respectively production respectively apoptosis respectively med showed tendency reduce tnf alpha mediated increase inducible synthase inos levels furthermore matrix metalloproteinase mmp transcription levels metalloproteinase motifs levels less pronounced med show substantial impact early inflammatory response knowledge first study showing protective influence selenium tissue maintenance understand superior potency low dose selenium molecular level future studies needed
objectives reflux felt separate upper gastrointestinal conditions aimed measure degree overlap assess whether endoscopic findings differed material methods demographic symptom upper endoscopy histology data collected consecutive adults secondary care patients according whether reported reflux alone alone patient demographics endoscopic findings compared results patients reflux alone alone overlap patients overlap symptoms likely smoke compared reflux alone alone differences patients reflux alone overlap higher prevalence respectively still commonest diagnosis among alone significant differences seen prevalence endoscopic findings conclusions reflux symptoms commonly overlap minimal differences demographics spectrum underlying organic disease various symptom groups suggesting restrictive classifications according predominant symptom clinically useful
accurate image registration vital step many computer vision processes however traditional based methods able obtain satisfactory results cases paper turn matching problem markov random field optimization problem propose fast accurate image registration method based message passing screen caused conventional based algorithm proposed method comprises three steps first detector used detect key points points described instead detector improve efficiency second new geometric constraint distance direction terms designed incorporated sequential tree message passing obtains coarse matching result finally algorithm adopted filter obtain accurate transformation experimental results demonstrate proposed method significantly improves efficiency accuracy registration process desirable result
peoples perception environmental socio economic impacts due three hydro electric projects construction studied north west indian surveys among project affected people using checklist impacts indicate among negative impacts decrease flora agriculture flow river aesthetic increase water pollution river bed sand stone human settlement river banks social among positive impacts increase standard living road connectivity means transport public tourism environmental awareness related tend negative impacts age becomes functional positive impacts seem negative impacts study concludes difficult separate impacts due construction anthropogenic natural factors absence cause effect analyses hard prevailing notion undesirable study area led stopped construction one overcome situation multi disciplinary scientific studies involving need carried planning decision making make environment friendly sustainable region also need adopt low carbon electric power technologies promote decentralized energy strategy joint public private companies utilizing locally available renewable energy resources
study used theory examine effects colour similarity boundary web page content colour similarity elicit scanning behaviour improve attitudes towards using pre attention stage eye tracking device used record analyse participants eye movement psychological scale used measure participants brand attitudes results suggested using background similar web page content increases fixation time fixation count addition results revealed longer fixation time higher fixation count increase positive attitudes towards brand results clarify relationship exposure brand attitudes provide physiological information relevant commerce
although evidence heterogeneity asthma accumulated consensus definitions asthma phenotypes still lacking obesity heterogeneous effects various asthma phenotypes aimed distinguish asthma phenotypes latent class analysis investigate associations different obesity parameters adults using population based swiss cohort applied latent class analysis self reported using information disease activity atopy age onset associations obesity examined multinomial logistic regression adjustments age sex smoking status educational level study centre body mass index percent body fat waist hip ratio waist height ratio waist circumference used obesity measure four asthma classes identified including persistent multiple symptom presenting asthma symptom presenting asthma symptom free atopic asthma symptom free non atopic asthma obesity positively associated symptom presenting asthma classes symptom free ones percent body fat showed strongest association persistent multiple symptom presenting asthma observed heterogeneity associations obesity across asthma classes indicating different asthma authors published elsevier ltd
data computational domain stored digital format format data consumes less effort storage thus number organization institutes preserving information format presented work data privacy main area study proposed work organization considered decisions made different department based data attributes additionally make decisions attributes departments required departments able disclose privacy data owner therefore combine data attributes mining combined data need privacy preserving technique preventing privacy issues database paper demonstrate different departments organization combine data without privacy client making effective decisions efficient accurate manner thus method vertically data combination cryptography decision mining demonstrated mine decisions data decision tree used implementation proposed privacy preserving data mining decision making technique performed using java technology additionally performance system computed terms accuracy error rate memory consumption time consumption finally justify outcomes proposed data mining technique traditional tree using tool used data comparative performance study experimental results show effective performance security given privacy preserving technique
frequent laboratory finding diagnosis therefore elevated platelet counts require careful diagnostic work differentiate reactive caused various conditions essential thrombocythemia myeloproliferative neoplasm mpn either setting aspirin widely used clinical practice however even platelet counts never shown cause thrombosis bleeding due acquired von factor defects association high platelet counts identification reactive conditions appropriate therapy underlying disorder relevant contrast related mpn associated thrombosis hemorrhage current recommendations suggest use low dose aspirin patients unless however strength recommendation weak evidence level grade potential benefit aspirin used primary mostly derived study polycythemia vera however translating study results appears highly biased absence robust data regarding benefit risk balance aspirin appears reasonable patients according individual thrombotic bleeding risk restrict use aspirin high risk categories patients disturbances test pharmacological efficacy cox inhibition measurement modify aspirin dosing regimen twice instead daily required
cause renal dysfunction diabetes mechanisms underlying induced understood elucidate early molecular changes responsible disorder employed mass spectrometry based proteomic analysis inner collecting isolated parathyroid hormone treated rats onset induced forty one proteins including water channel exhibited significant changes abundance decreased bioinformatic analysis revealed many downregulated proteins associated cytoskeletal protein binding regulation actin polymerization cell cell junctions targeted studies confirmed downregulation proteins identified initial proteomic analysis additional experiments using vitamin treatment model induced evaluation transcript levels estimated half life downregulated proteins suggested enhanced protein degradation possible regulatory mechanism electron microscopy showed defective intercellular junctions autophagy cells vitamin parathyroid hormone treated rats significant increase number confirmed immunofluorescence labeling downregulated proteins found models electron microscopy revealed cells models finally parathyroid hormone withdrawal reversed phenotype accompanied termination degradation normalization phosphorylated levels thus enhanced degradation proteins plays important role initial mechanism induced
present brief survey history development mechanical theories strength materials advantages drawbacks physically reliable experimentally justified criterion equivalence materials established structure criterion determined according results analysis equation limiting surface whose shape satisfies necessary sufficient requirements imposed principal mechanics deformed body corresponding equation contains used control shear tensile fracture degrees responsibility mechanisms put correspondence parameter plasticity material appearing equation form weight coefficient determined according results testing tension compression condition limiting state materials inhomogeneous structure established introducing criterion influence function taking account statistical aspects strength materials connection presence weak places defects analysis structure influence function reduced solution problem probability theory repeated sampling given volume
model describing deformation allowing damage material presented effect stresses temperature creep strain rate variations evaluated scalar function damage validity approach demonstrated creep description steel within rather wide stress temperature ranges
big data term roots described innovative technique technology save distribute manage visualize analyze larger sized data extreme velocity methods manage unstructured structure amount data big data high capacity predict conclusion low cost consumption increase efficiency enhance decision making various fields like management control improve business transaction existing system amount customers services online transaction grown rapidly often suffer scalability problems processing analyzing large scale data nowadays transactions real time increasing identifying large scale patterns across many transactions detecting anomalous behavior individual user change online transaction thus banks turning analytics predict prevent real times detection traditionally focused factors known bad addresses unusual times project proposed system deals credit card management improve scalability efficiency big data environment implemented hadoop distributed file system widely adopted distributed computing platform using map reduce parallel processing paradigm stores large files typically range across multiple machines hand nowadays web attacker increased steel order overcome proposed system implements concept add security credit card transaction changes include stronger user authentication tool require associates follow new steps network remotely random number generation authentication solutions provide next generation one time secure access computers networks internet engineered enhanced authentication methodology system using device less provides users simple secure way access information leveraging existing uses one time used added security ability protect applications systems
background objectives dental important healthcare challenge adults years age integration oral health screening non dental primary care practice improve access preventive dental care vulnerable populations elderly integration require easy fast accurate early detection tools primary goal study evaluate diagnostic performance optical coherence tomography oct imaging detecting early elderly living community based settings international detection assessment system served gold standard secondary goal study provide baseline prevalence data early lesions independent living adults aged years materials methods seventy two subjects recruited three sites southern california community senior health fair hospital clinical examination performed using visual criteria followed oct imaging two dimensional oct images scan analyzed simple software locations log back scattered light intensity scored sound areas exceeding considered diagnostic performance oct imaging compared score results oct based diagnosis demonstrated good sensitivity good specificity subjects least one tooth early conclusions early decay prevalent surfaces teeth independent living adults aged years though oct imaging coupled simple diagnostic algorithm accurately detect areas early community based settings existing devices expensive suited use non dental health care providers simple inexpensive fast accurate tools early detection field health care providers working non traditional settings urgently needed support inter professional dental health management wiley periodicals inc
among related long non rnas screened gene chip preliminary study attracted attention high conservation across different species significant positive correlation literature bioinformatics analysis suggested associated cell growth invasion apoptosis expression severe normal evaluated real time reverse transcription polymerase chain reaction qrt pcr constructed silencing vector sirna explore biological function development progression cells vitro furthermore utilized analysis transwell invasion assay flow cytometry determine role proliferation invasion apoptosis cells proteins related proliferation invasion mmp apoptosis caspase bcl evaluated western blot assay results showed obvious upregulation expression placental tissues addition silencing enhanced cell proliferation invasion reduced cellular apoptotic response taken together findings suggest first time abnormal expression lead aberrant biological behavior cells therefore propose novel molecule contribute development represent potential diagnostic therapeutic target disease wiley periodicals inc
predictions different magnetic core losses acceptable accuracy key parameters temperature rise calculations considered rate large hydro electrical machines common practice hydro electrical designers compute core losses different section machine function flux density given manufacturer steel probably leads inaccurate prediction magnetic core losses paper certain currently available core loss models used compute electromagnetic core losses large hydro electrical machine obtained results discussed compared available test data
background selection representative mass profiles rheumatoid arthritis serum samples developed allows selection identification potential biomarkers serum samples methods controls samples analyzed using maldi tof two different protein procedures utilizing examined statistical evaluation data performed using different feature selection methods combination different classifiers identification selected masses performed using maldi tof tof results utilization proposed statistical strategy allowed selection different masses according method procedure obtained masses subjected targeted identification panel proteins identified potential markers role proteins discussed relation conclusion application advanced analysis obtained maldi tof datasets resulted targeted selection potential biomarkers five proteins identified due procedure six proteins identified due procedure respectively panel identified proteins suggest presented statistical methodology proteomic strategy correct gave valid results obtained results contribute development clinically useful diagnostic tool elsevier inc rights reserved
recently propose sharing digital image scheme shares color secret image two shadow images based boolean exclusive operation three types shadow images als noise like black white meaningful color meaningful shadow images however exist als incorrect assignment color data color index erroneous recovery secret image partial region shadow image revealing cover image paper solve weaknesses propose new experimental results demonstrate scheme effectively avoids weaknesses
background research shown suicide phenomenon highly present among drug dependent population different studies demonstrated level comorbidity personality disorders substance use disorders sud study aimed describe frequent among patients risk suicide methods study based consecutive non probabilistic convenience sample patients attended public addiction center spain sociodemographic data suicide drug related characteristics recorded risk suicide assessed spanish version risk suicide personality disorders measured spanish version clinical inventory results associated presence risk suicide depressive avoidant borderline disorders however compulsive inversely associated risk suicide even though scale statistical correlation conclusions risk suicide significant factor take account related patients sud especially presence specific findings underline importance diagnosing treating rigorously patients sud
visual cryptography many shares generated containing certain message within shares jointly tend expose secret image notion visual secret sharing scheme secret image share images unable reveal data original image least one shares achieved original image fact realized overlapping entire shares directly order human visual system competent identify collective secret image without employing complicated computational tools therefore communicated steadily number shares elliptic curve cryptography approach turn employed augment privacy safety image new technique utilized generate multiple shares subjected encryption decryption means elliptic curve cryptography technique test outcomes revealed fact peak signal noise ratio mean square error value correlation coefficient image without sort distortion original image
force microscopy probes mechanical deformation sample response electric field applied tip atomic force microscope originally developed two decades ago study materials technique since used probe electromechanical functionality wide range piezoelectric materials including organic biological systems force microscopy also demonstrated useful tool detect mechanical strain originating electrical phenomena non piezoelectric materials advances analytical numerical modelling many technical improvements made last decade switching spectroscopy allows switching properties resolved real space resolution dual resonance tracking band excitation used improve signal noise ratio turn advances led increasingly large multidimensional data sets containing complete information properties sample studied review operation calibration described recent advances characterisation electromechanical coupling using presented breadth systems covered highlights versatility wide applicability fields diverse materials engineering fields combining complementary techniques key develop future insight intrinsic properties materials device applications
purpose paper develop constructive versions module structure rings partial differential operators polynomial coefficients base field characteristic zero generally based results develop constructive versions simple domains based fact certain inhomogeneous quadratic equations solutions simple domain show explicitly compute element generated left module rank least two result used decompose generated left module direct sum free left module left module rank one latter free explicitly show left ideal generated two elements give algorithm reduces number generators presented left module module relations rank least two particular generated left module generated two elements image ideal whose construction explicitly given moreover non non free left module rank generated elements fewer results implemented package system theoretical interpretations given within module approach finally prove results also hold ring ordinary differential operators either formal power series locally convergent power series coefficients using result also ring partial differential operators coefficients field fractions ring formal power series ring locally convergent power series
plasma testosterone levels display circadian variation sleep reaching late rhythm pulses every min reflecting underlying rhythm luteinizing hormone secretion increase testosterone sleep rather circadian rhythm dependent requires least sleep normal architecture various disorders sleep including abnormalities sleep quality duration circadian rhythm disruption sleep disordered breathing result reduction testosterone levels evidence support direct effect sleep restriction circadian rhythm disruption testosterone independent effect sex hormone binding globulin presence comorbid conditions balance seems obstructive sleep apnea appears direct effect testosterone adjusting age obesity however possible indirect causal process exist mediated effect obesity treatment moderate severe continuous positive airway pressure reliably increase testosterone levels studies contrast reduction weight linearly proportion amount weight lost apart transient deleterious effect testosterone treatment adversely affect data effect sleep quality testosterone depend whether testosterone given replacement doses context abuse experimental data suggest testosterone modulate individual vulnerability subjective symptoms sleep restriction low testosterone affect overall sleep quality improved replacement doses large doses exogenous testosterone steroid abuse associated abnormalities sleep duration architecture
gas chromatography indispensable analytical technique ever since first exciting steps application fatty acid plant breeding biosynthesis human metabolism present day methods high quality capillary columns allow sensitive reproducible fatty acid analyses characterization complex mixtures geometric combined chromatographic spectroscopic identification ordinary analysis suited detailed follow changes human tissue fatty acids derived dietary providing however steps methodology carefully optimized plasma fatty acids act excellent indicators use substitute found dose dependent correlations analysis phospholipid fatty acid composition especially useful recognizing competitive capability essential fatty acids present particular dietary fat clear response observed even level minor fatty acids increased decreased use trans fatty acids indicated changes abundant trans addition expected associations serum lipids plasma fatty acid data also useful monitoring relationships lipid oxidation parameters analysis fatty acids still traditional uses now faced new challenges since effects arise even moderate amounts dietary essential fatty acids neglected continuing research aimed requirements prime importance modification fatty acid compositions metabolic engineering offers good possibilities producing new crops balanced alpha acid ratio combined high acid content future particular attention paid proportions polyunsaturated fatty acids diet factors finally determine apparently unique balance tissue fatty acids decisive human health elsevier science rights reserved
emergency contraception safe effective method used prevent unwanted pregnancy unprotected sexual intercourse many unwanted pregnancies end unsafe search ideal contraceptive interfere sexual act yet effectively controls fertility still continuing numerous contraceptive techniques available yet contraceptive coverage continues poor india thus even planning pregnancy exposure unprotected sex takes place often use emergency contraception need also arise due failure contraceptive method used condom rupture oral pills following sexual assault emergency contraception intervention prevent large number unwanted pregnancies resulting failure regular contraception unplanned sexual activity turn helps reducing maternal mortality morbidity due unsafe however concern expressed regarding repeated usage pill currently rational use emergency contraception promoted expected make significant reducing number unwanted pregnancies unsafe fact since introduction emergency contraception contribution unsafe abortion towards maternal mortality declined per cent
background antioxidant hypothesis regarding risk asthma childhood resulted inconsistent findings data indicate role antioxidants childhood asthma risk critical time window effect designed longitudinal cohort study clarify hypothesis objective study longitudinal associations serum concentrations first years life asthma risk age years methods based case control design nested within finnish birth cohort asthma cases matched controls birth time sex genetic risk birth place non fasting blood samples collected ages years serum analysed parents reported presence age start persistent doctor diagnosed asthma child age years data analyses conducted using generalized estimating equations results find strong associations serum risk asthma based age specific longitudinal analyses lower higher alpha gamma increased risk asthma conclusions current findings support suggestion increased prevalence asthma consequence decreased intake antioxidant nutrients moreover confirm critical time window impact antioxidants asthma risk replication findings similar longitudinal settings strengthen evidence base
essay examine regarding poverty sexual crime free state radical journal man commitment rights women poor anti establishment era political leadership insecure manage free states news agenda something attempted service viewed acceptable image life free domestic foreign viewed policy manifestation social political free states leadership aided gave wider free state society forces damaged interests vulnerable sections society particular nations women children living however reputation free state largely lost history
purpose study examine effects smoking cessation male college students experimental group received specific smoking cessation whereas control group received sham nonspecific participants received weeks intervention experimental group applied lung stomach mouth data nicotine dependence self efficacy smoking cessation exhaled carbon monoxide collected group times intervention weeks intervention weeks intervention statistical differences two groups pretest posttest emerged self efficacy smoking cessation exhaled carbon monoxide nicotine dependence
background atopic dermatitis eczema inflammatory skin disease associated significant impairment quality life important objectively quantify cutaneous biophysical measurements research therapeutics evaluate skin correlate disease severity quality measured standardized condition eczema severity score childrens dermatology life quality index correlated age disease severity quality life correlated age trend conclusions skin increase age correlates disease severity correlates neither severity quality life score objective measurement two signs replace clinical measurements severity quality life limited scope eczema research therapeutics
hospital lung transplantation negatively affects quality life resource utilization secondary analysis data collected prospectively conducted identify pattern incidence count cumulative duration reasons predictors lung transplant recipients assessed discharge majority multiple median cumulative duration days main reasons infection rejection infection rejection infection rejection required odds ratio discharged care facilities higher risk cumulative incidence thirty day significantly predicted baseline characteristics predictors higher count lower capacity engage self care incidence rate ratio discharge care facilities predictors longer cumulative duration older age arithmetic mean ratio return intensive care unit lower capacity engage self care identifying risk assist optimizing care discharge planning long term follow hospital lung transplantation common primarily reasons infection rejection predicted initial discharge care facilities poor engagement self care older age return icu
background purpose receiving clear complete date information satisfying relationship health professional primary importance patients healthcare organization plays key role promoting effective relationship communication patients present study aims explore care organization service characteristics provided italian centres best predict patients satisfaction healthcare methods eighty one centres patients women mean age years mean education years time since diagnosis years included analysis care organization service provided centre evaluated comparison national institute health care excellence guidelines management patients satisfaction care measured using patient self assessed questionnaire revised section section results clinical characteristics patients significantly affected satisfaction multivariate regression model showed higher patients satisfaction score inversely associated hospital size number patients care beta confidence interval directly associated psychological interventions confidence interval conclusions multiple sclerosis patients larger hospitals less satisfied information received relationship building individualized relationship patients tailoring communication information improve patients satisfaction goal probably less likely accomplished larger centres many incoming patients moreover centres also provide structured psychological interventions patients satisfied
alpha acid unusual fatty acids omega omega series play important role modulation human metabolism presence acids leaves several wild plants recently reported study six wild species selected order establish fatty acid compositions leaf lipids thus young leaves rock major yielded lipids per dry plant material silica gel chromatography yielded major neutral lipids major per dry weight gas chromatography showed major fatty acids omega omega fractions high concentrations omega fraction mass analyses reveal presence unusual fatty acids found high concentrations ranging analyzed plants rich sources essential fatty acids omega omega also
synthetic aperture radar sar tool allowing near real time imagery large ground areas hundreds wide sar also allows persistent observations process oil discharges day night observations independence cloud cover high frequencies interpretation sar scenes lower basin period allowed recognition natural associated individual sites acquired additional sar data set short revisit time selected area data set consisted sar scenes acquired day period meaning maximum period subsequent sar short term approach shows detected wind speeds long term short term monitoring evidences events intermittent occurrence rate oil release ranging short term monitoring shows pace independent sites suggesting contrasted controlling factors also shows residence time systematically shorter far reported values understanding residence time essential provide accurate estimation fluid flow compute volumetric outflow integration situ points measuring current velocity sea surface addition local wind field length allowed accurately estimate residence time oil sea surface results show sea surface residence time oil limited hours median value min new residence time estimations allowed propose quantification regional oil output lower basin estimated year area therefore considered worlds third biggest oil supplying province natural elsevier inc rights reserved
recent decades water conservation become increasingly utmost important issue debate includes domestic sector reducing demand water improving efficiency water use domestic sector requires understanding water used ways water savings realized focus global web based consumer questionnaire survey analyze individual consumer attitudes towards using water manual understand likelihood prospect changing daily manual method resulting efficient domestic usage water study designed investigate manual technique used households nine different countries china germany italy russia brazil india south africa besides socio demographics technical questions like cleaning steps hygiene questions motivational question environmental awareness questions questions payment water electricity questions information sources household work included study found awareness water common among asian participants necessarily practiced households individual washing found quite high among many outcomes important one running tap method found prevalent among russian participants approach towards domestic water usage south american countries like brazil high occurrence running tap found common practice confirming lack conscious use water manual based overall responses awareness new efficient technique manual internet
new configurations realizing inverse inverse inverse inverse filters using commercially available current feedback accessible terminal presented proposed circuits confirmed experimental results employing type
interface shear strength soil structural materials dependent pressure increase pressure different methods reinforcement materials carbon fiber reinforced polymer used shear strength improved soil dependent interface properties soil objective study investigate interface properties friction angle adhesion sand experimentally using direct shear test apparatus increase surface roughness improve interface properties layer sand placed saturated carbon fiber period spark plasma sintering normal stress applied sand interface shear tests conducted different times shear rates normal stresses time tests showed normal stress time increased friction angle increased however increasing times rate small influence interface properties
paper focuses extending recently proposed damage localization method previously devised structures subjected known input ambient vibrations induced unknown wind excitation wind induced vibrations long span bridges recorded without closing infrastructure traffic providing useful data health monitoring purposes one major problem damage identification large civil structures scarce data recorded damaged real structures detailed finite element model able correctly reliably reproduce real structure behavior ambient excitation tool enabling simulation several different damage scenarios test performance monitoring system work calibrated finite element model existing long span suspension bridge used simulate structural response wind actions several damage scenarios simulated different location severity damage check sensitivity adopted identification method sensitivity length noise disturbances recorded data also investigated
texture feature extraction methods improved greatly recent years widely known local texture feature descriptor achieve desired performance change image geometric size different poses complex illumination conditions paper novel local texture descriptor proposed named multi degrees improved local difference binary local difference binary promising feature description method computes intensity gradient difference pairwise grid cells image grid inherent texture gradient difference represent difference texture information grid cells intensity gradient simultaneously addition multiple degree strategy adopted achieve texture description time optimized mutual information proposed capture discriminant feature selection reduce dimensionality experimental results demonstrate proposed method highly efficient distinctive compared several state art approaches due good performance expected potential widespread application many computer vision fields
exploratory research aims evaluate indoor environmental quality classrooms three school buildings southern canada evaluate schools teachers perception classrooms indoor environment schools include middle aged conventional school new non green school new green school certified using leadership energy environmental design rating system methodology involved using mobile instrument conduct measurements thermal comfort indoor air quality lighting classrooms survey evaluate teachers long term satisfaction classrooms indoor environmental quality results showed new green new non green schools classrooms performed better conventional middle aged schools classrooms respect aspects thermal comfort indoor air quality teachers new green school new non green school satisfied teachers conventional middle aged school classrooms overall indoor environmental quality lighting quality indoor air quality surprisingly new green new non green school classrooms performance comparable new green schools classrooms performing statistically significantly better respect relative humidity similarly none differences teachers satisfaction ratings new green new non green school statistically significant
article considers contribution research make resolving communication problems women identified leadership practices within fields gender language workplace discourse research practitioner research resolve work related communication problems still uncommon article presents study senior leader engineering company find experiencing communication problems teams using analysis able show authority gendered linguistic grounds making case research discuss use insights discourse analysis offer guidance practitioners seeking help
since long term performance largely determined deformation soil around study soil deformation characteristics vehicle loads important especially soft soil area based series dynamic cyclic tests deformation characteristics saturated clay studied result shows failure cyclic stress amplitudes csa failure cyclic stress ratio occur strain plastic strain reaches approximately respectively accordingly development cyclic plastic strain categorized three types steady state rapid growth instantaneous failure stress level failure csa development strain nearly linear plastic strain prevent control engineering geological hazards induced vehicle loads vibration amplitudes clay around tunnel axis closely monitored attention paid soil deformation early operation stages line clay sensitive external loads strength soil shallow ground considered basic parameters study design results paper contribute design maintenance prevention control tunnel axis deformation
first revision database covering human phase enzymes isoforms pesticides related compounds original version included enzymes revision also includes insect wiley periodicals inc
change impact analysis process determining consequences modification software theory change impact analysis done software maintenance make changes introduce new many approaches techniques proposed help programmers change impact analysis automatically however still open question whether programmers change impact analysis paper conducted two studies one depth study one breadth study depth study recorded videos nine professional programmers two two hours breadth study surveyed professional programmers using online system found programmers studies static change impact analysis made changes using functionalities dynamic change impact analysis made changes running programs also found use change impact analysis tools
article discusses potential complement analytical toolkit agricultural extension statistical modelling adoption agricultural practices tended use categorical regression models focusing single technology practice explained number household farm characteristics bayesian network used model household level data adoption practices discuss advantages modelling complex data structures including multiple practices implemented jointly farms correlation probabilities implementation practices iii correlation household farm characteristics paper demonstrates use reasoning regarding adoption practices answering questions regarding probability implementation combinations practices conditional household characteristics complementary modelling approach logistic regression analysis facilitates exploring causal structures data deciding reduced form regression model uniquely used answer questions regarding likelihood certain household characteristics conditional certain practices adopted
molecular determinants pathogenic leukocyte migration across blood nerve barrier chronic inflammatory demyelinating unknown specific disease modifying therapies also lacking connecting segment alternatively variant expressed microvascular endothelial cells sites inflammation vitro situ leukocyte alpha integrin also known implicated pathogenic leukocyte trafficking multiple sclerosis inflammatory bowel disease sought determine role patient leukocyte trafficking across vitro severe chronic demyelinating vivo using representative spontaneous murine model peripheral blood mononuclear leukocytes untreated patients independently cytokine treated flow dependent vitro model system time digital video microscopy performed visualize quantify leukocyte trafficking comparing peptide blockade relevant controls fifty week old female deficient non obese diabetic mice spontaneous autoimmune peripheral treated daily peptide days via intraperitoneal injection appropriate controls measures disease severity motor nerve electrophysiology assessments histopathological quantification inflammation morphometric assessment demyelination performed determine vivo efficacy biological relevance evaluated immunohistochemical detection affected patient nerve biopsies peptide maximally inhibited leukocyte trafficking human vitro peptide treatment resulted significant improvements disease severity motor electrophysiological parameters demyelination histological measures inflammatory demyelination demonstrating expression leukocytes seen within patient nerve biopsies taken together results imply role pathogenic leukocyte trafficking providing potential target therapeutic modulation elsevier inc rights reserved
feature selection significant task data mining machine learning applications eliminates irrelevant redundant features improves learning performance many real world applications collecting labeled data difficult abundant data easily accessible motivates researchers develop semi supervised feature selection methods use labeled data evaluate feature relevance however till date comprehensive survey covering semi supervised feature selection methods paper semi supervised feature selection methods fully investigated two methods presented based two different perspectives represent hierarchical structure semi supervised feature selection methods first perspective based basic taxonomy feature selection methods second one based taxonomy semi supervised learning methods survey helpful researcher obtain deep background semi supervised feature selection methods choose proper semi supervised feature selection method based hierarchical structure
realistic rendering natural scenes captured digital cameras ultimate goal image processing recent years high dynamic range imaging received increasing attention producing high quality images multi exposure image fusion one popular methods achieve like image without tone mapping however existing fusion methods result serious color distortions due inappropriate image attribute selection paper propose multi exposure image fusion method based human visual perception overall image quality index local saturation adopt local saturation enhance fusion quality multi exposure images achieve natural color reproduction experimental results show proposed method successfully enhance image quality achieve realistic rendering natural scenes
paper examines evidence explained within framework neurocognitive model brain assesses certainty certainty refers low level interpretations ones environment high level conscious ones beliefs experiences model proposed explaining brain systems responsible assigning certainty dysfunction contributing cause maintenance beliefs suggested arise combination perturbed striatal dopamine aberrant salience cognitive biases tendency jump conclusions evidence hypothesis matches role emotion stress trauma sociocultural factors forming modifying also considered understanding mechanisms involved forming maintaining important clinical implications interventions improve cognitive flexibility cognitive remediation therapy mindfulness training potentially attenuate neurocognitive processes
broadly speaking supervised machine learning computational task learning correlations variables annotated data training set using information create predictive model capable inferring annotations new data whose annotations known ageing complex process affects nearly animal species process studied several levels abstraction different organisms different objectives mind surprisingly diversity supervised machine learning algorithms applied answer biological questions reflects complexities underlying ageing processes studied many works using supervised machine learning study ageing process recently published timely review works discuss main findings weaknesses summary main findings reviewed papers link specific types dna repair ageing ageing related proteins tend highly connected seem play central role molecular pathways ageing longevity linked autophagy apoptosis nutrient receptor genes copper iron ion transport additionally several biomarkers ageing found machine learning despite interesting machine learning results also identified weakness current works topic one reviewed papers corroborated computational results machine learning algorithms wet lab experiments conclusion supervised machine learning contributed advance knowledge provided novel insights ageing yet future work greater emphasis validating predictions
glucose concentration human body significant indicative diabetes screening significant develop rapid sensitive methods glucose detection herein reduced graphene oxide synthesized via simple convenient hydrothermal method also morphologies compositions systematically characterized found possess intrinsic peroxidase like activity effectively catalyze oxidation presence hydrogen peroxide accompanied blue color change catalytic activity matched typical kinetics highly dependent reaction time incubation temperature concentration peroxidase like successfully applied detection glucose detection limit low respectively furthermore carbohydrates sucrose detection glucose detection platforms glucose developed present work confirmed possess intrinsic peroxidase like activity also showed great potential applications varieties simple robust easy make analytical approaches future elsevier rights reserved
context pediatric abusive head trauma defined injury skull intracranial contents child age due impact violent evidence acquisition traumatic death children younger year leading cause death due child abuse clinical presentation observed children depends type accompanying injuries history physical examination important diagnosing distinguishing conditions mimic baby syndrome accidental trauma cancer metabolic diseases others results progress research medical diagnosis remarkable development treatment strategies limited reasons urgent need develop effective treatment strategies able improve outcomes conclusions construction nationwide database supports clinical studies required future
functional gastrointestinal disorders diagnosed classified using rome criteria criteria change time new scientific data emerge rome released aim review main changes rome now called disorders gut brain interaction rome rather western culture focus new including age gender womens health intestinal microenvironment centrally mediated disorders new disorders included although truly fit new definition including opioid induced gastrointestinal opioid induced constipation also new based available evidence including reflux hypersensitivity centrally mediated abdominal pain syndrome using normative survey determine frequency normal bowel symptoms general population changes time frame diagnosis introduced irritable bowel syndrome ibs pain required discomfort eliminated non specific different meanings different languages pain now related bowel movements rather just improving bowel movements get worse bowel movement functional bowel disorders functional diarrhea functional constipation ibs predominant diarrhea ibs ibs predominant constipation ibs ibs mixed bowel habits considered continuum rather independent entities clinical applications diagnostic algorithms multidimensional clinical profile updated new rome iteration evidence based oriented clinical applications new evidence become available future updates expected
background women using veterans health administration emergency departments eds yet capacities meet needs women unknown objective assessed resources processes conditions specific common women veterans design subjects cross sectional questionnaire census main measures resources processes place obstetric sexual assault mental health care patient privacy features stratified characteristics key results eds completed questionnaire approximately nine ten eds reported examination tables within eds access dna probes eds reported access pregnancy testing fewer two eds reported review pelvic ultrasound images available one third reported emergent consultations available written transfer policies specific obstetric reported available fewer half eds eds reported emergency contraception however approximately half reported rho immunoglobulin available notes standing orders relevant conditions reported uncommon consistent policy eds reported obtaining care victims sexual assault transferring another institution eds reported access private medical mental health rooms resources processes found available eds encounters women beds located complex facilities metropolitan areas conclusions although eds resources processes needed delivering emergency care women veterans gaps exist studies non eds required comparison creative solutions needed ensure women presenting eds receive efficient timely consistently high quality care society general internal medicine
background myocardial native measurements likely influenced blood since blood variable longer compared myocardial degrade precision myocardial measurements precision improved correction amount correction optimal blood variables correct unknown hypothesized appropriate correction reduce standard deviation native myocardial methods consecutive patients referred known suspected heart disease split derivation cohort model construction age years male validation cohort assessing model performance age years male exclusion criteria included focal abnormalities modified look inversion recovery sequence used acquire maps maps used measure native myocardial blood multivariate linear regression correction model implemented using blood measurement correction model derivation cohort applied validation cohort assessed reduction variability test results blood mean mean correlated myocardial pearsons range derivation validation cohorts respectively suggesting myocardial measurements influenced blood mean myocardial native differ derivation validation cohorts respectively derivation cohort correction using blood mean mean yielded decrease myocardial model derivation cohort applied validation cohort reduction maintained reduction measurement variability leads reduction sample size detect difference native myocardial conclusions correcting native myocardial blood improves precision myocardial measurement similar consequently improve disease detection reduce sample size needs clinical research
propose short reliable instrument based pre existing items measuring three dimensions religion end means quest starting items originally included religious orientation scale ros religious life inventory performed four steps analyses involving three independent samples italian respondents total process progressive refinement using exploratory factor analyses investigation meaning items confirmatory factor analyses eventually selected items pre existing scales religious life orientation scale report initial evidence psychometric qualities proposed instrument analyze correspondence parent scales future research investigate properties scale respondents countries belonging
study examined developmental trajectory potential source resilience prosocial behaviors childrens peer victimization third sixth grade trajectories examined children females caucasian phase study early child care latent growth mixture modeling indicated three latent classes emerged labeled resilient risk normative follow analyses covariates supported presence classes resilient class particular interest study indicated high initial dramatically decreasing victimization coupled high stable prosocial behaviors year period findings suggest potential protective function engaging prosocial behaviors victims highlight need examine potential heterogeneity among victims elsevier inc rights reserved
male female different experience backgrounds main differences explains differences women likely rely personal connections qualified women routinely passed favor similarly qualified men gender transitions affect recruitment patterns men women gender lead recruitment less qualified women article attempts explain informal gendered selection norms change time using detailed data mexican since data provide evidence discrimination successful female need experience party experience male also find evidence traditional gender roles lead women follow different paths power transition implementation gender importance local experience increased discrimination female declined diverse group women entered data show women likely men rely personal connections get power
stealth technology great importance significance reducing radar cross section improving target aircraft absorber one important structures stealth technology however present investigations mainly focus narrow band multi band extend operation bandwidth graphene based absorber structure proposed paper proposed absorber periodic structure whose unit cell consists square circular graphene based ring surface impedance periodic structure optimized match impedance free space wide band adjusting electrostatic bias voltage operation band significantly extended using commercial software microwave performance proposed absorber studied simulated results show proposed absorber absorb electromagnetic waves ultra wideband ghz absorbing rate moreover proposed absorber insensitive polarization incident wave due symmetry structure also find absorber tuned work frequency range ghz fixed geometrical parameter equivalent circuit model ecm approach interference theory employed investigate physical mechanism proposed absorber according ecm analyze resonant characteristics square circular graphene rings owing existence two different graphene rings two resonant frequencies detected optimizing structure parameters graphene rings two resonant frequencies brought closer resulting increase operation band hand real part input impedance equivalent circuit reaches omega part close omega provides good matching free space leading high absorption rate according interference theory amplitudes phases direct reflection multiple reflections waves studied found destructive interference direct reflection multiple reflection makes absorber high performance ultra wideband results obtained ecm good agreement simulation ones
background working memory training shown offer therapeutic benefits patients attention deficit hyperactivity disorder adhd patients mild borderline intellectual disabilities however robust evidence transfer effects treatment benefits placebo training lacking owing nature double blind research designs rcts children received non specific coaching based actual training performance active coaching based individual training results clinical practice enhance efficacy furthermore clinical experience general treatment approach vulnerable children shown intensity duration often stressful study therefore investigated efficacy less intensive prolonged including active personalized coaching feedback reducing behavioral symptoms improving neurocognitive functioning academic achievements children neuropsychiatric disorders methods design double blind rct children age neuropsychiatric disorders adhd autism spectrum disorder asd two groups receive version home school weeks days week min day one group receive active personalized coaching feedback based actual individual performance training group receive general non personalized coaching receive personalized coaching feedback groups undergo neurocognitive assessment working memory executive functioning academic achievements training complete several questionnaires behavioral problems parenting style months follow discussion study add literature since role coaching studied also provide opportunities investigate alternative version large group vulnerable children evidence based treatments available ultimately allow mental health care professionals special education schools use type intervention children neuropsychiatric disorders
seasonal depression seriously quality life many patients improve condition propose bright light therapy system system potential relieve patients symptoms caused seasonal depression system designed formal model driven design methodology methodology enabled minimize systemic hazards like patients unhealthy dose light achieved controlling race conditions memory design time prove system specification free invariant violations together similarity specification model implementation code make confident implemented system reliable tool help patients seasonal depression
recent developments single cell opened new opportunities studying dynamic processes immunology high throughput unbiased manner starting mixture cells different stages developmental process unsupervised trajectory inference algorithms aim automatically reconstruct underlying developmental path cells following review break strategies used novel class methods organize components common framework highlighting several practical advantages disadvantages individual methods also give overview new insights methods already provided regarding gene regulation cell differentiation trajectory inference field still infancy propose several future developments ultimately lead global data driven way studying immune cell differentiation
recent research findings illustrated false memories induced laboratory beliefs events occurred study assessed whether quality peculiar false memory whether represents general characteristic memory end examined whether people induced stop memories true experiences participants observed performed simple actions later informed performed false memories actions implanted use fabricated evidence receiving misinformation participants rated belief memory performing actions actions also performed actions performed whereas misinformation substantially participants beliefs specific performed actions little effect endorsement remembering actions misinformation thus boosted proportion occasions participants rated memories stronger beliefs weakened correlation belief memory ratings thus study provides first experimental demonstration non believed memories true experiences discuss findings reference small literature concerning use socially communicated misinformation undermine event memories reference structure memory elsevier rights reserved
investigate associations bullying abuse pelvic floor symptoms pain sexual health characteristics women presenting multidisciplinary womens center retrospective review prospective database patients completed questions bullying abuse sexual health validated questionnaires including pelvic floor dysfunction inventory overactive bladder questionnaire oab visual analog scale vas pain statistical analyses included chi squared tests compared victims bullying abuse non victims three hundred eighty patients reviewed three hundred thirty eight data bullying abuse history reported victims bullying reported victims abuse women history bullying abuse increased overall pain scores compared without history either women history abuse bullying increased scores compared women abused difference sexually active sexual satisfaction groups patients history abuse bullying greatest percentage women history bullying abuse predict increased pelvic floor distress symptoms increased pain increased clinicians screen exposure bullying abuse order provide comprehensive resources address psychosocial issues
many animal toxins target molecules need controlled certain pathologies therefore toxins led formulation drugs presently used many drugs still development nevertheless collecting sufficient toxins original source limiting factor studying biological activities thus molecular biology techniques applied order obtain large amounts recombinant toxins escherichia coli however animal toxins difficult express system results insoluble unstable proteins solve issues toxins fused tags improve protein expression solubility stability among tags small ubiquitin related shown efficient removed protease however removing labor time consuming process enhance system show construction vector allows expression protein fused protease way expression able leave protein interest free ready purification strategy validated expression new phospholipase recombinant toxins showed good yield preserved biological activities indicating vector viable method produce proteins difficult express
single molecule measurements valuable tool revealing details enzyme mechanisms enabling observation behavior however approach often requires enzyme substrate process alter enzyme behavior apply microfluidic trapping device allow first time prolonged solution phase measurement single enzymes solution individual redox events observed single molecules blue nitrite reductase used extract microscopic kinetic parameters proposed catalytic cycle changes parameters function substrate concentration consistent random sequential substrate binding mechanism
study assessed likelihood referral liver transplantation assessment prospective cohort patients infected hiv hepatitis complications cirrhosis infected patients centres least one complication cirrhosis recorded either hepatocellular carcinoma identified cirrhosis hcc referred liver transplantation assessment even though referral recommended infected patients first episode
predictive nature digital soil mapping makes labour cost effective way facilitating soil surveys digital elevation model used generate terrain attributes used infer distribution soil associations relative topography two study areas free state province south africa considered slope aspect contour plan curvature topographic index topographic morphological unit used develop model predicting soil associations discriminant analysis employed develop model model trained data obtained validated data predicting soil form unsatisfactory prediction done soil associations soils grouped deep shallow valley bottom soils criteria closely related suitability field rainwater harvesting achieved acceptable improvement prediction accuracy analysis done using equal prior probability accuracy percentages found calibration cross validation areas suited field rainwater harvesting respectively prior probability set accordance sample frequency accuracy percentages improved respectively prediction accuracy percentage low equal prior probability markedly improved prior probability similar sample frequency results support validity statement predictive nature digital soil mapping makes labour cost effective way facilitating soil surveys
decline species richness altitude one obvious patterns ecology results combination ecological evolutionary mechanisms harsh high altitude environments effect altitude usually environmental variables related biodiversity studies using species richness along altitude gradients high altitude relatively numerous lakes ponds however due special features small size high isolation regional variability ponds proved different systems compared lakes high altitude species family often dominate communities thus serve ideal model study aquatic community changes along altitude gradient however due time consuming processing expertise needed identify species often excluded regular surveys present study sampled ponds altitude gradient special attention total taxa collected constituted group taxa present study ponds diverse pond supported taxa mean diversity taxa pond total richness decreased altitude richness showed weak negative response altitude proportion total diversity made decreased altitude opposite trend recorded proportion
although cognitive behavioral therapy cbt widely recognized preferred treatment psychiatric disorders less known application cbt substance use disorders particularly adolescence article discusses cbt substance use implemented treatment adolescent substance abuse article draws several cbt implement standalone treatment combination motivational enhancement therapies also reviewed several studies examined efficacy cbt finally implications discussed numerous starting resources provided help clinician implement cbt
since brown work simplest enzyme kinetics model contains three rate constants thoroughly explored many directions using equation measured quickly three rate constants derived temperature jump method transient state kinetics methods need complicated techniques previous paper math gave method measure rate constants require additional equipment needed measuring propose new one needs additional equipment either method based study points integral curves numerical results show new one much better previous one two aspects near end reaction new one gives accurate estimation quasi steady state reaction also gives good estimations previous one hence method advances estimation accuracy also choices measuring
county considered highly endemic area hepatitis virus hbv plasma derived vaccine used newborns area since cross sectional survey conducted evaluate long term effectiveness vaccine total participants born received series plasma derived ages months enrolled serological hbv markers detected compared previous survey data overall prevalence hepatitis surface antigen participants subjects received first dose within positive subjects received delayed first dose also positive subjects identified received first dose within whose anti prevalence increased yearly immunization anti rate vaccine effectiveness declined geometric mean concentration antibody anti positive participants declined immunization fewer participants anti levels data show protective efficacy plasma derived declined administration vaccine within birth important reduce risk hbv infection highly endemic area dose necessary anti levels fall age years furthermore studies immune memory induced plasma derived vaccine needed
serotonin implicated promoting self control regulation physiological homeostasis regulation caloric intake however remains unclear whether effects serotonin caloric intake reflect purely homeostatic mechanisms whether serotonin also modulates cognitive processes involved dietary decision making investigated effects acute dose serotonin inhibitor choices food items differed along taste health attributes compared placebo inhibitor twenty seven participants attended three sessions received single doses placebo double blind randomised cross design relative placebo increased choices healthy foods less healthy foods also increased emphasis health considerations decisions affect decision making relative placebo results support hypothesis serotonin influence food choice enhancing focus long term goals findings relevant understanding decisions food consumption also treating health conditions eating disorders obesity
recently shown mice exhibit depression like behavior short photoperiod suggested animal model investigating seasonal affective disorder sad study tested manipulations circadian clock melatonin treatment effectively modify depression like anxiety like behaviors brain serotonergic system mice short light dark daily melatonin treatments light offset significantly altered patterns mrna expression circadian clock genes clock within nuclei mostly increasing amplitude rhythms without inducing robust phase shifts melatonin treatments altered expression genes serotonergic neurotransmission dorsal serotonin contents amygdala importantly melatonin treatment reduced immobility forced swim test depression like behavior key mechanism melatonin induced antidepressant like effect previously proposed phase advance hypothesis circadian clock confirmed conditions experiment however findings modest adjustments amplitude phase transcriptional oscillators result melatonin treatments sufficient associate effects seen brain serotonergic system improvement depression like behavior study confirmed predictive validity mice useful model molecular analysis links clock brain serotonergic system greatly accelerate understanding pathogenesis sad search new treatments
following paper highlights enhancement promotion regions rural tourism plus green buildings importance kind sustainable competitive one providing ideas valuable suggestions natural environmental cultural assets landscape properly exploited rural tourism values also applies interest rural buildings landscape architecture rural tourism concerns health protection welfare expressed life air waters quality genuine food eco friendly facility rural landscape used source satisfaction green building means build aim ensuring peoples wellbeing regarded physical mental condition individuals health socio economic balance environmental protection play role ideal prototype rural tourism encourage practices making farm service sustainable environmental landscape context promoting creative activities keeping natural historical setting authors published elsevier open access article license
objective work comparatively study tissue associated pathology small field strains using experimental infection sheep bone marrow fifteen male free breed inoculated strain nervous tissue origin animals strain articular origin animals uninfected culture medium clinical polymerase chain reaction pcr evaluations performed periodically two infected group control animal days tissues analyzed gross evaluation immunohistochemistry cell markers lung morphometric evaluation tissue quantification pcr infected animals became positive either enzyme linked immunosorbent assay pcr group showing highest values consistently positive pcr reactions group showed representative lung lesions mild changes central nervous system cns joints group demonstrated intense arthritis interstitial pneumonia absence lesions cns copies tissues detected group experimental infection strains indicates strain virulent strain prone induce arthritis whereas strain likely reproduce host factors viral factors responsible final picture infections
gender critical social factor influencing children view world early childhood additionally early elementary years parents significant influence childs behaviors fields science study examined influence parent gender child gender grade childrens strategies solving science problems parents attitudes science behaviors parent child dyads solved hands science problems together informal setting examined child interview parent questionnaire used elicit information attitudes toward life science compared physical science quantitative qualitative analyses parent child interactions revealed differences amount offered boys versus girls additionally differences questioning behaviors parents function parent gender child gender furthermore parental interest various science topics differed along traditional gender roles whereas boys girls interested topics disciplines
prevalence child abuse higher families psychosocial vulnerabilities one parents experienced abuse neglect childhood widespread intervention approaches canada material support parenting skills programs show mixed results providing changes cycles examine clinical practice focused repetition trauma order explore topic paper objectives supported narrative review literature document child maltreatment identify clinical challenges parents develop critical analysis intervention programs commonly spread canada take account multifaceted vulnerabilities families innovative practice perspectives published elsevier masson sas rights reserved
new technologies underground works project run consortium industrial research development laboratories small medium enterprises organizations across countries europe ultimate goal enable change construction management maintenance aims developing fully automated system installed tunnel machine provides identification large obstacles foundations remains etc soil changes gravel rock
satellite remote sensing platforms collect measurements global scale within days provides unprecedented opportunity characterize understand spatio temporal variability environmental variables additional challenges making precise accurate measurements space essential validate satellite remote sensing datasets highly precise accurate ground based measurements focus article two sets measurements atmospheric column averaged carbon dioxide collected carbon mission target mode operation ground based data used validation total carbon column observing network current statistical modeling relationship less precise satellite data precise ground based data assumes linear regression measurement errors reside data data obtain consistent estimates regression coefficients critical determine error variance regression article rigorous statistical procedure presented obtaining error modeling spatial temporal dependence structure datasets numerical results analyzing data station corresponding target mode data orbit number illustrate procedure
study aimed test knowledge emergency contraception according age sexual initiation type school knowing someone already used emergency contraception influences methods use cross sectional study probabilistic sample students years age enrolled public private middle schools medium sized city southeast brazil data collected using self administered questionnaire structural equations model used data analysis considering age sexual initiation type school knowledge emergency contraception associated use knowing someone used method showed significant mean effect use emergency contraception peer group conversations emergency contraception appear greater influence use method knowledge economic status sexual experience
bacterial phosphate dehydrogenase gene introduced potato agrobacterium tumefaciens mediated transformation transgenic plants selected medium containing confirmed polymerase chain reaction pcr southern blotting pcr analyses selected transformants accumulated sugar alcohol found potato experiments designed testing salt tolerance revealed enhanced nacl tolerance transgenic lines vitro culture compared nacl shoot fresh weight plants reduced nacl conditions however condition shoot fresh weight transgenic plants reduced compared nacl treatment improved tolerance transgenic line attributed induction progressive accumulation roots shoots plants contrast vitro experiments content transgenic roots shoots increased nacl decreased slightly nacl respectively overall amount accumulated transgenic lines small act thus act however results demonstrated contribution osmotic adjustment roots shoots finally concluded expression transgenic potato plants significantly increase accumulation contributes enhanced tolerance nacl stress furthermore although enhanced tolerance resulted mainly action effect ruled
multiphase drives convenient high power high current applications allow reduction phase current given rated power phase voltage addition possess inherent fault tolerant capability due redundant structure therefore multiphase drives represent promising solution safety critical applications electrical ship propulsion railway traction hybrid electrical vehicles hev wind power generation electric engine electric aircraft applications moreover additional degrees freedom exploited integrated battery although literature reports many machine design solutions control techniques multiphase drives penetration multiphase solutions transportation energy production still limited reason paper contains brief overview multiphase solutions transportation energy production addition paper includes generic modeling approach multi three phase machines used multiphase drive treated modular independent three phase units experimental results provided reduced scale prototype twelve phase multiphase induction motor drive using control scheme based multi three phase approach
background objective study present month lifetime prevalence correlates comorbidity treatment disability dsm bipolar disorder methods nationally representative adult sample national epidemiologic survey alcohol related conditions iii results month lifetime dsm bipolar disorder differ men women bipolar disorder greater among native americans lower among asians pacific whites rates also lower among younger older individuals previously married currently married lower education income relative higher education income bipolar disorder strongly related borderline personality disorders adjusted odds ratios anxiety disorders substance use disorders overall among men women quality life lower among individuals bipolar disorder relative without disorder treatment rates among individuals bipolar disorder low total sample among men among women conclusions bipolar disorder continues common disabling highly comorbid disorder among men women contributing substantially low quality life burden disease society published elsevier ltd
durability building materials key parameter sustainable construction premature deterioration concrete structures occurs sewage water pipelines concrete waste water systems due microbial activity reducing bacteria bacteria prolong life time concrete structures concrete durability aggressive environment improved partial replacement cement several waste materials incorporation silica concrete composites positively influence important concrete characteristics water absorption capacity thus waste based contribute increased durability structures also minimization wastes using building industry addition saving raw materials cement production considered resource efficient materials thus green building materials paper presents results testing water absorption capacities concrete composites different compositions day exposure bacterial environment mixtures cement replaced blast proportions mixture hybrid cement used concrete specimens without cement replacement placed environment bacteria days experiments model laboratory conditions water absorption capacities measured according common test procedures experiments
paper studies design microwave external based impedance matching paper deal topology signal flow graph coupled biological tissue
electric motor influences surroundings magnetic fields influence matter certain cases hence reduction field intensity outside motor part motor design primary objective provide safety region humans reduce low frequency electromagnetic emission produce silent electrical machines propulsion military low magnetic fields required paper analyses particular case influence magnetic fields motor multi motor assembly several motors rotor position motor affected magnetic fields nearby motors finite element analysis mutual influence provided construction change suggested reduce position shift rotor due rotation rotors
development technologies nowadays moving speed computer graphics simulations augmented reality created just one many examples reality supplemented computer generated input case reality box full sand input elevation sensor detects micro relief forms computer estimation relief map projected sand forms changing lines changing project new accurate relief actually represents important conceptions ecology topographic mapping etc way children students main reason system part equipment laboratory included lessons games tool improving knowledge events floods drought fire especially gives opportunity making virtual rain areas depending relief watersheds paper detailed presentation working system proposals educational activities large age range children university students made order use augmented reality special instrument displaying events new ideas suggested consideration future improvement meet needs educational training disaster response children
rate limiting factor angiotensin blood pressure regulation system although exclusively produced kidney species synthesis secretion active enzyme confined almost exclusively dense core granules cells processed stored release via regulated pathway despite importance structural organization regulation granules within cells understood part due difficulty primary cells vitro lack appropriate cell lines isolation culture primary expressing cells suitable high speed high resolution live imaging using gradient based procedure cells transgenic mice coated glass proved optimal adhesion expressing cells facilitated live cell imaging plasma membrane primary cells using total internal reflection fluorescence microscopy obtain quantitative data intracellular function stained mixed populations red stimulated cells using analysis membrane proximal acidic granular dynamics behavior within expressing cells revealed existence two populations granular organelles distinct functional responses following stimulation application high resolution techniques imaging specialized kidney cells provides new opportunities investigating renal cell biology
paper year meteorological data observed taiwan studied investigate inherent correlation renewable resources data investigated time frequency space using wavelet analysis including wind speed global solar radiation air temperature wavelet transform time series related cross wavelet transform wavelet coherence phase angle obtained results show wavelet power spectra exhibit prominent oscillations annual half year periods three kinds meteorological data oscillations periods show regular pattern wind speed spectrum irregular two types data due climatic geographic factors whereas temperature regular form cross wavelet transform data pairs seen wind speed solar radiation anti phase correlation implying wind solar energy used complementary roles electricity generation region results wavelet analysis variation trend monthly mean meteorological data year period wavelet analysis robust tool oscillation characteristic study time series data elsevier ltd rights reserved
experience multiple poorer mental health due often triple minority status poor female women color present study examined whether identifying mexican culture dominant culture high ethnic identity identifying feminine masculine behavior gender role perceiving greater family social support predicted life satisfaction positive affect low socioeconomic status mexican mexican american women results indicated greater ethnic identity greater perceived family social support significantly predicted mexican mexican american womens life satisfaction greater ethnic identity greater feminine gender identity greater gender identity greater perceived family social support significant predictors positive affect furthermore expected social support family significant predictor life satisfaction positive affect implications results suggestions future research discussed
aims aim study verify suitable use candidate probiotics selected vitro tests importance vivo assays micro organisms probiotics alternative prophylactic treatments salmonella infection methods results thirty three lactic acid bacteria lab isolated assessed based main desirable functional vitro criteria based results strain chosen evaluate putative probiotic features mouse model salmonella infection daily doses days days salmonella challenge cfu per mouse led significant mouse health increasing weight loss worsening clinical symptoms time number deaths salmonella modulated cell mediated immune responses regulation gene expression proinflammatory cytokines ifn gamma tnf alpha small intestine conclusion usual criteria used vitro screening large number lab desirable probiotic functional properties however best candidate probiotic strain identified experimental disease mice significance impact study findings emphasize need prophylactic therapeutic effectiveness demonstrated vivo models make precise health claims
context previous injury strongest risk factor future injury sports proposed motor control changes movement limitation asymmetry associated injury pain part individuals movement strategy motor control fundamental body weight tasks reliably efficiently measured field objective determine whether motor control fundamental movement patterns pattern asymmetry relationship time loss injury course professional football design injury risk study setting american professional football facilities participants american professional football players intervention measure motor control body weight fundamental movement patterns functional movement screen scores obtained start training camp previously established cutoff score presence examined using relative risk determine relationship exists time loss injury main outcome measure time loss musculoskeletal injury defined time loss practice competition due musculoskeletal injury results players scored exhibited relative risk similarly players least asymmetry displayed relative risk combination scoring threshold exhibiting movement asymmetry highly specific injury specificity conclusion results study suggest fundamental movement patterns pattern asymmetry risk factors time loss injury professional football players
background although organizations comprehensive formal stress management programs approach likely helpful one specifically needs particular nursing unit aim mind process daily intensive care unit icu multidisciplinary operational developed operational use concepts traditional yet offered daily basis rather reserved major stressful events furthermore informal brief minutes multidisciplinary icu nurses icu social worker icu icu pharmacist purpose descriptive study determine perceptions relation implementation daily operational methods six months process requested fill anonymous voluntary survey questions simple straightforward close ended results potential respondents nurses nurse managers social worker pharmacist completed survey results revealed overwhelming majority felt daily operational provide effective unit based support system sense commitment others nearly respondents felt overall stress level icu decreased indicated operational daily continue conclusion daily informal multidisciplinary icu operational provides effective support system icu nurses modified model replicated non icu units
given graph perfect matching investigate parameter eta originally motivated computer graphics applications defined follows among edge weight assignments eta minimum ratio maximum weight perfect matching maximum weight general matching paper determine exact value eta rectangular grids cylindrical grids grids introduce several new techniques elsevier rights reserved
aim aim study quantify prevalence somatic pain paediatric emergency department methods conducted prospective observational study using patients admitted italian childrens hospital december february enrolled children aged turned pain patients parents asked fill questionnaire allow analysis patients medical history provide contact details follow divided enrolled patients four groups post traumatic pain organic pain functional pain somatic pain questionnaire used define pain characteristics generate impairment score results patients met inclusion criteria enrolled study suffered post traumatic pain organic pain functional pain somatic pain somatic pain patients pain longer missed school days suffered severe functional impairment conclusion study highlighted somatic pain significant contributor paediatric emergency room visits suspected diagnosed children reporting pain
third stem cell niche meeting supported novo foundation held year brought together selected participants different countries denmark diverse aspects embryonic adult stem cell biology discussed including respective ageing disease regeneration many presentations focused emerging technologies including single cell analysis vitro direct reprogramming summarize data presented exciting highly meeting speakers every session
work highly porous nanostructures synthesized via one versatile precursors first thermal polymerization carbon suppresses aggregation thermal decomposition formed carbon brings pores size nanostructures generating extremely large specific surface area due high specific surface area abundant exposed edge sites resultant porous nanostructures exhibited outstanding electrochemical hydrogen evolution activity aqueous solution onset potential current density low similar similar respectively superior previously reported based published elsevier
energy universal concept used across physical domains describe complex large scale industrial systems brief survey framework gives perspective energy domain system modelling supervision control traditionally modelling control problems approached adopting signal processing paradigm however approach becomes problematic considering non linear systems behavioural viewpoint incorporates energy basis modelling control considered viable solution since energy seen concept relationship euler equations state space representation lyapunov functions discussed connection control process supervision using theory coupled system energy balance also established show complex industrial systems comprising multiple energy domains modelled means single electric circuit application large scale thermo hydraulic system presented next simple non linear transmission impedance electric circuit used illustrate energy used describe system also serve basis system optimisation energy based framework proposed whereby energy used domain work analyse optimise large scale industrial systems
portions plants called used medicines contains great variety study using cultured cells showed production alpha alpha delta induced treatment methyl led cloning delta present study analyses genomic organization southern blotting delta synthase performed order examine genomic background delta plants genomic cloning sequencing revealed five types sequence putative delta sharing identity exon regions enzymes belonged class iii seven exons six furthermore southern blotting revealed least five copies delta synthase existed hybridization digested dna probes made delta synthase cdna fragment resulted different patterns two species possible identify species restriction fragment length polymorphism analyses delta synthase cdna probes
recent years great deal effort made create devices meta materials among devices perfect modulators highly desired system communication remote sensing imaging variety potential applications including thermal detector stealth technology phase imaging high speed modulators allow actively control spatial transmission reflection incident wave key components advanced communication system presentation firstly introduce basic structure work principle devices report recent progress design fabrication measurement quite new devices close presentation demonstrate application devices communication system
alzheimers disease multifactorial disease wide clinical amyloid precursor protein app accumulation beta amyloid beta tau proteins important hallmarks identification early critically important discovery early diagnosis markers decreased brain metabolism one earliest clinical symptoms indicate mitochondrial dysfunction brain performed first comprehensive study integrating synaptic non synaptic mitochondrial proteome analysis two dimensional differential gel electrophoresis mass spectrometry correlation beta progression app mice months age identified changes mitochondrial proteins reflect progressive effect app beta accumulation mitochondrial processes significantly affected proteins play role mitochondrial electron transport chain acid cycle oxidative stress apoptosis altered expression levels showed parallel changes different age groups confirmed also western blot common regulator analysis suggests regulatory role tumor necrosis factor tnf beta mediated mitochondrial protein changes results accordance previous postmortem human brain proteomic studies case many proteins results open new path research aiming early mitochondrial molecular mechanisms beta accumulation prodromal stage human
study aimed polish wastewater effluent activated treatment system nitrogen removal packed bed nitrogen removal via simultaneous partial process investigated different hydraulic retention times results show effluent ammonia nitrate nitrogen concentrations approached low total nitrogen removal efficiency decreased average low nitrogen removal efficiency due presence incomplete degradation organic nitrogen shorter analysis using quantitative real time polymerase chain reaction ratio ammonia bacteria domain changed limited range continuous operation meanwhile nitrite bacteria increased gradually reduced bacteria accounting microbial dominated sum inorganic form nitrogen typical wastewater plant effluent efficiently via process elsevier ltd rights reserved
chinese mapping satellite launched provide wide remote sensing images together acquired sensor pan however limited precision caused particular configuration pan reduces geometric quality images application letter propose new image space approach based differential optimal estimation filter pan images describe detail validate correctness advantages method experiments run several sets matching points different characteristics images different geographic conditions results show images seamless visual effect level precision obtained
objectives right ventricular cardiomyopathy caused mutation fully autosomal dominant cause sudden cardiac death prophylactic implantable therapy significantly reduces mortality returning lethal cardiac rhythms normal qualitative study assessed psychological implantable recipients mutation negative siblings design qualitative interview study participants twenty one individuals nine mutation positive eight mutation negative four families completed semi structured interviews results theoretical assumptions data made inductive sub coding accomplished constant comparison method cohesive themes across interviews determined family history sudden cardiac death appropriate implantable therapy family members average length time implantable years major themes included acceptance acceptance psychological effects emotional psychological functioning broader family unit relationships practical concerns travel loss driving effects implantable discharge affected family members regardless mutation status conclusions despite survival advantage implantable therapy intervention carries psychological practical burdens family members appear time move towards integrating psychology services cardiac genetics clinic extended family provide benefit
orbitofrontal cortex involved emotional processing orbitofrontal abnormalities often observed various affective disorders thus chronic dysfunction cause symptoms affective disorders anxiety depression impulsivity previous studies investigated effect orbitofrontal dysfunction anxiety like behavior impulsive aggression rodents results inconsistent possibly reflecting different methods inactivation studies used either lesion affect brain regions transient inactivation whose effect restored time reflect effects chronic dysfunction addition study effect orbitofrontal inactivation depression like behavior rodents therefore present study examined whether chronic inactivation continuous infusion receptor agonist causes behavioral abnormalities rats infusion ventral lateral part following week inactivation animals showed increase anxiety like behavior open field test light dark test impulsive aggression also augmented chronically animals showed increased frequency behavior induced electric foot shock hand chronic inactivation reduced depression like behavior evaluated forced swim test additionally cause significant change secretion response restraint stress data suggest orbitofrontal neural activity involved regulation anxiety depression like behaviors impulsive aggression rodents
objective determine effect biological mesh closure wound healing resection background wound complications frequently occur preoperative radiotherapy rectal cancer cohort studies suggested biological mesh closure pelvic floor improves wound healing methods patients randomly assigned primary closure standard arm biological mesh closure intervention arm non cross linked porcine dermal mesh pelvic floor intervention arm followed layered closure subcutaneous fat skin similar control intervention outcome randomization patient wound primary endpoint rate wound healing defined wound score less days postoperatively patients followed year results total patients randomly assigned primary closure biological mesh closure wound healing rate days primary closure significantly differ biological mesh closure relative risk confidence interval freedom year versus respectively conclusions wound healing preoperative radiotherapy rectal cancer improved using biological mesh significantly lower year rate biological mesh closure promising secondary finding needs longer follow determine clinical relevance
genetics genomics increasingly relevant primary healthcare training unavailable many practitioners education accessed practitioners without cost travel essential project formed provide effective education genetics primary healthcare europe improve patient care partners include patient representatives specialists genetics primary care six countries report progress challenges involved creating european online educational program genetics
currently modeled univariate retrieval process memory probes provoke conscious awareness contextual details earlier target presentations however conception explain manipulations increase recognition experiments suppress false memory false memory experiments whereas others increase false memory contrasting effects explained bivariate memory probes provoke conscious awareness target items per separately awareness contextual details false memory suppressed former increased latter interestingly conceptions time different segments memory literature independent support dual hypothesis provided surprising effects predicts release rejection false persistence negative relations false alarm rates target remember know judgments without remembering implemented hypothesis bivariate models differ degree treated discrete graded process pure multinomial model pure signal detection model mixed multinomial signal detection model models applied large corpus recognition data fits satisfactory processes present unsatisfactory either factor analyses models parameter spaces showed target context never loaded common factor models process loci effects important experimental manipulations thus variety results consistent bivariate
open access supported national science foundation provides powerful versatile platform delivering computational resources support implementation integrated computational materials engineering solutions associated educational efforts provides free cloud scientific computing users access simulation tools research education using web without need install software access local computing resources tools friendly fully interactive graphical user interfaces meaningful default values output numerical data visualizations extensive support material provides accessible pathway towards advanced materials simulations back end computational resources include high performance computing clusters enable research quality simulation platform researchers educators two distinct ways using existing tools creating publishing new customized tools existing tools currently used introduce simulations courses variety areas electronic structures diffusion kinetics mechanics materials tools created installing available open source code building custom graphical user interfaces using toolkit rapid application infrastructure http integrated similar manner instructors install simulation tools using easily tools meet learning objectives paper introduces existing tools additional resources materials science education procedure publishing new simulation tools
background aim study evaluate efficiency adverse effects impact empirical antifungal therapy hematological malignancy patients china material methods patients neutropenia hematological malignancy randomly divided empirical group group antifungal treatment initiated patient status confirmed clinical manifestation imaging diagnosis beta testing test treatment ended weeks later patient recovered neutropenia used first line medicine patients received intravenous administration every initiating dose dose reduced results overall survival rate empirical group group respectively significant difference observed chi however occurrence rate invasive fungal disease group empirical group moreover mortality rate due empirical group group respectively average duration cost antifungal therapy days respectively lower empirical therapy however significant differences observed incidence adverse effects hospital stay groups conclusions antifungal therapy patients hematological malignancy demonstrated similar survival rate empirical therapy economically favorable chinese population
transition sustainable economy inevitable population consumption continue grow ecosystems decline result increased business activity resources limit survival businesses much dependent ability adapt transition business model addresses important sustainability climate change energy fuel material resource scarcity water scarcity population growth wealth food security ecosystem decline research identifies important construction industry sector examines level australian construction companies responding also identifies value drivers behind content analysis recommendations provided construction companies develop resilience remain competitive future paper interest construction management sustainability practitioners
evaluate concurrent validity pediatric global health measure child report parent proxy versions surveys administered via home computer two separate occasions december august september convenience sample children years old parents participated national internet panel data analysis included evaluations differences scores groups defined clinical characteristics access health care associations pediatric measures correlations two health related quality life instruments scores lower children chronic conditions hispanic ethnicity low socioeconomic status barriers accessing health care showed excellent convergent discriminant validity pediatric measures physical mental social health strongly correlated assesses positive health moderately correlated assesses problems childs health measures global health summarizing childs physical mental social health single score properties make useful clinical population health research tool applications require efficient precise valid summary measure childrens self reported health status future research prospectively evaluate capacity detect change results alterations clinical status transformations healthcare delivery system childrens health development
brief presents ultra low power low noise coupled instrumentation amplifier suitable neural recording applications active high pass filter embedded ripple reduction loop suppress residual noise capacitor size multiple employed reduce residual output ripple due servo loop using amplifier proposed achieve high pass corner using chip capacitor complete implemented standard cmos process occupies area including consumes supply achieving noise efficiency factor compares favorably state art
paper presents new circuit circuit built around current feedback operational amplifier exploits nonlinear transfer characteristic operational transconductance amplifier provide continuous change contrast many available provide binary levels moreover low impedance input suitable current driving rather voltage driving functionality proposed confirmed implementing known less circuit experimentally obtained results included elsevier gmbh rights reserved
background aim study evaluate feasibility effects based information self help program therapist contact parents children adolescents program aimed reduce parents symptoms general posttraumatic stress methods participants parents children treated either two specialized swedish burn centers sixty two parents included two randomized controlled trial six week intervention group wait list control group including pre post assessment month follow intervention contained exercises assignments intervention group received weekly written feedback therapist main outcome stress post traumatic stress general stress parental stress results program beneficial effect posttraumatic stress short term affect general stress parental stress parents rated program informative meaningful thought time consuming conclusion program potential support parents children intervention easily accessible cost effective implemented care rehabilitation author published elsevier ltd
paper presents study leading new acute toxicity test embryonic juvenile organisms great pond acid nitric acid ammonium used laboratory experiments exposure time tests conducted toxicity substances classified according different scales tests sensitivity compared commonly used assessment toxicity impact supported microscopic observations method used parametric statistical procedure estimate associated confidence interval study showed early developmental stages sensitive making possible detect even low levels mentioned water highest toxicity shown ammonium values respectively embryos juvenile forms lowest shown nitric acid ions values respectively embryos juvenile forms highly cost effective due simple efficient breeding small size organisms population compared relatively low concentrations caused lethal effect embryonic juvenile organisms great pond owing common occurrence sensitivity early developmental forms valuable new tool freshwater environment
background research roles play fibrotic process attracted great attention early stage pancreatic effectively regulate pancreatic cells activation crucial treatment chronic pancreatic fibrosis methods microarray data chronic retrieved gene expression geo repository analyzed using bioinformatic methods diagram mirna mrna network constructed addition activated rat transfected small interfering rna sirna targeting expression mir mir examined pcr expression interleukin signal transducer family member alpha smooth muscle actin alpha sma proteins examined western blot expression alpha sma examined immunofluorescence staining results based results bioinformatic analysis mirna mrna network established number putative pairs regulating activation identified including mir mir expression downregulated relative expression level expression mir significantly elevated relative expression level expression mir markedly reduced relative expression level expression decreased relative expression level whereas expression displayed significant change additionally expression sma dramatically reduced relative expression level immunofluorescence analysis confirmed alpha sma expression decreased cells conclusion activation chronic existence interactions pancreatic fibrosis demonstrated regulation mir axis serve new gene therapy strategy treatment chronic reversal pancreatic fibrosis published elsevier rights reserved
medical image segmentation requires consensus ground truth derived multiple expert annotations novel approach proposed obtains consensus experts using graph semi supervised learning popular approaches use iterative expectation maximization estimate final annotation quantify performance techniques pose risk getting trapped local propose self consistency score quantify consistency using low level image features used predict missing annotations considering global features local image consistency score also serves penalty cost second order markov random field cost function optimized using graph derive final consensus label graph cut obtains global maximum without iterative procedure experimental results synthetic images real data crohns disease patients retinal images show final segmentation accurate consistent competing methods
hiv hiv closely related differences pathogenicity geographic distribution hiv infection associated slower disease progression transmission longer latency period low undetectable viral loads reduced likelihood progression aids compared hiv investigation analyzed hiv genes genomes compared hiv belonging various subtypes comparative analysis effective number nine genes two viruses revealed gene hiv higher value compared hiv reflecting lower levels expression hiv lower levels protein particularly early stages infection result lower viral load lower viral set point delayed progression disease hiv infected individuals compared hiv infected subjects furthermore composition regulatory genes hiv suggesting firm effort viruses adapt evolutionary survival hypothesize differential codon usage one possible factors contribute diminished pathogenicity hiv host compared hiv
article highlights significant health impact falls among older adults emphasis placed vital role pharmacist regardless practice setting assessing reducing falls risk growing population addition importance stepwise comprehensive approach falls assessment pharmacists collaboration clinicians elucidated
common severe antipsychotic induced adverse drug reaction meta analysis randomized controlled trials systematically examined efficacy safety adjunctive antipsychotic related schizophrenia patients two independent investigators searched extracted synthesized data weighted mean differences risk ratios confidence intervals calculated using random effect model four randomized controlled trials comparing adjunctive control groups lasting weeks treatment included meta analysis group significantly lower serum prolactin level endpoint four randomized controlled trials weighted mean difference confidence interval moderate quality based grading recommendations assessment development evaluation system patients menstrual disturbances rate group control group adverse drug reactions cause discontinuation three randomized controlled trials risk ratio confidence interval similar two groups adjunctive appears effective safe reducing antipsychotic induced prolactin related symptoms schizophrenia patients higher quality randomized controlled trials large sample size warranted confirm findings
typing classification escherichia coli coli according cell wall components like routinely done given presence known antigens process complex authors present proof concept planar array ten clinically relevant coli associated high risk diarrhea humans examined assigned specific populations differentiated size fluorescence color image processing data analysis conducted microscopic interpretation platform homogenous coating demonstrated intra population ranges inter population typical limits range significantly elevated fluorescence signals revealed coli certain bound specifically matching perception method represents viable diagnostic tool automated multiplex coli enables simultaneous high throughput screening different antigens simple staining binding protocol
understanding hydraulic system one learning objectives manufacturing engineering studies generally knowledge hydraulic system components learned existence conventional tutorial considered help understanding materials enough ability give clear illustration component system working paper aims look far custom made hydraulic system tutorial transparent flow concept improve competence students understanding work hydraulic system tutorial hydraulic system designed theme material handling using robotic arm dual acting cylinder actuator support movement arm components fluid including valves pumps actuators made transparent material visible colored fluid whole system component equipped label containing name symbol fluid flow direction tutorial operated manually designed easily based verification using questionnaire technology acceptance model students obtained value indicates tutorial quite acceptable based implementation test comparing difference value pretest posttest students using learning method students using tutorial learning method found significant differences indicate using tutorial better learning method authors published elsevier
psoriasis complex inflammatory disease occurs genetically susceptible individuals presents development plaques skin pathway play pivotal role pathogenesis psoriasis thus become targets recent biologic drug development human monoclonal antibody developed target block actions recently approved use first line systemic therapy patient moderate severe psoriasis studied first psoriasis diseases phase iii clinical trials demonstrated effectiveness treatment moderate severe plaque psoriasis demonstrated superiority comparable biologics market including tumor necrosis factor inhibitor etanercept also shown superiority relatively recent biologic introduced treatment psoriasis besides demonstrating better efficacy compared etanercept also demonstrated greater impact quality life patients comparable safety profile shows great promise tremendous impact treatment plaque psoriasis based ability produce similar better clinical outcomes biologic medications
present study first report providing evidence physiological role truncated form mrna cap binding protein eukaryotic initiation factor initial observation mediates mrna cap function complex composed occurs two forms porcine endometrial tissue strictly temporally restricted fashion ubiquitous prototypical kda form found ovariectomized cyclic animals new stable kda variant however predominant early pregnancy time implantation northern blotting cdna sequence analysis vitro protease assays showed kda form belong new class proteins represents processed variant lacking amino acids terminus steroid indicated progesterone combination beta induced formation kda modified cell free translation systems mimicking situation revealed besides also truncated poly binding protein kda form reduced function binding protein truncated lacked binding site thus suggest truncated provides alternative regulation mechanism altered dynamic binding conditions together impaired interaction modified translational initiation particularly regulate protein synthesis attachment time implantation
use absolute pretreatment apparent diffusion coefficients adc derived diffusion weighted imaging predict response repetitive liver metastases colorectal carcinoma months start treatment fifty five metastases patients examined prior treatment month initial treatment performed week intervals response evaluated months start therapy metastases showing decrease axial diameter classified responding lesions one month initial seven lesions showed early response significant difference absolute pretreatment adc values responding non responding lesions three months initial metastases showed response significant difference absolute pretreatment adc values lesions showing response median response median pretreatment adc showed fair diagnostic value predict response auc lesions showing response months also revealed significant increase adc measurements treatment one month initial applying increase adc response months initial predicted sensitivity specificity respectively auc furthermore strong significant correlation percentage change size third percentage change adc patients adc measurements potential biomarkers assessing response
paper presents unsupervised approach feature binary coding efficient semantic image retrieval although majority existing methods aim preserve neighborhood structures feature space semantically similar images always neighbors rather distributed non linear low dimensional moreover images rarely alone internet often text data tags attributes tend carry rich semantic information images basis observations approach presented paper aims learning binary codes semantic image retrieval using multimodal information sources preserving essential low dimensional structures data distributions space specifically finding low dimensional structures data using unsupervised sparse coding technique approach set linear projections binary coding solving optimization problem designed jointly preserve extracted data structures multimodal data correlations images texts space much possible show joint optimization problem readily transformed generalized efficiently solved extensive experiments demonstrate method yields significant performance gains several existing methods
purpose review provision adequate nutrients gut essential survival essential behaviors linked proper ingestion digestion food recently new neural connection reported sensory cells gut epithelium nervous system mediates signals gut brain recent findings review describes gut environment signals brain brain influences gut summary gut brain connection provides pathway body handles food
aim study analyze influence nucleotide transition position mcp gene related susceptibility developing two hundred twenty three consecutive patients according criteria included healthy subjects used controls mcp polymorphism present patients healthy subjects associations respectively patients mcp gene polymorphism confers susceptibility developing
presented project based learning laboratory approach upper division environmental chemistry quantitative analysis course work combined laboratory class environmental chemistry students developed method based published epa methods extraction environmental degradation products extraction quantitation using gas chromatography mass spectrometry derived procedures students spent semester performing analyses detect drift san valley california mountain range epa methods used allow multitude research level questions answered within similar course specific question appropriate student interest regional environmental issues pedagogical approach provided numerous teaching moments regarding pitfalls research low level quantitation environmental samples development opportunities student teamwork skills individual focused specific aspect project throughout semester
paper model single photon amplification based cluster state quantum computation proposed probability amplitudes deteriorated favor one photon component define amplifiers gain unlike quantum amplifiers probabilistic success whole process depend successful detection signal instead whole procedure rely upon single measurement simpler compared two interaction gate quantum amplifiers proposed model used propagation losses long distance quantum communication networks
background transforming growth factor beta tgf beta gene variants extensively studied various human diseases example tgf beta polymorphisms associated fibrosis data remained controversial aim meta analysis assess association tgf beta polymorphisms methods comprehensive literature search conducted searching pubmed embase chinese biomedical database chinese database end april eleven publications studies included meta analysis covering total patients controls study quality assessed heterogeneity publication bias measured statistical analyses performed using version college station usa software results data showed significant associations tgf beta polymorphism risk development odds ratio confidence interval tgf beta polymorphism risk addition subgroup analysis ethnicity versus types indicated significant association among asian populations coal workers caucasian populations contrast significant association exhibited tgf beta polymorphism risk conclusion polymorphisms tgf beta associated increased risk
family structures attitudes towards families sex parent cross race families appear becoming favorable despite favorable attitudes propose explicitly implicitly people view families less family like traditional heterosexual race families also propose people hold behavior traditional families higher standards study participants explicitly rated traditional family photos less family like less study using reaction time measure participants took longer correctly categorize traditional families family category suggesting implicit level people greater difficulty recognizing families family studies ambiguous positive negative behavior licensed harsh evaluations affect evaluations traditional learning positive family behavior despite survey data suggest peoples views families becoming favorable evidence indicates people nonetheless prejudice certain family structures beyond documenting two biases families work highlights need prejudice researchers examine meaningful levels social identity family units intermediate individuals broad social classes
type magnetic synthesized simple method used novel adsorbent selective enrichment effective isolation uniform magnetic affinity narrow particle size distribution displayed saturation magnetization value comprehensively possible formation mechanism sources dual precursors elucidated comparison nanoparticles respectively either source single precursor suggested spherical sheet nanostructures achieved via secondary probe exhibited excellent aqueous solution rapid magnetic separation within good importantly highly selective strong coordination interaction metal ions phosphate groups high specificity demonstrated effectively mixture beta bovine serum albumin high content non embodied enrichment non fat milk human serum consequently prepared affinity materials expected possess great potential research
efficiency mechanism electron energy transfer events occurring natural synthetic donor acceptor systems depend distance relative orientation nature surrounding media fundamental knowledge gained model studies key building efficient energy harvesting devices faster charge separation slower charge recombination donor acceptor systems often sought continued effort build donor acceptor systems using near present study report ground excited state charge transfer newly synthesized directly linked featuring donor entities synthesized using multi step synthetic procedure revealed strong charge transfer interactions ground state involving donor entities near emitting acted electron acceptor along whereas entities acted electron donors revealed charge separation leading center dot center dot center dot center dot charge separated states transient absorption spectral studies polar solvent media charge separated states excited state prior returning ground state
paper presents efficient robust implementation rail rail input stage transconductance control tailored low noise operational amplifiers based differential pairs biased sub threshold region proposed control circuit design indeed based transistors ratio allows efficient control scaled currents dimensions architecture guarantees nearly constant performance terms bandwidth power consumption whole common mode input range power area efficient way achievable precision transconductance control also analyzed transistor equations deviation predicted simple analytical model suggests also strategy minimization error proper tuning prototype input output rail rail operational amplifier fabricated standard cmos technology confirming validity control loop amplifier consumes supply open loop gain gain bandwidth product mhz
introduction impulsivity personality trait related control behaviour emotions found different psychopathological alterations including referred eating behaviour objective aim study analyse relationship among influence aesthetic body shape model eating behaviour risk specific disorders body mass index impulsivity method total males included study mean age height weight assessed order obtain body mass index participants fulfilled following questionnaires impulsivity scale bis questionnaire influences body shape model males eating attitudes test results respect possible cases eating disorders found scores items bis correlated significantly eat scores overweight participants showed higher level impulsivity eat scores cut point test conclusions assessment impulsivity psychological point view preventive tool regards disordered eating behaviours patients eating disorders overweight obesity assessment relevant aspect order improve approach
background congenital hypothyroidism one major causes physical mental disabilities preventable study aimed investigate physical growth evaluate effectiveness performed therapeutic interventions serum tsh levels children city methods retrospective cohort study performed neonates born years growth pattern height weight head circumference first five years children effectiveness performed therapeutic interventions serum tsh levels evaluated collected data analyzed using version spss software results pattern height weight head circumference girls comparable growth pattern healthy individuals pattern height weight growth boys gradually became similar growth pattern healthy boys however decline head circumference growth trend six months age also revealed therapeutic interventions appropriate effect normalization serum tsh levels growth pattern children treatment conclusions patients growth children reached normal desirable range
chronic myeloproliferative neoplasms mpn comprise spectrum clonal neoplastic disorders characterized differentiated cells myeloid lineage common genetic basis bcr negative mpn disorders elucidated identification mutation majority mpn patients discovery dramatic impact diagnosis treatment mpn testing mutations now included world health organization criteria diagnosis mpn oral kinase inhibitor ruxolitinib became first food drug administration fda approved drug treatment myelofibrosis drug now also approved europe canada
consideration paper lattice system symbolic computation lax pair conservation laws derived integrable lattice hierarchy fold darboux transformation constructed system furthermore soliton solutions terms determinant generated resulting fold structures one two three soliton solutions shown graphically interactions among two three solitons discussed figures plotted
describe measuring transducer electrical conductivity liquids used laboratory conditions also study ocean processes natural conditions transducer represented form separate unit laboratory investigations used part deep water hydraulic probe example different processes flows laboratory fluid mechanics shown small scale transducer high speed high spatial resolution
central carbon metabolism glycolysis phosphate pathway acid cycle plays essential role supply biosynthetic precursors energy central carbon metabolism changes varying growth rates vitro cultivation rapidly proliferating mammalian cells cancer cells continuous cell lines recombinant protein production remains elusive based relationships growth rate activity seven key enzymes six cell clones work reports finding important metabolic characteristic rapidly proliferating chinese ovary cells key enzymatic activity involved cycle responsible supply energy became elevated growth rate exhibited increases activity key enzymes metabolic pathways glycolysis responsible supply biosynthetic precursors tended rapidly proliferating cells still depended predominantly cycle rather aerobic glycolysis energetic demands meanwhile growth limiting resource likely biosynthetic substrates rather energy provision addition multifaceted role glucose phosphate confirmed based significant correlation activity percentage phase cells international union biochemistry molecular biology inc
paper presents new infrastructure creating specialized databases database management systems principles infrastructure formulated based analysis various nosql solutions main features proposed approach flexible system type definitions allows one create data structures based different paradigms different forms supporting structured data mapping onto file system experiments carried implement graphs relational tables name tables object relational mappings proposed approach allows one solve certain problems developing new technologies working big data
background systemic lupus erythematosus sle antibody syndrome autoimmune diseases affect women childbearing age maternal igg antibodies cross placenta pregnancy theoretically reach fetal brain studies showed increased number learning disabilities children objectives evaluate long term neurodevelopmental outcome children median age years born mothers sle carrying positive igg third trimester pregnancy methods children checked neurological physical exam intellectual cognitive functioning scale corrected age submitted mothers child behavior checklist set questions created pediatric results children neurological physical exam intelligence levels found normal cognitive impairment cognitive profile found children respectively learning disabilities diagnosed children school age children born mothers triple positivity history epilepsy shown four children conclusions children born women sle need long term follow focusing order detect correct alteration early possible
development science technology progress electronic information technology accepted public network information internet plus also become hot topic campus network become standard configuration daily life study application computer mobile phone also extensive life gradually network today network security issues attention society become one main existing problems campus network campus network faces problem network security becoming serious effectively protect network security problem become key problem set anti virus software strengthen identity authentication data encryption effective protection measures paper present safety hazards protective measures campus network analyzed
paper focus heavy stochastic signals generated continuous time autoregressive car models excited infinite variance alpha stable processes goal estimate parameters continuous time model autoregressive coefficients distribution parameters related excitation process alpha stable car process alpha based state space representation likewise investigate closed form expressions parameters equivalent model discrete time setting via regular samples process analyze estimator based monte carlo simulations illustrate estimator consistency desired values sampling frequency sample size tend infinity also apply proposed method two types real world data financial ground data evaluate performance real environments elsevier inc rights reserved
construction projects critical path method mainly used project scheduling planning past main objective find critical activities schedule project way project minimized resource allocation project scheduling problem one popular issues among construction management researchers past decades resource problem real world also important considered planning project side since two objectives opposite goals projects considering objectives simultaneously always challenging problem paper try solve problems time purpose two new metaheuristic algorithms called body optimization charged system search utilized two case examples solved show applicability performance considered algorithms
introduction seldom cutaneous present lasting active lesion known non healing form non functional type helper cells assumed important factor outcome disease present study aims assess molecular defects potentially contribute impairment methods analysis prospective observational study implemented among five groups first second groups comprise patients non healing healing forms respectively third group consists recovered participants result participants never lived endemic areas comprise fourth group fifth group comprises participants living areas although none aim recruit cases participants groups skin test performed assess vivo immunity infection cytokine profile interleukin interferon ifn motif chemokine ligand isolated peripheral blood mononuclear cells pbmcs evaluated elisa real time pcr determine motif chemokine receptor gene expression expression assessed flow cytometry furthermore mutation analysis performed discussion anticipated outcome current study identify mutations lead persistent lesions furthermore expected results reveal association pro inflammatory cytokines ifn expression ethics dissemination study approved local ethical committee final results disseminated peer reviewed journals scientific
paper first analyzed course setting programming computer major discussed problems exist computer programming course put forward course integration scheme according actual situation thinking teaching reform improve quality program design course teaching students innovation ability
mothers immune system adapt pregnancy accepting semi allograft fetus preventing harmful effects developing child aberrations maternal immune adaptation result disease mother liver injury five pregnancy associated liver disorders described far however little known concerning immune alterations promoting respective disease liver disorders pre elevated liver enzymes low platelet count acute fatty liver pregnancy hand pre existing autoimmune liver injury mother affected pregnancy review intends summarize current knowledge linking maternal immunology liver inflammation special emphasis novel potential biomarkers
objective goal examine association violence media expression seriously violent behavior among older children teenagers national sample methods growing media survey national online survey youths conducted august september participants year old youths used internet least past months main outcome measure self reported seriously violent behavior including someone assault sexual assault results five percent youths reported engaging seriously violent behavior past months thirty eight percent reported exposure violence online exposures violence media online line associated significantly elevated odds concurrently reporting seriously violent behavior compared otherwise similar youths indicated many web sites visited depicted real people engaged violent behavior significantly likely report seriously violent behavior adjustment underlying differences youth characteristics respondents alcohol use propensity respond stimuli anger peers parental monitoring exposures violence community also associated significantly increased odds concurrently reporting seriously violent behavior conclusions exposure violence media associated concurrent reports seriously violent behavior across media games music newer forms violent media seem especially concerning pediatrics
objectivesto examine month change life space mobility predictor subsequent month mortality community dwelling older adults cohort study dwelling older adults five counties university study aging random sample medicare beneficiaries stratified according sex race rural urban residence recruited november february followed telephone interview every months subsequent years data determined informant contacts confirmed using national death index social security death index life space measured interview using life space assessment validated instrument assessing community mobility eleven thousand eight hundred seventeen month life space change scores calculated years follow generalized linear mixed models used test predictors mortality subsequent month intervals hundred fifty four deaths occurred within months two sequential life space assessments controlling age sex race rural urban residence comorbidity life space score life space decline preceding month interval predicted mortality point decrease life space resulted increase odds subsequent months odds ratio space score beginning month interval change life space months associated significant differences subsequent month mortality life space assessment assist clinicians identifying older adults risk short term mortality
purpose review pain one common symptoms associated new diagnosis cancer subsequent treatment unfortunately remains around one third patients recently postulated one mechanism failure recognize pain one attractive option case pain pain associated side effects prescribed opioids use means targeted pain relief potentially fewer side effects present review summarizes evidence base various available treatment localized pain recent findings recent evidence base established treatments examined variety novel previously used therapies considered summary use localized pain associated malignancy remain valuable option many advantages systemic treatments addition reports efficacy growing body evidence consider early use topical context authors proposed guideline including use aid management pain
ability derive functional thyroid follicular cells embryonic stem cells induced pluripotent stem cells provide potential therapeutic benefit patients congenital post surgical hypothyroidism furthermore understanding process thyroid follicular cells develop also provide great insight key steps regulate development tissues derived review advances understanding process thyroid follicular cell development including creation two models allowed rescue hypothyroid mouse recipients transplantation thyroid follicular cells derived mouse rapid progress field suggests success achievable human near future additionally availability derived thyroid follicular cell models provide ideal systems explore genetic mutations drugs illness impact thyroid function cell autonomous fashion elsevier ireland ltd rights reserved
competition collaboration two universal ingredients human cultures competition observed time phenomenon helped people achieve best potentials various fields competition also helped individuals achieve achieved beyond limits also said cooperation collaboration used achieve specific goals objectives hence competition collaboration vital creating healthy learning process among students paper discusses competitive collaborative platform learning process two selected online courses electrical engineering using platform developed labview programming language community students encouraged compete online try reduce block diagrams subsystems control engineering reduce given series parallel resistor circuits shortest time amount steps possible end trial students view finish time students share online individual solutions community discuss ideas reduction techniques find via public online creates means learning community platform helps induce competitive collaborative perspective learning pathway students thereby improving interest experience students selected subject areas platform uses online server maintain communications students various locations students view timed performance counterparts leadership board thereby induced competition learning community also monitor activities community server portal
return oriented attacks extremely challenging operating systems popular mobile running arm android even vulnerable attacks due weak implementation absence effective control flow integrity enforcement paper leveraging specific arm features instruction randomization strategy mitigate attacks android even threat single leakage vulnerabilities proposed registers functions instructions registers function branch targets direct indirect branch instructions potential changed randomly without knowledge runtime instructions layout repeated control flow transfer exploits furthermore instruction randomization idea implemented android runtime art corresponding evaluations proved capable introduce enough randomness discovered functions applications shared libraries file compiled besides evaluations real world exploits also confirmed effectiveness mitigating attacks within acceptable performance overhead
mathematical modelling theoretically established tool developing solar heating systems using transfer functions know transfer functions system outlet temperature predicted function input variables solar irradiance inlet temperature environment temperatures dynamic analysis carried stable system control effectively designed based tried methods control engineering purposes new validated transfer functions solar heating systems worked study based mathematical model found literature applied successfully field transfer functions used dynamic analysis control design solar heating systems dynamic analysis presented efficiency proposed stable control demonstrated respect real solar heating system elsevier ltd rights reserved
increasing fuel costs regulation emissions encouraging operators researchers seek improvements marine vessel efficiency area vessel electrical systems increasing choices result research development past decade giving rise number promising new technologies promising new battery developed existing enhanced nano technology fuel cells now permanent magnets enabling novel motor topologies solar panel prices decreasing addition new technologies recently vessels new developments electric vehicles grid electrical systems applicable marine environment article reviews emerging electrical technologies potential improving vessel efficiency within next decade
based application guidance enterprise internal control engineering project paper takes listed companies construction industry research samples development rules internal control quality construction enterprises two aspects self evaluation verification goal achievement analyzed impact internal control quality corporate value study finds internal control quality companies concerned improving especially internal control quality engineering projects significant positive correlation companies sustainability current market value study provide support serve references future efforts strengthen establishment internal control quality upgrade corporate value
aim role uric acid risk factor cerebrovascular diseases controversial study aimed investigate relationship serum uric acid level risk cerebrovascular events middle aged non obese chinese men methods included participants health examination center hospital june june clinical examination medical records collected annual health examination hazard ratios hrs uric acid cerebrovascular events calculated cox proportional hazards models generalized additive model threshold effect analysis used explore non linear relationship serum uric acid level incidence cerebrovascular event result mean follow time months participants classified four groups serum acid quarter hrs cerebrovascular events respectively compared reference actual incidence conditional incidence cerebrovascular events high serum acid group higher low serum acid group stratified turning point mol also showed strong prognostic accuracy multiple variable based score years years area receiver operating characteristic roc curve respectively conclusion serum uric acid level strong risk factor cerebrovascular events
objectives present study examined factors associated emergence cessation youth victimization taiwan methods total students high schools assessed grade follow performed grade self administered questionnaires collected multiple logistic regression conducted examine factors results multivariate analysis results indicated higher levels risk factors online game use exposure violence media internet risk behaviors cyber school bullying experiences grade coupled increase risk factors grades used predict emergence victimization contrast lower levels risk factors grade higher levels protective factors coupled decrease risk factors predicted cessation victimization conclusion online game use exposure violence media internet risk behaviors cyber school bullying experiences used predict emergence cessation youth victimization
report patient developing postoperative peritoneal infection aspergillus serum levels negative throughout time course levels peritoneal fluids yielded high results serological testing peritoneal fluids fungal antigens useful easily applicable tool support diagnosis represents rare type invasive fungal infection
new anticancer drug unique mechanism action cell cycle transition major pathway via urine accounting radioactive dose administered human mass balance study profiling urine samples resulted detection several radioactive peaks purpose present investigation elucidate chemical structures observed metabolites collected fractions chromatographic separation urine samples fractions analysed using tandem mass spectrometry propose chemical structure metabolites urine metabolism complex consisting oxidative hydrolysis acetylation clinical relevance observed metabolites needs investigation
present case sarcoma occurring site without preceding radiotherapy chemotherapy occurring sites components rare although sarcoma like lesions sometimes reported glioma targeted radiotherapy without preceding radiotherapy quite rare moreover cases sarcoma without components occurring site never reported case fluorescent situ hybridization analysis revealed deletion first tumor second tumors additionally immunohistochemistry revealed mutated dehydrogenase tumors taken together findings suggest monoclonal tumor origin consequently case indicate new mechanism development lesions occurring site glioma
gene implicated synaptic plasticity thereby learning memory cognition methylation gene necessary memory development age dependent phenomenon aging general reported affect methylation gene however known age dependent variation methylation gene using brain tissues male female mice various age groups sex steroid hormones testosterone beta estradiol modulators restriction enzymes hpa southern blotting technique studied methylation upstream sequences gene data reveal methylation upstream sequences include cpg islands promoter region utr gradually increases due advancing age sexes beta estradiol lowers methylation significantly brain mouse male female mouse age dependent manner testosterone affect alteration methylation attributed altered dna methyl transferase activity age increases young old beta estradiol regulate activity age sex groups whereas testosterone similar effect regulation methylation cpg island utr beta estradiol lead gene especially old age finding methylation novel implications understanding fragile related disorders age dependent alteration ltd
objectives research lacking emotional effects families serious chronic illness infants examined effect diagnosis serious liver disease infants upon parent psychological symptoms family functioning hypothesized parent psychological symptoms family functioning father engagement predict infant emotional outcomes methods parents infants recently diagnosed serious liver disease completed validated questionnaires parent stress family function impact illness family father engagement measures repeated year addition child behavior checklist results parents infants participated parent stress family functioning scores elevated parent psychological symptoms family function father engagement predict infant outcome mothers infant diagnosis number outpatient visits impact illness family explained variation fathers socioeconomic status infant diagnosis whether infant transplant impact illness family explained variation conclusions parents families appear resilient coping serious infant illness infant diagnosis parental perceptions high impact illness family indicators negative emotional outcomes infants serious liver disease psychosocial interventions infants chronic illness target reducing impact illness family
study examined direct indirect pathways maternal control aspects childrens self regulation executive functioning behavioral regulation via maternal emotional support two hundred seventy eight children primary caregivers mothers participated laboratory visits children years teachers reported childrens behavior year assessment maternal control measured using adult temperament questionnaire maternal emotional support observed semistructured mother child problem solving task year assessment childrens executive functioning measured using laboratory tasks designed assess updating working memory inhibitory control cognitive flexibility whereas behavioral regulation assessed via teacher report questionnaires childrens attention control discipline persistence work habits results structural equation modeling indicated controlling child gender minority status maternal education maternal control indirectly associated child executive functioning behavioral regulation maternal emotional support maternal control direct association childrens teacher reported behavioral regulation observed executive functioning findings suggest maternal control key contributing factor development childrens self regulatory competencies impact maternal emotional support
concept mapping takes values infinite dimensional functional space studied mathematical community since third decade last century effort produced range important contributions many already made way applied sciences successfully used facilitate numerous practical applications across various fields surprisingly enough one particular field benefited contributions much greater extent still relies finite dimensional models approximations thus missing numerous advantages offered adopting general framework field image processing focus study particular paper introduce alternative approach analysis multidimensional imagery data based mathematical theory function valued mappings addition extending various tools standard functional calculus generalize notions fourier fractal transforms followed application processing imaging data applications future extensions work discussed
background health risk behaviours prominent late adolescence young adulthood yet population level research examining relationship drug alcohol use sexual health behaviour among young people scarce despite public health calls integrated approach health improvement objective understanding scale nature relationship using contemporary data third national survey sexual attitudes lifestyles methods analyses data stratified probability survey men women aged undertaken using computer assisted personal interviewing carried logistic regression used explore associations reporting frequent binge drinking weekly recent drug use within past multiple types substance use key sexual risk behaviours adverse sexual health outcomes examined sociodemographic profile health behaviours attitudes reported risky young people defined reporting type substance use plus non condom use first sex new partner last year results men women reporting frequent binge drinking recent drug use likely report unprotected first sex new partner last year first sex last partner recently meeting emergency contraception use last year sexually transmitted infection diagnosis past associations sexual risk frequently stronger reporting multiple substance use particularly among men profile risky young people differed old conclusions nationally representative study substance use strongly associated sexual risk adverse sexual health outcomes among young people qualitative event level research needed examine context motivations behind associations inform interventions address inter related behaviours
objectives hypotheses systematic review following prevalence post traumatic stress disorder ptsd differ various types chronic pain consistent evidence associated ptsd methods studies fulfilled inclusion exclusion criteria review grouped according type reported prevalence ptsd grouping determined patients studies group additionally patients combined percentage studies found association ptsd determined consistency evidence represented percentage studies finding association rated according agency health care policy research guidelines results grouping ptsd prevalence differed ranging low chronic low back pain high veterans prevalence general population studies found association ptsd generating consistency rating consistent multiple studies three generally consistent rating veterans grouping received finding inconsistent rating conclusion results systematic review confirmed hypotheses review
present investigation examined three salient features narrative thinking situation model construction linguistic perspective taking influenced social inference process results four experiments indicated compared given objectives perceivers given narrative objectives likely make situation rather trait attributions observed behaviors experiment less likely make implicit trait inferences experiment less likely rely behavior valence making evaluative judgments experiment linguistic analyses indicated narrative construction consistently creation situation models events linguistic situation model creation mediated relationship narrative inferences experiment confirmed mediating role situation models perceivers narrative objectives made trait inferences behaviors inconsistent contextual information role core narrative features social perceptions discussed
allogeneic hematopoietic stem cell transplantation remains sole curative option myelofibrosis many transplantation recipients receive reduced intensity conditioning regimen owing age comorbidities however little published evidence guide choice regimen study compared outcomes patients received frequently used regimens patients myelofibrosis total patients underwent allograft procedure group group developed complex statistical model involving weighting adjustment permit comparison groups weighting incidence acute graft versus host disease group group corresponding incidence chronic respectively year progression free survival group versus group year overall survival rate group versus group mortality group group multivariable analyses revealed significant differences groups however relapse rate significantly lower group hazard ratio whereas trend toward reduced seen group hazard ratio conclusion regimens appear efficient mediating disease control used successfully condition patients myelofibrosis regimen appears induce regimen augmented control disease leading comparable overall survival rates regimens american society blood marrow transplantation
objectives matrix regulated transcription factors facilitate carcinoma cell invasion family member expressed specifically epithelial tissues association study investigated whether regulates invasion oral squamous cell carcinoma scc via transcriptional activity mmp methods used human oral scc lines expression mmp detected situ hybridization immunohistochemistry invasion assay northern blotting used detect invasion activity activity expression mmp luciferase assays mutation analysis used transcriptional analysis mmp promoter region results expressed intermediate layer invasive area mmp expressed oral scc tissues suppressed invasion activity kda activity result transfection regulates mmp expression negative manner binding site mmp promoter contributed suppression conclusions findings indicate negatively regulates invasion oral scc via transcriptional suppression mmp
since also called green occurred every summer yellow sea causing environmental economic problems number studies used satellite observations estimate severity estimating size duration however critical parameter namely biomass never objectively determined due lack measurements study laboratory experiments conducted measure biomass wet weight per unit area corresponding spectral reflectance robust relationship established link biomass per area reflectance based floating algae index lab based model validated situ measurements estimated relative uncertainty million june minimum daily biomass million ability estimate biomass given locations near real time modis images expected significantly enhance capacity existing monitoring system provide quantitative information decision making authors published elsevier inc
gas turbines fall within category complex systems described using nonlinear stochastic differential equations constitute grounds output model based system identification shown recently one extract governing parameters namely linear growth rate nonlinear component feedback using dynamic pressure time series highly relevant practical systems actively controlled due lack cost effective actuators stability given linear growth rate results combination acoustic damping coherent feedback flame paper shown possible quantify acoustic damping system thus separate contribution linear growth rate one flame achieved simple way simultaneously acquired acoustic pressure data provides additional approach unravel observed time series key mechanisms governing system dynamics straightforward method illustrated using experimental data combustion chamber operated several linearly stable unstable operating conditions
background aims mild cognitive impairment mci present patients early stage parkinson disease however difficult detect subtle impairment without objective cognitive testing methods data obtained parkinson progression marker initiative participants administered cognitive assessment brief neuropsychological battery participants classified mci scored standard deviation normative mean domains based upon established criteria sensitivity specificity clinical detection mci determined results overall accuracy clinical detection mci although clinical determination highly specific confidence interval sensitivity poor conclusion identifying mci early stage based clinical interview alone appears insufficient inclusion objective cognitive tests allowing normative sample comparisons needed increase detection cognitive impairment population
chapter reviews smart high performance materials currently used protective investigated researchers protective applications fibres high strength heat resistance chemical resistance electrical conductivity discussed materials piezoelectric properties sensing actuation phase change materials absorb release heat shear thickening fluids briefly covered protective films membranes methods manufacture described derived natural sources applications carbon nanotubes reviewed discussion given outstanding properties individual nanotubes yet fully exploited macroscopic assemblies pure fibres composites polymer resin
several commercial financial expert systems used trading stock exchange however predictions somewhat limited since primarily rely time series analysis market rise internet new forms collective intelligence google emerged representing new generation knowledge bases information publicly companies capturing web traffic statistics reflect collective interest google become important knowledge bases research hypothesize combining disparate online data sources traditional time series technical indicators stock provide effective intelligent daily trading expert system three machine learning models decision trees neural networks support vector machines serve basis inference engine evaluate performance expert system present case study based apple stock expert system accuracy predicting next day stock movement outperforms reported rates literature results suggest knowledge base financial expert systems benefit data captured experts like google knowledge base combining data disparate sources help improve performance financial expert systems use simple machine learning models inference rule generation appropriate rich knowledge database finally intelligent decision making tool provided assist making trading decisions stock commodity index elsevier ltd rights reserved
background tobacco smoking increased among youth across globe including continues common traditional form smoking tobacco pakistan range behavioral pharmacological therapies available support people quitting cigarette smoking however little evidence exists efficacy therapies achieving abstinence among tobacco smokers objective study assess efficacy added behavioral support tobacco smoking cessation measuring validated continuous abstinence tobacco smokers methods design two arm double blind placebo controlled randomized trial conducted four districts pakistan study participants include adults using without concomitant cigarette forms tobacco smoking daily basis least months willing quit individually participants one two arms trial participants intervention arm receive behavioral support control arm receive placebo behavioral support primary outcome continuous abstinence least months week verified carbon monoxide level ppm secondary outcomes include verified day point abstinence weeks relapses different assessment points tertiary outcomes include assessment withdrawal symptoms using mood physical symptoms scale smoking dependency using dependency scale monitoring adverse outcomes discussion efficacy trial require subsequent effectiveness trial definitive evaluation intervention
nature daylight found positively influence health findings however found two separate research domains paper presents overview effects found daylight nature health health related concepts stress mood executive functioning self regulation overlap effects found occurrence phenomena paper points need consider daylight factors investigating effects nature vice versa furthermore existence possibly shared underlying mechanisms discussed need research paradigms dependent variables used two research fields last view beneficial effects phenomena health objective raise awareness amongst general public designers health practitioners use naturally available phenomena full potential
model created calculating balanced ratios flow rate sediment branches river model based extremity law energy dissipation rate involves solving simultaneous equations flow sediment motion uniform flow open channel model verified measured data obtained branches yangtze river china parameters influence ratios river width channel roughness total inflow analysed found balanced ratios sensitive river width roughness total inflow measures regulate branch compared analysed conclusions study provide theoretical basis future regulation river branch
cross section questionnaire based study carried january till december compare intellectual wellness awareness basis gender teachers basic sciences medical universities pakistan data collected public private medical universities pakistan questionnaire tailored wellness wheel responses aggregated eight questions dimension obtain aggregate score reliability questionnaire measured using cronbachs alpha average intellectual score minimum score maximum frequency keeping informed research updates significantly higher males emphasized significantly better awareness male medical teachers involved teaching medical sciences public private medical universities pakistan
increasing evidence suggests numerous transcription factors required mammalian cells phenotype among ubiquitously expressed family member role mediating tumor metastasis non small cell lung cancer explored investigation reduced expression found lung adenocarcinoma tissues compared adjacent non tumor tissues associated better overall survival low expression also found nsclc cell lines cells recombinant expressing constructs developed transfected cells cells immunofluorescence assay qrt pcr western blot analysis used measure change epithelial markers cadherin catenin mesenchymal markers cadherin vimentin wound healing assay transwell assay used measure relative cell invasion ability mtt assay assay cell cycle distribution analysis used confirm effect cell proliferation chip seq luciferase reporter gene assays used detect target genes regulated bioinformatics potential mirnas target study demonstrated played major roles nsclc emt directly targeting cadherin found regulated nsclc cell growth suppressing expression cyclin suggested multifunctional regulator nsclc expression regulated mir serve promising therapeutic target nsclc
spondyloarthritis spa usually characterized early inflammatory involvement joints constitutes one important classification criteria according spondyloarthritis international society criteria include inflammatory spine lesions detected mri although spine involvement common axial spa spine mri lesion often retrieved spa specific found many diseases malignancy osteoarthritis present case year old woman presented worsening low back pain thoracic spine mri showing bone marrow edema whole vertebral body owing peculiar presentation together pain anti inflammatory drugs nsaids slight increase biomarker malignancy suspected therefore patient underwent bone single positron emission computed tomography positron emission tomography repeated mri without reaching diagnosis finally joints mri performed joints emerged fundamental formulate diagnosis
introduction biologic therapy revolutionized treatment pathways psoriatic joint skin disease also provided useful tool pathological pathways condition covered review presents data clinical biological effects targeted therapy psoriatic arthritis psoriasis therapeutic agents covered include inhibitors tnf inhibitors axis inhibitors intracellular small molecules involved transduction inflammatory signal trial data clinical imaging efficacy reviewed parallel studies biological effects tissue level pathological insights gained use treatments commentary close relationship exists specific pathological types clinical manifestations psoriatic disease including responses treatment studying relationships likely improve understanding disease enable rational selection specific treatments patients specific
accelerator mass spectrometry extremely sensitive nuclear physics technique developed mid dating historical technique centres round use tandem van accelerator generate potential energy permit separation elemental single atom level first used early analysis biological samples containing enriched toxicology cancer research since time biomedical used study metabolism animals humans pathways drug metabolism biomarkers metabolism endogenous molecules including vitamins dna protein binding studies clinical diagnosis new drug development concept relies known human phase used obtain early human metabolism information candidate drugs arising discovery various aspects reviewed article perspective future applications provided
background obesity considered chronic disease difficult treat first cause death world predictable surgical approach limited patients severe obesity intermediate group candidates immediate surgery adjustable system currently recommended weight reduction bridge bariatric surgery methods retrospectively studied patients received january july prospectively studied patients receive july august aim study compare two systems terms weight loss complications maintenance weight removal procedure median weight loss median bmi end therapy results major complications occurred month follow weight loss month weight loss compared previous measurement month follow weight loss compared previous measurement conclusions effective treating overweight patients bmi rate complication reported according literature significant differences two procedures terms outcomes
background improved diagnostics needed controlled human infection model accelerate development translation evaluated blood culture pcr assay detecting infection controlled human infection compared test performance optimally performed blood cultures methodology principal findings culture pcr amplification blood samples performed alongside daily blood culture participants undergoing challenge study endpoints diagnosis fever overall participants reached positive blood culture cultures positive culture pcr assay result five non participants produced culture pcr indicating infection overall sensitivity specificity assay compared study endpoints found significant difference blood culture culture pcr methods ability identify cases pairs binomial test clinical stool culture metadata demonstrated additional culture pcr amplification positive individuals likely represented true cases missed blood culture suggesting overall attack rate rather several participants positive culture pcr results soon challenge providing new evidence occurrence early primary conclusions significance overall culture pcr assay performed identifying extra cases compared routine blood culture alone despite limitations widespread field use benefits increased diagnostic yield reduced blood volume faster turn around time suggest assay enhance laboratory diagnostics research applications high incidence settings author published elsevier ltd behalf british infection association
interleukin cytokine covalently bound proteins recently closely associated development several chronic autoimmune diseases psoriasis psoriatic arthritis inflammatory bowel disease released activated dendritic cells interacts receptor cells thus promoting intracellular signaling pivotal step driven pro inflammatory axis aimed block binding cytokine cell surface receptor novel inhibitory protein targeted subunit human goal used combinatorial library derived scaffold albumin binding domain protein display selection yield collection derived targeted variants called clones analyzed elisa western blot dna sequencing provided different sequence variants characterized using silico docking combination cell surface competition binding assay identified group inhibitory candidates substantially diminished binding recombinant human cells best blockers inhibited driven expansion producing primary human cells thus novel represent unique targeted probes useful epitope mapping studies used designing novel targeted anti inflammatory biologics
paper presents digital hardware implementation real time simulator multiphase drive using field programmable gate array fpga device simulator developed modular hierarchical design using high speed integrated circuit hardware description language hence simulator flexible portable state space representation model suitable fpga implementations proposed dual three phase induction machine simulator also models two level pulse gate bipolar transistor based voltage source converter pulse width modulation scheme measurement system real time simulation outputs stator currents rotor speed validated steady state transient conditions using reference experimental test bench based rated power accuracy proposed digital hardware implementation evaluated according simulation experimental results finally statistical performance parameters provided analyze efficiency proposed hardware implementation method
background elevated risk one aim skin care specific professional individual prevention programme germany ensure appropriate use safety measures patient treatment initially often think use patients acceptance protective measure objective study assess practicality use physiotherapy qualitative investigation customer acceptance quantitative investigation methods structured problem focused interviews usage held skin diseased skin care data evaluated using qualitative content analysis clients acceptance tested controlled randomized three setting study subjects received back evaluated quality aspects questionnaire wearing either made rubber non test used test group differences result majority participating considered use protective practical useful measure however problems everyday practice special therapy methods reported analysis questionnaires response rate quality aspects willingness pay regarding client without showed non result conclusion convincing individual benefits wearing crucial implementation preventive measure patients services therapists wear treatments consequently usage unlikely result loss practice custom
paper presents issues concerning realization paradigm sustainable design design offices special attention given relevant technical formal functional solutions domain interior architects creating built environments adequate indoor quality substantial reduction negative impact natural environment presented sustainable architectural completed last decade gained established independent scientific institutions accordance rating systems paper analyzes formal methods proper space planning assure high indoor environment quality parameters end users office terms optimum recreational areas workers visual contact natural valuable surroundings requirements satisfactorily met properly shaped inner space elements including space dividing structures rational effective use building materials technical technological devices incorporated inner space mentioned paper supposed essential complement design methods proper daylight transmission distribution discussed examples indicate necessity collaboration interior architects professionals green building whose design contributions accepted integrated interior design process sustainable architectural design
study first examine relationship emotional tears emotional although phenomena related peak states moved details temporal occurrence associated levels physiological arousal remained unknown study used emotionally powerful film scenes self selected participants findings show even within peak moments emotional arousal intensity possible overlap tears maximal within peak moments side stimulus found displays prosocial behavior play crucial role tears finally based results formal film analysis tears eliciting clips provided participants compared randomly extracted equally long control clips films show technical making clips optimized display social interaction emotional expressions
enhanced inflammation associated alzheimers disease diseases lewy body pathology parkinsons disease dementia lewy bodies one issue whether amyloid pathology features alpha synuclein pathology similar different effects brain inflammation aim study examine certain features inflammation changed brains increasing pathology assess measured levels anti inflammatory protein pro inflammatory protein intercellular adhesion molecule cingulate temporal cortex total cases classified according unified staging system disorders changes levels correlate pathology pathology negatively correlated density phosphorylated tau amyloid plaque density positively correlated pathology measures double immunohistochemistry phosphorylated alpha synuclein markers microglia showed limited association microglia pathology microglia strongly associated amyloid plaques phosphorylated tau results suggest different features inflammatory pathology diseases associated abnormal alpha synuclein compared elsevier inc rights reserved
nanostructures exhibiting improved physicochemical properties recently investigated many useful applications context length diameter prepared onto enhanced photo degradation visible light irradiation phase composition almost similar commercially available tem analysis reveals uniform dispersion spherical nanoparticles deposits entire surface specific surface area notably higher reduced slightly loading exhibited increased relaxation time pairs compared due structure loading improves charge separation efficiency complete bare loaded light irradiation formation various intermediate products monitored hplc analysis revealed loaded always exhibited times higher photocatalytic activity mostly used phase larger specific surface area higher lifetime excited charge species loading enhanced visible light absorption capacity due surface interaction elsevier ltd rights reserved
background house dust mite species releases allergens cause allergies asthma worldwide study sought clone express full length cdna encoding group allergen der methods published sequence der used design primers pcr race obtain full length cdna encoding der removal signal peptide sequence der sub cloned plasmid pet plasmid transformed escherichia coli cells expression recombinant protein purified nickel affinity chromatography identified sds page western blotting dot blotting maldi tof tested elisa ige reactivity sera children asthma bioinformatics analyses used identify features der results pcr race race full length sequence der generated confirmed nucleotide sequencing mature der expressed successfully coli identified sds page recombinant allergen purified chromatography confirmed sds page western blotting dot blotting maldi tof sera mite allergic patients reacted purified recombinant der conclusions successful production recombinant der protein revealed importance der mite allergy provides foundation study allergen diagnosis treatment symptoms wiley periodicals inc
present paper new approach sign language recognition using hand gesture analysis analysis consists extracting histogram oriented gradient features hand image using generate svm models used recognize real time hand gesture using microsoft camera approach involves three steps hand detection localization using microsoft camera hand segmentation iii feature extraction using recognition one input image first obtained using depth sensor apply method based hand anatomy segment hand eliminate errors pixels approach invariant scale rotation translation hand experimental results show effectiveness new approach experiment revealed proposed system able recognize accuracy
deployment smart grids renewable energy dispatch centers motivates development forecasting techniques take advantage near real time measurements collected geographically distributed sensors paper describes forecasting methodology explores set different sparse structures vector var model using least absolute shrinkage selection operator framework alternating direction method applied fit different var variants create scalable forecasting method supported parallel computing fast convergence used system operators renewable power plant operators test case wind power plants used show improvement forecasting skill exploring distributed sparse structures proposed solution outperformed conventional autoregressive vector autoregressive models sparse var model state art copyright john wiley sons ltd
study ray crystal structure complex escherichia coli reductase substrate used guide design mutant altered specificity previous studies shown higher affinity species different species computational alanine scanning mutagenesis visual inspection interface suggested four residues account majority interface stability individual replacement equivalent residues alanine resulted drastic changes binding affinity confirming four residues account interface stability changed match equivalent residues substrate specificity altered results suggest small subset interface residues responsible majority binding affinity species specific recognition
background smokers increasingly seek alternative interventions assist cessation reduction efforts mindfulness facilitates observation paying attention present moment openness acceptance recently studied smoking cessation intervention aims review randomized controlled trials rcts mindfulness interventions smoking cessation methods five electronic databases searched inception october identify english language rcts evaluating efficacy safety interventions smoking cessation reduction decrease nicotine two independent reviewers screened literature using predetermined eligibility criteria abstracted study level information assessed quality included studies meta analyses used method random effects models quality evidence assessed using grade approach findings ten rcts interventions tobacco use met inclusion criteria intervention duration intensity comparison conditions varied considerably studies used diverse american lung associations freedom smoking program counseling interactive learning treatment usual tau one rct rated good quality reported power calculations indicating sufficient statistical power publication bias detected overall mindfulness significant effects abstinence cigarettes per day relative comparator groups small number studies heterogeneity interventions outcomes detecting systematic differences adjunctive monotherapy interventions serious adverse events reported conclusions differ significantly comparator interventions effects tobacco use low quality evidence variability study design among small number existing studies publication bias suggest additional high quality adequately powered rcts conducted elsevier ltd rights reserved
purpose study determine environmental impacts associated deep energy efficiency using life cycle assessment prototypical model office building located new zealand used case study included major changes building envelope additional insulation modified wall window ratio solar technical replacement lighting system study included identification environmental hot spots deep energy consideration effect different electricity new zealand total environmental impact building compared existing building different operation periods environmental payback period calculated impact category results study indicate deep energy associated significant environmental impacts mainly due use energy intensive construction materials however yields net reductions impact categories building longer operational period environmental impacts buildings operation mainly associated new electricity generated coal future scenarios new electricity mix reduced share electricity generated coal environmental benefits avoided electricity consumption also reduced study concludes measures promote energy efficiency office buildings significant proportion operational energy provided renewable energy sources carefully considered reduce overall environmental impacts elsevier ltd rights reserved
optimal static output feedback control used obtain control force desired magnetorheological damper fitted ground first three building model modified model considered obtaining damper response exhibits non linear relationship damper force input voltage states hence obtaining input voltage realize desired control force non trivial task two voltage control laws proposed inverse quadratic voltage law inverse voltage law based constraint filter implemented addition existing voltage law results controlled response building obtained terms peak rms values response quantities drift displacement acceleration compared existing results obtained via linear quadratic gaussian control using via passive control constant saturation voltage applied reduction maximum peak drift maximum rms drift performance index obtained using control compared passive control quantities rms displacements attenuated comparing control control exception maximum peak drift attenuation occurs peak rms values accelerations reduced via compared passive control except considering first accelerations using passive control peak value applied damper force least using control copyright john wiley sons ltd
world congress psychiatric genetics sponsored international society psychiatric genetics took place october november total participants gathered discuss latest findings field following report written early career travel student assigned one sessions manuscript represents topics covered presentations conference contains major notable new findings reported copyright wolters kluwer health inc rights reserved
effect modern continuous methods drug disposition pharmacokinetics response poorly studied pharmaceutical manufacturers little incentive perform pharmacokinetic studies patients undergoing studies neither recommended existing food drug administration fda guidance documents required new drug approval action urgently needed address knowledge deficit kidney health initiative assembled work group composed clinicians scientists representing academia fda pharmaceutical dialysis industries expertise related pharmacokinetics work group critically evaluated key considerations assessment pharmacokinetics drug dosing practical constraints related conducting pharmacokinetic studies critically patients generalizability observations made context specific prescriptions specific patient populations order identify efficient study designs capable addressing knowledge deficit without drug development considerations standardized assessment pharmacokinetics development corresponding drug dosing recommendations critically patients receiving proposed
paper development array weather radar consists dual polarized antenna circular planar phase array elements discussed radar capable measuring rainfall distribution less several tens seconds digital beam forming important component development process array radar paper precipitation radar signal simulations performed taking consideration radar concepts order discuss estimation accuracy precipitation profiles differential specific differential phase correlation coefficient two methods based fourier minimum mean square error mmse methods comparison performance two methods indicates mmse superior accuracy effect stable robust main lobe adaptively suppressed side lobes mmse also provides precipitation measurements eliminating directional dependence beam pattern improving accuracy measurements also shown estimated accuracies precipitation profiles almost independent number pulses
introduction pharmacists play key role counter emergency contraception client aims study aims evaluate knowledge counter services provided pharmacists methods questionnaire based survey conducted capital city india results approached agreed participate study number month per pharmacy varied month sixty two percent pharmacists claimed majority clients repeated use month clients referred doctors directly approached pharmacists nearly one third clients adolescents sixty seven percent pharmacists adequate knowledge asked last menstrual period time since last unprotected intercourse pharmacist whether one multiple unprotected acts intercourse regular contraceptive method used explored reason intake explained dosage schedule clients half explained client experience side effects none pharmacists advised clients sexually transmitted disease screening clients regarding regular contraception conclusion improving quality services provided pharmacists clear misconceptions clients promote subsequent regular contraception along avoid sexually transmitted diseases
autoimmune rare disorder immune dysregulation caused mutations autoimmune regulator gene individuals affected develop clinical syndrome characterized abnormalities production organ specific autoimmune manifestations inflammatory arthritis usually described part syndrome sporadic cases reported describe case preschool age girl presented hepatitis interstitial chronic years age found two compound heterozygous disease associated mutations gene also conducted literature review main characteristics inflammatory arthritis patients case review demonstrate inflammatory arthritis although rare early manifestation diagnosis considered multiple organ specific autoimmune manifestations especially adrenal failure accompany joint symptoms genotyping interpretation take account mutations found exons gene compound common cases one mutated alleles found
many object instance retrieval systems typically based matching local features however local descriptors serve low level clues sufficiently distinctive prevent false matches recently deep convolutional neural networks cnn shown promise semantic aware representation many computer vision tasks paper propose novel approach employ cnn evidences improve matching accuracy plays critical role improving object retrieval performance interference noise extract compact cnn representations number generic object regions query adaptive method proposed choose appropriate cnn evidence verify pre matched pair two different visual matching verification functions introduced evaluated moreover investigate suitability fine tuning cnn proposed approach extensive experiments benchmark datasets demonstrate effectiveness method particular object retrieval results compare favorably state art methods acceptable memory usage query time elsevier rights reserved
integrated hydrological groundwater modeling studies carried identification suitable sites rainwater harvesting structures groundwater augmentation campus based studies ten check dams two contour one recommended existing stream channels valley respectively likely water structures calculated keeping view length width stream channels based study groundwater flow model using carried keeping view hydrologic conditions area net rain water structures groundwater regime calculated seasons varied net enhancement groundwater recharge structures around year water level existing rise present level future groundwater augmentation
despite implementation multiple sophisticated safety barriers undesired disaster petroleum industry still happens incidents show crude price operators toward cost cutting plans plans short terms significantly reduce exploration operation costs relieve financial pressures hand measures also compromise balance among safety reliability cost long term potentially lead catastrophic accidents current regulation mexico region requires operators report single value worst case discharge possible however provide additional value manage risk uncontrolled flow event impact marine environment paper practical comprehensive oil risk assessment method introduced couples reservoir models distribution uncertainties risk picture uncontrolled flow events statistical design experiments conducted determine important uncertainties risk shown sensitivity analysis method guide operators allocate limited resources important barriers make proper risk reduction plans risks effectively controlled institution chemical engineers published elsevier rights reserved
paper discuss asymptotic behavior doubly nonlinear problem describing vibrations string beam system models suspension bridge model obtain existence uniqueness solutions exponential stability homogeneous system provided constant axial force smaller critical value general existence regular global proved external loads independent time
background disease established atopic dermatitis generally associated low diversity skin microbiota staphylococcus aureus dominance temporal transition skin microbiome early infancy dysbiosis established unknown methods randomly selected children scope evaluating longitudinal impact using neurological endpoints baseline longitudinal birth cohort microbiome sampling points first months life skin sites relevant nasal tip identified infants compared randomly selected control infants performed bacterial ribosomal rna sequencing analysis directly clinical samples results bacterial community structures diversity shifted time suggesting age strongly affects skin microbiome infants unlike established patients communities disease aureus comparing patients control subjects infants affected skin month statistically significant differences bacterial communities month compared infants unaffected month particular significantly less abundant infants affected month suggesting genus protect later development conclusions study suggests month old infants aureus additional studies needed confirm whether colonization modulates skin immunity attenuates development
green roofs becoming trend urban areas thermal performance buildings promoting removal atmospheric pollutants acting possible water collection spots rainwater harvesting systems buildings also contribute management stormwater runoff reducing flood peaks technologies enhanced mediterranean countries water scarcity increasing occurrence extreme events becoming significant result climate change extensive pilot three aromatic plant species thymus thymus designed study several parameters affecting rainwater runoff operation months physico chemical analyses roof water runoff turbidity conductivity chemical oxygen demand shown water sufficient quality non potable uses buildings toilet flushing innovative approach allowed development expression predict monthly runoff coefficient system parameter essential planning designing combined rainwater harvesting systems mediterranean climate study contribution improving basis design rainwater harvesting systems buildings extensive mediterranean climate
previous work suggests estradiol regulates expression hippocampal hippocampus dependent spatial memory mice generate neuronal oscillatory activity gamma frequency range gamma oscillations closely linked higher cognitive functions selective estrogen receptor modulator shows beneficial effects human cognitive performance peripheral side effects unlike estradiol biological mechanisms benefits clear study aimed investigate whether estradiol modulate hippocampal gamma band oscillations spatial memory performance female mice ovariectomized implanted subcutaneous either estradiol placebo adulthood local field potentials recorded dorsal hippocampus mice performing maze hippocampus dependent spatial memory task caused deficits spatial memory accompanied significant reduction hippocampal gamma oscillations specifically decision making estradiol rescued behavioural electrophysiological deficits data significant implications disorders cognitive impairment altered gamma oscillations apparent schizophrenia elsevier ltd rights reserved
exploring resting state brain functional connectivity autism spectrum disorders asd using functional magnetic resonance imaging fmri data become popular topic past years data standard brain template consist voxel specific points time human subject ultra high dimensionality makes voxel level functional connectivity analysis involving four billion voxel pairs statistically computationally inefficient work introduce new framework identify functional brain network anatomical region level individual propose two pairwise tests detect region dependence one multiple testing procedure identify global structures network limiting null distribution test statistic derived also shown tests rate optimal alternative block networks sparse numerical studies show proposed tests valid powerful apply method resting state fmri study autism identify patient unique control unique hub regions findings biologically meaningful consistent existing literature elsevier inc rights reserved
concept sustainability regarded environmental economic social usually identified triple bottom line sustainability often represented three therefore construction sustainable environmentally economically socially sustainable however extent green building rating tools evaluate three sustainability research aims analyze effectiveness eight international green building rating tools evaluating environmental economic social sustainability buildings credit points rating tool initially categorized based related category sustainability comparison analysis carried based normalized score finally comparison result presented radar diagram three case study buildings also analyzed based credit points achieved accordingly environmental sustainability widely considered green building rating tools economic sustainability rarely evaluated social sustainability evaluated green building rating tools approximately amount credit points allocated rating tool american society civil engineers
previous research demonstrated way adults interact children autism great impact spontaneous communication however date studies focused modifying adults behaviour even fewer conducted school settings actively involve teaching staff designing intervention aims study twofold explore extent staff able build good practice alter interactive style assess effects change childrens communication study used action research methodology involved three members staff six children autism staff researcher developed adult interactive style intervention partnership based two theoretical models child development disability data collected pre post intervention follow months end main study measure change results showed staff considerably increased number times used principles post intervention change significant impact childrens spontaneous communication three staff took active participatory role study considered positive empowering experience
overcome limitations traditional long span suspension bridges steel cables mechanical behavior suspension bridges various fiber reinforced polymer hybrid cables investigated comprehensively authors adopted prototype proposed bridge main span use suspension bridge model analysis static dynamic behaviors entire suspension bridge steel different cables analyzed using finite element method results indicate application cables long span suspension bridge benefits spanning ability improves load carrying efficiency reduces axial force cable modal analysis results show long span suspension bridge cables different materials similar mode shapes although natural frequencies bridges cables larger bridge steel cable lower self weight also revealed adoption cables decreases seismic responses suspension bridge better energy dissipation behavior cables improve flutter critical wind speed contribute overall aerodynamic stability large span suspension bridges
background systemic inflammation emerged promising marker potential mechanism underlying post traumatic stress disorder ptsd relationship posttraumatic stress pathology systemic inflammation however consistently replicated potentially comorbid illness injury common complications trauma exposure methods analyzed large naturalistic cohort sharing discrete physical mental health trauma destruction world trade center towers september evaluated relationship multiple physical mental health related indices collected routine evaluations environmental health center treatment program community members exposed disaster reactive protein crp marker systemic inflammation examined relation scores ptsd ptsd symptom clusters experiencing avoidance negative cognitions mood arousal depression anxiety controlling exposures lower respiratory symptoms age sex bmi smoking potential risks confounders results crp positively associated ptsd severity toward association depression anxiety crp positively associated experiencing avoidance symptom clusters toward associations negative cognitions mood arousal conclusions large study relationship crp posttraumatic stress pathology demonstrated association systemic inflammation stress pathology ptsd depression remained adjusting potentially confounding variables results contribute research findings suggesting salient relationship inflammation post traumatic stress pathology authors published elsevier ltd
paper proposed technique optimize power generated small scale wind turbine wind speed measurement uncertain knowledge power coefficient curve characteristic first kalman like observer used estimating power coefficient characteristic used nonlinear control strategy electrical generator power maximization uncertain power coefficient function adjusted recursive least square algorithm uses estimate power coefficient reliable information finally adjusted power coefficient polynomial computed optimal electrical generator speed reference leads system operate near theoretical optimal power methodology illustrated simulated example compared case wind speed measured
context private family professional life assumes part migration analyses however knowledge existing dynamics among immigrant families still scarce portuguese academic literature specially immigrant women organize family lives action modalities terms sense main objective research characterize analyze immigrant women experiences private family professional life research based qualitative approach inserted critical paradigm offered social empirical basis built ten brazilian immigrant women living district using thematic analysis methodology results show regular asymmetric pattern domestic child care places immigrant women receiving country bigger overload situation country origin absence family financial social support child care influence professional life often interrupted attempt respond towards women normative position asymmetric practices subject consequently strengthening inequality scheme thus conclude political economical power receiving country traditional gender roles see unequal achievement women relative men professional family spaces
augmented reality allows add virtual object real scene increasing interest last years since mobile device becomes cheap augmented reality used different domains like maintenance training education entertainment medicine show focused maintenance operations step step process presented operator order maintain element system based demonstration explain modelling propose allowing describing entire maintenance process augmented reality indeed still difficult creating augmented reality application without computer programming skills proposed model allow create tool plug existing one order create augmented reality process without deep computer programming skills
usually commercial control solutions control still use pid controllers standard although several applications advanced control refrigeration processes literature consensus optimal control solution system implementation advanced control algorithms ultimately depends accurate process knowledge form dynamic mathematical models study aims take first step toward designing adaptive stochastic mpc controller control refrigeration cycle electronic expansion valve developing stochastic dynamic models process time varying time invariant versions models identified statistical validation results show time invariant models creating basis comparison recursive estimation time varying parameters realized kalman filter factor algorithms results validation tests simulation show good results average output errors degrees indicating time varying parameters good presentation system elsevier ltd rights reserved
background studies shown recent human immunodeficiency virus hiv burden among men sex men msm china especially urban areas intervention planning resource allocation spatial analyses hiv aids case clusters required identify epidemic foci trends among msm china methods information regarding msm recorded hiv aids cases extracted national case reporting system demographic trends determined trend tests distribution case clusters examined using spatial spatial temporal scan used detect disease clustering spatial correlations cases factors determined spatial regression results china hiv aids cases identified among msm newly identified hiv aids cases among self reported msm increased cases cases among hiv aids cases recorded years old aged years based clusters hiv aids cases identified spatial analysis epidemic concentrated among msm large cities spatial temporal clusters contained main cities beijing shanghai spatial regression analysis showed sociodemographic indicators population density per capita gross domestic product number county level medical institutions statistically significant positive correlations hiv aids among msm conclusions spatial analyses revealed increasingly concentrated hiv epidemic among young msm chinese cities calling targeted health education intensive interventions early age
study objective prevalence department wellness programs unknown database wellness programs needed resource departments attempting respond council graduate medical education project purpose study survey academic wellness issues characterize initiatives establish wellness contacts wellness initiative database design internet based survey instrument distributed academic department united states setting line patients none interventions none measurements analysis continuous variables used standard means modes individual responses confidence intervals proportions calculated method main results seventy five responses potential programs obtained forty one responders expressed interest participating provided contact information recently referred staff counseling wellness resources yet many respectively never surveyed departments interest wellness resources thirty four percent wellness resources repository wellness topics strong interest respondents addiction counseling sleep hygiene peer support program stress management conflict management burnout counseling time management dealing adverse events training statistically significant difference interest willing participate across topics significant difference based need recent staff referral conclusions majority needed recently refer department member wellness resources counseling interested participating whereas minority staff interest wellness topics wellness resource repository highest interest topics related function willing participate database statistically significant differences interest across wellness topics elsevier inc rights reserved
pathological gambling alongside addictive antisocial disorders forms part broad psychopathological spectrum externalizing disorders share underlying genetic vulnerability shared externalizing propensity highly heritable continuously varying trait personality traits impulsivity novelty seeking function indicators broad shared externalizing tendency reflect neurobiological level variation reactivity dopaminergic brain reward systems centered ventral striatum examined whether individual differences ventral striatal dopamine synthesis capacity associated individual variation personality traits twelve healthy male volunteers underwent positron emission tomography pet scanning measure striatal synthesis capacity completed measure personality found levels ventral dorsal striatal synthesis capacity significantly correlated inter individual variation personality traits particularly propensity financial results consistent preclinical models behavioral addiction provide novel insights neurobiology personality based vulnerability pathological gambling externalizing disorders
following thyroid surgery levothyroxine therapy used replace deficient thyroid hormones prevent postoperative thyroid compared effects replacement therapy either liquid tablet formulation levothyroxine mood states self perceived mental thyroid hormone profile recently patients profile mood states general questionnaire items thyroid hormone profile assessed recently days patients baseline months randomization replacement therapy either liquid tablet formulation levothyroxine months levothyroxine replacement treatment significant improvements positive affect scale negative affect scale profile mood states general questionnaire items observed study population however greater variations observed patients assigned liquid levothyroxine formulation comparison assigned levothyroxine form tablet time treatment interaction positive affect scale profile mood states negative affect scale profile mood states general questionnaire items expected circulating tsh levels significantly decreased levels significantly increased levothyroxine replacement therapy changes significantly greater patients treated liquid levothyroxine formulation time treatment interaction tsh data indicate greater efficacy liquid formulation levothyroxine ameliorating mood states self perception mental thyroid hormone profile months replacement therapy recently patients
existing literature problem usually focuses business customer impact batch demands behavior business business environment paper contributes inventory problem facing batch demands using control inventory non average cost function encompasses like pattern based structural properties disclose optimality conditions ordering quantities using conditions efficient algorithms built search optimal policy discussion algorithm design separated two parts integer requirement ordering quantity practice convenient control inventory ordering quantity exactly integer multiple customers demanding size integer requirement exists closed form solution provided answer optimal ordering quantity elsevier inc rights reserved
cells respond differently antigens varying affinity presented different doses previous attempts map peptide mhc affinity onto cell responses produced inconsistent patterns responses preventing formulations canonical models cell signaling systematic analysis cell responses million fold variations affinity dose produced bell shaped dose response curves different optimal affinities different doses using sequential model rejection identification algorithms identified unique minimal model cellular signaling incorporating kinetic limited signaling coupled feed forward loop observations show model correctly predicts cell response antigen work offers general approach studying cellular signaling require full details biochemical pathways
water quality reservoir beijing year year embodied increasing concentrations cod stable high levels total nitrogen order identify causes formulate strategy pollution prevention control examined temporal spatial variations water pollution carried source identification studies routine monthly monitoring data seven water quality six hydro meteorological variables reservoir analyzed statistical techniques including correlation analysis principle component analysis addition water samples six different sites reservoir collected analyzed investigate spatial variation water quality identify water pollution sources vis spectroscopy three dimensional excitation emission matrix spectroscopy nitrogen stable isotope analysis results revealed dissolved organic matter nitrogen main pollutants principally derived anthropogenic point source pollution upper areas included domestic sewage livestock farming biodegradable organic pollutants sewage degraded form soluble microbial products aerobic microorganisms nitrogen pollutants mostly transformed nitrate nitrate refractory pollutants carried upper stream flowing reservoir accumulated effective control point source pollution upper river ecological restoration done improve water quality protect reservoir
mutations genes encoding proteins smooth muscle cell smc contractile apparatus contribute familial aortic investigate pathogenicity mutations smc required demonstrate novel method generate smc like cells human dermal fibroblasts study effect variants genes encoding proteins smc contractile apparatus patients aortic dermal fibroblasts seven healthy donors cells seven patients variants smc like cells within week duration using scaffold containing collagen induced smc comparable primary human aortic smc mrna expression smc markers confirmed protein level immunofluorescence quantification analysis western blotting patients variants effect variants splicing demonstrated mrna level induced smc allowing classification pathogenic variants conclusion direct conversion human dermal fibroblasts smc like cells highly efficient method investigate pathogenicity variants proteins smc contractile apparatus wiley periodicals inc
background short syndrome rare genetic congenital defects condition frequency disease still remains unknown case presentation report two year four month old female short syndrome present growth retardation features triangular shaped face prominent ocular depression lumbar region around consistent phenotype described syndrome molecular analysis showed presence heterozygous variant exon conclusions frequency disease still remains unknown solely several cases described worldwide
meet current diesel engine pollutant legislation important manage treatment devices paper describes development neural network based virtual sensors used estimate nox emissions exhaust automotive diesel engines suitable identification methodologies experimental tests developed aim meeting conflicting needs feasible board implementation satisfactory prediction accuracy addition since prediction control oriented models typically affected engine aging production spread components drift least square technique features exploited order overcome issues adapting virtual sensor output nox adaptive virtual sensor tested via comparison experimental data measured engine test bench common rail automotive diesel engine furthermore besides model validation experimental measurements modified simulate sensor drift order enable full assessment proposed based algorithm adaptation capabilities
first study ascertain value multidisciplinary team meetings within early pregnancy assessment unit national telephone survey identified united kingdom overall regular meetings secondary tertiary hospitals just likely hold regular meetings participants interview study expressed principal benefits regular meetings communication education effective stress management perceived additional benefits included improved care quality better patient experience enhanced team cohesion meetings least one representative every present meeting comprised ectopic pregnancies pregnancies unknown location propose number research studies build study efforts help enhance effectiveness based service
part curriculum changes south africa introductory programming language scratch first taught switching established teaching delphi nature programming scratch considerably different delphi assumed teaching scratch introductory programming language support learners understanding delphi teachers receive much training scratch study explores teachers experiences first year teaching scratch purpose research understand scratch used effectively language delphi guidelines teaching scratch introduction object oriented programming delphi qualitative research method within paradigm selected research interviews done eight randomly selected information technology teachers province north west south africa gain insight experiences teaching scratch first year implementing new curriculum findings show teachers uncertain teach programming concepts integrate problem solving algorithm design teaching scratch focus teaching scratch instead teaching programming concepts scratch emerging guidelines integration problem solving algorithm design creation opportunities expose learners error handling program testing programming concepts furthermore recommend active teaching learning strategies pair programming
date american joint committee cancer union international cancer control tumor nodes metastasis classification represents standard system evaluation prognosis solid tumors however clinical outcome significantly different patients stage therefore many efforts made aiming define new prognostic parameters indeed analyses conducted large cohorts colorectal cancer patients emphasized prognostic value tumor infiltrating lymphocytes leading development prognostic score referred commentary study colleagues recently published cancer immunology research addressing role cells prognostic markers hepatocellular carcinoma authors demonstrate represents valuable prognostic marker patients hepatocellular carcinoma undergone primary tumor resection supporting application tumor setting colorectal cancer
bioactive phosphate best known activity cell active regulating cells lymph node consequently availability cells migration peripheral tissues physiological role exploited drug first line therapy multiple sclerosis cells lymph nodes recent year elucidated exerts regulatory functions far beyond cell lymph node thus additionally regulates among others several immune cell populations peripheral tissues inflammatory conditions addition evidence mostly derived mouse models accumulated involved pathogenesis several inflammatory skin disorder receptor modulators applied effective treating skin diseases recent developments highlight pharmacological modulation receptor system potential new therapeutic strategy plethora inflammatory skin diseases impact receptor modulation inflammatory skin diseases next requires testing human patients
batch adsorption experiments carried removal methylene blue cationic dye aqueous solution using organic inorganic hydrogel nanocomposite incorporated sodium acid poly hydrogel prepared graft acid onto sodium presence agent free radical nanoparticles hydrogel exhibited high swelling capacity factors influencing adsorption capacity dye solutions initial concentration dye amount temperature investigated used propose possible mechanism adsorption adsorption process pseudo second order kinetics langmuir isotherm equation high adsorption capacity max correlation coefficient calculated isotherm equations show high efficiency thus expected good candidate water treatment elsevier ltd rights reserved
aimed study role attachment style headache severity psychological symptoms children adolescents moreover investigated association attachment style migraine severity psychological symptoms theory suggests early interpersonal relationships important determinants psychopathology pain management particular individuals insecure attachment styles shown experience pain people secure attachment style studies focused headache data attachment style pediatric headache scarce methodswe studied mean age years female male patients divided two groups according headache attack frequency high frequency patients weekly daily episodes low frequency patients episodes per month according headache attack intensity patients classified two groups mild pain allowing patient continue daily activities severe pain leading interruption patient activities forcing child bed psychological screening assessed anxiety depression questionnaires attachment style measured semi test separation anxiety test patients divided secure avoidant ambivalent attachment patterns found significant relationship attachment style migraine features ambivalent attachment common style among patients reporting high attack frequency severe pain intensity anxiety depression higher patients ambivalent attachment style moreover results showed association high attack frequency high anxiety levels children ambivalent attachment style attachment style common vulnerability factor impacts pain severity anxiety depression symptoms young particular present study provides first evidence role insecure attachment relationship pain severity psychological symptoms migraine children
year old man underwent abdominal computed tomography periodic follow following distal gastric cancer mucosal associated lymphoid tissue lymphoma conducted months earlier contrast enhanced demonstrated mass lesion heterogeneous density measuring diameter located second segment process pancreas revealed remarkable findings stomach however scope reach due altered anatomy reconstruction distal patient underwent surgical resection mass lesion clinical diagnosis lymphoma relapse orange calculus apparent extended wall stretching closed primary resection extracted calculus solid quite hard measured cut surface revealed layered structure outer areas contents center although relatively common developing within rare best knowledge first case due altered anatomy reported english literature
assessing quality aperture synthesis maps relevant benchmarking image reconstruction algorithms scientific exploitation data optical long baseline design upgrade new existing imaging facilities although metrics proposed contexts systematic study conducted selection robust metric quality assessment article addresses question best metric assess quality reconstructed image starts considering several metrics selecting based general properties variety image reconstruction cases considered observational scenarios phase closure phase large combination two three four six end end image reconstruction accomplished software several merit functions put test found effective point spread function required proper image quality assessment effective angular resolution images superior naive expectation based maximum frequency sampled array due prior information used aperture synthesis algorithm nature objects considered norm robust considered metrics linear less sensitive image smoothing high regularization levels cases considered metric allows implementation automatic quality assessment reconstructed images performance similar human selection
background context limited research investigating educational attainment risk factor low back pain influence gender commonly neglected furthermore genetics early shared environment explain substantial proportion cases need controlled investigating risk factors purpose investigate whether educational attainment affects prevalence risk differently men women controlling influence genetics early shared environment study design cross sectional prospective twin case control study patient sample adult twins twin registry available data educational attainment formed base sample study prevalence analysis considered twins available data longitudinal analysis considered twins free baseline available data follow outcome measures data lifetime prevalence activity limiting outcome educational attainment risk factor self reported methods prevalence analysis investigated cross sectional association educational attainment whereas longitudinal analysis investigated whether educational attainment increased risk developing analyses performed following sequence first total sample analysis performed twins considering individuals adjusting confounding variables selected data second control influence genetics early shared environment within pair case control analysis stratified performed complete twin pairs discordant one twin whereas twin analyses stratified gender possible interaction term determining whether gender significant moderator association educational attainment results women either general secondary university education less likely experience prevalence analysis develop longitudinal analysis educational attainment affect risk men controlling effects genetics early shared environment relationship educational status women longer statistically significant conclusions educational attainment affects differently men women higher levels education decreasing risk developing women adjusting genetics early shared environment relationship educational attainment women suggests genetics early shared environment confounding relationship educational attainment women elsevier inc rights reserved
wireless sensor networks wsns large number nodes deployed open environment gather useful required information nodes small size operating limited processing capabilities scarce working memory battery life powerful radio communicate wireless media radio waves insecure nature therefore using waves communication always opportunities different attacks network wireless techniques founded cluster based sensor network cluster heads data secure manner important collect data cluster members send sink node base station securing data propose mechanism termed inter cluster multiple key distribution scheme wireless sensor networks enables securing entire network use two phases security implementations sensor nodes communicating recovery phenomena also stated time function due high energy consumption elsevier rights reserved
synchronous reluctance motor permanent magnet assisted synchronous reluctance motor assisted rated power level designed help finite element analysis fea performances levels compared shelf inverter fed variable speed cage induction motor surface mounted permanent magnet synchronous motor respectively comparison resulting average torque operating speed range torque ripple investigated two prototypes fabricated experimental measurements carried validate simulation data identified especially assisted permanent magnets compete induction motors even synchronous motors certain operating conditions
paper presents new hybrid modeling technique efficient simulation guided wave generation propagation interaction damage complex composite structures local finite element model deployed capture piezoelectric effects actuation dynamics transmitter global domain wave propagation interaction structural complexity structure features damage solved utilizing local interaction simulation approach hybrid approach allows accurate modeling local dynamics transducers keeping formulation explicit format facilitates readiness parallel computing global framework extended theory include anisotropic damping effects composite structures improvement existing formulation global framework implemented using compute unified device architecture running graphic processing units commercial integrated seamlessly computational framework grid generation material property allocation handle complex structures excitability damping effects successfully captured hybrid model experimental validation using scanning laser doppler demonstrate capability hybrid approach complex structures guided wave propagation interaction composite panel presented
work undertaken determine genesis role creativity formation mental qualities gave evolutionary advantages intra competition period bifurcation border middle upper creativity allowed design adaptive forms behavior corresponding conditions degree uncertainty create stable mental constructs absence perceptual sources require reactive behavior visualization target image originally applied instructional value process semantic filling transformed symbol getting qualities perceptual source connection primary value creation qualitatively new needs bilateral direct inverse relations system subject symbol ability produce prognostic hypothesis expansion operating range mind allowed ability search change tactics adaptive behavior gave results improvements quality life increase life expectancy genetically fixed intra competition emergence new operating systems including emergence development symbolic thought criterion creativity potential ability quantitative measurement propose value deviation creative oscillations proposal creative individual boundaries stereotypes cognition sphere deviation border social sphere acceptable
general synthesis procedure given versatile signal flow graph realization general transfer function using current differencing buffered amplifier proposed configuration uses capacitors resistors number resistors reduced special cases circuit eligible obtain variety transfer characteristics common polynomial easily converted different modes operations straightforward find values passive elements coefficients transfer function realized simulations results obtained using commercially available active component cmos technology make proposed circuit attractive elsevier gmbh rights reserved
whole process cost control project construction popular various reasons actual implementation become mere development information technology building information model entered practical stage domestic obtained good effect multiple projects get industry wide attention order promote whole process cost control introduce building information model project construction management analysis building information model different role various stages whole process cost control application different forms building information model difficulties whole process construction project cost control building information model application implementation reference value promotion whole process cost control
promote energy utilization efficiency internal combustion engine approach electronically controlled engine exhaust gas energy recovery investigated method test coupling numerical simulation first tests gasoline engine high speed motor conducted provide experimental data numerical simulation simulation model engine built calibrated working processes engine simulated results show recovered exhaust gas energy increases decrease pass valve opening due rising exhaust gas mass flow rate pumping loss also limited original engine map engine working points beyond turbine map pass valve opening increases certain degree improve energy recovery potential larger turbine working processes engine whole operating conditions results indicate engine exhaust gas energy recovered low load low speed area due low exhaust gas pressure effective working area load speed recovery efficiency utilization efficiency exhaust gas energy increase maximum values reach respectively demonstrate effectively recover engine exhaust gas energy
background data use surgical traditional largely debated several authors unfavorable use advent laparoscopic role discussed increased risk undetectable pancreatic gastric colon injury challenging laparoscopic removal spleen induced surgeons advantages related use methods one hundred seventeen consecutive cases laparoscopic routine use surgical reviewed indications surgery length operations post operative day drain removal post operative complications retrospectively analyzed results laparoscopic performed idiopathic patients lymphoma hereditary beta diseases cases conversion open surgery necessary cases removed days surgery within days within months cases cases post operative bleeding detected drainage required operation one patient myelofibrosis massive splenomegaly developed late post operative successfully treated percutaneous drainage conclusions authors experience use laparoscopic helped detect early post operative bleeding surgical reduce incidence fluid abdominal collections infections use recommended laparoscopic approach especially technically demanding surgical procedures
lower frequently exposed fracture accidents violence accidental falls sports injuries pathological fracture etc investigated behaviour mandibular bone particular clinical case fracture experimentally applied two plates analyzed effects loading fracture line finite element method observed case maximum deformations occur mandibular maximum minimum normal stresses occur plates even determine important efforts plates titanium alloy supports loads important aspect bone parts healing object excessive mechanical loads
introduction currently developing provision dermatology services epidemiologic studies skin diseases seen dermatologists needed guide efforts aimed describe skin conditions seen management practices dermatologists specialized clinic methods conducted chart review new patients presenting teaching hospital dermatology clinic results among patients studied discrete diagnoses made commonly diagnosed skin conditions infections dermatitis atopic dermatitis vulgaris common specific diagnoses among infants children adolescents common diagnosis atopic dermatitis respectively vulgaris common skin condition diagnosed young adults contact dermatitis common among adults commonly diagnosed skin condition senior population diagnoses made dermatologists differed referral diagnosis documented primary care providers patients frequently recommended treatments topical steroids diagnostic biopsies performed conclusion study summarizes skin diseases seen management practices dermatologists specialized clinic large public teaching hospital results study help guide future dermatology education development efforts
review recent studies early childhood followed report study development early childhood ages years terms childrens ability willingness help share preschool children interacting pairs matched age sex age appropriate structured task opportunities help share arose natural flow events results indicate even children age displayed acts number children showing number acts greater age level sharing common behavior frequent helping donation behaviors earlier ages possible explanations different developmental trajectories different acts discussed emphasis differing cognitive empathic demands situation main contributions study include demonstration different developmental trajectories different types acts age related increase spontaneous acts toward peers years age utility naturalistic structured observational task study spontaneous towards peers young children
obesity associated mood disorders depression anxiety aim study investigate whether exercise benefits mood disorder high fat diet induced obesity mice randomly divided four groups control control exercise high fat diet exercise obesity induced week exercise groups exercise performed times week weeks exercise duration intensity gradually increasing week intervals mice tested tail suspension elevated plus maze tasks order verify mood disorder like behavior depression anxiety obesity present study number cells expression hit protein decreased dorsal depression anxiety like behavior increased group compared con group contrast exercise ameliorated mood disorder like behavior induced obesity enhanced expression serotonergic system dorsal concluded exercise increases capacity serotonergic system dorsal improves mood disorders associated induced obesity
image based visual discomfort analysis strong potential detect order predict satisfaction space however order design buildings visual comfort mind architects need ability predict rather photographs paper compare measurements high dynamic range photographs computer space clear conditions order assess accurately architects predict though simulation use two ray tracing engines scenes mathematically defined model recorded outdoor levels photographs depending scene methods predict daylight probability levels due bright sources accuracy discomfort due contrast accuracy predictions sensitive modeling measurement accuracy simulation parameters accurate results come relatively fast simulations furthermore graphics acceleration able produce accurate predictions within minutes using achieving speedup times elsevier ltd rights reserved
purpose paper addresses evolution fuzzy systems core applications automotive engineering methods presented study based analysis dedicated fuzzy sets fuzzy control ground vehicles special attention given fuzzy approaches used following domains automotive engineering vehicle dynamics control systems driver driving environment identification comfort control energy management electric vehicles results analysis supplemented statistics relevant research publications allowed allocate important fuzzy application cases domain particular concerns driver identification human machine interface recognition road conditions controllers vehicle powertrain systems found fuzzy methods primary use tasks requiring identification forecasting procedures especially conditions limited informational space additional observation also derived presented survey points reasonable integration fuzzy technique control engineering methods improve performance automotive control systems conclusions aggregate performed review indicates fuzzy computing considered versatile tool automotive engineering applications different nature
background highly effective hepatitis virus hcv therapies scale treatment populations greater risk sustained response higher hiv hcv prior studies considered small selected populations assessed risk factors representative cohort canadian patients clinical care methods patients achieving hcv treatment followed hcv rna measurements every months prospective cohort study used bayesian cox regression estimate rates according patient reported injection drug use sexual activity among men sex men msm results patients treated hcv achieved least subsequent rna measurement person years follow became hcv rna positive adjusted rate per first year highest reported high frequency interval followed msm reporting high risk sexual activity low frequency rate low risk msm similar reference patients rates diminish time conclusions hcv rates varied according risk measures needed reduce risk behaviors increase monitoring high risk msm hcv elimination targets realized
causes premature ovarian failure result estrogen deficiency characterizing transition rodents equivalent menopause women menopause associated metabolic glucose intolerance insulin resistance glucocorticoids known exert effects thus aimed investigate whether rats premature ovarian failure prone effects immature female rats received daily injections body weight consecutive days whereas control rats received vehicle days completion administration rats divided groups received daily injections saline days received daily injections dexamethasone days treated group treated group experiments occurred one day last dexamethasone injection treated rats exhibited ovary reduced number premature ovarian failure impact body weight gain food intake reduced effects dexamethasone increase blood glucose plasma insulin levels reduction insulin sensitivity caused dexamethasone treatment exacerbated group rats premature ovarian failure change neither hepatic content glycogen glycerol release adipose tissue glucose intolerance observed group oral glucose challenge glucose intolerance compensatory pancreatic beta cell mass caused modified ovarian failure group conclude reduced ovarian function major implications effects promoted treatment indicating factors related aging make rats vulnerable side effects glucose metabolism elsevier ltd rights reserved
epidemiological studies demonstrated prevalence hypogonadism old males increases every additional decade life males present various symptoms including decrease sexual function decrease cognitive function altered lipid profile increased visceral adiposity changes bone density muscular strength secondary atrophy currently testosterone injections gel preparations used testosterone replacement therapy provides significant symptomatic improvements men late start hypogonadism long term benefits risks testosterone replacement therapy evident testosterone effects studied health related parameters prolonged period time large ongoing randomized clinical trial sponsored testosterone control old men low testosterone levels results give answers possible benefits risks testosterone replacement aging males aging male diagnosed late start hypogonadism discuss patient potential benefits risks testosterone therapy aging males significant untreated sleep apnea prostate cancer high risk cardiovascular events excluded testosterone replacement therapy currently enough evidences clearly state benefits testosterone replacement therapy aging males better risks treatment general recommendation given testosterone replacement therapy applied aging males low testosterone levels independently significant signs symptoms
design optimization data centers requires accurate mathematical modeling workloads describe statistical physics inspired formalism allows derivation state space representation network dynamic optimization
contemporary powerful mathematical software enables new approach handling manipulating complex mathematical expressions mathematical objects particularly use symbolic computation leads new contribution constructing analyzing numerical algorithms solving difficult problems applied mathematics scientific disciplines paper concerned problem determining multiple known advance task seldom considered literature use computer algebra system employ symbolic computation several programs construct investigate algorithms determine sought zero applying recurrent formula generating iterative methods higher order solving nonlinear equations construct iterative methods serve multiple zero given function order unknown simultaneously finding exact order particular state useful convergent iterative sequences find exact iteration steps approach combined rapidly convergent method multiple provides construction efficient composite algorithms finding multiple high accuracy properties proposed algorithms illustrated several numerical examples basins attraction elsevier rights reserved
aim work development characterization loaded nanoparticles evaluation potential antifungal activity fungal infection caused candida considered one major public health problem currently discovery antifungal agents present reduced null resistance candida development efficient drug release mechanisms necessary improvement treatment commercially available years exhibits antibacterial action food products potential antifungal activity among several alternatives used modulate antifungal activity polymeric nanoparticles received great attention due effective drug release control reduction therapeutic dose besides minimization adverse effects preferential accumulation specific tissues nanoparticles prepared double solvent evaporation methods nanoparticles characterized dynamic light scattering zeta potential fourier transform infrared ray diffraction differential scanning calorimetry scanning electron microscopy antifungal activity accessed plate method cell counting using candida albicans strains vitro release profile vitro studies performed using dialysis bag method pig vaginal mucosa diffusion cell respectively results revealed nanoparticles spherical shape high loading efficiency vitro test results suggest promising application prophylactic agent recurrent diseases
introduction prevalence morbidity eating disorders high patients bipolar disorder simple tools necessary easily rapidly screen bipolar patients objective aim study validate french version bipolar eating disorder scale beds method diagnoses established structured interview patients according dsm criteria beds translated french using appropriate methods patients administered following scales beds test eating disorder inventory two results beds score significantly higher bipolar patients beds showed high feasibility response excellent discriminating abilities roc auc specificity beds high internal consistency cronbachs alpha coefficient test retest reliability icc floor effect observed beds sensitivity equivalent subscale beds specificity slightly lower subscale equivalent conclusion beds valid scale fast screening patients bipolar disorder easier currently used scales elsevier masson sas rights reserved
drug substance primarily indicated treatment absence seizures drug used clinically human urinary metabolites studied using gas chromatography gas chromatography mass spectrometry metabolites identified previously reported unchanged four methyl four ethyl hydroxy iii chemical methodology using electron impact ionization chemical ionization techniques two previously metabolite ethyl identified copyright john wiley sons ltd
biomarkers diagnosis alzheimers disease yet validated use clinical settings aim provide methodological framework systematic validation reference developed oncology biomarkers discipline steps systematic validation biomarkers need target analytical validity clinical validity clinical utility however different oncology nature disease neurodegeneration cancer purpose improve diagnosis clinically affected screening preclinical individuals target population mild cognitive impairment patients referring memory clinics general population lead important differences influencing design validation studies use selected biomarkers framework applied within wider initiative assess current available evidence clinical validity biomarkers final aim identify gaps research priorities inform coordinated research efforts boosting biomarkers research elsevier inc rights reserved
paper integrated numerical model established solve complex energy transfer parabolic trough collector combining monte carlo ray tracing finite volume method based model thermal performance using supercritical heat transfer fluid studied analyzed results indicate solar fluxes receiver walls non uniform results non uniform temperatures walls moreover optical efficiency achieved normal incidence temperature difference delta absorber found within typical conditions decreases increasing inlet velocity decreasing inlet temperature studies flow heat transfer characteristic indicate secondary flow occurs cross section due velocity secondary flow pseudo critical region one magnitude order larger high temperature region leads strong heat transfer enhancement former studies energy conversion performance indicate achieve collector efficiencies typical conditions rankine cycles respectively efficiency increases decreasing tin increasing additionally corresponding efficiency equations also obtained information study provide reference design operation using elsevier ltd rights reserved
objectives evaluate changes time drug use among patients undergoing gastric bypass surgery matched population based comparison cohort background little known prescription drug use surgery methods nationwide population based cohort study included patients undergoing denmark matched general population members calculated prevalence ratios comparing prescription drug use months index date use months date baseline results baseline patients median years males used prescription drug years use decreased slightly among patients confidence interval increased comparison cohort cohort large sustained decreases occurred treatment metabolic syndrome related conditions glucose lowering drug lipid modifying drugs use obstructive airway diseases also decreased use neuropsychiatric drugs two fold higher baseline cohort increased antidepressants antipsychotics potential treatment neuropathy conclusions three years surgery found large reductions use treatment metabolic syndrome related conditions obstructive airway diseases glucocorticoid use contrast frequent use neuropsychiatric drugs increased
paper poses problem physical construction sets example geometry construction set provides small number different types building blocks example model many similar variants process core contribution approach simplifying obtain physically building blocks controllable granularity retaining variability ability construct many different related shapes simplification performed sequences two types elementary operations non local joint edge graphs reduce granularity decomposition approximate replacement operations reduce redundancy evaluate method abstract graph addition computing several physical construction sets manufactured using commodity
immune expected crucial survival considerable parasite pressures experienced wild animals however understanding association immunity fitness nature remains limited due complexity vertebrate immune system often limited availability immune reagents organisms use methods reagents developed veterinary researchers domestic blood samples collected wild sheep population evaluate broad panel immune parameters evaluation included different innate acquired immune cell types parasite specific antibodies different test markers correlate one another vary age group sex whether predict winter survival either within among demographic groups found anticipated patterns variation markers age associated immune development age trends accounted correlations among immune markers generally weak found females higher proportions naive cells gamma delta cells males independent age markers differ sexes one markers predicted survival sheep higher plasma levels anti igg antibodies significantly likely survive subsequent high mortality winter independent age sex weight supports previous finding study system using different set samples shows circulating antibody levels ecologically relevant parasites natural systems represent important parameter immune function strong natural selection data provide rare insights patterns variation among age sex groups different cell subsets antibody levels wild suggest certain types immune response notably likely within individuals linked resistance ecologically relevant parasites informative research links immunity fitness natural conditions
estimating observation error covariance matrix properly key step towards successful seismic history matching typically observation errors seismic data spatially correlated therefore observation error covariance matrix non estimating non covariance matrix focus current study decompose estimation two steps estimate observation errors construct covariance matrix based estimated observation errors focus step whereas step use procedure similar step carried using local moving average algorithm treating seismic data image algorithm interpreted discrete image rectangular window function following perspective image processing consider three types image methods namely local moving average different window functions extension method non local means wavelet performance three algorithms compared using synthetic field seismic data found investigated cases wavelet method leads best performance time
age become increasingly susceptible memory distortions past decade numerous neuroimaging studies attempted illuminate neural underpinnings aging false memory review studies link findings concerning cognitive properties age related changes memory accuracy collectively evidence points towards prominent role age related declines medial temporal prefrontal brain areas corresponding impairments associative binding strategic monitoring resulting cascade cognitive changes contributes heightened vulnerability false memories age including reduced ability reliance information familiarity based monitoring mechanisms reduced ability inhibit irrelevant information erroneous binding features memory traces consider theoretical applied implications research aging false memories questions remaining addressed future research elsevier ltd rights reserved
pendulum simple system usually related great discoveries science technology nonlinear dynamics pendulum systems related variety responses objective studies oscillations chaos smart material nonlinear effects employed several applications due adaptive behavior presenting great advantages control strategies work deals dynamics sma pendulum system consists pendulum coupled shape memory alloy springs numerical investigation carried exploiting temperature dependent behavior sma complex responses presented possibility thermal control system investigated
disruption neuronal morphology contributes pathology neurodegenerative disorders alzheimers disease however underlying molecular mechanisms unknown show postnatal deletion cofactor promoting complex ubiquitin neurons conditional knockout causes dendritic spine synapse loss cortex hippocampus concomitant memory impairment neurodegeneration adult mice found rho protein kinase brain patients substrate vivo protein activity increased cortex hippocampus mice animals inhibition rock activity using clinically approved drug prevented dendritic network memory loss neurodegeneration thus mediated degradation maintains dendritic network memory formation neuronal survival suggesting pharmacological inhibition accumulated suitable therapeutic strategy neurodegeneration
paper discusses application connected pipe system suspension bridge china purpose vertical deflection monitoring assessment mainly consists three main parts pressure detect height change liquid pipes connect reference point measurement points liquid fill connected pipes multiple pressure taken measurement point mounted inside girder reference transmitter mounted inside tower taken fixed point verify performance reliability controlled load test completion bridge construction uncontrolled load test actual traffic loading carried results showed exhibited excellent capability real time measurement vertical deflection suspension bridge long term deflection data monitored extreme respect vehicle loads predicted extreme value analysis generalized extreme value distribution adopted establish probability models daily maximum minimum deflection sequences extreme within design reference period determined based probability models comparison extreme deflection thresholds carried deflection monitoring assessment method proposed paper shown high potential applicability practice health monitoring long span bridges copyright john wiley sons ltd
introduction seasonal affective disorder sad psychiatric illness depressive episodes particular seasons mostly winter effective preventive treatment sad probably also effective acute treatment sad areas covered review covers pharmacokinetics authors also evaluate clinical efficacy safety tolerability expert opinion available immediate release formulation sustained release formulation extended release formulation formulation recommended sad due ease use formulation currently used therapy due predictable nature sad use considered relevant treatment option efficacy shown three trials started autumn time sad symptoms yet present although treatment effects relatively small compared placebo also shown efficacy open label study said order reach definitive conclusions efficacy acute treatment sad placebo controlled trials needed
objective hypersensitivity reactions frequently reported patients recurrent ovarian cancer roc represent critical issue since discontinuation platinum based therapy affect prognosis several strategies allow platinum described controversial outcomes aim study illustrate year experience patients previous risk allergy methods retrospective review patients platinum sensitive roc performed january results among patients presented mainly second line therapy mean number cycles range reaction detected patients respectively multivariate analysis including age status previous known combination drug administered type based used line therapy found significantly affect development protective effect doxorubicin thirty seven patients previous treatment generally tolerated patients experienced mild successfully managed cases patients treated even without related due allergies among one developed conclusions feasible approach patients experiencing maintain beneficial effect platinum reducing hypersensitivity related risks elsevier inc rights reserved
standard fractional order continuous time systems piecewise constant inputs addressed necessary sufficient conditions existence piecewise constant inputs system zero initial conditions given final state desired time derived proved examples systems electrical circuits switched voltage sources presented
increasing evidence indicates patients chronic inflammatory arthritis including rheumatoid arthritis increased risk events significantly contributing higher cardiovascular disease cvd morbidity mortality observed subjects compared general population although mechanisms accounting substrate fully understood main role probably played chronic systemic inflammation able accelerate development structural cvd directly affect cardiac electrophysiology past decade biologic therapies revolutionized treatment highly enhancing probability effectively control disease activity systemic consequences including cardiovascular involvement accordingly accumulating data demonstrated inhibiting systemic inflammation biologic drugs reduce cvd progression ameliorate risk parameters putative beneficial impact arrhythmia incidence nevertheless significant number reports clinical trials experience suggest medications particularly tnf inhibitor monoclonal antibodies rituximab circumstances arrhythmia occurrence probably acutely myocardial electric instability intrinsically associated diseases review analyze intricate link biologic drugs arrhythmias effort identify factors involved fine tuning pro balance understand knowledge translated clinical practice obtain favorable benefit risk profile biologic drugs used patients
order improve safe level network security fuzzy neutral network applied optimal attack defense decision firstly theory model attack defense decision system network security based game theory constructed game model attack defense model dynamical game model incomplete information deduced respectively secondly basic theory fuzzy neutral network analyzed framework diagram fuzzy neutral network confirmed model fuzzy membership function constructed training algorithm fuzzy neutral network based improved genetic algorithm designed computing method every step given detail evaluation person system carried finally simulation experiments carried results show system profit response efficiency improved fuzzy neutral network obtain higher system profit response efficiency
vivo vitro tests two major ways identifying triggering allergens sensitized individuals allergic symptoms methods equally significant terms sensitivity specificity however certain circumstances vitro methods highly preferred circumvent use drugs patients current study described highly sensitive immuno pcr assay serum ige specific allergens using oligonucleotide labelled antibody used sensitive detection serum ige nucleotide sequence amplified using conventional pcr bands visualized gel results demonstrated fold enhancement sensitivity commercially available enzyme linked immunosorbent assay elisa kit method highly sensitive specific serum ige beneficial allergy clinics elsevier ltd rights reserved
myeloproliferative neoplasms mpns diseases excess cell proliferation bone marrow precursors two classic mpns polycythemia vera essential conditions excess proliferation red blood cells platelets respectively although involve different cells myeloid lineage clinical presentations shared features consistent overlapping mutations growth factor signaling management diseases involves minimizing risk thrombotic hemorrhagic complications progress myelofibrosis acute myeloid leukemia poor prognosis mpns also present primary myelofibrosis
exposure air pollution claimed lives seven million people worldwide largely combustion solid biomass fuels alternative renewable source mitigate climate change little known human health ecosystem effects mainly electricity sector research applied life cycle assessment approach examine human health ecosystem effects four pathways direct combustion wood biomass direct combustion forest residue direct combustion biomass integrated combined cycle pathways showed variability impacts therefore single pathway best absolute option exception slightly higher human health impact least impact impact categories however systems implied lower ecosystem impact higher human health impact compared climate change impact electricity generation wood biomass improve environmental sustainability electricity grid system reduces human health ecosystem impacts compared existing electricity production mix province elsevier ltd rights reserved
wireless network security becoming great challenge popularity high account open medium insignificant software implementation potential hardware deficits configuration network vulnerable access point access point access point installed end users without knowledge security device connected internet used security network existing detection techniques limited capabilities able detect variants activities paper method named intrusion detection system ids proposed detection prevention access point via attack detection performed internal external malicious users ids combines intrusion detection system reduce false alarm rate generated existing ids proposed approach consist three phases filtering intrusion detection system traffic passing filtering intrusion detection system depth investigation proposed architecture improves overall performance system false alarm rate generated intrusion detection system able sustain overall workload
models humans commonly used within computer graphics vision ability distinguish body shapes important shape retrieval problem extend recent paper provided benchmark testing non rigid shape retrieval algorithms human models benchmark provided far challenge previous shape benchmarks added new models use separate training set order training data used provide comparison also included experiments dataset human scans participants previous benchmark study taken part new tests reported many providing updated results using new data addition participants also taken part provide extra analysis retrieval results total different shape retrieval methods compared
fluid mechanics simpler fluid mechanics macroscopic systems macroscopic systems effects non laminar flow convection gravity etc need accounted usually neglected microfluidic systems still exists limited selection channel cross sections navier stokes equation pressure driven flow solved analytically equations velocity profiles flow rates calculated however whenever cross section highly symmetric rectangular circular navier stokes equation usually solved analytically cases numerical methods required however many instances necessary turn complex numerical solver packages deriving velocity profile complex microfluidic channel cross section paper simple analysis tool microsoft used implement simple numerical scheme allows solving navier stokes equation arbitrary channel cross sections
teaching approach goal help students overcome learning difficulties transition entry level advanced computer programming prepare real world labour environments adopting learning strategies learners learning environment students develop problem based learning activity specific set tasks one filling weekly individual forms conducted thematic analysis weekly forms identify students strategies self regulation learning assignment students adopting different strategies phase approach early phases devoted organization planning later phases focus applying theoretical knowledge hands programming based results recommend development educational practices help students conduct self reflection performance tasks
ideology proposes group just acknowledged also valued order accommodate diversity attain equality three studies conducted spain canada analyzed using different measures relationship ideology one hand prejudice support social policies motivation social change hand spain focused responses spanish canada first nations people results showed ideology related cases lower prejudice higher support social policies support minority group motivation social change internal motivation control prejudice important mediator relationship countries contrast way social identities represented played different role function country whereas dual identity representation played mediating role canada common identity representation mediator spain results support importance cultural diversity intergroup relations reduce inequalities minority groups elsevier ltd rights reserved
study investigated whether use thought control strategies specific suicidal thoughts influenced suicide ideation suicide risk sample adult students selectively recruited history suicide ideation pre screen assessment adapted version thought control questionnaire wells specific controlling thoughts suicide employed assess whether participants responded thoughts suicide worry self punishment distraction suicide specific thought control questionnaire demonstrated reliable factor structure similar original measure results indicated distraction suicidal thoughts negatively correlated suicide ideation risk whereas self punishment thoughts thoughts positively correlated suicide ideation suicide risk clinical implications future research directions discussed elsevier ltd rights reserved
permanent magnet motors rare earth magnets among best candidates high performance applications automotive applications however due cost risks relating security supply alternative solutions magnets recently become popular paper two major design challenges using magnets high torque density high speed application low flux density low addressed shown type design utilizing distributed winding overcome torque density challenge due simultaneous flux concentration reluctance torque possibility furthermore challenge overcome careful optimization rotor structure inclusion top bottom magnets meet challenges high speed operation extensive rotor structural analysis undertaken manufacturing taken account electromagnetic studies validated testing prototype custom built static torque evaluation disclosed motor design state art performance cost merging theories multidisciplinary product
present work biosensor built smart material based polymer biosensor demonstrated sensitive property used control modulate electrochemical responses biosensor property used realize controlled electrochemical reaction hydrogen peroxide immobilized polymer composite film also showed excellent response toward hydrogen peroxide concentration range future platform used self regulating targeted diagnostic drug delivery cell based controllable elsevier rights reserved
french people consumed nearly billion worth drugs resulting growing burden french social security expenses public health insurance amount billion total cost drug purchase french authorities point need rational prescribing especially concerning psychotropic drugs data prescription second generation antidepressants synthesized clinicians use objective study offer description effectiveness tolerability acceptability according data recent meta analyzes method searched latest meta analysis medline present web science present cochrane journals results considering benefit risk ratio cost generic first line treatment major depressive episode currently day however digestive side effects due serotonin action calls caution increasing doses four effective antidepressants order show better acceptability profile seems relevant treatment negative symptoms schizophrenia day bulimia day seems relevant case sexual side effects previous treatment anxiety disorders affinity sigma receptors confer specific action psychotic depression treatment interest fast remission depressive symptoms warranted tolerance profile makes difficult use found meta analysis comparing efficacy tolerability antidepressants probably due recent availability molecule found arguments favor first prescription except perhaps better safety profile data scarce presence generalized anxiety disorder indication start treatment half doses days molecule avoid anxious symptomatology prescription antidepressants demonstrated efficacy major depressive episode anxiety disorders molecules seasonal affective disorder sad efficiency explain prescription antidepressants exceed scope marketing conclusion summarize article current data recent meta analyzes regarding effectiveness tolerance acceptability help practitioners choices prescription elsevier masson sas rights reserved
family proteins parasitic combine terminal hand domains terminal light chain like domains data accumulating biochemistry cell biology proteins however little known functions vivo expresses family members three subjected biochemical analysis demonstrated different molecular properties although overall folds predicted similar small changes hand domains result differences ion binding properties whereas able bind calcium ions appears unable bind similar biochemical diversity seen proteins four family members known bind calcium ions however presence calcium ions absence calcium ions regardless prevailing calcium ion concentration families proteins also differ ability bind antagonists related drugs interestingly interacts drug choice treating pharmacological significance finding unknown
homolog enzyme participates process dna damage oxidized cancer cells regarded potential target anticancer therapy order seek promising inhibitor structured based hypotheses combine analysis rule five used screening public molecules libraries natural molecular docking studies performed screened via various docking programs gold five molecules three scaffolds potential inhibitors eventually molecular dynamics simulation implemented potential inhibitors root mean square deviation values used illustrate bind stability potential molecules therefore five considered promising inhibitors studies elsevier rights reserved
based primary care provides patients care plan individually tailored manage multiple chronic conditions functional limitations using variety resources examine visit volume medicare residence based health care provided nurse practitioners nps medicare fee service environment compare nps residential visits family physicians compare geographical service area full time house call nps versus nps make nursing facility visits major portion work observational study using secondary data provider utilization payment data beneficiaries home care visits number residence based medical visits provider volume geographical distribution full time house call providers nps performed million home care visits accounting residential visits medicare fee service beneficiaries total nps individually made residential visits defined full time house call provider among full time house call providers including physicians nps now common provider type substantial variations geographic distribution full time house call nps family physicians full time nps service area larger family physicians nursing home residents far likely receive visits persons receiving home visits now largest type provider delivering residence based care nps provide care largest geographical service area however vast majority americans likely receive nps care nursing facility versus home
effects violent video game exposure youth aggression remain issue significant controversy debate yet clear whether violent video games uniquely contribute long term youth aggression whether relationship better explained third variables aggressive personality family environment current study examines influence violent video game exposure bullying behavior grade students variables parental involvement trait aggression stress participation activities family peer support also considered results indicated bullying behavior predicted childs trait aggression stress level violent video game exposure found predictive bullying level parental involvement results question commonly held belief violent video games related youth bullying
dna nanotechnology enables synthesis nanometer sized objects site specifically functionalized large variety materials reasons dna based devices dna considered applications molecular biology however many dna structures need higher ionic strength common cell culture bodily fluids maintain integrity degraded quickly overcome deficiencies coated several different dna structures cationic poly ethylene glycol block covered dna nanostructures form dna straightforward cost effective robust route protect dna based structures therefore enable applications biology unprotected dna degraded
paper presents design performance details electric propulsion system propulsion system two machines one machine operating mostly motor machine operating mostly generator machines electric drive system permanent magnet synchronous machine types magnets buried inside rotor motor distributed windings however opposed conventional stranded winding motor bar wound construction improve motor performance particularly low medium speed range higher speed skin proximity effects stator bars lead increased stator winding losses addressed design bar wound construction also excellent thermal performance steady state transient conditions necessary full electric vehicle driving generator uses concentrated windings concentrated winding construction good slot fill short end turn length features resulted good performance intended operational region machine packaging inside transmission machines exhibit excellent efficiency smooth operation machine design construction details measured thermal electromagnetic acoustic noise performances presented paper
antimicrobial resistance pathogenic gram negative bacteria one pressing challenges field infectious diseases one key areas unmet medical need identified antibacterial resistance leadership group mission gram negative committee advance knowledge challenging infections implement studies improve patient outcomes studies primarily broad categories prospective cohort studies interventional trials among observational studies consortium resistance contributed multicenter data describing risk factors clinical outcomes resistant cre hospitals building success expand network hospitals across united states similar protocols proposed include pseudomonas aeruginosa studies addition crest study resistant solid organ transplant patients provided pivotal data extended spectrum beta producing cre among solid organ transplant recipients inform management vulnerable patient population two clinical trials define novel ways using existing antibiotic treat producing one completed enrollment late protocol development determine clinical efficacy step oral therapy treat complicated urinary tract infections additional clinical studies trials using newly approved agents also planning stage main goals generating data inform clinical decision making facilitate development new treatment options highly resistant gram negative bacterial infections
act wait concept recently developed type controller receiving growing interest promising features respect control systems feedback delay although advantages widely discussed verified experimentally detailed analysis nonlinear behavior type controller still missing paper apply act wait controller digital position control single degree freedom system analysis shows linear stability post bifurcation behavior system comparing system regular proportional differential controller act wait controller performed investigation confirms advantages act wait controller already known literature regarding enlargement stable region possibility achieving control also presence delay hand shows drawbacks controller related post bifurcation behavior presents motions robustness stability appears limited
subspace learning methods feature selection methods often used removing features high dimensional data studies shown feature selection methods interpretation ability subspace learning methods output stable performance paper proposes new unsupervised feature selection integrating subspace learning method locality preserving projection new feature selection method sparse feature level self representation method aim simultaneously receiving stable performance interpretation ability different traditional sample level self representation sample represented samples used machine learning computer vision paper propose represent feature relevant features conduct feature selection via feature level self representation loss function plus norm regularization term add graph regularization term resulting feature selection model simultaneously conduct feature selection subspace learning rationale regularization term preserves original distribution data removing features finally conducted experiments data sets real data sets experimental results showed proposed approach outperformed comparison algorithms elsevier rights reserved
present scalable computing framework solution stochastic multiobjective optimization problems proposed framework uses nested conditional value risk metric find compromise solutions among conflicting random objectives prove associated minimization problem cast standard stochastic programming problem expected value linking constraints also show problems implemented modular compact manner using based structured modeling framework solved efficiently using parallel nonlinear solver apply framework design study seek find compromise solutions trade cost water emissions face uncertainty electricity water demands elsevier ltd rights reserved
green building shown great advantage promoting economic efficiency however also exposed problems developing process among matter industrial chain stability vital one article employing theory differential stability analyses composition green building industrial chain system types firm basis study eco industrial chain logistic model enterprises growth described different relationship analyzed stability
current development trends regarding mobile electrical generator sets indicate enhancement efficiency sought means operate driving engine either diesel gasoline continuously optimum speed engine generator dynamics sudden load change low load high load remains challenge regard dynamic behavior analysis presented proves introduction energy storage element variable engine speed concept eliminates drawback paper addresses identification dynamic behavior variable speed systems problems encountered sudden increase load power voltage drops
major advances memory past decade now allow investigators efficiently detect analyze many types sophisticated kernel level operating systems now routinely driver integrating strategies protecting kernel data patch attacks becoming attractive authors evidenced crisis therefore turn attention improving memory techniques analysis paper focus new methods detecting written objective mac paper illustrates objective provides rich set use manipulate application data perform malicious activities novel memory techniques deeply examine state objective runtime inside targeted processes identifying number activities examine techniques memory samples infected found targeted attacks authors published elsevier ltd
background many years conventional double contrast suggested technique choice evaluation small intestine computed tomography performed oral intravenous contrast material proven track record depicting bowel wall abnormalities developed overcome individual deficiencies conventional combine advantages conventional abdominal examinations one technique present study longitudinal study evaluate role multi detector row helical computed small bowel diseases patients aim study prospectively evaluate role multi detector row helical computed small bowel diseases materials methods study group done clinically suspected cases small bowel diseases referred department medical college october september results patients underwent successful positive findings obtained patients negative findings obtained patients among patients allowed detection small bowel masses patients including adenocarcinoma gastrointestinal stromal tumour lymphoma demonstrated metastatic lymph nodes cases small bowel abnormalities patients including patients crohns disease patients small bowel tuberculosis images demonstrated site cause small bowel obstruction cases areas stenosis cases inflammatory changes conclusion fast tolerated reliable imaging modality small bowel diseases technique provides adequate small bowel majority patients addition allows detection disease provides information relative entire abdomen obtained small bowel follow endoscopy
investigated regulatory activity human adipose derived mesenchymal stromal cells mscs towards immune cells cohort rheumatoid arthritis patients apparently healthy controls cultured mscs lymphocyte subsets regulatory cells levels pro anti inflammatory markers tumor necrosis factor alpha tnf alpha interferon gamma gamma interleukin estimated serum culture supernatants study revealed two fold increase proportion increased level mscs altered cell cell treg cytokine production anti inflammatory immune response mscs inhibited cell mediated alpha secretion upregulated suppressed production autoantibodies protein antigens produced cells data offer insight interactions allogeneic mscs immune cells elucidate dose dependent modulation mscs elsevier inc rights reserved
objectives chronic migraine prevalent devastating disorder limited therapeutic options study explored efficacy prophylaxis compared methods conducted prospective randomized open label blinded endpoint trial patients randomized treatment primary outcomes assessed reductions total numbers headache days migraine days weeks treatment secondary outcomes reductions numbers days acute medication intake acute medication tablets taken rate results sixty two subjects randomized group patients treated showed significant reductions numbers total headache days migraine days compared treated patients treated also showed significant reductions numbers days acute medication intake acute medication tablets taken higher rate terms total headache days migraine days compared treated patients generally tolerated safety profile comparable conclusions results suggest week study effective prophylaxis
quality products competitive advantage small software development organizations usage software systems engineering standards amongst small organizations extremely low key factor literature explaining lack quality standards adoption perception small small organizations standards developed large multi national companies small small organizations mind iso iec standard unique amongst software systems engineering standards working group iso iec mandated develop new standard approached industry conduct needs assessment gather actual requirements new standard part standards development process paper presents historical perspective behind development iso iec systems software engineering standard constituent components including rationale behind development innovative design implementation guides assist small companies adopting standards paper present overview various parts iso iec family briefly present plans future evolution series standards
increase intelligent devices ubiquitous computing spreading people life smart home industrial environments include automation control devices save energy perform tasks assist give comfort order satisfy specific preferences paper focuses proposal software reference architecture development smart applications deployment smart environments motivation reference architecture benefits also explained proposal considers three main processes software architecture applications perception reasoning acting paper centres attention definition perception process provides example implementation subsequent validation proposal software presented implements perception process smart environment standard office retrieving data real world storing reasoning acting processes objectives solution include provision comfort users saving energy lighting verification also shown developments proposal produce major benefits within software life cycle elsevier rights reserved
acetyl inhibitors approved fda first line drugs treat cognitive symptoms alzheimers disease beneficial effects attributed ability endogenous acetylcholine receptor brain however side effects nausea vomiting dizziness insomnia loss appetite altered heart rate related non specific activation subtypes various tissues logical therefore develop agonists receptor selectivity unfortunately limited due high degree site homology among receptor subtypes contrast sites unique therefore allow selective targeting using positive modulators receptors devoid agonist activity however bound enhance binding affinity ligand major limitation bioavailability brain current hypothesis propose surface modified nano lipid drug conjugates nps receptors improve bioavailability brain administered inhibitors expected increase efficacy reduce therapeutic dose side effects elsevier ltd rights reserved
november general subsequent voting college resulted selection united states incoming administration campaign indicated desire substantial change health policy including affordable care act said little directly hiv programs policies campaign positions clearly substantially impact lives persons living hiv highlight important hiv related goals underscore several key points evidence based advocacy important revisit time especially change administration
peripheral neuronal activation inflammatory mediators multifaceted physiological response involves multitude regulated cellular functions one key pathway shown involved inflammatory pain whose activation inflammatory mediators followed regulated response cation channel transient receptor potential however mechanism underlies activation downstream pathway yet fully defined study employ pharmacological molecular biology tools dissect activation mechanism via patch recordings calcium imaging neurons system showed activity downstream activation produced current different robust current typical activation exogenous stimuli moreover specifically demonstrated pathways downstream signaling namely production channel phosphorylation converge tightly regulated response importance show pathways acting inflammatory mediated response achieved propose requirement multiple signaling events allows activation regulated neuronal response inflammation activation transient receptor potential metabolites depends phosphorylation
district heating southern europe relevant energy sector improved terms efficiency monitoring systems without investments cost heat losses poor technical conditions combined high operational costs seriously affect competitiveness paper analyses combined heat power plant coupled located central italy explores possible solutions improve efficiency first plant described main features effects operation produced reduction supply water temperature highlighted lifetime put evidence low present energy market order overcome introduction internal combustion engine high temperature heat pump thermal energy storage tank existing system analysed results show best option new gas engine sized thermal demand allowing improvement primary energy saving configuration heat pump instead affects positively energetic efficiency opposite obtained elsevier ltd rights reserved
life expectancy increased many countries result worlds population aging projections indicate proportion elderly decades increase significantly aging carries series physiological changes one imbalance system thus levels activity various proteins involved coagulation factors natural anticoagulants system altered balance toward thrombosis also platelet activity suggests state abnormal activation beta platelet factor review systematically examine alterations components occur aging therefore understanding changes contribute developing strategies proper management health old age elsevier ireland ltd rights reserved
background serotonin key modulatory neurotransmitter mammalian central nervous system cns plays important role developmental signal several lines evidence associate altered signaling psychopathology humans particularly neurodevelopmental disorders autism spectrum disorders asd asd characterized persistent social communication deficits along repetitive patterns behavior symptoms emerging early development methods employed mouse model devoid brain due lack gene encoding tryptophan hydroxylase initial rate limiting enzyme synthesis cns null mutant mice show normal prenatal development however display yet unknown reasons severe growth retardation first postnatal weeks investigated therefore whether mice display deficits isolation induced ultrasonic pups early life isolation induced commonly studied behavioral measure assess developmental delays communication deficits rodent models asd particularly serve important communicative function coordinating mother interactions results mouse pups displayed clear deficit emission isolation induced compared heterozygous exactly growth retardation onset including reduced call numbers deficits call clustering temporal organization conclusions ultrasonic communication impairment displayed mouse pups likely result deficient mother infant interaction presumably contributing growth retardation phenotype represents prominent feature relevant asd
using narrative approach explored gaps parent child relationships conflict intergenerational conflict identity conflict sample immigrant canadian emerging adults findings revealed perceived gaps occurred intergenerational conflict theme identity conflict theme furthermore parent emerging adult relationship observed play role occurrence perceived gaps conflict specifically participants described strong parent emerging adult relationships minimizing occurrence perceived gaps intergenerational conflict theme perceived gaps identity conflict theme hand participants described weak parent emerging adult relationships occurrence perceived gaps intergenerational conflict theme perceived gaps identity conflict theme presented analyses using thick rich data extracts participants
decades research demonstrated physical stress stimulates bone remodeling affects bone structure function complex mechanisms recent research laid ground hypothesis mental stress also influences bone biology eventually leading osteoporosis increased bone fracture risk effects likely exerted modulation hypothalamic axis activity resulting altered release growth hormones glucocorticoids cytokines demonstrated human animal studies furthermore molecular cross talk mental thought exist either synergistic preventative effects bone disease progression depending characteristics applied stressor mini review explain emerging concept important player bone adaptation potential cross talk summarizing current state knowledge highlighting newly evolving notions intergenerational transmission stress epigenetic modifications affecting bone proposing new research directions
study designed investigate developmental changes true false memories detect links among middle childhood participants italian children years males divided two age groups hearing story children provided free recall true false retrieved information measured children repeatedly asked true misleading questions story recall measured finally children recalled story assess post event misinformation effect suggested information individual differences fluid intelligence working memory executive functions also assessed investigate relationships true false memories typical age effects found memory recall interesting links among true spontaneous suggested false memories found finally analyses reveal existence relationship cognitive functioning
transportation inevitable poultry industry induce stress varying degrees mild discomfort sometimes even death however research effects transport stress weight loss heart injury lacking elucidate underlying mechanism transport stress induced effects transported creatinine kinase activities ionic contents activities transcription atpase associated subunits heart detected results showed transport stress increased weight loss activity disturbed ionic homeostasis inhibited atpase atpase atpase atpase atpase activities increased atp content downregulated gene expression levels atpase associated subunits heart conclusion transport stress disturbed ionic homeostasis via modulating ion associated subunits ultimately induced weight loss heart injury
kinase catalyzes phosphorylation several analogs overexpressed purified two known isoforms human escherichia coli produced specific antibody characterized kinetic properties max purified recombinant fold higher respectively compared observed purified recombinant enzyme fold higher respectively compared observed purified recombinant enzyme antibody showed cross reactivity data showed expressed several neuroblastoma cell lines including four single copy cell lines five amplified cell lines exception expressed results indicate neuroblastoma used selective target chemotherapy using dependent analogues
pass networks prescribed group delay used analog signal processing transmission channels state art methods synthesizing quasi arbitrary group delay functions using pass elements lack theoretical synthesis procedure guarantees minimum order networks present analytically based solution problem produces pass network response required group delay within arbitrary error first time method shown work physical realization second order pass elements guaranteed converge global optimum solution without choice seed values input allows synthesis pre defined networks described analytically numerically proposed method also demonstrated reducing delay variation practical system desired amount compared state art methods comparison examples
model unsteady evolution turbulent following temporal changes source conditions integral model derived radial integration governing equations expressing evolution mass axial momentum non uniform radial profiles axial velocity density deficit explicitly captured shape factors integral equations commonly assumed top profiles lead shape factors equal unity resultant model unsteady hyperbolic momentum shape factor determined radial profile mean axial velocity differs unity solutions model source conditions maintained constant values shown retain form established steady solutions demonstrate linear stability analysis steady solutions inclusion momentum shape factor governing equations differs unity leads posed integral model therefore model exhibit mathematical pathologies appear previously proposed unsteady integral models turbulent stability threshold value shape factor also identified resulting range values amplitudes small perturbations steady solutions decay distance source hyperbolic character system equations allows formation fields describing properties unsteady evolution compute numerical solutions illustrate transient development following change source conditions adjustment new source conditions occurs propagation pulse fluid dynamics pulse described similarity solution construction new similarity solution identify three regimes evolution transient pulse following adjustment source qualitatively differs
emotional dysregulation explored mediator relationship perceived father rejection young adult male female aggression among undergraduate college students emotional dysregulation assessed combined construct distinct components analyses revealed impulsivity mediated relationship perceived father rejection aggression males females emotions partially supported mediator perceived father rejection aggression relationship among males females results suggest although father child relationships contribute variety emotion regulation difficulties impulsivity play integral role development aggression researchers clinicians encouraged pay particular attention process impulsivity influence aggression father rejected sons additional attention emotions sons limitations future research recommendations discussed
vivo metabolism study humans carried investigate metabolism sodium differentiating selenium status therefore changes blood plasma concentration urinary excretion within seven healthy subjects oral administration dietary supplement containing sodium selenium analyzed three subjects belong subgroup four subjects related non subgroup concentrations total selenium blood plasma urine samples determined coupled plasma mass spectrometry additionally analysis urine samples performed using coupled liquid chromatography system plasma selenium concentration changed supplementation considering individual hour background amounts renal excreted selenium ingestion caused additional excretion cap administered dose maximum elimination already exposure differentiated analysis revealed subjects main elimination product administered dose detected urine subgroup excreted comparison non significantly lower amount one subject metabolized larger portion methyl beta methyl amino beta subjects showed minor metabolism selenium containing carbohydrates individuals urine basically metabolized marginally excreted rapidly via urine generally contrast considerable portion inorganic selenium compound metabolized individuals eliminate basically elevated metabolism also provided individuals eliminate high levels selenium containing carbohydrates basically difference metabolism imply different disposition pharmacological toxic effects exposure inorganic selenium compounds
ambient intelligence ami paradigm applied healthcare sector promising solution develop software based systems capable supporting medical procedures activities carried close high regulated complex healthcare environment ami healthcare system ami impact health life users doctors caregivers patients etc considered medical device mds thus subject pass risk based regulatory process evaluates system safety put market thus human centred risk analysis paramount importance establish safety level ami paper propose dynamic probabilistic risk assessment approach ami allows quantitative assessment risk different hazard scenarios order support design development ami provide objective evidences needed regulatory process addition support risk based methodology define probabilistic risk model based extension markov decision process capable taking account two main ami context awareness preliminary results show feasibility approach capability model assess risk context aware hazard scenarios
background administration limited due side effects prevention difficult mesenchymal stem cell msc derived implicated novel therapeutic approach tissue injury study demonstrated pretreatment human umbilical cord msc derived prevent development induced renal toxicity activation autophagy vitro vivo methods vitro rat renal tubular epithelial cells pre incubated human lung fibroblast cells control min inhibitor rapamycin inducer treatment respectively cells harvested apoptosis assay enzyme linked immunosorbent assay elisa western blot quantitative real time polymerase chain reaction qrt pcr vivo constructed induced acute kidney injury rat models prior treatment injected kidneys via renal capsule rapamycin injected kidney capsule animals sacrificed days injection renal function assay tubular apoptosis proliferation autophagy response evaluated results inhibited induced mitochondrial apoptosis secretion inflammatory cytokines renal tubular epithelial cells vitro increased expression marker protein autophagy related genes cells rapamycin effects protecting induced renal injury effects abrogated autophagy inhibitor animals conclusions findings indicate activation autophagy induced effectively relieve therefore pre treatment new method improve therapeutic effect
study microstructure texture deformation metallic materials necessitates detailed information physical evidence plastic deformation mechanism involves direct relationship mechanical properties behaviours working conditions generally mechanical properties materials essentially function structure compositions study texture deformation mechanical parts efficient way manufacturing engineering considerable practical interest present paper entails study deformation mechanism microscopic scale situ observation microstructure texture deformation using ray computed tomography medical scanner installed paris industrial materials laboratory evaluating plastic deformation mechanism inner health analysis presented slices examined parts laboratory scale received heat treated specimens elsevier rights reserved
cellular adaptive immune response plays key role resolving influenza infection experiments individuals successively infected different strains within short provide insight underlying viral dynamics role cross reactive immune response resolving acute infection construct mathematical model within host influenza viral dynamics including three possible factors determine strength cross reactive cellular adaptive immune response initial naive cell number interaction cells epitopes presented infected cells epitope abundance per infected cell model explains experimentally observed shortening second infection cross reactivity present shows memory cellular adaptive immune response necessary protect second infection
purpose review past years important changes development liver transplantation around world particular several emerging countries rapidly developed transplant programs also important changes liver allocation utilization donors cardiac death living donors review practices different countries around world help provide reader better appreciation program recognition potential areas improvement based experience colleagues recent findings recent series articles published journal liver transplantation summarizing practice liver transplantation representative countries around world summary volume liver transplant varies widely country important growth volume emerging countries liver transplant candidates prioritized surgery model liver disease score exception germany usa patients transplanted model liver disease score hepatitis common indication liver transplant notable exception several european countries innovative strategies donation developed several countries
background inflammation heart muscle follow various viral infections children rarely develop life threatening acute viral given causal viral infections common unknown genetic lesions underlie mouse genetic studies demonstrated interferon ifn alpha beta immunity defects increased susceptibility virus induced moreover variations human potent inducer proposed underlie objectives study sought evaluate hypothesis human genetic factors underlie previously healthy children methods tested role ifn immunity using human induced pluripotent stem cell derived cardiomyocytes performed whole exome sequencing unrelated children acute proven viral causes results found deficient cardiomyocytes susceptible virus infection control cells moreover induce ifn alpha beta ifn alpha beta stimulated genes control cardiomyocytes finally exogenous ifn alpha substantially protect cardiomyocytes observe significant enrichment rare variations ifn alpha beta related genes surprisingly found homozygous heterozygous rare variants genes associated inherited significantly enriched patients compared healthy individuals patients diseases seven patients carried rare homozygous compound heterozygous splice site variations cardiomyopathy associated genes dsp conclusions previously silent recessive defects predispose acute heart failure presenting notably common viral infections children american college cardiology foundation
background besides genetic factors known trace elements selenium copper zinc essential thyroid gland thyroid hormone metabolism moreover metals effect suggested patterns associated overt thyroid disease aim study thyroiditis chronic thyroid gland common disease thought explore potential effects essential toxic metals thyroid function ability restore euthyroid status results cross sectional case control study investigated status essential elements selenium copper zinc toxic metals blood female patients thyroiditis overt hypothyroidism compared female healthy persons tried establish presence correlation previous mentioned elements thyroid function hypothyroid patients healthy participants conclusions results study suggested blood concentration essential trace elements especially ratio copper selenium influence directly thyroid function patients overt hypothyroidism thus findings implication life long substitution therapy terms thyroxine dose reduction furthermore first time study shown potential toxic effect cadmium thyroid function patients dose thyroxine substitution
objective determine opinion nursing faculty researcher effectiveness non verbal communication classroom methods descriptive study included nursing minutes fourteen aspects non verbal communication evaluated opinions effectiveness non verbal communication expressed simple frequencies results identified coherent good effective adequate facial expressions efficient positive reinforcing following speech voice rhythms effective good adequate speed physical energy levels good rhythm active effective adequate alert body kept moving standing remaining using hand movements illustrate points attention focused students position close students less frequent inefficient non verbal communication seen among conclusion nursing opinions non verbal communication classroom general non specific indicating inadequate application non verbal communication identified inefficient non verbal communication behavior less often one current researchers
background interest natural antioxidants especially growing thanks positive contribution human health thus prevention harmful action oxidative stress involved many diseases cancer inflammation diabetes cardiovascular illness recent research proved bioactive compounds richness date seeds good biological matrix natural antioxidants unfortunately important quantity dates seed yearly methods study different solvents extraction water methanol absolute aqueous used evaluation effect level vitro antioxidant activities vitro hyperglycemia key enzymes inhibition vivo anti inflammatory established date seeds results result revealed polar solvent exhibited highest amount bioactive compounds correlation polyphenol compounds antioxidant explains powerful effect used polar solvents inflammation hyperglycemia inhibition furthermore showed higher capacity radicals conclusions therefore big waste seeds used cheap source natural antioxidant compounds considered health challenge poor countries
study concentrates finding truncated impossible substitution permutation networks instead using miss middle approach authors propose mathematical description truncated impossible first prove truncated impossible rounds cipher obtained searching entry differential pattern matrix layer thus length impossible cipher upper bounded minimum integer entry second provide two efficient algorithms compute bit matrices using tools prove longest truncated impossible structure round layer designed maximum distance mds matrix finally truncated impossible advanced encryption standard aes aes mds present obtained
vast majority practical engineering design problems require simultaneous handling several criteria simplicity priori preference one turn many design tasks single objective problems handled using conventional numerical optimization routines however situations acquiring comprehensive knowledge system hand particular possible trade offs conflicting objectives necessary calls multi objective optimization aims identifying set alternative pareto optimal designs popular solution approaches include population based unfortunately methods practical problems involving expensive computational models particularly case microwave antenna engineering design reliability requires utilization cpu intensive electromagnetic analysis work discuss methodologies multi objective design optimization expensive simulation models solution approaches present rely surrogate based optimization paradigm design speedup obtained shifting optimization burden cheap replacement model surrogate latter utilized generating initial approximation pareto front representation front refinement high fidelity simulation model level demonstrate several application case studies including wideband matching transformer dielectric resonator antenna ultra wideband antenna dimensionality design spaces considered examples vary six fifteen design optimization cost one hundred high fidelity simulations respective structure extremely low given problem complexity elsevier rights reserved
ocular surface changes abnormalities established parkinsons disease rate influenced corneal sub basal nerve density however relationship yet investigated parkinsons disease case control study examined ocular surface patients moderately severe parkinsons disease including confocal microscopy fifteen patients moderately severe parkinsons disease modified grade fifteen control participants recruited assessment included lamp examination rate assessment central corneal vivo corneal confocal microscopy effect disease also investigated patients parkinsons disease ten male mean age years corneal sub basal nerve density markedly reduced patients parkinsons disease compared controls corneal sensitivity differ significantly patients parkinsons disease control group sub basal nerve density significantly different eye side body severe motor symptoms contralateral eye significant positive correlation ace scores sub basal corneal nerve density first study report significant reduction corneal sub basal nerve density parkinsons disease demonstrate association cognitive dysfunction results provide evidence support involvement peripheral nervous system parkinsons disease previously thought central nervous system disorder elsevier ltd rights reserved
work presents fully differential operational amplifier opamp design architecture achieves high gain bandwidth low power consumption verification architecture implemented low cost bulk cmos technology chip achieves high gain bandwidth ghz degrees phase margin low power consumption course even better results possible sophisticated technologies like massively scaled technologies available opamp used analog filters communication systems enables real time ability
environmental dna comprises dna fragments environment organisms extracted environmental samples water soil characterization allow researchers infer presence absence species particular site without need locate identify individuals therefore provide extremely valuable tool quantifying biodiversity however often case relatively new protocols methodological challenges remain number earlier reviews discussed challenges none provided extensive treatment critical decisions surrounding molecular markers primer development use assays review discusses number options approaches used determining primers gene regions appropriate either targeted species detection macro organisms latter represents new field growing rapidly potential future assessments community ecosystem diversity
understanding landscape structure shapes genetic structure populations species important long term management tested unidirectional dispersal hypothesis linear river landscape river one catchment one gene pool hypothesis red populations complex therefore conducted release experiments field sampled adult trees plant material genetic analyses allowed estimating genetic diversity structure dispersal genetic diversity populations downstream differ significantly upstream populations molecular variance populations correlate position linear landscape contemporary historical migration estimates indicated bidirectional dispersal downstream upstream direction along river confirmed dispersal directions derived field experiments bayesian clustering analysis assigned individuals one cluster suggesting high inter catchment connectivity river flow currents wind operate together ensure high genetic connectivity within complex
acute antidepressant effects patients bipolar disorder however little information regarding appropriate serum levels time remission start therapy patients bipolar depression naturalistic prospective pilot study twelve patients depressive symptoms evaluated using depression rating scale start treatment time remission blood samples obtained time remission distance used analyze relationship improvement rate serum level furthermore calculated spearmans rank correlation coefficient relationship improvement rate serum level produced box plots serum level remission time remission distance patient administered acid differed significantly patients linear relationship serum level improvement rate among patients receive acid median time start therapy remission weeks serum level important impact acute therapeutic effects bipolar depression addition consider different treatment options considered non responders exhibit improvement administration approximately weeks
paper presents new model describes physical phenomena occurring individual outer hair cell human hearing organ new model employs concept parametric amplification consequence proposed model explain natural way many yet unresolved problems mechanisms power amplification nonlinearity fine tuning high sensitivity take place human hearing organ mathematical analysis model performed equivalent electrical circuits individual established high selectivity parametric amplifier analyzed solving resulting differential equations analytical formula power gain parametric amplifier developed proposed model direct physical interpretation elements physical counterparts actual structure numerical values individual elements electrical equivalent circuits consistent experimental physiological data anticipated proposed new model contribute future improvements human implants development new digital audio standards
present study explored presence meaning life search meaning life correlation health anxiety meaning life questionnaire short health anxiety inventory completed individuals results indicated higher presence meaning life associated lower health anxiety opposite observed search meaning life results also revealed interaction presence meaning life search meaning life individuals high search meaning life high presence meaning life lower health anxiety high search meaning life low presence meaning life findings suggest presence meaning life search meaning life correlates health anxiety
assumed resistance radiation cross resistance abiotic stresses side effect evolutionary based adaptation animals dehydration stress larvae prolonged high doses radiation exposure understanding mechanisms cross tolerance types stress exposure genome wide mrna expression patterns using microarray techniques larvae collected different stages exposure two types radiation high linear energy transfer let ions dose low let radiation gamma rays expression profiles wide transcriptional response stress much exceeded amount regulated transcripts irradiation exposure observed extensive group regulated overlapped transcripts response radiation found among overlapped set transcripts indicated related genes antioxidants late abundant proteins heat shock proteins overexpressed group protein aspartate methyltransferase probes corresponding proteins represented performed functional analysis showed strongly enriched gene ontology terms associated protein methylation addition active processes dna repair detected assume cross tolerance sleeping irradiation exposure comes complex mechanism adaptation
system strains external loads certain amount time influence environmental factors define rheological behavior rheological phenomena depend many factors temperature air humidity moisture content rheological system term intensity duration type geometry parts loadings terms intensity variation duration defects aggressive environment composition material properties combinations factors science based theories strength materials thermodynamics chemistry materials science terms application provides personalized analysis diagnosis according condition structures systems used constructions subjected various loadings short long durations joints elastic flexible failure occurs gradually plastic failure occurs sudden failure joints caused shear predominant load wood resist shear stresses order study rheological behavior wood joints metal constant load three types joints terms diameters systems tested stressed traction force days real conditions temperature degrees degrees humidity aim tests determine rheological behavior joints variation deformations relation relative humidity temperature rate strain connections determining rheological model wood found low temperatures winter degrees correlated high relative humidity led sudden changes strain observed high speed deformation joint largest diameter rod paper highlights rheological analysis joints real conditions temperature humidity regards applied tension determination creep function characterizes types connections establishing optimum diameter published elsevier ltd
system symbolic formal language objects implemented python work extend capabilities implementing methods manipulate transducers one level higher existing formal language systems implement methods manipulate objects representing classes independent languages widely known code properties methods allow users define code properties combine fixed properties codes codes error detecting codes etc satisfaction decision questions properties new online system laser allows one query code property obtain answer batch mode work founded independence theory theory rational relations transducers contributes improved algorithms objects
information leakage memory significant threats security modern operating systems attacker able obtain binary code program possible reverse engineer source code uncover vulnerabilities exploits subsequently patch together code segments form code reuse attacks activities particularly concerning program device driver operating system kernel since facilitate escalation ability persist execute code way inhibit memory current bit virtual memory implementation provide capability enforce execute access authors present implementation novel line lightweight layer employing commodity virtualization features dynamically inserted running kernel prevent memory code execute unlike alternative approaches operate user level applications utilizes self protection techniques guarantee integrity even event attacker able gain root level access technology combined fine grained load time diversity mitigate additional threat indirect memory concepts integrated within experimental like bit concepts general applied operating systems implementation subtle requires detailed understanding kernels interaction virtual memory layer consideration time load kernel code kernel data distinct pages memory early evaluations quantify code size complexity run time performance cost effectiveness information leakage provides complete like execute protection kernel code runtime performance overhead due advanced modern techniques architecture overall paper contributes presentation implementation evaluation lightweight tool execute access control kernel code using virtualization features modern architecture
background cervical cancer common malignant tumor great impact womens health human papillomavirus hpv implicated cervical cancer lesions two possibly two stages disease progression technological development molecular biology epidemiology detection treatment hpv become important means prevent cervical cancer methods present novel rapid sensitive specific isothermal method polymerase amplification established detect two common high risk human papillomavirus type type dna study evaluate efficacy assay clinical specimens using plasmids standard operates constant low temperature without thermal instrumentation incubation products detected via gel electrophoresis assay reverse dot blot assay quantitative real time assay green assess diagnostic performance assay detecting clinical samples patients suspected cervical cancer results results revealed cross reaction hpv genotypes assay achieve sensitivity copies compared taqman qpcr technique achieves exponential amplification need pretreatment sample dna degrees minutes reveals satisfactory performance agreement qpcr assays kappa positivity kappa positivity indicating good correlation tests conclusions importantly assay demonstrated useful powerful method detection hpv virus therefore serve valuable tool rapid diagnosis hpv infection commercial clinical applications
background mental health treatment gap youth low middle income countries substantial strategies urgently needed mitigate serious health social consequences untreated mental illness youth aims estimate burden major depressive episode posttraumatic stress disorder ptsd utilization care among youth order describe mental health treatment gap setting methods estimated point prevalence ptsd subthreshold variants school based sample youth ages using modified structured clinical interview dsm axis disorders scid based interview examined treatment utilization among receiving one diagnoses assessed additional psychopathology self report measures examine validity study diagnostic assignments results combined prevalence full syndrome subthreshold ptsd high large majority affected individuals accessed mental health services health sector accessed care kind either health sectors past year conclusion findings demonstrate high mental health burden among youth many youth ptsd accessing mental health care
represents growing threat natural communities across globe small aquatic habitats ponds especially vulnerable often poorly protected legislation many ponds threatened development pollution surrounding landscape yet biodiversity conservation value remain poorly described report results survey ponds along urban land use gradient west outline environmental conditions urban ponds identify local landscape scale environmental variables determine biodiversity conservation value ponds cluster analysis identified four groups ponds contrasting reflecting differences cover nutrient status nature pond edge surrounding land use availability wetland habitats pond conservation status varied markedly across sites high conservation value found ponds complex stands floating vegetation low nutrient concentrations little surrounding urban land found highly urban ponds hard engineered edges heavy nutrient rich waters random forest classification model revealed local factors usually landscape scale factors determining pond conservation value constitute priority focus management
background literature shown good results partial large massive tears role factors affect less clear purpose study twofold examine clinical outcomes following complete partial repair large massive full thickness tear explore value clinical surgical factors predicting methods secondary data analysis consecutive patients large massive tear required surgical treatment complete partial repair followed two years disability measures included american shoulder surgeons relative constant score cms shortened version western ontario index relationship predictors examined logistic regressions chi square statistics appropriate within group change time group differences disability outcomes range motion strength examined students tests non parametric statistics results one hundred twenty two patients women men mean age included analysis large fully partially fully partially massive tears associated age sex pre operative active flexion fully tear group showed better pre operative score better active external rotation neutral associated tear shape size tendon quality conclusions large massive tears affected number clinical surgical factors patients whose tears fully showed statistically significant improvement range motion strength disability years although slightly inferior results compared complete
accurate predictions fluid properties density oil formation volume factor bubble point pressure reservoir engineering calculations paper approach based nonlinear system identification modeling nonlinear predictive model proposed forecasting pressure volume temperature properties crude oil systems end two datasets one containing samples different iranian oil reservoirs containing data various geographical locations employed construct train evaluate test models simulation results demonstrate proposed models outperform previously employed methods including three types artificial neural networks models committee machine multilayer radial basis function two types models grid partition fuzzy mean several empirical correlations smallest prediction error reliable models predicting oil properties reservoirs engineering among soft computing approaches elsevier rights reserved
worldwide mobile software market grown dramatically since feature phones became popular early practice mobile usability defined resource constrained device two ways namely user experience user interface regarded key gaining superiority terms market share customer unfortunately standards software design development process unified modeling language rational unified process seem promote mobile usability systematic manner practice paper proposes systematic approach modeling evaluating properties mobile usability herein treating first class software quality perspective software engineering devise evaluation framework mobile usability call evaluation framework throughout paper specified inter scene interactions users terminals software products using extended navigation viewpoints model adopted observe whether model meets set given properties importantly analysis design extended support design major roles activities artifacts explicitly monitored controlled stakeholders case studies demonstrate works properly treat software products prioritize mobile usability consequently plays key role filling gap two research disciplines address usability software engineering human computer interactions
usually fish industrial highly variable composition time good performance treatment processes necessary limit variation however extended wastewater monitoring including relevant analytical parameters expensive work proposes efficient approach minimize analytical number without compromising global characterization goal way fish industry variability assessed interpreted multivariate statistical tools application analytical data obtained monitoring program carried fish industry northern portugal physicochemical parameters determined samples collected months period results achieved correlation analysis principal component analysis pca cluster analysis led main water pollution sources identification minimization physical chemical parameters number analyzed order achieve correct wastewater characterization minimum cost main pollution sources proved step waters dissolved organic carbon total suspended solids conductivity one parameters identified important parameters monitored order obtain accurate characterization allowing define appropriate wastewater treatment institution chemical engineers published elsevier rights reserved
paper concentrates validation metaheuristic algorithms like search optimization algorithm fruit fly optimization algorithm tuning optimal pid controller automatic generation control purpose two area interconnected thermal system nonlinearities like generator rate constant time delay considered proposed work implemented using matlab simulink various load conditions objective functions metaheuristic algorithms capturing signals various positions proposed model results obtained using two algorithms compared explored elsevier rights reserved
paper present evolution computer programming course teaching methodology evolved linear non standardized methodology flexible non centered methodology methodology uses learning platform supports learning process offering students custom navigation content material interactive way book exercises videos open access approximately students university take course term however evolved static evaluations based online process based cat questions ask student student grade according students ability
paper introduces new electronically tunable universal mixed mode filter topology mainly consists single newly introduced modified current conveyor trans conductance amplifier active element two capacitors two resistors passive elements filter topology realize low pass band pass high pass band reject pass filtering responses four different possible modes operation namely current mode voltage mode trans impedance mode trans mode applying appropriate conditions selection inputs outputs operating circuit need inverted type scaled type current voltage input signal filtering response realization also encouraging sustain feature interactive electronic quality factor band width independent pole frequency variation single current active element proposed filter simulated pspice software using standard cmos technology offers low incremental active passive sensitivities
department mechanical materials engineering faculty engineering built environment offers two master programs namely master science industrial technology management master engineering manufacturing systems using executive part time mode practicing engineering managers manufacturing industry aim programs provide higher degree learning opportunity engineering managers advance knowledge manufacturing processes industrial technology management program high demand potential students due rapid technological advancement international business competition products services new competitiveness business environment made crucial engineering managers enhance technical managerial skills performing daily tasks programs first offered academic session paper authors like present analysis customers students academic session respect programs appropriateness main aims presenting paper identify programs strengths weaknesses respect course contents mode delivery done authors like use students update improve course contents mode delivery program par established universities results study show programs still many weaknesses terms course contents mode delivery thus need attention department alleviate shortcomings published elsevier ltd selection peer reviewed responsibility teaching learning congress
purpose small medium sized enterprises form significant portion many vulnerable impact extreme weather events particular importance construction industry overarching majority construction companies account majority employment income generation within industry previous research identified construction worst affected paper aims discuss issues design methodology approach given recent occurrences predictions suggesting increases intensity frequency future improving resilience construction vital achieving resilient construction industry conceptual framework first developed expanded based empirical evidence positioned within pragmatic research philosophy case study research strategy adopted overall research strategy investigation findings based findings two depth case studies construction framework developed represent resilience construction resilience seen collective effect vulnerability coping strategies coping capacities characteristics wider economic climate originality value paper provides original contribution towards overarching agenda resilience policy making area risk management presenting novel conceptual framework depicting resilience medium sized construction companies
background self harm associated increased suicide risk constitutes major challenge adolescent mental healthcare current study examined association different aspects adolescent health risk later self harm requiring hospital admission methods linked baseline information year old participants norwegian young study patient records self harm years follow used cox regression estimate risk factor hazard ratios results eighty nine persons female admitted hospital self harm self poisoning frequent method mental anxiety depression somatic epilepsy migraine health issues associated increased risk self harm related hospital admission conclusions several health issues adolescence markedly increased risk later self harm current findings incorporated reduce self attempted among young people
motivated repeated previous decades investigate whether heavily market crude oil driven theoretical modeling draw convenience yield approach order approximate fundamental value oil price separate oil price fundamental bubble component expressing standard present value oil price model state space form introduce two markov regimes state space representation order distinguish two distinct phases bubble process namely one oil price bubble stable process one bubble estimate entire markov switching state space specification using robust bayesian markov chain monte carlo methodology based techniques designed statistically separating markov regimes bubble process find robust evidence existence recent oil price dynamics elsevier rights reserved
traditional fluid structure interaction techniques based arbitrary lagrangian method strong coupling method used solve fundamental discretized equations discretization resulting nonlinear systems solved using iterative method leading set linear subsystems resulting linear subsystem matrices sparse non symmetric small zero entries small matrices render incomplete factorization unstable inaccurate improve paper proposes approach used together stabilization offers additional feature used gain advantage parallelization published elsevier ltd
present study investigates possibility using blended class fly ash residual rice ash production green building application mixture design algorithm order provide new use solid waste materials study uses rice ash partial fine aggregate substitution studied mixtures solid size prepared forming pressure temperature degrees relative humidity tests assessed compressive strength flexural strength bulk density void volume water absorption test results showed samples demonstrated excellent properties compressive strength flexural strength ranged respectively additionally content values water absorption void volume ranged respectively values requirements codes also demonstrated great potential using blended producing green building
purpose human thyroid development complex still unexplained process thyroid congenital anomaly one thyroid lobes fails develop majority patients thyroid genetic background remains unknown aim study search novel genetic contributors etiology thyroid methods cohort sporadic patients diagnosed thyroid one three generation family subjected comprehensive genomic examination initially targeted screening associated transcription factors known linked thyroid development performed next step genomic examinations applied using high resolution microarrays whereas thyroid family additionally whole exome sequencing performed results screening transcription factors revealed causative mutations studied cohort genomic examinations revealed presence four recurrent defects three deletions one duplication affecting highly conservative proteasome genes thyroid family splice site mutation proteasome gene found affected mother conclusions results new light etiology thyroid far suspected linked mutations genes directly involved thyroid development demonstrated first time genomic alterations proteasome associated genes occur patients presenting developmental anomaly
paper symbolic computation lie symmetry analysis test conservation laws similarity solutions generalized dimensional variable coefficients equation studied firstly derive group classifications corresponding symmetry reductions via lie group method new variable separation solutions lie symmetry properties discussed integrable conditions system determined via analysis last new infinite time dependent conservation laws derived base new conservation theorem proved elsevier inc rights reserved
development deployment renewable energy sources res also low carbon technologies successful way promoting new technologies creating feasible investment case making competitive traditional energy sources although different incentive mechanisms exist feed shown best model accelerating development guaranteeing producers preferential prices produced electricity period time enabling access power network produced electricity due benefits feed models common model stimulating res integration southeast europe paper reviews current state preferential res countries southeast europe countries already significant installed res capacity others still planning stage review shows amount installed capacity specific technology strong impact support future projects technology comprehensive review development supporting res technologies preferred different countries region supported feasibility assessment res using example two different technology projects wind photovoltaic analysing impact current return investment country region
background despite public health campaigns encouraging women take daily acid supplement proportion reproductive age women united states comply recommendation less optimal objective analysis identify predictors acid containing supplement use define subgroups women benefit targeted acid campaigns methods study included mothers live born infants control population national birth defects prevention study logistic regression analyses used identify predictors acid supplementation classification regression tree analysis used define subgroups women different patterns acid supplementation results race ethnicity education age delivery employment income number smoking birth control use significantly associated acid containing supplement use based analysis education race ethnicity age distinguishing factors women different supplementation patterns non white women years college women supplemented acid conclusion results demonstrate need continued efforts increase acid supplementation among reproductive aged women however success efforts improved maternal characteristics education race ethnicity age considered development future interventions wiley periodicals inc
ever increasing accessibility different multimedia contents real time difficult users identify proper resources vast number choices utilizing users context consuming diverse multimedia contents identify different personal preferences settings however need reinforce recommendation process systematic way context adaptive information contributions paper twofold first propose framework called enables collection contextual information delivery resulted recommendation adapting users environment using ambient intelligent ami interfaces second propose recommendation model establishes bridge multimedia resources user joint preferences detected contextual information hence obtain comprehensive view users context provide personalized environment deliver feedback demonstrate feasibility two prototypes applications use contextual information recommendations offline experiment conducted shows improvement delivering personalized recommendations based users context two real world datasets
background milk egg wheat foods typical western diet despite foods impact food allergy health related quality life amongst adolescents incompletely understood aims study make use swedish version disease specific food allergy quality life questionnaire form investigate association objectively diagnosed food allergy amongst adolescents methods cross sectional study adolescents aged years boys objectively diagnosed allergy foods milk egg wheat living sweden included adolescents completed corresponding scale best worst overall domain specific established adolescents also reported symptoms auto prescription presence food allergies history anaphylaxis defined among reporting difficulty breathing inability stand collapse loss consciousness clinically different set mean difference results overall mean poorer average mean domain risk accidental exposure significantly associated clinically better domain allergen avoidance dietary restrictions mean difference girls clinically worse statistically significantly different mean boys mean difference tended worse amongst allergies three foods prescription number types symptoms including history anaphylaxis associated worse conclusions ascertained via food allergy specific questionnaire adolescents food allergy report poorer average specifically relation emerging independence need support girls clinically worse boys number type previous symptoms history anaphylaxis associated worse
psychotic symptoms frequently occur parkinsons disease pathophysiology poorly understood according national institute health programme pathophysiological basis neuropsychiatric symptoms better understood terms dysfunction underlying domains trans diagnostic fashion abnormal striatal reward processing proposed key domain contributing pathogenesis psychotic symptoms schizophrenia theory received empirical support study schizophrenia spectrum disorders preclinical models psychosis tested psychosis associated therefore investigated brain responses associated reward expectation prediction error signaling reinforcement learning associated psychosis instrumental learning task monetary gains losses conducted fmri study patients without history psychotic symptoms along sample healthy controls conducted region interest analyses ventral striatum prefrontal posterior cingulate cortices whole brain analyses reduced activation patients history psychosis compared without posterior cingulate cortex reward anticipation small volume corrected results suggest cortical striatal abnormalities reward processing putative pathophysiological mechanism psychosis schizophrenia also contribute pathogenesis psychotic symptoms finding posterior cingulate dysfunction keeping prior results highlighting cortical dysfunction pathogenesis psychosis
possible formalism high level description complex reaction systems presented formalism intended framework adopting multi scale modelling simulation tools problems reverse design intensive processes design functional materials formalism exemplified several historical cases fields reaction materials engineering elsevier rights reserved
background monitoring wait times defining targets care advocated improve health care delivery related cancer heart diagnostic imaging joint sight restoration data access care digestive diseases although pose greater economic burden cancer heart disease canada present study compared wait times specialist care recent evidence based consensus defined benchmark wait times range digestive diseases methods total wait times primary care referral investigation measured seven digestive disease indications using practice audit program bench marked consensus recommendations results total wait times patients undergoing investigation exceeded targets probable cancer median days eight days versus target two weeks probable inflammatory bowel disease days days versus two weeks documented iron deficiency anemia days days versus two months positive fecal blood test days days versus two months alarm symptoms days days versus two months refractory without alarm symptoms days days two months chronic constipation diarrhea days days versus two months minority patients seen within target times probable cancer probable inflammatory bowel disease iron deficiency anemia positive blood test alarm symptoms refractory without alarm symptoms chronic constipation diarrhea discussion total wait times seven indications exceeded consensus targets patients seen within target wait time multiple interventions including adoption evidence based management guidelines provision economic human resources needed ensure appropriate access digestive health care canada outcomes evaluated point care practice audit methodology used present study
background developed western settings asthma prevalent among second generation compared first generation migrants however studies difficult interpret include migrants various countries origin objective assessed association parental status disorders among children born hong kong developed non western setting many children parents china ethnicity methods used cox regression examine adjusted associations parental status time first public hospital admission asthma international classification diseases ninth version clinical modification days years population representative birth cohort chinese children hong kong results parents migrants associated higher risk hospitalization asthma disorders compared parents hong kong born hazard ratio confidence interval days years adjusted type hospital birth parental history allergies mothers age birth fathers age birth highest parental education conclusions clinical relevance unique non western context hong kong second generation migrants higher risk hospitalization childhood disorders compared native population particularly years age study required clarify underlying mechanisms involved
many years traditional process yellow extraction produced wastewater containing significant quantities acid substance put pharmacological uses effectively recovered study aimed provide efficient adsorption material recycling batch experiments showed adsorption capacity depends initial concentration temperature maximal adsorption capacity onto exchanger reached value determined pore diffusion coefficients respectively recovery efficiency achieved comparison pseudo first order pseudo second order equations model demonstrated best fit kinetics data adsorption adsorption desorption experiments proved offers great adsorption capacity high adsorption rate good repeatability order help accurately mass transfer process numerical simulation post processing variables performed clarify adsorption process
paper explores extent people different origins migrants come together everyday life europe instead looking overall perceptions context dependent mediated political ideological currents discourses broader patterns prejudice focus sustained close contacts suggest meaningful organic relationships since often people background leading parallel lives integrating chose focus moreover seek understand relevance role context development relationships despite expressive public discourses supposed negative impact presence immigrants ethnic minorities social cohesion findings indicate close relationships uncommon diverse european cities highlight context plays important role first years migrants settlement relationships develop less formal social settings also less demanding terms host country cultural skills part migrants thus giving opportunity develop close relationships finally analysis supports positive role diversity level development stresses importance socio spatial characteristics location wider urban net
paper discusses possible approach distributed visualization rendering system infrastructure organization based linux environment usage virtualization technologies particular attention paid encountered due environment setup exploitation processes affect system performance usability applications development tools studied provide rapid onset computing resources exploration
tropical insects diverse many highly host specific much evidence suggests insect diversity function host plant diversity yet diversity lineages exceeds diversity plants although species fruit genus strongly host specific eggs single host plant species flower sex species collected multiple hosts represent examples lineages via changes host use investigate patterns diversification within six geographically widespread species collected least two host plant species host plant parts use test evidence local genetic differentiation associated different hosts different plant species flower sexes examine geographic patterns genetic differentiation across multiple south american collection sites four six fly species find evidence local genetic differences collected different hosts six species show evidence geographic structure consistent differences collected collected wide analyses reveal one instance genetically differentiated collected different host species different sex one closest relatives indicating genetic differences often arise least coincident evolution novel host use
histone inhibitors emerged new class anticancer agents targeting biological process including cell cycle apoptosis investigated explained anticancer effects inhibitor alone combination lymphoma cell lines cell viability measured mtt assay apoptosis reactive oxygen species ros generation bcl protein expression cell cycle progression expression determined flow cytometry effects alone combination akt bcl pathways stress assessed immunoblotting shows anti lymphoma activity used single agent capability induce apoptosis synergistically potentiated lymphoma cell lines drug combination reduced proportion cells phases caused increase sub peak synergistic effect accompanied increased ros activation caspase cleavage modulated bcl proteins family addition exposure induced acetylation level alpha extend modified finally apoptosis effect mediated corresponding effect microtubule stabilization data suggest combination novel combination potential use antitumor agent lymphoma
background inflammatory bowel disease ibd considered result interplay host intestinal microbiota pathogenesis incompletely understood ibd adults shown associated marked changes body fluid metabolomics studies children hence prospective study addressed faecal serum metabolomics newly diagnosed paediatric ibd methods paediatric patients ibd undergoing diagnostic controls also endoscopy signs inflammation provided blood stool samples tertiary care hospital blood inflammatory markers faecal levels determined serum faecal metabolomics determined using ultra high pressure liquid chromatography coupled mass spectrometer results serum faecal metabolite profiles newly diagnosed paediatric ibd patients different healthy controls categorized crohns disease ulcerative colitis patients separate groups serum amino acid metabolism biosynthesis signalling pathways perturbed crohns disease also metabolic pathways perturbed compared controls faecal samples increased level several metabolites contrast low intermediate levels crohns disease clear correlation level inflammation faecal levels profile various biologically important metabolites significantly conclusion characterization inflammatory pattern using metabolomics analysis promising tool better understanding disease pathogenesis paediatric ibd
symbolic computation number key advances mathematics computer science applications typically large potentially highly parallel making good candidates parallel execution variety scales multi core high performance computing systems however much existing work parallel computing based around numeric rather symbolic computations particular symbolic computing presents particular problems terms varying granularity irregular task sizes match conventional approaches also presents problems terms structure algorithms data paper describes new implementation free open source gap computational algebra system places parallelism heart design dealing key scalability cross platform portability problems provide three system layers deal three important classes hardware individual shared memory multi core nodes mid scale distributed clusters multi core nodes full high performance computing systems comprising large scale tightly connected networks multi core nodes requires develop new cross layer programming form new domain specific allow seamlessly target different hardware levels results show using approach achieve good scalability two realistic high performance systems comprising cores ubiquitous multi core systems distributed clusters work reported way towards full scale exploitation symbolic computation high performance computing systems demonstrate potential two major case studies authors computation practice experience published john wiley sons ltd
paper describes development motivating innovative multi robot formation control platform laboratory experiments mobile robots platform composed two components simulator environment experiment low cost mobile robots environment constitutes ready use test tool provides engineering students opportunity simulate test many different formation cooperation control strategies real system currently platform used systems control engineering master program offered national university distance education university spain use platform students hands laboratory sessions contributing development engineers
symmetry obtained lax pair residual symmetry relating truncated expansion derived link residual symmetry symmetry obtained lax pair presented residual symmetry localized lie point symmetry original equation larger system finite transformation residual symmetry equivalent second type darboux transformation furthermore applying standard lie group approach prolonged system new similarity reductions exact interaction solutions solitons periodic waves given difficult found traditional methods elsevier rights reserved
paper contains development verification low noise amplifier stages within framework front end digital satellite radio diversity receiver operating around ghz first low noise high gain developed reach high requirements satellite radio reception therefore single ended cascode architecture chosen simulated noise figure gain second differential stage designed fulfill specification regards backward isolation common mode rejection circuit measured gain backward isolation furthermore two stages combined integrated overall performance verified due good noise performance first stage overall noise figure gain backward isolation whole circuit current consumption finally performance compared state art
paper presents satellite orthogonal frequency division technology satellite radio interface international mobile advanced radio interface designed provide various advanced services satellite environments cost effective deployment satellite advanced system radio interface high degree third generation partnership project long term evolution technology advanced also number different features features needed adapt technology satellite specific environments long round trip delay large cell size slow satellite channel paper summarize key features technology propose satellite specific features included technology way satellite show performance evaluation results technology see feasibility satellite copyright john wiley sons ltd
following discovery structure dna became scientists needed able distinguish different dna sequences southern published details new method detecting dna fragments based upon specific sequence indication importance work technique named subsequent methods based similar principles named using play western northern blot simplicity effectiveness technique led universal acceptance standard method identification dna sequences modern laboratory turn around times assume ever greater importance process seem relatively time consuming cases led replacement rapid techniques long range pcr nevertheless years southern blot remains cornerstone molecular biology
water quality early warning system mainly used detect accidental water pollution events water distribution systems identifying types pollutants necessary detecting presence pollutants provide warning information pollutant characteristics emergency solutions thus real time contaminant classification methodology uses multi classification support vector machine svm proposed study obtain probability contaminants belonging category svm based model selected samples feature mostly low concentration samples support vectors thereby reducing influence concentration contaminants building process pattern library new sample points classified corresponding regions constructing classification boundaries support vector experimental results show multi classification svm based approach less affected concentration contaminants establishing pattern library compared cosine distance classification method moreover proposed approach avoids making single decision classification features unclear initial phase contaminants
study conducted prenatal development testis embryo categorized group days group days group iii days group days group days till birth embryos group genital observed days gestation contained accumulation mesenchymal cells immature differentiating fibroblasts germ cells formation sex evidenced day gestation contained small mesenchymal cells large cells arranged chain like manner sex started days gestation increased increase gestation period day gestation sex attained form reverse question mark cells observed among small cells sex day gestation appeared just epithelium day gestation consisted layers mesenchymal cells fibroblasts small thickness increased increase age days gestation outer thick fibrous inner thin vascular layer separately mesenchymal cells start differentiating endocrine cells cells located interstitial spaces day gestation
become existence locally acquired disease history since recognition early reviewed model approaches unknown syndromes australian management guidelines include requirement diagnostic testing national association testing authorities laboratories using therapeutic goods administration licensed tests result efficient diagnosis despite patients left australia pay many thousands non specialist consultations testing laboratories long term therapy multiple antibiotics resulted serious complications including allergies line sepsis colitis studies shown vectors found australia found australian vectors animals patients illnesses propose name chronic syndrome adopted australian disorder research funding enable development consensus case definition studies epidemiology syndrome laboratory investigations identify aetiology surrogate markers disease prospective randomised treatment studies undertaken using ethical protocols
era treatment managed care three trends gaining prevalence graduate training programs practicing community limiting clinicians utilizing therapeutic techniques needed help client achieve long standing change maintaining therapeutic gains post treatment first trend equation empathy hinders therapeutic truly understanding clients internal experience implicitly message anxiety material less room second trend cognition affect results primary focus secondary thought process affective experience behavior thought trend large part due widespread dissemination cognitive behavioral therapy efficacy research belief individuals forms treatment lack empirical support last problematic trend rigid utilization treatment tends result approach treatment limiting psychotherapy set techniques also salient aspects treatment predict positive outcomes treatment process therapy result therapeutic less likely uncover discover multiple origins ones suffering factors always readily available conscious awareness paper discusses trend therapeutic implications result
artificial neural networks ann known ability solve classification optimization tasks applied many fields communications detection among others paper analog realization iterative threshold decoding binary linear codes presented shown iterative threshold decoding algorithm matches structure continuous high order recurrent neural network performance analog realization evaluated simulation compared corresponding digital motivation work analog decoding improves power speed ratio minimizes area consumption large scale integration chip
background mental skills training refers implementation cognitive performance enhancing strategies promote optimal performance aimed develop surgery specific mental skills curriculum msc obtain initial evidence efficacy methods developed msc consisted proven performance enhancing modules efficacy assessed laparoscopic simulator based practice using validated instruments mental skills workload stress addition skill transfer test porcine model paired test used analyze data results nine surgical completed curriculum compared baseline assessment participants improved significantly laparoscopic performance mental skills completion msc participants completed task porcine model without change perceived stress skill transfer test participants observed using mental skills taught msc conclusions surgery specific simulator based msc developed efficacy improving mental skills surgical performance supported surgical skill transfer test elsevier inc rights reserved
recently specific attention paid short dna rna tool cancer diagnosis therapy present study prepared chitosan ratio characterized several techniques selected capable detecting cells linked chitosan loaded doxorubicin used targeted drug delivery prostate cancer cells cells treated complex binding efficiency estimated flow cytometry binding affinity selected compared initial library loading capacity high released within days cytotoxicity cells determined mtt assay specifically cells whereas show specificity cells negative control showed lethal effect cells results lead based simple applicable technique early diagnosis treatment cancerous cells
objective objective study explore effects reactive oxygen species ros hypoxic environment prostatic stromal cells methods materials detect expression ros tissues benign prostatic hyperplasia flow cytometry hypoxic conditions observe changes cells growth ros quantitative pcr used detect hypoxia inducible factor alpha hif alpha androgen receptors vascular endothelial growth factor vegf interleukin examine changes cells growth ros hif alpha vegf hypoxic conditions results expression ros tissues cells hypoxic condition significantly increased promoted proliferation hif alpha vegf upregulated ros significantly decreased hif alpha vegf downregulated cell proliferation declined conclusions hypoxia stimulates generation ros ros play key role
large systems involves several sources uncertainty related severity levels code corrected importance classes located severity importance identified opportunities code difficult estimate fact due dynamic nature software development values accurately determined practice leading sequences lack robustness addition code fragments contain severe quality issues playing important role system address problem introduced multi objective robust model based software problem tries find best trade three objectives maximize quality improvements severity importance opportunities fixed evaluated approach using open source systems one industrial project demonstrated significantly better state art approaches terms robustness experiments based variety real world scenarios suggested solutions found comparable terms quality suggested existing approaches better prioritization opportunities carry acceptable robustness price
paper concerned problem optimal contraception control nonlinear population model size structure first existence solutions established crucial obtaining optimal control strategy moreover shown population density depends continuously control parameters existence optimal control strategy proved via sequence finally conditions optimal strategy derived means normal systems
treatment strategies acute musculoskeletal injury around pain reduction promotion healing order facilitate return normal function activity heat cold therapy modalities often used facilitate outcome despite prevalent confusion modality heat cold use use recommendations use heat cold therapy based empirical experience limited evidence support efficacy specific modalities literature review provides information practitioners use heat cold therapies based mechanisms action physiological effects medical evidence support clinical use physiological effects cold therapy include reductions pain blood flow edema inflammation muscle metabolic demand limited evidence randomized clinical trials rcts supporting use cold therapy following acute musculoskeletal injury delayed onset muscle physiological effects heat therapy include pain relief increases blood flow metabolism elasticity connective tissues limited overall evidence support use topical heat general however rcts shown heat therapy provides short term reductions pain disability patients acute low back pain provides significantly greater pain relief cold therapy remains ongoing need sufficiently powered high quality rcts effects cold heat therapy recovery acute musculoskeletal injury
objective compare efficacy terms disease control survival advanced laryngeal lesions according treatment strategy primary surgery primary invasion pattern cartilage soft tissue involvement methods records patients carcinoma treated university clinic years retrospectively reviewed results disease specific survival group group respectively overall survival respectively positive resection margins regional neck metastases reduced survival lesions treated non still significantly improved survival versus conclusion surgery remains indispensable part treatment local advanced laryngeal cancer high survival results part concept includes adjuvant lesions primary also acceptable primary regional disease strong prognostic factor spite adjuvant treatment cases positive resection margins elsevier ireland ltd rights reserved
heterosexual individuals attention automatically captured physically attractive members opposite sex although helpful selecting new attention attractive relationship alternatives threaten satisfaction commitment existing romantic relationship current study tested hypothesis although mating prime increase selective attention attractive opposite sex targets relative less attractive targets among single participants effect reduced among people already committed long term romantic partner consistent hypotheses whereas single participants responded mating prime greater attentional adhesion physically attractive opposite sex targets relative less attractive targets participants committed romantic relationship showed effect findings extend previous research suggesting presence relationship maintenance mechanisms operate early stages social cognition
support materials integrated circuits lead frame key structural components formation electrical circuits played role internal external wire connections one commonly used lead frames present copper layer alloy often found deep red color chip welding aiming phenomenon paper collected large color change point long time adopted method scanning electron microscope sem energy dispersal spectroscopy eds analysis classified point basis work conducted laboratory simulation aimed kind caused special shaped clusters morphology result shows solution absorb carbon dioxide produce crystals coating surface crystal shows deep red color point macro process high temperature welding chip
untreated sleep disturbances sleep disorders pose significant adverse daytime consequences place children considerable risk poor health outcomes sleep disturbances occur greater frequency children acute chronic medical conditions compared otherwise healthy peers sleep disturbances medically children associated sleep disorders comorbid acute chronic conditions secondary underlying disease related mechanisms treatment regimens hospitalization clinical management include multidisciplinary approach particular emphasis routine regular sleep assessments prevention daytime consequences promotion healthy sleep habits health outcomes
entity resolution concerns identifying pairs entities refer underlying entity avoid pairwise comparison entities blocking methods used sorted neighborhood established blocking method relational databases applied schema free resource description framework data sources widely prevalent linked data ecosystem paper presents sorted neighborhood workflow applied schema free data workflow modular makes minimal assumptions inputs empirical evaluations proposed algorithm five real world benchmarks demonstrate utility compared two state art blocking
background depression common low income pregnant women treatments need fitted meet needs conducted randomized controlled trial comparing brief interpersonal psychotherapy enhanced treatment usual perinatal depression low income women brief model designed better engage low income women utilizing engagement session providing flexible delivery sessions pragmatic case management methods pregnant women aged weeks gestation recruited urban prenatal clinic women scoring depression scale meeting depressive disorder criteria randomized either brief assessed treatment outcomes acceptability feasibility intervention measured session attendance results depression scores significantly decreased brief brief participants reported significant improvements social support satisfaction compared participants even controlling concurrent depressive symptoms brief participants reported high satisfaction program however many participants participate full session course treatment average sessions attended range limitations small sample size use self report measures lack active psychotherapy control group limits interpretation study results conclusions brief perinatal depression acceptable low income women helpful improving depressive symptoms social support however feasibility treatment limited relatively low session attendance spite efforts maximize treatment engagement additional modifications meet needs low income women discussed
recent evidence suggests involvement infection emergence psychotic affective disorders report describe case young brazilian woman affected recurrent ocular presenting manic episode psychotic features context diagnosis bipolar disorder type observed relationship ocular manifestations clinical course bipolar illness confirmed molecular analyses nested pcr high level specific igg case report first showing presence circulating parasite dna time occurrence psychiatric symptoms thus providing support possible role parasite pathogenesis cases
operational amplifier important portion various analog mixed signal circuits today use mixed mode integrated circuits rises analog circuits particularly operational amplifiers cmos technology difficult design due challenging time consuming tasks like counting various conflicting benchmarks wide variety design factors paper presents use particle swarm optimization pso algorithm optimum plan two stage cmos operational amplifier circuit pso algorithm used accept required functionalities performance specifications considering ideal sizing two stage amp circuit optimization code pso algorithm integrated circuit simulator circuit simulated using models tsmc cmos processes technology complete optimization system test setup run operating system results obtained pso algorithm compared earlier works
people anorexia nervosa display reduced facial expression emotions study investigated expression positive affect response film examining non women recovered acute healthy controls results indicated group exhibited non higher duration intensity group comparable group findings warrant longitudinal studies confirm reduced linked acute ameliorating recovery elsevier ireland ltd rights reserved
critical issues scientific reproducibility raised biomedical research including reliability data analyses within given study case example article examined reproducibility issue pertaining use administrative data systems evaluation child maltreatment prevention making use prevention study conducted decade ago provided unique opportunity place randomization study randomized counties condition found community wide implementation parenting family support intervention produced positive impact county wide rates substantiated cases home documented state information system key consideration whether extent administrative record data examined decade later original studys time period yield comparable results based data acquired time study results indicated despite small changes time data patterns statistical effects reproducible two outcome variables substantiated reproduced analyses reflected higher effect sizes clear pattern reduction function intervention home effect sizes quite comparable original ones reflecting preventive impact overall case study illustrated data reproducibility context population outcome evaluation underscores importance reliable population prevalence measurement essential part comprehensive public health strategy aimed prevention elsevier ltd rights reserved
atmospheric effects influence signal registered remote sensors minimized order provide reliable spectral information aquatic systems application atmospheric correction aims minimize effects avoid remote sensing reflectance accurately provides better information state aquatic system means establishing concentration aquatic compounds precisely aim study evaluate outputs several atmospheric correction methods dark object quick atmospheric correction fast line sight atmospheric analysis atmospheric correction landsat surface reflectance algorithm order investigate suitability estimating total suspended matter concentrations reservoir establish concentrations via corrected operational land scene retrieval model calibrated validated situ data thereby achieved results retrieval model application demonstrated able provide suitable values green red spectral bands consequently lowest retrieval errors mean absolute percentage error respectively retrieved near infrared band still challenge tested algorithms published elsevier ltd rights reserved
yet another effort produce better permanent magnet less rotor winding less brushless electric motor drives paper reports work related multiphase high rotor dual flat top alternative current control brushless reluctance machine drives aim produce high torque density low loss torque less rotor machine full usage machine windings core inverter new derivation principle operation essential rotary linear machine topologies finite element method fem analysis torque density torque already built phase poles lab prototype made available show promising results experimental flux decay test results presented together torque measurements validate finite element model advanced iron loss computation finite element analysis indicates moderate core loss although high air gap magnetic flux density current harmonics occur natural behavior machine electrical mechanical parameter identification followed development circuit model based fem imported data parameters four control strategy proposal running experiments generating speed reversal field modes using platform drives three three phase inverters power star connected six phase multiphase reluctance machine presented thus showing operation reduced number switches inverter
background although living united states disproportionately affected hiv development implementation evaluation hiv prevention testing linkage care interventions lag behind efforts occurring communities address sociocultural barriers testing developed multilevel intervention study pilot evaluation individual level component intervention video modules address specific barriers hiv testing common among foreign born latino men methods conducted survey assessing hiv risk barriers testing convenience sample foreign born latino men tested hiv within past year intention test next months measured viewing intervention module selected based survey responses results fifty two participants never tested hiv participants previously tested hiv mean time since last test years participants intention test hiv significantly increased watching module increased intention test associated socio demographic characteristics age country origin reported sexual behaviors number sex partners past year discussion results suggest culturally sensitive individually tailored intervention additional tool encourage hiv testing among previously foreign born latino men one demographic groups highest risk delayed hiv diagnosis united states
introduction diabetic men erectile dysfunction widely studied low testosterone levels causing low sex drive erectile dysfunction aim assess erectile dysfunction sex drive relation testosterone serum levels type diabetes mellitus patients materials methods total patients type enrolled cross sectional study according treatment types divided three groups group patients treated group patients treated group healthy normal non diabetic men taken control total testosterone free testosterone free index sex hormone binding globulin lipid profile anthropometric parameters treated patients compared normal healthy men along sexual health inventory men results total testosterone serum levels high treated patients compared treated patients similarly levels significantly higher treated patients compared treated patients also significantly higher treated patients compared treated patients significantly low compared control also significantly higher treated patients compared treated patients hand testosterone low treated patients nmol compared control low treated patients significantly differed control treated patients intergroup differences significant conclusion leads significant reduction testosterone levels sex drive induction low testosterone induced erectile dysfunction whereas leads significant elevation testosterone levels sex drive erectile function
background exercise training positively influences exercise tolerance functional capacity patients idiopathic pulmonary arterial hypertension however underlying mechanisms unclear hypothesized exercise modulates activated inflammatory state found patients methods single exercise testing performed patients healthy subjects phenotypic characterization peripheral blood mononuclear cells circulating cytokines assessed directly exercise results exercise testing patients showed elevated lymphocytes regulatory lymphocytes tnf alpha whilst lymphocytes reduced patients healthy subject exercise caused immediate relative decrease lymphocytes sustained reduction beta higher decrease higher peak oxygen consumption patients conclusions exercise seems safe immune inflammatory point view patients results demonstrate exercise inflammatory state seems elicit effect patients
low energy used gained lot traction last years technology continuously improving now possible consumers highly durable reasonable price main use context aware software applications requiring localization benefit technology however reliability accuracy location information rather crucial used ambient intelligence healthcare domain systems currently rely received signal strength indication highly reliable highly susceptible diffraction propagation angle arrival lack line sight absorption human body paper propose investigate use two features addition mean new algorithm presented paper improve localization accuracy simple proximity localization
background patients cell disease experience many complications central nervous system cns including stroke silent cerebral neuropsychological deficits cranial rare potentially serious complication procedure case series cranial children three different institutions considered along literature review cranial population results seven children cranial identified three different institutions patients male age presentation ranged years two patients presented headache rest neurologic symptoms presentation four patients required urgent intervention one patient died literature review identified additional cases cranial children treatment ranged supportive care intervention twelve patients completely recovered one patient long term cognitive impairment four patients died combined data cranial mortality rate conclusions although rare cranial fatal considered patients acute neurological symptoms
aimed develop validate fracture health search score prediction risk osteoporotic fractures primary care italy selected cohort patients aged years followed occurrence osteoporotic fracture death end data registration end data availability december age sex history osteoporotic fractures secondary osteoporosis long term use corticosteroids rheumatoid arthritis body mass index smoking alcohol abuse alcohol related diseases interaction terms sex use corticosteroids age secondary osteoporosis entered competing risk regression fine gray method predict risk hip femur overall major osteoporotic fractures coefficients combined obtain individual patients explained variance discrimination calibration measures computed evaluate models accuracy final model tested using independent data source explained variation occurrence hip femur overall major osteoporotic fractures respectively area curve respectively predicted observed ratios revealed margin error lower population sex prediction models hip femur fractures confirmed acceptable accuracy sexes poor explained variance observed overall major fractures findings indicate implemented primary care risk prediction hip femur fractures general practitioners therefore supported tool clinical decision making
planning methodology introduced ensure workers construction sites remain safe distance methodology based assumption hazardous conditions occur sites due proximity different workers depend interaction reinforcing characteristics workers methodology includes matrix based method definition minimum safe distances workers use time space diagrams represent analyze dynamic movements workers site methodology implemented real case study order verify feasibility elsevier rights reserved
due increasing incidence allergies potentially life threatening reactions important working understanding modern diagnostic treatment standards allergic disease molecular diagnosis recombinant single allergens components improves diagnostics insect allergies particularly patients double positive extract based test results detection specific enables double better distinguished cross reactivity based patient history test results patient initially advised avoidance strategies prescribed emergency medication kit indication allergen specific immunotherapy evaluated dose increase phase performed using conventional cluster ultra schedules whereby rapid desensitization performed clinic seems particularly effective initial treatment
building information modelling bim received increased attention construction sector bim becoming widespread common approach design construction maintenance building facilities bim also one widely discussed topics academics professionals construction industry world purpose article present initial results studies use bim construction projects poland czech republic studies cover widely understood field management construction projects research concerns scale use bim construction project management awareness bim possibilities potential participants construction projects paper authors discuss results studies compare situation poland czech republic authors published elsevier ltd
investigation paper generalized variable coefficient fifth order equation describes interaction water wave floating ice cover gravity capillary waves via hirota method bell polynomial approach symbolic computation bilinear forms soliton solutions backlund transformation lax pair derived many conservation laws obtained based bell polynomial backlund transformation soliton fusion influence variable coefficients equation analyzed variable coefficients direct proportion soliton velocities effect amplitudes another constant coefficient affect types interactions sense elastic elastic interactions among three solitons presented elsevier inc rights reserved
background pregnancy associated osteoporosis lead serious difficulties fragility fractures back pain height loss affected women soluble receptor activator nuclear factor kappa ligand ratio chosen bone metabolism equation many bone diseases characterized bone resorption post menopausal osteoporosis modified acid supplementation study done compare effects high dose day low dose day acid rankl ratio tumor necrosis tnf alpha concentration pregnancy methods forty five pregnant women visited hospital iran september november assigned two groups randomized double blind clinical trial included women took day took day group acid supplementation pregnancy pregnancy biochemical variables serum pregnant women measured end study study registered iranian registry clinical trials results levels significantly higher compared baseline value although ratio reduced significantly high dose acid supplementation significant positive correlation observed decreased rankl levels end study high dose group conclusion high dose acid supplementation decrease bone biomarkers prevent pregnant women increasing decreasing
high quality compounds successfully prepared method combining solid solution sintering process paper prepared compounds exhibit reversible hydrogen desorption process strongly subject content depending instance compound hydrogen form moreover based structural analysis maximum solid solubility determined first time solid solubility thus leads significant decrease delta value mol mol result provides efficient route hydrogen desorption based materials elsevier rights reserved
alcohol related aggression complex problematic phenomenon profound public health consequences examined neural correlates potentially moderating relationship human aggressive behavior chronic alcohol use thirteen subjects meeting dsm criteria past alcohol dependence remission matched healthy controls participated fmri study adapted laboratory model human aggressive behavior point aggression paradigm blood oxygen level dependent activation measured defined aggressive behavior periods monetary reinforced behavior whole brain random effects analyses found group differences brain regions relevant chronic alcohol use aggressive behavior emotional behavioral control subjects responded aggressive response monetary response options significantly higher rates whole brain random effects analyses revealed significant group differences response monetary subjects showing greater activation frontal prefrontal cortex thalamus hippocampus data across subjects regression analyses brain activation aggressive response rate revealed significant positive regression slopes gyrus parietal cortex significant negative regression slopes orbitofrontal cortex prefrontal cortex thalamus middle temporal gyrus analyses response aggressive behavior associated activation brain regions inhibitory emotional control sensorimotor integration goal directed motor activity
search novel drugs enhance myelin repair entities multiple sclerosis top priority neurological research least hinder neurodegeneration neuro inflammatory conditions recently several new compounds potential boost identified using high throughput vitro screening methods however assessing potential enhance vivo using plastic embedded semi thin sections electron microscopy even though gold standard assessing toxic extremely time consuming expensive methodswe screened available myelin dyes staining candidate offers faster easier alternative visualize sections identified black candidate excellent myelin resolution show adapted black staining demonstrate myelin repair rodent spinal cord reliable sections much faster easier less toxic less expensive besides resolve small corpus staining yet readily combined challenging sections validated method human spinal cord tissue experimental demyelination rat spinal cord time course experiment proof principle demonstrate black able reliably detect enhancing properties adapted black staining used rapidly non screen therapies demyelinating diseases
reverse transcriptase domain amplified genomic dna aquatic grass wild relative rice total different sequences obtained according alignment phylogenetic analysis classified seven distinct families five containing multiple sequences two containing single sequence nucleotide sequence similarity values varied widely among sequences indicative high degree heterogeneity sequences intact whereas others stop codon southern blot analysis revealed differential occurrence among representative species grass family upon three groups divided interesting observation whereas occurrence patterns groups among grass species compatible phylogeny group iii shows apparent methylation proposed major mechanism controlling behavior amplification hence distribution mobile elements extent pattern epigenetic modification analyzed southern blotting pair differential sensitivity methylation revealed atypical methylation pattern found two seven families families showed typical methylation patterns found plants heavily methylated rest five families showed atypical pattern methylated verified using mixture probe addition elements exist cultivated rice common wild rice largely highly conserved though showed evidence methylation alteration several rice lines thus atypical patterns methylation played role differentiation distinct groups differential occurrence species grass family elsevier rights reserved
introduce class general sparse matrices based von decomposition doubly stochastic matrices aimed primarily solving challenging linear systems highly unstructured coefficient matrices present theoretical results numerical experiments linear systems variety applications
accuracy robustness proposed fft model root mean square errors fft blind predictions benchmark set complexes bind core set complexes core set complexes mol respectively corresponding pearson correlation coefficients respectively present feature functional theory binding predictor fft protein ligand binding affinity prediction underpinning assumptions fft follows exists microscopic feature vector uniquely characterize distinguish one protein ligand complex another feature function relationship macroscopic features including binding free energy complex functional microscopic feature vectors similarity molecules similar microscopic features similar macroscopic features binding affinity physical models implicit solvent models quantum theory utilized extract microscopic features machine learning algorithms employed rank similarity among protein ligand complexes large variety numerical tests
background bath plus ultraviolet light therapy effective safe inexpensive treatment psoriasis psoriasis due unbalanced ratio cells regulatory cells treg treg functional ratio significantly lower patients psoriasis compared controls inversely correlated psoriasis area severity index score previously reported bath therapy significantly increases number treg treg function almost normal patients psoriasis objectives examined effects bath therapy three distinct subsets activated treg resting treg cytokine non suppressive cells methods enrolled patients psoriasis healthy controls examined cytokine non suppressive cells peripheral blood obtained psoriasis patients every fifth bath therapy session results levels considered strongest suppressive activity patients psoriasis significantly increased early bath therapy sessions diminished levels lower psoriasis patients healthy controls increased bath therapy conclusions bath therapy induced concomitantly improvement psoriatic lesions suggesting mechanism effectiveness bath therapy psoriasis patients japanese society dermatology published elsevier ireland ltd rights reserved
first paper present digital method conventional system apply novel technique nonlinear system identification first observer kalman filter identification method used obtain lower order state space model stochastic chaos system digital approach high gain property applied improve replace observer identified therefore proposed combined observer based digital novel tracker suppresses uncertainties nonlinear perturbations also improves accurate observation parameters complex multi input multi output systems research stochastic chaotic system used illustrative example demonstrate effectiveness excellence proposed methodology
objective aim study evaluate efficacy acceptability second generation vaginal laser treatment vaginal laser therapy management syndrome menopause postmenopausal breast cancer survivors methods study performed using laser crystal aluminum smooth wavelength forty three postmenopausal breast cancer survivors treated three laser applications every days symptoms assessed treatment months using two methods subjective visual analog scale vas objective vaginal health index score procedures performed outpatient basis without anesthesia drug use intervention results baseline values vaginal vas scores third treatment months treatment basal values whereas months last laser application basal values baseline values vas values decreased third treatment months last laser application basal values whereas months last laser application basal values baseline values third treatment months last laser application basal values whereas months last laser application basal values adverse events recorded study conclusions study suggests vaginal laser effective safe treatment syndrome menopause breast cancer survivors
multi view image based rendering consists generating novel view scene set source views general works first coarse reconstruction scene using reconstruction establish source target views followed blending views get final image unfortunately blending weights due scene geometry camera placement result artifacts target view paper show avoid artifacts imposing additional constraints image gradients novel view propose variational framework energy functional derived optimized iteratively solving linear system demonstrate method several structured unstructured multi view datasets show numerically outperforms state art methods eliminates artifacts result visibility
objectiveto perform literature review epidemiology clinical presentation diagnostic evaluation clinical course occipital syndrome including new case report syndrome rare clinical syndrome consisting unilateral occipital headache accompanied palsy headache typically temporal region triggered contralateral head rotation usually associated skull base metastasis often basic neuroimaging studies first manifestation malignancy lead delay diagnosis methodswe performed systematic literature review using pubmed embase along new case report resultsa total cases mean age years range men presented typical unilateral headache followed palsy days headache presentation patients initial neuroimaging studies normal due skull base metastasis cases patients first symptom disease represents warning sign requires exhaustive search underlying neoplasm appropriate clinical evaluation lead earlier diagnosis patients consistent headache
although shares clinical characteristics dementia lewy bodies limited information regarding relationship lewy body pathology report old japanese woman episode confirmed limbic type lewy body disease although exhibited transient visual hallucinations overt dementia developed core clinical features died pneumonia age years case suggests one clinical phenotypes prior onset dementia
study considers intellectual capital based assumption capital possesses social aspects related emotional capacities emotional intelligence organizations members literature review indicates relationship previously noted studied researchers agree emotional intelligence members organization affects organizations intellectual capital based analysis relationship examined turkish business context data collected top managers affect intellectual capital businesses human beings emotional thus study emotional intelligence top managers opinions regarding intellectual capital businesses considered related interesting results factors emotional intelligence likely affect opinions regarding intellectual capital examined using multivariate model effect emotional intelligence revealed primarily three factors emotional intelligence empathy communication skill self awareness affect participants opinions regarding intellectual capital businesses univariate models used evaluate effect emotional intelligence factor participants opinions regarding intellectual capital businesses empathy communication skills affect opinions quality human capital self awareness affects opinions organizational commitment workers affect opinions information technology information sharing summary emotional intelligence affects opinions human capital quality information technology information sharing
consider problem estimating arbitrary dynamical parameter open quantum system input output formalism markov processes show limit large times system output state approximated quantum gaussian state whose mean proportional unknown parameter approximation holds locally size parameter space provides explicit expression asymptotic quantum fisher information terms markov generator furthermore show additive statistics counting measurements also satisfy local asymptotic compute corresponding classical fisher general theory illustrated examples two level system atom results contribute towards better understanding statistical probabilistic properties output process relevance quantum control engineering theory non equilibrium quantum open systems
background contact dermatitis defined inflammatory process affecting skin surface induced contact chemical physical biotic agents environment causes lesions skin means allergic pathogenic mechanisms among main triggers contact dermatitis pediatric age chemical physical agents cause contact dermatitis icd cause tissue damage allergic mechanism allergic contact dermatitis methods prospective multicenter observational study carried children affected contact dermatitis aged years enrolled pediatricians different italian provinces diagnosis contact dermatitis based pediatricians clinical evaluation data collected series simple multiple choice questions filled pediatricians results cases patients complete remission contact dermatitis cases worsening adverse events observed either effectiveness therapy rated effective parents pediatricians patients new therapy prescribed conclusions contact dermatitis heterogeneous inflammatory skin disease induced contact different kinds environmental agents cutaneous manifestations highly variable depend modality contact causative agent pathogenesis italian experience clinical approach contact dermatitis stresses need daily skin care different therapeutic strategies based diagnosis clinical severity parents children compliance first therapeutic measure implemented prevention removal causative agent use protective devices indeed preserving barrier function important goal priority treatment algorithms
computer programming highly cognitive skill requires many domains reality many learners able cope mental demands required learning programming thus leads learning many reasons situation however one main reasons nature novice learners experience high cognitive load learning programming given fact novice learners lack defined schema limitation working memory students knowledge required learning many types learning supports like visualization provide reduce cognitive load expected visualization help reducing cognitive load expanding working memory however effect visualization learning clearly tangible two common methods used measure cognitive load namely physiological non physiological measures found based prior studies non physiological measure appropriate measuring cognitive load class room situation non physiological measures include rating scale also observed prior studies variation learning performance using visualization support among students homogenous group variation attributed level long term memory includes prior mathematical prior language skills demographics gender paper propose framework optimize instruction learners based background profile extent long term memory employ neural network optimize instruction suggesting best visualization tool learner paper also performance proposed tool study learners evaluate accuracy tool
summary retrospective observational study assessed persistence compliance treatment route administration dosing frequency postmenopausal women initiating new osteoporosis therapy two year persistence compliance rates higher women receiving compared oral agents purpose study extends previous studies limited year follow examining persistence osteoporosis therapies year period compares short long term trends persistence compliance among postmenopausal women commercial medicare supplemental insurance usa methods retrospective observational cohort study enrolled women years newly initiating osteoporosis therapy january december index date continuous enrollment months months index date persistence continuous therapy without day gap compliance index therapy evaluated years follow multivariable logistic regression used compare odds persistence compliance across treatment dosing regimens results study included patients mean standard deviation age years years follow persistence compliance higher patients treated agents ranging excluding every month injection treated oral agents ranging additionally patients initiating oral except daily daily acid annually significantly lower odds persistence compared every months conclusions patients initiating therapies greater persistence compliance years initiating oral therapies patients initiating every month injection significantly higher persistence compared initiating frequently daily weekly oral agents
sexual minority stress experiences prejudice victimization etc peer substance use norms peers frequency use quantity consumed important correlates alcohol drug use sexual minority populations current study incorporates examining individuals perceptions peers use alcohol drugs cope sexual minority stressor whether perceptions peer coping norms relate ones coping motivated substance use response stressor three hundred seven sexual minority males females identified gay lesbian bisexual completed online survey approximately month following pulse incident violence people history stressor experienced within communities throughout results revealed peers widely perceived likely alcohol drugs following pulse however small proportions participants reported coping alcohol drugs multivariate models revealed even controlling factors including stress impact pulse odds using alcohol cope event times greater among participants held perception peers likely used alcohol cope relative share perception similarly odds using drugs cope event times greater among participants perceived peers likely use drugs cope pulse compared importantly findings suggest personalized normative feedback designed correct perceptions peers coping motivated substance use utility motivational component larger interventions seeking reduce substance use elsevier ltd rights reserved
non suicidal self injury common multifaceted phenomenon among adolescents recent researchers shown number psychological psychiatric correlates implicated onset repetition previous studies directly observe family interaction patterns clinical population paper quality family interactions observed using play procedure specific interactive dimensions associated adolescents results single case study showed lack positive emotional exchanges parenting style expressing hostility high level control difficulties method authors show better understanding role family interactions crucial improve assessment treatment non suicidal self behaviors research clinical implications discussed
entity resolution important common data cleaning problem detecting data duplicate representations external entities merging single representations relatively recently declarative rules called matching dependencies mds proposed specifying similarity conditions attribute values database records merged work show process benefits integrating four components building classifier duplicate non duplicate record pairs built using machine learning techniques use mds supporting blocking phase record merging basis classifier results use declarative language extended form supported platform activities related data processing specification enforcement mds elsevier inc rights reserved
background highly lethal fungal infection especially immunocompromised individuals methods order review epidemiology diagnosis treatment renal transplant recipients searched publications cases renal transplant recipients pubmed database december results total cases renal transplant recipients included review cases male major underlying diseases diabetes mellitus common site infection species frequent fungus patients pathogen identified species level mortality rates disseminated graft renal higher infection sites overall survival patients received surgical combined amphotericin higher received antifungal therapy alone surgery alone without therapy overall patients receiving lipid higher receiving formulation conclusions severe infection renal transplant recipients surgical combined especially amphotericin significantly improve patients overall survival
research field electronics group semiconductor structures attracted increasing attention past years exceptional combination unique electronic transport properties mature material know highly integrated silicon technology holds promise enhancing state art electronics addition providing conduction channels bring conventional field effect transistors scaling limits physics group new device principles silicon devices beyond complementary metal oxide semiconductor cmos computing virtue distinct switching behavior higher expressive value review reader systematic analysis physics silicon relevant cmos cmos like devices built silicon including inversion mode steep slope quantum reconfigurable transistors
integrated low voltage receiver digital satellite radio presented contains basic building blocks low noise amplifier buffer two phase locked loops provide intermediate frequency local oscillator signals innovative solutions critical blocks buffer voltage controlled oscillator etc new arrangements bias circuits adopted greatly increase circuit performance moreover regulated power supplies power capability also included receiver needs small number external components principally image filter surface acoustic saw channel filter achieves maximum gain noise figure internal regulators set ensure correct operation external power supply varying receiver integrated ghz silicon bipolar technology die size needs quiescent current
research individual differences interpersonal accuracy ability accurately judge others emotions intentions traits social characteristics long tradition represents growing area interest psychology measuring proved correlates skill however despite tradition considerable volume research efforts made look collectively nature tests involved assessing leaving questions broader structure unresolved single skill clustering many discrete skills combination partially overlapping skills multi level meta analysis published participant samples participants analyzed correlations pairs tests different tests altogether overall correlation tests corrected correlations within studies administered two tests reported several correlations participant sample test domain characteristics evaluated explain differences effect sizes general tests similar domains using similar methodologies highly correlated suggesting domains within individual differences cluster implications future research measurement discussed
management athlete syndrome pcs challenging pcs symptoms ongoing symptoms reflect prolonged pathophysiology conditions migraine headaches depression anxiety chronic pain cervical injury visual dysfunction dysfunction combination paper focus physiological signs help narrow differential diagnosis pcs athletes physiological effects exercise especially important athletes athletes pcs exercise intolerance result altered control cerebral blood flow systematic evaluation exercise tolerance combined physical examination neurologic visual cervical systems many cases identify one disorders
background patients smoking status routinely collected general practitioners primary health care abundance read codes pertaining smoking including relating smoking cessation therapy prescription administration codes addition regularly employed smoking status codes large databases primary care data increasingly used epidemiological analysis smoking status important many analyses however variable definition rarely documented literature methods secure information linkage repository national collection person based health socio economic administrative data exploration smoking status data carried explore range codes available used identification different categories smokers smokers never smokers algorithm developed addresses inconsistencies changes smoking status recording across life course compared recorded smoking status recorded health survey individual level however regarded gold standard validation results individuals linked dataset missing data common records algorithm status never smokers detects smokers data distinguishing current smokers non smokers similarity data using nearest date comparison kappa temporal conflicts accounted similarity kappa showing importance addressing conflicts conclusions present algorithm identification patients smoking status using self reported data included sufficient details allow others replicate work thus increasing standards documentation within research area assessment smoking status routine data
paper proposes predictive control algorithm includes conduction mode detection power factor correction pfc converter pfc converters line current usually distorted characteristics proportional integral current controller improve quality current current controller requires additional circuits algorithms however optimal duty cycle determined estimating next state current continuous conduction mode discontinuous conduction mode proposed predictive control method fast dynamic response accuracy compared current control method moreover proposed algorithm detect conduction mode without additional circuitry mode detection algorithm using characteristic optimal duty cycle calculated predictive control advantages proposed algorithm improve quality line current pfc converters verify proposed method performing experiment using pfc converter
aim ecosystem based management maintain ecosystem healthy productive resilient condition implementation policies management measures although cross planning led planning competent authority sector competent authority implement necessary management measures within operations achieve goals objectives suggest scientific longer significant implement instead consider approaching within current policy cycle approaches provide necessary process step addition enabling facilitating collaboration exchange understanding promoted processes also require policy implemented programs measures procedures controls expected outcomes carry effect policy objective view moving planning objective setting operational implementation management problem solving issues instead scientific one
physical performance human elastic tissue assembled make increasingly appreciated protein monomer defined solution shape comprising modular regions elasticity cell attachment collectively participate assembly modular multifaceted molecule exploited enhance physical performance biological presentation engineered constructs augment repair human tissues tissues include skin vasculature emphasize growing knowledge adapted add value pre existing devices like novel multi featured biological implants elsevier rights reserved
interstitial lung diseases heterogeneous group lung disorders distinct clinical radiological morphological features among idiopathic pulmonary fibrosis ipf associated worst prognosis survival worse many cancers even advent two anti fibrotic drugs shown disease progression reaching correct diagnosis crucial pathogenesis prognosis treatment options differ substantially interstitial processes immune overactivity plays role driving fibrosis however subgroup patients fibrotic lung disease mediated immune dysregulation experience progressive fibrosis despite immunosuppressive treatment behave similarly ipf clear even non ipf phenotypes progressive disease exist molecular pathways overlap one main challenges future use high throughput molecular biology techniques patients progressive fibrotic lung disease order identify genetic epigenetic protein markers predict individual patients rate progression fundamental molecular pathways involved review focus challenges diagnosis management idiopathic pulmonary fibrosis differences areas overlap fibrotic including fibrotic hypersensitivity connective tissue disease associated ild interstitial pneumonia autoimmune features
people living hiv aids united states disproportionately high rates food insecurity general population associated cognitive impairment among older adults exacerbate hiv associated neurocognitive disorders current study assessed effects hiv infection neuropsychological performance hiv positive hiv negative adults main effects minimal interactive effects revealed related deficits speed information processing learning memory motor function overall cognitive impairment hiv positive group hiv negative group interactive effects remained controlling relevant sociodemographic characteristics although bidirectional associations ruled cross sectional study results suggest contribute cognitive impairment among hiv positive adults given high rates socioeconomic disadvantage among addressing part routine clinical care warranted
primary myelofibrosis pmf rare chronic bcr negative myeloproliferative neoplasm characterized progressive bone marrow fibrosis inefficient hematopoiesis shortened survival clinical manifestations pmf include splenomegaly consequent hematopoiesis array potentially debilitating constitutional symptoms diagnosis based bone marrow morphology clinical criteria mutations mpl calr exon genes found approximately patients whereas remaining called triple activation jak stat pathway results abnormal leading bone marrow fibrosis mutations accompanied mutations commonly used scoring pmf based international prognostic scoring system subsequently developed dynamic international prognostic scoring system plus employs clinical cytogenetic variables pmf calr mutation associated superior survival inferior outcome patients triple negative pmf higher incidence transformation lower overall survival compared calr mutant patients impact genetic lesions survival independent current prognostic scoring systems observations indicate driver passenger mutations define distinct disease entities within pmf accounting relevant clinical decision making also considered designing clinical trials karger basel
current study aimed address impact serum type diabetes patients angiogenic properties human bone marrow mesenchymal stem cells relationship autophagy signaling human primary stem cells enriched incubated serum diabetic normal subjects days compared data control group diabetic serum found induce higher cellular death rate apoptotic changes also showed diabetic condition significantly abolished angiogenesis tube formation substrate decreased cell response inhibited endothelial differentiation rate western blotting showed status high levels increase ratio vivo plug assay revealed conditioned media prepared cells exposed diabetic serum caused marked reduction recruitment cadherin sma positive cells days subcutaneous injection pcr expression array analysis confirmed overexpression autophagy apoptosis genes cultured cells response diabetic condition using bioinformatic analysis noted crosstalk network angiogenesis autophagy signaling modulate angiogenesis interaction downstream insulin receptor upstream androgen receptor data diabetic serum led abnormal regulation angiogenic response data demonstrate diabetic serum decreased human mesenchymal stem cell angiogenic properties directly angiogenesis pathways induction autophagy signaling cell wiley periodicals inc
background aims high levels serum uric acid associated increased mortality risk general population contrasting results available people diabetes aim study investigate association functional form cause mortality patients type diabetes mellitus methods studied three cohorts patients mortality study mortality study mortality study cause mortality rate end point study results reliable relationship levels cause mortality rate quadratic model approximated higher risk mortality compared hazard ratio confidence interval respectively pseudo sample created real pooled sample best relationship cause mortality rate quadratic tree based recursive partitioning regression tree analysis two subgroups increased risk mortality identified namely levels levels compared patients intermediate levels thus providing evidence shaped relationship levels mortality rate conclusions linearly associated cause mortality rate patients clinical public health purposes association shaped published elsevier ireland ltd
paper proposes new method controlling cross flow water turbine based generation systems fixed pitch power regulation method consists directly controlling electrical generator power imposed without employing inner rotational speed control loop proposed control approach represents base operation framework output power rotational speed limitations start stopping entire operating range cut water flow speed permanent magnet synchronous generator used paper system operated low rotational speed values called hydrodynamic region mechanical hydrodynamic stresses lower given region corresponds unstable dynamic behavior power regulation relies upon inner loop rotational speed stabilization consequently electrical machine current control loop fed reference two components namely driving stabilization currents embodied control laws output power rotational speed limitation sequences experimentally validated real time simulator based generation systems
mechanical manufacturing engineering organizations commonly recognize value knowledge resources yet fail effectively exploit assets knowledge management solutions provide means appropriate exploitation resources published implementations contexts compared wealth solutions published sectors paper demonstrates methodology creation solution space based review analysis characterization sources including examples problems within companies different industry sectors example solution set used identify appropriate tools solve related problems many contexts
association chronic myeloid leukemia cml myeloproliferative neoplasms mpns particular mutation janus kinase gene uncommon cases reported literature present study case year old man cml persistent reported patient achieved complete cytogenetic response major molecular response patient presented mutation bone marrow morphology consistent essential thrombocythemia patient treated hydroxyurea control platelet count maintains complete upon years follow although rare association cluster region rearrangement mutation investigated patients mpn since genetic anomalies present diagnosis emerge treatment require different therapeutic approaches
two dimensional analytical numerical solutions determining geometric dimensions stresses geotextile tubes reviewed conventional one dimensional approximation average drop height consolidated height geotextile tubes also reviewed study modeling fill material based strain analysis introduced als approximation method considers vertical movement material analysis strain method offers alternative analysis approach wherein vertical lateral movements fill material considered geotextile tube assumed resting rigid horizontal foundation analyses filling stages internal material liquid order apply normal pressure tube parametric cases geotextile tube fill presented results show degree tube height reduction decreases density fill increased large scale tests conducted composite geotextile tubes made outer woven inner non woven pet material tubes long theoretical diameters respectively validity solution analysis demonstrated comparing numerical results field test agreement numerical results field measurement data fairly acceptable elsevier ltd rights reserved
background evidence increasingly indicates poor sleep quality major public health concern household food insecurity disproportionately affects novel risk factor poor sleep quality psychological distress potential mechanism affects sleep quality sleep food insecurity distress linked type diabetes mellitus objectives examined relations psychological distress sleep quality tested whether psychological distress mediates relation sleep people diabetes mellitus methods type diabetes mellitus completed baseline assessments community health workers assisting manage stress diabetes stress management intervention trial completed household food security survey measures depressive symptoms personal health questionnaire depression scale anxiety symptoms patient reported outcomes measurement information system short diabetes distress problem areas diabetes questionnaire paid sleep quality pittsburgh sleep quality index psychological distress short paid scales used unadjusted adjusted indirect effect tests bias corrected samples test relations variables potential mediation results mean age women food insecure experiencing associated greater psychological distress worse sleep quality depressive symptoms adjusted anxiety symptoms adjusted diabetes mellitus distress adjusted mediated relation worse sleep quality without adjustment age education income marital status employment status conclusions household food insecurity common potent household stressor associated suboptimal sleep quality psychological distress efforts improve food security decrease psychological distress yield improved sleep high risk population stress management trial registered
migratory phenomenon portugal become one main factors genetic variability last years new class autosomal insertion deletion markers attracted interest forensic genetics since data markers portuguese speaking african countries immigrants living aim characterization groups individuals typing least markers compare different groups individuals populations studied samples belonging immigrant individuals guinea dna extraction performed method extraction samples method obtained results allelic frequencies show markers equilibrium confirm populations show significant genetic distances host population introduce genetic variability population
purpose women around globe predominantly reproductive age women pregnant many want sexually active avoid pregnancy upon release yet women regular method contraception providing contraceptive services women benefits individual public health goals reducing unintended pregnancy policy reviews evidence unmet need family planning setting policy implications expanding services paper aims discuss issues design methodology approach authors describe four model programs usa established contraceptive services site highlighting practical steps facilities implement findings facilities health administrators providers advocates advance policies women family planning make range contraceptive methods available release remaining sensitive potential pressure women feel use birth control unique environment practical implications family planning services women benefits individuals facilities community social implications policies enable facilities provide comprehensive family planning women including reproductive life goals counseling contraceptive method provision promote equity access critical reproductive health services also provide broad scale population level benefits preventing unintended pregnancy enabling counseling healthy pregnancies group women often limited access services originality value policy highlights area health care gets little attention research policy family planning services women addition reviewing importance services population authors also highlight model family planning programs facilities provide insights administrators providers
advances understanding adult stem cell biology facilitated development novel cell based therapies cancer recent developments conventional therapies tumor resection techniques chemotherapy strategies radiation therapy treating metastatic primary tumors brain particularly resulted marked increase patient survival preclinical studies shown multiple stem cell types exhibit inherent migrate sites malignancy recent studies validated feasibility potential using engineered stem cells therapeutic agents target eliminate malignant tumor cells brain review discuss recent progress therapeutic potential stem cells tumors brain also provide perspectives future preclinical studies clinical translation
oxidative stress involved many neurological diseases including alzheimers disease polyphenol derived potent antioxidant study neuroprotective effect glutamate induced oxidative stress evaluated mouse hippocampal cell line treatment protected cells glutamate induced cell death concentration dependent manner potentially attenuated glutamate induced intracellular reactive oxygen species ros restored mitochondrial membrane depolarization metabolic alterations glutamate induced oxidative stress protective effect evaluated hplc profiling methods multivariate statistical analyses alterations ten metabolites identified including amino acids acid threonine cysteine tryptophan lysine fatty acids acid acid acid metabolic pathway analysis revealed involvement multiple affected pathways cysteine methionine metabolism tryptophan metabolism alanine aspartate glutamate fatty acid oxidation results clearly demonstrate promising therapeutic agent oxidative stress associated diseases
many college students exhibit unhealthy eating behaviors consuming large quantities high fat foods fruits vegetables perceived stress linked daily dietary choices among college students however work conducted among predominantly white female populations role perceived stress management moderating relationship unclear study investigated relationship perceived stress dietary choices among diverse sample male female college assessed whether perceived ability manage stress moderated relationship students large public university completed online survey assessed past week consumption various foods fast food fruits vegetables perceived stress ability manage stress hierarchical linear regression examined association perceived stress past week dietary choices moderating effect perceived ability manage stress controlling demographic variables perceived stress positively associated past week coffee energy drink frozen food fast food consumption perceived stress management moderated relationship stress sweet consumption individuals reported low ability manage stress consumed greater amounts findings indicate greater stress associated poor dietary choices among college relationship stress sweet consumption exacerbated among reported low ability manage stress important college nutrition education programs focus relationship stress diet promote effective stress management techniques elsevier ltd rights reserved
objective study determine depression genetics yield quality resistance early tomato consequently twenty inter specific tomato developed crossing five susceptible cultivars four wild resistant tested field conditions early resistance biochemical responses also critically studied parents hybrids showed moderately susceptible reaction except five wild parents exhibited better results susceptible parents hybrids showed moderate reaction early resistance high level phenol found resistant parents hybrids among made manifested resistance capacity low high depression disease yield associated traits expressed high low depression indicated better yield capacity made resistant susceptible ratio indicated dominant additive gene effects remaining showed resistant intermediate susceptible genetic ratio indicated heterozygous nature mediated multiple genes fact utilized future tomato breeding program developing resistant varieties disease published elsevier
many studies date implied biases memory called contribute development maintenance positive symptoms schizophrenia however study exists longitudinally followed patients experiencing positive symptoms present article therefore reviews cross sectional studies retrospective abilities participants within different stages schizophrenia spectrum disorder heterogeneous symptom creating pseudo longitudinal overview summarized deterioration abilities correlating psychosis development inferred reviewed publications indicate biases already found patients state psychosis arms patients first episode psychosis seem severely impaired arms patients similarly affected compared chronic patients contribution biases pathogenesis psychosis discussed giving consideration relations cognitive metacognitive functions neurochemical processes neural correlates hypothesized biases represent early cognitive markers beginning psychotic state early treatment program help patients ameliorate general course illness even prevent risk transition psychosis
purpose mortality salient factor capital purpose paper examine role death plays decisions severely mentally subject possible discrimination capital trial status design methodology approach current experiment measured mental illness beliefs experimentally manipulated type mortality salience dual focused participants mortality exposed trial related death references trial focused exposed death references type severely mentally neutral capital findings mock perceived mental illness important mitigating factor dual self focused mortality salience induced whereas participants exposed trial related death references considered mental illness factor likely evidence stereotype adherence toward practical implications implications authors findings problematic current legal system majority capital exposed trial related death references individuals trial focused mortality condition findings suggest likely engage stereotypes consider fair process making decisions research also suggests mortality salience able increase attention concerns trial scenario even negative mental illness stereotypes present originality value research builds existing management theory offers nuanced perspective focusing ones death affect reliance stereotypes lead inappropriate decisions mortality salience lead decisions based upon procedural fairness stereotypes mortality salience present
murine full thickness skin transplantation established vivo model study response graft rejection despite limited application humans skin transplantation mice widely employed transplantation research procedure easy learn perform require delicate techniques extensive training moreover graft rejection model occurs reproducible immunological reaction easily monitored direct inspection addition secondary skin transplantation donor matched third party skin performed complex transplant models alternative method assess donor specific tolerance complications low general limited anesthesia respiratory distress procedure graft failure hand occurs commonly result poor preparation graft incorrect positioning graft bed inappropriate placement article present protocol full thickness skin transplantation mice describe important steps necessary successful procedure
theme world digestive health day diet gut health world organization thereby raise awareness relationship eat gastrointestinal symptoms world digestive health day year brief review article behalf new zealand society highlight recent developments highly active area research special emphasis gastrointestinal disorders
paper low power consumption regulator proposed ultra high frequency tag stable output voltage sub blocks regulator supplied elementary stage output rectifier proposed operational amplifier circuit works class biased adaptive circuit besides proposed regulator used reference circuit sampling circuit based cmos technology low power consumption output regulator ripple values efficiency regulator respectively considering omega load power consumption regulator calculated operating frequency mhz simulated tsmc cmos technology elsevier gmbh rights reserved
objective implant metal minimally invasive repair procedure often causes metal allergy postoperative infection chitosan anti allergy anti inflammatory effects study conducted evaluate effects chitosan repair patients stainless steel methods total patients recruited randomly assigned two groups one group received repair using stainless steel group another group using stainless steel coated chitosan group infection rate metal allergy index measured presence overt infection evaluated measuring serum levels erythrocyte sedimentation rate esr reactive protein crp results mean month repair postoperative infection occurred cases cases groups respectively hand cases case suffered bar allergy implant metal groups respectively needing groups respectively surgery month serum levels esr crp higher group group non infected patients comparatively serum levels esr crp significantly higher group group infected patients conclusion stainless steel coated chitosan provides safer effective material repair reducing metal allergies infection rates rates
runtime analysis black box search algorithms provides rigorous performance guarantees algorithm design comparison unfortunately deriving bounds challenging result existing literature focused algorithms parameter less population recently proposed unbiased black box search algorithm combines local search model based mixing population empirical studies outperformed leading genetic algorithms across variety problems provide runtime analysis bit problems help light reason effectiveness derive upper runtime bounds linear functions log size simplified version obtain bound log results show competitive best known unbiased genetic algorithms problems suggesting performance furthermore find effectiveness relies three major components support algorithms design
testosterone mediates several key aspects male reproduction maintaining high testosterone levels reduce long term survival one proposed pathways testosterone influence survival increased risk parasite infection hormone potential affect transmission sexually transmitted infections promoting behaviours increase sexual contact rates decreasing immune function hypothesized males high concentrations testosterone increase chances infected sexually transmitted bacteria manifest increased diversity bacteria test hypothesis measured circulating testosterone concentrations breeding male collected quantify bacterial diversity using rrna gene sequencing positive correlation testosterone concentrations phylogenetic diversity bacteria addition individuals high medium testosterone concentrations bacterial communities similar low testosterone individuals finally considering bacterial taxa potential avian pathogens found relative abundance class intracellular parasites positively correlated testosterone concentrations two non exclusive explanations results testosterone affects behaviours lead increased sexual contacts thus exposure acquisition additional diverse bacteria testosterone altering immune system environment thus making easier bacteria either way data suggest increased exposure sexually transmitted pathogens form bacteria cost maintaining high testosterone levels
comprehensive characterization raw data format imagery acquired camera module presented high performance single board computer designed educate solve real world problems small computer supports camera module uses cmos sensor paper shows scientific engineering grade imagery produced camera module raw imagery shown linear exposure gain iso essential scientific engineering applications dark frame noise exposure stability assessments along flat results spectral response measurements absolute calibration results described low cost imaging sensor calibrated produce scientific quality data used computer vision remote sensing high dynamic range imaging security applications name authors published spie creative attribution license distribution reproduction work whole part requires full attribution original publication including
background reduction sugar intake beneficial weight management related health conditions however knowledge data exist regarding spontaneous changes dietary components overall dietary quality reduction intervention objectives explored longitudinal changes within reduction intervention physical activity intervention respect spontaneous changes energy intake dietary quality healthy eating index categories design participants enrolled community based behavioral trial randomly assigned either intervention group matched contact comparison group dietary intake assessed mean three dietary baseline dietary analyzed use nutritional analysis software multilevel mixed effects linear regression intention treat analyses presented results participants showed significant reduction total mean decrease several spontaneous changes occurred within group compared group included significant improvements empty total vegetable total scores mean increases respectively additional positive changes shown including significant decreases total energy intake trans fat added sugars total energy dietary changes noted group intervention conclusions intervention single dietary component resulted additional spontaneous beneficial dietary changes interventions target single dietary change limiting intake improve overall dietary quality health provide motivation make additional dietary changes
purpose review availability childrens health exposure assessment resource funded national institute environmental health sciences provides new opportunities exploring role tobacco smoke exposure causing harm children recent findings children smokers exposed nicotine harmful tobacco smoke chemicals utero environment passive exposure tobacco smoke variety negative effects children utero exposure tobacco smoke causes poor birth outcomes influences lung cardiovascular brain development placing children increased risk number adverse health outcomes later life obesity behavioral problems cardiovascular disease furthermore smokers start adolescence age increased nicotine addiction risk biomarkers tobacco exposure helps clarify role tobacco chemicals play influencing health childhood beyond although electronic cigarettes cigarettes appear nicotine delivery device reduced harm appears gateway use cigarette smoking adolescents summary pediatric researchers interested elucidating role tobacco smoke exposure adverse outcomes children incorporate biomarkers tobacco exposure studies
published findings journal role prenatal exposure acid behavioral outcomes treated rat pups authors show treated pups displayed subtle differences behavior including seeking novel object recognition locomotor activity others previously proposed infusion rat represent valid animal model asd since many diagnostic criteria disorder spectrum manifest conditions pathogenic gut microbiome facilitate growth microbes capable producing like species proposed infectious contributing etiology model asd however reason pathogenic microbial clear discussion highlights previously identified novel environmental factor oxide asd related altered metabolism asd represent key manifestation particular exposure trace environmental exposure induce release endogenous opioid peptides shown confer virulence advantage certain microbes like pseudomonas aeruginosa pathogenic asd compensatory mechanism enhanced virulence potential therefore future research model asd consider role consequence environmental exposure published elsevier ltd rights reserved
since centers medicare medicaid services cms distributed quality star ratings medicare advantage contracts better inform medicare eligible individuals plan quality paper examines extent quality star rating scheme affected behavior market identify causal effect star ratings using regression design exploits random variation around threshold values underlying star rating calculations find contracts higher star ratings significantly increased average monthly relative contracts just respective threshold values increases per month among star contracts present additional evidence estimated increases purely result demand shifts prior year furthermore star ratings significant effect plan mix star contracts disproportionately dropped plans star contracts disproportionately expanded plans new markets particularly plans positive monthly broadly analysis reveals relatively large supply side response published quality ratings suggesting level caution policy makers extend quality rating systems new health care markets
due ever increasing efficiency computer systems symmetric becoming vulnerable linear force attacks example des short key bits becoming easier break aes much longer key size bits makes difficult crack using even advanced dedicated computers however complex algorithms exhibit better confusion diffusion characteristics always required algorithms stronger resistance differential linear attacks paper describes development algorithm implements pseudo random number generator order increase key generation complexity experimental results des aes complemented shown average improvement error computation original standard systems considerable improvement time complexity systems
activation canonical related integration site wnt beta catenin signaling pathway associated malignant transformation development fibrosis angiogenesis analyzed beta catenin mrna expression bone marrow patients primary pmf secondary myelofibrosis control participants using quantitative real time polymerase chain reaction qrt pcr beta catenin expression increased pmf anemia introduction beta catenin central effector molecule canonical related integration site wnt signaling pathway important maintenance stem cell homeostasis aberrant activation implicated wide array malignant hematological disorders reports suggesting dysregulation philadelphia chromosome negative myeloproliferative neoplasms mpns patients methods analyzed beta catenin mrna expression bone marrow patients primary pmf patients secondary post mpn myelofibrosis using quantitative real time polymerase chain reaction qrt pcr control group consisted patients limited stage aggressive non hodgkin lymphoma without involvement compared relative gene expression clinical hematological parameters results relative expression catenin differed significantly among groups significantly higher patients pmf control group differ patients pmf negative correlation found regarding hemoglobin level pmf association according janus kinase mutational status allele burden detected conclusion results show first time beta catenin mrna expression increased patients pmf upregulation anemia number inflammatory cytokines associated pmf capable mediating effects increased beta catenin expression accordingly beta catenin induce expression number genes implicated processes cell cycle control fibrosis angiogenesis central pmf pathogenesis therefore beta catenin represent interesting new therapeutic target diseases
kernels continuous version traditional coordinates used define values given smooth planar contour data two dimensional boundary planar map kernels conveniently expressed using complex number algebra simplifying much results paper develop basic complex valued algebra needed describe planar maps use define similarity kernels natural alternative usual kernels develop theory behind similarity kernels explore properties show versions popular three point coordinates laplace mean value surprisingly simple similarity kernels furthermore show similarity kernels used mappings using iterative algorithm quite rapidly useful rendering images deformed planar mappings
pneumonia relatively rare complication non hiv patients receiving immunosuppressive treatment since introduction tumour necrosis factor inhibitors cases complication increased report case year old hiv negative patient presented department long history psoriasis poor response traditional treatments last admission developed severe therefore infliximab initiated third dose developed required admission intensive care unit positive response administration follow mutation gene compatible deficiency found started rapid improvement psoriasis severe complication patients receiving immunosuppressive therapy probably dermatologists clinical guidelines prophylaxis dermatological patients receive immunosuppressive biological treatments believe necessary report cases assess real impact complication develop appropriate prophylaxis guidelines
article discusses characteristics several concepts suitable use purely electric vehicles attention paid given system affects driving dynamics vehicle especially overall drive efficiency based defined driving cycle introduction presents specific types powertrain used modern mass produced electric vehicles following sections describe properties selected devices demonstrated using example high performance virtual electric motor dependence available effort acceleration overall efficacy powertrain one two motors depicted graphically
paper presents novel realization voltage mode first order pass filter circuit composed single universal voltage conveyor single capacitor three resistors proposed filter provides inverting non inverting outputs configuration simultaneously high input low output desired easy voltage mode operations circuit suitable wideband applications theoretical results verified spice simulations using tsmc cmos process parameters furthermore experimental measurements using integrated circuit
biomass widely used renewable energy source world today used mostly solid form lesser extent form liquid fuels gas utilization biomass energy production increased modest rate modern times biomass major source energy rural turkey biomass used meet variety energy needs including generating electricity heating homes vehicles providing process heat industrial facilities biomass potential includes wood animal plant wastes among biomass energy sources fuel wood seems interesting share total energy production turkey high total biomass energy potential turkey million oil equivalents amount usable biomass potential turkey approximately electrical production potential usable sources corporate income represent jobs study shows important biomass energy potential climate change mitigation energy sustainability turkey elsevier ltd rights reserved
uncertainty neural model influences effectiveness neural model based systems application approach state space neural model structure selection allows reducing model uncertainty state space representation neural model enables develop new technique estimation neural model inputs based result enables performing robust fault detection isolation actuators
economic situation highlights significant role application computer human society since century especially since thesis probes security risk propagation immune mechanism complex network background focusing issue network security network background thesis analysis adopting mechanism model immune mechanism parts nodes establishing stochastic immune mechanism security risk introducing stochastic immune mechanism propagation model security risk study security risk propagation immune mechanism complex network background thesis presents model rules introduces security risk immune mechanism establishes models immune mechanism finally simulation experiments simulation results characteristics security risk propagation model study stochastic immune mechanism propagation model immune mechanism stochastic model thesis reaches conclusion initial stage propagation die rate security risk inversely proportional propagation rate
non small cell lung cancer nsclc number one cause global mortality despite aggressive treatment prognosis patients advanced nsclc median survival months time diagnosis molecularly based approaches drug discovery yielded tyrosine kinase inhibitor significantly median progression free survival subset patients although initial clinical trial results demonstrate promising role play nsclc treatment development resistance leaves much elucidated effectively combat disease review follow discovery development bench provide example successful bottom drug design explore clinical trial results fast tracked eventual use therapy sensitive nsclc patients development resistance lastly discuss potential future uses within beyond nsclc
measurement analysis low level vibrations acoustic emissions components structures often accomplished utilisation multiple distributed piezoelectric sensors frequencies interest usually upper audio range khz typically ultrasonic frequencies measurements intrinsically limited terms dynamic range due signal noise ratio overall system comprising transducer front end signal amplification together associated interconnection cables paper demonstrates latest bipolar operational amplifier technologies rather traditional technologies provide better solution higher frequencies ultra low noise systems whilst still delivering high gain bandwidth needed paper also presents comparative noise analysis three principle operational amplifier circuit topologies commonly utilised piezoelectric sensors single ended charge amplifiers differential charge amplifiers voltage mode amplifiers effects transducer cables system configuration also considered noise perspective theoretical analysis verified practical experiment
patients cancer often experience high symptom burden prior start treatment disease treatment related appear additive targeting disease related symptoms attenuate overall symptom burden cancer patients improve tolerability treatment hypothesized disease related symptoms consequence tumor induced inflammation tested hypothesis using murine model human virus hpv related head neck cancer model advantage aggressive causing weight loss previously showed tumor leads increased beta tnf alpha expression liver increased beta expression brain current study confirmed features demonstrated tumor exhibits high inflammatory cytokine expression beta tnf alpha compared healthy tissue clear relationship cytokine levels behavioral deficits model behavioral changes surprisingly mild therefore sought confirm relationship behavior inflammation effect using low dose lipopolysaccharide lps tumor bearing mice lps induced deficits building tail suspension locomotor activity approximately lps however mice display exacerbation lps induced weight loss anorexia heightened serum observed minimal priming liver brain cytokine expression next sought inhibit tumor induced deficits reducing inflammation using similar day drinking water able attenuate tumor induced inflammation deficits data provide evidence favor inflammatory like mechanism behavioral alterations associated tumor growth murine model hpv related head neck cancer however inflammatory state behavioral changes induced tumor clearly differ forms inflammation induced behavior elsevier ltd rights reserved
objectives aim systematic review provide overview evidence effectiveness brief interventions targeting mental health organizational settings compare effects corresponding interventions common longer duration methods extensive systematic search conducted using medline psycinfo databases period randomized controlled trials rct quasi experimental studies evaluating primary secondary brief interventions carried workplace settings included subsequently common interventions matching brief interventions type assessed outcomes included methodological quality included studies using guidelines best evidence synthesis approach applied results review identified brief interventions corresponding common interventions included studies varied substantially sample size characteristics methodological quality duration follow types intervention assessed outcomes one study evaluating brief interventions high risk bias evidence found effectiveness brief stress management relaxation mindfulness multimodal interventions found limited evidence effectiveness brief positive psychology interventions conclusions review highlights need high quality studies evaluating brief mental health wellbeing interventions organizational settings future studies use rigorous designs improved reporting methods results provide conclusive evidence effectiveness sustainability intervention effects
article deals circuit characterization point view filter based concept piecewise linear functions furthermore experiments developed teaching electronic systems used novel filtering concepts frequency range tested khz due audio spectrum comprised frequency range node associated capacitor diode used input node another capacitor coil used output thereby establishing one input output relationship system case given piecewise linear functions experimental result shows circuit behaves filter amplifier maximum frequency around khz bandwidth khz khz results presented paper motivate engineering students pursue applications novel electrical circuits based topics potential interest future research studies
autism global phenomenon yet dearth knowledge understood impact low income countries examined parents professionals understanding autism one low income country conducted focus groups semi structured interviews parents autistic non autistic children education health professionals urban rural settings asking questions typical atypical development presenting children prompt discussion overall parents typically developing children professionals little explicit awareness autism however use distinctive terms describe children autism children developmental conditions furthermore participants felt environmental factors including utero stressors birth complications parenting style home school environment key causes atypical child development called greater efforts raise awareness build community capacity address autism first study show striking lack awareness autism parents professionals alike results important implications future work aiming estimate prevalence autism enhance support available autistic children families
objectives determine incidence hypogonadism men human immunodeficiency virus hiv acquired immunodeficiency virus aids useful serum testosterone measurement threshold diagnosing hypogonadism comparative efficacy testosterone replacement therapy laboratories pharmaceuticals inc design subjects stage observational study stage patient records medical practices hiv aids reviewed eligible patients aged years hiv seropositive status confirmed enzyme linked immunosorbent assay western blot test hiv confirmed hiv rna polymerase chain reaction prior baseline testosterone assessments hypogonadism presence signs symptoms hypogonadism total testosterone free testosterone level measurements stage included evaluation patients stage treated day stage inclusion criteria diagnosis low testosterone defined level level per endocrine society guidelines presence absence signs symptoms months sign symptom assessments level measurements either weeks initial initial switched discontinued results four hundred one patients met stage inclusion criteria patients met stage inclusion criteria total testosterone level alone identified patients failed diagnose additional patients levels symptoms month increased mean levels levels compared respectively patients treated showed significantly greater improvements sexual performance energy focus concentration abdominal trends greater improvement fatigue erectile dysfunction patients treated patients discontinued therapy due adverse events conclusion useful serum testosterone measurement threshold diagnosing hypogonadism men hiv aids level symptom currently accepted thresholds criteria using level level diagnosed patients respectively hypogonadism effective increasing levels improving symptoms
brain network alterations patients alzheimers disease subject much investigation biological mechanisms underlying alterations remain poorly understood aim identify changes brain networks patients mild cognitive impairment mci provide accurate algorithm classification patients healthy control subjects using graph theoretical approach advanced machine learning methods multivariate causality analysis performed resting state functional magnetic resonance imaging fmri data mci calculate various directed graph measures graph measures used original feature set machine learning algorithm filter feature selection methods applied original feature set select optimal subset features accuracy achieved classification mci using optimal features naive bayes classifier also performed hub node analysis found number mci respectively suggesting patients experience disturbance critical communication areas brain network progresses findings study provide insight neurophysiological mechanisms underlying mci proposed classification method highlights potential directed graph measures fmri data identification early stage elsevier rights reserved
post weaning feed restriction common practice rabbit farming reduce mortality results lower growth performance weights study aimed assess influence diets rich fibre low starch high low energy protein contents constant ratio offered age growth performance health parameters rabbits eight hundred rabbit kits divided experimental groups differing feed offered high concentrate diet group low concentrate diet group feed offered weaning feed offered controlled obtain similar intake groups feed intake animal weights health status recorded weekly mortality recorded daily feed intake similar groups weaning consequently intake higher group compared group weaning respectively feed intake lower group kit respectively total ingested weaning similar groups kits group throughout study higher average daily gain periods seen group respectively mortality morbidity rates similar groups throughout study respectively results suggest feed intake weaning controlled feeding strategy weaning determines weight weaning age rabbits fed diet highly concentrated rich fibre increase growth performance without negative consequences digestive health
many water related human interventions modify natural hydrological systems watersheds rainwater harvesting rwh intervention involves harnessing water water harvesting used upstream prevents surface runoff downstream impacting biodiversity ecosystems main objective study assess effects water harvesting technologies downstream water availability district ethiopia soil water assessment tool model cost benefit ratio optimal control approach used analyze hydrological socioeconomic impact trade offs water availability community respectively downstream impact increasing water consumption upstream areas watershed simulated using semi distributed model two land use scenarios tested sub basin levels conventional land use represent current land use practice con rainwater harvesting improving soil water availability rwh land use scenario simulated water balance results showed highest peak mean monthly direct flow obtained con land use followed land use scenario reduced direct flow compared con groundwater flow contributed con overall result suggests water yield area negatively affected land use scenario technology district benefited positively average cost benefit ratio storage tanks series check dams gravel filled dams alternative solutions water harvesting
objective although reducing pain shown contribute functional improvement patients receiving interdisciplinary pain care little known changes different dimensions pain uniquely contribute improvement outcome study examined unique relationship changes distinct factors pain rumination changes pain methods study patients completed treatment week interdisciplinary pain rehabilitation program years completed battery validated measures pain pain severity pain interference mental physical health related quality life depressive symptoms pretreatment series within groups repeated measures mediation analyses conducted change rumination subscales entered multiple mediators model analyses revealed change partially mediated improvement outcome variables beyond influence change variables model whereas change rumination partially mediated improvement pain severity interference depressive symptoms change least impact outcome partially mediating improvements mental health quality results suggest changes dimensions pain differentially mediate improvement pain outcome treatment approaches specifically target rumination particularly useful improving outcomes patients refractory pain conditions enrolled interdisciplinary pain rehabilitation program
chimeric mice constructed human hepatocytes useful predicting human metabolism drug candidates study investigated whether mice show similar metabolic profile humans examining warfarin reported mainly metabolized warfarin catalyzed humans warfarin administered chimeric mice control upa mice blood concentration time curve higher chimeric control mice plasma protein binding warfarin chimeric control mice respectively warfarin administered mice mainly recovered urine chimeric mice control mice warfarin administered mice recovered bile chimeric control mice respectively main urinary metabolite chimeric mice warfarin main urinary metabolite control mice results show mass balance metabolic disposition warfarin chimeric mice humanized liver similar reported human data
acquired comprised quasi sinusoidal oscillations eyes significantly affecting gaze holding clarity vision common causes acquired include demyelinating disorders multiple sclerosis syndrome ocular however several deficits pharmacological metabolic genetic disorders disorders lead syndromes mimicking acquired study kinematic features acquired suggested putative pathophysiology otherwise neurological disorder review clinical features neurological deficits occur acquired subsequent discussion pathophysiology individual forms mechanisms underlying disease providing insights pharmacotherapy elsevier rights reserved
today development information communications technologies changed utility landscape dramatically particular electricity distribution networks rely heavily multitude intelligent systems devices communicate among much advanced ways past smart grid becoming nowadays critical component electricity delivery system important make grid equipped adequate security mechanisms able guarantee reliable operation real time information exchange within power infrastructure therefore paper analyze critical aspects associated smart grid services including previous cyber attack cases smart grids potential vulnerabilities threats advanced strategies smart grids technical management measures ultimately service providers continuously enhance traditional security measures authentication access control data encryption public key infrastructure log analysis intrusion detection systems network security protocols propose advanced technical measures make smart grids even cyber attacks internal failures employ defense depth approach employ defense depth approach provide scalable security measures furthermore also propose advanced management measures establish governance strategy develop strong incident response plan culture security employ public private partnership approach comply widely recognized security standards
unique system integrating biogas fed solid oxide fuel cell solar thermal system reference waste water treatment plant italy proposed biogas locally anaerobic digestion collected sludge used produce electricity using power modules thermal power recovered exhaust stream used meet part thermal load however rest heat loads provided using integration system auxiliary energy analysis performed determine effect using solar heating system system performance also economic performance evaluated flow analysis calculation cost electricity observed installing solar collectors cover total heat load respectively results show overall beneficial effect solar installation energy economic view scenarios analyzed lower grid electricity price increasing solar integration value reduced showing despite investment return time electricity production entire system lifetime competitive grid electricity prices elsevier ltd rights reserved
polycythemia vera myeloproliferative disorder characterized excess red cell increased number red blood cells lead increased viscosity blood ultimately compromise blood supply end organs thromboembolic hemorrhagic complications also develop patients presenting neurological diseases require surgical intervention increased risk due various factors immobility prolonged surgical time dehydration report management patient underwent intervention excision
background mutations calr reported key markers molecular diagnosis myeloid proliferative neoplasms previous reports calr mutations analyzed using sanger sequencing report new rapid convenient system screening calr mutations without sequencing methods eighty three bone marrow samples obtained patients pcr primers designed detect wild type calr product calr type product type mutations product one reaction results confirmed sanger sequencing compared results fragment analysis results minimum detection limit screening pcr type type cases mutations calr type type mutants detected screening pcr maximal analytical sensitivity respectively screening pcr detected mutation cases showed concordant results sequencing cases type type mutations sanger sequencing identified one novel mutation compared sequencing screening pcr showed sensitivity specificity positive predictive value negative predictive value compared fragment analysis screening pcr presented sensitivity specificity conclusions screening pcr rapid sensitive cost effective method detection major calr mutations
study aims assessing technical economic benefits existing public housing four representative federal public housing built modeled analyzed integrated environmental solutions virtual environment energy modeling software used estimate energy consumption savings due different configurations applied technical configurations based green buildings sustainability assessment system configurations include three elements wall roof insulation replacing annual electricity savings results indicated cost efficient strategy wall insulation savings followed roofs insulation savings lastly replacing savings three elements simultaneously savings achieved model savings translated emission reduction year simple payback periods different configurations tested ranged years respectively
attack elastic optical networks new objective criterion security strategy extended routing spectrum allocation algorithm proposed simulation results shows better security guarantee resource utilization provided
background seasonal influenza responsible high annual morbidity mortality worldwide especially elderly patients aim study analyse epidemiological clinical prognostic features influenza admitted general hospital risk factors associated mortality methods retrospective cross sectional descriptive study patients admitted diagnosed influenza molecular biology general university hospital january april results total patients diagnosed influenza study period years episodes caused influenza patients aged years older lower glomerular filtration rate mean min min greater need non invasive mechanical ventilation greater morbidity due cardiac insufficiency chronic renal disease greater mortality multivariate analysis mortality higher aged adjusted odds ratio confidence interval acquired long term care facility conclusions seasonal influenza serious problem leading elevated mortality patients admitted general hospital
function robot living together problem communication focus nonverbal communication relationship service robots human show nonverbal communication experiments robot build relationship human described ideal robots live got experience relationship based touch communication managed three elements appearance motion predictable behavior result elements based human robot feeling safe natural motion motivation build relationship robots decided three elements physically appearance motion important evaluation relationship complicated relationship grows depending spending time motivation relate experiences shown life sized robot robot arm based results evaluation method understand relationship robot human considered near future robot development
purpose study analyze differences two running styles foot first foot ball foot comes running styles compared term vertical mathematical model parameters motion analyzed data ground reaction forces measured force platform subjects performing style running various velocities ranging unique set parameters model trial computed nonlinear programming minimize sum relative standard error ground reaction force relative error velocity motion analyzed data measured high speed motion capture system differences running styles considered using results parameters multi degree freedom model motion analysis results study indicate needs less energy contact style impulse internal forces also indicates ratio upper lower mass vertical mathematical model higher previous study also showed effective mass related first peak ground reaction force smaller reason reduce risk running injuries injuries hip knee ankle joints reducing impact body authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering university
specification tightly binds command specific device best performance user find ideal device mapping command creation time effort requires thorough understanding underlying device architectures kernels program paper propose add scheduling attributes context command objects intelligent runtime automatically perform ideal mapping proposed extensions enable average focus algorithm design rather scheduling automatically gain performance without example design implement runtime task parallel workloads called efficiently schedules command across devices case studies include benchmark suite real world simulation benefit runtime optimizations users apply proposed extensions four source lines code average existing applications evaluate single node experiments also compare closest related work show maps command optimal device set cases negligible runtime overhead elsevier rights reserved
paper introduce simple effective algorithm detect image precise location moving targets behind obstacles based one transmitter two receiver configuration problem geometry together formulation details algorithm given performance algorithm first evaluated synthesizing numerical scenario simulated moving ideal success validity algorithm assessed error analysis study calculates error associated approximations algorithm tested measured data obtained experimental set detecting human movement behind wall resultant two dimensional consecutive images indicate algorithm effectively used moving targets similar obstacle radar applications good fidelity wiley periodicals inc
mycobacterium tuberculosis produces activates cells upon binding mhc like antigen presenting molecule tuberculosis produces trace amounts previous solid phase synthesis provided sub quantities describe high yielding solution phase synthesis features substitution avoids yield limiting lysine conditions prevent double bond acyl chain provides material equivalent natural varied central lysine acyl chain compared ability recognised restricted cell receptors derived unrelated human donors exhibited similar spectrum reactivity towards panel highlighting sensitivity reactive cells natural
due combination factors environmental concerns high oil prices potential peak oil development alternative fuels advanced power systems vehicles become high priority many governments vehicle manufacturers around world use gasoline alternative fuel gasoline engine becoming need looking scarcity petroleum fuels near future paper investigates influence compression ratio ethanol gasoline blending find effects four stroke engine performance research air cooled engine compression ratio used fuel blend used study engine operated speed range rpm maximum power obtained fuel compression ratio minimum fuel consumption rate obtained compression ratio clearly compression ratio increases fuel consumption rate decreases considerably experimental results showed comparing several blends ethanol cost power effective four stroke engine
paper presents design implementation testing automation component prototype machinery cutting sorting harvested crops purposes device developed name rod result collaboration six partners four different countries rod project includes mechanical automation hydraulics sensor measurement concepts operates according conditions imposed beneficiaries short rotation farm owners agricultural machinery energy crops species producers harvested material cut diameter length restrictions sorted packages ready distribution process automated requiring little intervention behalf operator cutting accuracy speed execution two features underline efficiency device compared manual rod processing methods measurement errors obtained machine indicates manually calculated length functionality tests performed several weeks laboratory industrial conditions confirm system properly designed implemented regarding economical evaluation conclusion working machinery decrease overall processing costs approximately five times compared manual labor authors published elsevier ltd open access article license http creativecommonsorg licenses
objectives despite exponential proliferation chinese diabetes applications none designed meet needs largest potential user population purpose study examine features contents chinese diabetes mobile applications terms suitability use older adults diabetes methods search apple application store mobile conducted identify chinese diabetes applications next compared features contents included popular diabetes applications international diabetes federation clinical guideline recommended usability criteria older adults respectively results seventy one diabetes apps randomly selected pool diabetes apps reviewed features apps failed include content areas known importance managing diabetes older adults usability tested applications rated moderate good conclusions designing maximally effective medical applications benefit attention usability content guidelines targeted largest potential user population despite older adults potential user group failing consider relevance content addition usability specific population ultimately limit usefulness app elsevier rights reserved
eastern canada several spp cultivars susceptible hybrids protected soil geotextile fabric winter months practice although useful protecting winter injuries provides adverse winter conditions thus expected large proportion objective study investigate relationship fall incidence disease development following spring relationship established using data collected cultivars plots fall incidence severity assessed weekly break harvest proportion leaf area diseased harvest area disease progress curve time maximum disease rate disease progress yield estimated regardless cultivar year fall incidence significant effect progress higher fall incidence associated earlier development symptoms higher severity following spring information used determine appropriate strategy manage following spring however research needed determine management strategies adapted various levels risk
micrornas mirna implicated variety pathological conditions including infectious diseases knowledge mirnas affected poly synthetic analog viral double stranded rna porcine airway epithelial cells contributes understanding mechanisms viral respiratory diseases bring enormous economic loss worldwide every year study used high throughput sequencing profile mirna expression treated poly compared untreated control approach revealed differentially expressed mirnas five implicated viral infection nineteen mirnas downregulated including members mir cluster known extensively involved viral infection humans target genes predicted using bioinformatic methods validated luciferase reporter analysis two representative significantly enriched several pathways including transforming growth factor signaling large quantity sequence variations found including substitution position verified mirnas new spectrum targets luciferase reporter assay together bioinformatics analysis twelve novel porcine mirnas conserved species identified homology analysis together cloning verification furthermore expression analysis revealed potential importance three novel mirnas porcine immune response viruses overall data contribute mechanisms underlying host immune response respiratory viruses pigs repertoire porcine mirnas
background depression complex neuropsychiatric syndrome often severe life threatening spite remarkable progress understanding neural biology depression still elusive study investigated molecular mechanisms prefrontal cortex mice showing depression like phenotype induced chronic stress methods depression like phenotype induced mice day social paradigm metabolic activity excitatory glutamatergic inhibitory gamma acid gaba neurons prefrontal cortex measured nuclear magnetic resonance spectroscopy together infusion glucose addition expression level genes associated glutamatergic pathways monitored quantitative polymerase chain reaction results mice showing depression like phenotype exhibit significant reduction levels glutamate acetyl aspartate prefrontal cortex importantly findings reduced labeling glutamate glutamate gaba glucose indicate decreased glutamatergic neuronal metabolism neurotransmitter cycling depressed mice reduced labeling suggests decreased neurotransmitter cycling depression quantitative polymerase chain reaction analysis revealed reduced transcripts genes code enzymes involved synthesis gaba clearance glutamate synapses respectively conclusions data indicate activities glutamatergic neurons reduced mice showing depression like phenotype supported molecular data expression genes involved glutamate gaba pathways
paper presents device developed basis adjustable passive reactive power compensator intended increase power factor electric configuration contributes increase power factor working modes operation due approximation power factor value maximum possible values compensator operated method extreme voltage control autonomous voltage inverter mathematical modeling work electric equipped compensator performed matlab package showed possibility increase power factor published elsevier ltd
crop simulation models valuable tools quantifying crop yield response water strategies improve agricultural water management however applicability majority crop models limited greatly failure provide open access model source code study present open source version model simulates efficiently water limited crop production across diverse environmental conditions model called run multiple programming languages operating systems support parallel execution reduces significantly simulation times applying model large frameworks long run policy analysis uncertainty assessment furthermore compliant open modelling interface standard facilitating linkage disciplinary models example guide integrated water resources planning author published elsevier
objective explore subjective quality life qol children syndrome china provide basis effective interference method total patients controls enrolled subjective qol investigated inventory subjective life quality family environment scale chinese version global severity scale case control study performed results total score subjective qol family life school life peer relationship cognitive component environment self awareness cognitive component depression experience lower control patients morbid exhibited significantly lower scores within subjective qol family life peer relationship school life self awareness cognitive affective domains conclusion subjective qol impaired important control clinical symptoms improve family environment improvement subjective qol
objective compare outcomes percutaneous immunocompromised patients healthy population patients methods matched case control study performed january december using prospectively collected kidney stone database patients positive human immunodeficiency virus hiv hepatitis cellular immune dysfunction patients high dose immunosuppressive drugs treatment autoimmune diseases composed case group control group included patients kidney comorbidity patients randomly matched based score surrogate case complexity results sixty two patients enrolled study cases controls significant differences age gender body mass index groups regarding technique differences patient positioning number operative time complication rate higher case group however major complications defined score statistically different tendency postoperative urinary tract infection case group mean decrease hemoglobin level blood transfusion rate significantly higher case group immunocompromised patients fold increased risk complications odds ratio confidence interval fold increased risk blood transfusion differences stone free rate tube time length hospital stay conclusion immunocompromised patients higher risk complications bleeding
geosynthetics commonly used reinforcement layers bridge underground support upper soil mass applications geosynthetics acting membranes plus effect soil maintain stability mitigate soil study including two dimensional experimental testing subsequent numerical simulations investigates soil mass deformation geosynthetics experimental study performed fabricated container bottom one lowered mimic cylindrical aluminum bars used soil experimental testing two dimensional situations layer geotextile placed soil fill serve reinforcement following experimental test numerical simulation carried using discrete element method extend scope experimental study results indicated deformed shape geosynthetic layer approximately parabolic decreased vertical direction lateral influence range appeared bounded two lines inclined degrees phi friction angle showed significant influence tension geosynthetic elsevier ltd rights reserved
leverage data structures guarantee correctness completeness query results encrypted data contribution bridging two independent lines work encryption data resulting general purpose technique without increasing client storage overhead small data structure added server side comparison base encryption without mechanisms determining result integrity data structure simultaneously also used integrity stored data elsevier rights reserved
transgenic expression gene confers resistance pathogenic strains contain gene susceptible tomato varieties gene highly conserved among members genus shares homology causal agent disease previous study showed transient expression leaves reduced formation induced plant defence mechanisms work effect stable expression gene resistance evaluated transgenic plants interestingly agrobacterium mediated transformation unsuccessful constitutive promoter used plasmid construction seven transgenic lines obtained genetic construction control pathogen inducible promoter glutathione transferase gene potato reduction disease symptoms observed transgenic lines expressing respect non transformed control plants reduction directly dependent gene since effect observed mutant strain disruption gene used additionally symptom reduction correlated levels expression transgenic plants assessed real time qpcr accompanied production reactive oxygen species results indicate resistance gene also functional family considered control
energy observed increase decreasing diameter due quantum confinement quasi one dimensional semiconductor nanostructures similar effect observed sufficiently small wire diameters induced becomes semiconductor demonstrate length scale semiconductor transition occurs enables use engineering form field effect transistor near atomic dimensions eliminates need doping transistors source channel drain removing requirement supply free carriers introducing quantum confinement allows materials engineering overcome primary obstacle sub transistors enabling aggressive scaling near atomic limits
parallel computing systems promise higher performance computationally intensive applications since programmes parallel systems consist tasks executed simultaneously task scheduling becomes crucial performance applications given dependence constraints tasks arbitrary sizes bounded resources available execution optimal task scheduling considered hard problem therefore proposed scheduling algorithms based heuristics paper presents novel list scheduling heuristic called heuristic simple yet effective scheduling heuristic differs existing list scheduling techniques way task priorities priority mechanism maintains fairness among ready tasks belonging paths within task graph conduct extensive experimental evaluation heuristic task graphs taken standard task graph experimental study includes results task graphs comprising tasks per graph execution scenarios core systems report results average schedule length ratio obtained producing variations communication computation cost ratio also analyse results different degree parallelism number edges task graphs results demonstrate produces schedules within maximum worst case optimal schedule core systems also compare existing scheduling heuristics perform comparative analysis performance outperforms existing heuristics average values
design advanced reliability piezoelectric transducer acoustic emission suggested advanced reliability achieved eliminating main reasons lead failures main operating systems redundant extended technical capabilities transducer design make possible compensate partial complete performance loss antenna group shown given design approach feasible achieve technical characteristics industrial acoustic emission transducers theoretical estimates transducer reliability presented show combination registration channels different versions connection gives ample opportunities governing reliability sensors usage service life
porcine gene play important role muscle development formation pig explore whether expression affects muscle fiber trait porcine full length cdna amplified using homology based cdna cloning smart race full length cdna porcine inserted transfected cells cells stably expressing selected examined expression slow cells stably expressing results showed level mrna dramatically increased compared control cells level slow mrna changed identify transcription events porcine mrna detected northern blotting two transcripts long transcript short transcript found porcine skeletal muscles nucleotide sequence shares homology gene human mouse deduced amino acid sequence amino acids pig shares identity human mouse respectively taken together research revealed porcine involved regulation muscle fiber trait affecting expression
background previous evidence healthy subjects suggested functional polymorphisms interact regulating mood emotional processing attempted replicate interaction primarily manic depressive dimensions mood disorder patients schizophrenia patients diagnosis age onset methods symptom dimensions derived comprehensive assessment symptoms history items rated lifetime acute episodes stabilized intervals patients schizophrenia bipolar disorder eastern study linear mixed effect models symptom dimensions included main interaction fixed effects obtained taqman genotypes random effect distribution lifetime best estimate dsm diagnosis members studied versus genotype logistic model results mood disorder patients level mania acute stabilized periods depression stabilized periods positively associated allele carriers bonferroni corrected interaction respectively two polymorphisms explained mania variance depression variance association observed neither schizophrenia patients psychotic dimension mood disorder patients interaction diagnosis distribution driven decreasing prevalence recurrent major depression also carriers limitations sample size limited power sufficient detect tested interaction effect replication sample conclusions replicate affective patients interaction polymorphisms regulating mood dimensions
one operational amplifier amp negative feedback traditional zero potential circuit access one element two dimensional resistive sensor array shared row column fashion suffered crosstalk problem non scanned elements bypass currents injected arrays non scanned electrodes zero potential firstly suppressing crosstalk problem designed novel improved zero potential circuit one amp negative feedback sample total bypass current calculate precision resistance element tested improved setting non scanned electrode zero potential circuit given example analyzing verifying performance improved zero potential circuit secondly improved effects different parameters resistive sensor arrays readout circuits measurement accuracy simulated part features improved circuit verified experiments prototype circuit followed results discussed conclusions given experiment results show improved circuit though requires one amp one resistor one sampling channel access resistive sensor array accurately
paper presents new design low cost two channel type interface circuit interface circuit enables connecting microcontroller make accurate temperature measurements degree degree resolution usage computational capabilities proposed make adaptive self calibration designed interface circuit capabilities also used solve two major problems associated signal measurement non linearity problems reference junction problems
dual assignment clustering dac recently proposed computer vision shown yield improved accuracy action clustering tasks key idea dac consider another view different original features set samples exploit statistical correlation cluster assignments two views however existing optimization heuristic mainly due difficulty combinatorial optimization hard cluster assignment paper introduce novel dac optimization algorithm based probabilistic soft treatment proposed objective function incorporates clustering view correlation two views theoretically sound fashion also propose lower bound maximization technique fast per iteration solutions also guarantees convergence local optimum superiority proposed approach existing methods demonstrated several activity video datasets elsevier inc rights reserved
vaginal associated symptoms occur women age frequent burden menopause north american menopause society recommends long acting non hormonal vaginal first line therapy new type developed germany hormone free cream contains established vaginal cream ingredients explored physical function tolerability open interventional clinical trial postmenopausal women years median treated vaginal using cream daily days reported symptoms first last application physician assessed tolerability local physical function patients completed study local physical function significantly improved baseline mean normal moisture level average first last application subjective assessment feeling vaginal showed significant improvement times onset duration feeling reported min application women reported vaginal baseline patients reported first application end investigation cream seen application site tolerability assessments reveal relevant change time four adverse events patients serious mild intensity urinary urgency diarrhoea mild first application latter caused dry surface avoided surface subsequent applications conclusion study results indicate tolerated long acting function new vaginal cream clinical research patients follow
creep curve geosynthetic assays requires long time conventional tests reduce time used isothermal method known accelerated test paper presents results accelerated conventional tests assess creep geotextile non woven short fiber compared literature results showed less variability temporal range accelerated creep curves
robust control technique proposed address problem trajectory tracking autonomous ground vehicle technique utilizes fractional order proportional integral derivative controller control non autonomous ground vehicle track behaviour predefined reference path two controllers designed control inputs inputs represent torques used order manipulate implemented model vehicle obtain actual path implemented model non autonomous ground vehicle takes consideration kinematic dynamic models additional particle swarm optimization pso algorithm used optimize controllers parameters optimal tuned parameters controllers minimize cost function used algorithm effectiveness validation proposed method verified different patterns reference paths using matlab simulink software package stability fractional order system analysed also robustness system conducted adding disturbances due friction wheels vehicle motion obtained results controller show advantage performance technique terms minimizing path tracking error complement path following
cell driven inflammatory disease major public health concern cis acting element site locus control region essential regulation cytokine genes however role allergic airway inflammation underlying molecular mechanisms regulation poorly understood sought understand role development allergic airway inflammation molecular mechanism cytokine expression methodswe used induced allergic inflammation model deficient mice examine role process examine molecular mechanism cytokine expression used dna affinity chromatography mass spectrometry quantitative pcr elisa intracellular cytokine staining chromatin immunoprecipitation immunoprecipitation caused dramatic resistance allergic airway inflammation recruited transcription factors play important roles expression three cytokine genes deficiency caused inhibition transcription factor induced cytokine gene expression critical regulatory element allergic airway inflammation coordinate regulation cytokine genes
aims proteins meant elimination primary method eukaryotic cellular protein degradation ubiquitin carrier protein key degradation enzyme highly expressed many tumors however expression prognostic significance brain glioma still unclear aim study reveal level relates prognosis brain glioma methods thirty low grade high grade brain glioma samples divided two tissue microarrays levels protein examined immunohistochemistry immunofluorescence quantitative real time polymerase chain reaction used analyze level glioma normal brain tissue samples relationship levels prognosis analyzed kaplan meier survival curves results levels low normal brain tissue samples high glioma nuclei levels gradually increased glioma grade increased ectopic levels high grade glioma significantly higher low grade glioma year survival rate glioma patients high levels shorter patients low expression furthermore year survival rate patients ectopic significantly shorter patients nuclear conclusions results suggest higher levels especially ectopic associated higher grade glioma shorter survival levels play key role predicting prognosis patients brain glioma
background protein protein interactions offer compelling evidence protein function especially viewed context proteome wide bacteria popular subjects studies six different bacterial species subjects comprehensive studies several substantial segments screened interactions protein several bacterial species completed including several prominent human pathogens availability data brought challenges large data sets difficult compare across species limiting usefulness broad studies microbial genetics evolution results study use unique protein protein interactions across different bacterial species strains determine conservation across data sets taxonomic groups proteins groups resulting meta still includes interactions involve proteins unknown function conserved interactions provide support protein function respective species data found similar available data conserved two species rendering cross species comparison immediately useful meta serves model predicting interactions protein functions even full sizes species limited experimentally observed ppi including bacillus salmonella predicted respectively conclusions course work assembled cross species comparisons allow researchers anticipate structures yet unexplored microbial focus conserved yet study conserved interactions provide evidence important yet aspects bacterial physiology provide targets anti microbial therapies
baby new systematic abuse structures promoting infant trafficking neo exploitation young women unwanted pregnancies nigeria since practice first described growing rather paper reviews scientific literature along media reports phenomenon childrens rights perspective children born baby various civil rights also suffer abuse baby consequence born places abuse classified immediate long term immediate abuse includes inadequate care denial birth registration illegal adoption long term delayed abuse exposed includes health related consequences neglect death child labour sexual abuse organ trafficking recruitment child various factors thought drive baby factory phenomenon include poverty high infertility rates local inter country programmes directed addressing root cause problem needed order eliminate infant trafficking also clear laws delineate inter country adoption infant trafficking need importantly baby need recognised child trafficking routes copyright john wiley sons ltd
objective current estimate prevalence rates mental disorder among canadian federal offenders required facilitate treatment delivery service planning method study determined prevalence rates major mental disorders among newly admitted male offenders entering federal system canada data collected regional reception site consecutive admissions month period lifetime current prevalence rates estimated using structured clinical interview dsm axis disorders scid scid axis disorders scid degree impairment estimated using global assessment functioning scale results results national prevalence rate current mental disorder highest rates alcohol substance use disorders however half participants met lifetime criteria major mental disorder alcohol substance use disorders antisocial personality disorder thirty eight percent met criteria current mental disorder one substance use disorders fifty seven percent offenders current axis mental disorder rated experiencing minimal moderate functional impairment based indicating participants require intensive psychiatric services conclusions results underscore challenge posed canadian federal corrections providing necessary mental health services assist management rehabilitation significant percentage population mental health needs estimation des prevalence des les est des des services determine les prevalence des les federal canada les centre regional reception les admissions les prevalence les dsm scid les scid les par prevalence national mental les les plus lies substances des participants mental les substances cent mental substances cent des mental des participants services conclusions pose canada services rehabilitation population des des
chinese medicine recognized popular complementary medicine world abundance healing knowledge transmitted enriched generation generation recorded chinese medical knowledge grown developed detailed theory philosophy together comprehensive subtle system diagnosis recently internet quite often used variety applications medical purpose provide real time platform independent access build share knowledge clinical diagnosis experiences diseases treatments even prescriptions respect real need intelligent system chinese medical physician education chinese medicine evolved complex methods diagnosis treatment tailored individuals subtle patterns allows treat fully manifest diseases also assist maintaining health balance prevent illnesses occurring ontologies become important mechanism build knowledge based systems role ontologies capture domain knowledge provide commonly agreed upon understanding domain advantages include sharing use knowledge better engineering knowledge based system respect acquisition verification maintenance paper propose framework intelligent disease diagnosis system named chinese medical diagnostic system medical ontology integrated system development methodologies implementation digestive health uses web interface expert system technology act human expertise diagnose number digestive system diseases besides efficiently elicit knowledge digestive system domain experts construct medical ontology hybrid knowledge acquisition strategy proposed provides truly precise analysis digestive system disease prototype system diagnose types diseases amongst species primary digestive system just uses rules images various diseases satisfactory performance system proven serve educational purpose act role functionality extended whole body health system elsevier ltd rights reserved
aim unit recently shown sacral nerve stimulation significantly positive short term effect selected patients diarrhoea predominant mixed irritable bowel syndrome ibs aim present prospective study evaluate medium term efficacy ibs establish whether future role treatment ibs method patients ibs previously implanted permanent part randomized controlled crossover study assessed medium term follow primary end point change ibs specific symptom score gastrointestinal symptom rating scale irritable bowel syndrome version questionnaire baseline year follow secondary end point change ibs specific quality life score irritable bowel syndrome impact scale questionnaire baseline year follow results patients eligible year follow median ibs specific symptom score significantly lower year follow range baseline effect observed symptom clusters within score also median ibs specific quality life score significantly improved year follow compared baseline effect observed domains score per protocol patients judged therapeutic successes seventy per cent patients reduction daily ibs symptoms conclusion medium term follow continues effective treatment highly selected patients diarrhoea predominant mixed ibs
rate based steady state model absorption amp blended solution presented taking account column hydraulics mass transfer resistances chemical reactions simulation results compared experimental results absorption amp blended solution packed absorption column low high partial pressure conditions model predicts concentration amine concentration chemical enhancement factor liquid temperature profiles along column model good agreement predict concentration profiles along column low partial pressure however found model needs corrected introducing correction factor overall volumetric mass transfer coefficient simulation concentration profiles along column high partial pressure conditions range kpa elsevier rights reserved
background administrative databases increasingly used measure drug exposure perinatal aimed estimate concordance records prescriptions filled self reported drug use pregnancy methods data self reported medication use collected trimester pregnancy among sub sample organization information specialists antidepressants pregnancy cohort women eligible resident provided pharmacists contact information maternal self reports compared prescriptions filled transferred pharmaceutical services files health plan database positive negative predictive values medications taken chronically antidepressants thyroid hormones acutely antibiotics needed asthma medications calculated results among participants mean age years took least one antidepressant pregnancy according self reports according pharmacy records commonly used drugs self reported pharmacy record antibiotics asthma medications thyroid hormones chronic medication antidepressants confidence interval thyroid hormones acute medication antibiotics needed medications asthma conclusion high validate use filled prescription data large databases measure medication exposure wiley periodicals inc
energy consumption cellular networks become increasingly important cellular network operators due significant economic ecological influence networks future development alternative energy technologies resulted consideration solar powered base station long term solution mobile cellular network industry reduce operational expenditures cellular networks study addresses deployment operational issues solar powered universal mobile system third generation mobile cellular system node currently deployed node node addition study employs hybrid optimization model electric renewable software simulator developed american national renewable energy laboratory four key aspects discussed study optimal solar system architecture energy production flow solar powered node project economic feasibility solar powered system compared traditional sources simulation results show proposed solution ensures energy autonomy long term energy balance node cost effectiveness
detection micro cracks degradation strength materials early stage fracture increasing importance power plants industry methodology detecting micro cracks degradation material using quasi matrix pencil method presented paper damage represented small local elastic modulus reduction response longitudinal guided waves presence modulus reduction studied using finite element method fem damage considered using method calculate dispersion relation excited wave mode small modulus reduction detected using velocity excited guided wave time point calculated dispersion curve changing damage located method used find micro cracks material degradation early stage fracture
medical education relies heavily assessment formats require raters assess competence skills learners unfortunately often inconsistencies variability scores raters assign ensure scores assessment tools validity important understand underlying cognitive processes raters use judging abilities learners goal paper therefore contribute better understanding cognitive processes used raters representative findings social judgment decision making cognitive psychology educational measurement literature used underpinnings based assessments particular interest impact judgments referred first impressions thin slices based assessments judgments people made quickly based little information narrative review provide synthesis research three literatures social judgment decision making educational psychology cognitive psychology focus underlying cognitive processes accuracy impact first impressions based assessments application findings types based assessments used medical education reviewed gaps understanding identified suggested directions future research studies discussed
starting mini micro satellites around become one research focuses space industry different mini satellites developed early ages modern mini micro satellites widely incorporate micro electronics micro mechanisms emphasizing multi functionality system integration result relatively high power volume ratio also reduce fuel consumption application micro electrical propulsion systems mini micro satellites increasing requirement electrical power even higher hard surface mounted solar cells stationary solar arrays widely used micro satellites early ages satisfy power requirements modern mini micro satellites response requirements solar array drive assemblies used standard large gradually incorporated mini micro satellites solar arrays maximum sunlight acquisition reduce size mass solar arrays new micro integrated mechanisms electronics developed beijing institute control engineering features mechanisms electronics integrated one capsule instead separate mechanisms electronic boxes large high torque weight ratio motor high precision mini transmission long life high power weight ratio multi channel slip ring high reliability measures severe mechanical electrical thermal conditions functional test mechanical tests vibration acceleration shock etc thermal vacuum cycling test electromagnetic compatibility test demonstrated excellent functionality design development test processes summarized paper
background published randomized controlled trial rct showed difference knee placebo patients osteoarthritis wanted assess impact trial clinical practice united states purpose hypothesis evaluate changes knee practice publication article assess effect rct behavior practicing orthopaedic surgeons hypothesized publication trial overall frequency knee decrease mean age patients undergoing knee decrease proportion diagnosis decrease study design descriptive epidemiology study methods state ambulatory surgery database used analyze cases classified tear tear changes age surgery rates case classification evaluated trial using student tests analysis variance results publication trial number knee per year increased mean patient age increased years tears increased representing approximately additional cases per year decreased representing approximately fewer cases per year tear increased representing approximately additional cases per year conclusion overall age rates knee increased contrary hypothesis identified decrease rates knee publication trial demonstrating rcts influence patterns clinical practice
house solution verification dose delivered moving phantom required clinical implementation lung body radiation therapy developed superior inferior movement required simulate tumour motion normal breathing cycle achieved via novel use arduino low cost open source microcontroller board connected high torque servo motor slow imaging used acquire image set cone beam verified efficacy margins treatment moving phantom treatment fields delivered section phantom dose verification dynamic phantom film using gamma analysis acceptance criteria registered absolute dose pass rate respectively verified received prescribed dose per fraction using dynamic phantom major discrepancy planned measured results due interplay sequences target motion observed study confirmed use house solution using open source hardware software existing quality assurance equipment appropriate validating new treatment technique
autism spectrum disorder asd associated reduced social stimuli eyes results inconsistent known whether play role putative altered social asd show visual trials children asd slower eyes among controls matched age sex nonverbal however another condition brief spatially sound presented just visual targets group effect reversed results indicate social versus stimuli differently modulated mechanisms young children asd autism authors autism research published wiley periodicals inc behalf international society autism research
rapid development mobile data acquisition technology volume available spatial data growing increasingly fast pace real time processing big spatial data become research field geographic information systems gis cope highly dynamic data aim reduce time complexity data updating modifying traditional spatial index however existing algorithms data structures based single work nodes handling required high numbers update rates moving objects paper present distributed spatial index based apache storm open source distributed real time computation system using approach compare range nearest neighbor query efficiency four spatial indexes single dataset introduce method performing spatial two moving datasets particular build secondary distributed index spatial join queries based grid partition index finally series experiments presented explore factors affect performance distributed index demonstrate feasibility proposed distributed index based storm real world application approach integrated information system provides real time traffic decision support
chinas rapid urbanization generated substantial attention throughout world various studies assess chinas urbanization process without consistent conclusions paper attempts evaluate chinas urbanization level based global urban development experience urbanization theories addition adopts plots method assess chinas regional urbanization level results study show chinas urbanization rate normal level consistent curve growth theory migration theory theory normal growth also chinas economic development stage however certain problems challenges remain examined low level coordination chinas urbanization employment narrow difference urbanization rate level general eastern provinces show high coordination urbanization economic development whereas provinces low coordination low urbanization rate economic development levels located central western china results advance previous literature also deserve particular attention chinese policymakers local governments pay close attention urbanization quality urban planning support systems industry structure focusing much urbanization quantity american society civil engineers
background purpose increasing evidence suggests presence demyelination normal appearing white matter patients spectrum disorder objective determine presence subclinical demyelination patients using myelin water imaging methods whole brain regions interest analyses including corpus optic radiation conducted patients healthy controls hcs using two modalities conventional direct visualization short transverse relaxation time component results conventional myelin water fractions global three corpus slightly lower patients hcs although statistically significant hand values global except corpus significantly lower patients relative hcs particular optic radiation significantly reduced patients relative hcs methods even patients brain involvement additionally patients optic showed lower patients without optic negative correlation identified optic radiation visual functional system score conclusions study identified presence widespread demyelination patients highlighted optic radiation site marked demyelination
study reports outcomes follow low cost intervention randomized control trial hospital treated self poisoning intervention months plus usual treatment versus usual treatment three binary endpoints months suicidal ideation suicide attempt self cutting significant reduction suicidal ideation suicide attempt non western population however effect self cutting sustained brief contact reduce forms suicidal behavior self poisoning patients post intervention phase
micrornas mirnas reported critical players among numerous cancer related mirnas expression level mir potential role investigated showed overexpression mir identified specimens cells compared normal bone tissues high level mir correlated high classification advanced clinical stages patients notably mir highly expressing patients showed notably reduced survival rate vitro experiments showed loss mir inhibited cell proliferation cell cycle progression induced apoptosis turn restoration facilitated cell growth suppressed apoptosis experimental mice showed mir silencing vivo growth cells furthermore bioinformatics software predicted box repeat containing protein direct target mir observed negative regulation mir expression direct binding verified dual luciferase assays cells forced expression resulted reduced proliferation cell cycle arrest phase increased apoptosis mir overexpressing cells summary study demonstrates mir probably functions driver tumor progression targeting highlights potential effects mir prognosis treatment published elsevier
tnf alpha stimulated gene kda protein generated activated macrophages modulates inflammation however mechanism action role activation macrophages fully understood observed markedly augmented lps induced inflammatory lung injury mortality mice compared mice treatment mice prevented lps induced lung injury neutrophil increased survival mice found inhibited association thereby suppressing kappa activation also prevented expression proinflammatory proteins inos tnf alpha beta increasing expression anti inflammatory proteins macrophages shift associated suppressed activation proinflammatory transcription factors addition observed lps regulated expression mice suggesting role macrophages thus functions converting macrophages proinflammatory anti inflammatory phenotype secondary suppression kappa signaling activation
fatal brain hemorrhage april provides excellent platform study potential causes one famous headaches history differential diagnosis headache including hypertension melanoma discussed health problems context serious diseases leaders tangible effect upon historical interpretation large body evidence presented support probable cover health problems doctors close necessity challenging conventional thinking health leaders fundamental importance understanding health issues also emphasized
objective long term prognosis hepatocellular carcinoma hcc remains poor owing lack treatment options advanced hcc cytokine induced killer cells vivo expanded lymphocytes expressing cell markers cell therapy alone insufficient treating advanced hcc thus study aimed determine whether treatment cells combined acid provide synergistic effect inhibit tumor growth mouse model hcc methods upregulation natural killer group ligands retinoic acid early inducible mouse major histocompatibility complex class polypeptide related sequence human evaluated concentrations reduce tumor volume calculated avoid cytotoxicity mouse model hcc cells generated mouse using interferon gamma monoclonal antibody interleukin potential synergistic effect cells combined evaluated mouse model tissue pathology investigated results incubation expression increased hcc cell lines compared control fold fold fold fold maximal vivo dosage showed significant cytotoxicity compared control day cells generated mouse treatment cells plus synergistic effect observed relative tumor volume mouse model hcc relative tumor volume untreated control mice increased combination treatment group increased conclusions induced increase ligands expression significantly enhanced effects cell therapy mouse model hcc
algae complex photosynthetic systems absorbed solar energy forms energy production food metabolites addition promising used field white biotechnology enhancing sustainable production food metabolites green energy sources review made uncover significance various metabolites like free fatty acids compounds compounds etc etc apart importance metabolites antibiotics anticancer antiviral anti inflammatory agent also discussed metabolites obtained algae several biotechnological industrial pharmaceutical cosmetic uses also discussed review along emerging technology harvesting enhancing production compounds like etc commercial level later sections discussed genetically modified organisms metabolite production also briefly discussed concept highlighting functioning companies engaged metabolites production cost effectiveness challenges addressed companies
micrornas mirnas short similar nucleotide length rnas perform gene regulation recently mirna shown linked onset cancer diseases based mirna expression levels important therefore understand mirna function disease onset however order fully understand mirnas role disease necessary detect expression levels small molecules widely used mirna detection method northern blotting considered standard mirna detection methods method however time consuming low sensitivity led increase amount detection methods available detection methods either solid phase occurring solid support solution phase occurring solution solid phase methods adaptable high throughput screening possess higher sensitivity northern blotting lack ability vivo use often time consuming solution phase methods advantageous performed vivo sensitive rapid however applied high throughput settings although multiple detection methods available including microarray technology based assays electrochemical assays etc still much work done regarding mirna detection current gaps mirna detection include ability perform multiplex sensitive detection mirna single nucleotide specificity along standardization new methods current mirna detection methods gaps methods mirna therapeutic options future outlook mirna detection presented
aims hypothesis adiponectin important regulation insulin sensitivity man receptors recently identified expression adipose tissue regulation response insulin diabetic patients never assessed therefore explored regulation adiponectin expression adipose tissue skeletal muscle adiponectin plasma concentrations response insulin methods patients type diabetes studied double blind placebo controlled crossover study using vivo techniques measuring adipose tissue muscle blood flow combined measurement adipose tissue skeletal muscle gene expression results treatment increased adiponectin concentrations skeletal muscle expression regulated median interquartile range relative units adipose tissue expression regulated relative units contrast expression expression altered either tissues increase adipose tissue expression associated increased triglyceride clearance increased fasting fatty acid output measured subcutaneous adipose tissue conclusion expression regulated adipose tissue regulated skeletal muscle data suggest plays role mediating effects adiponectin specific tissues relation insulin
aim study optimize production pure lactic acid employing cost effective production medium based designed biomass approach found exhibit high optical purity cost effective medium constituted using palm protein carbon nitrogen sources respectively design indicated significant variables influence production central composite design response surface methodology used optimize concentrations maximum predicted respectively fermentation experimental results exhibited maximum productivity highest ever reported production renewable batch process present investigation potential application economically viable raw enhanced production attributed fold reduction production cost compared conventional medium international union biochemistry molecular biology inc
pathogenesis alzheimers disease involves multiple pathways include decreased proliferation plus increased loss affecting neurons astrocytes subcellular level involve several elements amyloid amyloid precursor protein protein response ubiquitin proteasome system wnt catenin system notch signaling system mitochondria calcium tau data presented show intimate anatomical interactions neurons astrocytes interactions several subcellular factors affecting cells treatments currently available correct dysfunctions subcellular factors available treatments include lithium since subcellular pathogenesis involves multiple interacting elements combination treatment effective administration single drug directed element overall purpose presentation describe pathogenesis detail explain proposed treatments
surface metal provide new opportunity converting solar energy chemical energy article outline mechanisms surface catalytic organic based recent studies efficient conversion solar chemical energy achieved way replacing heat based catalysis conventional chemical manufacturing solar energy providing guidance designing catalytic materials
objective examine effect selenium supplementation cell counts viral suppression time antiretroviral therapy art initiation art naive hiv infected patients methods multicenter double blinded placebo controlled randomized clinical trial conducted eligible patients hiv infected adults years cell count cells art eligibility cells throughout trial willing practice barrier methods birth control patients randomized receive daily selenium tablets identical placebo followed months assessments every months declines cell counts modeled using linear regressions generalized estimating equations effect modification composite outcome art eligible art initiation using cox proportional hazards regression conducted intention treat results participants received selenium women median age years rate depletion reduced confidence interval decrease treatment arm mean cells per month mean cells per month observed composite outcome events treatment arm found treatment effect composite outcome hazard ratio viral suppression odds ratio trial powered composite outcome due lower anticipated event rate adverse events comparable throughout conclusions randomized clinical trial demonstrated month selenium supplementation significantly reduces rate cell count decline among art naive patients copyright wolters kluwer health inc rights reserved
recently combination therapy involving inhibitor neuroprotective agents shown better desirable effect management prevention dementia limited information available effect dietary hence study sought assess combined pretreatment effect major compound inhibitor cognitive function induced memory impairment rats rats pretreated via oral administration seven successive days dementia induced end treatment period single injection via intraperitoneal administration thereafter changes spatial episodic memory conducted estimation biochemical parameters associated cognitive function determined treated rats showed impaired learning memory increased activities acetylcholinesterase adenosine lipid peroxidation concomitant decreased levels nitric oxide reduced glutathione gsh superoxide dismutase sod catalase activities compared control however combination improves learning memory activity associated inhibitory effect activities compared control addition combined pretreatment significantly decreased lipid peroxidation increased levels antioxidant status compared treated rats finding supports concept combination strategy alternative therapy management prevention neurological disorders thus observed anti effect linked inhibitory effect key enzyme cholinergic system associated memory function
background examined association cardiovascular health younger ages proportion life lived free morbidity cumulative burden morbidity average healthcare costs older ages methods study heart association detection project industry longitudinal cohort employed men women years age baseline examination baseline measurements included blood pressure cholesterol diabetes mellitus body mass index smoking individuals classified cardiovascular health favorable levels factors factors high elevated risk factors high risk factor high risk factors linked medicare national death index data used determine morbidity older age individuals cause morbidity score cardiovascular morbidity score calculated international classification disease ninth revision codes year follow results included participants became years age representing original participants female white mean age years baseline favorable levels factors risk factors elevated levels high risk factor high risk factors favorable cardiovascular health younger ages extended survival almost years onset cause cardiovascular morbidity years respectively resulting compression morbidity absolute relative terms translated lower cumulative annual healthcare costs favorable cardiovascular health medicare eligibility conclusions individuals favorable cardiovascular health early middle age live longer healthier life free types morbidity findings provide strong support prevention efforts earlier life aimed preserving cardiovascular health reducing burden disease older ages
several approaches proposed relational databases using criterion avoid disclosure sensitive information identification attacks relational database said meet criterion record identical least records terms quasi identifier attribute values database satisfy constraint item successively considered quasi identifier attribute process greatly increases dimensionality thus also computational complexity information loss paper novel efficient system called proposed data small information loss also reduce computational complexity process system consists three modules pre processing module module model data guarantees least achieved pre processing module traveling problem module module extensive experiments carried compare efficiency designed approach state art algorithms terms scalability runtime information loss results indicate proposed system outperforms compared algorithms
chapter considers effect ratio lateral deformation longitudinal waves bars consequent density change non adopted herein dimensionless velocity longitudinal wave constant ratio based non incorporation density correction lateral inertia using strength materials approach gives dimensionless velocity decreases increases ratio tensile compressive loads respectively conditions take place considering density correction considering lateral inertia considering corrections analogy extended case plane waves density correction required thereafter revisit lateral inertia love provides combined effect density youngs modulus ratio polar radius wave number velocity longitudinal waves love
high level unwanted pregnancies among young women urgent public health problem south africa study sought establish awareness utilisation attitude towards use emergency contraception among patients seen commercial city reproductive health clinic south africa cross sectional descriptive study conducted means self administered questionnaire among sexually active females ages years two thirds participants heard among used among heard heard clinics two thirds participants knew correct timing taken following sexual intercourse majority indicated used prevent unplanned pregnancy majority participants displayed positive attitude towards use third participants reported cultural beliefs majority also indicated recommend women family planning method awareness utilisation good among participants women displayed positive attitudes towards perceived beneficial health professionals inform alert women clients consequences unprotected sex guide make informed choices means adequate information regarding
background observational studies osteoporotic fractures patients type diabetes indicate increased incidence compared without diabetes results inconsistent currently type diabetes considered independent risk factor low energy fractures subjects aim study assess association type diabetes risk hip vertebral fractures postmenopausal women materials methods searched medline web science cochrane databases articles published september studies assessing fractures women aged diagnosed type diabetes regardless diabetes treatment deemed eligible estimate fracture risk meta analysis random effect model performed results shown odds ratio confidence interval heterogeneity tested using cochrane test significance analyzed measure results total observational studies cohort cross sectional controls included thirteen papers provided information incidence hip fractures seven vertebral ones meta analysis revealed type diabetes associated higher risk hip fracture vertebral fracture significant heterogeneity hip fracture studies american origin identified potential source heterogeneity conclusions results meta analysis indicate increased risk hip fracture postmenopausal women type diabetes
original documents presented elucidate origin physical organic chemistry late early field gained fast popularity within four decades created presently accepted mechanistic model organic chemistry focus research organic chemistry shifted synthesis around physical organic chemistry lost visibility though mechanistic investigations became integral aspects synthetic method development important physical organic chemistry chemistry mechanistic enzymology continued develop separate systematic use newly developed techniques gas phase chemistry laser spectroscopy matrix isolation expected lead classical physical organic chemistry
scene text information extraction plays important role many computer vision applications features existing text extraction algorithms applicable one text extraction stage text detection recognition significantly consistency end end system especially complex chinese texts tackle challenging problem propose novel text structure feature based text structure component detector layer residual network chinese texts inspired three layer chinese text cognition model human combine layer residual network extract features suitable text extraction stages specialized modeling chinese characters layer simulates key structure component cognition layer psychological model residual mechanism residual network simulates key bidirectional connection among layers psychological model organic combination layer residual network extracted features applicable text detection recognition humans evaluation text detection recognition models based proposed text structure feature achieve great improvements baseline cnn models end end chinese text information extraction system experimentally designed evaluated showing advantage proposed feature unified feature
dementia global health problem huge impact lives several distinct diseases classified term dementia ranging neurodegenerative disorders alzheimers disease chronic infections central nervous system rare complication virus infection childhood clinical features neuropsychological profiles imaging characteristics various dementia syndromes sufficiently distinct distinguish one another however cases cognitive psychiatric behavioural features sufficiently overlap testing help recognized eeg special role play diagnosis certain illnesses disease characteristic eeg changes current research potential utility quantitative eeg one tool clinicians dealing patients suffer illness searched pubmed cochrane database january january combining search terms eeg electroencephalography dementia status identified papers searches read detail summarized discuss qualitative quantitative eeg findings various types dementia
purpose purposes paper investigate schedule performance new green building projects identify critical factors influence schedule performance new green building projects provide solutions improve schedule performance new green building projects design methodology approach questionnaire survey conducted responses received firms experienced green building projects singapore data survey analyzed face face interviews conducted two senior project managers comments survey results findings study identified degree project delay new green building projects green building projects singapore result indicated percent green building projects delay projects significantly higher likelihood delay significantly longer extension new projects addition cooperation solve problems influential schedule performance new green building projects two project groups agreed overall ranking factors affecting schedule performance research limitations implications geographical limitation conclusions drawn findings also sample size still small despite relatively high response rate addition majority respondents contractors project players respond survey practical implications study provides clear understanding schedule performance green building projects critical factors highlighted constructing green building projects also strategies overcome negative impact factors allow practitioners better deal potential causes delay attain schedule performance originality value although construction delays widely investigated previous studies relating construction management attempted analyze schedule performance new green buildings thus study adds significantly existing research green building construction delay
aim less worlds described plant species assessed red list leaving many species conservation prioritization large scale red list assessment plant species challenge species ranges resolved coarse scale geographic distribution key assessment criterion red list evaluate use coarse scale distribution data predictive models assess global scale drivers extinction risk economically important plant group location global methods using coarse scale species distribution data train machine learning model biological environmental variables species assessed red list order identify correlates extinction risk predict extinction risk species best models map predictions identify potential threat results model achieved classification accuracy threatened species non threatened species accurately predicted model predicted presently evaluated criteria threatened human impacts key correlate threat spatial analysis identified threat yet red list example central main conclusions first time machine learning model used determine extinction risk global scale species rich plant group coarse scale distribution data exist many plant groups methods replicated provide extinction risk predictions across plant kingdom approach used low cost prioritization tool targeting field based assessments
paper deals approach modelling view control networks described strongly coupled multi sources multi loads systems nonlinear known characteristics model representative system behaviour easy handle easy regulators synthesis first step modelled linearized around operating point subdivided two lower order systems according singular perturbation theory regulators designed subsystem tested means software test bench allows predicting network behaviour steady transient states finally designed controllers implanted experimental benchmark constituted two supplying loads order test dynamic performances realistic conditions published elsevier ltd rights reserved
soluble catalyze hydrolysis corresponding one property number enzymes catalyze hydrolysis substrates one enzyme fashion used dispersion corrected density functional theory method investigate conversion oxide large cluster model active site consisting atoms designed basis ray crystal structure complex competitive inhibitor different substrate orientations two examined full reaction mechanisms opening two calculated including hydrolysis half reactions calculated overall reaction energy profiles show rate determining step associated dissociation covalent intermediate second step hydrolysis half reaction calculations reproduce experimentally observed two substrate calculated yield product obtained energy profiles indicate transition states hydrolysis half reactions taken account order understand outcome reaction transition state structures analyzed detail several factors contribute selectivity control identified addition mechanistic scenario active site residue form also considered implications energies discussed current calculations demonstrate applicability quantum chemical cluster methodology reproducing experimental support usefulness tool asymmetric results presented helpful rational engineering obtain variants refined properties
oil crisis environment pollution problem become increasingly prominent gaseous fuel internal combustion engines gas engines valued great resources potential feature low pollution gaseous fuel however average efficiency just large amount energy exhaust cooling water therefore effective way improving efficiency recover waste heat steam rankine cycle organic rankine cycle considered quite suitable methods waste heat recovery especially large engines system specific large gas engine advantages disadvantages gas engine rated power studied object paper according characters waste heat systems different working fluids including two stage organic rankine cycle built math model compared aspects recovered power thermal efficiency system feasibility provides reference engineering application finally economic performance evaluated compared elsevier ltd rights reserved
without active therapy patients myelofibrosis provide update phase study plus patients median follow years forty patients enrolled study patients response response treatment using response criteria published quality response improved time overall response rate response splenomegaly seen patients anemia response median time treatment failure patients months median duration response months response highly durable patients six patients months years three patients still treatment beyond months years complete partial responses seen one five patients respectively achieving deeper response necessary response durable new clinical studies needed explore safe tolerated based combination strategies patients elsevier ltd rights reserved
turning point life many men men lacked father figure growing birth child catalyst fresh start researchers called qualitative investigations african american fathers parenting beliefs practices consider social contexts within broader research discourse investigations inform way frame african american fathers research thereby improving theoretical suggestions better supporting black men roles present case study details experiences young african american man participating larger based intervention program focused strengthening father child relationships among african american families findings highlight story serves positive prevailing negative stereotype african american men parents thematic coding analysis revealed several major themes current article focuses decisions transform experience growing without father dedicated resolve remain actively present sons life process author refers intergenerational change finally case study helps mitigate dearth positive research african american fathers challenging deficit based research narratives
areas agreement noted terms need thoroughly scientifically document boundary conditions violent video games impact players however argued contrast violent media generally violent video games specifically increase likelihood aggressive behavior desensitization violence linked increases aggressive attitudes beliefs also argued research findings demonstrating violent video game effects considered terms known impacts types media human thoughts behavior documented psychological processes empirically demonstrated underlie acquisition types social behavior just aggression end evidence provided types media shown clearly impact human psychology psychological mechanisms potentially underlie media violence effects discussed noted clearly evident reasons violent video games impact thoughts behavior less media subject different psychological processes research evidence considered contexts concluded mentioned impacts violent media exposure human thought behavior including violent digital games demonstrated two levels proof balance probabilities beyond reasonable
article deals ability fractional modeling describe bounded diffusion behavior encountered modern thin film nanoparticles lithium battery electrodes indeed diffusion impedance batteries behaves half order integrator characterized impedance high frequencies becomes classical integrator described capacitor low frequencies transition two behaviors depends particles geometry three considered paper planar cylindrical spherical ones fractional representation proposed gray box model able perfectly fit low high frequency impedance behaviors optimizing frequency response transition identification results provided using simulation data considering three electrochemical diffusion models based particles geometry furthermore knowing geometry allows estimate diffusion ionic resistance time constant using relationships linking physical parameters structural fractional model parameters finally simulations using impedance models including charge transfer impedance external resistance demonstrate interest fractional modeling order identify properly charge transfer impedance also diffusion physical parameters particles geometry elsevier rights reserved
discrete fluid power systems featuring transmission lines inherently include pressure oscillations experimental verification discrete fluid power power take system wave energy converters shown cylinder pressure force shifts performed article investigates cylinder pressure oscillations reduced shaping valve opening trajectory without need closed loop pressure feedback furthermore energy costs reducing pressure oscillations investigated
advent recommendation color space ultra high definition television development mapping algorithm wide standard greatly needed wide production particularly assumption simultaneous live high definition television broadcast scenarios real time mapping vital designing algorithm requires careful consideration shape size significantly different paper set requirements mapping propose preserved mapping algorithm mapping paths designed color space modifications prediction based subjective experimental results constant perceived prevent excessive reduction colors changed design process mathematical expressions proposed mapping algorithm provided addition demonstrate improvements image quality
objective recent studies suggested autoimmune diseases immune activation play part pathogenesis different neurodevelopmental disorders study investigated association personal history family history autoimmune disease risk developing attention deficit hyperactivity disorder adhd method cohort formed born denmark resulting study population individuals followed information autoimmune diseases obtained danish national hospital register individuals adhd identified danish national hospital register danish psychiatric central register results total children diagnosed adhd study period autoimmune disease individual associated increased risk adhd incidence rate ratio primary analyses associated maternal autoimmune disease adhd offspring incidence rate ratio whereas paternal history autoimmune diseases significantly associated adhd offspring exploratory analyses increased risk adhd observed children family history type diabetes autoimmune hepatitis psoriasis ankylosing spondylitis conclusion personal history maternal history autoimmune disease associated increased risk adhd previously reported association type diabetes adhd confirmed addition specific parental autoimmune diseases associated adhd offspring
last decades geotextiles progressively incorporated geotechnical applications especially field coastal engineering geotextile materials often act filter layer laid versatile material gradually substituted traditional granular materials ease installation consistent quality labour cost efficiency however geotextiles often suffer damage installation due high dynamic bulk loading rock placement degrade geotextiles mechanical strength properties considered paper include impact resistance retained strength geotextiles general greater impact energy applied geotextiles greater potential damage results highlight using index derived values indicator determine geotextile performance site test results shows geotextiles fibre continuous better mechanical properties outperform lower mechanical strength materials product index value shows inferior impact resistance compared product least strength given impact energy test results also indicated reduction strength materials much greater compared materials subjected impact energy elsevier ltd rights reserved
present continuous variable quantum key distribution scheme based quantum coherent states yields raw secret key made discrete variables protocol preserves efficient detection schemes current technology single photon detection techniques time efficient error correction privacy amplification schemes due binary modulation key show certain type attack secure almost value optical line used share two mode states loss limitation characteristic beam splitting attacks present protocol works needed efficient direct techniques reverse order generate secure key beyond loss case attack level
paper explores perceptions regarding family paid employment expressed university students based analysis quantitative data region southern argue increasing labor markets role paid employment historically individuals particularly mens life project altering expectations work family life likewise changes gender roles shaped family life seems case especially women strongly economic independence personal projects traditional family views conclude young people demanding new balance life understood mainly personal family time work also strong individual project including demand greater gender equality although still level projected future findings signal changes way relation work family traditionally organized bringing new challenges public policy
vaccination saved lives medical procedure pathogens now evolved vaccination using empirical paradigms vaccine design strategies based mechanistic understanding pertinent immunology required eliminate perspective describe just examples work aimed achieve goal bringing together approaches statistical physics biology clinical research
objective lipid mediators implicated pathogenesis allergic rhinitis pharmacological studies indicate two classes receptors exist high affinity receptor lower affinity antagonist currently used treat asthma allergic rhinitis binds equal affinity also called previously described receptor recently emerged potential novel receptor purpose study determine expression localization protein human nasal mucosa methods human obtained patients nasal obstruction refractory medical therapy protein expression evaluated western blotting specific cells expressing protein identified immunostaining using commercial anti monoclonal antibody results kda band detected western human nasal samples using anti monoclonal antibody find differences protein levels allergic non allergic nasal mucosa immunohistochemical studies revealed monoclonal antibody mainly labeled vascular smooth muscle cells nasal mucosa conclusion immunohistochemical results suggest play roles vascular response functional studies necessary clarify biological significance receptor nasal vasculature elsevier ireland ltd rights reserved
aim present study evaluate effects sperm motility different times cleavage formation embryo quality ability experiment sex sorted chromosome bearing incubated factors namely caffeine caffeine untreated control experiment using short standard length comparing two different media namely synthetic fluid medium medium cleavage formation rates significantly higher group respectively compared control group respectively cleavage rates formation significantly lower shortest time medium respectively medium time resulted highest cleavage rates formation respectively medium produced highest embryo quality grade rate motility affect rates whereas affected length extended compared conclude adding motility sex sorted albumin lactate pyruvate sperm improve cleavage embryo development rates without increasing addition shortening sperm time resulted similar overall embryo performance rates compared prolonged interval
research examined affective cognitive responses culture fusion specific type culture mixing features blending different cultures parts thereof new entity influenced individual differences need closure two studies showed individuals high low felt less favorable toward culture fusion affective response abstract level society structure models study concrete level food stimuli study addition high individuals tended assign culturally fused stimuli one discrete culture rather culturally hybrid cognitive response furthermore mediation analyses showed relationships responses toward culture fusion mediated right wing findings interpreted terms threat security needs posed culture fusion
worldwide economic impact dementia estimated billion without discovery cure effective interventions delay disease progression annual global economic impact expected early alzheimers disease leading cause dementia accounting cases toxic accumulation amyloid beta beta either clearance failure thought underlying mechanism neuronal cell death characteristic though amyloid hypothesis increasingly challenged recent years compelling alternative hypothesis points chronic neuroinflammation common root late life degenerative diseases including apolipoprotein apoe genotype strongest genetic risk factor apoe epsilon proinflammatory individuals genotype accumulate beta high risk developing almost half patients one epsilon allele recent studies suggest bidirectional relationship exists sleep pathology sleep play important role beta clearance getting good quality sleep poor quality sleep reduce risk associated neuroinflammation epsilon allele taken together findings particularly important given sleep disruptions commonly associated increased burden disrupted sleep poses caregivers current review aims identify individuals high risk dementia benefit sleep interventions explore role poor sleep quality plays type dementia examine science sleep interventions date provide road map pursuit comprehensive sleep interventions specifically targeted promote cognitive function delay progression dementia
experimental study conducted single cylinder forced air cooled hydrogen spark ignition generator set converted gasoline generator set rated power rpm study carried various compression ratios base spark degrees top dead centre exhaust gas recirculation volume furthermore experimental tests conducted engine varied start gas injection various compression ratios order find limiting start injection results indicated engine operation higher compression ratio improved brake thermal efficiency reduced occurrence residual gas fraction decreased increased compression ratio however nox emission increased increased compression ratio order reduce nox emission source level engine operated spark different percentage relative nox emission decreased spark time degrees maximum brake torque whereas decreased volume delay gas injection reduce chance occurrence decreased increased compression ratio notable point emerged study hydrogen spark ignition engine spark time suitable strategy nox emission reduction whereas optimum level better strategy reduce nox emission compared base hydrogen engine without copyright hydrogen energy publications llc published elsevier ltd rights reserved
trend towards electrical drivers rather mechanical drivers offshore installation led implementation large electrical systems power generation due offshore environment constraints weight footprint limitations installation remains operated voltage lower leads specific constraints electrical network design paper provides overview implementation current limiting devices design stage operation case study also developed based fault event occurred floating production storage leading severe damage consequences operation conditions current limiting devices operated correctly fault occurred damage production losses due causes highlighted
composite data sets measured different objects usually affected random errors also influenced systematic genuine differences objects experimental conditions individual measurements forming data set quantitative approximately normally distributed correlation coefficient often used compare data sets however relations data sets obvious matrix pairwise correlations since numerical value correlation coefficient lowered random systematic differences data sets work presents multidimensional scaling analysis pairwise correlation coefficients places data sets unit sphere within low dimensional space position given values defined science radial direction systematic differences one angular directions dimensionality reduction used classification purposes also derive data set relations continuous scale arrangement data sets onto subspace systematic differences surface unit sphere allows irrespective random error levels identification clusters closely related data sets method gains power increasing numbers data sets illustrated example low signal noise ratio image processing application shown approach completely general thus widely applicable
latino americans rapidly growing ethnic group united states studies population limited evaluated characteristics patients surveillance epidemiology end results program national cancer institute data draws population lower incidence present slightly younger non latino whites present older age latino sub populations higher incidence giant cell non latino whites incidence similar despite lower rates radiation therapy greater rates sub total resection non latino whites better year survival rates record chemotherapy data latino sub populations similar age extent resection use radiation therapy associated improved survival none variables sufficient multivariate analysis explain improved survival relative non latino whites molecular data available records studied status patients database methylation mutation rates statistically significantly different non latino whites patients available information chemotherapy radiation rates similar non latino white latino patients latter lower rates gross total resection present younger age
paper reports investigation effect fabric substrates coating materials electrical mechanical performance printed antennas coupled antennas printed fabrics using silver assure protection printing structure configured consisting surface coating conductive printing protective coating order simulate realistic situation three fabric substrates single selected woven fabrics everyday wear three coating materials chosen conventional conformal coating materials printed circuit boards experimental results verified fabric substrates selected fit specific end use application since shown antenna performance significantly affected coating suggested support antenna performance since gave least impairment fabrics mechanical performance
dynamic data structures software applications shown large impact system performance paper explore energy saving opportunities interface based dynamic data structures results suggest savings opportunities exist collection propose prototype architecture creating adaptive green data structures applying machine learning tools build model predicting energy efficient data structures based dynamic workload neural network model classify energy efficient data structures based features number elements frequency operations interface set bag semantics fold cross validation result show average accuracy predictions gram model accurately predict energy efficient data structure sequence simulated real world programs average accuracy using predictor prototype demonstrates green data structure implemented simple decision making technique data structure efficiently adapt energy efficiency low overhead actual potential energy savings two test computers range elsevier inc rights reserved
proper handling samples analyzed mass spectrometry guarantee excellent results greater depth analysis working quantitative proteomics critical trying assess non traditional sources ear saliva aqueous tears fluid breast milk cervical vaginal fluid nasal alveolar lavage fluid provide relevant aspects quantitative proteomics recognize recent clinical research work conducted atypical samples analyzed quantitative proteomics reference recent different approaches used non traditional sources allows compare new strategies development novel experimental models hand references help contribute significantly understanding proportions proteins different clinical interest lead potential advances emerging field precision medicine
background injection beta amyloid beta mice allows investigation acute effects cognitive function cellular pathology aim investigation characterize time course beta induced cognitive behavioural changes detect potential molecular mechanisms methods implanted lateral cerebral ventricle days surgery mice injected beta phosphate buffered saline starting days injection evaluated cognitive behavioural performance using modified hole board test determined tumour necrosis factor alpha tnf alpha caspase western blotting days data analysed using general linear modelling mann whitney test results beta induced decline cognitive performance represented increased total number wrong choices testing period day behavioural parameters comparable mice treated beta difference regarding tnf alpha levels groups compared day caspase levels increased day conclusions application beta lateral ventricle mice associated cognitive impairment declarative memory interference caused altered behaviour therefore represents valid model acute beta mediated effects although exact mechanisms remain unclear changes levels caspase suggest apoptosis important factor development cognitive dysfunction elsevier rights
antibacterial resistance increasing globally recognized major public health threat antibacterial coordinated effort improve appropriate use antibiotics aim decrease selective pressure multidrug resistant organisms order preserve utility antibacterial agents article describes activities antibacterial resistance leadership group area antibacterial date focused development rapid diagnostic tests coupled educational institutional initiatives enable robust needed address current crisis antibacterial resistance addition exploring effectiveness techniques community hospitals also developed strategy trials assess feasibility reducing antibacterial usage preserving patient outcome
work presents project teaching innovation subject technology manufacturing developed last five years objective stimulate students training self evaluation system based learning tools agreement guidelines european higher education area system includes methodology perform series evaluations theoretical practical knowledge allows student self learning data obtained proposed system analyzed effect student results discussed evolution time student grades involvement satisfaction project influence final score presented
influence early life experience degree parental infant attachment emotional development children adolescents comprehensively studied structural mechanistic insight biological foundation maintenance mammalian defensive systems metabolic immune nervous behavioral slowly advancing emerging field developmental molecular genetics initial evidence revealed differential early life generates stable differences offspring hypothalamic pituitary adrenal hpa regulation part chromatin remodeling changes dna methylation specific genes expressed brain revealing physical biochemical molecular paths epidemiological concept gene environment interactions herein primary molecular mechanism underpinning early developmental programming lifelong maintenance defensive emotional responses offspring alteration chromatin domains specific genomic regions state accessible state conversely dna methylation promotes formation essential gene silencing genomic integrity chromosome segregation therefore inter individual differences chromatin modifications dna methylation marks hold great potential assessing impact early life experience effectiveness intervention programs guided psychosocial strategies focused changing behavior pharmacological treatments target chromatin remodeling dna methylation enzymes dietary approaches alter cellular pools metabolic intermediates methyl donors affect nutrient bioavailability metabolism review article discuss potential molecular mechanism gene regulation associated chromatin modeling programming endocrine hpa metabolic cardiovascular behavioral vigilance responses stress including alterations dna methylation role dna repair machinery parental history drugs housing illness nutrition socialization maternal offspring exchanges nutrition microbiota antibodies stimulation nature provides mechanistic insight experiences propagate external internal variables also identifies composite therapeutic target chromatin modeling gestational prenatal stress adolescent anxiety depression adult onset neuropsychiatric disease
latest developments database technologies becomes easier store medical records hospital patients first day admission previously possible intensive care units icu modern medical information systems record patient events relational databases every second knowledge mining huge volumes medical data beneficial caregivers patients given set electronic patient records system effectively disease labels facilitate medical database management also benefit researchers paper proposed framework achieve goal medical chart note data patient used extract distinctive features encode patient features apply bag words encoding method chart note data also propose model takes account global information local correlations diseases correlated diseases characterized graph structure embedded sparsity based framework algorithm captures disease relevance labeling disease codes rather making individual decision respect specific disease time global optimal values guaranteed proposed convex objective function extensive experiments conducted real world large scale icu database evaluation results demonstrate method improves multi label classification results successfully incorporating disease correlations
humanized antibody bone forming agent development treatment osteoporosis examine effects bone quality mature monkeys treated months post vehicle months months followed vehicle months serum bone formation markers increased first months corresponding increased bone formation biopsies months dual energy ray absorptiometry dxa bone mineral density bmd increased lumbar spine proximal femur month corresponding significant increases bone strength lumbar vertebral bodies cores femur neck bone mass remained positively correlated strength sites changes calculated material properties cortical sites bone quality measures also maintained group despite gradual loss bone mass normal bone mineralization confirmed ash analyses radial transient reversible reduction cortical bmd observed month despite relative improvements bone mineral content high resolution confirmed decline cortical bmd radial second set administered months radial strength maintained strength improved estimated finite element modeling decreased radial cortical bmd consequence increased remodeling increase cortical porosity resulted marked improvements bone mass architecture bone strength maintaining bone quality supporting bone efficacy safety profile american society bone mineral research
paper describes teaching strategies lean project construction management training course organized civil engineering program university school science engineering intention scholars practitioners explains training course objectives content principles tools techniques practices lean construction philosophy among others also includes incorporation management system tools techniques complement paper also describes lectures workshops simulations made feedback obtained students collaborative work routines among others success training course reflected opportunities improvement identified editing publishing made possible feedback collected participants authors published elsevier ltd
ability identify patients respond specific therapies number disease areas particularly oncology anticipated also case cell based therapies particularly complex heterogeneous diseases rheumatoid arthritis recently clinical results expanded adipose derived mesenchymal stem cells indicated clinical efficacy highly refractory patients study set determine circulating micrornas mirnas identified potential biomarkers associated response patients mirna expression profiles pre treatment plasma samples patients determined using microarrays ten mirnas identified differentially expressed group compared group confirm differential expression mirna biomarkers assayed quantitative reverse transcriptase polymerase chain reaction qrt pcr analysis three mirnas mir mir mir confirmed statistically significantly upregulated group compared group receiver operating characteristic analysis confirmed diagnostic potential mirnas represent novel candidate stratification biomarkers associated patient response clinical validation
crops represent important component southern biodiversity potential contribute regions post development discourse reviewed potential crops respect contribute topical challenges food nutrition security human health climate change adaptation environment employment creation poor rural communities fact crops product generations agriculture supports idea resilient adapted needs farmers marginal agricultural environments addition crops also seen offering economic advantages due uniqueness suitability environments grown low input requirements certain cases crops associated specific gender roles women seen particularly significant production evidence also suggests inclusion crops cropping systems contributes dietary diversity improved nutrition context post agenda potential crops generate income address food security status subset biodiversity links number sustainable development goals addressing social economic environmental issues
egfr gamma signaling mediates high glucose induced beta akt activation collagen upregulation cells renal first published july doi glomerular matrix accumulation hallmark diabetic nephropathy recently shown epidermal growth factor receptor egfr mediates high glucose induced collagen upregulation beta akt signaling cells phospholipase gamma gamma interacts activated growth factor receptors activates classic isoforms thus studied role induced collagen upregulation primary rat treated osmotic control protein kinase activation assessed western blotting collagen upregulation northern blotting diabetes induced rats streptozotocin treatment led gamma membrane translocation phosphorylation indicative activation without effect gamma phosphorylation also seen cortex diabetic rats induced physical association egfr gamma identified precipitation gamma activation required egfr kinase activity since prevented egfr inhibitor overexpression kinase inactive egfr kinase inhibition also prevented gamma activation induced akt phosphorylation beta inhibited gamma inhibitor gamma inhibition downregulation small interference rna also prevented induced collagen upregulation results indicate egfr gamma signaling mediates induced beta akt activation subsequent collagen upregulation inhibition egfr gamma provide attractive therapeutic targets treatment diabetic nephropathy
background purpose thick corpus associated outcome fetuses clinical presentation older children seems markedly different methods corpus defined thick based observations impressions reviewed cases children diagnosed based brain magnetic resonance imaging mri studies pertinent clinical data children collected measured results brain mri images children initially considered showing initial imaging reviewed experienced confirmed diagnosis children epilepsy capillary syndrome autistic spectrum disorder increased head circumference specific neurologic disorder defined seven children measured thickness children comparable published literature adults conclusions rare brain found apparently diverse mechanisms necessarily associated life threatening conditions instead relatively benign finding different nature reported fetuses
objective synthesize descriptions findings mcp wrist joints different types arthritis normal state high resolution peripheral quantitative computed tomography assemble literature reporting ability detect findings relative imaging modalities results reproducibility image interpretation methods systematic literature review performed using terms mcp wrist joints using medical literature databases conference abstracts study describing predefined pathology findings comparison another radiographic technique measure reproducibility included limitation disease state results identified studies meeting inclusion criteria articles identified search reported pathology findings including bone bone mineral density variables joint space evaluation characterization seventeen studies compared findings either plain radiography ultrasound magnetic resonance imaging tomography high sensitivity erosion detection twenty four studies included assessment reproducibility good excellent metrics highlighting critical importance positioning assessing joint space variables conclusion despite high sensitivity erosion detection good reproducibility research required determine applied enhance understanding bone changes variety arthritis conditions
objective assess frequency characteristics findings usefulness clinical test sensory integration balance evaluation balance patients psoriatic arthritis psa comparing test computerized dynamic study design series consecutive patients fulfilled criteria psa matched controls studied setting study performed division tertiary reference center intervention evaluation including followed performed patients age sex frequency matched controls main outcome measure patterns gold standard assessed compared patients sixty psa patients women matched controls results psa patients higher frequency abnormal response abnormal caloric test controls cases respectively benign paroxysmal diagnosed two patients none controls significantly increased frequency abnormal test loss pattern patients compared controls observed significantly increased frequency abnormal also observed psa patients versus controls yielded sensitivity specificity positive predictive value negative predictive value conclusions study indicates findings common psa useful assessing balance disorder screening routine clinical practice patients
tau critical role alzheimers disease frontotemporal dementia neuronal function eventually leading neurodegeneration critical role tau supported studies transgenic mouse models express tau mutation found cases familial frontotemporal dementia accumulation tau hippocampus causing reductions hippocampal long term impairments spatial learning memory however remained unexplored role tau reducing neuronal excitability show two complementary tau transgenic mouse models tau induces threshold action potential initiation reduces firing hippocampal neurons rescued suppression transgenic tau furthermore using mutagenesis primary hippocampal neuronal cultures reveal reduction neuronal excitability results initial segment tau phosphorylation dependent manner also demonstrate effect microtubule dependent addition pharmacological stabilization found prevent structural functional deficits caused tau finally demonstrate neurons tau transgenic mice correlates reduction excitability therefore propose reduction hippocampal excitability due tau mediated distal contributes hippocampal dysfunction observed
engine performance varies significantly due variations weather conditions different regions order optimize performance fuel consumption engines calibrated according weather conditions operate paper effects air conditions pressure temperature power fuel consumption engine modeled first comprehensive one dimensional model real engine constructed power validated experimental data actual engine next using model set experiments carried varying pressure temperature humidity incoming air engine speed measuring outputs power engine two mathematical models developed using neural networks also regression technique estimate outputs terms inputs last estimation ability models shown set new experiments models used engine calibration shift process near blind one one prior information significant role
several studies recently demonstrated volumes specific brain regions reduced children adolescents post traumatic stress disorder ptsd compared healthy controls study investigated potential association early traumatic experiences altered brain regions functions conducted systematic review scientific literature regarding functional magnetic resonance imaging meta analysis structural magnetic resonance imaging studies investigated cerebral region volumes pediatric patients ptsd searched articles psycinfo pubmed medline web knowledge databases data regarding amygdala hippocampus corpus brain intracranial volumes fit inclusion criteria extracted combined meta analysis assessed differences groups meta analysis found reduced total corpus areas reduced total cerebral intracranial volumes patients ptsd total hippocampus left right hippocampus gray matter volumes amygdala frontal lobe also reduced differences significant functional studies revealed differences brain region activation response stimuli post traumatic stress symptoms ptsd group results confirmed pediatric patients ptsd exhibited structural functional brain abnormalities abnormalities occurred different brain regions observed adults
aim research paper determine incidence risk factors clinical outcome solid organ transplant recipients diagnosed treated institution analysis patients diagnosed treated infection occurring january december patients diagnosed infection recipients renal transplant accounted cases annual incidence infection significantly now greater prevalent renal transplant recipients expected biochemical factors associated include lower glucose cerebrospinal fluid csf analysis median csf white blood cell median csf protein median serum antigen titers higher cohort median clinically headache admission odds ratio prolonged length stay median cohort significant infection recipients remains rare however marked increase cases since study reveals need increased vigilance potential emerging infectious disease furthermore highlights need ongoing research aid early diagnosis management screening cost effectiveness
low level radio frequency control system linear accelerator national laboratories new digital radio frequency controller controller critical keep phase amplitude frequency stability field resonator linear accelerator work superconducting condition resonance frequency low beta mhz medium high beta mhz controller control time eight different signals sampled signals fed field programmable gate array fpga implements control loop signals processed fpga phase modulated sent power amplifiers hence main feature new control system digital control loop direct sampling antenna signal phase components obtained suitable choice frequency control field phase cavity based digital complex phase modulator paper presents fpga acquisition techniques performances new controller
image given measurable data projections important task reconstruct find image provides measured data problems frequently used theory applications image processing paper algorithms investigated triangular grids reconstruction binary images using three six direction projections algorithm generates initial population using network flow algorithm two input projections reconstructed images evolve towards optimal solution close optimal solution using crossover operators guided mutation operators quality images improved using switching components operator elsevier rights reserved
acid plant responds favorably organic matter recently united states grown additional nitrogen fertilizer applied compensate immobilized decomposition field trial established oct usa evaluate alternative partial full replacement within certified organic system treatments alone depth debris covered geotextile treatments applied comprised one component factorial trial included two cultivars two bed configurations raised flat two fertilizer sources fish emulsion meal two fertilizer rates low high organic replaced four growing seasons average cumulative yields first years fruit production plant plant plant treatment highest cumulative yield regardless either low high rate meal years soil soil remained optimum range treatment soil depth higher leaf nutrient concentrations including treatments overall study demonstrated application debris provided large benefit soil maintenance increased soil test effect years tissue nutrient concentrations leaves
adolescents type diabetes increased risk glycemic control poor quality life depressive symptoms stress coping related outcomes adolescents diabetes yet studies examined constructs longitudinally study aimed describe stress coping adolescents type diabetes examine coping strategies predictors adolescent adjustment depressive symptoms quality life glycemic control adolescents type diabetes completed measures diabetes related stress coping symptoms depression quality life baseline months months data glycemic control collected adolescents medical charts adolescents use primary control coping problem solving secondary control engagement coping positive thinking strategies predicted significantly fewer problems quality life fewer depressive symptoms time contrast use coping strategies avoidance predicted problems quality life depressive symptoms coping significant predictor glycemic control coping mediated effects diabetes related stress depressive symptoms quality life ways adolescents type diabetes cope diabetes related stress predict quality life symptoms depression glycemic control use screening identify adolescents diabetes related stress targeted interventions improve coping strategies potential improve outcomes
objective evaluate patients characteristics associated clinical decision request mri hla patients spa daily practice methods patients referred rheumatology outpatient clinic national referral centre selected patients clinical diagnosis spa according included mri hla available patients ordered tests characteristics associated ordering mri hla identified analyses variables completeness selected analysis multi variable logistic regression analysis used evaluate determinants related decision perform mri hla odds ratios confidence intervals calculated results total patients spa included cohort men mean age disease duration years patients mri hla tests ordered independently predictive factors ordering mri presence enthesitis number initial symptoms presentation per additional symptom present independently predictive factors hla testing number initial symptoms per symptom conclusion study strongly suggests use certain clinical clues decide order expensive scarce tests diagnostic work spa patients manifestations increase efficiency tests clinical practice suggest clinical reasoning follows principles bayesian theory
two dimensional model developed thermal stresses elastic strains creep strains creep energy density interfaces short long assemblies plane stress plane strain conditions linear viscous non linear creep constitutive behavior static cyclic thermal loading modeled layers interfacial stresses strains approximated using combination exact elasticity solutions elementary strength materials theories partial differential equations linearized simple finite difference discretization procedure approach mathematically straightforward extended include plastic behavior problems involving external loads variety geometries model provide input data thermal fatigue life prediction adhesive joints typical joint demonstrated predicted cyclic stress strain hysteresis shows rapid stabilization creep energy dissipation per cycle agreement predictions finite element analysis elsevier ltd rights reserved
purpose study investigate influence personal beliefs previous contact health issues level empathy medical students scale empathy student version personal beliefs university religion index applied brazilian medical students findings suggest meaning life previous mental health treatment positively related empathy suggest attention given prevention treatment mental health issues studies needed understand replicate findings
background concept mental toughness gained increasing importance among groups elite athletes virtue psychological importance explanatory power broad range health related behaviors however study focused far psychological origins therefore aims present study explore extent psychological profiles preschoolers aged five associated scores sleep disturbances age explore possible gender differences method nine years first assessment age five preschoolers total adolescents mean age years females took part follow study baseline parents teachers completed strengths difficulties questionnaire covering internalizing externalizing problems hyperactivity negative peer relationships prosocial behavior participants completed questionnaires covering socio demographic data sleep disturbances results higher prosocial behavior lower negative peer relationships lower internalizing externalizing problems age five rated parents teachers associated self reported higher lower sleep disturbances age age relative males females lower scores reported sleep disturbances conclusion pattern results suggests traits adolescence origins pre school years
study examined three potential moderators relations maternal parenting stress preschoolers adjustment problems genetic short allele serotonin transporter allele gene physiological baseline respiratory sinus arrhythmia behavioral reports childrens negative total mothers age years reported parenting stress preschoolers age years boys negative internalizing externalizing sleep problems results indicated genetic sensitivity variable according differential susceptibility model however results involving physiological behavioral sensitivity factors consistent stress framework implications prevention intervention efforts counter effects parenting stress discussed
paper presents harmonic instability analysis method using state space modeling participation analysis inverter fed power systems full order state space model controlled distributed generation inverter built first including time delay digital control system inner current voltage control loops outer based power control loop based inverter model overall state space model two inverter fed system established eigenvalue based stability analysis presented assess influence controller parameters harmonic instability power system moreover harmonic frequency oscillation modes identified participation analysis presented evaluate contributions different states modes reveal system gives rise harmonic instability based participation analysis reduced order model harmonic instability analysis also proposed experimental results presented validating theoretical analyses
background emergency responders frequently injuries providing medical fire law enforcement services national surveillance systems provide fragmented perspectives injuries specific classes workers government volunteers report selected injuries employment information incomplete methods characterized injuries among emergency medical services fire police using data national electronic injury surveillance system occupational supplement work injuries treated hospital emergency departments results sprains strains leading injury among police police career highest injury rates injuries per full time equivalent workers respectively conclusions physical demands emergency response area leading cause injuries benefit similar interventions across assess risk improved exposure data need acquired particularly volunteers med published wiley liss inc
research present preoperative robotic surgery simulator platform means training surgical system simulator employs phantom now touch master device control arms simulated model virtual environment earlier simulators built primarily work based linux operating systems first attempt towards development simulator matlab cross platform application allows accessibility simulator broader community surgeons researchers simulator designed provide feedback user results realistic surgery environment key features include opening closing surgical tool using feature surgeon motion surgical robot adjust position input device per requirement simulator successfully built tested matlab results simulation satisfactorily verified efficacy proposed system
recent years draw technology attracted eyes non rendering paper generation method image chinese effect based edge detection provided implemented programming matlab platform using method platform given color image picture chinese effect automatically user even background experimental results proved methods effective satisfied use simple easy operate learn
voltage scaling fundamental technique energy efficient computing field recent studies tackling topic show degraded system reliability frequency scales address conflict subject reliability aware power management extensively explored still investigation heterogeneous computing systems hcs provide high performance potential researchers consider systems unfortunately existing scheduling algorithms constrained tasks shared hcs adequately consider reliability conservation study design joint optimization schemes energy efficiency system reliability directed graph adopting shared recovery technique achieve high system reliability noticeable energy preservation best knowledge first time address problem hcs extensive comparative evaluation studies randomly generated real world applications graphs show scheduling algorithms compelling terms enhancement system reliability energy saving elsevier ltd rights reserved
petroleum oil utilized low cost value added operations design scale oil demands reliable data intrinsic reaction rates currently missing literature intrinsic rates reactions determined canadian oil fluid four different specific surface area measurement techniques used normalize specific reaction rate calculated weight loss profiles tga bet surface area two micro porosity measurement techniques based density functional theory dft models finally active surface area measured different levels conversion conversion specific reaction rates calculated different levels conversion divided different surface areas order find specific surface area results best reduction variability reaction rate using surface area variable overall found best deriving intrinsic rates surface areas based bet technique also proven better choice specific rates compared ones based dft models
background hypogonadism common patients renal dysfunction always correct following transplantation recent studies show increased mortality dialysis transplant patients low testosterone patients often treated due concerns efficacy complications real surprisingly scant literature supporting use therapy patients examine results therapy patients renal failure following transplant methods identified men mens health registry treated either dialysis functioning transplant time therapy demographic laboratory clinical outcome data collected electronic medical record results men dialysis functioning transplant mean age years range years mean total serum range symptoms including fatigue erectile dysfunction mean therapy included patches topical mean follow months range months mean post therapy range mean improved patients improved range cardiovascular infectious complications conclusions symptomatic hypogonadism common dialysis transplant patients replacement therapy safely given improvement values symptoms patients anemia usually improved used transplant recipients without infectious complications
many proteins especially proteins communicate regulatory states active sites structural deformations functionally important understand deformations dynamical experiments ideal challenging using static structural information although limited dynamical analysis much accessible protein analysis strain natural quantity studying local deformations calculate strain tensor fields proteins deformed ligands thermal fluctuations using crystal nmr structure strains primarily show deformations around binding sites deformations induced solely ligand binding distant sites reveal quasi paths mechanical coupling active sites constitute widespread mechanism argue strain particularly shear appropriate quantity analysis local protein deformations analysis reveal mechanical biological properties many proteins
control essential prevent cattle discomfort economic losses however increased resistance lead producers adopt strategies result accumulation chemical residues meat milk possibilities poisoning animals people scenario demonstrates necessity research identification novel effective environmentally safe therapeutic options cattle control objectives study develop assess efficacy control artificially eighteen male month old divided three groups six animals group animals receive medication control group group animals received dilution orally administered twice daily group received single application formulation median efficacy respectively however upon analyzing reproductive efficiency noteworthy efficiency superior action days treatment study provided information effects ovaries females showed deposition results suggest inhibition larvae interference reproduction future possibilities eco friendly control
objective rapid development economic construction requires modern major engineering implement management model increase operation efficiency major engineering works also lower risk engineering works raise management ability engineering team methods thesis optimize coordinated management considering structure major projects build model results article establishes management model information dimension phase dimension linkage dimension beneficial enrich theoretical major construction management provide maximum guarantee success construction conclusion testing management major project thesis comes management theories major projects
improvements overall sustainability include reductions energy consumption remain significant yet largely opportunities reduce energy consumption commercial buildings investments required green certification help systematically improve sustainability design buildings percentage buildings green increases sustainability overall building sector improved order facilitate diffusion green commercial buildings important understand patterns diffusion key factors influencing buildings decisions applying spatial fraction model instrumental variable approach data commercial buildings new york florida paper demonstrates strong spatial correlation diffusion green building also finds split incentive problem building owners plays role diffusion findings important implications policy makers analyzing interactions green buildings characteristics green building clusters results useful identification buildings likely adopt green
study aimed evaluate total phenolic contents storage vitro digestive system simulation culture degrees stored degrees days fermentation storage total phenolic contents quantified high performance liquid chromatography respectively cell viability lactic acid bacteria yeast evaluated fermentation promoted increase approximately log cfu cycles microorganisms storage process alter total phenolic contents content increased fold total phenolic content increased fold therefore good source since content substances increased significantly vitro digestive system simulation product elsevier ltd rights reserved
objectives examine extent agreement nursing home residents reports pain presence intensity derived interview questionnaire minimum data set mds nearest interview date design cross sectional comparison data sources pain measurements setting nursing homes included evaluation projects program senior health options participants nursing home residents grouped based type answering interview questionnaire resident family proxy staff proxy measurements used kappa statistics multinomial regression examine agreement interview questionnaire mds pain presence intensity results presence pain reported times often questionnaire depending group agreement presence pain slight fair kappa mds questionnaire slight agreement pain intensity kappa family proxy group showed largest discrepancy questionnaire mds reporting pain presence intensity staff proxy group better agreement pain intensity groups achieved slight agreement kappa conclusions detecting quantifying pain nursing home residents complex pain information best obtained directly residents observations standardized mds revised accordingly
purpose purposes determine contraceptive methods pregnant adolescents use postpartum understand factors predispose intention use less effective birth control long acting reversible contraception methods participants pregnant minority adolescents prenatal program intention assessed asking following methods preventing pregnancy use deliver multinomial logistic regression analysis used determine factors associated intent use contraception male female condoms abstinence withdrawal method short medium acting hormonal contraception birth control pill patch vaginal ring acetate compared implant intrauterine device postpartum results twenty three percent intended use method method participants intended use contraceptive methods significantly likely believe effective preventing pregnancy report make decisions help reach goals partners important making contraceptive decisions important factors mother aged years first birth high school experienced prior pregnancy parents birth control options perception limited financial resources conclusions distinct profiles factors associated use contraceptive methods postpartum identified inform future interventions promote use prevent repeat pregnancy society adolescent health medicine rights reserved
serious water pollution problem many lakes reservoirs one method understanding causes strategies address phenomenon watershed modeling integrated model developed paper simulating evaluating water quality protection strategies reservoirs based controlling upstream point non point sources pollution also reservoir operation achieve soil water assessment tool model used modeling surface runoff transportation pollutant load watershed area numerical model used simulating reservoir water quality models linked simulate transmission distribution water quality variables watershed reservoir system west part iran calibration models different strategies reduction pollution watershed simulated ranked based efficiency reducing pollution load entering reservoir results show completion sewage network wastewater treatment plant city long adopting measures direct release municipal wastewater river reduce pollution load best short term strategy also found long term period watershed management decreasing local animal activities effective measure reducing nutrient load entering reservoir thus need considered future watershed management policies programs
cancer related deaths due development systemic metastatic disease clearly much remains understood biological principles govern human cancer metastasis aiming objective decrease metastasis related mortality patients many years research metastasis conducted great part experimental mouse models mainly difficulties sampling longitudinal studies molecular human metastatic disease however recently extraordinary advances microfluidic technologies allowing isolation characterization human circulating tumor cells primary tumor mass process distant metastasis analysis human now revealed important features cancer metastasis high metastatic potential clusters compared single dynamic expression epithelial mesenchymal markers treatment possibility culture patients real time individualized testing drug susceptibility nevertheless several aspects biology remain characterization stem like cell population among human focus describing latest findings field discuss context cancer stem cell biology defining molecular features metastasis initiating stem like holds exceptional promise develop metastasis tailored therapies patients cancer
paper effect gas including bubble flows enhancing shear force process flat sheet module investigated experimentally image processing numerically using software order study characteristics bubble flows flat sheet module analyzed video system facilitated high speed camera experimental results show average diameter flow much larger bubble flow flux bubble flows increased respectively compared case gas numerical results shown good agreement measurements qualitatively quantitatively results simulations also demonstrate although flow patterns increase shear stress increasing velocity gradient shear stress induced flow considerably larger therefore flow higher induced shear stress effective enhancement flux process elsevier ltd rights reserved
internal structure asphalt mixture revealed ray computed tomography images provides useful information variety civil engineering applications paper studied two image processing issues commonly encountered asphalt ray images image intensity caused beam effect image segmentation inspired illumination correction techniques morphological method proposed solve image intensity two modified multilevel methods developed effectively divide asphalt images three aggregates comparisons existing multilevel methods ones developed study indicate proposed methods provide consistent robust accurate results moreover developed objective functions enable user easily adjust thresholds match visual examination laboratory test results modifying single parameter developed methods help improve analysis asphalt images various engineering applications american society civil engineers
structural integrity multi component structures usually determined strength durability adhesive bonding often chosen welding due reduction stress concentrations reduced weight penalty easy manufacturing amongst issues past decades finite element method fem used simulation strength prediction bonded structures strength materials fracture mechanics based criteria cohesive zone models already proved effective tool modelling damage growth limitations aforementioned techniques despite fact still suffer restriction damage growth predefined growth paths extended finite element method recent improvement fem developed allow growth within bulk solids along arbitrary path degrees freedom special displacement functions thus overcoming main restriction two techniques tested simulate bonded single double joints comparative evaluation two methods showed capabilities limitations specific purpose elsevier ltd rights reserved
animal studies led significant advances understanding pain mechanisms intestine lead altered signaling disorders irritable bowel syndrome however translate human afferent nervous system unclear recent studies demonstrated possible use variety techniques including electrophysiological recordings begin examine concepts humans mini review examines studies explore animal studies translate humans suffering irritable bowel syndrome highlights advantages technical limitations approaches identifies priorities future studies using human tissues
ring russia considered famous route russia since now acts famous brand also pattern tourism development parts country ring sites still keep high tourism recreational attractiveness domestic flows declining last decade route subjected significant changes lead functional spatial transformation article discusses various factors cause changes research methodology based combination systems approach geographical statistical studies spatial construction management research results show original circle route now replaced number radial single point routes former multi day converted short even single day time new tourism new along new forms tourism activities emerge region addition traditional russian historical innovative tourism clusters appear now different parts ring area time parts former ring route integrated new regional tourism products transformation together changes consumers interests demand notably diversified types tourism ring russia route aimed mainly cultural tourism now leisure family business event types tourism developing necessary differentiate regional tourism working distinct tourism specialization distinguish local tourism programs
background blockade lymphocytes fusion protein effective treatment immune mediated disease relapsing remitting multiple sclerosis objective evaluate efficacy safety methods cooperative clinical study multiple sclerosis phase randomized double blind placebo controlled multi center trial planned participants randomized monthly intravenous placebo weeks ratio switched opposite treatment weeks received final dose study medication weeks enrollment closed early due slow primary endpoint mean number new enhancing lesions obtained magnetic resonance imaging mri scans performed every weeks results statistically significant differences observed mean number new mri lesions placebo groups statistically significant differences observed mri clinical parameters disease activity tolerated conclusion study demonstrate efficacy reducing number new mri lesions clinical measures disease activity
agricultural led use high inputs chemical rice cultivated nitrogen heavy metals runoff loss land major environmental problem important mitigate nitrogen heavy metal pollution water body nitrogen heavy metal transformation rice field surface water studied applied combined organic inorganic nitrogen fertilizer plus inhibitor phosphate sandy soil blue soil results showed application rice field organic inorganic fertilizer combined application models decreased heavy metal average concentration total surface water respectively furthermore sandy soil blue soil nitrate nitrite total inorganic nitrogen concentrations decreased rice field surface water addition organic inorganic fertilizer combined application models rice field respectively used effective inhibitor decline potential nitrogen heavy metals runoff loss combined application models organic inorganic rice fields minimizing nitrogen heavy metal transformation risk agricultural fields water body beneficial protecting ecological environment
background chronic antigen exposure ageing increases frequency box expressed cells bet expressing lymphocytes mice frequency significance cell bet expression chronic hepatitis hcv infection human subjects never described methods healthy controls hcv infected patients non hcv patients cirrhosis recruited peripheral blood mononuclear cells expression bet related markers flow cytometry subset patients underwent antiviral therapy cured hcv infection sustained virological response dynamics bet expression cells monitored cure cells tested bet expression exposure infected plasma recombinant hcv proteins results forty nine patients including healthy donors hepatitis infected individuals nine liver cancer cirrhosis eight without cirrhosis eight patients cirrhosis due non hcv related cause recruited found cells patients chronic hcv exhibited increased frequency bet cells relative individuals median significant differences cancer bearing infected individuals bet cells expressed higher levels compared bet cells predominantly exhibit tissue like memory phenotype independent hcv infection bet cells hcv infected patients frequently class switched igg resolution hcv infection direct acting antiviral therapy leads marked reduction frequency bet cells median pretreatment end treatment exposure cured cells plasma recombinant hcv protein led expression bet conclusion chronic chronic hcv infection induces maintains antigen specific bet cell cells share markers tissue like memory cells antigen driven bet expression critical suppressor cell activation chronic hcv infection
functional outcome schizophrenia heterogeneous markers course missing functional outcome associated social cognition negative symptoms gesture performance nonverbal social perception critically impaired schizophrenia tested whether gesture performance nonverbal social perception predict functional outcome ability adequately perform relevant skills everyday function functional capacity months naturalistic longitudinal study patients schizophrenia completed tests nonverbal communication baseline follow addition functional outcome social occupational functioning functional capacity follow assessed gesture performance nonverbal social perception baseline predicted negative symptoms functional outcome functional capacity month follow gesture performance predicted functional outcome beyond baseline measure functioning patients gesture deficits baseline stable negative symptoms experienced decline social functioning patients without gesture deficits negative symptom severity decreased social functioning remained stable thus simple test hand gesture performance baseline indicate favorable outcomes short term follow results support importance nonverbal communication skills subjects schizophrenia
mediated memory impairment concern based therapies caffeine receptor induced memory deficits adenosine receptor mediated mechanism now evaluated chronic acute blockade adenosine receptors affects long term episodic memory deficits induced single injection selective agonist long term episodic memory assessed novel object recognition test mice received intraperitoneal injection receptor agonist immediately training tested novelty recognition later anxiety levels assessed elevated plus maze test immediately mice also tested exploratory behaviour open field chronic blockade day administered orally days acute blockade assessed injection administered either together min test phase involvement assessed using antagonist caused disruption action absent mice also receiving encoding consolidation phase ineffective present retrieval effects detected elevated plus maze open field test finding mediated memory disruption prevented adenosine highlights possibility prevent cognitive side effects therapeutic application drugs desired elsevier ltd rights reserved
background majority parkinsons disease cases sporadic idiopathic suggesting neurodegenerative disorder result environmental genetic factors stress neuroinflammation among factors investigated possible contributions experiments rodents showed severe chronic stress reduce number dopaminergic neurons substantia nigra cells lost actions least part mediated increased oxidative stress tested hypothesis interleukin receptor alpha cytokine receptor whose activation increases vulnerability dopaminergic neurons oxidative damage participates stress dependent damage neurons methods mice subject daily sessions acute stress weeks days week procedure previously showed induce loss dopaminergic neurons source kinetics interleukin endogenous ligand evaluated weeks stress identification producing cell type performed situ hybridization experiments markers oxidative stress microglia activation number dopaminergic neurons knock animals wild type evaluated weeks stress weeks following week period compared non stressed mice results expressed microglial cells within fraction tyrosine hydroxylase positive neurons levels elevated daily stress peaked weeks chronic restraint stress significantly reduced number dopaminergic neurons mice neuronal loss weeks significantly lower mice however loss dopaminergic neurons measured weeks weeks non stress following weeks stress similar mice conclusions cytokine previously demonstrated increase susceptibility dopaminergic neurons oxidative stress elevated restraint stress lack prevent delayed neuronal loss mouse model chronic restraint stress represent target reduce rate neuronal loss occur severe chronic restraint stress
differential gene expression three pairs populations clones susceptible resistant investigated differential display representation differential expression genbank searches genes selected showed four sequences corresponded different hypothetical proteins others similar genes encoding dehydrogenase transporter ribosomal protein sequence analysis performed clones obtained approximately half clones encoded different hypothetical proteins half encoded proteins involved stress response antioxidant defence metabolism transporter proteins surface proteins ribosomal proteins others mrna levels eight genes obtained analysed northern blotting confirm differential expression sequences six eight genes iron superoxide dismutase heat shock protein transferase mrna levels drug resistant population least twice susceptible population analysis showed although levels mrna four fold higher resistant population corresponding increase observed levels protein expression results suggest directly associated drug resistance phenotype elsevier rights reserved
background mobility changes concerning elderly patients cognitive decline given older individuals vulnerability injury critical identify contributors limited mobility objective examine whether structural brain abnormalities including reduced gray matter volume white matter associated limited mobility among individuals cognitive impairment determine whether cognitive impairment mediate relationship methods thirty four elderly individuals mild cognitive impairment mci alzheimers disease underwent neuropsychological evaluation mobility assessment structural brain neuroimaging linear regression conducted predictors including gray matter volume six regions interest roi white matter burden mobility measures outcomes results lower gray matter volume nucleus associated slower speed functional mobility task higher cerebellar volume also associated slower functional mobility white matter burden significantly associated mobility conclusion findings provide evidence associations subcortical gray matter volume speed functional mobility task among cognitively impaired individuals
lungs constantly exposed external environment addition particles also contains pathogens allergens toxins order maintain tolerance induce immune response immune system appropriately handle inhaled antigens lung dendritic cells dcs essential maintaining delicate balance initiate immunity required without causing damage lungs due inflammatory response detailed understanding phenotype function immune cells dcs human blood knowledge cells less accessible tissues lungs much limited since studies human lung tissue samples especially healthy individuals scarce work presents strategy generate detailed spatial phenotypic characterization lung tissue resident dcs healthy humans undergo sampling biopsies several small biopsies collected individual subsequently embedded digested advanced flow cytometric analysis outlined protocols optimized yield maximum information small tissue samples steady state conditions contain low frequency dcs present work focuses dcs methods described directly expanded include immune cells interest found mucosal lung tissue furthermore protocols also directly applicable samples obtained patients suffering pulmonary diseases part establishing diagnosis chronic obstructive pulmonary disease copd lung cancer
absence markers inflammation cerebrospinal fluid csf commonly predicts absence simplex virus central nervous system cns infection consequently multiple authors proposed validated criteria pcr testing csf hosts normal csf white blood cell protein levels cells years old hiv organ transplant adoption criteria exclude infected persons necessary diagnostic test alternatively reduce costs associated tests minimal effect patient care little known cost effectiveness approach decision analysis model developed evaluate adoption criteria screening tests csf estimates input parameter values combined available literature review two largest health care systems united states adoption criteria screen test need proved cost effective less patients testing truly cns infection similar prior studies none cases adoption criteria united states save estimated million million million annually model calculations remained robust variation test cost prevalence infection random variation study assumptions adoption criteria screen pcr tests csf represents cost effective approach
paper proposes new cmos based voltage reference generator circuit using resistors cmos technology reference generator uses three stage operational amplifier improved performance previously proposed circuits proposed design simulated simulator circuit produces output reference voltage room temperature degrees supply voltage analysis shows low temperature coefficient degrees obtained output reference voltage temperature range degrees degrees using poly silicon resistor area reduced without losing much control current consumption
background salivary cortisol measurement non invasive method suitable use neonatal research mother infant separation birth represents stress skin skin contact numerous benefits aim study measure salivary cortisol mothers newborns order assess effect mothers infants stress estimate efficacy collecting small saliva samples newborns methods salivary cortisol measured mother infant pairs first fifth small saliva samples using high sensitivity quantitative elisa kit nmol low cortisol levels detection samples collected eye minutes results cortisol level mothers decreased highest levels measured lowest differences values significant first fifth first cortisol level decrease detected increase newborns fifth decrease detected increase newborns without confirmed significance difference saliva sampling efficacy using eye conclusions cortisol level decrease mothers proves stress reduction variable cortisol levels infants indicate stress reduction imply need research used sampling method appeared one optimal considering sample volume sampling time efficacy
high performance applications filter added auxiliary resonant inverter reduce output current ripple however resonance occurs due additional filter makes traditional closed loop control suitable used directly therefore paper presents double loop digital control based active damping method capacitor current feedback stabilize system studies active damping methods focused grid consideration zero resistance however load resistance neglected drive system therefore load resistance digital control delays considered paper moreover improved loading method proposed improve duty ratio range order verify effectiveness controller prototype developed simulation experimental results demonstrate soft switching realized entire load range maximum duty ratio improved using proposed loading method resonance eliminated using proposed control method
objective investigate effect exposure virtual reality environment preoperatively patient reported outcomes surgical operations background scarcity developed quality improvement initiatives targeting patient satisfaction methods performed randomized controlled trial patients undergoing cranial spinal operations tertiary referral center patients underwent randomization preoperative experience standard preoperative experience stratified type operation primary outcome measures evaluation score preoperative anxiety information score markers patients experience surgical encounter results study period total patients mean age years females underwent randomization average score standard deviation standard preoperative experience difference confidence interval exposure experience also led higher score difference addition led lower preoperative vas stress score difference higher preoperative vas difference vas satisfaction difference scores association identified vas stress score difference conclusions randomized controlled trial demonstrated patients exposed preoperative increased satisfaction surgical encounter harnessing power technology hospitals create environment minimizes stress enhances perioperative experience
background objectivethe cytokine interleukin relatively new discovery however powerful stimulating tumor necrosis factor alpha tnf inflammatory conditions objective research explore fluctuations levels tnf saliva fluid focus measurements taken clinical treatment chronic periodontitis material purposes study total patients chronic periodontitis controls healthy recruited important clinical periodontal criteria established start research chronic periodontitis group given initial form periodontal care samples saliva fluid collected exactly preceding following care levels tnf present saliva fluid recorded via use elisa baseline levels tnf fluid saliva significantly higher among patients chronic periodontitis group among patients control group hand baseline levels significantly lower fluid saliva chronic periodontitis group control group significantly positive link found tnf levels two study groups treatment levels tnf saliva fluid significantly lower chronic periodontitis group compared baseline readings however levels significantly higher level present saliva fluid useful indicator condition expectations treatment care according results research proinflammatory impact potentially linked intensity progression periodontitis
background definitive diagnostic criteria follow strategies long syndrome children borderline long interval methods results retrospectively evaluated clinical course genetic testing results corrected interval score school aged children years old points genetic testing results positive patients high intermediate low probabilities respectively maximum mean follow significantly differed among categories probability minimum however rest recovery point exercise stress testing dramatically changed last consequently probability changed half patients conclusions score reasonable indicator evaluating school aged children patients low score appear low risk cardiac events however score change follow therefore concern patients preferable continue following guidelines follow strategies desired
authors propose generalised multi layer architecture phase network hybrid analogue digital provides flexible trade offs performance implementation complexity changing layer number authors adjust complexity achievable performance two stage algorithm adopted analogue digital matrices designed separately analogue adaptive second order channel statistics simple iterative algorithm proposed upper bound average rate effective channel analogue digital adaptive effective channel interference cancellation ideal phase discrete phase limited phase amplitude resolutions considered algorithm design theoretical analysis simulation used demonstrate good performance flexibility proposed technique antenna system use radio frequency chains perform closely full digital fully connected achieve performance simple also robust limited phase resolution enables select proper performance implementation complexity according requirement capability real systems
glycine max sought oil protein components genetic approaches add value either component ongoing efforts breeding molecular biology programmes former primary vegetable oil consumed world hence primary usage direct human consumption means increase utility feed applications thereby expanding market investigated simultaneous displacement marine ingredients based protein high omega fatty acid oil enriched alpha acids communicated herein formulations major reduction marine ingredients translates total omega fatty acids harvested building findings subsequent efforts directed towards genetic strategy translate prototype design optimal identity preserved based aquaculture whereby stack approach targeted synthesis two value added output traits acid introduced crop end systematic introduction seven transgenic molecular phenotypic evaluation derived novel events described
past decade mechanical characterization data nanoparticle reinforced polymer matrix composites shown significant improvements compressive strength shear strength comparison baseline properties synergistic reinforcing influence nanoparticle reinforcement obvious simple rule mixtures approach fails quantify dramatic increase mechanical properties consequently immediate need investigate understand mechanisms nanoscale responsible unprecedented strength enhancements multi scale multi physics simulation approach considered computationally viable since relying single time length scale require huge amounts computational resources potentially lead inaccurate results proof concept case study involving crack initiation graphene presented together methodology computing integral based estimates continuum fields methodology used gain better understanding influence nanoscale phenomena continuum scale mechanical properties polymer nanocomposite current research contribute towards understanding advanced nanostructured composite materials within context integrated computational materials engineering
virtual reality surgical training planning require creation virtual models patient anatomy medical scans mri real time head tracking applications allows users virtual anatomy position orientation process rendering highly detailed volumetric data anatomical models dynamically changing observers perspective extremely demanding computational resources propose parallel computing solution problem involving distributed volume graphics rendering system composed multiple nodes concurrently working different frames output stream later integrated form final animation scenario important consider frame losses generated order output sequence images paper presents study frame losses distributed graphics rendering system consisting multiple gpu based heterogeneous nodes running best effort rendering scheme applying alternate frame rendering technique describe mathematical model frame losses performance evaluation comparing model predictions experimental results elsevier ltd rights reserved
pseudomonas aeruginosa induced rapidly progressive ocular infectious disease often leads inflammatory epithelial edema stromal infiltration tissue destruction corneal vision loss study investigate role motif regulating inflammatory process induced expression increased mouse vitro cultured macrophages infection knockdown expression significantly inhibited activation kappa signaling decreased production proinflammatory cytokines vivo vitro infected furthermore investigated potential mechanism found infection promote linked poly transforming growth factor beta activated kinase leading activation enhanced inflammatory responses taken together demonstrated proinflammatory effect induced suggest potential therapeutic target
derive essential polyunsaturated fatty acids play crucial roles immunity development reproduction however potential links dietary supply biosynthesis poorly understood especially using bacterial parasite model system studied expression genes coding key enzymes biosynthesis genes related response dietary acid acid parasite exposed non exposed animals gene expression related cyclooxygenase activity especially responsive dietary supply parasite challenge indicating role immunity reproduction gene expression induced upon parasite exposure food treatments suggesting infection related interference hosts reproductive system findings highlight potential dietary modulate expression key enzymes involved biosynthesis reproduction thus idea dietary supply influence immune functions host parasite interactions elsevier inc rights reserved
osteoporosis serious health problem worldwide microrna post transcriptional regulator gene expression either promoting mrna degradation interfering mrna translation specific target genes plays significant role pathogenesis osteoporosis first demonstrated mir mir negatively regulated osteogenic differentiation mesenchymal stem cells vitro found mir expression increased mice glucocorticoid induced osteoporosis silencing mir signaling protected mice promoting bone formation inhibiting bone resorption last showed mir inhibited differentiation bone formation partly directly targeting bone protein vitro model together findings identified role mechanism mir negatively regulating inhibition mir potential new strategy treating osteoporosis bone defects published elsevier
background multiple sequences arises many tasks bioinformatics however produced current software packages highly dependent parameters setting relative importance opening gaps respect increase similarity choosing one parameter setting provide undesirable bias steps analysis give interpretations work multiple sequence alignment multiobjective point view goal generate several sequence represent trade maximizing substitution score minimizing number gaps sum pairs score function trade gives practitioner information similarity sequences analyse choose plausible alignment methods introduce several heuristic approaches based local search procedures compute set sequence representative trade two objectives substitution score several algorithm design options discussed analysed particular emphasis influence starting alignment neighborhood search definitions overall performance perturbation technique proposed improve local search provides wide range high quality results conclusions proposed approach tested experimentally wide range instances performed several experiments sequences obtained benchmark database evaluate quality results calculate indicator set score vectors returned algorithms results obtained allow identify reasonably good choices parameters approach compared method terms correctly aligned pairs ratio columns correctly aligned ratio respect reference experimental results show approaches obtain better results omega terms first ratio
background psoriasis one common dermatological conditions seen daily practice psoriasis known associated lipid profile abnormality increased fasting blood glucose levels increased waist circumference increase blood pressures collectively constitute called metabolic syndrome objectives study serum lipid profile among psoriasis patients attending hospital study serum lipids relation severity psoriasis among patients materials methods study conducted medical college hospital research centre patients newly diagnosed psoriasis received prior topical systemic treatment randomly selected study matched age sex matched controls complete lipid profile estimated measurement blood pressure collection data blood samples collected obtaining proper consent cases controls serum lipids measured enzymatic method results total consecutive cases psoriasis screened examined recruited detailed history taken thorough examination carried age sex matched controls also recruited blood tests carried assess levels total cholesterol ldl hdl majority patients belonged years age group male female ratio patients mild psoriasis psoriatic arthritis noted patients cases patients concomitant diabetes patients hypertension amongst various lipid parameters slight elevation found triglyceride values parameters like hdl ldl total cholesterol show significant association correlation abnormality lipid parameters severity disease conclusion study show association psoriasis abnormality lipid profile reports west association explained basis increased prevalence obesity abnormal bmi hypertension compared indian patients
rail transit construction developing bounds china traditional project management model shown discomfort management modern concept project management provides new management model rail transit construction management becomes effective way change shortcomings traditional project management paper bases analysis characteristics requirements rail transit construction management presents management system based integrated management thoughts analyses overall frame operation mechanism virtual reality decision support dynamic control proposes strengthen constructions three aspects including organizational institutional runtime environment platform technology ensure management system rail transit construction running safely
paper describes development decision support tool positioning sizing vortex flow controls existing systems tool aims placement vortex flow controls primarily within greatest flood consequence rating use volumes critical rainfall events decision support tool intended use opportunities implement rainwater harvesting flooding limited decision support tool identify potential strategies enhance flood resistance systems cost effective manner authors published elsevier ltd
social identity theory suggests people use social categories race gender basis interpersonal judgments demonstrate biases favoring discrimination groups includes personnel decisions research examines whether context information participants use persons religion show typical intergroup biases often seen racial groups one hundred seventy five black participants viewed job different black white thirty two percent participants explicitly reported using religion seldom reported using race source evaluation showed consistent preference ingroup outgroup contrast using religion showed racial ingroup bias none religion research implications workplace discrimination practices racial religious group relations western social science association published elsevier inc rights reserved
several built recent decades mostly integrated downstream faces concrete dams among changing bottom slopes comprehensive information effect slope change flow features lacking paper reports systematic study air flow flow along vicinity slope changes physical modelling conducted using large facility pseudo bottom slope changes degrees degrees degrees degrees air water flow measurements conducted several flow cross sections upstream downstream slope change results indicate significant influence slope change air pattern flow four main flow sub regions identified describe typical air water flow patterns normalized length influence reach induced slope change found depend mainly critical flow depth regardless slope change step height
aim evaluate risks medical conditions evaluate gastric assess treat vertical methods performed frequently worldwide treatment medically complicated obesity common post hypothesize post operative related underlying medical conditions gastric retrospective single institution study consecutive patients underwent patients previous bariatric procedures excluded gastric includes inability pass due stenosis sharp passage results consecutive patients included prevalence patients sharp stenosis patients underwent gastric resolved patients patients noted resolution two additional multivariate model medical conditions associated post operative include diabetes mellitus symptoms esophageal reflux low whole blood level hypothyroidism use non steroidal anti inflammatory drugs use opioids conclusion gastric gastric stenosis common endoscopic gastric patients
paper describes new design system converting hydrocarbon fuels pure hydrogen system based reactor operating elevated pressures followed membrane based hydrogen separation high pressure membrane discharge stream expanded turbine generating additional power process simulation modeling illustrates effect pressure operating parameters system performance demonstrates system efficiency approaching coupled fuel cell electrical generator fuel electricity efficiency anticipated benefits system include compact size simplicity control fast start elsevier rights reserved
paper reported activities laboratory manufacturing technology manufacturing engineering focusing onto recent trends developments advanced manufacturing advanced materials mainly emphasizing long standing russian scientific cooperation also international involvement worldwide principal research important engineering topics nowadays industrial research academic point view engineering nanotechnology net shape manufacturing high temperature ceramic elsevier rights reserved
mortality morbidity attributed asthma remains biggest worldwide hence study aimed compare metabolic risk factors assessed body mass index bmi waist hip ratio serum uric acid controlled poorly controlled correlate parameters severity asthma case control study conducted subjects controlled poorly controlled diagnosed based global initiative asthma management guidelines healthy volunteers fasting venous blood samples used biochemical analysis pulmonary function test bmi waist hip ratio measured statistical analysis done using spss version significant increase bmi lipid profile serum uric acid decrease forced volume forced vital capacity fvc fvc poorly controlled significant association serum uric acid bmi poorly controlled poorly controlled greater risk developing cardiometabolic problems serum uric acid used one severity markers asthma assess metabolic risk
derivation input sequences distinguishing states finite state machine specification studied context based functional testing present three heuristics derivation distinguishing sequences specifications first based cost function guides derivation process second genetic algorithm evolves population individuals possible solutions input sequences using fitness function crossover operator specifically tailored considered problem third heuristic mutation based algorithm considers randomly generated input sequence candidate solution candidate distinguishing sequence algorithm tries find solution appropriately considered candidate experiments conducted assess performance considered algorithms respect execution time virtual memory consumption quality length obtained sequences experiments conducted using randomly generated machines various number states inputs outputs degrees non assess impact varying number states inputs outputs degree non elsevier rights reserved
purpose study examine compare teaching behaviour female male preschool teachers concerning teaching style emotional support support exploration gender activities additionally study tested association gender roles masculinity teaching styles emotional support provided opportunities exploration results indicated four teaching styles male teaching styles often emotionally reserved comparison female ones female teachers offered often verbal physical emotional support compared male teachers gender differences found regarding support exploration general female teachers offered female gender activities compared males warmth support males teaching style positively related psychological pressure males teaching style negatively related masculinity
investigating association nerve growth factor levels vaginal mesh surgery able associate likelihood postoperative lower urinary tract symptoms developing result synthetic mesh implanted pelvic floor surgery eight female sprague dawley rats divided three groups mesh sham mesh control urodynamic study analysis tissues done results compared among groups urodynamic studies mesh sham groups divided days value considered statistically significant rats survived complications observed post implantation period histological evaluation showed intense acute inflammatory reaction days mesh sham groups compared control mesh group showed larger area inflammation compared sham levels increased significantly mesh sham groups days compared control respectively mesh sham groups shorter voiding interval lower voiding volume days compared control group respectively magnitude increasing level decreasing voiding interval voiding volume significantly mesh group sham group higher level early days post mesh implantation associated shorter voiding interval smaller bladder capacity represents abnormal lower urinary tract symptoms following mesh implantation
demonstrated results perinatal outcomes cost patients advanced age tertiary centre total patients two groups according age group years group years analysed retrospectively addition subgroup analysis performed according years cut clinical pregnancy rate significantly different groups preterm delivery gestational week low birth weight significantly higher advanced aged women mean expense per cycle hormonal stimulation groups respectively mean expense per pregnancy groups respectively study showed perinatal outcomes cost adversely affected increasing age
water treatment creates aggregated particles large enough removed downstream processes sedimentation filtration beds sometimes included sedimentation processes significantly improve sedimentation tank particle removal plate tube used overall performance sedimentation tank containing influenced characteristics incoming provide additional opportunity aggregation particles enables reduction size improving particle removal efficiency study laminar flow varying velocity gradient residence time theta tested laboratory scale water treatment results indicate increasing range decreasing residence time maintaining constant theta similar improved particle removal results indicate velocity gradients greater existing design recommendations used reduce residence times associated construction costs sedimentation plate tube employed subsequent reduction residence time resulted water turbidity turbidity unit varying theta constant effluent turbidity observed middle residence time tested theta suggesting long hydraulic residence times suboptimal
consider random associated graphs generated point processes suitable assumptions point processes show almost realization point process random recurrent transient results hold large variety point processes including poisson point processes cluster processes clustering properties order prove state general criteria recurrence apply random graphs embedded elsevier rights reserved
goals goals study investigate distress syndrome pain syndrome gastric electrical activity gastric time together circulating concentrations releasing factor establish whether genetic variability system genes differs categories functional background current classification based symptoms proven completely satisfying high degree symptom overlap subgroups study gastric electrical activity evaluated cutaneous time acid breast test circulating concentrations gut peptides measured snps evaluated pcr digestion results fifty four patients female male studied using symptom questionnaire patients classified although overlap symptom profiles subgroups recorded parameters instability coefficient dominant frequency dominant power power ratio significantly different subgroups whereas time differ significantly addition characterized different gut peptide profile compared finally polymorphism shown associated levels evidence deserves studies consideration analgesic role conclusions analysis gut peptide profiles represent interesting tool enhance diagnosis overcome limitations due distinction based solely symptoms
carbon produced process using foam layer resin precursor process conducted vacuum conditions inverted perpendicular conditions determined basis carried thermogravimetric analysis basic mechanical properties like compressive strength carbon measured compared theoretical value furthermore carbon applied skeleton reinforcement epoxy resin matrix composites analysis mechanical properties revealed values hardness compressive strength materials spatial carbon foam almost two times higher pure matrix applied reference material major factors influenced final mechanical properties quality obtained amount carbon material volume moreover proved application carbon foam low mechanical properties led significant increases compressive strength composite materials
paper presents approach aimed mining new type pattern data namely proportions proportion expresses equality relationships attributes two pairs structured objects notion investigated database context discovery different forms pairs first give formal definition proportion setting relational databases focus problem mining proportions propose use clustering approach occurring relation thus discovering proportions
long non coding rnas emerged recently important factors regulating fundamental biological processes alterations expression function observed promote tumor formation progression metastasis although downregulation expression levels let several tumors reported role gastric cancer remains unknown aim present study investigate expression function let gastric cancer development expression levels let pairs gastric cancer adjacent non tumor tissues detected reverse transcription quantitative polymerase chain reaction qpcr addition let expression gastric cancer cell lines analyzed qpcr assay analysis furthermore impact let cell proliferation migration apoptosis detected using cell counting kit wound scratch elisa assays respectively results demonstrated expression level let downregulated gastric cancer tissues cell lines compared normal tissues normal human gastric epithelial cell line restoration let expression using synthesized recombinant overexpression vector transfected cells significantly inhibited cell proliferation migration promoted cell apoptosis vitro present study first demonstrate let function tumor suppressor gastric cancer results indicate let promising biomarker therapeutic target gastric cancer
high affinity dopamine receptors provide novel treatment drug addiction assessed effects acquisition expression extinction induced conditioned place preference furthermore effects conditioned association contextual stimuli natural reward examined using food induced separate experiments rats received injection conditioning expression induced extinction session induced placement compartment containing food conditioning although effect acquisition treatment acquisition dose dependently preference associated context quickly vehicle treatment moreover treatment facilitated extinction given repeatedly throughout extinction phase although expression affected administered prior expression test induced following extinction period blocked intermediate dose blocked acquisition food whereas high dose facilitated extinction preference compared vehicle treated animals therefore attenuates maintenance conditioned associations contextual stimuli food reward induced drug seeking behaviour candidate development pharmacological treatment drug dependence elsevier rights reserved
social cognition topic enormous interest much research far agreed taxonomy factor structure relevant processes aim review outline briefly known structure social cognition suggest progress made delineate dependence core processes focus particular several processes discussed tested together typical atypical notably autism spectrum disorder groups biological motion empathy theory mind consider domain specificity core processes social learning reward attention highlight potential relevance dual process theories distinguish systems fast automatic slow processing conclude methodological conceptual suggestions future progress structure social cognition
pulmonary fibrosis serious medical problem significantly compromise respiratory functions aim work study effect pulmonary fibrosis explore possible mechanisms underlying effect one hundred twenty male mice divided equal groups follows control group bleomycin group bleomycin group bleomycin group bleomycin group bleomycin group lung weight body weight index lung tissue collagen toll like receptor nuclear factor like heme malondialdehyde mda glutathione peroxidase catalase cat measured also bronchoalveolar lavage fluid analyzed total differential count lactate dehydrogenase tumor necrosis factor alpha tnf interleukin transforming growth factor beta tgf vascular response potassium chloride response measured also lung tissue subjected histopathological immunohistochemical examination administration induced significant decrease lung weight body weight index total count lactate dehydrogenase activity tnf tgf associated significant decrease lung tissue mda collagen content significant increase tissue cat improvement pulmonary architecture vascular response compared bleomycin group effects significant combination group compared use drugs alone conclusion combination represent effective therapeutic modality bleomycin induced pulmonary fibrosis elsevier rights reserved
carbon nanotubes nanomaterials attracted great research interest unique properties promising applications controllable synthesis broad application review consider nanoscale process engineering assess recent progress mass production ultra long inexpensive good alignment wall number diameter fundamental engineering science applications across multiple scales cutting edge nanoscale process engineering research areas physics chemistry materials engineering ecology social science allow obtain high added value multi functional advanced synthesis controllable good alignment predetermined sizes lengths still presents great challenges multidisciplinary scientific research advanced based materials promote development sustainable society
various applications like instance algorithm design mission planning geo change detection automatic target recognition sar data analysis rely simulated synthetic aperture radar sar images however different sar simulation techniques different advantages disadvantages depending needs certain application suitable sar simulation technique used paper compares three sar image simulation approaches showing similarities differences two ray tracing based sar image simulators based open source software ray developed sar simulator scratch third simulator real time sar simulator based approach geometrical features three simulators compared differences different applications analyzed authors published elsevier behalf international society photogrammetry remote sensing inc open access article license
development systems often described modeled terms principles related various hydraulic energy parameters generally principle efficiency selection efficient flow routes tend preferentially selected enhanced however efficiency selection highly localized cumulative effects local events produce efficient pathways broader scale illustrated case run stream central field evidence indicates stream analyzed using flow partitioning model represents efficient channel reach scale favor longer currently less steep less efficient flow path apparently occurred owing capture run flow subsurface flow path subsequently development illustrates local nature efficiency selection role historical contingency evolution elsevier rights reserved
projection mapping projection technology used turn objects buildings display surface video projection combination sensing technology projection mapping technology interactive performance expression achieved combined technology attracting attention called interactive projection mapping two types interactive performance using projection mapping one performance operation small number people performance lot people simultaneously take part latter requires technology achieve smooth computer graphics video processing enormous number requests audience narrow area university conducting performance projection mapping one events since organized large scale interactive performance projection mapping december developed interactive projection mapping system applied performance eventually system realized smooth interactive performance paper present scalable intelligent collaborative architecture large scale interactive projection mapping system show implemented system results performance
background aim weight gain stopping smoking potentially improvements cardiometabolic risks investigated changes metabolic syndrome mets components homeostasis assessment model insulin resistance smokers given dietary counseling quit attempt methods results smokers cigarettes day bmi randomized low carbohydrate low fat diet treated standard course weeks assessed according standard cigarettes quit date validated breath carbon monoxide ppm randomized participants completed clinical laboratory assessments weeks changes metabolic risk factors differ dietary groups combined groups compare continuing smokers found similar weight change among validated continuing smokers change waist circumference changes triglyceride concentrations mmol mmol diastolic blood pressure mmhg mmhg favorable changes cardiometabolic risks differ continuous smokers energy intake resting metabolic rate conclusion dyslipidemia blood pressure improved early weight gain seen suggesting dietary intervention mitigate effects stopping smoking cardiometabolic risk factors overweight obese smokers italian society italian society study atherosclerosis italian society human nutrition department clinical medicine surgery university published elsevier rights reserved
reach legislation requires chemicals including petroleum substances put market quantities greater year tested prenatal developmental toxicity require large numbers animals since prenatal development toxicity testing animal intensive application technologies reduce number animals study prenatal developmental toxicity petroleum substances allowing grouping categories toxicological properties substance categorization supported similarities molecular developmental toxicity effects observed oil products likely related aromatic hydrocarbons high molecular weight however current review indicates even though available studies provide clues regarding family genes regulate functions skeleton development single individual genes used biomarkers exposure subsequent prenatal developmental toxicity furthermore considered technologies applied specific tissues organs testing lead unreliable results regarding developmental toxicity due induction tissue specific pathways thus approach applies battery vitro tests including zebrafish embryo test embryonic stem cells whole embryo culture suggested relevant studying developmental effects terms substances categorization elsevier ltd rights reserved
fluid mechanics solve multiple solutions ordinary differential equations always concerned difficult problem improved rna genetic algorithm inspired rna molecular structure operators proposed solving parameter estimation problems multiple solutions described flow fluid porous channel expanding walls paper multiple solutions found changing accuracy search coverage multi iterations computer last ordinary differential equations calculated result great accuracy method practical authors published elsevier ltd
reported higher risk maternal fetal complications women myeloproliferative neoplasms mpn poses challenge pregnancy national prospective study maternal fetal outcomes pregnant women diagnosis mpn undertaken via united kingdom obstetric surveillance system january december fifty eight women diagnosis mpn identified essential five vera five myelofibrosis one mpn live births incidence confidence interval perinatal mortality rate live incidence maternal complications pre post post maternal deaths thrombotic events delivery induced women section rate majority delivered term gestation twenty two percent neonates growth required admission neonatal care unit neonatal deaths findings large prospective study suggests women mpn appear successful pregnancies better outcomes anticipated literature
many low mid power applications critical mode boost power factor converters widely used low switching loss simple control however near zero crossing input line voltage input current distortion low power factor caused delayed switching period negative input currents generally additional time method according input voltage used compensate input current distortion however detailed quantitative analysis exact additional time studied till now paper explicit form optimized additional time obtained using quantitative analysis advantage digital control state trajectory net input charge analysis shown optimized time related input voltage also output power also order improve efficiency high input light load condition circulating currents reduced inevitable dead angle gate turning technique using digital control optimized additional time gate turn technique implemented rms input output prototype
technology illustrate software codes contexts effects agencies shape urban space everyday life consequences code nature remain understudied political remote sensing geographic information systems gis based conservation projects engaged broadly role software production circulation application ecological knowledge yet around world data analytics firms conservation argue optimizing environmental management faster bigger data collection new techniques data manipulation visualization present case study state illustrating environmental regulators employ computer programming plan markets restore stream wetland ecosystem services offset credits markets code executed algorithms web maps gis utilities generate relate make sense data define credit argue code tends toward three effects producing landscape defined modeled value performing social relations associated moves although emphasis code technological objects warranted contexts deployed evaluated remain central understanding environmental governance caution seeing technology reducing nature society state differentiate codes work space nature call bridging political ecology technology ways explain code generative environmental knowledge change conflict
transgender college students struggle identity formation emotional social developmental challenges associated emerging adulthood potential maladaptive coping strategy employed students heavy drinking prior literature suggested greater consumption negative alcohol related consequences transgender students compared peers little known differing experiences alcohol related examined level alcohol consumption frequency motivations drinking reported largest sample transgender college students date methodsa web survey alcohol prevention program college assessed student demographics drinking related behaviors experiences motivations newly first year college students self reported drinking used examine following measures previous number drinking days total number maximum number single day point likert scale used measure drinking motivations transgender students sexes compared peers resultsa total students identified transgender day period transgender compared students likely consume alcohol days total greater number maximum single day transgender students likely report students negative academic related social sexual transgender respondents often cited stress reduction social anxiety self esteem issues inherent properties alcohol motivations drinking nearly measures higher values yielded male female female male transgender students compared first year students engage higher risk drinking patterns experience negative broad institutional efforts required address unique circumstances transgender men women reduce negative college students regardless sex gender identity
present methodology based matrix factorization gradient descent predict number sessions established access points network according users behavior network considered work monitored controlled software order manage users resources real time consider cyber physical system interacts physical world access points whose demands predicted according users activity predictions useful reinforcing access points according changing physical environment work propose prediction model based machine learning techniques validated comparing prediction results real users activity experiments collected activity users demanding network sessions one month network composed access points results qualitatively valid regard previous knowledge conclude proposal suitable predicting demand sessions access points devices removed taking account usual activity network users elsevier rights reserved
purpose study investigate prevalence hypothyroidism among hospitalized patients type diabetes mellitus related factors assess prevalence microvascular diseases among type diabetes mellitus inpatients hypothyroidism total type diabetes mellitus inpatients hospitalized metabolic diseases hospital medical university january march included study information demographic anthropometric factors additional variables related hypothyroidism collected medical records prevalence rates calculated standardized using direct method based age specific sex specific structure participants data analyzed using binary logistic regression adjustment potential confounders prevalence hypothyroidism among type diabetes mellitus inpatients patients hypothyroidism subclinical hypothyroidism prevalence hypothyroidism increased age higher women men older age odds ratio confidence interval female gender odds ratio confidence interval positive thyroid peroxidase antibody odds ratio confidence interval associated higher odds hypothyroidism among type diabetes mellitus inpatients type diabetes mellitus inpatients hypothyroidism higher prevalence cerebrovascular diseases adjustment age gender prevalence hypothyroidism among type diabetes mellitus inpatients patients subclinical hypothyroidism older age female gender positive thyroid peroxidase antibody indicators detecting hypothyroidism type diabetes mellitus inpatients
fasting positively associated morbidity coronary heart disease chd non fasting also correlated risk status chd related increase produced intestine particles oxidized low density lipoprotein ldl low density lipoprotein highly act enhancing systemic inflammation platelet activation coagulation formation macrophage foam cell formation cholesterol levels significantly correlate small dense ldl impaired glucose tolerance chd prevalence developed assay apolipoprotein levels evaluate accumulation fasting levels correlate morbidity obesity type metabolic syndrome hypothyroidism chronic kidney disease fasting levels also correlate carotid media thickening chd prevalence high level significant predictor chd risk independent fasting level diet interventions dietary fibers medium chain fatty acids long chain polyunsaturated fatty acids ameliorate moreover drugs dyslipidemia diabetes concerning inhibitor like peptide analogue improve since accumulation correlates impaired lipid glucose metabolism atherosclerotic cardiovascular events studies required investigate characteristics physiological activities functions development new interventions reduce
smart environments spaces interact users taking account needs preferences systems manage environments need manipulate context interacting suitable way users one big challenge creating smart environment deal context ideally computer supported environments detect relevant events forecast future situations act mitigate eliminate situations related specific users needs paper proposes framework providing extensible reactive proactive behavior smart environment systems focus present work related specific class smart environments ambient assisted living sense define framework illustrate practical aspects use framework describing home care scenario system behavior user time goes detects relevant situations acts preserving user health condition
paper presents results investigation performance efficiencies fabrics turbidity sediment concentration removal determination flow rate simulated construction sites real time two fabrics woven type nonwoven type subjected material index property tests series field scale tests fabrics tested removal efficiency varying rainfall intensities events different slopes test bed collected effluent samples analyzed sediment concentration turbidity flow rate fabric evaluated test results revealed woven nonwoven achieved percent average turbidity reduction efficiency percent average sediment concentration removal efficiency respectively evaluation sediment concentration reduction based percent removal correctly account sediment concentration transported deposited downstream fabric functions rainfall intensity slope field conditions every rainfall event elsevier ltd rights reserved
investigation paper discrete dimensional equation certain applications nonlinear optics condensation employing hirota method symbolic computation obtain bright dark one two three soliton solutions asymptotic analysis indicates interactions bright dark two solitons elastic amplitudes velocities bright dark solitons increase value coupling strength increasing head interactions bright two solitons bound state two solitons depicted interaction dark two solitons also plotted increasing value coupling strength lead increasing amplitudes velocities bright dark two solitons published elsevier
study synthetic vaccine nanoparticles efficiently targeted lymph nodes immune responses foreign antigens primed developed enhance antitumor immunity size surface character poly gamma acid based selected effective loading delivery migration retention model tumor antigen toll like receptor agonist poly immune cells lymph nodes antigen presenting cells treated showed higher uptake poly higher secretion inflammatory cytokines tnf alpha type interferon ifn alpha ifn beta treated poly alone vivo analysis revealed higher levels activation markers inflammatory cytokines type lymph nodes mice compared mice groups treated mice showed significantly greater vivo natural killer cell expansion activation cells cell response gamma cells innate adaptive immunity respectively preventive therapeutic vaccination tumor bearing mice using simultaneous injection induced higher antitumor immunity inhibited tumor growth elsevier ltd rights reserved
nowadays companies emphasis making supply chains supply chain perspective carriers always looking increase container tracking reducing costs time regarding customer service improvement hand every needs informed last position situation paper different methods tracking companies based satellite radio frequency identifier global system mobile communications discussed eventually end end integrated intelligent tracking method introduced regarding customers requests needs availability cost different methods customer requirements proposed model key parameters according model efficient end end container first stage release last stage return destination considered
modern days information communications technologies lead devices every type connected internet also need protection cyber attacks virtually devices wireless connection vulnerable malicious attempts meanwhile based mechanism considered one methods ensure security modern networks internet things iot paper address problem attacks enabled networks looking game theoretic model involving attacker attacker try employing different types attacks ranging seemingly normal activity turn make use tool trap attackers problem modeled bayesian game incomplete information identified one shot game repeated game versions results show threshold frequency active attackers players take actions mix strategy keeping attackers success rate low
offer unique opportunities establishing neurobiological basis thinking regards causal factors review literature suggests neither executive impairment sole perhaps even primary cause beliefs though act factors key perspective modern literature many emotionally positive element serve modulate manage emotional experience authors referred perspective emotion dysregulation hypothesis article review theoretical underpinnings approach develop idea suggesting positive aspects states role imbalance cognitive control emotion draw existing evidence fields outside argue three main causal factors positive emotions related global forms cognitive processing positive emotions influence accuracy memory positive emotions make people susceptible false memories findings suggest emotions want feel want feel influence way reconstruct past experiences generate sense self unified theory belief states crown copyright published elsevier ltd rights reserved
background ablation relatively new procedure treating benign thyroid nodules purpose study evaluate safety efficacy treating benign thyroid nodules serve reference future clinical practice methods study retrospectively analyzed clinical data patients receiving percutaneous treating thyroid nodules november july medical center one hundred eight patients total nodules received ultrasound guided treating thyroid nodules comparisons volume change thyroid nodules treatment post treatment complication change thyroid function carried afterwards results treatments patients received fine needle aspiration biopsy supported diagnosis benign tumor males females included study twenty six cases single cases multiple nodules treatments thyroid functions tsh normal originally adjusted normal range treatment preoperative nodules minimum volume maximum volume mean volume volume nodules one month three months respectively addition volume reduction ratio nodules one month three months respectively volume nodules statistically significant differences pre operative post operative comparison thyroid functions normal range treatments serious complications conclusions ultrasound guided treating benign thyroid nodules advantages definite efficacy safety strong control ability less damage surrounding normal tissues effect thyroid function used one main treatment methods treating benign thyroid nodules
background important effector cells involved pathogenesis inflammatory skin diseases including chronic urticaria associated increased serum levels far effects human unknown objective analyse functional role biology methods expression evaluated skin samples derived chronic spontaneous urticaria patients receptor receptor protein expressions analysed human healthy donors responses assessed release histamine results expressed human strongly expressed skin patients chronic spontaneous urticaria released isolated following either anti ige stimulation induced release specifically inhibited anti anti conversely effect histamine release conclusions clinical relevance human source activated release pro inflammatory cytokines induction indicating important novel function biology
despite widespread clinical use remain questions regarding dosing treatment times affect efficacy injury dosing treatment times directly related degree cooling necessary effective lesion formation human atrial ventricular lung tissues using two systems concurrent infrared post samples cultured stained differentiate viable non viable tissue matlab code correlated viability staining applied thermal cycles determine injury thresholds tissue regions classified live injured dead based upon staining intensity lesion margin injury begins rates degrees min degrees non viable tissue requiring cooling rates close degrees min degrees significantly greater cooling degrees human tissue similar rates lung tissue injury began degrees human tissue requiring significantly less cooling degrees complete necrosis degrees data suggest significant differences human myocardial response differences human lung tolerance elsevier inc rights reserved
security quantum key distribution relies uncertainty principle legitimate users able estimate information leakage monitoring disturbance transmitted quantum signals normally disturbance reflected bit errors key thus privacy amplification removes information key generally depends bit error rate recently round differential phase privacy amplification rely bit error rate nature proposed amount information bounded state preparation stage hence independent behavior unreliable quantum channel work apply technique protocol present tight bound key rate employ state method effects background noise taken account practical conditions simulation results show protocol tolerate channel error rates close within typical experiment setting negligible restriction error rate practice
according life combustion extent humans adapt changes food intake adaptive turning rate heat production energy deficit energy turning excess one controversial issues nutritional sciences past years debate nowadays whether adaptive exists rather quantitative importance weight clinical relevance pathogenesis management obesity uncertainties likely persist future primarily limitations measure changes energy expenditure body composition high enough accuracy precision particularly even small inter individual variations dynamic systems long term important determining weight maintenance obesity weight others paper reviews considerable body evidence albeit suggesting existence quantitatively important adaptive several compartments energy expenditure response altered food intake discusses various limitations lead assessment including semantics technical methodological analytical statistical role adaptive human weight regulation likely remain concept strictly entity future evolution concept continues fuel exciting hypothesis driven mechanistic research contributes advance knowledge human metabolism bound result improved strategies management healthy body weight
technical note proposes noise tolerant neural network design formula shows recurrent recursive methods solving time varying problems designed viewpoint control design formula provides control theoretic framework deal convergence stability robustness issues continuous time discrete time models models derived proposed design formula demonstrate advantages applied solving time varying zero finding problems presence noises
strong relationship scientific research technology advancement former generally focuses studying phenomena real world latter improves tools basis research perspective information communication technologies allow implementation ever faster tools analyzing data generated experiments aim project study interaction upper earth atmosphere global navigation satellite systems signals received ground critical environments polar regions paper describes ict infrastructure used manage software applications used analyzed data collected project experimental campaigns taking account following constraints intellectual property applications protected underlying infrastructure resembles cloud federation iii data sized provide unified vision available resources user available applications experimental data reside leveraging lightweight virtualization system proposed management system four constraints case study used show process deploying application proposed system specific node data interest reside
parent child interaction therapy evidence based family intervention young children disruptive behavior parents children complete show greater immediate long term treatment gains treatment time effort intensive treatment parents ambivalent value child ability master treatment skills treatment engaging sufficiently experience change motivational interviewing client centered therapeutic method increasing motivation change resolution paper describes clinicians incorporate strategies enhance parental motivation signs arise therapy exchanges illustrate use strategies decrease improve adherence increase parenting self efficacy reduce attrition thereby improving outcomes young children disruptive behaviors families
introduction frequent acquired disorder neuromuscular transmission majority cases pathogenic antibodies components muscle membrane detected recent years significant advances pathophysiological understanding therapy covered pubmed searches conducted term cross referenced terms immunology subgroups antibody ocular treatment additionally summarized current state commentary immunological research defined new target antigens neuromuscular junction along clinical features allow refined definition disease subgroups overall prognosis best possible symptomatic immunosuppressive supportive treatment good new immunomodulatory treatment options developed patients respond first line therapy patients individually adapted long term drug therapy needed
development power electronic technology control technology power electronic device becoming complicated switching power supply indispensable component modern power electronic equipment quality size direct impact whole performance electronic equipment digital control technology applications fpga become new research field power electronics digital control reduce aging device impact temperature drift accuracy convenient paper studies digital switching power supply based fpga points system structure system
seasonal affective disorder sad major depressive disorder fall winter caused reduction light environment depressive symptoms alleviated bright light therapy circadian systems implicated etiology sad however underlying neural pathways light regulates mood understood present study utilized diurnal rodent model explore neural pathways mediating effects light brain regions involved mood regulation animals kept constant received light exposure early subjective day time light therapy usually applied time course neural activity following light exposure assessed using fos protein marker following brain regions cells nucleus neurons lateral hypothalamic area dorsal nucleus light induced increase fos expression observed neurons inputs involvement signaling mediating effects light tested second experiment animals injected selective receptor type antagonist prior light exposure treatment significantly inhibited fos induction results collectively point role neurons mediating effects light mood regulating areas suggesting pathway underlies light dependent mood fluctuation beneficial effects light therapy ibro published elsevier ltd rights reserved
background standard replacement therapy disease restore normal circadian rhythm periods sub physiological cortisol levels experienced patients likely induce disrupted sleep given healthy sleep plays important role memory consolidation novelty current study characterise using objective measures relationship sleep memory patients examine hypothesis poor sleep biological mechanism underlying memory impairment patients methods used within subjects design ten patients matched healthy controls completed standardised neuropsychological tests assessing declarative memory auditory verbal learning test procedural memory finger task period sleep period results relative healthy controls patients experienced disrupted sleep characterised poorer sleep efficiency time spent patients also showed impaired verbal learning memory relative healthy controls furthermore whereas healthy controls declarative memory performance benefited period sleep compared patients derived benefit sleep regarding procedural memory task analyses detected significant group differences neither group showed significant sleep enhanced performance conclusions demonstrated using actigraphy standardized measures memory performance association sleep disturbances cognitive deficits patients results suggest patients source memory deficits least extent disrupted sleep patterns interfere optimal consolidation previously learned declarative information hence treating sleep disturbances frequently experienced patients improve cognitive functioning elsevier ltd rights reserved
individuals merely passive vessels beliefs opinions exposed rather attracted belief systems psychological needs interests including relational needs attain certainty security social demonstrated needs manage uncertainty threat associated core values political namely respect tradition acceptance inequality since far studies psychology left right ideology preceding half century empirical yield helps address questions identified studies motivation involving individual participants nearly studies motivation involving participants databases much larger heterogeneous used previous meta analyses confirm significant ideological exist respect cognitive perceptual rigidity personal needs order structure closure integrative complexity tolerance ambiguity uncertainty need cognition cognitive reflection self subjective perceptions threat exposure objectively threatening circumstances attacks governmental shifts racial contribute modest conservative shifts public opinion also ideological relational motivation including desire share reality perceptions within group consensus collective self efficacy homogeneity social networks tendency trust government ones political party power although object notion meaningful psychological differences identification elective affinities cognitive motivational processes contents specific belief systems essential study political psychology political psychologists contribute development good society ideological differences swiss style comes human values investigating phenomena critically even perhaps especially pressure society view
group recently developed novel covered carotid prevent preserving external carotid artery branch blood flow however recent vitro side branch flow preservation tests covered revealed need frame design improvements including consideration low profile delivery system bigger cells hence current work aims design new bare metal bigger cell size improve accommodate side branch flow increased three new designs analyzed using finite element analysis two commercially available carotid terms mechanical performances radial strength flexibility results indicated new bare metal designs matched commercial hence new generation covered based designs expected perform better side branch flow preservation without compromising mechanical performances
catalyzes reversible reaction hydration dehydration back industrial processes breathing air require large amount highly active stable therefore objectives present study large amounts cheap easily accessible source enzyme characterize enzymatic kinetic properties soluble immobilized enzyme recovered pure enzyme specific activity protein single step using sheep blood house waste products specific inhibitor affinity chromatography since affinity pure showed esterase activities measured esterase activities enzymology constant optimum activation energy thermal stability soluble enzymes mol respectively immobilization enzyme efficient purified enzyme immobilized immobilized enzyme showed activation energy mol suggesting better preference substrate immobilized enzyme comparison soluble enzyme contrast soluble enzyme immobilized enzyme showed relatively higher activity results concluded shift profile toward acidic due modification lysine residues involved immobilization process immobilized enzyme stable higher temperatures showed highest activity degrees activity immobilized enzyme flow reactor min flow rate unaffected collectively results present study suggested application blood waste animal purification homogeneous enzyme capture flow reactor elsevier ltd rights reserved
active membrane transporters dynamic molecular machines transport across membrane coupling solute movement source energy atp secondary ion gradient central question many active transporters concerns mechanism transport coupled source energy transport process associated energetic coupling involve conformational changes transporter efficient transport conformational changes tightly regulated link energy use movement substrate across membrane present review discusses active transport using established energetic framework enzyme mediated catalysis particular membrane transport systems viewed consisting low energy high energy transport process involves binding interactions selectively stabilize higher energy way promote conformational changes system coupled decreases free energy substrate translocation major superfamily secondary active transporters used illustrate ideas expanded primary active transport mediated abc atp binding cassette systems focus studied transporter
faculty mechanical engineering department materials engineering czech republic causes cracking problems related welding steel alloy described welding procedure used root main characterized tendency metal cracking region test microstructural analysis performed supplemented measurements impact test analysis carried microstructure exhibited presence hard particles mostly oxide region region presence negative effect oxide presence probably caused technological discrepancy
smart home field witnessed rapid developments recent years internet things applications smart home heterogeneous continuously increasing number making user management security perspective challenging moreover resource constrained nature devices implies security mechanisms deployed lightweight highly efficient article propose authentication scheme based symmetric key cryptography combined capability based access control system provide different stakeholders residents temporary end end secure access internet things devices smart home managed home owner anonymous way operations scheme include small number communication phases protect identities entities involved stakeholders end nodes outside entity proposed scheme ensures even stakeholders device internet things device system remains secure
background fluid csf brain two main ventricular csf space csf changes csf seen many neurological conditions including multiple sclerosis found correlate clinical outcomes aimed test relation ventricular csf cognitive impairment based minimal assessment cognitive function patients material six patients underwent battery classified cognitively impaired borderline patients volumes ventricular csf along global gray white matter volumes cortical thickness obtained diffusion tensor imaging dti weighted based segmentation measures statistically analyzed associations adjusting age education years lesion load disease duration csf showed strongest correlation cohort whereas ventricular csf along cortical thickness gray matter volume failed show significant correlation group analyses unadjusted multiple comparisons showed significant difference volumes csf ventricular csf groups csf correlates patients possibly explained cortical atrophy dti based csf segmentation method used indirect simple neuroimaging marker monitor patients
parkinsons disease progressive neurodegenerative disorder characterized loss dopaminergic neurons substantia nigra gradual depletion dopamine current treatments deficit improve symptoms induce time neuroprotective therapies report nuclear receptor related receptor alpha alpha activation double therapeutic potential offering neuroprotective symptomatic improvement designed unique vivo active alpha selective lead molecule prevents neuron striatal vivo causing toxins dependent manner also protects related genetic mutations patient induced pluripotent stem cell derived neurons genetic mouse model remarkably besides regulates tyrosine hydroxylase aromatic amino acid transcription increases striatal vivo symptomatic efficacy two models without inducing chronic daily treatment combined neuroprotective symptomatic effects identify alpha activation potential approach
previously developed bio place bio instrument fabricate large tissue constructs scaffold free living integrated bio required mechanism manipulate living various sizes shapes fragile remain aqueous environment optical transparency bio device essential provide accurate alignment previously engineered pilot fluid force driven bio place planar position without causing cellular damage culture medium track membrane integrated cell culture study new flexible bio design maximized bio utilities utilized experimental approaches multivariate analyzes theoretical modeling elucidate membrane characteristics pore size pore density membrane thickness membrane area surface chemistry altered bio robustness flow rate required successful devised two standardized tests synthetic parts systematically quantify bio performance thirteen pump driven bio except one successfully released synthetic parts values mathematical simulation fluid mechanics bio synthetic parts various sizes shapes masses demonstrating robustness mechanism multivariate analysis experimental data indicated membrane porosity thickness modulated addition revealed membrane pore density determined membrane optical transparency large tissue constructs requires repeated showed one bio place living thirty times corresponding simulation bio capable twenty summary successfully engineered robust controllable fluid driven bio efficiently manipulate living micro objects aqueous environment
genus consists gram positive anaerobic bacteria slightly curved rod shaped means multiple includes five species gut spp dietary components stimulate proliferation metabolic activities part bacteria producing short chain fatty acids especially affecting colonic motility immunity maintenance anti inflammatory properties modification spp representation affect various metabolic pathways associated several diseases including irritable bowel syndrome obesity type diabetes nervous system conditions allergies spp also serve biomarkers symptomatic pathologies formation probiotics restoration beneficial flora
background widely used treat infections caused simplex virus virus common adverse effects drug include nausea diarrhea headache dizziness mental changes immune thrombocytopenia induced rare case presentation year old chinese male given hourly treatment infection developed severe thrombocytopenia sign oral cavity within days starting using patients condition improved stopping using supportive treatment dependent platelet antibody test showed positive results implicated causative agent final definitive diagnosis induced immune thrombocytopenia established time correlation start using onset symptoms thrombocytopenia combining excluding common causes thrombocytopenia conclusion reports induced immune thrombocytopenia first case report literature review induced immune thrombocytopenia first sign never rare adverse effect rapid appropriate treatment prevent severe life threatening complications
indigenous first nations people canada high chronic disease morbidity resulting part enduring social obesity prevention strategies developed first nations people crucial improving health status group research objective develop community relevant strategies address childhood obesity first nations community strategies derived action based workshop based analysis grid environments linked obesity framework thirteen community members wide ranging community representation took part workshop combined personal knowledge experience community specific national research dissect broad array environmental factors influenced childhood obesity community developed community specific action plans focusing healthy eating physical activity children families actions included increasing awareness childrens health issues among local population community leadership promoting nutrition physical activity school improving opportunities strengthening childrens connection culture considered paramount improving thus workshop participants developed programmes included teachers reinforced families first nations foods activities research demonstrated framework participatory way develop community driven health programmes also demonstrated first nations people involved creation solutions health issues communities focus approaches strengthening connection indigenous culture external available implement programmes formal follow determine community members implemented programmes future research needs examine extent community members implement programmes whether community action plans implemented lead short long term benefits health outcomes
study presents self testing platform digital calibration technique successive approximation register sar analog digital converters high accuracy digital analog converter dac digital control used proposed self testing platform generate sinusoidal test signal signal implemented using arduino board clock signal generated test addition fast fourier transform recursive discrete fourier transform processors adopted dynamic performance evaluation calibration third harmonic distortion caused non linearity track hold circuit mismatch dac capacitor array direct current offset comparator calculated using processors improve adc performance advantages proposed platform include low cost high integration need extra analogy compensation circuit deal calibration work bit sar adc processor used taiwan semiconductor manufacturing ltd tsmc standard complementary metal oxide semiconductor cmos process sampling rate validate proposed method measurement results show signal noise distortion ratio calibration calibration
background mobile health services becoming increasingly important form information communication technology ict enabled delivery healthcare especially low resource environments developing countries like despite widespread adoption mobile phones acknowledged potential using improve healthcare services adoption acceptance technology among elderly significantly low however little research done draw systematic study intention adopt services objective aim study develop theoretical model based unified theory acceptance use technology empirically test determining key factors influencing elderly users intention adopt use services methods face face structured questionnaire survey method used collect data nearly participants age years capital city data analyzed using partial least squares method statistical analysis technique based upon structural equation modeling sem results study determined performance expectancy effort expectancy social influence technology anxiety resistance change conclusions study confirms applicability model context services among elderly developing countries like provides valuable information service providers policy makers understanding adoption challenges issues also provides practical guidance successful implementation services additionally empirical findings identify implications related design development services influence potential users furthermore due generic approach findings study easily modified assist developing countries planning take services elsevier rights reserved
background objective study determine influence loading frequency failure articular cartilage bone specimens three point bending methods study cyclic three point bending used introduce failure cartilage bone specimens varying loading frequencies varying maximum compressive loads range applied beam shaped cartilage bone specimens frequencies results number cycles failure decreased loading frequency increased normal gait impulsive loading frequencies found specimens reached run loading cycles frequencies respectively however specimens reached run loading frequencies conclusion results indicate increasing loading frequency reduces ability specimens resist fracture bending findings underline importance loading frequency concerning failure articular cartilage bone implications early onset osteoarthritis
context partner services hiv sexually transmitted diseases public health intervention activity recommended centers disease control prevention includes counseling partner linkage care referral services objective time study partner services case investigations documented differences times process hiv sexually transmitted disease cases setting cases local regional sites new york participants fifty two partner services disease investigators documented randomly selected cases infections hiv cases assigned june september cases unit analysis represented partner services investigations design cases selected via stratified random sampling infections assigned staff case disease investigators completed standard time study form document time spent specific tasks outcomes tests continuous variables chi tests categorical variables assessed variation outcomes across infection type main outcome measures outcomes included minutes spent specific tasks medical provider index case outreach travel partner days case remained open disposition codes number partners reached results case processing times varied hiv tasks taking minutes cases open days partners cases overall time median spent index cases median partner wide range across cases conclusions given chronic resource constraints public health agencies identify efficient methods allocate resources including infections prioritize documenting workers allocate time across cases essential improving effectiveness efficiency program generating data model return investment
january december one famous female century life work set new standards playing however career poor health two world lifetime three major disorders juvenile requiring treatment adolescence tumor region requiring surgery age years traumatic brain injury causing death age medical history illustrates development surgical methods rehabilitation medicine world war early age spent year nursing home orthopedic diseases due years old displayed first symptoms brain tumor headache famous surgeon performed surgery without general anesthesia mentally played neuronal representation control memory mental abilities months operation played began career great neurologic rehabilitation remarkable highlighted new methods field train station hit head one steps skull fracture intracranial diagnosed doctors tried operate lost consciousness died created new styles playing medical history offers indications new concepts
isolation high quality rna plant tissues one critical steps successful application diagnostic tests reverse transcription polymerase chain reaction pcr northern blotting microarray hybridization presence inhibitors secondary metabolites phenolic compounds cause inaccurate undesirable results rich wide range metabolites interfere rna isolation point view researched six different total rna extraction methods leaves find best one contribute purity high quality methods tested silica capture modified silica capture commercial kit new combined lithium chloride buffer rna quality gel electrophoresis pcr result clear suitable isolation protocol new combined method experienced named firstly terms rna purity concentration less time consuming isolation step achievement detection
particles natural photocatalyst configured packed bed photocatalytic reactor studied wastewater pollutants solar light photocatalytic system equipped cylindrical parabolic sunlight photocatalytic treatment developed continuous flow wastewater sunlight irradiation influence incident radiation amount photocatalyst several configurations hydrodynamics studied moreover results obtained compared obtained adsorption studies good photocatalytic activities observed allows heterogeneous photocatalytic system packed bed effective method wastewater pollutants removal day contaminant removed continuous flow photocatalytic treatment wastewater packed bed reactor sunlight possibility combining renewable energy solar energy photocatalytic technology means sustainable photocatalytic material offers powerful alternative wastewater treatment sector
liver pancreas critical organs maintaining whole body metabolism historically expansion adult derived cells organs vitro proven challenging turn hampered studies liver pancreas stem cell biology disease modelling cell replacement therapies pathologies organs recently defined culture conditions described allow vitro culture manipulation adult derived liver pancreatic material review systems assess physiological relevance potential utility elsevier inc rights reserved
health care services show epidemiological changes increase number consultations due mental causes violence without necessary capacity respond increasing demand objective analyze compare demand hospitalization due psychosocial causes pediatric hospital three different periods materials methods descriptive retrospective study cases children adolescents hospitalized psychosocial causes hospital data processed using frequency analysis chi square test results records analyzed hospitalization rate year hospitalization rate psychosocial causes increased years common reasons admission suspected child abuse suicidal behavior suspected sexual abuse substance abuse episode psychotic episode showed prevalence episode psychotic episode suicidal behavior suspected sexual abuse common women episode substance abuse common men conclusions hospitalizations psychosocial causes particularly mental causes children adolescents increased show different behavior according age gender health problems related violence frequent ones
interest systematic study circadian typology relatively recent developed rapidly two last decades existing data suggest individual difference affects biological psychological functioning health also disease present study review current literature concerning psychometric properties validity measures individual environmental genetic factors influence present brief overview biological markers used define differences groups sleep wake cycle body temperature cortisol melatonin assess implications adjustment jet lag also review differences terms cognitive abilities personality traits incidence psychiatric disorders necessary emphasized methodological limitations exist today suggested future avenues work order overcome new field interest professionals many different areas research labor academic clinical review provides state art discussion allow professionals integrate aspects human behavior daily practice
open loop unstable systems time delays often encountered process industry often difficult control stable processes paper stabilization pid controller second order unstable processes represented second order unstable pole second order two unstable poles performed via necessary sufficient criteria stability analysis stability analysis provides improved understanding existence stabilizing range pid parameter three simple pid tuning algorithms proposed provide desired closed loop performance robustness within stable regions controller parameters obtained via stability analysis proposed pid controllers show improved performance derived via existing methods published elsevier ltd behalf
causal attributions mental health problems play crucial role shaping differentiating illness experience different sociocultural ethnic groups aims study analyze older causal attributions mental health problems examine associations demographic diagnostic characteristics proxy indicators causal attributions analyze connections causal attributions manifestation somatic affective cognitive depressive symptoms sample aged years living finland asked list top three causes mental health problems depressive symptoms analyzed using beck depression inventory bdi results showed commonly endorsed causal attributions mental health problems related relationships various life problems identified five attribution categories somatic interpersonal psychological life experiences religious causes common causal attribution categories life experiences interpersonal causes mental health problems men tended attribute mental health problems somatic psychological causes women interpersonal religious causes age proxy indicators associated causal attributions participants psychiatric diagnosis treatment history reported somatic psychological attributions participants finally attributed mental health problems life experiences war reported marginally fewer cognitive depressive symptoms guilt results discussed relation biomedical models mental health service use immigration experiences culturally relevant patterns symptom manifestation
solving large scale sparse linear systems plays key role fluid mechanics simulation design materials petroleum seismic data processing numerical weather prediction computational numerical simulation unclear therefore developing algorithms issue significant research topic paper proposed hyper scale custom architecture matches specific data features process key procedure block algorithm parallel algorithm custom machine increase computation communication storage performance four optimization strategies proposed paper builds performance model evaluate execution performance power consumption custom machine model shows optimization strategies result considerable speedup even three times faster fastest consuming less power
recent advances basic medical sciences particularly cell biology genomics great promise future development aspects practice also hitherto neglected fields including involving care rapidly increasing number elderly patients complex problems practice developing countries obtain maximum benefit new developments necessary review patterns training future every level short important try design develop various career pathways training including wish work full time basic research combine research clinical practice time clinical work teaching
study question ulipristal acetate upa effect beat frequency muscular contractions human tube summary answer upa inhibits beat muscular contraction human tube probably effect progesterone receptor known already upa like acts emergency contraceptive mainly inhibiting ovulation little known effects function study design size duration vitro experimental study using tube samples collected women undergoing benign non conditions participants materials setting methods epithelium longitudinal smooth muscle fibres isolated cultured treated upa graded concentrations graded concentrations respectively treatment beat frequency determined using method basal tone amplitude frequency muscular contraction recorded force transducer mrna expression progesterone receptor total isoform determined real time quantitative pcr main results role chance overall dose dependent suppressive effect beat frequency treatment upa concentrations basal tone amplitude frequency muscular contractions significantly reduced treatment upa upa treatment significantly regulated mrna expression progesterone receptor regulated mrna expression tube tissue limitations reasons caution whether effect translate additional mechanisms contraceptive action vivo uncertain wider implications findings clinical relevance upa regard contraceptive activity exploration study funding competing interest study supported seed centre reproduction development growth faculty medicine university hong kong authors competing interest
functional factors responsible bearing groundwater used drinking cooking area sub basin district india discussed study area part complex consisting occur chemistry groundwater dominated higher results higher total total hardness causing excess sodium ion dominated among concentration higher desirable national limit prescribed drinking purpose significant positive correlation exists indicates alkaline condition prime conducive factor bearing minerals effectively leading higher concentration groundwater furthermore positive alkaline index reflects ion exchange respect indicates evaporation addition negative relation depth shows effect solubility different depth levels factors regulate concentration groundwater hand positive correlation shows human land use activities namely use chemical disposal domestic wastes etc add groundwater significant number residents study area suffer health disorders related consequence higher concentration drinking water thus study emphasizes need supply safe drinking water nutritional diet rainwater harvesting structures public education realize health world health organization
variation among existing studies labeling defining identifying cases suspected drug facilitated sexual assault poses challenges integrating research findings public health purposes descriptive study addressed methodological issues operational definitions improve case identification designed distinguish assault subtypes studied year diverse cohort patients presented acutely urban treatment center abstracted data medical mental health records via chart review assault incidence rates engagement medical forensic mental health services injury sustained use calculated separately assault subtypes compared accounted half total sexual assault cases substance administered victims without knowledge increased cases year period victims presented often attended medical follow psychotherapy non victims incidence rates indicated increasing risk young males findings indicate continues growing complex phenomenon suggest victims greater service needs field benefit innovations address symptomatology arising novel type trauma unique risks needs male victims ongoing need specific prevention efforts victims perpetrators
current applications complex sensor systems quantified self online markets acquire vast quantities personal information usually end central servers exposed eyes conversely decentralized architectures help individuals keep full control data global treatments queries development innovative services article aims precisely individuals privacy one side global benefits community business perspectives promotes idea security secure hardware devices controlling data place acquisition thanks tangible physical elements trust secure distributed querying protocols capacity perform global computations structured query language sql aggregates without revealing sensitive information central servers article studies secure execution queries presence malicious attackers also discusses resulting querying protocols integrated concrete decentralized architecture cost models experiments sql asymmetric architecture distributed prototype running real resistant hardware demonstrate approach scale nationwide applications
nadph involved inflammation angiogenesis tumor growth osteoclast differentiation however role macrophage differentiation tumor progression still elusive report critical differentiation monocytes macrophages polarization type type macrophages occurrence tumor associated macrophages found deletion led dramatic decrease ros production macrophages resulted impaired efficiency monocyte macrophage differentiation type macrophage polarization showed critical activation erk macrophage differentiation deficiency erk activation responsible failure monocyte macrophage differentiation turn affecting macrophage polarization furthermore demonstrated decrease macrophages concomitant reduction cytokine chemokine secretion contributed delay wound healing inhibition tumor growth metastasis double knockout mice compared mice collectively data provide direct evidence deficiency impairs macrophage differentiation occurrence type tumor development
molecular mechanisms governing maintenance commitment differentiation stem cells largely molecules involved regulation multiple cellular processes particular importance stem cell physiology integrate different signals coordinate cellular decisions related self renewal fate determination emerged critical factor dna replication stem cell differentiation different stem cell populations inhibitory interaction member complex ensures controlled timing dna replication consequently genomic stability actively proliferating cells embryonic somatic stem cells shown interact transcription factors epigenetic regulators drive gene expression programs ultimately guide cell fate decisions ever growing number studies suggests interactions proteins regulating transcription conserved among interactions proteins modifying members group proteins permissive long established complexity interactions however just beginning unravel revealing key roles maintaining stem cell self renewal fate specification review summarize current knowledge give new perspectives role transcriptional epigenetic regulation alongside regulatory activity dna replication implication regulation stem progenitor cell biology
common way learn studying written step step worked examples however computer programming tedious create since static text based format convey happens code created system called enables people easily create visual coding steps automatically generated program visualization using developed novel workflow learners visiting educational website collectively create tutorial execution steps piece code voting best annotations since far learners experts using learners potentially scalable way creating experiments expert learners adding raw annotations two pieces python code show learner annotations accurate informative containing insights even experts missed
hypothesized epithelial cells small intestine display colonic phenotype total aims present study identify preferentially expressed molecules colon small intestine evaluate mrna levels differential gene expression investigated small intestine colon using cdna microarray confirmed northern blotting expression three colonic mrnas hydroxy synthase malignant brain tumors antigen related cell adhesion molecule one small intestinal triglyceride transfer protein mrna compared control quantitative reverse transcriptase polymerase chain reaction seventy four clones differentially expressed difference differential expression confirmed mrnas examined including hydroxy synthase triglyceride transfer protein mucosal expression antigen related cell adhesion molecule mrna enhanced humans develops colonic phenotype total comparative study epithelial gene expression small intestine colon enables analyze mechanisms intestinal adaptation total
feature weighting vital step machine learning tasks used approximate optimal degree influence individual features salience feature changed different queries majority existing methods sensitive enough describe effectiveness features suggest dynamic weights dynamically sensitive effectiveness features order achieve propose feature weighting function dynamically proper weights feature based distinct feature values query instance proposed weighting function extension previous work suitable single modal multi modal weighting problems hence referred general weighting function number parameters proposed weighting function fewer compared ordinary weighting methods show performance general weighting function proposed classification algorithm based notion dynamic weights optimized one nearest neighbor algorithm experimental results show proposed method outperforms ordinary feature weighting methods elsevier ltd rights reserved
purpose purpose review provide update clinical public health economic consequences leading bacterial cause food related illness importance enhanced chronic sequelae result acute infection recent advances include new clinical classification system neurological sequelae aim accurate diagnosis appropriate treatment better understanding mechanisms underlying functional gastrointestinal disorders emergence potential agents inflammatory bowel disease new mechanism antimicrobial resistance better appreciation economic infection common lead serious chronic sequelae considerable personal healthcare societal costs
background bone protein signalling emerged fundamental pathway endothelial cell biology pathway implicated several vascular disorders signalling output endothelial cells highly context dose dependent phosphorylation intracellular effectors routinely used monitor signalling activity better understand vivo context dependency signalling investigated differences transcriptional activity different vascular beds mouse embryonic postnatal stages used gfp signalling reporter mouse response element target gene drives expression gfp results mosaic pattern gfp present various angiogenic cardiac heart high veins seemed gfp active arteries ubiquitous activity present embryonic vasculature postnatal vessels showed however discrete micro domains transcriptional activity dynamic shifts transcriptional activity also observed developing heart general decrease activity time surprisingly proliferative endothelial cells almost never gfp positive patches transcriptional activity seemed correlate vasculature undergoing hemodynamic alterations conclusion gfp mouse allows investigate selective context dependent aspects signalling data reveals highly dynamic nature mediated transcriptional regulation time space throughout vascular tree supporting signalling source phenotypic diversity healthy endothelium knowledge provide insight vascular bed organ specific diseases phenotypic heterogeneity within endothelial cell population
transfer mass drop liquid flow zero numbers theoretically studied allow external flow small zero amount inertia problem governed three dimensionless parameters capillary number viscosity ratio lambda external reynolds number shown shape drop first approximation spindle suggesting usage coordinate system applying method presented electrostatic capacity spindle analytical solution containing functions obtained results show capillary number reynolds number increase drop becomes thinner longer surface area increases resulting larger mass transfer rates capillary number influential parameter elsevier rights reserved
immune response determined speed cell reaction antigens state readiness proliferation cytokine secretion proliferation apoptosis motion many cell types controlled cytoplasmic proteases inhibitor together forming system assumed modify targets upon activation dependent cytoplasmic increase notion using quantitative real time pcr flow cytometry respectively show genes constitutively expressed constitutively active resting circulating human lymphocytes furthermore demonstrate inhibition resting cells prevents proliferation vitro greatly reduces secretion multiple cytokines mechanistic reason effects inhibition cell functions demonstrated significant reduction expression active phosphorylated upstream signalling molecules including phospholipase gamma kappa inhibitor treated cells thus propose constitutive self regulatory system activity resting human cells necessary controlling element readiness complex effective response antigenic challenge
global navigation satellite systems like gps also represent important infrastructure society provide position timing numerous applications rather complex system consisting around satellites number monitor stations plus control center receivers represent user segment receivers monitor stations receive weak satellite radio signal thus susceptible interference like paper outlines core operation principles satellite navigation describe kind interference analyze impacts different types interference attacks result different effects target receiver attack schemes categorized within paper reported incidents summarized potential impact vulnerability critical infrastructure known countermeasures user receiver level system level outlined discussed suitability political socioeconomic context vulnerability described emphasizing large impact potential disruption service
work attempts experimental studies finite element model updating actual rotor system mounted ball bearings using inverse sensitivity method applied state space representation equations motion used identify bearing stiffness damping shaft material damping parameters non proportional viscous damping model used model bearing shaft material damping experimental identification viscous coefficient shaft material damping found available literature work attempts updated model validated accuracy comparing predicted frequency response obtained experiments finally shown updated finite element model rotor system efficiently used predict rotor elsevier ltd rights reserved
twenty three percent heart failure patients memory loss objectives characterize major allelic frequency variants apolipoprotein apoe gene patients evaluate differences memory serum brain derived neurotrophic factor bdnf levels based apoe epsilon allele estimate effect sizes confidence intervals cis pilot patients enrolled completed recall delayed recall memory measured baseline weeks serum collected baseline weeks seven patients apoe epsilon allele significant differences found recall delayed recall memory serum bdnf levels based apoe epsilon allele small medium cis indicated precision small future studies needed fully understand genotypic neuropsychological phenotypic variables influence response computerized cognitive training
water important element life water pollution common threat concerning public health pakistan order check groundwater quality drinking purpose research conducted town industrial area district area divided four zones sampling groundwater quality evaluation sixty water samples existing sources along coordinates four soil samples taken understand mobility behavior contaminants drain passing research area expected main source soil groundwater contamination therefore sampling points drinking water samples selected keeping consideration relative position drain collected samples analyzed chemical parameters results obtained samples compared guidelines values results represented mapping quality parameters using gis used interpolation long term trends groundwater quality parameters revealed increasing effect contamination respect time soil analysis study area showed sandy soil texture overall consequently showing high rates infiltration soil concluded water partially fit drinking specifically due increased concentration hardness direct use groundwater drinking purpose cause health issues gastrointestinal illness nausea eye nose irritation etc
purpose review examines utility stem cell biology applicability stem cell biology varies across range different within surgery resident stem cells identified gland corneal orbital fat muscles eye potentially applied vitro cell organ cultures intent disease modeling discovery derived stem cells offered potentially powerful tool variety applications wound healing skin burn therapeutics several groups currently identifying new uses stem cells need stem cell treatment spans wide array within ranging reconstruction generation artificial glands therapeutics advent induced pluripotent stem cells opened regenerative medicine making modeling patient specific diseases possibility identification characterization endogenous stem cell populations eye makes possible obtain specific tissues induced pluripotent stem cells differentiation use surgery
purpose identify incidence risk factors recurrence discontinuation successful antimuscarinic therapy patients overactive bladder oab materials methods prospective multicenter trial patients antimuscarinic agents weeks showed successful response enrolled successful response defined answering benefit patient perception treatment benefit answer lesser points patients perception bladder condition enrolled patients discontinued evaluated recurrence oab symptom score months primary purpose identify recurrence rate secondary purpose reveal risk factors results four hundred forty one patients enrolled patients completed month follow enrolled patients showed points points points quality life represented successful response using cumulative rates recurrence months respectively among patients show recurrence months patients followed patients patients showed recurrence months univariate multivariate analyses recurrence oab wet risk factor recurrence months discontinuation conclusions discontinuation antimuscarinic therapy successful treatment resulted high recurrence rate time oab wet independent risk factor recurrence
last years greater interest using computers education particular engineering education software programs great impact studying many physical phenomena otherwise described using complex mathematical algorithms furthermore computer simulation studied behavior many engineering systems production however focus many times exclusively future engineers different perspective lack real measurement future data manipulation interpretation time experimental stands often expensive many university laboratories article author presents methodology compromise use software dedicated programs really electrical systems use electronic simulators releases university laboratory expensive put large gap practice theoretical concepts based block system diagram real system constructed electronic simulator using basic operational amplifier structures circuits result electronic system simulator
improved monte carlo method standard less analysis laser induced breakdown spectroscopy presented concentrations found fitting model generated synthetic spectra experimental spectra current version based graphic processing unit gpu computation reduces analysis time several seconds per spectrum sample previous version based central processing unit cpu computation requested long analysis times minutes per spectrum sample reduction computational time achieved massively parallel computing gpu thousands processors shown number iterations gpu exceeds cpu factor parameter space yet requires fold shorter computational time improved gpu outperforms cpu terms accuracy precision analysis time performance tested spectra obtained metal oxides consisting simulated products steel industry steel demonstrated gpu based capable rapid multi element analysis relative error percent sufficient industrial applications steel analysis results improved gpu based positively compared cpu based results standard calibration free based boltzmann plot method elsevier rights reserved
work presents applications inductive topological approach calculation transfer function network control system method provides versatile effective way counting graphs contribute translating algebraic contribution contributing graphs simple reflect morphology original control system signal flow graph application method results presented cell network derive analytical formula relating omega filter size broken vertical bar formula used designing frequency range self loaded filters varying size also derive general expressions sensitivities use observe sensitivity filter transition various frequency ranges relaxation times importantly filter sizes
new type mechanically earth structure composed geosynthetic tubes filled expanded clay lightweight aggregate geosynthetic reinforcement introduced results study demonstrate alternative solutions expanded clay lightweight aggregates used interaction geosynthetics comparison classical soil new type geosynthetic tubes filled dynamically expanded clay lightweight aggregate tested situ compressive loading geosynthetic tube instrumented load cell transducers characteristic cross section obtained three dimensional scanner measurements loading next simplified engineering formulation geosynthetic tubes compressive loading evaluated including influence volume variation tube based classical approach soil mechanics produces required design tensile force tube dependent geosynthetic stiffness experimental results compressive loading tests compared analytical equations results discussed show influence geosynthetic stiffness behaviour tube terms loading capacity volume variation cross section tube agreement theoretical analyses experimental results reasonably good formally accepted given volume variation geosynthetic tube
nucleus recently shown encode reward studies performed humans investigated encoding reward loss valence humans parkinsons disease test hypothesis neurons change firing rate response reward loss related stimuli recorded activity individual neurons participants performed behavioral task task action choices associated potential neutral outcomes found neurons encode valence related information action control proportion valence responsive neurons greater compared reward related stimuli greater proportion neurons loss related stimuli also found surprising limbic overlap sensorimotor regions overlap greater previously reported findings help explain alterations limbic function observed following deep brain stimulation therapy wiley periodicals inc
following locus specific genome editing mouse embryonic stem cells identification correctly targeted clones remains challenge applied multiplex ligation dependent probe amplification screen homologous recombination based genomic integration knockout construct part gene candidate thereby identified subsequently validated conventional methods thus represents highly reliable cost time efficient alternative currently applied methods southern blotting polymerase chain reaction pcr based approaches also applicable recombination strategies compatible system genome editing strategies elsevier inc rights reserved
article critically discusses contemporary danish policies aimed elimination discrimination drawing policy analyses qualitative interviews local national authorities denmark illustrates questions discrimination racism within dominant integration discourse resulting anti racism side stepping racism public policies strategies denial addressing discrimination product individual prejudice rather embedded social structures authors examine immigration integration anti racism concepts phenomena understood addressed danish public policies discourses despite racism denmark show based definitions identities relations continues exist evident public debates policies immigration integration
paper explores large signal small signal dynamics series capacitor buck type converter introduces optimal closed loop control scheme accommodate steady state transient modes opposed conventional buck converter time optimal control realized single cycle buck topology need distribute switching phases satisfy charge balance capacitor new control method hybrids voltage mode small signal controller steady state operation non linear state plane based transient mode control scheme load transients detailed principle operation buck converter provided explained average behavioral model state plane analysis operation controller experimentally verified converter demonstrating voltage mode control operation time optimal response load transients
solving resource constrained project scheduling problems one important tasks project planning process study presents new hybrid approach named artificial colony differential evolution handle resource constrained problems proposed algorithm integrates crossover operations differential evolution original artificial colony abc balance exploration exploitation phases optimization process furthermore study applies serial method reflect individual vector priorities active schedule calculate project duration algorithm compared benchmark algorithms considered using real construction case study set standard problem available literature experimental results demonstrate efficiency effectiveness proposed model promising alternative approach handling resource constrained project scheduling problems
important species aquaculture common wild study course infection bacterium conducted using different challenge methods fresh water bacterial isolation elisa pcr tests used detection bacterium multiple organ samples experiment run water infection established intraperitoneal injection colony forming units cfu fish external internal symptoms bacterial kidney disease injection trial run simultaneously infection established demonstrated detection methods applied symptoms seen survived separate experiment infection established pumping fixed amount water tank infected intraperitoneal injection tanks naive fish fresh water fish inflow tanks additional neither macroscopic symptoms elisa pcr tests showed infection started take hold challenge trials demonstrated susceptible inflow water tanks infected fish provide useful models studies infection acquired natural way
introduction nurse patient communication highly important especially patient child one overlooked nursing profession less discussed communicate children design training courses development communication skills considered important step direction study investigated effect training communication skills childrens nurses role playing materials methods study clinical trial pre test post test done nurses hospital iran nurses randomly assigned either intervention control groups nurses communication skills measured using tools communication skills assessment three weeks intervention one day workshops hours teaching communication skills children given nurses role playing based pre prepared scenarios results results showed significant difference two groups mean score nurses verbal non verbal communication skills intervention verbal non verbal intervention mean score nurses verbal nonverbal communication skills experimental group statistically significant higher control group conclusion now due weakness relationship nurse child nurses also receive instruction communication specific skills related children seems essential effect implementation various educational practices examined nurses communication skills
current study examined parent heart rate dynamic changing patterns links observed negative parenting emotional psychological control parent child conflict resolution task among parent child dyads child age ranged years age parent obtained ecg data collected parent child conflict resolution task negative parenting coded offline based video recording task results revealed emotionally sensitive parents task showed greater increases discussing conflict greater decreases resolving conflict whereas emotionally unavailable parents showed changes however parent psychological control associated dynamics task findings indicated physiological underpinnings parent emotional sensitivity responsiveness parent child interactions potential association baseline levels parenting behaviors also discussed
women less likely men engage sexually behavior initiating sexual encounters despite benefits associated sexual agency two studies examined possible explanations related person perception gender differences sexually behavior study participants viewed dating profiles targets either high low sexual agency rated sexually targets desirable also sexual partners previous sexual partners partners overall participants believed female targets desirable also highest number previous sexual partners study female participants importance consequences sexual agency differently male participants based two studies suggest although men women judged similarly sexual agency women sexual agency view traits characteristics perceived hand hand sexual agency negatively
software integration testing plays increasingly important role software industry experienced major change isolated applications highly distributed computing environments conducting integration testing challenging task often difficult replicate real enterprise environment testing environment one key solutions problem however existing specification based techniques require manual coding message processing engines therefore high development cost paper present suite domain specific visual modeling languages describe testing environments high abstraction level solution allows domain experts model testing environment abstract interface layers layer models transformed runtime environment application testing user study shows visual languages easy use yet sufficient expressive power model complex testing applications
although young adult women consume majority total daily energy intake home food sources decision making processes shape home food environments received limited attention decision making affected experience unknown study explore factors influence two key decision making processes food choices use non home food sources whether differences status depth interviews conducted women aged living southwest thematic analysis used analyze qualitative data stratified whether children present home decision making affected numerous factors differed across groups regard women children frequently discussed influence nutrition preferences children women without children frequently discussed influence taste preferences household members cost convenience weight control pre planning meals emerged salient groups regard use non home food sources convenience taste discussed groups social factors discussed women without children cost eating reason cited eating inside home factor emerged among women children important contributor decision making processes shape young adult womens home food environments interventions find success framing messaging emphasize factors identified motivating healthy decisions protecting health children practical strategies adapted already use pre planning healthy meals elsevier ltd rights reserved
background elevated blood pressure one main risk factors death globally behavioral training complementary approach blood pressure stress management intended exercise autonomic improve stress recovery lower blood pressure involves cognitive behavioral therapy breathing technique heart rate variability limited clinic delivery faces accessibility barrier need clinical use complex monitoring tools objective objective project design develop evaluate wearable ecg sensor system delivery home setting methods wearable sensor system beat consists ecg sensor mobile app developed iteratively using principles test driven agile development user centered design usability study conducted general hospital evaluate feasibility user experience identify areas improvement results beat sensor designed modular patch users chest uses standard ecg electrodes streams single lead ecg mobile phone using low energy use small low power electronics low device profile allowed device sensor designed operate mobile app guides users exercises train slow breathing technique stress recovery app uses ecg captured sensor provide heart rate variability form real time heart rate waveform complement reinforce impact training usability testing indicated overall response design user experience system perceived positively participants indicated system positive effect stress management use home areas improvement identified focused primarily delivery training education app conclusions outcome project wearable sensor system deliver home system potential offer complementary approach blood pressure stress management home reduce current accessibility barriers
background aim long term success rehabilitation chronic low back pain yet established present study examined promoting factors barriers barrier management health promoting behavior among patients method total documents patients inpatient behavioral medicine orthopedic rehabilitation clinics included analysis written survey based open questions free statements electronically recorded analyzed content analysis results promoting factors patients implementation healthy life style behaviors included learning techniques pain stress management increased quality life among patients increased depressive symptoms insufficient family professional pressures identified barriers finally social support reported facilitate implementing health promoting behavior daily life conclusions results suggest long term rehabilitation success improved treating exercises implement health promoting behavior daily life applying individualized barrier management offering post treatments communities
study examines utility accurate diagnoses context diagnostic decision making mental disorders study also aimed replicate results meta analysis indicating association patients gender end asked judge three case describing patients major depressive disorder mdd generalized anxiety disorder borderline personality disorder therapists randomly assigned experimental conditions diagnostic method using diagnostic without using diagnostic gender male female case subjects design multinomial logistic linear regression analyses used examine association usage diagnostic patients gender diagnostic decisions results showed used fewer incorrect morbid diagnoses made clinicians less likely diagnose mdd even criteria met additionally improved therapists confidence diagnostic decisions associated estimations patients characteristics expected significant associations gender diagnostic decisions
purpose trajectory health related quality life hrqol children aged years relationship speech language difficulties examined using data longitudinal study australian children method generalized linear latent mixed modelling used analyse data three waves across four hrqol domains physical emotional social school functioning four domains hrqol measured using paediatric quality life inventory examined find contribution accounting child specific factors gender ethnicity temperament family characteristics social ecological considerations psychosocial stressors result multivariable analyses one measure namely parent concern receptive language negatively associated hrqol domains covariates positively associated hrqol domains included childs general health maternal mental health parental warmth primary caregivers engagement labour force conclusion findings suggest associated reduced hrqol study children typical speech language skills protective factor positively associated hrqol
biomolecules known heavy metals wastewater cellulose example however less used natural molecules also efficient heavy metals indeed cells contain help living organisms containing heavy metals natural detoxification process great interest particularly molecules taking part amino acids especially cysteine tyrosine used water purification efficiency biomolecules containing aromatic rings heavy metals also investigated biomolecules able heavy metals thanks chemical groups atoms known efficient chemical groups listed article finally potential environmental applications biomolecules suggested end article
purpose leadership significant success factor promoting sustainability practices construction industry sustainability integral part construction industry affects aspects construction business operations purpose paper investigate particular leadership style associated intra organizational leaders within construction organizations charged promotion sustainability practices paper therefore examines effective leadership style sustainability professionals responsible developing sustainable construction strategies design methodology approach qualitative data collected semi structured interview leaders followed industry wide survey intra organizational leaders contractor organizations construction industry findings results showed one best leadership style situation leaders charged role promoting sustainable construction strategic style behaviour originality value although leadership sustainability widely covered separate issues little rigorous research done link leadership sustainability construction management research findings guide organizational leaders responsibility promoting sustainability practices
pressure overload shown induce mitogen activated protein kinases atrial factor heart test sensitivity signals pressure overload assayed activity extracellular signal regulated kinase jun terminal kinase protein left ventricle white blood cells isolated aortic mice varying levels pressure overload separated mice measured atrial factor mrna levels northern blotting expected significant induction atrial factor mrna levels observed aortic significantly correlated trans systolic pressure gradient weight body weight ratio contrast significant correlation systolic pressure gradient weight body weight ratio observed mapk activity detected samples importantly activation significantly correlated activation animal test whether mapk activation reflect uncontrolled blood pressure levels humans assayed extracellular signal regulated kinase jun terminal kinase activation isolated volunteers hypertensive patients controlled blood pressure values hypertensive patients uncontrolled blood pressure values interestingly hypertensive patients controlled blood pressure values mass extracellular signal regulated kinase phosphorylation significantly reduced compared hypertensive patients uncontrolled blood pressure values results suggest sensors pressure overload extracellular signal regulated kinase activation used novel surrogate biomarker uncontrolled human hypertension hypertension
present study tested greater levels couple identity increase womans coping self efficacy relation breast cancer turn predicts better psychosocial adjustment women committed relationships completed surveys assessing levels couple identity cancer coping self efficacy aspects psychosocial adjustment specifically depression anxiety functional one outpatient visits cancer centre predicted women identified relationships lower levels depression anxiety greater functional relationship mediated coping self efficacy greater identification ones relationship predicted greater confidence ones ability cope turn predicted better adjustment role intimate relationships play womens adjustment breast cancer directions research discussed
purpose studied sexual reproductive health among self identified bisexual lesbian heterosexual adolescent young women prior research suggested bisexual lesbian young women greater risk many negative health outcomes including risky sexual reproductive health behavior methods using data nationally representative national survey family growth examined sexual reproductive health among young women years age function sexual orientation used logistic regression examine differences sexual reproductive health across groups controlling demographic group differences results bisexual lesbian young women reported elevated sexual reproductive health risks bisexual lesbian participants reported younger heterosexual sexual male female sexual partners heterosexual participants likely heterosexual young women report forced sex male partner bisexual young women reported earliest sexual highest numbers male partners greatest use emergency contraception highest frequency pregnancy termination conclusions overall sexual minority young women especially identified bisexual higher sexual reproductive risk heterosexual peers society adolescent health medicine rights reserved
molecular characterization circulating tumor cells critical identify key drivers cancer metastasis therapeutic approaches particularly inflammatory breast cancer usually diagnosed advance stages progresses rapidly genomic alterations tumor tissue samples studied using foundation one single isolated using followed single cell isolation samples chosen isolate single using genomic alterations studied primary tumor metastatic sites patients genes high frequency mutations follows also least treatment detected patients metastatic two patients locally advanced four patients detectable per blood fifteen patients six chosen random isolate single cells tested presence mutations previously found matching tissue biopsies isolated showed mutations primary metastatic tumor samples intra patient heterogeneity found presence different harboring different combinations mutated wild type genes results indicate represent non invasive source cancer cells determine genetic markers disease progresses identify potential therapeutic targets patients
background observational studies used measure effectiveness intervention non experimental real world scenarios population level recognised important component evidence data prospective cohort studies patient registry proven method type study national hepatitis hcv registry established ireland aim monitoring clinical economic outcomes new high cost regimens treatment hcv infection sustained virological response weeks following completion therapy interferon containing regimens considered cure non studies result confounding selection bias propensity score matching one number statistical tools used mitigate effects confounding observational studies methods analysed data patients underwent triple therapy treatment combination interferon ribavirin june december decision initiate treatment selection treatment regimen physician adjust confounding three approaches propensity score matching assessed adjusted sustained virological response rates odds ratios values confidence intervals calculated three matched dataset results prior matching unadjusted sustained virological response rates weeks treatment complete respectively matching adjusted rates respectively conclusion efficacy rates comparable reported pivotal clinical trials real world studies adjusting confounding conclude difference treatment effect matching small sample size limits conclusions made effect matching propensity score adjustment remains tool applied future analysis however suggest possible using larger sample size order reduce uncertainty around outcomes
gene encodes cyclin like protein implicated phosphate environment better understand regulatory role gene product differential display reverse transcriptase polymerase chain reaction used isolate transcripts differentially expressed mutant strain grown phosphate two transcripts whose differential expressions confirmed northern blotting downregulated strain carrying loss function mutation gene allele transcripts revealed genes coding enzymes involved pathway iso biosynthesis methyltransferase relevant understanding molecular events involved phosphorus sensing
purpose two randomized intra individual comparison studies performed healthy subjects evaluate skin barrier restoration potential new topical containing study effect skin study methods study two skin areas one challenged sodium sulfate sds solution one treated weeks water loss skin hydration intercellular lipid organization measured regular intervals study study quantitative bacterial cultures obtained skin area undergoing stress sds subsequent single application results study mean auc reduction baseline pronounced compared control use also associated statistically significant improvements stratum hydration increase mean length baseline day study use negative impact bacterial viability conclusions use favorable lasting effects barrier function repair skin hydration without negatively influencing bacterial viability
quality function deployment model optimal decision making model applied design special shaped stone machining center establishment design house quality machining center convert users needs requirements improvement machining center engineering measures shape design machining center manufacturing engineering time combine resource consumption various engineering measures implemented resources enterprises together limited resource order make design machining center meet customers needs maximum extent enhance competitiveness machine tool market optimal decision model used select vital engineering measurement designing machining tool
mechanism early recurrence hepatocellular carcinoma hcc understood examine whether early metastasis hcc determined reliable molecular characteristics primary hcc focused early stage tumors primary solitary hcc cases proteomic differences investigated two groups early recurrence within months late recurrence within months hcc cases using two dimensional fluorescence difference gel electrophoresis overall upregulated downregulated proteins identified total protein spots detected early recurrent hcc cluster analysis using proteins successfully divided hcc samples exactly two groups multifunctional protein upregulated early recurrence group immunohistochemistry revealed frequent observation positive hcc cells early group tendency positive staining hcc cells adjacent fibrous examine whether two major associated pathways epithelial mesenchymal transition emt integrin signaling activated early recurrence group hcc downstream molecules measured mrna level emt related genes highly positively correlated mrna however cadherin mrna protein downregulated correlation expression phosphorylation akt downregulation associated quantity therefore contribute early hcc recurrence signaling pathways related emt integrin signaling proteomics strictly classified useful characterizing pro metastatic hcc developing new therapeutic target treatment metastasis
gestational diabetes mellitus pregnancy induced complication increased prevalence especially overweight women fatty acid composition tissues reflect dietary fat intake especially essential intake moreover shown profiles blood lipid fractions altered diabetic patients consequently women also distinctive profile objective review compare profiles different blood lipid fractions influence dietary fat intake women pregnancies results show women saturated less polyunsaturated red blood cell membranes pregnant women moreover studies reported women greater energy intake total fat saturated along lower energy intake compared pregnancies clinical trials showed omega levels membranes women restored dietary intervention research required determine whether profiles altered prior diagnosis prevented diet elsevier rights reserved
cutaneous inflammation alters function primary gene expression affected dorsal root ganglia however specific mechanisms injury induced peripheral afferent sensitization behavioral hypersensitivity development fully understood recent studies children suggest potential role growth hormone pain modulation growth hormone modulates homeostasis tissue repair injury affects neonates known determine whether played role modulating sensory neuron function skin inflammation young mice examined behavioral hypersensitivity response properties cutaneous using vivo skin nerve spinal cord preparation results show inflammation skin initiated either postnatal day reduced levels specifically affected skin furthermore pretreatment inflamed mice exogenous reversed mechanical thermal hypersensitivity addition altering function effects mediated upregulation insulin like growth factor receptor modulated transcriptional output neurons vitro vivo afferent selective knockdown inflammation also prevented observed injury induced alterations cutaneous behavioral hypersensitivity similar pretreatment results suggest block inflammation induced sensitization postnatal development leading reduced behaviors possibly suppressing upregulation within
robust precise control piezoelectric actuators quite challenging due existence strong hysteresis nonlinearities paper control strategy proposed based uncertainty disturbance estimator improve performance positioning control piezoelectric actuators compared existing hysteresis inversion based robust control strategies based controller achieve excellent positioning precision without knowledge bound shape hysteresis simulation results presented illustrate effectiveness based controller system dynamics piezoelectric actuator characterized second order linear system preceded symmetric asymmetric generalized input hysteresis model extraordinary capability based controller demonstrated smart material based actuators shape memory alloys sma hysteresis characterized saturated model
objectives induce disease remission early arthritis patients adhere disease modifying drugs first months diagnosis remains unknown patients non aimed identify patients risk non adherence first months treatment methods adult naive early arthritis patients starting synthetic filled items potential adherence predictors baseline adherence measured continuously non adherence defined opening electronically monitored pill items reduced clustered using principal component analysis discriminating items identified latent trait models used multivariable logistic regression model find non adherence predictors results patients agreed participate adherence high declined time principal component analysis led dimensions subsequent latent trait models analyses led dimensions two dimensions associated adherence one dimension associated conclusions information seeking behavior positive expectations course disease associated adherence patients become passive pain risk non adherence practice implications cues identify non adherence intervene implementing shared decision making techniques elsevier ireland ltd rights reserved
athletes higher risk general population eating disorders risk heightened athletes thin build sports including track athletes particularly vulnerable disordered eating transition home college environment adds stress performance pressures high demands sport environment male female athletes develop eating disorders share common characteristics yet experiences quite different part consequence sex eating disorders develop recognized acknowledged treated within culture sports case report describes experiences two track athletes one male one female recruited division track program elite athletes year experiencing urban college environment experiencing eating disorder characterized restrictive eating significant weight loss injury compromised performance sport received treatment multidisciplinary team professionals athletes achieved weight restoration recovery disorder success sport spite similarities striking differences apparent clinical presentation predisposing features onset symptoms entry points treatment interventions received clinical courses treatment sex differences eating disorders present athletes addressed sport environment findings endorse need research inform prevention strategies risk assessment intervention approaches nutrition sports medicine professionals athletic departments
focus study determine conformational structural properties serine serine met biological active molecule investigate preferred molecular mechanics methods utilized determine optimal different angle values backbone side chains found extended backbone shape conformational range stable serine conformation mol energy density functional theory dft used determine optimized geometry modes title values basis sets potential energy distribution data used carry assignment bands addition spectra stable dimer form determined obtained results compared experimental raman spectra solid phase determine presence charge transfer molecular moment natural bond orbital calculations linear alpha first order value analyses investigated molecule carried using dft basis set study aims determine relatively stable conformation antioxidant investigate molecular geometry molecular vibrations hydrogen bonding interactions forms serine elsevier rights reserved
objective propose phylogenetic significance reflex remains unexplained since publication hands free end gesture method among videos healthy term newborns research project education describe sequence clearly showed successive movements reflex report occurrence reflex videos recorded time birth defined moment lies birth infant results selected sequence showed following newborns actions quick extension arms orientation body head eyes towards human person full extension arms spreading fingers face time birth found significant association occurrence reflex placement newborn birth position mothers abdomen discussion quick extension arms started sequence considered reflex controlled neural fear system arm extension followed reflex characteristics amplitude duration stereotype gestures evolutionary process turns physiological behavior case non verbal communicative behavior whose meaning request arms gestures associated reflex orientation body head eyes towards human person gestures intention communicate support hypothesis neural mechanism reaction probably involves fear separation distress systems conclusion paper proposes first time phylogenetic significance reflex behavior nonverbal communication professionals avoid stimulating newborns fear system triggering education teach parents respond newborn infant arms mother talk elsevier inc rights reserved
hiv stigma inhibit uptake hiv testing antiretroviral therapy negatively affect mental health efforts reduce discrimination people living hiv contributed greater acceptance infection female sex workers experience overlapping stigma due work hiv status although poorly understood examined hiv sex work stigma experienced using cluster randomised trial baseline survey analysed data self reporting hiv women recruited sites using driven sampling asked five questions assess experienced stigma related working sex worker questions asked reference hiv among reported form sex work stigma associated sociodemographic sex work characteristics rates sex work stigma higher hiv related stigma example reported compared involvement sex work reported sex work stigma also reported experiencing hiv stigma compared report sex work stigma suggesting effect experience stigma role women appears prevalent hiv stigma hiv stigma attenuates forms social stigma associated disease persist continue pose barriers effective care
labelled food products mandatory consequence development suitable analytical methodologies detect processed foods work two different qpcr assays detect green locked nucleic acid probes tested compared allergen coding sequences amplified cloned different varieties specific primers probes allergen designed according results probe real time pcr appears sensitive specific method reaching effect temperature pressure dna detection also analysed probe based qpcr data showed reduced thermal treatment pressure nevertheless effect observed applicability method studied analysing food products comparison commercial elisa kit elsevier ltd rights reserved
background aim psoriasis accepted systemic disease known associated various disorders including metabolic syndrome high serum uric acid levels also associated components metabolic syndrome study aimed determine serum uric acid levels patients psoriasis association uric acid levels disease activity taking presence metabolic syndrome criteria account since one important factors affect serum uric acid levels materials methods cross sectional study evaluated psoriasis patients healthy individuals matched patients according presence metabolic syndrome evaluated demographic features levels serum uric acid psoriasis area severity index scores presence psoriatic arthritis nail involvement metabolic syndrome criteria patients results serum uric acid levels psoriasis patients significantly higher controls positive correlation scores serum uric acid levels patients conclusion close relationship psoriasis scores suggest monitoring patients psoriasis serum uric acid levels treatment follow
public opinion research repeatedly shown religious people generally report prejudice however previous research exploring general mechanisms relationship mostly relied samples north america studies outside north america number limited forms address indicators studied far religious quest orientation found one negatively related anti gay leaves open question whether mechanisms different forms also found outside north america background research note assesses religious quest orientation self rated religious behavior related prejudice among youth aged study first investigates relationship religious quest orientation anti gay among found even taking account wide range social background religious characteristics religious quest orientation related less prejudice toward
objective active metabolite possessing estrogen like activity produced action intestinal flora soy increasing evidence regarding efficacy relief menopausal symptoms suppression decreased bone mineral density lipid profile improvement producing capacity however seem benefit thus examined relationship status parameters associated lifestyle related diseases women methods cross sectional study conducted among women average age undergone health screening medical center given consent participate study relationship status metabolic parameters assessed results study women producers producers significantly lower triglycerides higher high density lipoprotein cholesterol levels compared producing women showed significantly lower body fat level visceral fat area triglyceride levels pulse wave velocity uric acid levels high sensitivity reactive protein levels addition women showed significantly higher levels high density lipoprotein cholesterol multivariate logistic regression women production significantly associated lower arterial stiffness uric acid levels high ratio acid acid whereas significantly associated lower urinary conclusions status associated favorable metabolic parameters women early phase transitional periods noted declining intrinsic estrogen levels
narratives important component culture play central role transmitting social values little known however brain reader processes narratives receivers response influenced framing appeal values narratives appeal protected values including core personal national religious values particularly effective influencing receivers protected values resist compromise tied identity affective value moral decision making aspects social cognition investigated neural mechanisms underlying reactions protected values narratives fmri scanning presented american chinese iranian participants real life stories corpus million reading stories engaged posterior medial medial prefrontal parietal cortices participants believed appealing protected value signal regions increased compared protected value perceived possibly reflecting intensive iterative search required process material effect strength also varied across groups potentially reflecting cultural differences degree concern protected values
increase non linear loads electrical network voltage waveform quality one used methods correct quality lack use shunt series mixed topologies active power filters mixed filters compensate loads generate voltage harmonics current harmonics economic investment high commercial shunt filters widespread due design modularity cost although non linear load tracking capability limited aim work improve shunt active filter reference tracking designing variable filter output validity proposed design analyzed matlab simulink platform
energy one important categories green building rating systems world green building building meets energy requirements present low energy consumption investment costs without rights generations find needs despite qualified rating system clear system different priorities needs accordingly paper proposes methodology using analytic hierarchy process ahp assessment energy credits studying comparing four common global rating systems british building research establishment environmental assessment method american leadership energy environmental design leed australian green assessment system united order contribute enhancement green rating system results show mandatory optional energy credits considered proposed weights according present future needs green egypt results compared data gathered studies results extracted recent questionnaires elsevier ltd rights reserved
free standing porous bounded van der interactions used monitor manufacturing process glass fiber reinforced composite paper fabricated multi wall carbon nanotubes via spray vacuum filtration morphology pore size distribution characterized scanning electron microscope nitrogen adsorption desorption resistance sensor obtained using four point probe method resistance changes related phase changes resin matrix experimental results show sensor embedded glass epoxy composite indicated relative resistance change manufacturing process addition temperature sensitivity sensor sensor embedded composite also characterized results demonstrate effect resin phase changes resistance changes sensor greater temperature composite manufacturing elsevier ltd rights reserved
previous studies posture parkinsons disease patients focused pathophysiology severe using mainly subjective estimations measures aim study investigate risk factors associated posture effects course posture variations one hundred ninety patients definite prospectively evaluated angles spinal inclination position extension flexion using mechanical computer assisted hand held device patients underwent clinical examination including background data bone mineral density motor function evaluated back pain physical activity data collected self report postural measurements repeated months angle inclination correlated age older age disease onset longer disease duration higher motor posture score presence back pain osteoporosis correlation angle inclination gender disease type side disease onset evaluation posture patients months initial evaluation showed significant deterioration forward bending significantly associated disease duration worsening score right side disease onset presence vertebral fractures lack physical activity older age disease severity duration presence back pain osteoporosis associated postural abnormalities physical activity slow worsening postural abnormalities
aims study looks connection parents substance abuse years old childrens somatic psychological health methods retrospective population based cohort study based finnish health care social welfare registers participants children born finland biological parents children followed injuries somatic illness psychiatric disorders association parents substance abuse living parent estimated using logistic regression findings childrens reasons prevalent mother father substance abuse problem mothers substance abuse increased childrens risk somatic illness psychiatric disorders fathers substance abuse increased risk psychiatric disorders risks even higher parents substance conclusions parents substance abuse cause variety children related unsafe environment long standing stress non adequate responding childs needs multi professional work substance parents children crucial order reduce childrens risks poor health
recent field work lake delta coastal indicates lateral outflow channels islands upstream receiving basin region delta flow transitions confined uniform discharge profile discharge profile hydraulics transition zone controls exerted vegetation topography river discharge fluctuations analyzed work shallow water equations numerically solved two model domains channel island complex full domain domains significant fraction river discharge flows channels islands reaching receiving basin vegetation roughness within delta islands significantly impacts fraction rate lateral outflow channel river discharge fluctuations limited effect due control flow presence vegetation islands tends increase velocities within channel except region upstream significant lateral outflow velocity increases decreasing vegetation roughness due lowered water level reduces flow cross section topography establishes lateral water surface gradient channel islands even low vegetation roughness drives lateral flow velocity spreading angle used mark transition confined flow angle generally increases onset flow decreases flow approaches receiving basin flow island tends align channel lateral outflow primary channels influences hydraulics flow throughout length transition confined flow coastal river significant impact flow hydraulics resulting transport dynamics solids american society civil engineers
paper embedded control system developed measure yield strength material plate applied load systematic approach proposed handle special requirements embedded control systems different computer based control systems much less hardware resources computational power available efficient control algorithm designed remove cpu burden microcontroller enough power available three step approach proposed address embedded control issue firstly mathematical description whole system studied using theoretical experimental methods mathematical model derived physical models component used experiment retrieved employing method least square estimation identify specific parameters system model secondly feedforward plus feedback controller designed simulated preparation embedded system implementation cerebellar model controller chosen feedforward part controller used feedback part train finally proposed algorithm applied embedded system experiments conducted verify identified model designed controller
magnetic shape memory alloys type smart material exhibit large amount strain subjected applied compressive stress presence magnetic field applied magnetic field presence compressive stress macroscopic strains result orientation variants potential applications include power sensors actuators applications stress assumed applied axial direction magnetic field assumed applied transverse direction realize full potential optimize designs mathematical model predict material response potential loading conditions needed developed phenomenological model characterizes response axial compressive stress applied magnetic field based thermodynamic principles paper similar thermodynamic framework however simpler function proposed based observation orientation phenomenon forward reverse loading magnetic mechanical loading magnetic domains accurately reflect magnetic field measured experiment revised model shown adequately predict magneto mechanical response loading axial compressive stress applied magnetic field
two stage core analysis method widely used core analysis purpose study develop core analysis model coupled analysis within two stage calculation scheme using assembly based thermal hydraulics calculation core analysis model changes lattice physics scheme couples analysis evaluates thermal hydraulics characteristics within coolant flow area divided regions order couple two analyses fuel assembly parameters assumed verified developed model evaluated heterogeneous problem without control rod present model especially effective control rod inserted condition present model incorporate effect current two stage core calculation method elsevier ltd rights reserved
present high voltage cmos neural interface chip prosthesis measures head motion modulates nerve activity restore vision posture stabilizing application specific integrated circuit neural interface asic chip designed work commercially available microcontroller controls asic via fast parallel interface deliver stimulation pulses bit programmable current amplitude via stimulation channels chip fabricated high voltage cmos process accommodate compliance voltages stimulating nerve branches using current pulses durations short phase asic includes dedicated digital analog converter channel enabling perform complex stimulation asic discrete components cover nearly half generation printed circuit board reducing system size power consumption physiological tests asic based system produced eye movement responses prosthetic stimulation similar observed using sinusoidal modulation stimulus pulse rate pulses per second frequencies elicited appropriately directed slow phase eye velocities ranging amplitude degrees eye velocities evoked showed significant difference test suggesting achieves performance least good larger
background common superficial fungal infection tissues like skin hair nail present study aimed determine clinical pattern north common species prevalent area materials methods laboratory clinical data patients cutaneous infection collected subjected standard techniques results total samples taken showed positive culture commonest clinical type predominant species isolated conclusion prevalence varies geographical location age group affected agents also depend upon site infection various factors
adjuvant chemotherapy important component treatment gastric cancer patients however patients respond drugs aimed develop practical profile based serum micrornas mirnas used predict patients likely respond treatment microarrays used screen resistant cells parental cell lines mirnas related chemotherapy sensitivity correlation expression patterns identified serum mirnas overall survival confirmed patients furthermore also validated signature serum mirnas independent cohort patients screening microarrays focused mir mir mir downregulated mirnas cells mir mir mir upregulated mirnas serum mir mir mir mir useful predicting prognosis patients received adjuvant chemotherapy identified signature four serum mirnas mir mir mir mir combined used risk score overall survival patients higher risk score worse prognosis independent cohort patients signature four mirnas predicted prognosis data showed risk score derived four serum mirnas closely associated overall survival patients received adjuvant chemotherapy
global estimates brain connectivity organizing signal generating fiber segments optimal configuration best describes measured diffusion weighted data promising better stability local greedy methods respect imaging noise however global computationally demanding requires computation times often clinical applications present global algorithm fast parallel implementation acceleration using multi core cpus general purpose gpus method motivated key observation fiber segment affected limited spatial neighborhood words fiber segment influenced fiber segments potentially connected two ends also diffusion weighted signal proximity observation makes possible markov chain monte carlo algorithm used global algorithm concurrent updating independent fiber segments carried experiments show proposed algorithm significantly speed global time maintain even improve performance
background several articles basic sciences published past several years little research exists physician investigators social sciences however numbers training fields number programs offering training fields increasing particularly within addition accountability public funding programs requires knowledge growing population career trajectories aim paper describe first cohorts social sciences characterize training career paths better understand experiences training subsequent research practice methods paper utilizes multi recruitment method novel survey instrument examine understudied population social sciences many completed degrees without formal support survey instrument designed collect demographic training career trajectory data experiences perspectives training career describes routes professional development characterizes obstacles predictors success explores career trends results average length time complete degrees years vast majority completed clinical almost engaged research vast majority employed academic institutions several others held leadership positions national international health organizations went private practice survey responses supply recommendations supporting current areas future research conclusions general social sciences careers fit goals agencies providing public funding training physician investigators involved mutually informative medical research clinical practice teaching working improve responses social cultural political determinants health health care findings provide strong evidence continued improved funding support social sciences
paper describes novel identification method mechanical two mass systems influence varying parameters operation conditions performance identification procedure carried control drive system based frequency response measurement mechanical setup extended speed adaptive observer structure serves speed estimate calculation diagram extension observer structure speed estimation mechanical model allows reliable identification various two inertia systems within two identification steps paper gives overview new identification procedure results investigations toward robustness limitations varying speed load conditions different signal processing method underline applicability presented method
paper new framework introduced develop coupled active reactive market distribution networks distributed energy resources synchronous machine based distributed generations wind turbines offer active reactive powers proposed market considered reactive power structures introduced based capability curves also hourly speed variations wind turbines considered proposed model distribution company active reactive powers market via market demand side active responsive loads participate market using demand program objective function proposed market minimize active reactive power costs distribution companies penalty cost emission cost running demand program effectiveness proposed method examined bus radial distribution test system
aim study aim evaluate progression free survival overall survival patients metastatic clear cell renal cell carcinoma treatment patients methods years enrollment years follow consecutively presenting patients men women treated results total patients died patients survived median treated patients months months median months median months patients treated conclusion development induced hypothyroidism hypertension neutropenia edema significant predictive prognostic factor
introduction previous studies demonstrated high prevalence cigarette smoking patients presenting emergency department acute asthma despite clinical public health importance recent multicenter efforts characterize patient population aimed update prevalence cigarette smoking among patients asthma exacerbations methods multicenter chart review study eds across states identified patients aged years asthma exacerbations classified patients three groups based smoking status never former current fit multivariable logistic regression models examine independent predictors current results enrolled patients never smokers accounted former smokers current smokers multivariable model demonstrated several independent predictors current smoking older age age years non hispanic white black public insurance asthma specialist conclusion large multicenter study patients asthma exacerbations demonstrated one three patients current smokers burden current smokers changed multicenter findings late high burden suggests current measures manage tobacco use high risk patients elsevier ltd rights reserved
superior broadband performance frequency planar beam filters relative conventional true time delay recently reported using computational real time antenna test range resulting significant improvements bit error rates presence broadband interference massively parallel systolic circuit architectures also reported int circuit theory appl case direct form signal flow graph sfg architecture operating maximum throughput antenna frames per clock cycle superior broadband performance frequency planar beam filters extended direct form signal flow graph sfg architecture int circuit theory appl novel differential form sfg architecture order reduce overall complexity proposed method employs differential form frequency planar beam sfg corresponding circuit architecture implement required input output space time difference equation resultant digital hardware significant advantage much reduced multiplier complexity relative direct form structure example look ahead employed architectures two three four phases corresponding reductions multiplier complexity respectively proof concept prototype circuit designed implemented fpga device two phase case operating frame rate million linear frames per second uniform linear array corresponding frames per clock cycle circuit clock frequency mhz circuit optimized low critical path delays using look ahead order three ultra wideband radio frequency implementations fields radio radar wireless communications custom versions proposed circuits required
work aimed improve teaching effect practice link water pollution control engineering described reform activated carbon adsorption experiment one hand changed traditional data analysis method cod adsorption experiment according practice experience hand added new comprehensive experiment effects dosage dye kind kind temperature discussed via practice reform proved successful increasing students ability applying theory practice research interest
acquired anemia hematological disease characterized failure bone marrow hematopoiesis resulting immune mediated destruction hematopoietic stem progenitor cells plays central role pathophysiology acquired transforming growth factor beta tgf beta crucial adjusting immune system aim study investigate role tgf beta gene polymorphisms susceptibility acquired via approach genotyped patients acquired controls derived conclusion genotype significantly associated decreased risk acquired adjusted furthermore decreased risk pronounced among male patients adjusted severe severe patients adjusted compared controls subgroup analysis however significant increased risk observed genotype distributions genotype adjusted compared genotype among patients controls severity stratification analysis results indicated tgf beta gene polymorphisms involved acquired chinese population initial analysis provides valuable clues study tgf beta pathway genes acquired
paper presents numerical approximation technique boltzmann equation based moment system approximation velocity dependence discontinuous finite element approximation position dependence closure relation moment systems derives minimization suitable divergence divergence based closure yields hierarchy symmetric hyperbolic moment systems retain fundamental structural properties boltzmann equation approximation position dependence based discontinuous finite element method resulting combined discontinuous moment method corresponds approximation boltzmann equation form new moment closure formulation new numerical flux function based half space approximate distribution establish proposed flux ensures entropy dissipation discontinuous finite element approximation numerical results presented one dimensional test case elsevier ltd rights reserved
paper presents results long term continuous hydrologic simulation analysis watershed scale residential rainwater harvesting rwh program watershed san california usa environmental protection storm water management model simulated rainfall runoff responses variations rwh network including rwh unit storage size number implementing households amount time unit allowed release captured runoff drain delay time takes unit drain coefficient discharge comparison results found reductions increase linearly capacity implementation maximum long term watershed volumetric reductions observed period analysis range rwh storage sizes ratio flow ranging exhibits ability fully capture majority annual long term events sensitivity analysis found regional precipitation characteristics runoff impact long term watershed reduction potential available rwh capacity drain delay control dry duration time increased reduction variability though long term reductions significantly impacted normalization net present value volumetric reductions yielded rwh unit cost per watershed runoff reduced average per year minor variations cost based extent watershed implementation highlights potential institute rwh programs case study location rain provided greatest cost effectiveness reducing average runoff per analysis period elsevier rights reserved
people develop false memories aggressive acts process compare developing false memories current research used simple false feedback procedure implant false memories aggressive acts causing black eye spreading malicious receiving black eye compared false memories subjects true memories equivalent events false aggressive memories easy implant particularly individuals towards aggression implanted false memories indistinguishable true memories events several dimensions including emotional content implications aggression related memory generally false discussed elsevier rights reserved
pulse train repetition ratio pulse range dominant factors achieve high treatment high energy density achieving precise control according purpose treatment diagnosis important method controlling action time changing pulse train repetition range used mainly output pulse transcranial magnetic stimulation achieve safe control circuit operation transcranial magnetic stimulation operated power device control section research carried motion output characteristics transcranial magnetic stimulation according current pulse waveform pulse train stimulation coil result transcranial magnetic stimulation output efficiency reduced transcranial magnetic stimulation output showed regular increase according increase pulse train repetition rate pulse repetition rate increased charged voltage study introduces treatment pulse using transcranial magnetic stimulation changing various bacteria caused rat head one obtain good changing characteristics various bacteria adjusting charging voltage treatment pulse forming magnetic field inducing time
caused bridge failures catastrophic consequences aim study develop verify mathematical model predictions new approach taken combines shallow water equations non pressure corrections non uniform mesh horizontal terrain following layers vertical approach significantly improves computational efficiency conventional computational fluid dynamics approach concluded emerging lateral sides cylinder patterns migrate upstream towards upstream nose upstream side continues grow bed slope reaches angle sediments downstream side grows equilibrium reached hole downstream upstream presence causes strong near upstream nose strong vortex foot upstream side weak vortex downstream side predicted flow velocity depth agree measurements terrain following layer feature particularly useful computations high efficiency makes model practical field scale applications highly relevant improved design foundations control
single report examined risk factors predict future onset type eating disorder core symptom dimensions disorders addressed aims advance knowledge regarding risk factor specificity data prevention trials targeted young women body dissatisfaction age collected annual diagnostic interview data year follow combined identify predictors subthreshold threshold anorexia nervosa bulimia nervosa binge eating disorder bed disorder negative affect functional impairment predicted onset eating disorders thin ideal internalization body dissatisfaction mental health care predicted onset subthreshold threshold bed positive expectations denial cost thin ideal fasting predicted onset disorders similar risk factors predicted core eating disorder symptom onset low bmi specifically predicted onset subthreshold threshold low bmi subset factors showed unique predictive effects multivariate models likely due moderate correlations risk factors results provide support theory pursuit thin ideal resulting body dissatisfaction unhealthy weight control behaviors increase risk binge spectrum eating disorders suggest youth inherently lean rather thin ideal risk impaired interpersonal functioning negative affect risk factors suggesting factors targeted prevention programs general scientific summary findings suggest pursuit thin ideal resulting body dissatisfaction weight control behaviors increase risk developing eating disorders involving binge eating unhealthy weight control behaviors inherently lean young women rather thin ideal risk eating disorders involving low body weight findings also suggest negative affect impaired interpersonal functioning factors increase risk full spectrum eating disorders
conventional normalized adaptive filter using constant step size generally faces inherent trade steady state convergence rate propose herein variable step size algorithm minimizing mean square deviation optimal weight vector weight vector estimate utilization shrinkage technique estimation error involved step size adaptation individually proposed algorithm capable tracking non stationary environments without explicit assumption input signal proposed algorithm exhibits low steady state even input signal colored simulation results validate low good tracking ability proposed algorithm system identification application elsevier rights reserved
paper applied expansion method class integral differential equations viscoelastic fluid solution procedure method help symbolic computation matlab simplicity obtained results show expansion method effective
small molecule inhibitor cyclin dependent kinases vitro activity lymphoid malignancies two concurrent phase trials evaluated relapsed refractory chronic lymphocytic leukemia cell lymphoma using recommended phase dosing twice weekly every weeks primary objective objective response rate nineteen patients four patients achieved stable disease two patients achieved partial response one additional patient subsequently achieved months completion tumor syndrome reported conclusion safely administered patients relapsed refractory patients tumor reductions low activity noted
physics flows consists complex interaction chemical reactions fluid mechanics radiation temperature one important parameters processes laser based imaging techniques frequently used assess temperature information reactive systems without system study verify feasibility temperature measurement tunable absorption spectroscopy technology methane air flat flame selected target test combustion stability kind flame temperature measurement distribution radical flat flame different operating conditions obtained using planar laser induced fluorescence low equivalence ratio radicals distribute uniformly flame adequate oxygen gas condition uniform distribution flame selected tunable absorption spectroscopy measurement selection absorption lines measurement spectrum band simulated considering slope sensitivity snr test transitions suitable temperature measurement flame dye laser frequency doubled laser used generated laser dye laser operated mixed dye high conversion efficiency investigate transitions laser tuned similar similar separately step pulses recorded step laser pulses reflected beam collected detector pulses passed flame collected detector signal two detectors recorded acquired computer automatically line shape transitions obtained fitting experimental data function integral ratio fitting results two lines calculated temperature flame deduced integral ratio temperatures different positions surface varied heights flame center obtained measuring integrated absorption ratio two transitions test results method compared report reference temperature structure measured ways results two tests agree shows method potential calibration two dimension flame two line
kinase kinase members family membrane enzymes small lack relationships family proteins including water soluble kinases exhibit unusual structure active site architecture escherichia coli plays important role recycling produced product biosynthesis molecules located space seems play analogous role gram positive bacteria importance evident essential biofilm formation oral pathogen streptococcus also long served model system studies membrane protein bio catalysis folding stability structure review explores current understanding microbial physiology enzymology structural biology folding family based years studies
rna sequencing use high throughput next generation sequencing technology survey characterize quantify transcriptome genome rna sequencing used analyze pathogenesis several malignancies melanoma lung cancer colorectal cancer rna sequencing identify differential expression genes mutated genes fusion genes gene isoforms disease states rna sequencing used investigation several colorectal diseases colorectal cancer inflammatory bowel disease ulcerative colitis crohns disease irritable bowel syndrome
estrogen receptor progesterone receptor human epidermal growth factor receptor lacking triple negative breast cancers leading cause death successful transport receptor mediated targeting image guided treatment serious challenge cancer therapy work acid encapsulated nanoscale metal organic framework developed surface nanoparticles targeted responsive anticancer drug carrier construct assembled core drug delivery system taken outstanding properties acid encapsulated based metal directly developed labeled towards cells mda normal cell lines anticancer drug doxorubicin encapsulated high drug loading efficiency per shows responsive drug release loaded successfully mda cells receptor mediated exhibits higher cytotoxicity normal cells flow cytometry nuclear apoptosis studies suggest present potential applicable breast cancer therapy reduce side effects elsevier rights reserved
facial hair strongly influences peoples judgments mens sexual attributes however nature judgments often contradictory levels intermediate facial hair growth presented raters stage female raters menstrual cycles influenced past findings quantified mens womens judgments attractiveness health masculinity parenting abilities photographs men clean heavily fully also tested effect menstrual cycle hormonal contraceptive use womens ratings women judged faces heavy attractive heavy light clean faces similarly less attractive contrast men rated full heavy attractive followed closely clean light least attractive men women rated full highest parenting ability masculinity ratings increased linearly facial hair increased effect pronounced women fertile phase menstrual cycle although attractiveness ratings differ according fertility findings confirm affects judgments male socio sexual attributes suggest intermediate level attractive full men perceived better fathers protect offspring elsevier inc rights reserved
brain derived neurotrophic factor bdnf plays important role activity dependent synaptic plasticity altered blood bdnf levels frequently identified people autism spectrum disorders asd however wide discrepancies evidence therefore performed present systematic review meta analysis aimed qualitative quantitative synthesis studies measured blood bdnf levels asd control subjects observational studies identified electronic database searching also hand searching reference lists relevant articles total papers initially identified review eventually twenty studies included meta analysis meta analysis blood bdnf patients asd control subjects demonstrated significantly higher bdnf levels asd compared controls addition subgroup meta analyses performed based bdnf specimen present meta analysis study led conclusion bdnf play role autism initiation propagation therefore considered possible biomarker asd
effective separation electron hole pairs plays key role enhancing photo catalytic performance density electrons participating reduction reaction also determines photocatalytic performance report rational design photocatalyst assembly composed type two dimensional carbon nanotubes exhibits enhanced density electrons controlled unidirectional change flow promote photocatalytic hydrogen evolution reaction hot electrons conduction band increase density electrons act power pump electrons electron flow conduction band photocatalytic performance assembly dramatically enhanced evolution water enhanced photocatalytic activity due efficient unidirectional transfer electrons high density efficient separation pairs elsevier rights reserved
paper deals use robotic operating system ros educational tool control engineering students software suite fact simplifies required effort distributed systems networks helping development learning tools robotic control fields particular present tool allows user understand tuning behaviour proportional integral derivative pid controllers used control first order plus dead systems distributed networks ifac international federation automatic control hosting elsevier ltd rights reserved
monitoring human hydration level key factor preventing urinary system disorders paper proposes smart holistic system comprises two components urine colour measurement system installed mobile app used interact measurement unit track users view statistical data advice main prototype built based low cost embedded internet devices coupled rgb sensors light sources based rgb theory system tested laboratory using liquid mixed food colour different results presented mobile app system successfully implemented ubiquitous self test solution raising awareness user friendly way
objective hypertension obesity low fitness associated increased risk cardiovascular event overweight obese individuals current study aimed estimate cardiovascular risk vascular age profiles analyzing potential sex differences determine whether higher age whether associated low level methods overweight obese non hispanic white participants men women primary determined using new pooled cohort risk equations method respectively considering values peak oxygen uptake participants divided sex results higher men compared women irrespective age irrespective sex higher age age bmi higher low group compared groups differences values separated groups conclusion pooled cohort equations underestimate risk suffering cardiovascular event following years overweight obese non hispanic white women compared men appears useful tool communicating population irrespective sex alone enough moderate copyright wolters kluwer health inc rights reserved
bases family variable known show enhanced growth inhibitory properties view facts part continuous interest cationic bases developed several base ligands present study compounds characterized various spectroscopic methods infrared spectra nmr nmr ray three namely exerted strong growth inhibitory properties inhibiting highly metastasis prostate cancer growth ethyl phenyl moiety displayed potent activity cell lines tested data obtained analysis establishes phenyl enhances growth inhibitory properties compound result serve lead scaffold rational anticancer agent development elsevier rights reserved
energy conservation emission reduction issues construction phase buildings increasingly important meet challenges sustainable building technological advancement considered one essential driving forces green sustainable construction effective expected anticipated energy conservation efficiency improvement partially even totally offset energy effect exists paper research gap quantitatively investigating impacts technological advancement energy consumption chinas building construction industry incorporating direct effect first technological advancement rate terms energy efficiency measured constructing energy environmental non radial directional distance function provides strong support hypothesis second incorporating asymmetric energy price decomposition framework cost function estimated energy savings energy efficiency improvement chinas construction industry offset due effect based measured results technological advancement rate effect analyses find technological advancement contributes million standard coal equivalent energy conservation construction industry period energy saved sector effect empirical findings paper reveal technological innovation energy pricing reforms policies environmental regulations implemented achieve effective energy conservation green building construction elsevier rights reserved
means formation enthalpy model model excess free energy formation excess activity values components ternary alloy calculated computer programming experimental results show formation excess free energy excess ternary alloy negative whole content range minimum values obtained mol mol center dot respectively activity curves show activity values ternary alloy rapidly decrease decrease molar fraction values small molar fraction decreases means strong interaction stable compounds form ternary alloy system
background prior studies suggested inhibited temperament associated increased risk developing anxiety mood disorder including bipolar disorder however neurobiological basis increased risk unknown aim study examine temperament symptomatic asymptomatic child offspring parents bipolar disorder investigate whether inhibited temperament associated aberrant hippocampal volumes compared healthy control youth methods group consisted youth current psychiatric symptoms without psychiatric symptoms compared youth temperament characteristics measured using revised dimensions temperament survey magnetic resonance imaging used measure hippocampal volumes association temperament hippocampal volumes tested using multiple regression analysis results compared group group significantly inhibited temperament traits less flexibility negative mood less regular rhythm daily routines contrast group likely approach novel situations compared groups within group inhibited temperament associated smaller right hippocampal volumes conclusions study symptomatic characterized inhibited temperament inversely correlated hippocampal volume additional longitudinal studies needed determine whether inverse correlations hippocampal volume inhibited temperament represent early markers risk later developing bipolar disorder
low carbohydrate intake regulated controlled production bodies causes physiological state known dietary bodies flow liver extra hepatic tissues brain use fuel glucose metabolism via mechanism similar glucose oxidation fatty acids alternative fuel comparison glucose bodies actually good respiratory fuel indeed clear requirement dietary carbohydrates human adults interestingly effects body metabolism suggest mild offer therapeutic potential variety different common rare disease states also recent study showed low carbohydrate diet resulted significant reduction fat mass concomitant increase lean body mass normal weight men contrary popular belief insulin needed glucose uptake utilization man finally muscle fat carbohydrate burn amino acid flame journal international society sports nutrition
background infectious disease host immune inflammatory responses play essential roles resistance bacterial infection induction tissue destruction immune response dysregulated triggering receptor expressed myeloid cells modulates inflammatory innate immune signaling considered amplifier immune response negative regulator yet explored periodontal disease hypothesized participated innate immune responses pathogenesis periodontitis therefore aim study evaluate expression tissues patients chronic periodontitis healthy subjects correlation clinical periodontal parameters study first identify periodontal tissue protein expression changes periodontal tissues material tissue sections collected healthy subjects patients chronic periodontitis immunohistochemistry quantitative real time polymerase chain reaction employed evaluate protein mrna expression receptors tissues recorded clinical parameters probing depth clinical attachment loss plaque index bleeding probing addition myeloid cells connective tissues also found expressed epithelial cells particular detected almost epithelium healthy inflamed biopsies expression levels significantly increased periodontitis group compared healthy group increased levels receptors positively correlated site specific periodontal parameters conclusionthe increased expression levels periodontitis confer diagnostic potential therapeutic targets indicating association clinical severity disease
pacific island country high solar electricity national grid order reduce dependence imported fossil fuel however pose technical challenges reliable operation small isolated system work technical analysis carried investigate implications planned pipeline grid connected systems power system variations output corresponding reserve requirements balance short fall power output analysed utility network modelled using software steady state dynamic analyses carried simulated scenarios major concerns identified times high load high output low system demand high output dispatch constraints identified current grid system sustain maximum capacity load require load dynamic simulations showed fast negative output lead frequency instability time low demand maximum output system stable low loads maximum output conditions exist elsevier ltd rights reserved
background use cannabis illegal drugs particularly prevalent male young adults associated severe health problems longitudinal study explored variables associated onset cannabis use onset illegal drug use cannabis separately male young adults including demographics religion health social context substance use personality furthermore explored far gateway hypothesis common addiction model line resulting prediction models methods data gathered within cohort study substance use risk factors young men aged around years provided demographic social health substance use personality related data baseline onset cannabis drug use assessed months follow samples individuals indicated baseline used cannabis drugs respectively life provided follow data used prediction models hierarchical logistic stepwise regressions conducted order identify predictors late onset cannabis drug use separately results providing siblings parental lower parental knowledge peers peer pressure low nicotine dependence sensation seeking positively associated onset cannabis use religion negatively associated onset cannabis use onset drug use cannabis showed positive association antisocial personality disorder lower parental knowledge peers psychiatric problems peers problematic cannabis use sensation seeking conclusions consideration predictor variables identified within study help identify young male adults preventive measures cannabis drug use appropriate results provide evidence gateway hypothesis common addiction model point variables like religion influence onset drug use
issue addressed important strategy increasing childrens physical activity enhance childrens opportunities school physical activities yet little influence school physical childrens health related quality life hrqol purpose present study explore relationship australian primary school childrens enjoyment physical activities hrqol methods study consisted children two australian primary schools aged years enjoyment activity play questionnaire used measure school childrens enjoyment school physical activities pediatric quality life inventory used measure childrens hrqol researchers applied linear regression modelling investigate relationship childrens enjoyment school physical activities hrqol results discovered primary school childrens enjoyment vigorous type school physical activities playing range weather conditions associated childrens improved hrqol conclusion findings study suggest health providers researchers consider providing primary school children opportunities facilities vigorous intensity school physical activities key strategy enhance childrens hrqol considering social ecological model framework key predictors childrens enjoyment school physical activities provide valuable insight school health providers multiple levels influence childrens hrqol developing school settings activities school
paper proposes fractional order pid controller improve positioning ability conducting polymer actuators novel class smart material based actuators controller design process performance requirements constraints crucial precise positioning fast settling time low steady state error overshoot control voltage considered order obtain optimal controller parameters search particle swarm optimization pso meta heuristic search methods utilize fractional order model specifically defined fitness function used algorithms compared terms convergence rate success converging optimal solution order test performance controller pid controller also tuned algorithms controllers implemented experimentally results show controller tuned csa provided less overshoot settling rise time tuned pso performance pid control slightly worse controllers terms transient steady state response although search algorithms satisfied control input constraint pid controllers csa tuned pid controller required smallest control signal elsevier ltd rights reserved
present work use sequence two solar photocatalytic processes investigated removal copper iron zinc acid used agent real soil washing effluents removal efficiencies copper iron zinc achieved outdoor solar photocatalytic treatments using parabolic trough collectors carried italy degrees degrees period june july removal efficiencies achieved incident solar energy per unit volume calculated taking account irradiated surface area estimated present work solar irradiance measurements collected experiments results suggest two step solar process adopted proposed useful solution problem heavy metals organic agents soil washing assessment using different living organisms showed noticeable decrease soil washing effluents two step photocatalytic process elsevier rights reserved
purpose review purpose present review provide update current development field broadly neutralizing antibodies potential use prevention therapeutic settings evaluation cell abnormalities impair antibody responses hiv infection recent findings major advances achieved characterization directed different vulnerable regions hiv envelope recent observations clearly demonstrated ability prevent hiv infection model hiv infection suppress individuals chronic hiv infection absence antiretroviral therapy furthermore substantial advances also obtained development hiv proteins immunization strategies inducing small animal models several studies also light cell abnormalities associated phase hiv infection cause impaired cell maturation antibody responses note preliminary observations provided evidence correlation expansion specific population cells example center cells expansion follicular helper cells generation neutralizing antibodies summary recent observations antiviral effects vivo indicate play central role prevention therapeutic settings identification role center cells cells critical components immune response leading generation neutralizing antibodies allow development specific immunization strategies stimulation center cells cells lot work still remains done cell cell biology human lymphoid tissues development hiv proteins immunization strategies leading generation
technology virtual reality result progress science technology since century embodied computer technology computer graphics multimedia technology sensor technology display technology human body engineering human computer interaction theory latest achievements artificial intelligence fields become latest achievements relay information field multimedia technology network technology widely attention research development application hot spots currently fastest growing multi disciplinary comprehensive technology rapid generating equipment interaction changed past people computer passive way communication make man machine interaction become humanized new research field human computer interaction interface provides new interface application intelligent engineering tools kinds engineering provides new description method large scale data visualization also changed way people work lifestyle ideology
background american indian experience historical trauma thought source inter trauma responses potential causative factor long term distress substance abuse among communities aims present study evaluate extent frequency thoughts historical loss associated symptoms influenced current traumatic events post traumatic stress disorder ptsd cultural identification percent native american heritage substance dependence affective anxiety disorders conduct disorder antisocial personality disorder aspd methods participants american recruited assessed semi structured assessment genetics historical loss scale historical loss associated symptoms scale quantify frequency thoughts symptoms historical loss stressful life events scale assess experiences trauma orthogonal cultural identification scale results three hundred six american indian adults participated study half indicated thought historical losses least occasionally caused distress logistic regression revealed significant increases often person thought historical losses associated married high degrees native heritage high cultural identification additionally anxiety affective disorders substance dependence correlated historical loss associated symptoms conclusions american indian community thoughts historical losses associated symptomatology common presence thoughts associated native american heritage cultural identification substance dependence elsevier ireland ltd rights reserved
red eye used general term describe eyes sign acute chronic localized systemic underlying inflammatory condition injection commonly caused allergy visual fatigue contact lens local infections instances red eye represent true ocular emergency treated comprehensive assessment red eye conditions required preserve patients visual function severe ocular pain significant decreased vision history ocular trauma warning signs demanding immediate consultation
extensive evidence perceived internally planned actions common basis action observation induce automatic tendency others perceived executed action however based shared representations question arises distinguish self related related representations suggested control shared representations involves neural network centered parietal junction however specific role controlling shared representations still clear conflict situation participants execute action observing action either facilitate relevant action inhibit irrelevant action mirror response present study used transcranial direct current stimulation condition neural activity right parietal junction analyzed output indexed motor evoked potentials induced single pulse left primary motor cortex action observation context conflict task results showed mediated increased control attenuation task irrelevant response activation effect motor suppressed reduced rather facilitating activity via selectively enhanced instructed motor plan self related representation outcome supports idea plays critical role detecting mismatch self related related representations work enhance task relevant representations
included herbal foods supplements natural enhance weight loss considering public health legal regulations urgent need effective rapid reliable techniques detect herbal foods dietary supplements research comprehensively explored first time detection green tea green coffee mixed herbal tea using ftir spectroscopic technique combined hierarchical cluster analysis pca principle component analysis techniques employed spectral range classification discrimination distance algorithm samples classified discriminated respect contents perfect accuracy without false prediction results suggest existence active substance successfully determined levels range totally green tea green coffee mixed herbal tea using ftir technique combined elsevier ltd rights reserved
application nanocomposite point improve crude oil novel efficient technique receives much attention however effects nano alone crude oil unclear now paper different sizes successfully synthesized two step route effect flow behavior two typical crude oils studied results showed oil phase single spheres small dosage significantly decreases point elastic modulus viscous modulus apparent viscosity yield stress two oil samples indicating improve flow behavior crude oil temperatures appearance temperature flow improving efficiency greatly influenced size dosage moreover adding oil samples also inhibits precipitation capable part however little influence character microstructure two oil samples similar tests model oil confirmed participate precipitation process change morphology crystals impede interactions crystals effect inhibits development crystal network structure thus improves flow behavior oil mechanism brings new way improve flow behavior crude oil development new generation flow based nano elsevier ltd rights reserved
current rural medical information construction still large amount medical data related common rural disease used low utilization rate order improve utilization data provide help rural doctors rural residents developed distributed implied semantic text retrieval model improved weight calculation formula implied semantic text retrieval based implied semantic text retrieval distributed computing technology experiment results indicate retrieval framework shorten time text retrieval improve accuracy text retrieval
dramatic technology progress data manipulation induced several attempts illegal processing regard several protection techniques including cryptography used avoid illegal production distribution data online side attacks still major problem limits effectiveness techniques geometric attacks involve displacement pixels therefore induce synchronization errors original image recovery process order solve synchronization problem propose use robust technique different geometrical data image correct geometric distortion work propose novel invariant digital image approach based geometrical feature cover image three constraints approaches embedded embedding capacity robustness aim idea work propose blind robust digital image scheme based law provides best synchronization embedded data attacks application law used propose auto algorithm compute optimal embedding gain factor bit order ensure hidden data firstly invariant features host gray scale image extracted using edge detector saved keys points set generated select optimal robust embedding simulation results illustrate embedded data robustness proposed approach intentional geometrical attacks presented finally section copyright john wiley sons ltd
background myocardial microvascular loss myocardial infarction remains therapeutic challenge autologous stem cell therapy considered alternative however shown modest benefits due effects cardiovascular risk factors stem cells adipose derived stem cells overcome limitations low immunogenicity potential good candidates cell therapy present study investigated effects released products cardiac post methods pig subcutaneous adipose tissue isolated expanded gfp labeled angiogenic function assessed vivo membrane cam model pigs underwent induction days randomized receive infusion conditioned media intravenous infusion placebo control cardiac damage function monitored cardiac magnetic resonance imaging upon infusion baseline weeks thereafter assessed density angiogenic markers collagen deposition fibrosis collagen differential proteomics performed characterize protein signature results cam indicated significant capacity pigs placebo animals displayed impaired cardiac function weeks infusion baseline administration significantly enhanced formation favored cardiac repair post groups molecular markers angiogenesis significantly upregulated transcriptional protein levels silico bioinformatics analysis proteome indicated activation coordinated protein network involved formation resolution conclusion synergistically contribute coordinated upregulation protein
evolution long water waves small amplitude surface waves weak nonlinearity weak dispersion weak perturbation fluid mechanics three spatial dimensions described generalized dimensional variable coefficient equation studied paper symbolic computation via truncated expansion auto backlund transformation derived based certain variable coefficient constraints one soliton two soliton wave wave solutions respectively obtained via method graphic analysis shows soliton varying soliton direction change value one equation cause change soliton shape soliton amplitude affected change represents dispersion respectively stand disturbed wave velocities along directions perturbed effects scaled spatial coordinates temporal coordinate soliton direction type interaction two solitons vary change value affected wave wave respectively displayed wave comes extreme behaviour wave elsevier ltd rights reserved
proteins emerged important regulators disease developmental processes gain insight mechanistic actions family performed comprehensive characterization prototype member protein histone methyltransferase using biochemical biophysical chemical biology techniques present paper report first known molecular characterization methylated recombinant histone identification new histone substrates enzyme single mutant set domain demonstrated significantly activity additionally optimized robust biochemical assay amenable high throughput screening facilitate generation small molecule chemical probes protein family present study provided valuable insight enzymology intrinsically active protein
parkinsons disease neurodegenerative disease characterized selective degeneration dopaminergic neurons substantia nigra encoded ubiquitin frequently mutated gene linked autosomal recessive early onset familial tested effect ethanol induced dopaminergic neurodegeneration knockout transgenic mice chronic ethanol feeding male wild type mice weeks old fed diet containing ethanol weeks compared responses found knockout ethanol induced behavioral impairment dopamine depletion mechanism study found knockout increased reactive oxygen species ros production formation mitochondrial dysfunction expression pro apoptotic proteins decreased expression pro proteins knockout also increased ethanol induced activation mitogen activated protein kinase addition ros production formation mitochondrial dysfunction expression pro apoptotic proteins increased expression pro proteins decreased treatment ethanol sirna cells moreover effects deletion ethanol induced ros generation mitochondrial dysfunction cell death reduced specific inhibitor vitro vivo deficiency ethanol induced dopaminergic neuron damage kinase dependent inhibition autophagy mitochondrial function
ankylosing spondylitis prototype rheumatoid factor negative causes making spine less flexible resulting forward posture year old male known case ankylosing spondylitis presented left rupture raising right foot hit football fitted knee emergency measure extent rupture yet established patient requested leave home right took report herein extremely rare case ankylosing spondylitis atrophy extent causing pathological muscle rupture prolonged period immobilization results muscle leads knee joint instability muscle soon possible
examined mechanisms involved development easily learned easily remembered heuristic three groups young children years years years trial acquisition procedure used evaluate much childrens judgment learning depended heuristic moreover new experimental paradigm composed six phases pretest four training phases posttest employed implicitly influence validity association underlies metacognitive rule results revealed heuristic develops early years use reduced implicit training furthermore executive monitoring found account smaller changes observed older children years training developmental perspective findings present coherent picture childrens learning metacognitive heuristics wherein early automatic implicit learning later followed control elsevier inc rights reserved
background dementia cognitive impairment common older hospital patients associated serious adverse outcomes despite often preventable frequently recognized hospital settings hospital nurses received adequate education training recognizing caring however effective way increasing nurses awareness dementia initiating regular patient screening monitoring guide best practices patients hospital settings known hence current project conducted aims situation implementing multi component non pharmacological evidence based intervention patients educating hospital nurses change practice methods development practice change component informed recent findings implementation science focuses facilitation active ingredient knowledge uptake utilization component focuses educating empowering experienced nurses become cognition across six large australian tertiary referral hospital turn educate nursing team members effectively care patients hospital leadership team supportive project directly involved selecting provided comprehensive education evidence based assessment prevention management practice change management skills receive continuing support research education staff raising awareness staff assessment adoption best practices preventing managing qualitative quantitative data collected multiple time points evaluate process impact outcome provide clarity regarding effective aspects intervention discussion paper describes study protocol implementation multi component evidence based non pharmacological practices designed improve care older hospital patients findings inform subsequent initiatives directed towards enhancing capacity nursing workforce implement best practices providing high quality care growing patient population throughout acute care hospital stay
background visceral hiv aids emerged series disease pattern often results unfavorable responses treatment frequent relapses deaths scarce data available regarding prevalence hiv associated factors among visceral patients study sought determine prevalence hiv associated factors among visceral infected patients methods facility based cross sectional study conducted october august northwest ethiopia cluster sampling technique used select visceral infected patients test results used diagnose visceral hiv diagnosis based national algorithm two serial positive rapid test results case discrepancy two tests gold used tie structured questionnaire used collect independent variables data entered using analyzed using spss version descriptive statistics logistic regression model used analyze data results total study participants included study response rate hiv visceral found age years aor urban residents aor daily workers aor significantly associated hiv visceral conclusion hiv visceral northwest ethiopia found low age residence employment independently associated hiv northwest ethiopia better design interventions prevent control hiv productive age groups age daily
hepatitis virus pathogen associated water pollution contaminated drinking water cause hepatitis outbreaks lead economic losses even threaten human lives difficult detect low levels hepatitis virus water virus concentrated order quantify accurately present simple rapid efficient technique concentration detection hepatitis virus water data showed adding phosphate buffered saline water pre filtering water adding reagent directly filtration membrane significantly improve concentration efficiency three types filtration membranes studied mixed cellulose ester membrane membrane membrane concentration efficiency using mixed cellulose ester membrane pore size highest reaching method used concentrate hepatitis virus water samples lake using green real time reverse transcription polymerase chain reaction analysis detection sensitivity method reached copies concentration efficiency reached
accepted principal nutrient affecting blood glucose diabetes however current guidelines unable specify optimal quantity carbohydrate control studies exist describe current practice amongst healthcare professionals giving carbohydrate advice type diabetes present study aims improve understanding degree variation current practice registered describing patients contacted national networks asked complete online survey analysed using version college station usa three consultations patients type diabetes observed followed semi structured interviews total complete survey responses received advice varied according expertise training confidence complexity patients blood glucose treatment respondents advised patients restrict carbohydrate intake either occasionally frequently considering total energy carbohydrate realistic expectation overall theme interviews conflicting priorities three sub themes treatment decisions made difference empowerment advice iii contradictory advice disparity existed observed interview data type carbohydrate advice provided advice varies number reasons consensus exists areas carbohydrate awareness advice however clear definitions terms lacking clarification interventions improve consistency approach improve patient outcomes
background psoriasis chronic condition negative impact patients quality life often requires lifelong effective safe treatment objective analysis focused effect treatment patient reported health related quality life assessed dermatology life quality index patients moderate severe psoriasis methods proportion subjects achieving score response week time score response sustained score response week compared etanercept results subjects received received etanercept score response rates significantly higher etanercept week median time score response significantly shorter versus etanercept weeks majority treated subjects achieved score response week sustained week along reduction psoriasis area severity index total score response limitations placebo comparisons limited maintenance period week conclusion treatment provided faster greater sustained improvements quality life etanercept weeks consistent greater clinical response
progress biomechanical modelling human soft tissue basis development new clinical applications capable improving diagnosis treatment diseases cancer surgical planning guidance interventions finite element method fem one popular techniques used predict deformation human soft tissue due high accuracy however fem associated high computational cost makes difficult integration real time computer aided surgery systems alternative simulating mechanical behaviour human organs real time comes use machine learning techniques much faster fem paper assesses feasibility methods modelling biomechanical behaviour human liver breathing process crucial guiding surgeons interventions critical track deformation specific kind biopsies accurate application radiotherapy dose liver tumours purpose different regression models investigated including three tree based methods decision trees random forests extremely randomised trees two simpler regression techniques model linear regression order build validate models labelled data set constructed modelling deformation eight vivo human livers using fem best prediction performance obtained using extremely randomised trees mean error samples error achieved results lay foundation future development real time software capable simulating human liver deformation breathing process clinical interventions elsevier ltd rights reserved
mining approach mining low large scale product databases order solve financial plants manufacturing industries previous mining methods deal static product databases ignore characteristics items values extract therefore approaches fail solve financial plants significant number mining processes order deal real time product data accumulated plants real world paper propose new tree based mining algorithm dynamic databases finds considering weight conditions incremental databases proposed algorithm uses new tree list data structures performing mining operations efficiently furthermore proposed algorithm capable reducing number considering different weight information items within product databases also compare proposed approach tree based state art methods performing runtime memory pattern quality scalability comparisons respect various real synthetic incremental datasets show proposed algorithm outstanding comparison previous methods elsevier ltd rights reserved
purpose investigate factors lead willingness try electronic cigarettes among adolescents methods sample year old pupils completed questionnaire results smoking status significantly predicted one third variance willingness try electronic cigarette significantly predicted positive prototype negative prototype electronic cigarette user moreover tobacco electronic cigarettes less favorable alternative fruit conclusions findings provide evidence electronic cigarettes appealing adolescents smokers non smokers current past electronic cigarette users never users
research shown emotional events remembered better neutral events also elicit increase false memories present study designed influences valence arousal event memory misinformation paradigm participants shown six types photographs positive high low arousal negative high low arousal ambiguous neutral half exposed misleading information recognition test assessed memory correct false central peripheral details negative ambiguous events elicited fewer correct false memories peripheral details positive neutral events regardless previous exposure misinformation arousal improved memory correct central details negative valence arousal inhibited control participants tendency endorse false central details power emotion power suggestion however latter effect disappeared previous exposure misinformation results discussed light earlier research emotion cognition recent motivational theories implications forensic practice
historical analysis reproductive politics canadian north necessitates careful reading local circumstances regarding language access health services differed culturally features conditioned however international discussions family planning concepts population growth poverty language debates discussions reproduction birth control northern canada producing states logic despite low population density endemic poverty north aggressive family planning measures
article sand sample study inner area determine sand maximum dry density optimum moisture content basis sand cohesion internal friction angle measured quick direct shear test sand optimum moisture content near largest bearing capacity retaining wall model regarded sand determined bearing capacity change sand compared experimental results showed sand wet state cohesion kpa internal friction angle degrees sand bearing capacity plate loading test sand geotextile bearing capacity sand research area provides useful reference construction highway railway application reinforced retaining wall new retaining structure region sand treated special filling material structures
isolation rna tree tissues problematic due large amounts secondary metabolites interfering compounds cells developed efficient rna extraction method yielded high quality rna preparations tissues tree method reported utilized successfully inhibit activities found high ionic strength brought nacl necessary addition secondary metabolites interfering compounds effectively removed using sodium condition quality purified rna tested race northern blotting analysis ensuring rna used subsequent gene expression analysis method successfully applied rna plant species conclusion protocol reported expected excellent applications rna isolation plant tissues
racial inequalities criminal justice pressing problems policymakers prior literature suggests officials disparate criminal justice policies due racial scholarship yet explain officials address racial problems criminal processing article introduces framework racial disparity reform racial disparity reform policy seeks reduce criminal justice institutions treatment racial groups officials pursue policies due ideological beliefs civil rights political interests appearing solve social problems using original database policy article first presents distribution types reform measures adopted officials states examines social political explanations state adopt racial disparity reforms policy predicted worsening problems racial criminal processing control branches absence efforts improve racial fairness within states criminal justice system similar dynamics encourage development different measures types within policies ideological problem solving explanations racial disparity reform show potential officials just criminal justice practices
epilepsy reported occur individuals autism spectrum disorder asd previous studies across world found prevalence estimates ranging examined parent reported prevalence occurring epilepsy asd recent national survey childrens health analyses accounted survey weights account complex sampling design overall analytic sample children ages children asd prevalence children epilepsy prevalence epilepsy reported occur asd cases children asd occurrence epilepsy associated increasing child age female gender intellectual disability speech problems lower socioeconomic status
individuals problem solving deficits higher levels neuroticism increased risk suicide yet little known vulnerability characteristics sample low income primary care patients examined potential mediating role relation neuroticism suicidal behavior potential moderating role social problem solving ability participants completed self report questionnaires suicidal behaviors questionnaire revised social problem solving inventory revised beck scale neo five factor inventory models tested using moderated mediation techniques significant indirect effect neuroticism suicidal behavior indirect effect moderated social problem solving ability patients greater neuroticism also manifest greater levels turn suicidal behavior relations strengthened lower levels social problem solving interventions increase social problem solving ability reduce reduce suicide risk
primary headache disorders including migraine common neurological disorders presenting hospital episodic syndromes associated migraine including recurrent gastrointestinal disturbances abdominal migraine cyclic vomiting often pre date occur onset migraine child risk developing headache condition purpose review evaluate two common episodic syndromes abdominal migraine cyclic vomiting syndrome including pathophysiology common presentations diagnostic criteria differential diagnosis red features outlined approach diagnostic work offered finally provide evidence based review management options long term prognosis future research include randomized trials acute preventive treatment disorders research whether early intervention prevent progression migraine mitigate migraine severity
objective purpose current study identify association polymorphisms insulin like growth factor receptor igf gene insulin like growth factor receptor igf gene osteoporosis postmenopausal women han chinese materials methods case control study involved patients postmenopausal osteoporosis age matched controls genotype polymorphisms igf igf using restriction fragment length polymorphisms rflp polymerase chain reaction pcr assay bmd values lumbar spine femoral neck measured using dual energy ray absorptiometry serum igf investigated enzyme linked immunosorbent assay results data showed distributions genotype allele igf gene polymorphism significantly frequent osteoporotic women controls conditional logistic regression revealed genotype igf statistically associated osteoporosis adjustment age menopause duration bmi genotype still significantly associated increased risk osteoporosis osteoporotic women genotype igf found lower values serum igf bmd femoral neck compared genotype conclusions results suggested igf gene polymorphism affect susceptibility osteoporosis postmenopausal women han chinese change serum igf level
present system called makes easy use implement media rich interactive cloud services usage simplicity achieved providing simple powerful mechanism makes device first class network accessible resource user dynamically bind service time implementation simplicity achieved providing development runtime environment identical typical linux distribution running local machine cloud thus transparent developers users latter concern simply choosing devices via wish interact services system supports classes services optimized difficult class requires gpu render content real time designing implementing cloud transparent system class presents number significant technical challenges describe challenges evaluate performance systems cloud based gpu rendering
paper presents technique recognize power quality disturbances associated solar energy penetration distribution network voltage signal analysed help transform transform features utilized recognize power quality events help fuzzy means clustering operations considered assessment include grid synchronization solar photovoltaic system events associated sudden change solar also investigated proposed study carried using standard ieee bus test system modified incorporating solar system effect increase solar energy penetration terms power quality assessment also investigated solar systems capacities using proposed power quality index maximum deviations frequency total harmonics distortions voltage current study carried using matlab simulink simulation results compared real time results obtained using real time digital simulator validating effectiveness proposed study elsevier ltd rights reserved
introduction young people eating disorders risk harm social emotional physical development life chances although seek help access social media information advice support relationship social media youth subject clearly understood qualitative study aimed explore young people used youth moderated online eating disorders discussion run eating disorders methods applied approach involving thematically analysing messages results data analysis generated five themes taking role online discussion safe space friendship within online flexible help peer support recovery relapse prevention moderation influenced culture discussion findings consistent literature youth preferences mental health self care support young persons decision use discussion pro active self care moderated online discussion make positive contribution support youth eating disorders negative media perceptions online groups conclusion study adds knowledge young people access support via social media online discussion safe acceptable spaces youth access help research provide insights impact moderation
aim replicate genome wide associations effects using finnish patients life study patients methods analyzed association four snps three snps response finnish life patients results variation transcription start site associated blood pressure response men life response correlated baseline plasma levels substrate end product respectively study variation associated effect life conclusion provide support two markers beta blockers angiotensin receptor antagonists
condition great interest researchers clinicians dental medical areas two circadian manifestations occur sleep sleep however suffered together recent investigations suggest central nervous system neurotransmitters genes involved genesis serotonin responsible circadian rhythm maintaining arousal regulating stress response muscle tone breathing thus serotonin associated pathogenesis aim work evaluate frequency genetic polymorphisms genes subjects undergoing treatment patients included classified according diagnosis patients sleep patients patients control group included healthy patients signs data showed significant differences allelic frequencies polymorphism allele associated increased risk odds ratio confidence interval results suggest polymorphisms serotonergic pathways involved sleep research needed clarify increase current understanding
building design construction require collective effort diverse project participants coordination performance project participants important effective management needs assessed periodically however quantitative way measure coordination measuring coordination time consuming particularly project execution phase study proposes easy procedure monitoring performance project participants degree centrality measures project participants project major construction project calculated using social network analysis communication network participants centrality index defined firm based average three centrality measures firms coordination score also calculated based content analysis sent received participants coordination scores found highly correlated centrality indices define role firm centrality index therefore measured easily using simple software number direction participants rather performing time consuming content analysis exchanges calculate coordination scores
despite improved understanding disease biology use multi agent chemotherapy long term survival adults cell acute lymphoblastic leukemia ranges management patients relapsed group characterized outcomes poses clinical challenge address unmet need novel therapeutics investigated setting relapsed encouraging results important cell antigen expressed cases undergoes constitutive antibody ligation making attractive biologic target targeted antibody drug conjugate demonstrated impressive single agent activity even among heavily pretreated relapsed patients recent randomized phase iii clinical trial demonstrates superiority standard care chemotherapy first second line therapy relapsed review summarize preclinical clinical data available date using relapsed
political debate adolescents access emergency contraception available counter going years since levonorgestrel plan one step used united states emergency contraception prescription time fda done years research testing barr laboratories manufacture plan one step make safe females ages fda recommended counter use plan one step ages yet occur across nation young women find impossible purchase product whether age politics making choices young females medical evidence long going let continue
comparative enzymology explores molecular mechanisms alter properties enzymes best fit adapt biotic demands abiotic stresses affect cellular environment protein catalysts function many years comparative enzymology primarily concerned analyzing enzyme functional properties substrate affinities effectors responses temperature etc order determine enzyme properties optimized function changing conditions recently became apparent modifications enzymes play huge role metabolic regulation first modifications appeared target just crucial regulatory enzymes recent work showing many also targets modification leading substantial changes enzyme properties present article focuses particular lactate dehydrogenase ldh showing stress induced changes enzyme properties linked reversible modifications changes phosphorylation state ldh occur response dehydration stress exposure furthermore studies show ldh also target modifications including acetylation methylation change response dehydration stress selected new methods exploring modifications discussed new challenges future comparative enzymology presented help achieve deeper understanding biochemical adaptation enzyme regulation elsevier inc rights reserved
humans two splice variants glucocorticoid receptor exist canonical isoform beta isoform shown dominant negative effect alpha previously established occurrence beta isoform zebrafish present study investigated functional role zebrafish beta beta reporter assays cells demonstrated dominant negative effect beta effect observed zebrafish cells using induction binding protein gene readout subsequently generated transgenic fish line inducible expression beta transcriptome analysis suggested transcriptional regulation genes beta line validation failed confirm role based results low expression level poor evolutionary conservation suggest zebrafish beta isoform functional role transcriptional regulation elsevier rights reserved
todays high technological world scientific discoveries contribute remarkable development human life also adverse impact among advancements media one aims capturing group viewers transmit information via various media violence considered one determinants individual primary goal health professional work maintenance mental health therefore imperative create understanding impact media violence mental health particularly context violence become major public health problem pakistan main cause violence seems anger frustration due poverty political conflicts lack education overall governance approach country therefore prime need think work neglected area like conducting research increasing public awareness media violence
application best estimate codes coupled neutron kinetics thermal hydraulics safety analyses research reactors gained considerable momentum past decade application codes largely facilitated high level technological maturity expertise codes allow safety technology nuclear power plants largely driven international atomic energy agency activities present study belongs framework presents development application coupled code thermo analysis protected reactivity insertion accidents loss flow accidents typical standard materials testing reactor plate type fuel elements coupling realized considering reactivity fuel coolant temperatures heat generation model reactor power neutron flux reactor core solved applying point reactor kinetic equations employing radial axial power distributions calculated three dimensional full core model continuous energy monte carlo reactor physics code evolution temporal spatial distributions fuel coolant temperatures calculated fuel channels using finite volume time implicit numerical scheme solving three conservation equation model study additional features critical heat flux ratio prediction decay heat model implemented highly enriched low enriched cores comprehensive comparison thermo results performed codes
introduction used caution older adults overactive bladder oab due anticholinergic adverse events aes systematic reviews meta analyses analyzed safety related outcomes specified risk elderly population highest risk aes aim review explore evaluate aes treatment adults older taking oab methods keywords searched medline embase scopus cochrane central register controlled trials randomized controlled trials rcts along sub analyses pooled analyses compared placebo another antimuscarinic performed february studies assessing aes treatment population adults older included criteria tool used assess quality trials results total studies met inclusion criteria eighty aes reasons treatment discontinuation described included studies explored anticholinergic aes common compared placebo incidence dizziness urinary retention headache urinary tract infections significantly higher compared placebo treatment discontinuation due aes dry mouth higher compared placebo older adults conclusions treatment overactive bladder using adults aged older resulted significant increases risk several aes compared placebo including anticholinergic non anticholinergic aes elsevier ireland ltd rights reserved
recent studies revealed memory enhanced information processed fitness related purposes main objective current experiments test developmental trends evolutionary foundation memory using different types stimuli paradigms experiment year olds adults presented neutral negative survival related drm word lists found memory benefit survival related words showed false memories likely elicited survival related word lists lists experiment examined developmental trends survival processing paradigm using neutral negative survival related pictures survival processing advantage found survival related pictures adults negative pictures year olds neutral pictures year olds experiment year olds adults standard survival scenario adapted survival condition condition designed reduce possibilities processing found superior memory retention survival scenarios children adults collectively results show survival processing advantage developmentally invariant certain mechanisms elaboration underlie developmental trends
research group working development active rotor control system incorporates mechanism blade pitch dynamic stiffness modulation root active pitch link system overcomes stroke limitations smart material superior performance rotor induced vibration reduction system tested tower facility article reports achievements obtained dynamically similar rotor blade model reduction transmitted loads occurred target frequency blade excited jet mimic asymmetric flow rotor forward flight open loop control algorithm optimized target higher harmonic frequency rotor also minimized impact rotor fundamental cyclic control frequency another experiment university semi passive control techniques using piezoelectric materials investigated aeroelastic control fixed flutter oscillations typical section controlled range airflow speeds finally similarity control techniques discussed recognized based dynamic stiffness modulation control principle
large urban become collection point many persons severe mental illness connections community mental health services needed assure care promote successful community living following release paper addresses issue individuals severe mental illness received community mental health services prior county year time period using unique linked administrative data source logistic regression used determine probability severe mental illness received mental health services function demographic clinical characteristics overall persons severe mental illness receive mental health treatment small statistically significant sex race differences observed received treatment psychiatric unit findings confirm central role mental health treatment emphasize need greater information sharing collaboration community mental health agencies minimize use facilitate successful community severe mental illness
aims determine prevalence glucocorticoid use adults diabetes whether prevalence associated reduced skeletal health measured fracture history use methods participants age years cross sectional national health nutrition examination survey diabetes determined self report fasting plasma glucose mmol mmol mol fractures use determined diabetes status glucocorticoid use logistic regression stratified sex assessed effect glucocorticoid use diabetes associated fractures results age standardized prevalence glucocorticoid use higher among persons diabetes without diabetes among adults diabetes prevalence fractures significantly higher among taking glucocorticoids fractures use generally similar without diabetes stratified glucocorticoid use logistic regression analysis among men combination diabetes glucocorticoid use compared neither highly associated use adjusting demographic factors among women diabetes glucocorticoid use increased odds fractures adjusting demographic factors menopause conclusions prevalence fractures greater diabetes taking glucocorticoids versus taking glucocorticoids study provides national framework research elucidating associations elsevier inc rights reserved
percutaneous image guided tumor ablation minimally invasive surgical procedure treatment malignant tumors using needle shaped ablation probe insertion needle using robot increase accuracy decrease execution time procedure extracting needle tip position ultrasound images paramount importance verifying needle approaching regions major vessels also used direct feedback signal robot needle method estimating needle tip previously developed combining modified transform image filters machine learning paper improves method introducing dynamic selection region interest images filtering tracking results using either kalman filter particle filter experiments biopsy needle inserted phantom robot conducted guided infrared tracking system proposed method accurately evaluated comparing estimations needle positions manually detected physician images results show significant improvement precision reduction percentile error compared previous automatic approaches method runs real time frame rate frames increased robustness accuracy make algorithm usable autonomous surgical systems needle insertion
given next generation networks expected large number devices need quick deployment evaluation alternative mechanisms cope possible generated traffic large scale distributed data networks sense popular network node choice due reduced size processing capabilities low cost support widely used operating systems information transport network coding new paradigm fast reliable data processing networking storage systems overcomes various limitations state art routing techniques therefore work provide depth performance evaluation random linear network coding based schemes models showing processing speed encoding decoding operations corresponding energy consumption results show several scenarios processing speeds model model moreover show processing energy per bit network coding even order magnitude less scenarios
criminal drug charges employment levels weekly hours recent substance use past months primary sources income examined among sample women offenders opioid use disorders without histories general linear model tested examine differences relation use history results one way found histories reported significantly higher levels drug charges without history significant differences terms weekly hours employment recent substance use observed groups women offenders histories reported various sources income beyond employment women reported primary source income findings suggest maintenance treatments sufficient meeting needs women offenders
ambient intelligence ami deals new world ubiquitous computing devices physical environments interact people ami environments diverse homes offices meeting rooms schools hospitals control centers vehicles stores sports facilities music devices paper present design implementation testbed ami using mounted analyze performance mean shift clustering algorithm considering sensing data evaluation considered respiratory rate heart rate metrics simulation results show mean shift clustering algorithm good performance
integrating direct write devices three dimensional printed parts key continuing innovation engineering applications smart material systems structural health monitoring however integration challenging printing techniques leave rough porous surfaces untreated thermal sintering process required conductive degrade polymeric materials printed parts extensive needed process layer layer fabrication cause weaker bonding create structural weak points challenges rather common insertion conductive patterns inside printed structures avoidance developed simple print method transfer device film onto layer printed object transfer achieved using self adhesion printing materials applying additional adhesive demonstrated method transferring jet printed strain sensors parts fabricated printing report provides investigation discussion sensitivity reliability influence embedding sensor mechanical properties
present study reports independent classic articles published american scientists examined articles cited least times since publication end using science citation index expanded web science also applied indicator index assess contributions authors articles results showed classic articles published productive categories multidisciplinary sciences biochemistry molecular biology general internal medicine science published articles three productive institutions university institute technology university author article written university highest number citations addition article university highest number citations
objective investigate efficacy safety outcomes combination therapy used optimize etanercept treatment patients psoriasis treated real life clinical practice methods data patients presenting psoriasis treated initially etanercept monotherapy analysed retrospectively patients subsequently treated combination therapy analysed psoriasis area severity index score recorded patients receiving subjective pain score recorded psoriatic arthritis receiving treatment thereafter month intervals results database patients treated etanercept patients male female mean age underwent combination therapy due lack efficacy patients received mostly short term range corticosteroids methotrexate anti inflammatory drugs significant reductions mean score baseline also significant reductions mean pain vas score baseline patients psoriatic arthritis drug survival rate mean duration etanercept treatment safety profile combination therapy satisfactory conclusions short term combination etanercept optimize treatment options improve long term drug survival patients psoriasis
solving boundary value problems shapes boundary modelled curves widely used computer graphics parametric integral equations system curves directly included mathematical formalism simplify way definition modification shape boundary now spline curves used recent developments computer graphics paid attention therefore implemented possibility defining shape boundary using curves curves allow modeling different shapes precisely paper compare solutions applied solutions existing literature
novel label free based nanoparticles nitrite groups synthesized simple one step chemical reaction first developed specific detection tumor marker liver cancer obtained nanoparticles nps characterized proton nuclear magnetic resonance spectroscopy nmr ray photoelectron spectroscopy xps ray diffraction xrd fabricated process investigated attenuated total reflection fourier transform infrared spectra ftir static water contact angles scanning electron microscope sem cyclic electrochemical impedance spectroscopy eis electrochemical performances studied results indicated prepared modified showed excellent electrochemical properties satisfactory accuracy detection real clinical samples attributed properties nps structure increase specific surface area unique chemical reactivity loading capacity protein molecules construction biosensors using structure properties molecules offer ideal electrode substrates provided possibilities design biosensor
cancer incidence patients recurrent venous thromboembolism much higher first event incidence myeloproliferative neoplasms mpn situation still unknown tested mutants dna samples patients treated among patients carrying mutation none calr mutations among patients recurrence vitamin antagonists patients positive despite identification mutation three patients diagnosed mpn despite median follow years showed screening calr mutations helpful indication especially recurrence happened therapy
introduction invasive fungal infection among leading causes morbidity mortality economic burden patients acute leukemia induction chemotherapy past decades incidence invasive fungal infection increased dramatically management complicated increasing frequency infection non aspergillus patients high risk developing invasive course high mortality rate case outline presenting case year old male acute leukemia patient treated five days day followed next days developed neutropenia headache edema right orbital region face computed tomography revealed shadow thickening mucosa right lavage revealed successfully treated amphotericin day followed day two months later patient died primary disease conclusion patients acute leukemia developed neutropenia pain fungal infection taken consideration new non invasive methods taking samples standardized order establish early accurate diagnosis source start early treatment proper antifungal drug clear communication physician critical ensure proper timely sampling lavage correct specimen processing suspected clinically
recent studies indicate immune system adaptation pregnancy play significant role pathophysiology perinatal depression aim study investigate inflammation markers late pregnancy plasma sample predict presence depressive symptoms eight weeks postpartum blood samples pregnant women median iqr days delivery days respectively comprising individuals postpartum depressive symptoms assessed postnatal depression scale mini international neuropsychiatric interview mini controls analyzed inflammation protein panel using multiplex proximity extension assay technology comprising inflammation associated markers summary inflammation variable also calculated logistic regression elastic net analyses implemented forty markers lower late pregnancy among women depressive symptoms postpartum difference remained statistically significant otherwise bonferroni correction summary inflammation variable ranked second best variable following personal history depression predicting depressive symptoms postpartum protein level findings validated relation methylation status loci respective genes different population using available data approach revealed differences late pregnancy levels inflammation markers women presenting depressive symptoms postpartum controls previously described literature despite fact results support use single inflammation marker late pregnancy assessing risk postpartum depression use novel notion summary inflammation variable developed work used combination biological markers future authors published elsevier ltd
construction safety management improvement aligned condition workplace aim research identify significant safety practices intervention levels improving behavioral safety performance workers construction industry literature review used identify determine relevance list safety intervention practices take place various levels total safety practices identified questionnaires measure level significant safety intervention practices towards positive behavioral safety performance workers targeted respondents safety personnel middle level personnel construction companies manage differ construction projects oil gas infrastructure building projects data collected least respondents analyzed using structural equation modelling sem determine significant safety practices intervention level first result references develop dynamic model integrated multilevel safety intervention practices construction industry findings expected useful guidance safety construction management order improve behavioral safety performance worker authors published elsevier ltd
magnetic damper introduced high speed rotating machinery vibration rotor supported active magnetic bearings experimental setup made one rotor two radial active magnetic bearings one axial active magnetic bearing one magnetic damper control system built investigate effects magnetic damper locations dynamic characteristics system theoretical analysis experimental modal analysis actual operation system results show vibration active magnetic bearing system operating modal frequency reduced effectively magnetic damper located far nodes corresponding mode shape
based fuzzy decision theory multi objective fuzzy optimization done three dynamic model scheme self anchored cable stayed suspension bridge combining fuzzy decision method engineering practice using two comparison theory solves problem quantifying qualitative indexes comparison results show reasonable place viscous main tower girder longitudinal displacement mid span girder time method provide reference structure selection practical conceptual design phase
natural phenomena simulation attracted research attention interest computer graphics virtual reality technology domains water one common phenomena real world acquisition modeling different water movements become one important research topics recent years paper design acquisition system capturing dynamic water surface also present image based method water surface reconstruction goal water surface reconstruction compute coordinates dynamic water surface
aim rna seq analysis recently identified nucleotide transcript upstream salmonella investigated molecular characteristics function materials methods race northern blotting used determine molecular characteristics sequence mutagenesis microarray immunoblotting invasion assay used investigate functions transcript results transcript identified untranslated region utr influence expression genes invasion hela cells deletion bax increased expression invasion genes invasive capacity whereas expression utr reduced expression bax conclusion utr reduces expression bax increases invasive capacity
geosynthetics proposed use method increasing bearing capacity soil medium reducing settlement study load settlement behaviour strip investigated experimentally numerically ultimate load centrally loaded model strip resting reinforced unreinforced sand determined plane strain conditions sand placed tank relative density obtain general shear failure numerical simulation experimental set carried using software woven geotextile used soil reinforcement material model utilised model sand load settlement curves obtained numerically using reinforcement caused increase ultimate load numerical simulations laboratory tests effect changes ultimate bearing capacity due load investigated using numerical analytical methods
middle east respiratory syndrome virus transmitted via respiratory tract causes severe acute respiratory distress syndrome infecting lung epithelial cells macrophages macrophages readily recognize virus eliminate cells via glycoprotein binds receptor present macrophages whether association affects macrophage responses remains unknown herein demonstrated infection macrophages particles glycoprotein results suppression macrophage responses since reduced capacity macrophages produce naive lps activated macrophages augmented lps induced production immunosuppressive cytokine glycoprotein induced expression negative regulator signaling transcriptional ppar gamma inhibition inhibitor sirna abrogated effects glycoprotein ppar gamma confirming immunosuppressive effects mediated receptor effect observed macrophages human primary peripheral blood monocytes findings support mediated suppressive action macrophages suggest potential target effective elimination pathogenicity
lot research done improve fatigue strength materials creating compressive residual stress field surface layers shot present work found relaxed residual stress field varies shot intensity affects weight spring steel leaf springs stress approach model weight reduction leaf springs used automotive vehicles experimentally developed simulating industrial environment paper discusses time saving reliable method predicting thickness weight leaf springs various shot intensities industrial applications model based experimental results developed predicts weight reduction leaf springs given stress varying shot conditions authors published elsevier ltd selection peer review responsibility american applied science research institute
despite multiple risk factors mortality among people drugs research warranted examines sub populations within mortality data participating longitudinal hiv prevention research obtained department public health environment risk factors cause acute toxicity related mortality analyzed using cox proportional hazards regression two thousand seven individuals interviewed baseline eighty six individuals died time frame study due acute toxicity disabled gay lesbian identified white race ethnicity use shared important adjusted risk factors suggest drug hiv interventions utilize techniques address needs populations addition hiv drug risk behaviors
demonstrated increase glutamate cultured cerebellar cells rat pups subjected lead poisoning prenatal development early lactation period toxic effect glutamate weaker lead applied combination antioxidant acid data discussed view practical use acid therapy brain tissues subjected lead poisoning
laser cutting advanced processing technology according computer aided design graphics cut variety shapes surfaces many polymer sheets work aims analyze effect laser power scanning speed processing times surface roughness laser cutting process several experiments designed results analyzed orthogonal experimental method finally optimal power scanning speed processing times obtained optimal case mean roughness reach small
shallow coastal areas lakes pose significant remote sensing challenges due transient nature features characterize areas data maps often represent areas white zones sparse data coverage presents particular challenge defining sustainable use marine resources given need cost efficient methods producing high resolution maps shallow areas research described compares airborne light detection ranging lidar acoustic surveys around northern sea includes unique shallow water marine environment number landscape area characterised fields like combined ongoing typical area lead elevated structures land present structures rise land future ongoing modification environment climatic forces contributes complex ecological feedback systems operating range spatial temporal scales airborne lidar provide high resolution remote sensing data shallow coastal areas technology especially effective areas waters like found along finnish coast lidar enables continuous detection topographic elevation depth data thus generate continuous maps transition zones marine areas environmental conditions water clarity ice cover affect lidar depth detection capabilities conditions require complementary accuracy assessment strategies lidar determine detailed information surface substrate subsurface substrate type geological conditions determined application acoustic seismic methods sediment sampling underwater video data lidar surveys provide detailed topographic map study area water depths model shows series elevated narrow features appear throughout study area parallel represent features interpretation acoustic surveys indicates general orientation differs associated older features northern older high angle younger study area thus represent two phases finally ice sheet ice edge combined approach using lidar acoustic data provides new insights past dynamics published elsevier
photo fundamental surveys address different topics gravitational dark matter distribution evolution degree survey european southern public survey survey provides unprecedented opportunity exploit large data set exceptional image quality depth optical using subset measured spectroscopic derived photo using three different empirical methods based supervised machine learning bayesian model iii classical spectral energy distribution template fitting procedure confirm regions parameter space properly sampled spectroscopic templates machine learning methods provide better estimates lower smaller fraction outliers fitting techniques however provide useful information spectral type effectively used constrain systematic errors better characterize potential catastrophic outliers classification used training regression machine learning models demonstrating hybrid approach involving fitting machine learning single collaborative framework effectively used improve accuracy photo estimates
reproductive history exogenous hormonal exposures acknowledged risk factors breast cancer general population women increased breast cancer risk genetic predisposition positive family history data regarding risk factors limited conflicting recommendations categories unclear evaluated characteristics reproductive life women increased genetic familial breast cancer risk attending family cancer center breast cancers mutation carriers likely hormone receptor negative diagnosed years multiple lifetime tumors women increased familial risk distribution invasive cancers positive tumors similar different risk groups least one pregnancy breastfeeding either less one year late age menopause showed protective factors mutation carriers women increased familial risk early age first full term pregnancy late showed main protective factors finally entire population combined hormonal contraceptives demonstrated increase breast cancer risk results study suggest women high familial risk mutation carries develop tumors different clinical pathological characteristics consequently influenced different protective risk factors
two part paper topological analysis collecting vehicles based simulation different architectures internal combustion engine hybrid electric hybrid hydraulic real routes proposed second part three different hybrid electric powertrain architectures proposed modeled architectures based use fuel cells batteries calculation engine specifically designed estimate energy consumption original performance original internal combustion engine ice presented used simulations component sizing finally overall performance different architectures hybrid hydraulic taken first paper part hybrid electric estimated second part control strategies summarized fuel energy consumption table based table analysis different architecture performance results carried analysis technological evolution vehicles medium long terms proposed
ubiquitous literature popular discourse yet little known cognitive representations examined lay conceptions using prototype approach compared persons influence studied individuals use features identify study participants generated open ended descriptions sorted independent meaningful categories study participants rated centrality features subsequently classified feature either central moral integrity peripheral proactive reaction time paradigm participants study identified central features faster peripheral features study participants remembered central features peripheral features recall task study participants strongly identified target described central features peripheral neutral features studies participants ratings evidenced prototypical features fit conceptually role models leaders studies contribute new ideas existing knowledge contribute shared understanding means people research thus important step refining scientific concept notion prototypical features provides basis future research intervention
motions suspension bridge immersed turbulent wind flows including mean stochastic certain conditions lead degradation structures torsional stiffness aerodynamic torsional divergence main cables determines effectiveness supporting members limited tension state either one cable tension state result torsional stiffness contributed whole cable system although physical conception quite explicit evaluation critical threshold suspension bridge experiencing stochastic aerodynamic responses complicated deformations towers lateral oscillations deck cables high order modes participating vibration view criterion based tracking length main cables presented study shown numerical example advent degradation systems stiffness striking post behaviors explained proposed model tracking cable lengths elsevier ltd rights reserved
production one biggest solid state fermentation industries world success depends control temperature humidity parameters paper presents novel method modeling environment growth comparing performance two controlling methods fuzzy logic digital control controlling mentioned parameters production rate controllers equipment developed data collection analysis parameters performed using simulink part matlab software precise control parameters involved growth caused improve product quality reduced energy consumption results tests mean value obtained two different methods showed fuzzy controlling least standard deviation variance error better digital controlling fuzzy controlling system lowest fluctuation lowest band pass according gradient graph maximum minimum results conclude fuzzy controlling shown better response controlling process based number actuators mode changing systems understood digital control system energy consumption higher fuzzy control system elsevier ltd rights reserved
aim paper develop two three dimensional stability charts slopes susceptible translational failure extensive parametric study conducted using slope model designed simulate field conditions respect configurations sliding mass unit weight shear strength involved materials slopes subjected different conditions pore water pressures seismic forces considered study study shows special importance difficulties considering end effects analysis translational slope failures suggests method quantifying incorporating charts presented paper require iterative procedure determining factor safety give practicing geotechnical engineer fast reliable method estimate two three dimensional factors safety slopes susceptible translational mode failure back calculate shear strength materials involved slope failures following mode numerical examples given illustrate different uses charts
sexual gender norms promoting sexual men sexual women shown negatively affect sexual mental health men women knowledge relationship gender norms sexual cognitions emotions understanding continued gender norm present study investigated whether gendered sexual attitudes related positive negative sex related emotions via sexual cognitions autonomy body esteem approach avoidance motives sex survey submitted identified sexually active dutch central southern regions year olds results moderated mediation model using structural equation modeling revealed women men strongly endorsed traditional gender related sexual attitudes experienced significantly less positive negative emotions result decreased sexual autonomy sexual body esteem increased avoidance motives sex conclude result negative cognitions associated endorsement traditional gender norms women particular risk experiencing negative emotional outcomes sexual context argue sexual cognitions emotions deserve explicit attention sex positive gender sexuality education proven vital resource achieving increased gender equity sexual romantic relationships
deposits formed specific lake deposition environment period characteristic bearing stratum containing composed binary structure mineral deposition occurred late deposition period usually associated clay formed deposits characteristics low density low electrical according characteristic deposits employ comprehensive technology exploration firstly conducted high precision gravity survey area obtain gravity anomalies processing analysis gravity data got access fault structures development gravity anomaly changes study area deduced spatial variation characteristics underground delineated favorable mining area deposits based audio carried favorable area electrical structure characteristics underground study area obtained combining seismic electric fitting electrical data joint inversion gravity electricity data geological data study area analyzed stratum structure fracture system distribution relation deposits predicted distribution deposits drilling test results basically consistent predicted results
study aimed evaluate variation following parameters rotation motor pump set power developed electric motor reduction energy consumption pumping set center irrigation system operating two programming levels frequency inverter three positions operation experimental design completely randomized made three tested position applied analysis variance followed test two operation conditions tested test constant pressure output motor pump set test variable rotation accordance need pressure system condition operation tested three positions lines collecting level slope results showed lateral line position significantly influenced rotation motor pump set consequently power developed engine power consumption mainly test condition showing frequency inverter operating mode
vertical slot structures facilitate energy dissipation using specific pool slot design structures common west china develop effective simple design flow patterns pools fish friendly assist design optimisation three dimensional computational fluid dynamics cfd model experimental study validating model using equivalent scale physical model conducted paper presents results detailed hydraulic structures including velocity fields flow patterns flows turbulent structures pool conditions slopes new structure long shaped new structure effectively improve flow patterns fish adopting burst coast mode mainstream velocity decreases average proportion recirculation region decreases compared slope creates omega shaped flow pattern results provide insight flow patterns vertical slot used guide future designs international association hydro environment engineering research asia pacific division published elsevier rights reserved
solar radiation data critical design operation solar energy utilization systems large number models proposed developed estimate solar radiation past ten years however performances models controversial different studies lack systematic comparison among addition studies pay attention time scales models paper focuses solving questions critical literature review authors believe benefit researchers perform investigations solar radiation paper reviews compares models points view time scale estimation type first time furthermore large amount data evaluation metrics root mean square error mean absolute percentage error different studies summarized clarify performances proposed models questions arising processing source data also carefully examined paper presented novel method compare estimation models provided detailed analysis available models results indicate duration fraction models artificial neural networks similar performances used estimate monthly average daily global radiation daily global radiation work needed study estimation method smaller time intervals mechanisms atmospheric attenuation solar radiation
tof one common forms congenital heart disease usually managed serial surgical prosthetic valve susceptible life threatening infection fdg pet effective alternative evaluate source infection examinations inconclusive report unusual case infected pulmonary artery tof repair although negative vegetation later confirmed surgery pathology case highlights role fdg pet problem solving tool potential cardiac device infection cases complex cardiac surgery
background early life exposure household capacity reduce risk overweight allergic disease especially following delivery since evidence also alter gut microbial composition infants changes gut microbiome putative pathways pet exposure reduce risks health investigate impact pre postnatal pet exposure infant gut microbiota following various birth scenarios study employed large subsample infants canadian healthy infant longitudinal development study child cohort whose mothers enrolled pregnancy participating mothers asked report household pet ownership recruitment second third trimester months postpartum infant gut microbiota rrna sequencing faecal samples collected mean age months two categories pet exposure pregnancy pre compared pet exposure different birth scenarios results half studied infants exposed least one pet prenatal postnatal periods exposed pregnancy alone exposure time periods common effect birth scenarios pre postnatal pet exposure enriched abundance twofold greater likelihood high abundance among born infants maternal antibiotic prophylaxis exposure substantially significantly reduced pet exposure reflecting decreased likelihood high abundance pet exposure pregnancy alone reduced likelihood exposure pre postnatal time periods associations independent maternal asthma allergy status breastfeeding home characteristics conclusions impact pet ownership varies different birth scenarios however common exposure increased abundance two bacteria negatively associated childhood atopy obesity
background ability recognize respond appropriately threat critical survival neural substrates attention threat using media violence whether neural responses potential threat differ syndrome known methods performed functional mri scans adolescent adult syndrome typically developing individuals group matched age gender min passive viewing brain activation auditory visual features violence presence antagonist compared across segments fmri signal brains dorsal attention network compared thematic violent events within syndrome control samples results found typical development brains dorsal attention network active violent scenes significantly specifically reduced syndrome antagonist screen significantly less activation left medial temporal lobe individuals syndrome scenes represented greater relative threat disparity attentional brain activation syndrome control individuals increased reduction temporal dorsal attention network consistent shortened attention span syndrome individuals syndrome exhibited significantly reduced activation primary sensory cortices perceptual impairments constrain ability respond complex social cues violence conclusions findings indicate relative deficit perception violence syndrome possibly mediated impaired sensory perception medial temporal structures response threats relative preservation activity pro social brain regions findings indicate specific genetic differences associated syndrome modulate brains response violence complex ideas
present paper shows innovative unmanned aerial vehicle uav able easily quickly change configuration order satisfy feature principal structure made universal plate combined circular ring create rail guide able host arms variable number legs arms adjustable contain motor drivers connect main structure electric motor unique arm design defined one allows classical single rotor configurations double rotor configurations configurations including elements positioned bottom arms proposed multi rotor system inexpensive universal pieces needed platform allows creation kit modular kit allows modular different configurations configurations distinguished among number arms number legs number rotors motors landing capability another innovation feature introduction printing technology produce structural elements manner pieces designed produced via fused deposition modelling technology using desktop therefore universal dynamic economic multi rotor uav developed
photocatalytic reduction carbon dioxide one pathways involved carbon dioxide conversion process receiving significant attention scientific community last four decades nevertheless mechanism carbon dioxide reduction still unclear information available sufficient developing large scale applications possibly associated reduction process photocatalytic conversion involves redox reactions occurring interface semiconductor water splitting hydrogen evolution oxygen evolution photo oxidation reactions reactions radical intermediates overall product yield highly dependent extent competing reactions herein discuss perceptions current status interface reactions involvement fundamental mechanistic aspects photocatalytic conversion
cognitive reserve shows protective effects alzheimers disease reduces risk dementia despite clinical significance clinically useful diagnostic biomarker brain changes underlying available yet aim develop fully automated approach applied fmri produce biomarker associated subjects increased risk computed resting state global functional connectivity average connectivity strength voxel within cognitive control network sustain due central role higher cognitive function training sample including mild cognitive impairment mci subjects healthy controls found mci subjects high median years education showed increased frequency high values compared mci summary index capturing frequency high computed called reserve index discriminated mci mci area roc cross validation independently recruited test sample mci subjects showed higher levels index predicted higher years education alternative questionnaire based proxy controlled memory performance gray matter cognitive control network white matter age gender conclusion index captures changes within cognitive control network provides biomarker candidate functional brain changes patients increased risk
objectives purpose examine relation social risk factors cumulative burden social risk factors parent reported dental health dental care seeking behavior methods national survey childrens health data analyzed children title block regions multivariate logistic regressions estimated ten social risk factors cumulative risk index find associations poor condition teeth presence dental dental care visits results almost risk factors significantly associated poor condition teeth presence dental models dental care visits suggested low family income poor maternal mental health high school education less multi racial race significant factors regional variation existed risk factors association outcomes income education poor maternal mental health consistently played significant role adverse outcomes cumulative risk index strongly related poor oral health outcomes weaker relationship dental care utilization conclusions practice children experiencing certain social risk factors low family income high school education less poor maternal mental health likely greater risk poor dental health low levels dental care seeking behavior children experiencing multiple social risks greater risk poor oral outcomes children experience fewer social risks approach involves social determinants health needed address issues
study introduces efficient procedure estimate structural response suspension bridge real time based limited set measured data unlike conventional techniques proposed procedure employ mode shapes frequencies study proposed technique used estimate response suspension bridge structure based set strain gauge measurements finite element analysis performed set structural parameters namely computed flexibility matrix computed forces matrix response bridge estimated without additional finite element analysis using computed structural parameters measured strains bridge california selected study high fidelity finite element model bridge developed using general purpose computer program proposed method proven capability estimate type structural response real time based measured strains provides important part integrated structure health monitoring shm system major bridges
seismic images composed positive negative seismic wave traces different amplitudes seismic imaging review techniques principles merits limitations association amplitudes together color forms complex visual patterns color intensity patterns directly related impedance contrasts higher contrast higher color intensity generally speaking low impedance contrasts depicted low tone colors creating zones different patterns whose features evident automated mapping option available commercial software work workflow semi automatic mapping seismic images focused areas low intensity colored zones associated petroleum interest proposed color space used perform seismic image processing helped find small significant differences pixel process generated binary bound color regions low intensity colors three projection allowed construction structures zones proposed method applied set digital images seismic tested four representative study cases obtained results encouraging interesting obtained minimum information
presence defects modifies stiffness strength materials also changes morphologies latter effect extremely significant low dimensional materials graphene show work graphene point defects mono created finite concentrations distorted geometry resulted expansion combination plane effect predicts unusual defect concentration dependence stiffness measured supported graphene membrane tests leads defect induced phenomenon mechanism elucidated analytical membrane model numerical simulations continuum levels addition elucidate counter intuitive observations experiments computer simulations findings also highlight role defect modulated morphology engineering applied design nanoscale material structural applications elsevier ltd rights reserved
ontologies becoming popular knowledge representation methods particularly areas semantic web smart environments paper focuses design user behaviour ontologies ambient intelligence ami environment using ontology creation tool sensors installed environment users behaviour sensed stored devices environment stored behaviour data refined formed temporal sequence ontology constructed mapping relations behaviour related temporal sequence work demonstrated different ways representations advantage approach makes cognitive support easier teachers
parents children attention deficit hyperactivity disorder adhd oppositional disorder odd often elevated adhd depressive symptoms increase risk ineffective parenting however little known whether child adhd odd behavior parent adhd depressive symptoms uniquely synergistically predict quality parenting communication mother father child interactions ninety parent couples including children diagnosed adhd randomly assigned interact year old child male exhibiting either adhd odd like behavior typical behavior parents reported adhd depressive symptoms parents observers rated quality parenting communication interaction actor partner interdependence modeling indicated child adhd odd behavior predicted less positive negative parenting communication independent adult adhd depressive symptoms parent couples including two parents elevated adhd communicated positively managing children exhibiting adhd odd behavior couples managing children typically couples one parent elevated adhd symptoms couples including one parent one parent without elevated adhd depressive symptoms less positively negatively communicated negatively managing children exhibiting adhd odd behavior managing children typically taken together depending similarity adhd depressive symptom levels parent couples adults managing children exhibiting adhd odd behavior parent communicate positively negatively findings highlight need consider psychopathology parents treating children adhd two parent homes
malignant tumors head neck carcinomas sixth common type cancer current systemic therapies cancer show side effects normal tissues short term efficacy due drug resistance consequently much interest identifying new drugs cancer treatment active ingredient shown cytotoxic effects cancer cell lines radiotherapy standard treatment head neck cancer present study cytotoxic effects inducing apoptosis radiation sensitivity evaluated head neck cancer cell line cells cultured medium incubated different concentrations exposed gamma rays cell viability quantified mtt assay apoptotic cells determined using staining dna fragmentation sub peak decreased cell viability cells time concentration dependent manner also induced sub peak histogram treated cells compared control suggesting apoptotic cell death caused toxicity also shown cells radiation induced toxicity apoptosis simultaneous use radiation therefore increases radiation sensitivity cell death thus study considered potential drug cancer treatment
aims ligands vitamin receptor regulate apolipoprotein gene expression tissue specific manner vitamin metabolite shown possess unique biological effects determine modulates gene expression hepatocytes intestinal cells treated precursor main methods protein levels mrna levels measured western northern blotting respectively changes promoter activity measured using assay key findings treatment inhibited secretion cells mrna levels promoter activity cells determine gene expression site nuclear receptor binding element essential effects gene expression cells transfected plasmids containing lacking site site containing plasmid suppressed plasmid lacking site likewise treatment suppressed reporter gene expression cells transfected plasmid containing site front promoter finally antisense mediated depletion failed reverse silencing effects expression significance results suggest vitamin metabolite endogenous regulator synthesis independent signaling mechanism elsevier inc rights reserved
paper presents new single phase cascaded multilevel link inverter proposed inverter comprises two stages main stage inverter consists multiple similar cells half bridge inverter consisting two switches single source cells connected cascaded manner fixed neutral point source values made equal increase performance inverter second circuit folded cascaded bridge circuit operating line frequency one main advantages proposed topology modular type thus extended high stages without changing configuration main stage circuit two control schemes namely low switching selective harmonic elimination sinusoidal pulse width modulation employed validate proposed topology detailed approach control scheme switching pulses discussed detail prototype proposed system implemented laboratory verify validity proposed topology
resistance broad spectrum animals become great concern public health estimate dissemination resistant bacteria dog human examined resistance determinants genetic similarities resistant escherichia coli isolates derived canine rectal human clinical samples coli isolates possessed tem canine human isolates human isolates canine human isolates canine human isolates canine human isolates type beta significantly frequent human isolates whereas common canine isolates bacterial typing methods phylogenetic typing antigen pulsed field gel electrophoresis showed little clonal relationship canine isolates human isolates plasmid analysis southern blotting indicated plasmids encoding similar among canine human isolates based differences major beta divergence bacterial types canine human isolates seems clonal dissemination resistant coli humans limited similarity encoding plasmid suggests plasmid mediated beta gene transmission plays role diffusion resistant coli dog human japanese society chemotherapy japanese association infectious diseases published elsevier ltd rights reserved
although many aspects ovarian differentiation established comparatively little known prenatal follicle formation differentiation bovine ovaries objective investigation study role surface epithelium development germ cell germ cell follicle formation fetal bovine ovary associated important proliferation apoptotic features investigated additionally expression pattern protein detected strong increase figures detected surface epithelium germ cell germ cell ovaries crown length positively stained bovine ovaries fetuses staining intensity enhanced parallel increasing follicle sizes ovary development later stages strong staining observed healthy expression protein found conclusion increasing index surface epithelium cells directly surface epithelium combination open surface connection stages bovine fetal ovaries play important role period time ongoing derivation cells additionally positive later follicle stages high rate positive index surrounding cells indicate protein perhaps useful marker intact bovine ovaries copyright karger basel
paper dimensional nonlinear evolution equation investigated used describe mixtures shallow water waves hirota method symbolic computation bilinear forms backlund transformation derived different existing literature moreover shock wave solutions obtained based shock wave solutions propagation collision shock waves discussed via asymptotic graphic analysis different planes elastic collisions among two three shock waves arise planes parallel elastic collisions exist plane shock waves maintain original directions amplitudes velocities except small phase shifts collision shock wave higher amplitude faster moves across slower
clustered regularly short repeats associated protein system provides technological breakthrough mutant generation several methods polymerase chain reaction pcr restriction enzyme assay assay assay page based genotyping assay high resolution melting analysis based assay developed screening induced mutants however methods time labour intensive also sequence limited require expensive equipment described cost effective sensitive screening technique based conventional pcr annealing critical temperature pcr act pcr identifying mutants act pcr requires single pcr step followed gel electrophoresis demonstrated act pcr accurately distinguished induced mutants wild type rice zebrafish moreover method adapted accurately determining mutation frequency cultured cells simplicity act pcr makes particularly suitable rapid large scale screening induced mutants plants animals copyright institute genetics developmental biology chinese academy sciences genetics society china published elsevier limited science press rights reserved
investigation paper dimensional variable coefficient generalized shallow water wave equation bilinear forms backlund transformation lax pair obtained based bell polynomials symbolic computation one two three soliton solutions derived via hirota method one periodic wave solutions obtained via hirota riemann method discussions indicate one periodic wave solutions approach one soliton solutions propagation interaction soliton solutions discussed graphically find soliton amplitudes velocities related variable coefficients phase shifts two soliton solutions differences superposition two one soliton solutions amplitudes two soliton solutions equal sum corresponding two one soliton solutions
aim purpose study examine clients perspectives regarding helpful aspects therapy depression method thirty nine clients received psychological treatment multi site study exploring alternative interventions standardised evidence based approaches eighteen face face telephone change interview end treatment change interviews aim elicit clients perspective regarding changes noticed therapy also possible causes changes descriptions transcribed analysed thematically using explicit coding themes research team findings data three priori domains consisting specific themes first domain constitutes client originated helpful factors including clients positive perspectives therapy clients overall effort change clients contribution decision making process therapy therapists perceived helpful accepting empathic responding clients needs making clients feel comfortable challenging empowering using techniques flexible treatment outcomes change perspectives behaviour response problems increased insight also considered helpful factors therapy conclusion findings suggest clients therapy active agents change willingness engage treatment crucial helping clients feel comfortable creating safe therapeutic environment challenging dysfunctional patterns associated depression empowering believe change possible non intrusive guidance considered beneficial
mesenchymal cells intestine comprise variety cell types diverse origins functions molecular markers provide mechanical structural support important functions intestinal morphogenesis homeostasis recent studies human transcriptome revealed importance development colorectal cancer studies animal models provided evidence roles pathogenesis colitis associated cancer sporadic colorectal cancer mesenchymal cells tumors called cancer associated fibroblasts arise via activation resident mesenchymal cell populations recruitment bone marrow derived mesenchymal stem cells cancer associated fibroblasts variety activities promote colon tumor development progression include regulation intestinal inflammation epithelial proliferation stem cell maintenance angiogenesis extracellular matrix remodeling metastasis review intestinal mesenchymal cell specific pathways regulate processes focus roles mediating interactions inflammation carcinogenesis also discuss increasing understanding intestinal mesenchymal cell biology function lead new strategies identify treat colitis associated cancers
spain need improve chronic hepatitis care among people drugs drug use important risk behaviour hepatitis virus hcv infection review sources relevant published literature mapped size addiction hcv population spain experts opioid use disorder treatment spain completed consensus define population size hcv prevalence access barriers hepatitis treatment populations spain individuals lifetime history drugs currently individuals spain many injected drugs year individuals engage treatment services proportion group continues drugs high hcv prevalence estimates spain uptake hepatitis therapy spain limited barriers include awareness treatment pathways advocacy regular screening effective joint care urgent need address barriers effective hepatitis care spain practical specific strategies including peer led solutions patient systems joint working models local level make important short term differences copyright wolters kluwer health inc rights reserved
recent years superior accuracy maternal plasma cell free dna based prenatal screening resulted national decline sampling creating new implications specialist training objectiveto compare annual figures tertiary hospital national population based trends study examining procedures performed tertiary hospital numbers procedures indications testing type test diagnostic results analysed trends annual numbers procedures compared national population based data medicare benefits schedule database resultsthe annual numbers diagnostic procedures tertiary centre fell study period representing decline significantly smaller corresponding national decline period ultrasound abnormality including high risk screening results common indication invasive testing thirty percent procedures performed ultrasound abnormality occurred prior gestation tertiary centre experienced relatively smaller decline prenatal diagnostic procedures compared national figures largely due increase testing ultrasound abnormalities results demonstrate increasing contribution first trimester ultrasound detection fetal abnormalities cell free dna era continued viability specialist training invasive procedures
paper presents method determination minimal stable fractional continuous time linear system different fractional orders proposed method based algorithm constructed paper shown perform transfer matrix using electrical circuits consisting resistances source voltages proposed method discussed illustrated numerical examples
six experiments involving total participants conducted investigate relative effectiveness repeated evaluative exposure category members paired images evaluative statements signaling upcoming without actual exposure combination shifting implicit social attitudes learning modality varied participants implicit attitudes assessed using implicit association test study used social groups study used novel social groups humans long square faces study used stimuli squares study study used known social groups young elderly american foreign effective less superior producing implicit attitude change results robust across social domains known novel groups study eliminated time intervention levels expectancy effects possible explanations findings associative theories implicit evaluation implicit attitudes shift time yet experiments one shot language based learning led larger shifts implicit attitude exposure stimulus moreover redundancy observed suggests attitude acquisition repeated evaluative instructions rely shared mental representations
internal model control based pid controller widely used industrial control problems scheme provides good compromise among set point tracking disturbance attenuation robustness therefore paper propose simple technique design pid controller illustrate utility proposed technique different types linear nonlinear second order systems approximated second order models higher order systems simulated proposed approach quick response set point change good disturbance attenuation optimal performances class problems compared conventional pid existing popular techniques paper need highly complex mathematical approaches using simple conventional approach improved servo regulatory results achieved
purpose review atp citrate emerged drug target ldl cholesterol ldl lowering review therapeutic strategy genetics molecular cellular biology also inhibition recent findings critical enzyme linking glucose catabolism providing acetyl coa mitochondrial citrate fatty acid cholesterol biosynthesis human genetic variants associated enhanced growth survival several cancers attenuated plasma triglyceride responses dietary fish oil mice liver specific deficiency protects hepatic dyslipidemia whereas adipose tissue specific deletion phenotype supporting therapeutic inhibition lipid regulating compound acid discovered inhibit animal models prevents dyslipidemia attenuates atherosclerosis phase clinical trials revealed acid effectively lowers ldl monotherapy combined added therapy patients summary efficacy acid ldl lowering agent validated inhibition therapeutic strategy positive results phase patient studies together long term cardiovascular disease outcome trials required establish major new target cardiovascular medicine
global drive low carbon dioxide environment secure affordable energy supply encouraged nuclear power play core role energy mix landscape today houses eight large nuclear plants reactors reported generate electricity two thirds electricity generation capacity need replaced low carbon dioxide reliable power future improve energy security meet carbon dioxide emissions targets cumulative growth nuclear capacity forecast comparison coal oil gas still leaving nuclear share global capacity considerable scope nuclear long term
shift scenario proposed model explain response cold adapted organisms climatic fluctuations europe north america however shift model explored eastern asia complex northern hemisphere regions evaluated role shift closely related temperate china typical trees sensitivity climate change tested shift hypothesis china using methods ecological niche models analyses comprised mitochondrial polymorphisms surveyed across individuals populations representing species inferred haplotype distribution results survey revealed multiple centers genetic diversity distinct geographic regions trend moreover results showed range expansions seven taxa last consistent fossil record china taken together findings support historical pattern expansions probably lower elevation isolation higher elevation peaks therefore china probably undergoes shift response climate change facing forecasting global warming risk several critically enhanced species little escape space situ higher according proposed situ conservation strategy southern region south western china
introduce algorithms conceptual circuits nonlinear differential outline methodology use mitigate band noise interference especially man made origin affecting various real complex vector signals interest limiting performance affected devices services given frequency linear filter affects noise signal interest linear filter used suppress interference outside interest resulting signal quality invariant type amplitude distribution interfering signal long total power spectral composition interference remain unchanged linear filter converted introducing appropriately chosen feedback based nonlinearity response filter reduce spectral density particular types signal without significantly affecting signal interest result signal quality improved excess achievable respective linear filter behavior filter degree nonlinearity controlled single parameter manner enables significantly better overall suppression noise compared respective linear filter especially noise contains components origin adaptive configurations similarly controlled single parameter suitable improving quality non stationary signals time varying noise conditions designed fully compatible existing linear devices systems used enhancement low cost alternative state art interference mitigation methods
current industrial practice thousands industrial alarms generating millions alarm events built digital control systems typically found power generation facilities power grid communication networks oil plants manufacturing plants given increasing complexity systems effective approach managing alarms stream data generate becomes imperative hitherto much alarm management techniques mostly rule based intensive engineering domain expertise requiring understanding underlying physical processes special skills part plant operator paper describes novel graph based data mining approach used analyze industrial alarm data method leverages availability large historical alarm events datasets using historical datasets developed graph analytics model identifies redundant alarms series alarms associated leading critical events experiments using real world power generation station oil industrial alarm datasets demonstrate proposed method scalable efficient
autonomy adaptability key features intelligent agents many applications intelligent agents control ambient intelligence environments autonomous intelligent robotic systems require processing information coming many available sensors produce adequate output responses changing scenarios autonomy cases applies ability agent produce correct outputs without human guidance also portability low power consumption sense embedded electronic system implementation paradigm applied design autonomous intelligent agents order satisfy mentioned characteristics however processing complex computational intelligence algorithms tight delay constraints resource constrained low power embedded systems challenging engineering problem paper single chip intelligent agent based computationally efficient neuro fuzzy information processing core described system information preprocessing module based principal component analysis pca permits substantial reduction input space dimensionality little loss modeling capability moreover pca module tested means achieve deep adaptability changing environment dynamics agent fault tolerance presence sensor failures data driven trials research data set obtained experimental intelligent environment used benchmark system elsevier rights reserved
organisms avoid threats fungal infections responses instead rely strategies reduce impact threats one strategy development hard structures minute calcium skeletal elements located top within tube walls multiple roles including structural support colony protection role physical barrier fungal infection however unknown study examines potential role sea fan protection fungal infection accomplish four different fungi isolated healthy sea inoculated tubes filled culture media healthy diseased placed top determine whether chemical compounds impact infection healthy diseased extracted several days prior inoculation results showed layer delayed fungal infection reaching agar compared controls tubes agar difference tubes healthy diseased differences among extracted study suggests addition roles structural support play role physical chemical barriers fungal infection elsevier rights reserved
fluid flow along semi infinite plate small periodic surface considered large reynolds numbers boundary layer double deck structure thin boundary layer lower deck classical boundary layer upper deck aim paper prove existence uniqueness stationary solution type equation describes oscillations vertical velocity component classical boundary layer
current research tested utility responsible gambling tool provides players personalized behavioral feedback play hypothesized players estimated monetary loss less actual monetary loss subsequent expenditures reduced end players enrolled based program asked much lost three month period whilst using card provided player account data results indicated players estimated losses lost money thought time perceive reduced play month follow period however data actual play indicated significantly reduced amount amount lost follow period given informed decision making responsible gambling tools results suggest providing players accurate information much spend gambling moderate gambling expenditures authors published elsevier ltd
phthalate member phthalate family used chloride chemical known enhance airway inflammation induced asthma model adjuvant effects allergic dermatitis moreover enhances production interleukin activated cells however effect differentiation naive cells helper cells vitro allergic asthma vivo yet studied study shown suppress polarization enhance polarization naive cells vitro also induced allergic asthma via production ige reduction ifn gamma finally confirmed exposure induces infiltration inflammatory cells positive cells increases expression caspase caspase asthmatic mice conclusion suggest environmental pollutant endocrine induces asthma via modulation equilibrium production mediated cytokines immunoglobulin elsevier rights reserved
studies intensive suggest fulfilling societal expectations good mother maternal psychological however studies tend focus young mothers examine association intensive psychological using sample mothers drawn national survey development united states intensive measured provision high levels emotional support children high degree thought effort put relationships reduction paid work provide care psychological measured depressive symptoms self rated mental health positive negative affect ordinary least squares regression results mixed providing high levels emotional support predicts depressive symptoms worse self rated mental health higher negative affect higher investments thought effort predict better mental health
chronic inflammation tumor microenvironment antitumor effector immune response two emerging hallmarks required cancer progression innate immune system plays critical role tumor promoting hallmarks also developing antitumor adaptive immune responses thus understanding dual role innate system cancer immunology required design combined immunotherapy strategies able tackle established tumors review recent advances understanding role cell populations soluble components innate immune system cancer focus complement molecule interferon genes natural killer cells myeloid cells cells
aims effective medication treatment refractory schizophrenia however descriptions mental health comorbidity profile care experiences people routine clinical settings scarce using data australian survey high impact psychosis aimed examine proportion people using compare users antipsychotic users demographic mental health adverse drug reaction treatment satisfaction variables methods data describing people diagnosis schizophrenia disorder reported taking antipsychotic medication previous weeks drawn representative australian survey people psychotic disorders contact mental health services previous months compared participants taking taking antipsychotic medications range demographic clinical treatment related indicators results one quarter participants participants chronic course illness one third adjusting diagnosis illness participants taking significantly lower odds current alcohol cannabis drug use despite similar lifetime odds metabolic syndrome diabetes common among people taking chronic pain less common psychotropic differ groups conclusions consistent international evidence large number participants chronic illness high symptom burden taking lower probabilities current substance use chronic pain among users warrant study
background observed cases extensive femoral head following fractures even though original fracture involve femoral head neck observation called massive femoral head purpose evaluate clinical imaging features gain better understanding etiology material methods retrospectively collected cases fractures seen period years evaluated clinical features imaging characteristics findings compared features complications rapidly progressive osteoarthritis post traumatic results fifteen patients ratio mean age years prevalence motor vehicle collision falls common mechanisms injury time interval developing range months initial injury patterns femoral head varied cases cases four cases developed high degree observed near surgical hardware cases one biopsy specimen reveal typical features osteoarthritis necrosis conclusion appears distinct entity necrosis rapidly progressive osteoarthritis suggested variant post traumatic evident subset patients
multi level factors act influence child weight related behaviors study examined simultaneous impact variables obtained level home environment parent modeling child responsiveness outcomes practicing healthy limiting unhealthy child behaviors respectively low income sample cross sectional study caregivers preschool children caregivers interviewed using validated scales structural equation modeling used examine associations outcomes adjusting study region demographics caregivers body mass index found significant associations higher beta confidence interval parental modeling beta less parental restrictive behavior beta parental control beta parental overt control beta less parental permissive behavior beta significantly associated findings suggest synergistic effects control environmental level parental modeling overt control restrictive permissive behavior parent level outcomes factors modifiable support multidisciplinary interventions promote healthy child weight related behaviors elsevier ltd rights reserved
background little detailed evidence available integrated policies impact population health conditions policies realized aim study assess youth alcohol consumption trends province netherlands related development implementation integrated policies methods retrospective multiple case study alcohol policies six stronger declines youth alcohol consumption cases compared four weaker declines controls information policy process period obtained semi structured depth interviews policy information implemented interventions extracted policy documents checked interviews analyzed thematic content results stronger declines alcohol consumption involved sectors public health started implement interventions use regulatory enforcement strategies involvement facilitated framing youth alcohol consumption safety rather health problem whereby local media played substantial role implementation integrated policies facilitated dedicated leadership sufficient resources conclusions reductions youth alcohol consumption stronger started develop integrated policies results suggest integrated policies framing health problem broader societal problem positively influence population health
inhibition function essential therapeutic approach several inhibitors designed anti cancer agents inhibitors aim folding function atpase proteins common human metabolism form nonspecific targets functions dimer coordinating heat shock organizing protein forms bridge complex form coordination conformational changes proteins dimer formation protein protein interactions inhibit substrate protein folding function approach target atpase proteins targets function solely purpose designed compounds block function moreover molecular docking studies competition analysis compounds performed novel compounds determined valuable terminal inhibitors provide promising templates drug design anticancer activities novel compounds tested employing human colon liver cancer cell lines compounds found significant useful treatment human colon liver cancer evidenced vitro silico results
effective sensitive methods molecular detection faecal samples final hosts crucial prevention control human alveolar studies epidemiology parasite little known suitability commercial test kits dna performance standard polymerase chain reaction pcr protocols relation quality dna extracted kits compared four different kits faecal dna research spin kit soil fast dna stool mini kit soil kit extraction dna eggs present negative faecal samples spiked eggs egg concentration tested times dna extraction kits extracted dna sample amplified using three pcr protocols conventional pcr platinum qpcr bio iii qpcr multiplex master mix highest analytical sensitivities molecular detection eggs spiked observed combining either fast dna stool mini kit faecal dna kit qpcr using multiplex master mix sensitivities respectively combinations including remaining test kits soil kit spin kit soil showed markedly lower analytical sensitivity pcr examinations results present study indicate utmost importance select suitable dna extraction kits combination robust pcr methods reagents achieve acceptable analytical sensitivity molecular detection eggs faecal samples elsevier rights reserved
paper analyses discrete hydraulic systems emphasis hydraulic parameter analysis pump turbine power plant developed model make hydro electric power plants transient behavior studies easy accurate especially complicated systems simulation developed based analog mathematical models transient phenomenon equations modeling method governing equations transient flows solved based equivalent electrical circuits defined different system using kirchhoffs voltage law final equivalent circuit system set nonlinear ordinary differential equations generated unsteady friction loss elastic behavior pipe fluid considered pipelines model set nonlinear ordinary differential equations generated using implicit scheme equations nonlinear solved using fourth order method validation carried experimental values also mathematical model pump turbine developed transient behavior two different cases hydraulic systems including pump turbine investigated results correct acceptable method efficient overall simulation hydro power plants including turbine generator transformer
electrochemical used detect specific analytes fluids bacterial chemical contaminants common implementation electrochemical readout usually includes detection recently several researchers developed small low cost single chip silicon based advances heterogeneous integration technology low power implemented paper similar low cost substrates paper deals design low power paper based front end low cost rapid detection environment detection voltage signal provided sensor system small current value generated electrochemical redox reaction system measured order measure low current values noise circuit minimized accomplished pre amplification front end stage typically designed around operational amplifier core appropriate circuit design low power low cost front end identified taking heterogeneous integration various components account operational amplifier core bare custom cmos chip integrated onto paper substrate alongside commercial shelf electronic components general purpose low power two stage cmos amplifier circuit designed simulated process layout design verification submitted multi project manufacturing run simulated results bandwidth mhz common mode rejection ratio power dissipation comparable analytical values
viral load monitoring hepatitis virus hcv necessary diagnose infection monitor response therapy tests involved currently confined specialist institutions need fast accurate assay limited operator input enhance access viral load monitoring evaluated quantification hcv rna serum plasma hcv viral load assay comparison hcv assay serum plasma samples gathered hcv infected individuals four international sites tested hcv viral load assay results compared quantification hcv assay external quality assessment panel eight samples also tested total samples analyzed study qualitative results agreed two platforms samples analysis samples quantified tests showed strong correlation correlation coefficient across range plot data showing mean difference standard deviation log external quality assessment panel hcv viral load assay results quantified log per within standard deviation target value one sample also similarly hcv assay hcv viral load assay performs compared market leading hcv viral load test considered instances rapid near patient testing required
performance wireless industrial process plant affected wireless links reliability recent related works focus mainly wireless links reliability paper focuses links reliability controller wireless highway remote transducer node control application process plant fast sampling link delay short message transmissions node occur concurrently resulting packet collision packet dropout thus leading local cause process plant critical control application unstable therefore paper proposes effective design exponentially weighted moving average filter mitigate effect improve process plants performance order make evident validate existence local experiment carried using device experiment controller delay estimated packet dropout simulation results designed filter show significant improvement process performance terms percentage overshoot compared performance process plant using traditionally optimized pid controller
study proposes third person perception viewed type comparative social judgment domain media influence function assimilation contrast mechanisms process social comparison derived hypotheses tested web based experimental data results showed evidence function assimilation contrast effects also evidence effects effects tended emerge self implication directions future research discussed
paper presents novel method assessing local structural question general non linear state space model method combination application singular value decomposition parametric output sensitivity matrix created simply integrating model symbolic computation reduced model guided results allows confirmation conclusions regarding obtained first step case lack symbolic computation quickly results determination exact structure suitable method discussed detail applied three case studies last two considerably large containing parameters identified respectively elsevier ltd rights reserved
mutation carriers high risk breast ovarian cancer age ranges respectively additionally women mutation associated breast cancer also elevated risk secondary malignancies breast ovarian cancer outcome mutation carriers least good non carriers prophylactic surgeries appropriate use therapies therefore identification mutation important genetic counseling testing screening prevention strategies applied timely manner article reviews impact genetic testing general timing genetic testing diagnosis prior knowledge mutation status carriers newly diagnosed breast cancer additionally risk reducing surgeries including prophylactic contralateral bilateral sensitivity defective breast cancer cell lines differential agents discussed elsevier ltd rights reserved
evolution genes related sex reproduction fish shows high plasticity date sex determination system identified species chromosomes chromosome system sex determination related species show next generation sequencing ngs multi color fluorescence situ hybridization techniques bioinformatics analysis carried objective revealing new information sex determination reproduction end several bacterial artificial chromosome clones contain candidate genes involved processes analyzed compared region related species studies showed localization largest chromosome coincident found chromosome potentially make sex chromosome phylogenetic studies show close proximity species system sex master gene comparative mapping provides evidence preferential association candidate genes particular chromosome pairs using ngs techniques possible obtain integrated genetic map shows chromosome pairs least one clone result important distinguishing chromosome pairs similar shape size analysis shows following chromosomes
carbon emission reduction policies demand building life cycle assessment lca standards however widely believed difficult efficiently reduce carbon emissions buildings revision standards reason korean government developed green building index certification system certification system certification framework based primarily upon carbon emissions building currently assessment program tailored certification system purpose study develop building life cycle carbon emissions assessment program support certification system theoretical consideration certification system building lca standards international green building certification systems analyzed analyses enabled development reflects characteristics certification system current state construction industry consequently appropriate building life cycle carbon emissions assessment program developed support certification system effectively elsevier ltd rights reserved
installation important constructing self anchored suspension bridges installation plan obtained comparative studies concerned information construction steps comparisons generally performed manually using detailed nonlinear finite element method particularly curved cables however procedure complex time consuming thus study proposes efficient method analyze mainly concerned parameters installation plan automatically optimized strategy updating ideal construction steps developed yield plan totally linear coordinate iteration realize coordinate rod model combined coordinate iteration based methods proposed modeling construction steps simulates major deformation system total bridge specific identify equilibrium linear algorithms solve coordinates directly basis avoided design efficiency greatly improved plan effectiveness proposed method demonstrated comparison case studies field test verification application discussion real scale bridge elsevier ltd rights reserved
consider problem cost transmission system among load generator entities known instance classical cooperative game theoretic problem solve problem task dealing combinatorial game utilities hard problem therefore suffers dimensionality marginal pricing pragmatic alternative solve problem since current law voltage law strictly however generic complexity cooperative game theoretic problems just away now manifests difficulty choosing economic bus even dispersed propose application min max fairness policy solve problem give algorithm run polynomial time network cost allocation min max fairness policy minimizes maximum among participating entities step maximum measured terms price application principle leads fair unique equilibrium price vector results large network demonstrate fairness proposed approach
image segmentation important processing many applications image retrieval computer vision one successful models image segmentation level set methods based local context methods though comparatively effective images inhomogeneous intensity considerably computation intensive risk falling local convergence active contour energy function address issues propose region based level set method called based multi scale local binary fitting divergence first apply multi scale theory local binary fitting model build energy term measured divergence regions segmented incorporated energy function utilizes cluster distance adaptive kernel function selection strategy formulate energy function robust initial location contour classical segmentation models deal boundaries noise problems results experiments synthetic real images shown improve effectiveness segmentation ensuring accuracy accelerating minimization energy function
thermal diode fundamental device various mechanisms thermal different temperature dependent thermal conductivity two ends asymmetric interfacial resistance behavior transport asymmetric structures hydrodynamics theory treat heat conduction viewpoint gas flowing media characterized balance equation momentum like navier stokes equation fluid mechanics generalized heat conduction law thereby contains spatial acceleration convection term viscous term viscous term predicts size dependent thermal conductivity appears due convection term also predicts inertia effect like gas passing
memory altered receipt misleading information misinformation effect first studied almost years ago later studies showed suggestive information even lead creation new false memories people whereas previous research focused primarily false information observed events aimed investigate whether memory ones physical performance altered means false manipulated events virtual reality displayed first person viewpoint explored possibility using misinformation effect investigating whether affect feeling competence subsequent sports performance participants took four series soccer field series shown three different types virtual reality performance one accurate representation actual performance two manipulated versions one made performance seem worse negative manipulation one made performance seem better positive manipulation participants rated feeling competence rated accurately displayed real life goal manipulated considered equally accurate representations actual performance non manipulated ones also type manipulation positively correlated feeling competence influence sports performance present study showed memory ones physical performance altered means manipulated virtual reality used elsevier inc rights reserved
relevance wall effectively traditional chinese medicine treating osteoporosis bone fracture now studies pharmacological mechanism mostly centered cell gene level little known metabolic signatures aim study investigate anti osteoporosis effects crude processed global metabolic profiling rats serum liver kidney derived sham model treated groups method total female wistar rats divided five groups sham group model group crude processed treated group treatment rats orally administered beta estradiol crude processed extract therapeutic dose daily throughout experimental period sham group model group orally approximately volume saline solution weeks serum liver kidney samples five groups collected alterations monitored gas chromatography mass spectrometry resulting dataset analyzed principal component analysis pca partial least squares discriminant analysis identification potential biomarkers performed using reference standard library moreover clinical chemistry biomechanical analysis also performed ensure success osteoporosis model validate anti osteoporosis effect crude processed results clear separation trend among sham model treatment group observed pca score plot anti osteoporosis effect processed indicated score plots total metabolite biomarkers identified processed treated groups respectively pathway analysis revealed tyrosine tryptophan biosynthesis leucine biosynthesis methane metabolism glycine serine threonine metabolism metabolism major pathways compared model group levels biomarkers gradually restored normal administration processed conclusion anti osteoporosis effect processed reliably confirmed metabolomics approach osteoporosis prevented processed via amino acid metabolism carbohydrate metabolism energy metabolism vivo rats
paper deals technique simulation higher order electrical circuits parameters varying randomly principle consists utilization theory stochastic differential equations namely vector form ordinary random changes excitation voltage parameters passive circuit elements considered circuit responses analyzed voltage current responses computed represented form sample means accompanied confidence intervals provide reliable estimates method applied analyze responses circuit models optional orders specially consisting cascade connection networks develop model equations state variable method used afterwards corresponding vector formulated stochastic euler numerical method applied verify results deterministic responses also computed help pspice simulator numerical inverse laplace transforms procedure matlab removing random terms circuit model
describe implementations problems interesting solved fast using general purpose processors field programmable gate arrays configurable massively parallel data flow architecture based automatic data flow synchronization designed data task level parallelism briefly introduce prototype device summarize recent architectural changes emphasize practical aspects particular consider problem often overlooked frequently literature algorithm presented fast solves part problem
underlying theories control engineering real time systems engineering assume system mutually neglect central aspects discipline control engineering theory one hand usually assumes free sampling constant input output complex real world timing effects real time engineering theory hand uses abstract performance models neglect functional behavior derives worst case situations little control functionalities physically dominated automotive systems consequence lot potential systematic engineering disciplines increasing design efficiency confidence paper discuss possible approaches engineering current applicability real world problems particular compare simulation based formal verification techniques various construction principles automotive real time control software
software development process developers often seek solutions technical problems encounter searching relevant questions sites developers fail find solutions sites native language chinese translate query search sites another language english however developers non native english speakers often comfortable ask search questions english know proper translation chinese technical words english technical words furthermore process manually cross language queries determining weight query words tedious time consuming process purpose helping chinese developers take advantage rich knowledge base english version stack simplify retrieval process propose automated cross language relevant question retrieval system retrieve relevant english questions stack given chinese question system first extracts essential information chinese english title description input chinese question performs domain specific translation essential chinese information english query highest scored english words retrieving relevant questions repository java questions english stack evaluate performance proposed approach also propose four online retrieval approaches randomly select java questions two chinese websites computer programming query chinese questions approach returns top relevant questions given chinese question users evaluate relevance retrieved english questions experiment results show system outperforms four baseline approaches statistical tests show improvements significant
september attack occurred research psychiatric outcomes focused individual disorders rather broader internalizing int externalizing domains psychopathology leaving unknown whether direct indirect exposure differentially impacted domains rather individual disorders whether effects exacerbated earlier childhood maltreatment stress sensitization unknown participants national sample history psychiatric disorders prior assessed using structured person interview structural equation modeling conducted sample endorsed psychiatric history prior indicated indirect exposure media friends family related alcohol nicotine cannabis dependence antisocial personality disorder int major depression generalized anxiety post traumatic stress disorder ptsd dimensions psychopathology beta int beta whereas direct exposure associated int dimension beta individuals experienced childhood maltreatment risk int dimensions associated exacerbated interactions beta beta respectively findings indicate impacted latent broad domains psychopathology general population rather specific disorders exception ptsd independent effects beyond int indicated significant improvement modification indices findings also indicated childhood maltreatment increases risk associated adult trauma exposure providing evidence concept stress sensitization published elsevier ltd
paper second order sliding mode control approach applied synchronous buck converters proposed controller stabilize synchronous buck converters using simple digital state machine structure without requiring current sensing integral term control loop controller results fast step load start transient responses robust parameter uncertainties fast transients current limitation start accomplished adjusting one controller parameter furthermore hysteresis method introduced control switching frequency proposed approach verified experimental results prototype
life cycle assessment lca prominent technique assessment environmental impacts products typically operates basis average meteorological ecological conditions whole countries large regions limits accuracy lca particularly field agriculture production processes associated agricultural characterized high spatial sensitivity inputs mineral organic accompanying release emissions soil air water nitrate monoxide phosphate emissions largely determined micro spatial environmental parameters precipitation soil properties slope etc therefore highly context dependent spatial variability ignored unit world assumption inherent lca paper present new calculation framework life cycle inventory modeling aims overcome inherent limitation framework allows automated site specific generation assessment unit process datasets demonstrate framework case study cultivation germany results research framework generating data structures first examination significance use cases
previous research demonstrated participants remember significantly survival related information information processed survival relevance recent research also shown survival materials processing result false memories ones adaptive prime solutions insight based problems importantly false memories survival related information facilitate problem solving false memories types information present study explores survival advantage using rather intentional memory task participants rated information either context importance survival processing scenario moving new house following participants solved number compound remote associate tasks half solution primed false memories generated processing task results showed primed false memories task participants solving significantly primed effect greatest participants rated items survival moving processing items survival scenario improved overall problem solving performance even specific problems primed results discussed regard adaptive theories memory
present study investigates relationship violent false memories aggressive behavior sample adolescents two hundred eleven participants completed measures aggressive behavior performed modified version deese roediger mcdermott drm paradigm false memory task lists associated words participants presented list violent words three lists neutral words list free recall task performed violent false memories significantly associated behaviors genders whereas significant correlation aggressive behaviors found males multilevel multiple regression showed prediction behaviors improved entering violent false memories model predictor whereas effect found aggressive behaviors findings indicate significant association violent false memories behavior adolescents foundation professionals services adolescents published elsevier ltd rights reserved
osteoarthritis chronic progressive disease complicated mechanisms involve inflammation cartilage degradation study investigated anti inflammatory action acid human chondrocytes mouse model induced medial vitro chondrocytes pretreated incubated beta production determined method assessed elisa expression inos cox mmp kappa related signaling molecules tested western blotting immunofluorescence staining used detect nuclear translocation vivo mouse model received intraperitoneal injection either saline every day hematoxylin eosin fast green staining utilized evaluate severity cartilage lesions weeks following surgery inhibited production elevated expression inos cox mmp reversed beta induced chondrocytes addition beta significantly induced phosphorylation kappa signaling phosphorylation response blocked immunofluorescence staining demonstrated suppress beta induced nuclear translocation vivo cartilage treated mice exhibited less cartilage degradation lower scores taken together possesses great potential value therapeutic agent treatment published elsevier
heterogeneous suitable add process conventional wastewater treatment methods aiming full degradation emerging contaminants contributing water pollution work examines photo degradation two frequently detected emerging contaminants caffeine acid using titanium dioxide films commercial films comparison films prepared electrochemical titanium metal reached lengths high growth rate present open porous structure large specific surface area suitable efficient adsorption contaminants formation large number photocatalytic active sites degrees films obtain crystal structure absorb range present significant photocatalytic activity high degradation rates examined emerging pollutants furthermore present small variability photocatalytic efficiency big range solutions values consecutive photocatalytic cycles rendering suitable various wastewater treatment conditions elsevier rights reserved
prophylaxis standard allogeneic stem cell transplantation sometimes low dose inhaled monthly human metabolism depends cytochrome frequency mutant forms decreased function asians certain together common use inhibitors process creates risk impaired clearance resulting toxicity expected high doses given active infection examined charts consecutive patients center assessed hospital charges management toxicities unexplained time likely attributable twenty eight percent experienced significant toxicities added charges least thirteen percent suffered major toxicity added charges least median added charge shorter survival recipients including died toxicities one proven postmortem non functional homozygous mutation charges care attributable toxicity exceeded genotyping cost fold findings encourage routine use genotyping patients considered
point vortex models frequently encountered conceptual studies fluid dynamics also practical applications instance spherical geometry motion vortex centres governed dynamical system known poisson structure construct poisson integration methods dynamics splitting constituent vortex pair terms backward error analysis method formally known provide solutions modified poisson system correct modified function different pair wise interactions considered also used construction higher order methods energy momentum conservation splitting schemes demonstrated several test cases particular pairwise interactions schemes allow scalable parallelization results linear opposed quadratic scaling computation time system size scaling number processors accordingly elsevier rights reserved
solar tower technology promising way generate sustainable electricity concentrated solar radiation one effective variants technology called volumetric air receiver used convert concentrated radiation heat component consists high temperature resistant cellular material radiation transfers heat air flow fed ambient air called volumetric radiation volume receiver open permeable cells material way larger amount heat transfer surface supports solid gaseous heat transfer comparison tubular closed receiver finally heated air directed steam generator conventional steam turbine system study advanced cellular metal structure designed manufactured tested use open volumetric receiver consists pairs flat metal technology based one primarily developed treatment combustion engine exhaust gases number variations pure linear structure introduced increase local turbulence radial flow firstly set samples tested laboratory scale experiments determine effective properties solar thermal efficiency results compared theoretical predictions finally three promising materials used test research platform solar tower air outlet temperatures degrees achieved efficiencies state art technology currently used main receiver solar tower next lifetime models developed increase overall reliability technology elsevier ltd rights reserved
emergence big data use nosql sql technology rising rapidly among internet companies enterprises benefits include simplicity design horizontal scaling control availability nosql databases increasingly considered viable alternative relational databases organizations recognize schema less data model better method handling large volumes structured semi structured unstructured data captured processed today example nosql databases often used collect store social media data paper aims introduce concepts behind nosql provides review relevant literature highlights different nosql database types provide arguments adopting nosql small prototype application developed assess stated nosql benefits illustrate differences sql nosql approaches last section paper offers conclusions recommendations research expand upon research work
rainwater harvesting inexpensive water source indoor use also sustainable water management practice since contribute reduction runoff volume peaks control non point source pollution aim paper provide method sizing rainwater harvesting tanks based local daily rainfall record served family size roof collection area roof type house water uses factors various methods used worldwide presented compared comparative application methods made using daily rainfall record meteorological station near village northeast greece based proposed method optimum tank size computed allowing excess water setting zero use public water supply method result reduced tank sizes compared methods tested
resistance important trait related ecology survival plant species vessel network characteristics vessel length connectivity affect spread gas filled vessels functional ones triggering hypothesized resistance vessels randomly distributed throughout vessel network predicted single vessel air injection vulnerability curves thus affected sample length longer stem samples predicted appear resistant shorter samples due sampled path including greater numbers vessels evaluated vessel network characteristics english black gray constructed long segments also constructed standard method used computer modelling estimate curve shift expected pathways composed different numbers vessels three species segments rose exponentially vulnerable segments curve shapes exponential consistent modelling data supported observed shifts related path length vessel network characteristics results suggest exponential represent realistic curve shape individual vessel resistance distributions species network level presence vessels higher resistance help avoid spread tissue dehydration
data mining intrusion detection one cutting edge researches focus network security database information decision making due emergence new forms attacks intrusion network need new intrusion detection system able detect new unknown attacks nevertheless complexity diversity network security alarm data difficult analyze evaluate network security situation accurately intrusion detection protect network system attacks security used machine learning technology intrusion detection system order improve system performance effectively paper studying characteristics network data intrusion put forward intrusion detection system based rough set theory detect anomaly action network method extract detection rule model network connection data dealing incomplete data discrete data exit data mining effectively basic ideas techniques data mining based intrusion detection architecture real time data mining based ids discussed meanwhile mainly analyzed basic structure intrusion detection system application several machine learning methods intrusion detection include bayesian classification based method neural networks based method support vector machine based method svm experiments results show models methods generation framework proposed paper effectively detect network intrusion
studies evaluated whether retina involved migraine evaluation retinal nerve fiber layer examined ocular coherence tomography oct conflicting results aim case control study evaluate retina migraine patients migraine aura without aura chronic migraine evaluated age sex matched normal subjects selected healthy controls patients examined oct ganglion cell layer thickness thickness total volume calculated right eyes left eyes seventy seven patients women enrolled study patients compared significant reduction thinner patients compared moreover showed reduction compared finally found significant inverse correlation thickness total number headache attacks per months data suggest involvement retina especially group although migraine episodic recurrent disease chronic nature cause permanent structural abnormalities involving brain also retina
objective objective identify predictors adherence hormonal contraceptives female population study design retrospective cohort study female veterans san healthcare system study period april march patient followed year index date defined date first contraceptive prescription study time period adherence defined medication ratio income estimated using code based median household income split lowest group logistic regression used analyze association adherence independent variables results total patients included final analysis majority population white receiving month supply medication following independent variables predictive increased adherence month supply versus month supply odds ratio confidence interval age group versus income versus reference group following associated decreased adherence new start versus continuing user provider versus primary care provider highest weight group versus lowest weight group conclusion hormonal contraceptive adherence population optimal providing month supplies high value therapies hormonal contraceptives one strategy improve adherence initiatives target lower socioeconomic status new start populations increase contraceptive adherence also considered implications adherence hormonal contraceptives studied literature high value therapies identifying predictive variables adherence implications establishing possible interventions refining benefit structures order increase adherence published elsevier inc
double cable system wide application prospects suspension bridges longitudinal restraint stiffness double cable system tower studied paper two formulas derived calculate longitudinal restraint stiffness double cable system tower load distribution cables respectively mathematical model two span double cable suspension bridge created verify formulas tower top displacement cable force obtained formulas results good agreement results calculated fem effects important design parameters longitudinal restraint studied analysis shows restraint stiffness increases increasing unit weight bridge dead load distribution top cable ratio bottom cable elastic stiffness cables effects tower top displacement span length also analyzed suggestions given design double cable suspension bridge
introduction osteoarthritis one common causes musculoskeletal systems prevention disease comprehensive treatment proper health related behavior becomes extremely important factor maintaining optimal health condition aim study assess relationship reported pain disability level health related behaviors undertaken patients acceptance disease materials methods study group consisted patients diagnosed according criteria method used study employed pain vas health assessment questionnaire disability index acceptance illness scale health behavior inventory results average age among respondents years age duration disease years pain experienced movement rest correlated positively physical disability studies indicated positive linear correlation age physical disability acceptance disease depends mostly age pain motion rest disability levels analysis health related behaviors indicates average severity behavior statistically significant physical disability conclusions acceptance illness significantly reduced age progressive levels disability severity pain progressive levels disability younger age respondents motivate engage health beneficial behavior
age related changes brain structure question interest broad field research structural decline consistently linked functional consequences including cognitive impairment dementia one areas considered crucial importance throughout process medial temporal lobe primarily hippocampal region gender also considerable effect volume deterioration subcortical grey matter structures hippocampus influence interaction disproportionate volume changes mediated hormonal effects brain hippocampal volume loss appears become accelerated postmenopausal period decline significant influences region hippocampus highly vulnerable pathological influences additionally menopause associated critical changes involved neurodegeneration micro alterations consequent functional deterioration critical hippocampal regions result clinical cognitive impairment especially already decline cognitive reserve capacity several lines potential vulnerability factors appear interact menopausal period eventually leading cognitive decline mild cognitive impairment alzheimers disease focused review aims delineate influence risk factors neurodegenerative processes age gender critical subcortical structures light brain derived estrogen effects menopausal period appears key importance risk cognitive decline representing time special vulnerability molecular structural functional influences offering narrow window potential protective effects
rats sign prone attribute incentive salience reward cues manifest propensity approach contact cues addiction like behavior also exhibit poor attentional performance relative goal associated attenuated acetylcholine levels prefrontal cortex demonstrate cellular mechanism linked synthesis accounts attenuated cholinergic capacity first found electrical stimulation basal increased cortical transporter mediated transport redistribution synaptic plasma membrane neither increases uptake translocation occurred second consistent uptake translocation alterations demonstrated reduced ability support cortical release vivo compared reverse dialysis extracellular potassium levels third rats significantly likely develop sign tracking behavior treated systemically conditioned approach training inhibitor consistent proposed mechanisms administration attenuated potassium evoked levels prefrontal cortex measured vivo propose loss dependent activation cortical cholinergic activity top executive control behavior producing bias bottom stimulus driven attention attentional bias contributes reward processing thus identifies novel mechanism support psychopathology including addiction
background due leaves var become popular plant study report fine mapping analysis candidate leaf gene using population population derived two parental lines white leaves leaves results genetic analysis indicated leaf trait controlled single dominant gene named using markers developed based reference genome gene mapped interval chromosome flanking markers genetic distances respectively recombination rate within interval almost times higher usual level caused assembly error reference genome interval primers designed based another reference genome among newly designed markers found closest flanking gene genetic distances respectively interval two markers reference genome seven annotated genes located within genomic region shows high homology reductase identified candidate gene blast analysis revealed interval located scaffold confirming existence assembly error interval reference genome conclusions study identified candidate gene foundation cloning functional analysis gene
due crucial highly task utmost importance understand leading effectiveness multidisciplinary emergency management command control teams argue formal team leader needs initiate structure team meetings support organizing work facilitate team learning especially team learning process constructive conflict sample teams performing realistic exercise including one two team meetings sum coded team leaders verbal structuring behaviors events rated constructive conflict external experts rated team effectiveness field experts results show leaders effective teams use structuring behaviors often except asking procedural questions time support constructive conflict making conclude command decision decreasing frequency time
complementary terrestrial mobile communication systems mobile satellite communication system fill gaps covered terrestrial network provides solution emergency communication disaster road future satellite terrestrial integrated communication networks invited proposals candidate radio interface technology satellite component international mobile advanced china proposed long term evolution satellite candidate considered advanced satellite technology submitted satellite candidate specified based terrestrial advanced standards developed considering satellite requirements number modifications advanced made adapt satellite radio transmission environments paper provides general introduction new characteristics satellite
study aimed verify prevalence characteristics sports injuries determine association physical activity level perception health related quality life hrqol brazilian master athletes cross sectional study conducted male master athletes age mean hrqol assessed using medical outcomes study short form evaluated using international physical activity questionnaire information regarding collected using reported morbidity survey poisson regression estimated prevalence ratio used measure association hrqol majority athletes showed high prevalence reported one injury occurred training primarily affected lower limb adjusted regression models showed positive association functional capacity confidence interval physical component hrqol furthermore negatively associated hrqol functional capacity physical aspects pain social functioning emotional aspects mental health domains physical component mental component results highlighted master athletes showed high prevalence primarily lower limbs positively correlates physical hrqol domain whereas decrease hrqol levels physical mental domains
paper deals generalization network decomposition related structural properties relatively large class finite dimensional strictly causal systems described state space representation form resulting energy metric function defined systems induced output signal dissipation power demonstrated power oriented approach determines structure system representation corresponding system state space topology special form physically correct internal structure equivalent state space representation derived natural consequence strict causality state space energy conservation assumption state requirement
one important challenges creation intelligent environments specifications intelligent behaviours system exhibit processing situations computationally demanding report advances specification rule based language allows natural expression situations interest occur intelligent environments language focuses quasi real time situations includes new temporal operators allow natural reference time intervals explained system implemented system validated within smart office scenario
evolution temperatures internal combustion engines cold start quite important greatly affects fuel consumption vehicle emissions paper advanced thermal management model presented used automotive diesel engine order determine evolution different temperatures warm stage paper focuses complete description engine components coolant circuit circuit objective calculate heat exchanges thermal masses sub models cylinder head engine block oil fluids experiments engine realized order calibrate model heat release friction losses also obtain temperature transient stage last results used order validate model approach gives possibility determine coolant oil temperature evolution minimum nodes relatively short calculation time evolution coolant temperature vehicle cycle cold start studied good agreement obtained finally model used order study possibilities reduce vehicle mass reduction engine mass elsevier ltd rights reserved
since conventional adequately simulate disaster situations participants feel sense tension developed game based system focuses situational audio visual scenario based improve visual reality adopt simple augmented reality head mounted display simple represents extensive disaster situations rain smoke fire overall disaster situations dynamic three dimensional computer graphics onto real time vision captured stereo camera attached
background people diabetes comorbid severe mental illness form growing population risk increased mortality morbidity compared diabetes alone increasing interest interventions target diabetes order help improve physical health reduce associated health inequalities however lack consensus outcomes important comorbid population trials differing focus physical mental health core outcome set includes outcomes across conditions relevant patients key stakeholders needed methods study protocol describes methods develop core outcome set use effectiveness trials self management interventions adults comorbid type diabetes use modified delphi method identify rank agree core outcomes comprise two round online survey workshops involving patients health social care professionals health care experts academic researchers third sector organisations also select appropriate measurement tools outcome proposed core set identify gaps measures exist discussion proposed core outcome set provide clear guidance outcomes measured minimum trials interventions people coexisting type diabetes improve future synthesis trial evidence area also explore challenges using online delphi methods hard reach population examine differences opinion outcomes matter diverse stakeholder groups
paper focuses design control active suspension system tubular linear motor integrated spring damper system vehicle spring takes weight vehicle therefore electric linear motor designed compact provide forces adjust damping characteristic design construction active suspension system control strategy validation measurements test bench presented
role produced mediating varied physiological effects mammals enormous recent interest understanding biology exploiting pharmacological potential early days field signaling large gaps exist understanding biological targets mechanisms action regulation biogenesis clearance two branches within sulfur metabolic pathway contribute production reverse pathway two phosphate dependent enzymes beta synthase gamma convert successively cysteine branch cysteine pathway converts cysteine via dependent cysteine aminotransferase subsequently sulfur transferase bound review present overview kinetics generating reactions compare structures enzymes involved biogenesis discuss strategies regulation article part special issue entitled enzymology elsevier rights reserved
assessed propensity false memories among patients obstructive sleep syndrome twenty one patients controls matched sex age education recruited encoding adaptation deese roediger mcdermott paradigm used induce false memories retrieval participants completed forced choice recognition task distinguish memories based traces based traces task encouraged retrieval based either traces groups performed similarly however task required retrieval based solely traces patients exhibited poor discrimination produced false memories finding leads increased propensity produce false memories discussed within framework fuzzy trace theory activation monitoring theory
study explored aged care support workers perceptions health influenced job highlighting similarities differences working community based institution based care support workers working two institution based three community based aged care organisations invited participate semi structured interviews undertaken ten participants open ended questions participants perceptions health related work data analysed general inductive approach four central themes identified many related mental opposed physical health love job described various sources satisfaction participants factors commonly negative aspects stress negative influences aspects health support described positive influences health supported participants job described physical nature job positive negative impact participants health support workers perform numerous tasks often impact upon health aspects job impact health worker improved communication support management recognition support workers contribution society targeted enhance support worker health additional training reduced time pressure also represent aspects improvement optimise support workers physical health
argue health care justify just military provide reasons explain offering services find two versions view literature giving different standards justification show views either permissive result problematic based restrictive produce problematic develop middle ground position believe better combines respect healthcare professionals concern patients claim short justify according standard rather according standards others developed
independent component analysis one basic tools data analysis aims find coordinate system components data independent existing methods based minimization function fourth order moment third order moment received much less attention paper present competitive approach based split gaussian distribution adapted asymmetric data consequently obtain method works better classical approaches especially case underlying density symmetric typical situation color distribution images elsevier ltd rights reserved
introduction depressive symptoms common patients assessed symptoms effect cognitive functioning discrepancies patient informant reported depressive symptoms found diagnostic groups raising concerns value assessing depressive symptoms via self report alone study aimed examine relationship discrepancies cognitive functioning heterogeneous outpatient neuropsychological sample method sixty two patients variety diagnoses stroke mild cognitive impairment completed measure depressive symptoms battery neuropsychological tests informants also rated patients depressive symptoms completed measure patients functional abilities results patient informant reports depressive symptoms moderately correlated larger differences patient informant reported symptoms associated poorer verbal learning memory greater functional impairments conclusions moderate level agreement found depressive symptoms consistent past studies using specific neuropsychological patient groups studies clinical non clinical populations results highlight utility collecting informant reports depressive symptoms neuropsychological evaluations
background given risk opioid misuse among chronic pain patients treated opioid pharmacotherapy non pharmacological treatments needed light deficits population therapies enhance positive affect useful purpose study examine effects mindfulness oriented recovery enhancement intervention ecological assessments pain positive affective experience determine changes pain affect interaction associated opioid misuse post treatment methods study examined data subset participants previously published rct versus support group control across weeks treatment patients completed measures pain affect multilevel models generalized estimating equations examined effects treatment pain positive affect generalized linear models examined associations pain affect changes opioid misuse post treatment results patients reported significantly greater improvements pain positive affect patients entire course treatment patients significantly likely exhibit positive affect regulation patients finally improvements positive affect pain course intervention associated reduced risk opioids post treatment conclusion useful non pharmacological treatment pain deficits among chronic pain patients risk opioid misuse authors published elsevier ireland ltd
note addresses problem optimal filtering class continuous time time varying stochastic systems time variation character considered periodic state space representation optimal filter designed based unique periodic solution suitable lyapunov differential equation periodic stabilizing solution suitable generalized periodic differential equation numerical experiments also added show effectiveness proposed method elsevier rights reserved
near highway road gradient approximately built side year soft spots also commonly named observed starting late april lasting entire summer resulted extremely unsafe driving condition frequent accident occurrences conventional repair methods effectively solve issue newly developed geotextile high specific surface area installed selected test section mitigate issue august type geotextile provide high relatively high capillary force consequently able transport water high directional unsaturated conditions test results initial proved effectiveness geotextile alleviate subsequent issue however still concerns regarding long term performance microscopic drainage channels mechanical failures data collected past years used analyze evaluate effectiveness fabric scanning electron microscope used explore interaction fabric situ soils determine condition fabric years installation american society civil engineers
study propose adaptive hybrid artificial colony algorithm train unlike standard abc algorithm two new parameters utilized solution search equation arithmetic crossover rate coefficient algorithm gains rapid convergence feature usage arithmetic crossover applied two different problem groups performance measured firstly performed numerical benchmark functions results show algorithm efficient standard abc algorithm secondly trained using algorithm identify nonlinear dynamic systems application begins randomly selected initial population average rmse obtained four examples considered training train error values respectively computed also test error values examples respectively found although varies according examples performance increase occurs additionally seen algorithm abc algorithm examples obtained results compared neuro fuzzy based approaches commonly used literature seen proposed abc variant efficiently used training elsevier rights reserved
objectives present study aimed investigate relationship airflow limitation severity comorbidities comprehensive health examination methods cross sectional study included men women aged underwent lung function test medical defined forced volume forced vital capacity logistic regression analysis used assess association severity presence comorbidities results compared normal lung function group subjects higher prevalence lung cancer odd ratio confidence interval men hypertension women diabetes hyperglycemia men women men women adjusting potential confounders men lung cancer mets joint statement significantly associated moderate severe adjustment women hypertension diabetes hyperglycemia mets mets japanese committee criteria mets significantly associated mild adjustment hypertension significantly associated moderate severe adjustment women conclusions significant relationships found severity presence comorbid lung cancer men hypertension women diabetes hyperglycemia mets men women knowledge comorbidities associated widely raise awareness chronic obstructive pulmonary disease copd
indoor smart grids proper operation building environmental systems essential energy efficiency automatic detection classification abnormal conditions important application computational intelligence tools buildings environmental systems include building automation system heating air conditioning loads used develop automatic building diagnostic tools health monitoring fault detection diagnostics novel health monitoring system variable air volume unit developed using fuzzy logic detect abnormal operating conditions generate fault signatures various fault types artificial neural network classification technique applied fault signatures classify fault type tested simulated data actual data system created demonstrated recognize faults accurately classify various fault signatures test faults interest
study examined association psychiatric symptoms diabetes knowledge among adults serious mental illness type diabetes relationship glucose control also examined hierarchical linear regression greater negative symptom severity lower cognitive functioning predicted lower though cognitive functioning negative symptom severity analyzed simultaneously pearson correlation showed significant relationship although symptom severity cognitive functioning related among population cognitive functioning particularly important published elsevier inc
paper describes development implantable drug delivery systems early stage current stage gives detailed summary non biodegradable systems applications different areas vascular disease treatment birth control cancer treatment eye disease treatment also describes development various implantable pump systems atypical challenges future elsevier rights reserved
currently deemed promising plasma facing material future power plant case accident air get contact air temperature rise degrees due nuclear decay heat case damaged coolant supply heated neutron activated forms volatile radioactive oxide atmosphere new self smart alloys adjust properties environment plasma operation preferential elements leave almost pure surface facing plasma accident elements bulk forming oxides thus protecting mobilization good plasma performance suppression oxidation required smart alloys bulk titanium alloys exposed together pure samples steady state plasma identical conditions linear plasma device psi temperature samples similar degrees degrees energy ions matching conditions expected first wall weight loss measurements demonstrated similar mass decrease smart alloys pure samples oxidation exposed samples proven effect plasma exposure oxidation resistance alloy demonstrated advantageous fold lower mass gain due oxidation pure new containing thin film systems demonstrating superior performance comparison systems pure oxidation rate constant thin film times less pure however detected reactivity bulk smart alloy humid atmosphere calling improvement
conventional flight control design systems usually considered separately resulting complex system inefficient integration functions therefore concept aircraft energy control brought solve problem coordinated control using goal study develop optimal energy control system based concept optimal energy fixed wing unmanned aerial vehicles energy aircraft characterized two parameters specific energy distribution rate driven total specific energy rate driven study system identification method employed obtain energy model small uav proposed approach consists energy distribution loop total energy loop energy distribution loop designed based linear quadratic gaussian regulator responsible regulating specific energy distribution rate zero hand total energy loop based simple gain scheduling method responsible driving error total specific energy rate zero implementation successfully validated hard loop simulation applied uav
membrane based using dielectric developed explored present study dielectric soft smart material used fabricate actuator characteristic lightweight high elastic energy density large deformation external direct current alternating current voltages typical acoustic performances membrane based experimentally identified using transmission loss duct acoustic measurement system found resonance peaks membrane based controlled applying different external voltages maximum resonance frequency shift resonance peaks achieved indicated membrane based adjusted absorb target noise without addition mechanical part furthermore resonance shift multiple mechanisms using proposed discussed aiming achieve multi peaks noise reduction present results also provide insight appropriateness absorber possible use acoustic treatment replace traditional acoustic treatment noise reduction technology elsevier ltd rights reserved
purpose purpose paper evaluate online moment intervention promote healthy eating overweight food intolerance symptoms design methodology approach study involves factorial design two conditions group weight loss food intolerance condition intervention control intervention aimed generate moment providing knowledge regarding relationship food problem overweight food intolerance negative aspects problem creating behavioural model encouraging hope participants receiving intervention completed measures dietary behaviour either weight food intolerance symptoms receiving intervention one month later control participants provided measures receive intervention findings significant reductions weight food intolerance symptoms however compared control participants participants intervention conditions reported greater intentions eat improved healthy eating behaviour time following intention treat explanatory analysis practical implications encouraging individuals perceive everyday situation time change adopt healthier behaviour early prevent future diet related medical events benefits individual health care costs originality value quick easy online moment intervention improves dietary behaviour minimally adapted suit individuals differing health needs
activation inhibitor represents essential mechanism angioedema patient protection function plasma usually measured based residual activity protease involved pathological process proposed alternative enzymatic measurement function based contact phase activation correlation angioedema diagnostic requirements methodsthe contact phase using purified components standard plasma sample kinetics activity monitored using pro independently prevented interference possible high plasma activity samples protease inhibitor receiver operating characteristics roc used calculate assays diagnostic performance resultsthe calibration curve built using standard threshold limit function quantified sample reference interval established based healthy individuals men median women median median values female donors lower others due estrogen yet function remained within reference interval roc curve calculation provided following optimum diagnostic cutoff values women area curve auc sensitivity specificity men auc sensitivity specificity conclusionthe performance outcome provided features suitable angioedema diagnostic follow established means formation process assay preferred method based protease target
objective present case distal rare injury among ubiquitous lateral ligament sprains ankle clinical features old recreational player treated ankle demonstrating increased translation test pain inversion stress also pain external rotation rays demonstrated fractures intervention outcome conventional protocol protect rest ice price employed common lateral ankle sprains followed early mobilization training tilt board recovery prolonged ossification ankle seen follow radiographs conclusion management implications outcome sequelae uncommon severe commonly seen lateral ankle simple physical examination procedures useful identifying sprains routine examination injured ankle emphasized include external rotation stress test
vertebrates many responses stress homeostatic maintenance basal metabolism regulated plasma glucocorticoid hormones despite crucial functions levels typically variable among individuals examined contribution several physiological factors individual variation plasma number hormone neurons area brain free living mountain addressed three hypotheses current condition hypothesis facilitation hypothesis trade hypothesis differential white blood cell count identified strong contributor individual variation baseline stress induced number neurons contrast found relationship body condition energy stores reproductive investment providing support current condition hypothesis tradeoff hypothesis involving reproduction difficulties interpreting functional consequences variation differential white blood cell counts unable distinguish facilitation hypothesis trade hypothesis related immune function however strong association differential white blood cell count hypothalamic pituitary adrenal hpa activation suggests thorough examination immune profiles critical understanding variation hpa activation
paper presents new approach based combination particle swarm optimization gradient method solve unit commitment problem proposed strategy optimizes combination production units operations determines appropriate operational scheduling production units satisfy expected consumption specific duration production unit conducted constraints render problem complex combinatorial nonlinear resolution problem conducted several constraints take account minimum minimum time constraints start cost reserve adopted approach applied ieee electrical network containing production units simulation results clearly proven gradient pso method competent optimizing problem comparison existing methods
known disorders pathways lead neurological hematological immunological diseases renal impairments association malignancies nucleotide homeostasis depends three stages metabolism novo synthesis catabolism recycling metabolites addition used substrates nucleotide also act precursors used biosynthetic pathway brains via cycle synthesis brain membrane utilize addition glucose three compounds present blood stream polyunsaturated fatty acids like acid authors using rat models found oral administration two phospholipid precursors omega fatty acids along diet increase amount synaptic membrane generated striatal neurons rats induced parkinsons disease authors found hypertensive rat fed cognitive deficit resulted improved also recently considered molecule involvement important neurological functions improving memory sleep disorders anti effects neuronal plasticity brain via specific receptors successively corresponding nucleotides present review devoted enzymology pathways whose importance attracted attention several researchers investigating mechanisms underlying brain
desire achieve optimal temperature control building energetic performance description one steps followed identify experimentally dynamic model heat transfer building models used heat equations time domain systems multiple inputs outputs equations represented matrix form manner easily obtain state space representation subsequently transfer function representation furthermore model parameters determined easily used example detailed study normal size house number inside outside parameters monitored
western nations slowly emerge recent global demand among citizens authorities practice seen practice ethical leadership although conditions favourable research ethical leadership extant research perspectives ethical leadership largely silent meaning practice ethical leadership context big ethical questions consequence research ethical leadership although meaning offers little guidance implement sustainable ethical solutions systemic problems research note outline proposal ethical leadership leadership greater good identify three avenues research leadership greater good existing critical perspectives ethical leadership elsevier ltd rights reserved
purpose review aortic valve disease relatively common encompasses congenital acquired forms aortic valve common type cardiac development aortic valve disease since description link approximately decade ago significant advances genetic molecular understanding diseases recent findings recent work defined congenital cardiac phenotypes linked mutations addition novel genes discovered using new genetic technologies humans furthermore several mouse models described defining role endothelial aortic valve morphogenesis whereas others implicated new genes murine models along cell based studies led molecular insights pathogenesis summary findings provide important insights molecular genetic basis aortic valve malformations including specifically highlighting role endothelial cells addition numerous investigations mechanisms demonstrate importance developmental origins signaling pathways communication valve endothelial cells underlying interstitial cells valve disease onset progression
two studies examine preferences long term partner traditional non traditional gender roles studies demonstrate link preference traditional partner however study also demonstrates strong preference among women non traditional partner measured ambivalent introducing participants either traditional non traditional character opposite sex study women high toward men reported preference traditional man compared women low toward men found link hostility toward men study showed men high preferred traditional woman men low case hostile studies provide evidence using toward men inventory ambivalent inventory demonstrate relationship ideology partner choice adds literature partner preference date focused preference dimensions attractiveness resources authors published elsevier ltd open access article license http creativecommonsorg licenses
endoplasmic reticulum involved final processing peptide precursors generate mhc class restricted epitopes thus influences cytotoxic immune responses controlling peptide repertoire available cell surface presentation mhc molecules enable critical role antigen processing peptides unique molecular mechanism turns hydrolysis activity peptide length sequence dependent manner thus unlike recognize peptides order read substrates length exemplify validate molecular mechanism carried studies molecular recognition antigenic peptides terminus report determined resolution crystal structure complex regulatory domain natural epitopes terminus displayed fusion protein reveals structural details peptides recognition uses specificity regulatory domain bind peptides end side chain terminal residue time flexibility length sequence middle peptides minimal interactions elsevier ltd rights reserved
shift focus genes cells systems approach cell biology also providing clinical medicine shift holistic approach efficient disease management inevitably brings focus one longest healthcare systems world namely medical system indigenous indian distinctive feature systems approach health disease theoretical framework offers new paradigm understanding human system networked functional entity wherein system properties integral components open dialogue cell centric systems biology organism centric open new exciting research beneficial sciences leave major clinical practice
discharges widely distributed small point sources pollutants septic tanks contribute microbial nutrient loading streams pose risks human health stream ecology periods ecological sensitivity present first comprehensive data variability septic tank effluents potential source water pollution different seasons associated links influence stream waters determine parameters nutrient variations biological physicochemical properties effluents sampled septic tank systems investigated concurrent analyses upstream downstream receiving waters study revealed months spring summer effluents similar composition months autumn winter however spring summer effluents differed significantly autumn winter concentrations biological oxygen demand arsenic cobalt titanium zinc exception greater summer spring concentrations parameters greater winter receiving stream waters also showed significant seasonal variation dissolved organic carbon lithium escherichia coli abundance clear significant influence downstream waters relative upstream source total suspended solids total particulate ammonium coli findings study found seasonal variation place effluent discharges factor affecting adjacent stream quality call appropriate measures reduce discharges away water courses elsevier rights reserved
background emotional dysregulation impaired attachment potential contributors development psychopathology adolescence raises question whether oxytocin attachment hormone beneficial contexts recent evidence suggests intranasal administration increases behavior including trust empathy also facilitate social attenuating stress response interpersonal conflict date studies investigated effects intranasal oxytocin neurophysiological emotion regulation strategies healthy adolescents particularly parent adolescent interaction understand mechanisms study examine effects emotion regulation adolescents parent adolescent stressful interactions adolescents visual neurophysiological strategies visualizing attachment related pictures hypothesize influence outcomes conditions stress predict increase feelings safety attenuate stress hostile behavior conflict situations also enhance attachment security increasing comfort proximity seeking reducing neurophysiological objective objective study evaluate effects insecure adolescents studying behavior discourse one parents neurophysiological responses pictures eliciting attachment related emotions visual exploration strategies also investigated methods randomized double blind placebo controlled parallel group design healthy male adolescents classified attached receive international units versus placebo minutes experimental tasks adolescent invited engage experimental conflict discussion one parents conflict session coded verbal non verbal interaction behavior using goal corrected partnership adolescence coding system adolescent asked visualize attachment related pictures screen eye tracking neurophysiological responses including activity heart rate recorded simultaneously continuously attachment related picture viewing affective picture set adolescents results enrollment study completed data analysis july study results submitted publication winter conclusions complex molecule many facets yet fully understood experimental protocol increase scientific clinical knowledge emotion regulation skills insecure adolescents assessing impact parent adolescent interaction visual processing attachment related emotions positive results lead therapeutic uses treat emotion dysregulation adolescence
objectives assess completeness history taking physical examination notes junior doctors university hospital per approach learned medical school methods retrospective study reviewed admission notes written junior doctors residents academic tertiary care medical centre saudi arabia two month period notes evaluated completeness using checklist developed reference relevant medical checklist included items related history taking physical examination based review notes checklist items evaluated complete incomplete present applicable according set criteria data analysed information frequency relative frequency types results history items varied completeness high end asking chief complaint duration associated symptoms factors conducting systemic review marked complete notes respectively low end asking previous episodes allergies medications family history complete notes respectively physical examination items poorly documented especially breast examination present notes conclusions junior doctors history notes often incomplete follow approach taught medical school reasons studied via focus group discussions junior doctors
enzymes effective catalysts evolved perform defined highly specific chemical transformations studying nature rate enhancements mechanistic strategies enzymes important basic scientific point view order improve rational design kinetic isotope effect important tool study chemical reactions used extensively field enzymology theoretically prediction phase environments enzymes challenging due need include nuclear quantum effects herein describe recent progress group development multiscale simulation methods calculation accurate computation also describe application several enzyme systems particular describe use combined quantum mechanics molecular mechanics methods classical quantum simulations development various novel path integral methods reviewed methods tailor suited enzyme systems degrees freedom involved chemistry need application hybrid quantum classical simulation approach three case studies presented first case involves proton transfer alanine second case presented involves multidimensional free energy simulations together kinetic isotope effects combined study reaction mechanism finally discuss proton transfer oxidase enzyme employs tunneling catalytic fine tuning tool elsevier inc rights reserved
defined care provided individuals parents universal behavior among humans shaped evolutionary history remains important contemporary society dysfunctions serious sometimes fatal consequences vulnerable infants children spite importance still much learn regarding underlying neurobiological systems governing expression review lack behavior among traditional laboratory species led blind spot understanding critical facet human social behavior relevant neurobiology based known draw model systems ranging primates describe conserved set neuroendocrine mechanisms supporting expression care review describe neurobiological behavioral consequences care lastly identified several outstanding topics area care deserve research efforts better advance human health wellbeing wiley periodicals inc develop
choice particular material certain product perform certain function task often either choice looks obvious habits convergent thinking lead engineering designer persist usual material application done early stages product development choice materials involves complex decision making processes balancing intricate functional technological economic criteria reflecting function part product manufacturing process production volumes final cost development teams rely basic methods decide materials using engineering properties benchmarks methods seldom address whole problem material function shape process cost environmental impacts paper starts overview existing methods selecting materials moves onto propose new selection procedure materials selection engine overcomes limitations found former methods uses materials engineering properties accommodate technical fitness also considers life cycle cost items environmental impacts create decision space best materials application mapped classified according importance design team give economics environment issues upstream downstream life phases informed decisions made case study presented aiming better understanding procedure proposed elsevier ltd rights reserved
testosterone recent years proven essential normal growth maturation small growing concomitantly low functional ovarian reserve characterized small growing follicle pool associated low testosterone levels ovarian adrenal origin study therefore investigated whether peripheral sex steroid precursors testosterone levels potentially reflect adrenal function retrospective cohort study consecutive women presented affiliated fertility center new york city investigated series statistical models whether low peripheral sex steroid precursors testosterone associated peripheral cortisol levels reflecting adrenal function determine potential correlations investigated sulfate total testosterone free testosterone sex hormone binding globulin anti hormone thyroid stimulating hormone tsh series multivariate logistic regression analyses utilizing either continuous variable cut continuous variable practically models demonstrated significant peripheral sex hormone precursors levels demonstrating strongest consistent individual parameter part ratio conclude women peripheral sex hormone precursors especially reflect levels therefore adrenal function women ages low levels sex hormone precursors therefore considered indications adrenal assessments elsevier ltd rights reserved
gut microbiota includes community bacteria play integral part host health biological processes pronounced repeated findings linked gut microbiome stress anxiety depression currently however remains limited set studies focusing microbiota change substance abuse including alcohol use disorder date studies investigated impact alcohol administration gut microbiome research gut microbiota addiction proceed understanding route drug administration affects gut microbiota first established animal models alcohol abuse proven valuable elucidating biological processes involved addiction alcohol related diseases first study investigate effect route ethanol administration gut microbiota mice adult male mice exposed weeks chronic intermittent ethanol air control faecal samples collected end exposure followed sequencing bioinformatic analysis robust separation control seen microbiome assessed alpha beta diversity notable decrease alpha diversity results demonstrate exposure markedly alters gut microbiota mice significant increases genus significant reductions clostridium seen mice control findings support viability method studies investigating microbiota gut brain axis align previous research showing similar microbiota alterations inflammatory states alcoholic hepatitis psychological stress elsevier rights reserved
background evidence indicates substance related cognitive biases attentional memory approach bias contribute maintenance development substance misuse impulsivity suggested influence cognitive biases contribute substance misuse possibly incentive salience attribution processes however strength moderators relationship impulsivity substance related cognitive biases yet empirically examined methods meta analysis using random effects models completed assessing studies reported quantitative relationship impulsivity measure substance related cognitive bias two component impulsivity impulsivity measurement type gender age assessed moderators results small significant positive relationship observed impulsivity substance related attentional memory approach biases moderators examined significant influence relationship conclusions results consistent incentive theories addiction suggests weak synergistic relationship impulsivity substance related cognitive biases relationship holds across different measures components impulsivity results provide support viability impulsivity cognitive bias interaction models warrant investigation factors relation predicting addiction treatment outcomes crown copyright published elsevier ireland ltd reserved
past three decades insights role cerebellum emotional processing substantially increased indeed methodological cerebellar lesion studies major technological advancements field neuroscience particular responsible exponential growth knowledge topic timely review available data critically evaluate current status role cerebellum emotion related domains main aim article present overview current facts ongoing debates relating clinical neuroimaging neurophysiological findings role cerebellum key aspects emotion experts field cerebellar research discuss range cerebellar contributions emotion nine topics topics include role cerebellum perception recognition encoding emotional information experience regulation emotional states relation motor cognitive social behaviors addition perspectives including cerebellar involvement emotional learning pain emotional aspects speech neuropsychiatric aspects cerebellum mood disorders briefly discussed results consensus paper illustrate theory empirical research produce composite picture brain topography physiology function establishes role cerebellum many aspects emotional processing
industry model predictive control mpc solutions high computational requirements usually implemented based devices main goal study implement mpc algorithm programmable logic controller paper describes initialization part solution represents internal model pre processing algorithm implemented function blocks created programming standard iec pre processing algorithm changes model representation form multivariable system mimo continuous transfer function matrix generalized discrete state space model end paper shown created comfortable interface used transfer functions process model parameterization future mpc tuning interface communicating pre processing algorithm running allows specify mimo internal model continuous transfer function matrix discrete state space internal model used control created automatically operator use matlab mathematical software creation discrete state space representation widespread mathematical description industry known like continuous transfer function used constants transfer functions usually obtained operator current visualizations plant
brushless motors widely used various low power drive applications owing several advantages conventional motors study describes fuzzy logic based improved loss technique motor drive system proposed algorithm uses selective harmonic elimination based pulse width modulation optimise converter switching losses along machine core copper losses based speed load dependent fuzzy rule matrix optimum switching angles eliminating lower order harmonics calculated offline stored microcontroller memory online application suitability proposed control demonstrated simulation experimental results practical machine
present system developed allow people disabilities family members control home environment turn light turn using smartphone user interface designed adjustable needs user development followed iterative user centered design approach paper based low fidelity prototype built based user requirements first authors experience researcher cerebral palsy several design evaluation iterations functional prototype evaluated real context real users preliminary results indicate proposed system suitable people without motor disabilities provides adequate method controlling home appliances family member motor disabilities
among potential environmental harmful factors fungi deserve special consideration intrinsic ability actively infect host tissues determine prominent trigger host defense mechanisms appearance fungi evolutionary history organisms evolve strategies recognize cope existing controversies around hypersensitivity syndrome due great variability clinical symptoms also possible eliciting factors associated hypothesis presented evolutionary analysis different response patterns seen able explain existing variability disease patterns classical interpretation immune responses symptoms addressed within field pathophysiology presented evolutionary analysis seeks ultimate causes vast array symptoms symptoms interpreted induced direct toxic actions fungal metabolites side host initiated response aims fight potentially deleterious effects fungal infection individual susceptibility immune reactions confer response symptoms explained terms ige mediated allergy fits scenario individuals atopic predisposition suffer response exposure studies addressing responses evolved advantageous scarce human history diseases connected exposure explain vulnerability allergy likewise symptoms analyzed possible adaptive role defense active infection also evolved mechanisms avoidance potentially harmful environments evolutionary past present setting
last three decades ample research demonstrate therapy serious juvenile offenders keeping community intensive intervention significantly reduce less severe released therapy provides available parental guidance family therapy individual therapy group therapy educational support quite importantly change peer group new york city new juvenile justice initiative implement interventions keep juvenile offenders community rather sending however paper aims examine teaching prosocial values early childhood reduce incidence first time juvenile programs school project discussed demonstrate although somewhat expensive innovative programs nonetheless quite cost effective cost society victim damages significantly greater along teaching prosocial values renewed interest early identification youth risk developing antisocial personality disorder update given status promising approaches early intervention prevent serious juvenile hence adult
osteoarthritis one frequent pathologies affecting joint evidence use intra articular acid treatment disorder achieves positive effects reduction inflammatory mediators systematic review available evidence regarding regulation inflammatory mediators applying osteoarthritis humans performed web science embase medline scopus databases library search engine trip database searched systematically two thousand eight hundred sixty three related articles found two met selection criteria clinical trials evidence level treatment studies two articles represented population patients articles reported application positive effect regulation inflammatory mediators mediators studied activator system levels nitric oxide limited evidence available suggests application regulates various inflammatory mediators processes nevertheless evidence regard required study specific pathologies assessment clinical parameters molecular studies generating good quality clinical studies larger sample sizes
paper investigate optimal control equation optimal distributed boundary control problems functional analytical approach adopted investigation maximum principles systems necessary optimality conditions respectively presented two kinds optimal control problems fixed free final horizon cases four problems moreover free final horizon case assumptions control set non empty interior removed set including interesting case contains finite many points finally utilize obtained results also made illustration
background androgen receptor splice variant associated resistance hormonal therapy resistant prostate cancer due limitations methods available analysis identification reliable detection method facilitate use biomarker clinical practice objective confirm predictor resistance hormonal therapy develop new approach assess highly sensitive digital droplet polymerase chain reaction plasma derived rna design setting participants plasma samples collected patients began second line hormonal treatment isolated rna extracted analysis outcome measurements statistical analysis absolute target gene concentration copies per copies determined statistical analyses performed spss software usa results limitations total patients received patients found positive median progression free survival significantly longer negative versus patients overall survival significantly shorter participants baseline compared participants reached conclusions study demonstrates plasma derived rna reliable source detected assay also showed resistance hormonal therapy predicted making clinically relevant biomarker patient summary report first study method androgen receptor splice variant detection rna extracted cancer cell vesicles released blood results confirmed role predictive biomarker resistance hormonal therapy assay showed vesicles reliable source rna method fast highly sensitive affordable european association published elsevier rights reserved
study order determine efficiency estimating annual water pollution loads remote sensed land cover classification ground observed hydrological data empirical model investigated remote sensing data imagery national atmospheric administration advanced high resolution applied year water quality dataset different rivers japan six water quality nitrogen total phosphorus biochemical oxygen demand chemical oxygen demand cod dissolved oxygen examined using observed river water quality data generated land cover map cod loads estimated river basins using empirical model calibration validation results showed proposed simulation technique useful predicting water pollution loads river basins found vegetation land cover larger impact export rivers urban areas small impact export rivers relatively large impact export results indicate application land cover data generated remote sensed imagery give useful interpretation river water quality
paper discusses important policies regulations supporting decentralized management harvesting utilization rainwater germany measures increasingly applied last decades development implementation specific policies regulations contributed significantly trend also work incentives development advanced technologies businesses widespread growing implementation measures decentralized rainwater management harvesting utilization public private actors development generally associated environmental economic concerns related required adaptation changes climate demographic structures infrastructures climate resilience including flood control drought resistance addressed supported measures assigned two focus areas decentralized rainwater harvesting utilization aiming saving fresh water resources centrally supplied drinking water decentralized rainwater retention management aiming flood control protection existing infrastructures ecosystems decentralized management rainwater separation combined systems source generally regarded state art basic condition sustainable municipal wastewater management
oral contraceptive pills important element hepatitis virus hcv treatment women childbearing potential studies evaluated safety pharmacokinetic interactions estradiol levonorgestrel lng studies open label single site two period fixed sequence one way interaction studies period subjects received one tablet lng period subjects received daily days daily days one tablet lng day group group study enrolled healthy adult females clinically meaningful effect multiple doses pharmacokinetics lng geometric mean ratios auc max presence absence lng confidence intervals cis contained interval similarly auc max presence absence lng respectively cis auc lng max contained interval however lng auc slightly exceeded upper bound results suggest administered female patients hcv childbearing potential prevent pregnancy
south africa developing country predicted severely impacted physical water scarcity order future water crisis country needs find ways reduce reliance conventional surface water schemes based rivers rainwater harvesting rwh alternative water resource date viability domestic rwh within urban setting adequately considered purpose study thus address detailed modelling representative catchment river catchment town comprising domestic properties covering area around chosen purpose new computational tool urban rainwater stormwater harvesting model developed take best advantage available data analysis showed rwh economically viable minority property owners climate change likely limited impact performance rwh systems contrary claims rwh unreliable means attenuating peak stormwater flows
paper basis new method diagnosis electric motor presented first model motor developed important steps build presented model considers electromagnetic behavior mechanical faults theoretical calculation verified fem model finally simulation results presented
challenge developing computer programming visual language sphere interdisciplinary research philosophy particular philosophy mathematics philosophy language new area analysis philosophy information consider aspect language thinking stages developing interaction person information environment means programs set problem concerning necessity find ways constructing software offer efficient way eliminate distinction system interface software programming language via using visual programming language tool people communicate machine prospects using visual programming languages difficulties creation implementation conclude developing cloud technologies opens new opportunities make cross subject tools creating changing software functionality people without professional programming noted developing using visual languages considerable impact development nano bio technologies research field cognitive management artificial intelligence modeling visual thinking research areas recommend understanding use visual programming languages social psychological aspects
digital proportional integral derivative control systems unknown dynamics data driven output feedback fault tolerant control problem studied paper framework active issue online recursive identification residual generator state observer observability canonical form plant consideration addressed problem reconfiguration data driven fault tolerant compensation controller gain properties also dealt means obtained results equation related infinity control accommodate faults ensure tracking performance resulting fault tolerant compensation control scheme designed based closed loop systems therefore practical significance existing methodologies developed terms open loop systems finally effectiveness proposed approach validated speed control experiment motor
known vasculitis unknown etiology affecting predominantly small medium sized vessels usually involving upper lower respiratory tract kidneys anti neutrophil cytoplasmic autoantibodies probably initial cause inflammatory process leads typical lesions issue european journal immunology report interesting findings possible involvement cell subsets pathogenesis disease prospective study performed large cohort patients identifies lymphocytes possible pathogenic subset treg cells possible inflammatory process two subsets peripheral blood used cellular biomarkers disease activity result particularly useful follow patients immunosuppressive treatment initiated
study evaluated clinical significance fdg pet patients interstitial lung disease ild investigating relationships fdg pet parameters clinical indicators evaluating prognostic implications fdg pet results methods ninety patients men women mean age age range ild underwent fdg pet retrospectively analyzed defined mean less affected lung field adjusted using tissue fraction mean attenuation corresponding region interest high resolution compared ild patients age sex matched controls correlations clinical indicators including estimated percentage forced vital capacity fvc estimated percentage diffusion capacity lungs carbon monoxide carbohydrate antigen von surfactant protein reactive protein crp lactate dehydrogenase ldh ild sex age physiology gap index evaluated using spearman rank correlation test test cox proportional hazards model used univariate multivariate analyses factors associated lung transplantation free survival results significantly higher ild patients healthy controls except patients interstitial pneumonia pattern significantly correlated fvc significantly correlated ldh weakly correlated crp univariate analysis showed sex fvc ild gap index significantly prognostic lung transplantation free survival multivariate analysis showed ild gap index independently prognostic lung transplantation free survival higher indicated poorer prognosis especially patients moderate risk based ild gap index conclusion significantly moderately correlated clinical indicators providing independent prognostic information patients ild fdg pet helpful monitoring risk stratification ild patients
background house dust mite allergies common often allergies occur patient due homology potentially shared proteins aim study assess frequency house dust mite sensitization allergic canadian population methods undertook retrospective chart review allergic patients outpatient allergy clinic ontario canada primary endpoint assess presence sensitization population patients categorized approximate assessed severity reactions correlated skin test size skin test size measured proportion patients atopic symptoms results identified allergic patients tested house dust mite patients positive skin test patients skin test times likely exhibit dust mite skin test patients skin test odds patient skin test larger skin test times odds patient skin test size find correlation skin test size reaction symptom grade conclusion canadian patients found large majority allergic patients sensitized found patients large skin test likely large skin test compared patients small skin test find correlation skin test size reaction symptom severity patients symptoms rhinitis asthma caused house dust mite allergy
clostridium serious epidemiological problem particularly dangerous causing hospital infections currently treatment infections use however patients recurrent infection difficult treat occurs fecal microbiota transplantation new method used treat recurrent consists infusion fecal suspension healthy donor gastrointestinal tract patient restore natural intestinal safe effective treatment recurrent extensively described around world date two randomized studies confirming effectiveness conducted method also applied treatment diseases colitis ulcerative colitis crohns disease irritable bowel syndrome review describes procedure current state knowledge effectiveness treatment recurrent
permanent magnet synchronous motors widely involved electric electric cooling strategy still challenge designers paper proposed novel thermal management approach phase change material pcm applied actuator systems aircraft simplified model special paraffin pcm built finite element method impact paraffin cavity configurations paraffin types transient cooling effect simulated analyzed conditions various heat load duty cycles different ambient temperatures results suggest replacing motor paraffin based effective time temperature control prolonged approximate motor works continuous mode peak temperature decreased operates periodic mode elsevier ltd rights reserved
background platelet endothelial aggregation receptor membrane protein highly expressed platelets endothelial cells plays role platelet contact induced activation sustained platelet aggregation endothelial function previous reports variant influencing risk patients coronary heart disease investigated whether genetic variation predicts cardiovascular outcome white population methods participants enrolled study environment genes health outcomes women mean age years genotyped snps measured baseline cardiovascular risk factors recorded cardiovascular disease incidence snps contrasted cardiovascular disease incidence minor allele variant major allele reference haplotypes carriers non carriers adjusted analyses accounted family clusters baseline including sex age body mass index mean arterial pressure total hdl cholesterol ratio smoking drinking drug treatment history cardiovascular disease diabetes mellitus results median follow years died experienced major cardiovascular endpoint multivariable adjusted hazard ratios eight snps including ranged respectively hazard ratios three haplotypes frequency ranged mortality cardiovascular complications results influenced intake antiplatelet drugs anti inflammatory drugs values interaction conclusions white population replicate previous reports experimental studies obtained patients suggesting susceptibility gene cardiovascular complications
biological specimens cells tissues urine blood contain mixtures many different biomolecules contribute raman spectrum given point separation identification pure biochemical components remains one biggest challenges raman spectroscopy multivariate curve resolution matrix factorization method powerful yet flexible method used constraints non negativity decompose complex spectroscopic data matrix small number physically meaningful pure spectral components along relative paper reviews recent applications multivariate curve resolution alternating least squares analysis raman spectroscopic imaging data obtained either vivo vitro biological medical samples
paper data aggregation gateway framework constrained application protocol group communications proposed framework designed improve throughput performance energy efficiency group communication monitor control multiple sensor devices collectively single user terminal consists four function blocks message analyzer group manager message data three informative databases client database resource database information database performs group management group communication functional block stores resources informative databases employs international standard based data structures provides interoperability heterogeneous devices used various applications implemented using java based open source framework called evaluate functions performance experiment results showed framework revealed better performance existing group communication methods terms throughput energy consumption
objectives summarize synthesize growing gene environment research investigating promoter region serotonin transporter gene eating disorders field overcome common limitation low sample size systematic review followed secondary data meta analysis studies identified review method systematic review articles using psycinfo pubmed embase undertaken identify studies investigating interaction environmental psychological factor related outcome variable seven studies identified systematic review complete data sets five community female two clinical female samples combined perform four secondary data analyses traumatic life events predict status sexual physical abuse predict symptoms depression predict symptoms predict disordered eating results model low function allele interacted traumatic life events experiencing sexual physical abuse one predict increased likelihood symptoms respectively however additive model also interaction sexual physical abuse considered independently interaction traumatic life events interactions significant conclusion early promising results followed continued cross institutional collaboration order achieve large sample sizes necessary genetic research elsevier ltd rights reserved
first characterized female roles victims broadcast television network changed image including leading female roles drug dealing seemingly investment traditional gender roles women turn active agent world nevertheless defined means feminine elements way two analyzed real act characters order gender prototypes abilities analyze decide rather consider victims circumstances assume responsibility life chosen violent acts
due high penetration strong trend towards future energy grids exhibit increasingly emergent behavior consequence new engineering approaches based decentralized decision making proposed agent project provides framework design development testing energy infrastructures however contrast approaches allows designer consider kinds energy electrical power also gas heat shown small scale scenarios developed software artifacts site systems avoids redundancy otherwise created implementing software different systems closing gap simulation environments hybrid hard software test beds real site applications agent project intends demonstrate systematic seamless software development processes according tool chain already viable today
introduction myelofibrosis myeloproliferative neoplasm associated peripheral blood marrow fibrosis splenomegaly systemic symptoms evolution refractory form acute myeloid leukemia treatment inhibitor significantly improves symptom burden reduces degree splenomegaly therapy however results modest prolongation survival disease progression reduce risk transformation novel agents potential alter progressive disease course urgently needed areas covered pre clinical rationale use inhibitor patients advanced essential thrombocythemia reviewed results initial clinical trials agent expert opinion results single institution pilot study therapy reported indicate signal activity approach appears potential reverse bone marrow abnormalities induce molecular responses target malignant hematopoietic stem cell population patients results randomized multi center phase trial ongoing
innovation building information modelling bim technology provides new means predicting managing monitoring environmental impacts project construction development virtual prototyping technology paper aims provide thought insights shortcomings scope existing green bim literature outlines important directions future research total green bim related papers reviewed compared green bim research centres environmental performance design papers construction stages papers building studies concentrated development bim based tools managing environmental performance building maintenance papers papers stages suggested one stop bim environmental sustainability monitoring management buildings full life cycle considered future research future green bim tools also include three concept reduce reuse sustainability analysis new development projects system offer better integration facility operation maintenance effective low carbon management use cloud based bim technology enable management building sustainability using big data also needed despite potential developments argued lack computer tools complications bim models adoption green bim elsevier rights reserved
intracellular pathogens survive replicate within membrane bound compartments considered pseudo organelles using intracellular bacterium illustrative example consider modes lipid transport pathogen containing compartments host organelles including formation static membrane contact sites discuss lipid scavenging mediated via reprogramming cellular transporters interfaces describe recent data suggesting pathogen effectors modulate formation specific membrane contacts study emerging mechanisms likely yield new insights cell biology lipid transport communication highlights potential new targets strategies future therapeutics article part special issue entitled cellular lipid landscape authors published elsevier
background although metals adversely impact childrens health distribution exposures many metals particularly among vulnerable subpopulations characterized objectives sought determine whether neighborhood deprivation associated urinary concentrations thirteen metals whether observed relationships varied race ethnicity methods obtained neighborhood characteristics american community survey demographic information urine samples healthy young girls northern california obtained clinical visit urine samples analyzed metals using coupled plasma mass spectrometry levels corrected creatinine analysis variance generalized linear regression models estimate associations urinary metal concentrations neighborhood deprivation race ethnicity stratified multivariable models evaluate possible interactions among predictors metals concentrations results urinary concentrations three metals lead varied significantly across neighborhood deprivation four lead tin varied across race ethnicity groups models adjusted family income race ethnicity neighborhood deprivation associated concentrations neither associated lead tin concentrations examining neighborhood deprivation within race ethnicity groups levels interaction decreased neighborhood deprivation among hispanic girls trend lead levels interaction increased neighborhood deprivation among asian girls trend conclusions results indicate childrens vulnerability metals varies neighborhood deprivation quartile race ethnicity differential distributions exposures contribute environmental health disparities later life published elsevier ltd
purpose main objective study evaluate effectiveness injection plasma rich platelet derived growth factors versus acid following surgery patients diagnosed internal joint osteoarthritis materials methods total patients randomised two study groups group received injection group received injection mean age years range years patients women pain intensity visual analogue scale extent maximum mouth opening procedure statistically analysed results better results observed group treated significant reduction pain months compared treatment regarding mouth opening increase observed groups significant difference conclusions injection following effective injection respect pain patients advanced internal european association facial surgery published elsevier ltd rights reserved
goal intrusion detection system ids monitor activities detect security policies computer system network paper focuses anomaly detection paradigm ids goal anomaly based ids classify intrusion based system network activities outside normal region paper employ multiple detector set artificial immune system variation artificial immune system classify intrusion based features application layer protocols http etc network data flows result shows multiple detector set artificial immune system achieved detection rate false positive rate achieved accuracy
understanding fractions many students research based knowledge fractions utility linear representation broadly influenced instruction randomized trial study supported mathematical resources assigned teams across united states locally managed study supported fractions study resource kit control conditions educators elementary teachers self managed learning month period analyses indicated significantly greater improvement educators students fractions knowledge teams randomly assigned study resource kits results suggest integrating research based resources study offers new approach problem scale combining strengths teacher leadership research based knowledge
new data driven model developed determine particle size distribution measured length distribution data structure model consists three steps first measured compressed small set parameters second parameters correlated low order moments small number using regression models third low order moments used input variables two layer network sub model built predict form histogram two key aspects modeling strategy noteworthy namely construction specialized parameterized functions herein called generating functions reduce number parameters needed train models two layer network component ability model size distribution demonstrate paradigm model used determine particles morphology shown even limited data set models trained predict generated laser diffraction minor size generated image analysis minor major measured image analysis elsevier ltd rights reserved
parabolic trough solar power plants use thermal fluid transfer thermal energy solar radiation water steam rankine cycle order drive turbine coupled electrical generator produces electricity plants heat transfer fluid system necessary elements transform solar radiation heat transfer thermal energy water steam order get best possible performance rankine cycle hence thermal plant necessary thermal fluid reach maximum temperature leaving solar field also mandatory thermal fluid exceed maximum operating temperature noted optimal temperature thermal fluid difficult obtain since solar radiation change one moment another aim document provide model system used optimize control temperature fluid without interfering normal operation plant results obtained model contrasted obtained real plant
syndrome severe neurodegenerative disease heterogeneous genetic etiology report novel variant mitochondrial gene child syndrome mitochondrial proliferation lactic abnormal respiratory chain enzymology variant present blood cultured fibroblasts pathogenic mutation causing syndrome elsevier mitochondria research society rights reserved
plant parasitic developed series enzymes degrade rigid plant cell wall beta important component migratory molecular data published two novel beta cloned characterised putative protein consists signal peptide catalytic domain carbohydrate binding module contrast domain absent exon intron structure phylogenetic tree indicate genes evolved common genes southern blotting confirmed beta origin member small multi gene family situ expression glands pcr showed genes expressed adult female second stage juvenile showed clear activity plate assay similar results observed total recombinant proteins results demonstrated produce functional silencing putative beta double stranded rna resulted average decrease infection successful rnai vitro demonstrated study confirmed play important roles
paradoxical reaction treatment rare paediatric population report year old girl high fever productive cough last three weeks test positive erythrocyte sedimentation rate culture polymerase chain reaction tuberculosis negative chest ray showed right tuberculosis diagnosed therefore treatment standard doses started twenty one days later presented high fever symptoms worsening radiological findings normal blood tests brain magnetic resonance imaging patient presented paradoxical reaction given day fever disappeared hours important consider paradoxical reaction causes clinical radiological worsening ruled avoid unnecessary tests treatment modifications
extensive small signal analysis voltage mode controlled dual boost converter operating continuous current mode based signal flow graph approach proposed small signal flow graph developed open loop small signal transfer functions derived using known gain formula closed loop small signal input output control output transfer functions also derived frequency response characteristics determined different duty ratios voltage mode compensator designed using factor approach used closed loop operation converter load voltage regulation supply voltage load disturbances demonstrated experimental results elsevier science ltd rights reserved
behavioral disorders highly prevalent patients neurological diseases explained cognitive impairments fact underlying mechanisms poorly understood given functioning underlies appropriate behavior impairments contribute appearance behavioral disorders investigate issue performed five patients suffering various neurological diseases alzheimers disease parkinsons disease frontotemporal degeneration stroke included study patients comprehensively assessed terms cognitive behavioral disorders processes facial emotion recognition theory mind seen cognitive behavioral impairments prevalence impairments varied according diagnosis stepwise logistic regressions showed cognitive executive indices predicted theory mind impairments predicted hyperactivity impulsivity behaviors iii impaired facial emotion recognition predicted social behavior disorders several behavioral disorders associated underlying impairment processes cognitive indices executive functioning except results strongly suggest behavioral disorders signs underlying impairment processes
primary continued improvement traditional charge based electronic devices accordance law excessive energy dissipation takes place devices switching bits one promising solution utilize strain mediated composites strain coupled piezoelectric layer magnetization switched two stable states sub delay amount energy room temperature apart digital memory logic devices also utilized analog signal processing voltage amplifier first briefly review recent advances devices show possible achieve called limit ultimate limit energy dissipation amount compensating entropy loss thereby linking information thermodynamics
ability infer mental states others explain complex behavior ambiguous social situation called advanced theory mind atom relations two components atom cognitive affective measured behavioral level polish year olds year olds examined role age gender friendship style relations cognitive affective atom explored cognitive atom weakly moderately related affective atom across age groups females scored higher males males atom abilities differ according age scored higher cognitive atom affective tom also different aspects friendship style significant predictors atom abilities implications two atom components within gendered social context discussed foundation professionals services adolescents published elsevier ltd rights reserved
dietary supplements contain macro also elements affect human metabolism many products available market contain compounds together chitosan used dietary supplement enhancing digestion lipids studies involved natural chitosan available market degree dietary supplements containing chitosan nutrition product containing ionic several study determined capability binding fatty bile acids dietary supplements containing chitosan process lipids bile acids adsorption investigated means dynamic method model vitro conditions findings prove extracts fatty acids bile acids undergo adsorption various kinds adjuvant substances found dietary supplements confirms significant effect polymers bioavailability fatty bile acids human organism addition supplement effect capability chitosan bind fatty bile acids mean adsorption bile acids polymer chitosan fibre ranges depending decreases bioavailability lipids
background implicit biases involve associations outside conscious awareness lead negative evaluation person basis irrelevant characteristics race gender review examines evidence healthcare professionals display implicit biases towards patients methods pubmed cinahl searched peer reviewed articles published march march two reviewers assessed eligibility identified papers based precise content quality criteria references eligible papers examined identify eligible studies results forty two articles identified eligible seventeen used implicit measure implicit association test fifteen priming two test biases healthcare professionals twenty five articles employed subjects design using examine influence patient characteristics healthcare professionals attitudes diagnoses treatment decisions second method included although isolate implicit attitudes recognised psychologists implicit cognition way detecting possible presence implicit bias twenty seven studies examined racial ethnic biases ten biases investigated including gender age weight thirty five articles found evidence implicit bias healthcare professionals studies investigated correlations found significant positive relationship level implicit bias lower quality care discussion evidence indicates healthcare professionals exhibit levels implicit bias wider population interactions multiple patient characteristics healthcare professional patient characteristics reveal complexity phenomenon implicit bias influence clinician patient interaction convincing studies review combine method measuring quality treatment actual world correlational evidence indicates biases likely influence diagnosis treatment decisions levels care circumstances need investigated review also indicates sometimes gap norm extent healthcare professionals tested characteristics conclusions findings highlight need healthcare profession address role implicit biases disparities healthcare research actual care settings greater homogeneity methods employed test implicit biases healthcare needed
paper deals torque ripple minimization using degree offered doubly fed induction machine employed electrical propulsion various strategies carried analysis reduction torques torque reduced either machine design control methods authors introduce new technique decrease torque using control strategy simulation results experimental tests presented discussed
gut microbiome contributes approximately whole body weight recent studies suggest gut microbiota profound effect human metabolism potentially contributing several features metabolic syndrome metabolic syndrome defined clustering metabolic disorders include central adiposity visceral fat accumulation dyslipidemia insulin resistance non optimal blood pressure levels metabolic syndrome associated increased risk cardiovascular diseases type diabetes estimated around percent worlds adult population metabolic syndrome manuscript reviewed existing data linking gut microbiome metabolic syndrome existing evidence studies animals humans support link gut microbiome various components metabolic syndrome possible pathways include involvement energy homeostasis metabolic processes modulation inflammatory signaling pathways immune system interference angiotensin system modification gut microbiota via probiotics dietary interventions provided evidence support possible beneficial effect interventions targeting gut microbiota modulation treat components complications metabolic syndrome diabetes india published elsevier ltd rights reserved
combined suspended particle device vacuum potential adaptive low energy building application transmission essential parameter determine indoor comfort level building due work index strong correlation transmission index atmospheric transmission evaluated south facing vertical plane index diffuse dominant one single value transmission found suitable building energy calculation throughout year index south facing vertical plane vacuum transmission transparent states respectively
objective mixed arts increasingly popular sport involving aggressive techniques present substantial injury risk examined incidence types injuries sustained compared injuries sustained matches design consecutive case series setting used data post fight medical examinations canada participants participants main outcome measures attending physician conducted mandatory post fight examination documented nature injuries sustained results significantly likely experience injury whereas significantly likely experience injury typically likely experience loss consciousness serious eye injury conclusions overall injury incidence appears slightly higher experience minor injuries likely experience serious injury head trauma involving loss consciousness eye injury retinal
tight gas reservoirs prominent importance among petroleum reservoirs due complicated flow dynamics gas tight porous media effects corrections applied equation properly predict gas flow dynamics mean pore diameter tight decreases ratio mean free path pore diameter known non dimensional number rises gas effects becomes important condition slip pore surface proper treatments complexities attempted using classical continuum fluid mechanics kinetic theory gases approaches known slip condition correction presented many researchers tried correct extend model beyond slip flow regime research slip condition gas low permeability simple porous media studied lattice boltzmann method new corrections coefficients investigated corrections allow extension model higher ranges numbers simulations work performed codes developed authors elsevier rights reserved
background ras related protein functions either oncogene tumor suppressor cancer type dependent manner aimed investigate clinical significance prostate cancer pca methods quantitative real time polymerase chain reaction western blot immunohistochemistry respectively performed detect mrna protein expression pca adjacent non cancerous prostate tissues receiver operating characteristic curve analysis used evaluate predictive diagnostic value associations expression various clinicopathological characteristics biochemical recurrence free survival pca patients statistically evaluated vitro pca cell proliferation assessed assay cell migration invasion activities evaluated transwell assay following transfection small interfering rna results ras related protein mrna protein expression pca tissues significantly higher adjacent non cancerous prostate tissues area curve immunoreactive score sensitivity specificity high significantly associated high score distant metastasis pca patients high shorter overall biochemical recurrence free low cox regression analysis identified independent biomarker overall biochemical recurrence free pca patients exploring activities vitro downregulation found inhibit pca cell proliferation migration invasion conclusions high expression contribute malignant progression biochemical recurrence pca patients radical
fully polynomial time approximation scheme class approximation algorithms optimisation problems able deliver approximate solution within chosen ratio polynomial time thinning theorem property three come generic strategy constructing fold based greedy thinning approximation algorithms thus seen series components needed constructing often natural extensions thinning algorithm design complex thus made easier resulting algorithms turn simpler previous works elsevier rights reserved
study conducted embryo days gestation divided group days group days group iii days group days group days gestation group whole embryo processed serial sections cut whereas rest groups pelvic tissues representative areas used study days gestation pelvic present form smooth cylindrical tube approximately length gland gland appeared days gestation junction neck urinary bladder pelvic junction pelvic respectively length width height circumference pelvic increased increased gestation period however length times circumference times increased maximum group group parameters length width height circumference pelvic significantly correlated age weight throughout gestation period present form days gestation became distinct days gestation histologically days gestation sinus present cluster cells days gestation process started wall pelvic started first part four layers mucosa distinct lumen layers stratified group group iii days gestation beyond distinct transitional epithelium present formation spaces started days gestation number size increased increased gestation period thickness increased advancement age whereas height epithelium decreased
paper global operating point dependent losses induction machines studied using local transient loss formulation level flux machine operated depends operation mode inverter hence precise loss modeling inverter driven induction machines machine design stage time spatial distribution flux density influence choosing best operating point included loss scaling method developed map iron losses calculated single synchronous frequency frequencies along torque speed map modeled losses operating points compared extensive machine measurements way example effect different electrical steel grades tailored either low losses preferable machine performance investigated
project manager resource allocation using resource algorithms assigning resources project activities however resource ensure optimized allocation resources furthermore duration cost project increase resources objectives resource allocation optimization used research increase resource utilization decrease project cost iii decrease project duration implemented three search based software engineering algorithms multiobjective genetic algorithm multiobjective particle swarm algorithm elicit sorting evolutionary strategy twelve experiments optimize resource allocation performed published case study experimental results analyzed compared form pareto average pareto percent increase resource utilization percent decrease project cost percent decrease project duration experimental results show best technique resource optimization optimization resource utilization increased project cost duration reduced
internet protocol serious problem internet attractive technique wish amplify network attacks retain many approaches proposed prevent attacks however address significant deployment issue filtering caused lack deployment incentives attacks effectively one mechanism widely deployed network however majority mechanisms unsuitable solve deployment issue mechanism work separately however defensive power considerably weak deployed coordinate partially deployed mechanisms work together demonstrate considerably superior performance creating synergy effect overcomes limited deployment therefore propose universal mechanism incorporates existing mechanisms attacks proposed mechanism intermediate utilize existing anti mechanism ascertain packet records decision packet edge victim network estimate packet based information sent upstream results experiments conducted real internet topologies indicate reduces false alarms compared case mechanism operates individually
todays advances materials science technology lead better buildings improved energy efficiency indoor conditions particular attention directed towards windows glass known current practices often lead huge energy expenditures related excessive inflow outflow energy need balanced energy intensive cooling heating review article outlines recent progress deals materials whose optical properties strongly dependent temperature particular discuss oxide based thin surface coatings thin films nanoparticle composites deposited onto glass able regulate throughput solar energy visible properties remain less another implementation materials incorporating nanoparticles thin films nanocomposites based dioxide able change properties within narrow temperature range vicinity room temperature either reflects infrared light elevated temperatures whereas reflectance much smaller lower temperatures review outlines state art thin films nanocomposites particular attention recent developments taken place laboratories worldwide specifically first set scene discussing environmental challenges relationship present key properties thin film form nanoparticles next part article gives perspectives manufacturing films particles point properties pure fully adequate buildings elaborate additives layers protective coatings employed yield improved performance durability make considerable interest building related applications finally briefly describe recent developments towards light scattering draw final conclusions
purpose investigation cell tumors ovary rare usually presenting women second third decade life less patients older age authors present series cases managed institution materials methods retrospective review performed cases ovarian diagnosed tertiary care institution demographic data clinical presentation pathological findings treatment modalities collected results patients diagnosed year period nine patients postmenopausal time diagnosis median age years iqr years nine patients median interval years iqr since onset menopause presenting feature five median age iqr whereas postmenopausal bleeding noted two diagnosis tumor grade varied poorly differentiated lesions eight patients received adjuvant chemotherapy disease free survival median follow months iqr months without recurrence conclusion present patient population older described literature majority postmenopausal authors knowledge largest series postmenopausal patients evident small sub group definitive management remains controversial varied prognosis risk recurrence
purpose diabetes mellitus chronic metabolic disorder often leads complications aimed correlate two complications bladder syndrome using noninvasive measures screening tests methods included female male type diabetic patients prospective study diabetic evaluations conducted using questions overactive bladder oab evaluations performed using overactive bladder questionnaire oab patients also evaluated nephropathy diabetic male female patients without oab chosen compared microvascular complications nephropathy results significant correlations oab oab nephropathy among diabetic patients female patients male patients however patients oab significantly likely develop female patients male patients conclusions diabetic patients oab diabetic peripheral neuropathy significantly correlated correlations demonstrated using short valid reliable disease specific tests without invasive measures using screening tests easily diagnose complications
studies based highly polymorphic gene human leukocyte antigen hla provide useful information bone marrow donor registry forensic medicine disease association studies infertility treatment designing peptide vaccines tumors infectious autoimmune diseases aim study determine hla hla allele frequencies unrelated individuals province iran finally compared previously described iranian population commercial hla type kits bag germany company used determination hla hla allele frequencies genomic dna based polymerase chain reaction sequence specific primer pcr assay differences populations distribution hla hla alleles estimated chi squared test correction frequent hla alleles frequent hla alleles population hla hla least observed frequencies population results based hla hla allele frequencies showed population possesses previously reported general features still unique published elsevier inc
possibly causal relationship multiple sclerosis chronic cerebrospinal venous insufficiency recently hypothesized studies investigating chronic cerebrospinal venous insufficiency reported conflicting results employed multiple diagnostic imaging modalities across large patient control population study three complementary imaging modalities used investigate chronic cerebrospinal venous insufficiency hypothesis patients multiple sclerosis two age sex matched control groups healthy volunteers patients neurological diseases strictly blinded doppler ultrasound according original chronic cerebrospinal venous insufficiency hypothesis four dimensional flow magnetic resonance imaging venous flow head neck chest contrast enhanced magnetic resonance neck chest venous acquired internal vein stenosis evaluation also performed across modalities percentage subjects meeting ultrasound based chronic cerebrospinal venous insufficiency criteria small similar groups group wise pairwise testing four dimensional flow magnetic resonance imaging variables statistically significantly different measurement location contrast enhanced magnetic resonance internal veins statistically significant differences observed stenosis scores groups results represent compelling evidence chronic cerebrospinal venous insufficiency hypothesis multiple sclerosis
rat species chromosome genus relationship two species lacking chromosome mammalian sex determining gene unknown furthermore little cytogenetic analysis sex chromosomes therefore constructed molecular phylogenetic trees nucleotide sequences trees strongly supported first indicating loss chromosome occurred common two species found chromosomes consisted large regions conducting analyses pcr southern blotting fish revealed males multiple copies long arm chromosome least three sequences contained complete open reading frame orf species specific substitution alanine serine found copies dna binding surface within box suggesting occurred original
purpose review small intestinal bacterial proposed cause irritable bowel syndrome ibs however relationship subject controversy review aims provide current perspective ibs hypothesis recent findings case control studies evaluating prevalence ibs healthy individuals shown conflicting results moreover tests available routine clinical practice diagnose valid lack sensitivity specificity hence interpreting effect interventions based tests uncertainty furthermore ibs hypothesis way assess antibiotic therapy ibs antibiotic showing modest significant clinical benefit however individuals tested mechanism action ibs remains elucidated preliminary data suggest decreases microbial richness previous studies noted antibacterial interventions ibs reduce colonic fermentation improve symptoms advent rapid culture independent molecular techniques promising tool seek clarify advance understanding gut microbial function summary ibs hypothesis lacks convincing evidence remains mechanism resulting symptom improvement treatment ibs individuals requires exploration novel molecular techniques provide exciting challenging opportunity explore host gut microbiota interaction
paper present analysis voltage amplifier needed double differential measurements novel simple circuit implementing active electrodes three input amplifier standalone active electrodes require inherently different differential amplifier general knowledge design scarce literature first figures merit amplifier defined decomposition input signal three orthogonal modes analysis reveals mode containing crosstalk components electrode reject effect finite input impedance analyzed three terminals minimum bounds interference rejection ratios due electrode input impedance two degrees freedom obtained finally novel circuit design presented including operational amplifier passive components design nearly simple electrode much simpler three instrumentation amplifier design providing robust crosstalk rejection better input impedance using unity gain electrode input interference rejection limits input stage analyzed easily implementation proposed circuit described together parameter design guideline adjust specific needs electrode compared established alternatives sample signals obtained acquired different body locations dry contacts successfully interference sources
impacts two plants apple nutrient change behaviors kinetics alkaline phosphatase water studied paper experiment contained six different treatment systems conducted october november total removal rates total nitrogen total chlorophyll contents respectively function organic hydrolysis decreased terms lower velocity reaction lower max water combined lower affinity substrate higher values interstitial water surface sediment contrary exhibited activation alkaline phosphatase water body higher max lower values interstitial water higher max sediment higher max despite high concentrations obvious correlation found alkaline phosphatase activity study indicated induction repression mechanism work water additionally remarkable feature coupled plants water column due plants food source study highlighted investigate enzymology mechanism systems give implications restoration water using floating bed systems
purpose details regarding risk factors onset outcomes related sparse study examines clinical characteristics operative non operative therapeutic outcomes patients previously exposed methods retrospective medical record review conducted data collected including clinical findings management healing outcomes histologic micro computed tomography analyses results seventeen patients treated doses onset majority lesions observed sites dental dental sixteen patients managed non either major minor surgery included follow analysis complete healing significant patients treated major surgery compared non operative group discontinued non operative patients major surgery patients effect healing histologic findings patients analyzed exhibited decreased number micro patients scanned revealed trabecular thickening conclusion lesions occurred mostly sites mean doses major surgery demonstrated complete healing non operative management cessation improve healing outcomes european association facial surgery published elsevier ltd rights reserved
introduction although contraceptive options women expanded considerably last decade methods often offered women choices clinicians informed limiting ability women control fertility areas covered areas covered include use instead improved utilised hormonal contraceptives new delivery systems enabled development long acting methods require less action part user thereby reduce failure rates effective emergency contraceptive methods become readily available counter however male contraception despite much research still remains elusive expert opinion manuscript provide assessment recent advances controversies contraception make suggestions improved availability
purpose initiative determine effects skin testing antimicrobial perspective described summary allergy one frequently reported however self reports allergy accurate incorrect allergies therefore significant barrier antimicrobial important clinical economic implications including increased antimicrobial resistance increased overall cost care increased length stay ultimately increased mortality part antimicrobial program community health system launched initiative order optimize therapy reduce adverse events acquisition costs minimize development antibiotic resistance involves use standardized protocol assessment hypersensitivity patients suspected allergy among patients completed protocol eight month period negative result patients conversion antimicrobial therapy implemented direct result conclusion patients self reported allergy led reduction use broad spectrum agents within health system decrease drug costs documented sample patients switched
fungus one important contributors decline populations worldwide evidence indicates infection depends species life stage fungus strain season environmental factors present paper experimentally investigated susceptibility sensitivity five south american species foreign strain response two populations native strain iii virulence native foreign isolates species also evaluated relationship infection loss found species except susceptible infection lethal consequences sensitive species sensitivity infection depended population strain although relationship found fungal infection loss first experimental study mortality rates south american exposed
ambulatory senior health clinic developed using chronic care model emphasis interdisciplinary team approach determine effect care model approach healthcare system observational longitudinal panel study community dwelling medicare beneficiaries performed examine effect physical function health related quality life participants study recruited community sample eligible medicare beneficiaries informed consent baseline data obtained individuals recruitment response rate complete data across months completion response rate participants receiving care based senior healthcare practice compared patients primary care physicians supported care managers group without care managers self reported data collected telephone measure physical function baseline months multiple group mixture growth model used analyze physical function across months physical function mean scores decreased across time participants moderately correlated wave correlation coefficient two latent growth classes identified class physical function decreased remained stable across time class physical function decreased parallel ninety seven percent intervention group patients class patients comparison groups class despite physical function decline patients senior health clinic care model maintained time whereas patients receiving traditional care physical function decline interdisciplinary team approach appears positive effect population
purpose perform validation brazilian version voice disability coping questionnaire using procedures according scientific committee medical outcomes trust psychometric analyses determine scales validity reliability methods preliminary procedures administered patients determine items culturally valid propose possible adaptations sample study consisted data set individuals vocal complaint comprising men women mean age years without vocal complaint comprising men women mean age years demonstrate validity scores compared vocal self assessment perceptual analysis determine reliability test retest reproducibility voice patients repeated measurement days first administration results principal component analyses patients vocal complaint yielded four coping strategies support seeking avoidant acceptance subscales questionnaire showed acceptable internal consistency reproducibility values apart subscale validity demonstrated relationships perceptual analyses vocal self assessment subscale score differences two groups conclusions submitted essential steps necessary cultural adaptation validation simple instrument shows specific evaluating patients voice problems important addition voice evaluation patients
cells proliferation crucial nerve regeneration following nerve injury study aims investigate effects interleukin proliferation vitro corresponding mechanism rat treated rat cell proliferation apoptosis detected using fluorescent staining flow cytometry transcriptome sequencing raw reads filtered mapped reference genome differentially expressed genes long non coding rnas control groups identified tool functional pathway enrichment analyses performed tool protein protein interaction ppi network constructed tool string furthermore pearsons correlations analyzed regulatory network transcription factors constructed significantly inhibited proliferation value promoted apoptosis cells totally identified among hub genes ppi network regulated enriched apoptosis related terms whereas regulated enriched proliferation related terms like correlated multiple enriched cell cycle division moreover regulated play crucial roles regulatory network regulatory pathways identified treatment influence proliferation apoptosis via regulating gene pathways however studies required confirm results
vehicles drive affected motion dynamics longitudinal directions primarily driving wheels slip acceleration drive wheel due maximum value electric motor driving torque wheels acceleration another problem low frequency vibration mechanical parts propulsion system step changes electric motor torque paper presents algorithm electric drive system interacting motion dynamics electric car
background misuse containing medicines emerging public health issue aims present application cognitive developmental model substance abuse trajectory legitimate use pain towards therapeutic forms misuse physical psychological dependence illustrates cognitive behavioural analysis experiences surfaces specific beliefs thoughts emotions behaviours group hidden dependent individuals distinct unique opioid dependent cohorts method depth one one interviews dependent individuals ireland south africa analysed applied cognitive developmental model substance abuse results misuse dependence pathways maintained interplay physiological determinants relating pain withdrawal tolerance psychological influences therapeutic need pre anticipated physical pain effect relief emotional distress progression towards habitual use misuse therapeutic purposes appears mediated external environmental triggers pertaining availability internal meta cognitions around physical pain emotional distress increasing importance life user conclusion concept mapping misuse dependence presented provide psychological therapists working individuals experiencing problems dependence enhanced understanding key concepts involved misuse recovery pathways
thought represent peculiar response stimuli somatosensory pathways shared pain activation specific neurons receptors occur association dermatological systemic neurological diseases side effect certain drugs however patients suffer chronic idiopathic frequently ascribed psychological distress biomarker available date investigated three families one diagnosed joint syndrome syndrome type eds characterized idiopathic chronic predominantly proximal distribution skin biopsy performed eight affected members revealed six reduced nerve fibre density consistent small fibre neuropathy whole exome sequencing identified two rare variants chronic eight affected members absent non affected members one unrelated sporadic patient type diabetic neuropathy chronic two families diabetic patient carried variant another family carried missense variant variants predicted likely pathogenic silico analyses two variants rare minor allele frequency healthy controls absent small fibre neuropathy eds patients without null allele test cdna patients fibroblasts families carrying variant demonstrated functional due activation mediated rna decay immunofluorescence microscopy western blotting revealed marked reduced synthesis respectively indirect immunofluorescence showed reduced expression skin patients carrying variant treatment provided satisfactory relief patients carrying mutations findings first revealed association gene familiar chronic suggesting new contributor pathogenesis identifying new candidate therapeutic target
recent years significant technological advances changed understanding dynamic processes clinical psychology particularly important agent change ambulatory assessment assessment individuals daily lives combining twin benefits increased ecological validity minimized retrospective biases benefits make particularly suited assessment dynamic processes recent advancements technology providing exciting new opportunities understand processes new ways current article briefly detail capabilities currently offered smartphones mobile physiological devices practical ethical challenges incorporating new technologies research provide several examples recent innovative applications methodology clinical research assessment intervention provide case example data generated study utilizing multiple mobile devices way aim provide sense direction researchers planning studies
maternal immune activation pregnancy rodents increases risk offspring develop schizophrenia related behaviors suggesting relationship immune system brain development tested hypothesis induced viral acid poly early late gestation mice leads behavioral disorders adulthood gestational days pregnant dams treated poly saline via intravenous route offspring behaviors measured adulthood considering progressive structural alterations brain individuals schizophrenia used magnetic resonance imaging mri perform brain morphometric analysis offspring aged one year led increased basal locomotor activity enhanced motor responses drug reduced time spent center arena suggesting increased anxiety like behavior addition reduced glucose preference offspring none treatments altered relative volume lateral however decrease brain volume especially posterior structures observed one year old animals treated poly compared control groups thus activation maternal immune system different lead behavioral alterations possibly related positive negative symptoms schizophrenia results provide insights neurodevelopmental aspects certain schizophrenia published elsevier ltd rights reserved
substitution box box one significant structures used create encryption strong resistant attacks block encryption algorithms box plays important role data encryption paper presents novel box generation algorithm design based scaled chaotic system study new random number generator uses new scaled chaotic system complicated interesting dynamic features designed also new effective strong box design algorithm utilizing random number generator developed bits generated put tests passed tests non linearity bit independence criteria strict criteria differential approximation probability performance tests run proposed box produced new box design algorithm proposed box compared studies available literature proved stronger effective
facilitate self determination received appropriate attention research concerning parents intellectual disabilities likewise parenting interventions adults intellectual disabilities seldom observed parent child behavioural outcomes methodsthis study evaluated effectiveness parenting intervention embedded self determination facilitation practices two dyads parent intellectual disabilities young child interventions focused increasing parents ability correctly implement steps parenting routine reducing occurrence challenging child behaviour resultsthe results study demonstrated two basic effects correctly completed steps parenting routine reduction challenging child behaviour parents also reported decreased feelings stress routine following completion intervention future research replication pilot study discussed
connection rapid increase volume semistructured unstructured data question optimal saving quite important optimal storage important saving convenient format processing resolve issue done review analysis non relational databases applications real example system preservation processing information medicines
apoptosis hundreds proteins cleaved caspase however caspase shares substrate primary sequence preference caspase better poly adp polymerase despite lower intrinsic activity identified key lysine residues within terminal domain caspase critical elements efficient two substrates caspase terminal domain binds improves cleavage chimeric caspase similar fold cellular expression caspase lacking critical lysine residues resulted less efficient cleavage compared cells expressing wild type showed using series caspase positioning enzyme providing mechanistic insight binding summary uncovered role terminal domain terminal peptide caspase promoting key substrate
paper presents novel algorithm architecture design band quasi class proposed design several advantages lower group delay lower computational complexity lower matching error technique developed paper summarized follows simple low pass filter discrete cosine transform modulation utilized generate uniform band first elements replaced pass filters obtain non uniform fast recursive structure variable length algorithm developed efficiently accomplish modulation thus spectrum easily flexibly extended location desired central frequency employing multi rate algorithm band non uniform generated two band sub following proposed design steps parameter compared latest als quasi class design proposed method proposed totally reduction per sample group delay decreased per sample moreover maximum matching error proposed method proposed equal much smaller latest als design proposed variable length modulation registers required hardware implementation applying scheme overall proposed design new solution future applications area hearing aids
three decades since emergence environmental justice movement environmental continue across world include new narratives air water pollution new forms associated climate change energy use natural disasters urban public policies adversely affect socially disadvantaged communities future generations focus issue environmental research provides interdisciplinary conceptual methodological empirical scholarship research policy highlights continuing salience perspective understanding nature society linkages published focus issue address variety environmental issues social multiple countries across world advance research demonstrating environmental emerges particular policies political processes exploring environmental associated industrial pollution documenting exposure various environmental hazards specific urban landscapes discourse continues evolve geographically hope focus issue help establish research next generation scholarship procedural participatory forms
objective quantify cell free fetal dna fetal specific epigenetic marker maternal plasma normal pregnant women weeks gestation assess relationship maternal age height pre pregnancy weight body mass index bmi methods hundred normal pregnant women within gestational age weeks randomly selected grouped five group group group group group weeks maternal plasma dna extracted digested methylation sensitive restriction enzyme fetal specific dna quantified real time polymerase chain reaction qrt pcr results mean concentrations different gestational groups group group group group group copies pearsons correlation analysis showed highly significant positive correlation gestational age bmi also found positively related however show correlation maternal age height pre pregnancy weight conclusions gestational age dependent increase fetal specific epigenetic marker maternal plasma demonstrated indian study group normal pregnant women findings form basis future studies involving pregnancy complications aid early diagnosis placental pathologies
last years learned much pathogenesis diagnosis management intestinal fibrosis patients inflammatory bowel diseases just decade ago intestinal considered inevitable consequence long term inflammation patients respond anti inflammatory therapies inflammatory bowel fibrosis seen irreversible process frequently led intestinal requiring surgical intervention paradigm changed rapidly due approaches become available review mechanisms diagnosis serious complication inflammatory bowel diseases factors predict progression management strategies
application energy storage offshore renewable generation systems allows managing intrinsic uncertainty resources improving utilization factor electrical network optimal storage design algorithms generally evaluate behavior whole system thousands times converging optimal solution reliability results obviously depends quality input data hand utilization simplified storage models design stage reduce simulation time drastically still providing useful information goal paper evaluate applicability methodology sizing energy storage system hybrid wind wave farm based fluid models description performance modeling approach introduced compared standard design procedures based extensive simulations advantages limitations approach impact input data quality discussed
complexity business dynamics often forces decision makers make decisions based subjective mental models reflecting experience however research shown companies perform better apply data driven decision making creates incentive introduce intelligent data based decision models comprehensive support interactive evaluation decision options necessary business environment recently new general explanation methodology proposed supports explanation state art black box prediction models uniform explanations generated level model individual instance support analysis present novel use methodology inside intelligent system real world case business business sales forecasting complex task frequently done users validate assumptions presented explanations test hypotheses using presented parallel graph representation results demonstrate effectiveness usability methodology significant advantage presented method possibility evaluate actions outline general recommendations sales strategy flexibility approach easy follow explanations suitable many different applications documented real world case shows solve decision support problem namely best performing black box models human interaction analysis extend use intelligent systems areas far neglected due models separation machine learning model selection model explanation another significant benefit expert intelligent systems explanations particular prediction model positively influence acceptance new complex models business environment easy assessment switching elsevier ltd rights reserved
stator winding structure manufacturing permanent magnet synchronous machines vital part whole machine design important follow particular procedures order keep winding losses acceptable level include resistance loss additional losses due alternative magnetic flux within area stator winding winding using wire effective way proximity loss suppression sometimes implemented due challenges cost aspects especially low cost solutions case important know consequences using straight non windings relatively high electrical frequency article studies impact number stator winding parallel additional losses distribution slot winding located also thermal condition impacts life time insulation winding analyzed different number parallel current temperature distributions slot attained finite element method fem total losses caused additional losses winding compared measurements results
purpose whilst neural morphological adaptations following resistance training investigated extensively group level relatively little known contribution specific physiological mechanisms pre training strength individual changes strength following training study investigated contribution multiple underpinning neural agonist antagonist morphological variables total volume vol muscle angle pre training strength individual changes strength weeks knee methods twenty eight healthy young men completed weeks knee week maximum voluntary torque assessed pre post simultaneous neural drive agonist antagonist addition vol determined mri mode ultrasound results percentage changes delta correlated delta delta vol pre training delta delta multiple regression analysis revealed total variance delta explained delta delta vol pre training conclusions changes agonist neural drive muscle volume pre training strength combined explain majority variance strength changes knee similar adaptations agonist neural drive important single predictor short term intervention
background contribute musculoskeletal disability joint damage poor health related quality life people aim study examine role variants disease people methods participants fulfilling american association classification criteria recruited primary secondary care attended detailed study visit presence recorded genotyped data analysed according status results compared participants without older longer disease duration higher serum creatinine likely pacific associated however risk alleles single nucleotide polymorphisms snps present frequently effect limited participants pacific significant effect observed western risk allele strongly associated western group eastern group non group associations persisted western group adjusting serum creatinine disease duration including variants regression models conclusions variation function play role development disease populations high prevalence severe
quantify spatial temporal aspects urban heat island effect major city humid sub tropical climate basin fixed station measurements used investigate inter seasonality urban rural differences surface temperature air temperature separately extent spatial variations investigated mobile campaigns satellite remote sensing respectively values dominate pre maximum maximum however different higher daytime values pre little value mainly associated differences urban rural incoming radiative flux pre turn causes difference radiative flux difference modulate value suggested significant correlations pre magnitude also modulated inversely related urban wind speed combination situ remotely sensed model simulation data used show inter seasonality lesser extent related change land use rural site pre periods results suggest degree coupling strong function land use land cover
article compares multiple types child maltreatment among youth seek expand limited knowledge effects multiple types maltreatment depressive symptoms specific latino population emerging studies indicate children exposed one type maltreatment often exposed types study examines predictive strength different multiple types lifetime child maltreatment physical sexual emotional abuse neglect effect youth support parents youth coping youth self esteem place residence depressive symptoms among youth secondary data analyses performed using three annual waves data youth study analytic sample consists year old youth living new york results indicate youth experienced sexual abuse multiple maltreatment types maltreatment physical abuse significant increase depressive symptoms respectively compared without maltreatment place residence exposure violence mental disorders significant risk factors developing psychosocial interventions professionals particularly focus youth report past lifetime experience child maltreatment particular attention given children living new york similar urban low income areas report past lifetime experience multiple types child maltreatment present symptoms diagnosis occurring mental health problems elsevier ltd rights reserved
womens lives menopause source worry anxiety cause certain number physiological changes symptoms possible prevent manage pharmacy elsevier masson sas rights reserved
idiopathic pulmonary fibrosis ipf devastating lung disease median survival ipf upon viral bacterial lung infection although pulmonary infection pneumonia healthy lungs rarely induces fibrosis bacterial lipopolysaccharide lps activates receptor initiating proinflammatory pathways already linked hepatic fibrosis now investigated role ipf fibroblasts lung tissue sections patients ipf analyzed expression isolated normal human lung fibroblasts ipf fibroblasts ipf exposed lps transforming growth factor beta tgf beta expression analysis receptors mediators cytokines expressed fibroblast foci ipf lungs primary ipf model pneumonia lung ipf lps tgf beta whereas produced significantly less connective tissue growth factor upon compared tgf beta stimulation alone ipf showed significantly increased markers compared control fibroblasts although levels prostaglandin elevated responsible effect however significant downregulation tgf beta receptor type control fibroblasts seems contribute reduced response vitro model normal ipf fibroblasts thus differ response upon lps induced stimulation
according attachment theory individual differences adult attachment styles based formed infancy primary caregivers adults form secure feel safe secure relationships form insecure according self compassion theory supported research self compassion attitudes behaviors towards associated variety positive psychological outcomes lack self compassion associated psychological distress additionally fear self compassion negatively associated self compassion current study extend research attachment self compassion examining self compassion fear self compassion mediate two types insecure attachment styles anxious attachment avoidant attachment two indicators emotional distress depression anxiety among korean college students structural equation modeling indicated self compassion independently mediated fear self compassion self compassion mediated paths anxious avoidant attachment depression anxiety expected directions results interpreted perspective korean culture including influence expression self compassion elsevier ltd rights reserved
role trough serum infliximab antibodies toward maintenance treatment remains unclear children aim present study investigate trough identify correlation inflammatory activity clinical response pediatric inflammatory bowel disease ibd cohort investigated trough levels pediatric ibd patients maintenance treatment ninety three blood samples collected demographics reactive protein crp erythrocyte sedimentation rate esr albumin recorded mean trough level mean trough level significantly higher samples taken remission compared active disease trough levels correlated esr crp albumin undetectable eight patients positive active disease surprisingly clinical biochemical remission observed visits correlation dose variations changes trough evident line studies adults trough levels correlated response infliximab
background impairment prediction appreciation choice outcomes contribute several core symptoms asd examined electroencephalography eeg oscillations youth young adults diagnosed autism spectrum disorder asd matched controls performed chance based reward prediction task method analyzed previously published erp data examined theta band oscillations frontal sites within timing window feedback related negativity focused event related changes presentation feedback reward lose outcomes spectral power inter trial phase coherence results reward prediction task groups medial frontal theta power phase coherence greater following lose compared feedback however compared controls inter trial coherence medial frontal theta significantly lower overall across feedback types individuals asd results indicate individuals asd sensitive valence reward feedback comparable peers reduced synchronization medial frontal theta activity feedback processing conclusions finding consistent previous studies showing neural variability asd suggest processes underlying decision making reinforcement learning atypical less efficient asd elsevier ltd rights reserved
increasingly expensive sources energy need energy conservation society major energy consumption contribution operation phase modern buildings systems planned systems provide healthy comfortable indoor environment poor design result energy traditionally design systems based constant number occupants situational awareness system ignored paper focuses intelligence system terms knowledge occupants facility real time thermal comfort analysis applied study indoor climate buildings efficient use systems computational fluid dynamics cfd used model simulate indoor conditions building information modelling bim used platform integrate data apply spatial analysis green building standards embedded bim model evaluate building sustainability based results reasonable allocation individuals location room provided automatic control lighting air conditioning suggested optimize energy consumption based matching occupants comfort level
background aims insulin resistance associated cluster abnormalities increase cardiovascular disease cvd several indices proposed identify individuals insulin resistant thereby increased cvd risk aim study compare abilities indices accomplish goal plasma triglyceride glucose index plasma triglyceride high density lipoprotein cholesterol ratio hdl metabolic syndrome mets methods results population sample individuals women men years old respectively baseline demographic metabolic variables known increase cvd risk incident cvd compared among individuals defined high low risk hdl mets cvd risk profiles appeared comparable high risk subjects irrespective criteria crude incidence cvd events increased high risk subjects subjects years defined hdl subjects years defined subjects years subjects mets area roc curves predict cvd similar hdl respectively however adjusted age sex multiple covariates hazard ratios incident cvd significantly increased high risk patients classified either hdl ratio mets index conclusion although indices identify cvd risk index seems somewhat less effective predicting cvd italian society italian society study atherosclerosis italian society human nutrition department clinical medicine surgery university published elsevier rights reserved
mir family involved fibrosis multiple organs including intestine mir facilitates tgf beta mediated regulation collagen mucosal fibroblasts crohns disease patients myeloid cell leukemia member cell lymphoma bcl apoptosis family involved liver fibrosis targeted mir via utr cultured cell lines investigate role mir primary intestinal fibroblasts tissue patients transfection intestinal fibroblasts pre mir resulted significant increase mrna expression isoforms extra short although expressed significantly lower levels western blotting predominantly detected anti apoptotic isoform immunofluorescence showed staining discrete nuclear foci transfection pre mir anti mir resulted significant increase decrease respectively foci fibroblasts treated inflammatory cytokines upstream increased total mass positive foci furthermore transfection intestinal fibroblasts pre mir resulted increase mrna protein levels finally immunohistochemistry showed reduced protein expression fibrotic samples compared non controls together findings suggest induction direct regulation mir via utr propose anti fibrotic mir axis influence intestinal fibrosis future therapeutic modulation pathway contribute management fibrosis
introduction lipid sensing activating receptor microglia known important alzheimers disease whether plays beneficial detrimental role disease pathogenesis controversial methods analyzed risk variants genetics initiative study sequencing project compared variants risk functional impact reporter assay finally analyzed expression human monocytes results provide evidence increased risk associated several variants show variants decreased markedly increased binding ligands identify hdl ldl novel ligands also show expression human monocytes minimal compared monocyte derived dendritic cells discussion results suggest signaling helps protect cause harm excess supporting idea proper function important counteract disease progression alzheimers association published elsevier inc rights reserved
objective although cognitive behavioral therapy cbt represents first line evidence based psychotherapy bulimia nervosa individuals seeking treatment access specialized intervention compared internet based version cbt group therapy conducted via therapeutic group treatment conducted via traditional face face group therapy method two site randomized controlled trial tested hypothesis inferior total adult patients males received sessions group cbt weeks either outcomes compared end treatment month follow results end treatment inferior producing abstinence binge eating however month follow mostly inferior participants condition continued reduce binge eating frequency end treatment month follow conclusions cbt delivered online group format appears efficacious treatment although trajectory recovery slower face face group therapy online groups increase accessibility treatment represent cost effective approach service delivery however barriers service delivery state specific license ethical guidelines online therapists need addressed karger basel
box plays imperative role designing strong block cipher designing box based chaos attracted lots distinct characteristics relevant cryptography paper system investigated sophisticated nonlinear behaviors used generate two bit integer sequences drive iterative two position identical map according indicator typical evaluation criteria including nonlinearity differential uniformity strict criterion output bits independence criterion property preferred box obtained batch generated ones comparison state art chaos based schemes shows obtained box achieves better performance
interaction simulations particles structures often performed context combined discrete finite element fem method efficient robust accurate contact algorithm challenging contact problems essential three dimensional discrete finite element contact algorithm named proposed research group contact algorithm discrete finite element contact problems based penalty function method despite quite established algorithm lack efficiency robustness accuracy certain situations special mesh pattern applied however since cases readily appear practice engineering application algorithm named developed resolve issues thus significantly applicable challenging contact problems proposed algorithm includes improved global phase directly find potential segments rather nearest node discrete elements contact counterparts furthermore memory cost time consumption algorithm linear algorithm readily extend parallel computing several numerical examples demonstrate achievable improvements terms efficiency robustness accuracy contact analysis validate capability algorithm granular science mechanical engineering elsevier rights reserved
attracted attention recent years help companies data collect large amounts data efficiently system sensing tasks divided many small sub tasks easily accomplished smartphone users companies take advantage data collected smartphone users improve quality services efficient task assignment mechanism design critical realistic constraints however existing studies task assignment issue still many limitations failed consider time budget smartphone users therefore work studies optimal task assignment problem systems maximize task completion rate consideration time budget users also prove optimal task assignment problem hard thus adopt linear relaxation greedy techniques design near optimal task assignment mechanism also empirically evaluate mechanism show proposed task assignment mechanism efficient
system software engineering development changes occurring process almost inevitable often poorly managed due lack efficient mechanisms spontaneously handling run time changes proposed change aware process management system allows process actors reporting emergent changes analyzing possible impacts people affected changes end integrated change management component process management system process management system monitors process uses run time process information construct process dependency graph representing dependencies among elements running processes change management component captures change requests sent reasons determine impacted elements reflects information process instances therefore uncover intra process inter processes dependencies process models implemented prototype named based platform graph database copyright john wiley sons ltd
non alcoholic fatty liver disease associated obesity insulin resistance type diabetes cardiovascular disease considered hepatic manifestation metabolic syndrome represents spectrum disease relatively benign simple serious non alcoholic progress liver cirrhosis hepatocellular carcinoma end stage liver failure liver transplantation although increasing prevalence developed countries substantial implications public health many precise mechanisms accounting development progression unclear environment early life important determinant cardiovascular disease risk later life studies suggest also extends review data animal models human studies suggest fetal early life exposure maternal excess glucocorticoids environmental pollutants confer increased susceptibility development progression offspring effects sex specific also consider studies aimed identifying potential dietary pharmacological interventions aimed reducing risk suggest human epidemiological studies needed ensure data animal models relevant human health
purpose assessed lower urinary tract symptoms clinical outcomes diabetes mellitus patients non diabetic non patients receiving resection prostate methods analysis retrospective cohort study using years claims data national health insurance research database total patients persistent underwent prostate enlargement benign prostate enlargement enrolled divided two groups non groups patients characteristics postoperative clinical outcomes medication records compared chi square test used categorical variables independent samples test continuous variables multivariable logistic regression analysis used compare risk postoperative outcomes finally estimated medication free survival rate using kaplan meier method compared study groups using log rank test results group patients higher prevalence comorbidities postoperatively group lower rates urinary tract infection odds ratio higher rates urinary retention requiring within month higher proportion patients took anti within first months blockers months receiving overall group patients worse postoperative survival compared non group patients confidence interval conclusion patients require higher rates continuing medication especially anti months postoperatively alpha blocker months postoperatively patients also higher incidence urine retention surgery patients relatively poor treatment outcomes compared free patients
cell tracking plays crucial role biomedical computer vision areas cells generally frequent deformation activities small sizes microscope image tracking non rigid non significant cells quite difficult practice traditional visual tracking methods good performances tracking rigid significant visual objects however suitable cell tracking problem paper novel cell tracking method proposed using convolutional neural networks multi task learning techniques learn robust cell features improves generalization performance tracking proposed cell tracking method consists particle filter motion model multi task learning observation model optimized model update strategy training procedure cell tracking divided online tracking task accompanying classification task using technique observation model trained building cnn learn robust cell features tracking procedure started assigning cell position first frame microscope image sequence particle filter model applied produce set candidate boxes subsequent frames trained observation model provides confidence probabilities corresponding candidates candidate highest probability final prediction finally optimized model update strategy proposed enable multi task observation model variation tracked cell entire tracking procedure performance robustness proposed method analyzed comparing commonly used methods experimental results demonstrate proposed method good performance cell tracking problem elsevier rights reserved
familial cancer predisposition syndrome causes early onset associated increased risk currently lack consensus order coli gene testing implement surveillance online questionnaire completed genetic capture current practices regarding questions findings associated likely prompt testing otherwise asymptomatic year old child negative family history multiple tumors congenital hypertrophy retinal epithelium screening majority recommend children less age five years known mutations interval every months commonly suggested however responses extended screening less annual basis results highlight need investigation genetic recommend testing young risk children factors influence views ideal age indication testing studies issues help define best clinical practice model genetic testing screening pediatric patients
study wear mechanisms nanocomposites produced mechanical milling cold studied wear maps showed maximum amount wear region milling times observed samples also maps show wear region mechanical milling maximized milling time samples milling time weight loss decreases increasing sliding speed normal loads also wear mechanism observed conditions samples show increased resistance crack initiation wear test
background heterozygous mutations thyroid hormone receptor alpha gene cause resistance thyroid hormone alpha disease characterized variable manifestations untreated congenital hypothyroidism raised triiodothyronine thyroxine ratio normal thyrotropin levels recently described zebrafish embryos expressing dominant negative form key features zebrafish human receptors functionally methods study expressed several human thyroid hormone receptor alpha variants zebrafish embryos analyzed resulting phenotypes results injected embryos showed variable defects including cerebral cardiac edema likely caused aberrant heart development anemia incomplete formation vascular network moreover injected embryos presented severe defects development thus affecting autonomous feeding swimming behaviors surprisingly expression mutants detectable effect thyrotropin beta thyrotropin releasing hormone transcripts indicating action limited thyroid hormone reception beta targets hypothalamic pituitary level vivo previously described vitro treatment high triiodothyronine doses efficiently observed defects embryos injected missense variants conclusion injection human variants zebrafish embryos causes tissue specific defects clinical biochemical manifestations described manipulation zebrafish embryos represents novel vivo model screen functional consequences variants rescue potential new therapeutic compounds
hyperspectral raman images human prostatic cells collected analysed several approaches reveal differences among normal tumor cell lines objective study test potential different methods providing diagnostic responses focused analysis region owing optimal signal noise ratio main differences spectra two cell lines observed frequency range multivariate analysis identified two principal components positively recognized due protein lipid fractions respectively tumor cells exhibited modified distribution lipid fraction mainly localized alongside cell boundary result useful preliminary screening principal component analysis found provide high contrast suited image processing purposes self modelling curve resolution made available meaningful spectra relative concentration values revealed increase lipid fraction tumor cell respect control finally univariate approach confirmed significant reproducible differences normal tumor cells elsevier rights reserved
study explore blood material interactions impacted rendering clinical quality medical mechanical heart valve aim reducing complications associated basic cell adhesion evaluated assess blood material interactions hemodynamic performance analyzed without coating results show coating contact angle degrees strikingly eliminates platelet leukocyte adhesion surface alternatively many platelets activate carbon base material show performance index increases coated valve relative valve maximum possible improved performance valves exhibit instantaneous shear stress reynolds shear stress therefore potential requirement antiplatelet anticoagulant drug regimens typically required patients receiving minimizing blood material interactions minimal impact show first time coated surfaces promising direction minimize thrombotic complications complex devices heart valves
victims violence need special treatment emergency room including exact documentation stand court happen documentation made clinician forensic site aim review provide clinicians guide documenting information victims violence identify potential victims violence presentation selected typical cases discussion basic literature expert opinions victims violence present variety injury patterns attending physician recognize result violence urgent care needed forensic available documentation made clinician particular importance attached exact photo documentation description injuries commonly physicians nurses adequately trained dealing situations continuing education field wound documentation words pictures necessary order provide proper documentation cooperation clinicians forensic medicine specialists intensified
vibration energy harvesting converts mechanical energy ambient sources electricity power remote sensors compared linear poor performance away natural frequency nonlinear vibration energy perform better use vibration energy broader spectrum present hybrid nonlinear energy combines stability internal resonance increase frequency bandwidth two fold increase frequency bandwidth obtained compared stable system fixed magnets consists piezoelectric cantilever beam carrying magnet facing fixed magnet spring allows magnet move along beam provides extra stored energy increase amplitude vibration acting mechanical amplifier coupled mathematical model system presented obtain dynamic response cantilever beam magnet output voltage perturbation method multiple scales applied solve equations obtain approximate analytical solutions effects various system parameters frequency responses investigated numerical approaches long time integration method technique used verify analytical results results study used improve efficiency converting mechanical vibration useful electrical energy frequency bandwidth elsevier ltd rights reserved
surface remote sensing properties provides ground truth satellite model validation important component observation system due different characteristics background variability information obtained different locations usually different spatial implying location carefully chosen measurement extended greater area study present objective observation array design technique automatically determines optimal locations highest spatial based ensemble kalman filter theory ensemble constructed using optical depth products five satellite sensors optimal locations solved sequentially minimizing total analysis error variance means observations locations reduce background error variance largest extent location determined algorithm verified larger spatial arbitrary location addition existing active robotic network sites selected optimal locations mostly concentrated regions high spatial namely south africa east asia north pacific islands places focuses establishing future sites order reduce uncertainty monthly mean observations locations contribute approximately total background uncertainty reduction
background children disabilities often target prejudice peers effects prejudice include harmful health consequences contact hypothesis previously shown promote positive attitudes towards range social groups objective conduct systematic review meta analysis effectiveness school based interventions improving childrens attitudes towards disability contact people disabilities methods comprehensive search conducted across multiple databases studies included evaluated intervention aimed improve childrens attitudes towards disability involved either direct person indirect extended contact people disabilities data meta analysis results twelve studies met inclusion criteria found significant effects six used direct contact two used extended contact two used media based contact one used guided contact one contact intervention found significant effects three meta analyses showed direct contact extended contact improved childrens attitudes evidence contact conclusions direct extended guided contact interventions effective improving childrens attitudes towards disability evidence contact elsevier inc rights reserved
findings extensive literature survey focusing bridge structural health monitoring shm presented conventional emerging technologies reviewed deployment considerations new shm lack published calibration studies quantification uncertainty studies new sensors highlighted major concern area future research currently examples shm systems clearly provided significant value owners monitored structures results literature survey used propose categorization system better assess potential outcomes bridge shm shown shm studies categorized one combination following anomaly detection sensor deployment studies model validation threshold check damage detection new framework aids engineers specifying monitoring systems determine measured hence allowing better evaluate value delivered relevant stakeholders monitoring investments
mutations connection terminal reverse transcriptase domains hiv shown impact drug resistance inhibitors however impact context non subtypes poorly assessed study aimed characterize resistance related mutations terminal portions treatment failing patients southern brazil region endemic hiv subtype hiv viral rna isolated reverse transcribed infected subjects genomic regions analyzed polymerase chain reaction dna sequencing phylogenetic analysis two novel mutations evidenced brazilian hiv strains treatment failing patients global viral isolates subjects treatment selected hiv selected hiv subtype hiv terminal mutations described hiv also occur hiv work novel mutations display subtype specific predominance occurrence
assessments linguistic ability amongst inner city african american children cross cultural assessments problem solving skills amongst participants without formal education several contexts around world demonstrated need investigators distinguish possible existence form competency matter whether evidence competency elicited particular assessment tool previously mentioned cases evidence suggests participants competencies question failed demonstrate least partially result nature assessment context current article takes need culturally sensitive assessment point argues today development competence understood necessary benefits idea culturally sensitive assessment still relies problematic characterization competencies discrete sets stable underlying current research dynamic systems perspective psychology suggests intelligent human action involves contextual self organized emergence adaptive behavioral solutions rather expression latent competencies adequate conceptualization competence therefore account emergence rather competencies hidden latent behavioral performances
purpose although previous research established moral emotion moral judgment moral identity influence consumer intention engage prosocial behavior circumstances factors reality concurrently influence judgment process therefore important get nuanced understanding combinations factor lead high intention engage prosocial behavior paper aims discuss issues design methodology approach research employs fuzzy set qualitative comparative analysis explore different configurations moral emotion judgment identity lead high consumer intention engage prosocial behavior findings findings indicate four configurations moral emotion moral judgment moral identity lead high intention engage prosocial behavior research limitations implications research focuses case hospital thus important findings nonetheless methodological opportunity emerges broaden examinations service cultural contexts practical implications findings research help hospital develop effective combinations marketing strategies promote prosocial behavior among customers originality value paper provides first empirical evidence existence multiple pathways moral emotion judgment identity lead high consumer intention engage prosocial behavior implications research also highlight importance cultural context understanding consumer behavior
background cotton spp worlds utilized textile fibre source important economically valuable crop worldwide understanding genomic variation cotton species important exploitation excellent characteristics wild cotton improving diversity cotton breeding however discovery dna polymorphisms cotton genomes lagged behind important crops results total reads specific length amplified fragment tags dna polymorphisms identified using specific length amplified fragment sequencing seq including snps reference genome five cotton species gene ontology enrichment analysis revealed number significant terms related reproduction acc based new data sets reconstructed phylogenetic trees showed high concordance phylogeny large amount genetic variations identified validated single strand conformation polymorphism method applied genetics breeding receptor species donors conclusions using seq large number dna polymorphisms identified comprehensive analysis dna polymorphisms provided insights different cotton species importantly identification numerous genetic variations provides basis practical future breeding results presented herein provide valuable genomic resource new insights genetics breeding cotton
novel dynamic radio cooperation strategy proposed cloud radio access network cloud consisting multiple remote radio heads connected central virtual base station pool particular key capabilities cloud computing resource sharing real time communication among design joint dynamic radio clustering cooperative scheme maximizes weighted sum rate system utility due combinatorial nature radio clustering process non cooperative design underlying optimization problem hard extremely difficult solve large network proposed approach aims suboptimal solution transforming original problem mixed integer second order cone program applying sequential convex approximation derive novel iterative algorithm numerical simulation results show low complexity algorithm provides near optimal performance terms significantly conventional radio clustering schemes additionally results also demonstrate significant improvement computing resource utilization cloud traditional distributed computing resources
paper assesses different levels geographical wind photovoltaic energy resources affect outcomes energy system model energy system models used policy making typically high technology detail little spatial detail however generation potential integration costs variable renewable energy sources time profile production depend geographic characteristics infrastructure place case study generate spatially highly resolved synthetic time series potential production locations wind power regional differences costs wind turbines however smaller cost reductions induced technological learning one modelled decade wind availability shows significant regional differences mainly differences summer days winter important solar availability homogenous introduce wind data energy system model times different levels regional results show point maximum potential reached wind regions significantly affects results causing lower electricity generation wind authors published elsevier ltd
conflicting evidence regarding long term effects unilateral cardiovascular diseases excessive increase blood pressure exercise called hypertensive response exercise sign hypertension increased cardiovascular risk decrease glomerular filtration rate patients unilateral associated disturbance circadian changes without affecting absolute levels aimed investigate circadian changes hypertensive response exercise patients preserved renal functions undergone unilateral causes rather organ donation study enrolled patients mean age years male unilateral healthy controls mean age years male patients undergone office ambulatory measurements stress test median time since years patient group median patient group lower controls without significance respectively significant difference groups terms office measurements night time diastolic systolic mean arterial pressure map night day time ratio map ambulatory measurements results stress tests hypertensive response exercise ratios also similar groups study revealed increase long term cardiovascular risks one decade unilateral based circadian changes hypertensive response exercise patients
immigration exemplify reach immigration law enforcement lives latino community members yet little research characterizes health effects examined health implications immigration resulted multiple occurred community survey latino population used linear regression following principal axis examine influence timing immigration enforcement stress self rated health controlled age sex relationship status years county occurred children home participants completed survey completing survey associated higher levels immigration enforcement stress lower self rated health scores findings indicate negative impact immigration latino communities immigration discussions include holistic assessments health
background bipolar disorder costs english economy estimated year largely incomplete recovery analysis estimated cost effectiveness group versus group peer support treating methods week pragmatic randomised controlled trial rct conducted primary care primary analysis compared using multiple datasets missing values economic model used compare treatment usual tau perspective health personal social services results participants receiving used costly health related resources net cost per person quality adjusted life year gain cost per gained cost effective versus decision makers willing pay least per gained costs avoid one relapse economic model indicates cost effective versus tau reduces probability relapse reduces probability increases time relapse limitations participants generally inconsistent attending treatment sessions low numbers complete cost data factors contributing pervasive uncertainty results discussed conclusions first economic evaluation versus pragmatic trial associated modest improvement health status higher costs high level uncertainty data results
impact procedure lower urinary tract symptoms luts remains unclear aim evaluate effects procedure urodynamic stress incontinence consecutive women prospectively underwent procedure urodynamic studies pad testing luts sexual function questionnaires assessed treatment thirty five women underwent procedure among women baseline pad weights objectively cured improved among women mild baseline pad weight nine cured five improved among ten women baseline pad weight two cured six improved among women complete questionnaire data months seven cured four improved regarding luts majority domains health questionnaire female sexual desire function exhibited significant improvements forty percent partners patients felt sexual function improved months nonetheless urodynamic values differ across effect procedure mild moderate month follow effective pad weight moreover improved luts quality life qol sexual function partners studies performed assess long term sustained efficacy
human chondrocytes characterized phenotype lack ability restoring inherent functions investigated whether supplemented mechanical signal via compression loading affect phenotype specifically applied cyclic compression loading cultured collagen constructs measured expression major factors cell matrix interaction molecules matrix degradation enzymes dynamic compression loading stimulates expression nuclear localization reduces events via downregulated expression results contribute better understanding towards elsevier inc rights reserved
iron essential nutrient acting catalyst metabolic reactions fundamental cell survival proliferation iron delivered metabolism via surface receptor found transformed cells murine deficient cell lymphoma model cell acute lymphoblastic leukemia lymphoma cell lines consequence cells developed addiction toward iron whose dramatically affected survival induce apoptosis interestingly displayed synergistic activity three specific drugs dexamethasone doxorubicin appeared act reactive oxygen species dependent dna damage response potentiated action inhibitor pathway dna repair results demonstrate targeting iron metabolism interesting adjuvant therapy acute lymphoblastic leukemia
model updating using measured system dynamic response wide range applications system response evaluation control health monitoring reliability risk assessment paper interested model updating linear dynamic system non classical damping based incomplete modal data including modal frequencies damping ratios partial complex mode shapes dominant modes proposed algorithm identification model based linear structural model mass stiffness matrix represented linear sum contribution corresponding mass stiffness matrices individual prescribed damping matrix represented sum individual case viscous damping terms mass stiffness matrices case damping combination former quantify uncertainties model parameters bayesian approach developed new gibbs sampling based algorithm proposed allows efficient update probability distribution model parameters addition model parameters probability distribution complete mode shapes also updated convergence issues numerical issues arising case high dimensionality problem addressed solutions tackle problems proposed effectiveness efficiency proposed method illustrated numerical examples complex modes published elsevier ltd
paper present result regarding probability distribution coefficients extends theorem presented previous work design experiments statistical process control using analysis control engineering practice include new control chart called orthogonal proposed order detect mean change process statistic proposed control chart based weighted coefficients performance study shows control chart performs slightly better optimal version control chart ifac international automatic control hosting elsevier ltd rights reserved
todays industrial environment common see use pipes vessels transfer mixtures materials products along however measurement amount delivered done one way isolate components first meter measure volume individual component measuring procedure often production rate work implements noninvasive real time monitoring system measure flow concentration velocity distributions two phase liquid gas flow system uses combination specially designed twin plane segmented electrical capacitance tomography sensor portable electrodes cross correlation method velocity measurement technique measured values data sensor manipulated reconstruct cross sectional image pipeline computer programming images cross correlated obtain velocity profile multiphase flow visualization results deliver information regarding flow regime superficial velocity concentration distribution two phase flow rate measurement system information obtained able improve process design verification existing computational modeling simulation techniques technique possibility promote excellent opportunity build methods measuring velocity field multiphase flow using noninvasive technique cross correlating
background coronary heart disease chd important complication atherosclerosis biomarkers associate chd development potential predict chd risk determine whether genes showing altered expression coronary heart disease chd patients compared controls chd risk biomarkers methods control chd groups represented atherosclerosis chd development gene profiling investigated peripheral blood mononuclear cells using dna microarrays eight selected genes expressed chd groups validated real time quantitative reverse transcription pcr plasma protein determination results pro platelet basic protein beta hemoglobin mrna expression significantly increased chd groups compared controls plasma proteins correspondingly increased conclusion potential chd biomarkers patients
background various studies experimentally ice cream headache headache attributed ingestion inhalation cold stimulus using different protocols aim study compare two protocols methods ice fast ingestion ice water used provoke clinical features compared results ice water stimulus significantly often ice stimulus ice water significantly shorter latency median range median range difference pain character ice stimulation predominantly described pressing ice water stimulation second followed headaches ice water occurred significantly often volunteers without discussion ice water frequent shorter latency different pain character higher pain intensity ice finding two subsequent attacks volunteers supports notion two types exist indicates involvement trigeminal autonomic reflex
objectives evaluate efficacy adverse events flexibly adding patients overactive bladder oab refractory monotherapy first antagonist methods total patients refractory oab enrolled prospective open label protocol inclusion criteria persistent symptoms partial response month behavioral therapy optimized dose one antimuscarinic agent baseline weeks day flexibly added assessed oab symptom indexes patient perception bladder condition post void residual along therapeutic effect tolerability patients continuing combined antimuscarinic therapy followed results compared baseline oab symptom indexes significantly decreased visits total patients reported successful therapeutic effect weeks respectively twenty four patients discontinued therapy weeks respectively patients continued combined medication discontinuation combined medication noted patients due due lack efficacy conclusions flexibly adding second antimuscarinic agent effective safe oab patients first antimuscarinic treatment short term period patients dropout rate high long term efficacy combination two antimuscarinic agents limited
chemical cross linking high molecular weight two main causes resistance however particles microorganisms purposes study dry technical potassium containing monomers geotextile incubated soil water absorbing highest number soil bacteria utilized sole carbon energy source found first month incubation soil equal log cfu water absorbed decreased log units within next months time initial water holding capacity decreased moreover dry mass declined two bacteria bacillus isolated found able pure cultures technical day growth mineral salt medium activity equal protein respectively also able degrade ultra pure synthetic root medium day growth respectively
global manufacturing companies implement manufacturing engineering proper consideration given manufacturing process resources appropriate manufacturing site particularly effective enterprise resource planning erp system implementation global manufacturing environment product data management integration product data one important keys success product data integration engineering materials needs transformed manufacturing materials transformation done way fit manufacturing site process methodology appropriate integration transformation required paper proposes digital manufacturing key tool data integration erp digital manufacturing technology possessing physical logical computer modeling simulation technique actual manufacturing provides methodology transforming fits manufacturing site based process resource models reflect manufacturing site also provides methodology verification process resource model integration using method process resource data verified appropriate manufacturing site sent erp system
paper improved particle swarm optimization method based standard particle swarm optimization pso changing range genetic algorithm proposed applied form finding analysis suspension bridge installation new method integrated successive iteration method form finding analysis transfers usual iterative process form finding analysis single objective optimization problem computation formulation computer code developed implemented benchmark examples studied test performance method numerical experiments results show used viable solution methodology form finding analysis various initial boundary complicated load conditions overcome limitations conventional newton iterative method furthermore compared pso pso greater accuracy efficiency finally method applied actual form finding analysis suspension bridge yangtze river bridge validate practicality feasibility based method engineering design case study indicates provides superior convergent solutions analysis considered compared method computation time affordable large scale engineering bridge construction design analysis
finite element model cable stayed bridge established based ansys dynamic characteristics bridge analyzed using subspace iteration method based recorded wind data measured spectra expression presented using nonlinear least squares regression method turbulent bridge site simulated based spectral representation method fft technique influence key structural parameters measures dynamic characteristics bridge investigated parameters include dead load intensity vertical lateral torsional stiffness steel box girder addition influence elastic stiffness connection device employed towers girder vibration mode steel box girder investigated analysis shows vertical lateral torsional displacement responses reduce gradually dead load intensity increases dynamic characteristics structural displacement response slightly affected vertical torsional stiffness steel box girder lateral torsional displacement responses reduce gradually lateral stiffness increases results provide reference dynamic analysis design super long span cable stayed bridges
background aim study determine whether polymorphisms toll like receptor confer susceptibility rheumatoid arthritis juvenile idiopathic arthritis central south chinese han population methods genotyping six studied polymorphisms gene conducted unrelated patients healthy control subjects unrelated patients healthy control subjects using direct sequencing technique comparisons cases controls alleles genotypes haplotypes carried using fishers exact test results significant genetic associations detected addition found significantly associated susceptibility furthermore significant increasing distributions haplotypes also found moreover frequency significantly increased positive anti positive subjects anti anti conclusions study suggested contribute contribute pathogenesis central south chinese han population
paper describes use domain decomposition methods accelerating wave physics simulation numerical wave based methods provide accurate simulation geometrical methods higher computation cost context virtual reality quality results estimated according human perception makes geometrical methods interesting approach achieving real time physically based rendering investigate geometrical method based beams rays tracing enhance two levels parallel processing techniques domain decomposition methods coupled classical parallel computing shared distributed memory optic acoustic evaluate acceleration impact domain decomposition scheme speedup measurements clearly show efficiency using domain decomposition methods real time simulation wave physics copyright john wiley sons ltd
article provides overview digital video satellite specifications context extension mobility different ways receiving digital television mobile devices summarized overall antenna signal processing presented attention paid analog channel selection frequency noise issues deeply developed paper finally new technique technique improving noise performances suggested claimed requirements extend fixed reception toward mobility band large area coverage good quality received signals reduced total network cost low power consumption thanks full analog signal processing channel selection
bacterial regulatory small rnas play important roles gene regulation frequently connected expression virulence factors diverse bacteria described pathogens depth analysis described causative agent porcine responsible considerable losses industry search developed strategy computational analysis bacterial genome using four algorithms different approaches followed experimental validation coding strand expression rna candidates confirmed northern blotting pcr rna sequencing among two likely three regulatory rnas two widely studied putative novel trans acting never described bacteria latter group several potential mrna targets many involved virulence stress resistance metabolism connect complex gene regulatory network identified conserved among evolutionarily closer share host results show combination newly developed computational programs successfully utilized discovery novel indicate intricate system gene regulation thus providing clues novel aspects virulence explored studies
background prevalence drug resistant tuberculosis higher regions china beijing lineage mycobacterium tuberculosis dominant strain however information multidrug resistant extensively drug resistant particularly correlation beijing lineage correlation drug resistance beijing strains limited material methods conducted prospective study describe prevalence beijing lineage strains china underwent drug susceptibility testing first second line anti tuberculosis drugs beijing lineages detected large sequence polymorphisms polymerase chain reaction results total clinical isolates identified overall percentage cases respectively overall beijing lineage patients non beijing lineage patients beijing lineages isolates isolates isolates isolates none isolates detected significant differences beijing non beijing strains observed regarding inh resistance respectively conclusions prevalence remains high imposes challenges control four beijing isolates observed correlation beijing lineage correlation drug resistance beijing strains surveillance clinical isolates recommended strengthen identification beijing strains
examined women aged years mean age years secondary frequent years repeatedly unsuccessful treated overactive bladder chronic rare cause sustained disorders young female patients reproductive age established development secondary caused weight loss cosmetic subsequent deficit atrophy morphological examination bladder mucosa important diagnosis helps identify true cause atrophy bladder mucosa secondary cosmetic determine future course treatment sustained young women treatment often effective case proper timely diagnosis absence irreversible changes
inverted pendulum classical control problem unstable system characteristics higher order unstable multivariable nonlinear strong coupling varieties methods applied control inverted pendulum system pid control optimal control robust control sliding mode control fuzzy control neural network control human intelligent control paper firstly using principle newtonian mechanics mathematical model inverted pendulum system established differential equations state space representation derived secondly controller designed using linear quadratic regulator cost equation pid controller designed tuning pid parameters focused finally simulation results show inverted pendulum balanced controllers
background increasing need exists suitable measures evaluate treatment outcome adolescents core pan theoretical brief questionnaire developed purpose lacks studies different cultures explore acceptability factor structure reliability validity sensitivity change finnish translation study conducted department adolescent psychiatry university central hospital finnish translation prepared team professionals adolescents clinical sample patients asked complete form together bdi filled forms month treatment analysis included acceptability confirmatory factor analysis internal test test reliability concurrent validity influence gender age criteria reliable core accepted rate missing values low internal consistency test test reliability good results supported one factor model core showed good concurrent validity two widely used symptom specific measures gender moderately strong effect scores effect age evident measure sensitive change showing larger effect size bdi conclusions results show translation core finnish successful core good psychometric properties measure taken wider use clinical settings outcome measurement adolescents
resources environmental issues increasingly becoming focus global global economy moving industrial agricultural economy tertiary industry service economy modern services include consumer services services modern industry one major services development depend appropriate professionals building professionals adaptation producing services imperative trend producing services global economy need review modify enrich perfect management professional training scheme teaching course system article first concept producing services relationship services discusses construction teachers team construction practical teaching system perspective curriculum system thereby builds management subject construction scheme private colleges modern service industry development trend
paper proposes new operation control strategy power assisted using one brushless motor conventional electrical heavy large one person move two electric motor wheels hand proposed system small volume easy move due presence single wheel motor unlike conventional electric structure control reduce weight volume control without special control system algorithm needed proper operation proposed system uses one sensor detect acceleration direction movement using sensor speed control achieved speed control system three kinds operations done speed increment speed external force speed external force emergency breaking evaluating time duration external force validity proposed algorithm verified experimental results
objective owing rapid increase clinical need aimed implement review performance model germline genetic testing eligible women high grade non epithelial ovarian cancer via genetic embedded gynecology oncology clinic methods model implemented involved specialized referral form weekly genetics lead multidisciplinary review referrals pre post test genetic counseling provided embedded genetic chemotherapy time performance outcomes retrospectively following two consecutive one year periods including survey data medical specialist comfort model results sixty four women underwent testing two year post implementation period rate detection pathogenic variants referral rate eligible women significantly increased patients receiving results first line chemotherapy genetic counseling time decreased min cancer specialists comfortable model conclusions model proved effective increasing uptake genetic testing eligible patients efficient patients genetic cancer specialists acceptable cancer specialists facilitated location genetic oncology service delivery separation clinical responsibility genetic testing specialist genetics service ensuring accurate robust patient centred care elsevier inc rights reserved
like neurodegenerative diseases alzheimer disease prominent inflammatory component mediated brain microglia reducing microglial inflammation potentially least slow neurodegenerative process major challenge development treatments targeting brain inflammation complexity molecular mechanisms determine whether microglia become inflammatory take neuroprotective phenotype process highly multifactorial raising possibility multi target multi drug strategy effective conventional monotherapy study takes computational approach finding combinations approved drugs potentially effective single drugs reducing microglial inflammation novel approach exploits distinct advantages two different computer programming languages one imperative declarative existing programs written languages implement model microglial behavior input output relationships programs agree data microglia extensive test battery imperative program used efficiently screen model efficacious combinations drugs declarative program used analyze detail mechanisms action efficacious combinations possible drug combinations simulated screen identifies able move simulated microglia least way neuroprotective phenotype subsequent analysis shows efficacious combinations stand superior strength reliability model offers many experimentally therapeutically relevant predictions concerning effective drug combinations mechanisms action
receptor activation acid demonstrated inhibit inflammation fibrosis development liver kidney intestine multiple disease models activation also demonstrated suppress inflammatory response promote lung repair lung injury study investigated protective effects treatment day inflammation tissue remodeling fibrosis bleomycin induced pulmonary fibrosis rat model effects treatment morphological molecular alterations lung remodeling right ventricle also evaluated lung function assessed measuring airway resistance acute phase days bleomycin promoted initial thickening fibrosis lung upregulation genes related epithelial proliferation tissue remodeling hypoxia days evident increase deposition collagen lungs observed excessive deposition accompanied upregulation transcripts related extracellular matrix tgf indicating lung fibrosis administration protected bleomycin induced lung damage suppressing molecular mechanisms related epithelial transition emt inflammation collagen deposition dose dependent reduction proinflammatory cytokines tgf expression recently approved treatment idiopathic pulmonary fibrosis ipf significantly bleomycin induced pro fibrotic genes expression exert significant effects beta treatment bleomycin challenged rats also improved pulmonary function effectively airway resistance lung stiffness vivo results similar even superior obtained conclusion results suggest important protective effect bleomycin induced lung fibrosis critical mediators pathogenesis ipf elsevier ltd rights reserved
causes complex poorly understood paper describes homeless population county california terms adverse childhood events traumatic brain injuries family breakdown respondents reported severely traumatic grew household person drug alcohol dependence psychological abuse child seventy six percent subjects recalled least one tbi loss consciousness nineteen percent foster care children reported someone parent primary caregiver fifty three percent felt moved much children experienced children county highest median income highest rate nation leaders community members work together improve lives homeless prevent another generation homeless people
novel insensitive switched capacitor filters presented state space representation provides means implementing orthogonal filter structures good sensitivity properties state space represented regular signal flow graph switched capacitor basic sections signal flow graph proposed four phase implementation provides insensitive switched capacitor design example illustrates application novel approach
background intentional relationship model specifically focused relational aspect therapy model describes six therapeutic modes represent different types interaction therapist however preferences therapeutic mode use researched aims study aims describe preferences therapeutic modes undergraduate occupational therapy students explore factors associated therapeutic modes methods sample occupational therapy students based two different norwegian universities participated study completed norwegian self assessment modes questionnaire along sociodemographic information descriptive analysis bivariate correlation linear regression analysis employed results problem solving mode frequently endorsed generally weak associations variables female sex student education program associated higher preference collaboration conclusion diversity students preferences modes problem solving mode preferred students need aware mode feel comfortable make use modes fit specific occupational therapy education programs need incorporate raising awareness therapeutic modes
activity dependent changes synapses rely functional changes resident proteins gene expression addressed relationship synapse activity expression synaptic genes comparing rna levels normal mice versus secretion deficient therefore silent mammalian locomotion null mutants using microarray expression analysis real time quantitative pcr northern blotting hypothesized genes control synaptic activity differentially expressed mutants controls found synaptic genes differentially expressed however neuropeptide genes detectable expression microarray differentially expressed expressed fold higher control cortex several secreted proteins also differentially expressed genes encoding receptors many synaptic components differential expression confirmed real time quantitative pcr analysis situ hybridization indicated difference neuropeptide expression uniform due loss specific cells mutant primary sensory neurons depend synaptic activity input differential expression observed data argue general relationship activity synapses expression resident proteins suggest link secretion expression genes encoding secreted products
ability rapidly detect characterize drug metabolites biological fluids often relies combination high quality chromatographic separation sensitive high resolution mass spectrometry performance two high throughput approaches namely columns sub particle ultra performance liquid chromatography columns compared detection identification human metabolites urine system produced approximately three times sensitivity detected metabolites monolithic column approach sharp peaks produced seem particularly advantageous coupled mass spectrometry apparently reducing ion suppression leading superior sensitivity hence lower limits detection elsevier rights reserved
art quantum algorithm design highly search algorithm constitutes quantum computational software article use methods geometric algebra information geometry enhance algebraic efficiency geometrical significance digital analog representations algorithm respectively specifically used describe discretized iterative procedure exploits quantum interference amplify probability amplitude target state measuring query register transition digital analog descriptions occurs via theorem relates suitable controls quantum mechanical evolution quantum state towards target state discrete transition completed used interpret iterative procedure path manifold parametric density operators pure quantum states constructed continuous approximation parametric quantum output state algorithm finally discuss nature quantum computing recover quadratic speedup relation identify operation perspective emphasis statistical mechanical considerations elsevier rights reserved
formula car state art hybrid electric vehicle power unit composed gasoline engine two electric motor generator units connected traction system powertrain offers additional degree freedom therefore requires energy management system controller significant influence vehicles fuel consumption achievable time therefore thorough systematic optimization energy management system crucial prerequisite race complexity system strict regulations make time optimal energy management problem non trivial solve effective implementation solution car difficult achieve convex numerical solver designed optimal strategies derived analytically using non smooth version minimum principle respectively building results design nonlinear program tune efficient version optimal control policy order precisely match various boundary conditions fuel consumption battery usage allows simple robust implementation time optimal control strategies vehicle guarantees compatibility rules simulator used test obtained feedforward controls one race results stand comparison optimal solutions obtained numerical solver validate effectiveness strategy ifac international federation automatic control hosting elsevier ltd rights reserved
background aimed compare acceptability levonorgestrel regimen among iranian women based side effects resulting changes amount pattern methods five hundred twenty nine participants aged regular one act unprotected intercourse within included double blind controlled trial randomly assigned lng groups receiving levonorgestrel given apart estradiol plus levonorgestrel repeated respectively results participants receiving levonorgestrel experienced significantly lower side effects case nausea vomiting dizziness significant difference observed efficiencies treatments conclusion significantly lower side effects levonorgestrel considered greater acceptability translated higher efficiency
ion exchange polymer metal composites known type electro active smart material complex mechanism takes nonlinear characteristic blocks development utilization paper new model electro active smart actuator based non integer order models proposed experimental setup realized study electro active smart actuator non integer behavior algorithm based least squares recursive identification developed order identify fractional order model electro active smart actuator fractional order simulation model designed comparing integer order model simulation results demonstrate behavior fractional order model much better integer order model fractional order model electro active smart actuator achieve better performance
flow downward divergent channel turns interesting experimental setup observation upward floating appear view observer detailed analysis flow characteristic parameters necessary better understanding phenomenon boundary layer theory used derive velocity field experimental setup actual flow liquid presence bubble studied experimentally measuring position bubble data statistically processed image analysis observation bubble positions distribution showed reasonable assume flat velocity profile liquid channel tend move boundary layer experiments volume air floating water floating aqueous thus experiment used work suitable reliable determination instantaneous average bubble rising velocities horizontal vertical oscillations institute chemistry academy sciences
present four band polarization insensitive absorber formed four square metallic rings metallic ground plane separated dielectric layer found structure four distinctive absorption bands whose peaks average mechanism four band absorber attributed overlapping four resonance frequencies mechanism absorption investigated distributions electric field particular frequency absorption peak flexibly controlled varying size corresponding metallic ring proposed concept applicable types absorber structures readily scaled structures working microwave frequency range moreover characteristic design used design five band absorber adding one metallic ring proposed absorber potential applications detection imaging stealth technology
protein plays crucial role regulation cellular responses diverse stresses thus major priority cell biology define mechanisms regulate activity response stresses maintain basal levels normal conditions moreover investigation required establish whether rna participates regulating interaction proteins conducting systematic experiments discovered directly binds prevents activation normal conditions upon doxorubicin treatment retained nucleus binding binding levels promotes dependent apoptosis regulation activity results indicate balance regulates activity dependent apoptosis upon doxorubicin treatment indicate change subcellular localization specific circumstances biologically significant
prenatal alcohol exposure lead behavioral cognitive impairments across multiple domains many brain regions impacted prenatal alcohol exposure also linked olfactory processing identification deficits documented certain neurological disorders associated brain regions identification following prenatal alcohol exposure studied compared identification children prenatal exposure alcohol typically developing controls con group hypothesized children group perform poorly children con group san identification test identification test common household children exposed alcohol prenatal development significantly impaired olfactory identification compared typically developing controls findings confirmed hypothesis prenatal exposure alcohol associated identification deficits suggest research warranted identify mechanisms underlying deficits integrity brain areas involved determine whether olfactory performance contribute better identification children risk behavioral cognitive deficits elsevier inc rights reserved
literature data summarized mammals group derivatives substrates mammals studied containing molecule different structure radical showed certain elements action specificity esters derivatives base differences revealed substrate characteristics analysis efficiency performed inhibitors derivatives result managed find quite action depending structure several tested compounds revealed specific inhibitors several mammals
background play important role engineering education influencing instructors pedagogical approaches providing much information students learn research explored students roles played educational experiences students actually use remains largely unexplored purpose phenomenological study describes engineering students use problem solving activities study directly examined students employed order generate detailed descriptions students behaviors approaches reflections regarding actual problem solving experiences method ten senior materials engineering students males females asked think solving engineering problems follow retrospective interviews regarding think session conducted gain depth information students use problem solving activities results students used primarily find information related problem constraints explicitly stated problem furthermore example problems exerted strong influence students problem solving processes students also reported limitations contrasting diversity resources available via internet conclusions study provides insight students use engineering problem solving activities students limited application problem solving suggests serving intended purposes
physical education teachers physically demanding job considerable risk musculoskeletal injuries structurally develop tailored injury prevention programmes teachers clear understanding extent characteristics underlying factors musculoskeletal injuries compared necessary therefore current study prospectively followed teachers non teachers registered musculoskeletal injuries time exposure sports participation one school year pearson tests independent samples tests determined significant differences non teachers regarding demographics variables possibly related injury occurrence teachers non teachers injuries teacher school year difference significantly different adjustment hours spent weekly teaching career injury history preceding six months teachers affected body parts knee back teachers extensive injury history higher work sport index practiced sports taught sports future injury prevention programmes take account great injury history heavy physical load teachers
basal slip dynamic recovery dislocations long assumed main mechanisms accounting sharp magnesium alloys upon dynamic high temperature basal slip allows basal plane mitigate stress axis normal loading direction dynamic recovery allows dislocations maintaining basal plane parallel main loading axis phenomena though pertaining laws plasticity thermodynamics fully explain preferred selection crystal orientation growth dynamically grains example basal plane one two directions either parallel direction also grain boundary relationships established parent grains paper electron diffraction characterization partially microstructures molecular dynamic simulations interfacial defect theory used uncover mechanisms leading phenomena texture formation dynamic simulations show grain boundary energy mobility emerge key governing effects experimentally observed preferred orientation selection growth due low crystal symmetry inherent hexagonal close packed structure magnesium certain grain boundaries possess low interfacial energies high relative boundaries making prime candidates rotation particular new experimentally observed twin boundary associated texture formation simulations theory show twin boundary highly mobile wide dislocation core presumably causing affected grains dominate final texture inc published elsevier ltd rights reserved
experimental studies find strong influence nonverbal signals evaluation political candidates raters asked judge unknown candidates short duration exposures yet viewers exposed candidates verbal nonverbal communication naturally occurring context presence verbal communication make influence nonverbal communication seem attenuated link findings present study uses continuous response measurement uncover relative influence verbal nonverbal communication political opinion formation debate lasting minutes analysis suggests nonverbal communication influences candidate evaluations especially beginning presentation verbal communication seems influential remaining time consistent trend study participants post exposure opinions influenced verbal nonverbal communication
semi empirical approach model temperature effects characteristics carbon field effect transistors proposed model includes two thermal parameters describing behaviour terms saturation drain current threshold voltage whose values extracted simulated trans characteristics device different temperature conditions results compared numerical model online available obtaining characteristics comparable lower cpu calculation time
adenosine binding cassette proteins constitute large family active transporters extracellular intracellular membranes increased drug efflux based adenosine binding cassette protein activity related development cancer cell several articles focused adenosine binding cassette gene expression profiles signatures based expression human adenosine binding cassette genes individual tumor types reported connections established clinicopathological features aim study test theory existence adenosine binding cassette gene expression profiles common multiple types tumors modify tumor progression provide clinically relevant information general adenosine binding cassette profiles constitute new attribute carcinogenesis combined cohort consisted tissues cancer patients breast colorectal pancreatic carcinomas standard protocols rna isolation quantitative real time polymerase chain reaction followed gene expression data individual tumor types merged tumor dataset analyzed bioinformatics tools several general adenosine binding cassette profiles differences gene functions established shown significant relations clinicopathological features tumor size histological grade clinical stage genes among upregulated downregulated ones conclusion results supported theory general adenosine binding cassette gene expression profiles importance cancer clinical research levels presence official symbol among genes key roles profiles supports emerging evidence crucial role various cancers
introduction patients essential thrombocythemia vascular complications contribute morbidity mortality better predict occurrence thrombotic events international prognostic score thrombosis essential thrombocythemia thrombosis recently proposed present application score compare results usual classification system method retrospectively evaluated characteristics risk factors thrombosis patients diagnosis seen last years abc results thrombosis arterial territory prevalent venous sites observed cardiovascular risk factors hypertension diabetes mellitus smoking also risk factors thrombosis age years presence mutation associated occurrence thrombotic events patient classified thrombosis low risk thrombotic event furthermore using thrombosis scale identified two patients thrombotic events follow otherwise classified low risk group traditional classification diagnosis significantly associated arterial thrombosis splenomegaly associated venous thrombotic events conclusion cardiovascular risk factors directly associated arterial thrombosis thrombosis appears better traditional classification identifying lower risk patients need specific therapy
although previous studies reported altered topology brain functional networks patients parkinsons disease modular organization brain functional networks patients remains largely unknown using resting state functional mri fmri graph theory examined modular organization brain functional networks patients early mid motor stage healthy controls compared controls patients tended show decreased integrity segregation within modules inferred significantly increased intra modular characteristic path length within four modules decreased inter modular functional connectivity decreased intra modular clustering patients intra modular characteristic path length within showed significantly positive correlation general cognitive ability group receiver operating characteristic roc analysis revealed highest significant accuracy differentiating patients controls findings provide new insight understanding pathological changes underlie impairment cognition movement parkinsons disease
routinely observe others choices use guide whose choices influence prior work focused effect perceived similarity two individuals self others degree overlap past choices explicitly group real world however dyadic relationship part complex social structure involving multiple social groups directly observable suggest human learners beyond dyadic similarities choice behaviors explicit group infer structure social influence grouping individuals including based choices use groups decide whose choices follow propose computational model idea test model predictions series behavioral experiments experiment reproduce established finding peoples choices likely influenced someone whose past choices similar past choices predicted model dyadic similarity models experiments test set unique predictions model looking cases degree choice overlap individuals choices indicate latent group structure apply model prior empirical results infants understanding others preferences presenting alternative account developmental changes finally discuss model relates classical findings social influence literature theoretical implications model taken together findings demonstrate structure learning powerful framework explaining influence social information decision making variety contexts
background group gastrointestinal parasite humans wide variety animals anaerobic include specific small subunit ribosomal rna subtypes nine found humans variable geographical distribution now study described subtypes present saudi arabia methods total faecal samples collected patients gastrointestinal complaints asymptomatic individuals visiting two major hospitals samples analysed diagnostic pcr microscopy culture methods subtypes isolates determined sequenced tagged site based method results one hundred thirty three positive cases detected diagnostic pcr also positive culture method direct microscopy sensitivities direct microscopy culture method respectively subtype prevalent followed detected study infections significantly predominant among symptomatic patients conclusions knowledge study provides first run information epidemiology city revealing rather moderate prevalence presence three subtypes predominant particularly among symptomatic patients
affective one main features recent studies revealed emotionally affective associated intense feelings emotional instability negative emotions difficulty enduring distress used brain imaging techniques investigate emotion regulation neuropsychological level used situations participants required demonstrate emotional flexibility explore controversy surrounding fact associated cold emotional instability participants performed task emotionally pictures international affective picture system presented different contexts negative positive neutral asked interpret scenario according title according another context created new title negatively labeled pictures shifted positively labeled ones task performance showed increased activation brain regions associated emotion generation example amygdala insula indicates individuals able involved emotionally social situations increased activation temporal regions suggests use semantic perceptual processes construct alternative interpretations situation enhanced memory emotional stimuli furthermore seem possess intense awareness leads shift attention external internal information detect environmental changes cognitive processes enable adjust behavior quickly study supports flexibility hypothesis suggests approach emotion regulation linked rational mode thinking
purpose renal dimensions important assessment tract used evaluate critical aspects renal growth development understanding effect patient position important use interpret parameters prospective study determined effect patient position general body renal length area children undergoing renal ultrasound materials methods october january children underwent renal ultrasound prone bilateral renal length renal area measured pearson statistical analyses used examine correlations measurement bias degree agreement methods results renal length measurements positions complete right left kidneys area measurements complete kidneys children compared individually prone measures renal length area highly correlated pearson analysis greater greater respectively compared method analyses differences means showed greater variance representing wide limits agreement poor neither persistent systematic bias body influenced results conclusions pearson analysis showed high correlation prone renal measurements analysis renal length area demonstrated wide limits agreement allowing use prone measurements renal ultrasound specify standardized positions benchmarks results provide guidance renal ultrasound measurements renal size used indicator kidney health
arrangement proposed four stroke internal combustion engine recover thermal energy products combustion exhaust stroke store energy heat micro channel matrix transfer stored heat compressed fresh charge flows mechanical cycle extra piston locked preferred positions sequence valve events enable lose heat working fluid one interval time gain heat fluid another interval time paper examines whether scheme cylinder regeneration improves cycle thermal efficiency eta models various thermodynamic processes cycle treatments unsteady flow heat transfer inside developed digital simulations cycle made compared engine cycle devoid regeneration provisions seem thermal efficiency compression ratio engine simulated equivalence ratio eta regeneration eta without study shows previous claims efficiency gains via using highly simplified models misleading elsevier ltd rights reserved
introduction epithelial mesenchymal transition emt relates organ fibrosis malignant behavior cancer anti fibrotic agent idiopathic pulmonary fibrosis one functions inhibit fibrotic emt study aimed investigate possibility exert anti tumor effect inhibition emt non small cell lung cancer nsclc cell lines vitro vivo methods nsclc cells used evaluate effects tgf induced phenotypic changes possible tgf signaling pathways modulated evaluated effects emt induced anti cancer drug also analyzed impact tumor growth mice emt change vivo also determined results significantly inhibited tgf induced emt phosphorylation tgf receptor expression also inhibited translocation cytoplasm nucleus induced elevation tgf production cancer cells together induction emt suppressed treatment vivo examination alone inhibit tumor progression whereas combination significantly decreased tumor growth analysis showed suppressed emt change induced conclusions attenuate emt process induced exogenous tgf also tgf produced nsclc cells promising new therapeutic agent treatment nsclc regulation emt elsevier rights reserved
finite element mesh generation major marine controlled source electromagnetic modeling paper present discretization operator automatically converts finite difference model reliable efficient meshes modeling sets background model precisely topography partitioned multiple regions outer regions discretized coarse elements whose maximum size large skin depth regions demonstrate coarse meshes produce accurate solutions numerical dispersion errors meshes accumulate contrast central regions discretized fine elements describe complex detail conductivity distribution mapped meshes volume averaged sense avoid excessive mesh refinement around receivers introduce effective receiver size major advantages summarized follow first automatically generates reliable economic meshes without adaptive interactive cad workflows second produces meshes precisely boundaries topography third derives multiple sets meshes given model mesh optimized different set sources receivers fed subgroup processors parallel computer divide approach improves parallel scalability solution accuracy effectiveness demonstrated various examples
medicinal family reported potential benefit treatment prevention several diseases particular demonstrated protective effects various types cancer several mechanisms present study aimed determine effects phenolic extracts human cell functions particular regard anti proliferative properties three cell types peripheral blood mononuclear cells pbmcs radical scavenging reducing abilities extracts assessed toxicity effects cell cycle distribution apoptosis compounds identified dominance acid extract phenolic ethyl acetate fraction acid methyl total content important first extract acid equivalent compared fraction displayed higher antioxidant activity mmol ethyl acetate showed pronounced effects respectively cells anti proliferative effect associated cell cycle arrest phase population concomitant decrease phases tested extracts displayed addition early apoptotic effects late apoptosis cells obtained data indicate identified least partially responsible observed cytotoxicity
background excessive contributes myriad risk factors chronic diseases multiple reports demonstrated parents influence development childrens behaviors contribute however studies include considerations cultural influences limited methodology considers direct reports young adults parents across cultures exist methods sample young adults parents china recruited completed series questionnaires two cycles correlation multiple regression analyses parents characteristics behaviors parental authority styles examined compared weight related health behaviors young adult children additionally similarities differences parental influences two cultures explored results parents body mass indexes dietary behaviors positively associated young adult children mixed culture sample controlling gender high levels permissive parental authority relationships young adults parents negative participants positive chinese participants high levels parenting relationship young adults parents dietary consumption behaviors negative participants positive chinese participants conclusions study provides evidence development life long health behaviors contribute bmi significantly influenced parents behaviors parenting styles moreover interaction parental characteristics cultural norms indicated
purpose randomized controlled trials claims databases suggest drug use increase risk suicide attempts present case control study explores impact underlying indications potential association methods physicians collected medical history prior month drug use obtained standardized telephone interviews patients association use explored using multivariate conditional logistic regression analyses replicated stratification depression neurological disorders epilepsy migraine chronic pain results adults incident recruited suicide treatment centers across france socio matched controls primary care settings association use odds significant overall odds ratio confidence interval association observed patients neurological disorders opposed patients depression confounding suspected conclusions results suggest association observed use increased odds non fatal patients either lifetime history depression neurological disorder explained presence underlying psychiatric disorder accounting underlying indications crucial drug safety studies cause reported association lack thereof misleading require prospective collection medical data patient level copyright john wiley sons ltd
background common enteric parasitic infection united states causes estimated million episodes illness annually published clinical recommendations include readily available specific diagnostic testing drugs investigated sequences diagnostic treatment events using large health insurance claims database methods created longitudinal cohort persons diagnosed international classification diseases ninth revision clinical modification icd code analyzed claims occurring days days initial diagnosis evaluated differences number sequence visits diagnostic tests prescriptions age group children years adults years using chi tests data visualization software results among patients claims specific test followed concurrent effective drug without ineffective antibiotics almost two thirds patients antibiotic study window compared children adults often visits diagnosis adults also less likely specific diagnostic test likely antibiotic prescription specific tests antibiotic prescriptions examined pediatric clinical event sequences frequently began specific test whereas adult sequences frequently began prescription conclusions care follows aspects clinical recommendations multiple differences pediatric adult care despite age recommendations suggest opportunities provider education tailored guidance
important pre processing stage many machine learning pattern recognition domains feature selection identify discriminate features compact data representation typical feature selection methods variants using norm based regularization received much attention recent years however existing norm based sparse feature selection methods ignore structure information data consider pairwise relationships among samples paper propose regularized sparse feature learning method high order relationships among samples modeled incorporated learning process specifically first construct multiple capture high order relationships among samples followed computation matrix propose regularization term regularized model conduct series experiments number data sets machine learning repository two real world neuroimaging based classification tasks experimental results demonstrate proposed method achieves promising classification results compared several known feature selection approaches
modifying secondary component promising strategy improving performance water oxidation herein investigate molecular doping improve water oxidation performance water oxidation performance markedly enhanced comparison moreover improved performance composite clearly relevant type amount mechanism electron transfer also revealed spectroscopy surface measurements mechanism suggests introduction capable facilitating charge separation transport electron hole recombination elsevier rights reserved
high dimensionality classification data sets two interesting machine learning challenges issues independently studied literature order simultaneously explore issues feature selection efficiently combine two different methodological approaches unified kernel framework specifically proposed novel norm balanced multiple kernel feature selection designed proximal based optimization algorithm efficiently learning model moreover multiple kernel developed generate synthetic instances optimal kernel space induced compensate class distribution experimental results multiple data two real medical application demonstrate jointly operating nonlinear feature selection norm multi kernel learning framework lead promising classification performance
sarcoma associated latest addition human family unlike alpha beta members gamma including epstein barr virus ebv cause various tumors humans primarily endothelial cells vivo associated least three malignancies sarcoma two cell lymphomas respectively although readily endothelial cells vitro thus pathogenic mechanisms extensively studied cells refractory infection functions genes mostly elucidated endothelial cells context viral infection cells whether defined endothelial cells play roles tumorigenesis cells remains open question recently ground breaking studies cell infection models established review models compared contrasted putative mechanisms induced cell transformation discussed
human immunodeficiency virus hiv infection humans represents complex biological system great challenge public health novel approaches analysis prediction infection dynamics based multi scale integration virus immune reactions needed deal systems complexity aim study formulate multi scale mathematical model hiv infection implement model computationally following hybrid approach calibrate model estimating parameter values enabling one reproduce standard observed dynamics hiv infection blood acute phase primary infection modeling approach integrates processes infection spread immune responses lymph nodes observed blood spatio temporal population dynamics lymphocytes response hiv infection governed equations linking intracellular regulation lymphocyte fate intercellular cytokine fields describe balance proliferation differentiation death single cell level consequence gene activation via multiple signaling pathways activated distinct activation thresholds used model relate different modes cellular responses hierarchy relative levels cytokines specify reference set model parameter values fundamental processes lymph nodes ensures reasonable agreement viral load cell dynamics blood
density functional theory dft calculations performed investigate hydrogen adsorption surfaces different found surface different hydrogen adsorption strength saturated surface adsorption smallest saturated coverage thermodynamics method applied include effects temperature hydrogen partial pressure stable hydrogen coverage built phase diagram clearly revealed reaction condition dependent concentration surface theoretically predicted hydrogen desorption temperatures agreement available experimental results interestingly adsorption hydrogen also found able modify morphology catalyst based constructions calculations provide useful information reaction mechanism calculations especially hydro treating reactions hydrogen coverage surface important roles determining adsorption configurations final reaction mechanisms elsevier rights reserved
model based image analysis indispensable medical image processing one key aspect building statistical shape appearance models determination one one training data set time identification challenging part methods earlier work developed alternative method using correspondence probabilities instead exact one one statistical shape model work new approach statistical appearance models without one one proposed sparse image representation used build model combines point position appearance information time probabilistic derived multi dimensional feature vectors used need extensive preprocessing finding reduce dependence generated model positions model generation model fitting now expressed optimizing single global criterion derived maximum map approach respect model parameters directly affect shape appearance considered objects inside images proposed approach describes statistical appearance modeling concise flexible mathematical framework besides eliminating demand costly correspondence determination method allows additional constraints topological regularity modeling process evaluation model applied segmentation identification hand images results demonstrate feasibility model detect hand positions joints finger bones test images evaluated model brain data stroke patients show ability proposed model handle partially data demonstrate possible employment correspondence probabilities indicate pathological areas elsevier rights reserved
identities various analogous identities etc form family deep identities concerned integer identities written generating function form typically form product side sum side product side certain conditions sum side certain initial conditions difference conditions along possibly restrictions use symbolic computation generate various sum sides use algorithm see actually produce product sides many known identities also discover apparently new ones supported strong mathematical evidence
china faces challenge balance future urbanization process resource conservation environmental protection promoting sustainable construction identified chinese government important strategy tackle challenges promote sustainable construction chinese government released large number laws policies regulations paper investigates policy system china aims facilitate transition sustainable construction related laws policies regulations analyzed three main functions identified namely regulation control economic incentives supporting activities results show behaviours various participants construction industry including government developers designers regulated controlled laws regulations policies policies economic innovation policies adopted government promote renewable energy applications buildings infrastructure construction key supporting activities sustainable construction include strengthening technology innovation improving standards evaluation establishing demonstration projects two emerging challenges current policy system also identified lack considering social economic dimensions sustainable construction key policies environmental impact assessment policy paper provides useful reference construction policy makers china facilitate sustainable construction future urbanization process similarly policy makers emerging understand sustainable construction promoted china elsevier ltd rights reserved
ethyl methyl phenyl phenyl phenyl ethyl pre emergent used production agricultural crops carcinogenic rats cause tumors nasal causes stomach tumors causes liver tumors suggested compounds involves complex metabolic activation pathway leading dna reactive important intermediates pathway methyl produced methyl produced subsequent metabolism produces methyl para subsequent oxidation proposed carcinogenic product current study extends earlier studies demonstrates rat liver microsomes nmol min nmol min respectively whereas human liver microsomes nmol min metabolized much greater extent rat liver microsomes nmol min human liver microsomes nmol min determined rat human livers nmol min nmol min respectively nmol min nmol min respectively shown rat human liver microsomes nmol min nmol min respectively nmol min nmol min respectively also shown cytochrome isoforms responsible human metabolism
year old woman presented features right sided sinus syndrome confirmed neuroimaging although initial investigations infectious etiology subsequent investigations led diagnosis tuberculosis cause right sided sinus syndrome case illustrates although incidence tuberculosis sinus syndrome low patients originating tuberculosis endemic regions warrant investigations order miss diagnosis effect appropriate treatment elsevier inc rights reserved
voltage gated calcium channels serve dual roles cell membrane potential electrical excitability activate transient cytoplasmic signals animals channels play crucial roles including driving muscle contraction excitation contraction coupling gene expression excitation pre synaptic neuroendocrine excitation secretion coupling regulation regulation cellular excitability either directly modulation sensitive ion channels recent years genome sequencing provided significant insights molecular evolution channels furthermore expanded gene datasets permitted improved inference species phylogeny base providing insights evolution complex animal traits involve channels including nervous system various types channels key properties determine cellular contribution include ion selectivity pore gating importantly cytoplasmic protein protein interactions direct sub cellular localization functional unclear defining features many essential nervous system function evolved review highlight experimental observations channels physiology behavior early animals given limited understanding molecular biology channels basal animal lineages infer insights better studied vertebrate animals also highlight apparently conserved cellular functions channels emerged early evolution perhaps
older adults years older racial ethnic populations projected increase comparison whites non meet demand training diverse health staff long term care facilities palliative care imperative purpose study evaluate palliative care training staff two nursing homes evaluate knowledge confidence three time periods compare staff family caregiver satisfaction end program educational frameworks based cultural communication theories fifty two diverse staff majority asian participated week module training one hour communication skills workshop staff evaluation included knowledge confidence surveys pre post test knowledge tests satisfaction instrument nine asian pacific family caregivers completed satisfaction instrument overall staff knowledge confidence results promising staff rated overall satisfaction palliative care services lower family caregivers implications future research practice education palliative care training diverse nursing home staff include patient family caregiver satisfaction palliative care services evaluation effectiveness cross cultural communication theories palliative care staff training support administration development services long term care facilities
long suffered low back disorders primary injury construction studies identified several risk factors associated developed biomechanical models general risk assessments however models directly used assessments roof designed general tasks without considering posture variance effects working roof surfaces paper examined relationship work related factors risk among using laboratory assessment pitch configurable wood platform built mimic maximum trunk flexion angle normalized signals measured indicators using motion capture system skeletal muscle signal recording system different settings different roof slopes facing directions working results indicated measured factors significant effects development revealed unfavorable conditions using posture work low pitch fast pace work needs particular attention information useful systematic understanding developments among construction professionals enable development interventions guidelines reducing prevalence american society civil engineers
previous studies emphasized antisocial personality disorder psychopathy overlap highly differ critically several features notably negative possibly amygdala reactivity social signals threat distress examined whether dimensions psychopathy correlate differentially amygdala reactivity emotional faces testing relationships among healthy individuals dimensions psychopathy generated profile matching technique using facet scales neo personality inventory revised amygdala reactivity measured using established emotional faces task community sample men women higher psychopathy scores associated lower lower amygdala reactivity whereas higher scores related greater greater amygdala reactivity overlapping variance psychopathy adjusted statistical model amygdala reactivity mediate relationship psychopathy scores supplemental analyses also compared measures factors within psychopathy predicting amygdala reactivity found factor psychopathy positively related amygdala reactivity across measures psychopathy overall findings replicate observations psychopathy extend work neuroimaging normative population also suggest one critical way psychopathy dimensions differ etiology opposing levels amygdala reactivity threat
institute high energy physics beijing china started high field accelerator magnet technology recently proposed circular electron positron super proton proton project conceptual design study magnet ongoing common coil configuration model magnet fabricated next two years step process proposed realize common coil model magnet first subscale magnet fabricated investigate fabrication process characteristics coils subscale magnet fabricated test stress management method protection method coils final step common coil magnet test field optimization method coils characteristics steps introduced paper
phase detectors play essential role circuits recover clock data paper operational trans resistance amplifier based phase detector circuit proposed proposed circuit simple realize consists two based cmos circuit integrator spice simulations proposed circuit using cmos process parameters given verify theoretical analysis
live cell imaging used simultaneously capture time images angiotensin type receptors intracellular compartments transfected human embryonic kidney cells following stimulation angiotensin cells transiently transfected plasmid dna containing tagged enhanced green fluorescent protein identified red fluorescent dye live cell images captured laser scanning confocal microscope stimulation analyzed software three dimensions time live cell imaging enables investigations receptor trafficking avoids associated fixation particular loss displacement tagged membrane receptors thus individual cells tracked time subcellular localization receptors measured images acquired sufficiently rapidly capture rapid vesicle movement yet faster imaging speeds number collected reduced also made selection imaging parameters like voxel size order gain imaging speed significant applications live cell imaging study protein trafficking migration proliferation cell cycle apoptosis autophagy protein protein interaction dynamics name
based hybrid manufacturing systems capable additive manufacturing machining developed metal large components currently cad cam systems seamlessly integrate additive machining tool paths simulation required complete hybrid manufacturing solution tool paths based generated simply reversing processing order machining tool paths process planning modules significantly different machining unique process planning challenges related geometry establishing relevant process specific settings thermodynamics tool path planning realistic virtual process simulation discussed support hybrid manufacturing output additive manufacturing simulation employed stock model subsequent machining paper discusses architecture process data flows based processes results presented primarily laser
century age information great abilities information flows information technology manufacturing systems modern manufacturing seeking engineering knowledge model virtual means research presents model integrated consideration industrial cost inside manufacturing company simultaneously applies manufacturing engineering new product issues searching minimal cost delivery time managers engineers often neglect industrial possibilities inside company emphasizing processes facilities potential machinery however often limited companies often machine tools human factor seldom used properly developed model considers links among machine tools operation manufacturing time transport means time lead time products inventory production lines store developed model considers available production alternatives estimating costs integrated manner product process parameters order tasks research helps create target manufacturing cost order section paper discusses model implementation shows findings consistent patterns
background fatigue implications extend beyond individual aim aim present study evaluate impact sleep deprivation reaction time either call regular working hours moderation effect coping strategies observed methods vigilance test used assess reaction time two time points regular non call day house call students paired test used compare vigilance task data two moments change score regression performed determine association coping strategies assessed using coping strategy indicator instrument decline reaction time night call results twenty one colleagues completed vigilance test measurements two decided end participation personal reasons post call vigilance test mean reaction time decreased average compared regular day reliance specific coping mechanisms indicated coping strategy indicator scale scores included problem solving followed seeking social support avoidance change score regression model found greater reliance avoidance associated greater increase reaction time night call conclusion reaction time increased considerably night call duty greater subjective reliance avoidance coping strategy associated greater deterioration performance
mirror neuron system crucial component underlying human social cognition initial evidence based functional magnetic resonance imaging fmri suggests plays role emotion classification confirmation convergent evidence needed study employed electroencephalography eeg examine rhythm associated inference emotions facial expressions hypothesised suppression associated classifying emotion facial expressions nineteen participants viewed pictures facial expressions emotion words asked either match stimulus emotion word observe activity following stimulus presentation using distributed inverse solution compared conditions logic used isolate specific processes interest comparisons source images conditions revealed suppression associated emotion faces thereby supporting hypothesis analyses confirmed effects due activity associated motor response observation facial expressions offering support hypotheses study provides important convergent evidence involvement inference emotion facial expressions
similar ubiquitous cell biology important vector drug delivery mechanical properties vesicles known influence cellular uptake mechanism deformation dynamics affect internalization poorly understood partly due fact experimental studies mechanics vesicles remain challenging particularly nanometer scale appropriate theoretical models also lacking probe mechanical properties nanoscale using atomic force microscopy mechanical response shows initial linear behavior subsequent corresponding formation derive quantitative model including competing effects internal pressure membrane bending corresponds experimental observations results consistent bending modulus lipid similar surprisingly find vesicle stiffness pressure dominated vesicles physiological conditions experimental method quantitative theory represents robust approach study mechanics nanoscale vesicles abundant biology interest rational design vectors drug delivery
carrying teaching professional courses graduate students inevitable trend education development reform also important measure make domestic higher education connect international education basis concept teaching necessity feasibility develop teaching course advanced manufacturing engineering analyzed detail based teaching practice several years several instruction methods proposed furthermore issues teacher student interactive teaching proportions using english teaching application multi media teaching discussed researched comprehensively view making students master professional knowledge improve english skill
paper implementation training modules presented teaching support area power semiconductor devices practical learning discipline system composed five modules allow development different applications power electronics including power electric control prototypes developed aim student validate test typical circuits employed topic easy intuitive form
military police health care personnel particularly interested operational impact sleep restriction work schedules given potential severe consequences making fatigue related errors studies examining impact sleep loss circadian manipulations conducted controlled laboratory settings using small sample sizes study examined whether relationship prior night sleep duration performance vigilance task reliably detected field study healthy police academy subjects medically healthy sleep wake activity assessed wrist actigraphy days subjects performed vigilance task min personal digital device police academy comparable times days mixed effects logistic regression used estimate probability function previous night sleep duration days field testing valid estimates sleep duration obtained sleep probability decreased sleep night prior testing overall probability decreased since holding hours sleep constant perceived stress associated sleep duration probability performance findings demonstrate feasibility detecting sleep circadian effects cognitive performance large field studies findings implications regarding daytime functioning police author correspondence
gain boosted operational amplifier designed using positive feedback technique presented paper design differential output differential amplifier merged single output differential amplifier used positive feedback applied appropriately proposed amp designed cmos process using library cadence analog design environment simulation proposed circuit results gain degree phase margin power consumption monte carlo analysis circuit indicates variation power supply voltage produces minimal effect gain phase circuit
objectives despite recent advances perioperative management postoperative atrial fibrillation flutter remains common complication cardiac surgery therefore important determine related risk factors establish effective management however studies focused patients undergoing coronary artery bypass grafting little known receive aortic valve replacement investigated relationship clinical predictors patients undergoing methods total patients underwent enrolled study relationships incidence perioperative preoperative operative postoperative factors examined results occurred patients univariate analysis older age significantly associated occurrence significantly related prolonged intensive care unit icu stay postoperative stroke also showed patients preoperative beta blocker experienced less frequently without beta blocker multivariate analysis showed preoperative beta blocker usage independent predictor patients received preoperative oral postoperative intravenous beta blocker incidence reduced conclusions frequently occurred patients undergoing significantly related prolonged icu stay postoperative stroke findings show advanced age absence preoperative beta blocker usage risk factors furthermore patients undergoing perioperative intravenous beta blocker administration useful prevention
paper introduces high frequency soft switching pulse width modulation power converter secondary active rectifier tested current source arc welding applications soft switching converter consists high frequency full bridge inverter high frequency power transformer controlled output rectifier new secondary energy recovery turn circulating currents converter reduced using active rectifier rms values currents primary secondary switches decreased utilizing novel control algorithm experimental results converter working switching frequency presented
global signal widely used normalization factor removing effects global variations analysis functional magnetic resonance imaging fmri studies however considerable controversy use potential bias introduced applied analysis task related resting state fmri studies paper take closer look global signal examining detail various sources contribute signal part global signal treated term growing evidence also contain valuable information also examine various ways global signal used analysis fmri data including global signal regression global signal global signal normalization furthermore describe new ways understanding effects global signal regression relation approaches
paper study real time implementation position control based electric drive information contained within paper serves framework expand usefulness electric drives addition digital control systems switching power supplies tangible example driven permanent magnet motor position control used relate work apply various mechanical systems tasks accomplished achieve electric drive position control follows determining parameters motor designing control system direct motor desired verifying performance system use computer simulations real time hardware loop experimental testing
introduction chronic myeloproliferative disorders chronic myeloid hematological disorders characterized increased myeloid cell proliferation fibrosis impaired apoptotic mechanisms increased cell proliferation uncontrolled hematopoietic cell proliferation contribute pathogenesis aim study show possible role fas gene polymorphisms pathogenesis investigate association clinical parameters susceptibility disease material methods included polycythemia vera primary myelofibrosis pmf essential thrombocythemia patients diagnosed according classification criteria healthy controls study patients controls investigated fas gene expression allele frequencies phenotype features also fas mrna levels analyzed results chronic myeloproliferative disorders patients showed increased fas genotype distribution compared control group gene polymorphism clinical parameters splenomegaly thrombosis statistically significant difference genotype allele frequency found groups moreover statistically significant difference detected mutations fas mrna expression fold reduced patients compared healthy subjects conclusions according findings fas gene expression contribute molecular immunological pathogenesis investigations needed support data
functioning hematopoietic system requires certain robustness flexibility maintain appropriate quantities functional mature blood cells red blood cells platelets review focuses cytokine receptor plays significant role receptor also known mpl survey work date understand receptor functions molecular level throughout lifecycle traffic cell surface binding cytokine via extracellular domain subsequent activation associated janus kinases initiation downstream signaling pathways regulation processes atomic level resolution structures remained elusive identification disease causing mutations receptor however offered insight structure function relationships artificial means receptor activation transmembrane targeting receptor agonists engineering domains recently novel activation mechanism identified whereby mutated forms form complexes via extracellular domain complexes traffic cell activate downstream signal transducers transcription pathways pathologic activation associated large fraction human myeloproliferative neoplasms
detailed ige binding epitope analysis key requirement understanding development diagnostic therapeutic agents address food allergies ige specific linear peptide microarray random peptide display high resolution mapping ige binding epitopes major soybean allergen pollen allergen bet combined three epitopes identified mapped resolution four key amino acids allowing rational design production three mutants aim reduce binding epitope specific ige elisa binding mutant allergens polyclonal rabbit anti serum ige purified reactive soybean allergy patient sera reduced compared wild type allergen stimulation experiments using cells loaded patient ige showed decreased stimulation wild type one mutant presented approach demonstrates feasibility precise mapping allergy related ige binding epitopes allowing rational design less mutants potential therapeutic agents
last years focus computer science education primary secondary schools shortly reached significant turning point study reviews published papers field computing education order summarize findings guide future studies give reflections major achievements area schools peer reviewed articles collected systematic literature search analyzed based categorization main elements programming tools educational context instructional methods main examined categories research results survey show direction schools research last years summarized benefits challenges particular analyzed selected papers perspective various instructional methods aiming introducing enhancing learning using several programming tools educational context despite challenges findings suggest implementing computing lessons education effective learning experience addition suggest ways facilitate deep learning deal various implications formal informal education encouraging students create projects solve problems significant part learning process
paper presents highly resolved large eddy simulations les internal combustion engine ice using immersed boundary method describe moving stationary boundaries simple efficient manner novel approach motion valves piston modeled lagrangian particles whilst stationary parts engine described computationally efficient proposed mesh free technique boundary representation simple parallelization suitable high performance computing hpc demonstrate method les results presented flow combustion internal combustion engine filtered navier stokes equations solved flow employing finite volume method grids non reflecting boundary conditions applied intake exhaust ports combustion described using flame surface density model algebraic reaction rate closure simplified engine fixed valve see employed show correctness method avoiding uncertainties induced complex engine geometry three test cases using real engine geometry investigated different grids evaluate impact cell size filter width simulation results compared experimental data good overall agreement found measurements simulation data presented method particular advantages efficient generation grid high resolution low numerical dissipation throughout domain excellent suitability massively parallel simulations
helper dependent autoimmune responses develop heart lung transplantation associated forms chronic rejection however specific self antigens involved typically different associated autoimmune disease investigate basis responses investigated whether removal regulatory cells blockade function reveals similar bias found cells specific collagen type vimentin present healthy adult peripheral blood mononuclear cells cord blood fetal thymus using synthetic peptides recombinant fragments triple helical region compared cells healthy donors cells reactive heart lung patients although latter responded fragments peptides hla restricted fashion cells healthy persons responded hla restricted fashion fragments peptides vimentin preferred targets highly conserved hitherto unknown preexisting response mhc class restricted data suggest autoimmunity heart lung transplantation result dysregulation intrinsic mechanism controlling airway vascular homeostasis
world establishing successful cooperation people different nations becoming increasingly important present results comprehensive investigation cross societal cooperation one shot involving population representative samples six countries identify crucial facilitators obstacles cooperation interactions involving mutual knowledge players demonstrate people hold strong shared expectations stereotypes concerning cooperation level interaction partners countries expectations strongest determinants participant cooperation paradoxically however turn incorrect stereotypes even correlate negatively reality addition erroneous expectations participants cooperation behavior driven shared social preferences vary according interaction partners cross societal context social preferences influenced differences wealth ingroup effects specific country combinations spatial distance nations
background number significant recent research studies used techniques economic modelling demonstrate potential benefits increasing breastfeeding rates overall specifically neonatal care paper growing body evidence presenting economic analysis data actual intervention getting right start programme took place north aim increasing breastfeeding skin skin care rates neonatal units methods getting right start pragmatic multifaceted programme change delivered regional health innovation education cluster established engaged neonatal units two neonatal networks aim increasing skin skin care breastfeeding rates part evaluation programme conducted economic study comparing overall costs benefits intervention results overall economic analysis demonstrated every intervention increase skin skin care breastfeeding rates benefit generated spread across different healthcare settings benefits vary increases skin skin care generated greatest cost savings potential cost savings ranging minimum cost assumptions maximum cost assumptions increases breastfeeding associated project generated majority cost savings generated associated reductions cases conclusion one first economic evaluations actual intervention increase breastfeeding skin skin care neonatal units existing economic models demonstrating real intervention clinical practice cost effective clinically beneficial future interventions similar methodology supported considered likely generate significant cost savings compared economic evaluation frequently included studies practical interventions clinical settings increase breastfeeding
vitamin fat soluble vitamin steroid hormone plays central role maintaining calcium phosphorus bone homeostasis close interaction parathyroid hormone acting classical target tissues namely bone kidney intestine parathyroid glands however vitamin endocrine system regulates several genes human genome involved cell differentiation cell cycle control cell function exerts pleiotropic effects target tissues immune cardiovascular system pancreatic endocrine cells muscle adipose tissue several studies demonstrated role vitamin supplementation prevention treatment various autoimmune diseases improvement glucose metabolism muscle adipose tissue function hence review aims elucidate effects vitamin target tissues investigate potential therapeutic benefit vitamin supplementation among broad group pathological conditions especially regard metabolic autoimmune diseases addition focused best daily intakes serum levels vitamin required benefits even still controversial appear higher widely accepted skeletal effects
occurrence fish male reproductive tissues show evidence found freshwater systems around world indicating potential significant endocrine disruption across species ecosystem estrogens birth control medications wastewater treatment plant effluent cited likely cause research shown endocrine disruption solely predictable based hormone receptor interactions many non hormone pharmaceuticals found effluent concentrations orders magnitude higher estrogens yet little data indicating impacts medications widely prescribed anti diabetic among abundant pharmaceuticals found effluent structurally hormones however show exposing concentration found wastewater effluent causes development males reduced size treated male fish reduction treated pairs results demonstrate acts endocrine environmentally relevant concentrations authors published elsevier ltd
last decade china implemented public private partnership projects water sector compared sectors however efficient management risks projects remains problematic many studies examined risks associated china experience local governments risks received little attention literature moreover stages risks significant risks interrelated researched paper examines risks experienced local governments perspective manifest across five stages feasibility procurement construction operation transfer risks across stages also examined data collected via questionnaire surveys interviews analyzed using quantitative qualitative analysis findings reveal critical risk local governments impacts vary across project stages risks influence risks within across five stages findings provide significant insight dynamic nature risks water projects important implications practitioners developing risk mitigation strategies american society civil engineers
major causative agent fungal infection japan recent sequence analysis internal transcribed regions ribosomal rna gene shown species separated three species cell walls fungi including genus contain important virulence synthase enzyme required synthesis study analyzed phylogeny strains isolated japan sequencing gene regions identifying molecular polymorphism sixty strains morphologically identified isolated worldwide including strains isolated japan analyzed regions ribosomal rna gene part gene region amplified yielding sequences approximately respectively polymerase chain reaction products sequenced cluster analysis performed proposed phylogenetic tree based sequences closely matched based regions sequencing regions showed isolates japan belonged molecular variations japanese strains evaluated assessing sequences isolates divided least seven molecular subtypes combination two molecular markers provides robust method epidemiological study
background physical activity play role preserving kidney health purpose study determine sedentary behavior associated incident chronic kidney disease ckd change kidney function older adults methods health aging body composition study prospective cohort functioning older adults television watching measured self report serum used estimate glomerular filtration rate egfr ckd defined min discrete survival analysis used determine baseline television watching related year cumulative incidence ckd rapid decline kidney function results individuals reported watching television hours day higher risk incident ckd experiencing rapid decline kidney function compared individuals watched television hours day related either outcome conclusions high levels television watching associated declining kidney function mechanisms underlie association need study
grafting bone grafting type minimally invasive hip preserving procedure stable clinical curative effects standard operation procedure however requires difficult technique series complex procedures therefore discovery new methodology surgical guidance lead accurate safe easily performed surgeries play crucial role promotion application september july one surgeon performed patients males females average age years range years using patient specific surgical guides patients underwent preoperative ray examinations mri scans surgery performed preoperative planning patient specific surgical guides computer aided design cad length bone tunnel bone mass percentage volume percentage surface area measured surgery ten placed patients diagnosed implants successfully placed using patient specific surgical guides application patient specific surgical guide operating times min average min blood loss volumes average operative sizes average mean hospital stay cases followed months average months conclusions patient specific surgical guidance enable intuitive precise preoperative planning hip preserving procedures
background aims proposed modification leaf size driven epidermal cell size leaf water supply determined veins demand generated local irradiance aimed determine whether general pattern among plant species contrasting growth habits methods compared observed relationships leaf minor vein density density epidermal cell size leaf size four pairs species families grown sun conditions modelled relationships assuming vein densities respond epidermal cell expansion leaf content also quantified assess whether construction costs leaf veins differ plants leaf mass fraction veins key results modelled relationships accurately described observed relationships indicating species changes density minor veins mediated common relationship epidermal cell size vein density density little impact index independent changes leaf size likely adaptive process driven significant proportion biomass veins center dot sun leaf dry weight center dot leaf dry weight relative costs increased selective pressure towards investment vein density conclusions modulation epidermal cell size appears general mechanism among experimental species maintain constant ratio leaf anatomical traits control leaf water fluxes independently habit propose process plasticity hydraulic supply demand majority
three phase common mode widely used electric motor drives means limit ground current shaft voltage electromagnetic interference emission switching frequency power converters keeps increasing help high performance switching devices sic role becoming increasingly important paper presents comprehensive analysis magnetic design sizing three phase analytical calculation critical parameters leakage inductance capacitance flux density losses addressed paper design constraints determine size magnetic cores also shown finally systematic design procedure minimizes inductor size proposed verified
robust analytical method required determination low molecular weight organic acids potential causes internal combustion engine corrosion ion chromatographic method developed study allows determination acetic acid acid diesel oil mixtures motor oil volume fraction hydrophobic matrix automatically removed line matrix step organic solvent anion exchange extraction acetic acid acid smallest acidic acids determined gradient anion exchange chromatography high capacity columns combination suppressed conductivity detection allowed selective sensitive determination typical recovery values acid matrices evaluated reproducibility less acid samples
modern digital data production methods computer simulation remote sensing increased size complexity data collected spatial domains analysis large spatial datasets scientific inquiry typically carried using gaussian process however behavior computational requirements large spatial datasets efficient implementation gaussian process models perform computationally feasible inference large spatial data consider partitioning spatial region sets using hierarchical clustering observations finite differences measure directions large finite differences indicate directions rapid increase decrease therefore appropriate partitioning spatial region spatial resulting clusters clustering neighbors following spatial clustering propose gaussian process model across clusters allows computational burden model fitting distributed across multiple cores nodes methodology primarily motivated illustrated application validation digital temperature data city simulated datasets supplementary materials article available online
agrobacterium tumefaciens mediated transformation system established using leaf explants strain carrying genes sensitivity leaf explants standardized screening transgenic plants transformation parameters virulence inducer infection time cultivation period antibiotics etc influencing gene transfer integration assessed present investigation fourteen day pre cultured explants subjected agrobacterium strain optimized parameters culture density infection time min concentration days cultivation revealed maximum transformation efficiency based gus expression assay presence confirmed polymerase chain reaction southern blotting analysis present transformation experiment yielded shoots higher transformation efficiency protocol used introduce genes trait improvement altering metabolic pathway secondary metabolites production
adsorption removal aqueous solutions synthesized activated carbon beads ammonium bromide studied using two ways traditional method two step first synthesized modified used remove adsorption one step method dispersed wastewater followed removal accompanied synthesis one step method showed better performance two step method achieving maximum removal kinetic studies adsorption indicated adsorption process one step method expressed pseudo second order model isotherm respectively effects ionic strength inorganic ions adsorption also investigated furthermore hydrophobic interactions hydrogen bonds electron donor acceptor interactions discussed explain enhanced adsorption behavior findings verified effectiveness removal wastewater high stability within five regeneration cycles elsevier inc rights reserved
herein present case years male total absence pulmonary veins potentials beginning first procedure paroxysmal atrial fibrillation demonstrating conduction left revealed adenosine relation incidence free atrial arrhythmias year follow complete isolation elimination multiple transient circular mapping catheter guide ablation
paper presents results model predictive controller mpc methodology applied case cooling system internal combustion engine end small spark ignition engine displacement volume equipped electric pump actuated controller independently engine speed goal proposed control achieve faster engine warm effective engine cooling much lower coolant flow rate one usually adopted bringing cooling system operate around onset developed model predictive control application makes use lumped parameter model predicts heat transfer case single phase forced convection condition presence performance proposed controller evaluated city driving part cycle replicated engine test rig results show proposed controller robust terms disturbance rejection effective reducing warm time authors published elsevier ltd open access article license
crystal structure metal plays important role relationship macroscopic properties atomic mechanisms structural change students need ability visualize planar crystal atomic features often find difficult thus research question students baseline knowledge misconceptions planar atomic features different metal structures measured instruction promote conceptual change repair answering question provide insight developing effective crystal structures multiple choice survey six items developed using misconceptions students pencil paper face centered cubic body centered cubic atoms planes survey administered students spring introductory materials engineering course misconceptions revealed included missing atoms extra atoms atoms non atoms touch atoms touch students difficulty solving increased planes structures details survey instrument results described paper
introduction many forms interstitial lung disease ild progress extensive fibrosis respiratory failure idiopathic pulmonary fibrosis ipf generally poor prognosis thoroughly studied past two decades many important discoveries made genetic predisposition epidemiology disease pathogenesis diagnosis management additionally non ipf forms ild manifestations mimic ipf making accurate diagnosis key providing personalized medicine patients pulmonary covered manuscript discusses current knowledge pertaining genetics epidemiology pathogenesis diagnosis pulmonary fibrosis emphasis ipf material upon discussion based obtained various published texts identified via literature searching pubmed expert commentary many genetic variants identified associated risk developing pulmonary fibrosis improved understanding influence genomic factors development pulmonary fibrosis rapidly evolving many forms ild similar patterns yet different responses therapeutic interventions making accurate diagnosis specific forms pulmonary fibrosis increasingly important
realistic animation expressive human face great challenge computer graphics due human perception human faces complex costly time consuming process requiring great detail many aspects paper three stage method presented simplifies creation realistic facial transferring expressions videos onto models joint based system real time basis first stage covers preparation model joint based rig transfer second includes real time tracking human face single camera obtain positions facial also covers transfer relative movement data prepared model moving respective joints last stage covers recording animation using partially automated key framing technique presented method provides fast easy use affordable system produces visually satisfying facial
simplify deployment maintenance ambient intelligence solutions important enable large scale deployment maximize use benefit solutions mature ambient intelligence solutions emerge market result intensive investment research research targets mainly accuracy usefulness usability aspects solutions still possibility adapt different environments ease deployment maintenance ongoing problems ambient intelligence existing solutions require expert move site order install maintain systems therefore present paper attempt enable quick large scale deployment discuss lessons learned approach deployment process order performed ordinary people also introduce solution simplifying monitoring maintenance installed systems
introduction order establish use national registry several centers collected data myeloproliferative patients aim recent publication analysis data registered essential patients method online electronic registry established using world health organizations diagnostic criteria thrombotic risk evaluated according stratification results data essential patients centers entered date june used analysis patients followed median years epidemiologic data age gender thrombotic events prior diagnosis similar literature thrombotic events treated patient hydroxyurea aspirin treated patients compared major arterial venous events similar groups less minor arterial venous events group thrombotic incidence diagnosis influenced medication thrombotic events diagnosis conclusions significantly decreased number patients experiencing minor arterial minor venous thrombosis hydroxyurea aspirin despite treatment risk thrombotic events diagnosis remained high significantly increased patients thrombosis diagnosis
importance neuro immune interactions physiological pathophysiological states appreciation nature brain spinal cord grows need extend spatial temporal resolution molecular analysis techniques current imaging technologies applied investigate actions system health disease states adapted fields immunology neuroscience classical techniques provided immense insight function cns however inherently limited thus development innovative methods overcome limitations crucial imaging quantifying acute chronic responses therefore review aims convey emerging novel complementary imaging technologies form accessible medical scientists engaging research elsevier inc rights reserved
given large amount information encounter often prioritize information attempt remember although critical everyday functioning relatively little research focused people prioritize encoding information recent research shown people selectively remember information assigned higher relative lower importance however mechanisms underlying prioritization process consequences processes still understood present study sought better understand prioritization processes whether implementing processes comes cost memory accuracy increasing false memories used modified form deese roediger mcdermott drm paradigm participants studied drm lists list paired low medium high point values experiment encoding higher values led false memories encoding lower values possibly information enhanced relational processing among high value words experiment disrupting relational processing selectively reduced false memories high value words finally experiment facilitating relational processing selectively increased false memories low value words findings suggest information enhance true memory process concomitantly increases false memories furthermore mechanism underlying prioritization processes depends ability successfully engage relational processing thus prioritize encoding incoming information come cost terms accurate memory
patients social cognition deficits require therapists special skills ensure treatment success specific remediation techniques teach patients look relevant emotional cues interacting people tested adjunctive treatment
previous studies shown seeing another person live direct gaze results enhanced skin conductance responses indicating autonomic arousal greater relative left sided frontal activity electroencephalography asymmetry alpha band power associated approach motivation studies however stimulus persons neutral expression real life social interaction eye contact often associated another signal approach related motivation therefore enhance affective motivational responses eye contact present study investigated whether facial expression neutral social modulate autonomic arousal frontal eeg alpha band asymmetry seeing direct gaze faces presented live liquid crystal results showed greater direct gaze effect gaze direction pronounced neutral face however study gaze direction facial expression affect frontal eeg asymmetry although gaze direction found marginally significant correlation degree overall bias asymmetric frontal activity degree direct gaze elicited stronger left sided frontal activity gaze
food potent natural reward food intake complex process reward associated food consumption leads dopamine production turn activates reward centers brain individual repeatedly eat particular food experience positive feeling type repetitive behavior food intake leads activation brain reward pathways eventually signals thus habit favorable food leads morbid obesity obesity stems many biological factors engaging central peripheral systems directional manner involving mood emotions emotional eating altered mood also lead altered food choice intake leading obesity research findings human animal studies support two way link three concepts mood food obesity focus article provide overview complex nature food intake various biological factors link mood food intake brain signaling peripheral central nervous system signaling pathways directional manner obesity
investigation paper dimensional type equation describe propagation nonlinear waves shallow water waves surface internal waves virtue bell polynomials symbolic computation auxiliary independent variable bilinear forms backlund transformations soliton solutions obtained propagation elastic collisions among two three solitons discussed analytically graphically seen collision shapes amplitudes keep invariant except phase shifts smaller amplitude soliton moves faster larger
goal research study effect substitution wheat starch potato starch performance health digestion growing rabbits three experimental diets formulated respectively similar starch contents dry matter basis proteins fibre three diets administered three groups rabbits weaning days days growth health measurements made another rabbits per diet rabbits age similar conditions weeks age collected analyse microbial activity volatile fatty acids levels activity starch concentration ages whole tract coefficients measured rabbits treatment rabbits feed intake days age days increased whole growth period days weight gain similar among diets day whereas feed intake feed conversion increased respectively diet mortality morbidity affected diets starch concentration contents increased addition diet diets respectively starch percentage units higher diet diet bacterial activity tended higher diet total concentration increased week old rabbits compared mmol protein starch concentration decreased age weeks increased weeks age rabbits showed higher pool mol proportion lower proportion acetate ammonia level mmol ratio weeks age intake potato starch effect performance microbial activity digestive health growing rabbits
objective determine pharmacy availability ulipristal acetate upa compare availability levonorgestrel containing emergency contraceptive pills lng methods conducted observational population based study utilizing telephone based secret methodology researchers called unique retail december june representing patients physicians results upa immediately available though reported ability order upa contrast reported immediate availability lng significant difference availability reported patients physicians conclusions availability upa limited significantly lower compared lng study period overlap change upa likely capturing disruption supply chain elsevier inc rights reserved
really like although research suggests answer yes current study demonstrates answer question simple study participants completed survey responded measure trait randomly assigned rate people described either traits abstract trait description condition behavioral manifestations traits concrete behavior description condition results showed non rated others significantly positively abstract trait description condition whereas effect non significant slightly reversed concrete behavior description condition interestingly interaction effect modified contextual salience ones non identity sum present research presents case claim traits follow claim led manifestations traits finding adds growing body work examining attitudes toward elsevier ltd rights reserved
behaviors pool dynamically coupled controlled pulse plasma arc welding used indicate quality vision system improved detect geometries pool simultaneously whole controlled pulse period one single camera without auxiliary illumination assistance appropriate optical filter system unchanged aperture exposure time camera also adopted used different current period image processing method proposed extract boundary open status pool boundary whole welding process influences current waveform parameters welding process studied discussed found dimensions pool determined heat input plasma arc duration moves forward welding process pool maximum width located behind center
objective establish three dimensional finite element model ankylosing spondylitis digital platform studies methods year old man underwent computed tomography transverse scanning images imported mimics software establish model posterior spine imported software posterior spine convex geometry established geometric model subsequent optimization image processing produced spinal surface model modeled calcification partial resection sacral bone added model imported ansys analysis software added parameters set generate model results conclusion model successfully established providing reliable digital platform subsequent biomechanical analysis
objective examine impact sleep duration lung function asthma symptoms adolescents methods ten adolescents asthma female caucasian mean age years range completed week randomized cross sleep manipulation protocol following week self selected sleep duration adolescents randomized five night deficient sleep opportunity bed healthy sleep opportunity bed obtained systematically changing wake time remained consistent across weeks including daily reports sleep patterns asthma symptoms actigraphy daily peak flow rates weekly exhaled nitric oxide collected results participants averaged less sleep per night short sleep condition versus long sleep condition decrease reported asthma symptoms interfering activities past short sleep condition long sleep condition significant differences experimental weeks found weekly exhaled nitric oxide conclusions pilot study demonstrated feasibility cross sleep manipulation protocol adolescents asthma since decrease marker nocturnal asthma associated severity daytime airflow limitation early stage results suggest shortened sleep duration exacerbate adolescent asthma associated functional impairments wiley periodicals inc
rapid proliferation technologies introduced applications inventory sampling inspection conventionally systems reader usually identifies tags region maximum power however applications need identify tags specified area usually smaller readers default region example identifying tags box ignoring tags box paper respectively present two solutions identify tags specified area principle solutions compared picture taking process auto focus camera firstly focuses target automatically takes picture similarly solutions first focus specified area shoot tags design two solutions based extensive empirical study tags realistic experiment results show solutions reduce execution time percent compared baseline solution identifies tags maximum power furthermore improve proposed solutions make work complex environments
objective introduction health information technology systems electronic health records particular changing nature clinicians interact patients lack knowledge remains best integrate systems exam room purpose systematic review best behavioral communication practices recommended literature clinicians interacting patients presence computerized systems clinical encounter evidence recommendation rank evidence based recommendations electronic health record communication training initiatives clinicians methods conducted literature search databases resulting articles included analysis extracted information study setting research design sample findings implications recommendations based consistent support behavioral communication practices across studies results eight behavioral communication practices received strong support evidence literature included specific aspects using computerized systems facilitate conversation transparency exam room spatial organization exam room maintaining nonverbal communication specific techniques integrate computerized system visit engage patient four practices although patient centered received insufficient evidence date discussion conclusion developed evidence base best practices clinicians maintain communications presence computerized systems exam room work includes development empirical evaluation evidence based guidelines better integrate computerized systems clinical care
motivated terms mathematical concepts theory electrical networks introduced studied new graph theoretic index global index paper utilizing techniques graph theory electrical network theory real analysis obtain results new measure including strictly increasing property lower upper bounds type results particular establish relationship global index number connected graph vertices edges elsevier rights reserved
paper extend several known document problems case documents contain approximately matches query pattern study scenario query string contain symbol matches symbol documents match query pattern one describe linear space data structure reports documents containing pin vertical bar vertical bar sigma root time sigma size number listed documents also describe solution problem solution extension problem furthermore approach enables obtain sigma space data structure documents containing pattern pattern special case differ one symbol published elsevier
environmental hormonal factors implicated multiple sclerosis investigated whether prominent contaminant endocrine disrupting capabilities altered susceptibility inflammatory model multiple sclerosis found gestational adult exposure increased development experimental autoimmune encephalomyelitis adulthood male female mice suboptimal disease inducing immunization used gestational male mice primed macrophages adulthood raised colony stimulating factor neutrophil counts activity immunization neutralizing stimulating factor blocked susceptibility disease mice early life exposure represent environmental consideration multiple sclerosis
serves mammalian cell derived gaseous neurotransmitter exposed second source gas sulfate reducing bacteria binds rendering insoluble aim study test hypothesis slow intestinal transit reversible fashion mice randomized five groups consisting live saline vulgaris common strain administered gavage dose cells along fluorescent dye intestinal transit measured gavage animals removing small intestine valve visualizing distribution across intestine using imaging system intestinal transit compared using geometric center minimal movement maximal movement concentration also measured small intestinal luminal content allowed generate gas key resultsthe live group slower intestinal transit represented geometric center score compared saline correspondingly live group highest luminal concentration compared group conclusions slow intestinal transit reversible fashion mice results demonstrate intestinal transit effect abolished binding
ensemble weather predictions introduced operation district heating systems create heat load forecast dynamic uncertainties provide new valuable tool time dependent risk assessment related security supply energy markets useful production planning online operation modern district heating system particular light low temperature operation integration renewable energy close interaction electricity markets paper simple autoregressive forecast model weather prediction input used new concept study period performance comparable complex forecast models total uncertainty heat load forecast divided constant model uncertainty plus time dependent weather based uncertainty latter varies much factor depending ensemble spread consequence total forecast uncertainty varies significantly forecast model applied operation three heat exchanger stations applying optimized temperature control significantly lower supply temperatures compared current operation improving temperature control dynamic time dependent weather based uncertainties lower supply temperature reduce heat losses ground potential benefit using dynamic uncertainties larger systems relatively smaller pumping capacities elsevier ltd rights reserved
study represents continuation previously performed study use development online method determining iodine number porcine adipose tissue use near infrared spectroscopy original study fat tissue measured function depth skin thus represent spatial near infrared data measured across porcine represents data pig data structures largely ignored original publication explored multivariate curve resolution massive amount near infrared data spectra true five way array horizontal position vertical position depth spectral data points two way matrix sample spectra maintaining spatial data separate array multivariate curve resolution applied two component multivariate curve resolution model proved fit data nearly perfectly variance explained concentration highest component found fat second component found water surprisingly latter found vary strongly iodine value fat resulting multivariate curve resolution model folded back original spatial dimension produce maps showing distribution constituent concentrations adipose tissue
extensive application rainwater harvesting rwh projects inhibited challenge posed dry seasons case study primary school performance rwh system evaluated using daily water balance model methodology based defined dry season parameters water days rainwater usage ratio water level local water system operational methods involve users adopting either fixed constant demand variable demand demand varying respect available water storage tank throughout system utilization additionally cost installing rwh system achieve substantial reduction zero calculated established existing system achieve zero consideration operational methods however greater number tanks lower variable demand operational method better achieved mitigating water dry season school adopt rwh two buildings demand scenario demand respective water levels storage tanks yielding performance system improved monitoring water levels demand guidelines useful strategies practitioners water supply
potentially severe adverse effect although risk increases increasing duration treatment currently reliable estimates time onset objective study estimate associated risk factors treated patients subjects analysis data secondary care centres seven countries relevant patients developed related resultsthe median years patients treated treated multivariable cox regression showed surgery inversely associated use directly associated patients cancer treated conclusionsthe incidence increases duration therapy notable differences observed respect type potency route administration underlying disease data stratified type time oral intravenous therapy respectively required patients develop stratification disease time therapy required patients osteoporosis cancer respectively develop findings significant implications design future clinical studies development risk reduction strategies aimed either assessing modulating risk associated
cyclic amp determined play important roles bacterial physiological processes human metabolism respectively however methods developed use fluorescent sensors sense amp real world address challenge study presents fast convenient selective sensitive assay quantifying amp fluorescence based competitive binding nucleotides probe designed probe consists adenosine base unit end unit end coordination causes change conformation random coil folded structure thus enabling close result fluorescence quenching occurs two organic dyes probe encounters nucleotide resulting complex nucleotides forces removal probe conformational change probe leads restoration fluorescence within short analysis time min proposed probe provides high selectivity toward amp common nucleotides probes detection limit signal noise ratio amp estimated respectively practicality proposed probe demonstrated quantifying amp bacteria human tears
changes chromatin structure regulate gene expression genome maintenance molecules bind complex dna histone proteins key modulators chromatin structure previous work indicated cholesterol ubiquitous cellular lipid bind chromatin vivo suggesting potential function lipids modulating chromatin architecture however molecular mechanisms action chromatin structure remained unclear explored biophysical impact cholesterol chromatin fibers vitro characterized silico cholesterol binding findings support cholesterol chromatin formation induces folding long chromatin fibers result direct interaction cholesterol six binding sites
characteristic feature idiopathic pulmonary fibrosis ipf accumulation apoptotic resistant fibroblasts foci null mice develop pulmonary fibrosis hypothesized participating fibroblasts display apoptosis resistant phenotype test hypothesis identify molecular mechanisms involved isolated lung fibroblasts null mice examined expression several inhibitors apoptosis bcl proteins death receptor fas found significant increase constitutive protein expression alteration bcl lower levels fas isolated fibroblasts treated fas ligand induce apoptosis morphological biochemical alterations induced similar wild type null mouse lung fibroblasts time course extent alterations greater null fibroblasts several salient features null fibroblasts response loss membrane potential fragmentation mitochondrial continuum concurrent caspase activation subsequent bid cleavage prior caspase activation detected furthermore antigen formation expression dna fragmentation caspase dependent sirna mediated silencing individually combined enhanced sensitivity lung fibroblasts induced apoptosis pharmacological inhibition bcl effect together findings support mechanism fas engagement activates caspase inducing mitochondrial apoptosis bid cleavage fine tune process cell type specific manner
disclosure sexual gender minority status associated positive negative effects wellbeing studies explored disclosure process young people interviews conducted sexual gender minority individuals aged male birth sex data analyzed qualitatively yielding determinants effects disclosure determinants disclosure included holding positive attitudes ones identity implicit acceptance society coming shown positive negative effects communication social support associated increases decreases experiences stigma determinants included lack comfort ones identity various motivations avoid discrimination also related unique strategies accessing social support results discussed light clinical implications
bioinformatics term body biological studies use computer programming part methodology reference specific analysis pipelines repeatedly used particularly fields genetics genomics data mining interdisciplinary computer science computational process discovering patterns large data sets involving methods intersection artificial intelligence machine learning statistics database systems overall goal data mining process extract information data set transform structure use common uses data mining bioinformatics include identification candidate genes nucleotides snps paper proposed association rule mining strategy discovery snp cancer sequences
association increased serum concentrations substances early menopause reported association explained fact women underwent menopause longer objective assess much epidemiologic association altered timing menopause explained reverse causality extended published population life stage physiologically based pharmacokinetic model characterized realistic distributions physiological parameters including age menopause conducted monte carlo simulations replicate population population analysis simulated data overall showed pattern results comparable reported epidemiological studies example simulated population ages odds ratio menopause fifth compared first whereas reported using model structure substantial portion associations reported explained pharmacokinetics elsevier ltd rights reserved
aim present study compare response sub chronic application adulthood male female rats exposed drug spontaneous locomotor activity exploratory behavior adult male female rats exposed saline tested apparatus netherlands five consecutive days daily used challenge prior testing results showed rats exposed sensitive sub chronic administration adulthood exposed rats however effect prenatal exposure manifested differently males females contrast prenatal exposure decreased baseline locomotion females study indicates gender plays important role sensitivity prenatal development adulthood wiley periodicals inc
arthritis vitamin insufficiency prevalent older adults risk factors disability objective study examine effect arthritis vitamin deficiency upper lower extremity functional limitations disability older adults examined participants aged years subsample mexican health aging study measures included body mass index comorbid conditions falls physical activity physical function tests functional limitations activities daily living vitamin participants categorized four groups according arthritis vitamin status vitamin insufficiency arthritis vitamin insufficiency arthritis arthritis vitamin insufficiency fourteen percent reported arthritis vitamin insufficiency arthritis vitamin insufficiency group associated upper lower extremity functional limitations odds ratio confidence interval respectively disability compared vitamin insufficiency arthritis group reference group arthritis group three times likely report upper lower extremity functional limitations disability vitamin insufficiency group significantly associated functional limitations disability arthritis vitamin insufficiency increased risk disability population however effect arthritis vitamin insufficiency upper lower extremity functional limitations higher effect arthritis higher effect vitamin insufficiency alone
aim work check possibilities usage find relations members cattle relations animals important animals welfare influence animal health productivity early stage research relations animals determined base distance animals described like like like difficult precisely determine animals like distance also time direct behavior experiment carried dairy low energy attached regularly transmitted data smartphones distributed smartphones android system data sent relational database large amount data database data processed aggregated data transformed geometric form thanks specially developed application geometric data mapped relations written graph database graph databases useful tool analyse show relations animals technology used prepare graph database ict technologies used work sql server visual entity framework relational databases still analyse data graph databases especially useful visualize spatial relations objects new technologies allows perceptions create new possibilities getting knowledge lot tools connect requires multidisciplinary approach
investigated different types lies impact memory participants studied pictures objects later truth new objects multiple times describing seen forty eight hours later participants tested source memory results revealed participants good memory described never seen object relatively poor memory seeing studied object results suggest certain types lies make person likely addition repeated seen picture paradoxically increased false memories seen thus truth always prevent possibility memory distortion society applied research memory cognition published elsevier inc rights reserved
enteric enteric nervous system modulate regulated gut functions using molecular genetics assessed effects molecular entities expressed otherwise mediating two distinct mechanisms release dependent gut function expression mutated opposed gap activity increased gut motility vivo knock resulted reduction gut motility however inhibition dependent affect gut motility vivo rather increased fecal fluid content either expression dependent effect colonic motor complexes mainly decreasing frequency velocity contractions vivo thus differentially modulate gut using two distinct mechanisms
objective determine differences exist pharmacokinetics levonorgestrel based emergency contraception lng obese normal body mass index bmi users test whether dose lng obese women increases total free active lng serum concentrations study design healthy reproductive age women obese normal received lng orally subsequent menstrual cycle obese group also received lng dosing occurred follicular phase total free lng parameters obtained via serum samples catheter primary outcome difference total free lng concentration maximum obese group results total women enrolled completed study normal bmi median range obese bmi range total lng obese subjects following significantly lower level observed normal bmi women notably increased significantly level normal bmi subjects receiving free lng followed similar pattern conclusion obesity adversely impacts total free levels lng likely explains lack efficacy obese women dose appears correct obesity related changes additional research needed determine also improves effectiveness obese women implications study demonstrates obesity pharmacokinetics lng dose effective strategy improve efficacy obese women elsevier inc rights reserved
tone widely believed important physiological aspect emotion regulation associated positive behaviors however inconsistent evidence relations childrens baseline tone helpful prosocial responses others recent work adults suggests quadratic association inverted shape curve baseline tone present research examined whether nonlinear association evident children authors found consistent evidence quadratic relation tone across samples children using different measures compared low high tone moderate tone early childhood concurrently predicted greater self reported study observed empathic concern response distress others greater toward less peers study longitudinally predicted greater self mother teacher reported years later middle childhood study taken together findings suggest moderate tone rest represents physiological tendency engage different forms across different contexts early moderate tone reflect optimal balance regulation arousal helps prepare children comfort share others
state art progress structural engineering last years examined three areas spatial structural elements form assumptions constitutive materials form generalized stresses generalized strains relations computational implications solution strategy form closed form approximate numerical procedures structural level
including heterogeneous group terrestrial plants comprise species worldwide given various biological activities reported huge commercial potential due minute size rather small biomass various ecosystems seldom part rarely subject medicinal chemical analyses still hundreds novel natural products isolated shown contain numerous potentially useful natural products including lipids rare amino acids many specialized metabolites additionally different extracts isolated compounds shown antimicrobial antiviral cytotoxic effects smooth non muscles weight loss plant growth regulators activities also cause allergies contact dermatitis effects highlight potential source herbal production chemicals used various products
metabolic syndrome defines cluster interrelated risk factors cardiovascular disease diabetes mellitus factors include metabolic abnormalities hyperglycemia elevated triglyceride levels low high density lipoprotein cholesterol levels high blood pressure obesity mainly central adiposity context extracellular vesicles evs represent novel effectors help elucidate disease specific pathways metabolic disease indeed evs terminology encompasses apoptotic bodies emerging novel mean cell cell communication physiology pathology represent new way convey fundamental information cells microstructures contain proteins lipids genetic information able modify phenotype function target cells evs carry specific markers cell origin make possible monitoring fluctuations circulation potential biomarkers circulating levels increased metabolic syndrome patients mixed components evs content number evs derived distinct cells origin mode cell stimulation mechanisms production difficult attribute specific functions drivers biomarkers diseases review reports recent data evs different origins including endothelial smooth muscle cells macrophages hepatocytes adipocytes skeletal muscle finally microbiota message leading metabolic syndrome depicting complexity mechanisms involved functions reinforce hypothesis evs valid biomarkers represent targets innovative therapeutic approaches
last decade concerns veterinary students stress expressed several studies need student support become evident addition importance professional personal identity development veterinary curricula widely recognized need integrate academic professional skills instruction training personal life balance even though tools student support stress management exist within universities reports active creative practices veterinary education scarce report course organized twice optional part veterinary studies provide students tools everyday life personal development toward future veterinary career students defined learning objectives course reported received tools knowledge especially time management stress control course gave students opportunity step back schedules think lives actions even take concrete actions positive effect rich qualitative material collected pilot course used developing course also development mandatory curriculum
traffic surveillance become important topic intelligent transportation systems aimed monitoring managing traffic flow progress computer vision video based surveillance systems made great advances traffic surveillance however performance existing surveillance systems susceptible challenging complex traffic scenes object occlusion pose variation background moreover existing related research mainly single video sensor node addressing surveillance traffic road networks accordingly present review literature video based vehicle surveillance systems analyze existing challenges video based surveillance systems vehicle present general architecture video surveillance systems hierarchical networked vehicle surveillance survey different existing potential techniques different methods reviewed discussed respect module applications future developments discussed provide future needs services
paper effects shunt capacitor electrical network integrated renewable energy resources investigated proposes conduct hours load flow analyses ieee power system containing intermittent renewable sources modeled hourly generation profiles day using matlab program shunt capacitor connected selected load systems power factor changes evaluated day
human leukocyte antigens hla extensively studied antigen presenting receptors many aspects function remain elusive especially association various autoimmune diseases discuss illustrative case reciprocal relationship certain hla alleles two diseases rheumatoid arthritis vulgaris strongly associated hla alleles encode five amino acid sequence motif region beta chain called shared epitope associated hla allele encodes different sequence motif region interestingly hla confers susceptibility alleles encode sequence motif region beta chain protective currently convincing explanation effect present briefly review immunology diseases identify remaining gaps understanding association hla propose possibility beta epitope contribute disease risk mechanisms antigen presentation
phase sensitive detection circuit tests signals according correlation reference signal input signal noise eliminated independence reference signal noise signal sensitivity detector improved significantly suppression noise work phase sensitive detection circuit designed possesses characteristics low input noise variable output gain high sensitivity feasibility phase sensitive detection circuit verified signal noise ratio satisfactory
purpose study aims establish dynamic process model electromagnetic system predict temperature needle design methodology approach model used real time predicting static dynamic responses temperature therefore provide valuable analysis system monitoring findings electromagnetic process nonlinear problem system identification implemented neural network identifier simulate input output relationship real system excellent approximation ability uncertain nonlinear system system identifier analyzed selected recurrent neural networks models deal various treatment processes originality value neural network prediction model proposed study easy feasible method comparing two situations inputs fewer data trained present low mean squared error temperature response error appears within per cent advantages simple design stable efficacy useful establishing temperature prediction model ensure security
strategic problems electricity markets widely studied power systems often complex level optimization problems hard solve state art approach solve problems mixed integer linear programs however computational time grows dramatically network size increases scheduling horizon increases randomness taken consideration paper take fundamentally different approach propose effective customized convex programming tools solve strategic problem producers nodal electricity markets approach inspired theorem semi algebraic geometry several steps based upon convex optimization mixed integer programming results obtaining close optimal solutions evidenced several numerical case studies besides huge advantage reducing computation time computation time state art approach grows exponentially increase scheduling horizon number random scenarios computation time approach increases rather linearly
men testosterone levels decline per year age reduced androgen levels directly contribute lower urinary tract symptoms bladder dysfunction although mechanisms unclear study examined effect low testosterone testosterone replacement key mechanisms involved local bladder function release mediators atp response bladder measured whole rats weeks following whilst bladder assessed using isolated strips human cells cultured low physiological physiological testosterone conditions days induced release atp measured contractile activity bladder strips agonist induced nerve evoked contractions unaffected acetylcholinesterase inhibitor significantly increased amplitude activity bladder strips following prevented testosterone replacement release following bladder significantly reduced following whilst atp release unaffected contrast induced atp release cells significantly enhanced low testosterone conditions whilst release testosterone replacement physiological levels prevented changes whilst androgen deficiency weeks directly affect bladder smooth muscle mediator release sensitive changes testosterone changes mediator release early effect decline testosterone affect sensory pathways longer term contributing urinary symptoms bladder dysfunction seen androgen deficient men
current brain computer system used many applications technology also used capturing brain signals form eeg technique intensive applications non invasive technique signal capturing due temporal resolution low set cost easy portability compared techniques eeg technique dealing low frequency signals signals various noise urge designing implementing accurate stabilized system acquiring low frequency signals paper aiming design testing eeg acquisition system acquire brain signals initially low power high gain generalized operational amplifier designed later suitable filter designed eliminate noise signals produced low frequency operations order capture eeg signals generalized amplifier design system consists differential amplifier followed voltage follower circuit circuit designed using cadence tool facilitates capturing transient response generation virtual layouts every blocks system designed tested individually blocks virtual layouts generated transient response system contains eeg signals different voltage levels frequencies captured
native populations common conservation management approach aimed reducing threat extinction restoring ecosystem function born individuals sometimes used effectiveness strategy poorly understood due insufficient post monitoring evaluation objective evaluate utility using born individuals rodent key mouse population western end key state park released born mice march monitored population across sessions spanning years evaluated temporal changes microsatellite genetic diversity determine whether mice born wild derived released mice number mice declined individuals first weeks release increased estimated confidence interval individuals years genetic monitoring demonstrated slight decrease diversity first months increase year neighboring population detected year year corresponded largest increase population size trapping sessions change abundance corresponded possible role population growth resilience study demonstrates feasibility using born mice populations wild populations small serve donors translocation however gene flow expanding neighboring population affected growth persistence population study emphasizes future genetics monitored together demographic patterns gene flow affect interpret success
head neck constantly combination multidisciplinary advances article examines recent innovations affected field presenting research leading future advancement innovations include use virtual surgical planning three dimensional printing reconstruction advances intraoperative navigation imaging postoperative monitoring development minimally invasive techniques integration regenerative medicine stem cell biology reconstruction dramatic advancement face transplant
promising anti natural product however poor water solubility rapid serum clearance impose significant barriers delivery brain work aimed develop nanoparticle formulation extended circulation consequently increased brain uptake thus potentially efficacious treatment parkinsons disease spherical nanoparticles mean particle size prepared poly ethylene glycol block poly lactic acid nanoparticles nps encapsulation efficiency similar drug loading similar vitro release nps lasted sustained release pattern using canine kidney cell model results showed first intact nanoparticles carrying hydrophobic dyes internalized cells dyes slowly released within cells last nanoparticles free dyes side cell monolayer fluorescence resonance energy transfer imaging zebrafish suggested nanoparticles gradually vivo time nanoparticles maintained intact intestine brain post treatment nps orally rats much higher max auc observed plasma suspension furthermore brain delivery much effective nps suspension addition nps exerted strong neuroprotective effects zebrafish cell culture models protective effect partially mediated activation protein kinase akt glycogen synthase kinase beta beta pathway summary study provides evidence small sized nanoparticles improve cross barrier transportation oral bioavailability brain uptake bioactivity classification system class compound
ambient particulate matter known induce inflammation respiratory tract exposed subjects aim present study detect bronchial epithelial cells candidate inflammatory genes exhibiting transcriptional modifications following urban exposure paris urban sampled either background station winter summer tested comparison diesel exhaust particles human bronchial epithelial cells exposure gene profiling study performed using cdna cytokine expression array highlighted differential expression certain genes three selected genes interest alpha cytokine alpha chemokine ligand receptor increased expression confirmed pcr northern blotting bronchial epithelial cells culture medium particle treated cultures increased release alpha shown particle component responsible protein release varied two genes organic extract seemed mainly involved expression secretion whereas aqueous organic extracts induced alpha release conclusion bronchial epithelial cells paris increased mrna protein expression alpha involved process bronchial remodeling respectively
based dynamical modeling robust trajectory tracking control spherical mobile robot proposed spherical robot composed spherical three independent rotors act inner driver mechanism owing rolling without assumption robot subjected two constraints state space representation system developed using dynamical equations robots motion main contribution dynamical model based smc sliding mode controller designed position control robot parameters uncertainty dynamics decrease phenomena originated sign function known boundary layer technique imposed smc control gains determined using direct method way robustness zero convergence controllers tracking error guaranteed wide range computer simulations performed show significant tracking performance proposed smc particular parameters uncertainty white gaussian noises simulation results show significant performance designed nonlinear control system trajectory tracking control spherical robot even presence parameters uncertainty dynamics
host defined number distinct peers host network several algorithms proposed monitor network traffic identify high hosts centralized network operation center due massive amounts distributed data limitations transforming processing desirable design reversible data structures summarizing traffic measurements distributed network monitoring system data structure summarizes traffic measurements local monitor different monitors merged preserving error guarantee without increasing space reversible data structure report interested high hosts efficiently using compressed information without querying every single host network paper propose new data streaming algorithm identify high hosts network wide traffic measurements algorithm introduces new reversible data structure distributed network monitoring system designed noisy group testing theoretically analyzed algorithm evaluated real world data sets
incontinence associated dermatitis condition often encountered dermatologists inflammatory skin condition secondary prolonged urine urinary incontinence incontinence simply age related disorder rather due number pathologic conditions either reversible thus critical identify treat underlying causes urinary incontinence clinical management common medical issue patients lives also preventing future complications article aim provide dermatologists overview approach diagnosis initial management urinary incontinence
background children autism spectrum disorder asd often experience significant impairment however influence time pressure overall performance unclear aim current study characterise profile children asd across non conditions particular focus given spacing difficulties errors aim explore relationships intellectual motor skills different task conditions method boys asd matched controls aged years completed modified version speed performance test allowed ecologically valid relatively simple task participants simple cat dog five times condition results significant group differences identified errors spacing words either condition however asd group demonstrated greater variability relative controls particularly condition significant negative associations identified motor errors non condition conclusions motor processes shown significant role overall appears motor ability influence process different degrees depending nature task employed lack group differences respect errors spacing words suggest children asd ability compensate underlying motor impairment completing practiced writing task elsevier ltd rights reserved
collaborative applications energy low delay constraints emerging various networked embedded systems like wireless sensor networks multimedia terminals conventional energy aware task allocation schemes developed collaborative applications concentrated energy saving making allocation decisions consequently length schedules generated allocation schemes long unfavorable situations even tolerated remedy problem developed novel task allocation strategy called balanced energy aware task allocation collaborative applications running heterogeneous networked embedded systems algorithm aims blending energy delay efficiency scheme task thereby making best trade offs energy savings schedule lengths addition introduce concept energy adaptive window critical parameter strategy fine tuning size energy adaptive window users readily meet specific energy delay trade needs imposed applications furthermore built mathematical model energy consumption caused computation communication activities experimental results show significantly improves performance embedded systems terms energy saving schedule length existing allocation schemes
simulating nonlinear behavior complex systems requires significant computational effort despite rapid progress computing technology demand still strong efficient simulation methods diverse structural dynamics fields nonlinear system identification nonlinear system reliability addition efficiency algorithmic stability accuracy addressed development new simulation procedures paper method treat localized nonlinearities structure efficiently accurately proposed method stable system equations separated state invariant linear part state dependent nonlinear part considered external pseudo forces act linear system response system obtained fixed point iterations pseudo forces updated convergence addition one time step ahead prediction form novel idea multiple time step ahead prediction proposed effect approach investigated shown increase algorithm efficiency stability perform numerical integration time stepping schemes like exponential first order hold method used advantage efficiency accuracy increase accuracy stability method novel second order hold equivalent derived implemented efficiency stability accuracy method demonstrated numerical examples finally method applied earthquake induced motion story building local nonlinearities elsevier ltd rights reserved
background bipolar disorder disorder energy availability increased mania decreased depression accumulating evidence indicating increased mitochondrial respiration atp production bipolar mania contrasts decreased mitochondrial function patients depressive phase illness consequently central thesis paper bipolar disorder due dysregulation mitochondrial elements responsible dysregulation thus represent critical treatment targets mood disorders subject paper discussion many potential mediators mitochondrial function collectively implicated bipolar disorder levels oxidative stress pro inflammatory cytokines intracellular calcium ions higher bipolar mania depressive phases illness increased levels calcium ions partly account increased oxidative phosphorylation via documented pathways modulation elements atp synthase likewise increased levels oxidative stress pro inflammatory cytokines lead upregulation directly stimulate oxidative phosphorylation uric acid melatonin also differentially elevated bipolar mania molecules stimulate production atp pro apoptotic effects elevated glutamate dopamine bipolar mania higher basal levels activity bcl akt environment elevated uric acid decreased bdnf summary details pathways discussed explanatory model existence increased atp generation mania also offer model explaining nature mitochondrial respiration bipolar disorder transition mania depression based increasing levels tnf alpha ros together relationship kappa elsevier ltd rights reserved
background infections usually involved pathogenesis spondyloarthritis spa binding component innate immune system important role microbial study prevalence deficiency spa patients influence clinical profile studied spa patients healthy individuals paired age gender serum levels measured elisa test individuals levels considered deficient spa patients determination bath ankylosing spondylitis disease activity index basdai ankylosing spondylitis disease activity score crp bath ankylosing spondylitis functional index reactive protein crp erythrocyte sedimentation rate esr review clinical spa patients levels ranging median controls levels ranged median prevalence deficiency spa patients controls association correlation found levels basdai age disease onset crp esr crp presence peripheral arthritis spa subtype conclusion levels linked occurrence spa influence phenotype
past years major expansions public health insurance low income children united states medicaid childrens health insurance program chip state based efforts addition many low income parents gained medicaid coverage since affordable care act research date health insurance coverage among low income populations focused effect health care utilization health outcomes much less attention financial protection offers families review growing body evidence public health insurance provides important financial benefits low income families expansions public health insurance low income children adults associated reduced pocket medical spending increased financial stability improved material families also review potential poverty reducing effects public health insurance coverage pocket medical expenses taken account defining poverty rate medicaid plays significant role decreasing poverty many children families addition public health insurance programs connect families social supports food assistance programs also help reduce poverty conclude reviewing emerging evidence access public health insurance childhood long term effects health economic outcomes adulthood exposure medicaid chip childhood linked decreased mortality fewer chronic health conditions better educational attainment less reliance government support later life sum nations public health insurance programs many important short long term poverty reducing benefits low income families children
rare earth constitute enormous group compounds various structures properties group bonded metal several ways structural aspects coordination modes presented discussed statistical point view typical groups complexes reviewed data concerning thermodynamics formation mostly iii complexes aggregated briefly analyzed electronic spectroscopy mostly focused analysis transitions discussed simple systems elsevier rights reserved
frequent become serious problem urban areas world recent years necessary improve rainwater retention infiltration urban watershed purpose study report private rainwater retention harvesting tools facilities spread gradually steadily city smart way responding urban flood disaster risks rainwater harvesting tanks installed intensively rainwater harvesting house constructed city japan city experienced flood disaster former enhanced users daily emergency latter inspired construction rainwater harvesting housing complex adjacent city elementary school construction november another nearby inspired facilities school located land old irrigation pond thus school needs adapted condition rainwater retained within school water used toilet water grown pupils amounts retention discharge monitored data utilized science education big cities people tend depend much top system involving rivers strengthening drainage systems constructing flood walls etc man made surfaces urban areas bottom individual collaborative approaches adopted order achieve multiple purposes preventing mitigating disasters preserving ecosystems communities city authors published elsevier ltd
paper describes use methodology value stream mapping analysis manufacturing engineering new product introduction processes applicability usefulness technique process improvement domain explored case study production system new component part planned proven analysis enables improvement strategy manufacturing engineering process successfully outlined
intelligent smart environments usually developed indoor applications like ambient assisted independent living persons homes users intelligent support various human activities also outdoor spaces forests elsewhere open nature extensive usage wireless sensor networks combined cloud based services possible wearable equipment seems usable efficient purpose paper vision intelligent knowledge rich outdoor environment illustrated example knowledge rich outdoor environment sea among others based exploitation sophisticated wireless sensor networks sending data appropriate cloud mobile access necessary information
research suggests approach withdrawal subject parenting influences studies explored specific parenting behaviors contextual novelty contribute observed pattern effects present study examined associations infant approach mother behavior introducing novel objects months approach withdrawal months sample infants males maternal positive affect predicted approach withdrawal high approach infants maternal stimulation predicted less approach withdrawal low approach infants however patterns varied intensity novelty parenting outcome contexts thus maternal behavior lead stronger associations earlier later measures approach withdrawal however effects tied contexts measurement elsevier inc rights reserved
organizations information security levels information security become essential element business management however excessive focus mere reinforcement information security placed employees stress studies confirmed negative effects stress include reduced employee productivity therefore important manage employee stress information security organization based person environment fit theory study examines employees become stressed factors behind information security stress differences managerial technical security oriented organizations results show work overload invasion privacy information security stressors furthermore work overload greater effect managerial security oriented organizations invasion privacy exerts greater influence technical security oriented organizations addition attitude compliance information security policy work overload invasion privacy findings used basic reference establishment employee stress management measures evaluation information security stress levels elsevier ltd rights reserved
predictions human metabolism needed interpretation biological monitoring data frequently made animal studies consequently assumptions made relationship absorbed dose metabolite excretion results two human volunteer studies highlight problems associated animal studies way shows markedly different metabolite patterns administered orally man following dermal dosing ratio trans cis acids approximately compared oral administration ratio total acids acids also differs depending route dermal oral knowledge human metabolism two routes enables much meaningful interpretation biological monitoring measurements forms conjugate major urinary metabolite rat volunteers low dose levels metabolite present insignificant levels much abundant metabolite shows extrapolation species misleading concluded benefits using human volunteers metabolism studies low doses far minimal risks involved basis biological monitoring studies lead greatly improved risk assessment pesticides use
system identification structures one important aspects structural health monitoring accuracy efficiency identification results affected severely measurement noises especially structure system large bridge structures online system identification required paper least square estimation method used combined approach identifying structural parameters cable stay bridge large degree online numerical analysis carried first dividing bridge structure smaller estimates parameters online using method simulation results demonstrate proposed approach capable identifying structural parameters however accuracy efficiency identification results depend highly noise sensitivities loading region loading pattern element size
objective rare disease pathology background coronary artery rare cause myocardial infarction cases association prosthetic mechanical valves reported report case myocardial infarction caused left coagulation profile patient critical stenosis case report year old woman taken lab early coronary intervention non elevation myocardial infarction showed atrial fibrillation controlled ventricular rate coronary angiography showed total occlusion mid left anterior artery upstream treatment apparent passing wire abnormalities seen ultrasound study echocardiography revealed critical stenosis left atrial mild left ventricular dysfunction coagulation profile revealed sub therapeutic international normalized ratio levels sequential images normal ultrasound study presence atrial fibrillation confirmatory coronary embolism cause myocardial infarction anticoagulation treatment acute coronary syndrome initiated referred closed conclusions coronary artery thromboembolism cause acute coronary syndrome rare treatment consists aggressive anticoagulation antiplatelet therapy interventional options including simple possible context primary prevention form patient education optimal anticoagulation oral vitamin antagonist medical advice thromboembolic risks extreme importance
paper presents new converter switched reluctance motor controlling speed using soft computing technique like fuzzy logic controller operating modes proposed converter circuit discussed proposed converter capable minimizing torque ripple faster excitation nature also improving average torque compared conventional converter circuit fuzzy logic controller becoming important methodology control engineering fast response easily modified cheaper implement require mathematical modeling perfect speed tracking peak overshoot compared conventional controller objective paper achieve desired speed response effective controller effectiveness proposed system verified using simulation simulation results carried using matlab simulink corresponding results presented
objectives aim study determine whether presence depression associated increased likelihood hospital admission among adult patients years diagnosed head neck cancer visiting emergency departments eds united states background head neck cancer associated high morbidity mortality patients cancer depression predictive increased mortality effect remains adjusting comorbidities patients cancer depressed less likely participate treatment decisions seek social support lead worsening overall health outcomes among patients materials methods performed secondary analysis data nationwide emergency department sample united states using multivariable poisson regression estimate prevalence ratios confidence intervals cis included adults aged years older diagnosed using international classification diseases revision icd codes controlled demographic clinical hospital characteristics multivariable models results final multivariable model adults years male patients depression likely admitted following visit female patients depression likely admitted stratified analysis association strongest males specific oral cavity likely admitted conclusion depression associated hospital admission among adults aged
healthcare professionals regularly face requests parents predictive genetic testing children adult onset conditions little known handle test requests given guidelines recommend testing adulthood unless medical benefit testing time study explored process decision making parents semi structured interviews conducted regional genetic services across data thematically analysed found instead yes requests many framed consultation opportunity negotiate optimal time testing argued facilitates parents considered decision making since parents eventual decisions test often testing child cases parents requests remained sustained wish said agree test testing serve childs wider best interest strategy determining childs best interest facilitating shared decision making recommend frame requests testing parents discussion optimal time testing adult onset disease
cross cultural study examines first whether month olds helping behavior differs cultures second way caregivers socialization goals practices associated toddlers helping behavior helping behavior assessed three reach tasks increasing motivational demands found toddlers helped toddlers regarding socialization practices mothers compared mothers reported provide opportunities help family context less fostering toddlers prosocial behavior furthermore mothers reported use practices children follow helping request intra cultural level found helping positively associated practices sample whereas helping negatively related practices providing opportunities help basis results first propose culture affects toddlers helping behavior time emergence second year second propose culture specific conceptions prosocial behavior influence parents use turn influence childrens motivation underlying early prosocial behavior
background developed evaluated feasibility peptide nucleic acid based fluorescence melting curve analysis detect common mutations myeloproliferative neoplasms mpns methods set two separate reactions based calr set mpl calr set clinical usefulness validated allele specific real time pcr fragment analysis sanger sequencing bcr negative mpns results limit detection based approximately mutation interference reactions using mixtures different mutations observed non specific amplification observed normal control based able detect calr three six mpl mutations detected except three samples low mutant concentration exon mutations negative without influencing results among six variant calr exon mutations two detected method owing probe binding site conclusions based detecting common mpl calr mutations rapid simple sensitive technique bcr negative mpns mutant allele time initial diagnosis elsevier rights reserved
composed cell cell communication complicated signaling cascades regulate pollen tube growth guidance toward double fertilization critical successful sexual reproduction exploring expression profiles vivo grown pollen tubes important nevertheless difficult obtain accessible pollen tubes profiling studies model plants taking advantage styles vivo pollen tubes harvested styles cut open used study protein transcript profiles quantitatively qualitatively altered total protein composition pollen tubes generated amplified total rnas vivo grown vitro cultured pollen tubes used suppression hybridization analyses preparation home made array chips microarray analyses conducted different probe sets revealed transcripts specifically present enriched vivo pollen tubes reverse transcription pcr pcr situ hybridization northern blotting applied validate unique induced expression features interestingly several transcripts simultaneously detected transmitting tract epidermis vivo pollen tubes tightly deduced amino acid sequences showed encoded small proteins classified several families transient assay revealed like structures proteins one probably localized generative cell small peptides critical pollen tube growth exploration biological functions mechanisms action great interest
simple determination acid offers possibility follow individual deviations metabolism one carbon two carbon units take part endogenous synthesis three groups young men levels urine followed application given food supplement daily doses first group men found level increased independently day time application second group men level increased within interval application dropped normal level third group men days study effects compared vitamin vitamin given evening day morning day increased excretion men four men independently application elsevier ltd rights reserved
aim test hypothesis stimulates differentiation mitogen activated protein kinase mapk core binding factor pathway methods activation mapk detected western blotting alkaline phosphatase alp activity calcium deposition assessed differentiation bone marrow derived mesenchymal stem cell cultures expression analyzed mrna protein levels activity detected electrophoretic mobility shift assay bone alp osteocalcin gene transcription also evaluated either pcr northern blotting results mol dose dependently led rapid sustained activation mapk pathway mouse cultures treatment mol resulted increased alp activity calcium deposition cultures function time also enhanced dna binding activity promoted expressions several regulated genes including alp concurrent treatment mapk inhibitor diminished induced maturation mapk activation mouse cultures conclusion results indicated stimulate differentiation cultures mapk pathway
paper conduct theoretical research contemporary architecture engineering construction management optimization approach background green architecture recent years concept green environmental protection becoming thorough popular feeling also makes green building arises historic moment become focal point construction projects present stage however process green building design especially design management existed many problems defects needs green building management strictly follow environmental protection design concept strictly quality pass paper comprehensive analysis green building design management order provide reference paradigm development
practice effective exhaust waste heat recovery heat exchanger exhibit high heat transfer performance reasonable pressure drop achieve high net power output therefore complete numerical thermoelectric generator model used engine exhaust gas heat recovery presented paper based common plate type exhaust heat exchanger model considered temperature gradient along fluid flow direction also included fluid heat transfer flow resistance characteristics interaction relationships exchanger scales heat transfer flow resistance characteristics thermoelectric performance mainly studied study numerical simulations using program results show high power achieved small cross section area corresponding small optimal module area small height required cross section area constant obtain maximum net power fluid flow resistance optimal cross section area optimal scales height length applied automotive vehicle exchanger scales available wide optimal design range help achieve high net power output scale optimization match met elsevier ltd rights reserved
college construction management programs across nation integrating building information modelling bim curricula various forms specific priorities nevertheless common goal competent workforce possesses desired knowledge skills abilities industry largely bim study explores project based learning four year undergraduate curriculum special focus bim implementation sustainable design construction joint course project study examines improve critical student learning outcomes pertaining institutional assessment program requirements specifically students two upper division elective courses ongoing campus project real project teams major project included developing leadership energy environmental design leed certification strategy bim project execution plan performing design conducting performance simulation leed credit compliance documenting project information leed assessments conducted joint course experience enhancing students understanding working knowledge bim implementation sustainability domain joint course project also provided instructors opportunities align course program standards paper outlines strategies implementing managing joint course project shares various metrics tools adopted project evaluation results findings joint course project expected light competency based program assessment future bim curriculum innovation
expressions derived three cases expectation uncertainty body burdens doses calculated linear model environmental transport human metabolism terms expectation uncertainty inputs discrete stochastic random variables three cases compared determine relationship expectations uncertainties varying assumptions constant input case input selected randomly simulation period distribution population exposed held constant throughout two time varying cases random autoregressive assumed discrete stochastic exposures input made partially correlated respectively exposure constant time interval length expectation values body burdens doses constant input case identical random case autoregressive cases stationary inputs uncertainties body burdens doses constant input case identical limit rapid metabolism random case autoregressive cases stationary inputs limit slow metabolism uncertainties body burdens doses constant input case respectively greater random case alpha alpha alpha alpha respectively greater autoregressive case stationary inputs coefficient alpha increasing number sampling periods decreases uncertainty increasing increases uncertainty example application ingestion island weak form slow rapid metabolism limits apply give result uncertainty body burden constant input case times greater random case alpha uncertainty body burden autoregressive case times greater random case smooth transition autoregressive case random case constant input case shown alpha increases random constant
background patients failed traditional treatment chronic urticaria require trials alternative medications safety profiles continuous laboratory monitoring physician comfort often barriers treatment objectives evaluate safety alternative agents used chronic urticaria methods retrospective chart review electronic medical records single center allergy immunology clinic major academic hospital conducted one hundred twenty six charts patients chronic urticaria treated alternative agents reviewed results adverse effects reported patients patients patients patients patients patients patients adverse effects mild require discontinuation medication resolved stopping medication decreasing dose conclusions use alternative agents treatment chronic urticaria angioedema generally safe proper laboratory clinical monitoring observed american academy allergy asthma immunology
extensive diagnostic therapeutic interventions particularly problematic dangerous diabetic patients metabolic cardiovascular renal neurological psychiatric thromboembolic complications uncommon additionally cases inadequate preoperative metabolic adjustment perioperative complications wound healing disorders general infections possible necessary early hospital discharge insufficient training physicians nursing personnel complex disease financial pressures inadequate preoperative preparation patients elective interventions essential reasons average frequency perioperative postoperative complications diabetic patients care adults disease discussed preoperative period discharge detailed recommendations given perioperative management drugs
sustainable construction construction method beginning gain traction among contractors dearth research knowledge socialization strategic support field many obstacles towards adoption applied effectively become part strategic method concept sustainable construction primarily emphasizes wise use resources primarily natural resources thereby systematically guaranteeing future needs however use recycled materials still hampered difficulty field implementation low scores attained green building certification study analyze strategies needed support sustainable construction relation supply chain management materials implemented whereas highest impact contributing effectiveness sustainable construction aim study analyze supply chain performance materials construction projects measurement used supply chain operations reference model perfect order overall value risk key performance indicator result study percentage material used management supply chain fulfilled perfect order use material complete support sustainable construction authors published elsevier ltd
mechanics urine transport renal bladder great interest knowledge different physical variables physiologic movements pathologies help better diagnosis treatment objective chapter show physics principles relevant basic relations urine transport bring clinical world explain movement urine obstruction explanation based two tools used theoretical analysis theory continuous media mechanics computational simulation offers practical solution scenario moreover review contributions field physical simulation additive manufacturing techniques finally list current limitations tools technological development lines future projection conclusions chapter aim help understand important concepts promoting multidisciplinary cooperation offer complementary tools help diagnosis treatment diseases
shift operator finite difference time domain method developed study stealth technology inhomogeneous plasma paper high accuracy efficiency method verified computing reflection transmission coefficients electromagnetic wave plasma one dimension stealth effect radar targets covered epstein distribution inhomogeneous plasma studied results show stealth effect radar targets covered epstein distribution inhomogeneous plasma better radar targets covered homogeneous plasma elsevier gmbh rights reserved
increased brain volume consistent finding young children autism spectrum disorders asd however regional specificity developmental course abnormal brain structure less clear small sample sizes particularly among voxel based morphometry investigations likely contribute difficulty recently established large scale neuroimaging data repositories helped clarify neuropsychiatric disorders schizophrenia prove useful asd structural brain images autism brain imaging database exchange contains participants analyzing using investigate total brain tissue volumes regional brain structure abnormalities asd two overlapping cohorts analyzed subjects cohort included individuals usable mri data matched samples cohort comprised asd individuals matched within site age sex total brain grey matter volumes enlarged approximately asd however effect reached statistical significance subjects cohort within subjects cohort analysis revealed enlargement left anterior superior temporal gyrus asd significant regional changes detected matched samples cohort non significant reduction correlation asd compared brain structure abnormalities asd individuals age older consists subtle increase total brain volume due enlargement grey matter little evidence specific effects
complete nucleotide sequence gene assembled full length genome sequence presented turkey isolates gene encoded two open reading frames translated two products latter produced via translation predicted processed non structure proteins missing analysis revealed identity similarity avian infectious virus amino acid level whole genome consists nucleotides nucleotides excluding poly tail total predicted five rnas detected infected turkey small northern blotting whole genome sequence identity supporting group elsevier rights reserved
cascade air source heat pump water suitable provide high temperature water wide range outdoor air temperature previous studies focused operating characteristics cascade heat pump system performance improvement selection optimal immediate temperature however reported studies control strategies cascade heat pump identified paper proposed control strategy cascade air source heat pump water adjust load variation principle two stage compression ratio approximately used determine intermediate pressure intermediate pressure degree temperature regulated compressor electronic expansion valves fan low temperature cycle respectively proportion integration differentiation pid controller proportional controller control strategy experimentally tested wide operational range cascade air source heat pump water results showed controller developed successfully helped realize control intermediate pressure temperature terms control accuracy sensitivity elsevier ltd rights reserved
purpose review asthma due cleaning products known years interest topic still large number cleaning workers respiratory problems review sought highlight recent findings relationship exposure cleaning products asthma summarize specific literature published recent findings women confirmed workers exposed cleaning products higher frequency men work related respiratory symptoms diseases many cases asthma due cleaning products occur healthcare increased risk asthma shown related number years job early life disadvantage recent evidence suggests predisposition adult onset asthma related interaction genes occupational exposure low molecular weight agents evidence mechanism common although several case reports showed mechanism amine compounds summary review updated recent findings epidemiology cleaning agents mechanism prevention asthma due cleaning agents article provides new information level exposure still high professional even domestic frequency asthma professional domestic mechanism common although immunological mechanism possible especially healthcare workers exposed
adsorption properties metallic ions essential human metabolism cadmium lead silica chemically modified phosphate investigated using batch systems immobilization procedure efficient degree mol mol results indicate phosphate reacted ratio equilibrium reached quickly min indicating sites exposed best adsorption parameters evaluated using aqueous phase adsorption time min adsorbent adsorption obtained metals ions distribution coefficients affinity metal ions studied increases order twice much lead surface mol cadmium mol capacity greater nevertheless adsorption plateau observed academic press
spin logic devices provide promising based alternative boolean logic implementations post complementary metal oxide semiconductor cmos era principle logic functionality implemented practice performance gate significantly affected layout choices implications adequately explored past article proposes systematic approach building standard cells basic building block overall design methodology implementing large based circuits first propose new technique reduce magnet count majority gate still ensure correct functioning layout optimization methods building physics based analysis build standard cell library diverse functionality characterize library delay energy area perform delay optimized technology mapping benchmark circuits using library approach results circuits faster consume less energy area efficient compared standard cell library incorporate layout based optimization techniques work
paper analyse state art regarding sports injuries sport psychology perspective first section introduce concept definition important variables levels causes types four models explain relationship factors vulnerability level injury presented table second section called historical evolution spain make record main research lines different authors groups field sport psychology spain finally third section papers included introduced contribution first
article analyzes association civil conflicts educational achievement studying turkish case combines university entrance exam scores million students newly constructed data set turkish conflict study association conflict educational achievement turkish students results reveal significant negative association combined already established positive links education various measures socioeconomic development like economic growth social equality public health results article demonstrate education one channels civil conflicts damage societies thereby creating conditions
paper presents initial findings ongoing research effort focused identifying quantifying ranking essential industry practices successful delivery faster fast track flash track projects research data collection involves literature search engineering procurement construction industry interviews discussions industry expert panel research extensively explored analyzed international practices deeply explored project execution practices industries construction including manufacturing software engineering development methodology employed research entails deployment three round delphi process analytic hierarchy process produce comprehensive list prioritized recommendations essential flash track practices paper contributes body knowledge identifying ranking industry best practices essential successfully manage unique challenges risks inherent flash track projects research finds planning execution organizational practices essential considerations successful flash tracking also highlights central role relationships fully integrated work teams extends earlier studies calling innovative approaches prevailing practices new paradigm flash track projects american society civil engineers
juvenile idiopathic arthritis common chronic rheumatic disease unknown aetiology childhood predominantly presents peripheral arthritis disease divided several subgroups according demographic characteristics clinical features treatment modalities disease prognosis systemic juvenile idiopathic arthritis one frequent disease subtypes characterized recurrent fever rash juvenile idiopathic arthritis common among young female patients usually accompanied anti nuclear positivity anterior seropositive juvenile idiopathic arthritis analogue adult rheumatoid arthritis seen less paediatric patients juvenile idiopathic arthritis entity specific childhood appears widespread large small joint involvement enthesitis related arthritis separate disease subtype characterized enthesitis asymmetric lower extremity arthritis disease subtype represents childhood form adult human leukocyte antigen positivity commonly without axial skeleton involvement juvenile psoriatic arthritis characterized psoriatic rash accompanied arthritis nail disease complications vary growth retardation osteoporosis secondary treatment disease activity life threatening macrophage activation syndrome multi organ insufficiency advent new therapeutics past years marked improvement juvenile idiopathic arthritis treatment long term outcome without sequelae treatment juvenile idiopathic arthritis patients involves teamwork including experienced paediatric paediatric primary goals treatment eliminate active disease normalize joint function preserve normal growth prevent long term joint damage timely aggressive treatment important provide early disease control first line treatment includes disease modifying anti rheumatic drugs methotrexate combination corticosteroids used different dosages routes oral intravenous intra articular application steroids seems effective treatment modality especially biological agents added treatment patients anti tumour necrosis factor agents etanercept infliximab adalimumab anti interleukin agents agents cell regulatory agents shown safe effective childhood patients recent studies reported sustained reduction joint damage even complete clinical improvement paediatric patients compared previous data
species class attracting international attention owing wide variety biological activities great potential ingredient skin care cosmetics including skin products however little information available inhibitory effect activity therefore objectives study investigate chemical composition inhibitory effects isolated active compound using ethanol extraction ethyl acetate addition assayed inhibitory effects activity biosynthesis melanoma cells study identified bioactive compound inhibits activity expression cellular expression related protein associated transcription factor thereby decreasing production furthermore also affected mitogen activated protein kinase mapk cascade cyclic adenosine camp dependent signaling pathway involved melanoma cells finding exerts inhibitory effect contribute use preparation skin care products future
paper presents perception sensor network detect audio based emergency situations human consists multiple units pan tilt camera audio signals acquired array used sound source classification sound source localization order work multi person scenarios propose audio visual fusion method detect single speaking person among multiple ones system demonstrated scenario four persons system able detect localize person send robot location check condition
several options emergency contraception available united states article describes method including efficacy mode action safety side effect profile availability effective emergency contraceptive copper intrauterine device iud followed ulipristal acetate levonorgestrel pills levonorgestrel available without restrictions whereas ulipristal acetate available prescription copper iud inserted clinician although pills shown reduce pregnancy abortion rates population level important option individual women seeking prevent pregnancy sex
background widely used improve symptoms patients functional multiple large scale clinical studies reports drugs mechanism action aim study assess effects gastric gastric gastrointestinal symptoms health related quality life qol placebo controlled study methods conducted randomized double blind placebo controlled study fifty japanese patients randomly assigned either placebo day weeks baseline weeks treatment evaluated patients gastric motility using determine values gastrointestinal symptom rating scale qol anxiety depression scale results four patients failed complete medication regimen analysis data placebo patients patients analyzed significantly increased gastric compared placebo respectively significantly accelerated gastric half time significantly improved total scores compared placebo qol differ significantly two groups significantly improved anxiety score compared placebo conclusions placebo controlled study demonstrated significantly increased gastric gastric japanese patients also improved patients symptoms anxiety score
installation wireless sensor networks power becoming unavoidable developing smart electrical network high voltage equipment power produce impulsive noise happens much wireless communications conventional white noise indeed choice physical layer communication network easy fits evaluate advantages bound different technologies communication deploying network electromagnetic environment characterized tests performed order estimate communication performances paper presents investigation ieee ghz system performance high voltage use recorded data measurement campaign identify models noise obtained modeled class process recent model using several statistical tests evaluated two models first results show class accurate modeling partial discharges electricity model accurate model impulsive noise high voltage compare class gaussian models addition performances ghz layer studied environment results show impulsive noise influence close gaussian noise noise according snr
year old male admitted sustained fever months liver dysfunction anti igm antibody positive elevated epstein barr virus ebv dna load peripheral blood liver biopsy revealed infiltration positive ebv positive cells peripheral blood mononuclear cells pbmcs also positive showed detectable levels ebv dna monoclonal proliferation ebv infected cells detected pbmcs southern blotting ebv terminal repeat ebv although ebv positive cell disease ebv suspected symptoms spontaneously resolved within months anti igm antibody clonal band ebv negative year onset anti antibody positive final diagnosis thus confirmed infectious results indicate ebv infected positive cells clonal proliferation ebv infected cells temporally detected ebv carefully excluded cases
study intelligent energy efficient outdoor lighting control system developed used green buildings intelligent building functions contribute reduction carbon dioxide emissions using conservation electric energy daylight efficiently intelligent energy efficient lighting control system based expert system one artificial intelligence techniques four functions running real time first function controlling monitoring lamp groups functions fault diagnosis power lines connected lamp groups load estimation lamp groups expert system written two separate computer microcontroller based environments using knowledge based rules rule base real time control monitoring function contains rules education semester operation mode real time control monitoring function implemented average conservation achieved energy consumption system first expert system application expert system used control monitor outdoor lighting perform load estimate fault diagnosis elsevier rights reserved
extracting critical sections project management documents challenging process active area research project management documents contain certain modelled properly inform project planners managers advance risks via early extraction indicators documents termed text mining active area research context construction project management extraction semantically crucial information documents challenging task turn used provide decision support entire project lifecycle research presents two step modelling clustering methodology exploits capability bayes classifier extract early management text data first step database corpus prepared via qualitative analysis fed questionnaire responses latter stage naive bayes classifier proposed evaluates real world construction management documents identify potential risks based certain keyword classifier outcome compared labelled test documents gave accuracy better majority text mining algorithms reported literature
relation activity occurrence cardiac arrhythmias still topic intensive investigation strictly related enhanced complex structure cardiac tissue characterized multi sized electrophysiological spatial however structure function tissue sometimes also promote phenomena spontaneous termination waves role played tissue scenario understood yet investigation study implemented formulation phase action potential model ischemic conditions investigate size ischemic tissue conduction properties affect system dynamics drive towards maintenance activity main findings show stability waves changes conductivity intracellular space critical alterations extracellular space maintenance self termination strongly dependent size also degree intracellular anisotropy findings confirm extend results obtained previous investigations addition since experimental values conductivity reported literature consistent overview possible scenarios arising broader range assumed anisotropy values provided relation different sizes ischemic perspective simulations shown compare impact different degrees tissue anisotropy wave dynamics authors published elsevier
sustainability become major concern construction industry growing emphasis green buildings last decade critical terms improving energy efficiency building stock paper green building certification process existing buildings developing countries investigated qualitative case study methodology employed gain better understanding critical success factors certification process respect six leadership energy environmental design leed certified projects turkey examined framework used analyze components process including drivers resources green implementations barriers benefits impacts approved materials poor design buildings difficulties documentation process major barriers barriers overcome commitment owners top management support collaborative working among project parties findings study expected guide construction professionals existing buildings effective manner similar studies conducted existing buildings different countries different regulations conditions exist proposed framework also employed investigate certification process new construction projects american society civil engineers
study system two parabolic nonlinear reaction diffusion equations subject boundary condition system nonlinear equations used mathematical modeling biosensors integral type boundary condition links solution system boundary integral solution within system inner range integral plays important role boundary condition general formulation boundary value problem solution boundary points calculated using integral combined proportional integral derivative controller algorithm mathematical model applied modeling control drug delivery systems converted active form enzyme containing delivering body linear exponential stepwise protocols drug delivery investigated corresponding mathematical models delivery created
purpose aim study investigate attitudes three european countries italy one thousand forty eight students recruited italian university centers methods socio demographic questionnaire scale administered staff results cross cultural significant differences among italian students found scale italy mean mean mean analysis sociodemographic characteristics revealed male gender emerged main predictor attitude three countries although also conservative political orientation religious belief predict higher levels italy particularly conclusions study revealed european countries assessed attitudes toward different display higher levels confirming central role cultural differences attitudes nevertheless socio demographic aspects identification male similar influence attitudes assessed populations
human hair valuable contributor biological monitoring information storage point assess effects environmental nutritional occupational sources body human proteins amino acids compounds among key components find sources different effects disorders human body sulfur significant one compounds great affinity metals compounds property sulfur affects human health positively negatively manuscript sulfur determined hair samples autistic age match control group children via molecular absorption using high resolution continuum source graphite atomic absorption spectrometer purpose hair samples appropriately dried degrees samples dissolved microwave digestion using sulfur determination extraction performed incubation degrees total protein albumin determination validity method sulfur determination tested using hair standard reference materials results uncertainty limits certified values confidence level finally correlation sulfur levels autistic childrens hair total protein albumin levels done elsevier rights reserved
order meet requirement high sensitivity signal noise ratios snr study develops optimizes pressure sensor using double silicon sensing element first ansys finite element method voltage noise models adopted optimize sensor size sensor output sensitivity voltage noise snr result sensor released double times sensitivity single sensor consistent experimental result result also displays sensitivity snr closely related geometry parameters doping concentration achieve high performance type implantation geometry long cross area thick required proposed pressure sensor fabricated using standard complementary metal oxide semiconductor cmos process wet release process pressure sensor produces change voltage output external pressure applied involved experimental results show pressure sensor high sensitivity range kpa nevertheless performance pressure sensor influenced temperature drift finally obtaining accurate complete information wide temperature pressure ranges data fusion technique proposed based back propagation neural network improved particle swarm optimization pso algorithm particle swarm optimization back propagation pso model implemented hardware using bit microcontroller results calibration test experiments clearly prove pso neural network effectively applied minimize sensor errors derived temperature drift
article describes new approach studying collaborative memory examines peoples editing processes naturally occurring memory errors approach memories individuals combined via method participant indirectly receives information previous participant participants asked individually study word lists recall many words possible online setting participant completed recall task answers provided next participant suggested answers recall however participant allowed add words provided list suggested answers final answer group aggregate recalled words based answer given last participant chain results showed participants displayed high accuracy recall throughout chain although able replicate entire study list eliminate errors end chain procedure advantage allows examination memory editing processes individuals communicate information indirectly independent social factors arise face face group memory settings
study various coatings including stabilized films deposited substrate using suppress thermal aging tests microstructure growth films observed using scanning electron atomic force thermal aging behavior coated various films investigated accelerated experiment weight loss decreased thickness coatings increasing among films film suppress effectively compared material degradation thermoelectric properties coated samples decreased slowly accelerated thermal aging test
recently skin detection employed applications computer vision including face detection gesture recognition etc mainly due appealing characteristics skin color potency segment objects however certain challenges involved utilizing human feature detect faces led many methods order counteract factors paper skin segmentation method exploits multi step diffusion algorithm detect skin regions presented method starts conservative extraction skin seeds frame accomplished using fusion ternary based human motion detection modified bayesian classifier feedback mechanism subsequently candidate skin pixels utilized stage diffusion scheme detect skin pixels quantitative qualitative results demonstrate effectiveness proposed system comparison works
single phase induction motors used industry commonly induction motors expensive reason use diagnostics faults important prevents financial loss unplanned causes faults paper authors described fault diagnostic techniques single phase induction motor presented techniques based analysis thermal images electric motor authors measured analysed states single phase induction motor paper original method feature extraction thermal images called method area selection states presented proposed method image histogram used form feature vectors classification obtained vectors performed nearest classifier gaussian mixture models described fault diagnostic techniques useful reliability single phase induction motors rotating electrical machines three phase induction motors synchronous motors motors elsevier ltd rights reserved
role system nicotine addiction increasingly acknowledged acute inhibition degradation efficiently reduces nicotine withdrawal induced affective symptoms rats fatty acid hydrolase degradation enzyme proposed possible treatment nicotine addiction however unclear whether chronic inhibition nicotine abstinence beneficial deleterious affective side effects using rat model nicotine addiction found abstinence rats injected daily inhibitor developed depressive like phenotype results show nicotine rats induced low consumption persistent immobility forced swim test increased levels response stress addition receptor binding activity key structure control nicotine related emotional states contrast non treated rats showed increased receptor activity behaviors comparable controls inhibition induced alterations observed animals previous history saline self administration taken together results suggest chronic inhibition prevents homeostatic adaptations receptor function necessary recovery nicotine dependence elsevier ltd rights reserved
schizophrenia associated severe cognitive deficits including impaired working memory neural contribute disruption excitation inhibition balance cortical remains unknown however alterations map onto behavioral deficits patients based predictions validated model spatial hypothesized two key behavioral consequences increased variability time reducing performance precision decreased ability filter predictions studied schizophrenia patients matched healthy comparison subjects hcs performed designed test computational model specifically manipulated delay duration distance presented delay subjects used high sensitivity indicate remembered location yielding continuous response measure results largely predictions whereby patients exhibited increased variance less precision delay period increased relative hcs schizophrenia patients also exhibited reports biased toward specific spatial locations predicted model finally magnitude drift significantly correlated indicating possibly shared underlying mechanism effects consistent elevated ratio schizophrenia establishing framework translating neural circuit computational model cognition human experiments explicitly testing mechanistic behavioral hypotheses cellular level neural deficits patients published elsevier
new deterministic model hiv aids incorporates pre exposure prophylaxis designed used assess population level impact use transmission dynamics disease within msm population conditions effective control elimination persistence hiv aids msm population determined rigorously analyzing model uncertainty sensitivity analysis carried using data relevant hiv transmission dynamics msm community state determine effect uncertainties parameter values outcome response variable associated reproduction number identify parameters effect disease transmission dynamics numerical simulations show current rate administration antiretroviral treatment hiv infected individuals hiv burden decreases increasing coverage furthermore setting study suggests hiv effectively controlled msm population addition current rate administration anti therapy community least mean susceptible members msm community adjusted efficacy elsevier inc rights reserved
dual education effective integration control theory practical experience providing ideal start improve professional career students many technical universities important benefits brings students industrial partners practical training industry companies opportunity acquire practical skills modern industrial plants production equipment feel employed learn requirements culture companies time students great chance offered job still studies paper presents modern form study focus development control methods control structures ict applications different types industrial processes since emergence late become established academic subject now researched taught large number worldwide universities research institutions try get heart multidisciplinary engineering excellent example point integration disciplines leads new degrees freedom corresponding dual form education connection industrial partners ifac international federation automatic control hosting elsevier ltd rights reserved
permanent community based housing supportive services supported housing numerous favorable outcomes homeless experienced consumers little known however consumers attain subsequently lose supported housing using mixed methods compared persons retained supported housing least year lost supported housing within year move among persons housed supported housing program greater los homeless registry data identify reviewed medical records randomly selected compare demographics era service income presence absence serious mental illness health service utilization subsample selected semistructured qualitative interviews detailed medical record review also performed qualitative interviews focus groups staff leadership recursive partitioning identified quantitative variables best differentiated thematic analyses performed qualitative data interrelated factors associated supported housing chronic low intrinsic motivation unmet needs mental health care substance abuse treatment independent living skills poor primary care engagement frequent emergency department use recent mental health hospitalizations findings suggest value clinical interventions address factors example motivational interviewing social skills training adapted setting context supported housing
laser heating technology type potential attractive space heat flux simulation technology characterized high heating rate controlled spatial intensity distribution rapid response however controlled plant nonlinear time varying uncertainty implementing laser based heat flux simulation paper novel intelligent adaptive controller based proportion integration differentiation pid type fuzzy logic proposed improve performance laser based ground thermal test temperature range thermal cycles many instances order improve adaptability controller output scaling factors real time adjusted thermal test underway initial values scaling factors optimized using stochastic hybrid particle swarm optimization pso algorithm validating system established laboratory performance proposed controller evaluated extensive experiments different operating conditions reference load disturbance results show proposed adaptive controller performs remarkably better compared conventional pid pid controller conventional pid type fuzzy pid controller considering performance indicators overshoot settling time steady state error laser based ground thermal test reliable tool effective temperature control laser based ground thermal test chinese society production hosting elsevier ltd open access article license
understanding spatial temporal characteristics water flux shallow imperative water resources management eco environmental conservation study spatial variability vertical specific fluxes hydraulic evaluated integrating distributed temperature sensing data vertical hydraulic gradients ensemble kalman filter empirical thermal mixing model formulation assimilation scheme based discretized conduction equation heat transfer first systematically tested synthetic case performed quantitative statistical analyses evaluate performance assimilation schemes real world case evaluated calculate specific flux initial estimate spatial distributions vertical hydraulic gradients obtained empirical thermal mixing model steady state conditions using constant vertical hydraulic conductivity initial estimate updated repeatedly dividing specific flux estimates vertical hydraulic gradients obtain refined spatial distribution vertical hydraulic gradients vertical hydraulic results indicate optimal parameters derived fewer iterations greater simulation effort using compared field application stream segment river basin northwest china average vertical hydraulic varied three orders magnitude specific fluxes ranged near zero vertical hydraulic gradients within range highest variable fluxes occurred adjacent debris dam bridge phenomenon likely result heterogeneous hydraulic characteristics areas results significant implications micro habitats fish incubation regional flow solute transport models river basin similar hydrologic settings
article propose novel framework modelling non stationary multivariate lattice processes approach extends locally stationary wavelet paradigm multivariate two dimensional setting framework develop permits estimation spatially spectrum within channel interest importantly cross covariance describes coherence channels associated estimation theory also established demonstrates multivariate spatial framework properly defined suitable convergence properties also demonstrate model based approach successfully used classify range colour provided industrial yielding superior results compared current state art statistical image processing methods
canada faces environmental problems threaten stock natural capital natural resources water forests land atmosphere flow goods services natural capital generates known ecosystem services much literature focuses climate change greenhouse gas emissions many challenges persist including air water pollution risks oil gas extraction water scarcity flooding loss natural areas threatened species toxic regulatory responses exist effectiveness relatively little use market based instruments focus challenges associated measuring developing policy sustain natural capital ecosystem services highlight problems identify policy options big ideas help improve understanding linkages natural capital ecosystem services human achieve sustainable future
post recently argued less inevitable end assume private accumulation systematically blocked inability create setting prices lose control reproduction process labour eventually drawing case study amazon thoughts policies leading digital challenge assumptions key corporate players trying become powerful partly using network effects scaling opportunities digital goods building socio technical ecosystems strategies led development part structures hence creating situation market competition draw basic assumptions capital theory argue situation labour process becomes key competitive strategies see expansion digital control organizational structures applied key corporate players digital economy evidence expansion labour reduction
minimal mass ultra lightweight high packaging efficiency volume important factors associated space technology hence become attractive traits getting larger bandwidth satellites orbit nowadays maintaining surface shape pre tension membranes instrument precision become challenging problem hence membrane receiving increasing attention mission architectures need extremely large space antennas paper presents finite element investigation rectangular flat thin membrane using actuated material actuator sensor passive effect dynamics space based rectangular shaped structure studied trends natural frequencies various patch areas thickness explored investigation shows rather using various numbers patches practical system controlling vibration behavior single patch appropriate thickness easily control desired vibration behavior therefore concluded discrete sensor actuators devices preferred realize lower weight effective control authority modest values actuator voltages active vibration control practical structures
paper presents weakly coupled formulation electromagnetic thermal fields applying backward differentiation formula theta algorithm adaptive time stepping variable order finite element discretization coupling electromagnetic diffusion equation electrical circuit equations also included minimum time step criterion adopted algorithm time step size order selection implemented proposed model programmed language example presented show application formulation
paper studies stochastic behavior signed variants algorithm system identification framework input signal white gaussian process three algorithms studied signed signed error sign sign algorithms input signal modeled white gaussian random process periodically time varying power system parameters vary according random walk mathematical models derived mean mean square deviation behavior adaptive weights input models used derive new results concerning performance algorithms results surprising monte carlo simulations three algorithms provide strong support theory
paper complete sensitivity analysis optimal parameters axial flux permanent magnet synchronous machines working field region implemented thanks presence parameterized accurate analytical model possible obtain required parameters machine two goals ideal design maximize power density density ratio maximal rated speed max inductance related parameter keeping efficiency target speed different poles phases combinations studied reveal optimum combination phase paper studied effect ratio number stator number rotor poles density max shown low value parameter results better density max effect outer diameter inner outer diameter ratio studied respect two design goals addition comparison finite theoretical infinite speed designs implemented complete finite element validation proven robustness analytical model
patients philadelphia negative chronic myeloproliferative neoplasms mpns anti thrombotic treatment follow affect evaluation pro thrombotic weight clinical biological characteristics diagnosis order avoid potential confounding effect investigated relationship prior thrombosis thrombosis occurred diagnosis treatment characteristics diagnosis patients mpn according criteria occurred patients similar rates different mpns multivariate analysis rate significantly related minor higher mutation older age cardiovascular risk factors highest rate associated coexistence minor note inverse relationship rate platelet count consistent paradox conclusion analysis mpn patients disclosed unbiased characteristics diagnosis pro thrombotic effect moreover suggests optimal control blood cells counts utmost importance prevention thrombosis follow elsevier ltd rights reserved
aim spinal trauma one important causes trauma related morbidity worldwide spinal injuries often caused traffic accidents falls sports injuries injuries aim study stress incidence injury mechanism spinal types spinal province retrospectively reviewing patients material method patients applied emergency department clinic education research hospital spinal trauma traffic accidents classified vehicle vehicle accidents falls classified according height follows falls heights height result patients admitted due falls height patients admitted due falls patients admitted due vehicle traffic accidents patients admitted due vehicle traffic accidents patients admitted due sports injuries one patient admitted due assault thirty one patients underwent surgery due neurological deficit radiological instability fifty eight patients managed conservative approach one patient died pre operative period discussion aim study indicate incidence spinal trauma mechanism injury types spinal trauma province epidemiological study
novel alloy nanoparticles nps two dimensional photocatalysts successfully synthesized via mild wet chemical process facile deposition procedure composite photocatalysts characterized ray diffraction xrd scanning electron microscopy sem transmission electronic microscope tem ray photoelectron spectroscopy xps vis diffuse reflection spectroscopy electron spin resonance esr surface spectroscopy showed highest photocatalytic activity degradation visible light lamp coupled cutoff filter lambda photocatalytic efficiency improved times compared pure respectively novel composites make way synthesize semiconductor composites potential applications solar energy conversion environmental elsevier rights reserved
increasing demands functional temporal requirements software electric motor controllers demand solutions efficient time space usage providing required functionality embedded software electric motor control deal control operation protection supervision safety user interfaces concerning need embedded software architecture combines concept function state based code proposed compared standard implementation based proposed solution function partitioned several shorter one active given state system thus reducing management overhead
paper describes experimental investigation load settlement behaviour model strip resting reinforced homogeneous sand bed several depths medium dense dense states sand reinforcement single layer woven geotextile layer without ends depth base width particular focus study effect ends reinforcement load bearing capacity experimental results study compared numerical findings finite element analysis carried using software study shows significant improvement load bearing capacity stiffness sand bed increasing depth provision ends reinforcement numerical results follow experimental results closely lower settlement values results presented graphical form paper used general guidelines practical conditions similar considered present study
aims objective study examine effect cultured murine melanoma cells antioxidant potentials primary human keratinocyte cells main methods anti effect performed via determination content activity antioxidant potentials assessed cellular antioxidant assays respectively key findings reduced inhibiting activity cells dose manner eventual investigated evaluating capacity induce dna degradation treated cell nuclei detected different tested concentrations ability protect cell dna hydrogen peroxide oxidative effect cells investigated using assay appears solution suppressed induced addition molecule revealed significant cellular antioxidant capacity reactive oxygen species formation cells significance thus introduced natural skin agent skin care products elsevier inc rights reserved
various intelligent disposition algorithms used allocate mobility requests electric vehicles however none incorporate issue site energy generation company running mixed work presents approach distribute mixed conventional internal combustion engine vehicles battery electric vehicles coordination decentralized energy management economic target parameters maximized includes detailed charging schedule new algorithm based mixed integer linear program developed incorporates variable charging infrastructures mobility profile company different vehicle classes produce optimized usage schedule company main findings new developed model capable analyzing financial ecological potential individual provides customized recommendation optimal composition depending number specification vehicles authors published elsevier
area around known exploration petroleum deposits reservoirs less permeable whereas surface characterized units hosting important springs area used drinking water supplies therefore vulnerable monitored protected adequately early late evening construction exploitation drilling fluids lost unknown void two days later water flowing spring lying lower normally used domestic water supply drinking bulk chemical analyses carried water shown composition similar drilling fluids lost confirming hydrological connection estimations indicate first signs drilling fluids took flow injection point spring corresponding mean velocity similar spring developed underground drainage system also confirmed marked flow rate changes measured spring ranging base flow around flood peaks reflecting source nature initial contamination pollution lasted just days water returned acceptable drinking water standards relatively quickly however pollution related heavy mineral continues registered flooding spring normally high turbidity values pollution event offers example hydrocarbon exploitation areas natural springs provide domestic water supplies controlled effectively prevent disasters occurring pollution incident also useful example accidental tracer tests identify rapid flow paths long distances elsevier rights reserved
background multiple sclerosis patients faced complex risk benefit profiles disease modifying drugs making treatment decisions effective shared decision making patients understand risks benefits make treatment decisions based personal preferences methods inclusive systematic review primarily assess current understanding patients information provided standard healthcare system secondary aim assesses patients preferences specific risks benefits treatments systematic search conducted using pubmed embase google scholar total studies reviewed across aims relevant quantitative qualitative data extracted two authors narrative synthesis conducted due heterogeneity research findings results trend risks generally underestimated benefits generally overestimated patients treatments potentially offer substantial symptom improvement delay disease progression reduction relapses preferred even expense higher risks conclusions many patients experience information standard healthcare system provide satisfactory understanding risks benefits effective ways communicate risk benefit information making shared treatment decisions needs identified patient preferences risks benefits also taken account elsevier rights reserved
paper presents high speed drive used electrically assisted charging internal combustion engine system enhance performance reduce dynamic drawbacks affect conventional solutions lag however design electric drive presents challenges especially related thermally aggressive environment high rotational speed therefore system level design approach needs adopted different sub systems drive addressed simultaneously thus paper includes considerations thermal electromagnetic machine design furthermore voltage source inverter featuring wide sic power devices described rotor position detection digital control used drive machine finally test setup preliminary experimental results presented
experimental epidemiological evidence suggests consumption carbohydrate grain important risk factor common cause mortality unknown whether small intestinal capacity absorb limiting even adapt increased carbohydrate load investigated changes border membrane carbohydrate digestive enzymes glucose capacity small intestine response increased expression glucose transporter assessed western blotting immunohistochemistry northern blotting qpcr dependent glucose transport glucose transport rates protein mrna expression fold higher fold higher maintained enriched diet compared activity diet controlled study determined expression biopsies switched gradually month period low day high day diets known composition show expression enhanced time fold fold study important implications dietary management
aim aim current study collect clinical normative data clinical impairment assessment questionnaire eating disorder examination questionnaire adult patients eating disorders eds study also examined unique contributions eating disorder symptoms levels related sample patients females males recruited six specialist centres across norway majority sample diagnosed eating disorder otherwise specified bulimia nervosa diagnosed anorexia nervosa results significant differences global scores females males female sample significant differences found several sub scales group group significant differences found diagnostic groups male sample significant differences found diagnostic groups multiple regression analysis revealed variance impairment measured accounted body mass index eating concern shape weight concern binge eating served significant unique predictors impairment results present study contribute interpretation scores samples
attempting educate practitioners computer security difficult reason breadth knowledge required today security profession includes widely diverse including cryptography network architectures programming programming languages design coding practices software testing pattern recognition economic analysis even human psychology individual choose one narrow elements pressing need practitioners solid understanding principles whole created network simulation tool used instruction network security course graduate students tool created three specific purposes first provides simulation sufficiently powerful permit rigorous study desired principles simultaneously reducing eliminating unnecessary complexities second permitted students rapidly prototype suite security protocols mechanisms finally equal students able develop attacks protocols created based observations student reviews believe three features combine create powerful pedagogical tool provides students significant amount breadth intense emotional connection computer security single semester
grain abundant stress however features induced secretion organic acid potential genes responsible secretion poorly understood induced secretion grain roots characterized ion enzymology methods suppression hybridization together quantitative real time pcr qrt pcr used identify regulated genes potentially involved secretion results showed grain roots citrate response stress secretion pattern however differs citrate neither chloride cadmium chloride induced secretion total genes identified regulated six genes considered potentially involved secretion expression pattern gene belonging multidrug toxic compound family close agreement citrate secretion expression gene encoding transporter four genes encoding atp binding cassette transporters differentially regulated stress expression pattern correlated secretion results reveal secretion pattern citrate grain roots stress also provide genetic information useful characterization genes involved toxicity tolerance mechanisms
aim study explore differences boys girls diagnosis clinical phenotypes autism spectrum disorder asd chinas children diagnosed asd females retrospectively included analysis children assessed using autism diagnostic interview revised autism diagnostic observation schedule results showed girls scored significantly higher socio emotional boys also scored lower restricted repetitive behaviors meanwhile proportions girls satisfied diagnostic cut scores domain lower boys results indicated girls asd show greater socio emotional boys girls also tended show fewer boys type girls differ boys found less sensitive girls particularly assessment domain
small molecule probes suitable selective specific fluorescence imaging important low concentration intracellular reactive sulfur species cysteine pose challenge chemical biology readily available fast response fluorescence probe hydroxyl phenyl group functional moiety enables high selectivity high sensitivity detecting solution biological system specifically reacted probe undergoes seven released excited state photon transfer effect highly fluorescent insoluble aggregate formed facilitate high sensitivity high resolution imaging results showed probe remarkably large stokes shift detect physiological condition interference analytes moreover probe proved excellent chemical stability low cytotoxicity good cell permeability design probe provides novel potential tool visualize localize cysteine live cells greatly help explore various related physiological pathological cellular processes cell biology diagnostics
recent research demonstrated participants prefer complete larger series responses exchange longer duration access rather completing fewer tasks associated smaller frequent access review provides summary line research examines variables contributing participant preference performance different response arrangements discusses limitations areas future research
ingredients usually kept special box used exclusively reflects life value community especially traditional codes conduct obvious plays important role everyday life however time passes importance now confined traditional events activities used visit observe proposal engagement study identifies examines role nonverbal communication marriage community study conducted finding shown used seen symbol opening conversation symbol asking symbol accepting symbol symbol unity placed front items used made wood used interior holds small covered boxes little cylindrical container placed according furthermore community believe something bad occur followed addition seen sign educate community importance following rules engagement plays seen symbol live together also promises engagement tie promise man woman get married
background establishment consistent routine activities occur right often recommended part healthy sleep habits however studies investigated dose dependent association routine sleep outcomes especially young children particularly recommended thus aim study examine associations consistent routine sleep outcomes young children ages large global sample assess whether dose dependent relationship frequency routine concurrently retrospectively sleep outcomes participants mothers children australia new zealand canada china hong kong india japan korea malaysia singapore thailand united kingdom united states completed brief infant child sleep questionnaire results consistent routine associated better sleep outcomes including earlier shorter sleep onset latency reduced night increased sleep duration decreased parent perceived sleep problems daytime behavior problems also related institution regular routine furthermore dose dependent relationship better outcomes associated increased doses routine currently retrospectively found within predominantly asian predominantly caucasian cultural regions conclusions results indicate regular routine associated improved sleep young children suggests consistently routine younger started better
present paper approximation applied study light scattering large soft particles special attention cylindrical photosynthetic micro organisms approximation similar anomalous diffraction approximation includes description phase functions resulting formulations radiative properties multidimensional numerical resolution requires close attention argued strong benefits expected statistical resolution monte carlo method designing efficient monte carlo algorithms requires development non standard algorithmic using careful mathematical analysis integral formulations codes develop make available include original treatment nonlinearity differential scattering cross section squared modulus scattering amplitude thanks double sampling procedure approach makes possible take advantage recent methodological advances field monte carlo methods illustrated estimation sensitivities parameters comparison reference solutions provided matrix method presented whenever possible required geometric calculations closely similar used standard monte carlo codes geometric optics computer graphics community calculation rays surfaces opens interesting perspectives treatment particles complex shapes elsevier ltd rights reserved
water footprint developed within water resources research community volumetric measure freshwater concept used assess water use along supply chains sustainability water use within river basins efficiency water use water allocation dependency water supply chain purpose integrating life cycle assessment products lca scholars proposed weight original volumetric water scarcity catchment located thus obtaining water scarcity weighted reflects potential local environmental impact water consumption paper provides elaborate proposal main points counting water use differently based level local water scarcity actual debate water scarcity water resources competing uses depletion global scale neglect green water consumption fact green water scarce since water scarcity catchment increases growing overall water consumption catchment multiplication water use specific process activity water scarcity implies resultant weighted process activity affected processes activities purpose environmental performance indicator lca treatment inconsistent environmental defined water stress index cited water scarcity metric lca community lacks meaningful physical interpretation proposed incorporate topic freshwater scarcity lca natural resource depletion category considering depletion global perspective since global freshwater demand growing global freshwater availability limited key measure comparative claim different products limited accessible usable freshwater flows author published elsevier ltd
paper presents method solving known verbal arithmetic using microsoft along solver add order make suitable classroom presentation elements method introduced first linear program integer linear program finally integer linear program different variables unlike approaches discussed literature force method logic programming parallel genetic algorithms method require knowledge computer programming also introduces users often neglected integer constraints increase computational time associated constraints
purpose investigate effectiveness gradient boosting classify versus lymphoma cytokine levels method patient diagnoses aqueous levels interleukin retrospectively extracted national eye institute histopathology core database compared post hoc tests gradient boosted decision tree classifier trained differentiate versus lymphoma aqueous data sets tested train test split fold cross validation training set results seven lymphoma patients included higher aqueous lymphoma aqueous significantly higher lymphoma aqueous three fold cross validation demonstrated predictive accuracy aqueous data sets upon validation testing set aqueous data sets achieved predictive accuracy data achieved predictive accuracy sensitivity specificity area receiver operating characteristic curve roc auc conclusions limited sample size gradient boosting differentiate lymphoma high sensitivity specificity however larger cohort needed validation
background historically inpatient protocols adopted relatively conservative approaches anorexia nervosa order reduce risk syndrome potentially fatal symptoms however increasing evidence suggests patients tolerate higher caloric prescriptions treatment result prevention initial weight loss shorter hospital less exposure effects severe malnutrition therefore present study sought examine effectiveness accelerated protocol inpatient atypical sample methods participants youth ages atypical hospitalized medical stabilization retrospective chart review conducted assess changes weight status percentage median bmi indicators syndrome specifically hospitalization weight assessed approximately weeks discharge results cases syndrome observed though participants evidenced treatment levels monitored participants prescribed supplemental time discharge higher rates caloric changes predictive greater changes hospitalization rates caloric weight change related increased likelihood admission conclusions results suggest accelerated approach inpatient youth atypical safely implemented associated syndrome provided close monitoring correction findings suggest approach potential decrease length stay burden associated inpatient hospitalization supporting continued progress hospitalization
appraisal research traditionally focused negative emotions addressed issues concerning relationships several positive emotions daily life extent occurrence positive emotions explained overlap driven priori hypotheses appraisal emotion relationships study investigated positive emotions appraisal dimensions using ecological assessment results provide strong evidence positive emotions correlate significantly daily life importantly found positive emotions overlap theoretically relevant compared irrelevant stronger predictive occurrence furthermore appraisal overlap theoretically relevant predicted occurrence positive emotions even appraisal excluded indicating positive emotions occur just virtue shared valence findings refined appraisal profiles positive emotions underscore importance accounting differences among positive emotions
background asthma disproportionately affects minority populations associated psychosocial stress racial ethnic discrimination aimed examine association perceived discrimination asthma poor asthma control african american latino youth methods included african american mexican american latino youth aged years genes environments latino americans study study african americans asthma genes environments asthma defined physician diagnosis asthma control defined based national heart lung blood institute guidelines perceived racial ethnic discrimination assessed experiences discrimination questionnaire focus school medical public settings examined associations perceived discrimination outcome whether socioeconomic status ses global african modified associations results african american children reporting discrimination greater odds experiencing asthma reporting discrimination similarly african american children faced increased odds poor asthma control experience discrimination counterparts reporting discrimination associations observed among latino children observed heterogeneity association reports discrimination asthma according ses reports discrimination increasing odds asthma among low ses mexican american youth interaction among high ses latino youth interaction conclusions perceived discrimination associated increased odds asthma poorer control among african american youth ses effect perceived discrimination asthma among mexican american latino youth
clinical animal model studies implicated inflammation peripheral immune cell responses pathophysiology alzheimers disease peripheral immune cells including cells cerebrospinal fluid csf healthy adults found brains patients rodent models blocking entry peripheral macrophages cns reported increase amyloid burden mouse model assess inflammation mouse model first quantified central immune cell profiles deep cervical lymph nodes spleen brains mice activated high high myeloid derived immune cells decreased cells increased function age relative non mice immunological changes along evidence increased mrna levels several cytokines suggest immune regulation trafficking patterns altered mice levels soluble tumor necrosis factor modulate blood brain barrier permeability increased csf brain post mortem subjects mice report vivo peripheral administration novel biologic inactive reduced age dependent increase activated immune cells mice decreasing overall number cells addition treatment vivo rescued impaired long term measured brain slices association decreased plaques selective targeting modulate brain immune cell infiltration prevent delay neuronal dysfunction significance statement immune cells cytokines perform specialized functions inside outside brain maintain optimal brain health extent activities change response neuronal dysfunction degeneration understood findings indicate reduced age dependent increase activated immune cells mice decreasing overall number cells addition impaired long term rescued association decreased hippocampal plaques selective targeting holds translational potential modulate brain immune cell infiltration neuroinflammation prevent delay neuronal dysfunction elsevier inc rights reserved
phenomena associated free stream turbulence boundary layer flows relevant number subjects believed continuous spectra equations describe process thus used specify inlet condition simulation bypass transition however continuous spectra equations free stream disturbances journal fluid mechanics pointed continuous spectra exhibit several non physical features due non parallelism proposed large reynolds number asymptotic approach showed non parallelism leading order effect even short wavelength disturbance response concentrates edge layer paper asymptotic solution verified numerically studying evolution incompressible boundary layers found numerical results accurately predicted asymptotic solution implying latter adequate moderate reynolds numbers introducing series solutions inflow perturbations bypass transition investigated via direct numerical simulation transition processes including evolution amplification secondary instability modes emergence turbulent spots agree experimental observations
paper introduce real time face recognition system targeted blind low vision people system uses microsoft sensor wearable device performs face detection uses temporal coherence along simple biometric procedure generate sound associated identified person estimated location approach uses variation nearest neighbors algorithm histogram oriented gradient descriptors reduced principal component analysis results show approach average outperforms traditional face recognition methods requiring much less computational resources memory processing power battery life compared existing techniques literature suitable wearable hardware constraints also show performance system dark using depth information acquired infrared camera validation uses new dataset available videos people containing variation illumination background movement patterns experiments existing datasets literature also considered finally conducted user experience evaluations visually impaired users showing encouraging results
good evidence gender specific differences asthma regarding affected areas intra extracellular mediators whole organ structure functioning lung result complex parts synergistic parts opposing effects especially female sex hormones rather asthma protective effects male hormones include effects cellular immune system additionally gender differences sociocultural origin regarding presentation doctors diagnosis treatment asthma symptoms undertaken coping strategies concerning female male patients complaints taking account gender specific differences asthma contribute improved individual diagnosis therapies
study focuses evolving integrated water management plan city summer capital british india presently state capital total water demand million per day system capacity present deficit amplify resource assessment related watersheds namely accomplished using remote sensing techniques geographic information system gis based arc hydrological model average annual precipitation watersheds years flows runoff groundwater watersheds water balance equation considered validation criteria coefficient correlation observed rainfall simulated runoff varies results validated actual measurement inflow lean period one major sources river shown good correlation simulated observed stream flow study establishes existing sources sustainable suggests source augmentation coupled rainwater harvesting reuse wastewater long term strategic measures
original prospective cohort study conducted attempt significantly reduce incidence severity injuries intervention cohort compared two season historical cohort provide recommendations international federation football pertaining prevention measures make game safer total male mean age years female mean age years players participated study four prevention measures implemented pocket rule self fitting mouth ankle players recurrent ankle sprains injury treatment information time loss injuries sustained game sessions recorded field medical personnel followed detailed phone injury surveillance questionnaire reduction total number injuries significant reduction incidence rate incidence proportion intervention cohorts compared historical cohort statistically significant reduction number injuries body parts except hand wrist injuries related use severity mild moderate injuries study provided evidence hand wrist injuries significantly reduced football recommendations include strict enforcement pocket rule use soft comfortable fitting ankle mouth additionally change game rules concerning blocking
leptin derived cytokine secreted mostly adipose tissue serum leptin levels elevated obese individuals correlate positively body mass index bmi interestingly serum leptin levels also elevated patients psoriasis correlate positively disease severity psoriasis associated obesity patients psoriasis higher incidence obesity obese individuals higher risk developing psoriasis additionally obese patients psoriasis experience severe degree psoriasis study hypothesised leptin link psoriasis obesity plays role psoriasis investigate role psoriasis applied widely accepted induced psoriasis like skin inflammation mouse model leptin deficient mice evaluated psoriasis severity moreover stimulated human keratinocytes leptin investigated effect proliferation expression pro inflammatory proteins mice clinical signs infiltration scales dorsal skin inflammation ear skin measured ear thickness attenuated compared mice moreover mrna expression levels increased epidermal thickness significantly less induced vitro effect leptin stimulation human keratinocytes demonstrated increased proliferation induced secretion several pro inflammatory proteins two hallmarks psoriasis conclusion leptin deficiency attenuated induced psoriasis like skin inflammation mouse model leptin stimulation induced pro inflammatory phenotype human keratinocytes thus supporting role leptin psoriasis
self injury prominent individuals borderline personality disorder bpd abundant evidence affect regulation plays important role majority patients affective variability core feature bpd thus hypothesize affect stabilization function bpd affect stabilization process individuals attempt make affect stable reducing affective variability tested hypothesis participants bpd reported affect using valence activation activation dimension experience sampling study random signals scheduled per day days results indicated individuals engaged show within subject variance valence activation individuals engage however within patients individuals engaged frequently study showed less variance valence activation patients engaged less frequently suggests reinforced affect stabilization function discussion explore alternative explanations relation affective variability consider clinical implications elsevier ltd rights reserved
inhibitors effectively lymphocyte activation proliferation shown effective disease control certain autoimmune disorders preventing allograft rejection kidney transplantation whether immunomodulatory agents useful control autoimmune allograft acceptance avoiding need additional strong shown report first case year old man affected serious debilitating form psoriatic arthritis presented course third high immunological risk kidney transplantation three years transplantation patient benefited switching based therapy without additional immunosuppression showing complete regression symptoms progression severe radiological lesions recovery disability functional impairment remarkably treatment association steroids also provided stable normal allograft function time abrogated development novo circulating donor specific years follow case report describes successful clinical radiological response severe form psoriatic arthritis conversion highly sensitized kidney transplant patient
objective relationship education usually conceived relationship enhancement currently satisfied couples goal helping couples sustain satisfaction however also useful brief indicated intervention couples low satisfaction current study evaluated effect couples low high relationship satisfaction method study randomized controlled trial couples randomly assigned book reading control condition control relate online assessment feedback relationship goal setting relate relate flexible delivery skill based education program couples assessed relationship satisfaction individual mental health year follow results couples high initial satisfaction showed effects satisfaction relate increased satisfaction couples low initial satisfaction effects months effects mental health conclusion flexible delivery produces immediate effects indicated early intervention couples low relationship satisfaction effects attenuate future research needs seek methods produce better maintained effects
characterized isolates reduced susceptibility spp five escherichia coli one one one one pseudomonas aeruginosa hospital different genes identified polymerase chain reaction sequencing bacterial strain typing performed enzymatic pulsed field gel electrophoresis typing sequence typing selected isolates majority one isolate genes two contained genes typing showed presence nine different clones belonging eight sequence types molecular characterization remaining isolates confirmed presence one producing coli clone five isolates one clone isolates furthermore identified aeruginosa isolate permanent introduction producing clones hospital repeated occurrence one producing one producing coli clone period year concern requires intensified investigations
elementary strength materials core undergraduate engineering course introduces mechanics bodies traditionally focus course analysis course apply analysis design order better prepare students become engineers design primary function practicing engineers semester long design project implemented provide opportunity students practice design student teams design equipment including conceptual layout material selection load specification design analysis cost estimate final report web site created facilitate administration project provide links data sources give design analysis examples paper summarizes design project tools created ease time burden associated project focus assessment effectiveness project results assessment three state positive analysis data indicates students completed course design emphasis better skilled design perform equally analysis relative students completing traditional strength materials course
support accountability group trained supervised volunteers support sex core member circle aim supporting core members transitions toward full prospective multi method design used explore psychological social transitions core members data collected start circle months months qualitative data collected semi structured interviews core members total professionals analyzed computer assisted program qualitative data analysis quantitative data assessed self report questionnaires sex offenders mean differences tested repeated measures qualitative results indicated improvements reflective skills openness problem solving skills social skills agency self regulation quantitative results documented improvements emotion regulation internal locus control positive trends self esteem coping skills due small sample size results interpreted caution core members professionals reported unique contribution process claim needs confirmation
printing combination printing technology smart materials provides potential actuation devices paper used deposition modelling printing technology fabricate double layer smart material activated temperature directly electric circuit indirectly double layer mathematical model developed describe bending behaviour caused mismatch strain surface layer basal layer deformation performed find different bending rules low cost printed active composite different physical states considerable maximal deformation values deformation force carbon fibre acid specimens ether specimens paper provide double layer smart material printing method prospective applied sensors actuators transducers artificial muscles
purpose healthcare projects face multiple obstacles achieving sustainability paper aims provide information regarding energy consumption healthcare facilities identify barriers sustainability suggest methods improve effectiveness buildings design methodology approach study investigates sustainability healthcare buildings examining national databases energy use energy savings authors initiate dialogue topic interviewing experts healthcare planning design regarding implications data challenges sustainability potential solutions challenges findings analysis data energy information administration revealed healthcare facilities rank second among building types usa energy use per square foot rank fourth total energy use data green building council showed per cent healthcare buildings registered leadership energy environmental design rating system per cent achieved certification low compared building types research limitations implications research discussion continue engaging stakeholders interpret data identify solutions facilitate sustainable healthcare design construction operation practical implications important approach sustainability healthcare social economic environmental health related perspectives authors identify five major barriers sustainable healthcare design construction discuss practical solutions originality value given energy demands healthcare buildings facilitating sustainability potential make significant difference national energy use empirical research evidence based design potentially help accelerate sustainability impacts documenting economic operational returns investment
fusarium infection severe fungal infection caused fungi genus fusarium commonly occurs immunocompromised patients malignant hematological comorbidities secondary hematopoietic stem cell transplant classical route contamination inhalation infection also occur skin lesion report describes case year old woman developed graft host disease days receiving allogeneic stem cell transplant donor hodgkin disease day transplant patient presented fever several painful subcutaneous red nodules ulcerative features pelvic region right leg extensive glass lesions lungs however patient following skin biopsy culture cutaneous lesions computed tomography scanning lungs scanning magnetic resonance imaging facial patient diagnosed disseminated fusarium species infection despite intensive treatment patient respiratory insufficiency day transplant case noteworthy patient additional risk associated allogeneic transplant transplant mismatch severe neutropenia prior clinical signs association skin lesions lesions increased initial immunosuppression delayed diagnosis
aim characterize formation urinary elimination metabolites humans methods subject six session double blind placebo controlled balanced crossover design study formation metabolites para amp determined urine intravenous doses placebo parent drug metabolite levels urine plasma measured gas chromatography mass spectrometry pharmacokinetic parameters calculated models using results approximately difference elimination observed amp dose converted amp amp furthermore less excreted urine compared correspondingly excretion less conclusions metabolism formation amp highest selectivity greater percentage converted amp formation less affected administered suggesting urine stable biomarker metabolism
widely used chinese medicine helps relieve asthma allergies however underlying mechanisms remain unclear particular mechanism affecting dendritic cells dcs play critical role immune response remains unknown study examine effects extract major compound functions results showed significantly inhibited activation maturation approximately respectively cell proliferation contact hypersensitivity responses inhibited mice either demonstrated first time major active ingredient exhibited significant immunosuppressive effect functions revealing functional food ameliorate chronic inflammation autoimmunity published elsevier ltd
recent studies shown patients eating disorder deficits neuropsychological functioning cognitive remediation therapy developed improve cognitive deficits objective study apply group adolescents eating disorder whose age ranged central coherence cognitive flexibility analyzed means complex figure test making test clinical measures ten weekly minute sessions designed results study indicated outstanding improve central coherence patients eating disorder research needed evaluate efficacy clinical population future research incorporate randomized controlled trials control groups use perspective
seasonal changes photoperiod influence body weight metabolism mice examined effect changes photoperiod expression glucose transporter genes skeletal muscle adipose tissue mice expression lower muscle mice exposed short duration day long duration day accompanying changes protein levels although expression mouse muscle higher protein levels remained unchanged confirm functional significance photoperiod induced changes expression checked variations insulin sensitivity blood glucose levels insulin injection remained high suggesting mice exposed showed lower sensitivity insulin exposed also attempted clarify relationship expression physical activity mice following changes photoperiod locomotor activity detected via infrared beam sensor lower however facilitated voluntary activity using running wheels rotation wheels similar groups mice although physical activity levels enhanced due running wheels expression muscle remained unchanged thus variations photoperiod altered expression mouse skeletal muscle subsequent changes protein levels insulin sensitivity effects independent physical activity elsevier inc rights reserved
paper presents mechanical chemical environmental degradation induced recycled construction wastes short term tensile behaviour nonwoven polypropylene geotextile reinforced pet order study chemical environmental degradation damage trial plant constructed using recycled filling material damage caused mechanical actions installation also simulated installation damage laboratory tests wide width tensile tests performed geotextile samples trial months laboratory damaged samples intact received samples short term tensile behaviour compared scanning electron microscope sem images intact specimens also presented
aiming solving problems dynamic occlusion complete field dental restoration paper presents computerized system viewpoint integration related disciplines firstly displacement matrix mandibular movement established means method direction cosine matrix spatial mechanism secondly programming matlab language technical computing visualization toolkit adopting techniques laser scanning computer graphics computer database model reconstructed coordinate data mark points measured basis model computerized simulation system contacts complete developed aid system dynamic procedure complete mounted clearly observed required angle location views addition ions contacts obtained therefore study helpful research dynamic occlusion complete improve dental procedures
mediated mrna decay surveillance mechanism ensuring fast decay mrnas harboring premature termination codon quality control mechanism distinguishes normal termination order degrade carrying mrnas connected various cell processes regulate activate specific cell conditions response mutations mis regulations stresses particular cell programs cell processes connections focus review aims illustrate complexity mechanism regulation highlight cellular consequences inhibition
hundreds intracellular peptides neither antigens present mammalian cells tissues peptides correspond fragments cytosolic nuclear mitochondrial proteins proteasome inhibition affects levels intracellular peptides human cell lines effect expression intracellular peptide profile evaluated functional significance investigated expression hela cells induced interferon gamma treatment relative concentrations intracellular peptides compared control cells using isotope labeling electron spray mass spectrometry one peptides identified corresponds amino acids human atpase regulatory subunit peptide increased extracts hela cells treated interferon gamma compared control cells vitro increased caspase like proteasome activities vivo covalently linked cell penetrating peptide potentiated ability interferon gamma stimulate expression beta subunit increase proliferation cells cell penetrating peptide construct also improved positively modulated secondary igg anti bovine serum albumin immune responsiveness elicited high antibody mice together results suggest functional intracellular peptide interferon gamma activity biological significance functional identification advances understanding regarding bioactive peptides generated limited within cells elsevier rights reserved
input output stability theory indispensable tool control engineering however classic results sector theorem applied important cases technical note extends original sector theorem apply open loop unstable systems negative upper bounds incorporates careful treatment systems alterations accounting initial conditions simulations highlight contributions facilitate robust control challenging circumstances
novel dynamic ligament smart material exhibits strongly rate dependent response extension developed characterized devices based polymers shear thickening fluids exhibit low resistance extension rates higher resist higher force link shear thickening fluids dynamic tensile performance presented explain rate dependent response future recommendations improving device performance presented along host different potential application areas including safety equipment adaptive sporting goods military equipment
patient reported outcome measures standardized validated questionnaires intended completion patients order measure perceptions health condition treatment without interpretation patients response clinician clinic score crohns disease activity index frequently used end points conventional clinical trials composite instruments fully objective capture impact disease patients perspective difficult apply routine clinical practice complex time consuming european medicines agency food drug administration evaluating composite indices clinical trials product development guidelines ultimate goal support labelling claims improve safety effectiveness medical products objective measure inflammation happens clinical practice developed validated according rigorous criteria set become primary end point clinical trials therapy together objective measure inflammation affect future trials design results find place routine care easy use acceptable patients healthcare teams able demonstrate added value normal practice supporting decision making level individual patients ideally used clinical trials practice avoid current interpreting results clinical trials translating routine clinical practice
ability accurately predict traffic loading essential cost effective bridge maintenance repair programs traffic load model currently used united states design long span bridges developed three decades ago vehicle characteristics traffic patterns changed traffic loading recent calibrated bridges long work motion traffic records different sites across used establish traffic loading traffic used generate congestion based real traffic data influence lines two typical long span bridges one cable stayed bridge one suspension bridge determined using finite element models used model estimate bridge load effects caused traffic results extrapolated find characteristic lifetime maximum values used evaluate load model assess suitability long span bridges similar way current american load model long span bridges commonly known model evaluated see accurately reflects traffic loading currently found american recent research suggested use load model estimate effects traffic loading long span bridges model also evaluated work
background year marked end united nations development goals aimed reversing worldwide tuberculosis emergence drug resistance major challenge worldwide control aim study give overview publications multi extensively totally drug resistant methods scopus database used retrieve articles multidrug resistant extensively drug resistant totally drug resistant tuberculosis study period number publications top productive countries institutions citation analysis international collaboration active authors active journals retrieved analyzed results total journal articles retrieved mean citations per article index retrieved data number publications showed three fold increase study period compared less two fold increase tuberculosis research study period stratified number publications united states america ranked first switzerland ranked first productivity per million people south africa ranked first productivity stratified per one gross domestic product three high burden countries india china south africa present top productive countries high percentage international collaboration seen among except one journal active journals publishing articles infection related fields general medicine top cited articles published journal new england journal medicine themes top cited articles diverse ranging molecular biology diagnostic tools infection hiv results new anti drugs conclusion publications increasing past decade international collaboration common many low african asian countries benefit research leading new diagnostic screening technology exchange expertise ideas technology paramount importance field
thyroiditis common autoimmune disease immunomodulatory functions various diseases double blind randomized placebo controlled clinical study investigated effects patients total patients recruited treated patients significant increased levels reduction serum tsh levels compared receiving placebo furthermore related cytokine ifn gamma changes treatment suggest immune modulating effect mediated regulating function cells overall administration effective tolerated patients results demonstrate immunological effect patients studies warranted determine longer term effects possible effects thyroid cancer patients elsevier gmbh rights reserved
novice programmers exhibit repertoire affective states time learning computer programming modeling frustration important need pedagogical intervention student otherwise lose confidence interest learning paper contextual features students within java system used detect frustration student within programming exercise session compared psychological sensors used studies use contextual logs less equipment used ubiquitous learning environment technique logistic regression regularization utilized modeling prevent fitting results showed model uses contextual features achieved prediction accuracy level recall measure thus conclude possible detect frustration student contextual logs within system adequate level accuracy
automatic voltage regulator equipment maintaining terminal voltage generators specific level time load conditions many controllers system designed based linearized normal model system robust enough uncertainties parameter variation load change system paper gray pid controller designed system controller consists two parts conventional pid controller together gray compensation controller controller gray model used estimate uncertainties online gray compensation controller constructed according estimation results eliminate effect uncertainties improve performance controllers parameters optimized new evolutionary algorithm competitive algorithm proposed controller effectively deal uncertainties system simulation results illustrate effectiveness proposed control scheme
conducted person survey new york city assess availability accessibility price counter rapid hiv self test kit stratified high moderate low morbidity neighborhoods hiv diagnosis rate neighborhood pharmacy located random sample taken high morbidity neighborhoods low morbidity neighborhoods excluded closed survey non retail min walk project staff visited determine kit availability pharmacy day survey accessibility locked behind counter price marked shelf product kits available accessible difference neighborhood kits often kept behind pharmacy counter common kits kept solely behind pharmacy counter median price without variability across neighborhoods rapid hiv self test limited availability access retail high median price measured suggests cost remained barrier
dysregulated rest activity rhythm patterns associated several health conditions older adults study showed later associated modestly greater risk falls fractures elderly men associations dysregulated patterns osteoporosis risk warrant investigation purpose study investigate relationship rest activity rhythm patterns risk falls fractures older men hypothesized dysregulated associated incident falls fractures used wrist actigraphy measure periods men years enrolled multicenter outcomes sleep disorders men sleep study men contacted every months report occurrence falls fractures parameters included amplitude difference peak activity counts minute activity counts minute time day peak activity pseudo statistic rhythm robustness evaluated continuous variables associations reported per increase decrease models adjusted confounders logistic regression used estimate likelihood odds ratio recurrent falls year visit proportional hazards models used estimate risk hazard ratio fractures one year visit men recurrent falls later associated modestly greater likelihood falls years years complete follow men major osteoporotic fracture clinical spine fracture hip fracture consistent significant associations observed patterns fractures later associated modestly greater risk falls association translate higher fracture risk cohort elderly men
electrical stimulation releases several endogenous play important roles management pain inflammation low high frequencies shown release different suggesting various therapeutic effects pain edema major problems ankle however reports effects ankle aimed investigate reduce pain edema resulting ankle whether difference therapeutic effects low high frequency induce ankle sprague dawley rats ankle right direction simultaneous inversion flexion stepping force edema ankle measured electronic balance respectively groups stepping force increased significantly similar degrees produced significant rapid decrease ankle edema study demonstrates shows comparable analgesic effects facilitate reduction edema caused ankle
scope analysis tune proportional integral derivative pid parameters autonomously controlling moisture content paper industry using genetic algorithm particle swarm optimization pso algorithm pso based pid tuning results compared conventional based pid tuning examine performance time domain specifications hence suited marine application real time prototype model paper machine designed controlled using microcontroller embedded programming language model used measure moisture content level paper
enabling technology cell biology chemical analysis combine attributes microfluidic device line solid phase extraction mass spectrometry analysis secreted metabolites living cells culture chip device constructed contains chamber cells multilayer design allowed series valves control chip injection loop downstream cell chamber operation similar six port valve valve sample packed bed connected line treat samples prior analysis valve allows samples collected injected onto bed preventing exposure cells added back pressure bed organic solvents needed collected chemicals cultured murine adipocytes loaded cell chamber non fatty acids secreted cells monitored min intervals limit detection acid standard due detection capabilities variety detected upon stimulation secretion select elevated average fold compared basal levels despite min delay sample injections device step towards miniaturized system allows automated monitoring identification variety molecules extracellular environment
care patients complicated best assessment provided data available practitioner however data time consuming gather especially setting practice environment duty hour restrictions electronic medical record specifically designed needs reasons complete clinical picture especially historical component sometimes assembled address shortcomings authors created patient level electronic csf shunt history tool leverages power concordant united states centers medicare medicaid services meaningful use principles immediately available within users patient care contexts outpatient inpatient operative emergency remote access centrally located designed capture vast range circumstances inherent population essential shunt data rapidly acquired decrease likelihood error diagnosis treatment tool also potential aid practicing clinical quality improvement research authors describe tool manner allow interested share publication health information technology professionals facilitate development similar tool within institutions platform
microbiological quality drinking water concern consumers water regulators public health authorities alike monitoring microbiological quality drinking water largely relies examination indicator bacteria like escherichia coli coli widely used indicator fecal pollution monitoring microbial quality drinking water abundant therefore found sewage natural waters contaminated fecal matter human origin wild animals derived agricultural activity paper describes development novel rapid detection coli drinking water based specific cellular biomarker measurement system based tube captures fluorescence signal produced cellular biomarker excited ultraviolet led cellular biomarker also developed consists chimeric protein green fluorescent protein gfp terminal domain specific amino acid sequence terminal domain targets specifically structure detected instrument simple use lightweight powered either power battery making excellent choice rapid detection coli drinking water field studies laboratory measurements
study proposes new pid controller auto using frequency sampling filters estimation plant frequency response information relay feedback control differs existing auto estimation plant frequency response information utilisation frequency domain based pid controller design desired closed loop time constant selected user scaling factor estimated open loop time constant simulation examples used demonstrate efficacy auto characteristics disturbance rejection reference following indicating auto produces satisfactory closed loop control performance commonly encountered systems process control addition monte carlo simulation studies used demonstrate model based algorithm requires shorter experimental time achieve higher accuracy estimation also provides much improvement traditional fourier analysis based approaches disturbances encountered relay experiments
emerging infectious diseases always one major threats public health although implementation mandatory testing classical transfusion transmitted infectious human immunodeficiency virus hepatitis virus hepatitis virus reduced transfusion risk pathogens potential threat various agents constantly evolving variants blood safety china fully understood review presents representative agents epidemic nationally china epidemiologic status distribution agents among donors healthy populations summarized potential risks agents blood safety discussed review also explores strategies strengthen systems studies evaluate impact agents blood safety elsevier inc rights reserved
non emerging opportunistic pathogens humans animals veterinary point view species induce cross reactive immune responses diagnosis bovine tuberculosis livestock little information available species circulating species south africa study determined diversity isolated species south africa thirty known species unidentified closely related mycobacterium mycobacterium identified isolates cultured years using combination molecular assays viz pcr sequencing different house keeping genes single nucleotide polymorphism snp analysis identified study include following species isolated tissue tuberculosis like lesions absence mycobacterium tuberculosis complex implying potential role pathogens animals mycobacterium mycobacterium mycobacterium species closely related mycobacterium mycobacterium mycobacterium mycobacterium mycobacterium mycobacterium mycobacterium mycobacterium mycobacterium potential novel mycobacterium species closely related mycobacterium found first time study potential pathogens animals mycobacterium isolated sample originating skin test positive reactor demonstrating potential elicit inappropriate immune responses animals interfere diagnosis tuberculosis immunology mycobacterium frequently detected identified isolates species also isolated animals showing pathological changes knowledge gained study contribute understanding species circulating wild animals south africa pathogenic potential certain species whose role disease need examined certain extent potential diagnosis
broad spectrum autoimmunity now described patients primary management autoimmune disease background pid particularly challenging given seemingly discordant goals immune support immune suppression growing ability define molecular underpinnings immune dysregulation facilitated novel targeted therapeutics review focuses mechanism based treatment strategies common autoimmune inflammatory complications pid including autoimmune disease gastrointestinal disease aim provide guidance regarding rational use agents complex pid patient population authors published elsevier inc behalf american academy allergy asthma immunology open access article license
introduction common serious side effect antipsychotic medications currently used treatment patients schizophrenia approaches offer possibility identifying patient specific biomarkers predicting risk side effect investigated possible relationship variants snps genes cytochrome dopamine receptor serotonin receptor antipsychotic drug induced patients schizophrenia methods overall russian patients schizophrenia aged included serum prolactin concentration measured elisa dna analysis genotyping genes done real time pcr system using taqman snp genotyping assays applied usa results study showed association gene polymorphism patients schizophrenia background therapy associations identified gene polymorphism risk antipsychotic induced patients schizophrenia conclusion study confirms contribution genetic factors antipsychotic induced patients schizophrenia studies required unravel genetic predictors antipsychotic induced side effects develop personalized treatment strategies patients schizophrenia
introduction blood brain barrier dynamic biological interface actively controls passage substances blood central nervous system cns biological functional plays crucial role maintaining brain homeostasis deterioration functions prodromal many cns disorders conversely hinders delivery drugs targeting brain treat variety neurological diseases area covered article reviews recent technological improvements innovation field modeling including static dynamic cell based platforms microfluidic systems use stem cells printing technologies additionally authors laid integration stem cell biology holistic approach development novel vitro platforms expert opinion development effective cns drugs hindered lack reliable strategies mimic cerebrovascular impairments vitro technological advancements modeling development highly integrative quasi physiological vitro platforms support process drug discovery advanced vitro tools likely current understanding cerebrovascular modulatory mechanisms
purposes study determine extent acute session high intensity intermittent exercise followed concurrent strength session increase systemic inflammatory cytokines chemokines whether eight weeks high intensity interval training plus concurrent strength training alters acute inflammatory response immune status ten active males aged years performed two experimental exercise sessions eight weeks plus concurrent strength training experimental exercise session composed run maximal aerobic speed mas min passive recovery back exercises performed four sets serum samples collected fasting pre post pre post min session comparison concurrent exercise sessions performed using repeated measure anova bonferroni post hoc necessary interleukin presented moment effect post significantly higher pre post min tendency found pre post difference mcp present effects condition moment interaction presented moment interaction effects pre post significantly higher pre interaction eight weeks concurrent training probably occurred post addition maintenance immune function observed therefore concurrent strength exercise lead increase cytokines response eight weeks training program promoted response acute session concurrent exercise elsevier ltd rights reserved
proximal urinary bladder play important roles previously shown released guinea pig bladder inhibit detrusor contractile responses presently investigate actions guinea pig flow region distribution receptors effects intact proximal studied organ bath experiments expression receptor proteins analysed western blot immunohistochemistry used identify distribution receptors dose dependent manner inhibited contractions induced electrical field stimulation inhibited spontaneous contractions proximal equally slightly less potent compared expression receptors found male guinea pig bladder neck proximal proximal receptors found membrane smooth muscle cells weak observed receptors distributed widespread weakly smooth muscles inhibitory effects motor activity guinea pig proximal consistent finding receptors located smooth muscle cells proximal therefore modulator bladder flow region possibly function regulation role overactive bladder syndrome
introduction risky sexual behaviours recognized threat sexual reproductive health aim article shows results project youth health information relation determining large sample university students italy cope health especially domains sexual transmitted infections stis fertility vaccination preventable disease methods questions survey sexual behaviour reproductive health analysed besides results stratified sex age class socio economic status results students first sexual intercourse age female students used emergency contraception sexual active students reported using contraceptives used methods ineffective stis general low coverage vaccination revealed men woman never examinations discussion overall young adults italy still enough sensitized fertility care high schools universities increase awareness towards preservation male female fertility care
parents children diagnosed disabilities often experience elevated levels stress compared parenting children without disabilities increase stress negative impact parent resulting stress induced dysregulation immune system article issue found increased levels social support served protection dysregulation current study examined nature beneficial components formal support services targeted reducing stress levels parental caregivers children developmental disabilities meta analytic review attempt examine efficacy interventions potential moderators effects reviewing comparison group studies conducted north america parent stress interventions stress outcome measures six studies identified met reviews criteria reporting overall effect sum stress management interventions found effectively reduce reported stress parents caring children developmental disabilities significant issue identified limited number comparison group studies examined stress management interventions population implications findings need exploration discussed
recently interest towards electrostatic actuators machinery increased use mems renewable energy applications effective electromechanical power conversion using requires dielectric liquids whose permittivity breakdown field strength facilitate adequate electric shear stress pressure beyond capabilities media air vacuum paper discusses design points practical electrostatic force production evaluates available shelf dielectric liquids terms electric pressure capability key dielectric properties including pressure breakdown field strength relative permittivity conductivity measured custom test stand measures attractive force two electrodes mounted load cells inside tank filled liquid test measurements demonstrate liquids capable reaching several psi electric pressure correlating analytical finite element models ultimately forming basis electrostatic actuator machine design best liquid candidate proof concept macro scale electrostatic machine demonstrating torque torque measurements verify capability correlation electric pressure shear stress rotating machine
rationale considerable variability severity distribution destruction throughout lungs upper lobe predominant emerged important predictor response lung volume reduction surgery yet alpha deficiency genetic determinants distribution remain largely unknown objectives identify genetic influences distribution non alpha deficient smokers methods total subjects complete genotype computed tomography data genetic epidemiology chronic obstructive pulmonary disease copd non hispanic white african american evaluation copd longitudinally identify predictive surrogate endpoints genetics chronic obstructive lung disease studies analyzed two computed tomography scan distribution measures difference upper third lower third ratio upper third lower third tested genetic associations study subjects separate analyses study population followed fixed effect single nucleotide polymorphism gene pathway based approaches used silico functional evaluation also performed measurements main results identified five loci associated distribution genome wide significance loci included two previously reported associations copd susceptibility near near three new associations near gene set analysis silico functional evaluation revealed pathways cell types potentially contribute pathogenesis distribution conclusions genome wide association study identified new genomic loci associated differential destruction throughout lungs findings point new biologic pathways expand diagnostic therapeutic approaches chronic obstructive pulmonary disease
like factors family zinc finger transcription factors found many species recent studies shown play fundamental role regulating diverse biological processes cell proliferation differentiation development regeneration note several also crucial maintaining hence linked reprogramming regenerative medicine approaches review crucial functions mammalian stem cell biology regeneration revealed studies animal models also highlight implicated human diseases outline potential avenues future research
microorganisms autonomous motility along concentration gradients chemical species important yet often neglected factor controlling transport bacteria saturated porous media example bacteria enhance directing motion residual contaminants trapped low hydraulic conductive zones contaminated aim present work develop accurate numerical scheme model saturated porous media flow systems propose model using new class lagrangian particle methods recently developed applications fluid mechanics method based smooth particle hydrodynamics formulation int math combined new weighted essentially non oscillatory reconstruction technique moving point clouds multiple space dimensions purpose new numerical scheme fully exploit advantages among traditional mesh based mesh free schemes overcome drawbacks related use standard modeling porous media first test new scheme analytical reference solutions assumption complete mixing scale perform two dimensional conservative solute transport simulations steady state flow conditions show capability proposed new scheme model
according cognitive theories personality disorders antisocial personality disorder aspd based upon distinct set cognitive behavioral representations aim study examine comparing early maladaptive schemas core beliefs young antisocial men set socio matched healthy individuals used schema questionnaire social comparison scale identify evaluate subjects core beliefs thirty eight antisocial individuals healthy control subjects participated study results indicated antisocial patients see rejected results indicated antisocial patients significantly elevated clinically relevant scores comparison controls following areas emotional deprivation abuse vulnerability harm illness social isolation general results present study indicate aspd individuals demonstrate common profile core beliefs unique individuals diagnosed aspd implications findings discussed cognitive behavioral theory treatment aspd
research suggests body mass index bmi weight suppression highest past weight current weight important determining adult anorexia nervosa severity examined associations dsm bmi severity category highest bmi among patients adult female spectrum patients two residential treatment facilities admission height weight measured participants completed questionnaires assessing menstrual status weight history adjusted bmi associated menstrual function admission first onset occurred normal bmi participants highest bmi positively correlated bmi onset higher bmi onset associated higher bmi findings add literature indicating relative absolute weight status dual indicators illness severity suggest large proportion adults present treatment initially shown symptoms normal bmi results underscore need focus weight loss early detection efforts inform target weight setting treatment
water widely prevalent developing countries affecting lives people including miss classes water daily use typical case primary school east africa rainwater harvesting rwh system constructed easy adaptability technology purpose study sustainability evaluation evaluation considered construction details level water supply service potential sustainability replication coarse screen first tank sedimentation tank included maintaining water quality particle load reduction water level gauge incorporated enables easy monitoring water usage provided training operational manual practical guide system management users local labor material techniques used recommended capacity building sense ownership cost reduction companies involvement encouraged providing financial support schools corporate social responsibility rwh thus suggested sustainable alternative drinking water supply
elastic optical networks play important role next generation core networks especially supporting cloud computing however network traffic growing exponentially almost reached physical capacity limit single mode fibers space division potentially employed increase fiber capacity multi core fibers make use aggregate multiple cores together one fiber greatly increase capacity new crosstalk constraints flexible compared communications widely used cloud computing distributed computing distributed storage system content delivery networks letter planning problem evaluation results show tools solve small size problems scale therefore propose heuristic algorithm efficiently solve problem best knowledge first work considers routing
purpose review human genetic studies successfully used identify genes pathways relevant human biology using genetic instruments composed loci associated human lipid traits recent studies begun clarify causal role major lipid fractions risk cardiometabolic disease recent findings causal relationship ldl cholesterol coronary disease established remaining two major fractions recent studies found hdl cholesterol likely causal particle instead shifted causal focus triglyceride rich subsequent results refining view suggest triglycerides causal instead surrogate causal cholesterol content within fraction studies used similar approach address association lipid fractions risk type diabetes beyond genetic variation target medications reduced ldl cholesterol associated multiple genes encoding current prospective drug targets associated increased diabetic risk addition genetically lower hdl cholesterol genetically lower triglycerides appear increase risk type diabetes summary results future human genetic studies positioned provide insights causal relationship lipids human disease highlight mechanisms important implications understanding human biology future lipid altering therapeutic development
substance use complex clinical problem characterized emotion dysregulation daily challenges interfere laboratory research thus studies examine autonomic self report measures emotion dysregulation chemically dependent samples extend work naturalistic settings study used within subject design examine changes respiratory sinus arrhythmia activity self reported affect across three tasks designed elicit distinct emotional response patterns also examined emotion dysregulation moderator responses participants include women multiple comorbid mental health conditions enrolled substance use treatment many also reported high emotion dysregulation participants assessed treatment setting completed three tasks watching sad movie rumination stressful event awareness multilevel models used examine changes resting tasks film results indicate significant decrease increase rumination task participants showed decrease response body awareness task increase decrease emotion dysregulation associated differences baseline slope response patterns across tasks self reported affect largely consistent autonomic patterns findings add literature emotion dysregulation substance use translation measurements clinical settings complex samples
software project scheduling dynamic uncertain environments significant importance real world software development yet studies schedule software projects considering static deterministic scenarios cause performance deterioration even facing disruptions order capture dynamic features software project scheduling previous work paper project scheduling problem considering uncertainties dynamic events often occur software project development constructs mathematical model resulting multi objective dynamic project scheduling problem four objectives project cost duration robustness stability considered simultaneously variety practical constraints order solve appropriately multi objective evolutionary algorithm based proactive method proposed generates robust schedule previous schedule response critical dynamic events project execution extensive experimental results problem instances including three instances derived real world software projects show novel method effective introducing robustness stability objectives incorporating dynamic optimization strategies specifically designed proactive method achieves good overall performance dynamic environment
paper reviews studies conducted performance american football preventing review also guide understand problems still exist research directions take throughout history sports injuries limiting career life athletes leading concern sport authorities injuries extensive sports athletes severe contact mild traumatic brain injury widely occurs american football frequent players heads includes several types neurological dysfunctions headache dizziness confusion vision delayed reaction time etc lots studies focused understanding improving protective performance dose injury players reduced researches area classified two major methods experimental studies finite element modeling fem simulations experiments researchers tried head impacts reconstruct severe collisions using game videos laboratory conditions used hybrid iii order study effects different impact parameters direction velocity region head hit etc studies done analyzing dynamic responses head acceleration rotational acceleration different head injury criteria like head injury criteria severity index mentioned impact parameters also examined using fem simulations researchers applied results experimental tests including linear rotational acceleration order study brain deformation responses different types impacts regards brain deformation responses like maximum principal strain considered analyzed using head injury thresholds authors published elsevier open access article license
understanding basic concepts electronics computer programming allows researchers get equipment found laboratories although number platforms specifically designed general public supported vast array line subject normally included university chemistry curricula aiming provide basic concepts hardware software article focused design use simple module control series based valves module based low cost open source software arduino fabricated using thin sheets using laser providing simple efficient way fabricate devices without traditional process facilities synchronization valve control enabled development two simple devices perform injection stroke mixing different solutions furthermore practical demonstration utility system chemical sample handling analysis achieved performing chip acid base titration followed conductivity detection open source low cost detection system overall system provided reproducible platform perform fluid delivery microfluidic scale
background mandibular joint replacement used clinically years objective study evaluate outcomes achieved patients two different categories material methods patients replacement implanted study period included year prospective study procedures performed using replacement system involved replacing skull base component mandibular results fifty seven patients females males involving severe disease requiring reconstruction unilateral bilateral operated consecutively stock custom made implanted mean age surgery years stock group years custom made group stock group three years results showed reduction pain intensity improvement opening custom made group three years results showed reduction pain intensity improvement opening statistically significant differences two groups detected conclusions results three year prospective study support surgical placement stock prosthetic custom made systems show approach efficacious safe reduces pain improves maximum mouth opening movement complications represents viable technique stable long term solution mandibular reconstruction patients irreversible end stage disease comparing stock custom made groups statistically significant differences detected respect pain intensity reduction maximum mouth opening improvement
purpose review purpose review summarize recent advances understanding complex immunology intestinal transplantation allograft rejection recent findings recent findings highlight importance intestinal microbiome intestinal homeostasis role newly discovered innate lymphoid cells intestinal transplantation addition role host antimicrobial responses pathogenesis inflammatory bowel diseases intestinal allograft rejection elucidated summary research complex immune system intestine continued reveal connections study performed making treatment intestinal transplant patients multifaceted interaction communication relationships areas microbiome innate lymphoid cells cells reveal possible targets therapy areas requiring ongoing research
background optimisation control programs warrants good knowledge main vector animal human sub saharan africa fly important aspect fly population infection prevalence determines intensity transmission parasite vector therefore conducted systematic review published studies documenting infection prevalence field surveys laboratory experiments controlled conditions publications screened web science pubmed google scholar databases using four stage identification screening eligibility inclusion process prisma statement initial screened total studies reduced studies microscopic examination dissection method remains used method detect thus constituted main focus analysis meta regression performed identify factors responsible high prevalence vectors random effects meta analysis used report sensitivity molecular serological tests using dissection method gold standard results overall pooled prevalence confidence interval field survey laboratory experiment data respectively country year publication found significantly factors associated prevalence infection alternative diagnostic tools applied dissection positive samples characterised low sensitivity information specificity available conclusion temporal spatial variation infection prevalence field collected exists investigation real risk factors needed variation explained improving sensitivity determining specificity alternative diagnostic tools priority allow estimate prevalence infection high throughput
differences esterase expression among human dog rabbit rat mouse plasma identified using native polyacrylamide gel electrophoresis ubiquitous species highly expressed primates dogs whereas abundant rabbits mice rats several unknown observed mouse plasma differences plasma expression levels result species differences respect hydrolase activity differences characterized using several different substrates contrast high hydrolase activity found substrate several hydrolase enzymes compound resistant plasma derivatives rapidly mouse rat plasma highly active enzyme rabbit plasma derivatives interestingly derivatives highly plasma whereas human dog plasma showed negligible activity conclusion esterase expression pattern dog plasma found closest human plasma differences considered selecting model animals preclinical studies wiley periodicals inc american pharmacists association sci
vehicle induced vibration important consider assessing structural safety bridges issue widely investigated recent years open literature current research studies mainly emphasize effects bridge span vehicle however driving effects driving speed vehicle model parameters driving conditions rarely investigated study researches driving effects vehicle induced vibration long span suspension bridges conducted first typical three dimensional vehicle model multi proposed three different road roughness models rated excellent good normal generated power spectral density random traffic flow vehicle types simulated using proposed random traffic flows model generation program next effective finite element model beams girder established investigate driving effects vehicle induced vibration calculations effects vehicle body parameters road roughness driving direction speed performed possible reasons driving effects vehicle induced vibration long span suspension bridges also discussed addition conclusions recommendations future bridge analysis design provided based results study copyright john wiley sons ltd
measurement large deformations represents challenging issue many engineering applications name aerospace structures due intrinsic large deformations require dedicated sensing systems able capture current geometry shape reconstruction detect stress level structural health monitoring conventional sensors one hand due material structural limitations assure adequate measurement interfere instrumentation optical fiber technologies present advantages terms channels number needs furthermore specific information carrier light prevents interference systems finally limitations measurement due glass intrinsic fragility overcome integrating sensors dedicated strain modulation supporting structure paper hand just focuses fiber based sensors conceived modulate large strains transducer design phase illustrated moving specifications design parameters identified optimal configuration assessed preliminary manufactured tested allowing comparison numerical outcomes proposed concepts exhibited wide measurement range high level versatility due possibility tuning sensors different measurement conditions work ends critical discussion enhancements achievable activities yet necessary increase readiness level
current studies presented multiple understandings meanings concept agile project management however formal definition agile project management relates underlying theoretical foundation project management agile project management literature study presents various concepts project project management order final research based definition agile project management consequently formal definition agile project management constructed result paper concludes set recommendations research agile project management paper portion ongoing computer information systems research effort agile frameworks
objective investigate clinical characteristics developmental profile child abuse victims assessed child assessment service hong kong method retrospective chart review conducted children multidisciplinary case conference concluded child abuse victims assessed studied age sex condition matched comparison group also selected comparison results fifty five children boys girls studied developmental delay intellectual disability attention deficit hyperactivity disorder problem two major developmental disabilities identified types abuse included physical abuse neglect sexual abuse multiple abuse parent parents psychiatric problems substance abuse single parenting low income families children developmental problems associated higher risk child abuse conclusions psychosocial risk factors child abuse identified children developmental problems assessed support children disadvantaged families important child protection
morbid obesity remains one significant medical rapidly worsening expected affect population year common current bariatric procedures exist include limited adjustable gastric band gastric bypass although beneficial obese patients also alter patients anatomy involve require maintenance goal trial show new minimally invasive vertical gastric technique produces significant weight loss requires resection change anatomy reversible november february prospective collected data patients included gastric trial consists covered titanium backbone inferior opening medial lumen excluded lateral gastric inferior opening allows gastric empty body stomach distal weight loss comorbidities evaluated among patients month period excess weight loss seen minimal adverse events average length surgery min average length stay days fifteen originally implanted clips removed based original protocol two removed displacement device vertical gastric trial shown excellent weight loss achieved without complications seen historical bariatric procedures placed without requiring resection change anatomy maintenance also easily reversible
year old female presented first case knowledge new daily persistent headache large right benign non toxic causing carotid vertebral compression complete resolution headache immediately although quite rare hypothyroidism hyperthyroidism causing migraine exacerbation pre existing migraine clinicians consider routinely obtaining serum thyroid stimulating hormone tsh free patients new onset frequent headaches exacerbation prior primary headaches
inflammation play role development epilepsy brain binds expressed activated microglia quantified binding induced status model temporal lobe epilepsy nine male rats studied induction session weighted images dti mean diffusivity fractional anisotropy maps acquired followed dynamic pet femoral arterial blood sampled rat specific metabolite corrected arterial plasma input functions multiple derived assessed four kinetic models two two using reference region standard uptake values model mean models showed large two fold significant binding increases regions expected affected comparatively little change brainstem individuals showed increases models yielded consistent increases values decreased recovered increased pet binding biomarker changes detected nine rats highlighting potential longitudinal imaging studies
water pollution permit systems challenging design implement operational systems maintained functionality remains far particularly developing countries present current progress towards developing system nutrient enrichment based water pollution mainly commercial agriculture applied production function approach first estimate monetary value impact pollution used reference point establishing reserve price pollution permits subsequent market making process explained according five steps including permit design terms conditions protocol monitoring system implementation monetary value impact pollution estimated per per year provide management budget green algae mitigation strategies study area also enabled calculation reserve price green algae pollution permits estimated per gram algae per gram preferred state elsevier ltd rights reserved
introduction olfactory migraine attack rare phenomenon present considered manifestation migraine aura material methods clinical features collected patients results patients migraine without aura one migraine aura associated mean age onset headache appearance respectively years migraine average frequency attacks month associated temporal pattern maintained characteristics different attacks onset described sudden gradual initially sudden gradual developing seconds cases lasted minutes persisted pain phase hours three patients type perceived constant nine patients conclusion features fulfilled iii beta criteria typical aura
induced skeletal muscle damage rats associated reduction resting chloride conductance chloride channel expression drugs also affect regulation increasing protein kinase activity close channel also intracellular resting calcium level increased similar alterations observed skeletal muscles aged rats suggesting higher risk verify hypothesis performed weeks treatment months old rats evaluate channel function two intracellular technique transcript protein expression different genes sensitive quantitative real time pcr western blot analysis measured using imaging histological analysis muscle sections performed results show marked reduction resting agreement reduced mrna protein expression treated aged rats respect treated adult animals observed changes enhancer factor expression involved expression changes activity also increased modulate treated aged rats parallel marked reduction expression mitochondrial enzymes demonstrates impairment muscle metabolism worsening histological features found treated aged animals findings suggest strong reduction alteration muscle metabolism coupled muscle atrophy contribute increased risk induced elderly elsevier inc rights reserved
ubiquitous ester bond water insoluble substrates insoluble substrates acting aqueous low water media thus considerable physiological significance high interest also industrial applications hydrolysis reaction follows two step mechanism interfacial activation adsorption enzyme heterogeneous interface subsequent enhancement activity among candida lipase never shown significant interfacial activation closed conformation never reported leading conclusion behavior due absence regulating access active site open closed states observed crystal structure resolution open closed states atomic resolution allows relating conformation indicating role conformation alteration findings explain lack interfacial activation offer new elements elucidate mechanism consequent implications catalytic properties classification
due exciting catalytic activity selectivity tailoring nano catalysts consisting preferred crystal facets desired structural properties remains materials engineering facile one step synthesis nanocomposite reduced graphene oxide one dimensional nitrogen doped exposed facet described performed dual role nitrogen source agent control size unidirectional growth nano composite showed efficient visible light mediated lambda water splitting cell plausible mechanism formation improved efficacy terms oriented growth proposed
present application detector compact pixel detector square pixels sensitive hard ray radiation suitable detecting rays due low noise characteristics enables measuring without special cooling project aims verify practicality detector conjunction eye optics observe sources modified interface developed used low level control additional bit microcontroller dedicated detector process data satellite present software methods post processing captured images suitable implementation constraints low powered embedded hardware several measuring modes prepared different scenarios including single picture exposure solar light triggered exposure long term monitoring work done within collaboration satellite planned launch april part project end life expectancy
ambient intelligence aml discipline makes environments visit everyday sensitive adding sensors measure surroundings actuators interact environment people problem emerges trying convert space ambient intelligence environment modify one already exists simulator help optimal set without need money installing required devices achieved desired configuration paper propose architecture integration social simulation network simulation order create whole ambient intelligence environment simulator
background differences hepatic organic anion transporters compared rats identify causative factor early stage acute hepatic failure methodology male wistar rats weeks randomly assigned one two groups sacrificed hours expression bile salt export pump multidrug resistance proteins sodium dependent polypeptide organic anion analyzed northern blotting serum liver function tests also performed results postoperative survival rates hours respectively mrna expression increased decreased values significantly greater hours contrast expression regulated half preoperative level increased mrna expression uptake transporters decreased similar extent total serum bile acid levels significantly increased procedures greater extent conclusions alteration mrna expression characteristic behavior early stage acute liver failure
silicon offers possibility reduction size weight power many optical systems open ability build optical systems complexities otherwise impossible achieve silicon emerging technology already inserted commercial communication products technology also applied analog signal processing applications laboratory collaboration groups developed toolkit silicon photonic devices focus needs analog systems toolkit includes low loss high speed modulator ring resonator based filter bank silicon components integrated together hybrid photonic electronic analog digital converter development performance devices discussed additionally linear performance devices important analog systems also investigated
alteration expression mirnas correlated different cancer types tumour stage response treatments context structurally responsive oligonucleotide based electrochemical biosensor developed simple sensitive detection mirna highly specific dna molecular probe conjugated gold nanoparticles create integrated dual function bio label signal generation presence target mirna takes place resulting activation event makes group previously protected stem loop structure accessible activated mirna complexes become available capture via interaction onto modified electrode electrochemical transduction binding event results decrease charge transfer resistance working electrode electrolyte interface biosensor responded linearly range mirna limit detection good reproducibility relative standard deviation high selectivity mirnas mirna sequences detection mirna spiked serum samples clinically relevant levels low range also demonstrated thus illustrating potential biosensor point care clinical applications proposed biosensor design based combination surface dual function bio label provides simple robust approach detection short length nucleic acid targets mirnas
therapists potential clients similarly evaluate offices practicing clinicians therapists office create environment yet little research examines perceptions leading focus research previous study color photographs offices students favored clinical settings soft personalized using photographs present studies licensed evaluate quality care comfort setting therapist qualities expected clients experience office judgments therapists thought clients make high correlations earlier judgments students groups composite evaluation improved significantly office became brief report concludes features likely create therapeutic office
human protein tyrosine phosphatase non receptor type prevents cells death targeting domain protection triggers apoptosis demonstrate domain inhibits phosphatase activity mere binding ligand sufficient release catalytic inhibition combined analytical small angle ray scattering nmr understand domain controls activity show physiologically active two domain encompassing phosphatase domains adopts predominant compact conformation solution ligand binding catalytic competence disrupting transient communication study emerging notion domains act regulators enzyme activity therefore active players dynamic regulation signaling pathways
changing land use due rapid urbanization profound impact runoff urban watersheds spatial analysis urban watersheds felt necessary management surface subsurface water regimes significant increase zones observed urban watersheds impacts runoff even flash floods observed study presents spatial temporal impacts change urban built area curve number runoff years study also analyzes effect slope values shows increases slope high resolution satellite images used map surface areas show increase spearmans pearsons coefficients generated establish relationship runoff surface areas vegetation index slope runoff coefficient assumed rainwater harvesting considered estimated runoff reduces compared year study suggests increase areas within urban watersheds utilized groundwater augmentation adopting rainwater harvesting techniques prevent flash floods
radio programs satellites mobile users operating many years united states canada south korea service generally called satellite radio provided band radio frequencies satellite radio users require near perfect service availability since users mobile reception antennas receivers little gain high effective power satellite provide required availability particularly conditions despite using satellite transmitting antenna achievement high requires satellite transmitter radio frequency power output typically achieved traveling wave tube amplifiers configuration usage technical aspects satellite described satellite critical satellite radio service performance operating lifetime typically years importance detailed lifetime laboratory testing done reported herein elsevier ltd rights reserved
previous studies borderline personality disorder bpd development suggest transmission parent child relationship quality also influenced parents mental health status aim study twofold first aimed investigate effect parental bonding experiences development bpd offspring second examined association parents mental health status bpd offspring ninety one female adolescent psychiatric inpatients along mothers fathers enrolled study adolescent bpd assessed structured clinical interview dsm parental bonding parental bonding instrument parents psychiatric symptoms patient health questionnaire found low parental care produced effect mother bpd offspring significant associations found paternal psychiatric symptoms adolescent bpd high paternal stress levels mediated association maternal affect reported fathers bpd evidence effect parental bonding specifically female adolescents bpd compared clinical control subjects findings highlight importance including parents future research early clinical treatment adolescents bpd
according gender role theory individuals confirm expectations associated gender roles judged expectations parental roles strongly tied gender different expectations behaviors mothers fathers study examined mothers fathers behaviors support positive relationship parent perceived terms acceptability two hundred eight parents completed online survey assessing perceptions acceptability negative parental positive behaviors results provided support hypothesis although parental behaviors rated acceptable mothers fathers expectancy violation theory explain parental behaviors viewed negatively mothers exhibit fathers
social scientists long debated best measure pregnancy intentions standard measure relies mothers retrospective reports intentions time conception women already given birth time report resulting childrens health including vital status influence mothers responses hypothesize women less likely report children unintended pregnancies explain cross sectional studies shown children unintended pregnancies higher survival despite fact longitudinal studies shown opposite true using demographic health survey data sub saharan african countries confirm mothers less likely report children resulted unintended pregnancies compared children however opposite true unhealthy children mothers commonly report unhealthy children unintended pregnancies compared healthier children results suggest mothers recall intentions traumatic experience child death alter reports face face interview study challenges reliability retrospective reports pregnancy intentions high mortality settings thus also current knowledge levels consequences unintended pregnancies contexts
paper presents new approach develop web server remote systems engineering automatic control laboratories based easy simulations one hand development runtime platform distribute non blocking data intensive event driven real time applications across different devices used server hosts laboratory web pages support real time communication controller back end application control loop plant front end graphical user interface students observe behavior controllers systems study web one powerful intuitive graphical tool develop graphical interactive interfaces simulations used generate controller front end new strategy different operating system linux mac windows different controller back ends application developed logic controller labview virtual instrument lightweight versatile solution set friendly remote control laboratory whose experiments accessed students different types devices pcs tablets smartphones ifac international federation control hosting elsevier ltd rights reserved
modern systems use infrared imaging tracking target detection algorithms development validation processes systems need high fidelity simulations capable stimulating sensors real time infrared image sequences synthetic environment extensible image generation modular software library developed germany generation physics based infrared images real time able render images full bit floating point precision using state art computer graphics advanced programs important functionality infrared image generation simulation thermal cause matching errors tracking algorithms however real time simulations hardware loop simulations infrared thermal often neglected require thermal balance calculation four dimensions geometry one dimensional time several hours past paper show novel real time thermal simulation thermal simulation capable simulating thermal effects real time environments thermal resulting occlusion direct indirect irradiance conclude paper practical use simulation
racism framed threat ones security article draws qualitative life history interviews conducted people part existing longitudinal health study based city narratives revealed perceptions racism significant consideration people asked reflect identity wellbeing time though less frequently overt racism often seen within ones social circle revealing complicated process engaging ignoring avoiding defining racism findings highlight agency people adapting behaviour avoid minimise insecurity
development technologies means human machine interface turning one attractive areas todays research innovation power consumption signal processing wireless communication focus development systems however devices reached mass market yet system incorporates texas embedded processor wireless communication solutions highly customized analog front ends proof concept technology integrates architecture instrumentation amplifiers analog front end single supply amp analog signal processing effective manner development cost effective versatile system impact clinical control applications developing countries thus domain
background sexual behavior young people influenced external factors increase vulnerability objective describe sexual behavior indicators sexual reproductive health among young people years identify factors associated sexual risk behaviors methods cross sectional study carried online survey panel population factors associated using condom last sexual intercourse evaluated using multivariate logistic regression models results boys girls reported complete sexual intercourse proportion boys girls reported partners respectively boys girls reported contacted partners internet using condom first sexual intercourse showed significant association reporting using condom last sexual intercourse boys girls contacted partners internet associated risky sexual behavior boys used emergency contraception times associated girls conclusions differences sexual behavior young people sex condom use first sexual relationship good predictor condom use last sexual intercourse boys show higher number partners girls higher use internet contact sexual partners
alzheimers disease increasing prevalence significant impact caregivers healthcare system one many physiologic process affected circadian system disruption reflected abnormalities sleep wake cycle interaction bidirectional circadian sleep disruption influencing disease progression understanding bidirectional relationship circadian disruption allow earlier recognition potential develop dementia improved targeted approaches therapy therapies including melatonin bright light therapy advantageous improving sleep circadian rhythms preventing progression disease however unfortunately modalities curative additional research needed improve treatment options individuals
deep brain stimulation nucleus applied attenuate drug relapses animal studies clinical treatments however mechanisms produces therapeutic effects remain largely unknown study first combine enhanced magnetic resonance imaging mri explore effects relapse pathway rats images suggested produced activation verify activating effects expression levels protein encoded immediate early gene fos following measured using methods intra increased fos expression site stimulation prefrontal cortex increased fos expressing activity consistent previous study demonstrating attenuated cocaine via local activation activation medial prefrontal cortex examination block fibers test inactivation target fibers attenuated effects seeking moreover gaba receptor antagonists administered weakened effect gaba receptor agonists attenuated seeking elsevier inc rights reserved
propose deterministic fluid model operation two tandem overload conditions using model categorize overload scenarios several classes gaining better understanding overload use theory lyapunov system stability characterize stabilizing overload control schemes state space representation server simple lyapunov function utilized build proportional integral derivative pid controller performing overload control tandem system servers proposed pid overload control algorithm evaluated using experiments showing successfully restore throughput close maximum system capacity overload furthermore study effect overload detection lag system stability showing even small delay overload system stabilization multiple minutes elsevier rights reserved
present study examined impact reputation information athletes behavioral responses within naturalistic field based setting using group design male soccer players assigned one three experimental conditions experienced reputation reputation reputation prior taking part coaching session delivered unknown participants behaviors indicative attention instruction effort persistence willingness participate video recorded throughout coaching session multivariate analyses variance revealed participants experienced reputation condition exhibited significantly greater attention instruction greater effort persistence free practice participants reputation condition results related participants willingness participate failed yield significant differences results provide evidence support athletes use reputation information basis initial potential influence athletes behavior athlete interactions findings also indicate based positive information powerful negatively framed means developing effective relationships athletes
aim present study evaluate inflammatory oxidative stress blood markers possible predictors multiple sclerosis clinical forms study included patients relapsing remitting progressive clinical forms healthy individuals peripheral blood samples obtained determine serum levels albumin reactive protein crp total protein lipid butyl initiated carbonyl protein content advanced oxidation protein products nitric oxide metabolites nox total radical trapping antioxidant parameter trap patients showed higher lower albumin trap nox values controls difference observed crp total protein carbonyl proteins patients controls logistic regression age adjusted showed positive association predictors development respectively albumin trap nox negatively associated respectively moreover logistic regression age adjusted showed patients progressive clinical forms lower albumin higher conclusion albumin biomarkers trap nox predictors diagnosis whereas albumin predictors differentiated progressive clinical forms
suppress noise effectively become one key problems remote sensing image processing problem also development key technology severely especially military applications overcome optimal solution image based sparse representation one one mapping original signal space paper propose novel synthetic aperture radar sar image via sparse representation domain based continuous cycle first transform applied sar image second new optimal model constructed using sparse representation model based cycle theory finally alternate iteration algorithm used solve optimal model obtain image experimental results show proposed method effectively suppresses noise improves peak signal noise ratio sar image also obviously improves visual effect sar image especially enhancing texture sar image
modifications rna diverse ubiquitous amongst eukaryotes occur mrna rrna microrna recent studies revealed reversible rna modifications affect rna splicing translation degradation localization multiple physiological processes like circadian rhythms stem cell fibrosis triglyceride metabolism obesity also controlled modifications immunoprecipitation sequencing mass spectrometry modified northern blotting methods commonly employed measure modifications herein present northeastern blotting technique measuring modifications current protocol provides good size separation rna better standardization various experimental designs clear modifications various sources rna modifications known crucial impact human physiology relating circadian rhythms obesity roles physiological states unclear therefore investigations modifications immense possibility provide key insights molecular physiology
background thyroid autoimmunity major risk factor gestational thyroid disease recently various risk factors identified including maternal age body mass index bmi parity human important determinant gestational thyroid function yet unknown extent differences concentration affect risk thyroid disease recently shown antibody positivity impairs response stimulation suggest mechanism thyroid autoimmunity acts risk factor thyroid disease objective purpose study determine whether risk factor thyroid disease entities whether recently identified risk factors thyroid disease influence response stimulation methods human thyrotropin tsh free thyroxine measured pregnant women participating prospective cohort association thyroid disease entities association known risk factors response stimulation studied using multivariable linear regression models results higher concentrations associated higher risk subclinical overt hyperthyroidism lower concentrations associated higher risk contrast concentrations associated subclinical hypothyroidism analyses showed women high concentrations still suppressed tsh however women subclinical hypothyroidism high concentrations associated higher higher bmi male fetal sex maternal parity associated lower response stimulation conclusions human associated risk subclinical hyperthyroidism risk subclinical hypothyroidism women normal response stimulation abnormal women subclinical hypothyroidism known risk factors thyroid dysfunction bmi parity also male fetal sex associated lower response stimulation
paper consider inhomogeneous fifth order nonlinear schrodinger equation variable coefficients describes dynamics site dependent ferromagnetic spin chain darboux transformation constructed one two soliton solutions represented virtue lax pair give infinite number conservation laws furthermore graphically analyze influence perturbation terms inhomogeneous parameters soliton propagation interactions perturbation terms found induce phase shift soliton affect soliton amplitude inhomogeneous parameters lead increasing decreasing process soliton amplitude change propagation direction perturbation terms inhomogeneous parameters also affect soliton interactions elsevier rights reserved
paper uses documents generated discuss economic transformation former impact spanish administrative policies implemented early diverse social environmental landscapes rural areas lying west provide range local case studies reveal settlement policies failed produce sustainable detailed records indigenous land area show gender status based patterns individual ecological differences communities local records indicate continuing importance era community identities local leadership maintaining community contrast documents related among private reveal vast inequalities land access rapid growth demand indigenous labor produce important argue spanish administrative policies accelerated transformation means production rural creating instead indian subjects
children experienced repeated event reports experienced details reported across multiple interviews experiments explored consistency childrens reports instance repeated event long delay age years age years age years experiments children either experienced activity sessions followed relatively short delay days weeks initial memory test following longer delay months year children memory questions analyzed consistency childrens memory reports across interviews accuracy defined narrow broad criteria highly consistent pattern observed across experiments children experienced single event appearing consistent children experienced repeated event conclude inconsistencies across multiple interviews expected children experienced repeated events inconsistencies often reflective accurate different recall
forty healthy geriatric years initially fed control food day pre feeding period blocked age gender body fat percentage dogs randomly assigned foods experimental food royal mature medium breed dog senior senior maintenance month testing period blood chemistry evaluated changes kidney health body composition day body weight increased dogs fed food tended dogs fed food food lost lean day period dogs fed food also gained fat foods maintained fat addition dogs fed food gained bone mineral content dogs fed food lost dogs fed foods higher blood urea nitrogen levels dogs fed food creatinine ratio dogs fed foods elevated ratios compared dogs fed food dogs fed food greater percentage animals reduced kidney function indicated analysis compared dogs fed food conclusion geriatric dogs fed experimental food reduced protein phosphorus showed less progression kidney disease compared commercial geriatric foods addition dogs fed experimental food maintained lean bone mass compared commercial formulations
based science technology society teaching framework ubiquitous situated learning system developed study using emerging man machine interaction technologies quick response codes code teach science technology society aspects smart green buildings teaching experiment statistical analyses conducted explore connections among subjects sex prior knowledge levels scores time spent completing confidence knowledge smart green buildings perceived usefulness system learning interest subjects study junior students department architectural design university taiwan twenty six male female according analysis results use system help significantly improve students learning results regardless differences prior knowledge levels addition interactive learning provided system accepted students help students effectively improve test scores knowledge confidence learning interest
construction management china new practice encompassing evaluation criteria green construction thus greenhouse gas emissions produced construction period overlooked greenhouse gas emissions construction projects evaluated based life cycle assessment theory green construction evaluation management techniques procedure assessing greenhouse gas emissions construction projects developed using unit construction process classifying integrating different components construction projects segregation integration method established calculating greenhouse gas emissions construction project mathematical model framework calculate greenhouse gas emissions construction projects established energy consumption carbon dioxide emissions foundation work reinforced concrete construction calculated based example commercial building large scale residential complex new district city greenhouse gas emissions calculated equivalent carbon dioxide emissions high rise buildings highest unit carbon emissions carbon dioxide emissions produced construction residential community unit carbon emissions construction entire residential community approximately scientific value paper carbon emissions construction stage residential community quantitatively assessed unit carbon emissions buildings construction used calculate unit energy consumption buildings construction useful energy savings therefore provide management guidance reducing energy consumption life cycle building especially consumption construction elsevier ltd rights reserved
building integrated photovoltaic wall system provide heating cooling generate electricity simultaneously studies wall system focused two major types one cells attached glass attached mass wall characterized low thermal electric efficiency study presents blind integrated wall system adopting developed models optimum blind angles three seasons summer winter mid term seasons time day investigated comparative assessment three wall systems conducted year round weather conditions terms thermal electrical performance results illustrated annual electricity output system similar system times system system superior systems cooling load reduction using heating load decreased significantly compared using combining electricity generation cooling heating load reduction total electricity saving system higher compared systems emissions reduction system times systems elsevier ltd rights reserved
paper shows example computer simulation hybrid vehicle two different driving modes example shows multiple areas operation simulated hybrid electric vehicle hybrid electric vehicle combined type similar cars hybrid electric vehicle two types driving power electric motor internal combustion engine increase level efficiency driving assembly reduce air pollution hybrid electric vehicle combines advantages electric motor drive pollution high available power low speeds advantages engine high dynamic performances little pollution high speeds simulation hybrid electric vehicle matlab used
global fight rapidly changing situations raise hot debates urgently needed new designs operational modes efficient low cost jet engine expected roles future unmanned carrier launched surveillance current unmanned combat air vehicles failed perform needed role jet engine community rapidly situation reviewed main text
propose taxonomy psychopathology based patterns shared causal influences identified review multivariate behavior genetic studies distinguish genetic environmental influences either common multiple dimensions psychopathology unique dimension phenotypic level first order dimensions defined correlations among symptoms correlations among first order dimensions similarly define higher order domains internalizing externalizing psychopathology hypothesize robust phenotypic correlations among first order dimensions reflect hierarchy increasingly specific influences nonspecific factors increase risk first order dimensions psychopathology varying degrees general factor psychopathology nonspecific factors increase risk first order dimensions within specific higher order domain furthermore first order dimension unique causal influences genetic environmental influences common family members tend nonspecific whereas environmental influences unique individual dimension specific causal influences psychopathology moderated sex developmental processes causal taxonomy also provides novel framework understanding heterogeneity first order dimension different persons exhibiting similar symptoms influenced different combinations influences levels hierarchy furthermore relate proposed causal taxonomy processes also impact heterogeneity psychopathology dimension causal taxonomy implies need changes strategies studying etiology prevention treatment psychopathology
study provides understanding influence outside temperature buildings urban landscape derive heating cooling degree days buildings identifying appropriate choice balance point temperatures perform multiple linear regression characterize temperature electricity use relations study reveals considerable differences temperature electricity relationships based building use characteristics addition outside temperature effect large influences electricity consumption buildings summer months greater influence outside temperature electricity consumption followed transition months winter increase one cooling degree day increases daily electricity consumption whereas winter one heating degree day increases daily electricity consumption transition months apply two kinds models project electricity demand projected temperature profiles cases strongly suggest higher electricity demand just summer months also transition periods spring fall overall electricity demand increases low emission scenario high emission scenario likely put immense pressure united states electric grid system overall increase energy cost elsevier rights reserved
saccharomyces cerevisiae established model organism used study multiple facets eukaryotic organisms manipulation isolation dna key element basic genetic research meanwhile isolation rna required study transcriptional regulation presented chapter fast efficient methods genomic plasmid dna total rna capable utilized variety genetic studies restriction analysis northern southern blotting real time reverse transcriptase pcr plasmids isolated via method also sufficient quality transformed coli genetic manipulation study
considering value water high cost acquisition distribution goal oriented utilization water resources necessary one problems water resources development developing countries low yield use water irrigation networks downstream dams despite vast investments construction networks iran enough attention paid right method operation guarantees success achievement primary goals networks construction therefore irrigation networks operated experimental methods without scientific planned basis considering complex hydraulics water distribution open networks extensive infrastructures studying aim determination suitable reliable operation method possible physical tests laboratories experimental approaches mathematical models utilized present study hydrodynamic model employed provision suitable operation method irrigation network located downstream dam iran best operation scenario based water distribution assessment indicators offered model vast study available scenarios present operation method water distributed network steady distribution fixed discharge proposed method water distributed distribution variable discharge days provide water requirement present cropping pattern elsevier rights reserved
recent research shown memory successfully prime childrens adults performance complex insight based problems compound remote associates tasks current research aimed clarify locus priming effects like deese roediger mcdermott drm lists selected prime subsequent critical lures also solution words subset participants attempted solve unique present research recognition memory tests used participants either primed list study phase memory test phase across two experiments primed problems solved frequently significantly faster problems moreover participants primed list study phase subsequent solution times rates considerably superior produced participants simply primed test together first results show false memory priming encoding facilitates problem solving children adults
although dysregulation dopaminergic system generally considered central addiction involvement circuits increasingly appreciated interaction locus neurons posterior ventral area dopaminergic system processing drug triggered reward suggested demonstrated animals herein try precise role neurons circuit mediating reward reinforcement behavior associated ethanol standard two active inactive paradigm rats trained self ethanol subjected pharmacological intervention intra administration alpha agonist increased ethanol self administration agents reduce tone produced opposite effects degeneration ethyl dsp intraperitoneal route silencing via intra route neurons decreased via intra route ethanol self administration furthermore reduced ethanol self administration effect fully attenuated given directly suggests feedback signals necessary sustain ethanol self infusion activity ethanol self administration significantly increased tyrosine hydroxylase immunoreactivity response blocked dsp pre treatment dopamine receptors localized neurons pre treatment intra press activity suggest two way communications regions essential ethanol triggered reinforcement behavior
authors present viewpoint regarding quality data used estimating number preventable hospital deaths united states data derived countries healthcare system defined near uniform implementation standards applicable fragmented delivery system found united states although studies evaluating preventable mortality based projections small sample size unlikely observation due chance studies evaluating adverse events precursor preventable mortality much larger sample size also report high number events addition although estimates involved adult medicare eligible patients higher incidence events create bias also capture events taken account mortality occurs hospitalization also important mitigate adverse events patients whose death medicine moral authority place differing values days weeks years life approximately preventable hospital related deaths year united states hospital systems united states make investment patient safety recently agency healthcare research quality demonstrated decline adverse events hospitals uniform implementation safety standards takes place healthcare system whole lag behind nations
growing interest scientific community production activated carbon using potential sustainable precursors biomass wastes physical activation chemical activation main methods applied activation process methods significantly beneficial effects chemical physical properties make suitable multiple applications including water pollution treatment capture energy storage different compositions conditions activation parameters significant influences properties resultant activated carbon compared traditional activated carbon activated appears new potential cost effective environmentally friendly carbon materials great application prospect many fields review summarizes information current analysis activated multiple applications optimization understanding also offers new directions development activated elsevier ltd rights reserved
obesity known major contributing risk factor knee osteoarthritis also believed obese knee arthroplasty patients tend poorer outcome possible early failure purpose study investigate early outcome obese patients single institution patients underwent fixed bearing medial year included study divided four groups based body mass index bmi control overweight obese severely obese functional outcome assessed using knee society score knee score short form one way anova bonferroni post hoc test used compare four groups quantitative variables patients study significant difference four bmi groups gender side operated knee functional outcome four groups years comparable mean follow range years revision surgeries identified mean duration initial surgery revision surgery months range patients pre operative bmi influence early outcome patients however patients higher bmi relatively lower functional score prior surgery tended younger translate early failure functional improvement similar among four groups
current study tested whether participants played violent video game exhibit increased aggressive relative played non violent video game participants randomly assigned play prior presumably interacting another non existent participant measured participants aggressive participants reported many like representing interaction partner participants reported likely actually harm interaction partner detect differences conditions several outcomes amount aggressive displayed interaction number participants chose representation interaction partner participants self reported likelihood harm interaction partner thus hypothesis playing increase aggressive supported study exploratory analyses revealed associations participants self reported likelihood perceptions game difficult gender higher levels pin selection participants self identification lower levels pin selection elsevier inc rights reserved
brief presents integrated optimization framework battery sizing charging road power management plug hybrid electric vehicles framework utilizes convex programming assess interactions three optimal design control tasks objective minimize carbon dioxide emissions board internal combustion engine grid generation plants providing electrical recharge power impacts varying daily grid trajectories optimal battery size charging power management algorithms analyzed find level grid emissions significantly impact nature emission optimal road power management also observe road power management strategy important design task minimizing emissions variety comparative studies
introduction documented black hispanic dialysis patients overall lower risks death white dialysis patients little known whether lower risks observed cause specific deaths additionally recent research reported younger black patients higher risk death source unclear therefore study examined cause specific deaths among dialysis patients race ethnicity age methods national study included incident dialysis patients united states renal data system five cause specific mortality rates including cardiovascular cvd infection malignancy known causes unknown compared across whites overall stratified age groups findings multiple adjustments hispanic patients lowest risk mortality every major cause almost ages compared whites lower risk death cvd malignancy causes age groups infection fact higher risk infection death whites ages years years years partially attributed higher prevalence aids nephropathy race ethnicity two thirds infection deaths due non dialysis related infections discussion lowest risk major cause death less likely die whites causes except infection previously reported higher overall mortality rate younger attributed two fold higher infection mortality mostly non dialysis related suggesting new direction improve overall health status research greatly needed determine social biological factors account survival gap dialysis among different racial ethnic groups
hormone oxytocin plays important role attachment formation bonding humans domestic dogs recent research led increased interest potential applications intranasal oxytocin aid treatment psychological disorders humans studies explored effects administered oxytocin social cognition social bonding dogs alternative applications yet explored treatment behavioural problems species one potentially important application intranasal oxytocin dogs treatment separation anxiety common attachment disorder dogs provide overview known role oxytocin human dog bond canine separation anxiety discuss considerations future research looking integrate oxytocin behavioural treatment based recent findings human dog literature
individuals act climate change widely assumed emphasizing personal responsibility climate change effective increasing pro climate behavior whereas collectively framing causes climate change responsibility incentive individual action observe opposite result find across three experiments emphasizing collective responsibility causes climate change increases pro climate monetary approximately environmental group members general public highlighting collective responsibility intent reduce future carbon emissions contrast focusing personal responsibility climate change significantly alter climate change advocacy intent future pro climate behavior effects replicate persist multiple days treatment
background rate lost time sprains strains private nursing homes three times national average back injuries almost four times national average workers compensation sponsored interventions preferentially promoted nursing homes including training consultation equipment methods study evaluated impact interventions back injury claim rates using data claims interventions nursing homes using poisson regression subset nursing homes analyzed detailed data allowed estimation impact levels resident claim rates costs interventions compared associated savings claim costs results equipment purchase per nursing home worker associated reduction back injury rate assuming equipment lift years translates estimated reduction claim costs per worker present value rate applied results training courses receiving median hours significant reduction claim rates injury rates generally decline consultation independent equipment although possible confounding bias due non random management participation clouds interpretation nursing homes available data resident modestly associated back injury risk injury rate increased resident staff ratio acting three terms additional resident per staff member ratio alone expenditure per resident care worker equivalent per employee model also associated reduction injury rate however resident staff ratio greater expenditure associated reduction back claim costs years per employee present value rate conclusions expenditures equipment nursing homes associated fewer worker injuries reductions claim costs similar magnitude expenditures estimated benefits costs also need considered assessing full health financial impacts med wiley liss inc
paper concerns dynamical decoupling feed forward control planar actuators moving coils moving stages center mass geometric center based direct current decoupling factors affect continuity current analyzed stable current control propulsion works converted newton euler dynamic equation inverting system dynamics degrees freedom dof individual control realized system simplified mimo based decoupling acceleration feed forward controller pid control designed studying coupling parameter relating feed forward inputs white noise acceleration amplification coefficient achieved pid parameters optimized based comparing actual variance minimum achievable variance last simulation results indicate feed forward compound controller applying system better performance general pid controller
paper multi scale numerical simulation method used simulate dynamic behaviors nano void metal shock loading method couples molecular dynamics method used local defect domain finite element method used globally using bridge scale function based calculated strain field temperature field atom positions reveal collapse nano void depends yield strength materials shock loading strength compression process void main reason formation local hot spot meanwhile dislocation hot spot induced void collapse lead easy formation local shear band
charge sharing fractional collection charge cloud generated detector two adjacent pixels lead excessive inefficient registration comparing number depending discrimination thresholds set typical photon counting pixel detector problems particularly exposed fine pixel sizes thick planar detectors presence charge sharing one limiting factors decreasing sizes pixels photon counting mode ray radiation imaging systems currently different approaches tackling charge sharing problem exist general idea first reconstruct entire signal adjacent pixels secondly allocate hit single pixel paper focuses latter part process comparison different hit allocation algorithms affect spatial accuracy false registration missed hit probability different hit allocation algorithms simulated including standard photon counting full signal reconstruction algorithm also novel approach based detection patterns significantly limited analog signal processing proposed characterized
change points variations time series data changes represent transitions occur states detection change points useful modelling prediction time series found application areas medical condition monitoring climate change detection speech image analysis human activity analysis survey article compares many methods proposed detect change points time series methods examined include supervised unsupervised algorithms introduced evaluated introduce several criteria compare algorithms finally present challenges community consider
relationships victimization termination pregnancy top diagnosis sexually transmitted infection emergency contraceptive use examined using data survey university students canada female students sexually active past two years least one male partner included victimization experiences assessed logistic regressions performed predict correlates lifetime use emergency contraception top ever diagnosed sample reported intimate partner violence ipv reported sexual assault reported ipv factors statistically associated emergency contraceptive use top diagnosis older age financial migratory trajectory early sexual initiation dual victimization data indicate reproductive health needs female university students experiencing victimization unmet interventions focus victimization screening enhancing reproductive autonomy
three experiments examined impact excessive violence sport video games aggression related variables participants played either simulation based sports video game football matched violent sports video game participants completed measures assessing aggressive cognitions experiment aggressive affect attitudes towards violence sports experiment aggressive behavior experiment playing violent sports video game increased aggressive affect aggressive cognition aggressive behavior attitudes towards violence sports games competitive findings indicate violent content uniquely leads increases several aggression related variables predicted general aggression model related social cognitive models elsevier inc rights reserved
background corticosteroid treatment established first anti inflammatory treatment adults children asthma however subset patients fails respond combined systemic inhaled treatment objective study aimed understanding resistance among children severe asthma methods high resolution metabolomics performed urine samples children determine possible urine biomarkers related resistance metabolic phenotypes responders analyzed using bioinformatics including plot false discovery rate hierarchical cluster analysis genes genomes pathway analysis results way hierarchical cluster analysis study determined metabolites showing significantly different levels responders important metabolites annotated acid ethylene glycol gamma reduced nacl tyrosine metabolism degradation aromatic compounds glutathione metabolism suggested significant pathways relating resistance conclusions high resolution metabolomics promising approach asthma research five candidate markers identified related resistant children severe asthma compounds upon validation contribute understanding resistance among children severe asthma use
mutant mediated aberrant signaling pathway hallmark myeloproliferative neoplasms mpns although cytokine inducible homology protein cis cytokine signaling negative regulators jak stat pathway functional role cis family members mutant induced oncogenic signaling pathway yet elucidated study found expression cis induced activation signal transducer activator transcription cells stimulated also cells transformed mutant cell proliferation tumor formation mice induced mutant significantly enhanced expression cis using rna interference technique whereas knockdown effect expression cis caused apoptotic cell death transformed mutant drastically inhibited mutant induced tumor formation cis interacted phosphorylated critical activation erk whereas activation erk transformed cells mutant increased knockdown cis expression cis reduced activation molecules furthermore anti tumor effects cis required function domain tyrosine phosphorylation herein elucidated mechanism cis functions novel type tumor suppressor mutant induced tumorigenesis elsevier inc rights reserved
objective recent research demonstrated strong relationship psychotic experiences suicidal behaviour research date however investigated role borderline personality disorder bpd relationship despite fact bpd highly comorbid common mental disorders associated recurrent suicidal behaviour psychotic experiences paper examined relationship psychotic experiences suicide attempts including bpd common mental disorders method used adult psychiatric morbidity study stratified multistage probability sample households england recruited nationally representative sample aged years older participants assessed common mental disorders bpd clinical subclinical suicidal behaviour psychotic experiences results approximately total sample reported psychotic experiences psychotic experiences associated increased odds suicide attempts individuals bpd individuals common mental disorder individuals without common mental disorder individuals neither common mental disorder bpd conclusion psychotic experiences associated high odds suicidal behaviour individuals without psychopathology relationship explained clinical subclinical bpd
distinctive encoding greatly influenced based processes shown suffer highly similar items presented close thus elucidating mechanisms underlying presentation format affects processing essential determining factors influence encoding processes current study utilised multivariate partial least squares analysis identify encoding networks directly associated retrieval performance blocked presentation condition subsequent memory analysis successfully encoded items indicated significant differences reaction time retrieval performance presentation format despite significant behavioural differences behaviour revealed differences brain behaviour correlations mean condition activity brain regions associated based distinctive encoding specifically format encouraged distinctive encoding showing increased activation regions associated strategy use visual processing frontal visual cortices respectively alternatively blocked format exhibited increased based processes accompanied increased activity right inferior frontal gyrus together results suggest sequence information presented encoding affects degree distinctive encoding engaged findings extend understanding fuzzy trace theory role presentation format encoding processes
exposures particulate matter diameter less influence risk birth defects make allergic causes serious harm human health harmful substances peoples health order figure optimal condition intrinsic change five chemicals analyzed optimal blast time min min min min min min spectra showed five characteristic peaks sas respectively peaks achieved maximum min peaks achieved maximum min peaks achieved maximum min peaks achieved maximum min peaks achieved maximum min peaks achieved maximum min proved remove sulfur powder air sulfur allergies authors production hosting elsevier behalf university
three dimensional zno materials synthesized top graphene layer using facile cost effective hydrothermal growth method graphene zno demonstrated efficient alternative standard doped tin oxide zno based dye sensitized solar cells due larger surface area better charge transport characteristic higher electrochemical activity addition graphene nanostructures also revealed efficient replacement conventional counter electrode exploiting synergy components power conversion efficiency demonstrated simulated solar radiation elsevier rights reserved
multi population method widely used solve continuous dynamic optimization problems aim maintaining multiple populations different peaks locate track multiple changing peaks simultaneously however make approach efficient several crucial challenging issues need addressed determine moment react changes adapt number populations changing environments determine search area population addition several issues communication populations overlapping search way create populations detection changes local search operators also addressed lack attention challenging issues within multi population methods hinders development multi population based algorithms dynamic environments paper challenging issues comprehensively analyzed set experimental studies algorithm design point view experimental studies based set popular algorithms show performance algorithms significantly affected challenging issues moving peaks benchmark elsevier inc rights reserved
background hereditary angioedema inhibitor deficiency inh hae characterized recurrent attacks swelling affect various body sites attacks frequent cause visits emergency department often treated hospital recent years self administration inhibitor inh concentrates home become increasingly used option positive impact patient outcomes quality life methods observational study months duration patients inh hae referred hae center southern italy patients received three types treatment swelling attacks inh concentrates administered home administered home inh concentrates administered hospital objectives observational study compare therapy compliance defined proportion treated attacks quality life home hospital treated patients identify factors associated decision use home therapy results overall attacks reported months treated total number reported attacks mean number attacks per patient respectively three groups home based inh home based hospital based inh differences attack frequency home hospital based treatments statistically significant patient demographic characteristics disease severity score correlate use home therapy compliance therapy significantly better home based therapy treated attacks inh hospital based therapy quality life showed opposite trend patients hospital based treatment reporting highest quality life conclusions home based therapy associated better compliance compared hospital based therapy choice adopt home based therapy appeared correlate high attack frequency home based therapy valid treatment option patients inh hae offered patients especially high attack frequency
recently wireless charging via magnetic resonance coupling gained attention potential efficient wireless charging functions sensing transmitter wireless communication target essential elements realize standard wireless charging system currently sensing communication protocol hardware high frequency power source antenna configuration compatible wireless charging gaining attention terms cost space reduction due use common components multiple functions however protocol problem narrow effective areas due fact sensing range depends fixed factor antenna overcome problem concept wide area sensing based controllable antenna proposed effectiveness verified theoretical analysis experiment result clarified effective area expanded ratio distance transmitting receiving antennas inner diameter antenna wiley periodicals inc
treatment response follicular lymphomas highly variable therefore investigated role cancer associated fibroblasts tumor cell viability particular response treatment cytotoxic drugs stromal cells patients characterized pure populations cultivated cells analyze fibroblast mediated effects cells culture treated cell population positive markers tested showed increased mrna expression activation marker effect cell viability noted however stromal cells protected tumor cells apoptosis response cytotoxic treatment explained mrna induction regulation cells finding protective mechanisms mediated pivotal impact studies cytotoxic agents
exam images useful identify diseases colorectal cancer one common cancers worldwide computational image analysis machine learning techniques assist experts identify abnormalities images work present evaluate aims help experts study analyze colon tissue images system initially extracts features images currently laws texture descriptors supported described images classified normal abnormal images version nearest neighbor based multilayer naive bayes support vector machine classification algorithms implemented developed open source technologies using software engineering approach improve flexibility work quantitatively assessed application set tissue image fragments classifiers built set compared according cross validation contingency table strategies also system qualitatively evaluated using heuristics twelve volunteers health exact sciences issues found categorized according severity scale result classifier achieved highest sensitivity reasonable average error qualitative evaluation issues found considered serious assessments suggest useful assist domain experts minimum knowledge informatics conduct complete studies medical images identifying patterns regarding different abnormalities published elsevier ltd
papillomavirus hpv positive cancer generally associated excellent response therapy hpv positive tumors progress despite aggressive therapy purpose study evaluate viral oncogene expression viral integration sites positive squamous cell carcinoma lines alternate transcripts assessed reverse transcriptase polymerase chain reaction pcr detection integrated papillomavirus sequences pcr sequencing identified viral insertion sites affected host genes cellular gene expression assessed across viral integration sites hpv positive cell lines expressed alternate splicing indicative active viral hpv integration occurred within cancer related genes head neck squamous cell carcinoma lines scc integration integration cancer related genes occurred hpv positive cell lines tumors progressed hpv integration cancer related genes secondary carcinogenic driver hpv driven tumors wiley periodicals inc head neck
present methodological integrating findings quantitative qualitative review topic provide insight components care contribute supportive care acceptable men prostate cancer prostate cancer likely live long time disease experience side effects treatment therefore ongoing supportive care needs quantitative qualitative reviews published findings yet integrated quantitative qualitative synthesized evidence data previously published systematic reviews review evidence supportive care men prostate cancer integrated two previously published systematic reviews narrative quantitative review qualitative review thematic synthesis two streams synthesized evidence synthesized using concurrent narrative summary data reviews used develop set summary components care likely contribute supportive care acceptable men prostate cancer identified developed covered mens supportive care focusing role health professionals used nine components care likely lead supportive care acceptable men prostate cancer components low cost developing empathic personalized approach specific approaches need investigation randomized controlled trials example online support methodological demonstrates integration quantitative qualitative synthesized data determine components care likely lead provision supportive care acceptable men prostate cancer
integration glass microfluidic flow configuration demonstrated parallel production scale droplets system supports generation continuous stream single phase dual phase droplets digital control droplet content enabling formation dynamically programmable tunable capillary method allows simultaneous generation multiple droplets parallel droplet generators controlled switching selected dispersed phase continuous phase compositions individual phases emerging capillary outlet selected yield merged droplets combining continuous phase emitted one neighboring droplet generators capillary configured two dimensional array system provides greater flexibility toward producing controlled interactions multiple solutions phases conventional planar microfluidic droplet generators using capillary configuration ability regulate droplet composition particle size individual combined single merged water oil droplets explored together use two dimensional spatial control within array generate higher order elsevier rights reserved
self interested moves manipulation interpersonal relationships parties inside outside workplace constitute serious concern management often directly ethical failures generic individual differences linked use like approaches match immediate cultural social environment external locus control beliefs indirect influences inducing foster self interested decisions prompting strict moral codes study investigates potential mechanism relate negatively ethical work intentions results obtained sample employees spain reveal external locus control beliefs relate positively mediates negative influence inducing ethical work intentions study thus provides novel information managers interested reducing employees tendencies offers appropriate strategies work behaviors elsevier ltd rights reserved
fluorescence activated cell sorting technique specific cell populations based phenotypes detected flow cytometry method enables researchers better understand characteristics single cell population without influence cells compared methods cell enrichment magnetic activated cell sorting flexible accurate cell separation due ability phenotype detection flow cytometry addition usually capable separating multiple cell populations simultaneously improves efficiency diversity experiments although limitations broadly used cells functional studies vitro vivo settings report protocol using fluorescence activated cell sorting isolate rare population immune cells dendritic cells high purity bone marrow lupus prone mice vitro functional studies
present results analyzing physical morphological properties transient holes associated mass processed semi automated tracker using solar dynamics observations instead typically used difference images used hole detection algorithm detect transient dark regions directly extreme ultraviolet images allowed study contrast larger diffuse seen difference images represent projected view rising expanding plasma studying morphology allowed better understand structure low comparing physical properties also able identify relationships different parts complex phenomenon found larger longer lived suggesting takes longer close large open magnetic regions also growth phase smaller acquire higher magnetic flux imbalance become larger furthermore found intensity indicative local electron density correlates much plasma removed energetic studying morphology single double fragmented also helped identify different configurations quasi open magnetic field
dysfunction emerges early alzheimers disease contribute pathology progression recently voltage gated potassium channel subunit underlies fast currents recognized relevant pathogenesis emerging new target candidate present study investigated vitro vivo models expression functional activity potassium channel subunits astrocytes primary astrocytes biochemical immunohistochemical electrophysiological studies demonstrated time dependent upregulation expression functional activity exposure amyloid beta consistently expression upregulated cerebral cortex hippocampus cerebellum month old mice confocal triple labeling studies revealed month old mice beta associated astrocytes interestingly cortical hippocampal regions month old mice plaque associated astrocytes much expressed subunits beta important evidenced selective knockdown expression significantly downregulated glial acidic protein levels beta brain month old mice collectively results demonstrate expression function channel subunits upregulated cultured astrocytes exposed beta reactive astrocytes mice elsevier inc rights reserved
recent advances investigation myeloproliferative neoplasms mpn impact genetic heterogeneity molecular pathogenesis fully elucidated thus study aim characterize genetic complexity korean patients polycythemia vera essential thrombocythemia methodswe conducted association studies using single nucleotide polymorphisms snps patients controls whole genome sequencing performed six patients two four wild type putative somatic mutations validated patients clinical laboratory characteristics also analyzed germline snps haplotype significantly associated three somatic mutations calr genes selected validated frequency calr mutation patients carry mpl mutations moreover compared positive patients calr mutations showed lower hemoglobin levels respectively higher platelet counts lower frequency therapy study first comprehensive investigation genetic characteristics korean patients found somatic mutations haplotype contribute pathogenesis korean patients
prenatal stress lasting effect womens mental health negative effects particularly salient women low income ethnic minority backgrounds increased risk postpartum depression however social support potential attenuate negative impact stress present study evaluated mexican american women ages spanish speaking median income prenatal stress daily family stress partner stress culture specific stress relation depressive symptoms weeks postpartum prenatal social support examined buffer impact prenatal stress partner stress family stress daily uniquely predicted depressive symptoms moderate high levels social support attenuated risk depression due family stressors prenatal interpersonal daily stressors negatively impact mental health women birth social support mitigate effects among mexican american pregnant women effective interpersonal support stress management associated reduced risk postpartum depression
paper presents development wireless flow transmitter using operational amplifier based signal conditioning circuit linear gravity based flow measuring device consists display unit directly displays flow rate industrial applications new circuitry required transmit measured flow rate control unit remote areas ferromagnetic wire attached acts core inductance coil constitutes flow sensor self inductance coil changes according change flow rate operational amplifier based circuit used measurement self inductance voltage corresponding flow rate finally converted current wireless readout provided using microcontroller unit module results show linear relation variation self inductance coil transmitter output respect flow rate theoretical equations simulation results added paper
paper presents results large scale numerical modeling cellular reinforced fly ash beds soft clay using finite element program cellular structure consisting interconnected multiple circular cells influence height diameter tensile stiffness cell width entire pressure settlement response surface deformation settlement mobilization tension cell walls illustrated results numerical analyses indicate improvement capacity times greater fly ash bed inclusion single geotextile representing geotextile fly ash bed underlying clay cellular fly ash composite bed produced approximately increment capacity compared unreinforced fly ash bed presence reinforced beds produced better capacity increase height width tensile stiffness cell wall satisfactory acquire optimization height width tensile stiffness cell wall particular width height capacity increased reduction cell diameter cell center maximum tension lesser cells successively toward periphery also tension increase tensile stiffness cell wall small scale finite element models created using material models properties used large scale modeling validate program laboratory small scale model tests comprising model conditions finite element results found good agreement experimental results
soluble receptor advanced end products toxic ages considered protective factor study aimed evaluate correlation levels clinical outcomes women young advanced maternal age undergoing vitro fertilization total young women women undergo included prospective study concentration measured determine association number retrieved high quality embryos achievement clinical pregnancy young women respectively besides correlations age follicle stimulating hormone fsh examined found levels higher young patients patients suggesting levels inversely correlated age young patients showed correlation number retrieved high quality embryos achievement clinical pregnancy found patients retrieved high quality embryos demonstrated higher levels prognostic factor getting clinical pregnancy independent age fsh level conclusion levels decrease age elevated levels indicate good follicular growth fertilization embryonic development successful clinical pregnancy women young women role predominant
present innovative image based modeling technique based google earth like algorithms effectively resolve intricate material morphology address computational complexity associated heterogeneous materials sharp volumetric algorithm stems volumetric method multi resolution modeling strategy computer graphics work enhance volumetric filter reconstruct statistical information heterogeneous systems hierarchy microstructures created high energy ball composites analyze first second order statistics microstructures characterize macro micro mechanical material responses furthermore conduct convergence study associated computational results statistical mechanical robustness data compression demonstrated corresponding error analysis elsevier ltd rights reserved
ambient assisted living technologies potential target challenges aging population however little known motivates older adults adopt new technologies research area relies single cases specific application limited number users fill gap content analyses reports conducted aim provide comprehensive overview potential incentives using technologies data coded using social cognitive theory total incentives identified grouped six categories social incentives health safety incentives activity incentives novel sensory incentives status incentives self reactive incentives within categories social health safety important incentives results provide comprehensive theoretically grounded understanding motivates older adults adopt technologies
stress distribution known rotating flow near ground fluid mechanics indicates horizontal aerodynamic particles within dust attributed friction force rather pressure force expression dust emission rate earth theoretically discussed based simulated flow field current understanding physics dust seems transition flow vital dust elsevier inc rights reserved
previous studies shown female attachment insecurity male sexual intimate relationships empirically related however mechanisms involved remain poorly understood study aimed examine two mediating models male sexual concerning first sex chinese college students dating relationships perceived female attachment insecurity mediator male female participants using dyadic data total completed questionnaires provided data respondents recruited sampling students attending colleges five chinas largest cities currently romantic relationship first male female samples perceived female positively correlated violence threat tactics male sample positively correlated emotional manipulation tactics second male sample male partners attachment insecurity anxiety avoidance positively correlated perceived female third male partners attachment anxiety fully mediated relationship perceived female emotional manipulation tactics findings suggest ultimate causes sexual intimate relationships interact implications clinical practice discussed elsevier ltd rights reserved
recent years global photovoltaic market expanded rapidly due sharp decline prices increased attention importance sustainable energy northern one highest irradiance levels world one highest electricity rates latin america conditions one countries several projects developed without government consequently industry experiencing rapid growth paper reviews opportunity take advantage market conditions within residential sector modeling arrays across cities detailed modeling systems performed achieve accurate analysis energy production electricity cost using local resource data optimal array orientation inclination production losses review net net affect value production applied comparison using cost electricity conducted net found better policy choice promote systems net energy injected electrical network paid complete retail rate however developed countries kind policy unlikely supported economic net scheme consumer see advantage energy recorded longer time intervals installing system smaller capacity relative household electricity consumption prevents excess generation injected network utility lower prices retail rate payback periods found low years northern areas high retail rates years areas lower radiation retail rates published elsevier ltd
methyl aspartate nmda receptors fundamental normal function central nervous system cns play important role memory learning activation receptors leads neuronal loss associated major neurological disorders parkinsons disease alzheimers disease schizophrenia epilepsy study novel designed synthesized evaluated nmda receptor antagonists new compounds displayed nmda receptor promising compound showed value order magnitude nmda receptor antagonist clinical use treatment alzheimers disease biological evaluation indicated compound brain permeable determined assay non results indicate one compound potential candidate treatment pathologies associated activation nmda receptors
study compared subjective fracture risks women osteoporosis based estimates patients previous fracture parental hip fracture low femoral score higher age higher bmi likely underestimate risks patients also failed associate risk factors increased risk fractures purpose main objectives explore associations self perceived year fracture risks women osteoporosis risks calculated algorithm identify determinants risk methods carried cross sectional study centers collected data risk factors considered patients estimated subjective year probability major osteoporotic hip fracture numerically percentages also visual analog scale vas compared subjective estimates applied logistic regression analyze determinants risk associations risk factors subjective risk explored using linear probability models results nine hundred seventy two patients included analysis major hip fracture risk average subjective estimates significantly higher respectively correlations subjective measures weak major fracture risk associated single previous fracture parental hip fracture femoral score higher age body mass index better general health state find significant associations subjective risk estimates risk factors except previous fractures conclusions patients fail recognize risk factors fractures thus education patients risk factors beneficial especially elderly low femoral score parental hip fracture history
introduction emergency contraception offers women important strategy prevent unintended pregnancy following intercourse despite constant improvement availability different molecules techniques already existing regimen levonorgestrel intrauterine device emergence ulipristal acetate numbers unintended pregnancies unplanned births still reduced areas covered review evaluate information potential adverse effects tolerability method balance safety effectiveness literature search december performed identify trials studying safety data available concerning expert opinion different means demonstrated generally safe tolerated data support women information order improve use efficacy
majority farmers india crops without using irrigation scheduling criteria consequently application excess irrigation water causes water water resources plant diseases soil salinity lack water results crop water stress present research work automated wireless block sensor network system wsn developed automate irrigation scheduling developed blocks sensors global system mobile module microcontroller unit sensor performed range volumetric moisture content sensors reliable range kpa sensors highly correlated coefficient determination slope small relative root mean square error given soil moisture potential depth microcontroller starts pump soil moisture content reaches field capacity field reaches given threshold field information received user mobile via receiver using text messages system water average
background use electronic health records dental care effect dental care provider patient interaction studied sufficiently authors conducted study explore dental care providers interactions patient visits interactions influence dental care provider patient communication providers patients perception use dental clinic setting patient visits methods authors collected survey interview data patients providers three dental clinics health care system authors used qualitative quantitative methods analyze data obtained patients dental care providers results provider survey results showed significant differences perceptions use patient visits across dental care provider groups dental dental patient survey results indicated patients experienced certain level frustration distraction providers use visit conclusions provider survey results indicated different perceptions across provider groups effect computer use communication patients dental generally reported negative effects communication patients owing computer use interview results also indicated dental care providers feel comfortable interacting without verbal eye contact patients patients dental visit practical implications new design dental locations computer screens within undertaken prevent negative nonverbal communication loss eye contact forcing provider patient back back enhance patient education information sharing
economically relevant pathogen causes vascular several crops including fungal infection usually visualized vascular likely due onset metabolism also seems play crucial role tolerance varieties current work potential function distinct derivatives phenolic compounds tolerance response investigated biochemical analyses ruled key player fungus interaction however changes observed composition higher deposition bound infected stems seemed contribute reinforcement cell walls impairment colonization importantly first time accumulation acid reported stems response vascular fungus activity conjugate demonstrated elsevier rights reserved
conventional integer order proportional integral derivative control almost industrial processes due structural simplicity application fractional calculus field control engineering fractional order pid controllers gaining popularity since requires slight modification integer order pid controller tuning integer order pid controller parameters known techniques like method method etc mostly time domain based frequency techniques also available present research work attempt made tune controller using frequency domain specifications frequency domain specifications considered design includes phase margin specification gain crossover frequency specification robustness gain variations proposed control schemes applied three interacting tank process represented third order system verified servo regulatory servo regulatory response robustness conditions comparison time domain performance indices performed guarantee superiority proposed scheme
introductory information non synaptic transmission sympathetic junctions sympathetic nerve utilizing atp location sympathetic nerves different sites kidney described including renal arteries renal sympathetic nervous control glomerular filtration rate secretion discussed evidence obtained largely experiments animals sympathetic nerve modulation transport water sodium ions collecting duct described finally coverage roles sympathetic nerves renal diseases including hypertension diabetes hypothyroidism elsevier rights reserved
study aimed establish norms modified chinese version autism spectrum rating scale participants recruited shanghai china parents teachers invited complete chinese parent version teacher version versions boys significantly higher sub scale scores total score score points respectively girls age weak correlations sub scores score ranged reached significance correlations appeared stronger common females score based chinese norms ideally correlated score based united states norms boys girls versions norms chinese version children aged years proposed helpful screening individuals autism spectrum disorders general population children
background characterizing associations upper lower airways important asthma management objectives study aimed assess determinants incomplete asthma control patients allergic rhinitis asthma methods multiple factors including age sex atopy smoking history medication use asthma control questionnaire score fraction exhaled nitric oxide rhinitis questionnaire score examined defined rhinitis symptoms sensitization inhaled allergens used subjects incompletely controlled group score controlled group factors contribute incomplete asthma control assessed multivariate analysis results total patients asthma enrolled patients classified incomplete asthma control incompletely controlled group older airflow limitation airway inflammation severe rhinitis symptoms contrast controlled group likely taking nasal corticosteroids multivariate model adjusted age asthma treatment airflow limitation persistence severity rhinitis odds ratio independently associated incomplete asthma control conclusions persistence severity use associated level asthma control patients asthma studies required determine whether appropriate treatment rhinitis improve asthma control american academy allergy asthma immunology
efficient transformation required genetic improvement qualities although transformed particle agrobacterium transformation frequency low study tested new agrobacterium mediated transformation methods using shoot segments combined two different regeneration systems shoot segments cultivated agrobacterium tumefaciens strain harboring binary vector carrying driven promoter maize ubiquitin gene effect different concentrations acid regeneration investigated results indicated medium alpha acetic acid optimal shoot formation nodal stem best shoot induction medium optimal induction direct shoot formation method regenerated per explants positive transgene pcr regeneration method regenerated per explants pcr positive southern blotting confirmed insertion transgene plant host genome direct shoot formation method fold efficient previously reported transformation method species
background schizophrenia often characterized cognitive intellectual impairment however much heterogeneity across individuals suggesting different trajectories illness recent findings shown brain volume differences across subgroups individuals psychosis bipolar disorder intellectual cognitive impairments presented evidence early cerebral disruption cognitive intellectual impairments showed evidence progressive brain abnormalities aim investigate relations cognition intellectual functioning brain structure abnormalities sample compared unaffected individuals methods individuals healthy controls part university schizophrenia data software tool underwent neuropsychological assessment structural magnetic resonance imaging mri individuals divided subgroups according estimated intellectual cognitive performance brain volumes differences investigated across groups results cognitive impairments reduced total brain volume intracranial volume corrected cortical gray matter volume reduced cortical thickness insula volumes cognitive impairment intact showed reduced cortical gray matter volume cortical thickness conclusions data provide additional evidence heterogeneity impairments cognition associated reduced related evidence broad brain structural alterations including suggestion early cerebral disruption contrast impaired cognitive functioning context intact intellectual functioning associated cortical alterations reflect neurodegeneration
longitudinal study aims analyze predictors posttraumatic stress symptoms posttraumatic growth among gender age objective factors disease treatment family environment factors negative sample consisted childhood cancer survivors girls boys aged years remission seven years four years survivors completed set questionnaires including benefit finding scale children university california los posttraumatic stress disorder index regression correlation analyses performed relation proven higher level associated higher levels negative higher level connected higher level warmth parenting female gender older age assessment medical variables severity late effects time treatment completion play significant role prediction influenced factors parenting emotional childhood cancer survivors objective medical data
phase study performed evaluate efficacy safety jak inhibitor ruxolitinib chinese patients ruxolitinib given twice day bid starting dose based baseline platelet count patients achieved reduction spleen size exhibited significant reduction week significant improvement debilitating constitutional symptoms assessed observed patients treated ruxolitinib ruxolitinib treatment generally tolerated chinese patients although treatment associated increase certain adverse events aes established identified risks anemia thrombocytopenia aes considered clinical setting ruxolitinib provided substantial reductions splenomegaly improvements symptoms tolerated chinese patients
negative features false memories frequently false memory research however become increasingly apparent false memories also positive consequences two experiments examined positive consequences false memories participants visually presented false memory word lists received recognition task modified perceptual closure test participants received degraded visual representations words false true unrelated items became time participants identify fast possible based false memories significantly faster based true memories related items roughly similar pattern observed recognition task used critical lures replaced items experiment results indicate false memories beneficial problem solving tasks counter standard perspective false memories inherently negative nature society applied research memory cognition published elsevier inc rights reserved
purpose infection emerging chronic infection immunocompromised hosts aim review discuss pathophysiology infection explore mechanistic models chronic infection state especially patients immune deficiency infection increasingly associated associated primary secondary immune deficiency diseases ongoing debate immune deficiency community whether truly causative agent describe historic aspects infection immunology viral structure basis preventive vaccination also review disease model immune deficiency subjects creates milieu become chronic explore newer disease modification common cause acute general population factors lead persistence patients immune deficiency need holistic studies include host assessment microbiome signatures viral pathogenic factors assessment
view future healthcare sense big changes many around plans replace affordable care act speculate potential areas change context set care older persons address
gut microbiota recently emerged important regulator brain physiology behaviour animals ingestion certain bacteria probiotics therefore appear potential treatment major depressive disorder mdd however conceptual aspects need elucidation therefore aimed investigating whether habitual diet interact effect probiotics depression related behaviour examined potentially involved mechanisms underlying mediated behavioural effects forty male sprague dawley rats fed control con high fat diet ten weeks treated either multi species probiotic formulation vehicle last five weeks independently diet probiotic treatment markedly reduced depressive like behaviour forced swim test furthermore probiotic treatment skewed cytokine production stimulated blood mononuclear cells towards ifn gamma expense tnf alpha addition probiotics lowered hippocampal transcript levels factors involved hpa axis regulation whereas increased levels non targeted plasma metabolomics analysis revealed probiotics raised level acid potential neuroprotective agent findings clearly support probiotics potential treatment strategy mdd importantly efficacy attenuated intake western pattern diet associated mdd mechanistically hpa axis immune system microbial tryptophan metabolism important context importantly study clinical trials probiotics depressed patients elsevier ltd rights reserved
since establishment peoples republic china chinese government encountered several related transfusion transmitted diseases governments increasing attention blood safety prompted initiation series policies measures enhanced level safety blood supply met basic clinical demands blood billion people country blood donation screening strategies china predominantly comprise donor screening donor testing donor screening includes selection low risk blood donors use donor history questionnaire physical examination initial rapid donor testing donor testing includes direct pathogen detection tests year marked change blood donor selection screening policies china paid donation predominant mode blood donation donor screening donor testing conducted donation eligible allowed ensure safety blood donor testing performed donation implementation blood donation law promote voluntary donation donor testing eliminated reduce amount waiting time provide convenient donation experience blood donors however national requirement blood undergo rounds testing using different equipment reagents conducted different personnel donor selection paid donation donation voluntary donation fixed volunteer groups latter mode donation provides lowest risks currently screened hepatitis virus hiv hepatitis virus hbv units previously now routinely tested innovations testing technologies methods also brought changes screening parameters instance screening hbv pathogens evolved early use method later use independent enzyme linked immunosorbent assay now widespread application nucleic acid test since chinese government established capacity several blood centers government million nationwide expansion although chinese government worked enhance blood safety many challenges remain concern exists rising rates hiv infection existence hbv infection transmission emerging blood borne diseases continue challenge safety blood supply elsevier inc rights reserved
contribution propose dynamic gradient damage model phase field approach studying fracture phenomena quasi brittle materials impact type loading conditions several existing approaches account tension compression asymmetry fracture behavior materials reviewed better understanding models provided traction experiment give efficient numerical implementation model explicit dynamics context simulations results obtained parallel computing discussed computational physical point view different damage constitutive laws tension compression asymmetry formulations compared respect approximate brittle fracture copyright john wiley sons ltd
common non malignant age related disease men benign prostatic hyperplasia androgens genetic predisposition play important roles normal prostate growth progression however accumulating evidence indicates factors aging obesity also contribute etiology management includes medical treatment surgery currently drug therapy uses blockers inhibitors alpha reductase enzyme latest studies demonstrated fraction patients resistant therapy article reviews new risk factors etiology mechanisms resistance therapy
group innate lymphoid cells defined expression transcription factor related receptor gamma play key roles regulation inflammation immunity gastrointestinal tract associated lymphoid tissues consist largely two major subsets like also demonstrate significant plasticity heterogeneity recent advances begun dissect relationship subsets define distinct functional states within intestinal tissue microenvironment review discuss ever expanding roles context intestinal homeostasis infection inflammation focus comparing contrasting relative contributions subsets
environmental impact building industry significant construction industry constitutes major part worlds total energy consumption result building designers constantly pay attention energy economics buildings green building practices like passive solar building design advanced construction building operation practices evolved years passive solar architecture basically refers usage structural non structural elements building comfort conditions additional operational costs makes best possible use local geographic climatic conditions measures help decreasing operational costs building increasing thermal comfort occupants often leading enhanced productivity energy efficiency measures also improve building cost operation reduced temperature inside building one factors identity comfort level great extent hence necessary predict internal air temperatures building study attempt made developing mathematical models predict air temperature inside building works attempts development neural network regression tool predict temperature inside simple construction fed various building specifications input results artificial neural network found close agreement actual site recorded data first time ann used application purpose validation testing data recorded four rooms varying architectural aspects past year taken recordings taken hourly basis
social deficits core symptom autism spectrum disorder however perturbed neural mechanisms underpinning deficits remain unclear suggested social prediction errors coding discrepancies predicted actual outcome decisions play crucial role processing social information surface anterior cingulate cortex social prediction errors typically developing individuals crucial social signal altered individuals autism spectrum disorder importantly degree social prediction error signalling aberrant correlated diagnostic measures social deficits effective connectivity analyses revealed typically developing individuals autism spectrum disorder magnitude social prediction errors driven input prefrontal cortex data provide novel insight neural substrates underlying autism spectrum disorder social symptom severity research surface anterior cingulate cortex prefrontal cortex provide targeted therapies help ameliorate social deficits autism spectrum disorder
nursing homes lack information technology supporting clinical work spite potential improve safety quality efficiency nursing home care united states increased attention medical error concern patient safety prompted general recommendations develop sophisticated technologies support clinical decision making point care promote data standards electronic records develop systems communicate however little known applications best support communication risk assessment practices improve resident outcomes nursing homes thus overall aim study evaluate differences nursing homes impact communication use technology related skin care pressure ulcers used mixed method approach conduct case studies two nursing homes one high one low observational analysis social network analysis used identify patterns communication types locations also focus groups conducted explore communication strategies used certified nursing support pressure prevention practices overall results social network analysis observational data indicate direct interactions registered nurses licensed practical nurses frequent low home occurred centralized locations nursing station compared high home moreover findings supported focus group results indicate high home robust integrated communication strategies non allow interactions throughout facility require less frequent face face interactions verify orders report patient status results study provide insight design assessment different forms communication support clinical work relevance industry nurses bear great burdens nursing home care yet issues persist poor quality variable performance caregiving lack implementation proven care interventions one new hope improvement nursing home care introduction improve communication clinical decision making quality care elsevier rights reserved
meta analytic procedures used test effects violent video games aggressive behavior aggressive cognition aggressive affect physiological arousal empathy desensitization prosocial behavior unique features meta analytic review include restrictive methodological quality inclusion criteria past meta analyses cross cultural comparisons longitudinal studies outcomes except physiological arousal conservative statistical controls multiple moderator analyses sensitivity analyses social cognitive models cultural differences japan western countries used generate theory based predictions meta analyses yielded significant effects outcome variables pattern results different outcomes research designs experimental cross sectional longitudinal fit theoretical predictions evidence strongly suggests exposure violent video games causal risk factor increased aggressive behavior aggressive cognition aggressive affect decreased empathy prosocial behavior moderator analyses revealed significant research design effects weak evidence cultural differences susceptibility type measurement effects evidence sex differences susceptibility results various sensitivity analyses revealed effects robust little evidence selection publication bias
paper describe control electronics industrial test system based low cost developed system hydraulic pulse system generates series high pressure hydraulic pulses max based pneumatic hydraulic circuits describe requirements overall concept embedded control system user interface security features network connectivity description software solution describe implementation hierarchical ordered program threads program main control state machine conclusion describe calibration method system calibration curves present diagram photo functional prototype system
opportunistic parasites species suggested preferentially tumor tissue cancer patients demonstrate annotated gene genome encodes efficiently catalyzes also kinetic characteristics catalyzed analogue determined demonstrated expression enzyme infected cell cultures dramatically alters activity various anticancer antiviral including due close association human cancers presence markedly influence therapeutic efficiency based drugs
direct gaze salient nonverbal signal social interest intention communicate particular duration direct gaze modulate perception social meaning gaze cues however poor eye contact deficits social cognitive processing gaze specific diagnostic features autism therefore investigating gaze provide key insights neural mechanisms related autistic symptoms employing functional magnetic resonance imaging fmri parametric design investigated neural correlates influence gaze direction gaze duration person perception individuals high functioning autism matched control group purpose dynamically faces virtual characters displaying direct gaze different durations evaluated four point scale behavioral results revealed participants showed significant difference ratings depending gaze duration control group rated virtual characters increasingly increasing gaze duration neural level direct gaze increasing direct gaze duration recruit regions social neural network control participants indicating processing social salience perceived communicative intent participants however regions social neural network engaged decreasing amounts gaze neural response processing direct gaze suggestive social information processing authors published elsevier inc open access license
type interferon ifn system recently suggested play important essential roles pathogenesis however clarification type function triggering factor pathogenesis yet failed activation type ifn system host defense peptide carries numerous immunomodulatory properties implicated pathogenesis several autoimmune diseases including systemic lupus erythematosus sle expression regulated various endogenous factors including active form vitamin aim study explore potential role relation type ifn system patients compare sle patients healthy controls investigated muscle symptomatic non symptomatic skin biopsies patients short disease duration muscle biopsies patients long disease duration six sle patients symptomatic non symptomatic skin five muscle six skin biopsies healthy individuals served controls tissue specimens stained neutrophils dendritic cells resistance protein macrophages addition double staining also performed serum levels investigated patients short disease duration healthy controls found expression major type interferon inducible protein macrophages higher muscle tissue patients compared healthy controls expression mainly derived neutrophils neutrophils increased symptomatic non symptomatic skin sle patients increased symptomatic skin compared healthy controls moreover expression symptomatic non symptomatic skin sle patients higher compared patients healthy controls difference expression skin sle patients compared healthy controls patients short disease duration low levels compared healthy controls conclusion present study supports hypothesis activate type initiate inflammatory process prolonged exposure immune system type eventually break tolerance lead autoimmune elsevier ltd rights reserved
present work describes electrochemical reduction dye iii methanol mol applied potential promotes commercial sample reduction products analyzed high performance liquid chromatography optimized conditions aromatic carcinogenic harmful compounds bis formed bond cleavage electrochemical reduction compared chemical reduction using sodium findings illustrates commercial iii condition forms number products known active technique used mimic important redox reactions human metabolism environment highlighting possible formation products toxic original dyes
mechanisms moral violent video game play recently received considerable attention among communication scholars date however study analyzed prevalence moral factors violent video games fill research gap present approach includes systematic literature review content analysis moral cues embedded narratives actual game play top ranked first person findings suggest moral factors frequently embedded first person prevalence varies considerably violent video games include violence distorted consequences implications findings research violent games discussed
children autism spectrum disorders asd long known deficits performance gestures motor deficits also correlate social communicative deficits date precise nature errors involved clearly mapped based observations individuals asd performing gestures hypothesized simultaneous execution multiple movement elements especially impaired affected children examined school aged participants asd age matched controls performing seven simultaneous gestures required concurrent performance movement elements nine serial gestures elements performed indeed group gesture type interaction whereas groups greater difficulty performing simultaneous serial gestures children asd times greater performance simultaneous serial gestures controls results point potential deficit simultaneous processing multiple inputs outputs asd deficits relate models social interaction highlight parallel processing nature social communication autism international society autism research wiley periodicals inc autism res international society autism research wiley periodicals inc
increasing availability violent video games implication recent school raised volume public debate effects games aggressive behavior related variables article reports experiment designed test key hypotheses concerning short term impact exposure violent video games young women population received relatively little attention research literature results brief exposure violent video game increased aggressive behavior analyses suggested violent video game effect aggression mediated instrumental aggressive motivation partially mediated motivation results suggested violent video game effect aggression greater game player controls sex violent game character wiley liss inc
increased expression beta associated fibrotic syndromes alzheimers disease hence regulation activity suitable strategy treatment conditions beta type transmembrane protein released cell surface shedding protease expressed inactive requires proteolytic maturation serine proteases present study demonstrate first time differences activation soluble membrane bound beta suggest transmembrane serine protease new potent activator beta determined show pancreatic capable activating full length beta cell surface analysed specific peptide cleavage assay western blotting confocal laser scanning microscopy maturation full length beta required activity cell surface releasing transmembrane proteins previously shown amyloid precursor protein app
optimized design smart post beam actuator performed study smart material based stack actuator used prime drive beam actuator actuators high force small displacement devices possess high energy density high bandwidth study bench top experiments conducted investigate angular tip due new design linear motion amplification device developed circumvent small displacement stack actuators enhances actuator mechanical leverage factor four model based dynamic elastic stability analyzed using equation formal optimization carried using newly developed meta heuristic nature inspired algorithm named algorithm utilizes capability optimized conjunction generates end order degrees output end optimized design less weight induces large end useful development various mechanical aerospace devices edge micro nano aerial vehicles robotic systems
minimum energy control problem fractional positive electrical circuits bounded inputs formulated solved sufficient conditions existence solution problem established procedure solving problem proposed illustrated example fractional positive electrical circuit
dynamic loads high capacity power grids normal severe conditions concerns system operators maintain voltage stability reactive power often drawn loads various generated sources operational power factor compensating methods used depending load types reactive power patterns continuously monitor correctly counteract fast changes extremely rapid var compensation especially transient conditions using power electronics combining power control engineering facts equipped selected power electronic switching appropriate methods respond system variations almost time regulates system voltages based voltage source converters absorbing generating reactive power contrary based static var compensator output current inductive capacitive controlled independent system voltage paper presents design voltage controller analyze validate dynamic behavior facts device severe transient imbalance using powerful computer simulation application modeled phase network various parameters steady state condition short interval system fault regulator provided severe transient maintaining sufficient bandwidth perform necessary controller behavior simulated distribution system model subjected severe three phases ground fault rapidly varying three phase load
several studies investigating causes delay projects construction industry conducted worldwide study investigates causes delay construction projects oil gas processing facilities serves case study cooperation council countries using questionnaire data collected project managers employed different organizations oil gas industry survey results showed high degree agreement among perceptions project stakeholders clients contractors causes project delay evidence suggest causes project delay differ significantly according organization size organizational ownership moreover seven factors identified major causes project delay although six identified elements general factors account delay project industry one interaction engineering procurement found unique construction projects oil gas industry findings study value organizations planning conduct construction projects oil gas processing facilities nations similar environments countries
studies shown evening type subjects used stimulating substances presented psychiatric disorders morning type subject however lack data patients addiction aim study describe associated factors sample outpatients beginning treatment addiction subjects assessed questionnaire addiction severity index mini international neuropsychiatric interview subjects addiction comparing multivariate analysis showed significantly associated poly problematic addiction non substance cannabis addiction mood disorders severity addiction associated antisocial personality disorder results suggested associated specific addiction pattern psychiatric disorders elsevier ireland ltd rights reserved
objectives describe prevalence risk drinking participation health related behaviors practices associations risk drinking health related behaviors practices among older persons completing health risk appraisal elderly design cross sectional study using data self administered survey sample settings persons three organizations surveyed american association persons large medical group community based senior health center southern california participants persons age years older measurements included items health characteristics drinking behaviors including amount alcohol use two screening measures cage cut eye short screening test geriatric version participation selected health related behaviors practices social defined fewer weekly screened negative cage defined two responses hazardous fewer weekly screened negative harmful fewer weekly screened positive possible risk weekly screened positive least squares regression models used assess effects harmful possible risk drinking health related practices behaviors also conducted analyses using three definitions social possible risk hazardous harmful drinking results respondents social harmful hazardous possible risk hazardous harmful possible risk commonly reported driving drinking driven someone drinking respectively harmful possible risk likely social smoke less likely use regularly findings observed regardless drinking groups defined conclusion groups risk commonly engaged selected adverse health related behaviors practices social
biologics disease modifying drugs use germany treatment rheumatoid arthritis since usually failure least one conventional synthetic analyzed temporal changes factors influence decision either first analyzed data naive patients german biologics register rabbit switched new therapy three recruitment periods factors influencing therapeutic decision analyzed means machine learning methods logistic regression analysis recruitment periods number previous high dosages glucocorticoids day higher significantly associated decision first time chance receiving increased patients moderate disease activity moderate glucocorticoid dosages day comorbidities heart failure prior malignancy men higher chance receiving women first recruitment period private health insurance high education employment significantly associated frequent prescription recruitment periods time dependent changes impact disease activity concomitant drugs gender comorbidity prescription mirror increasing therapeutic options growing experience application new substances patients higher risk influence demographic social factors reflect safety concerns patients increased risk adverse events also need drug costs
hematopoietic cell transplantation rapidly evolving field active preclinical clinical development new strategies patient assessment graft selection manipulation pre post transplantation drug cell therapy new strategies require evaluation definitive clinical trials however trials face unique challenges including relatively small number performed single center diverse indications requiring approaches complex nature intervention risk multiple complications immediate post transplantation period risk important though infrequent late effects blood marrow transplant clinical trials network established national heart lung blood institute national cancer institute meet challenges years network proven successful infrastructure planning implementing completing trials providing definitive answers questions leading improvements understanding practice opened trials one half phase one half phase enrolled patients published papers addressing important issues treatment patients life threatening malignant blood disorders review describes networks key components success lessons learned past years challenges future american society blood marrow transplantation published elsevier inc
objectives estimate life expectancy years hiv positive people compare life expectancy recent estimates general population education methods patients aged years older enrolled swiss hiv cohort study eligible patients matched swiss residents sex year birth education life expectancy age estimated monotherapy dual therapy early combination viral therapy later recent parametric survival regression used model life expectancy results hiv positive patients residents included life expectancy age hiv positive individuals increased years confidence interval monotherapy era years recent era differences life expectancy across educational levels emerged recent period life expectancy age years years education compared years higher education estimates general population years respectively male sex smoking injection drug use low cell counts also independently associated mortality conclusion switzerland educational inequalities life expectancy larger among hiv infected persons general population highly educated hiv positive people estimated life expectancy similar swiss residents education earlier start effective smoking cessation programs improve hiv positive life expectancy reduce inequalities copyright wolters kluwer health inc rights reserved
background tropical tree long history traditional use parts africa southeast asia also known leaves long used people region manage pain opioid withdrawal fatigue actually consumed throughout world effects opioid substitute form tea smoked ingested case reports associated exposure psychosis seizures medical conditions deaths clinical manifestations effects defined clinical studies limited data research suggest dose dependent effects exist addition antidepressant activity like effects effects growing concern drugs effects safety use resulted national international attention primarily due increase hospital visits deaths several countries believed caused extracts plant dearth double blind controlled studies study aim use existing literature clarify benefits risks diagnosis evaluation misuse emerging trend western world methods literature review using databases embase medline pubmed cochrane library evaluated authors analyze current state benefits risks diagnosis evaluation results data analysis suggested possesses benefits effects wells effects seems inhibit pro inflammatory mediator release vascular permeability enhance immunity addition antidepressant however cause seizure arrhythmia impair memory function death psychological manifestations described feeling relaxed severe symptoms aggression hostility psychosis medical manifestations described dry mouth vomiting movements currently liquid chromatography mass spectrometry ion mobility spectrometry suggested promising rapidly screen products providing positive success rate conclusion data analysis determined biochemical benefits prove toxicity risks contrary seems potential side effects benefits severe real health hazards lead death clinical psychological medical manifestations use among multiple compounds leaf appear increasing western world promising methods accurately identify compounds still ongoing
tumor peptides specific representative breast cancer cell line mcf carefully selected displayed peptide library freely available web namely database tumor peptides selected synthesized evaluated terms affinity toward mcf cells tested best performing peptide sequences sequence separately conjugated spherical gold nanoparticles yielding stable examined ability actively target mcf cells comparison fibroblast cells gold exhibited good selectivity binding affinity flow cytometry low cytotoxicity assayed cell death experiments uptake targeted breast cancer cells confirmed transmission electron microscopy analysis work demonstrates possible exploit conjugation short peptides selected displayed libraries develop nanomaterials reliably tumor targeting potential irrespective specific knowledge target cell biology elsevier ltd rights reserved
contributes pathogenesis several chronic inflammatory diseases including bowel enhancing responses mediates strong subsets particularly mucosal cells however signaling pathways induces different subsets incompletely understood investigated function human cells together tgf enhanced secretion ifn human memory cells induced expression transcription factors bet correlated secretion ifn contrast alone induced high levels memory cells committed cells however enhance expression cells expression transcription factor hydrocarbon receptor regulates expression affected transcriptome analysis cells revealed increased expression response blocking receptor antibodies abrogated induced secretion furthermore increased production peripheral cells isolated patients crohns disease data suggest differentially induces expression effector cytokines provides potential target therapeutic intervention driven chronic inflammatory diseases
rationale idiopathic pulmonary fibrosis ipf progressive fatal interstitial lung disease ild characterized abnormal extracellular matrix ecm remodeling hypothesized ecm remodeling result plasma profile proteins specific ipf distinguish patients ipf idiopathic objectives identify biomarkers assist distinguishing ipf non ipf ild methods developed panel ecm ecm related lung specific analytes measured plasma patients ipf derivation cohort patients ipf validation cohort comparison groups included patients rheumatoid arthritis associated ild ild patients alternative idiopathic ild healthy control subjects multivariable logistic regression models identified biomarkers differentiated patients ipf ild continuous diagnostic threshold versions biomarkers considered thresholds chosen maximize diagnostic sensitivity specificity univariate receiver operating characteristic curve analysis diagnostic score created promising analytes measurements main results plasma surfactant protein matrix metalloproteinase mmp significantly distinguished patients ipf patients ild individually combined index odds ratio ipf least one index exceeded threshold confidence interval least two analytes elevated odds ratio ipf increased confidence interval conclusions biomarker index mmp enhanced diagnostic accuracy patients ipf compared non ipf ild data suggest biomarker index improve diagnostic confidence ipf
nanotechnology application concrete presents innovative approach improve concrete properties based ability manipulate material atomic scale paper presents review nano materials used concrete literature survey revealed four nano materials often used modify concrete properties include nano silica nano nano titanium dioxide nano carbon nano tubes carbon nano fibres four nano materials shown improvement many concrete properties nano nano reduce bleeding segregation improve mechanical transport properties tend adversely affect fresh properties due overcome surfactant ultrasonic used however significantly improve mechanical properties concrete paper also discusses concrete durability improved nano materials added concrete addition paper identifies several research needs based gaps current state knowledge using nano materials concrete
parkinsons disease circuit level disorder clinically determined motor subtypes despite evidence suggesting subtype different pathophysiology neuroimaging studies examined induced differences neural activation dominant postural instability gait difficulty subtype patients motor task goal functional mri fmri study examine task induced activation connectivity striatal cortical motor circuit healthy controls patients patients administration fourteen cognitively intact patients age sex matched healthy controls completed right hand fmri paradigm collectively patients medication showed motor cortex relative healthy controls even controlling performance intake patients significantly increased activation left putamen compared patients healthy controls interaction analysis revealed increased effective connectivity posterior putamen areas motor circuit patients patients novel induced difference neural responses motor subtypes significant implications elucidating mechanisms underlying distinct phenotypic manifestations enabling classification motor subtypes objectively using fmri
recently single nucleotide polymorphism snp gene related large artery atherosclerotic stroke caucasian populations genome wide association study gwas study aimed determine whether gene polymorphisms associated stroke chinese han population case control study designed patients stroke healthy controls enrolled ten snps located gene genotyped associations genotypes stroke analyzed logistic regression model adjustment potential confounders although associated stroke genotype adjusted two novel snps genotype adjusted genotype adjusted associated stroke haplotype analysis indicated haplotype adjusted block haplotype block associated stroke dimensionality reduction analysis single locus model indicated important predicting risk stroke significant snp snp interactions among tested snps detected results indicated genetic variants gene influence risk stroke chinese han population
photosynthetic eukaryotes complex evolutionary history shaped multiple events required tight coordination organelles rest cell plant glutamate receptors form large superfamily proteins predicted proven non selective cation channel activity regulated broad range amino acids involved different physiological processes sensing resistance fungal infection root pollen tube growth response pathogens present knowledge limited located plasma membranes however recent studies localized different isoforms mitochondria suggesting possibility play specific role processes work performed comparative analysis sequences bacteria various photosynthetic eukaryotes particular novel types selectivity filters bacteria reported adding new examples great diversity superfamily highest variability sequences found among sequences brown green algae land plants closely related green algae analyzed work family underwent great expansion vascular plants among plant iii includes sequences considered ancient likely emerged later silico analysis allowed identification sequences putative target organelles sequences predicted localization mitochondria randomly distributed among different type suggesting compartment related specific function maintained across species elsevier rights reserved
case study known method often applied teaching learning mainly graduate level depth implementation method allows using common case study courses semester academic year common case study consistently used since master science planning management civil engineering goal develop generic competencies content coordination cohesion step implementation portfolio order improve assessment course competences course provides initial statement explaining additional information required expected outputs additional coordination needed order succeed therefore coordination plan define common set contents every course work individualized way every course designed common criteria finally guide indicate steps students follow order solve problem giving clues circumstances guides want show solution problem layout filled student throughout learning process paper also describes contents guides example
balancing selection describes form natural selection results persistence multiple variants trait intermediate frequencies within populations offering multiple occurring functional variants interactions systems balancing selection reveal evolutionary mechanisms emergence persistence adaptive variation natural populations focus mechanisms several functional variants given trait arise process typically requiring multiple mutations highlight balancing selection favour specific features genetic architecture review evolutionary molecular mechanisms shaping architecture first balancing selection affects number loci underlying differentiated traits respective effects control one loci persistence differentiated functional variants limiting recombination impact sometimes lead evolution chromosomal rearrangements particularly preventing adaptive combinations increasingly noted features systems similarly due frequency maintained balancing selection dominance key property adaptive variants high limited recombination also influence associated genetic load linked recessive deleterious mutations capture deleterious elements locus balancing selection reinforce polymorphism promoting finally according recent scans balanced polymorphism pervasive generally thought stress need functional ecological studies characterize evolutionary mechanisms operating systems
cms cytoplasmic male based hybrid breeding effective pollen fertility restoration essential prerequisite achieving maximum grain yield one hand minimizing genes cms inducing cytoplasm derived collected iran used achieving goal genes four sources iran iii analysed producing three way cross hybrids elite cms single cross without given gene materials evaluated large plots index grain yield plant height traits six environments experiment gene used seven pairs marker selected carrier non carrier lines served experiment line pairs three sources lines grouped high low respectively using highly diagnostic cms hybrids carrying gene suffered significant grain yield reduction experiments respectively thousand kernel weight reduced whereas quality traits slightly affected traits significant genetic variance existed among presence absence given gene offers chance reduce ultimately overcome presently observed performance reductions brought genes
functional protein homeostasis essential maintenance normal cellular physiology cell growth cell survival proteasome inhibition cancer cells protein homeostasis way synthetic proteasome inhibitors like selectively cells solid cancer cells appear respond less part due rescue mechanism protein response endoplasmic reticulum stress mechanism leads temporary protein biosynthesis translational level show proteasome inhibition also interfere general protein biosynthesis already stage biogenesis analysis revealed induces changes cytoplasmic morphology also pronounced morphological changes associated accumulation transcription factor sites stress induced intra accumulation observed cancer cells dose time dependent manner studies revealed preferentially localized inside dense granular component furthermore affected number also volume distribution components localization granular component together association rna transcripts cells undergoing cell stress suggest new function cell stress management elsevier gmbh rights reserved
objective clarify distinct main duct neoplasms using microarray analysis background represent pancreatic cell field defect causes multiple occurrences lesions display features monoclonal progression methods total rna extracted fresh frozen tissue samples pancreas tissue pancreas two individuals whole human genome microarray analysis performed fixed paraffin embedded tissue specimens distinct collected patients genomic dna extracted mutational status investigated immunohistochemical analysis performed validate expression pattern indicated proteins results microarray analysis revealed individual displayed pair wise correlation coefficients contrast histological grade different individuals displayed coefficients plot analysis revealed individual displayed closer linear relationship furthermore heat map hierarchical cluster analyses revealed individual classified branch gene expression patterns similar mutational distinct consistent immunohistochemical assessment five specific proteins demonstrated expression pattern two lesions observed samples conclusions findings using molecular analyses indicate display features monoclonal progression
paper presents systematic solution kinematics planar mechanism aspect groups planar mechanism decomposed groups detailed calculating order groups unknown solve problem first decomposed groups classified three types according foundation establishment automatic solving algorithm decomposed groups second data structure group presented enables automatic solving algorithm input output parameters group decomposed groups stored component stack parameters stored parameter automatic algorithm detect identification group component stack corresponding parameters parameter order decide group one solved proposed systematic solution able generate automatic solving order groups planar mechanism allows adding modifying removing groups time two planar mechanisms given examples show detailed process proposed systematic solution
study developed examined feasibility model based system identification approach cardiovascular disease diagnosis basic premise approach possible diagnose cardiovascular disease disease induced alterations arterial mechanical properties manifested proximal distal arterial blood pressure waveforms first lumped parameter model wave propagation reflection artery using measurement proximal distal arterial blood pressure waveforms employs diagnosis logic form disease specific patterns model parameters referred alpha beta pulse transit time longitudinal change parameters used diagnose presence peripheral artery disease arterial illustrated feasibility proposed approach testing full scale silico arterial tree simulation results showed approach exhibited superior sensitivity ankle index convenience carotid femoral pulse wave velocity model parameters responded changes peripheral artery disease arterial whereas change ankle index parameters responded changes arterial pulse transit time changed together development convenient techniques measurement arterial blood pressure waveforms proposed approach evolve viable alternative state art techniques cardiovascular disease diagnosis
depressed parents increased risk psychiatric disorders although bipolar disorder major depressive disorder mdd found families clear whether transmission offspring mdd tends occur parents mood disorder subtype primary hypothesis offspring parents increased risk comorbid disorders common anxiety substance use relative offspring parents mdd offspring parents versus mdd also hypothesized greater risk externalizing disorders conduct disorder attention deficit hyperactivity disorder antisocial personality disorder mood disorders offspring studied adult offspring administered structured clinical interview dsm axis disorders establish presence psychopathology offspring aged years assessed using school aged schedule affective disorders schizophrenia present lifetime version parents children age ten completed child behavioral checklist data examined using cox proportional hazard regression difference hazard mood disorders offspring parents compared offspring parents mdd however number parent offspring characteristics increased risk mood anxiety externalizing substance use disorders offspring including self reported childhood abuse parent offspring offspring impulsive aggression age onset parental mood disorder disorders highly familial finding appears independent whether parents condition bipolar suggesting considerable overlap heritability mdd although parental characteristics limited influence risk offspring psychopathology reported childhood adversity parent child negative outcomes risk factors extend previous findings consistent stress
image definition influenced alignment errors optical system consisting hyperbolic parabolic major factors alignment errors gravity wind loads heat exchange optical systems like ground based vibration temperature gradient systems like space larger sensitive error sources becomes concerns researchers alignment errors corrected time keep systems working best condition order solve problem many methods proposed based detection wave front errors using wave front sensors like however wave front sensors used cause optical systems complicated example multi fields tested working one hand wave front sensor used moved around imaging plane hand wave front sensors used system complicated new method discussed alignment error correction evaluating quality spot diagrams based using stochastic parallel gradient descent algorithm method considers performance metric like spot diagram radius function control parameters uses optimization algorithm improve performance metric control parameters include positions iteration process used right way control position parameters considered problem come positions spot diagrams influenced iteration furthermore spot diagrams probably detectors spot diagrams correct better way put forward combination center tilt way ensures position error produced center tilt compensated formula provided paper give relationship based analysis optical system designed verify conclusion algorithm achieved computer programming position mirror controlled firstly problem verified spot diagram detector normal iteration process new way implemented iteration process spot diagram always center detectors order prove feasibility method three different alignment errors tested give disk finally experiment provide reference engineering practice
food restriction induces several physiological changes including weight loss metabolic adaptations mineral hormonal changes however effects cells elucidated therefore present study designed investigate effects secretion involved mechanisms ovariectomized rats rats divided fed control groups rats exhibited decreased body weight water intake urine flow sodium excretion increased plasma comparison control rats elevated basal angiotensin stimulated secretion cells hydroxy cholesterol cells group greater control group group higher protein expression acute regulatory star protein cells however different protein expression cytochrome side chain cleavage enzyme cells control groups summary increased activities synthase protein expression star protein cells involved effects rats also suggest increase associated anti group results helpful understanding role physiological adaptation renal sodium conservation
glioma rare brain tumour poor prognosis search modifiable factors intense reviewed literature concerning risk factors glioma obtained case control designed epidemiological studies order discuss influence methodology observed results reviewing association three exposures medical radiation exogenous hormone use allergy critically evidence case control cohort studies medical radiation hormone replacement therapy questionnaire based case control studies appeared show inverse association whereas nested case control cohort studies showed association allergies inverse association observed irrespective study design recommend questionnaire based case control design placed lower hierarchy studies establishing cause effect diseases glioma suggest state art case control study minimum accompanied extensive validation exposure assessment methods study sample regard exposures interest otherwise studies regarded hypothesis testing hypothesis generating consider holds true questionnaire based case control studies cancer chronic diseases although perhaps extent exposure outcome combination
encodes neutral key molecule skeletal development alveolar bone however effects periodontal ligament cells still unclear study authors analyzed effects human cells authors found increases mrna expression calcification related genes alkaline phosphatase type collagen related transcription factor cells contrast inhibitor clearly decreased mrna expression type collagen osteocalcin cells suggesting enhances next authors used exome sequencing evaluate genetic variants japanese population aggressive periodontitis among unrelated subjects authors identified single nucleotide polymorphism snp putative genetic variant among japanese people moreover harboring snp increase activity mrna expression type collagen suggesting snp inhibits effect cells data suggest plays crucial role maintaining homeostasis tissue
hybridization divergent species analyzed elucidate expression patterns distinct parental characteristics provide information extent reproductive isolation species known hybrid cross two highly divergent phenotypes provided opportunity examine occurrence parental characteristics hybrids shifts expression characters hybrids aged although phenotypes adult known many species effect hybridization phenotype inheritance understood effects hybridization yet investigated current study investigates phenomena resulting hybridization male type southern pacific female type highly toxic sds page enzymology western blot reversed phase hplc hplc used characterize male female two hybrid offspring aged general hybrid appeared exhibit overlapping parental profiles several different enzyme activity patterns hybrids expressed father specific mother specific toxin activity displayed apparent sex influenced expression patterns hybrid serine protease activities intermediate parental activities hybrid males profile provided strongest evidence type type characteristics expressed simultaneously hybrid contained distinctive characteristics parental species however possibility sex influenced development activity seen shifts hybrid female influence levels expression type type characteristics hybrid ultimately analysis known hybrid system reveals distinct characteristics used determining successful hybridization follow type type trend composition namely presence activity toxin published elsevier ltd
introduction biological disease modifying anti rheumatic drugs often administered combination methotrexate target specific inflammatory mediators transformed treatment rheumatic diseases especially rheumatoid arthritis also however high cost drugs many countries patient access many reached near patent numerous drugs development already approved generally lower reference products bio prices come patient access drugs increase making safety drugs area major interest areas covered article reviews publicly available safety data expert opinion available data relate tumor necrosis factor inhibitors rituximab anti monoclonal antibody use around world increases evidence supporting clinical safety compared also grows date new safety concerns raised studies rituximab treatment safety profiles consistent however careful post marketing remains necessary
context psychosocial factors impact lung transplant outcomes however currently unknown whether abuse influences lung transplant survival objective characterize abuse history adult lung transplant patients determine whether history associated mortality patients participants adult lung transplant recipients evaluated main outcome measures main outcome post lung transplantation survival secondary outcomes included demographic transplantation psychological assessment differences history abuse without results thirty three lung transplant recipients male median age years included history abuse common associated decreased survival following lung transplantation difference sex marital status smoking history abuse survivors victim abuse abuse survivors higher personality assessment total score measure maladaptive personality traits conclusion abuse common lung transplant patients associated increased mortality increased maladaptive personality traits preliminary evidence suggests lung transplant patients screened abuse history provided appropriate treatment issues potentially improve health outcomes transplantation
due cytochrome metabolism clinical trials treated chronic lymphocytic leukemia patients concurrent medications metabolized evaluated concomitant medication use treated patients outside context clinical trials seventy five patients medications increase toxicity drugs decrease efficacy nineteen patients concomitant inhibitors moderate strong two patients inhibitors although starting dose changed patients interacting medications difference month progression free survival rate discontinuation observed patients routine clinical practice patients concomitant medication potential influence metabolism formal medication review pharmacist considered patients initiating
mitochondria important regulators cell death cell survival mitochondrial levels critically involved processes one hand excessive mitochondrial leads induced mitochondrial outer membrane thus apoptosis hand mitochondria need order efficiently fuel acid cycle maintain adequate mitochondrial obtaining mitochondria largely dependent close contact sites endoplasmic reticulum called mitochondria associated membranes receptors responsible release comes release subsequent uptake mitochondria regulated cancer cells often modulate transfer mitochondria order promote cell survival inhibit cell death important regulators signals onset cancer cell lymphoma bcl family proteins increasing number reports highlight ability bcl protein family members regulate transfer mitochondria healthy cells cancer review focus recent insights dynamic regulation mitochondrial fluxes bcl family members impacts cell survival cell death mitochondrial energy production
four novel polymers poly poly bis phenyl phenyl oxide poly phenyl oxide poly bis phenyl phenyl oxide synthesized thermal properties device applications investigated correlate chemical structures performance bipolar host materials organic light emitting diodes show high thermal stability revealed high glass transition temperatures thermal decomposition temperatures weight loss polymers wide band gaps relatively high energy levels result spin coating method used prepare green organic light emitting diodes polymers typical host materials green device polymer host material shows performance maximum current efficiency center dot maximum external quantum efficiency maximum center dot reduced efficiency roll center dot much better devices polymers
dynamic model wind flow wind farms developed paper model based spatial discretization linearized navier stokes equation combined vortex cylinder theory spatial discretization model performed using finite difference method provides state space form dynamic wind farm model model provides approximation behavior flow wind farm obtains wind speed vicinity wind turbine afterwards model validated using measurement data energy research center netherlands wind turbine test site netherlands employing outcomes two wind flow models end goal work present wind farm flow model ordinary differential equations applied wind farm control algorithms along load power optimizations copyright john wiley sons ltd
international organizations ranging large small born global firms increasingly recognizing employees help operate across countries across cultures however individuals identify one culture diverse group organizations seeking leverage potential benefit deeper understanding resources possess challenges face conducted three studies total participants test relationships identity patterns personal social task outcomes consistent results across studies indicated individuals cultural identities higher identity social capital higher levels skills fewer cultural identities individuals integrated cultural identities higher identity integration experienced higher levels personal separated based results advocate two directions future research employees moving beyond cognitive mechanisms alone examining individuals simultaneously along spectrum identity
background multiple sclerosis inflammatory neurodegenerative disorder central nervous system cns reliable biomarkers urgently needed diagnosis management clues pathogenesis ebv implicated objective measure igg antibodies ebv nuclear antigen innate inflammation status paired serum cerebrospinal fluid csf samples untreated relapsing remitting patients materials methods anti igg titers beta tnf alpha cytokine levels measured untreated patients healthy controls results found higher serum anti igg levels patients healthy controls interestingly levels relative total protein much higher csf whereas anti antibodies significantly higher sera detailed analysis showed anti antibodies relative total igg also higher serum majority patients compared csf levels anti igg showed strong correlation serum csf conclusion findings newly diagnosed patients imply anti antibody production mainly periphery innate immune responses preferentially cns potential disease biomarkers implications pathogenesis warrant investigation published elsevier
time rupture thick high density polyethylene aged typical landfill composite liner configuration investigated pressure kpa degrees geosynthetic clay liner needle nonwoven geotextile protection layer separating drainage gravel containing seventeen diameter tests conducted addition months required antioxidants stage tests indicated lag period stage months time start degradation rupture stage iii months giving total inferred time rupture months years brittle per sample million cracks per oriented machine direction located directly gravel contact side gravel gravel gravel least frequent largest calculated strains perpendicular rupture direction rupture occurred although average stress crack resistance samples still approximately minimum results indicate importance minimizing tensile strains design liner system american society civil engineers
aim study investigate efficacy pre early delayed pulsed electromagnetic field treatment cartilage trabecular bone knee osteoarthritis rats induced low dose seventy five week old male sprague dawley rats assigned five groups pre early delayed control osteoarthritis induced rats right knee joint control rats received single sterile saline injection right knee male rats received pre day end week early end week end week delayed end week end week treatment weeks rats sacrificed time point right harvested micro computed tomography histology biomarker analyses performed found pre treatment preserved trabecular bone prevented bone loss induced rat model early delayed treatment maintained treatment increased bone cartilage formation decreased bone cartilage resorption pre early treatment moderate effects cartilage degradation time point treatment initiation crucial treating become potential biophysical treatment modality osteoarthritis wiley periodicals inc
surface concrete one surface concrete appearance detection evaluation surface always difficult problem paper established method detect surface concrete image analysis put forward evaluation parameters surface distance affect area detection accuracy image method partition used ensure detection accuracy according size concrete member based image processing toolbox matlab image gray contrast enhancement image threshold segmentation technology used extract characteristics concrete surface threshold value shape characteristic coefficient distinguish cracks surface chosen relationship scale area ratio established parameters area ratio maximum diameter comprehensively evaluate surface quality concrete elsevier ltd rights reserved
objective systematic review presents loading protocols applied using implants treatments materials methods clinical trials assessed use implants studies involving treatment patients surgery simultaneous treatments appliances mini plates considered electronic databases medline medline process non indexed citations pubmed embase web science evidence based medicine reviews searched help senior health sciences abstracts appeared fulfill selection criteria selected consensus original articles retrieved evaluated methodological checklist references also hand searched possible missing articles results eleven articles fulfilled selection criteria established five studies involved use implants six involved use purposes individual methodological analysis article made conclusions loading protocols implants involve minimum waiting period months applying forces loading protocols involve immediate loading waiting period weeks apply forces success rates implants average higher
camera video processing channels readout large focal plane requires compact readout chain correlated double sampling technique generally used signal readout also adopted application implemented called dual slope integrator method designed implemented asic analog signal processing asic goal amplify signal close output order maximize signal noise ratio send differential outputs others requirements chip process output half channels operate specific back end board designed especially lab test purposes clock signals analog outputs stores data memory contains bits memory interface fpga signals components board generates timing sequence written languages registers permit define various tests parameters labview allows load update registers check proper operation several series tests including linearity noise crosstalk performed past year characterize room cold temperature present back end board detectors integrated perform characterization whole readout chain
objective international task force recommended disease remission minimal disease activity mda target treatment psoriatic arthritis psa remission mda attained within months initiating medication aim study establish proportion patients psa achieve mda months methotrexate treatment methods patients initiated naive biologics included primary outcome achievement mda months defined presence least following joint count joint count psoriasis area severity index body surface area points health assessment questionnaire score patient global disease activity visual analog scale vas score patient pain vas patients identified treated least months sufficient data analysis months results months patients achieved mda patients achieved achieved patient global disease activity criterion lower back pain associated lower probability achieving mda conclusion use achieves mda months patients compares data tumor necrosis factor inhibitor use
tobacco beta gene gene gene introduced tomato micro tom via agrobacterium mediated method transformants obtained confirmed gus staining pcr southern blotting northern blotting analysis probes revealed variation expression among transformants transcription level one three copies transgene respectively integrated tomato nuclear genome performance test resistance generation transgenic tomato lines showed transgenic lines exhibited higher resistance infected pathogens plants resistance levels related expression levels transgene showing dose effect transgenic tomato harboring cassette showed highest disease resistance suggested genes effects resistance independent lines high disease resistance low variability stable expression selected studies molecular breeding
sexual transmission hiv aids increasing iran main route infection among women order foster development future hiv prevention interventions women researchers need understand factors influence sexual risk reduction behaviors group aim study explore predictors condom use among women risk hiv develop model condom use sample women risk hiv cross examined predictors condom use among women risk hiv women recruited drop centers voluntary counseling testing centers condom use among women risk hiv examined using path analysis fit indices showed good fit model condom use self efficacy social support less gender roles influenced sexually protective behaviors women risk hiv results provide basis future gender specific intervention programs among women risk hiv researchers practitioners organizations play central role protecting health population make use results benefit sexual reproductive health programs
paper proposes bidirectional three level llc resonant converter new pulse width amplitude modulation control method different control signals three different operation modes different voltage gains therefore achieve wide voltage gain range switching among three modes attractive energy storage system applications needing wide voltage variation proposed topology operates constant switching frequency easy implement digital control achieve soft switching switches diodes circuit conventional llc resonant converter performance proposed converter validated experimental results prototype maximum output current
background disease pathogenesis comprised complex inflammatory immune response oral bacterial dysbiosis like inflammatory diseases sexual evident periodontal diseases periodontitis inflammatory chemokines direct neutrophils migrate site infection pathogen interestingly chemokines also involved regulating pathogen induced osteoclast formation previous reports show differences bone turnover lymphocyte recruitment sexes hypothesize chemokine expression differentially regulated sex thus results differential osteoclast formation material female mice utilized isolate neutrophils based expression specific defined osteoclast progenitors cells stimulated lipopolysaccharide lps analyzed neutrophil infiltration gene expression defined osteoclast progenitors primed macrophage colony stimulating factor receptor activator ligand stimulated lps osteoclasts via trap mrna isolated gene expression analysis via quantitative polymerase chain reaction response lps male neutrophils vitro respond increased chemokine expression significantly osteoclast formed response lps compared females support observations humans regarding sexual oral bacterial infections alveolar bone loss males strong inflammatory response bacterial infection resulting increased inflammatory microenvironment reduced pathogenic bacteria clearance increased osteoclast driven bone loss response differential expression key chemokines
increased interest analytical category social sciences provide construction management economics scholar new possibilities better exploit detailed empirical data collected construction industry related fields theories tended dominate social sciences since least mid social sciences sought release methodological hard sciences now recognized subject within different social science article advocates broad engagement within construction management research presents series analytical concepts empirical studies stress built environment human beings far passive stable common sense thinking easily believe image recognizes dynamic fluid nature thus arguably conducive stimulating construction management scholarship
dimensional equations arising propagation laser beam plasma studied paper analytic soliton solutions obtained means symbolic computation based find vertical bar vertical bar inversely related omega positively related inversely related cope positively related envelope high frequency electric field plasma density omega omega plasma electronic frequency frequency laser beam mean density plasma mass ion ion sound velocity plasma respectively head interaction found transformed one omega increasing decreasing also period bound state interaction decreases omega decreasing considering driving forces laser induced plasma explore associated chaotic motions effects omega omega omega omega wave number laser beam omega cope represent frequencies driving forces respectively found chaotic motions weakened omega omega increasing omega decreasing periodic motion occur cope reaches critical value chaotic motions independent omega elsevier ltd rights reserved
although rat hepatitis virus hev identified wild rats cell culture systems virus established recent report suggesting presence antibodies rat hev human sera encouraged rat hev human cells liver obtained wild rats inoculated onto human cells rat hev replicated efficiently cells irrespective genetic group rat hev particles released cultured cells lipid associated membranes surface depleted treatment protease density sucrose shifting northern blotting analysis revealed genomic rna rna infected cells rna possessed extreme end sequence downstream highly conserved sequence establishment culture systems rat hev allow extended studies mechanisms viral replication functional roles hev proteins investigation required clarify potential rat hev elsevier rights reserved
paper presents new adaptive mesh refinement strategy offers alternative classic methods automatic local refinement needs additional storage good cpu time results makes fine candidate specific studies applied fluid structure interaction problem prediction behavior submerged net applications companies scientific questioning indeed structure code modeling net already uses lot memory space introduce scheme require data structure original algorithm employs local cells identify neighbor every cell auto adaptive mesh applied fluid model test case describing hydrodynamic behavior panel published elsevier ltd
paper deals stability chaotic behavior related structural properties relatively broad class finite dimensional strictly causal systems class nonlinear systems consideration described state space representation form system properties investigated new approach based new abstract state energy concept proper generalization known theorem form energy conservation principle resulting energy function induced output signal power determines structure proper system representation corresponding system state space topology state parameter requirements plays crucial role proposed method several examples solved results simulation shown illustration fundamental ideas basic attributes proposed method
paper presents control variable speed wind turbine operating partial load order eliminate direct measurement wind speed proposal estimated aerodynamic torque used determine optimal reference speed control maximum energy conversion maximization efficiency energy conversion minimization detrimental dynamical loads control trade offs considered design optimal discrete time feedback controller wind energy conversion system based optimization quadratic cost function performance proposed control submitted step variation wind speed evaluated computational simulations also presented proposals control electrical generator elsevier ltd rights reserved
cloud computing internet based computing virtual shared servers provide software infrastructure platform resources customer pay use basis cloud computing increasingly becoming popular many enterprise applications data moving cloud platforms however enormous use cloud probability occurring intrusion also increases major need bringing security transparency reliability cloud model client satisfaction one security issues reduce impact type intrusion environment address issue security solution proposed paper provide collaborative framework hybrid intrusion detection system ids based mobile agents virtual therefore hybrid intrusion detection system consists three types ids namely ids ids ids three layer cloud computing first layer use ids framework collect analyze detect malicious data using mobile agents case attack collect level second layer malicious data detected first layer generation new signatures using ids based signature generation algorithm network intrusion detection system finally ids placed third layer new signatures used update database belonging ids database belonging ids cluster neighboring also ids hardware unable control communication virtual machines moreover blind virtual traffic mostly deployed virtual machine monitor level cloud providers control equally mobile agents play important role collaboration used framework investigation hosts transfer data malicious transfer update database neighboring ids cloud technique neighboring ids use new signatures protect area control type attack type close loop control collaborative network security management framework identify address new distributed attacks quickly effectively
objective patients constipation account million physician visits year care costs patients irritable bowel syndrome constipation ibs chronic idiopathic constipation compared general public received little study study aim describe healthcare utilization compare medical costs patients ibs matched controls community based sample methods nested case control sample ibs cases matched controls case group selected county individuals responding community based survey gastrointestinal symptoms received healthcare participating epidemiology project provider using healthcare utilization data unadjusted adjusted standardized costs compared year periods prior survey ibs patients controls patients controls two time periods chosen conditions episodic long term results outpatient costs ibs patients year period prior survey significantly higher controls respectively adjusting morbidities age sex ibs outpatient costs emergency room costs significantly higher controls respectively year period prior unadjusted data analyses cases compared controls demonstrated significantly higher imaging costs ibs cases procedure costs cases year period limitations data collected random community sample primarily receiving care limited number providers area conclusions patients ibs significantly higher outpatient costs year period compared controls ibs patients also higher costs general population
context lysine cml results oxidative stress linked cardiovascular objective study investigate association sleep disordered breathing source oxidative stress methods participants cardiovascular health study women significantly higher cml concentration compared without association significant among associated cml concentration among elderly women men cardiovascular health accumulation cml adverse health consequence
ambient intelligence ami active topic research gaining attention characteristics transparency intelligence older people one take advantage use ami systems thanks characteristics ami systems focus older adults real needs satisfy one main motivations adapt technological innovations perceived benefits perhaps related healthcare home care perceived valuable beneficial paper presented multi agent architecture mas healthcare ami system treat older people motor impairment problems using specific devices control patients movements way natural relationship ami mas widely exploited ami proposes development context aware systems integrate different devices recognize context act accordingly agents provide effective way develop systems since agents reactive proactive exhibit intelligent autonomous behavior one main differences system provides therapist support design new therapies adapt specific person control execution instead using fixed set exercises
understanding pathogenic variation plant pathogen populations key development use host resistance managing diseases highly virulent previously shown occur one clonal lineage lineage contrast clear association yet shown race clonal lineages race carries effector gene hosts carry resistance gene hypothesis tested race arose single clonal lineage expected acquired horizontal gene transfer plants hypothesized previously diverse sample isolates nine clonal lineages race isolates present lineage conversely lineage isolates displayed race phenotype moreover nucleotide sequences identical among lineage isolates identical sequences race isolates genbank finding race single clonal lineage identical sequences consistent hypothesis race arose molecular markers virulence assays also confirmed established finding found lineage pathogenicity assays indicated cotton olive isolates lineage highly virulent cotton olive low virulence tomato
modeling spatial correlation ground motion caused coherent contributions source path site provide valuable loss hazard information realistic ground motion intensities geological survey software package utilizes deterministic empirical approach estimate median ground conjunction observed seismic data estimates used loss estimation algorithms estimate economic losses significant seismic events around globe incorporating spatial correlation ground motion shown improve seismic loss estimates particular park applications statistics probability civil engineering investigated computing spatially correlated random fields however large scale grids computational requirements method work memory efficient algorithm developed compute random fields implemented using framework new iterative parallel algorithm based decay properties associated ground motion correlation function shown significantly reduce computational requirements associated adding spatial variability ground motion estimates demonstrate quantify impact adding peak ground motion spatial variability resulting earthquake loss estimates
background allergic diseases thought inherited prevalence allergic diseases however increased dramatically last decades suggesting environmental causes development allergic diseases objective studied risk factors associated development atopic dermatitis allergic rhinitis asthma children non atopic parents country methods birth cohort newborns parents enrolled validated allergic diseases questionnaire physician verified total specific immunoglobulin ige levels children respectively completed year year follow clinical examination questionnaire blood samples total specific ige children collected follow visit results prevalence respectively children non atopic parents prevalence significantly higher children parents atopic combination section breastfeeding month showed highest risk infants living homes air filters highest risk male infants non atopic parents living homes without air filters highest risk conclusions breastfeeding affect development gender use air filters affect suggesting control perinatal environment necessary prevention atopic diseases children parents
background restriction influences aging processes extends average maximal life spans comprehensive assessment long term effects reducing intake energy phase study first randomized clinical trial examine metabolic psychological effects humans objective conducted follow study adults underwent control consumption determined whether weight loss acquired behaviors persisted study ended participants determined lifestyle behaviors design prospective longitudinal study assessed differences weight body composition psychological function energy expenditure body mass index men women control completed study biomedical results participants follow study subjects control completed visits follow months intervention mean sem weight loss observed group weight later despite weight percentage body fat fat mass remained significantly reduced baseline throughout follow remained significantly less control group follow group retained higher degrees dietary restraint avoidance certain foods conclusion intensive intervention similar induced weight loss maintained later probably result lasting effects acquired behaviors dietary restraint
crop production district state india characterized low input low yield concept rain fed agriculture field study conducted western region district develop suitable rainwater harvesting system test efficacy improving use efficiency harvested water multiple uses cost benefit analysis water harvesting system also carried find farmers water harvesting system developed integrating three components improving productivity component crops cropping units developing multiple water use systems iii use harvested water along surface groundwater resources based estimated annual costs returns benefit cost ratio found financial viability criteria also found favourable investment water harvesting tank integrated micro irrigation system fish farming study suggested rainwater harvesting implemented viable alternative conventional water supply farm irrigation projects considering fact land anywhere used harvest rainwater water use efficiency improved effective harvesting subsequent multiple uses stored water
present study lead free used electronics packaging industry reinforced different volume percentages nano size tin oxide respectively synthesize two new sets nanocomposites composites developed using microwave assisted powder route followed effects addition physical microstructural mechanical properties nanocomposites investigated mechanical properties composite systems increase presence best tensile strength realized composite reinforced vol vol tin oxide far exceeds strength morphology pores observed one factors affecting strength materials
assessing effect new electrical engineering course sequence follow courses one assessments survey distributed electrical circuits courses roughly one half year spent programming matlab problem solving using programming tools observation students consider programming important reasonably good confidence self efficacy solve problems using matlab however asked frequency use tools students report using week month significant number students report almost usage results consistent across junior years slight frequency use students view matlab tools problem solving yet another item acquire studies plan change instruction courses problem solving requires programming introduced existing survey used measure future improvement
recent years increased concerns pollution greenhouse gas emissions initiated wave policy change governmental industry non governmental organisations order reduce overall environmental impact ensure sustainable future green building council instance identified construction one emission intensive industries accounting around greenhouse gas production study hybrid life cycle assessment lca technique used analyse supply chain commonly used product construction industry one leading contractor building materials study demonstrates emission across lifecycle products identified analysed using different intervention options supply chain attempt reduce greenhouse gas emissions supply chain implementation cross docking principles use renewable sources energy determined major interventions elsevier rights reserved
due rapid development renewable energy waste energy recovery absorption energy storage important technology promising future however researches focus working fluid flow rather energy flow used electric power systems hard analyze entire systems whole contribution introduces electrical circuit analogy analyze absorption energy storage systems perspective energy flow turns energy storage release processes corresponding electrical circuits described kirchhoffs laws philosophy instead complex component analysis basis optimization absorption energy storage system converted conditional problem applying multiplier method offers optimization equations directly obtain optimal structural operating parameters best performance contribution optimized results offer higher power storage release cases respectively compared existing experimental results besides inspired batteries connected parallel series design multi stage absorption energy storage system store low grade heat provide high grade heat reveals superior newly proposed approach elsevier ltd rights reserved
background despite concerns rising treatment psychiatric patients psychotropic medications declining treatment psychotherapy actual treatment profiles psychiatric patients largely describe patterns treatment patients large psychiatric university hospital descriptive mapping treatment outpatients psychiatric department university hospital denmark information collected healthcare staff using item survey form value calculated chi squared test considered significant study preceded pilot study month period total consecutive patients assessed included age range years mean men women one hundred eighty eight patients used psychotropic medication monotherapy combination non pharmacological therapy ninety seven psychotherapy social support among inpatients physical therapy therapy total non pharmacological therapy fifty two patients monotherapy mean number treatment modalities used per patient patients department including non pharmacological modalities applied widely across settings patient categories however psychotropic medication clearly frequently applied treatment
inconclusive results reported studies investigating association brain derived neurotrophic factor bdnf polymorphism migraine present study conducted systematic review meta analysis published data order quantitatively estimate relationship migraine susceptibility comprehensive search performed pubmed web knowledge cochrane databases october pooled odds ratio corresponding confidence interval calculated estimate strength association additive dominant recessive model inheritance total five studies including cases controls identified meta analysis pooled data showed increased risk migraine allelic dominant model statistical significance lost one single study excluded analysis dominant allelic suggesting lack robustness pooled estimates stratified migraine type similar trend association detected statistically significant association reached subtype dominant model present meta analysis supports bdnf act genetic susceptibility factor migraine nevertheless large scale studies required confirm findings assess potential relationship migraine
two studies examine need cognitive closure referring individuals tendency reduce uncertainty via rigid processing style relates way attentional resources distributed previous studies show related focused rather distributed attention high individuals thus process tasks rather parallel order maintain performance additional task need shift attentional focus task often low individuals hand able process tasks parallel maintain performance additional task fewer attentional shifts test hypotheses asked participants perform main additional task simultaneously task performance participants eyes tracked line predictions interest area analysis showed related longer time additional task also associated runs task studies effects stronger difficult compared easy condition study paper first one directly test attention allocation depending levels elsevier ltd rights reserved
negative assay used efficiently study aging neurodegeneration drosophila make suitable large scale study method called rapid iterative negative ring assay established simultaneously multiple groups manually test tubes automated assay using controlled electric motor drive program analyze height using automated ring assay found ability strain wild type males particular declined rapidly day slowly day also found expression mutant beta accelerated age dependent decline ability moreover using examined effect third chromosome deficiencies accelerated locomotor decline beta expressing isolated
polymer soft material unit covalently surface scaffolds induce functional structural modification substrates properties surface coating approach attracted special fields stem cell biology tissue engineering regenerative medicine due facile fabrication usability various polymers extracellular matrix ecm like structural features vivo stability summarized polymer based grafting approaches comparing self assembled monolayer sam based coating method addition physico chemical characterization techniques surfaces stiffness elasticity roughness chemical composition affect cell adhesion differentiation proliferation also reviewed recent advancements cell biological applications polymer focusing stem cell differentiation supports implants tissue formation understanding cell behaviors polymer scale nanometer length contribute systematic understandings cellular responses interface polymers scaffolds simultaneous effects cell behaviors promising platform designs
solar thermal fuels harvest store solar energy closed cycle system conformational change molecules release energy form heat demand aim developing tunable optimized solid state applications designed three derivatives functionalized aromatic groups phenyl butyl phenyl groups contrast makes films derivatives formed uniform amorphous films charged discharged light heat many cycles thermal stability films critical metric thermally greatly increased degrees able achieve record high energy density solid state improvement compared previous solid state reports furthermore solid state improved charged charged previous solid state reports results point toward molecular engineering effective method increase energy storage improve improve thermal stability thin film
impact depression quality life qol social support neither characterized clinical samples women depression relative contributions depression menopausal symptoms hot declining qol clarified study compared qol measures social support functional disability non depressed women evaluated women aged years presented menstrual cycle elevated plasma fsh levels met criteria structured clinical interview administered determine presence absence major minor depression outcome measures included quality life enjoyment scale questionnaire disability scale global assessment functioning social adjustment scale social support index tests used compare outcome measures ninety women control women participated study women reported significantly decreased qol social support adjustment increased disability compared non depressed women neither reproductive status alone presence hot significant negative impact qol measures accompanied significant reductions qol social support disability similar depression women stages life also contribute decreased qol community clinic based samples women remains unclear whether clinical characteristics identified reflect pre existing risk factors depression effects current depression future clinical treatment studies women distinguish depressed women outcome measures include qol
porous media combustion relatively new concept due inherent characteristics high efficiency low emissions found wide applications many practical systems like internal combustion engine engine water petroleum gas etc study concept employed pressure usefulness media consisting silicon sic terms efficiency emissions investigated conditions optimum efficiency emission brought systematic analysis different geometry exergy calculation major highlight study highest efficiency porous media found similar higher average thermal efficiencies available indian market elsevier ltd rights reserved
iron loss modeling crucial electric machine design however current models feature severe drawbacks complex thus hardly applied require high effort measuring computation accurate paper technique introduced calculating instantaneous power loss ferromagnetic materials without taking magnetization history account standard measurement setup specimen shape used considered approach comprises required measurements nonlinear loss modeling extensive verification different flux density waveforms frequencies addition detailed qualitative comparison known iron loss models given presented technique gives accurate results obtaining model easy moreover calculation instantaneous losses based previous magnetization state material modeling error particular instant time impact subsequently calculated characteristics future model ensure accurate iron loss calculation electric machine designs
objective despite concerns exposure violent media data youth exposure violent movies study examined exposure among young adolescents methods used random digit survey adolescents aged years using previously validated methods determined percentage number adolescents seen recently released movies report results rated violence motion picture association america british board film classification coded extreme violence trained content results violent movies seen median estimated million adolescents aged years popular violent movie movie seen million children million years age watching extremely violent movies associated male older less educated parents poorly school black male adolescents particularly high risk seeing movies example blade training day movie seen respectively sample overall versus black male adolescents violent movie exposure also associated measures media parenting high exposure adolescents significantly likely television report parents allowed rated movies conclusions study documents widespread exposure young adolescents movies extreme graphic violence movies rated violence raises important questions effectiveness current movie rating system
background syndrome characterized obstruction blood flow hepatic veins aim study analyze diagnosis etiology management methods analyzed patients females males mean age age treated found patients frequent symptom median total follow months non covered bare covered inserted patients diagnosis myeloproliferative neoplasm mpn based criteria inherited acquired assessed therapy regard etiology results etiology identified cases mpn found common risk factor especially polycythemia vera mutation detected mpn cases second common factor inherited non covered bare group primary rates year years shunt creation covered group year year primary rates respectively average year intervention rate per patient procedures bare group covered group interventions frequent mpn patients patients heparin beginning switched vitamin antagonist top anticoagulant vigorous therapy underlying disorder necessary conclusion serious life threatening disorder major cause morbidity mortality therapy requires multidisciplinary approach insertion dedicated covered effective treatment cases resistant conservative approach lower dysfunction rate number interventions
air pollution become major social problem motor applied traction system traction motor operates wide operation range paper concentrated winding presented existing model high speed harmonics motor becomes large becomes problem control side therefore designing vehicle electric motor necessary design motor order reduce load back force harmonics high speed winding method tendency permanent magnet study improvement satisfy constraints harmonics high speed back force existing model need improve design satisfy output characteristic get design parameters tendency analysis design final model using design parameters finally verify final models characteristics using fem
preferable detect leakage status earliest phase manufacturing process assembly hydraulic components leakage faults avoided integrating based microcontroller pressure transducer also environmental safety considerations study developed hydraulic leakage detection system using air lower pressure operation ranges measuring pressure decay signals captured real time pressure decay data collected developed hydraulic leakage detection system hydraulic testing tube installed tight tight connections simulate leakage leakage treatments two different system pressure levels statistical analysis found developed prototype system capture visualize pressure decay curve real time two signals pressure drop test start end point pressure drop rate testing period used featured characteristics quickly detect hydraulic leakage components status
pathways mechanisms regulate pulmonary surfactant synthesis processing secretion catabolism extensively characterised using classical biochemical analytical approaches constructed model largely experimental animals surfactant phospholipid metabolism alveolar epithelial cell whereby phospholipid endoplasmic reticulum selectively transported body storage vesicles subsequently processed secretion surfactant phospholipid complex mixture individual molecular species defined combination fatty acid groups comprehensive description surfactant phospholipid metabolism requires consideration interactions molecular species however recently lipid analytical techniques kept pace considerable advances understanding enzymology molecular biology surfactant metabolism mass spectrometry now provide sensitive platforms rapid characterisation surfactant phospholipid composition molecular detail combination administration phospholipid substrates labelled stable extends analytical approach quantification synthesis turnover individual molecular species surfactant phospholipid methodology involve ideally suited application clinical studies review provide overview metabolic processes regulate molecular specificity surfactant together examples application stable isotope technologies vivo first time begun explore regulation molecular specificity surfactant synthesis human subjects elsevier gmbh rights reserved
computer aided design cad model data among heterogeneous cad systems indispensable collaborative product development currently industry mainly uses standardized neutral files based methods implement exchange time application web ontology language file underlying semantic web technologies cad model data exchange gaining importance popularity within academia coexistence different types methods generated series controversies questions within industry academia yet neutral files based exchange methods completely implement model data exchange among heterogeneous cad systems challenges addressed date developed cad model data exchange standards introduced cad model data exchange cad model data exchange really need issues existing neutral files based exchange methods file based exchange methods need addressed future studies paper proposes conduct study standardized neutral files based exchange methods file based exchange methods depth analysis widely used standard exchange product model data step method newly emerging methods first provided paper makes detailed comparison two types methods based analysis finally issues two types methods need addressed future discussed
density flame controlled based foam prepared method first solution containing synthesized added second solution containing derivatives water catalysts possible reactions preparation discussed obtained fourier transform infrared spectra indicate increased amount rings generated increasing molar ratio groups size walls cells became smaller thinner less carbon dioxide air first solution preparation process shown scanning electron microscopy images thermogravimetric analysis curves demonstrated weight loss temperature greater degrees residual weight retention degrees addition differential curves demonstrated thermal stability decreased limiting oxygen index increased gradually increasing molar ratio groups meanwhile density obtained ranged molar ratio groups ranged prepared based exhibit great flame lower density wiley periodicals inc
article develops answers question psychiatric processes general psychological predisposition makes people susceptible media violence consumption way lead lifelong aggressive behavior authors discuss assumptions make question trying answer review factors known destructive aggressiveness clarify environmental exposures small part long list discuss brain interacts structurally functionally altered environment introduce resilience enables respond functionally trauma others less work examining exposure violence within schools impact school climates vulnerable children illustrating importance social factors relating aggression authors conclude question allowing human psychopathological reactions seen complexity
conformal maps planar domains important tool geometry processing used shape deformation image riemann mapping theorem guarantees exists conformal map two simply connected planar domains yet computing map efficiently remains challenging practice one main algorithmic questions correspondence boundaries domains one hand exist number conformal maps two domains thus many potential boundary yet given full boundary prescription conformal map exist furthermore approximate boundary fitting enough many applications therefore propose alternating minimization algorithm finding boundary conformal map given initial global alignment two input domains utilize green complex coordinates space conformal maps source domain thus compute continuous map without requiring discretization domain without mapping intermediate domains yields efficient method allows modify additional user provided constraints point point stroke stroke furthermore show easily generalize setup quasi conformal maps thus space mappings reducing area distortion compare algorithm state art methods mapping planar domains demonstrate achieve less distorted maps inputs finally show applications approach stroke based deformation constrained texture mapping
major substitute high molecular weight adversely affect reproductive function like broad exposure population expected postulated secondary oxidized metabolites human metabolites possible biomarkers exposure developed line hplc method determination human urine identification performed authentic standard substances quantification via isotope dilution analytical method highly selective sensitive limits quantification pilot study volunteers general german population oxidized metabolites found samples abundant mean maximum followed three oxidized metabolites correlated strongly among rho detected one sample regarded weak marker exposure analytical method able perform human metabolism studies provide metabolic conversion factors investigate extent exposure general population elsevier rights reserved
background intravenous infusion min pituitary activating polypeptide induces migraine like attacks migraine patients without aura conducted pilot study investigated lower doses exert similar migraine inducing abilities methods randomly allocated six patients receive intravenous infusion min minutes double blind three way cross study headache migraine characteristics recorded hospital hours post hospital hours phases results induced migraine like attacks one six patients two six patients three six patients patients reported head pain min whereas five six participants reported head pain min found difference three doses auc headache intensity hour observation period exploratory analysis showed significant difference conclusion trend dose response relationship dose incidence migraine observed suggest min optimal dose induce migraine like attacks
background smokers mental illness health care providers often concerned smoking cessation mental health smokers mental illness tend nicotine dependent experience severe symptoms nicotine withdrawal difficult distinguish psychiatric symptoms addition smoking cessation increase blood levels hence side effects psychotropic medications improved monitoring nicotine withdrawal medication side effects help distinguish temporary withdrawal symptoms psychiatric symptoms facilitate targeted treatment help smokers mental illness manage acute phase nicotine withdrawal objective aim research examine acceptability feasibility implementing structured assessments nicotine withdrawal common medication side effects people mental illness quitting smoking using telephone smoking cessation service methods monitoring involves administering pre cessation contact post cessation nicotine withdrawal scale assessing eight symptoms anger anxiety depression difficulty increased appetite insomnia adverse side effects checklist symptoms example dry mouth increased following day update training mental health asked offer assessments mental illness addition usual counseling group interviews conducted months later examine implementation barriers benefits results barriers included integrating new structured practice counseling difficulty limiting content new items initial respond changes symptoms benefits included ability provide objective feedback changes symptoms identified early benefits quitting provided clients provided opportunity early intervention symptoms worsened conclusions structured monitoring withdrawal symptoms medication side effects able integrated counseling valued clients given evidence benefits limited pilot study recommend considered larger scale adoption
chronic migraine debilitating disorder significant impact patients society nearly frequently reported light sensitivity headache attack pituitary activating polypeptide plays important role activation trigeminal system migraine pain identify effect chronic treatment endogenous associated symptoms migraine experimental chronic migraine model induced intermittent intraperitoneal injection anxiety like behaviors determined modified elevated plus maze days light dark box days blood levels cortisol assessed enzyme linked immunosorbent elisa kits chronic injection evoked anxiety like behaviors treatment effectively attenuated anxiety like behaviors paradigms found increased blood levels cortisol significantly reduced treatment additionally staining hematoxylin eosin revealed reduced induced increase number satellite glial cells trigeminal ganglion furthermore first time showed repeated increased white blood cell counts mean platelet volume decreased platelet counts results indicated decreased migraine associated symptoms possibly attenuating endogenous cortisol levels therefore hold therapeutic managing chronic migraine
although business application data stored relational databases programming languages wire formats integration middleware systems table centric due costly format data faster computation trend push integration operations closer storage representation address alternative case defining declarative table centric integration semantics within standard integration systems replace current operator implementations known enterprise integration patterns equivalent memory table processing show practical realization conventional integration system non reliable data intensive messaging example results runtime analysis show table centric processing promising already standard single record message routing transformations potentially message throughput multi record table messages
one main challenges water management determine current water use condition availability future generations hence sustainability study proposes use water footprint indicator assess environmental sustainability water resources management river basin level current study presents methodology developed applies case study relatively new indicator measures total volume freshwater used production factor application ever growing evaluation water use production processes calculation involves water resources blue precipitation stored soil green pollution grey provides comprehensive assessment environmental sustainability water use river basin methodology based upon simulation water cycle conducted combining hydrological model decision support system methodology allows assessment environmental sustainability water management different levels analysis decisions made water planning process affect sustainability sustainability study carried river basin south eastern spain among complex basins europe given special competition use pollution alternative sources among others results indicate blue water use sustainable due generalised also reveal surface water pollution sustainable mainly caused phosphate concentrations assessment future scenarios reveals problems additional measures implemented therefore water management environmentally short medium term elsevier rights reserved
purpose paper seeks examine whether violence embedded stories ads contribute effectiveness along lines researched elements physically attractive model specifically paper aims assess whether violent content story adds perceptions overall evaluations attitude toward attitude toward product design methodology approach paper uses experimental approach comprising two studies participants randomly allocated ads different levels violence story findings main finding representations real violence opposed violence produced higher levels attitude toward story attitude toward attitude toward product compared violence effects however moderated level story product highest response levels obtained ads violent story content dealing explicitly product originality value finding violent stories ads positive charge assumption violence narrative device created story also observation many consumers appear stories violent content yet main finding challenges existing research violent ads violence consists image visually exposed brand questions dominant approach media violence research emphasizes negative effects media violence
gait analysis using wearable wireless sensors economical convenient effective way provide diagnostic clinical information various health related issues work custom designed low cost wireless gait analysis sensor contains basic inertial measurement unit used collect gait data four patients diagnosed balance disorders additionally three normal subjects performing dynamic gait index tests wearing custom wireless gait analysis sensor small includes tri axial accelerometer integrated circuit two ics texas instruments microcontroller subject position tests raw gait data transmitted near real time gait data collection analysis order perform successful classification patients normal subjects used several different classification algorithms back propagation artificial neural network ann support vector machine svm nearest neighbors binary decision trees based features extracted raw gait data accelerometers range used input feature overall classification accuracy obtained ann svm using similar high classification accuracy results also achieved standard deviation values used input features classifiers results show gait data collected low cost wearable wireless gait sensor effectively differentiate patients balance disorders normal subjects real time using various classifiers success eventually lead accurate objective diagnosis abnormal human underlying etiologies future patient data collected
simple theoretical framework gender role attitudes emerge women participate labor market advanced western nations relatively gender working environments consequently gender attitudes east asian counterparts women east asian societies hand said support conditions resulting female labor force participation traditional attitudes toward gender roles taiwan however women economically active two east asian societies japan south korea even though women three societies favor traditional gender division labor thus taiwan women experiencing inconsistencies active working lives traditional values study inconsistency coexistence old new reflected mind set women using comparative data east asian social survey analyzed gap responses questions gender attitudes relation working conditions general gender role attitudes found significant differences size gaps taiwanese women expressed views questions concerned practical economic interests retained basic traditional attitudes towards gender roles homes gap larger taiwan japan south korea
paper reports source follower based active filter topology front ends wideband systems proposed active filter noise figure bandwidth improved adopting proposed sub omega source follower conventional operational amplifier based unity gain buffer simply changing location filter applying proposed scheme conventional key filter also improves rejection performance furthermore proposed filter topology ultimately suppresses offset voltage noise unity gain buffer active circuit filter proposed filter implemented cmos measurements exhibit input noise figure mhz bit tunable frequency range proposed filter consumes supply chip occupies
music draws body space time relationships offer experience makes personal social emotional spiritual connections people cultural identity formed arts music medium people explore identities study examines music facilitates holistic development two born chinese australian evolving self model hierarchy human needs music education aims offer scaffolds illuminate self discovery phenomenological analysis used report multiple semi structured interviews undertaken three years study considered interaction various value systems fusion psychological cultures process development identity formation research gap existing approaches understanding social contexts influencing acquisition skills occupational choices permissive parenting participants experienced account able follow career music without familial resistance current findings advocate music education spiritual aspects experiences perceived mirror fostering holistic development participants
paper prove possible use techniques specific electromagnetic field synthesis study electrical circuits definition network presented system matrix network circular matrix allows analytical evaluation eigenvalues singular values resonance frequencies calculated exactly demonstrated passive active networks
paper compares activation false memory traces true memory traces control items learning version deese roediger mcdermott paradigm drm used conjunction decision task one hundred participants read drm lists non word lists delay manipulated experimental conditions immediate minute minute asked classify actually studied items cis new words non words results showed independent delay classification latency cis actually studied words active matched control items moreover results showed delay affects activation true false memories rate overall results seem support hypothesis false memories trace becomes additive traces integrated episodic memory features true memories
paper presents analysis implications recent studies performed characterize products modern recovery facilities important worker protection assumptions solubility related molecular species produced materials humans critical properly assess radiation dose intakes understand implications establish protective exposure standards airborne concentrations limits intake etc recent studies information historical professional literature reviewed address issue solubility related characteristics data important design programs assessment chemical radiological aspects worker exposure products modern recovery plants conventional situ recovery plants data suggest strongly oxide form produced facilities therefore product solubility related precipitation chemistry thermal exposure temperature given peroxide precipitation low temperature drying methods used many modern recovery facilities today soluble products produced impacts products pulmonary system except perhaps case extreme acute small residual pulmonary retention beyond month two likely small measure traditional sampling current state art natural vivo lung counting techniques recovery plants revisit adequacy current programs context process product workers potentially exposed soluble concentrates urine specimens submitted analysis approximately weekly basis including analysis biomarkers associated potential renal injury glucose lactate dehydrogenase ldh protein additionally implications compliance current nuclear regulatory commission regulations discussed applicable agreement state agencies need recognize importance versus dose relationship interest worker protection
study corrosion behaviors carbon steel stainless steel investigated water saturated system examine condition injection wells enhanced oil recovery operations model potential effects resulting injection activities including effect heat transfer stream surrounding rock formation compression frictional losses accounted model applied offshore wells using realistic data offshore depth considered vary power function lateral distance sea floor depending scales injection calculations show corrosion rates wall order carbon steel stainless steel rate obtained results study provide insights material selection injection wells design injection operations leakage monitoring risk assessment elsevier ltd rights reserved
objective association psoriatic arthritis psa disease activity lipid profiles explored studied association active peripheral arthritis enthesitis lipid measurements psa methods conducted cross sectional study psa patients enrolled consortium rheumatology researchers north american registry low activity defined clinical disease activity index presence enthesitis results patients psa enrolled registry june october complete data lipid measurements patients enthesitis moderate high group included women current smokers patients moderate high disease activity shorter duration disease likely less likely use tumor necrosis factor tnf inhibitors moderate high peripheral disease activity associated abnormal total cholesterol odds ratio abnormal triglycerides adjusting gender duration psa smoking body mass index diabetes modified assessment questionnaire scores following medications methotrexate non biologic disease modifying anti rheumatic drugs tnf inhibitors cholesterol lowering medications fish oil presence enthesitis irrespective scores associated abnormal conclusion findings suggest association peripheral joint inflammation lipid dysregulation psa studies needed determine treating psa improves lipid profiles cardiovascular mortality elsevier inc rights reserved
fully functional tree representation supports large number operations constant time using bits however full idea hard implement simplified version operation time implemented shown practical competitive describe new variant original idea much simpler implement worst case time operations implementation based version experimentally shown superior existing implementations elsevier rights reserved
two experiments examined effects forward associative strength fas backward associative strength false items themes constructed four associates strongly related item terms fas four associates weakly related item terms fas fas manipulated controlled across strong weak associates fas controlled across strong weak associates manipulated strong associates presented one weak associates presented second test items disproportionately attributed source used present lures strong associates compared lures weak associates manipulated fas manipulated outcome demonstrates fas influence item false global matching models explanation false explanation offered spreading activation theories
session initiation protocol application layer protocol used signaling purposes manage voice connections text based protocol vulnerable range denial service attacks attacks render servers proxy servers memory cpu time paper consider two types attacks namely flooding attacks coordinated attacks detection flooding attacks affect servers coordinated attacks affect servers model operation discrete event system des design new state transition machine name probabilistic counting deterministic timed automata describe behavior operations also identify different types anomalies occur des model appear form illegal transitions timing constraints appear number otherwise seen subsequently map various attacks type anomaly des learn probabilities various transitions delay set training sequences trained detect anomalies hence various attacks perform thorough experiment computer simulated traffic report detection performance various attacks generated custom scripts
trial comprising fifty genotypes conducted three locations india year estimation grain concentrations analyze interactions employing additive main effect multiplication interaction model study revealed significant effects genotype environment genotype environment interaction grain concentration model genotypes score nearly zero mean greater mean considered adaptable studied environments grain concentration genotypes globe mutant grain concentration genotypes found stable diversity analysis using genomic est markers indicated studied genotypes diverse est revealed lower polymorphism compare genomic two major clusters identified similarity indigenous genotypes grouped cluster grouped cluster indicating role geographic origin diversity based multi location evaluation grain concentrations molecular characterization proposed development grain rich varieties development mapping populations study genetics mapping gene
context data care represents public health strategy using hiv surveillance data link persons living diagnosed hiv infection hiv related medical care objective investigate feasibility approach applied partner services program serving geographically diffuse area new york state design disease intervention specialists received training function expanded partner services advocates hiv surveillance data identified presumed care advocates attempted locate individuals hiv related care pilot september august setting four new york counties home one third new york participants total presumed main outcome measures linked hiv medical care cases verified attending hiv medical subsequent case assignment hiv care hiv laboratory test months following case closure retention hiv care hiv laboratory tests months following case closure results majority assigned cases located located cases confirmed cases successfully care success differ gender transmission risk major race ethnicity categories however direct relationship age successful ninety five percent cases medical care retained care individuals advocates likely care individuals interviewed care advocates individuals intervention conclusion effective conducted outside large metropolitan areas closed health care systems also effectively incorporated existing partner services programs however relative priority work established context
small emerging companies possibly flooding construction industry strain construction economy stay support sustain participants important organisation deals individuals organisations understand correct ethical codes conduct business environment minimise behaviour industry new contractors need understand apply principles ethical conduct business environments research aimed investigating whether ethical conduct among new entry level emerging contractors contribute ensure sustainable competitiveness south african construction industry research also aimed determining whether education knowledge business project construction management addition building contracts contribute new entry level emerging contractors ethical conduct sustainable competitiveness literature reviewed results quantitative research among professional south africa formed basis study ethics sensitive topic within construction industry therefore difficult gather data directly contractors participate fear revealing identities negatively influence personal business unbiased respondents directly linked emerging contractors give objective opinions questioned included architects quantity engineers project managers construction construction managers study revealed ethics important factor business environment correct application thereof partially contribute sustainable competitiveness new entry level emerging contractors turn promote long term survival business furthermore knowledge good management practices building contracts contribute successfully run business however average new entry level emerging contractor insufficient experience knowledge management construction projects building contracts study valuable construction industry professionals contractors clients provides research information problem area industry
one result rapid growth functions jobs offshore locations usa progressed point already affects everyday lives cars drive large portion work components computers typically manufactured offshore back usa electronic diagnostics calls answered phenomenon implications lives jobs engineers scientists assume now future something highly developed even lesser developed countries face consequently growth major impact educational objectives engineering programs resultant engineering curricula worldwide paper presents recent data product job offshore discusses various dimensions phenomenon addition potential loss engineering high end technical jobs cultural aspects intellectual property issues strategic planning concerns macro economic issues presented example effects societal fabric countries recipients manufacturing service center china india significant rapid controversial also begun change way engineering programs countries educate students addition intellectual property issues create major risk companies considering certain less developed countries issues broadly categorized robustness strength intellectual property laws degree laws implemented factors fluctuations geo political conditions substantially impact decisions phenomenon now affecting engineering careers play major role shaping engineering education worldwide next generation engineers need possess ability work seamlessly across cultures outstanding communication skills familiar principles project management systems integration educational models begin address requirements presented elsevier ltd rights reserved
objective use novel geographic methods large scale claims data identify local distribution pediatric chronic diseases new york city methods using emergency claims database identified proportion unique children aged diagnosis codes specific medical psychiatric conditions proof concept compared prevalence estimates traditional health surveys registry data using geographically granular data available addition used home addresses map local variation pediatric disease burden results identified new york city children visited emergency department least though sample included publicly insured children found moderate strong correlations prevalence estimates compared health surveys registry data geographic levels strongest correlations found asthma mental health conditions county among younger children respectively moderate correlations neighborhood identified obesity cancer among adolescents correlations health districts strong obesity depression estimates nonsignificant strong negative correlation suicide attempts using also identified local hot spots pediatric chronic disease conclusions conditions easily identified claims data emergency department surveillance help estimate pediatric chronic disease prevalence higher geographic resolution studies needed investigate limitations methods assess reliability local disease estimates
mechanisms underlying efficacy antidepressant smoking cessation aid far fully characterized present study first examine effects visuospatial task related parietal eeg alpha power asymmetry asymmetry previously found associated severity depressive symptoms depressive symptoms greater alpha power right left parietal area participants smokers none clinically depressed randomly assigned placebo group group double blind study eeg performance visuospatial task collected days placebo sustained release relative placebo group group especially subgroup positive right versus left parietal alpha power asymmetry pretreatment reduction parietal alpha asymmetry driven largely decrease right parietal alpha power findings support hypothesis induce changes parietal eeg asymmetry shown previous literature associated reduction depressive states traits
persistent debate define episodic memory whether uniquely human capacity one hand many animal cognition studies employ content based criteria criterion argue animals possess episodic memory hand many human cognition studies emphasize subjective experience retrieval essential property episodic memory human enables propose perspectives examine distinct complementary aspects episodic memory drawing conceptual distinction episodic memory traces mental time travel episodic memory traces sequential representations particular experienced episodes mental time travel draws traces requires components construct scenarios larger narratives various animals store episodic memory traces yet possible humans able construct reflect narratives lives flexibly compare alternative scenarios remote future elsevier ltd rights reserved
quantum key distribution promises secure communications however low bit rate meet requirements high speed applications despite many solutions proposed recent years neither efficient generate secret keys compatible systems paper based chaotic cryptography middleware technology proposes efficient universal protocol directly deployed top existing system without modifying underlying protocol optical platform initially takes bit string generated system input periodically updates chaotic system efficiently outputs bit sequences theoretical analysis simulation results demonstrate protocol efficiently increase bit rate system generate bit sequences perfect statistical properties compared existing methods protocol efficient universal rapidly deployed system increase bit rate system becomes bottleneck communication system
paper reports design development evaluation framework implements virtual humans information provision framework used create interactive multimedia information visualizations images text audio videos models provides dynamic data modeling mechanism storage retrieval implements communication multimodal interaction techniques interaction involve human agent agent environment agent agent communication framework supports alternative roles virtual agents act existing systems standalone applications even integral parts emerging smart environments finally evaluation study conducted participation people study developed system terms usability effectiveness employed assisting mechanism another application evaluation results highly positive promising confirming systems usability encouraging research area
increase environmental health literacy leadership skills latino youth worked members youth community council outreach arm longitudinal study impacts environmental chemicals childrens health program provided hands research experiences related endocrine disrupting chemicals cosmetics possible health effects use participatory research principles taxonomy educational objectives describe development leadership youth researchers using data multiple qualitative sources explore youths engagement wide range research action processes promising outcomes including perceptions improved youth self esteem leadership career orientation discussed challenges time constraints high priority youth concerns addressed study implications youth engaged participatory science leadership programs presented
background family caregivers people dementia significant unmet needs regard caregiving role despite utilize services reduce burden aim study examine barriers facilitators service use among family caregivers people dementia method semi structured interviews conducted family caregivers community dwelling people dementia partner caregivers men women offspring caregivers men women interviews transcribed analyzed using thematic analysis results six main barriers three facilitators identified barriers facilitators relevant across many types services supports barriers inability find information relevant services support poor quality services services caregivers beliefs caregiving role resistance care recipient key facilitators good communication care recipient expert point contact beliefs caregiving role enabled use services conclusion given significant changes aged care service system important discuss barriers faced family caregivers people dementia inform development targeted strategies address lack service use among family caregivers
new state space approach proposed model time dependence extreme value process generalized extreme value distribution extended incorporate time dependence using state space representation state variables either follow autoregressive process moving average process innovations arising distribution using bayesian approach efficient algorithm proposed implement markov chain monte carlo method exploit accurate approximation distribution ten component mixture normal distributions methodology illustrated using extreme returns daily stock data model fitted monthly series minimum returns empirical results support strong evidence time dependence among observed minimum returns elsevier rights reserved
social economic burden allergic rhinitis increasing significant effects quality life patients suffering therefore physicians require evidence based guidelines regarding diagnosis differential diagnosis proper management management patients korean academy asthma allergy clinical immunology developed new clinical guidelines appropriate management especially korean patients core questions questions practitioners several experts field pediatrics developed set practical guidelines based systematic review literature furthermore determined level evidence associated recommendations answer article suggest answers core questions medical treatment
trend toward competitive strictly environmentally regulated electricity market several countries including china led efforts industry government develop advanced performance evaluation models adapt new evaluation requirements traditional operational environmental efficiency measures fully consider influence market competition environmental regulations thus sufficient thermal power industry evaluate operational performance respect specific marketing goals operational effectiveness environmental performance respect specific emissions reduction targets environmental effectiveness complement operational efficiency measure operational effectiveness measure reflects capacity electricity production system increase electricity generation improvement operational efficiency also reflects systems capability adjust electricity generation activities match electricity demand addition complement environmental efficiency measure environmental effectiveness measure reflects capacity electricity production system decrease pollutant emissions improvement environmental efficiency also reflects systems capability adjust emissions activities fulfill environmental regulations furthermore environmental effectiveness measure helps government regulator verify emissions reduction targets assigned thermal power industry several newly developed effectiveness measurements based data analysis utilized study evaluate operational environmental performance thermal power industry china efficiency effectiveness evaluated three perspectives operational environmental joint adjustments electricity production system operational environmental performance changes time also captured effectiveness measure based global productivity index empirical results indicated performance chinas thermal power industry experienced significant progress study period policies regarding development regulation thermal power industry yielded expected effects however emissions reduction targets assigned chinas thermal power industry loose conservative elsevier ltd rights reserved
nowadays distributed denial service becomes major challenge network affects network multi level leads traffic overhead bandwidth utilisation order overcome issues ant based detection technique using virtual proposed technique virtual along multi level secure architecture used collect information various different levels network ant colony optimisation technique used detect based considered area multi level log table used detect different levels network affected area found information sent multi level architecture limit spread affected area information sent make defence system attackers advantage proposed technique provides full defence multi level without creating traffic overhead
objective objective study identification hif alpha using image cytometry help count positive cells hif alpha negative cells without hif alpha sample method images renal tissues male rats lineage overall objects cells images analysis acquired images analyzed free version version software separation classes object using classifier classes class hif alpha class without hif alpha results data obtained score possible calculate percentage cells objects sample hif alpha hif alpha data specificity standard deviation conclusion research shows free software light microscope able identify perform machines learning subsequently count separate cells distinct classes without hif alpha elsevier rights reserved
study investigated structural behavior long span partially earth anchored cable stayed bridges main span length use new key segment closing method based thermal technique detailed construction sequence analysis matched free cantilever method performed using three dimensional finite element model partially earth anchored cable stayed bridge new method offers effective way connecting key segments avoiding large movements resulting removal longitudinal restraint owing asymmetry axial forces near new method develops new member forces process heating cantilever system installing key segment cooling system continuously installing key segments resulting forces developed thermal process enhance structural behavior partially earth anchored cable stayed bridges owing decreased axial forces
paper presents novel fixation prediction modeling framework based inter image similarities ensemble extreme learning machines proposed framework inspired two observations contextual information scene along low level visual cues modulates attention influence scene eye movement patterns caused scene former visual experience motivated observations develop framework estimates given image using ensemble extreme learners trained image similar input image retrieving set similar images given image predictor images retrieved image set using resulting ensemble given image measured terms mean predicted value members elsevier rights reserved
studying vibration bridge vehicle coupled system researchers mainly focus vertical vibration bridges moving loads lateral longitudinal vibrations bridges stochastic characteristics traffic flows neglected however long span suspension bridges bridges three dimensional vibrations stochastic traffic flows cause considerable predicting dynamic performance study mainly focused establishing new methodology fully considering suspension bridges vertical lateral longitudinal vibrations induced stochastic traffic flows varied road roughness conditions new full scale vehicle model degrees freedom developed predict longitudinal lateral vibrations vehicle improved cellular model considering influence next nearest vehicle introduced bridge vehicles traffic flow coupled equations established combining equations motion bridge vehicles using displacement relationship interaction force relationship patch contacts numerical simulations show proposed method simulate vibrations suspension bridge stochastic traffic flows
differential evolution research multi objective optimization divided proposals either consider stand alone algorithm see algorithmic component coupled algorithm components general evolutionary multiobjective optimization literature contributions latter type shown components greatly improve performance existing algorithms however several experimental factors left type algorithm design compromising work revisit research effectiveness multi objective optimization improving several ways particular conduct iterative analysis algorithmic design space considering environmental selection components factors results show great level interaction algorithm components indicating effectiveness depends combined designs present state art performance confirming effectiveness multi objective optimization
simple accurate scheme modeling microstructures proposed help element combined signed distance function based boundary smoothing accommodate randomly distributed fibers unidirectional composites digital image processing used interfaces multi materials identified introducing signed distance function square background elements crossing interfaces simply divided represent single material behavior single element element elements shaped two dimensional domain split conventional three node triangle elements six node elements three dimensional domain available many commercial software packages present modeling scheme verified benchmark examples terms accuracy efficiency applied modeling unidirectional composites based real microscopic images evaluate equivalent elastic properties elsevier ltd rights reserved
study applies band ratios examine vegetation density vegetation health assess drought conditions nearly years district province using sequence landsat imagery research area distinctive climate characterized arid areas adjacent drought likely intensified rain shadow effects central part son positioned immediately west province seasonal land surface temperature normalized difference vegetation index calculated derive three indices vegetation condition index temperature condition index vegetation health index results show approximately two thirds district influenced mid severe drought dry season november following april severity drought increased intensively extensively toward north hypotheses testing correlation also revealed significantly negative relationship increasing surface temperature decreasing validate results applied procedure generating modis data despite absence historical datasets region landsat data shows many advantages monitoring drought remote small areas compared modis research strategies effective regions without sufficient climatic records conventional climatic analysis
background overview meeting explore ways expand access oral health care possibly expanding dental benefit medicare group four factors motivated meeting need older americans fastest growing segment population medicare dental care lack dental insurance growth social capital groups outside already working expand access strong support collective action moral imperative agreed senior experience pain poor diet loss self esteem inability pay oral health care improved health economic savings private discovered significant net savings achievable general health costs dental care provided people certain systemic diseases practical implications model medicare dental benefit presented generated much discussion agreement dental benefit attract participating agreement also reached importance public demonstration projects establish cost savings dental care patients comorbid diseases need collaborate advocacy policy groups establish overall health benefits gained adding oral health care necessity oral health literacy campaigns working directly community level general public others including educators media policy makers providers health fields levels professional training
mediated alternative pathway plays important role protecting wheat seedlings drought stress excessive reducing equivalents generated photosynthesis alternative pathway proven involved responses various stresses however mechanisms defense response drought stress still lacking aims work investigate role drought tolerance induced drought stress using two wheat cultivars different drought tolerance results showed cultivar tolerant drought cultivar seedlings exposed drought led significant increase increased furthermore chlorophyll fluorescence parameters broken vertical bar decreased significantly drought treated seedlings especially indicating occurred drought stress pretreatment sham activity photosynthetic efficiency inhibited drought treated seedlings resulting serious oxidative damage indicated higher levels malondialdehyde hydrogen peroxide moreover modulated drought stress increasing expression pyruvate content taken together results indicate mediated involved optimizing photosynthesis drought stress avoiding reduction photosynthetic electron transport chain thus reducing reactive oxygen species production oxidative damage wheat leaves
article explore different roles knowledge sharing learning play employees innovative behaviour investigate different moderating effects employees national cultural values relationship learning innovative behaviour chinese enabled global service firms different propose theoretical model characterize antecedents innovative behaviour structured research survey conducted data collected sample full time employees enabled global service firms results indicate knowledge sharing positively associated innovative behaviour private enabled global service power distance significant positive moderating effect learning innovative behaviour relationship state owned private firms significant moderating effect state owned firms china last explore implications findings theory practice innovation
architects around world search new forms buildings many interesting shapes derived geometry theory surfaces among minimal surfaces discovered deserve special attention due values one kind turns especially suitable shaping buildings present paper makes use parameterization construct surfaces explicit formulae selected surfaces implemented symbolic computation software upon models cad system one obtains possibility designing ready use engineering practice authors published elsevier ltd
intrusion detection system using increasingly used technique intrusion detection recovery data disrupted paper presents survey intrusion detection system different techniques mostly useful identify zero day attack listed table focus basic ideas based network security tools ids ids using plays important role finding source attack types attack provide result signature attack investigators prevent kind attacks future
background published human studies investigating whether use commonly used medication treatment common type inflammatory arthritis adults beneficial effects ventricular electrophysiology objective study assess whether use associated reduction risk ventricular arrhythmias methods used random sample medicare beneficiaries examine new use risk incident multivariable cox regression analyses adjusted demographics age race sex comorbidity cardiac medications conditions associated calculated hazard ratios confidence intervals results episodes new use associated incident among patients incident male white underlying diagnosis mean comorbidity score crude incidence per person days declined duration use increased days days years years analyses compared non use use associated lower compared non use longer use durations significantly associated lower multivariable adjusted days days years years multiple sensitivity analyses adjusting cardiac conditions anti drugs alternate definitions confirmed findings minimal attenuation estimates conclusion use use duration months independently associated lower risk future studies need assess pathophysiology potential benefit
reaction play important role chemical engineering calculated substance properties compounds involved reaction since substance properties usually come measurements always uncertainty uncertainty input data causes uncertainty simulation results even model perfect effect input uncertainty uncertainty equilibrium calculations studied monte carlo sampling applied accessing uncertainty probability density distribution uncertainty equilibrium conversion high however shape curve equilibrium conversion temperature predicted precisely consequence simulations reaction still useful temperatures required achieving certain conversion determined comparatively high accuracy probability density distributions obtained strongly input data cases even become elsevier rights reserved
article focused construction bim based schedule management system construction industry system exerts advantages visualization collaboration management construction schedule management bim model subdivided meet management demand construction phase linking subdivided model time parameters visual manage construction schedule achieved system provided paper enables project participants join schedule management visualization models workers get corresponding information effectively enhance control project schedule management
repeat surgery initial intervention sometimes needed reconstruction surgical bed adds level intraoperative complexity benefit preoperative intraoperative definitions biometric aesthetic norms computer assisted design manufacturing using imaging allows precise formulation operative plans anticipation surgical intervention printing turns virtual plans anatomical templates customized implants using variety materials authors present technical note illustrating use technology repeat reconstruction planned executed using computer assisted design printed intraoperative guides
study series laboratory experiments performed firstly analyze characteristics pore structure low rank coal poor development fractal features pores pores defined calculated using fractal dimensions respectively positive correlation moisture content positive correlation fixed carbon negative correlation volatile content weaker association ash yield apparent relationship coal indicating coal forming materials environments little influence pore structure fractal characteristics strongly correlation bet surface area average pore diameter proving used characterize pore structure fractal dimension pores shows negative correlation langmuir volume apparent relationship langmuir pressure indicating pore structure absorbed pores little effect methane desorption process exploitation weak positive correlation permeability overall fractal analysis beneficial better understanding pore structure methane ability low rank coal elsevier ltd rights reserved
incremental computation broadly applied computer software field needs complex algorithm design software maintenance develop incremental computation program automatic generation method according characteristics language method implement program transformation generate incremental computation program code automatically light input data modification computation obtain new result based original one execution performance incremental computation program better
neuroblastoma predominantly characterised chromosomal rearrangements next myc avian viral oncogene neuroblastoma derived homolog amplification chromosome gains frequently observed identified neuroblastoma patient regional gain encompassing enhancer gene histone methyltransferase lysine histone forms catalytic subunit complex commonly associated silencing genes involved cellular processes cell cycle regulation cellular differentiation cancer high expression correlated poor prognosis overall survival independent amplification status unexpectedly treatment high expressing neuroblastoma cell lines specific inhibitors resulted slight arrest despite maximum histone methyltransferase activity inhibition furthermore colony formation cell lines treated inhibitors reduced concentrations much higher necessary complete inhibition histone methyltransferase activity knockdown complete protein three independent resulted strong apoptotic response decreased cyclin levels apoptotic response rescued overexpressing truncated form wild type lacking set domain necessary histone methyltransferase activity findings suggest high expression least neuroblastoma survival function independent methyltransferase activity important finding highlights need studies beyond methyltransferase function requirement compounds target complete protein elsevier ltd rights reserved
examined different kinds rating formats interaction purposes rating administrative developmental induced different performance rating processes consequences rating accuracy two experiments participants rated seven targets presented via using modes rating giving access descriptive knowledge rating scales targets observable behaviors descriptive behavior evaluative knowledge rating scales others behaviors target tended afford evaluative behavior mix two knowledge types rating scales traits indexes within accuracy differential elevation differential accuracy collected results showed rating scales led higher differential elevation modes rating whereas rating scales led higher within modes results indicate rating scales suited comparing different administrative purpose rating whereas scales suited identifying strengths weaknesses particular developmental purpose experiments first apply dual knowledge descriptive evaluative theory performance appraisal context examine rating purpose interaction two forms person knowledge results consistent theoretical predictions indicate using rating scales different types content function rating purpose produce appropriate performance ratings
last decade witnessed proliferation neuroimaging studies brain changes associated alzheimers disease widespread atrophy signature brain regions implicated parallel prolonged latency period established abnormal cerebral changes beginning many years symptom onset raises possibility early therapeutic intervention even symptoms treatments greatest effect disease course modification two important accurate characterisation risk stratification monitoring progression using neuroimaging outcomes surrogate biomarker without symptoms develop referred preclinical structural neuroimaging modalities used identify brain changes related risk factors familial genetic mutations risk genes example apolipoprotein epsilon allele family history review structural imaging findings preclinical overall literature suggests early vulnerability characteristic regions medial temporal lobe structures precuneus white matter tracts corpus conclude structural markers promising research validation studies needed future secondary prevention trials adopt structural imaging biomarkers either stratification surrogate biomarkers elsevier rights reserved
facilitating fish passage fragmented river systems commonly focused commercially important migratory species increasingly ecosystem based approaches river rehabilitation adopted progressively designed fish barriers fish movement received less attention barriers regards refinement fish passage study evaluated fish passage pair distinct vertical slot large vertical slot max velocity max turbulence discharge small vertical slot max velocity max turbulence discharge low level barrier terminus river australia paired day samples fish species sampled large vertical slot compared fish species small vertical slot small fish large species rare species composition similar species specific varied widely large vertical slot successfully passed broad range species sizes passage several small length species partially whilst passage efficiency high species entered small vertical slot variation head differential subsequently hydraulics influenced number fish sampled entrance small vertical slot number fish sampled exit large vertical slot however facilitated passage diverse migratory fish across range head differential experienced suggesting application paired vertical slot differing hydraulic characteristics likely viable approach low level barriers elsevier rights reserved
control based continuation technique tracking solutions nonlinear experiments idea apply method numerical continuation feedback controlled physical experiment control becomes non invasive since experiment generally possible set state system directly control target becomes proxy state control based continuation enables systematic investigation bifurcation structure physical system much like numerical model however stability information hence bifurcation detection classification readily available due presence feedback control paper uses periodic auto model exogenous inputs approximate time varying experiment around particular periodic orbit thus providing missing stability information method demonstrated using physical nonlinear tuned mass damper authors published elsevier ltd open access article license
proposed model control based static model equation converter able change bias value corresponding changes load current input voltage output voltage model control regulate output voltage hand transient response output voltage improved therefore improvement transient response carried adding transient improvement function changes bias value drastically short time start transient state purpose paper indicate parameter setting transient improvement function improves transient response simulation analysis changing circuit condition
quantifying spatial genetic structure key inform forest management restoration strategies reliable evaluations genetic structure require sound sampling schemes inappropriate sampling estimate spatial patterns genetic structure sampling bias investigated computer simulations mostly animal species continuous distributions tree species different life history traits results studies apply used spatially explicit landscape genetic simulations assess effects spatial sampling scheme random systematic cluster sampling intensity number microsatellite loci inferences genetic structure isolation distance ibd two forest tree species varying dispersal distances distributions results showed random sampling loci best performing sampling scheme irrespective sampling intensity strength ibd contrast cluster systematic sampling sensitive sample size three sampling schemes number loci large effect loci increasing chance ibd increasing number samples number loci improve performance sampling schemes hence researchers put effort increasing number loci increasing sample size results also showed sampling error rates varied species sampling bias appeared stronger species aggregated spatial distribution
aerodynamic aeroelastic flutter driven successfully used harvest broadband airflow energy unit component flutter membrane consists thin free standing electrodes covered sides poly chloride structured provide advantageous surfaces specifically increase friction area airflow induced power generation single unit flutter membrane based mild airflow condition use multi layered fabricated simply single units improve output performance device separate configuration designed novel structure mounting aeroelastic flutter belt adapted use energy rubber belt flutter membranes created rapid periodic mode via aeroelastic synergistically harvesting energy application constant air stream closed channel thus flutter approach creates sustainable cost efficient energy harvesting system collecting broadband airflow energy furthermore aerodynamic aeroelastic great potential used numerous areas self powered electronic systems situ wireless sensor applications aircraft
valuable phenolic compounds synthesized plants via pathway synthase directly catalyzes formation currently lack information biosynthetic pathway derivatives detected roots analyzed seasonal variation spectrum content different ages one tree hplc analysis revealed presence nine cis cis cis present amounts dry weight present traces compounds highest total content detected one year old collected autumn spring previously cloned sequenced full length four transcripts study presents detailed analysis seasonal variations transcript levels different ages using qrt pcr transcription higher collected autumn spring summer winter actively transcribed ages collected winter spring summer expression significantly change year depend age therefore data show high levels expression present elsevier ltd rights reserved
background purpose detection igg igg now critical diagnostic criterion spectrum disorder evaluate patients based new diagnostic criteria using new house cell based assay methods generated stable cell line using internal entry site containing vectors allow simultaneous expression two proteins green fluorescent protein separately rna transcript performed house using serum patients patients diagnosed according new diagnostic criteria without igg high risk patients presenting core clinical characteristics fulfilling dissemination space patients neurological diseases including multiple sclerosis definite high risk patients also tested using commercial kit identical serum evaluate correlation methods assays performed two independent blinded investigators results house assay yielded specificity sensitivities detecting definite high risk patients respectively comparison commercial kit revealed correlation patients correlation present patients using commercial method seropositive using house method patients seropositive using commercial method using house method conclusions results demonstrate house highly specific sensitive method detecting igg patients
gene widely used selective antibiotic marker control resistance significantly increase tolerance hosts marine extremely sensitive selected selective marker genetic transformation cells density cells digested accounted total placed downstream promoter isolated yielding recombinant expression construct construct transferred transformed cultured fresh liquid medium selected solid medium supplemented pcr result proved existed transformants three transformants cultured least generations without losing southern blotting analysis showed integrated genome serve new dominant selective marker genetic engineering
paper presents new strategy online robust control based fractional order pid controller technique suggests online parameters tuning using reference iterative tuning approach approach enables track desired optimal parameters online using experimental data without plant model identification set optimal non integer orders gains estimated recursive manner using called recursive least squares algorithm factor cope variation plant characteristics adaptively performances technique compared results already existing literature typical examples results proposed approach show significant performance improvement
twenty one populations individuals covering entire native range mountain investigated genetic variation scored nuclear microsatellite markers main objective present study determine genetic structure across present distribution species locate populations different genetic compositions genetic variation observed within populations assignment populations based bayesian clustering methods revealed populations form separate genetic cluster stands likely established effects migrants distribution level polymorphisms along evidence isolation distance structure indicate present populations relatively recently originate larger distribution species one peripheral stand italy lowest values calculated genetic variation indices stand therefore susceptible genetic drift negative impact predicted environmental changes discuss findings respect previously published results genetic morphological variation consideration conservation genetics species
recent years online social networks become part everyday life millions individuals also data found fertile field analyzing user behavior individual collective levels academic commercial reasons hand many risks user privacy information user wish remain private becomes evident upon analysis however data make safe publication public domain information inevitably lost respect original version significant aspect social networks local neighborhood user associated data current techniques good identifying risks minimizing good maintaining local contextual data relate users social network thus improving aspect high impact data utility social networks also lack systems facilitate work data type data structures performing empirical experiments controlled manner different datasets hence present work address issues designing implementing sophisticated synthetic data generator together processor strict privacy guarantees takes account local neighborhood done complex dataset fitted real dataset terms data profiles distributions empirical section perform experiments demonstrate scalability method improvement terms reduction information loss respect approaches consider local neighborhood context elsevier ltd rights reserved
paper deals problem securing configuration phase internet things iot system main drawbacks current approaches focus specific techniques methods lack cross layer vision problem smart environment iot device limited resources often battery operated limited capabilities consequence network security carefully analyzed order prevent security privacy issues paper analyze iot threats propose security framework device initialization show physical layer security effectively boost security iot systems
purpose work describe possibility installation wave converter mediterranean sea paper present design electrical generator particular wave linear permanent magnet generator make wave energy converted electrical energy
recently using compressive sensing drawn attention due low complexity sampling process however applying images protect privacy image keeping efficiency becomes challenge paper propose novel image coding scheme achieves combined compression encryption parallel compressive sensing framework sampling reconstruction performed parallel way efficiency guaranteed hand security resistance chosen attack realized help cooperation nonlinear chaotic sensing matrix construction process counter mode operation furthermore defect energy information leakage based also overcome diffusion procedure experimental analysis results show scheme achieves effectiveness efficiency high security simultaneously elsevier inc rights reserved
water regarded poor absorber solar energy affects efficiency solar thermal systems addition nanoparticles heat transfer fluids used solar thermal systems enhance optical properties new generation heat transfer fluids known present study investigates stability optical properties three including aluminum oxide titanium dioxide stability observed photo capturing method zeta potential measurements ultraviolet visible vis used measure absorbance prepared effect factors type particle type surfactant solution optical properties also investigated found titanium dioxide better optical properties lower stability compared aluminum oxide
paper presents electronically tunable versatile voltage mode filter three inputs five outputs employing five operational transconductance amplifiers two grounded capacitors one grounded resistor use grounded capacitors makes circuit highly suitable integrated circuit implementation proposed filter simultaneously realize low pass band pass high pass band stop pass voltage responses appropriately connecting input output terminals natural frequency quality factor controlled inverting type input signals required realizing filter responses incremental sensitivities low pspice simulation results given confirm presented theory
predictive framework evolution stem cell biology currently lacking study propose deep image informatics nuclear biology stem cells elucidate biomaterials stem cell lineage phenotypes approach based high content imaging informatics capture minute variations spatial organization splicing factor marker classify emergent cell phenotypes human mesenchymal stem cells cells cultured varied culture systems including salt scaffolds approach encompasses high resolution imaging domains high content image analysis compute quantitative nuclear metrics organization single cells machine learning approaches construct predictive cell state classification model findings indicate cultured collagen induced differentiate osteogenic lineages classified three lineages stem osteogenic precision sensitivity within using framework augmentation scaffold design exerted scaffolds also within similar high sensitivity furthermore employing organizational metrics differential induced novel fibrous polymer incorporating matrix also elucidated modeled just days high precision demonstrate organizational metrics applied model stem cell state scaffolds propose methodology robustly minute changes stem cell states within complex architectures map single cell biological critical assessing population level cell heterogeneity statement significance sustained development validation bioactive materials relies technologies cell response dynamics biomaterials capturing cell cell heterogeneity preserving cellular native phenotypes study illustrate application novel high content image informatics platform classify emergent human mesenchymal stem cell phenotypes diverse range scaffolds high sensitivity precision track cell responses varied external stimuli major silico innovation proposed image profiling technology based unique three dimensional signatures protein within nuclei stem cells cultured scaffolds technology accelerate pace high fidelity screening inc published elsevier ltd rights reserved
rationale idiopathic pulmonary fibrosis ipf chronic fatal lung disease prognosis cure potential role ubiquitously expressed domain containing tyrosine phosphatase therapeutic target studied ipf objectives determine expression mechanistic role potential therapeutic usefulness pulmonary fibrosis methods effects overexpression inhibition fibroblast response stimuli analyzed vitro primary human mouse lung fibroblasts vivo therapeutic effects assessed bleomycin model lung fibrosis administration transgenic mice carrying constitutively active mutation measurements main results regulated lungs lung fibroblasts obtained patients ipf studies revealed absent within foci loss expression activity sufficient induce fibroblast differentiation primary human lung fibroblasts overexpression constitutively active reduced responsiveness stimuli including significant reductions cell survival differentiation effects mediated fibrosis relevant tyrosine kinase serine threonine kinase signaling pathways mice carrying syndrome associated gain function mutation resistant bleomycin induced pulmonary fibrosis restoration levels vivo delivery blunted bleomycin induced pulmonary fibrosis conclusions data suggest important regulator fibroblast differentiation loss observed ipf facilitates phenotypic changes augmentation activity expression investigated novel therapeutic strategy ipf
future next generation computing platforms dependent development active devices compensating high losses metallic present investigate gain characteristics electrically amplifier design wavelength finite difference time domain simulations device shown capable coupled network restoring signal amplitude hundred propagation ghz pulse repetition rates maintained without significant pulse distortion offering possibility incorporating bandwidth hybrid optical electrical circuits
transgenic animals potential applications medicine life sciences study developed convenient economic efficient method gene transfer transfection male stem cells three fragments gene encoding antibacterial peptide synthesized amplified overlap extension polymerase chain reaction pcr inserted vector plasmid mixed injected testes male mice minimally invasive operation six weeks injection male mice normal female mice produce generation pcr southern blotting performed analyze mice among mice produced found positive gene pcr southern blotting six positive mice selected generation normal females generation found positive gene expression green fluorescence protein transgenic mice confirmed fluorescence imaging results showed gene integrated mouse genome study provides useful method future development disease resistant animals production antibacterial peptides transgenic animals elsevier inc rights reserved
previous studies reported young participants typically date events remember longer believe experienced period childhood present study investigated whether participants aged years events related memories period childhood younger people whether events period later life study also compared believed memories respect memory perspective person perspective results indicated majority middle aged older people memories period childhood median age years correlation found participants current age age time event occurred addition results showed believed memories likely retrieved person perspective memories elsevier inc rights reserved
touch primary nonverbal communication channel used communicate emotions social messages despite importance channel still little explored affective computing field much focus placed visual channels paper investigate possibility automatically discriminate different social touch types propose five distinct feature sets describing touch behaviours captured grid pressure sensors features combined together using random forest boosting methods touch gesture type proposed methods evaluated gesture types different surfaces cost gesture types surface datasets made available social touch gesture challenge chance level performances achieved accuracy cost testing datasets respectively
solar energy research community realized redundancy image forming collecting solar energy discovery type radiation collection mechanism since various concentration mechanisms proven superior collection efficiency imaging counter parts feasibility using successfully stationary applications interest economic benefits appealing owing elimination tracking costs installation operation maintenance energy paper exhaustive review available mechanisms stationary applications mind paper also explores idea coupling passive solar tracking mechanism
highly thermally conductive heat fabricated layer layer first time prepared assisted liquid hexagonal powder prepared heat exhibits high thermal conductivity along plane direction enhanced annealing heat thickness possessed excellent thermal stability negligible weight loss wide temperature range degrees resulting promising applications heat dissipation electronic components operated high working temperature
study prototype site cyclic loading experiments carried reinforced constructed geotextile confirm stability reinforced ground experiment reinforced grounds methods constructed continuously site cycle loading given load vehicle ground results reinforcing effect combination geotextile similar combination geogrid
alzheimers disease patients display neuropathological lesions including accumulation amyloid beta beta peptide although mechanisms causing neurodegenerative process largely unknown increasing evidence highlights critical role immunity pathogenesis alzheimers disease present study investigated role regulatory cells alzheimers disease progression first explored effect cells cells transfer model systemic transplantation purified mice improved cognitive function reduced deposition beta plaques contrast transfer diminished behavioral function cytokine production next transiently depleted treg population using anti antibody depletion four months resulted marked spatial learning deficits six month old mice additionally resulted decreasing glucose metabolism assessed positron emission tomography pet glucose fdg neuroimaging importantly deposition beta plaques microglia macrophage increased hippocampal regions treg depleted compared vehicle treated group finding suggested systemic treg administration disease progression effective alzheimers disease treatment
article study classical single item economic lot sizing problem production cost functions assumed piecewise linear lot sizing problem fundamental lot sizing research applicable wide range production planning models problem related value number different production cost functions arbitrary problem known hard however fixed solved polynomial time far efficient algorithm solve problem complexity number periods planning horizon article present improved exact algorithm solving problem complexity reduced center dot log also improves upon computational efficiency solving existing lot sizing problems important special cases model order achieve efficient implementation algorithm makes use specific data structure named range minimum query elsevier rights reserved
schizophrenia considered disorder abnormal brain connectivity although whole brain maps averaged bivariate voxel correlations successfully applied study connectivity abnormalities schizophrenia maps adequately explore multivariate nature brain connectivity adapt novel method high dimensional regression supervised principal component regression estimate brain maps multivariate non redundant connectivity resting functional magnetic resonance imaging fmri data patients schizophrenia matched controls disorder related differences involved hyper connectivity hypo connectivity several cortical areas dorsal cingulate right cortex abnormalities coupled abnormalities amplitude signal fluctuations minor extent differences dimensionality connectivity patterns quantified number supervised principal components second level seed correlation analyses linked observed abnormalities additional set brain regions relevant schizophrenia thalamus temporal cortex non redundant connectivity maps proposed new tool complement information provided already available voxel based whole brain connectivity measures
work presents application power series method find solutions partial differential algebraic equations two systems index one index three solved show provide analytical solutions convergent series form present post treatment power series solutions laplace method useful strategy find exact solutions main advantage proposed methodology procedure based straightforward steps generate terms depends perturbation parameter
since european union antibiotic growth promoters research focused natural feed additives proven positive impact production animal health commonly used effective probiotic additive mechanism interactions avian body complex fully understood despite number unresolved issues many authors demonstrated positive impact host organism dietary supplementation poultry feeding contributes modulation intestinal microbiota quick proliferation beneficial lactobacillus strains inhibiting growth pathogenic microbes indications changes host gut microbiota poultry alter structure intestinal mucosa improve absorption capacity poultry also demonstrated affect immune system systemic metabolism minerals lipids reports effects body performance poultry often contradictory effectiveness strongly dependent type dose used duration administration
successfully grown cheap commercial pet substrate modified two step spin coating procedure solution small amount used found morphology behavior depended strongly amount zno thin films showed faster extraction electron usual thin film possibly due larger surface volume ratio better contact zno specific charge injection rate high achieved potential enhance performance flexible solar cell elsevier rights reserved
perfect absorber realized properties theoretically numerically experimentally investigated microwave frequencies addition polarization incident angle also tested structure theoretical numerical experimental results show proposed model many advantages compared literature perfect absorption polarization incident angle simple design operation sufficiently wide band simple configuration chosen proposed model easily tuned frequency regimes realize new applications sensors stealth technology
paper influence fetal glutathione transferase copy number variants adverse reproductive outcomes nested association study designed investigate influence maternal fetal copy number variants reproductive outcomes genotypes ten encompassing cyp genes assessed significant associations found child genotypes particular child insertion allele associated protection odds ratio whereas child insertion allele associated increased risk small gestational age odds ratio study highlights role fetal genome prenatal development also need analyse systematic manner
nowadays thermoelectric materials gained considerable attention due unique ability directly convert waste heat electricity vice versa long time researchers mainly focused developing high performance inorganic materials based alloys etc however inorganic materials various disadvantages high cost heavy metal contamination relatively poor etc compared inorganic materials poly great potential used materials due low thermal conductivity low cost low density etc therefore attention focused preparation properties based nanocomposites especially one dimensional based nanocomposites due nanostructures always enhanced properties article presents overview synthesis nanoparticles nanostructures corresponding nanocomposites properties elsevier rights reserved
dna methylation genes accurately regulated particular cpg methylation long elements particle characterized cpg methylation regulatory regions acquired embryonic testis development however reductions dna methylation gene observed deficient mice biogenesis concerning describe two methods sequencing southern blotting using methylation sensitive restriction enzyme analysis dna methylation genes mouse testes
current study determined ability cyclic peptide rescue cells beta amyloid beta induced death cells rat cortical incubated beta increasing concentrations cyclic peptide peptide ability beta binding determined duplicate cultures stimulated beta peptide ability beta binding interfere beta induced signalling rescue cells beta mediated toxicity determined immunoprecipitation northern blotting activation mtt blue assays peptide inhibited beta binding beta induced jun transcription treated cells cells cyclic peptide also peptide reduced beta induced protected beta induced toxicity determined blue exclusion assay blue positive cells pretreated cultures cyclic peptide pretreated cultures mtt assay units pretreated cells units cyclic peptide pretreated cells visualization representative microscopic fields data suggest cyclic peptide homologous amino acids known mediate binding interfere beta signalling rescue beta induced toxicity
learning programming inherently exploratory activity supporting process trivial task requires resources paper proposes utilisation intelligent exploratory learning environment enhance teaching learning context minimal cost
paper output error method proposed identification continuous time systems time delay sampled data challenge time delay system identification lies presence nonlinear time delays models starting value based optimization methods trapped easily local order improve convergence performance choice initial parameters several approaches smooth loss function presented shown loss function possess many local data regularly sampled inter sample behavior zero order hold interestingly irregular sampling efficient approach overcome local achieve superior convergence performance approach incorporating low pass filtering technique proposed convergence region theoretical simulated results presented demonstrate effectiveness proposed method elsevier rights reserved
children developmental express impairments acquisition various motor skills development social cognition abilities although neural bases condition fully understood thought involve frontal cortical areas subcortical structures cerebellum although cerebellar dysfunction typically difficult assess quantify using traditional neurophysiological methods analysis provide insight specific cerebellar patterns aim present study investigate typically developing subjects various tasks specifically designed reveal frontal cerebellar dysfunction addition evidence supporting prefrontal dysfunction results revealed increased variability accuracy consistent cerebellar impairments furthermore found patients showed decreased velocities non visually guided closer analysis revealed significant differences velocity profiles slightly decreased maximum velocities markedly prolonged phases show pattern related decreased state suggestive cerebellar dysfunction however clear predominance pattern non visually guided warrants alternative hypotheses light previous experimental anatomical studies propose unusual pattern consequence impaired connections frontal areas cerebellar structures
background eating disorders eds common amongst women however research specifically investigated lifetime month prevalence eating disorders amongst women mid life fourth fifth decade life relevant longitudinal risk factors aimed investigate lifetime month prevalence eds lifetime health service use identify childhood parenting personality risk factors methods two phase prevalence study nested within existing longitudinal community based sample women mid life total women longitudinal study parents children enrolled years earlier participated diagnoses obtained using validated structured interviews weighted analyses carried accounting two phase methodology obtain prevalence figures carry risk factor regression analyses results mid life confidence intervals women met criteria lifetime month prevalence eds childhood sexual abuse prospectively associated binge type disorders external locus control associated binge eating disorder better maternal care protective bulimia nervosa childhood life events interpersonal sensitivity associated eds conclusions mid life significant proportion women experience women accessed healthcare active eds common mid life due new onset chronic disorders increased awareness full spectrum eds stage life adequate service provision important first study investigate childhood personality risk factors full threshold sub threshold eds identify common predictors full sub threshold eds research clarify role preventable risk factors full sub threshold eds
article focuses effects operational differences case estimates prevalence incidence cognitive impairment dementia alzheimer type experience insights discussed investigators heart study east senior health project health aging project clinic study aging longitudinal study aging aging demographics memory study general consensus single important factor determining prevalence estimates alzheimers disease severity cognitive impairment used threshold define cases studies require level cognitive impairment persons unable provide self care much lower estimates studies aimed identifying persons earliest stages limited autopsy data aforementioned epidemiological studies address accuracy diagnosis etiological subtype namely specification alone combination types pathology however community based cohort studies show many persons mild cognitive impairment also persons without dementia mild cognitive impairment meet pathological criteria thereby suggesting number persons benefit effective secondary prevention intervention probably higher published prevalence estimates improved accuracy clinical diagnosis anticipated addition molecular structural biomarkers next generation epidemiological studies alzheimers association rights reserved
purpose aim study investigate two single nucleotide polymorphisms snp associations human muscle strength phenotypes healthy men methods measurement maximal voluntary knee extension torque net torque specific force using established techniques completed caucasian men age year height mass mean participants provided either blood cell sample dna isolated genotyped snps using real time polymerase chain reaction results genotype frequencies snps equilibrium specific force higher allele carriers higher allele carriers associations either snp net torque peak torque observed conclusions findings identify genetic contribution inter individual variability within muscle specific force provides first independent replication larger caucasian cohort association snps muscle specific force thus extending understanding influence genetic variation intrinsic strength muscle
paper examines recipients social work support cohort study using panel analysis fixed effects models investigates factors lead receipt type social work support individuals young children effects support changes prevalence emotional behavioural problems children find separation episodes two important factors lead receipt social work support mothers male children also likely receive social work support however find clear evidence social work support effect changes childrens emotional behavioural problems time implications findings social work research practice policy discussed
diagnosis management attention deficit hyperactivity disorder adhd adults complex challenging frequent comorbidity psychiatric disorders symptoms overlapping adhd presence comorbidities create challenges making accurate diagnosis also impact treatment options outcomes review discusses disorders comorbid adhd adults including anxiety mood substance use disorder antisocial personality disorder borderline personality disorder suggestions recognizing comorbidities distinguishing adhd perspectives possible impact adhd treatment included adjunctive modalities especially helpful case comorbid mood anxiety substance abuse personality disorders
satellite systems offer several advantages wireless internet communications nevertheless satellite radio links affected two severe problems namely long propagation delays relatively high error rates pose difficult challenge internet protocols particular tcp among potential solutions specifically interested tcp enhancements preserve end end semantics tcp paper authors evaluate performance improvements provided additional features applied tcp west wood promising transport protocol specifically designed cope errors wireless links enhanced version compared original known tcp variants considering fairness performance figures results obtained simulations seem encouraging suggest inclusion proposed additional features future official versions
background although common disease lack understanding underlying molecular mechanisms behind initiation progression used combined mirna mrna transcriptome analysis discover dysregulated genes networks methods fourteen fresh frozen samples one human cell line analyzed using mirna whole transcriptome microarray chips data filtered analyzed candidate mirnas mrnas selected validation fifty eight patient samples mirna target mrna relationships assessed inhibiting mirna cells apoptosis viability assays also used functional tests results whole transcriptome microarray genes found dysregulated mirnas found dysregulated result mirna microarray results combined analyzed bioinformatics tools top differential pathways included inflammation cancer cellular growth survival constitutively low samples moreover negatively correlated mir samples inhibiting mir upregulated level induced apoptosis cells decreased cell viability mir correlated clinicopathological features patient samples conclusions results present first integrated mrna mirna analysis mir inversely correlated tissues cells regulated mir furthermore determined potential clinicopathological markers
cipher system sources distortion allowed legitimate considered source compressed using rate distortion code satisfies constraint compression rate constraint exponential rate excess distortion probability legitimate measured exponential rate distortion probability rather traditional measure perfect exponent defined maximal distortion exponent achievable key rate reproduction based estimate exponent defined maximal distortion exponent achievable aided secret key limited key rate proved maximal achievable distortion exponent equal minimum key rate plus reproduction based estimate exponent perfect exponent result generalized fairly general class variable key rate coding rate codes
study done investigate osteoporosis prevalence hip fracture admissions trauma unit university hospitals associated factors understudied locality prevalence female sex older age low body mass index fall ground associated osteoporosis purpose study aims identify osteoporosis prevalence hip fracture admissions trauma unit university hospitals study independent correlates osteoporosis related fracture methods prospective cross sectional study carried hip fracture patients admitted trauma unit university hospitals january december sexes aged years older exclusion criteria major accidents history chronic conditions long term medication associated osteoporosis risk increase bilateral hip fractures every patient weight height bone mineral density dual energy ray absorptiometry recorded tests significance non parametric data used questionnaire included sociodemographic characteristics dietary habits lifestyle factors smoking physical activity female obstetric factors results mean age males obese fall ground fractures osteoporosis femoral neck prevalence analysis significant correlates female gender older age normal bmi fall ground milk daily intake significantly associated lower prevalence osteoporosis multivariable logistic regression model female sex older age low bmi fall ground associated osteoporosis conclusions osteoporosis prevalence high among hip fracture patients associated female sex increase age low bmi fall ground strategies prevent osteoporosis needed decrease hip fracture rates
background patients inflammatory bowel disease ibd irritable bowel syndrome ibs access growing number probiotic products improve digestive health unclear patients make decisions probiotics role expect play consider using probiotics understanding patients knowledge attitudes expectations probiotics help engage patients collaborative discussions probiotics study focus groups conducted patients ibd ibs clinic clinic university inductive analytic methods used identify common themes draw interpretations focus group narratives results one hundred thirty six patients participated focus groups march august patients viewed probiotics appealing alternative pharmaceutical drugs understood probiotics natural low risk therapeutic option many patients use without patients risks benefits probiotics disease severity satisfaction current treatments considering probiotic use conclusions patients interested probiotics many unanswered questions use findings suggest patients ibd ibs look clinicians trustworthy regarding utility probiotics alternative supplement pharmaceutical drugs clinicians care patients diseases prepared discuss potential benefits risks probiotics assist patients making informed decisions use
surface electrical charge excited metal surface light provide means optical energy converted electrical energy manipulated nanoscale surface propagate waves devices exists metal nanoparticles circuits developed mimic based optical circuit devices metal nanoparticles excitations electrical circuits although surface electrical nature preserve phase coherence incident optical fields regard surface devices represent convergence optics electronics paper review work two fields discuss progress towards devices nanoscale control optical signals optical signal processing
anti inflammatory antibacterial analgesic drug widely used treat several diseases reported literature effect collagen deposition abnormal tissue study aimed investigate possible therapeutic effects hypertrophic formation rabbits twenty four new zealand male rabbits randomly divided four groups control sham except control group biopsy defects created animals right ear following hypertrophic formation day administered week weeks groups respectively therapeutic agent administered control sham groups one week last injection ear samples collected histopathological immunohistochemical real time polymerase chain reaction gene expression analyses histopathological examination revealed epithelium group control groups thinner sham group connective tissue thickness level sham group higher control groups collagen type immunoreactivity level sham groups higher control groups collagen type iii immunoreactivity level higher sham group groups collagen type type iii immunoreactivity ratios lower group alignment collagen fibers normal group irregular sham groups collagen type gene expression levels groups lower sham group collagen type iii ifn gamma mrna expression levels almost similar among groups tgf beta mrna expression levels higher groups control sham groups basis results concluded administration decreases hypertrophic formation easily safely british association plastic aesthetic surgeons published elsevier ltd rights reserved
embryonic development animals like birds mammals transition occurs especially species taxa based evolutionary aspects development review focuses prenatal development system using model final incubation embryos respond environmental temperature influences nearly appropriate way autonomic neuronal molecular mechanisms underlying development established transition system control system without feedback system feedback mechanisms occurs embryos incubation temperature decreases normal level seems associated metabolism increased incubation temperatures embryos able stabilize body temperature therefore normal temperatures occur limited temperature range elsevier rights reserved
economic societal costs urban heat island considered marginal effect temperature increase device efficiency lifespan urbanization virtually human comfort systems efficiency systems subject degradation urban heat island simplest way model degradation application ideal device efficiencies results analysis presented considered paper magnitude costs avoidance potential mitigation avenues principal topics work technical underpinnings approach presented supplementary material available online self reinforcing nature economic scale urban heat island effect thus approached first principles thermodynamics available data relevant devices systems global perspective phenomenon presented followed case study metropolitan area demonstrate scale effects analysis thermodynamic economic approaches health policy issues urban heat island particular consideration given planning minimization effects low middle income urban areas study first estimates costs borne today large urban centres highlights risks secondary cities eventually face potentially mitigate undergo rapid growth
offenders antisocial personality disorder aspd characterized lack emotional functioning manifests irritability lack proposed link aspd negative led question emotional processing anomalies aspd furthermore effect childhood maltreatment abuse emotional processing tested present study violent sexual offenders aspd without aspd healthy non criminal controls compared emotional task est using neutral negative violence related words secondary analyses focused effect psychopathic traits childhood maltreatment offenders aspd showed stronger attentional bias violence related negative words compared controls comparable results obtained grouping offenders high medium low psychopathic subgroups offenders childhood maltreatment specifically showed stronger violence related attentional bias non offenders data suggest enhanced attention violence related stimuli adult criminal offenders associated adverse developmental experiences lesser extent antisocial psychopathic traits elsevier ireland ltd rights reserved
known paper proposed counter intuitive explanation rise non marital births united states emphasized birth control abortion weakened responsibility men partners pregnancy paper regularly cited social support measures restrict sex education access contraception abortion argue use papers findings stems specific modeling assumptions types women present model using reasonable types generates precisely results different policy implications
rivers ice sheet transport large volumes surface toward ocean yet received relatively little direct research study presents field observations channel width depth velocity water surface slope nine channels south western collected july august field sites located span elevation contain measured discharges larger previous situ study channels wide channels deeply near vertical banks hydraulic geometry results indicate channels primarily accommodate greater discharges increasing velocity smaller streams water surface slopes typical terrestrial settings yielding correspondingly high velocities numbers supercritical flow observed measurements derived values larger variable anticipated channels uniform substrate ranging mean value despite absence sediment debris roughness elements ubiquitous micro shallow sections channel bed explain roughness values however find sources flow resistance likely contributed elevated values future work explicitly consider additional sources flow resistance beyond bed roughness channels conclude hydraulic modeling channels allow supercritical flow importantly assuming ice substrate channels exhibit similar hydraulic behavior especially numbers finally study highlights theoretical empirical work channel hydraulics necessary broad scale understanding ice sheet achieved copyright john wiley sons ltd
morphological matrix method key legal point view main function program portfolio analysis combination good program list due combination lot number programs therefore difficult compare one one evaluation difficult get best program main problem lies expert system knowledge acquisition reasoning difficult intelligent design cars mechanical system actually instance reasoning matching process paper automotive intelligent design system based attempt improve efficiency product design system technology artificial intelligence expert system optimization design finite element analysis computer graphics various numerical calculation methods combine respective merits complement aim make computer much possible participate decision making structural design performance analysis graphics whole process
background childhood cancer survivors high burden chronic conditions related cancer treatment debilitating potentially life threatening much remains learned late effects bone soft tissue sarcoma survivors procedures cancer registry used identify survivors bone soft tissue diagnosed ages years least years diagnosis selected age sex matched comparison cohort hospitalizations extracted department health inpatient hospitalization discharge records cox poisson gamma regressions used evaluate risk hospitalization rate admission length stay survivors versus comparison cohort primary icd codes defined common reasons hospitalizations results hazard ratio hospitalization higher survivors reference comparison cohort confidence interval survivors experienced hospital admissions rate ratio longer length stay compared comparison cohort survivors treated chemotherapy three fold higher risk hospitalization compared survivors received surgery radiation alone among hospitalized survivors common reason injury bone tumor neoplasm soft tissue sarcoma conclusion childhood survivors bone tumor soft tissue sarcoma face ongoing risk hospitalization years diagnosis
follow studies disease event time subject left right furthermore medical advancements made possible patients cured certain types diseases article consider mixture cure model regression analysis left truncated right data model combines logistic regression probability event occurrence class transformation models time occurrence investigate two techniques estimating model parameters first approach based estimating equations second approach based conditional likelihood function given variables asymptotic properties proposed estimators established simulation studies indicate conditional maximum likelihood estimator performs estimator based unstable even though shown consistent special intriguing phenomenon approach cure model provide insights issue find approach improved significantly assigning appropriate weights observations finding useful overcoming instability approach complicated situations likelihood approach feasible illustrate proposed estimation procedures analyzing age onset wall distance event patients ankylosing spondylitis
order facilitate interaction communication enrich user experience general introduce novel textual emotion visualization approach grounded generative art approach centered idea affective computer systems able relate communicate human emotions maps emotions identified text abstract animation examined two visualizations based approach two common textual emotion visualization techniques along three dimensions emotion communication emotion overall user enjoyment study organized repeated measures within subject experiment demonstrated terms emotion communication visualizations comparable however main visualization based abstract color motion shape proved best emotions addition terms overall user enjoyment gave results comparable better
present random forest classification regression technique predict unified parkinsons disease rating scale improvement deep brain stimulation hypothesized data informed combination features extracted intraoperative recordings predict motor improvement parkinsons disease patients undergoing surgery modified employed account unbalanced datasets multiple observations per patient showed first time five signal features sufficient predicting improvement finding suggests nucleus electrophysiological signal characteristics strongly correlated extent motor behavior improvement observed
study designed tested novel type solar energy integrated vacuum membrane system seawater actual environmental conditions china system consists eight parts seawater tank solar collector solar inclined circulating water vacuum pump heat exchanger fresh water tank tank natural seawater used feed hydrophobic fiber membrane module used improve seawater experiment conducted typical summer day results showed highest ambient temperature degrees maximum value average solar intensity system able generate per membrane module fresh water day retention rate electrical conductivity average salt rejection proposed system shows favorable potential application waters high salt wastewater treatment
paper presents hydraulic actuator tendon drive system specifically designed lower limb provide high power low inertia dynamics actuator tendon system analyzed based system adaptive sliding mode trajectory tracking controller designed drive system stability proof indicates controller globally stable experimental results demonstrated controller provides high tracking accuracy robust external disturbances nonlinearities moreover controller less errors conventional pid controller tests included joints conducted verify performance controller
paper presents reliable machine vision system automatically detect determine broken unlike machining operations studied literature dealing edge milling head tools aggressive machining thick plates single pass studied cutting head tool characterised relatively high number makes key aspect identification broken critical proper tool monitoring system method propose first determine expected position orientation cutting edge applying geometrical operations compute deviations expected cutting edge real edge determine insert broken evaluated proposed method new dataset acquired made public obtained result harmonic mean precision recall shows machine vision system present effective suitable identification broken machining head tools ready installed line system
child abuse global public health problem serious social issue japan social support beneficial parents faced challenges aim study clarify association social support child abuse potential cross sectional study conducted using structured questionnaire target population mothers children nine public schools bivariate multiple linear regression analysis performed examine effects socio demographic social support psychological distress factors child abuse potential among mothers high child abuse potential score bivariate analysis indicated mothers higher child abuse potential score likely living single female parent households low perceived economic status low level child care support low multidimensional scale perceived social support score high general health questionnaire score important predictors child abuse potential among mothers surveyed included living single female parent households low perceived economic status low score high score improving approaches help mothers build social support relationships ease child rearing healthy condition recommended prevent child abuse elsevier ltd rights reserved
study used latent profile analysis develop coping year old mexican american adolescents three identified opposition coping adolescents tended use anger emotions support seeking coping adolescents relied seeking support escape opposition coping adolescents relied anger substance use coping behavioral avoidance peer support three key parental behaviors support knowledge psychological control mothers fathers adolescent gender examined predictors coping results indicated parental support knowledge particularly mothers predicted membership support seeking coping typology relative two girls likely boys utilize support seeking coping opposition coping gender socialization norms influenced results discussed
purpose work examine relationships geographical coordinates prevalence winter depression sad compare sleep characteristics youths without sad conducted cross sectional study self reported sleep characteristics winter depression northern european russia two questionnaires questionnaire seasonal pattern assessment questionnaire administered total adolescents aged males females prevalence sad study population sub sad four variables predicted likelihood sad youths sex higher females odds ratio age increases age latitude higher north position time zone higher west later sleeping longer sleep severe sleep inertia shorter total sleep times lower sleep efficiencies observed males females sad influence sad sleep characteristics pronounced school days significant phase delays sleep wake rhythm severe social difference mid point sleep phase observed females sad males significant differences sleep characteristics people sad sad demonstrate latitude residence location within time zone significant predictors sad young inhabitants north
effects video games childrens psychosocial development remain focus debate two year apart children years old male reported gaming frequency tendencies play violent video games game likewise parents reported childrens psychosocial health gaming time one associated increases emotion problems violent gaming associated psychosocial changes cooperative gaming associated changes prosocial behavior finally competitive gaming associated decreases prosocial behavior among children played video games high frequency thus gaming frequency related increases internalizing externalizing attention peer problems violent gaming associated increases externalizing problems children playing approximately per week frequent competitive gaming risk factor decreasing prosocial behavior argue replication needed future research better distinguish different forms gaming nuanced insight
early androgen exposure known long lasting effects phenotype behaviour even fitness difficulties measuring exposure hinders study importance evolutionary context digit ratios highlighted potential easy measure indicator early steroid exposure suggested reflect steroid mainly testosterone levels prenatal development however evidence digit ratios reflecting early steroid levels weak experimental studies especially wild populations scarce studied association derived androgens digit ratios using data rather high level experimental elevation androgens also examined whether digit ratios indicator value evolutionary context studying correlations digit ratios reproductive traits secondary sexual traits exploratory behaviour find association digit ratios androgen level either experimental data digit ratios neither related reproductive secondary sexual traits exploratory behaviour measured however sex difference adult birds due second fourth shorter females apparent raised suggests either sex difference develop late sexual maturation breeding results indicate species digit ratios reliable markers derived androgen exposure bear little relevance correlates adaptive traits measured
paper conduct research differences han chinese communication psychological characteristics cross cultural environment empathy process cross cultural communication subject good better means communication cross cultural communication improve sensitivity different peoples nations way eliminate communication barriers conflict achieve smooth language communication article use theory communication understanding traditional culture obstacles communication article two aspects language communication nonverbal communication process cross cultural communication problems analyzed meaningful
great importance many applications provide stable output power traveling wave tube long operation time several hours order achieve goal automatic hot test platform set power stabilization obtained adaptive scheme proportional integral derivative pid feedback beam current controlled heating power cathode anode beam voltage determined operating parameters pid controller adaptively adjust beam current voltage maintain output power target pid controlling process effectively eliminate influence power supply voltage surge cathode emission instability automatic hot test shows pid feedback controlling accuracy output power better
purpose abundant amino acid plasma plays key role maintaining integrity intestinal studies showed able modulate intestinal permeability tight junction protein expression several conditions recent articles putative beneficial role gastrointestinal disorders irritable bowel major nutrient maintain intestinal barrier function animals humans depletion results atrophy decreased expression tight junction proteins increased intestinal permeability moreover supplementation improve gut barrier function several experimental conditions injury clinical situations furthermore preventive effects experimental models intestinal injuries recently reported despite promising data experimental models studies needed evaluate supplementation clinical practice
long term goal virtual physiological human digital patient projects run simulations health disease processes virtual digital patient use results make predictions real health determine best treatment specifically individual termed personalized medicine intended future healthcare people interact engage virtual virtual models used motivate people actively participate healthcare discuss questions describe current efforts integrate models face face interaction increase engagement virtual humans healthcare overall paper highlights need attention design human machine interfaces address patient engagement healthcare
background glutamatergic system abnormalities implicated pathophysiology treatment major depressive disorder bipolar depression subsequent studies demonstrating rapid robust antidepressant effects methyl aspartate receptor antagonist glutamatergic modulators now studied clinical trials mood disorders previous open label study found administered combination mood lithium antidepressant effects methods conducted randomized double blind placebo controlled trial monotherapy treatment nineteen subjects aged years bipolar disorder currently experiencing depressive episode excluded medications randomized receive placebo weeks rating scale scores depression rating scale hamilton rating scale depression hamilton rating scale anxiety young mania rating scale obtained weekly results significant differences depressive symptoms observed subjects treated receiving placebo anxiety scores significantly lower placebo group analysis conducted resulted stopping study subjects achieved treatment response conclusions although found change severity depressive symptoms patients receiving compared placebo trial limited relatively high number subject small sample size thus monotherapy demonstrate efficacy studies examining adjunctive therapy disorder warranted
objective examine effects using cognitive find positive gains caregivers depressive symptoms burden psychological method ninety six caregivers persons alzheimers disease randomly assigned receive benefit finding intervention treatment usual conditions namely simplified lectures standard participant received interventions month period home results results showed benefit finding participants reported lower depressive symptoms treatment compared either participants also reported less role overload compared participants self efficacy controlling thoughts mediator treatment effects conclusion finding positive gains effective intervention reduce depressive symptoms among alzheimer caregivers
leak current channel regulates locomotion respiration intellectual development previous work highlighted striking similarities characteristic movement phenotypes deficient animals drosophila major symptoms parkinsons disease primary progressive gait discovered novel physiological connections channels gap junctions mediate regulation locomotion drugs block channels gap junctions activate channels significantly improve movement deficient animals loss function creates imbalance ions including normal cycles depolarization work suggests new therapeutic strategies certain human movement disorders wiley periodicals inc
orthogonal frequency division popular transmission format emerging wireless communication systems including satellite radio various wireless local area network standards digital broadcast television single carrier cyclic modulation similar frequency domain operations performed receiver systems employing perform presence provided channel delay spread shorter interval transmitted blocks condition met channel shortening used shorten channel desired length modestly time varying environments adaptive channel interest existing adaptive channel require channel away zero paper study use unit tap constraint rather unit norm constraint adaptive channel use constraint manipulate existing algorithms framework analogous recursive least squares algorithm develop adaptation rules blind frequency domain receivers simulations proposed algorithms show order magnitude improvement convergence speed reduced asymptotic bit error rate
article argue sustainable development possible without affordable inclusive growth inequality linked unless world able look environmental solutions affordable meet needs work
aiming problem fixed radio frequency identification system lightweight cryptography easily controlled communication authentication protocol based quantum key distribution using state method proposed developed study new system model using quantum key distribution introduced indicates quantum keys distributed tags reader information server via weakly coherent transmitted optical fiber work mainly presents protocol description detailed theoretical analyses including systems initialization transmission reception acquisition random quantum key authentication process information server tag reader security analysis protocol finally carried proves proposed protocol prevent various attacks solid security
objectivethe goal study compare novel wireless phone web based technology record store overactive bladder symptoms oab traditional paper chart bladder symptoms recorded period days using electronic chart standard paper chart twenty nine men lower urinary tract symptoms luts included study dropout rate patients preference correlation quality life measures qol symptoms recorded versus assessed compared total number patients enrolled study completed full day trial using using preferred preferred participants using patients record least one episode urgency versus using record least one using versus using statistically significant correlation found lower severity oab higher qol using recording methods study population recording symptoms prove preferable compared however provided level accuracy better adherence study protocol
postpartum depression growing mental health concern new mothers fathers purpose study determine predictors depression months postpartum comparing depressed couples couples one depressed partner depressed partner using data pregnancy outcomes nutrition study data mothers fathers collected second trimester months postpartum results showed predictors mothers low household income high prenatal depressive symptoms low social support higher number stressful life events fathers similar predictors including low household income high prenatal depressive symptoms low social support smoking compared non depressed couples factors predicted mothers fathers couples included low income high prenatal depressive symptoms mothers low prenatal social support reported fathers
modern experimental generate prolonged intense data streams example non contact measurement techniques particle image velocimetry based continuous image processing widely used experimental hydrodynamics experimental stereo volumetric velocimetry able generate long lasting intensive flows images using two cameras high computational complexity image processing algorithms main limiting factor conditions low computational performance removal limitations moving image processing tasks remote using proposed technology distributed allow users apply new high precision parallel algorithms real time implement feedback experimental setup paper describes innovative technology high performance processing intensive flows structured data generated experimental setup delivered high speed backbone directly computing nodes remote high bandwidth delay product problem case design protocols tcp respect performance tuning achieve maximum network throughput solved designed middleware elsevier inc rights reserved
background assess relationship hours sunlight railway suicide attempts days attempts methods railway suicide attempts causing railway suspensions delays min used linear probability model assess relationship study conducted japan data collected railway delay incident database japanese railway technical research institute public weather database japan meteorological agency results railway attempts occurred less sunlight days leading railway suicide attempts associated higher proportion attempts sunlight days attempt similar trend difference found sunlight hours median iqr without median iqr railway suicide attempts evening finally apparent correlation railway suicide attempts monthly average sunlight hours attempted month month limitations railway main suicidal methods japan conclusions observed increased proportion railway suicide attempts several days without sunlight light exposure blue light bright white light trains useful reducing railway especially consecutive days without elsevier rights reserved
simultaneously using different types distributed computing infrastructures like grids clouds increasingly common situation infrastructures characterized different attributes price performance trust task scheduling problem becomes complex challenging paper present design fault tolerant trust aware allows execute bag tasks applications elastic hybrid following user defined scheduling strategies approach named combines pull based multi criteria decision making algorithm multi criteria scheduling leads multiplication possible scheduling strategies propose soft methodology allows find optimal scheduling strategies given set application requirements validation method performed simulator fully implements hybrid environment including internet desktop grid cloud best effort grid based real failure traces set experiments shows able maximize user satisfaction expressed accordingly three distinct criteria price expected completion time trust maximizing infrastructure useful employment resources owner point view finally present optimization bounds computation time algorithm making realistic possible integration wide range resource management software elsevier rights reserved
second part article reports query essential characteristics effective engineering networks current business environments case studies focusing engineering design manufacturing engineering engineering services engineering networks four global leading companies studied refine enrich extend preliminary understandings gained first part article case studies suggested essential characteristics effective engineering networks four main areas including efficient engineering processes effective engineering learning flexible engineering resources digital engineering environment contributes theoretical understanding international engineering operations bridging missing link engineering network theories unique nature engineering expected findings help managers improve performance engineering networks facilitate effective interface management engineering functional areas
thyrotropin receptor gene defined highly gene mutations gene result either gain loss receptor function subclinical hypothyroidism clinical condition defined elevated serum tsh level associated normal free thyroxine free triiodothyronine chronic autoimmune thyroiditis frequent cause subclinical hypothyroidism adults rare cases loss function mutation cause present study novel mutation confirmed loss function mutation identified year old chinese woman potential cause patients subclinical hypothyroidism case provide valuable insight etiology
present research paper deals theoretical study numerical simulation control strategy wind energy conversion system based doubly fed induction generator stator directly connected grid rotor connected electrical network back back converter filter rotor side converter controls power flow stator grid controlling rotor currents grid side converter ensures regulation voltage desired value regulates power flow rotor grid controlling filter currents standard current controllers used regulate output currents simulation results presented show effectiveness proposed control technique wind fluctuation
limited efficacy immune checkpoint inhibitors hepatocellular carcinoma hcc observed clinical trials thus prompting investigation combination therapy interleukin important roles modeling immune responses cancers hypothesized blockade enhance antitumor immunity hcc anti programmed death ligand checkpoint inhibitor treating hcc sources immune modulating effects investigated hcc models combination anti anti tested hcc bearing mice found mainly secreted cancer associated fibroblast tumor cells hcc high expression induce strong immunosuppression hcc microenvironment immunosuppressive cells myeloid derived suppressive cells addition high expression also impaired tumor infiltrating cell function via inhibitory immune using blockade reverse anti resistance hcc tumor model conclusion study indicates targeted inhibition enhance efficacy anti hcc providing potential strategy overcoming anti resistance hcc published elsevier inc
determine degree observed benefit accounted psychosocial mechanisms derived quit smoking messaging versus use extra smoking cessation treatments services multiple mediation model randomized controlled trial rct states nation wide total adult daily smokers participated participants average age predominantly female white lacked college degree medium nicotine dependence average nicotine dependence score score half made previous quit attempt daily smokers web smoking cessation support recruited july randomized receive smoking cessation support via versus smoking cessation material changes psychosocial constructs health behavior change use extra treatment assessed month using single item measures outcome self reported day point prevalence abstinence month follow accounted effect smoking cessation psychosocial mechanisms complete paths increases self efficacy quitting know sense someone partially explaining conferred benefit use outside resources including treatments promoted explicitly medication treatments resources promoted online self help materials complete paths interaction effect existed medication use suggested participants using medication conferred substantial benefit participants using medication messaging programs smoking cessation appear primarily confer benefit promoting improvements psychosocial processes related quitting rather use extra smoking cessation treatments services
interaction cells natural environment influences large variety cellular phenomena including cell adhesion proliferation migration complex extracellular matrix network challenged attempts replicate vitro heterogeneity cell environment threatened general relevance vitro studies work describe new extremely versatile approach generate native like extracellular matrices controlled morphologies vitro study cellular processes general approach combines culture fibroblasts guiding templates direct three dimensional growth defined extracellular networks structural complexity features typically found vivo evaluate performance studied fundamental cellular processes including cell cytoskeleton organization cell matrix adhesion proliferation cases found striking differences depending matrix architecture particular compared standard two dimensional environments also assessed whether engineered matrix networks influenced cell migration dynamics locomotion strategy finding enhanced migration efficiency cells aligned matrices altogether methodology way development high performance models extracellular matrix potential applications tissue engineering diagnosis stem cell biology
background studies shown stress implicated cause neck pain objectives purpose study examine effect simple zero cost stress management program patients suffering methods study parallel type randomized clinical study people suffering chronic non specific chosen randomly participate eight week duration program stress management including breathing progressive muscle relaxation intervention control condition self report measures used evaluation various variables beginning end eight week monitoring period descriptive statistic methods used statistical analysis results end monitoring period intervention group showed statistically significant reduction stress anxiety report stress related symptoms percentage disability due intensity time daily routine satisfaction levels elevated statistically significant difference observed cortisol measurements conclusions stress management positive effects patients
objective study develop conceptual model analyze role rice fields water management use model suggest appropriate land development rice fields traditionally seen east south east asia particularly areas considerable seasonal variation rainfall resulting flooding drought one advantages fields east asia period rainfall similar period water demand rice study water management functions rice evaluated using rainfall storage discharge modeling system type structure used rainwater management study area rice assumed rice considered perform storage catchment functions rainwater harvesting system system used analyzing outflow rate according rice area peak outflow curves year period effectiveness system reducing final water discharge rate rice evaluated
introduction neurological complications quite frequent patients solid organ transplantation presenting focal generalized neurologic symptoms altered mental status posterior reversible syndrome rare entity characterized headache altered mental status cortical seizures focal neurological signs diagnostic magnetic resonance imaging case report present case year old woman one episode seizures sudden onset altered mental status time person perception accompanied headache postoperative day renal transplantation conclusion posterior reversible syndrome although uncommon post renal transplantation complication considered patients several factors surrounding setting transplantation implicated development thus physicians aware condition order establish diagnosis offer appropriate treatment
colorectal cancer second common cause cancer related death due migration tumor cells distant sites metastasis accumulating data indicate play important role several aspects colon cancer cell biology herein examined role mir colon cancer cell migration induced axis colon cancer cells found mir knockdown serum colon cancer cells decreased induced cell moreover mir markedly decreased activation colon cancer cells bioinformatics analysis predicted two putative binding sites rich element utr mrna mir binding mrna verified using target site blocker functionally validated rna immunoprecipitation assays showing mir dependent regulation mrna mediated rich elements present utr region taken together results show mir positively regulates mrna levels translation cell migration serum colon cancer cells indicate targeting mir useful strategy colon cancer metastasis
introduction sharing overview presentations given part skin academy held spain april skin academy international interdisciplinary dermatology initiative created contribute growth scientific knowledge dealing skin diseases years meeting aimed build bridges latest research everyday clinical practice providing dermatologists important updates common skin diseases current hot topics
background several risk factors associated multiple sclerosis progression amenable intervention objective systematically review evidence interventions targeting risk factors progression methods searched six databases existing reviews till march consulted experts identify randomized controlled trials rcts interventions targeting risk factors results total rcts met inclusion criteria expanded disability status scale scores exercise interventions differ compared untreated controls standardized mean differences confidence interval seven rcts low quality evidence dietary interventions show statistically significant effect relative risk progression four rcts moderate compared placebo scores vitamin supplementation significantly different placebo five rcts low conclusion identify risk factor interventions significant effects progression overall limited adequately powered trials needed vitamin supplementation long term exercise smoking cessation
quantitative interpretation large scale controlled source electromagnetic data frequency domain requires efficient stable three dimensional forward modeling inversion codes paper present forward modeling scheme frequency domain surveys based finite volume method solves equation total electric field important step modeling scheme solve large linear equation system resulting discretization order obtain stable accurate numerical solutions linear equation system solved direct matrix solver namely robust commonly used iterative solvers subspace iterative techniques numerically difficult cases algorithm suitable multi source modeling separating solving process single expensive matrix factorization relatively inexpensive forward backward substitutions many right hand sides total field formulation dense vicinity source points usually required mitigate source extra cells boundaries needed meet boundary conditions quickly increase size linear equation system solved making computationally expensive direct solutions avoid substantial increase size discretized model source correction technique applied reduce source boundary effects addition considering independence computation different frequencies parallel forward modeling scheme based frequency partition implemented speed simulation multi frequency problems numerical experiments carried evaluate performance forward modeling algorithm numerical solutions using algorithm show good agreement quasi analytic solutions layered models numerical errors significantly reduced source correction vicinity source points addition comparison simulated data generated algorithm published data typical marine model algorithm besides statistical results demonstrate parallel computing based simple frequency partition approach achieve nearly linear speedup due independence computation frequencies multi frequency simulation
detecting different categories objects image video content one fundamental tasks computer vision research detection hot research topic several applications including robotics surveillance automotive safety address problem detecting surveillance videos paper present new feature extraction method based multi scale center symmetric local binary pattern operator modules segmentation feature training occlusion handling proposed method introduced details design implementation experiments sequences show presented system detect real time effectively accurately surveillance videos
urban water pollution becomes increasingly serious sewage treatment process becomes much complicated highly complex sewage treatment projects challenge traditional design construction management mode based parameterization visualization simulation collaboration characteristics bim technology paper used core bim building sewage treatment structure models explore suitable way modeling based building information model imported schedule information form model carrying construction simulation model studied application bim technology construction management sewage treatment project
deep learning causing complete drift shallow architecture deep architecture estimate shows computers learning rather processing deep learning fast growing effects area pattern recognition computer vision speech recognition feature extraction language processing bioinformatics statistical classification make system learn deep learning makes use wide horizon machine learning algorithms gene expression data uncertain paper discuss supervised unsupervised algorithms applied gene expression dataset intermediate algorithms classified semi supervised self taught also play important role improve prediction accuracy diagnosis cancer discuss deep learning algorithms provide better analysis hidden patterns dataset thus improving prediction accuracy
oxytocin reduces amygdala responses threatening social stimuli males suggested facilitate approach related processing either decreasing anxiety salience current administration study tested whether oxytocin either reduces enhances amygdala responses threat approach placebo controlled randomized double blind subjects design healthy males undergoing fmri social approach avoidance task oxytocin decreased amygdala activation threat approach threat avoidance neural effect supports social effects provides neuroendocrine mechanism promoting social approach findings yield clinical implications individuals suffering social approach patients anxiety disorders elsevier ltd rights reserved
paper present new parallel software package symmetric sparse matrix ordering shared memory systems complete fill minimization problem solved means multilevel nested dissection algorithm modifications vertex parallel processing done task based fashion granularity tuning employ techniques shared memory using technology opposed message passing interface based approach widely used parallel sparse matrix ordering experimental results symmetric matrices university florida sparse matrix collection matrices finite element analysis three dimensional strength problems show implementation competitive libraries ordering quality performance library publicly available state university center web site
verification interesting challenging problem human face analysis received increasing interests computer vision recent years paper presents neighborhood correlation metric learning method verification via facial image analysis existing metric learning based verification methods developed similarity metric powerful enough measure similarity face samples especially captured wild conditions motivated fact correlation similarity metric better handle face variations similarity metric propose method using correlation similarity measure relation facial images better highlighted since negative samples usually less positive samples automatically identify discriminative negative samples training set learn distance metric discriminative encoded negative samples better exploited experimental results show efficacy proposed approach elsevier rights reserved
purpose identify correlates parent communication abortion among adolescents methods african american females aged years attending one three schools south side recruited surveyed regarding parental relationship quality attitudes toward sexual health communication sexual health calculated odds ratios ors ever discussing abortion using multivariable logistic regression results adolescents ever discussed abortion parent parent abortion plan parent physically ever communicating abortion significantly associated mother teen pregnancy confidence interval abortion attitude discussed sexually transmitted infections birth control parent perceived parental approval adolescent sexual activity ever communicating abortion inversely related sexually experienced supportive parental reactions abortion decision conclusions although almost half sample sexually active majority never parents abortion reported harm situation arise public policy focus promoting parent communication unwanted pregnancy rather forcing communication occurs society adolescent health medicine rights reserved
transgender people often face prejudice discrimination school employment housing health care affect psychological although literature prejudice toward transgender people growing limited research examined differences attitudes toward trans women trans men separately specifically current study examined role physical appearance acceptance transgender women men gendered spaces including rooms residence organizations participants viewed masculine appearing feminine appearing images measurements overall gendered space acceptance assessed results indicated general trans women less accepted trans men less accepted gendered spaces compared feminine appearing trans woman images trans men also female participants generally accepting transgender people participants findings suggest compared trans men discrimination trans women likely especially trans womans physical appearance traditional gender expectations
study used data life histories non women examine extent women exposed multiple forms victimization including child abuse intimate partner violence sexual assault traumatic life events assessed effects multiple womens outcomes attempted suicide drug alcohol problems whether prevalence rates effects victimization significantly different women results indicate women experience significantly victimization non women associated higher likelihood alcohol problems drug problems attempted suicide among non women marginally associated increased likelihood alcohol problems among women finally low levels affected alcohol drug problems among non women differently
smart people detection systems nowadays using heterogeneous cameras paper proposes architecture focused robustly detecting people infrared visible video fusion smart environment architecture covers levels provided int framework initially designed perform monitoring activity interpretation tasks indeed int used development environment approach starts image segmentation infrared visible spectra results fused enhance overall detection performance paper describes detail int levels selected implement new architecture acquisition segmentation fusion identification tracking levels
one important goal developing country establish provide electric power citizens initiated government many years ago renewable energy key component development already made significant reaching population urban rural areas renewable energy projects initiated government helping private sector non organizations micro institutions expand solar energy program terms sustainability commercial viability projects increasing awareness among consumers benefits correct use solar home systems study therefore investigates whether solar business industry implement common strategy position country authors outline benefits using solar energy possibilities regarding solar energy system problems relating sector data collected via questionnaire systematic random basis results indicate significant business potentials solar energy sector perception towards renewable energy product measured terms convenience country made perception whole enhance comfort society extent also contribute economy proper sales service given consumers authors recommend initiation motivational awareness policy developers achievement sustainable growth production renewable energy
background coronary computed tomography angiography allows evaluation coronary plaque volume low attenuation lipid rich component plaque vulnerability assessment purpose determine effect iterative reconstruction coronary plaque volume composition material methods consecutive patients without coronary artery disease prospectively enrolled slice images reconstructed filtered back projection hybrid algorithm levels coronary plaques assessed according predefined unit attenuation intervals total plaque interval volumes results fifty three patients mean age years included noise significantly decreased signal noise ratio snr contrast noise significantly improved levels comparison plaque characterization performed patients total plaques total plaque volume ranged low attenuation plaque component statistically significant differences levels respectively conclusion improved image quality total low attenuation plaque volumes similar using either
beta gene encoding dehydrogenase escherichia coli coli transformed wheat via agrobacterium mediated transformation pcr amplification southern blotting confirmed existence transgene transformed plants progeny levels expression beta gene varied among different transgenic lines based pcr analysis salt stress conditions transgenic lines higher levels glycine chlorophyll lower ratios solute potential less cell membrane damage lines also retained moderately higher photosynthesis rates vigorous growth wild type line nacl field trial high salt field transgenic lines higher rates higher grain yields comparison wild type plants suggested transgenic plants tolerant salt stress potential breeding salt tolerant wheat
extent core periphery hierarchical trade patterns significantly changed emergence asia remains debated paper addresses debate examining spatial patterns mobility asian countries global solar energy trade based network analysis shows japan singapore malaysia emerged core countries early asian core expanded six countries including japan south korea china singapore china particular moved upward spatial hierarchy united states also experienced considerable vertical mobility germany stable core rise east southeast asia however decrease economic inequality internationally rather new patterns network inequality observed within asia globally less developed southeast south marginal mobility
social interactions play important role overall current practice monitoring social interactions questionnaires surveys inadequate due recall bias memory dependence high end user effort however sensing capabilities smart phones play significant role automatic detection social interactions paper describe method detecting interactions people specifically focusing interactions occur walking walking together subjects important aspect social activity thus used provide better insight social interaction patterns work rely sampling smartphone accelerometer sensors analyse accelerometer data separately combine detect walking results show seven days monitoring using seven subjects real life setting achieve accuracy precision recall detection rates combining modalities
narrative first hypothesis argues famous child abuse cases really response definition narrow based scholarly literature propose criteria identifying rate four known child abuse cases criteria show classic second hypothesis argues child abuse cases probably response point many instances important facts ignored relevant scientific information running contrary hypotheses conclude often inaccurate tends make strong without integrating relevant scholarly scientific information scholars approach book caution
amyloid beta precursor protein app normally cleaved alpha also cleaved produce fragments endoplasmic reticulum membrane subsequently cleaved amyloid beta beta aggregation known cause alzheimers disease therefore removing preventing disease membrane protein participating endoplasmic reticulum associated degradation one stages resolving stress proteins accumulated postulated one processes degrade however remains unclear degradation depends study investigated effect degradation observed membrane fraction mouse neuroblastoma cells level increased stress level decreased however despite induction stress change amount knock cells interaction essential component complex occur knock cells decreased knock cells also found extracellular amount beta relatively higher knock cells control cells results suggest required degradation resulting inhibition beta production elsevier inc rights reserved
study examined parent offspring communication related information effects childrens feelings fear towards animal mothers instructed provide information novel animal children studying either neutral attributes characteristic animal first mothers instructed nonverbal way also allowed use verbal results indicated nonverbal communication mothers failed produce effects subjective evaluations animal however verbal information transmission differential impact childrens feelings fear children mothers communicated set specimens displayed higher levels cohens also exhibited higher levels fear cohens towards novel animal compared children mothers communicated neutral specimens effect fear mainly due fact children verbal neutral information exhibited clear decline fear whereas children mothers provided verbal information maintained similar level fear towards animal implications results familial transmission fear discussed
goal study find moderating role type industry different levels management respect perception advantages use stress management study tried find relationship perceptions advantages perception using corporate training specifically stress management cross sectional survey conducted structured questionnaire collect data managers working different levels including manufacturing sector services sector results study show positive relationship perception stress management relationship significantly stronger services industry positive relationship advantages stress management relationship significantly stronger manufacturing industry study also revealed positive relationship perception stress management relationship significantly stronger senior management middle management
mental health needs common among community corrections offenders many enrolled form supervised mandated treatment one category mental health problem treatment completion among supervised treatment diagnosis personality disorder systematic review reports sixteen studies comprised full mixed supervised samples community based treatment examines impact treatment completion studies difficult compare differences program setting definition treatment completion definition method assessment type treatment among variables impact antisocial personality disorder treatment common focus rarely assessed relevance dsm categories management community corrections limitations current diagnostic categories discussed
individuals bipolar disorder high rates medical illness premature mortality analysis correlates poor adherence medication patients medical comorbidities majority female african american mean age years mean duration years mean years education mean proportion days missed doses past week sex age education race living alone correlate adherence medications severe psychiatric symptoms correlated worse adherence specifically poor adherence correlated retardation factors depression rating scale affect factor brief psychiatric rating scale among poorly patients medical comorbidities number medications tension anxiety somatic symptoms depression related worse medication adherence
frequent manifestation pancreatic cancer limit patients ability take chemotherapy associated shortened survival developed model predict early onset advanced pancreatic cancer patients patients newly diagnosed untreated metastatic locally advanced pancreatic cancer included serum cytokines drawn prior therapy patient symptoms recorded using symptom inventory primary endpoint either weight loss death within days start therapy twenty seven patients met primary endpoint either lost body weight died within days start treatment univariate analysis smoking history symptoms pain difficulty high levels tnf low correlated endpoint used recursive partition fit regression tree model selecting four variables pain difficulty important predicting model two cytokines demonstrated better sensitivity specificity outcome respectively individual cytokine tumor marker frequent pancreatic cancer one three patients met endpoint weight loss death within days inflammatory cytokines better conventional tumor markers predicting outcome recursive partitioning analysis suggests model offer better ability individual cytokines predict outcome
coupled applications composed potentially large number tens thousands even tasks commonly used high throughput computing many task computing paradigms efficiently execute large scale computations exceed capability single type computing resources within expected time able effectively integrate resources heterogeneous distributed computing systems clusters grids clouds paper quantitatively analyze performance three different real scientific applications consisting many tasks top systems based partnership distributed computing clusters grids clouds understand application resource characteristics show practical issues normal scientific users face course leveraging systems experimental study shows performance coupled application significantly affected characteristics system along hardware specification node impacts performance vary widely depending resource usage pattern application devise preference based scheduling algorithm reflect characteristics resource usage patterns various coupled applications running top systems experimental study preference based scheduling algorithm allocate resources different systems coupled applications based preferences applications systems evaluate overall system performance various preference types using trace based simulations determined based different factors cpu specifications application simulation results demonstrate importance understanding application resource characteristics effective scheduling coupled applications systems
considering role prosocial behaviors oxytocin suggested diminish levels aggression nevertheless recent findings indicate oxytocin broader influence increasing salience social stimuli therefore certain circumstances increase antisocial behaviors aggression controversy led following indeed oxytocin promotes primarily prosocial behavior administration expected diminish levels aggression however oxytocin mainly acts increase salience social stimuli expected levels aggression following order test assumption used social orientation paradigm monetary game played partner allows measuring three types responses context aggressive response reducing point partner response adding point collaborative response adding half point partner half point current double blind placebo controlled within subject study design participants completed task following administration oxytocin placebo results indicated among subjects naive procedure oxytocin increased aggressive responses comparison placebo results support hypothesis oxytocin suggest oxytocin plays complex role modulation human behavior elsevier inc rights reserved
research focuses using analytical fluid mechanics determine whether patients reading trusted assess severity occurs valve inlet separating left left ventricle fully close ventricular allowing blood flow left ventricle left clinicians knowing severity flow important preventing eventual heart failure effect phenomenon particular patient believed cause discrepancies results leading clinicians sometimes diagnose patients severity propose generate tool reading solid geometries using judge prevalence wall effect fluid jet read using control volume analysis jet valve analytical solution expected flow profile based wall effects around jet derived using turbulent ansys model detailed velocity momentum mappings blood flowing valve left obtained believe first steps towards understanding wall effects determining level trustworthiness reading severity
small areas defined census environmental protection agency epa population population density least people per square phase national pollutant discharge elimination system storm water managers preserve compliance qualitative regulations often task given limited resources municipal authorities diffuse hydrologic impacts urbanization objective paper assist storm water managers providing geographic information system gis workflow supported python produces geographic database storm water infrastructure subsequently used create fully parameterized hydrologic hydraulic model guidance model provided suggestions measuring discharge storm systems application objectives demonstrated watershed unique municipal academic partnership development work finally improvements research ideas suggested storm water management small american society civil engineers
paper presents two within subjects studies exploring different combinations visual auditory feedback influence perceived virtual self perception experience safety virtual platform suspended first study frequency factor sounds altered visual appearance changed newly built bridge old bridge weaker structure broken second study sounds wood added sounds half compared without sounds moreover frequency factor frequency controls also manipulated visual appearance bridge limited model old broken bridge
seven kinds transgenic tobacco plants transformed combinations three genes obtained transgenic plants transformed genes appeared highest soluble sugar content strongest salt tolerance thought one important regulators involved plant tolerance various abiotic stresses study wheat derived genes fft encoding biosynthesis enzymes isolated cloned vectors modified seven different combinations three target genes transformed tobacco plants agrobacterium mediated approach transgenic tobacco plants identified pcr elisa southern blotting compared tobacco plants transformed six combinations three target genes wild type plants transgenic plants transformed genes contained highest soluble sugar content seven types transgenic tobacco plants displayed much higher level tolerance drought low temperature high salinity compared wild type differences drought low temperature tolerance transgenic plants containing single gene harboring two three genes significant salt tolerance level transgenic plants different gene combinations high low fft fft fft single gene results indicated transgenic tobacco plants various abiotic stresses associated transformed target gene combinations contents soluble sugar contained transgenic plants
photocatalytic water splitting generation clean hydrogen energy received increasingly attention field study successfully fabricated via simple one step heating strategy photocatalytic activity prepared photocatalysts evaluated water splitting hydrogen evolution visible light irradiation lambda compared obtained exhibited remarkably improved hydrogen production performance found presented best photo catalytic hydrogen evolution efficiency times higher pure moreover sample also displayed excellent stability even photocatalytic test experimental study enhanced photo catalytic activity mainly attributed significantly improve interfacial charge separation work provides facile approach design based photocatalyst develops efficient visible light driven application solar energy conversion published elsevier ltd behalf hydrogen energy publications llc
background objectives behaviour therapy trains participants use behavioural skills managing emotions study aimed evaluate whether skills use associated positive treatment outcomes independently treatment processes common across different therapeutic models method use skills three common treatment processes therapeutic alliance treatment credibility self efficacy assessed every months year individuals borderline personality disorder receiving mixed multilevel modelling used determine association factors frequency self harm treatment dropout results participants used skills less often likely drop subsequent two months independently self efficacy therapeutic alliance perceived treatment credibility frequent use skills higher self efficacy independently associated less frequent concurrent self harm treatment credibility alliance independently associated self harm treatment dropout limitations skills use measure applied control group receive sample size insufficient structural equation modelling conclusion skills building increased sense self efficacy important partially independent treatment processes behaviour therapy however direction association variables self harm requires evaluation elsevier ltd rights reserved
distribution discovered context particle measurement found distribution little later investigating strength materials years finally showed distribution potential wide applications statistics however justify name used important probability distribution neutral technical name like powered exponential distribution suitable paper discusses papers work
polarized epithelial cells sort newly synthesized recycling plasma membrane proteins distinct trafficking pathways directed either apical membrane domains trans network established site protein sorting increasing evidence indicates key role initial trafficking newly synthesized proteins apical proteins shown route plasma membrane particular apical proteins traffic either early recycling use tag system analyze trafficking apical protein also known show newly synthesized apical recycling apical early contrast post delivered recycling back apical membrane pathways pursued newly synthesized recycling populations demonstrating biosynthetic post pools protein subjected distinct sorting processes
long noncoding rnas transcripts low protein coding potential large part transcriptional output roles include regulating gene expression epigenetic transcriptional post transcriptional level cellular homeostasis however studies still infancy functions vast majority transcripts remain unknown generally known function human nervous system largely relies precise regulation gene expression various studies shown significant impact normal neural development development progression neurodegenerative diseases review focused recent studies associated neurodegenerative diseases including alzheimers disease parkinsons disease disease amyotrophic lateral sclerosis als multiple system atrophy frontotemporal degeneration caused unexplained ganglion cell lesion apoptosis now labeled chronic neurodegenerative disorder therefore discussed association illustrate role specific provide new insights understanding etiology pathophysiology neurodegenerative diseases mentioned
many small rnas cloned animal example endogenous small interfering rnas found interacting rnas found testis chicken important model organism small rnas identified study isolated cloned small rnas adult chicken testes since reasonably even distribution small rnas slightly longer mirnas genome mapping indicated small rnas derived regions exons repetitive elements including chicken repeat long terminal repeats simple repeats since similar named like rnas rnas northern blotting selected sequences showed nine specifically expressed adult testis vast majority rnas poorly conserved species suggesting unique adult chicken testis analysis cloned rnas improve understanding function small rnas animal development
manufacturing engineering important task assess manufactured part design specification task usually carried measuring manufactured part using coordinate measuring machine provide set coordinate data software used fit design surface data data fitted surface examined determine manufactured part within tolerance result process strongly depends correctness software used fitting validate software one often uses pre generated reference datasets reference dataset associated reference solution compared solution returned software test referred test solution real world applications datasets represented stored using finite numbers using finite precision software test processes dataset test solution generally differs reference solution paper present method determining numerical uncertainty reference solution used comparison test solution reference solution results applying method fitting data geometric elements presented
inquiry frequently used alteration mechanisms investigate local government reforms application leadership identity framework examines judgments commission make course inquiry article explores roles commission play authorities judgments commission make scope stakeholder engagement whether adjust agenda inquiry generate four types leadership identity advocate catalyst leadership identity framework applied two conducting proposed structural reform local government two systems northern ireland new south application framework reveals commission process leads shift leadership identity systems despite different distinctive historical social political contexts
objectives suboptimal sleep duration considered increase risk stroke incidence thus aimed conduct dose response meta analysis examine association sleep duration stroke incidence methods searched pubmed web science cochrane library identify prospective studies evaluating association sleep duration fatal stroke incidence restricted cubic spline functions piecewise linear functions used evaluate nonlinear linear dose response association results included total prospective studies participants stroke events nonlinear dose response meta analysis showed shaped association sleep duration total stroke lowest risk observed sleeping considering people sleeping reference long higher predicted risk total stroke short pooled risk ratios confidence intervals short sleep durations significantly associated stroke total stroke subgroups structured interview non asian countries additionally found slightly decreased risk ischemic stroke among short piecewise linear trends compared every increment sleep duration led increase pooled risk ratios confidence intervals risk total stroke conclusion nonlinear piecewise linear dose response meta analyses long sleep duration significantly increased risk stroke incidence elsevier rights reserved
biologic drugs infliximab anti tumor necrosis factor monoclonal antibodies transformed treatment immune mediated inflammatory conditions crohns disease ulcerative colitis collectively known inflammatory bowel disease ibd however complex manufacturing processes involved producing drugs mean use clinical practice expensive recent several biologics led development versions drugs aim providing substantial cost savings increased accessibility treatment undergo regulatory process involves proving structural functional biological reference product also expected clinical demonstrated clinical trial one sensitive population requirements fulfilled extrapolation approval indications approved permitted without need clinical trials long scientifically however justification requires mechanism action question similar across indications also comparable clinically tested population likewise pharmacokinetics immunogenicity safety similar across indications comparable clinically tested population date anti tumor necrosis factor tested trials patients rheumatoid arthritis concerns raised regarding extrapolation clinical data obtained populations ibd indications review discuss issues surrounding indication extrapolation focus extrapolation ibd
cryptographic algorithms secret keys generated randomly security system depends key therefore generation random sequences vital randomness testing done means statistical randomness tests work show probabilities overlapping template matching test test suite valid specific template need templates calculate exact distribution bit templates propose new randomness tests namely template matching tests new tests applied sequence minimum length whereas overlapping template matching test test suite applied sequences minimum length moreover apply proposed tests biased data observe new tests detect behavior generator even bias whereas template matching tests detect bias
nowadays open information system model widely adopted hospitals manage data related doctors patients however storage systems hospitals typically based old relational database management systems makes hard management patients data especially health level format fact data continuously order stored relational databases sent hospital systems considering also scenarios data continuously grow management patients information become hard paper discuss system able manage big data particular considering case study glucose observations format demonstrate scalable scenario storage big data processing convenient hospitals traditional storage systems
background traditionally squamous cell carcinoma scc lung central rather peripheral form lung cancer rates scc lung periphery typically range recently observed significant portion newly diagnosed scc located periphery comprehensive review tumor data facility teaching hospital large cohort cancer patients undertaken assess whether change traditional epidemiologic distributions lung cancer specifically respect scc given differences cell biology carcinogenesis central versus peripheral scc potential epidemiologic shift suggest change tumor biology methods confirmed diagnoses scc lung retrospectively reviewed patients lesion classified peripheral central based evidence results total patients diagnosed scc peripheral central scc twenty nine patients prior history malignancy subset patients peripheral scc central scc conclusion findings appear correlate initial observation within institution shift traditional distribution scc majority cancers now diagnosed lung periphery opposed central locations
trends higher education indicate women advanced degrees men male students female concentrated programs experience barriers academic success study investigated male graduate students experience female concentrated university four focus groups participants conducted mid atlantic university united states data analyzed using grounded theory methodology participants identified wide range masculinity norms focused academic tied fulfilling traditional gender roles worker provider traditional gender norms pursuit status achievement oriented participants experienced academic support faculty peers tied sense connection specific academic program perceived academic support connection contributed desire stay university complete degree practical considerations close high cost transferring also reported factors retention current research suggests aspects traditional masculinity high academic motivation linked male graduate students suggestions future research potential implications male students female concentrated university considered
purpose purpose paper explore robustness emerging body knowledge collaborative supply chains context engineered order manufacturing engineering project systems design methodology approach paper uses evolutionary classification technique build evolutionary history industry case study french machine design industry findings evolutionary history shows collaborative forms governance used industry era failed market based governance industry however collaborative forms governance return historical roots towards vertical integration research limitations implications findings relevant context investigated industry practical implications certain industrial settings managers consider promise collaboration trust originality value data set supports rejection trust mode governance calls careful conditions trust managerial situations
laminar radial flow two parallel fundamental nonlinear fluid mechanics problem described navier stokes equation exact solution found even extensive references unclear radial flow remains laminar high reynolds numbers paper first presents exact velocity distribution solutions developed radial proving flows described brief elliptic sine squared functions different characteristics inflow stable velocity distribution forms outflow velocity distribution point inducing flow instability separation velocity distributions become classic parabolic law low reynolds numbers uniform similar turbulent velocity distributions high reynolds numbers furthermore pressure boundary shear stress follow inverse square law friction factor invariant results studying open channel flow nonlinear inertia importance american society civil engineers
biogas provide sustainable energy source wood fuels rural households sub saharan african however functioning biogas limited areas low water availability water required approximately day day pig providing day person household using volume capita consider potential domestic water recycling rainwater harvesting aquaculture supply water needed digestion different countries sub saharan africa domestic water recycling found important every country usually insufficient meet requirements households countries need collect additional water rainwater harvesting also important role iron roofs effective roofs collecting water however even iron roof size roof commonly found sub saharan africa small collect sufficient water requiring extra area person rainfall local market fish pond fed growing provide important source additional income hold water required areas rainfall low seasonal rainy season allowing pond covered dry period reduce evaporation losses exceed rainfall extra catchment area needed maintain water level pond equivalent approximately person household
canine caused parasite systemic disease present variable clinical signs clinicopathological abnormalities clinical manifestations range subclinical infection severe systemic disease categorized neglected tropical disease complex immune responses associated species makes therapeutic treatments vaccine development challenging dogs humans review summarize innate adaptive immune responses associated infection dogs discuss problems associated disease potential solutions future direction required research help control parasite
widely accepted reinforcement made polyethylene polypropylene susceptible creep soils hydraulic conductivity varies void ratio however unfortunately available sensitivity analysis time dependent behaviour taking either reinforcement viscosity time varying hydraulic conductivity consideration influence geosynthetic reinforcement viscosity decreasing hydraulic conductivity consolidation time dependent performance floating columns investigated using fully coupled model working height corresponding post consolidation polypropylene geotextile strain shown assumption constant hydraulic conductivity failure consider viscous behaviour geosynthetic reinforcement underestimate time dependent deformations including differential crest settlement horizontal movement effects factors including foundation soil reinforcement stiffness column stiffness column spacing column type floating fully penetrating construction rate time dependent behaviour column supported explored elsevier ltd rights reserved
background direct oral anticoagulants share many indications warfarin require less frequent follow monitoring limited data available prescribing appropriate laboratory monitoring real world clinical setting objective determine patients receiving care university florida health internal medicine clinics prescribed according food drug administration fda approved labeling secondary objectives determine percentage patients receiving appropriate baseline laboratory tests prior initiation frequency laboratory monitoring methods retrospective chart review evaluated patients enrolled health internal medicine practices within health system prescribed april april adherence fda approved dosing recommendations baseline laboratory tests compared previously published data study approved institutional review board results total patients met inclusion criteria ninety six patients prior data collection patients started data collection patients prescribed per fda approved labeling obtained complete blood count serum creatinine liver function tests prior initiation conclusions prescribing practices significantly better published data however patients prescribed according fda approved labeling less half patients started obtained recommended labs prior medication initiation
online vector quantization method successfully applied kernel adaptive filters linearly growing radial basis function network thereby generating family however existing based mean square error criterion actually good choice non gaussian signals paper new kernel adaptive filter called kernel maximum developed robust large outliers impulsive noises mean square convergence analysis conducted sufficient condition guaranteeing convergence therefore obtained filtering accuracy also proved higher representative kernel least mean square addition make full use information hidden input output spaces propose modified based bilateral gradient limit final network size fixed budget also developed simulation results cases gaussian non gaussian noises presented validate proposed elsevier inc rights reserved
paper studies use interface achieve communication ordinary personal computer design entire system aspects including circuit design protocol host computer programming design lower computer program driver program written using simple character signal transmission microcontroller computer done information transmitted successfully using protocol
aim evaluate prevalence depression using different measures patients schizophrenia study relationship depression schizophrenia cognitive insight clinical insight disability socio occupational functioning methods total patients schizophrenia evaluated depression cognitive insight socio occupational functioning results patients included study one fourth found depression per mini international neuropsychiatric interview mini prevalence depression assessed depression scale schizophrenia hamilton depression rating scale depressive subscale positive negative syndrome scale respectively among different scales highest concordance clinicians diagnosis sensitivity specificity positive predictive value negative predictive value also higher noted without depression per clinicians diagnosis compared depression found significantly higher scores positive negative syndrome scale positive general psychopathology subscales total score participation restriction assessed scale lower level functioning assessed global assessment functioning significant difference noted negative symptom subscale clinical insight assessed item disability assessed indian disability evaluation assessment scale ideas socio occupational functioning assessed social occupational functioning assessment scale terms cognitive insight depression significantly higher score subscales self reflective self certainty subscales mean composite index score conclusion results suggest one fourth patients schizophrenia depression compared highest concordance clinicians diagnosis depression presence depression related cognitive insight
oxygen play important role many photocatalytic reaction attracted enormous attention scientists engineers surface bulk oxygen different function photo reaction process herein three different nanoparticles possessing surface oxygen bulk single electron trapped oxygen fabricated dehydration reduction different precursors three kinds nanoparticles characterized systematically xrd tem raman xps esr vis techniques photocatalytic reduction results indicated bulk surface oxygen contributed enhancement light absorption surface facilitated separation photo generated charge carriers contrast bulk acted recombination center existence surface bulk oxygen exhibited synergistic effect improve efficiency adjusting ratio surface bulk oxygen analyzing positron lifetime relative intensity positron efficiency improved increase ratio surface oxygen bulk elsevier rights reserved
paper describes main features state art monte carlo solver radiation transport implemented within world class open source object oriented platform scientific simulations monte carlo code makes use efficient ray tracing algorithms arbitrary unstructured meshes described detail solver accuracy first verified analytical solutions available validated space entry flight experiment fire comparisons experiments reference numerical solutions provided flexible design physical models ray tracing parallelization strategy fully mesh decomposition inherited fluid simulator implementation made efficient program summary program title identifier program summary http program program library university ireland licensing provisions general public license version lines distributed program including test data etc distributed program including test data etc distribution format programming language computer large hpc distributed systems operating system mac linux code parallelized parallelized mpi ram depending problem size several classification external routines mpi boost nature problem radiative processes play fundamental role science engineering contexts including combustion atmospheric space entry experiments plasma facilities shock tubes arc problem interested computation radiative heat transfer arbitrarily complex geometries particular characterize thermal loads acting surface space vehicles solution method code implements flexible efficient monte carlo algorithm making use state art ray tracing techniques designed validated arbitrary unstructured meshes code organized collection dynamically linked libraries connected computational kernel open source platform monte carlo method parallelized mesh decomposition partitioned mesh associated data structures fluid dynamics equations solved unusual features radiation transfer code offers unique combination ray tracing algorithms suitable handling simulations arbitrary unstructured grids parallelization strategy scalable based domain decomposition overall object oriented design allows easy integration new models algorithms dynamically self registration techniques additional comments code part much larger set libraries fully available https include multiple numerical solvers physico chemical models processing algorithms interfaces third party scientific software distribution also includes state art fully implicit finite volume solver euler navier stokes systems used produce flow solution radiative transport algorithm described paper solver used final paper based core finite volume modules different physico chemical radiation models latter made available library since rely third party libraries mutation version version distributed due distribution file program therefore delivered directly requested instead file giving details program obtained sent running time depending size computational grid number processors used running time vary seconds hours days included version code using relatively small meshes run cpu cores user however totally free run cases different number cores less according convenience elsevier rights reserved
functional movement screen aimed assessing fundamental movements often used identify players injury risk purpose study determine whether used predict injuries aged years eighteen football teams recruited prospectively followed months players years performed start study period players exposure hours injuries recorded difference overall score injured players significant points mann whitney test players scoring mean found analyses potential risk factors suggest higher age lower body mass longer football career risk factors injuries findings study suggest suitability injury prediction limited
paper considers robust low rank matrix completion presence outliers objective recover low rank data matrix small number noisy observations exploit bilinear factorization formulation develop novel algorithm fully utilizing parallel computing resources main contributions providing two smooth loss functions promote robustness two types outliers namely dense outliers drawn distribution sparse like outliers small additive gaussian noise efficient algorithm convergence stationary solution based parallel update scheme numerical results show proposed algorithm obtains better solution faster convergence speed benchmark algorithms synthetic real data scenarios
seasonal affective disorder sad characterized recurrent depression occurring generally fall winter numerous pieces evidence indicate association sad decreased brain neurotransmitter serotonin system functioning tryptophan hydroxylase key rate limiting enzyme synthesis brain paper concentrates relationship activity mood disturbances association human gene expression risk affective disorder application tryptophan sad treatment animal models sad main conclusions review follows brain deficiency contributes mechanism underlying sad involved regulation kinds genetically defined affective disorders iii activation synthesis exogenous tryptophan alone combination light therapy effective sad treatment effect combined treatments several advantages compared light tryptophan therapy alone first effective treatment patients resistant light therapy secondly tryptophan treatment antidepressant effect light therapy
increasing interest simultaneously optimizing many objectives typically three objectives problems leads emergence various many objective algorithms evolutionary multi objective optimization field however contrast development algorithm design assess many objective algorithms received scant concern many performance indicators designed principle number objectives practice used many objective optimization paper explain difficulties popular performance indicators face propose performance comparison indicator assess pareto front approximations obtained many objective algorithms evaluates quality approximation sets aid reference set constructed points reference set divided many clusters proposed indicator estimates minimum moves solutions approximation sets weakly dominate clusters verified analytic comparison several indicators empirical test four groups pareto front approximations different numbers objectives problem characteristics
system typical multivariable uncertainty strong coupling nonlinear dynamics system two dimensional extension system many scholars home study nonlinear control system experimental platform usually fuzzy adaptive control method applied uncertain nonlinear systems practical engineering common multivariable nonlinear system control matrix irreversible lacked certain applicability process uncertain nonlinear system control gain matrix determinant equal zero namely control matrix irreversible ball control therefore design system stability supervision state variable changes hierarchical controller great significance paper controller divided two layers upper layer supervision optimization lower combined adaptive rule sliding mode theory advantages intelligent algorithm design controller
great attention paid nitrogen oxides particulate matter emitted compression ignition engines adoption methane dual diesel contribute reduction pollutants paper aims investigate combustion phenomena occurring methane air charge direct injection diesel fuel research activity performed production compression ignition engine three cylinder equipped common rail injection system order operate diesel methane dual fuel mode intake manifold engine modified set electronic port fuel suitable gaseous fuels different engine speeds loads tested engine condition small part total energy provided direct injected diesel fuel remaining methane thermodynamics analysis combustion process performed conventional measurement involving cylinder pressure acquisition based optical techniques carried combustion visualization high spatial distribution temporal evolution two colour method applied flame images evaluate temperature concentration method allows achieve better insight pollutant formation experimental results revealed combustion occurs lower temperature formation diesel operation thus leading lower nitrogen oxides particle emissions exhaust elsevier rights reserved
objectives assess desensitization parents repeated exposure violence sex movies methods national sample parents living least target child age groups years old viewed random sequence pairs short scenes either violent sexual content popular movies youth rated restricted age years without adult supervision rated parents indicated minimum age consider appropriate view film predictors included order presentation parent child characteristics parent movie viewing history results exposure successive clips progressed parents supported younger ages appropriate exposure starting age years confidence interval violence age years sex declining age years violence years sex parents also reported increasing willingness allow target child view movies exposures progressed desensitization observed across parent child characteristics violence toward human non human victims movie rating frequently watched movies readily violence conclusions parents become violence sex movies contribute increasing acceptance types content parents raters employed film industry
order improve antibacterial activity acidic medium poly ethylene glycol block poly acid graft synthesized free radical addition ring opening polymerization reactions poly ethylene glycol raw material drug loading capacity encapsulation efficiency loaded prepared via thin film hydration method respectively drug loaded showed dependent property particle size zeta potential range control drug vitro release demonstrate higher release rate vitro antibacterial experiment indicated activity loaded aureus superior free medium using substitute dependent fluorescence decrease property laser confocal fluorescence microscopy analysis confirmed cellular uptake improved due groups enhanced cellular uptake release drug caused activity enhancement acidic medium compared free drug drug delivery system potential application field bacterial infection treatment elsevier inc rights reserved
herein present case anaphylaxis multiple family members asian food allergies including anaphylaxis unfortunately common previous reports multiple family members suffering reaction eating addition family members required multiple doses eventually infusion improve blood pressures interventions including started emergency medical services line medical direction reaction required treatment extensively documented medical literature
farming automatic measuring classification open problem small farms work done manually within process achieving inaccurate measurements research present state art results length estimation within water flow using image processing purpose designed implemented evaluated novel measuring prototype allows fish swim throughout channel order measured classified taking advantage behaviour swimming water flow prototype provided vision component able detect measure online capturing processing downward view images fish passes camera fish detected system control point event measuring process measure approximate third order regression curve fish body estimate length experimental evaluation achieving mean absolute error estimating lengths encouraging result allows draw different future work based experimental findings elsevier rights reserved
fluorescence situ fish molecular cytogenetic technique regularly applied fixed paraffin embedded tissue sections variety cancers assess chromosomal aberrations however high quality fish requires optimal enzymatic digestion insufficient digestion noted signals evaluated fluorescence microscope consequence fish results unreliable experiment repeated solve problem developed new method real time evaluation enzymatic tissue digestion termination enzyme activity proper time facilitates successful experiments repeated first performed fish samples digested different times revealed distinct morphological changes within nucleus space detectable light microscopy observations suggested presence intact clear bare nuclei space serve indicator adequate digestion developed protocol assessment indicator based morphological features applied collection tissue samples partly breast cancer partly different types lymphoma prior fish fish success rate significantly higher conventional method successful cases morphological signs adequate digestion easily fish signals new method real time assessment digestion quality improved success rate fish addition simple rapid
point care tools needed sub saharan africa improve pediatric lymphoma diagnosis treatment evaluated plasma epstein barr virus dna pediatric biomarker prospectively enrolled children compared classical hodgkin lymphoma diagnoses pediatric patients received standardized chemotherapy supportive care dna measured baseline mid treatment treatment completion assessed children dna detected proportions higher versus similar versus detected median dna log copies log copies log copies higher levels versus trend toward higher levels versus dna declined treatment cohort overall increased several children clinical relapse twelve month overall survival cohort overall children baseline detected survival worse baseline dna log copies versus log copies also dna detectable mid treatment versus undetectable among children baseline dna detected significant risk factor death months multivariate analyses adjusted hazard ratio per log copies quantitative dna potential utility diagnosis prognosis response assessment pediatric new lymphoma frequent childhood cancer sub saharan africa although highly resource rich settings outcomes much worse region point care tools needed improve diagnosis treatment epstein barr virus ebv associated common endemic form disease first study systematically assess plasma ebv dna pediatric diagnosis prognosis response assessment sub saharan africa results show plasma ebv dna biomarker facilitate diagnosis risk stratified response guided therapy challenging population region
ability engineer cells express protein interest inducible manner stably long period valuable tool molecular biology also one holds promise regenerative medicine future proteins suggested involved tissue regeneration chapter describe vitro method stable inducible expression protein cell line chondrocytes primary culture involve use viral vector
friendly low cost intelligent platform designed meet needs elderly users purpose assist old people daily activities maintaining physical cognitive fitness maintaining connection close ones increasing safety autonomy self confidence mobility paper considers main scenarios emphasized interviews conducted caregivers med medicine designed monitoring vital parameters assessing situation person take medicine order improve condition scenarios focused problems related cognitive ageing vital sign monitoring activity analysis monitoring vital parameters using medical expertise observed behaviors physical activity consists recommendations performing additional exercise detects low level physical activity solution centered taking account individual illness level acceptance usability
sexual dysfunction common side effect antipsychotic medications partly caused dopamine elevation prolactin randomized study monthly dopamine receptor partial agonist showed subsequent superiority versus dopamine receptor antagonist quality life scale patients schizophrenia aged years sexual dysfunction sexual experience scale serum prolactin levels also assessed odds sexual dysfunction lower versus week adjusted odds ratio confidence interval men women patients aged years among patients shifting sexual dysfunction baseline none week trend toward greater improvement total score mean prolactin concentrations decreased increased men women six treated patients experienced prolactin related adverse events addition greater improvement patients lower risk sexual dysfunction prolactin elevation versus
aim study assess relationship socially prescribed spp aggressiveness according components physiological emotional anger motor physical verbal aggression cognitive hostility sample included children year primary school years child adolescent scale aggression questionnaire used assess respectively spp components aggressive behaviour anger hostility physical verbal aggression mean difference analysis showed students high levels spp scored significantly higher sub scales aggression questionnaire compared peers lower levels spp moderate effect sizes obtained cases except hostility magnitude differences small logistic regression analysis revealed dimensions aggression questionnaire predicted significantly positively high scores spp ranging results showed close relationship spp manifestations aggression european journal education psychology published elsevier espana slu open access article license
several years trend learning study spread levels education benefits trend studying using learning materials students connected internet therefore able trace quickly easily additional information given text explained adequately positive impact students development independence creativity cases possible student even educating course method disadvantages health problems frequent computer problems social skills communication etc despite method teaching certainly indispensable future certainly replace existing system partly even completely unfortunately implementation trend simple faces many obstacles levels education theoretical fields philosophy human sciences creation learning materials easier lecture notes taught form long texts written form lectures electronic form supplemented simple interactive elements used test students studies technical fields machine design automotive industry machining etc face problems course teaching combine theoretical information practical principles industrial practices merging theory practice creates big problem developing electronic interactive study materials identical feelings students gain real example therefore department machine design university west focused problem conducted research software tools used create educational materials sought online also colleagues universities industry paper describes tools processes including advantages disadvantages used colleagues also focusing problem
asphalt able modify mechanical behavior activated magnetic field effect magnetic field increase stiffness perform magnetic field removed material original elastic properties fact smart materials offer wide range interesting engineering applications one use incorporation structures required support cyclic loading asphalt activated minimize impact traffic loads based considerations paper studies mechanical performance asphalt cyclic loads similar occurring real service life purpose magneto used carry different multiple stress creep recovery tests different magnetic field strength results obtained show spite fact significant recovery capacity reduce cumulative permanent deformations produced due effect cyclic loads effect magnetic field elsevier ltd rights reserved
objectives purpose study investigate whether motivational climates differential impact adolescent psychological physiological stress responses salivary cortisol important investigate relationship psychological stress stress responsive hormones implicated variety biochemical processes deleterious mental physical health although youth consistently respond positively caring task involving physical activity settings involving climates remain prevalent youth sport contexts design middle school students separated gender randomly assigned either min instructional session method salivary cortisol measured four times study including one baseline min session start three response measures min psychological stress motivational responses also examined including anxiety affect enjoyment effort individual items utilized stress perceptions assess psychological responses results results revealed climate significant rise salivary cortisol greater self consciousness shame negative affect anxiety relative group adolescents group responded favorably greater effort enjoyment conclusions findings suggest motivational climate differentially impact adolescents stress responses climates eliciting physiological psychological stress responses youth contrast climates buffer performance related stressors accompany group achievement settings yield protective response elsevier ltd rights reserved
development neurons differentiate nasal migrate organ along terminal nerves numerous studies described influence different molecules migration neurons however role microenvironment cells remains poorly understood study used gfp transgenic mice detect glial cells early developmental stages using nasal cultures glial cells neurons clearly demonstrated vitro approach showed glial cells began explants neurons remained ahead migratory front stopped neurons association glial cells combined gene expression analysis gfp sorted cells enabled identified olfactory cells immunohistochemical analysis revealed presence multiple glial cell type markers showing several subpopulations surrounding neurons moreover expressed genes whose products involved migration neurons situ data confirmed majority neurons associated glial cells along nasal terminal nerves nasal junction early overall data demonstrate microenvironment neurons mouse development fact glial cell type neurons encodes molecules involved nasal migration suggests participates system wiley periodicals inc wiley periodicals inc
background previously described dna variant identifies genetic variants pcr targeted massively parallel sequencing datasets generated protocol permits stringent filtering sequencing chemistry induced errors requiring reported variants appear reads overlapping pairs certain thresholds occurrence developed tandem used successfully screen genetic mutations breast cancer predisposition gene applied data format therefore relies sequence reads mapped reference genome paper describe improvement called primer directed data format avoiding need computationally expensive mapping stage taking advantage location specific nature pcr targeted data results algorithm achieves stringent variant calling significant runtime performance improvement one indicative sequencing experiment fastest mode required fold less sequential computation time pipeline fold less sequential computation time variant calling pipeline based popular tool implemented python runs popular like operating systems linux requires input format file containing primer sequence information format file containing reference genome sequence paired files containing sequence reads primer sequences end reads associate read pairs targeted thus expected corresponding coordinates reference genome primer sequence read compared reference sequence location variants identified using algorithm specifically variant called appear location overlapping reads user defined thresholds minimum number reads proportion reads conclusions provides rapid accurate genetic variant calling greatly reduced computational costs
bacterial community structure diversity assessed scale rotating procedure pilot plant salmonella community particularly monitored effects ultraviolet bacterial community studied identification dominant bacteria revealed presence beneficial useful species play important role process wastewater purification several species known activities revealed majority biofilm samples common detection salmonella community provides evidence system seriously affect salmonella furthermore investigation inactivation whole bacterial community secondary treated wastewater showed variable resistance results salmonella detection registered dose around since total salmonella recorded
background cutaneous adverse events important negative influence quality life compliance affected patients hand foot syndrome cutaneous toxicity associated treatment necessitates treatment interruption dose reduction severe cases case report doxorubicin induced shows influence mechanical stress development skin lesions various locations importance patient education compliance case report present case year old female patient diagnosed ovarian cancer undergone surgical treatment development extensive grade affecting numerous areas body particularly exposed mechanical pressure dermatological treatment combination local application antioxidant containing patients compliance made possible continue chemotherapy without interruption dose reduction conclusion development often limits use agents case report provide possible therapeutic preventive strategy affected patients
pathway plants responsible biosynthesis huge amount secondary metabolites derived tyrosine flavonoids synthesized end diverse metabolic pathway many intermediate molecules whose precise biological functions remain largely unknown diversity molecules increased action leading production related esters glycosylation change solubility stability toxic potential influencing biological activity glycosylation therefore represents extremely important regulation point homeostasis article review recent knowledge enzymes involved regulating glycosylation status availability different subcellular compartments also examine potential link glycosylation expression biosynthesis genes phenolic glycosylation genes different biological roles linked particular chemical properties often correlated plants stress management strategies also regulated glycosylation instance influence resistance plants infection microorganisms involved mechanisms related environmental changes impact flavonoid glycosylation color leaves seeds fruits also discussed altogether paper underlies fact glycosylation powerful mechanisms allowing plants regulate availability biological activity
syndrome common chromosomal disorder causing mental retardation worldwide average prevalence cases per births study aimed determine comorbidities associated coverage health care services developmental interventions southern thailand total infants recruited prospective birth defects registry system provinces southern thailand regularly followed every months data collection form included infants demographic data associated congenital anomalies developmental interventions infants born average gestational age weeks average birth weight length head circumference congenital heart diseases gastrointestinal defects congenital hypothyroidism found cases respectively percentage infants received developmental interventions current study significantly greater previous study covering years early stimulation program speech training program respectively infants study began intervention programs significantly earlier years years respectively congenital heart disease common comorbidity associated coverage health care services developmental interventions children generally improved southern thailand one hundred percent coverage health services interventions children special needs expected near future
light profound effects mood exemplified seasonal affective disorder sad beneficial effects bright light therapy however underlying neural pathways light regulates mood understood previous work developed diurnal grass rat animal model sad utilizing light dark paradigm simulates lower light intensity winter showed animals housed exhibited increased depression like behaviors forced swim test sweet solution preference compared animals housed bright light day objective present study test hypothesis light affects mood acting brain system diurnal grass rat model sad first immunoreactivity examined grass rats results revealed reduction number neurons hypothalamus attenuated fiber density dorsal nucleus animals compared group animals treated systemically selective receptor antagonist led depressive phenotype characterized increased immobility decrease compared vehicle treated controls results suggest attenuated signaling associated increased depression like behaviors grass rats support hypothesis system mediates effects light mood ibro published elsevier ltd rights reserved
distributed systems big data management often face problem load imbalance among nodes address issue exist almost many load balancing strategies different systems designing scalable distributed system towards handling large amounts information often easy anticipate kind strategy efficient maintain adequate performance regarding response time scalability reliability time based observation describe generic api implement experiment strategy independently rest code prior definitive choice instance show existing load balancing strategies used famous systems implemented api also present work helped implement load balancing distributed system modify behavior strategy lines code led easily perform various experiments determine efficient scheme system paper extension work presented workshop parallel distributed computing big data applications detail experiments extend use api broad class big data storage systems copyright john wiley sons ltd
new molecularly targeted therapeutics changing therapy janus kinase signal transducer activator transcription jak stat intracellular signaling pathway upon many different proinflammatory signaling pathways converge numerous inflammatory driven soluble inflammatory mediators rely jak stat signaling inhibition pathway using jak inhibitors useful therapeutic strategy diseases growing evidence suggests jak inhibitors efficacious atopic dermatitis psoriasis additional evidence suggests jak inhibition broadly useful dermatology early reports efficacy several conditions jak inhibitors administered orally used represent promising new class medications use jak inhibitors dermatology reviewed
real time simulation smoke sense reality difficulty research field computer graphics based improved particle system method carried real time simulation smoke stable role wind article improved method map smoke strong sense reality improve efficiency achieved requirements
research aims discovering traits abilities characterize ideal leaders employees iranian context employing strategy reach components ideal leadership middle managers employees possessing management knowledge context interviewed theme analysis global basic organizing themes extracted results showed whole themes categorized two groups prototypes anti prototype five themes prototypes labeled oriented employees emotionally mature decisive three anti prototype labeled narrow although components implicit leadership theories context produce distinct features research tried discover implicit leadership theories iranian context according available themes literature employees emotionally mature decisive three novel prototypes narrow new anti prototype moreover first study using interview discover inclusion data retrieved participants semantic memory
false memory rejection enhanced individuals rely based inferences remember event happened present study investigated whether year olds adults trained engage based inferences reject false highly familiar increased events across two experiments participants series actions differing expected two weeks later half participants received based training administered old new recognition test asked endorse actions thus actions rejected face high familiarity results indicated adults children exhibited increased rejection false events high following training procedure explained functioning based inferences experiment childrens rejection familiar events improved training procedure closely demands retrieval test experiment theoretical practical implications discussed elsevier inc rights reserved
study question ulipristal acetate upa used emergency contraception interfere human embryo implantation process summary answer upa dosage used affect human embryo implantation process vitro known already single pre dose upa acts delaying inhibiting ovulation recommended first choice among emergency contraceptive pills due efficacy compound also demonstrated dose dependent effect theoretically impair endometrial direct action human embryo implantation yet studied study design size duration effect upa embryo implantation process studied vitro endometrial construct human embryos randomly added cultures cultured days upa vehicle alone record attachment embryos participants materials setting methods endometrial biopsies obtained healthy fertile women cycle day stromal epithelial cells isolated three dimensional vitro endometrial culture system constructed mixing stromal cells collagen covered layer epithelial cells cultured progesterone containing medium treatment group received upa healthy viable human embryos placed control treatment cultures five days later cultures tested attachment embryos endometrial constructs analysed endometrial markers real time pcr main results role chance significant difference embryo attachment rate upa treated group control group human embryos exposed upa embryos control group attached endometrial cell surface known genes studied genes significant regulation genes namely regulated exposure upa compared control group limitations reasons caution proof concept study conducted human embryos availability limited although model used study established artificial endometrial luminal epithelium shown express progesterone regulated markers endometrial still vitro model lacking cell types constitute receptive vivo wider implications findings study provides new insights mechanism action upa human embryo implantation demonstrating upa dosage used affect embryo viability implantation process embryo progesterone receptor modulators hold potential attractive estrogen free contraceptives thus made available larger proportion women globally due findings
objective study examines socio demographic clinical characteristics influence suicide risk among large urban sample children ages younger receiving psychiatric emergency services methods bivariate binomial logistic regression analyses employed analyze data sample urban children presenting pediatric results approximately patients presented history suicidal thought behavior despite larger number black children presenting found significant difference suicide risk across ethnic group though prevalence rates increasingly higher whites black respectively presenting suicidality diagnosed behavioral disorder diagnosed mood disorder psychotic disorder another disorder one ten suicidal cases admitted prior child abuse furthermore patients admitted hospital suicidality likely female mood disorder appropriately discharged inpatient setting following initial hospital care conclusions study points importance screening insured medicaid urban children experiencing psychological distress regardless ethnicity age suicide risk clinicians consider findings working children psychiatric crisis published elsevier ltd
clean high energy efficient microwave drying system gained popularity wide variety food preservation processing bio main advantage acceleration drying process quite limited comparing conventional hot air drying system however microwave drying process pressure temperature increase continuously cause undesired side effects degradation physical damages order eliminate mentioned problems enhance higher performance control system flexibility paper design multi stage phase controlled converter microwave drying system proposed objective multi stage power control track drying characteristics microwave drying process different power level depending stage drying cycle period control approach achieved controlling triggering events appropriate phase angle based predefined power profiles varying pulse width average power output controlled focus paper hardware design component discussed system control algorithm based microcontroller arduino also presented details experimental results proposed multi stage control converter investigated discussed
growing interest description short lived patterns spatiotemporal cortical activity monitored via neuroimaging traditional analysis methods designed estimate relatively long term brain dynamics always appropriate capture patterns introduce novel data driven approach detecting short lived fmri brain activity patterns exploiting density peak clustering approach reveals localized clusters identifying grouping together whose time series similar irrespective brain location even short time windows similar volumes used method call coherence density peak clustering first tested simulated data compared standard unsupervised approach fmri analysis independent component analysis identifies activated essentially false positives proves reliable number false positives comparable true positives reliability method demonstrated real fmri data simple motor task containing brief iterations movement clusters identified found regions expected involved task repeat paradigm methodology proposed especially suitable study short time brain dynamics single trial experiments event task interest repeated subject happens instance problem solving learning decision making implementation method available https wiley periodicals inc
objective aim study evaluate usefulness mac binding protein glycosylation prediction post liver failure hepatocellular carcinoma hcc patients summary background data novel serum marker liver fibrosis usefulness prediction evaluated methods clinicopathological data analyzed hcc patients underwent liver resection august november evaluated according definition international study group liver surgery performance preoperative parameters predicting determined using receiver operating characteristic roc analysis results serum level correlated fibrosis score levels hepatitis virus hcv positive patients significantly higher hcv negative patients even fibrosis stage grade developed patients area roc curve prediction grade multivariate analysis odds ratio confidence interval platelet count resection rate significant factors associated grade index defined factors notably patients predictive ability best among preoperative parameters conclusions useful predictor especially patients hcv infection
new approach control electro magneto mechanical system proposed paper conventionally systems controlled based maxwell system model via pid control technique displays acceptable performance low frequency region high frequency region position control performance greatly degraded order improve performance newly developed virtual order system modeling technique adopted complex electro system study technique states unknown system exposed random disturbance unknown intensity identified terms virtual order system model via inverse process certain stochastic analysis typical hybrid system valve used target electro magneto mechanical system study modeling virtual order system order confirm performance proposed control strategy pid controller pwm mode utilized simulations based conventional maxwell system model control via pid proposed virtual order system model approaches conducted using matlab simulink performance three systems low high frequency bands also compared simulation results reveal control performance virtual order system model much improved compared maxwell system model pid controls low high frequency regions error drastically reduced approximately original value
ovarian cancer sixth common cancer among women prognosis favorable diabetes mellitus hypothesized associated higher mortality ovarian cancer patients evidence inconsistent thus aim investigate associated long term cause long term cancer specific mortality ovarian cancer patients synthesizing available epidemiologic evidences used electronic databases pubmed embase web science scopus search eligible articles title abstract screening full text review data extraction quality assessment performed reviewers independently meta analysis studies reporting risk ratio hazard ratio investigated association mortality patients synthesized random effect model subgroup sensitivity analyses performed certain stratification restrictive rules publication bias assessed plots test statistical heterogeneity evaluated squared value chi squared test cochrane statistic twelve cohort studies involving outcome measures included overall meta analysis synthesized cause mortality without substantial statistical heterogeneity cochrane synthesized cancer specific mortality substantial heterogeneity cochrane publication bias observed results suggest associated higher cause cancer specific mortality ovarian cancer patients future studies done examine association type ovarian cancer mortality
part syndrome behavioral phenotype significant impairment expressive communication begins early impairments verbal observed infants syndrome contrast social interaction relative strength replicated intervention procedures using social reinforcement prompting teach infants syndrome sounds engage increasingly sophisticated forms social instrumental requests examined generalization changes problem solving infants learned make requests showed generalization novel sounds different semi structured assessment infants also showed verbal naive improvements problem solving suggesting intervention broader effects just verbal
use levonorgestrel lng taken day women relatively infrequent sex efficacious safe acceptable contraceptive method typical use lng taken within sexual intercourse provides contraceptive efficacy pregnancies per women years primary population pregnancies per population lng effective emergency contraception following unprotected intercourse users take repeatedly means regular contraception prospective open label single arm multicentre phase iii trial study women infrequent days month woman follow visit months admission pregnancy occurs decided participation study conducted january november total healthy fertile women aged years risk pregnancy reported sexual intercourse days month recruited four university centres located thailand brazil singapore use lng primary method contraception participants instructed take one tablet every day sex without taking one tablet period maintain paper diary recording date time every act ingestion study tablet use contraceptive methods vaginal bleeding patterns assessed evaluation pregnancy tests performed monthly pregnancies occurring product use assessed ultrasound month final visit months acceptability questions administered women included population includes eligible women enrolled woman years observation rate confidence interval pregnancies per typical use reflects use study drug main contraceptive method also includes possible use contraceptives admission end study pregnancies per sole use primary population includes eligible enrolled women years old rate pregnancies per typical use pregnancies per sole use three reported severe adverse events mild adverse events common headache nausea abdominal pelvic pain high recovery rate vaginal bleeding patterns showed slight decrease volume bleeding number bleeding free days increased time one case severe found final visit method considered acceptable participants choose use future recommend others single arm study small sample size without control group designed proof concept study explore feasibility type contraception larger clinical study evaluating contraception lng feasible data show method acceptable many women study received partial financial support world bank special programme research development research training human reproduction department reproductive health research world health organization gates foundation provided financial support project monitoring lng product initial project manager employed lng emergency contraception authors conflicts interest study registered trial october january
purpose paper aims present experimental results gasoline engine operation two stroke cycle engine used unmanned air vehicle uav unmanned air system application cross correlate computational fluid dynamic modelling results design methodology approach computational modelling engine system conducted using wave software supported experimental research development via testing spark ignition uav engine construct validated computational model exploring range fuel delivery options findings experimental test data computational simulation allowed assessment potential advantages applying direct cylinder fuel injection practical implications ability increase system efficiency offers significant advantages terms limited resources extending mission duration capabilities computational simulation validation via experimental test experience provides means assessment possibilities costly explore experimentally offers added confidence able investigate possibilities development similar future engine designs originality value software code used applied two stroke cycle engines provides valuable facility simulation twin cylinder opposed design offer system optimisation exploration future possibilities
background purpose sensory patients symptoms airways chest induced environmental like products cigarette smoke characterized increased cough reaction inhaled compared healthy controls lung function tests normal asthma medications little effect recent published article patients found impaired chest mobility increased pain sensitivity purpose study evaluate intervention increase chest mobility influence patients symptoms reduce cough sensitivity methods forty one patients initially randomized groups one training one symptom registration controlled training study consisted daily training programme containing simple movements increase flexibility chest breathing exercise relaxation session symptom registration chest expansion measured measuring tape thoracic abdominal movement light sensors pain sensitivity assessed using pressure standardized inhalation threshold evaluated cough sensitivity results twenty seven patients left analyses weeks patients weeks chest mobility upper thoracic respiratory movements improved feeling chest pressure cough sensitivity decreased patients also showed significantly lowered pain pressure thresholds measured compared healthy controls conclusion improvement chest mobility intervention indicates patients acquired dysfunctional breathing pattern regular use training programme structural breathing instructions used improve chest mobility chest symptoms cough sensitivity patients signs dysfunctional breathing copyright john wiley sons ltd
current paper provides overview cultural religious background pakistan current situation mental health pakistan special emphasis cultural adaptation cognitive behaviour therapy cbt pakistan context mindfulness interesting note easy explain concepts cbt therapists clients pakistan process culturally adapt cbt culture based generating evidence group taken responsibility far successful pertaining research service development described paper
synthesize active anti asthmatic drug catalytic asymmetric transfer various prepared performed products exhibit moderate high particular acyl substituted substrates yields secondary good yield furthermore synthesized one step resulting secondary alcohol without
paper presents dynamic model solar steam receiver electricity generation receiver mono tube cavity mounted focal point australian national university dynamic model derived physical principles mass energy conservation uses moving boundary formulation coupled switching approach represent outlet flow ranging sub cooled liquid steam method compute outlet mass flow rate three receiver outlet flow conditions included modelling approach results compact state space representation receiver useful development model based control strategies operation receiver plant model implemented validated experimental data australian national university system elsevier ltd rights reserved
article describes efficient methods visualize results finite element analysis implementation methods post processing results work based premise computer memory performance limited amount data processed complex finite element analysis enormous therefore kind simplification approximation resulting data used method research work development post processor stored data finite element analysis discrete values paper deals several ways replacing continuous functions suitable representation computer graphics different approximation functions used finite element method special attention devoted approximation errors difference functions finite element mesh decomposed sub domains respect approximation errors ways creating mesh hierarchy described details also possibilities nodal value simplified mesh discussed text besides approximation data space also approximation time used pseudo code approximation algorithm key parts shown various types approximation functions investigated reach lowest approximation error highest compression factor results summarized article elsevier ltd rights reserved
throughout life animals progressively accumulate mostly detrimental changes cells tissues functions causing decrease individual performance ultimately increased risk death latter amplified also leads deterioration immune system forms important protection permanent threat pathogens infectious diseases investigated four baseline innate immune parameters natural antibodies complement activity concentrations concentrations nitric oxide changed age free living great major applied cross sectional longitudinal approaches birds sampled three years lives three four selected innate immune parameters affected age however shape response curves differed strongly among innate immune parameters natural antibody levels increased early life mid age decrease thereafter birds aged complement activity highest young birds levels slightly decreased increasing age levels hand showed linear highly variable increase age nitric oxide concentrations unaffected age observed differences among four studied innate immune traits indicate importance considering several immune traits time also highlight complexity innate immunity functional significance observed changes innate immunity thus challenging next step elsevier inc rights reserved
background frequency severity injury soccer unknown purpose estimate incidence rates characteristics risk factors injuries associated soccer study design cohort study level evidence methods sports physician examined recorded injuries incurred japanese national soccer follow made injuries match exposure player recorded video review examine individual risk factors results total injuries recorded matches overall injury rate time loss injury rate per player hours foot frequently injured area followed lower leg ankle injury frequent injury type followed sprains ligament injuries injuries resulted days time loss adjusting age previous history severe injury longer experience soccer significantly associated injury risk conclusion time loss injury rate study comparable rates reported matches soccer however greater incidence foot injury lower incidence ankle injury distinguished soccer soccer possibly related specific playing conditions sand surface
research correlates antisocial behavior revealed importance integrating findings evidence flowing genetics neuroscience present study represents step toward integration offering depth overview study brain affects antisocial behavior consider role brain antisocial criminal behavior drug use abuse highlight various regions systems brain identified targets intervention areas need study knowledge foundation think promote mental health adaptive behavior among drug using criminal offenders
term refers continuum personality characteristics emerging mental states ranging organized normal disordered latter include individuals high scores diagnosed personality disorder evidence studies found relative weakness inhibitory functioning including inhibition ppi sensory gating eye movement schizophrenia schizophrenia spectrum understanding nature sensory motor inhibitory weakness associated optimize prevention intervention schizophrenia populations review aims examining deficits sensory gating control inhibition examining relationship three measures symptoms traits examining effect nicotine three measures examining relevant brain regions three measures searched multiple databases medline pubmed google scholar using combinations keywords personality disorder inhibition sensory gating articles published english since found three measures ppi associated major symptoms suggesting three measures used predict disease etiology prognosis secondly three measures modulated nicotine administration certain level providing potential tool study role nicotine cognition symptom improvement brain imaging studies localized activity brain regions associated sensory gating control inhibition search brain regions target treatment prevention overall three measures suggested valuable tool study inhibitory deficits used tool prevention treatment published elsevier
work designed counting machine terms power efficient circuit using family three different standards mobile three different standards compared basis clock power logic power signal power ios leakage power total power consumption search power efficient one order find efficient circuitry collected data power consumption three standards compare analysed circuitry different frequencies experiment power saving used place using mobile also concluded replace frequency power saving achieved design energy efficient counting machine using hdl simulator fpga
data exist adverse drug reactions elderly people group pharmacotherapy represents challenge regard comorbidities drug interactions compliance aim article highlight characteristics elderly patients addition literature review present first data research center diseases life total subjects aged years randomly included population based age sex standardized investigation inhabitants germany special emphasis placed allergies including questions regard subjects data allergies available subjects female gender comorbidities use multiple drugs significantly associated increased risk women also reported significantly frequently men subjects reported suffering form result medications reaction occurred within previous months less life patients document giving details occurrence significantly contributes morbidity elderly patients prevention knowledge patient related factors underlying diseases drug characteristics drug interactions necessary
physical examination swelling first step making diagnosis many times see patient spherical swelling usually interpretation physical signs based sound principles physics present paper explain physical characteristics swelling using principles fluid mechanics
paper concerned problem model reduction neutral type control system given stable neutral type control system attention focused construction reduced order model original system robust performance also translated linear lower dimensional system sufficient condition proposed asymptotic stability error performance error system model reduction problem solved using projection approach model reduction subject linear matrix inequality constraints employing cone complementary linearization algorithm moreover extending results model reduction special structures obtained neutral type model numerical simulation example provided demonstrate effectiveness applicability proposed controller design approach
selection optimal parameters design electric motor multivariable multimodal optimization problem requires considerable amount computational calculation time solve type problem paper proposes novel multimodal optimization algorithm assisted surrogate model using newly developed compressed sensing theory effectiveness confirmed comparing optimization results test functions results conventional optimization methods results show proposed method rapid accurate convergence characteristics conventional approaches verify feasibility application electric motors wheel motor designed using proposed algorithm
power distribution grid exhibits characteristics weak grid owing existence scattered high power distributed power generation devices grid impedance affects robust stability grid connected inverters leading harmonic resonance even instability system therefore study stability grid connected inverters high grid impedance based impedance analysis presented paper output impedance modeling type single phase grid connected inverter derived effects loop digital control delays output impedance characteristics taken account enhance stability grid connected inverters different grid impedance novel impedance compensation control strategy proposed increasing phase margin grid connected inverters specifically detailed implementation parameter design impedance compensation control method depicted finally impedance dynamic control scheme combined online grid impedance measurement introduced also verified experiment results
flexural bending analysis perfect functionally graded materials plates thermo mechanical loading investigated present paper due technical problems fabrication micro created inside samples lead reduction density strength materials investigation plates assumed even uneven distributions plate cross section modified rule mixture used approximate material properties plates including porosity volume fraction order elastic coefficients thermal coefficient moisture expansion coefficient plate assumed graded thickness direction elastic foundation modeled two parameter foundation equilibrium equations given number examples solved illustrate bending response metal ceramic plates subjected thermo mechanical effects resting elastic foundations influences played many parameters investigated
self esteem generally regarded important indicator adolescents mental health assessed self report questionnaire school sample subjects assessed time points years years age within psychology psychopathology study cross lagged panel analyses longitudinal data indicated self esteem predictive internalizing problems impact internalizing symptoms analyses adjusted coping behavior efficiency social networks impact stressful life events self esteem also stable within observed age range controlling prior levels predicted variables findings support impact self esteem mental health indicate importance addressing self esteem prevention intervention programs
aim paper demonstrate applicability effectiveness computationally demanding stereo matching algorithm different low cost low complexity embedded devices focusing analysis timing image quality performances various optimizations implemented allow deployment specific hardware architectures decreasing memory processing time requirements reduction color channel information resolution input images low level software optimizations parallel computation replacement function calls loop reduction redundant data structures internal data representation feasibility stereo vision system low cost platform evaluated using standard datasets images taken red cameras analysis resulting disparity map accuracy respect full size dataset performed testing suboptimal solutions
remarkable advances made treatment inflammatory bowel disease since introduction anti tumor necrosis factor alpha agents especially patients refractory tolerate conventional therapies currently infliximab adalimumab available east asian medical market agents shown effective inducing maintaining long term remission inflammatory bowel disease despite clinical benefits anti tumor necrosis factor therapy also lead increased vulnerability infections development autoimmune diseases malignancy decreased immunogenicity infectious diseases tuberculosis hepatitis influenza remain major health problems east asia use biologics needed improve treatment efficacy safety close monitoring inflammation regular surveillance malignancy regularly scheduled needed treatment strategies biologics customized meet needs different patients
introduction increasingly imperative retain new graduates order meet growing health workforce needs ageing population concurrently need prepare graduates work effectively teams providing educational opportunities tertiary level although skills knowledge competencies delivered context point limited attention given identification gaps entry level work readiness graduate health professionals subsequently addressed extent education methods qualitative responses collected department health western australia employees using survey tool open fields respondents recent graduates across range health responses analysed identify significant self reported gaps graduate work readiness impact results gaps entry level work readiness across multiple identified included time management clinical administration skills lack experience high risk patients insufficient transform theory practical knowledge conflict management stress management reality shock conclusion gaps identified current graduate work readiness across range health inform focus future training paper play role ensuring graduates work ready also provide ideas building skills future workforce
often attractive attributes printed organic electronics mechanically flexible form factor low cost green demand printing scalability low power operation intelligence signal processing ideally creation intelligent lightweight electronics printed simple ubiquitous printing processes integrated new ways exploit mechanically flexible form factor printed organic electronics now industry right recognized one key technological internet things largely complementary silicon printed transistors slow printed elements large projected growth market today assumes intelligence analog mixed signal digital signal processing nevertheless many said attributes printed organic electronics remain challenge paper exemplify comprehensive critical review state art printed digital analog mixed signal circuits review application space printed organic electronics supply chain including classifications delineate associated challenges constituent chain challenges largely unresolved indeed discussed critical circuits systems perspective review contemporary design methodologies silicon largely inadequate printed organic electronics end discuss analog digital design methodologies emphasis design optimization different constituent supply chains potentially circumvent said challenges discuss associated
study aims conduct nonlinearity analysis effect technical economic performance building integrated photovoltaic blind designed preliminary study evaluate feasibility implementation first terms technical performance effect due nonlinear effect amount electricity generation per unit area particularly width panel increases unit tends decrease second terms economic performance feasibility depends type investment values specifically width panel increases net present value year tends increase however saving investment ratio year tends decrease determined highest width panel determined highest times width panel main findings study used clearly define design specifications implementation ensure meet client expectations various objectives technical performance unit economic performance elsevier ltd rights reserved
study proposes novel method eliminate limit cycle caused low resolution analogue digital converter adc digitally controlled converter reduced state kalman filter proposed get optimum estimate output voltage noisy measurement provided low resolution adc proposed scheme simulated bit resolution adc validation performed different resolutions using prototype model implemented bit digital signal processor results show proposed scheme eliminates limit cycle oscillation completely computationally efficient
veterans largest integrated health care system united states responsible care population disproportionately high rate ckd ensuring access kidney health services imperative one facet vas strategy reduce ckd leverage use expand vas outreach veterans kidney disease wide array services deployed pull veterans push kidney health services veterans preferred health care thus expands choice facilitates access care goal delivering patient centered kidney specialty care demonstrated feasibility virtual delivery kidney specialty care services education via synchronous asynchronous approaches challenges ahead include determining relative health care value kidney services identifying veterans likely benefit specific technologies optimizing adoption effective kidney services providers patients alike ensure optimal timely kidney health care delivery
comprehensive mathematical model proposed calculate optimal leg length cross section area unit maximize peak output power model shows unit exists optimal ratio leg length leg cross section area corresponding maximum peak output power convective thermal boundary condition optimal leg length cross section area calculated based optimal ratio mathematical model also validated paper corresponding error within reasonable range moreover effects leg length leg area peak output power peak output power density efficiency unit different thermal boundary conditions also discussed study provide guidance structure design optimization unit elsevier ltd rights reserved
new approach unified treatment frictional contact plasticity finite strains using semi smooth newton methods presented contact discretization based known finite element method using dual facilitate handling additional multiplier degrees freedom exploiting similarity typical inequality constraints plasticity friction involved discrete inequalities nonlinear non smooth equations using functions resulting set discrete semi smooth equations solved efficiently variant method additionally introduced variables global system linear system consisting displacement degrees freedom solved iteration step contrast classical radial return mapping methods computational plasticity plastic constraints required hold every nonlinear solution procedure convergence relaxation pre asymptotic behavior results increased flexibility regarding algorithm design potentially higher robustness compared radial return mapping algorithms presented plasticity algorithm includes arbitrary anisotropic type yield function kinematic plastic spin appropriate finite element technology nearly incompressible materials therefore suited modeling sheet metal forming similar processes several numerical examples underline robustness proposed plasticity algorithm efficient treatment plastic contact problems elsevier rights reserved
studies shown people use ability experience secondary emotions compared primary emotions characteristic result widely supported extensive range research work however still know certain conditions tendency mitigated aim study twofold one hand determine whether intergroup context results human representation hand verify bias mitigated purpose three elaborated first included description outgroup german people second described taking war finally text dealing general without specific reference german people presented two step experimental design first participants attribute secondary primary emotions outgroup answer decision task registered strength association secondary emotions ingroup outgroup results show intergroup contribute representation outgroup reduce bias
background clinical trial data shown oral inhibitor efficacious safe treatment psoriasis however little real world experience using community setting documented objectives many patients psoriasis often various treatment modalities including topical systemic biologic medications aim chart review assess overall patient experience using treat psoriasis methods retrospective chart review electronic medical records conducted patients prescribed community dermatology practice results patients prescribed patients took least dose patients improved clinical disease severity patients achieving body surface area treatment generally tolerated caused serious adverse events commonly reported side effect resulting discontinuation treatment nausea vomiting conclusions overall safe tolerated treatment significant clinical improvement patient population
osteoarthritis one common chronic diseases characterized degradation articular cartilage previously reported injection preparation high molecular weights ranging enhance viscosity synovial fluid protect joint cartilage rabbit effect significance difference existing clinical medication sodium injection frequency weekly weeks herein prepared injection preparation low ranging evaluated effect therapy every weeks weeks weekly weeks reference model induced using anterior cruciate ligament rabbit vivo also using sodium snp cell culture vitro results showed also protect cartilage damage decrease concentration nitric oxide synovial fluid reverse amplification knee joint width similar previously reported cellular level promotes proliferation decreases apoptosis chondrocytes mechanistically molecular level effects elicited via regulation protein levels caspase bax regulation protein levels bcl cartilage vivo vitro results showed become excellent candidate long acting drug treating published elsevier ltd
present approach scalable long term preservation data stored relational databases implemented semantic query system proposed approach suitable scientific data used scientific publications desirable preserve parts data specific set experimental database approach long term preservation selected parts database specified query extended query processing based automatically generating view relational database called view provides flexible selection data terms like query view result query data file containing representing relational data content preserved system also generates schema file sufficient meta data saved allow database fully reconstructed query usually properties values sets subjects makes property triple patterns unknown call queries properties unknown property queries achieve scalable data preservation propose query transformation strategies suitable optimizing property queries query strategies implemented evaluated new benchmark queries called defined set typical queries selected parts databases generated benchmark data generator experiments optimization strategies evaluated measuring performance queries selecting performance equivalent queries related systems also measured results showed proposed optimizations substantially improve query execution time queries
use internet among adolescents opportunity personal development also potential source problems risks social cultural aspects related gender priori determine patterns internet social networks usage resulting consequences aim present study explore possible gender differences regarding internet usage habits reasons use online risky behaviors problematic internet use parental role achieve goal sample spanish secondary school students aged analyzed results obtained confirmed relevant gender differences reasons using social networks mobile phone instant messaging use differences prevalence risky practices parental role also detected findings allow discussing keys gender perspective
paper presents results pilot scale study consisting pre treatment granular activated carbon filter followed membrane filtration detailed characterisation rainwater tanks highlighted turbidity dissolved organic carbon heavy metals particular lead compliant australian drinking water guidelines organic matter present water causes membrane leads carcinogenic compounds upon filter used first step remove dissolved organic matter measured terms particular also reduce concentration turbidity lead membrane filtration remove remaining solids reducing concentrations turbidity microorganisms study pilot scale rainwater treatment system consisting gravity fed filter membrane filter ultra operated period days performance system assessed terms membrane flux improvement water quality measured australian drinking water guidelines determination flux especially later stages membrane operation important able size filters manner meets expected demand treatment system filter membrane filter effective reducing turbidity heavy metals system reduced turbidity levels limit concentration reduced australian drinking water guidelines limit concentration lead reduced less limit concentrations heavy metals within limits filter removed majority organic substances raw rainwater collected roof initial flux decline stable flux achieved consistently final days experiment
classifying measurement data become core problem photogrammetry computer vision since rise modern geometry techniques combined affordable range sensors introduce markov random field based approach meshes generated via multi view stereo urban classes interest input mesh first partitioned small clusters referred geometric features computed random forest trained predict class similarity neighboring similarity used assign weights markov random field pairwise potential account contextual information classes experimental results illustrate efficacy accuracy proposed framework published elsevier behalf international society photogrammetry remote sensing inc
paper examines cytotoxic effect nine compounds structures determines reaction mechanism selected binding ability human serum albumin cytotoxic effect determined two human cell lines melanoma cells normal human umbilical vein endothelial cells highest cytotoxicity exhibited compound found less three cancer cell lines five fold lower sensitivity normal cells compounds exhibit comparable affinity energy human serum albumin binding mol vary binding sites depending ray two derivatives confirmed synthetic pathway structures carefully examined elsevier rights reserved
outbreak acute hepatitis recently occurred nursing home province china objectives study confirm outbreak identify aetiology source transmission patterns residents staff near nursing home period october investigated regarding hygiene epidemiological information including water food eating meat especially products serum stool specimens collected detection hepatitis virus hev antibodies using elisa rna using pcr samples rna positive genotyped senior residents staff nursing home laboratory confirmed cases outbreak cases patients three deaths symptomatic common clinical symptom hepatitis infection hev strains isolated three cases formed single cluster within genotype case control study conducted investigate potential risk factors outbreak results revealed cases often using tap water controls based hygiene investigation meteorological information likely hev infected sewage contaminated water network rainy days collectively results suggest outbreak hev genotype infection likely caused contaminated tap water rather food
combination electric motors internal combustion engines hybrid electric vehicles hev considerably improve fuel efficiency compared conventional vehicles order use full potential predictive intelligent control system using information driving situations developed determine optimal gear shifting strategy torque split combustion engine electric motor increase fuel efficiency vehicle velocity used additional degree freedom development predictive algorithm calculating good choices degrees freedom time necessary paper optimization based algorithm combined energy management economic driving limited horizon proposed results compared results offline calculation determine overall fuel savings potential use discrete dynamic programming algorithm elsevier ltd rights reserved
cancer testis antigens promising targets immunotherapy due restricted expression germ cells testis healthy tissue high immunogenicity aim present study determine whether transmembrane protein antigen investigate pattern expression progression melanoma pattern expression human mrna multiple human tissues determined reverse transcription polymerase chain reaction analysis protein expression analyzed human testis addition primary melanoma metastatic melanoma samples immunohistochemistry analysis identified predominantly expressed testis weakly expressed placenta addition protein expression detected melanoma samples primary metastatic intensity staining metastatic primary determined integrated optical density analysis identified significantly increased metastatic melanoma compared primary melanoma area expression protein significantly increased metastatic compared primary melanoma samples results present study suggest novel antigen serves essential role melanoma metastasis addition potential target treatment patients melanoma
increasingly requirement able determine mechanical properties materials micro scale form surface coatings iii nanoscale microstructures consequence micro scale testing important tool developed aid evaluation mechanical properties materials work cantilever beam specimens typically size prepared ion milling deformed situ within dual beam latter achieved using force probe geometry suitable loading micro scale test specimens thus force displacement measured together observing deformation fracture individual specimens paper considers evaluation mechanical properties particular elastic modulus yield strength fracture strength materials result relatively large micro scale cantilever beams two materials considered first linear elastic single crystal silicon elastic plastic nickel results discussed respect reproducibility method mechanical testing evaluated properties compared derived alternative procedures
one class classification basic problem machine learning unlike existing typical one class classifiers designed angle probability geometric paper attempts study problem point view using continuous cognition characteristic starting point propose new framework one class classifier named multiple regression model seen natural extension multiple regression one class classification problem paper applies least squares support vector machine example show modeling process proposed method corresponding one class classifier named one class least squares support vector machine various simulation real life datasets used test performance proposed existing popular one class classification methods including kernel density estimation support vector data description gaussian mixture model also applied order achieve comprehensive comparison results show achieved best performance simulation real life datasets due good robustness highlights efficacy elsevier rights reserved
aims postural syndrome represents autonomic disorder predominantly affecting females years age chronic disorder months characterized excessive heart rate increment standing min presence characteristic symptoms cerebral sympathetic activation patients clinically noted describe lower urinary tract symptoms luts although symptoms assessed population herein present data pilot study designed identify overactive bladder oab patients diagnosed methods patients admitted autonomic dysfunction center june october evaluation potential diagnosis completed validated standardized questionnaire oab oab presentation symptom score subscale analyses conducted subscale health related quality life scores transformed scale higher scores reflecting superior data presented results thirty two females presented evaluation symptoms consistent twenty nine women subsequently diagnosed patients completing oab questionnaire response rate average age years symptom severity transformed score patients meeting clinical criteria diagnosis probable clinically significant oab nocturia symptom followed increased daytime frequency urgency conclusions pilot study describes lower urinary tract dysfunction patients presenting assessed patient reported questionnaire data nocturia demonstrated greatest negative impact health related quality life social interaction least affected domain patients data provides critical baseline mechanistic insight disease specific global pathophysiology nocturia oab neurourol urodynam wiley periodicals inc
article describes detail procedures isolation small rna molecules electrophoresis northern blotting finally detection hybridization labeled presented protocols successfully introduced used laboratory
autism spectrum disorders asd schizophrenia spectrum disorders share clinical genetic components long recognized two disorders occur frequently predicted respective prevalence suggesting complex association involved however dsm maintains distinction asd core social communication impairments including schizophrenia hallucinations thought disorder essential features asd common biological underpinnings emerge early development time one hypotheses supporting similarities social cognitive disturbances asd relates abnormalities ratio excitatory inhibitory cortical activity imbalance imbalance neurodevelopmental disorders consequence abnormalities genes coding glutamatergic receptors synaptic proteins followed system asd characterized disorders onset progression disease triggered interactions among multiple genes mammalian target rapamycin signaling intense investigation convergent altered pathway two spectrum disorders current understanding shared divergent patterns asd molecular clinical aspects still incomplete implemented research domain criteria approach
background aim comparative study evaluate clinical radiological outcome open treatment acute anterior fractures analyze influencing factors complications patients methods study included patients average age years range years surgery mean period follow years range years average extent fracture involvement range three fixation techniques applied small fragment results mean score values points absolute constant score points normalized constant score points score points shoulder score points simple shoulder test points shoulder pain disability index subjective shoulder value fixation technique show significant influence however multi fragment fractures associated significantly inferior absolute points normalized constant scores points insufficiency internal rotation deficit found patients posttraumatic osteoarthritis occurred patients conclusion open fixation yielded good excellent shoulder function patients clinical outcome primarily depended underlying type fracture significantly inferior outcomes expected patients multi fragment fractures main complications insufficiency posttraumatic osteoarthritis
uncertain systems actuated smart material based actuators systems exhibit hysteresis nonlinearities corresponding control becoming challenging task especially actuators dominated asymmetric common approach overcoming hysteresis effect inverse compensation combining robust adaptive control focusing asymmetric hysteresis phenomenon asymmetric shifted model inverse developed corresponding analytical expression inverse compensation error derived prescribed adaptive control method applied mitigate compensation error simultaneously guaranteeing global stability closed loop system prescribed transient steady state performance tracking error without knowledge system parameters effectiveness proposed control scheme validated actuated platform elsevier ltd rights reserved
objective describe evolution serological markers among hiv hepatitis patients emphasis evaluating reactivation markers methods study population consisted patients met aids outpatient clinic state brazil included analysis hiv infected underwent least two positive hepatitis surface antigen serological testing clinical follow tests taken six months apart patients tested commercial kits available hepatitis serological markers enzyme immunoassay clinical variables collected age sex cell count hiv viral load alanine aminotransferase level exposure antiretroviral drugs including results among hiv positive patients identified patients chronic hepatitis follow time patients varied six months years patients underwent antiretroviral therapy follow among patients chronic hepatitis hepatitis antigen positive first assessment clearance hepatitis surface antigen occurred patients chronic hepatitis patients presented subsequent reactivation hepatitis surface antigen among hepatitis antigen positive patients presented clearance marker clinical follow initially hepatitis antigen presented reactivation marker conclusions among hiv patients antiretroviral therapy changes hbv serological markers frequently observed results suggest frequent monitoring serum markers recommended
dna emerging smart material construct targeted drug delivery base enables construction defined dynamic dna nanostructures almost arbitrary shape dna readily functionalized variety molecular modules applications dna nanostructures still infancy one high expectations deliver solutions targeted therapy nucleic acids however easily enter cells biological barriers harsh conditions human body also overcome highlight recent strategies dna nanostructures drug delivery dna facilitate targeting crossing biological barriers light discuss future solutions challenges dna unravel great potential facilitate targeted drug delivery elsevier rights reserved
higher education understood essential enabling social mobility research policy centred access university recently attention turned social mobility costs long distance extreme social mobility particularly require analysis paper examines first family university students especially high status degree medicine interviews students australian medical school three themes discussed roots participants social mobility sociocultural difference experienced within medical school participants think professional identities students described getting medical school hard way different backgrounds attitudes peers many felt like using self language highlight lack fit world medicine however language also reflected resistance middle class norms served create community origin importantly patients rather narratives loss students stories reflect refinement self incorporation certain middle class attributes alongside appreciation worth difference brings new destination medical profession
recently growth interest novel skin care formulations containing active ingredients low molecular weight peptides paper present new formulations oil water water oil emulsion containing acetyl pro pro formulations characterized terms physicochemical parameters viscosity stability particle size distribution additionally diffusion parameters peptide obtained formulations calculated based equation furthermore order determine penetration membranes release kinetics investigated basis release curves release rate constants determined results proved properties formulations strongly determined release rate higher viscosity slower membrane elsevier rights reserved
hostile attribution bias tendency interpret intention others hostile ambiguous social contexts associated impulsive aggression adults results mixed complete sequence hostile processes leading aggression investigated yet goal event related brain potentials study track neural activity associated violation expectations hostile versus intentions aggressive individuals examine neural activity relates self reported hostile bias impulsive aggression real life end scenarios hostile versus social context followed characters ambiguous behavior presented readers critical words specified hostile versus intent behind behavior analysed thirty seven aggressive fifty individuals participated study presentation critical word hostile expectation caused response significantly larger aggressive individuals results also showed enhanced late positive potential like component aggressive individuals hostile intention scenarios took place context associated impulsive aggression real life even controlled effect self reported hostile bias hostile expectancy violation paradigm evaluated study represents promising tool investigate relationship online processing hostile intent others impulsive aggression wiley periodicals inc
type functional variable method used private type nonlinear fractional differential equations main property method demonstrate flexibility ability solve nonlinear equations accurately efficiency conveniently fractional derivatives described modified riemann sense three examples presented show application present technique result periodic hyperbolic solutions obtained
purpose study develop health work survey examine validity discomfort rating scale data collected portuguese workers six economic sectors support health work survey self administered questionnaire assessing working conditions health wellbeing provide information occupational health systems organisations survey instrument validation partial credit model pcm used analyse item fit statistics application pcm person separation reliability obtained value considered good statistical analysis overall model fit information given mean square mean square meaning productive measurement acceptable fit overall items generate predictable response patterns recommend discomfort rating scale items reviewed future works event tool proves useful assessing relationship work health evaluating key main risk factors helping prevent problems improving occupational health systems
paper design testing based control unit used manage absorption employing white led light source described led technology allows perform absorption measurements reducing temperature variations thus noise generation occur light source usually employed used also thanks led technology system results low cost easy use low power consumption realized used atmospheric industrial pollutant detection indoor air monitoring hospital rooms able detect particulate matter pesticides volatile organic compounds pollution produced heavy metals realized system different required functionalities acquisition processing via raw data provided sensors actuation mechanical devices motor valve controlling data exchange hardware sections microcontroller hardware software sections designed carrying appropriate tests verify proper operation results confirm correct system functioning interaction via terminal user realized control unit
prospective memory refers ability remember execute future intentions taking medication although prior research prospective memory errors focused errors failures perform intention response target cue recent surge research commission errors erroneous performance finished intention existing studies examined factors retrieval lead commission errors present study extends research investigating impact encoding strength found relative standard encoding implementation intention encoding doubled risk commission errors laboratory paradigm young older adults novel finding demonstrates impact encoding strength commission errors documents potential challenges effects implementation intentions upon completion prospective memory task
following recent rapid development researches utilizing magnetorheological fluid smart material controlled change apparent viscosity lot applications established exploit benefits advantages using fluid one important applications fluid devices valve uses popular flow valve mode among available working modes fluid valve widely applied lot hydraulic actuation vibration reduction devices among actuators shock paper presents review valve discusses several design configurations mathematical modeling valve therefore review paper valve based coil configuration geometrical arrangement valve focusing four different mathematical models valve plastic viscous pre yield viscosity models calculating yield stress pressure drop valve design challenges opportunities application fluid valve also highlighted review review paper provide basic knowledge design modeling valve reviews fluid applications technologies
purpose study determine impact pocket satisfaction education countries former union linear indicates pocket satisfaction factor indicates pocket satisfaction percentage points time interaction model demonstrates negative impact paying pocket declines quality education improves quality education negative impact paying pocket grows considerably authors published elsevier ltd
background fragile associated syndrome adult onset disorder associated alleles gene disorder characterized progressive action gait cognitive decline fragile associated syndrome pathology includes white matter inclusions neurons astrocytes previously demonstrated transport iron brain altered fragile associated syndrome therefore also expect alteration iron metabolism brain areas related motor control iron essential cell metabolism iron leads oxidative stress contributes development neurodegenerative diseases investigated potential iron modification putamen structure participates motor learning performance fragile associated syndrome methods used samples putamen obtained fragile associated syndrome control cases study iron localization using method iron binding proteins using immunostaining results found increased iron deposition neuronal glial cells putamen fragile associated syndrome also found generalized decrease amount iron binding proteins decreased number neurons glial cells contained however found increased levels iron microglial cells indicating attempt immune system remove excess iron conclusions overall found deficit proteins eliminate extra iron cells concomitant increase cellular iron putamen fragile associated syndrome international parkinson movement disorder society
cell physiology impaired protein aggregation relevant inclusions neurodegeneration present study aimed characterize animal model enable analysis cell biology protein aggregation ten month old rats exposed either day delivered subcutaneously mini pumps one month tau alpha synuclein amyloid beta peptide protein indicative oxidative stress evaluated hippocampus substantia nigra locus immunohistochemistry western blot found day increased amyloid beta peptide tau alpha synuclein day alter protein levels protein remained unchanged study demonstrated aged rats exposed low dose useful model study cellular processes protein aggregation higher dose makes good model study effects protein inclusions
global demand foods growing algae increasingly consumed functional benefits beyond traditional considerations nutrition health substantial evidence health benefits derived food products remain considerable challenges quantifying benefits possible adverse effects first limited understanding nutritional composition across species geographical regions seasons substantially affect dietary value second issue quantifying fractions foods humans factors influence food constituents released ranging food preparation genetic differentiation gut microbiome third understanding nutritional functional constituents interact human metabolism considerations effects harvesting storage food processing techniques dramatically influence potential value derived foods highlight rapidly advancing area science particular focus key research required assess better health benefits product rich opportunities emerging field requiring exciting new experimental collaborative approaches
solar energy universally accepted potential alternative power source due availability diverse conversion technology environmental friendly nature hybrid photovoltaic thermal system optimized solar energy system produces electricity thermal energy simultaneously physical profile basic problem hybrid collector removal transfer heat efficient way article system novel design thermal collector excluding absorber plate introduced resolve mentioned problem parallel plate thermal collector without absorber plate attached directly module means thermal performance evaluated numerically validated experimental data different operating conditions numerical analysis system performed using finite element method fem based software outdoor experimental investigation done typical climatic condition malaysia elevation head water employed ensure passive cooling module numerical simulation results found agreement experimental measurements thermal performance without absorber plate found almost good absorber plate numerical experimental values maximum overall efficiency system found respectively irradiation level inlet ambient temperatures degrees developed simulation model extended designs thermal collector using different materials published elsevier ltd
enterprise network security solution optimization complex challenging problem given large number components involved paper describes project ultimate goal providing optimized solutions enterprise network security describe approach implementing optimized security assessment using genetic algorithm dynamic nature enterprise network security analysis tools devised network need function dynamic mode incorporated fuzzy logic controller fine tune optimization algorithm run time takes consideration exploration exploitation aspect calculates appropriate adjustments control parameters selection crossover rate possible attack paths identified evaluated based attack graph representing network study attack paths satisfy certain optimization criteria selected presented possible components security solution also carried comparative study performance adaptive used problem conventional results shows attack graphs analyzed adaptive yields significantly better solutions
investigation letter dimensional generalized breaking soliton equation describes dimensional interaction riemann wave propagating along axis long wave along axis analysis carried shown generalized equation property one set parametric choices integrable properties corresponding pain integrable equation bilinear form soliton solution bilinear backlund transformation lax pair infinite conservation laws derived binary bell polynomials elsevier ltd rights reserved
received much attention studies behavioral ecology physiology also provide informative characters identifying species review terminology variation calls perspective integrative taxonomy provide hands protocols recording analyzing comparing interpreting describing sounds focus calls serve isolation mechanisms therefore convey important taxonomic information provide recommendations terminology call note pulse fundamental subunits used descriptions comparisons however due complexity diversity signals application terms call note challenging therefore provide two coherent concepts either follow note centered approach defining units sound notes call call centered approach defining units call whenever separated long silent intervals terminology based surveys literature show numerous call traits highly variable within individuals one species despite species higher taxa duration calls notes pulse rate within notes number pulses per note appear static within individuals somewhat less affected temperature therefore variables often preferable taxonomic characters call rate note rate heavily influenced various factors dominant frequency also comparatively static weakly affected temperature depends strongly body size taxonomic characters strong call divergence typically indicative species level differences whereas call similarities two populations evidence taxonomic conclusions especially drawn general call structure two candidate species different qualitative call differences thus observed hand quantitative differences call traits substantially vary within among populations require careful evaluation analysis provide guidelines taxonomic interpretation call differences situations emphasize need integrative use multiple datasets bio morphology genetics particularly scenarios show small sized often calls frequency components ultrasound spectrum although unlikely high frequencies biological relevance majority illustrate detection upper harmonics depends also recording distance higher frequencies attenuated strongly remains prime approach integrative taxonomy uncertainty due possible variation technical artifacts adequately considered acknowledged
engineering whether form product development manufacturing processes often drives selection creation new materials order meet performance requirements conversely development new materials new ways process materials lead new engineering capabilities turn lead new products improved product performance interplay materials engineering dynamic ongoing critical success many new products industries article take examples interplay four technology companies different industries developing widely different materials systems example demonstrates critical role materials play creating new products new manufacturing methods even new design methodologies examples come polymer microfluidic devices silicon based systems metals additive manufacturing
mechanical vibrations therapy widely used non conservative safe physical method patients diagnosed osteoporosis postmenopausal women training also athletes recovery rehabilitation phase paper main goal assessing effects whole body vibration therapy applied professional complementary alternative training improve sport performance quality life experiment applied group ten volunteers athletes university ages years appropriate weight height signed statement self agreement participate study trial performed via proper dynamic vibration installation two months subjects bed upper limbs inferior limbs extended provide support spine fixed support installation comprised vibration bed direct control vibration signal electronic analyzing system acquisition interpretation vibration data allowing control rotation frequency alarm safety system visualization line measurement process electric motor bed generate predictable vibration values three axes used two types tri axial vibration sensors one accelerometer fixed bed second implant accelerometer anterior face evaluated subject mechanical vibration training session performed frequency minutes consisted eight series seconds one minute breaks evaluation data made assessing values subjects recorded initial stage final therapy supposed control objective parameters standing long jump standing high jump intensity exercise performed physical efforts results vibration trial stressed subjects significant increase sport performances vibration training parameter assessing means viable alternative method used improve athletic performance quality life
paper suggest hierarchical control scheme applicable engine control chosen setup facilitates simultaneous control emissions torque top level standard pid controller installed setting injection quantity order reach demand torque prerequisite follow given load profile second level dedicated emission control apply dynamic matrix control specific form model predictive control stands simple way modeling controlled process represented step responses constraints absolute values maximum rates change applied system inputs cope given hardware limitations moreover incorporate called operational constraints thus input variables certain operating regions thereby areas high emissions excluded advance furthermore include predefined demand torque input known impact transient torque changes emissions act optimal way respect given load profile cope nonlinearities combustion engine apply network several scheduled engine speed load actuators also propose procedure reduce amount modeling data introducing parameterized formulation measured step responses proposed control concept evaluated realistic physically based engine model several representative driving sequences amongst known new european driving cycle highly dynamic worldwide light duty test cycle advantages conventional pid control finally summarized demonstrated typical load step
paper presents experimental study laboratory tests conducted investigate different pavement surface bases improve performances vibration response anti erosion bases tests vibration response bases geotextile rubber sheet used micro seismic testing system employed characterize vibration response bases concrete different impact loading vibration test results indicated impact loading compared bases without vector sum maximum vibration velocity bases rubber sheet two layers geotextile decreased respectively vector sum maximum vibration displacement decreased respectively laboratory tests anti erosion bases geotextile asphalt tested performances water erosion via self made testing apparatus anti erosion test results indicated conditions compared bases without erosion rate min testing bases geotextile asphalt decreased respectively effects damping vibration water erosion pavement base
advances information communication technologies ict virtual education bringing new tools market provide virtual solutions range problems nevertheless experimentation using computer aided control system design tools still fundamental future engineers paper describes control course laboratory element designed teach electronic control engineering students use networked control system drive electric car prototype multidisciplinary nature laboratory allows students take advantage previous academic training model plant open loop test contrast simulated behavior experimental results obtained prototype goal work students across multiple engineering disciplines able integrate knowledge acquired throughout degree studies evaluation students grades perception course conducted confirmed educational benefits approach
background strongly associated obsessive compulsive disorder cognitive behavioural therapy cbt found result reductions range symptoms individuals anxiety disorders depression eating disorders aim pilot test efficacy group cbt participants elevated method participants randomized receive immediate week group cbt week followed cbt results reliable reductions large effect size indicated cbt associated improvements severity post test however changes clinically significant drop high resulting small final sample conclusions cbt effective reducing disorder specific symptoms however high drop rate lack clinically significant findings suggest research needs conducted determine efficacy cbt
paper propose workflow detect track cells time microscopy image sequences order avoid requirement cell lines expressing fluorescent markers associated phase contrast microscopy often preferred fluorescence microscopy live cell imaging however common specific image characteristics complicate image processing impede use standard methods nevertheless automated analysis desirable due manual analysis subjective biased extremely time consuming large data sets present following workflow based mathematical imaging methods first step detection performed means circular transform obtained circular contour subsequently serves tracking algorithm based variational methods sub divided two parts order determine beginning whole cycle tracking procedure performed cell tracked time end result average duration ratios different cell cell death division division two cells measured statistics cell morphologies obtained tools featured matlab graphical user interface authors published elsevier inc
selective laser sintering technology directly manufacturing complex structure however due limitation manufacturing engineering factor surface quality dimension accuracy green part still outstanding problem experimental methods adopted study effect part orientation machining accuracy part orientation significantly affects outline part due stepping phenomenon affects surface quality dimension accuracy experimental samples different part orientations including degree fabricated results indicated stepping phenomenon significantly affected part orientation part orientation degree dimension accuracy best part orientation mean stepping phenomenon smallest part structure complicated important structure dimension chosen orientation degree
work devoted investigate process electrochemical deposition solution presence acid aqueous media kinetics mechanism process electrode surface studied proposed aid cyclic linear characterization methods found process affected presence acid factors electro reduction process results also show temperature potential rate concentration great influence achievement process important parameters calculated activation energy electrochemical reaction diffusion coefficient number saturated sites film examined using diffraction scanning electron microscopy energy dispersive spectroscopy elsevier rights reserved
member transcriptional subtype cyclin dependent kinases family shows remarkable cancer tissue specific expression profile rather selective contribution regulation gene expression levels involved signaling pathways however effect malignant phenotype human laryngeal squamous cell carcinoma cells potential molecular mechanisms remain unclear present study evaluated expression levels quantitative real time reverse transcriptase polymerase chain reaction qrt pcr immunohistochemistry tissue samples patients analyzed correlated results clinicopathological features demonstrated significantly overexpressed tissues compared normal controls overexpression correlated lymph node metastasis advanced clinical stages kaplan meier analysis showed high expression levels mirna significantly correlated short survival addition regulation using small interfering rna sirna reduced proliferation migration vitro explore potential mechanism investigated effect wnt signaling pathway found involved emt progress regulating beta catenin wnt signaling summary data suggest first time appears contribute malignant mechanism represent significant prognostic marker patients
objective help clarify effect gender bidirectional relationship alcohol use physical activity college students participants five hundred twenty four female college students recruited august followed april april respectively methods participants reported alcohol use physical activity occasions baseline follow approximately apart results females alcohol use quantity baseline associated increased physical activity year follow ups alcohol use frequency baseline associated decreased physical activity year follow males alcohol use frequency baseline predicted decreased physical activity year follow conclusions gender differences explained eating disorders perspective women use physical activity compensatory strategy combat potential weight gain consumed alcohol use
background epigenetic mechanisms provide interface environmental factors genome known play role complex diseases obesity mechanisms including dna methylation influence regulation development differentiation establishment cellular identity employ two approaches identify differential methylation two white adipose tissue obese individuals gastric bypass significant weight loss analyse genome wide dna methylation data using traditional paired tests identify significantly differentially methylated loci bonferroni adjusted observed changes dna methylation subcutaneous adipose changes clinical trait particular cpg sites within fasting glucose four cpg sites within hdl single cpg site gave strong tissue separation validation independent subcutaneous adipose samples conclusions first study report genome wide dna comparison subcutaneous abdominal adipose weight loss combinatorial approach utilised powerful tool identification methylation loci strongly differentiate tissues study provides solid basis future research focused development adipose tissue potential dysfunction obesity role dna methylation plays processes
levonorgestrel lng dedicated emergency contraception product available counter china although lng considered effects developing fetus contraceptive fails pregnancy occurs studies specifically examining issue purpose study compare physical mental development children born lng failure cohort children born mothers history exposure lng substances group children exposed lng mothers conception cycle study group matched group children without exposure lng control group physical mental development children evaluated compared period four congenital malformations study group three control group respectively follow period statistically significant differences two groups respect childrens weight height head circumference intelligence scores values parameters groups similar national standards summary lng effect physical growth mental development occurrence birth defects children born pregnancies failed
growth large scale data management capabilities successful care patients congenital heart defects last three decades participation multicenter congenital heart disease databases registries now fundamental component cardiac care manuscript attempts first time one location relevant databases worldwide including target populations web sites participation information since least cardiac surgeons began leveraging technology create multi institutional data collections addressing variety within field pediatric heart diseases particularly suited methodology individual care location access relatively limited number diagnoses procedures given year combining multiple institutions data therefore allows far accurate assessment treatment modalities adverse outcomes additionally data used develop outcome benchmarks individual institutions measure progress field whole focus quality improvement efforts directed fashion increasing utilization combining clinical research efforts within existing data structures efforts ongoing support better collaboration integration across data sets improve efficiency utility data collection infrastructure information collected enhance return investment participating institutions
data wide field helpful secure network communications common many data researchers consider improving increasing many aspects capacity file quality robustness paper use audio file cover propose reversible method modifying sample values using modulus function order make particular value secret bit needed embedded addition use location map modified sample values reversible data needs exactly recover secret message original audio file file experimental results show method measured correlation algorithm able retrieve exactly secret message audio file moreover made significant improvement terms following capacity since sample value carrying secret bit quality measured peak signal noise ratio signal noise ratio snr pearson correlation coefficient similarity index modulation proven quality audio relatively high
objective explore validity assessment tool development emotional stories test measure designed assess ability people traumatic brain injury tbi make inferences emotional state others solely contextual cues methods procedures study stories presented healthy young adults data two versions created study version administered group participants moderate severe tbi group participants group participants participants also completed facial affect recognition test participants facial affect recognition impairment returned weeks later administered tests main outcomes participants tbi scored significantly lower healthy group mean scores group significantly lower group scores significantly correlated scores test test reliability scores adequate conclusions versions found sensitive deficits emotional development provide clinicians valuable information intervention planning
study examined whether sleep disturbance predicted moderated responses psychotherapy participants participated step national study examined effectiveness different treatment combinations bipolar disorder participants received either brief psychosocial intervention called collaborative care intensive psychotherapy study based pharmacotherapy participants defined current past week short hours night according reported average sleep duration week randomization sleep disturbances predict likelihood recovery time recovery depressive episode difference recovery rates versus normal medium effect sizes observed differences short long study sleep play major role predicting moderating response psychotherapy bipolar disorder
purpose paper analyze dynamic characteristics proposed digital peak current mode converter waveforms output voltage reactor current derived small signal analysis compared simulation results assuming actual large amplitude operation confirmed tendency transient response indicated based analysis results experimental result proposed method shows validity proposed method gradual response obtained improvement stability converter consequently proposed method solution implementing peak current mode control digital
although alzheimers disease criteria promote use biomarkers maturity clinical routine still needs assessed light oncology framework conducted literature review measures used assess delayed recall impairment due medial temporal lobe dysfunction free word list recall tests ample evidence available phases rationale use discriminative ability early detection ability many tests routine use evidence phase performance real world phase quantify impact costs yet come administration procedures standardized cutoff scores validated large alzheimers disease mild cognitive impaired series aspects different task formats however results among different populations reproducibility laboratories definite guideline use thus proposed moment accordingly maturity markers yet sufficient requires future investigation promote proper use memory measures clinical settings elsevier inc rights reserved
last years research activities regarding software environmental impacts find way field green thus researchers became aware fact software one drivers energy consumption ict however awareness aspects much higher especially non scientific area one side software developers aware green strategies software engineering side using products need responded effects using ict products onto environment one idea transfer environmental effects software social issue create eco label software products next defining criteria label laid methods evaluate software products seems helpful identify aspects influencing acceptance certification green software products context acceptance means taking eco label account searching new software hence following paper aims identifying aspects applying technology acceptance model specific case labelling green software products present first version acceptance model label green software products still work progress needs evaluated next step generally aim create tool used develop eco label software products strongly accepted
numerous studies shown exposure media violence increases aggression though mechanisms effect remained elusive one theory repeated exposure media violence viewers real world violence increasing aggression reactions violence removing normal aggression theoretically violence desensitization reflected amplitude component event related brain potential erp associated activation motivational system current study violent images elicited reduced amplitudes among violent compared video game players additionally reduced brain response predicted increased aggressive behavior later task moreover effects held controlling individual differences trait aggressiveness data first link media violence exposure aggressive behavior brain processes associated desensitization elsevier inc rights reserved
big temperature rising principle problem application permanent magnet synchronous motors high power density electric electric paper proposed novel conception hybrid temperature control method using phase change material permanent magnet synchronous motors design models hybrid cooling cylinder shape developed prototype case optimized paraffin phase change material built set experimental equipment constructed verify thermal managing performance hybrid cooling method impacts different heat loads various working duty cycles cooling effectiveness analyzed experimentally results indicate hybrid temperature control method performs extending duration work time decreasing temperature rising motor design models developed paper suitable designing parallel systems elsevier inc rights reserved
purpose previous studies primarily assumed dysfunctional effects cultural distance joint paper positive organizational scholarship perspective perceived cultural distance advance firms new product development within non equity purpose paper explain perceived cultural distance stimulates task discourse supports alliance partners employees recognizing applying culture related differences complementary problem solving potentials due lower integration level non equity compared joint paper assumes positive effects negative effects cultural distance design methodology approach study applies structural equation modeling test hypothesized effects sample international manufacturing industry findings analysis mainly supports hypothesized model positive effects emerge perceived cultural distance practical implications findings provide managerial implications alliance managers note cultural distance positive negative effects thus barrier per firms benefit cultural distance able leverage culture specific task discourse among partners originality value manuscript uses unique data set international global manufacturing industry manuscript published elsewhere
classical cipher generally believed resistant attack paper using divide technique first shown key matrix broken computational complexity english language much less publicly known attack force complexity using chinese theorem shown computational complexity proposed attack reduced using information theoretic approach shown minimum length required successful attack increases factor respectively two attacks comparison force attack serious attack since elsevier rights reserved
batch processes great importance process industry however control algorithm design difficult constraints stability recursive feasibility along directions time batch guaranteed simultaneously paper stable model predictive control strategy zero terminal state constraints proposed stability recursive feasibility along two directions guaranteed proved simulation results given show effectiveness algorithm ifac international federation automatic control hosting elsevier ltd rights reserved
background quantified impact lifestyle dietary modifications chronic kidney disease ckd estimating population attributable fractions study design observational cohort study setting participants middle aged adults type diabetes without severe ongoing alone combination global endpoint trial factors modifiable lifestyle dietary risk factors physical activity size social network alcohol intake tobacco use diet intake various food items outcomes primary outcome ckd ascertained moderate severe annual decline estimated glomerular filtration rate egfr years competing risk death considered defined proportional reduction ckd mortality within years occur exposure risk factor changed optimal level results baseline median urinary albumin creatinine ratio egfr iqr mmol iqr min respectively years participants developed died physically active every day ckd death among food items increasing vegetable intake largest impact population health considering diet weight physical activity tobacco use size social network exposure less optimum levels gives ckd death million middle aged americans diabetes improving lifestyle behaviors optimal range reduce incidence progression ckd years number deaths within years limitations changes kidney measures precisely match definitions incidence progression ckd conclusions healthy lifestyle diet associated less ckd mortality substantial impact population kidney health kidney authors published elsevier behalf national kidney foundation inc open access article license
little known virulence human pathogen varies environment shares vector study focused whether virulence causal agent disease related altitude accordingly specimens collected three different mexico parasite isolated infect uninfected female mice response variables activity key insect immune response mice numbers heart brain rodents highest levels activity found isolates particularly mouse brain polymerase chain reaction based analysis indicated isolates belonged lineage thus dangerous sources altitude common apparently conditions beneficial development control strategies focus activity around least relation region present study sites
paper present framework managing qualitative spatiotemporal patterns framework designed large scale monitoring systems systems generate huge amount real time data various formats end users interested finding significant data configurations based expertise attempt leverage large amounts data generated acquisition systems several software tools proposed help users achieve goals however available solutions mostly based relational databases use sql queries support functionalities systems allow real time detection situations interest also called patterns domain due weak sql queries present novel approach based complex event processing real time detection situations interest based events states spatial objects leverage rich semantics qualitative pattern representation model present complete solution qualitatively represent patterns detect instances event cloud thanks approach user able react detected patterns instead trying identify mine patterns databases proposed current approaches
purpose bradykinin receptor antagonist approved treat acute hereditary angioedema attacks adults date thorough investigation clinical pharmacokinetic parameters primary metabolites reported present results two phase clinical studies healthy human volunteers methods single multiple dose plasma pharmacokinetics characterized healthy volunteers concentration time profiles parameters derived single dose three doses given hour intervals results maximal plasma concentrations doses achieved hour total plasma exposure doses respectively elimination half life values hours respectively conclusions single subcutaneous administration exhibited dose proportional accumulation upon repeated doses administered hour intervals
influenza virus infection causes acute highly respiratory illness triggers cell death infected cells airway epithelial destruction key regulator cell death responses growing number viral microbial agents study aimed investigate role inflammation influenza virus infection knock mice wild type mice infected influenza virus determine contribution inflammatory response influenza virus infection found mice infected virus showed higher survival less weight loss compared wild type mice addition mice fewer regions edema infiltration inflammatory cells beta significantly decreased days compared mice moreover caspase beta signaling found associated influenza virus dependent necrosis conclusion results indicated deficiency protect mice infection influenza virus caspase beta signaling provided independent manner
paper describes improved parallel mpi based implementation variable block variant proposed solving general linear systems parallel solver detect automatically exact approximate dense structures linear system exploits information achieve improved reliability increased throughput factorization novel graph compression algorithm discussed finds approximate dense blocks structures requires one simple use parameter complete study numerical parallel performance parallel presented analysis large turbulent navier stokes equations suite three dimensional test cases elsevier rights reserved
context technical describes effect immature artifacts software maintenance bring short term benefit project terms increased productivity lower cost paid interest later much research performed propose mechanisms identify decide appropriate moment pay important investigate current state art order provide researchers practitioners information enables research activities technical management practice objective paper following goals characterize types technical identify indicators used find technical identify management strategies understand maturity level proposal identify visualization techniques proposed support technical identification management activities method systematic mapping study performed based set three research questions total studies evaluated results proposed initial taxonomy technical types created list indicators proposed identify technical identified existing management strategies analyzed current state art technical identifying topics new research efforts conclusion results mapping study help identify points still require investigation technical research elsevier rights reserved
debate representation brain nature cognitive system going decades now paper examines neurophysiological evidence primarily single cell recordings get better perspective issues initial review basic concepts paper reviews data single cell recordings cortical columns category selective neurons neuroscience columns cortical columns understood basic functional computational unit paper reviews fundamental discoveries organization finds reveals massively parallel search mechanism organization extensive neurophysiological evidence widespread use representation brain paper also reviews studies category selective cells evidence category selective cells reveals representation also used encode complex abstract concepts highest levels processing brain third major issue nature cognitive system brain whether form purely abstract encoded single cells provide evidence single cell based purely abstract cognitive system paper reviews findings related cells appears widespread usage cells brain areas sensory processing takes place plus evidence abstract modality invariant cells higher levels cortical processing overall reveals existence purely abstract cognitive system brain paper also argues since evidence dense distributed representation since sparse representation actually used encode memories actually evidence distributed representation brain overall appears abstract level brain massively parallel distributed computing system symbolic paper also explains grounded cognition theories brain fully compatible representation purely abstract cognitive system
measurement bone strain key factor bone biology studies understand changes structure bone mass helpful improvement treatment process patients suffered due bone diseases system design bone strain requires components include sensors amplifiers analog digital converters adc filter processing unit whenever bone loaded creates small adjustment bone mass measurement bone strain system requires accuracy minimum variation structure bone mass strain gauge sensors used sense change interconnected plates bone mass strain strain minimum value range processed get original value strain processing signal easier digital signal compared analog signal hence voltage signal sensor measuring strain transmitted transmitted signal amplified operational amplifier analog signal converted digital using comparator circuit operational amplifier comparator circuit designed using complementary metal oxide semiconductor cmos technology reduce power consumption simulated help graphics system takes long time measure strain system power consumption low thus analysis strain useful treatment orthopedic diseases
objective investigate association perception expressed emotion psychopathology school going adolescents non clinical sample methods cross sectional field study conducted turkey comprised high school students school years data collected using information collection form strengths difficulties questionnaire shortened level expressed emotion scale spss used data analysis results subjects girls boys overall median age inter quartile range years significant positive relationships scales terms emotional problems behavioural problems attention deficit hyperactivity disorder peer relationship problems also negative significant relationship pro social behaviours expressed emotion conclusion concept perceived expressed emotion non clinical adolescents useful clinicians preventing mental disorders
restoration streams returning coarse sediment stream edges channel become common practice sweden yet restoration activities always result return desired study evaluated restoration project river northern sweden practitioners increased channel complexity previously restored stream reaches placing large trees gravel adjacent areas channels one reach restored basic methods another enhanced methods selected ten different main channel hydraulic complexity enhanced chemical composition soils communities plants fish exhibit clear responses enhanced restoration measures first years compared reaches restored basic restoration methods variation collected data among streams instead types restored reaches conclude restoration disturbance immigration potential varies across landscapes biotic recovery processes river systems slow suggest enhanced restoration apply catchment scale approach accounting connectivity availability source populations low intensity monitoring performed several decades evaluate restoration outcomes
changes child abuse related fractures difficult distinguish therefore important follow standardized procedure order detect mineralization defects skeleton differentiate healing fractures present typical post mortem case year old boy different diagnostic tools applied confirm condition autopsy seen vitamin insufficiency found laboratory analyses radiography accumulation non bone histological preparations led correct diagnosis case shows appropriate methodology use bone preparations paramount importance detect mineralization defects moreover case involved combination child abuse situation often complex neglect abuse lead vitamin insufficiency
background people multiple sclerosis high risk osteoporosis fractures poor vitamin status risk factor vitamin supplementation recommended prevent progression maintain bone health methods assessed effect vitamin weekly compared placebo biochemical markers bone metabolism persons relapsing remitting multiple sclerosis results serum levels doubled vitamin group parathyroid hormone decreased vitamin group compared placebo group week week however effect bone formation measured type bone resorption measured terminal cross linking type collagen neither predicted bone loss baseline week conclusions findings corroborate previously reported lack effect weekly high dose vitamin supplementation bone mass density patients suggest vitamin supplementation prevent bone loss persons vitamin deficient
work extended version eds international workshop coding cryptography proposed first code based group signature new group signature scheme present numerous advantages existing post quantum constructions even terms properties pairing based constructions allows add new members lifetime group dynamic plus appears scheme extended signature according definition eds advances model handling membership security based relaxation model topics model verifying properties non main idea scheme consists building offset collision two syndromes associated two different matrices random one enables build random syndrome chosen small weight vector matrix syndrome decoding problem permits find small weight previous random syndrome fixed syndrome added two small weight vectors constitute group members secret key whose knowledge proved thanks variation authentication protocol applications consider case code based signature scheme advances one number group members leads signatures public keys sizes along work also introduce new kind proof knowledge weak zero knowledge implicitly covered short version paper eds international workshop coding cryptography appear particularly fitted context group signature schemes allows test whether specific used without learning proof random oracle model ensure security scheme defining one syndrome decoding problem new code based problem related syndrome decoding problem ieee trans theory
essay analyzes link mobilization developed exposed structure deeply complex network deployed support generate behavior achieve advantageous strategy position fight although description supports society model rules movement restored network hardly explored counter value opportunity essay therefore draws narratives analyze properties culture identity problem solving non linear social network demonstrates paradigm mobilization valid indicator security link mobilization therefore develops intervene social life address security locally
objective research crime mentally focused middle aged cohorts long standing illness functional disability rates correlates young cohorts largely unknown methods participants aged years attending centres australia clinical interview provided self reported data regarding lifetime results quarter sample reported crime including experienced violent mainly physical sexual assault non violent crime forms associated illicit substance use sexual orientation young adult age male gender specifically associated non violent participants reported violent significantly impaired functionally clinically reporting non violent conclusions young people mental health vulnerable criminal particularly violent although lifetime rates substantially lower observed older cohorts serious mental illness effective early intervention address modifiable factors reduce risk
much attention given estimating cement related emissions china however scant explicit exploration done regional national emission volumes aim work therefore provide improved bottom spatial integration system relevant emissions factory level allow accurate estimation emissions cement production based system sampling data cement production lines integrated regional national level information integration results showed produced process fuel electricity emissions accounted respectively volume emissions cement production reached respectively discrepancy identified emission factors relevant two main production processes new suspension pre vertical shaft probably relevant energy efficiency two technologies analysis spatial characteristics indicated spatial distribution emission factors mainly corresponded process discrepancy spatial pattern largely economic population distribution pattern china study fill knowledge gaps provide role players useful spatial integration system facilitate accurate estimation carbon corresponding regional mitigation strategies china
theory methods obtain reduced order models moment matching input output data presented algorithms estimation moments linear nonlinear systems proposed estimates exploited construct families reduced order models models asymptotically match moments unknown system reduced conditions enforce additional properties matching prescribed eigenvalues upon reduced order model provided discussed computational complexity algorithms analyzed use illustrated two examples compute converging reduced order models linear system describing model building provide exploiting approximation moment nonlinear planar reduced order model nonlinear converter author published elsevier ltd
molecular dynamics simulation tension along performed study influence various surface defects initiation plastic deformation fracture gamma single crystals results indicate brittle fracture occurs perfect bulk surfaces edges detrimental strength materials provide dislocation site defects surfaces edges cause various effects depending defect type size position orientation edge influential gamma surface dislocations edge rod small dislocation occurs larger strain rate dependent critical size dislocations upon tension super dislocations vectors containing four effects surface orientation shape sensitive parallel loading direction little influence sharp ones perpendicular loading direction cause crack thus avoided simulation also shows type surface defect lower strength cause crack cases facilitate dislocation improve controlled copyright office journal materials science technology published elsevier limited
days three degree freedom considered backbone industries mostly used placing heavy objects one place another place common part mostly system two main tasks system movement loading payload safety mostly depends upon sub tasks cases number unwanted vibrations due undesirable initial results uneven operation usually happened acceleration start end operation desirable develop control technique tries reduce initial providing reasonable input moreover reduction reduce payload vibrations results smooth operation research work implemented control technique payload vibration position control system three gains controllers found two methods namely pole placement performance controllers investigated matlab simulink results shows effectiveness tune compared tune pole placement context settling time rise time position payload vibrations former technique also helpful reduction payload vibrations payload load anti swing also improved overshoot
provide interesting data perception empathy focus cue validity expanded look cues used whether multimodal properties perception empathy relates first impressions
purpose background although second generation antipsychotics used treat manage symptoms several psychiatric disorders data adverse effects developmental age limited prospective observational study verify cardiovascular metabolic risk sample antipsychotic naive children adolescent patients starting therapy methods twenty two patients younger years recruited assessment included anthropometric data cardiovascular parameters blood tests abdominal study results average follow period months statistically significant increases mean values waist circumference body mass index bmi bmi percentile bmi score total cholesterol prolactin found cardiometabolic parameters showed upward trend time subjects stage female patients susceptible developing cardiometabolic changes moreover significant correlations changes anthropometric several metabolic parameters found tendency change liver distribution abdominal fat mass abdominal study also evident conclusions sample several metabolic parameters showed sensitivity treatment parameters age dependent metabolic syndrome criteria used adults inappropriate children adolescents periodic clinical instrumental evaluations guidelines monitoring metabolic laboratory instrumental complications necessary perspective even long time second generation antipsychotics treatment children adolescents
background possible relationship periodontitis juvenile idiopathic arthritis now mostly unknown common characteristics two diseases purpose study evaluate etanercept effects periodontal conditions children affected methods study three group patients selected first one represented subjects pharmacologic therapy etanercept second one composed subjects pharmacologic therapy drugs third one healthy subjects twenty subjects group selected subject two periodontal scores taken plaque index bleeding probing order check reliability method second registration performed groups one month statistic test performed results average plaque index first group second group control group average bleeding index first group second group control group conclusions etanercept seems reduce periodontal inflammation children affected therapy
enormous growth industrial applications using internet communication secure network prime objective survival organization network monitoring defence systems become integral part network security identifying preventing potential attacks intrusion detection prevention systems network based defence systems combines intrusion detection system ids contrast ids proactive technique provides quick reactions potential threats attacks network preventing attacks entering network current generation limitations performance effectiveness studies proven modern difficulties dealing high speed network traffic meeting current network requirements exist several research approaches find efficient nevertheless serious security privacy still occur every day creating absolute necessity provide secure safe information security systems survey provides date comprehensive review state art based different accelerating techniques different detection algorithms types hardware optimizing algorithms match demand requirements high speed network detailed overview high performance ids along pros individual techniques given paper also highlights discusses requirement developing new detect known unknown threats
traditional visual secret sharing scheme encodes secret binary image shares random pattern shares printed onto secret image visually revealed subset stacked together otherwise revealed progressive visual secret sharing also allows decryption secret image physical clarity contrast secret image increased progressively number stacked shares existing researches suffer common problems like space pixel expansion noise like shares paper proposes novel scheme four number space efficient meaningful shares achieve efficient preprocessing approach basis matrix creation algorithm also proposed paper also addresses many encryption limitations like explicit requirement restriction number shares etc experiments show contrast reconstructed secret image easily human visual system without cryptographic computation
objectivesto determine cross sectional association cerebral amyloid beta deposition gait sectional based cohort study county normal individuals aged years enrolled clinic study aging concurrent pet imaging gait assessment participants history stroke parkinsons disease traumatic brain injury normal pressure excluded pet measured prefrontal orbitofrontal parietal temporal anterior cingulate posterior cingulate motor specific regions interest gait parameters speed cadence length double support time intra individual stance time variability measured using instrumentation linear regression models adjusted age sex body mass index education apoe epsilon allele comorbidity index depression secondary analyses additionally adjusted neurodegeneration hippocampal volume fdg pet cortical thickness associated regions fully adjusted models including neuroimaging measures neurodegeneration higher pet across associated slower gait speed except parietal roi lower cadence longer double support time except motor roi greater stance time variability sex stratified analyses association higher pet across measures gait present among women pet across independent general measures associated neurodegeneration associated poorer performance multiple gait parameters among cognitively normal women aged years longitudinal studies needed determine whether predicts gait decline women men
patients already taking blood pressure lowering therapy hospital admission acute stroke individual patient data meta analysis randomized controlled trials undertaken determine effect continuation versus temporarily stopping preexisting medication acute stroke key databases searched trials following inclusion criteria randomized design stroke onset hours investigating effect continuation versus stopping medication follow weeks two randomized controlled trials identified included meta analysis individual patient data patients hours acute stroke risk bias study low adjusted logistic regression multiple regression analyses using random effects found significant association continuation therapy versus stopping risk death dependency final follow odds ratio confidence interval significant associations found continuation versus stopping therapy secondary outcomes final follow analyses death dependency subgroups revealed significant associations continuation versus temporarily stopping therapy exception patients randomized hours difference favoring stopping treatment met statistical significance found significant benefit continuation treatment acute stroke period therefore urgency preexisting therapy first hours days stroke unless indicated comorbid conditions
two dimensional incompressible equations model fluids play important role study convection mathematically system key features navier stokes euler equations vortex stretching mechanism issue whether equations always possess global time classical solutions difficult partial dissipation dissipation paper obtains global regularity two partial dissipation cases proves several global priori bounds two prominent partial dissipation cases results take one step closer complete resolution global regularity issue partial dissipation cases involving equations elsevier inc rights reserved
background childhood cancer survivors risk recurrence primary cancer secondary site cancers survivors also increased risk long term effects chronic illnesses health promoting lifestyles therefore especially important childhood cancer survivors purpose study describe health promoting behaviors childhood cancer survivors determine whether behaviors associated demographic clinical characteristics descriptive comparative study took place oncology follow clinic sample seventy seven childhood cancer survivors tools health promoting lifestyle profile questionnaire interpersonal relationships spiritual growth physical activity nutrition health responsibility stress management smoking alcohol consumption demographic clinical questionnaire mean item score moderate high survivors scored highest interpersonal relationships spiritual growth lowest scoring activities physical activity nutrition survivors smoking alcohol consumption women opposed men likely higher scores related nutrition interpersonal relationships opposed married found higher scores related spiritual growth conclusions health behaviors associated interpersonal relationships spiritual growth likely performed compared physical activity good nutrition decreased smoking alcohol consumption special attention placed promoting physical activity good nutrition among survivors childhood cancer
article presents new method optimally partition geometric domain capacity constraints partitioned regions important problem many fields ranging engineering economics known capacity constrained partition obtained power diagram squared metric present method super linear convergence computing optimal partition capacity constraints outperforms state art order magnitude demonstrate efficiency method context three different applications computer graphics geometric processing displacement interpolation function distribution blue noise point sampling optimal convex decomposition domains furthermore proposed method extended capacity constrained optimal partition respect general cost functions beyond squared euclidean distance
laid rich foundation understanding concept emotion derived prominent physiology psychology classic conditioning conditioning respectively framework guided interest motivation general interaction reward stress began john thesis work guidance among many others using study neurobiology addiction framework argue drug addiction involves positive reinforcement associated effects drugs abuse also involves another major source reinforcement specifically negative reinforcement driven negative emotional states termed dark side addiction excessive activation brain reward systems leads decrease function normal reward related persistent recruitment brain stress systems linked understanding comprises negative reinforcement associated addiction key understanding negative emotional states general pathophysiology
fully take advantage external charging conditions reduce fuel consumption extended range electric vehicles charging management based intelligent control strategy proposed intelligent control strategy applied different driving patterns based various characteristics urban roads vehicle driving arterial roads constant power control strategy applied driver charging station time determined based current state vehicle distance charging station vehicle driving power follower control strategy applied range engine controlled work wide variety regions obtain optimum fuel economy simulation results indicate vehicle charging station proposed charging management based intelligent control strategy made state charge reach lowest level driver made decision charge charging station therefore driver charge vehicle much clean electric energy possible charging station
paper velocity tracking controller drive transmissions developed solution based state dependent model incorporates nonlinear characteristics system full state feedback controller devised gains scheduled measured speed pressures together approximated volumetric flow effects uncertainties especially related equilibrium values pressures eliminated utilizing called implementation technique eliminates need equilibrium values model based thus uncertain demonstrate efficacy controller solution implemented wheel comparison purposes constant gain state feedback controller integral action devised also linear pid controller tuned results show benefits devised controller significant compared two controllers moreover controllability machine maintained every situation
deep solvents recently potential alternatives ionic liquids although possess core characteristics similar low volatility non low melting points low vapor pressure nature chemical thermal stability high solubility superior terms availability raw materials ease storage synthesis low cost starting materials become subject intensive research various sectors notably chemical electrochemical biological sectors date applications shown great promise especially medical biotechnological fields spite various achievements safety concern mixtures sufficiently addressed indeed order exploit vast array opportunities offer biological industry first established safe mixtures hence biotechnological applications implemented proven negligible low toxicity profiles review first kind discusses two current aspects des based research first describes properties mixtures ample focus toxicity profiles second provides overview occurred prospects use various biotechnological biological applications elsevier inc rights reserved
problem synchronous fractional sample rate conversion digital signal based novel approach two different efficient causal block implementations concurrently derived compared computational load structures performed mimo subsystem rate identical group delay always different column row shifts matrix representation mimo subsystem possible transform structure arbitrary implementation changed group delay moreover shown structural manipulation signal flow graph mimo subsystem implementations ultimately require amount computation storage spite different group delay finally using filters maximum number input samples retained output elsevier science rights reserved
refers delay task decision often failure self regulation recent research suggested delineated two domains intentional two study paper aimed develop measure named scale ups test whether stronger marker psychopathology intentional general study community sample participants completed questionnaire consisted several items pertaining derived theory previous research clinical experience responses subjected principle components analysis assessment internal consistency study community sample participants completed newly developed scale along measures general intentional negative affect data ups subjected confirmatory factor analysis revised accordingly ups validated using correlation regression analyses six item ups possesses construct divergent validity good internal consistency ups appears stronger marker psychopathology pre existing measures used study results regression models suggest negative affect differentiate general intentional ups brief good psychometric properties strong associations negative affect suggesting value research clinical tool
peptide major histocompatibility complex enable detection characterization isolation antigen specific cell subsets single cell level via flow cytometry fluorescence microscopy labeling reagents exploit scaffold increase individually weak cell receptor tcr interactions improvement original based technology improving sensitivity rare low cells including self tumor reactive clones however commercial expensive house production involved typical biology research laboratory present simple inexpensive protocol preparing doping conventional preparation use identify patient derived tumor reactive cells apply doping technique prepare tcr use novel reagents yield new insight mhc mediated antigen presentation
background periodontitis genetics smoking play important roles host immune system response aim study determine whether genetic background initial periodontitis detected using active matrix metalloproteinase test finnish adolescents methods forty seven participants gave approval analysis oral fluid collection dna test performed participants adolescents aged years full mouth clinical parameters oral health assessed including periodontal oral mucosal status eastern finland dna extracted oral fluid samples genotyped polymorphisms candidate genes periodontitis results analyzed using logistic regression model values corrected multiple testing using false discovery rate associated vitamin receptor respectively none single nucleotide polymorphisms studied showed significant association test least one lesion positivity conclusion genetic polymorphisms linked initial periodontitis finnish adolescents test eventually detect initial periodontitis young patients predisposing genetic background
recent years natural ventilation technology extensively used order improve indoor environment quality reduce power consumption air conditioning systems green buildings however effect natural ventilation needs evaluated carefully make energy saving buildings safe topic worth studying study uses fire dynamics simulator fire safety enhancement measures existing green building without installation smoke exhaust system since building located school campus require smoke exhaust system according taiwan fire regulations results obtained series improvement strategies tested show natural ventilation generate comfortable air flow unfortunately due stack effect hot air fatal smoke route area behind room fire occurs findings showed two feasible improvement measures controlling state air inlet setting exhaust port room effectively resolve fire safety issues construction undertaken reasonable cost
become serious worldwide mental health problem including asian countries suicidal ideation happens prior actual suicidal behaviour thus identifying roots suicidal ideation vital study investigated relationships parental self efficacy suicidal ideation among adolescents malaysia mediation effect self efficacy relationship parental suicidal ideation also examined total school going adolescents aged old recruited via multistage cluster sampling bivariate analysis conducted using pearsons correlation analysis mediation model tested using spss macro developed resultsthe results showed mother father self efficacy significant negative correlation suicidal ideation specifically self efficacy emerged partial mediator relation mother suicidal ideation self efficacy also fully mediated relationship father suicidal ideation conclusionsthe findings implied mother stronger correlation adolescents suicidal ideation compared father self efficacy plays important role relationship parental suicidal ideation prevention intervention efforts practitioners dealing adolescents mental health issues specifically suicidal ideation seriously consider providing skills enhance mother adolescent relationship self efficacy
common mode differential mode crucial networks modeling filter design particular paper propose original analytical model common mode differential mode input converter including major elements model synthesized using basic laws electrical circuits analysis converter circuit achieved switching function modeling nonlinear behavior assess model performance pspice online simulations common mode differential mode input achieved devices operating results obtained agree analytical model wide regulation frequency range furthermore carried online experimental test bench means capacitive injection technique results obtained confirm validity analytical model highlight impedance switching effect offline measurement also conducted using impedance analyzer
mutations seem negative prognostic impact patients several myeloid neoplasms including myelofibrosis aim work determine prevalence profile mutations methodswe analyzed mutations consecutive patients spanish hospitals means sanger sequencing calr mpl mutations mutations found cases commonly mutations mutations wild type patients least one single nucleotide polymorphism snp triple snp patients overall survival probability patients patients mutations found cases frequent mutations found individual cases previously reported pattern also seen series fifty percent patients combination three specific snps prognostic correlation needs determined larger series
elaborated intrusion theory desire proposes two stage process whereby initial desired target subsequently elaborated mental imagery present study tested whether reduction strategies cognitive guided imagery differentially target intrusion elaboration stages respectively thus differentially impact process participants randomly assigned cognitive guided imagery mind control condition pre post intervention related thoughts thoughts imagery intensity consumption compared experiment recruited general sample young women whereas experiment recruited sample wanted reduce consumption across experiments cognitive lowered thoughts imagery intensity guided imagery reduced related thoughts intensity experiment general sample experiment group differences consumption either experiment results add existing evidence supporting elaborated intrusion theory desire food domain suggest acceptance imagery based techniques potential use problematic elsevier ltd rights reserved
hybrid microbial fuel cell constructed simultaneous utilization solar energy installing next shares cathode microbial fuel cell mfc connecting circuit results enhanced cathode potentials mfc based differences power output characteristics mfc alone improved power production mfc accompanied relatively small decline power density yielding overall enhancement power output
purpose study evaluate possibility early detection pulmonary fungal infections lung scan chronic disease retrospective study patients affected total infectious episodes performed revision clinical data scan analysis treatment performed presence lung nodules evaluated infectious episodes patients total nodules scans identified identification infectious agent biopsy vitro culture resulted positive cases remaining cases received clinical diagnosis suspected pulmonary fungal infection cases introduction empirical antifungal treatment resulted reduction size complete resolution pulmonary lung nodules patients affected lung scan allows early detection pulmonary fungal infection pulmonary nodules single multiple bilateral without sign represent first sign pulmonary fungal infection
infection confirmed clinical cases northeast mexico however bacterium identified infecting vector collected mammals plants northeastern mexico examined eighteen pcr positive rrna genes gene southern blotting probe sequencing genes confirmed infection findings together reports indigenous cases fulfil criteria allow northeastern mexico considered zone endemic disease
advance connections becoming increasingly important requirement many emerging commercial bandwidth scientific computing users however studies area focused scheduling algorithm design addressed implementation challenges larger realistic networking environments particularly result paper develops detailed solution distributed networks novel link state routing extensions update triggering policies introduced exchange inter domain bandwidth state information distributed path scheduling algorithms designed leverage state schedule user requests across domains based upon various traffic engineering policies proposed solutions analyzed detail using network simulation
one worlds significant public health challenges low middle income countries hiv aids deserves treated appropriate medicines however developed screening specific hplc methods analyze antiretroviral medicines major design experiments design space methodology initially applied prediction thanks monte carlo simulations focusing thus using short column low cost organic solvent methanol gradient mode buffer solutions ammonium hydrogen two specific methods dedicated liquid solid dosage formulations also predicted optimized checked ability one method analysis fixed dose combination composed tablet formulations satisfying validation results obtained applying total error approach taking account accuracy profile decision tool validated method applied test two samples coded claimed contain tested assay results satisfying sample elsevier rights reserved
index crucial determining detailed nature propagation electromagnetic waves medium growing demand high resolution measurement index newly synthesized materials usually small optical devices elements miniaturized addition inhomogeneous effects organic materials described mathematical dielectric models essential extract index conventional spectroscopic measurements present novel method called surface extracts complex index material using surface without dielectric models changing length antennas various modes excited coupled target material becomes unique characteristic index since optical parameters extracted wavelength machine learning algorithm mathematical dielectric models necessary furthermore table top fourier transform infrared source detector achieve times enhancement lateral resolution compared conventional owing extreme locality surface normal incidence geometry also successfully demonstrate label free detection protein surface opens exciting new platform
root derived reported many pharmacological activities latest research proven significant osteogenic effect however detail molecular mechanism differentiation fully investigated administration considerably reduced induced bone loss ameliorated reduction plasma levels alkaline phosphatase calcium phosphorus observed mice also deterioration bone trabecular interestingly abundant major pharmacological constituent inhibited receptor activator kappa ligand rankl induced activation kappa erk mapk ultimately osteoclast differentiation induced bone turnover attenuated possibly via repression osteoclast differentiation active component regarded candidate treatment osteoporosis diseases wiley periodicals inc
based research conducted western australia part thesis article looks shifting boundaries gender roles australian households highlights stance biological differences men women basis understanding gender roles responsibilities also ideal influences contemporary gender roles interplay social economic factors impact upon australian households western setting order capture perceptions accounts participants research perceive providing caring roles household unit primary research uses narrative part methodology findings show variance textual contextual women also become providers household shows mainstream australian society also implications gender equality economic empowerment women approached diverse society like australia
heat transfer entropy generation flow water porous vertical nonlinear radiative heat flux investigated numerically combined effects nanoparticle volume fraction hydrodynamic slip magnetic field injection thermal radiation heat transfer entropy generation studied dimensionless governing equations solved numerically applying integration method together technique study accuracy numerical results verified comparing predictions exact solutions model without radiation effects force different previous literature heat transfer subject nonlinear thermal radiation heating viscous dissipation solved analyzed using conjugate convective radiative heat transfer boundary surfaces moreover influences pertinent parameters velocity temperature local global entropy generation number discussed detail illustrated graphically based numerical results proved global entropy generation decreased nanoparticle volume fraction injection reynolds number increased number force intensity radiation parameter conduction radiation parameter addition possible determine optimum values slip flow minimum values global entropy generation rate number also calculated explored different conditions way optimum values number maximum heat transfer heated left plate derived elsevier ltd rights reserved
background improving graft become crucial task graft survival endothelial cells basis new isolated coating demonstrated improve survival however traditional method coating low efficiency vitro study conducted evaluate effect acid scaffold efficiency coating angiogenesis coated graft methods fibrous scaffold used coating culture evaluated efficiency coating graft angiogenesis results vitro experiments found apoptosis index coating group significantly lower control group days culture stimulation index significantly greater group control group day coating vascular endothelial growth factor vegf level group significantly higher coating control group days culture tight adhesive three dimensional growth microenvironment cultured scaffold higher coating efficiency showing stronger staining intensity enzyme control group days culture following coating vivo study scaffold significantly prolonged average survival time coated graft transplantation compared control group days days angiogenesis area survived group compared control group measuring mean density addition expression vegf protein kinase receptor tie gene increased scaffold group control group real time reverse transcription polymerase chain reaction analysis conclusions results demonstrate efficiency coating successfully increased scaffold method enhances function survival isolated vitro vivo
previous research reported serotonin receptor gene polymorphisms associated memory however unknown whether genetic variants associated true false memories current study han chinese subjects tested single nucleotide polymorphisms snps within gene potential associations true false memories false memories assessed using deese roediger mcdermott drm paradigm people remember semantically related words found snps within gene associated true memory associations true memory seven adjacent snps still significant multiple testing corrections haplotype based association analysis revealed true memory positively associated haplotype seven adjacent snps still significant multiple testing correction one snp associated false memory significant multiple testing correction study asian population genetic variation associated episodic memory also suggests association restricted true memory elsevier inc rights reserved
many patients moderate severe subjected surgical therapy due patients implantation therapeutic alternative aim article present recommendations treatment procedure purpose selective literature review carried based current literature notably national international guidelines procedure rehabilitation indicated underlying heart failure treatment heart valve optimization drug therapy implementation standardized heart failure training initiation strength endurance training psychosocial support initiated patients prophylaxis lasting least six months furthermore according current guidelines treatment ace inhibitors beta blockers antagonists optimized special feature anticoagulation currently empirically accounted performed sinus rhythm typically four weeks dual antiplatelet therapy aspirin followed monotherapy aspirin atrial fibrillation lifelong oral anticoagulation indicated combined platelet aggregation inhibitor four weeks particular control rehabilitation clinic focused residual atrial defect gradient residual
inhibitors increase cyclic levels results smooth muscle relaxation determined effects administration hypothalamic pituitary gonadal axis men erectile dysfunction low testosterone levels testosterone erectile dysfunction trial initially administered optimized dose men aged erectile dysfunction low serum total testosterone free testosterone sex steroids measured baseline optimization longitudinal study without separate control group serum testosterone measured using liquid chromatography tandem mass spectrometry administration optimized dose associated mean increases total free testosterone levels respectively accompanied parallel increases serum significant suppression luteinizing hormone change levels suggesting direct effect testicular level increased respectively supporting possible effect adrenal conclusion administration associated increased testosterone levels likely direct effect testis
investigated proposal ankylosing spondylitis associated unusual genotypes haplotypes constructed cases rheumatoid arthritis controls using family data haplotypes generated five common single nucleotide polymorphisms snps haplotype frequencies compared using fishers exact test haplotypes international genetics consortium study also studied family study identified four common haplotypes cases controls apart two rare previously haplotypes examples unusual haplotype combination previously reported others cases expected bearing haplotypes increased family study control due particularly increase haplotype control trend replicated data two bearing haplotypes controls controls association therefore predominantly attributable common haplotypes haplotype combinations
marker assisted selection mas important modern breeding technique found effect markers quantitative trait loci inconsistent leading cases mas failure raising effectiveness model organism drosophila employed study whether effective marker found applied mas crossed stock carrying marker recessive mutation allele yellow gene chromosome three carrying corresponding wild type markers design found marker significant association low body weight association consistent across different backgrounds marker effects female male approximately sigma phenotypic standard deviation sigma respectively next fragment via marker wild stock background generations marker assisted constructed stock body weight decreased female male respectively compared wild stock indicated single low body weight tightly linked marker shortened fragment less deeper using marker white marker fragment also resulted similar decrease body weight induced indicating low body weight located within less interval molecular characteristics marker pcr amplification southern blotting revealed yellow gene deficient stock leading probably influencing developmental process results confirmed existence effective markers applicable mas breeding schemes potential application breeding new
surveillance plays crucial role day day life typical surveillance system continuously monitors vicinity stores surveillance data locally end lots memory energy moreover surveillance records security threat surveillance system damaged paper new design surveillance using smartphone along passive infrared sensor microcontroller unit proposed sensor attached smartphone detect motion video captured motion detected short message services alert sent user straight away overcome memory restrictions smartphone ensure safe storage surveillance records cloud link sent user proposed intelligent surveillance system offers cost effective storage effective energy efficient solution uses computation communication capabilities smartphone storage capabilities cloud
meeting report highlights key trends emerged conference entitled post transcriptional gene regulation plants held july satellite meeting annual meeting american society plant texas molecular biology rna emerging integral part framework plants responses environmental challenges drought heat hypoxia nutrient deprivation light pathogens moreover conference illustrated multitude customized related technologies applied often combination describe dissect complexities gene expression post transcriptional level
rapid urbanization dramatically changes local environment hybrid classification method designed applied multi temporal landsat images ancillary data obtain land cover change datasets support vector machine svm classifier used classify multi temporal landsat enhanced thematic plus images collected pixel level images also segmented mean shift method surface refined based combination segmented objects svm classification results changed areas determined comparing thematic images via weighted multivariate alteration detection transformation method images changed areas input svm classifier land cover maps produced combining unchanged area new classes changed areas land cover change continuously accelerated since remarkably land decreased surface area significantly increased
objectivesto investigate effect serotonergic pathways lower urinary tract sprague dawley rats used following intraperitoneal administration vehicle one serotonin inhibitors bladder normal spinal cord injury sci rats consciousness fos stained using immunohistochemistry spinal cord spinal areas associated sci rats positive fibers observed spinal cord many positive fibers normal rats total number fos positive cells significantly increased sci rats compared normal rats normal sci indicated interruption modulation enhances transmission regarding effect administration number fos positive cells significantly decreased region spinal cord normal rats reduction observed sci rats result demonstrated administration attenuates transmission indicating work mediators endogenous analgesic mechanisms pain pathways projections serotonergic pathways lower lumbar spinal cord modulate transmission administration attenuates transmission result enhancement modulating serotonergic pathways
paper addresses day ahead network constrained thermal unit commitment problem uncertainty problem electrical network considered power flow model phase angles represented directly model associated flow limit constraints dynamically introduced iterative process uncertainty regards stochastic demand supplied thermal plants possibly due configuration high wind penetration two main contributions presented first new compact mixed integer formulation unit commitment constraints minimum times defining multi node constraints comprise integer variables related nodes given sub trees original scenario tree second application local strategy instead standard branch cut algorithm solve problem computational experiments carried ieee system assuming severe constraints transmission lines capacities two scenarios trees hour period
highly transcriptional metabolic reprogramming activation drastically transforms main functions physiology human macrophages across polarization spectrum lipids example modify protein function acting remotely signaling molecules also locally altering physical properties cellular membranes changes play key roles functions highly plastic immune cells due involvement inflammation immune responses wound healing processes report analysis major membrane lipids distinct phenotypes resting classically activated alternatively activated human monocyte derived macrophages different donors samples subjected supercritical fluid chromatography ion mobility mass spectrometry analysis allowed based lipid class facilitating profiling fatty acid composition different levels acid mobilization fatty acid changes observed different lipid classes distinct polarization phenotypes suggesting activation highly specific enzymatic processes biosynthesis lipid signaling molecules cell membrane remodeling production appeared specific marker polarization alterations global composition lipid layer membranes cell provide potential methodology definition determination cellular tissue activation states elsevier inc rights reserved
accurate simulation fuel properties influence performance internal combustion engines complex subject combines many physical chemical concepts combustion phenomena chemical kinetics fluid dynamics turbulence thermodynamics order circumvent complexity concepts many simulations packages engine performance usually consider standard surrogate fuels enough new fuel developments cases study aims evaluate influence different formulations gasoline behavior flexible fuel engine relating physicochemical properties fuels performance efficiency gaseous emissions based experimental dataset generated using different radial basis functions techniques order accurately predict torque fuel consumption specific fuel consumption global efficiency emission twelve blends iso ethanol different engine speeds load conditions leave one cross validation procedure applied automatically select best case able estimate experimental results five fuels within confidence intervals prediction lower elsevier ltd rights reserved
last years wide variety automatic network layout algorithms developed fast heuristic techniques suitable networks hundreds thousands nodes others multi stage frameworks higher quality layout smaller networks however despite decades research currently algorithm produces layout comparable quality human give new human centred methodology automatic network layout algorithm design intended overcome deficiency user studies first used identify aesthetic criteria algorithms encode algorithm developed informed criteria finally follow study evaluates algorithm output used new methodology develop automatic orthogonal network layout method achieves better user study layout best available orthogonal layout algorithm produces layouts comparable quality produced hand
mechanisms resistance bacterial pathogen explored population greater selected fold increased resistance bacterium bacillus compared non selected line defense strategies resistant susceptible insect lines compared uncover mechanisms underpinning resistance possible cost survival strategies uninfected state resistant insects exhibited enhanced basal expression genes related regeneration toxin activity addition insects also exhibited elevated activity genes linked inflammation stress management immune defense fat body following oral infection expression genes elevated fat body lines greater extent resistant line susceptible line gene expression analysis reveals pattern resistance mechanisms targeted sites damaged insect placing greater emphasis tissue repair revealed elevated expression genes fat body epithelium unlike susceptible insects infection significantly reduced diversity richness abundance gut microbiota resistant insects observations suggest resistant line intact antimicrobial factors gut lumen mitigate activity also affects viability gut bacteria remarkably resistant line employs multifactorial adaptations resistance without detected negative trade since insects exhibited higher
use language signal flow graph representation digital filter structures solve three purely mathematical problems including fast inversion certain polynomial matrices deriving analogue rules polynomial evaluation basis computation classes matrices algebraic possible using elementary operations specifically flow reversal signal flow graphs provides unified derivation reveals connections systems theory etc elsevier inc rights reserved
paper reports findings exploratory qualitative study using implementation communities practice learning meaning identity university press communities practice social learning systems organization theory communities practice develop accounting community practice students eight accounting courses participated narratives surveys used data practice develop critical real world professional accounting competencies linking three structural foundations accountability joint enterprise mutual engagement shared repertoire resources competencies promoted core competency framework entry accounting profession retrieved http core competency framework entry accounting profession retrieved http international federation ifac international education standard professional skills retrieved ifac meeting future expectations professional competence consultation future strategies priorities retrieved added value professionals england london author professional bodies include problem solving leadership project management interaction strategy effective maintaining dynamic learning environments increasing students awareness trust open communication creative thinking meaning knowledge owned focus class shifts students study adds limited empirical research forms learning accounting
background sacral nerve stimulation surgical treatment fecal urinary incontinence consists stimulating electrode one sacral holes addition benefit treatment incontinence recent studies showed effective treatment irritable bowel syndrome bladder pain syndrome aim study evaluate effect visceral cross organ sensitization rat model methods model obtained acetic acid bladder rats minutes minutes start experiments visceral sensitivity assessed monitoring change mean arterial pressure response graded colorectal series mechanisms underlying effect rats administered either opioid receptor antagonist nitric oxide synthesis antagonist name neuronal activation dorsal sacral spinal cord measured counting fos immunoreactive cells response colorectal key results acetic acid increased mean arterial pressure variation response colorectal compared saline group reduced variation arterial pressure colorectal induced rise fos immunoreactive cells dorsal spinal cord effect reduced conclusions inferences reduces visceral cross organ sensitization model
muscle injuries lower limb common among professional football players classification made according severity diagnosed radiological assessment grade minor strain minor injury grade partial rupture moderate injury grade iii complete rupture severe injury localized analysis khz made phase sensitive analyzer used assess damage integrity muscle structures fluid accumulation injury injuries diagnosed magnetic resonance imaging mri aim study identify pattern change variables indicators fluid resistance cell structure integrity phase angle according severity mri defined injury difference compared non injured contralateral muscle also measured injury respectively grade grade grade iii showing greater significant decrease greatest relative changes grade iii injuries however decreases indicate fluid distribution proportional severity injury disruption muscle structure demonstrated localized determination increased severity muscle injury significant changes injury decrease indicates pattern disrupted soft tissue structure proportional severity injury
extracted plants genus possesses various pharmacological effects including anti inflammatory activity purpose present study evaluate protective effects underlying mechanisms induced asthma mice fifty mice randomly assigned five experimental groups control group model group dexamethasone group groups number cells production interleukin beta tumor necrosis factor alpha bronchoalveolar lavage fluid measured addition pulmonary histopathology airway resistance raw cells frequency gamma expression evaluated study demonstrated effectively decreased count inflammatory cytokines production addition treatment significantly inhibited raw percentage gamma expression induced animals compared model group histological studies also demonstrated significantly suppressed induced lung tissue compared model group findings supported prevent allergic asthma mouse model
many resource allocation problems formulated constrained maximization utility function network utility maximization applies optimization techniques achieve decomposition dual method several important problems example joint source rate control routing scheduling design optimized using framework work introduce important network security concept trust formulation integrate nodes trust values optimization framework trust values based interaction history network entities community based monitoring objective avoid routing packets though paths large percentage malicious nodes also add end end delay constraints traffic flows delay constraints introduced capture imposed quality service qos requirements traffic flow
evaluate efficacy severe frequent recurrent anterior patients hla positive ankylosing spondylitis study eyes hla positive patients resistant anterior received subcutaneous per month due frequent analyzed retrospectively october assessment criteria activity number recurrence visual systemic corticosteroid drug requirement maintenance remission twelve patients eyes hla positive ankylosing spondylitis anterior treated month remission observed eyes hypertension developed one subject second dose therefore treatment stopped subject excluded study median follow time months interquartile range reaction seen except patient stopped treatment topical systemic steroid necessity needed except two cases oral systemic maintenance visual significantly increased new effective choice maintaining remission prevention severe resistant anterior patients hla positive ankylosing spondylitis
linux operating system los sophisticated man made system one ubiquitous operating systems however little research structure functionality evolution los prospective networks paper investigate evolution los network major releases los ranging versions modeled directed networks functions denoted nodes function calls denoted edges found size los network grows almost linearly clustering coefficient degree distributions almost degree follows exponential distribution degree degree follow power law distributions explore functionality evolution los network observed evolution functional modules shown sequence seven events changes including continuing growth contraction birth splitting death merging events means statistical analysis events top largest components arch drivers net shown continuing growth contraction events events work better understanding describing dynamics los evolution elsevier rights reserved
background invasive disease incidence increased starting caused sequence type clone region particularly affected rate per person years immunization campaign launched using component protein based vaccine aimed evaluate impact campaign years initiation methods immunization registry data invasive disease cases public health authorities confirmed culture polymerase chain reaction july december analyzed including multivariate poisson regression model incidence rates results end campaign targeted residents months years age following initiation campaign case occurred among whereas cases reported among adult residents third case child stayed region week prior disease onset incidence decreased regions years sporadic cases continued occur multivariate analysis showed significant effect campaign region relative risk conclusions results suggest high level protection provided following mass vaccination regional level along safety data supports current recommendations use controlling outbreaks caused clones covered vaccine
parasite causes degenerative neurological disease due host range expansion emerging threat requires close monitoring protein kinases implicated myriad critical functions host cell invasion cell cycle progression host immune response used various bioinformatics methods define phylogenetic relatedness identified putative clustering within various eukaryotic kinase groups although containing universally conserved group devoid moreover contains six conserved group several atypical kinases including identified notably devoid virulence associated alpha kinases two three enzymes high sequence similarities experimental studies putative identified study required validate functional roles understand involvement mechanisms regulate various cellular processes host parasite interactions given survival current study offers platform future development novel therapeutics instance via application inhibitors block parasite invasion development host
mapping relational data linked data essential prerequisite evolving world wide web web data propose methodology evaluate quality mappings set objective metrics methodology whose key principles approved survey among experts applied evaluate automatically manually performed mappings regardless representation main contributions paper assessing quality requirements mappings relational databases proposing methods measuring given mapping meets requirements usage individual metrics illustrative examples real life application additionally provide guidelines improve given mapping regard specific metrics
people commonly question whether highly psychopathic offenders little scientific research addressed question despite key developments last years two relevant areas reliable measurement psychopathy effective treatments reducing criminal antisocial behavior offenders one obstacle progress confusion defining psychopathy necessary preliminary step advancing intervention principal issues review past recent research psychopathy treatment newer designed studies suggest grounds psychopathy although psychopathy characteristics along indices criminal risk signal challenges conceived programs higher risk offenders reduce highly psychopathic offenders appear reducing dynamic risk factors clear indications yet whether pcl psychopathic offenders differ high risk offenders ability respond treatments questions whether psychopathy responds treatment forms treatment take yet addressed conclude suggesting advances come use divergent measures psychopathy particular dynamic measures psychopathy traits allow document whether change occurring elsevier ltd rights reserved
present study aimed verify body weight influence self perception terms body image mood states dissatisfaction physical appearance risk eating disorders particular evaluated differences women normal weight overweight obese delicate phase verify different emotional structures linked bmi thirty two women normal weight overweight obese belonging department obstetrics university hospital individually interviewed body test eating disorder inventory profile mood states used evaluation findings showed bmi significantly correlated mood states body perception furthermore significant differences emerged eating attitudes behaviours specific aspects related weight gain body shape perception symptoms classically associated risk developing eating disorder
purpose review social media great impact aspects life throughout world utilization social media occupational lung disease however much limited article summarizes recent literature concerning social media occupational lung disease identifies areas additional use recent findings social media used six relevant areas information dissemination peer peer communication survey research data collection participatory research data acquisition assessing public concerns knowledge generation clear advantages information dissemination experts workers peer peer basis although variable credibility accuracy concerns persist research social media used acquiring data purposes efficiently collecting information specifically research benefits efficiency large data sources concerns inadequate specification recruitment strategies limited control data quality summary potential benefits using social media lung health workplace interactions much greater limited current utilization
innovative highly efficient random vibration series algorithms pseudo excitation method effective applications bridge dynamics presented transforms stationary random vibration equations simple harmonic vibration equations transforms non stationary random vibration equations ordinary equations motion structures subjected deterministic time history loading therefore solution processes considerably simplified also computational effort greatly reduced numerical results remain highly accurate method now widely used chinese engineering community adopted recommended chinese official guidelines seismic design highway bridges also described detail vibration shock crc press bridge engineering crc press means flutter based analysis successfully performed main span bridge second longest suspension bridge world located known region islands east china sea addition also become widely used research design tool vehicle engineering china including vehicle bridge dynamic interaction problems finite element model power spectral analysis high speed train degrees freedom presented along brief introduction presentation also show number practical engineering examples successfully used related research design
photovoltaic arrays means convert solar power electricity significant way generate renewable clean energy efficient photovoltaic generate constantly maximum possible power different environmental conditions finding maximum generated power known issue industry using methods classic control theory good results however solutions case specific resulting increased set effort work proposes universal control method based reinforcement learning method tracks maximum power point photovoltaic source without prior knowledge markov decision process model maximum power point tracking photovoltaic process defined algorithm proposed evaluated number photovoltaic sources proposed control method advantage applicable different sources minimum set time evaluate control method performance number simulations run different environmental operating conditions comparison conventional method observe performed results show quick response close optimal behavior without requiring prior knowledge elsevier ltd rights reserved
nuclear energy considered important part long term energy mixture china accompanying development nuclear power program extensive research development activities initiated nuclear thermal hydraulics recognized key subject development nuclear technology target nuclear thermal hydraulics remove heat safely fuel thermal hydraulics activities china cover three main areas namely reactor core thermal hydraulics safety related thermal hydraulics fundamental thermal hydraulics paper gives brief summary ongoing activities three areas focus selected topics mixing heat transfer distribution fuel assemblies two phase distribution external reactor vessel cooling conditions heat transfer supercritical fluids state art ongoing works challenging aspects presented discussed
flow viscous fluid induces shear forces provide benefit clinical practice example guide implant insertion produce static pressure partition wall research studying effects viscous fluid provides data better understanding fluid mechanics however perfusion viscous fluid damage work studied physiological anatomical effects viscous fluid rate min artificial sodium four different concentrations different concentrations applied either sequentially individually different perfusion fluid entered round window basal order entire space compound action potentials cap measured perfusion perfusion increasing concentrations order increasing viscosity cap thresholds generally increased threshold elevation perfusion small almost zero borderline case higher concentrations significantly elevated cap thresholds histology showed intact membrane thus cap threshold elevation likely due broken likely caused shear stress produced flow viscous fluid results analysis indicate sustain without significant cap threshold shift shear stress beside finding perfusion cases temporary cap threshold shift observed perhaps due presence clearance viscous fluid within temporary position shift organ perfusion short latency positive peak appeared cap waveform due change traveling wave pattern distortion elsevier rights reserved
roughly past ten years working creating using virtual remote laboratories science engineering education providing number software tools facilitate creation virtual laboratories simulations used promote active role students studying certain phenomena remote laboratories add extra value using real hardware typically distant location shows students additional issues appear using real equipment pedagogical benefits particularly effective laboratories designed used using interactive engagement approach work received collaboration many people interested improving education particular physics control engineering taught features software platforms required create virtual remote laboratories review lessons learned past ten years successful outcomes apply lessons prepare integration computers tablets mobile devices platform independent cloud based computing laboratories ifac international federation automatic control hosting elsevier ltd rights reserved
letter presents image processing technique based theory hilbert transform determine coastal marine radar image sequences use hilbert transform enables difficulties complications inhomogeneous image analysis avoided addition number steps complex computations avoided using numerical algorithm hilbert transform hilbert transform suitable signals first applied image procedure decompose irregular wave patterns different single wave period images analysis simulated wave field radar image sequences demonstrated high correlation estimated depths reference depths causes errors estimations also discussed
effects essential oil oil oils antioxidant characteristics investigated assays cellular activities content mouse melanoma cells performed expression related proteins determined western blotting possible signaling pathways involved essential oil mediated also investigated using specific protein kinase inhibitors results revealed flower essential oil effectively suppresses intracellular activity decreases amount mouse melanoma cells essential oil also exhibits antioxidant properties effectively decreases intracellular reactive oxygen species ros levels volatile chemical composition essential oil analyzed gas chromatography mass spectrometry chemical constituents essential oil followed hydrocarbons hydrocarbons results indicated flower essential oil inhibits antioxidant properties regulating mitogen activated protein kinases mapk protein kinase signaling pathways present study indicates essential oil potential developed skin care product
little known mental health female sex workers women living hiv aids republic hiv prevention testing treatment project estimates prevalence depression identifies key contributing factors outcome female sex workers women living hiv aids comparison group participants female sex workers women living hiv aids comparison group hiv negative women sex workers republic participants completed questionnaires assessing demographic characteristics depression female sex workers women living hiv aids completed additional questionnaires hiv sex work related internalized stigma depression prevalent among female sex workers women living hiv aids comparison group adjusted logistic regressions showed internalized stigma associated depression female sex workers women living hiv aids permanent income associated outcome female sex workers comparison group
paper optimized power saving algorithm using joint power peak signal noise ratio characteristics among multiple frames proposed existing state art methods optimal decision point made consideration current frame target frame set frames therefore power performance proposed work show better power performance achieved assigning different target frame different frames proposed algorithm decisions points associated frames made ratio point evaluated put algorithm design optimization problem formulated solution search procedure proposed compared state art methods proposed work performs better aspects power power proposed work methods better every tested video power high average power low average
purpose purpose study compare cutaneous surface parameters non skin psoriatic patients corresponding areas control subjects methods sixty six psoriatic patients grade severity without arthritis without therapy systemic biologic drugs healthy controls enrolled observational case control study exclusion criteria current past psoriasis dermatitis psoriasis treatment immune suppressive agents ultraviolet last months topical treatment last weeks evaluated non skin region psoriatic plaque neighboring areas controls areas considered results values significantly lower psoriatic plaques controls showed significantly higher values non skin plaques psoriatic patients corresponding areas controls significantly lower areas psoriasis differences found patients treated biologics without arthritis conclusion evaluating surface skin parameters psoriasis useful better understand mechanism suggest new therapeutic approaches
paper investigates class linear multi agent network systems nodes coupled dynamic edges sense edge dynamic system attached outputs edge dynamic systems form external inputs node dynamic systems termed neighboring inputs representing coupling actions nodes outputs node dynamic systems inputs edge dynamic systems several cooperative output regulation problems posed including output synchronization output cooperation master output cooperation output cooperation specified making neighboring input weighted sum edge outputs track predefined trajectory cooperation node outputs distributed cooperative output regulation controllers depending local states neighboring inputs presented designed combining feedback theories internal model principle simulation example cooperative current control electrical network illustrates potential applications analytical results crown copyright published elsevier ltd rights reserved
background last fifteen years possibility delivering programs internet based platforms explored studies evaluating programs shown good acceptable retention rates context developed smartphone application simple collecting information mood symptoms offering personalized messages main aims study evaluate feasibility acceptability satisfaction smartphone application methods study conducted march august participation study proposed consecutive sample adult patients attending outpatient mental health clinic sociodemographic data clinical functional assessments alongside smartphone ownership uses collected baseline months follow item likert scale satisfaction questionnaire also employed results participants initially enrolled study remained actively using application months whole sample interacted application mean days days completed daily tests participants agreed experience using application satisfactory limitations diversity smartphones operating systems led moderate although representative sample number additionally subjective data reporting narrow time frame use stability patients affected results conclusions results confirm particular intervention feasible represent satisfactory acceptable instrument self management bipolar disorder add usual treatment future clinical trials still probe efficacy elsevier rights reserved
paper examines political activity united states support minority egypt analysing strategy reveals years focused united states international bodies order raise international awareness minority status using strategy framed struggle rights manner unity narrative strategic choices paper shows understanding limitations strategy alongside change structure opportunities egypt led change pattern activity alongside international involvement developed additional strategies including strengthening influence even direct action vis vis authorities paper pattern action represent minorities attention structure opportunities variety relationships effect ability become significant force shaping life minority
risk analysis security threats computer networks one challenging fields network management security risk analysis usually done security experts although utilize analysis tools need expert still inevitable reduce need security expertise network yet performing security risk management paper proposes models represent experts security information propose class diagram built necessary classes security analysis networks classes building blocks needed estimation probability effects security threats model created represents security information needed analysis analyze network needed objects provided classes objects form security model network threats risks specified objects network security model information needed information usually available documents network via automated show applicability proposed model test network result security model network contains security threats also risks obtained
tryptophan precursor serotonin one investigated amino acids supplementation increase levels brain reason numerous studies investigated whether administration positively influence social behavior relies serotonergic function review available studies clarify circumstances supplementation modulate social behavior supplementation seems improve control social behavior patients individuals suffering disorders behaviors associated dysfunctions serotonergic functioning contrast healthy humans supplementation seems promote social behavior although research needed understand relations individual differences functioning social interactions context conclude promising tool modulating social behavior elsevier ltd rights reserved
advanced medical devices exploit advantages embedded software whose development subject compliance stringent requirements standardization certification regimes due critical nature systems paper presents initial results lessons learned ongoing project focusing development formal model subsystem software controlled safety critical active medical device responsible renal replacement therapy use formal approaches development highly recommended standards regulations motivates recent advancement state art related methods tools including event applied paper expected presented model development approach specification high confidence medical system contribute still sparse experience base available disposal scientific practitioner community formal methods software engineering
birds migrate long distances either reach breeding areas spend winter benign places migration frequently stop rest fuel date know little regarding decide ready continue physiological signals birds brain fuel sufficient migration network hormones regulates food intake body mass vertebrates including recently discovered peptide hormone show reflects body condition influences migratory behavior wild birds measured levels wild captured site manipulated blood concentrations test effects food intake migratory found concentrations larger fat scores higher birds without fat stores injections decreased food intake increased migratory results represent experimental evidence appetite regulating hormones control migratory behavior study migration physiology provides missing link ecologically dependent factors condition timing migration addition offers insights regulation hormonal system controlling food intake energy stores vertebrates whose disruption causes eating disorders obesity
work presents method pipeline defects using small number radiographs taken different angles around pipe method relies knowledge setup geometry use multiple images require calibration objects included setup aimed use situations access difficult pipeline given set radiographs background method used extract defects images using ray tracing algorithm knowledge experimental setup range possible locations defect space calculated constraints applied potential defect shapes positions refine defect range method tested simulated experimental flat hole defects simulated corrosion patch defects lateral axial sizes ranging thickness results demonstrate good consistent ability calculate lateral axial defect dimensions within true size defect thickness calculations difficult errors significant cases defect thickness calculated within actual value often closer errors thickness due meaning calculation used place maximum limit potential defect size rather actual estimate thickness still useful example deciding whether defect requires investigation
background syndrome neurodevelopmental disorder caused mostly disruptions gene null mice show imbalances neuronal excitability synaptic communications several previous studies indicate synaptic gaba receptors gaba alleviate like symptoms mice addition synaptic gaba group gaba found outside synaptic capability produce sustained inhibition potential therapeutic targets control neuronal excitability methods wild type null mice randomly divided four groups receiving gaba agonist vehicle control respectively low dose administered neonatal mice lactation like symptoms including lifespan breathing motor function social behaviors studied mice became mature changes neuronal excitability biosynthesis enzyme expression studied electrophysiology molecular biology results evident adverse side effects early life exposure extended lifespan alleviated breathing abnormalities enhanced motor function improved social behaviors null mice beneficial effects associated stabilization locus neuronal excitability improvement biosynthesis enzyme expression conclusions treatment early lives therapeutic approach like symptoms null mice perhaps people
fuzzy current regulation permanent magnet synchronous generator designed implemented paper system configuration dynamic model first introduced design fuzzy current regulation demonstrated moreover stability analysis proposed drive system accomplished control algorithms realized microcontroller performance proposed current regulation verified experimental results
background aims immature platelet fraction ipf represents younger larger sized circulating platelets potential marker platelet reactivity major cardiovascular events aimed assess relationship ipf levels prevalence extent coronary artery disease cad patients undergoing coronary angiography methods cohort consecutive patients undergoing coronary angiography single centre included significant cad defined least vessel stenosis severe cad defined left main three vessel disease ipf levels measured admission routine blood cells count results included patients divided according values ipf ipf levels directly related active smoke non acute coronary syndrome indication angiography higher levels uric acid respectively lower platelet count features significantly differ according values ipf lower degree flow patients higher percentage platelets higher rate lesions involving ipf levels affect prevalence cad adjusted severe left main three vessel cad adjusted conclusions present study shows among patients undergoing coronary angiography immature platelet fraction ipf associated prevalence extent coronary artery disease therefore overlooked marker coronary atherosclerosis elsevier rights reserved
efficiency analysis different configurations electric propulsion systems presented paper particularly three different permanent magnet synchronous machines considered electric motor characterized different speed operating ranges constant power speed regions addition four transmission systems arc introduced briefly described single gear multi gear continuously variable magnetic gear transmission among suitable one chosen accordance inherent features subsequently four designed based specific vehicle traction power requirements proposed configurations tested three driving cycles order assess efficiency different driving conditions
analog signal processing applications settling performance employed operational amplifiers usually great matter low voltage environment modern technologies transistors allowed stacked three stage amplifiers gaining interest unfortunately design optimization three stage based settling time still suffer lack comprehensive analysis settling behavior closed form relations settling time error parameters paper thorough analysis settling response three stage nested compensated including linear non linear sections presented analysis leads design methodology determines circuit requirements desired settling time error based settling time allows optimizations power consumption area copyright john wiley sons ltd
first approved antidepressant mediates activity pathway rather system meta analysis aims summarize date report efficacy major depressive disorder published results pubmed cinahl cochrane library embase psycinfo databases searched randomized double blind trials comparing placebo antidepressant major depressive disorder change severity depression result intervention main outcome measure data necessary compute standardized mean difference outcome additional sample parameters likely influence main outcome extracted selected studies summary effect sizes various groups subgroups computed control placebo antidepressants arms nine trials involving severe cases depression either placebo antidepressants superior placebo small margin superiority dose antidepressants even smaller although evidence superiority placebo selected antidepressants whether magnitude effect size clinically significant sample characteristics relevant general patient population major depressive disorder
much media violence research occurred principally united states based fundamental error correlation variables consumption media violence acted aggression inferred many researchers causal relationship article suggests scholars infer correlation miss important point propose rescue deeply corpus applying statistical principles account theoretical methodological much media violence literature probabilistic calculations article suggests rather argue causal hypothesis productive conceptual methodological confusion study area product dissolution causal argument putative causal relationship consumption media violence social aggression
paper show apply bases compute inverse matrix multivariate rational functions entries coefficients rational functions depend parameters give sufficient conditions inverse properly addition extend method weighted present empirical analysis shows good timing performance method elsevier inc rights reserved
comprehensive analysis framework study green building incremental cost given paper perspective whole life cycle discuss concept characteristics incremental cost providing overall process whole stage full range recognition quantitative based overall analysis factors build framework cost whole life cycle provide important theoretical practical significance study development green building
psychosocial function adherence antiretroviral regimen key factors human immunodeficiency virus hiv disease management trait deficit ability identify describe feelings emotions bodily structural equation model used test whether high levels indirectly relate greater non behavior hiv disease severity via psychosocial dysfunction blood draws hiv viral load lymphocyte along psychosocial surveys collected hiv positive adults aged years structural model supports significant paths non active patient involvement psychological distress lower social support psychological distress non active involvement non behavior non adherence greater hiv disease severity second model confirmed effect greater patient path social support non active patient involvement altogether indirectly linked hiv disease management association poor psychosocial function however greater patient negative impact relationship quality healthcare providers members ones social support network
paper presents fine grain parallel version kernel procedure using open multi processing api set points taken input initially sorted along space filling curve two points close insertion order also close sorted set points divided subsets equal size version kernel points time barriers provide required synchronization needed multiple insertion order avoid data simple approach exhibits two standard problems parallel computing load imbalance parallel two issues addressed using two level version kernel tests show billion generated core machine intel ghz memory less minutes wall clock time speedup compared single implementation published elsevier ltd
structure telomeres four species evaluated southern blotting fluorescent situ hybridization revealing chromosomal end consists repeat presence coding gene verified successively genome revealing shares sequence identity ranging vertebrate possesses two main domains involved activity interestingly expression verified different somatic tissues suggesting activity restricted human cells study telomeres strain variable chromosome number showed initiate novo synthesis telomere sequences internal resulting stabilization chromosomal fragments
children autism spectrum disorder asd experience internalizing externalizing problems higher rates typically developing children social impairment present study compared impairment scores social responsiveness scale edition scores children years male asd either without heightened levels anxiety adhd symptoms per parent report children heightened anxiety problems showed higher scores four subscales social cognition social communication social motivation restricted interests repetitive behavior children heightened adhd traits showed higher scores two subscales social communication social awareness findings suggest similarities differences social deficits asd anxiety adhd symptoms
background influenza infection result severe disease debilitating complications young children highest rate influenza various factors influencing influenza susceptibility severity objectives study aimed determine disease burden assess risk factors severe influenza south australian children years age methods influenza admissions tertiary paediatric hospital south australia identified data laboratory confirmed influenza cases collected including infecting influenza strain infections pre existing medical comorbidities potential risk factors predictors high level care assessed using logistic regression results total children laboratory confirmed influenza admissions occurred children without underlying medical risk factors eighteen children required high level care underlying medical risk factors deaths reported majority children influenza infections identified children influenza associated requirement higher care history food allergies iron deficiency conclusions influenza severe illness even children without underlying medical conditions identification influenza strain history food allergies iron deficiency predictors severity cases warrants investigation important implications preventative strategies reduce burden childhood influenza
electrical instrumentation control systems built copper mine found possess significant errors hindered asset owners ability undertake effective efficient operations maintenance systems information model used retrospectively create connected system ensure physical equipment associated connections constructed modelled object database creating existing errors built documentation quantified cost savings achieved future planned copper mine similar design identified limitations using conventional computer aided design cad design document discussed recommended retrospectively creating provide owners operators significant productivity benefits ensure assets integrity case study presented provides asset owners operators empirical evidence challenge conventional thinking surrounding design engineering documentation using cad alternatively consider use elsevier ltd rights reserved
background considered fundamental drugs treatment broad range cancers several side effects limit usage drug induced nail reported one striking dermatological side effect study aimed evaluate compare side effects doxorubicin help forty one consecutive patients women men diagnosis cancer gastric cancer breast cancer prospectively enrolled period six months patients categorized according chemotherapy regimens administered received group day day days every weeks received group every days without acid doxorubicin received group doxorubicin every days patients asked whether diabetes mellitus peripheral neuropathy weeks chemotherapy patient evaluated clinical examinations nail examination performed using descriptive statistics computed means standard deviations frequencies chi square test fishers exact tests used statistical analysis significance threshold patients demonstrated clinical signs nail nail observed patients received doxorubicin patients received statistically significant relationship nail type regimen administered fishers exact test addition statistically significant results observed nail fishers exact test nail peripheral neuropathy fishers exact test conclusions cause considerable distress patients noninvasive imaging method increases diagnostic accuracy lesions typical features consist homogeneous gray background thin longitudinal gray lines allow clearly make correct diagnosis studies needed assess clinical findings
purpose aim prospective study compare non asian subjects pharmacokinetics safety tolerability two short acting beta adrenergic antagonists administration three different dosages materials methods conducted single center prospective double blinded randomized study three cross periods healthy subjects women men mean age years receiving three doses either newly developed concentrate formulation concentrate formulation three doses formulation parameters safety tolerability assessed findings results two formulations reported previously similar concentrate formulation maximum blood concentrations rapidly reached mean max ranged min min parent drugs disappeared fast blood stream minutes minutes low doses respectively despite comparable injection rates respectively onset significant heart rate reduction occurred earlier response min response min addition significantly lower heart rate values obtained every dose level comparison compounds reduced systolic blood pressure comparable degree especially highest dose duration blood pressure reduction longer compared seven mild moderate adverse events occurred administration five occurred administration serious adverse events reported study
objective early victimization childrens risk developing psychopathology recent findings suggest disruptions developmental processes related symptoms posttraumatic stress partially account association early victimization subsequent psychopathology present study prospectively tested temporal sequencing associations using measurements large diverse sample children high risk victimization method study measured victimization direct indirect familial violence externalizing internalizing problems among children girls boys participated longitudinal studies child abuse neglect results structural equation modeling revealed addition directly impacting psychopathology childhood victimization contributed internalizing externalizing problems children middle late childhood indirectly role largely similar girls boys investigated early reports maltreatment identified early risk victimization conclusions study delineated role development psychopathology following early victimization findings highlight importance carefully assessing underlying trauma symptoms considering diverse presentations psychopathology among youth
quite important mathematical tools since many systems mathematically modelled ultimately take equations rather easy algebraic fit computer programming needs quite many circumstances produce solutions however generally desired find asymptotic behaviour general term relevant sequence convergence therefore practicality issues one general tendencies find general term asymptotic behaviour ordering number grows integral representation generating function depend individual sequence elements tried done almost types even though linear cases gain importance others effectively investigated using many linear algebraic tools despite seem rather trivial lot theoretical fine tuning issues construction true integral representations true intervals real axis paths complex domains work devoted focus issue starting scratch better understanding matter example cases chosen best illuminate situations get information future generalization even though work considered introductory level
important applications platinum alloys related platinum group metals phases complete phase diagrams systems important materials engineering currently accepted phase diagram system earlier experiments claim ordered structure characterized computational predictions analogy system complete examination system computational experimental means suggests phase diagram similar system unknown compound claimed found structure inc published elsevier ltd rights reserved
due increase number internet users electronic commerce grown significantly last decade electronic one famous commerce applications even security robustness schemes still remain challenge requirements like privacy bid value threat attackers protocol leak privacy bid value keeping requirements mind firstly proposed controlled blind signature scheme schemes able trace using blind bid electronic scheme proposed incorporated notion blind signature schemes moreover schemes based upon elliptic curve cryptography ecc provides similar level security comparatively smaller key size discrete problem based protocols analysis shows requirements protocol total computation overhead lower existing schemes
prior studies identified key factors influence recycling intention however studies rarely pay attention interaction attitude subjective norm influences recycling intention study applied conceptual model extending theory planned behavior addressing gap study collected responses street survey hong kong findings revealed two interaction terms experiential attitude subjective norm instrumental attitude subjective norm influenced recycling intention implies subjective norm plays crucial role motivating recycling behaviors moreover subjective norm increase likelihood recycling people exhibiting positive experiential attitude motivate people possess limited knowledge recycling benefits practicing recycling behaviors policy implications drawn findings limitations study future research direction also discussed elsevier ltd rights reserved
study uses investigate effects suggestion social influence belief upon accuracy event participants watched video seemingly bending metal key power half participants heard suggest key continued put table half additionally participants exposed either negative social influence reporting key continue social influence positive social influence reporting key continue participants exposed verbal suggestion significantly likely report key continued additionally participants reported key continued positive social influence condition compared two social influence conditions finally likely report key continued non
central behavior cognition way sensory stimuli represented neural systems distributions stimuli rich structure however brain captures exploits unclear consider different sources perhaps prevalent form structure namely hierarchies one prevalent cases namely representation images review experimental approaches across range spanning inference memory recall visual adaptation investigate constrain hierarchical representations also discuss progress building hierarchical models representation images potential clarify structure world reflected biological systems suggest need closer embedding recent advances machine learning computer vision design interpretation experiments notably utilizing understanding structure natural scenes creation structured synthetic stimuli
digital dual mode linear quadratic regulator feedforward optimal controller presented allows voltage control boost converter wide load range condition whether continuous conduction mode discontinuous conduction mode based conventional method proposed controller designed makes following two improvements first order eliminate phase error caused right half phase zero emerged non minimum phase boost converter feedforward controller implemented zero phase error tracking control technique inverse non minimum phase system unstable second since models converter different proposed control strategy allows boost converter autonomously operate controller utilising mode detector proposed mode detector greatly enhances control performance operating modes finally proposed controller implemented voltage control boost converter simulation experimental results show proposed controller offers better performance transient response frequency response conventional controller
objective study explore gender constructed english ethiopia students book grade four order find actions representations employed discourse style respectively case study conducted using three dimensional model critical discourse analysis despite gender sensitive education training policy findings revealed texts book manifestation struggle discourse tries maintain existing social order gender construction one hand attempts change status actions characters promote gender construction activity attribute based representations characters reproduce existing stereotypical gender constructions society fall line perspective gender roles
continuous monitoring chemicals environment important control fate protect human health flora acids detected frequently different environmental compartments last years drawn much attention environmental persistence potential water important source transport present study distributions river water wastewater treatment plant effluent tap water eastern part germany western part kenya investigated eleven acids five acids analyzed using liquid chromatography tandem mass spectrometry sum mean concentrations eight detected drinking tap water dominated acid mean concentrations detected beta white germany respectively annual flux river estimated effluent found contain four times higher levels river water dominated times higher concentration level advocates point source water bodies short chain long chain mean concentrations kenya samples areas respectively indicating population directly affected emissions surface waters discussion includes thorough review comparison recently published literature reporting occurrence aqueous matrices
bio polymerization dna become essential chemical component dna sequencing technology now basic tool molecular biology research method fluorescent dye labeled analogues used dna sequencing detection terminated dna fragment single labeled incorporation dna pcr conditions report describes designed novel amino functionalized analogue polymerase activities dna polymerase gel electrophoretic techniques mass page analyses strongly support incorporation dna oligonucleotide dna polymerase like control substrate resultant dna oligonucleotide functionalized amine group incorporation polymerase hence provide opportunities prepare conjugated dna biomolecules dyes fluorescence molecule without modifying structure elsevier ltd rights reserved
immense work presented paper high frequency sinusoidal oscillator using positive second generation current controlled conveyor minimum passive components implemented using single current feedback operational amplifier single operational trans conductance amplifier ota frequency time period tuned maximum mhz using external bias current performance proposed circuit practically verified using ics ota results topology suitable monolithic fabrication
past decade lean manufacturing manufacturing processes numerous even organizations already conscious quality cost delivery benefited principles foundation lean manufacturing elimination non value added elements waste three important value streams realization product engineering value stream manufacturing value stream information management value stream paper focuses engineering value stream methods lean manufacturing applied waste elimination engineering dissemination lean manufacturing principles engineering significant benefits already derived lean manufacturing part enterprise little attention given systematic method lean engineering aims reducing engineering lead time also identifying measuring eliminating waste engineering processes engineering organizations lack basic methodology waste elimination paper proposes systematic ten step method engineering waste elimination systematic method help engineering organizations systematically identify measure eliminate engineering wastes engineering processes systematic method used demonstrate elimination waste engineering application manufacturing equipment installation manufacturing engineering process todays competitive world ability bring better products market faster become focal point competition use systematic method engineering waste elimination holds significant promise organizations outperform quality cost delivery
objective building recent models anorexia nervosa emphasize importance impaired social cognition development maintenance disorder present study aimed examining whether women difficulties inferring peoples emotional mental states healthy women method social cognition assessed adult women age matched healthy women overcome limitations previous research social cognition processing social information examined complex ecologically valid manner movie assessment social cognition reflects complex real life social interaction allows emotional non emotional mental state inference different types errors results women showed poorer emotional mental state inference whereas non emotional mental state inference largely intact groups differ theory mind complex mental state reasoning performance independent levels eating disorder psychopathology symptoms depression anxiety discussion findings suggest associated specific difficulties emotional mental state inference despite largely intact mental state inference upon replication larger samples findings advocate stronger emphasis socio emotional processing treatment wiley periodicals inc
response infant life threatening child abuse parental childhood abuse history known one robust risk factors offspring addition childhood abuse history adverse childhood exposures need considered due occurrence however studies investigated impact caregivers infant study aims investigate association among caregivers infants japan questionnaire administered caregivers participating four month health september august city japan assess parental death parental mentally parents intimate partner violence physical abuse neglect psychological abuse economic toward infants logistic regression analysis used examine cumulative individual impacts analyses conducted total reported experienced least one ace childhood found ipv significant association infant total number associated either findings suggest response occur regardless population based strategies target caregivers prevent infants needed elsevier ltd rights reserved
caused predominantly candida albicans prevalent infection patients advanced aids defects immunity head neck cancer characteristic feature fungal invasion oral epithelial cells one mechanism albicans oral epithelial cells expressing interact epidermal growth factor receptor egfr epithelial cells stimulate organism however signaling pathways function downstream egfr mediate albicans poorly defined report albicans infection activates hydrocarbon receptor leading activation family kinases turn egfr induce fungus furthermore treatment oral epithelial cells interferon gamma inhibits fungal inducing synthesis cause prolonged activation thereby interfering albicans induced egfr signaling treatment mice inhibitor decreases phosphorylation egfr oral mucosa reduces fungal invasion severity thus data indicate plays central role governing pathogenic interactions albicans oral epithelial cells suggest receptor potential therapeutic target importance caused predominantly fungus albicans oral epithelium several mechanisms one mechanisms induced stimulated fungal bind epithelial cell receptors egfr receptor binding causes rearrangement epithelial cell leading formation fungus pull epithelial cell discovered acts via egfr induce albicans finding small molecule inhibitor mice suggests strategy targeting host cell signaling pathways govern epithelial cell albicans holds promise new approach preventing treating
analysis paired cerebrospinal fluid csf serum samples focusing yield different patterns aid differential diagnosis central nervous system cns disorders rarely single csf restricted igg band included within patterns detected association inflammatory disorders multiple sclerosis however diagnostic meaning abnormality still uncertain main aim multicenter study establish frequency disease associations single csf igg bands differences csf profiles diseases follow patterns also evaluated medical records patients underwent csf analysis included year period retrospectively participating centers used similar techniques one hundred fifty one csf reports showed single csf restricted igg bands patients definite diagnosis cns inflammatory demyelinating diseases frequent tumours inflammatory peripheral nervous system diseases diseases follow patients repeated csf analysis developed band pattern findings indicate single csf igg bands tend associate diseases characterized involvement humoral immune responses strongly support notion abnormality regularly reported thus clinicians possible inflammatory disorders cns
paper devoted study statistical mechanics trapped obtained trapping spherical gravitational wave box consequence discrete spectrum dependent index similar harmonic oscillator one obtained statistical study performed mean sum two discrete distributions different dependent frequencies important application derive entropy formula static black hole requiring black hole internal energy provided rest energy without particular quantum gravity theories seriously suggests interior black hole composed trapped temperature proportional factor similar equal horizon temperature elsevier rights reserved
refers finding given cipher text problem reduces finding correct key set possible keys basically search problem many researchers put lot effort accomplish task efforts used conventional techniques however soft computing techniques like genetic algorithms generally good optimized search though applicability techniques still point work carries extensive literature review techniques finds gaps order put proposed technique perspective work also finds applicability cellular automata new technique proposed verified texts around words text encrypted times using proposed technique work also compared employing genetic algorithm experiments carried prove technique way cellular automata paper also discusses future scope work
first kind pilot scale redox based storage system set operated near realistic conditions inside solar power tower plant storage unit made supports coated redox active material cobalt oxide experimental campaign carried consisting charge discharge cycles heat absorbed released chemical reaction became clearly evident temperature evolution inside reactive material allows store release energy constant temperature crossing respectively reduction oxidation temperature pair storage performance factor defined evaluate experiment approaches ideal behavior complete campaign measurable cycle cycle degradation observed system average capacity close ideal case advantage storage quantified comparing storage capacity storage unit made system offered almost double storage capacity volume case elsevier ltd rights reserved
education type higher education singapore focuses technical industrial oriented education observed recent student significant increase number students rising concern among educators potential differences approach learning differences lead difficulties student engagement academic material design student performance assessment name difference cultural lead difference understanding learning actually differences lead students different strategies behaviours regulate learning example general asian students traditional educational concept emphasis way learning tend contrast strongly acceptance independence thought verbal learning development meaning generally promoted desirable behaviours among european students recent years rapid development information communication technology ict played increasingly important role education adoption technology teaching learning become next step towards enhancing learning experience students introduction technology enhance learning experience leads explosion new ideas creative ways engaging students school information technology teaching community already started introduce online tools material repository dissemination online learning assessments project group collaboration discussion work means students different cultural educational background adopt technology based online learning environment education research therefore aims study interaction international students diverse cultural educational backgrounds solve range problems form computer programming tasks within online learning environment using eye tracking technology preliminary findings led suggest students different educational foundations different countries shown significant differences learning progress performing tasks within online learning environment findings thus help educators promote learning among diverse group students differential learning models
paper shows method developed van generalized calculate resistance two vertices symmetrical whose edges identical resistors method applied number structures considered earlier three dimensions regular four dimensions number dimensions
objectives examine hierarchical visuospatial processing children type single gene disorder associated visuospatial impairments attention deficits executive dysfunction methods used modified paradigm consisting large global shape composed smaller local shapes either congruent incongruent different global shape participants instructed name either global local shape within block reaction times interference ratios error rates children typically developing controls compared results typically developing participants demonstrated expected global processing bias evidenced vulnerability global interference local stimuli without cost global stimuli participants however experienced significant interference level local global levels stimuli conclusions findings suggest children demonstrate typical human bias processing visual information global perspective
intelligent material new marginal subject developing world today belongs research field intersection multi subjects characteristics inherent smart materials therefore important application value paper discusses concept intelligent materials two kinds new intelligent materials basic properties smart material actuator application intelligent control compared traditional materials compared smart materials exhibit superior quality
fibers covalently modified lysine pan synthesized carefully characterized critical factors affecting adsorption aqueous solution exploited initial contact time concentration temperature adsorption process strongly dependent solution excellent adsorption capacity high affinity toward process extremely rapid equilibrium reached within min thermodynamics kinetics strictly evaluated addition hypothetical adsorption mechanisms proposed moreover adsorption behavior low concentrations simulated seawater also investigated therefore pan potentially utilized efficient removal seawater elsevier rights reserved
illustrate algorithm starting image representation strictly bounded real system computes minimal balanced state variable minimal balanced state realization readily obtained algorithm stems iterative procedure compute storage function based technique solve generalization interpolation problem
need green energy increases particularly solar energy based devices become promising alternative complex costly semiconductor based photovoltaic devices major advantage based devices relatively facile fabrication thin film fairly low temperatures tunable properties chemical composition structures solvent heat treatments used processing additives deposition methods produce films different morphologies ability used organic inorganic makes useful component efficient cost effective approach harvest solar energy review presents latest approaches considerations fabrication architecture performance based solar cells various device architectures discussed effects environmental conditions performance degradation
background angioedema vascular reaction involving lower tissue causing temporary localized swelling part body many health care professionals diagnosis presents ongoing challenge several disorders manifest subcutaneous swelling assumed angioedema clinicians emergency department immunology allergy clinics skilled recognizing features angioedema differential diagnosis methods review based literature search specific indexing terms pubmed review authors clinical experience results essential diseases mimic angioedema called discussed illustrated clinical photos pointing key features help clarify diagnoses differentiate classic angioedema conclusions variety conditions cause swelling resembles angioedema potentially fatal outcome knowledge fundamental emergency setting handling patients edema kept mind assessing atypical angioedema case karger basel
current study examines lens news framing symbolic racism racial prejudice often manifests subtle symbolic racism called america supporting beliefs racial minorities gained advantage longer discriminated even counter leaders racial ethnic minority groups positions authority subject heightened visibility media ways reinforce cultural stereotypes current study uses participants experiment examine exposure positive versus negative news frames differential effects white participants symbolic beliefs priming perspective exposure negative frames likely activate underlying feelings lead biased evaluations african americans whole using path analysis present study builds causal chain relationships reveals exposure negative news frames compared positive ones activates readers anti black affect turn increases symbolic beliefs implications findings race ethnic studies political communication discussed
dietary potassium acid load reduce calcium loss bone leading beneficial effect bone mineral density nationwide korean population study dietary potassium intake associated improved bone mineral density older men postmenopausal women nutrition major modifiable factor affects bone health accompanying anion dietary potassium act alkaline source neutralizing acid load reducing calcium loss bone aimed evaluate association dietary potassium intake bone mineral density bmd korean population analyzed total men aged years postmenopausal women korean national health nutrition examination survey lumbar spine total hip femur neck bmd measured using dual energy ray absorptiometry daily food intake assessed using food frequency questionnaire divided participants based intake potassium intake highest potassium intake group showed significantly higher total hip femur neck bmd compared lower groups day across total hip day femur neck postmenopausal women highest potassium intake group showed significantly higher lumbar total hip femur neck bmd compared lower potassium intake groups day across lumbar spine day total hip day femur neck dietary potassium intake positively associated bmd men aged years postmenopausal women indicating beneficial effects dietary potassium intake bone health
smartphones become ubiquitous society large number users spending time sharing personal data devices beneficial gain understanding data security paper presents different security issues regarding applications android systems one popular mobile operating systems research also sheds light public number privacy security issues related whether additional factors play individuals understanding application framework
background interpersonal stress generation important maintaining factor major depression however little known psychological mechanisms undermine interpersonal functioning study investigated role deficits person perception regard method depressed patients healthy controls completed false recognition task measured participants tendencies make spontaneous trait inferences stis spontaneously personality traits people participants reported interpersonal daily one week following task results tendencies make stis significantly higher depressed patients particularly history childhood trauma degree participants made stis significantly related depression severity predicted occurrence interpersonal daily follow across within groups conclusions results suggest depressed patients show characteristic biases person perception contribute generation interpersonal stress
magnetic resonance accurate examination assessing activity crohns disease various indices developed purpose directly compared aim study compare diagnostic accuracy three indices detecting grading disease activity using endoscopy gold standard performed within month patients analyzed magnetic resonance index activity london indices colonic segment terminal calculated simplified endoscopy score ses considered gold standard two hundred twenty four intestinal segments included analysis according established cut points detecting active disease using london indices sensitivity index specificity respectively sensitivity detecting indices respectively specificity curve london indices detecting active disease detecting index three based indices evaluated current study high diagnostic accuracy assessment disease activity index best operational characteristics detecting disease activity also grading severity supports use clinical studies clinical practice
clinical laboratory identification underlying risk respiratory illness athletes proved problematic aim study determine whether clinical data combined immune responses standardised exercise protocols genetic cytokine polymorphism status identify risk respiratory illness symptoms cohort highly trained athletes male endurance athletes max min underwent clinical evaluation known risk factors physician comprehensive laboratory analysis immune responses rest two cycling tests min max long min intervals max intense blood tests performed determine epstein barr virus ebv status dna genotyped panel cytokine gene polymorphisms saliva collected measurement iga detection ebv dna athletes followed months self reported episodes respiratory illness confirmation underlying cause sports physician associations risk respiratory illness identified parameter assessed clinical evaluations laboratory parameters associated increased risk respiratory illnesses highly trained athletes cytokine gene polymorphisms high expression ifn gamma expression ebv dna saliva low levels salivary iga concentration genetic risk score developed cumulative number minor alleles cytokines evaluated athletes prone recurrent respiratory illness likely immune disturbances allow viral reactivation genetic predisposition pro inflammatory cytokine responses intense exercise
tracing allows analysis task interactions operating system locating performance problems trace trivial large size furthermore deep knowledge components observed system required decide whether observed behavior normal introduce framework automatically identifies differences groups task user space kernel levels many performance problems manifest variations easily identified framework comparison algorithm takes account threads affect completion time analyzed differences correlated application code facilitate correction identified problems performance characteristics task represented new data structure called enhanced calling context tree demonstrate efficiency approach presenting four case studies used uncover serious performance problems enterprise open source applications without prior knowledge also show overhead tracing solution percent depending type application
traditional training program assessment requirements evaluation criteria already meet requirements college students new era characteristics course mechanical engineering control base course abstract subject highly crossed basis study current situation college students characteristics course summary training program evaluation method course training model combining closed book exam matlab computer examination school study presented paper mode develops useful changes way students learn course simple understanding practice cognition plays certain role promoting students learning interest cultivation application ability construction knowledge system
proton induced ray emission proton induced gamma ray emission techniques employed elemental analysis twelve different plants traditionally used medicinal purposes north east india established ion beam analysis technique sensitive non destructive determination various elements atomic number greater eleven present biological samples offers complementary method determination light elements sensitivity analysis quite adequate combined together analytical techniques provide concentrations almost elements present medicinal plants quantities ppm validity techniques analyzing certified plant reference materials large number trace elements like found present studied plants variable proportions quantified percentage level elements found present parts per million levels results show many plants contain elements vital importance human metabolism prevention healing diseases
contraception followed use effective method contraception order reduce future risk unintended pregnancies provision long acting reversible contraception highly effective regard aim study compare use effective method contraception months following insertion copper intrauterine device iud intake ulipristal acetate upa emergency contraception material presenting need outpatient clinic chose either iud upa according preference follow months later telephone interviews primary outcome use effective contraceptive method month follow secondary outcomes included use effective contraceptive method months follow acceptability iud resultsa total women iud used effective contraceptive method months first visit compared women upa iud group still using iud months stated recommend iud others method women chose iud used effective method contraception month follow results study support increased use
objectives primary risk factors preterm birth feeding gut colonization unclear whether feeding colonization induce excessive expression immune genes lead using pig model hypothesized reduced gestational age immune related genes cause bacterial imbalance birth methods preterm gestation near term gestation pigs delivered section birth days infant formula bovine feeding results birth preterm delivery reduced intestinal genes related nutrient absorption innate immunity relative near term pigs whereas genes upregulated preterm birth also reduced vivo intestinal glucose leucine uptake failed increase cytokine intestinal explants relative near term birth days formula feeding incidence increased preterm versus near term pigs total genes related immunity permeability absorption decreased without affecting gram negative bacteria related responses bacterial abundance tended higher preterm versus near term pigs whereas composition unaffected conclusions preterm birth reduces nutrient absorption induce upregulation immune related genes cause bacterial neonatal period excessive inflammation bacterial occur relatively late progression preterm neonates
paper contributes better understanding installation damage geosynthetics affect soil geosynthetic interaction inclined plane shear effects installation damage induced field trials woven geotextile woven geogrid studied results indicated installation accumulation layer fine particles geosynthetic reduce skin friction available particularly sheet materials installation damage induce premature tensile failure tests along portion geosynthetic causing significant reduction corresponding coefficient interaction contribution bearing members coefficient interaction estimated using equations literature estimates installation damage induced little influence soil geosynthetic coefficient interaction inclined plane shear test different relative movements soil geosynthetic inclined plane shear deformation enabled different interface strength comparable conditions tested coefficient interaction inclined plane shear tests larger measured tests reduction factor installation damage obtained tensile tests overestimated effects installation conditions soil geosynthetic interface inclined plane shear tests
early embryonic stages modeled studies primarily human embryonic stem cells induced pluripotent stem cells analysis dna methylation however accurately reflect dna methylation levels found embryos whole genome sequencing approaches revealed presence large partially methylated domains covering genome embryos placenta contrast show abnormally high levels dna methylation compared inner cell mass placenta show dental pulp stem cells derived baby teeth cultured serum containing media mimic placental closely principal component analysis methylation patterns similar two neural stem cell types human derivation placenta human cell lines test suitability modeling epigenetic differences associated disease compared methylation patterns derived children chromosome maternal duplication controls differential methylation region analyses revealed expected control region novel genes including several autism candidate genes together data suggest useful model functional studies human neurodevelopmental disorders
introduction needle muscle biopsies used exercise years less accepted neuromuscular clinicians due size concerns methods retrospectively reviewed muscle needle biopsies done year period determine sampling success patient subject experience complications compared sample yield two different without modifications results needle biopsies adequate histology enzymology medial muscles success rate minor complication rate approximately muscle fibers submitted histologic assessment modification use needle associated larger sample size conclusions modified needle muscle biopsy technique safe provides adequate sample size histologic dna enzyme analysis muscle nerve
background early stage cerebellar hemorrhage present nausea vomiting absent neurological symptoms signs potentially leading incorrect diagnosis sought determine frequency like presentations delayed missed diagnoses among patients spontaneous cerebellar hemorrhage methods retrospective case control analysis primary cerebellar derived systematic search surgical pathology autopsy databases two large urban academic medical centers hospital visit clinical symptom data abstracted electronic paper medical records included patients delayed missed diagnoses defined least one previous visit relevant clinical symptoms days prior correct diagnosis confirmed results among records captured search filter identified cases proven primary cerebellar hemorrhage four patients initially three one hypertension small sample patients presented often normal mental state nausea vomiting although patients deteriorated clinically initial potentially dangerous diagnostic tests treatment strategies result none patients died suffered major permanent due diagnostic delay conclusions study limited small number identified cases nevertheless appears patients cerebellar present relatively clinical findings without obvious neurological manifestations individuals sometimes benign disorders initially possibly neurologic examination particularly gait testing careful search subtle cerebellar signs including limb tandem gait instability absent true cases potentially reduce
depression linked long term risk variety physical health including coronary heart disease chd little known resilience factors attenuate relationship current study assessed whether social support long term risk chd associated disorder data drawn americans changing lives study nationally representative longitudinal survey adults united states participants completed initial assessments functional social support body mass index recent history major depression chd hypertension diabetes participants assessed chd follow assessment years later social support found moderate relationship depression occurrence chd years later specifically among individuals low social support depression prospectively associated chd contrast depression prospectively associated chd among individuals high social support results indicate social support function resilience factor long term cardiovascular risk associated depression clinical interventions focusing development social support systems important addressing depression also associated long term physical health outcomes
automatic fast efficient estimation physical characteristics mass volume agricultural products improves processes sorting storage document presents computer vision system automatically estimate characteristics fruit visible aspects digital images color texture size shape correlated actual measurement defining model estimating mass volume pca principal component analysis linear discriminant analysis used like statistical data analysis ann artificial neural network estimation tool methods applied sample set consisting images fruit used training validation results greater terms correlation coefficient typical error less compared sample standard deviation two variables
individuals ultra high risk psychosis transition illness nevertheless many poor clinical outcomes impaired psychosocial functioning study used voxel based morphometry investigate baseline grey white matter brain densities identification associated functional outcome medium long term follow participants help seeking individuals underwent magnetic resonance imaging baseline functional outcome assessed average years later primary analysis showed lower baseline grey matter density white matter density bilateral frontal limbic areas left cerebellar associated poorer functional outcome social occupational functioning assessment scale findings independent transition psychosis persistence risk mental state similar regions significantly associated lower self reported levels social functioning increased negative symptoms follow exploratory analyses showed lower baseline grey matter densities middle inferior frontal significantly associated decline global assessment functioning score follow association baseline grey matter density positive symptoms current findings provide novel evidence functional outcomes lowest grey matter densities identification regardless transition status persistence risk mental state replication validation findings allow early identification poor functional outcome targeted interventions
learning program computer code considered one contemporary education benefits reach beyond skills required computing industry creativity self expression nevertheless execution computer programs usually takes place traditional desktop computer limited repertoire input output interfaces engage user hand emphasized physical representations tangible interactive objects benefit learning especially young students work explore benefits learning code ubiquitous computers robots wearable computers comparison programming desktop computer purpose thirty six students participated within groups study involved three types target computer platform desktop scratch wearable arduino robotic regardless target platform employed desktop visual programming environment scratch measured emotional engagement assessed students programming skills found students expressed positive emotions programming robotic rather desktop computer furthermore tangible computing platforms affect dramatically students performance computational thinking
automotive application strong need compact multifunctional microwave antennas example cellular phones gps usa satellite radio mutual coupling antennas leads alterations antenna pattern particular antenna satellite system accepted providers paper shown impact two phone antennas antenna reduced negligible amount
kinds internet security incidents serious malicious code increasingly serious problem caused malicious code make enterprises users suffered huge economic losses also makes network security facing serious threat paper based analysis malicious code detection technology detection system author designs implements unknown malicious code detection system based network behavior analysis test results show detection system distinguish three kinds attack produce normal alarm information achieve desired results time network behavior analysis method needs improved order achieve better analysis results provide reliable results detection system
purpose purposes study describe baseline data implementation evidence based clinical practices among health center partners part community wide teen pregnancy prevention initiative identify opportunities health center improvement methods health center partner baseline data collected first year program implementation year community wide teen pregnancy prevention initiative needs assessment health center capacity implementation evidence based clinical practices administered health centers partners communities united states high rates teen pregnancy results health centers reported inconsistent implementation evidence based clinical practices providing reproductive health services adolescents approximately offered day infrastructure reduce cost barriers offered school prescribed hormonal contraception without prerequisite examinations testing approximately three provided visual audio privacy examination rooms counseling areas fewer offered wide range contraceptive methods took sexual health history every visit reported quick start initiation hormonal contraception emergency contraception intrauterine devices always available adolescents conclusions assessment highlighted opportunities health center improvement strategies build capacity health center partners implement evidence based clinical practices lead accessibility quality reproductive health services adolescents funded communities published elsevier inc behalf society adolescent health medicine
purpose risk problematic internet use associated impairment multiple domains including psychopathology present study examined relationship disordered eating large community sample methods participants completed online survey health behaviors two thresholds disordered eating examined results sub subthreshold eating disorders groups reported greater depressive symptoms poorer self control control group sub group reported greater impulsivity control group sub groups significantly differed key features related condition finally occurrence sub associated greater depression second set analyses based stringent thresholds problematic internet use groups differed measures compared control group groups also differed key features related condition differ measures impulsivity self control occurrence associated greater depressive symptoms either independently conclusions sub share links depression poor self control represent possible therapeutic targets across internet use disordered eating behaviors occurring either stringent thresholds associated greater depression future studies examine temporal nature associations extent targeting depression internet use disordered eating lead improvements across domains elsevier ltd rights reserved
research treatment nervous system challenged many physiological barriers major cns protected blood brain barrier limits surgical therapeutic diagnostic interventions hostile environment created reactive astrocytes cns along limited regeneration capacity makes functional recovery tissue damage difficult inefficient nanomaterials unique ability interface neural tissue nano scale capable influencing function single neuron ability nanoparticles surface modifications exploited various neuro imaging techniques targeted drug delivery tunable topography provides accurate spatio temporal guidance review attempt progress understanding obstacles posed complex physiology nervous system innovations design fabrication advanced nanomaterials drawing natural phenomenon also discuss development nanomaterials use neuro diagnostics fabrication advanced nano devices use electronic electrophysiological applications energy efficient parallel computing ability human brain inspired design advanced nanotechnology based computational systems however extensive use nanomaterials neuroscience also raises serious toxicity issues ethical concerns regarding nano implants brain conclusion summarize challenges provide insight huge potential nanotechnology platforms neuroscience elsevier ltd rights reserved
voltage gated sodium channel channel antagonist inhibits arginine release isolated rat far uncertain whether direct action ectopic producing neuroendocrine tumors studied effect release terminal fragment pro expression gene human small cell lung cancer cell line cells maintained medium fetal bovine serum used within fifth passage detected using new sandwich immunoassay mrna levels measured using real time reverse transcription polymerase chain reaction treatment concentration inhibitory effect levels medium concentration mrna levels cells also decreased although sodium challenge added sodium increased levels medium sodium challenge added sodium effect mrna levels concentration suppressed levels medium sodium challenge added sodium concentration also decreased mrna levels cells sodium challenge added sodium among five tested channel subunits highly expressed cells however significantly decreased mrna levels sodium challenge added sodium results suggest cells sensitive sodium control release gene expression direct action ectopic producing tumors suggesting importance channels producing neuroendocrine tumors
principal component analysis widely used various fields research bioinformatics medical statistics etc especially high dimensional data analysis although crucial components selection vital matter principal components analysis relatively little attention paid issue existing studies principal component analysis based hoc methods method cumulative percent variance average eigenvalue propose novel method selecting principal component based type regularized regression modeling order effectively perform principal component regression consider adaptive type penalty based singular values components propose adaptive principal component regression proposed method perform feature selection incorporating explanation power components high dimensional predictor variables also response variable sparse regression modeling choosing regularization parameter crucial issue since feature selection estimation heavily depend selected regularization parameter derive model selection criterion choosing regularization parameter proposed adaptive type regularization method line generalized information criterion monte carlo simulations real data analysis demonstrate proposed modeling strategies outperform principal component regression modeling
comprehensive birds view research note combines state art brief presentation history original solutions position like views prospective future developments one relevant interesting areas related use fuzzy logic database management systems notably querying component extent broader issue data information management briefly summarize roots new applications fuzzy logic relevant proposals development context basic relational database model particularly focus fuzzy querying human consistent friendly way retrieving information due real human intentions preferences expressed natural language represented via fuzzy logic possibility theory extensions notably fuzzy queries linguistic point close relation linguistic newer prospective developments mainly focus bipolar queries users intentions preferences involving sort required desired mandatory optional etc conditions show various ways handling queries conclude brief position statements view relevant promising directions challenges elsevier rights reserved
study proposes adaptive neuro fuzzy inference system based rotor position controller brushless direct current motors improve control performance drive transient steady state conditions dynamic response motor proposed controller considered standard reference input effectiveness proposed controller compared proportional integral derivative pid controller fuzzy pid controller proposed controller solves problem nonlinearities uncertainties caused reference input changes motors guarantees fast accurate dynamic response outstanding steady state performance furthermore controller provides low torque high starting torque detailed study includes matlab based simulation experimental prototype illustrate feasibility proposed topology
department health england developed framework comprising criteria health services seeing year olds improve quality coverage reduce access date however criteria considered within community pharmacy service development policy aim article assess relevance criteria community pharmacy examine ways currently met met guide future service development methodsthe project employed three methods checklist guided observations face face semistructured interviews staff members undertaken eight community across england selected known focus provision young peoples services complemented cross sectional online survey completion pharmacy staff across wider range recruited targeted local pharmaceutical study instruments designed gather information relevant criteria key took part observations interviews six online survey link website returned respondents results demonstrate applicability criteria community pharmacy services highlighting particular strengths community pharmacy services young people accessibility opportunities priorities service development meet specific needs staff training engagement integration local service provision conclusionsthe criteria applied community pharmacy services without adaptation providing appropriate framework guide service development promote young people friendly pharmacy services
study concerned china offers perhaps compelling evidence regarding womens involvement chinas reform womens provide rare emotions understanding roles identities meanings taking examine author challenges gender role household responsibilities male responding political due outer world disrupted womens challenge persistence ideology also illustrate distinction womens conception social reality thus study suggests ongoing consistent effort limits womens space results construction separate space private public domains represents arena public space private space overlap words managed space functions public domain writing immediate experience chaotic times womens writing reflects transformation definition one often recognized sometimes neglected paper understanding gender roles literature promotes alternative strategy reading womens literature
purpose productivity worldwide problem efforts made last three decades explore ways increase rate productivity construction sites purpose paper investigate state art productivity research present findings survey factors impair productivity site design methodology approach literature review structured five general pre construction activities activities construction managerial leadership issues motivational factors organizational factors total determinants extracted assessed main contractors findings literature review revealed advancement developing techniques tools improving productivity site need done technology innovation interview survey indicated factors associated pre construction activities namely experience selected site project managers design errors design project planning communication leadership style procurement method critical factors influencing site productivity highly ranked factors material work environment research limitations implications survey based main contractors thus generalized cover sectors building team designers engineers practical implications outcome research used provide professionals contractors guidance acting upon controlling significant factors perceived influence construction labor productivity site originality value first reviewed state art trends construction productivity research second primary survey industry experts rank relative importance factors influence site
automated systems based programmable logic controllers still applied discrete event systems des controlling monitoring industrial processes signals based control systems characterized physical input output signals coming going sensors actuators respectively direct contact production manufacturing process input subsystem consists sensor physical inputs module present two kinds faults short circuit open circuit one signals process physical inputs causes faults control control algorithms behavior diagram one five programming languages supported international commission iec iec standard remains used industry control algorithm design based systems paper proposes simulation validation control algorithms developed using nets order deal possible fault options short circuit open circuit physical inputs subsystem based control system one control algorithms analyzed order show advantages proposed approach
manufacturing engineering especially machining process definition reference plane first essential step within overall process reference plane applied component features processed reference basic plane process component order resist processing forces several systems available pneumatic magnetic systems magneto rheological systems depending stiffness component deformed due forces stresses introduced effect neglected components high stiffness nearly rigid body behaviour however deformation low components forces sheet metals relatively large range addressed accuracy machining process due introduced elastic stresses component phenomenon known focus work design system flexible bodies order reduce enable high precision processing system consists set supports adjust surface body without introducing stresses causing machining process number arrangement supports optimized function intensity position milling force geometrical mechanical properties body functional unit system cylindrical nearly within pipe numerical simulation used configuration optimization developed systems also used process shaped bodies
given growing number mobile devices researchers pointed distributed computing environments clusters even computational grids increase available resources scavenging devices capabilities however negatively impacts batteries study centralized job aim exploiting clusters mobile resources rather stable devices terms connection time outperform previous centralized jobs amount energy also show perform compared based job difficult implement consume network resources hence energy elsevier rights reserved
guidelines exist regarding management early effects radiotherapy preventive curative care strategies adapted aim delay limit complications improve patients comfort prevention involves encouraging patients take care skin avoid moisture sun dry rules seem insufficient products solution cream prescribed according individual risk patient preventive measures appears topics indicated wound healing applied care education observation needs multidisciplinary approach improvements radiotherapy treatments methods techniques effective evolution published elsevier masson sas rights reserved
internal combustion engines inherently demand assistance perform autonomous functioning nevertheless common solution one century electric motor diesel cycles dynamic coupling system defined herein mechanical connection internal combustion engine motor evolved considerably since intermittent ring gear interface adopted paper reviews conceptual design behind starting systems developed far focusing functional analysis proposes innovative concept preliminary study dynamic simulation using lumped parameters model implemented also discussed potential aid proposed design based decision matrix method possible evaluate proposed design state art promising alternatives find real cost effective alternative existing concepts couple electric motor internal combustion engine dynamic coupling system proposed herein demonstrates potential evolve cost effective solution implement start stop systems worldwide contributing reduction pollution caused automotive vehicle emissions
human mitochondrial long noncoding rnas described date analysis deep sequencing data identified three generated mitochondrial genome confirmed expression northern blotting strand specific qrt pcr show abundance comparable complementary mrnas nuclear encoded mitochondrial proteins involved rna processing regulate expression also identify transcript ends three show mitochondrial protein important processing transcripts finally show mitochondrial form abundance cell tissue specific suggesting functional role regulation mitochondrial gene expression
servo velocity sensors provide reliable accurate velocity acceleration measurements civil infrastructures bridges buildings however communicate data processing unit cable time continuous monitoring applications using study integrated converter module designed implemented bridge wireless sensor networks wsn proposed wsn enabled verified comparing measured results commercial system bridge experiment applied bridge vibration measurement employed suspension bridge vibration test several guidelines deployment installation wsn enabled vibration monitoring application carefully addressed suggested optimized deployment scheme reduce packet loss efficiently wsn enabled applied continuous monitoring applications
estimated youth primary care exhibit behavioral symptoms identify risk base symptoms alone irrespective functional impairment address issue pediatric symptom checklist widely used symptom combined functional impairment current behavioral services enrollment items form pediatric behavioral health screen assessed compared full child behavior checklist total youth years age administered areas receiver operating curves approached exceeded analyses reflecting excellent classification accuracy almost false observed among currently untreated cases functional impairment differential item functioning found performance pediatric primary care behavioral health supported previous research additional functional impairment items form appeared useful particularly interpreting borderline range scores
analyze large scale real world data various attributes many real world data network traffic logs web data social networks knowledge bases sensor streams multiple attributes represented multi dimensional arrays called analyzing tensor tensor widely used many data mining applications detecting malicious attackers network traffic logs source destination port number finding phone call history receiver date identifying interesting concepts knowledge base subject object relation however current tensor decomposition methods scale large sparse real world millions columns fibers paper propose distributed method large scale tensor runs mapreduce framework careful design implementation dramatically reduce size intermediate data number jobs leading achieve high scalability compared state art method thanks analyze big real world sparse handled current state art discover hidden concepts
compelling evidence gender differences self esteem mental disorders found psychology literature however researchers yet identified etiologies perspective proposes gender discrimination contributes differences promotes internalized male superiority enhanced self esteem increase impact mens behavior promotes internalized gender women decreased self esteem predicting internalizing disorders samples sample women sample men using path analysis tested perspective mens sample externalizing accounted variance predicted internalized male superiority increased externalizing addiction decreased internalizing womens sample predicted increased internalized female internalizing lowered self esteem internalizing accounted variance results identified etiologies dynamics contribute gender differences discussed implications findings gender equality
monoamine oxidase gene important candidate gene human behavior encodes enzyme regulating metabolism key neurotransmitters regulatory mechanisms gene dogs yet elucidated measured gene transcription analyzed genotype methylation status gene promoter region different dog determine whether expression correlated genotype epigenetic modification dogs found brain specific expression gene different transcription levels different dog including german also robust association dna methylation gene promoter mrna levels however tandem repeats observed near transcription start site variable indicating correlation canine activity results show differential dna methylation promoter region affect gene expression modulating promoter activity moreover distinctive patterns expression dna methylation involved breed specific individual behavioral characteristics aggression behavioral phenotypes related different physiological neuroendocrine responses elsevier rights reserved
oral squamous cell carcinoma aggressive cancer associated high recurrence metastasis poor treatment outcome dysregulation long non coding rnas shown promote tumor growth metastasis several cancers study investigated expression selected long non coding rnas associated cell proliferation metastasis tumor suppression oral squamous cell carcinomas normal tissues quantitative real time polymerase chain reaction long non coding rnas significantly overexpressed tumors tobacco history moreover long non coding rna profile similar head neck cancer datasets cancer genome atlas database regulator reprogramming implicated tumorigenesis found overexpressed undifferentiated tumors showed strong association tumor recurrence poor therapeutic response oral squamous cell carcinomas first time observed overexpression downregulation mir overexpression myc suggesting existence mediated competing endogenous rna network undifferentiated tumors taken together study demonstrated association overexpression undifferentiated oral tumors prognostic value predict therapeutic response
individuals apply different processing strategies deal situations encounter one central question social cognition research refers factors determine reliance different processing strategies functional perspective holds processing strategies need adjusted requirements situation argue individuals mood carries information benign versus problematic nature situation thus mood regulate cognitive processing focusing mental abstraction propose positive mood contributes processing style characterized reliance prior knowledge form general knowledge structures whereas negative mood processing style characterized attention details consideration new situation specific information
allergic rhinitis long considered predominantly involve actions cells relatively small contributions cells recent years discovery regulatory treg cells rendered balance paradigm complex expanded understanding pathogenesis key cytokine produced cells known induce allergen specific cell activation neutrophil accumulation serum ige production asthma features play important roles best knowledge studies assessed feasibility using antagonists treat thus principal objectives present study first determine status treg cells nasal mucosa mouse model second investigate effects cells therapeutic efficacy anti antibodies context anti given challenge balb mice induced measured numbers nasal motions neutrophil levels treg parameters nasal mucosa anti markedly reduced number nasal motions decreased neutrophil infiltration reduced responses increased treg response anti treatment protects results improve understanding pathogenesis lead development novel therapeutic approaches management condition
deterministic boltzmann model equation solver called developed framework open source cfd toolbox solver adopts discrete unified gas kinetic scheme collision model validated simulating several test cases covering different flow regimes including one dimensional shock tube problem two dimensional thermal induced flow three dimensional driven cavity flow solver features parallel computing ability based velocity space decomposition different physical space decomposition based approach provided framework two decomposition approaches compared two three dimensional cases parallel performance improves significantly using newly implemented approach speed two orders magnitudes observed using cores small cluster program summary program title program files doi http licensing provisions license programming language external routines libraries http nature problem solving boltzmann equation model explicitly solution method discrete unified gas kinetic scheme restrictions symmetric boundary condition applied walls parallel axis directions elsevier rights reserved
ethylene refrigeration system light production plant investigated using conventional advanced analyses advanced analysis investment exergy destruction costs system components divided endogenous exogenous unavoidable parts improve knowledge refrigeration system results analysis represent total cost column compressor compressor multi stream heat exchanger larger components results advanced analysis reveal total costs components endogenous reduced column compressor increasing efficiency two components investment exergy destruction costs decreased large amounts endogenous exergy destruction cost components represent interactions components main reason exergy destruction therefore appropriate strategy enhancement system efficiency improve performance based results column compressor highest priority improve performance sensitivity analysis parameters important operating variables also investigated elsevier ltd rights reserved
algorithms extracting hydrologic features properties digital elevation models challenged large datasets often fit within computers ram depression filling important step many algorithms present new linearly scaling algorithm priority flood depression filling algorithm using single multi consumer design new algorithm works equally one core multiple cores multiple machines take advantage large memories cope small ones unlike previous algorithms new algorithm guarantees fixed number memory access communication events per comparison testing results new algorithm running generally faster using fewer resources previous algorithms moderately sized algorithm exhibits similar strong weak scaling efficiencies cores linear time scaling across datasets ranging three orders magnitude largest dataset run algorithm cells cores processing required wall time compute days test three orders magnitude larger previously performed literature complete source code correctness tests available repository elsevier ltd rights reserved
present work investigated biochemical thermo kinetic stability immobilized polymeric material immobilization lipase candida carried blend poly alcohol chitosan support via cross linking method produce robust immobilized characterized various physico biochemical characterization techniques later thermal solvent stability polymer immobilized lipase determined term half life time values enthalpy delta degrees entropy delta degrees free energy delta degrees different temperatures various solvents thermodynamic stability trend found cross linked lipase lipase free lipase moreover kinetic parameters max catalytic efficiency also determined understand kinetic features polymer immobilized enzyme investigate economic viability developed
objective purpose study examine associations sleep disturbances pregnancy delivery preterm birth methods prospective study healthy women pregnancy selected three hospitals china self report questionnaires including sleep quantity quality exercise habits recent month administered weeks gestation data type delivery gestational age neonates weight recorded delivery controlling potential confounders serial multi factor logistic regression models performed evaluate whether sleep quality quantity associated delivery preterm birth results women delivered preterm women poor sleep quality first second third trimester high risk delivery women poor sleep quality second third trimester short sleep time third trimester high risk preterm birth conclusions sleep disturbances associated increased risk delivery preterm birth throughout pregnancy obstetric care providers women childbearing age practice healthy sleep hygiene measures
aim established treatment complicated refractory ulcerative colitis laparoscopic approach offers potentially improved outcomes aim study report experience single large centre method january consecutive patients undergoing retrospectively analysed prospectively managed database patients known crohns disease undergoing one stage procedures excluded demographics perioperative outcomes second stage procedures analysed results study period performed emergency elective acute severe colitis refractory therapy common indication overall laparoscopic open performed conversion rate mortality morbidity rates respectively whilst operative time shorter open min fewer complications shorter hospital stay days following laparoscopic fewer complications shorter hospital stay also observed elective patients undergoing laparoscopic likely undergo second stage procedure open conclusion laparoscopic feasible safe even emergency situation laparoscopic approach offer advantages terms lower morbidity reduced length stay elective resection offer similar advantages best performed whenever possible
experiment start physics data taking factory search new physics beyond standard model physics channels data acquisition system consists large number subsystems handle high trigger rate huge data bandwidth subsystem considered network accessible component distributed control network software control monitoring system experiment newly developed manage data flow subsystems slow control system handles operations subsystems including parameter management relational databases data quality monitor system analyzes event sample online data flow monitor status detector data taking graphical user interfaces also developed software systems report designs slow control system results operation beam test prototypes detector components test beam facility january
intestinal responsible infections various hosts including humans several wild domestic animals studies correlated environmental contamination clinical infections region aim study compare groups clinical environmental sources population genetic analyses verify haplotype sharing degree genetic similarity among populations clinical environmental sources metropolitan region results showed high diversity haplotypes substantial genetic similarity clinical environmental groups demonstrated sharing genotypes among different populations studied comparison veterinary human sequences led identify new genotypes including human isolates genetic application population genetic analysis epidemiological studies allows quantification degree genetic similarity among populations different sources contamination genetic similarity isolates among human veterinary environmental groups reinforced correlation clinical environmental isolates region great importance public health
background long term consequences cancer treatments young women especially fertility issues gaining attention survival rates increase breast cancer frequent malignancy women reproductive age aim purpose review describe serum anti hormone level diagnosis evolution chemotherapy women reproductive age treated breast cancer second impact association comparison hormonal markers ovarian reserve studied methods systematic pubmed search conducted articles published april related women suffering breast cancer using following key words inhibiting substance ovarian reserve ovarian function breast cancer ovarian toxicity chemotherapy menopause results levels rapidly fall undetectable levels women chemotherapy generally persist low levels women treatment seem impact negatively ovarian function data ovarian reserve scarce predictor occurrence chemotherapy related relevant hormonal marker ovarian reserve conclusion serum relevant tool ovarian reserve assessment follow treatment premenopausal women breast cancer large prospective studies necessary determine predictive interest post treatment residual fertility eventually use fertility preservation counseling treatment initiation elsevier ltd rights reserved
constructing structures receiving high vertical horizontal force port facilities soft ground sea important increase strength ground inhibit excessive settlement recently numerous studies method outer wall granular geotextile geogrid certain level tensile strength since geotextile increases strength granular confinement effects confined granular advantages conventional sand terms bearing capacity settlement furthermore method consumes less aggregate compared conventional sand gravel method study proposed determine characteristics mechanical behaviors bearing capacity stress concentration ratio composite ground improved using reinforced geotextile geotextile sand alternative conventional method purpose several loading tests conducted artificially clay grounds reinforced using conventional geotextiles three different tensile strengths various replacement ratios based results study bearing capacity soft clay ground reinforced larger soft ground reinforced conventional failure mode different tensile strength geotextile little effect bearing capacity failure
insulin pump therapy subcutaneous insulin pump therapy currently physiological form insulin delivery patients type diabetes benefit improvement levels type reduced rate reduced glucose fluctuations thereby improved glucose control reduce risk long term diabetic complications sensor augmented pump therapy optimal basis used combination continuous glucose monitoring systems sensor augmented pump therapy relevant first step towards soon available closed loop system artificial pancreas
group delay engineered transmission line two port pass network analog signal processing applications presented analytically modeled experimentally demonstrated network consists cascaded sections distributed implementations lumped circuit obtained alternate ports adjacent lines port coupled transmission line network transmission line sections modeled using transmission line theory per unit length capacitance matrix inductance matrix allowing different sections network exhibit different lengths generalized group delay engineering procedure proposed quasi arbitrary group delay responses achieved combining group delay responses sections different lengths computer design approach based genetic algorithms applied synthesis consists determining structural parameters different section groups using approach networks group delay engineered edge coupled technology gaussian linear quadratic group delay responses realized theoretical results validated experiment finally two application examples analog signal processing tunable impulse delay line real time frequency using proposed dispersive pass networks presented
cocaine addiction chronic persistent become major social health problem many countries existing studies shown cocaine often undergo episodic periods addiction moderate dependence cocaine given reversible feature cocaine use formulated stochastic process one state another impacts various factors treatment received individuals psychological problems cocaine use vary across states article develops hidden markov latent variable model study multivariate longitudinal data concerning cocaine use california civil program proposed model conventional latent variable models allow bidirectional transition cocaine addiction states conventional hidden markov models allow latent variables dynamic develop maximum likelihood approach along monte carlo expectation conditional maximization algorithm conduct parameter estimation asymptotic properties parameter estimates statistics testing heterogeneity model parameters investigated finite sample performance proposed methodology demonstrated simulation studies application cocaine use study provides insights prevention cocaine use
herein report synthesis activity enzyme directed immune cell activation mediated either added melanoma cells covalent attachment position critical activity resulted pro selectively converted active pro exhibited directed immune cell activation measured transcription raw blue macrophages cytokine production tnf monocytes conversion pro active also found occur using enriched melanoma cells culture experiments either immune cell line enriched cells activation immune cells
early prediction success green building projects important challenging issue aim study develop model predict cost schedule performance green building projects based level definition pre project planning phase end three step process proposed pre processing variable selection prediction model construction data certified green buildings used develop models balancing data set respect proportion cases outcome categories pre processing number input variables reduced cost schedule performance prediction respectively using variable selection method cost schedule performance prediction models constructed using selected variables four different classifiers support vector machine svm back propagation neural network decision tree algorithm logistic regression classification performance four models compared assess applicability svm models exhibited highest accuracy sensitivity specificity predicting cost schedule performance green building projects results study empirically validated cost schedule performance green building projects highly dependent quality definition pre project planning phase elsevier ltd rights reserved
multiple proteases system target substrates recent evidence indicates proteases degrade proteases hydrolysis one example interactions directional change expected kinetics explore potential protease protease interactions silico program developed users input two proteases protease substrate protease program identifies putative sites substrate protease highly susceptible cleavage protease using sliding window approach scores amino acid sequences preference protease active site database call protease cleavage analyzed specificities test validate algorithm cumulative likelihood scoring identified sites subject hydrolysis mutations made locations tested block hydrolysis validate predictions mutants significantly reduced hydrolysis validating unbiased identification sites protease interactions mmp mmp tested predictions confirming utility systems unique compared putative site cleavage programs allowing users define proteases interest target also employed non protease substrate proteins short peptide sequences
objective effective treatment schizophrenia requires continuous antipsychotic maintenance therapy however poor persistence treatment common among patients schizophrenia objective study compare persistence hospitalization rates among patients schizophrenia treated long acting antipsychotics enrolled patient information program program cohort patients treated oral antipsychotics enrolled patient information program cohort research design methods using quasi experimental design data chart reviews program patients medicaid claims patients analyzed patients eligible months pre index data months post index data hospitalization index main outcome measures persistence hospitalization rates assessed months post index propensity score matching used control observed differences demographics baseline clinical characteristics odds ratios ors calculated using generalized estimating equation models adjusted matched pairs propensity score results total program patients matched patients similar baseline characteristics adjusted ors indicated persistence rate months significantly higher program cohort versus cohort month post index hospitalization rate program cohort significantly lower versus cohort adjustments limitations data program patients two different independent data sources healthcare claims chart reviews respectively results based relatively small number program patients conclusion program patients treated antipsychotics higher persistence rates significantly lower adjusted hospitalization rates compared patients treated
insomnia common among elderly people nearly adult population also suffer insomnia pharmacological treatment insomnia include use non drugs like although drugs improve sleep usage also associated number adverse effects melatonin hormone secreted gland animals human beings used treatment since timing secretion humans animals increase nocturnal sleep propensity short half life melatonin slow release preparations introduced treatment insomnia recently selective receptor agonist greater efficacy action treating insomnia used clinically found effective improving sleep quality sleep efficacy also reducing sleep onset time compared melatonin slow melatonin preparations mechanism action improving sleep discussed paper another drug besides acting receptors also displays drug found effective novel antidepressant treating major depressive disorders besides causing remission depressive symptoms also improves sleep quality efficiency antidepressants clinical use today improve sleep drugs like deserve special attention treatment insomnia sleep disturbances associated depressive disorders promising role treatment sleep disorders
dietary fibre represents wide spectrum escape digestion human gastrointestinal tract term widely associated positive health outcomes fibre content food products potential basis nutritional composition claims many parts world current review aims evaluate current evidence human trials impact fibre rich foods isolated dietary fibre body weight management evidence observational studies consistently demonstrates habitual increased intake fruits vegetables whole grains associated lower body weight increase time adherence healthier dietary templates including incorporation higher amounts plant based foods intervention studies also tend evidence greater weight loss control diets highlights importance fruits vegetables whole grains foundation positive dietary habit contrast randomised controlled trials based increase fruit vegetable food intake alone tend show impact body weight body fat outcomes suggesting either length previous studies long enough observe measurable effects dietary changes alone benefit outcomes individual intervention studies suggest potential benefits fibre isolates weight loss appears reproducible evidence efficacy limited amount available evidence suggests need designed appropriately targeted intervention studies future elsevier ltd rights reserved
differential effective tool modern differential chain markov cipher forms markov chain second largest eigenvalue sle transition matrix determines number iterations markov cipher resist differential owing huge scale transition matrix compute sle thus estimation method desirable find two methods estimate sle using elements row stochastic matrix literature advantage parallel computing without generating complete matrix apply two methods transition matrix international data encryption algorithm investigate accuracy estimation international data encryption algorithm primitive markov cipher transition matrix converge uniform distribution use power initial transition matrix estimate sle different number rounds compare results errors estimation acceptable several rounds less zero elements transition matrix distribution uniform moreover present simple relation sle number iterations markov cipher requires differential show necessary condition matrix decomposition method copyright john wiley sons ltd
infrastructure sustainability become major global concern massive reservoir seriously disrupted service many reservoirs worldwide difficult high water content soft nature study explores novel approach using produce controlled low strength materials reinforced used storage applications test results shown initially provided significant contribution strength improvement based however effective reinforcement appears highly dependent upon type geotextile original strength results show promising solution reservoir ensuring sustainable approach mitigation reservoir
background transcription factor essential stages cell development including transcription factors activate expression key myelin genes cells therefore context dependent pro transcription factor identification genes regulated provide insight cell biology related diseases genome wide studies successfully revealed target genes efforts mainly focused stages cell development propose less biased approaches reveal novel functions outside results developed stringent computational based screen genome wide identification response elements experimental validation pilot set predicted binding sites multiple systems revealed directly regulates previously alternative promoter encodes transcription factor inhibits glial cell differentiation explored utility computational approach combining seq analysis cultured cells previously published chip seq data rat nerve remarkably analysis enriched genomic segments map loci involved negative regulation including functional studies cells revealed eight loci expressed prior regulated subsequent seven eight loci validated binding sites seven eight loci regulated upon function conclusions computational strategy revealed putative novel function cells suggests model activates expression genes inhibit non stages cell development importantly computational functional datasets present valuable study transcriptional regulation protein function glial cell biology
working day weather passive wave widely used civil military get specific information material characteristics different radar infrared detectors basis operating range equation radiation cross section stealth effect metal objects presented near sensing application measurement experiments metal solid models adopts band outdoor calibration system temperature different surface metal objects also measured experiments results show temperature contrasts solid models remarkable difference bare coated conditions operating range decrease addition stealth methods different surface treatment respectively reduce antenna temperature contrast degree
one major etiological agents human hand foot mouth disease worldwide infection young children people immunodeficiency causes severe symptoms high rates however still approved drugs treat infections based previous report peptide anti protease present highly specific hydroxy derivative inhibited proliferation multiple strains various cells low cytotoxicity hydroxy covalent conferred high potency selectivity interact cysteine residue active site viral protease also documented resistance mutation pro combination polymerase entry inhibitors produced strong synergistic antiviral effects collectively findings suggest compounds potentially developed drugs treatment published elsevier
rainwater harvesting small scale enhances food self overcome rural poverty far rainwater harvesting encouraged national water supply policy supported government study proposes two rainwater harvesting facilities one rain household roofs tank storage second rain pond roof pond storage aim paper assess benefits rainwater harvesting based propose policy implications government investigate benefits rainwater harvesting literature review cost benefit analysis monitoring project pilot plants comparison existing irrigation drinking water infrastructure results indicate rainwater harvesting offers numerous benefits technological economic environmental social terms facilities positive net present value favourable circumstances however material investment costs pose problem recommend government rainwater harvesting infrastructure operation maintenance costs integrating aspects national rainwater harvesting policy create conditions achieve benefits scale rainwater harvesting based
pair programming software development technique introduced part extreme programming pair programming two developers share computer work together developing one piece code test pair programming effects students behavior performance middle eastern society interaction restrictions found devised experiment carried entire academic year consists two experiment targeted two sections per semester advanced computer programming course students one sections worked pairs lab sessions applying pair programming rules techniques section students worked individually norm programming labs video recordings recorded throughout lab sessions studied analyzed addition code samples collected students study effect pair programming students code quality experiment found pair programming potential increase students confidence enjoyment course improved courses completion rate addition students pair programming sections showed able individually produce code better quality students traditional section
conditional established using linear series training structure shown previous study intact unreinforced trials assessing performance presented among stimulus equivalence test trials defined correct performance trials seen participants responding accordance stimulus equivalence participants goal current study investigate status previously trained relations time stimulus equivalence tests contexts experiment investigated following many one conditional discrimination training adult participants defined correct performance probes trained relations observed participants formed stimulus equivalence classes participants responding accordance stimulus equivalence experiment adult participants received linear series many one one many conditional discrimination training tests stimulus equivalence training trials subsequently participants experienced three additional tests derived trained performance within month original training continued testing passage time little effect stability learned derived performance participants initially responding accordance stimulus equivalence participants failed form stimulus equivalence classes initial test responded line trained relations displayed varied performance time results experiments indicate lack stimulus equivalence performance commonly caused breakdown trained relations time stimulus equivalence test
background aimed evaluate effect week intervention shoulder spinal actions women breast cancer related arm method randomised controlled pilot trial intervention group completed eight weeks daily sessions control group continued best current care including information compression skin care risks temperature variations recommended safe use affected arm pelvic posture range motion shoulder spine strength shoulder major minor anterior taken baseline week week follow outcome blinded allocation results week eight intervention group improvement pelvic posture indicated reduction pelvic compared control group mean difference degrees degrees secondary finding strength shoulder significantly increased following intervention affected non affected arm significant group changes measures result intervention conclusion pilot study demonstrates participation provide benefits posture strength women breast cancer related improvements attributed focus overall postural functional movement patterns trials longer intervention follow methodology warranted
analysis quality investments part decision making implementing rainwater harvesting systems order evaluate whether investments environmental impacts mitigation also attractive point view considering flow methods net present value best indicator analysis allows deciding best two mutually exclusive projects also presents simple calculation routine easily understood users work aimed presenting decision making analysis tool rainwater harvesting systems based maximization net present value using particles swarm optimization technique decision tool used evaluate quality investments implementing rainwater harvesting system considering building public category three scenarios water considered current rate structure increases scenarios two alternatives sewage rate corresponding rainwater use fee results illustrate opportunities investments rainwater harvesting systems
work presents procedure design analysis linear tubular switched reluctance generator wave energy conversion generator meant applied direct drive wave energy converter namely point absorber device modeled according wave climate conditions site portuguese coast procedure starts statistical analysis local random ocean behavior order determine likely values occurrence wave parameters question based generator analytically designed proper dimensions calculated numerical simulation performed magnetic flux path density values determined
paper argues research field artificial intelligence education benefit integrating recent technological advances wearable devices big data processing modelling printing ambient intelligence design methodologies developing systems address learning domain particular acquisition motor skills benefit individualized instruction support just cognitive skills learning last decades point procedural learning considered since earliest days dating back however developments motor skills learning lagged significantly behind technology evolved supported quantified self movements now possible integrate emerging interactive technologies order provide personal awareness reflection behavioural change low cost low intrusion many activities exist benefit motor skills learning playing instrument drawing training surgery improving technique sports arts learning sign language etc context suggestions research coming years focus addressing challenges regarding modelling interaction providing appropriate personalized support
sleep characteristics military veterans active duty service members ptsd without ptsd recent analyzed determine combat deployment associated sleep restriction alternative explanation sleep complaints found among combat veterans ptsd determined ptsd checklist military version scores week period sleep data collected using sleep actigraphy self report across entire sample subjective objective assessment methods sleep strongly correlated although notable within group differences specifically although sleep duration groups differ based actigraphy veterans without ptsd reported sleeping min longer veterans ptsd effort determine individuals without ptsd sleep found symptoms emotional arousal anger anxiety significantly correlated self reported sleep duration suggesting pattern higher autonomic arousal found veterans ptsd thus although sleeping higher levels emotional arousal reported veterans ptsd mean perceive sleep research necessary determine sleep architecture veterans ptsd actually different combat veterans without ptsd differences actually amenable standard behavioral treatments disorder
human gamma delta cells display potent responses pathogens malignancies particular interest expressing gamma delta cell receptor tcr incorporating tcr delta chain variable region delta activated pathogen derived host derived accumulate transformed cells cells exposed activated delta cells exhibit multiple effector functions made attractive candidates immunotherapy despite clinical trials reported mixed patient responses highlighting need better understanding delta cell biology reveal previously functional heterogeneity delta cell compartments healthy individuals cohort identify distinct delta profiles stable time correlate age gender history activation develop leaving thymus multiple analyses suggest delta profiles consist variable proportions two dominant contrasting delta cell subsets divergent transcriptional programs display mechanistically distinct cytotoxic potentials importantly individuals delta profile predicts defined effector capacities demonstrated contrasting mechanisms efficiencies killing range tumor cell lines short data support patient stratification identify individuals delta profiles effector mechanisms compatible tumor killing suggest tailored delta profile specific activation protocols maximize chances future treatment success
background assessment affective provided useful insights psychopathological understanding affective disorders conceptualization bipolar spectrum disorders temperament san instrument widely used research yet psychometric properties optimal factor structure unclear methods pubmed medline psycinfo embase electronic databases searched inception march validation peer reviewed studies different versions performed adult samples considered inclusion results twenty seven studies met inclusion criteria several versions validated languages across countries item self reported version studied version studies supported five factor solution although studies performed confirmatory factor analyses five factor solution consistently reported item version overall evidence indicates different versions adequate internal consistency reliability version acceptable test retest reliability methodological quality included studies varied limitations meta analysis performed due heterogeneity settings versions utilized conclusions different versions validated across different cultures short item version holds promise merits investigation culture bound factors influence expression assessment affective
background cancer skeletal muscle related poor survival study quantitative body composition measurements using computed tomography investigated relation survival post operative complications surgical site infections surgical patients cancer head pancreas methods prospective cohort patients cancer head pancreas analysed imaging level determine muscle radiation attenuation average units total skeletal muscle visceral adipose tissue area iii subcutaneous adipose tissue area adipose tissue area skeletal muscle area sex specific cut offs determined lower muscle radiation attenuation skeletal muscle area higher adipose tissues variables body composition related overall survival severe post operative complications surgical site infections wounds daily independent trial nurse using cox regression analysis multivariable logistic regression analysis respectively results low muscle radiation attenuation associated shorter survival comparison moderate high muscle radiation attenuation median survival months respectively patient subgroups high muscle radiation attenuation combined either low visceral adipose tissue age longer survival subgroups respectively muscle radiation attenuation inversely correlated adipose tissue high visceral adipose tissue associated increased surgical site infection rate conclusions low muscle radiation attenuation associated reduced survival high visceral adiposity associated increase surgical site infections strong correlation muscle radiation attenuation adipose tissue suggests presence ectopic fat muscle investigation image analysis implemented pre operative risk assessment assist treatment decision making
influence constant speed wind turbine electrical network torque impact lead various problems disturbances affect active power quality reactive power rms phase phase voltage paper propose original system control solve firstly problems due impact active power secondly control reactive power principle proposed wind energy system energy storage limit rapid variation active power give required reactive power compensation induction machine torque change directly coupled common link whole bidirectional converter control strategy use linear matrix inequalities regulate currents injected absorbed inverter strategy used control variable voltage simulation results using state feedback integral controller currents converter simple proportional controller cascaded axis current loop voltage source presented discussed
approaches salient object detection focused two dimensional images rare attention attached light field provide exclusive visual information salient object detection computer vision applications effective algorithm salient object detection proposed light field data first boundary connectivity calculated focus image background probability based boundary connectivity achieved computing distance second authors rank similarity focus image depth map via graph based manifold ranking carry two initial maps third weighted background probability two initial maps fused produce final results integrated cue authors also exploit integrate effectively visual features compare two fusion strategies linear fusion bayesian integration experiments show light field features helpful detection bayesian integration framework better choice linear fusion method meanwhile way combine multiple features crucial proposed algorithm handles challenging natural scenarios background similar background produces visual favourable results comparison eight state art methods
inductive power transfer systems facilitate power transfer two sides across air gap weak magnetic coupling however systems constitute high order resonant circuit difficult design control aiming control problems bidirectional system neural networks based proportional integral derivative pid control strategy proposed paper proposed neural pid method pid gains treated gaussian potential function networks weights adjusted using online learning algorithm manner neural pid controller flexibility capability conventional pid controller fixed gains convergence weights learning guaranteed using lyapunov method simulations used test effective performance proposed controller
current study compares diagnostic approaches section section iii included diagnostic statistical manual mental disorders dsm american psychiatric association diagnosis antisocial personality disorder aspd terms relations psychopathic traits externalizing behaviors section iii approach aspd explicitly trait based section approach also includes psychopathy created goal making diagnosis aspd congruent psychopathy community sample individuals currently receiving mental health treatment ratings dsm diagnostic approaches compared relation measures psychopathy indices dsm aspd approaches significantly related psychopathy scores although section iii approach accounted almost twice amount variance compared section approach relatively little predictive advantage however due traits manifested little evidence incremental validity relation existing psychopathy measures exception measure dominance overall dsm section iii diagnostic approach aspd convergent construct psychopathy aspd originally derived improvements however due primarily new trait based focus section iii aspd diagnosis rather assessment personality dysfunction inclusion additional psychopathy specific traits
prevalence information communication technologies electronic health services commonly used patients doctors healthcare professionals decrease healthcare costs provide efficient healthcare processes however using increases concerns regarding security privacy integrity healthcare data several solutions proposed address issues survey categorize evaluate state art electronic health system research based architecture services including access control emergency access sharing searching methods considering cryptographic approaches survey differs previous related surveys method based proposed services classified based methods compared solutions provide performance comparisons state commonly used methods category also identify relevant open problems provide future research directions elsevier rights reserved
studies demonstrated deficiency estradiol postmenopausal women influences immune system however studies reported alterations immunologic presentation menopause young females compared differences immune response young mice surgical medical aged mice common feature deficiency following con stimulation observed inverted ratios aged group apparent reduced production serum iga igm surgical group whereas changes immune parameters medical group moderate data suggested immunological response con stimulus differed among three groups deficiency partially responsible development immune deficiency aged mice
purpose following paper interview conducted industrial robot journal method combined technological business personal experience prominent robotic industry engineer turned successful leader regarding challenges bringing technological discoveries paper aims discuss issues design methodology approach responsible operational unit italian national research council institute electronics computer engineering early extreme environments founded new field interview shares year robotic along thoughts concerns robotics society findings received degree electronic engineering computer science control automation university worked automation division designer fault tolerant architectures fail safe control systems part development team new automation italian railway stations institute automation research worked real time computer graphics simulation control techniques marine data collection systems founded robotics department develop experimental robotics extreme environments approach utilized working prototypes virtual lab environment focused robot mission control real time human machine interfaces networked control system architectures robotics internet robotics founded association school robotics promote new science among young people society large means educational robotics continue research robotics also develop studies social ethical implications robotics originality value led first italian underwater robotics campaigns italian carried robot project first experiment internet robotics via satellite designed developed project first experiment worldwide internet robotics ever carried projects organized series live science sessions collaboration students teachers italian schools beginning new school robotics continued educate young people complex relationship robotics society led term propose concept since made worldwide efforts resources development new field general first international produced author scientific publications presented region innovation merits field science society title order merit italian republic one highest
although dyslipidemia increases risk ischemic stroke previous studies reported conflicting data regarding association lipid levels stroke severity outcome evaluate predictive value major lipids patients acute ischemic stroke prospectively studied consecutive patients admitted acute ischemic stroke males age years severity stroke assessed admission national institutes health stroke scale moderate severe stroke defined outcome assessed dependency rates discharge modified scale hospital mortality independent predictors moderate severe stroke age relative risk confidence interval atrial fibrillation heart rate log triglyceride levels high density lipoprotein cholesterol hdl levels major lipids predict dependency discharge independent predictors hospital mortality atrial fibrillation diastolic blood pressure log levels admission low density lipoprotein cholesterol levels associated stroke severity outcome lower hdl levels associated severe stroke lower levels also appear predict hospital mortality patients acute ischemic stroke
background gray substantial pain modulatory center previous voxel based morphometry study confirmed clusters increased volume region medication overuse headache aim study investigate altered volume using automated segment method measure true volume methods high resolution three dimensional weighted fast gradient recalled echo images obtained patients normal controls template created based gray template individual generated applying deformation field structural image segment template individual volume calculated results significant increased volume area receiver operating characteristic roc curve cut volume sensitivity specificity conclusion present study demonstrated volume gain confirmed patients automated individual volume measure considered simple effective imaging biomarker diagnosis
research suggests worry emotional processing biases attentional processes although evidence relationship executive functioning worry research area needed recent theory suggests one mechanism negative effects worry neural indicators attention working memory load however studies examined directly goal current study document influence visual verbal working memory load worry attention allocation processing emotional images image paradigm hypothesized working memory load decrease attention allocation processing emotional images tested among participants using modified paradigm results indicated visual verbal working memory tasks resulted reduction attention allocation processing images across stimulus types compared baseline task although individuals low worry data extend literature documenting decreased neural responding amplitude imagery visual verbal working memory load particularly among individuals low worry
splitting behavioural activity phase found nocturnal rodents nucleus coupling disorder similar phenomenon observed sleep phase diurnal human discussed suggesting called evening morning oscillators humans present case suffered bipolar disorder refractory various treatments various circadian rhythm sleep disorders delayed sleep phase sleep separation sleep resembling splitting rhythm found prolonged depressive episodes separation sleep evening morning components delayed sleep offset cycle developed lowering stopping dose however improved symptoms weeks accompanied improvement patients depressive state administration improve various circadian rhythm sleep disorders improve prevent manic depressive episodes via augmentation coupling network
combat training important now simulation real environment great significance two dimensional information unable meet demand present development virtual reality technology three dimensional simulation environment possible simulation environment addition terrain combat personnel combat tool simulation fire smoke effects also important since effects enhance immersion scene however special effects irregular objects make difficult simulate general geometry therefore simulation irregular objects always hot difficult research topic computer graphics particle system algorithm used simulating irregular objects design simulation explosion fire smoke based particle system applied scene besides scene simulation free display carried algorithm based gpu super video real time transformation method time human computer interaction function ultimately realized free display simulated realistic immersed environment
media violence continues concern parents policy makers researchers spite confidence expressed exposure television violence causes serious aggression violent crime hold serious flaws research methodology limits conclusions drawn widely cited studies paper examine series classic studies lessons learned conducting media violence research assess whether recent publications adhere standards conclude empirical reports serious flaws continue published compromising ability understand phenomenon elsevier ltd rights reserved
cdna encoding novel member family first time identified gut cdna library deduced amino acid sequence includes motifs involved binding hydrolysis glycine position terminal characteristic however amino acid terminal extension positions found family previously described including like proteins suggests new member family also supported phylogenetic analysis highly likely extended terminal novel addition occurring vertebrate split northern blotting analysis revealed transcript present tissues examined consistent involvement fundamental role like trafficking proteins
hybrid combined cooling heating power system driven biomass solar energy proposed enhance systems energy efficiency analyzed shown system primarily composed biomass sub system solar collector internal combustion engine dual source powered mixed effect absorption product gas produced drives internal combustion engine generate power waste heat generation utilized produce cooling heating collected heat solar collectors design conditions thermodynamic performances variable external conditions energy ratios investigated analyzed results indicate primary energy ratio exergy efficiency respectively carbon emission reduction ratio design condition analysis biomass solar energy shows biomass subsystem makes greater contribution total system primary energy ratio exergy efficiency contributions solar subsystem participation solar energy conducive system emission reduction elsevier ltd rights reserved
corpus model disease disrupted connectivity human brain pathological formation fibers results subtle severe cognitive deficits postnatal studies suggest characteristic abnormal pathways pathology compensatory structures emerge via neural plasticity challenge hypothesis assume globally different network organization structural already fetal brain twenty fetuses isolated corpus without associated malformations enrolled fiber connectivity among brain regions assessed using utero diffusion tensor imaging macroscopic scale compared gestational age matched normally developing fetuses multiple granularity network analysis gradually increasing connectivity strength tract diffusion anisotropy gestation dominant running running aberrant pathways short range connections regions fetuses associated abnormalities diffuse reduction cortical subcortical connectivity observed cases isolated global organization anatomical networks consisted less nodes brains dense connectivity thalamus cingulate cortex showed reduced network centrality fetal brains show globally altered connectivity network structure compared besides previously described revealed differently organized dominated increased connectivity findings provide evidence abnormal pathways already present early stages fetal brain development majority cerebral white matter elsevier inc rights reserved
proliferation large number images made necessary develop systems indexing organizing images easy access made content based image retrieval important area research computer vision paper proposes combination features analysis framework image retrieval work concept analysis exploited use wavelet transform paper combines local binary pattern moments multiple resolutions wavelet decomposition image first codes discrete wavelet transform coefficients images computed extract texture feature image moments codes computed extract shape feature texture feature constructing feature vectors feature vectors used search retrieve visually similar images large database proposed method tested five benchmark datasets namely performance proposed method measured terms precision recall results demonstrate proposed method outperforms state art methods terms precision recall elsevier inc rights reserved
abundant diverse set microbial communities covers surfaces collectively called microbiome functional impact various immune processes modulates many health related processes including autoimmunity active site host interplay intestinal mucosa growing evidence helped learn specific microbiota composition functionality determine intestinal barrier function furthermore modulate pro inflammatory anti inflammatory immune mechanisms remote organs addition microbial composition skin important functionality skin barrier autoimmune skin diseases review importance microbiome local systemic immune system disturbed microbiome host interaction affect development progression autoimmune diseases understanding associations help unravel new diagnostic therapeutic approaches diseases
synthetic steroid compound induces abortion recently found potentially pass human milk study aimed determine effects administration mice development reproduction progeny mice gavage fed daily either days days lactation controls received peanut oil growth mortality rate organ weight ratio sex hormone fertility progeny size sex ratio mortality rate second generation recorded significant differences observed average mortality rate female male pups organ coefficient uterus ovaries females adulthood comparison controls however organ coefficient testis day testosterone concentration day increased male pups moreover reproductive capacity pups unaffected exposure via mothers milk time birth pups size sex ratio mortality rate similar control pups conclusionthe study showed treating mice influenced organ coefficient testis day testosterone concentration male pups day however affect development fertility female male pups
parents increasingly turning online health discuss concerns childrens health seek advice health decisions study examines characteristics elaboration online discussions parents vaccine establishes types central peripheral message cues parents generated extent elaboration exchanges associated parents decisions childrens vaccination results indicated users employed central peripheral cues joint process generating information intended help parents gain knowledge make vaccination decisions issue relevant arguments important vaccination decision included vaccines necessity side effects efficacy peripheral cues including site generated sorting cues associated featuring greater elaboration new parents asking questions vaccine issues elaboration however elsevier ltd rights reserved
convection enhanced delivery promising technique generates pressure gradient tip infusion catheter deliver therapeutics directly interstitial spaces central nervous system addresses offers solutions many limitations conventional techniques allowing delivery past blood brain barrier targeted safe manner achieve therapeutic drug concentrations broadly applicable technique used deliver variety therapeutic compounds diversity diseases including malignant parkinsons disease alzheimers disease number technological advances made since development early clinical trials largely unsuccessful number parameters still need addressed successful clinical application review addresses physical principles behind limitations technique means overcome limitations clinical trials performed future developments
deficiencies cathode materials severely limit cycling performance discharge rates batteries key problem cathode materials combine multiple properties high lithium ion capacity electrical ionic conductivity porosity mechanical toughness materials revealed promising characteristics subset properties entire set often characteristics requires new methods materials engineering paper report high surface area composite reduced graphene oxide loaded nanoparticles made layer layer assembly high electrical conductivity composite combined high ionic conductivity toughness low impedance result materials properties reversible lithium storage capacity efficiency high respectively cycles moreover composites enabled high reversible charge discharge rates storage capacity exceeding known based several times retaining high content active cathode material study demonstrates assembled composites enable resolution difficult materials engineering tasks
useful challenging analyze select object features high resolution remote sensing imagery overwhelming majority existing feature selection methods always features long feature vector select features vector ignoring homogeneity heterogeneity underlying feature paper propose supervised feature selection method unlike existing methods requires prior knowledge number views independent classifier utilizing homogeneity heterogeneity data employs affinity propagation automatically decompose features multiple meaningful feature groups views without prior knowledge group view consists homogeneous features describing unique data characteristic different views represent heterogeneous data characteristics features evaluated selected based joint norm minimization loss function regularization term different popular norm joint norm sparsity instead interview sparsity consequently view represented representative features view information heterogeneous views kept remaining representative features experimental results four satellite images effectiveness comparison single view algorithms furthermore discussions conducted give insights homogeneity heterogeneity features
core hcs technically advanced products concrete industry widely used last years due versatility potential low cost using three dimensional fem finite element method elements study focuses stresses induced steel particular investigation crack formation takes place carried since important assure appropriate necessary margins concerning stresses fact cracks spread rapidly towards web leading lower part parametric study takes place capable evaluating influence tendon position web width stress consequently extensive literature review topic soft computing optimization hcs performed means genetic algorithms coupled fem models
two experiments investigated reactive top cognitive control detrimental influence semantically related words presented visually free recall experiment demonstrated increase focal task engagement promoted experimentally reducing perceptual visual target words eliminated disruption recall also attenuated erroneous recall recall instruction eliminates requirement output monitoring used experiment investigate whether increased task engagement distraction change output monitoring processes back end control affecting processing presentation front end control rates erroneous recall much greater experiment erroneous recall disruptive effect recall still attenuated reduced target word taken together results show task engagement dynamic strategic control modulated auditory distraction attenuating processing encoding thereby preventing coming mind test
study explored role progression possible signaling pathway involved mrna protein expression normal tissue benign fibrous dysplasia cell lines normal cell line different invasive evaluated immunohistochemistry icc real time reverse transcriptase polymerase chain reaction real time qrt pcr using vitro functional assays analyzed invasive proliferative abilities different cell lines differing invasive potential assess role invasion metastasis cells vectors small hairpin rna constructed used infect highly invasive low invasive cell lines effects knockdown upregulation biological behavior cells investigated functional vitro vivo assays results revealed expression upregulated positively correlated low differentiation lymph node metastasis poor prognosis also found expressed highly invasive cell lines highly invasive promote cell invasion metastasis inducing emt via akt mtor pathway collectively findings demonstrate promoter development progression suggest novel therapeutic target future studies
affective theory mind tom specific ability represent others emotional states feelings previous studies examined affective tom ability patients disease using reading mind eyes test results consistent showing difficulties inferring complex mental states photographs people even early stage however agreement whether cognitive impairments population contributed poor performance test aim present study assess whether affective tom ability impaired mild moderate stages whether association compromised tom ability presence cognitive impairment evaluated tom means global cognitive functioning means questionnaire patients healthy subjects groups matched age level education study showed ability judge persons mental states picture eyes impaired patients compared normal population indeed subjects gave correct responses whereas healthy control subjects percentage correct responses furthermore impairment correlated global cognitive functioning except visuospatial task results show represent valid instrument assess affective tom ability patients mild moderate stages disease independently cognitive status since known patients addition motor symptoms suffer cognitive deficits including memory executive impairments important instrument influenced cognitive abilities possible therefore use assess important aspects patients ability recognize others emotions feelings even patients suffer cognitive decline
graphics processing units gpus increasingly used high performance computing programming frameworks general purpose computing gpus cuda also driving trend recent proliferation mobile devices smartphones wearable computers devices increasingly incorporating computationally intensive applications involve form environmental recognition augmented reality voice recognition however devices low computational power satisfy demanding computing requirements cpu load devices reduced computation onto gpus cloud paper presents remote procedure call extension rich set runtime libraries device drivers achieving first class gpu resource management allows developers use cuda development work existing research uses based cuda application programming interfaces hence cuda require communication reduce communication overhead use based low level api cuda api reduced api require communication evaluation conducted linux gpus shows basic performance prototype implementation reliable comparison existing method evaluation using benchmark suite designed research heterogeneous parallel computing showed effective applications image processing data mining also improve power consumption approximately cpu processing performing matrix multiplication
site unique exceptional size quality conservation condition mosaic pavement covering urban installed protection rain sun interest characterise remains six probes relative humidity temperature sensors installed purpose monitoring allowed check relative humidity differences resulting groundwater level inner sensors reaching maximum temperatures higher ones consequence non covering site conditions site deemed detrimental conservation thus summer expanded clay geotextile installed corrective action outcomes study proven effectiveness solution control temperature relative humidity helping stable suitable preservation mosaic
hip fracture dementia increasing incidence global ageing population need development specific procedures targeting optimal treatment outcomes patients paper looks primarily factors limit access rehabilitation services growing body evidence suggests access timely inpatient rehabilitation increases functional outcomes patients dementia without information gathered searching electronic data bases scopus medline cinahl health source nursing academic addition cochrane library relevant articles using search terms dementia alzheimer hip fracture rehabilitation period abstracts scanned identify articles discussing eligibility access total nine papers identified directly addressed topic papers discussing success failure rehabilitation improved models care also reviewed barriers access discussed literature include information management management comorbidities attitudes resource availability quality evidence education identifying factors identify strategic points intervention across trajectory prevention treatment rehabilitation improve outcomes growing group vulnerable patients emerging best practice patients also discussed
ras signaling central many cellular processes proteins promote ras activation investigate role proteins cell biology crossed mice cre transgenic mice previously reported effect mutations cell signaling cell migration unexpectedly observed nodules joints greater mutant mice months age especially joints mice aged also displayed joint stiffness limb histological analysis indicated abnormal growth joints originated chondrocytes second harmonic generation imaging nodules revealed nodules rich collagen fibrous networks nodules formed mice also deficient indicating conventional cells undergo rearrangement cell antigen receptor required phenotype cre expression subset cells either immune lineage cells non conventional cells non immune lineage cells chondrocytes likely mediates dramatic phenotype observed study disruptions genes ras signaling pathway especially likely cause phenotype results also serve use cre transgenic mice specifically genes conventional cells
aims implement game features non game contexts goal increasing motivation individuals performing specific task set tasks tasks focus cognitive behavior change overcoming anxiety physical behavior change overcoming shoulder injury current methods primarily serve guidelines principles design applications moreover methods often complexity actually implementing game features consider effects game features individuals ability perform target task knowledge gap exists understanding complexity implementing game feature impact increasing individuals motivation performance particular task set tasks paper presents method evaluating complexity implementing game features physical effort required perform tasks application specific focus physically interactive applications designers gain fundamental understanding implementation specific game features contributes toward objective application case study presented focuses physically interactive applications virtual environment empirical results measuring effects game features participants performance presented provide evidence support metrics proposed study knowledge gained work inform designers manage resources efficiently predict possible design issues meeting objective application creating applications elsevier ltd rights reserved
ball beam basic reference point system high nonlinearity unstable system dynamics many simple present day control methods used balance ball beam system goal project model control ball beam system considering beam angle servo motor designing controllers control ball position approach used find ball position system based energy balance system based transfer function state space model open loop system closed loop system designed system designed using two degrees freedom nonlinear characteristic second order system regulated using pid controller controller controls ball position moving beam using motor disturbances parameters pid tuned using pid tuning algorithm order analyse pid learn effect simplifying expectation two control methods designed implemented using proportional derivative integral pid non model based control method proportional derivative proportional integral combination model based non model based control methods
reverse correlation techniques provide data driven approach model internal representations way used approach model social perception faces task participants repeatedly selected two face images created randomly generated noise face face looked trustworthy conditions dominant calculated classification images cis averaging selected images trait judgments independent participants objective metrics showed cis visualized intended traits furthermore tests pixel clusters showed diagnostic information mostly mouth eye hair regions current work shows provides excellent tool extract meaningful images map onto social perception
instead analog electronic circuits components digital controllers capable active multi resonant piezoelectric applied elastic integrated piezoelectric patches thanks recently introduced digital control techniques strategies possible now transfer functions hardly realized analog circuits example pole zero method developed design single multi resonant adjusting poles transfer function piezoelectric directly large simultaneous three frequency bands deep scale normalized frequency low achieved underlying physical mechanism attributable negative group velocity flexural wave within digital controllers readily adapted via wireless tuned easily unlike electric components analog circuits tuned one one manually theoretical results verified experimentally measured vibration transmission properties large low frequency ranges observed
child sexual abuse csa affects children annually united states primary obstacle success public health prevention strategy lack knowledge around community level risk factors csa evaluated community level characteristics children seeking care suspected csa greater area total incidence rate medical evaluations suspected csa children abstracted medical charts children sought medical evaluation suspected csa three main medical systems greater area evaluated community level variables american community survey codes children lived mean number cases per greater code range codes case three sites surveyed codes higher average rate houses never married females labor force high family poverty rate associated increased rate children seeking care suspected csa demonstrated codes level characteristics associated increased rate children seeking care suspected csa modelling process data implications community based strategies aimed improved surveillance prevention csa process identifying locally specific community level factors suggests target areas particular socioeconomic characteristics associated increased rate seeking csa evaluations
soil moisture salinity measurement essential factors crop irrigation increase yield depends water volume contents soil soil nutrients based conditions determined water demand best quality wireless sensor network wsn using lot chemical increases soil salinity reduces soil fertility soil salinity defines electrical conductivity soil precise agriculture systems integrated multiple sensors monitor control incident integrated wsn designed developed measure soil moisture salinity microcontroller soil sensors integrated across system system competent helpful automatic irrigation system soil salinity monitoring
potent cytokine stimulating therapy exogenous limited formation antibodies cross endogenous compounds antigenic similarity orally active small molecule binds transmembrane portion receptor mpl initial trials centered immune thrombocytopenia due increased destruction decreased production platelets day shown highly effective raising platelet count suboptimal response immunosuppression successful results led exploration disorders hepatitis viral infection raises platelet count sufficiently enough allow treatment ribavirin interferon mpl expressed hematopoietic cells use syndrome mds acute myeloid leukemia aml enhance proliferation clinical trials mds aml however shown thrombocytopenia without promoting disease progression severe anemia responding immunosuppression anti globulin single agent day results overall response rate high doses adverse effects including gastrointestinal hepatic become evident current studies examined first line use combination recent study used day resulted overall response rate newly diagnosed patients complete response rate clonal aberrations however found patients treated safety efficacy require evaluation particularly used less intensive immunosuppression
fatigue phenomenon occurs two parts contacted one parts subjected cyclic load decreases fatigue life materials drastically half even therefore investigation fatigue life materials important subject fatigue tests usually performed using universal hydraulic testing devices work rotating bending apparatus fatigue test introduced cyclic load provided adjustable load apparatus called machine rotating bending fatigue load measured load cell coefficient friction load measured strain using bridge configuration performance machine verified comparison fatigue lives number alloy samples rotating bending fatigue testing machine results shows close operations two testing main simplicity respect universal devices coefficient friction specimen evaluation test also capability used soft hard metals advanced high low temperature
background minorities historically clinical research trials despite comparatively poor health indicators recognizing dual inequalities increased disease burden decreased research participation national institute health act mandated inclusion reporting women minorities funded research progress made subsequent decades minorities research trials persists documented multiple disciplines however extent adequate representation reporting minority inclusion clinical trials migraine remains unknown objectives systematic review study review literature examining representation women minorities migraine clinical research trials methods first searched pubmed pertinent articles examining inclusion women minorities migraine clinical research trials second identified controlled trials migraine published since major neurology headache general medicine journals using terms migraine randomized controlled trial reviewed results manually excluded pilot studies fewer participants next determined frequently representation minorities women reported major trials factors correlated reporting whether women minority inclusion comprised ratios general population results identified relevant clinical trials met inclusion criteria trials reported gender frequency reported ethnicity race among studies women whites represented participants mean respectively studies conducted united states funded private company likely report race studies conducted exclusively outside public studies stratified efficacy safety ethnicity gender men non whites statistically conclusions recent headache studies comply include women minorities research trials particularly based industry funded studies whites compared general population population future studies increase minority participation investigate race based differences migraine expression treatment response medication toxicity
high performance control quantum dynamics key development quantum technologies quantum state engineering quantum theory practice quantum control enable robust cheaper technologies future industrial applications starting fundamental matter field interactions overview various approaches modelling quantum control systems control implemented either changing field material properties models built time frequency domain interconnected form quantum feedback networks review taken useful reference engineers understand quantum physics behind resolve control problems control engineering point view
consider strategic interactions monetary policies monetary union authority strategic advantage particular standard literature strategic interactions monetary solve three stage game two national authorities play simultaneously find always incentive leader authority play three stage game leaves authority worse demand choice leads less volatile union wide stance demand supply compared standard narrow coordination case volatility positively related demand elsevier rights reserved
paper utilize software engineering technique called statistical experimentally identify emergent behaviors system systems apply technique agent based model defense system component operational managerial independence geographic distribution develop simple game blue threats red repeat game large number results show strategy guarantees blue addition losing strategies ones finally four strategies appear half losses refer emergent since controlled either red blue side
paper presents investment feasibility analysis rainwater harvesting systems residential sector state southern brazil five selected analysis daily rainfall data average water consumption rainwater tank costs water pump costs water sewage electricity obtained five different values roof area number residents potable water demand rainwater demand analysed rainwater tank capacities estimated using computer programme investment feasibility analysis performed considering ideal lower tank capacity capacities smaller larger ideal capacities obtained according variation six months payback period observed ideal tank capacity conservative high rainwater demands cases investment feasibility analysis performed order obtain appropriate tank capacity main conclusion rainwater usage economically feasible cases higher rainwater demand higher feasibility
alleviate environmental pollution improve efficient use energy energy systems integration covering electric power systems heat systems natural gas systems become important trend energy utilization traditional power flow calculation method object power system prove difficult meeting requirements coupled energy flow analysis paper proposes generalized energy flow analysis method suitable containing electricity heat gas subsystems first models electricity heat natural gas networks established view complexity conventional method solve gas network including compressor improved practical equivalent method adopted based different control modes basis hybrid method combining newton algorithm executed compute nonlinear equations matrix reflecting coupling relationship multi energy derived considering grid connected mode island modes power system finally validity proposed method multi energy flow calculation analysis interacting characteristics verified using practical cases
background aims consumption beneficial effect cardiovascular health evidence prospective cohort studies still limited aimed examine prospective associations consumption risk stroke among men women large population based cohort methods total men women aged years free cardiovascular disease diabetes cancer baseline followed end respectively obtained data consumption participant using self food frequency questionnaire included food items cox proportional hazards regression models used estimate hazard ratios hrs stroke relation consumption results median follow years identified incident cases cerebral hemorrhagic adjustment age body mass index life styles dietary intakes risk factors consumption associated significant lower risk stroke women however association men significant addition association vary stroke subtypes either men women conclusions findings large japanese cohort supported significant inverse association consumption risk developing stroke women however residual confounding excluded alternative explanation findings elsevier rights reserved
rapid timely evaluation urban environmental change highly important understanding urban sustainability china however comprehensive understanding urban environmental change china based multi source remote sensing data remains inadequate current studies mainly focused single aspect urban environment using specific source remote sensing data study developed comprehensive evaluation index combining remote sensing data fine particulate matter concentration land surface temperature vegetation cover assess urban environmental change china national scale among urban across rapidly regions found trend environmental degradation urban areas china environmentally degraded moderately degraded urban areas accounted total urban area china particular expanded urban areas exhibited extensive environmental degradation total expanded urban areas exhibiting environmental degradation moderately environmental degradation increase concentration one main manifestations environmental degradation expanded urban areas suggest attention paid urban environmental issues future urban development china elsevier inc rights reserved
paper suggest using hybrid projection increase vertical geometric field view without large deformations preserve distance perception allow seeing surrounding ground conducted experiment houses evaluate perception distances spatial comprehension results show hybrid projection improves perception surrounding ground leads improvement spatial comprehension moreover preserves perception distances sizes providing performance similar perspective one task distance estimation
study explores relationship bar occupational personality questionnaire determine link self reported emotional intelligence personality traits data obtained managers working sectors included multi source measures emotional intelligence results indicated construct overlap correlations elements emotional intelligence stronger relationship measures emotional intelligence personality self report measure measure mood scale showed strongest link personality factors measures emotional intelligence include component thus provide useful indicator individuals ability manage feelings others
developing factory future objective graduate school excellence advanced manufacturing engineering achieve goal several research areas concerning factory future exist example strategies development information communication manufacturing material process engineering management global manufacturing networks one specific research project within area management global manufacturing networks global manufacturing networks software intensive service providers started december research project deals questions factory future able satisfy increasing need information communication technology ict future different ict services integrated existing global manufacturing network second step contribution hand considers motivation relevance research objective research project
using single crack solution regular plane harmonic function bending problem cylinder general cross section formulated terms two sets boundary singular integral equations solved using methods combination boundary element singular integral equation methods concept bending center used strength materials extended bending problem theoretical formulae calculate bending center stress intensity factors cylinder derived expressed solutions integral equations based results numerical examples given different configurations cylinder cross section crack parameters
domain specific self concepts good mathematics general school self concepts good school shown good predictors academic performance persistence even yet research predictors domain general cross self concepts good solving problems scarce basis generalized internal external frame reference model model study tested potential predictors domain general problem solving self concept structural equation models revealed line model self reported mathematics achievement complex problem solving exerted assimilation effects problem solving self concept expected relations self reported verbal achievement also found high association mathematics verbal problem solving self concepts simultaneous control school track general fluid ability assessed using fair subscales classification matrices decreased association complex problem solving problem solving self concept discuss possible impact domain general self concepts students performance elsevier inc rights reserved
energy harvesting now established field linear equivalent circuit models single multiple degree freedom systems routinely used assess energy harvesting efficiency various interface electronic circuits however field energy harvesting moves toward complex systems nonlinear energy harvesting energy harvesting modified equivalent circuits required effectively capture behavior devices article presents two general methods system level approach dependent source equivalent approach adequately model behavior advanced approaches also easily used model single multiple degree freedom linear equivalent circuits piezoelectric electromagnetic discussed four case studies presented illustrate application equivalent circuit approaches including following piezoelectric electromagnetic simplified aeroelastic piezoelectric rectifier circuit
human population century increasing incidence diseases obesity diabetes cancers food allergies many others recent studies shown oxidative stress caused reactive oxygen species free radicals underlie occurrence many diseases probiotics known beneficial effects health established dietary researchers trying find potential probiotic strains exhibit antioxidant properties along health benefits vitro vivo studies indicated probiotics exhibit antioxidant potential also many studies shown consumption probiotics dietary supplements reduce oxidative damage modify activity crucial enzymes human cells incorporation probiotics foods provide good strategy supply dietary antioxidants studies needed methods evaluate antioxidant properties probiotics recommended antioxidant potential paper presents latest news related probiotics potential
graft versus host disease serious complication associated allogeneic hematopoietic cell transplantation globulin widely used prior prevention though evidence efficacy remains unclear therefore identified nine randomized controlled trials rcts patients group non group conduct meta analysis actions relative risk risk ratio confidence interval calculated outcome rabbit reduced overall acute grade iii overall chronic extensive without increased risk relapse contrast reduce overall marginally reduced day transplant related mortality without compromising overall survival increased risk infections studies required evaluate optimal dosage formulation different conditioning regimens transplantation varied sources graft donor
alzheimers disease devastating progressive neurodegenerative disease characterized accumulation amyloid beta beta tau proteins brain deposition beta aggregates triggers synaptic dysfunction tau neurodegeneration lead cognitive disorders investigated neuroprotective effect beta mouse model single injections beta min mouse markedly induced memory synaptic deficits neuroinflammation neurodegeneration intraperitoneal injections dose day weeks starting beta injection significantly decreased beta induced accumulation beta expression tau protein serine treatment also markedly reversed beta induced synaptic dysfunction increasing levels proteins ultimately improved mouse memory observed water maze test significantly activated akt beta expression beta treated mice moreover prevented neuroinflammation suppressing various activated mediators also suppressed apoptotic neurodegeneration triggered beta injections mouse hippocampus immunohistochemical staining caspase revealed prevented neurodegeneration beta treated mice results suggest potent neuroprotective effect beta induced neurotoxicity results demonstrate flavonoids beneficial effective safe neuroprotective agent preventing neurological disorders
cohort study conducted examine association low carbohydrate diet score risk incident metabolic syndrome mets components years follow healthy adults within framework lipid glucose study calculated according intakes carbohydrate fatty acids refined grains vegetable protein fiber polyunsaturated fatty acids ratio glycemic load using food frequency questionnaire baseline final model adjustment age gender smoking status physical activity energy intake significant association score fasting plasma glucose beta triglycerides beta beta bmi beta mets risk scores beta conclusion associated decreased risk mets components adults
problem research strategy findings form based codes definition put emphasis built form characteristics traditional codes several adopting alternative euclidean traditional codes achieve certain objectives however extent codes differ integrating important planning design criteria examined use case study method evaluate extent adopted city compared previous code reflects leadership energy environmental design neighborhood development leed criteria evaluate contents codes point scale concordance leed criteria results indicate generally goes beyond reflecting leed criteria however important criteria mixed income diverse communities certified green building deserve attention practice planners seeking alternatives traditional code consider replacing also integrate planning principles leed incorporates strengthen proposed code benefit findings study determining extent certain built form characteristics leed criteria emphasized choosing appropriate alternative traditional codes
airborne wind turbines represent new fascinating concept future harnessing wind power concept consists realizing blades conventional wind turbine form power high speed perpendicular wind mounted turbine electrical generator power electronics converter electric power generated transmitted via medium voltage cable ground high flight speed power several times actual wind speed small area turbine required according law turbine low weight generation given electric power moreover high turbine rotational speed gear transmission necessary size generator also reduced landing power turbines act generators motors electric power supplied system like present work configuration power electronics converters implementation considered major aspect trade power weight ratio efficiency dependence cable weight cable losses voltage level power transmission investigated comparison made low voltage medium voltage versions generators furthermore interdependence weight efficiency bidirectional dual active bridge converter coupling output voltage generator cable discussed based concept offering best possible compromise weight efficiency power electronics system selected model control behavior derived power flow directions control structure proposed furthermore questions electromagnetic compatibility electrical safety treated conclusion essential results work summarized outlook future research given enable reader make simplified calculations comparison aerodynamic fundamentals systems summarized highly simplified form numerical values given system discussed work
objective frequent fungal infection world frequency constantly increasing aim study evaluate clinical features epidemiological trends years iran patients methods total patients clinically suspected cutaneous fungal infections examined skin scales nail sub debris examined direct microscopy culture species identified species level combination morphological physiological criteria results direct microscopy confirmed contamination rate cases cases culture positive distributed male cases female cases commonly infected age group years old prevalent type followed prevalent causative agent followed conclusion results showed considerable distribution species among population diverse age groups although fungi main agents prevalence showed meaningful increase years highlights importance rural mainly transmitted large animals noticeable information improves current knowledge establish effective prevention therapeutic strategies overcome disease elsevier masson sas rights reserved
instances widespread conflict mass socially prescribed gender roles often begin alongside rule law state institutions mass violence tears social fabric community accepted norms gendered behavior suspended recent conflicts including created temporary space inclusion women previously restricted public spheres capacities stands unique changes temporary following end state organs organizations community members close public spaces advocate return girls women pre gender structures practices paper analyze gender gender equality initiatives identifying three influential factors make recommendations replication success post conflict countries
objectives objective study report dose response phase clinical trials type inhibition patients lipid goals received per protocol dose increase every weeks methods patients receiving enrolled six phase randomized double blind double trials weeks versus placebo day subcutaneous dose increased week week ldl cholesterol ldl greater equal options studies patients without previous coronary heart disease risk factors ldl percentage reductions baseline treatment data compared week versus week results patients dose plus background achieved ldl less less week patients dose increased week patients achieved ldl goals week additional reduction ldl week week adverse event rates comparable patients versus without dose increase placebo controlled trials controlled trials conclusion patients achieved ldl goals plus receiving dose increase achieved ldl goals week additional reduction ldl copyright author published wolters kluwer health inc
paper addresses relevant issues concerning thermal hydraulics radiation damage neutron generation target built european source recently approved critical design review target unit consists set blocks placed inside wheel diameter order distribute heat generated incoming reach target radial direction material elements composed array pieces rest rotating steel support cassette distributed cross flow configuration thermal mechanical radiation effects resulting impact proton pulse analysed detail evaluation inventory products current design found conform specifications found robust enough deal several accident scenarios
article sub equation method presented finding exact solutions nonlinear fractional partial differential equations fractional complex transformation method used convert fractional order partial differential equation ordinary differential equation fractional derivatives described modified riemann sense apply method nonlinear time fractional differential equations aid symbolic computation variety exact solutions obtained copyright john wiley sons ltd
established approach developing new imaging agents treatments cancer begins recognition receptors overexpressed cancer cells ideally receptors also absent minimally expressed healthy tissue delta delta opioid receptors respectively match criteria expression cancer cells higher primary lung epithelial cells drug approved food drug administration fda treatment alcohol dependence prevention relapse opioid addiction since binds high affinity selected platform development novel ligands capable delivering cytotoxic payload non small cell lung cancer nsclc study outlines synthesis two ligands peptide peg synthesized amino conjugated dye vitro imaging binding affinity vivo imaging studies transfected cells used model system expression opioid receptor delta opioid receptor used competition respectively binding affinity studies mice bearing xenograft cells transfected delta delta opioid receptors animal model used pet imaging vivo studies although binding affinity studies encouraging data selected conjugates lacked sufficient specificity conjugates development information synthesis valuable laboratories working field published elsevier ltd
objective evaluate influence severity based birth weight maternal distress sensitivity infant development methods sixty eight mothers preterm classified extremely low birth weight low birth weight assessed months infant corrected age using scales infant development care index maternal sensitivity minute mother infant interaction parenting stress index short form psi maternal distress sixty six healthy full term infants mothers assessed procedure results groups showed similar levels care index psi nevertheless considering infant development outcome significant interaction birth weight maternal distress emerged higher hearing language mean association non mothers infants compared ones also interaction birth weight maternal sensitivity influenced infant development higher eye hand coordination hearing language locomotor significantly associated sensitive mothers infants conclusion severity interaction degree maternal distress sensitivity influenced level infant development practical implications taken together results suggest relevance considering severity maternal variables order implement appropriate interventions supporting parenting role pre term birth promoting adequate infant development elsevier ireland ltd rights reserved
myeloid plasma cell lymphoblastic neoplasms expected findings bone marrow much less commonly diagnosed primary processes lymph nodes objective review aid recognizing common hematopoietic neoplasms unusual setting initial presentation lymph nodes review historical background evolution testing strategies presented improve understanding need accurate diagnosis classification using current review based peer reviewed literature personal experience authors university medical center provides lymph node diagnostic consultation services oncology therapeutic hematopoietic cell transplant serving patients around globe although readily present bone marrow myeloid leukemia form myeloid sarcoma lymphoblastic lymphoma create diagnostic classification challenges present primary lymph node pathologies use diagnostic tools necessary ensure accurate reproducible diagnoses elsevier inc rights reserved
aim study assess environmental impact microbial fuel cells constructed aim life cycle assessment lca carried comparing three scenarios conventional system without mfc implementation system coupled gravel based anode mfc system coupled graphite based anode mfc systems served population equivalent designed meet effluent quality since implemented improve treatment efficiency coupled lower specific area requirement compared conventional system functional unit wastewater lca performed software using cml baseline method three scenarios considered showed similar environmental performance categories considered exception abiotic depletion potential impact category potential environmental impact system coupled gravel based anode mfc around times higher generated conventional system system coupled graphite based anode mfc attributed large amount less environmentally friendly materials metals graphite implementation especially case gravel based anode therefore system coupled graphite based anode mfc appeared environmentally friendly solution replace conventional reducing system footprint economic assessment showed system around times expensive conventional system elsevier rights reserved
objectiveto determine whether baseline nausea prior treatment migraine impact effectiveness potassium oral solution treating acute migraine great deal variability exists patients response migraine medications migraine associated nausea common debilitating reduce effectiveness oral medications cause patients delay taking oral medications known diminish therapeutic outcomes avoid taking altogether associated nausea also inhibits drug absorption resulting lower bioavailability studies shown nausea time drug administration predicts poorer response treatment interest understand effective migraine medications patients poor response two randomized double blind placebo controlled trials pooled post hoc subgroup analyses performed patients without nausea baseline patients without prior treatment efficacy assessments included percentage patients hours headache pain free primary endpoint without without without nausea without severe degree disability test stratified analysis center used evaluate treatment effect effects nausea prior use determined using logistic regression factors treatment group analysis center nausea prior use time dosing interaction treatment group nausea prior use time dosing resultsthe modified intent treat population consisted patients active drug placebo majority patients female time dosing patients reported nausea treated attack prior use recorded headache pain nausea patients active treatment group statistically significantly better response receiving placebo regardless whether nausea baseline logistic regression analysis treatment group predicted response parameters detectable group interaction baseline nausea treatment group predicted whether patients recorded severe disability hours patients active treatment group significantly likely headache pain free hours dosing whether previously treated naive patients experienced patients headache pain free interestingly placebo groups naive patients also likely logistic regression analysis treatment group predicted headache pain response use predicted lack response interaction two prior use predict outcome measures time dosing diminish effectiveness potassium oral solution rapid absorption profile enhance effectiveness patients nausea prior use predicted poorer headache response hours suggesting possibility subset patients likely refractory potassium oral solution effective naive patients reliable inference made study order treatment
therapeutic effect glial progenitor transplantation diseases currently attributed formation new myelin using magnetic resonance imaging mri show therapeutic outcome mice dependent extent cell migration presence mature compact myelin human mouse glial restricted progenitors transplanted mouse neonates followed one year mouse produced mature myelin detected multi parametric mri showed limited migration without extended animal lifespan sharp contrast human extensively significantly increased animal survival production mature myelin occur weeks post grafting conclude human extend survival transplanted mice prior production mature myelin mouse fail extend animal survival despite early presence mature myelin paradox suggests transplanted provide therapeutic benefits biological processes formation mature myelin capable foster rapid nerve conduction challenging current primary role function central nervous system elsevier inc rights reserved
monitoring cellular responses changes growth conditions perturbation targeted pathways integral investigation biological processes however manipulating cells environment live cell imaging experiments still represents major challenge coupling microscopy emerged powerful solution problem approach remains severely indeed rely polymer strongly variety molecules commonly used cell biology effect cellular environment capacity accurately modulate composition medium concentration specific compounds within implications reliability experiments overcome critical issue developed new free dedicated live cell imaging show interference small molecules also integrate module maintaining precise sample temperature ambient rapid temperature shifts importantly changes medium composition temperature efficiently achieved within chips recording cell behaviour microscopy compatible different model systems platforms provide versatile solution dynamic regulation cellular environment live cell imaging
measure nonlinear impedance electrode solution system novel method based free oscillation proposed high valued active inductance adjustable negative resistance constructed operational amplifier second order oscillation system measurement set connecting active inductance device test active inductance designed around meet measurement requirements low frequency negative resistor utilized adjust damping coefficient oscillation system order obtain enough number ring oscillation cycles parameter estimation free oscillation signal oscillation system obtained square wave voltage excitation processed hilbert transform instantaneous capacitance resistance calculated simultaneously implement nonlinear impedance measurement operational availability proposed method verified experimental results commercial available resistors capacitors impedance nonlinearity gold electrode immersed solutions different concentration tested compared obtained amplitude sinusoidal excitation methods results indicate proposed method successfully obtain impedance nonlinearity half square wave period
construction three dam china subsequent yangtze river induced major land use change three reservoir region increased inputs sediment nutrients diffuse sources water bodies several government programs implemented mitigate high sediment nutrient loads reservoir however institutional weaknesses focus economic development far widely effectiveness programs study eco hydrological model soil water assessment tool used assess effects changes fertilizer amounts conditions bench catchment three reservoir region diffuse matter releases study aims identifying efficient management measures priority results show reduction fertilizer amounts reduce phosphorus loads considerably without inhibiting crop productivity condition catchment strong impact soil erosion phosphorus releases agricultural areas hence economically feasible programmes focusing construction maintenance region implemented additionally corn fields efficient fertilization schemes agricultural land identified potential instruments reduce diffuse matter loads study carried three region findings also beneficial reduction water pollution areas strong agricultural use
paper proposes framework development sensor node software various operating systems sensor network environment proposed development framework consists attributes code templates development support tool sensor node software developed based framework four steps sensor network modeling design design code generation accordingly paper presents methods attributes design code templates design mapping source code generation proposed technique sensor network software increased since models attributes code templates various operating systems framework productivity software development increased software design easily performed using attributes software codes nodes sensor network generated model also sensor network software increased since new functions existing operating systems new operating systems added framework sensor network software applying added functions operating systems
rates children rising united states countries validated functional disorder adults requiring diagnosis contrast studies children require upper abdominal pain absent ultrasound abnormal ejection fraction stimulated diagnosis aimed systematically review existing literature children determine validity reliability diagnostic criteria assess outcomes following performed systematic review following prisma checklist searched databases including pubmed scopus embase medline web science cochrane library articles screened additional studies search terms yielded articles included three articles manually added searched references reviewed peer reviewed publications retrospective chart reviews heterogeneity diagnostic criteria values outcomes laparoscopic varied success consensus concerning factors influencing outcomes observational retrospective study designs comprised review limited interpretation safety efficacy investigations treatment children symptoms overlapped functional need consensus symptoms defining validation testing required diagnosis randomized controlled trials comparing medical versus surgical management children upper abdominal pain
pregnancy risk factors cerebral venous sinus thrombosis however studies describing diagnosis management population limited objective study published case reports series regarding diagnosis management pregnancy searches pubmed cochrane library performed using search terms pregnancy sinus occlusion sinus thrombosis studies included pooled analysis included individual patient symptoms management approach follow condition multivariate regression utilized assess effect non modifiable factors excellent outcome sixty six patients included mean duration symptom onset diagnosis days involvement superior sagittal sinus seen cases transverse deep venous system cases management approaches included anticoagulation patients intra arterial alone fifty nine percent patients follow presentation headache alone associated excellent outcome multivariate analysis predicted excellent outcome compared alone patients undergoing demonstrated trend toward better outcome elsevier ltd rights reserved
background almost six decades different surgical techniques developed treat patients morbid obesity various surgical techniques generally divided respect effect restrictive humoral combination surgically modified human metabolism metabolic diseases particularly diabetes even non obese patients understanding metabolic effects changed traditional paradigm bariatric surgery simple weight loss procedure metabolic surgery affecting whole body metabolism proper surgical technique individual patient important factor influencing long term results comorbidities quality life recommendations patient selection surgical methods pre postoperative patient management metabolic surgery principles current concepts presented
paper propose optimization framework interior fabricated shapes interior important technique widely used industrial designs achieve functional purposes interior shapes objects formulate functional purpose objective function optimization problem whose solution indicates optimal interior shape contrast previous volumetric methods directly represent boundary interior shape triangular mesh use relate time derivative object function virtual velocity field iteratively evolve interior shape guided velocity field surface tracking iteration compute velocity field guaranteeing decrease objective function solving linear programming problem demonstrate general framework novel application designing objects floating fluid two previously investigated applications print various optimized objects verify effectiveness
hybrid power system uses many wind turbine generators solar isolated small areas however output power renewable sources constant quickly serious effect system frequency continuity demand supply order solve problem paper presents new frequency control scheme hybrid power system ensure supplying high quality power isolated areas proposed power system consists fuel cell battery energy storage system diesel engine generator furthermore plug hybrid electric vehicles evs implemented customer side full order observer utilized estimate supply error estimated supply error considered frequency domain high frequency component reduced low frequency component supply error mitigated using two controllers implemented proposed system control system frequency reduce supply error epsilon multi objective genetic algorithm epsilon applied optimize controllers parameters performance proposed control scheme compared recent established techniques pid controller tuned quasi oppositional search algorithm effectiveness robustness hybrid power system investigated various operating conditions
obesity headache two highly prevalent diseases adults children associated strong personal social impact many studies suggest obesity comorbid headache general migraine particular obesity seems risk factor migraine progression migraine frequency adults children research shows multiple areas overlap migraine pathophysiology central peripheral pathways regulating feeding inflammatory mediators gene related protein neurotransmitters serotonin peptides adiponectin adp leptin explain common pathogenesis paper discussed association obesity migraine analysis recent studies children reviewed data literature order assess association obesity headache clarify possible common pathogenic mechanisms
release precipitation global precipitation centre based rain allows quantification mean land surface precipitation part global water cycle release bulk correction applied compensate gauge paper derive improved correction approach based weather reports period compared results show approach tends correction central eastern europe especially northern winter regions throughout year applying mean weather dependent correction precipitation gives value precipitation per year excluding global land surface warming nearly relative pre industrial temperatures expected accompanied increase global land ocean precipitation however comparison year reference periods reveals significant trend land surface precipitation caused large variability precipitation varying data coverage time issues related sampling rain gauge networks continues improve quality database generate precipitation analyses homogeneous data coverage time another way reduce sampling issues combination rain gauge based analyses remote sensing satellite radar datasets
study examined whether grouping people meaningful social scenes two people impacts basic perceptual analysis individual explore issue measured neural activity using functional magnetic resonance imaging fmri participants sex categorized congruent incongruent person dyads two people interacting plausible manner incongruent person dyads elicited enhanced neural processing several high level visual areas dedicated face body encoding posterior middle temporal gyrus compared congruent person dyads incongruent congruent person scenes also successfully differentiated linear multivariate pattern classifier right body area left body area finally increases person scenes judged independent observers accompanied enhanced activity bilateral posterior insula findings demonstrate processing person scenes goes beyond mere stimulus bound encoding agents suggesting changes relations agents affect representation category selective regions visual cortex beyond elsevier ltd rights reserved
construction sector great potential reduce total energy consumption techniques applied sustainable projects world policy makers already realized potential begun setting governmental goals since new regulations achieving sustainability recently set change conventionally practiced administrative patterns construction sector number claims related sustainability features construction projects growing ever since construction contracts playing critical role preventing types legal administrative risks lead claims result changes caused need alterations practices since alterations new field one however find limited number researches studying analyzing possible regulatory risks associated green projects consequent probable legal claims result present research intends fill gap literature identifying risk factors lead claims sustainable construction also assessing factor basis opinions industry professionals analyzing factors relative importance index method findings study aim increase level awareness construction professionals probable risks revealing possible legal risks sustainable projects study also assist various parties contract particular conditions accordingly order prevent probable future claims elsevier ltd rights reserved
objective easy use easy assessment methods measuring shared understanding teams hard find paper describes experiment measure called shared priorities based ranking self generated strategic items assessed trained teams compared non trained teams dynamic problem solving task maturity participating teams also assessed using content analysis measure shared priorities measure used alongside documented measures team awareness based self rating results show shared priorities measure correlates task performance also distinguish trained teams however shared priorities measure correlate team measures cars awareness rating scale distributed assessment team mutual awareness suggesting captures different quality teamwork self rating measures shared priorities measure found easily administered
although complex crucial maintaining stem cells molecular basis underlying regulation lineage specific differentiation remains unknown revealed highly conserved important maintaining stability protein salt bridge asp contributes interaction post translational modifications somatic mutation detected bladder cancer patients impaired asp salt bridge interaction produced recombinant protein overexpressed pluripotent stem cells reduced binding significantly regulated genes controlled complex specifically regulated genes family genes promote epithelial mesenchymal transition thus conclude modulated interaction controls epithelial mesenchymal transition specification induced specific differentiation signals
physiological conditions endothelium generates signals nitric oxide endothelium dependent regulation vascular tone relative importance two signals depends diameter blood vessels diameter arteries decreases contribution regulation vascular tone increases mechanism involved varies species blood vessel types nevertheless activation endothelial intermediate small conductance calcium activated potassium channels respectively characteristic pathway mediated reduced endothelial dysfunction develops ageing hypertension less pronounced female age matched male menopause impaired mediated relaxation related reduced involvement response becomes dependent latter depends activation adenosine activated protein kinase silent information regulator proteins associated process cellular senescence vascular signalling response female hormone understanding role like responses help identifying effective pharmacological strategies prevent development vascular complications different
paper presents pulse compression radar analog signal processing integrated silicon process low cost power dissipation analog signal processing circuitry exhibits properties codes maximizes sensitivity resolution pulse radar system speed resolution requirements analog digital converter adc via analog circuitry includes two stage variable gain amplifier high dynamic range integrator circuit comparator offset calibration circuits differential bit designed adaptively track path loss rapid change gain offset calibration dynamic range requirements measured performance shows gain variation group delay imbalance states high speed pulse compression correlation performed analog current domain speed requirement adc reduced factor equal duty cycle lowering adc power consumption chip fabricated process wire bonded printed circuit board tested field programmable gate array board evaluate system performance different radar codes
now known lymphocytes play critical role development several cardiovascular diseases example studies group shown hypertension associated excessive accumulation cells vessels kidney development experimental hypertension tissues cells produce several cytokines affect vascular renal function leading sodium water retention fully understand cells cause cardiovascular renal diseases important able identify quantify specific cell subsets present tissues cell subsets defined combination surface markers cytokines transcription factors express complexity cell population makes flow cytometry intracellular staining technique dissect phenotypes lymphocytes present tissues provide detailed protocol identify surface intracellular markers cytokines transcription factors cells isolated murine kidney aorta aortic lymph nodes model angiotensin induced hypertension following steps described detail isolation tissues generation single cell suspensions vivo stimulation fixation staining addition several fundamental principles flow cytometric analyses including choosing proper controls appropriate gating strategies discussed
purpose purpose paper identify risks challenges related change building construction projects european union zero energy building year another goal create solutions risks challenges design methodology approach workshop method chosen gather date information construction cluster finland findings workshop main concern level knowledge know parties working construction projects answer challenge serious substantial education organisations competence requirements designers much possible next years offered also seen vital project tight schedules project delivery systems also seen risk projects however modern project delivery systems seen problematic practice even functional theory originality value results workshop valuable parties working building construction projects finland whole area
computer aided process planning important bridge computer aided design cad computer aided manufacturing cam computer integrated manufacturing environment operation sequence generation one difficult tasks aim operation sequencing determine best order machining operations minimal manufacturing cost satisfying constraints paper presents proposed method optimizing operation sequence using modified clustering algorithm key concept method constraints firstly checked selecting possible next operations last operation sequence traveling costs compared choose optimal feasible operation minimum traveling cost sequence operation sequences calculated total traveling cost obtaining optimal sequence result removing sequences beginning procedure selecting optimal operation sequence step time significantly reduced capability performance proposed method demonstrated three specific case studies comparisons show proposed method solve problem much lesser computational time generating alternate optimal feasible sequences previous algorithms
background development disturbances skin type diabetes characterised assessed skin longitudinally onset diabetes years duration investigate disturbances start material methods seventeen adult patients type diabetes participated skin microvascular function digit left hand investigated laser doppler arbitrary units carried rest following one min arterial occlusion time peak percentage increase post reactive determined assessed photographs recordings results skin microvascular function remained normal first five years compared baseline non diabetic reference group time peak prolonged years diabetes lower reference group years lower baseline years diabetes one patient developed first signs found years diabetes conclusions functional disturbances total skin observed seven years patients type diabetes preceded diabetic complications
specific anti epidermal growth factor receptor egfr monoclonal antibody used cancer treatment although development resistance recognized underlying mechanisms remain unclear present study characterized resistant oral squamous cell carcinoma cell lines human cell lines sas used present study effects inhibitors including growth cells assessed mtt assays southern blotting immunofluorescence analysis performed examine protein expression localization sphere formation used characterize stem cell like properties floating aggregation culture used independent growth inhibited proliferation cells sas cells proliferation three cell lines inhibited egfr inhibitor egfr inhibitor strongly inhibited proliferation sas cells moderately egfr proteins localized cell surface phosphorylated three cell lines sas cells serum free monolayer culture formed spheres single cells floating culture serum free culture conditions form spheres growth sas spheres required serum inhibited thus resistant sas cells engaged egfr independent growth also exhibited stem cell like properties however growth egfr dependent aggregation culture sas cell aggregates became sensitive suggests sensitivity cell type dependent also affected growth microenvironment
improve electromagnetic effectiveness light weight carbon foam magnetic nanoparticles embedded processing developed coal pitch mixture coal pitch nickel nanoparticles template technique heat treated degrees ascertain effect nanoparticles embedded characterized scanning electron microscopy ray diffraction raman spectroscopy vector network analyzer vibration sample observed nanoparticles embedded carbon material play important role improving structure electrical conductivity catalytic structural investigation suggests nanoparticles embedded carbon material bulk surface demonstrates excellent response frequency range ghz total effectiveness dominated absorption losses total governed absorption losses increase due increase dielectric magnetic losses ferromagnetic nanoparticles high surface area thus light weight embedded small amount magnetic nanoparticles useful material stealth technology
paper discusses measurement frequency response functions various converters frequency domain identification procedure applied measured frequency responses identified transfer functions primarily used developing behavioral models converters distributed power systems based upon converters cascade parallel several configurations system level analysis complete system becomes complex identified transfer functions high order therefore certain technique needs applied order reduction identified transfer functions process order reduction ensured system dynamics full order system technique used based singular values system systematic procedure given retain maximum energy states reduced order model dynamic analysis performed behavioral models based full reduced order frequency responses close agreement results effectiveness model order reduction stability key design objective system designer therefore measured frequency responses interface source load also used predict stability system
movement difficulty overcoming wanted call death drive term remains doubly problematic first indispensable antagonist binding reduced particular drive secondly plays vital role idea death drive addition drawback thrust aggressive component now precisely lack leads constantly observed register aggression much essential role process illustrated several key operations subjective development activity discharge work opposed fixation parental function finally treatment work analysis means dynamic component death seek explain concept better
paper describes reinforcing effects multiple layers combination rubber soil mixture layers sand compares behaviour reinforcement alone using plate loading diameter plate load tests performed outdoor test natural ground measuring plan depth used tests non pocket size height fabricated continuous polypropylene nonwoven geotextile optimum embedded depth first layer vertical spacing layers found approximately times diameter optimum percentage rubber replacement found around weight soil mixture bearing capacity increase settlement reduction highest multiple layers rubber reinforcement used results show efficiency decreased number reinforcement layers increased particularly low settlement ratios higher bearing capacity lower settlement achieved replacing layers layers rubber soil mixture ratio settlement plate diameter values bearing pressure ratio respectively unreinforced installation installation three layers installation three layers rubber soil layers inclusion layers reduces vertical stress transferred foundation bed load wider area example pressure kpa applied soil surface transferred pressure depth reinforced bed one two three layers respectively compared stress unreinforced bed furthermore use combination rubber soil mixture layers effective use layers reducing stress transferred example soil surface carries stress kpa vertical stress less two layers combined two rubber soil mixture layers two layers
microbial fuel cells shown useful changing iii related surface active bacteria occurrence intracellular reduction still unclear based four isolated reduced assigned based iii fluorescent probe used first time sense intracellular iii ions inevitably transiently formed reduction reduced mfc resulting intracellular accumulation total composite iii ions forms complex open circuit controls intracellular total ranged iii ions forms study illustrates cathode directed intracellular reduction gives alternative approach developing imaging functionally sensing iii ions mfc elsevier rights reserved
aim present paper study virtual steady state vibrations resonance conditions rotor six degrees freedom linear homogeneous viscous field unstable frequencies zones determined limited power electric motor linear characteristic one time constant method applied single basic resonance small difference natural driving frequencies influence motors time constant analyzed value unstable zones quasi steady state increasing decreasing frequencies jump phenomenon special condition increasing driving frequency growing rate seen right resonance due transfer small angular coordinates main rotation experimental result applied
diseases neurodegenerative pathologies characterized accumulation protease resistant form cellular protein named protein brain accumulation endoplasmic reticulum result dysregulated calcium homeostasis subsequent initiation protein response leading neuronal dysfunction apoptosis molecular mechanisms transition adaptation stress stress induced apoptosis still unclear mitogen activated protein kinases serine threonine protein kinases rule signaling many extracellular stimuli plasma membrane nucleus however identification numerous points cross talk mapk signaling pathways contribute understanding consequences stress diseases indeed mapk signaling network known regulate cell cycle progression cell survival death responses following variety stresses including protein response stress article review signaling diseases discuss mapk signaling pathways also describe role played mapk signaling cascades alzheimers parkinsons disease also overview mechanisms cell death role mapk signaling disease progression highlight potential avenues therapeutic intervention
ablation effectively esophageal high grade dysplasia efficacy treating anal high grade squamous lesions prospective study assessed safety efficacy applying anal twenty one hiv negative participants anal circumference treated anal participants assessed every months months high resolution recurrence treatment zone treated focal twenty one participants mean lesions range enrolled completed trial six participants recurrent within treated circumference within year four participants persistence index lesion months one index persisted months participants two treatments curve predicted free survival within treatment zone year comparing first last participants predicted year free respectively suggesting learning curve treating physician multivariable analysis showed decreased recurrence last participants increasing bmi increased recurrence participants device procedure related serious adverse events anal heavy bleeding yielded high rate anal eradication hiv negative patients year minimal adverse events lesion persistence probably related incomplete initial ablation
previous work demonstrated characteristic changes occur anterior wrist medial electric deaths hand foot electric circuit pathway electric shock rat model however whether phenomenon occurs humans unknown aim present retrospective study ascertain whether anterior wrist medial also selected promising significant sites electric death hand foot circuit pathway nineteen human cases autopsy one clinical sustained severe electric shock hand foot circuit pathway analyzed additional ten autopsy patients died traffic accidents sudden cardiac attacks used control group histopathological changes soft tissues anterior wrist medial autopsy patients electric current pathway observed results showed nuclear anterior wrist medial soft tissues electric death extremely noticeable compared controls severe electrical injury occurred anterior wrist findings suggest soft tissues anterior wrist medial parts limbs used complementary sites tissue selection considered necessary locations examinations assess electric death identification
introduction evaluated performance muscle perfusion scan assess muscle perfusion reserve prediction incident diabetic foot methods recruited diabetic patients without history five mci injected repetitive dorsal right foot posterior counts region interests roi right left collected calculated percentage counts right roi counts left roi counts left roi six patients complete study due technical errors patients followed possible occurrence least months results range days follow period patients developed lower patients developed foot comparison without foot cutoff first values discriminated patients without future accuracy value conclusion useful detect patients diabetes risk future
major platelet receptors appear complex fact logical reasons developed way short review describe origins developed information became available relationships established receptors types cells difficulties also alternative systems various described listed remain areas immunology transfusion accepted leaves something desired unlikely major changes occur
finite element simulation mixed convection within porous square model carried present work penalty optimization based finite element method used solve partial differential equations heat fluid flow concept employed visualize heat flow within closed based motion horizontal wall cases vertical wall cases involving hot bottom wall cold side walls top wall various fluids number reynolds number number higher permeability leads enhanced convection cases although direction motion wall significantly influences fluid flow field within due decoupling fluid thermal fields low conductive heat transfer occurs seen end end also found overall heat transfer rates bottom wall identical cases cases irrespective convection dominant heat transfer occurs cases strong convective circulation cells observed cases shaped also observed along cases multiple convective cells observed cases observed strengths fluid heat circulation cells less compared cases due weak force high order achieve high heat transfer rate bottom wall mixed convection involving various moving walls case case vertically moving wall preferred high case case vertically moving wall preferred based maximum heat transfer rate bottom wall published elsevier masson sas
acquiring high quality imagery since launch tri stereo three view three line array imagery become one top choices extracting dsm digital surface model products china past years tri stereo sensors offer users ability capture imagery large regions including entire territory country china resulting large volume tri stereo scenes require timely near real time processing something currently possible using traditional photogrammetry paper presents high performance computing solution efficiently automatically extract dsm products tri stereo imagery high performance computing solution leverages certain parallel computing technologies accelerate computation within individual scene distributed computing technology increase overall data throughput robust efficient manner taking advantage inherent efficiencies within high performance computing environment dsm extraction process exploit combinations offered set tri stereo images forward forward dsm results merged potential combinations minimize incorrect matches also offer ability remove potential exist single stereo pair resulting improved accuracy quality versus merged accelerated performance inherent within individual steps dsm extraction workflow including collection ground control points tie points image bundle adjustment creation images computing elevations preliminary experiments large area china proven high performance computing system generate high quality accurate dsm products rapid manner
tumor microenvironment liver plays important role primary metastatic liver tumor formation tumor growth promotion cellular non cellular components significantly influence tumor development growth metastatic spread anti tumor immunity response tumor therapy cellular components liver consist infiltrating immune cells also liver resident cells liver sinusoidal endothelial cells hepatic cells promote tumor growth negatively regulating tumor associated immune responses review characterize cells pro anti tumor function primary metastatic liver tumors furthermore summarize mechanisms permit growth hepatic tumors despite occurrence spontaneous anti tumor immune responses novel therapeutic approaches targeting tumor specific immune responses improve survival liver cancer patients published elsevier inc
large scale science features complex structured workflows comprised computing modules intricate inter module dependencies mapping workflows heterogeneous network environments optimizing end end performance crucial success scientific collaborations require fast system response smooth data flow construct analytical cost models formulate workflow mapping optimization problems minimum end end delay maximum frame rate difficulty problems essentially arises topological matching nature spatial domain resource sharing temporal dimension processing applications develop workflow mapping algorithm based recursive critical path optimization procedure minimize latency streaming applications conduct rigorous workflow stability analysis develop layer oriented dynamic programming solution based topological sorting identify minimize global bottleneck time accuracy proposed exact delay calculation algorithm verified comparison approximate solution dynamic distributed system simulation program real network deployment performance superiority proposed mapping approaches illustrated extensive simulation based comparisons existing algorithms verified large scale experiments real life scientific workflows effective system implementation deployment real networks
paper presents new three inputs one output current mode universal filter employing one modified current differencing transconductance amplifier two grounded capacitors filter realize low pass high pass band stop pass responses appropriately connecting input terminals realize filtering functions without component matching conditions inverting type input signal requirements natural frequency electronically controlled bias currents active passive sensitivity filter low pspice simulation results performed confirm presented theory
many studies focused supporting studies researchers helped multiple players perform without using system artificial virtual several approaches taken field conduct players using conductor made computer graphics others conduct changing moving figures however studies demonstrated conduct specific instructions player propose group personalized virtual group players date studies virtual addressed single conductor however required dynamics different based players role part personalized conduct desirable developed prototype includes group personalized virtual found tendency better players
throughout history seen concept modified due changes different societies mens patterns behavior toward pregnancy parenting evolved affective forms merely related material aforementioned brought case loss child perinatal period males experience significant impact psychological psychosocial aspects affects quality life purpose paper briefly present information topic clinical experience psychological management perinatal loss men
practice rainwater harvesting rwh spreading rapidly urban areas article studies impact possible generalization practice proposing new method quantify potential potable water savings using rainwater harvesting urban level proposed method based adaptation already validated model assessing single buildings use urban databases two concepts introduced building type allows gathering buildings sharing common features equivalent building used assess set buildings building type single building case located paris method shows using rainwater harvesting represents total potable water consumption residential buildings account potential method applied level acceptable reliability regard means implemented terms collecting information
soluble microbial products act precursor besides natural organic matter source water polluted biologically treated wastewater effluent main component influential factors precursor investigated study model feed substrates biologically incubated simulate biological treatment wastewater produced according standard procedure study formation potential feed chemical type crucial factor affecting production following formation four kinds model feed substrates initial organic carbon concentration produced wide range also different formation properties different organic substrates facilitate growth different microbial species produce varied levels chemical structure subsequently different formation characters environmental factors anaerobic condition showed significant effect producing extremely high probably due production volatile fatty acids different incubation conditions bring different levels also different formation
software enables genotyping microsatellite loci using next generation sequencing data amplified large sequenced pooled reads sequence files automatically scores microsatellite genotypes uses fuzzy matches allow sequencing errors applies decision rules account amplification including amplification products replication pcr amplification differential amplification alleles important feature generation length frequency distributions amplification products locus individual analogous traditionally used score microsatellite genotypes enable rapid evaluation editing automatically scored genotypes written runs windows mac linux systems includes simple graphical user interface demonstrate using data genotype per run illumina evaluated accuracy automatically called genotypes using two methods based repeat genotyping data obtained estimates mean genotyping error rates estimates three loci accounted disproportionate fraction genotyping errors conversely loci scored detected error error rate results show appropriate selection loci automated genotyping
behaviour central many fields definitions specifying basic assumptions considered behaviour largely lacking research explores challenges defining behaviour highlighting biases frequent lack differentiation physiological phenomena meet challenges article definition behaviour applicable across disciplines allows behaviours differentiated kinds phenomena definition used explore phenomena language whether conditions language considered behaviour concept two different levels meaning human language introduced highlighting language inherently relies behaviours content said constitute interpersonal behaviour particular conditions analyses reveal ways language extends humans behavioural possibilities far beyond enabled non language behaviours novel concepts complement expand existing theories behaviour language contribute novel piece theoretical explanation regarding crucial role language played human evolution
paper proposes conjugate gradient back propagation based artificial neural network real time power quality assessment novel real time voltage detection classification scheme using artificial neural network presented ann trained matlab using voltage sampled signal data corresponding parameters neural network utilized implement labview real time detection classification resilient back propagation conjugate back propagation algorithm performance evaluated matlab find best neural network real time application among three back propagation algorithms conjugate gradient algorithm better performance real time power quality monitoring mathematical model conjugate gradient back propagation neural network implemented labview real time voltage signals different time duration magnitude intensity acquired hardware experimental setup hardware setup mainly consists single phase voltage source microcontroller solid state voltage signals sensed using high precision voltage sensor data acquisition system used acquire signal voltage sensor output data acquisition system given personal computer labview proposed monitoring system also detects odd even harmonic components voltage signal acquired using fft real time hardware results obtained using proposed power quality monitoring system detection voltage harmonics claims suitability robustness adaptability monitor power quality issues elsevier ltd rights reserved
many human syndromes involve loss due loss gain dna methylation occur therefore difficult detect conventional methods human region crucial control fetal growth locus associated two clinical disorders opposite phenotypes syndrome characterized fetal high risk tumors silver syndrome characterized intrauterine postnatal growth restriction recently using southern blotting diagnosis describe powerful quantitative technique allele specific methylated multiplex real time quantitative pcr pcr diagnosis two complex disorders first checked specificity probes primers used pcr carried statistical validation method retrospective prospective populations patients analysis demonstrated pcr sensitive southern blotting detecting low degree moreover pcr rapid reliable simple safe cost effective method wiley liss inc
automatic generation procedures combinatorial optimization problems emerging new alternative address problems class one problems still offering great computational difficulty traveling problem simple presentation great difficulty exists solving numerically results obtained far problem based hybridization known heuristics however still need experimental breakthrough study possible combinations heuristics represents huge search space paper explore space using evolutionary computing automatically design new algorithms problem carried computational experiment produce algorithms competitive existing heuristics also contain several novel structures directly influence performance
european project aims deliver innovative bio processes eliminate emerging classic organic pollutants bio processes based concept immobilization microorganisms enzymes encompass enzyme technology remediation process immobilization based technologies applied engineered situ natural systems situ groundwater wastewater soil selection application modern physico chemical biological monitoring tools combined rational understanding engineering enzymology microbial physiology pertinent approach open black box selected technologies reliable process monitoring constitutes basis developing refining kinetics models turn improve performances achieved technologies key strength possibility direct implementation technologies five european reference sites confronted pollutants two technologies tested site starting first year deliver set tools techniques processes enhance ability communities respond challenges organic pollutants also frameworks structuring making evidence based decisions sustainable appropriate measures consortium includes fifteen partners eight european countries eight research education institutions five covering whole chain approaches production monitoring engineering one large end user operating wastewater treatment plants one environmental agency work together support board mainly consisting environmental decision makers
linguistic cognitive abilities manifest huge heterogeneity children autism spectrum disorder asd children present language cognitive abilities others show variable patterns development using spontaneous language samples investigate presence extent language impairment heterogeneous sample children asd findings sample suggest children asd categorized three meaningful subgroups normal language marked difficulty production relatively intact vocabulary globally low language abilities findings support use sensitive assessment measures evaluate language autism utility within disorder comparisons order comprehensively define various cognitive linguistic phenotypes heterogeneous disorder
wound plays role preventing infection accelerating healing wounds especially chronic non healing wounds recently fibrous matrices regarded ideal candidate wound healing virtue excellent skin affinity good permeability air water demonstrated unique properties wound healing including anti inflammatory anti bacterial function promoting tissue growth reducing pain patients report feasibility developing composite fibrous matrices antimicrobial wound fibrous matrices loading different amount manufactured green ftir spectra indicated successfully loaded fibers composite fibers show smooth morphology diameter increases content increased interestingly incorporation significantly improved antimicrobial activity fibrous matrices without negative effect excellent biocompatibility moreover composite fibrous matrices showed good performance improving wound healing according data animal experiment findings suggest prepared natural green composite matrices combining merits promising candidate wound elsevier ltd rights reserved
high neighborhood social capital facilitate earlier diagnosis hiv higher rates linkage hiv care engagement multivariate analysis used examine whether social capital social cohesion social participation collective engagement associated lower year average prevalence late hiv diagnosis linked hiv care engaged hiv care within philadelphia united states census tracts higher average neighborhood social participation associated higher prevalence late hiv diagnosis linked hiv care lower prevalence engaged hiv care higher collective engagement associated lower prevalence linked hiv care findings different directions associations among social capital indicators hiv related outcomes underscore need nuanced research topic include longitudinal assessment across key populations
paper influence magnetic material degradation optimal design parameters electromagnetic devices presented investigation carried incorporating mechanical stress constitutive laws magnetic material single valued iron loss characteristics means parametric magneto mechanical model optimization problem formulated electromagnetic device reach predefined target performance application widely used electromagnetic device surface mounted permanent magnet synchronous machine studied presented results electromagnetic device easily adapting values flexible design parameters compensate effect magnetic material degradation achieve target performance paper help designers electrical machines improve quality machine design
studies third party perceptions intimate partner violence focus heterosexual relationships report male female aggression perceived negatively female male since gender gender victim consistently clear whether gender gender victim accounts effect present research manipulated gender victim unravel two hundred fifty one participants females read scenarios involving psychological physical aggression two males two females male female participants reported perceptions encounter character emotional reactions individual couple members physical aggression evaluated negatively psychological aggression participants evaluated encounter victim manner consistent stereotypical gender roles revealing concern female male victims greater male female perpetrators results implications programs aimed reduction intimate partner violence services programs developed perpetrators victims
paper presents novel surgical instrument integrated four degree freedom dof force sensor adopting capacitive transduction principle sensor enables direct sensing normal shear forces surgical instrument thus three dof forces single dof force measured feedback control robotic minimally invasive surgery systems sensor consists four capacitive transducers transducers including analog signal processing units embedded small surgical instrument four dof force sensing enabled thanks four capacitive transducers using force transformation method study instrument designed manufactured adaptable open source surgical robot platform called addition sensing system experimentally validated application using reference force sensor
aim study develop hand act rehabilitation device acquiring quantified data enhance power hand strength whole patient suffers hand injury directly exposed performing daily task therefore many hand aids developed overcome problem typical hand device able measure hand strength eventually increases functionality like hand used regular screening hand strength also preliminary ongoing assessment patients hand dysfunction trauma strain gauge based system transducer acts measurement system together arduino microcontroller instrumentation communication controlling applications integration strain transducer called load cell also made overall force sensor obtain readings hand movement microcontroller use information store analyze data card percentage difference observed hands across sample subjects support rule overall difference found combined dominant non dominant hand strength scores subjects observed
cortical spreading depression considered significant phenomenon human neurological conditions one key signatures development persistent cortical factors underlying reduction cerebral blood flow remain incompletely understood involve locally elaborated employed laser doppler rats together local pharmacological blockade approach test relative contribution cyclooxygenase cox derived response following administration non selective cox inhibitor completely inhibited response selective inhibition cox preferentially reduced early reduction selective cox inhibition affected later response blocking action using selective synthase inhibitor reduced initial decrease inhibition prostaglandin action using selective receptor antagonist blocked later phase results suggest long lasting following consists least two distinct temporal phases mediated preferential actions cox cox derived initial phase mediated cox involves followed later phase mediated cox
zinc finger type transcription factor regulates development white adipose tissue skin central nervous system immune system required proper differentiation embryos low amounts subcutaneous demonstrated mice lower body weight mice whereas expression marker genes comparable mice histological analysis indicated mice fed high fat diet much smaller white adipocytes lipid droplets liver respectively addition mice increased energy consumption standard high fat diets thus study identifies regulator energy metabolism unlikely functions contribute energy metabolism mice
work proposes improved technique design low power bit asynchronous successive approximation register analog digital converter adc proposed adc consists comparator digital control logic block analog dac comparator based improved positive feedback circuit built sample hold functionality enormous amount power implemented digital control logic block performing successive approximation algorithm totally external clock pulse outputs comparator given logic whose outputs serve internally generated clock ready signal trigger digital control block hence external clock required initiate digital control block making operation asynchronous implementing adc circumvent usage clock operate single low speed sample clock turn power required resilience sampling rates proposed adc designed simulated using cmos technology power operated single power supply achieves complete bit conversion relative accuracy capacitor ratio aperture conversion step respectively
paper presents potential developments artificial intelligent technologies welding manufacturing process shanghai university contains multi information fusion processing arc welding dynamical process intelligent computing welding process intelligent control methods welding process quality control artificial intelligent technologies welding robot systems robotic welding process application welding engineering ideas welding manufacturing technology welding manufacturing engineering presented paper researches applications technologies welding manufacturing
despite recent advances improving titers therapeutic proteins antibodies scale high yields achieved select mammalian hosts regardless host product strong promoters required obtain high levels transgene expression however promoters employed drive expression rather limited variety usually either viral derived screened empirically vector design begin move away viral parts employed systematic approach identify design new synthetic promoters using endogenous elements established workflow design elements analyzing profile specific cell line desired representative cell culture condition identifying key genetic motifs using bioinformatics used construct synthetic promoters building synthetic promoters using conventional dna synthesis molecular biology techniques evaluating performance synthetic promoters using model proteins resulting promoters perform promoter variants tested endogenous components design build test cycle also investigated underlying design rules transcription factor binding site arrangement synthetic promoters overall approach using guided workflow designing synthetic promoters facilitates construction high expression vectors immediate use current production hosts
background recent studies suggested interactions among several factors affect onset progression prognosis major depressive disorder study investigated childhood abuse neuroticism adult stressful life events interact one another affect depressive symptoms general adult population subjects methods total participants general adult population completed patient health questionnaire child abuse trauma scale neuroticism subscale shortened personality questionnaire revised life experiences survey self report scales structural equation modeling version single multiple regressions used analyze data results childhood abuse neuroticism negative evaluation life events increased severity depressive symptoms directly childhood abuse also indirectly increased negative appraisal life events severity depressive symptoms enhanced neuroticism structural equation modeling limitations recall bias study causal relationship clear study conducted using cross sectional design conclusion study suggested neuroticism mediating factor two effects childhood abuse adulthood depressive symptoms negative evaluation life events childhood abuse directly indirectly predicted severity depressive symptoms
article analyzes migration masculinity novel based true events story working class man called displays traditional conception masculinity based importance home family migrate germany achieve better future family feel man money economic independence way migration enhances sense masculinity hand novel also shows migration negatively affect mens traditional ideas masculinity male characters feel discriminated exploited jobs lose experience insecurity finally another consequence migration slight change main characters conception gender roles since ends supporting relationship
objectives study evaluated contributions obesity changes body mass index bmi mid life long term heart failure risk independent fitness levels background obesity low established risk factors however given inverse association obesity independent contributions bmi toward risk fully understood methods included participants center longitudinal study survived receive medicare coverage estimated metabolic equivalents mets according time associations bmi bmi change hospitalization age assessed applying proportional hazards recurrent events model failure time data results person years follow observed hospitalization events higher mid life bmi significantly associated greater risk hospitalization adjusting established risk factors hazard ratio confidence interval per higher bmi association attenuated adjusting per higher bmi accounted risk associated bmi bmi change significantly associated risk older age adjustment change conclusions higher bmi associated risk explained largely differences levels furthermore bmi change significantly associated risk adjusting changes findings highlight importance mediating bmi associated risk american college cardiology foundation
applying attachment theoretical perspective study examined relationship pattern childhood parenting experience adulthood depression mediated anger control data based national comorbidity study replication participants met dsm criteria lifetime major depressive disorder participants reported perceived anger control mediation hypothesis tested logistic regression models results showed childhood parenting experience significantly related major depressive disorder anger control significant indirect effect anger control detected bootstrap analysis supporting partial mediation hypothesis study represents first attempt examine mediating role anger control relationship early parenting depressive disorder findings study suggest early parenting experience important factor consideration research aiming understand sequential relationship anger control depression
paper presents effective way enhance secret key ratio machine learning based power analysis attack secure systems power supply current traces obtained varying atmospheric temperature possible values key collected power supply current traces pre processed using wavelet transform data normalization principal component analysis pca featured data samples used train probabilistic neural network network tested current trace obtained device attack correct key identified proposed method achieves success rate secret key cryptographic algorithm minimum number power traces compared existing methods machine learning technique
paper studied associations volatile organic compounds formaldehyde nitrogen dioxide carbon dioxide schools malaysia rhinitis ocular nasal dermal symptoms headache fatigue among students pupils eight randomly selected junior high schools malaysia participated formaldehyde measured diffusion sampling one week also air sampling class associations calculated level logistic regression adjusting personal factors home environment microbial compounds school dust prevalence weekly rhinitis ocular dermal symptoms respectively totally weekly headache fatigue indoor low range ppm indoor median formaldehyde concentrations one week respectively median indoor concentration one week respectively mean indoor concentration median median indoor levels class respectively associated ocular symptoms fatigue formaldehyde associated ocular symptoms fatigue associated fatigue headache conclusion formaldehyde schools risk factors ocular symptoms fatigue among students malaysia indoor outdoor levels often higher standard published elsevier
aim study investigate impact therapy morphological changes lipid rich plaques oct optical coherence tomography patients known chd coronary heart disease stratified ninety seven lipid rich plaques sixty nine patients received therapy underwent serial oct images baseline month month divided groups according risk score low risk group fibrous cap thickness measured part times baseline characteristics different groups sustained increased baseline month month follow group respectively group respectively lipid index significantly decreased group group incidence decreased statistically group group patients known chd benefit therapy stabilizing lipid rich plaques patients moderate high benefit within first year event time
objective assess observational data low testosterone men independent risk factor high fasting glucose diagnosis type diabetes methods multivariate analysis data male air force veterans completed six medical examinations years results low testosterone moderately related high independent age obesity low testosterone weak predictor diagnosis conclusions men low testosterone independent risk factor high comparable aging obesity low testosterone weak predictor diagnosis
paper presents observational study conducted public environment investigating childrens engagement social robot within play scenario play system designed order address challenges evaluating child robot interaction exploiting advantages ubiquitous robotics ambient intelligence multimodal multi sensory perception system performed successfully childrens play centre robot able dynamically adapt gender changing gendered voice match gender child analyzing free play children results obtained confirm hypothesis gender segregation within child robot interaction findings important considered designing robotic applications children order increase robots perceived acceptance engagement
report unusual combination anomalies head female fetus authors examined whole body paraffin sections female fetus similar weeks gestation particular focus head region cranial autonomic ganglia nasal olfactory cells orbital muscle investigated using immunohistochemistry tyrosine hydroxylase intestinal peptide smooth muscle actin expression surface gross anatomy fetus appeared normal left lacked lens otherwise normal orbital muscle thick located side muscles conversely muscles made cluster side orbit small due extended lateral process contrast small process mandible bilateral mandibular bases overlapped thin thick provided almost flat anterior cranial base nasal olfactory cells cranial autonomic ganglia appeared normal major anomaly observed brain changes anatomy orbital muscle probably lost normal bony attachment appeared push muscles gene function redundancy rather mutation explain present restricted anomalies mandible process wiley liss inc
problem neurobiology recent discoveries molecular biology genetics cognitive sciences present report man body intellectual perception others social morality affects governed neuronal things simple methodology try answer question author going use opposition explain understand long standing often debate concerns ontology two modalities different thus methods mind explain nature submitted principle causality understand life back sphere sense results debate explain understand far simple author draw conclusions questioning speech promising neurobiology believe explain including actions name neurobiological reason case history already fate neurobiological shaped man neurobiological speech based mechanism goes round opposite reporting say precise perception consciousness consciousness appropriate place say differently intellectual topic appropriate consciousness takes place remain one exist thus need immediate permanent help one process purely event brain actions gestures brief allowed live take place takes place finally brings explanation always leaves something phenomenon life example alcoholic significant change intellectual mechanisms responsible alcohol addiction alcoholic drink makes written history much importance alcoholic began thinking cerebral dysfunction lives life shape indeed receives message question indeed receives message feeling question force feel brain passes appears brain world lives also condition without objects cultivated without world presence one existence understanding neurobiological explanation alcohol addiction concern knowledge ignore life means gap live alcoholic reduced cerebral dysfunction life relation capable taking using real life experience psychopathology implications going show big importance reduction comes understanding man sick reality constantly deal global complete man human fate conclusion science brings news discovered domain keep always mind life remains deeply moving without event allows live air become technical scientific world like elsevier masson sas rights reserved
study synthesized series structures characterized spectral nmr nmr infrared spectroscopy liquid chromatography mass spectroscopy elemental analysis antimicrobial activity carried serial dilution method gram positive bacteria staphylococcus aureus streptococcus gram negative bacteria escherichia coli pseudomonas aeruginosa three fungi candida albicans aspergillus aspergillus vitro compounds showed potent antimicrobial activity tested microorganisms grades cytotoxicity studies human cervical cancer cell line hela mouse embryonic fibroblast cell line indicated compounds showed low cytotoxicity
new renewable energy drawing attention fossil fuels depleted solar cell type new renewable energy produce energy daytime contaminants attached onto surface solar cells module following yellow dust dust low efficiency solar cells caused reducing solar energy contaminants thus important remove contaminants attached surface solar cell modules study surface properties glass substrate coated functional nano thin films analyzed microwave natural drying conditions
background serum uric acid shown predictor renal disease progression studies study aims test whether renal function normalized serum uric acid superior serum uric acid predictor incident chronic kidney disease type diabetes mellitus patients methods study type diabetes mellitus patients estimated glomerular filtration min included renal function normalized serum uric acid calculated using serum uric acid creatinine cox regression analysis used estimate association serum uric acid renal function normalized serum uric acid incident chronic kidney disease results total patients developed chronic kidney disease greater median follow older ages longer diabetes duration lower estimated glomerular filtration rate baseline decline rate estimated glomerular filtration rate positively correlated serum uric acid creatinine serum uric acid moreover multivariate analysis revealed serum uric acid independent risk factor incident chronic kidney disease whereas serum uric acid creatinine ratio significantly associated incident chronic kidney disease independently potential confounders including baseline estimated glomerular filtration rate conclusion serum uric acid creatinine ratio better predictor incident chronic kidney disease type diabetes mellitus patients
novel switching circuitry fully differential wave applications presented structure proposed switching architecture includes cmos transistors distributed active transformer minimise chip size innovative topology based lumped components investigated resulting total size performance designed switch validated within dual mode local oscillator distribution circuitry band
doubly salient electrical generator characteristics easy control high reliability used high speed field satisfy low speed high power characteristics direct driven wind power paper first analyzes control strategy used studies novel direct driven doubly salient electrical wind generator rotor finite element analysis fitted area wide speed load range simulation results matlab demonstrate positive electrical characteristics
review discusses unmet needs patients attention deficit hyperactivity disorder adhd adulthood although awareness recognition adhd children adolescents adults improved recent years often interruption management disorder adolescent patients transition adult health care services review following objectives identify key issues patients adhd without early diagnosis face transition adulthood review current clinical practice country specific approaches management transition adulthood patients adhd discuss challenges facing clinicians patients drug treatment adhd initiated review current adhd guidelines transition management hong kong singapore south korea turkey africa examine economic consequences associated adhd review suggests transition period adult adhd area transition period plays important role regarding adhd symptoms perceived acted upon adult psychiatrists studies needed explore characteristics transition period fraction adolescents mental disorders adulthood especially adhd crucial identify characteristics target appropriate interventions beginning course illness continues low recognition adult adhd severe lack medical services equipped diagnose care patients adhd child adult services
objectives present study following ones study use drugs prosocial behaviour problem solving skills respect age gender analyze association prosocial behaviour problem solving skills use drugs descriptive cross sectional study performed amongst sample students spanish secondary education males age range years statistically significant differences found concerning alcohol use prosocial behaviour respect gender concerning alcohol cannabis use respect age controlled effect age sex regression models variable best predicted alcohol cannabis use prosocial behavior results study enhance importance tailored interventions based promotion prosocial behaviours fundamental protective factor substances use alcohol cannabis amongst adolescents
expanded genetic testing mutations led identification reproductive aged women test positive mutation impact attitudes decisions relationships childbearing use genetic diagnosis prenatal diagnosis cross sectional survey administered self reported carriers investigate knowledge status influences issues mean age test disclosure years reported personal history cancer women felt pressure get married women whose families complete reported carrier status impacted decision biological children women history cancer likely report knowledge status impacted decision child fifty nine percent thought offered mutation carriers thought offered conclusion knowledge status impacts attitudes regarding relationships childbearing carriers believe offered carriers study suggests carriers desire benefit reproductive counseling test disclosure
much attention given developing nanocomposites layered owing great need advanced materials engineering fact pure polymers present behavior properties needed certain applications within context objective study influence molecular weight obtaining nanocomposites national mixture processed twin screw characterized ray diffraction xrd heat deflection temperature possible observe xrd obtain structure partially studied systems found nanocomposites higher pure polymer values systems significantly higher pure
paper novel grounded negative inductance simulator proposed using one operational amplifier active element one capacitor three four resistors passive elements properties proposed negative inductance simulator verified using cmos current feedback operational amplifier based realization pspice proposed circuit also tested experimentally verify theoretical results application cancellation unwanted inductance tested using proposed inductance simulator
transforming growth factor atrial fibrillation growth factor tgf important factor induces atrial fibrosis atrial fibrillation purpose study evaluate association tgf level clinical factors catheter ablation investigate impact tgf level outcome methods prospective study included patients persistent group paroxysmal group control group patients underwent followed months group highest tgf levels patients early recurrence defined episodes atrial within month period detected patients recurrent period detected patients multivariate analysis low tgf level independent factor associated recurrent moreover recurrence ratio higher low tgf group high tgf group patients patients log rank test associated higher tgf level moreover lower tgf level patients cause recurrent
conduct simulations device structures typical electron beam induced current imaging solar cell structures type absorber layers charged grain boundaries large signal enhancement found near depleted positively charged grain boundaries simulation contrast previous claims solar cell performance drops contrast little contrast seen cell performance improves accumulated negatively charged grain boundaries introduced explore impact doping level grain boundary charge provide insight design improved thin film solar cells
paper proposed new test function construct exact solitary wave solutions nonlinear evolution equations dimensional equation taken example illustrate effectiveness proposed test function aid maple program calculation carried obtain new exact solutions said equation exact solutions obtained enrich solution structure higher dimensional nonlinear wave equation method applied nonlinear evolution equations
currently several irreversible inhibitors targeting residue preclinical clinical development however inhibitors also targeted egfr bear highly similar active cysteine residues structure based drug design approach discovered highly potent irreversible inhibitor compound displayed high selectivity profile score among kinases mutants concentration compound completely abolished activity ray crystal structure cysteine serine mutation mediated rescue experiment confirmed irreversible binding mode also inhibited auto phosphorylation cell cycle phase induced apoptosis cells believe features make good pharmacological tool study related pathology elsevier masson sas rights reserved
report case patient administration probiotic containing saccharomyces demonstrated strain relatedness yeast probiotic capsule yeast causing fungal infection using genomic proteomic typing methods study questions safety preventative elsevier inc rights reserved
essential living organisms involved several vital cell functions biosynthetic pathway regulation established sense enzyme acts one controlling factors entire pathway work assessed inhibition alpha alternate observed fungal growth production reduced inhibition completely restored addition exogenous actually increasing concentrations growth media negatively affected production corroborated downregulation genes involved biosynthesis also studied metabolism alternate goal finding new targets compromise growth production capacity sense tested two different analogs observed partially controlled viability vitro vivo using tomato plants finding strategies design new substances becoming matter interest resistance problems emerging published elsevier ltd
large number asthmatic patients particularly females present inadequate disease control depressive symptoms common asthma related poor disease control mechanism association still unclear poor quality sleep frequently observed also manifestation depression related uncontrolled asthma study aimed investigate relationship depressive symptoms sleep quality asthma control cross sectional study women previous diagnosis asthma reference center brazil depressive symptoms assessed beck depression inventory bdi quality sleep evaluated pittsburgh sleep quality index daytime sleepiness sleepiness scale asthma control asthma control test act inadequate asthma control excessive daytime sleepiness depressive symptoms associated poor quality sleep inadequate asthma control regression analysis showed depressive symptoms sleep quality independent predictors level asthma control asthma control women independently associated depressive symptoms quality sleep suggesting patients benefit simple measures promote healthy sleep behavior sleep hygiene also routine screening depression relevant particularly poorly controlled cases
integration optical modulators cmos drivers crucial high speed silicon photonic reach full potential low cost low power electronic photonic integrated systems present cmos driven multi level optical transmitter implemented using commercially available lateral junction process uses modulator segmented increase speed lower required power per segment basis level achievable cmos multi channel driver designed implemented cmos providing swing push pull configuration binary data cmos input manipulated via digital logic produce proper drive signals generate four level pulse amplitude modulation optical signal multi level modulation achieved using binary signals input dac less optical electrical circuits shows good agreement experiment reliable transmission achieved without post compensation using
background oncology nursing often source substantial stress nurses many nurses particularly novice nurses inadequate preparation care patients end life families unless nurses prevent manage work related stress using effective coping strategies oncology nursing staff continue suffer burnout compassion fatigue objectives purpose article identify stress levels stressful factors nurses working oncology outpatient units explore coping behaviors work related stress oncology staff nurses outpatient units methods descriptive cross sectional design used identify stress levels stressful factors outpatient oncology nurses investigate differences stress levels among nurses demographic characteristics explore coping behaviors nurses study participants included licensed practical nurses completed nursing stress scale three open ended questions demographic questionnaire findings highest sources stress workload patient death demographic variables age work experience nursing showed significant positive relationship work related stress scores three frequently used coping behaviors taking time self continuing education programs stress management highly recommended outpatient oncology nurses supported tailored interventions multiple levels help find effective coping strategies develop self care competencies although younger less experienced nurses lower mean stress scores older experienced nurses continuing education programs tailored interventions helpful oncology nursing staff
context coffee food product coffee industry studied active ingredient skin care products due high potential antioxidant activity low cytotoxicity another food waste used ingredient promising characteristics obtained sativa antioxidants content high objective aim study evaluate characterize new body formulation containing two food products extracts materials methods different parameters rheological behavior color antioxidant content microbiological analysis body cream formulation containing products formulation without extracts evaluated stability study days different temperatures moreover vitro cell toxicity vivo skin safety protective effects also assessed results formulation showed stable physical properties antioxidant activity days storage vitro toxicity screened two skin cell lines fibroblasts keratinocytes toxicity reported vivo test carried showed respect effects formulation regarded safe topical application skin improved days use also considering consumer acceptance volunteers classified conclusions formulation stable safe topical use adverse side effects observed application period testing improving skin protective properties
purpose randomized controlled trials reducing high patients polycythemia vera protects cardiovascular disease cvd events whereas increasing anemia patients causes cvd events influenced environmental lifestyle factors given limited knowledge concerning drivers took approach identify drivers methods used environment wide association study identify environmental lifestyle factors associated older chinese adults mean age years cohort study evaluated role nutrients environmental contaminants two metals available participants six lifestyle factors relation adjusted sex age recruitment phase socioeconomic position results mutually adjusted model vitamin serum calcium serum magnesium alcohol use associated higher whereas physical activity associated lower conclusions despite difficulty causality finding expected vitamin physical inactivity novel factors serum calcium serum magnesium alcohol use strongly associated illustrates utility environment wide association study generate hypotheses regarding potential contribution modifiable exposures cvd elsevier inc rights reserved
fungal specific cells described biomarker invasive influence sample storage detection cells assessed six hour delay prior isolation associated decrease cell viability alterations cellular composition sample results reduction specific cells due reduced assay sensitivity increased background values samples prompt cell measurement feasible isolated pbmcs frozen degrees degrees processed later comparable assay reliability mean value fresh pearson coefficient
physiological circumstances various mechanisms support protection self structures immune responses however quantitative qualitative changes regulatory immune cells mediators auto reactive immune responses upon susceptible genetic background along presence concomitant etiological factors autoimmune disease develop transplant immunology mechanisms also critical since balance reactive effector cells regulatory immune cells ultimately determine whether graft accepted rejected better understanding immunological tolerance potential immune regulatory processes crucial developing effective therapies autoimmune diseases organ transplantation review focus novel insights regarding impaired immune regulation relevant factors contributing development auto reactive graft reactive immune responses autoimmune diseases transplant rejection respectively also address promising approaches modification immune regulatory processes mechanisms autoimmunity solid organ transplantation beneficial future therapeutic strategies elsevier rights reserved
although intimate partner violence ipv prevalent among women living hiv negatively impacts health studies examined ability aids service organisations address ipv study used qualitative approach identify facilitators barriers addressing ipv female clients united states depth interviews conducted march august staff members female clients reported current past history ipv interviews audio recorded transcribed analysed using constant comparative method data identify barriers addressing ipv organisation provider client levels include suggestions clients providers improving access care client provider suggestions differed areas providers structural changes increased training ipv provided organisation clients highlighted importance personal relationships staff increase client disclosure ipv experiences given differing opinions clients staff consider involving women histories ipv process programme policy development unique opportunity provide comprehensive holistic care addressing ipv extent able address ipv strategies increasing ability warrant greater attention administrators researchers
exhaust gas internal combustion engine provides favorable conditions waste heat recovery system highest potential achieved rankine cycle heat recovery technology experimental studies investigate full scale systems using water based working fluids effects performance operation rankine cycle heat recovery system paper discusses experimental results practical challenges system utilizing heat exhaust gas recirculation system engine results showed point trade offs maintaining adequate pressure achieving acceptable cooling water used system geometric compression ratio together steam outlet timing caused high compression inlet pressures bar therefore required stable power output high pressures increased pump power reduced cooling point effects simulations indicated reducing compression ratio allow lower steam supply pressures without adversely affecting power output
coated thermoelectric refrigeration means infrared stealth target study infrared characteristic target coated thermoelectric refrigeration foundation infrared stealth technology coated thermoelectric refrigeration infrared characteristic model target coated thermoelectric refrigeration established considering complex energy exchange target sea structure transfer character thermoelectric refrigeration analyze effect current hot side transfer coefficient surface temperature target making corresponding program depending target background temperature consistent standard ideal current day designed
autophagy herein cellular stress response survival pathway responsible degradation long lived proteins protein aggregates damaged organelles order maintain cellular homeostasis consequently abnormalities autophagy associated number diseases including disease parkinsons disease cancer according current view autophagy seems serve tumor suppressor early phases cancer formation yet later phases autophagy support facilitate tumor growth spread contribute treatment resistance therefore autophagy considered stage dependent dual player cancer micrornas mirnas endogenous non coding small rnas negatively regulate gene expression post transcriptional level mirnas control several fundamental biological processes autophagy exception furthermore accumulating data literature indicate dysregulation mirna expression contribute mechanisms cancer formation invasion metastasis affect responses chemotherapy radiotherapy therefore considering importance autophagy cancer biology study autophagy regulating mirna cancer allow better understanding malignancies lead development novel disease markers therapeutic strategies potential provide study cancer related mirnas also implicated autophagy regulation review focus autophagy mirna cancer connection discuss implications cancer biology cancer treatment
astrocytes important normal brain functioning astrocytes metabolic regulators brain exert many functions preservation blood brain barrier function clearance toxic substances generation antioxidant molecules growth factors functions fundamental sustain function survival neurons brain cells reasons protection astrocytes become relevant prevention neuronal death brain pathologies parkinsons disease alzheimers disease stroke neurodegenerative conditions currently different strategies used protect main functions neurological diseases including use growth factors steroid derivatives mesenchymal stem cell factors nicotine derivatives computational biology tools moreover combined use experimental approaches bioinformatics tools ones obtained system biology allowed broader knowledge protection normal pathological conditions present review highlight recent paradigms assessing protection using experimental computational approaches discuss used study therapies brain pathological conditions
kidney transplant recipients subjected immunosuppressive therapy enhance hepatitis virus replication leading cirrhosis hepatocellular carcinoma hcc aim study assess prevalence outcome hcc case control study patients chronic hbv hcv infection underwent kidney transplantation subsequently developed hcc compared control group patients chronic hbv hcv infection matched gender age hcc diagnosis receive kidney transplantation among hepatitis fourteen developed hcc period prevalence age hcc diagnosis controls time transplantation hcc diagnosis six related hbv six hcv two infection hbv hcv immunosuppressive therapy comparable hbv hcv hbv hcv patients diagnosis patients met criteria control group alpha levels tumour characteristics treatment modalities comparable groups patient survival hcc diagnosis compared controls survival hcc diagnosis significantly worse compared patients hbv hcv prevention crucial based viral eradication suppression transplantation
successful detection small rnas rna similar length northern blotting dependent improved northern blot protocols combine chemical rna ethyl positively charged membranes use native polyacrylamide development highly sensitive specific probes modified locked nucleic acids protocol show northern blot detection rnas labeled dna probes highly sensitive specific method hands sensitive using corresponding dna probe end label
recent years number studies conducted analyze wind induced vibrations bridge using computational fluid dynamics cfd previous studies limited analyzing two dimensional sections three dimensional analyses entire bridges yet performed study cfd program fluid structure interaction developed perform analysis cable stayed bridge fem formulated least squares method arbitrary lagrangian method used perform fluid structure interaction cfd spectral representation method used generate time series turbulence applied inlet boundary condition used reduce large computing time analysis model existing cable stayed bridge contains ambient atmospheric region used calculate dynamic responses bridges detailed flow wind results cfd analysis bridge compared results conventional frequency domain analysis results essentially good agreement conventional analysis numerical method developed study efficient alternative wind tunnel tests verifying wind flow wind loading structural vibrations american society civil engineers
social cognitive intervention developed delivered credit course improve mental distress university students based findings previous health survey showing notable mental distress among future teachers intervention included increasing information substances used stress reduction skills development stress reduction methods improving skills communication problem solving students participated previous health survey targeted mental status participants assessed questionnaire male mean age years male mean age years intervention specifically self efficacy outcome approximated trait measure sense coherence psychological distress measured item general health questionnaire validity two versions study mental illness general health care psychological medicine intervention compared intervention psychological distress reduced among participants non significant improvement occurred mean score sense coherence mean points points intervention produced modest significant decrease psychological distress students cost per point improvement mental distress intervention first example translation social cognitive theory practice among students higher education integrated curriculum standardized optional course
based cellular automata model two cellular automata model proposed driving behavior difference difference vehicles accelerations moving state starting state taken account furthermore vehicles motion refined using small cell one meter long accompanied coming traffic management measure two highway traffic model containing work zone presented road divided normal area merging area work zone vehicles different areas move forward according different changing rules position updating rules simulation found density small cluster length front work zone increases decrease merging probability suitable merging length appropriate speed limit value recommended simulation result form speed flow diagram good agreement empirical data indicates presented model efficient partially reflect real traffic results meaningful traffic optimization road construction management elsevier rights reserved
review highlights story methotrexate drug discovered treatment childhood leukemia became mainstay treatment standard care rheumatoid arthritis also found useful several additional related diseases several synthetic disease modifying drugs treating discovered use low dose based sound reasoning observations made difference high dose used treatment childhood malignancies used rheumatology emphasized
dynamic reduced models rms derived rigorous models highly desired dynamic simulations useful software tool named developed automatically generate data driven rms high fidelity dynamic models allows user input output variables sample input space generate sequences step changes launch high fidelity model simulations fit simulation results finally visualize validate decoupled net nonlinear system identification model used main type enhanced model nonlinear multiple input multiple output dynamic systems options double pole formulation handle fast slow time scales pole value optimization tool successfully used generate rms highly nonlinear reactor system two time scale bed reactor capture elsevier ltd rights reserved
atopic diseases like asthma allergies various proteins among widespread chronic diseases newborns allergy prone skewed immune response increasing scientific reports indicate mothers immune system plays crucial role mediating development fetal infant immune responses glands part integrated mucosal immune system confined production antibodies particularly targeted pathogenic agents mothers environment later encountered newborns passive immunity mothers milk critical newborns immune maturation thus understanding maternal influence childhood atopic risk newborn immune maturation suggest novel treatment prevention strategies probiotics proposed imbalance allergic diseases however mechanism remains largely unknown feeding probiotics mothers offspring prenatal postnatal periods inhibit allergies newborns possible preventive approach atopic diseases hence present review focuses role feeding probiotics mothers pregnancy lactation newborns post weaning periods possible modulators activation maternal infant immune response allergy prone biased newborn system
objective study designed assess emergency contraception knowledge attitude practices among female students university methods descriptive cross sectional survey conducted female students recruited cluster sampling various university departments predefined questionnaire used interview students participate survey data collected analysed software variables compared chi square test limit significance results half students familiar emergency contraception method informed friends media already used method least following unprotected sexual intercourse age reported irregular sexual partners conclusion students familiar easy access method however repeated use method highlights need better information students concerning classical methods contraception awareness campaign conducted campus order reduce currently high rate non medical abortion
paper applied hot water induced system foot based medicine principle concerned notion head kept warm objective study determine influence cardiovascular system physiological parameters inherent thermal stimulation temperature degrees therefore relevant physiological parameters blood flow heart rate blood pressure oxygen saturation leg temperature associated cardiovascular system selected analysis experimental equipment used study included hot water system designed pre post experimental conditions temperature degrees assessed healthy volunteers days pre post measurements obtained minutes transition results experiments follows blood flow min inc heart rate inc blood pressure mmhg max min oxygen saturation inc decrease inc increase according results hot water applied foot appear exert influence cardiovascular system also appears generally improve human metabolism
distributed computing strategy network wireless sensors emerged promising application order enable real time structural health monitoring previous studies distributed computing strategy consider relatively simple operations like modal parameters identification frequencies modal shapes directly assess structural health condition many practical engineering applications article focuses developing distributed computing strategy techniques wireless sensor networks used direct stiffness estimation structural damage locations extent improved frequency domain regression method proposed detect quantify damage frame structures proposed method static condensation technique adopted reconstruct rotational responses joints considered inputs estimate stiffness therefore improved method provides practical accurate tool structural damage detection numerical simulation five story two bay frame structure demonstrates proposed damage detection method using limited number wireless sensors identify locate quantify structural stiffness changes accurately
korea child welfare act made required national study estimating occurrence rate child abuse neglect every years present study reports major findings first national study conducted aim study estimate prevalence child physical psychological maltreatment korea explore basic characteristics associated incidents household surveys administered caregivers focal children school age older estimated prevalence using parent child conflict scale developed occurrence rate korea instances differing household income poverty status size region children experienced physical psychological maltreatment likely abuse siblings domestic violence implications findings discussed recommendations made research
water pollution major concern societies like pakistan pharmaceutical industries amongst contributor industrial waste present study addresses generation oxidative stress caused months exposure pharmaceutical wastewater rats response oral treatment vitamin potent antioxidant rats randomized five groups named negative control pharmaceutical wastewater vitamin oxidative damage rats evaluated estimation activities total superoxide dismutase sod catalase cat concentration hydrogen peroxide liver kidney blood plasma exposure pharmaceutical wastewater significantly decreased activities sod cat concentration liver kidney blood plasma exposure pharmaceutical wastewater exhibited maximum decline sod activity activity reduced protein plasma kidney liver respectively exposure wastewater minimized activity cat hemoglobin protein blood kidney liver respectively treatment vitamin significantly increased activity sod cat however increase concentration also observed vitamin exposed rats histopathology kidney revealed necrosis renal epithelial cells congestion showed infiltration inflammatory cells cellular breakdown areas lung sections exhibited suggesting decline lung function anatomy liver also compromised due severe degeneration cellular swelling present study concluded pharmaceutical wastewater induced severe oxidative stress wistar rats histopathological lesions several vital organs suggesting high toxicity non enzymatic antioxidant vitamin ameliorate oxidative stress induced pharmaceutical wastewater
large number urban infrastructure renewal activities occurring cities throughout world leads social economic environmental impacts communities vicinity coordinated effort required activities paper presents framework enable temporal time based coordination water road intervention activities intervention activities include routine maintenance renewal replacement physical assets coordination framework considers life cycle costs infrastructure level service risk exposure system operators model enables infrastructure asset managers trade options delaying versus bringing forward intervention activities one system order executed conjunction another located system right way framework relies combination meta heuristics goal based optimisation order demonstrate applicability framework case study major infrastructure egypt taken example results show framework scaled include infrastructure systems located right way like electricity gas provided information shared among entities
internal users main causes anomalous behaviors communication network even traditional security present internal attacks lead network leakage sensitive information article propose intrusion detection prevention system based traffic analyzer global network view software defined networks provided main contributions dynamic elastic resource provision traffic analyzing machines demand real time detection attacks simple algorithms implemented policy language network events iii immediate reaction attacks malicious flows close sources near optimal placement sensors proposed heuristic positioning sensors network infrastructure shared multi minimum number sensors developed prototype proposed system evaluated virtual environment future internet testbed security fits evaluation system attack shows guarantees legitimate packets maximal link rate reducing maximal network delay caused attack reaches bandwidth gain compared conventional approaches even attackers legitimate acting addition system reduces sensors number keeping full coverage network flows
current study investigated use various information communication technologies ics related social capital parenting efficacy among parents youth specifically using structural equation modeling examined direct indirect associations ict use social capital parenting efficacy using data parents youth parents ict use directly associated social capital direction association differed ict parenting efficacy positively associated parents social capital also parents ict use directly indirectly associated parenting efficacy parents using checking news events online frequently likely report higher parenting efficacy use negatively associated parenting efficacy results suggest parent family life educators optimize education programs utilizing different based purpose program elsevier ltd rights reserved
gesture recognition gesture easy influenced nonlinear factors illumination motion etc based analysis svm classification method effect practical application paper proposes gesture method based combination nonlinear support vector machine svm linear discriminant analysis svm first works gesture recognition system constituted multiple surface electrode sensor microcontroller acquisition unit computer second get best classification feature image linear discriminant analysis feature extraction finally carry classification recognition gesture characteristic vector applying nearest neighbor classifier time compared classification algorithms get advantages disadvantages algorithm paper experimental results show svm gain higher recognition rate provide theoretical data support researcher artificial hands control choose appropriate means recognition
recent research demonstrates although risk disease disability clearly increases age poor health need inevitable consequence aging healthy lifestyle influential genetic factors assisting older adults avoid decline deterioration traditionally associated aging many effective strategies reducing disease disability widely health partnerships community based nurse managed health promotion chronic disease care management program community residing older adults program base supports multidisciplinary collaborative practice model responded health needs members community high risk developing chronic conditions preliminary comparisons health status program participants national norms demonstrate report better general health performance roles social functioning strongest correlations occurring general health vitality general health role physical addition participants doctor visits per year comparison office visits national comparison group hospital days per year comparison hospital days referenced population collaborative partnership model replicated cost effectively communities
common injury variety different athletes especially involved contact sports played rigid surfaces caused injury joint resulting attenuation complex treatment generally consists measures rest ice anti inflammatory drugs sole walking casting recent increase use biologics platelet rich plasma autologous conditioned plasma treatment variety orthopaedic conditions study reports cases treated combination autologous conditioned plasma case presentations followed literature review use biologics treatment sports injuries elsevier inc rights reserved
programming specific sites stack used extensively software developers knowledge sharing acquisition due cross reference questions answers note users also reference external site paper sharing refers internal within site unless otherwise stated knowledge site forming large knowledge network stack developers share community feedback knowledge shared unique topological semantic properties resulting knowledge network stack knowledge network become stable reach stability answering questions help software engineering community better understand knowledge diffusion process programming specific sites like stack thereby enabling effective knowledge sharing knowledge use knowledge representation search community previous work focused analyzing user activities sites mining textual content sites article present methodology analyze sharing activities stack use open coding method analyze users share stack develop set quantitative analysis methods study structural dynamic properties emergent knowledge network stack also identify system designs community norms social behavior theories help explain empirical findings study obtain depth understanding knowledge diffusion process stack expose implications sharing behavior site design developers use knowledge stack future research knowledge representation search
natural lung aging marked molecular changes occur development maturation late life decline cellular whole organ level degenerative changes hallmark natural aging shorter telomeres increased expression cellular senescence markers increased dna damage oxidative stress apoptosis accompanied diminished elasticity reach pathological levels aging humans form chronic respiratory disease aging strongly correlates development incidence chronic respiratory diseases including cancer idiopathic pulmonary fibrosis strongly linked development chronic obstructive pulmonary disease lung failure due aging loss lung stem cell regenerative capacity within distinctive stem cell found within compartment lung current knowledge identity function stem cell compartments largely drawn variety transgenic spontaneously mutated mouse models characterized rapid rates aging used examine regeneration injury context natural accelerated aging much work focused failure epithelial cell populations key component aging process additional studies shown aging global phenomenon lung also impacts resident endothelial mesenchymal immune cell populations review examine aging process dependent specific changes molecular pathways within multiple lung cell populations karger basel
psychotic disorders severe psychiatric conditions patients difficulties identifying facial expressions appear highly sensitive presence emotional yet study investigated whether perceptual load modulates interference emotional goal test whether psychotic patients sensitive irrelevant emotional stimulus even task demands high amount attentional resources twenty two participants schizophrenia disorder twenty two healthy controls performed target letter discrimination task emotional task irrelevant stimulus angry happy neutral facial expressions target presented among similar low perceptual load different high load participants discriminate target letter ignore facial expression results showed patients prone distraction task irrelevant stimulus especially high load suggesting difficulties attention control moreover psychotic patients happy faces caused higher interference task whereas neutral angry faces resulted less interference findings provide innovative approaches regarding attentional deficits social contexts patients schizophrenia spectrum disorders
negatively charged events often remembered high accuracy less prone memory distortions however whether applies individuals high emotional involvement understood explore issue present study investigated whether internalizing depressive anxious trait affected occurrence memory errors emotional neutral events recognition memory paradigm consisting material presented two groups young adults one high scores depression anxiety scales one control group results showed increased proportion causal false memories inferring seen cause viewed effect depressive anxious group encoded events negative neutral important false memories occurred characterized experience conversely control participants negative material found protect memory distortions compared neutral material results discussed light previous research memory distortions individuals emotional disturbances highlight possibilities offered using new paradigm studying false memories elsevier ltd rights reserved
background suggested dementia caused neuronal damage due chronic inflammation peripheral sources oral cavity periodontal disease objective aim review assess risk dementia cognitive impairment associated chronic periodontitis multiple tooth loss materials methods extensive search electronic databases articles relation periodontitis tooth loss dementia published april conducted experimental human studies provided description consistent multiple tooth loss chronic periodontal disease cognitive impairment obtained validated methods selected data extracted articles included study design country origin sample size methods used assess periodontitis cognition average age baseline number years follow scale used assess quality human studies results literature search yielded articles independently screened articles included review four human studies reported association subsequent dementia multiple tooth loss one human study reported chronic periodontal disease associated dementia eight experimental studies demonstrated association cognitive impairment tooth loss conclusion literature chronic periodontitis multiple tooth loss risk factors dementia remains inconclusive randomised clinical trials association periodontitis dementia uniform criteria evaluation diagnosis periodontitis warranted
cell activating factor tnf family critical survival maturation cells play role pathophysiology chronic nasal study nasal tissues enrolled patients asthmatic non asthmatic patients ten control subjects respectively immunoreactivity examined using immunohistochemistry staining mrna expression aid examined using real time protein levels ige measured using elisa assays system respectively found numbers cells cells cells cells plasma cells significantly increased tissues compared control groups concentrations ige tissue also significantly increased tissues compared control groups protein level significantly associated ige levels concomitant asthma patients findings indicate expression significantly increased patients inflammatory load tissues regulating cell mediated response
imbalances excitation inhibition synaptic transmission neural circuits implicated autism spectrum disorders excitation inhibition imbalances frequently observed animal models autism spectrum disorders correction key autistic like phenotypes animals results suggest excitation inhibition imbalances contribute development maintenance autism spectrum disorders represent important therapeutic target
years domestic induction becoming increasingly popular due specific features safety quick warming high efficiency features derive fact heating directly generated vessel unlike traditional contact heating methods specially later feature attracting attention researchers devoted highly efficient power electronic systems extensive electricity lack availability future society forces think another alternative solar energy provides cost effective solution energy problems paper presents cooking system using solar energy faster easier cheaper compared cooking system paper presents simulation perturbation observation technique extract maximum energy photovoltaic systems controller get accurate smooth power control resonant converter main desired features designing inverter domestic induction heating smooth output power control efficiency high efficiency voltage control induction prototype designed operating switching frequency khz frequency line rms voltage line frequency output pulse width modulation pwm technique used providing pulses via microcontroller hardware implementation used along driver circuit particular features smooth voltage control reduction conduction loss high efficiency matlab simulation control solar controller resonant converter presented
background diagnosis sports related often dependent athlete self reporting symptoms suggested improving youth athlete knowledge attitudes toward increase self reporting behaviour objective study determine novel educational program improves knowledge attitudes among cohort elite male players methods fifty seven male level players mean age years recruited local community participant completed modified version knowledge attitudes survey student version immediately educational presentation follow sessions arranged months presentation assessed retention knowledge attitude changes results forty three players completed three surveys knowledge attitude scores significantly increased pre post presentation respectively long term follow knowledge levels remained significantly higher baseline mean attitude scores also increased follow however increase statistically significant conclusions educational program led immediate improvement knowledge attitudes among elite male players increased knowledge maintained long term follow improved attitude future studies investigate whether similar educational programs influence symptom reporting incidence addition focus maintain improved attitudes
many years north american fish common name regarded single widespread morphologically variable species occurring rivers throughout much valley geographically adjacent eastern slope west basin texas new mexico mexico completed morphological study western populations results appeared thereafter published form demonstrated existence five valid species west river name shown restricted population occurring geographically adjacent san system northeastern mexico considered populations throughout middle valley major single morphologically variable species also indicated populations eastern slope represent complex species genetic confirmation conclusions regarding western species appeared publication also showed western populations presently recognized genetically much complex previously considered meanwhile present authors involved study eastern populations genetic summary eastern coast species published powers based findings four species recognized southeastern identified species although formal taxonomic descriptions included genetic data combination morphometric morphological data presented herein form basis revised classification eastern populations including formal descriptions four new species eastern coast
culture universal phenomenon interest culture pregnancy focused medical care psychological aspects normative development purpose article examine normative gestational experiences using framework broaden build model culture positive pregnancy youth development review involved studies books book obtained electronic databases focusing parental attitudes available care parental expectations cultural values nutrition likely affect several protective factors emerged positive expectations early prenatal care protective cultural values appropriate nutrition sensitive health care providers supportive relationships absence protective factors predicted prenatal perinatal postnatal complications likely affect health mental health youth reviews findings congruent theoretical positive feelings expectations broaden prenatal care adequate nutrition avoidance substance use turn positive activities help build social support relationships promote maternal infant health context protective cultural norms
despite good reason believe children foster care disproportionately exposed adverse childhood experiences relatively little research considers exposure among group vulnerable children article use data national survey childrens health nationally representative sample non children ages united states estimate association foster care placement exposure array adjusted logistic regression models find children placed foster care adopted foster care compared counterparts likely experience parental separation parental death parental parental abuse violence exposure household member mental illness household member substance abuse children also likely experience children across different thresholds socioeconomic disadvantage children households poverty line across different family structures children single mother families results advance understanding children foster care already vulnerable population disproportionately exposed exposure given link health implications childrens health wellbeing throughout life course elsevier ltd rights reserved
rare primary hepatic neoplasm recognized world health organization classification although cases reported date series includes extended follow early case reports novel cases clinical history histology reviewed cases tumor dna analyzed point mutations multiplex polymerase chain reaction copy number alterations array comparative genomic hybridization patients included females males presenting years age tumors ranging diameter tumors similar morphology mainly atypical epithelium embedded fibrous multiplex polymerase chain reaction identify mutations tumors tested three tumors tested array comparative genomic hybridization showed chromosomal copy number alterations including three patients underwent resection recurrence years follow one patient months resection two patients margin positive local recurrence years surgery patient distant metastasis distinct morphology multiple clonal cytogenetic alterations indicate lesions neoplastic typical benign neoplasms suggest tumors ability behave however clinical outcomes patients suggest neoplasms slowly progressive
epithelial cells oral mucosa responsible important functions like primary protection oral mucosa external building mechanical barrier microorganisms mechanical damage toxic material thermal regulation secretion different classes inflammatory mediators interesting tool cellular molecular biology research usually collected painful invasive process study propose alternative method collected non invasive method oral mucosa staining showed mainly two kinds epithelial cell population result five culture methods tested results revealed successfully cultured murine layer addition frozen without morphology changes loss viability findings suggest considered good cell source many purposes genetic studies diagnosis cell therapy
natural ventilation essential building technology long time significant role development architecture design natural ventilation replaced development air conditioning technology time however energy crisis greenhouse effect buildings inclined potential natural ventilation research use natural ventilation green building design divided three parts respectively additional structural measures space design double skin
region hemoglobin assembly protein genes genome previously found composed cloning region genomic dna identified four unique dna fragments different sizes sequencing cloned fragments revealed extreme heterogeneity characteristics internal eliminated sequence internal deletion sequences region missing sequences rich direct repeats existed boundaries southern blotting total genomic dna polymerase chain reaction pcr total genomic indicated exist dna fragments different sizes region likely heterogeneity found genome results variable removal region
study like highlight advantages disadvantages distance form education ways improve now learning expanding rapid rate quantitative terms qualitative parameters require detailed analysis objective merits problem areas try justify existing requirements opportunities tools propose ways improve order higher education institutions including management university compete educational market world educational space aim study improve instruments creation educational products distance education includes evaluation advantages disadvantages distance learning format university model existing distance education determination weak points implementation one way contact problems causes shot transfer knowledge computer monitors face face contact verbal nonverbal communication teacher student conditions development recent achievements technologies teaching media communications rapid development widespread use variety technical means primarily refer computer information technology satellite communication systems educational television mass connection information systems distribution learning software videos implement model distance education three stages analyzed methods used secondary education example analyzed teaching chemistry secondary school disabled children research first stage secondary school analysis applying distance form education second stage university together assessment problematic areas resulted creating effective model implemented model work great efficiency help eliminate many difficulties slow realization whole package instruments distance education
paper details design development evaluation affective system learning system detects responds emotional states learner research development active relatively new field many studies demonstrating promising results however often practical way apply findings real world settings described paper utilizes generic affective application model infer appropriately respond learners affective state approach brings several advantages notably potential direct support use retrospective addition affect sensing functionality existing learning software skin conductivity heart rate variability measurements used infer affective activation valence evaluation involved experiment effectiveness fully functional compared version conducted adult participants evaluation effectiveness system showed measurable improvements perceived learning obtained modest level software development
flood real time social data generated various social media applications sensors enabling researchers gain critical insights important social modeling analysis problems evolution social relationships analysis emergent social processes however current computational tools address challenge analyzing large dynamic social networks within strict time constraints available social data effectively utilized computational issues exacerbated network size range millions nodes need analytical tools work various computational architectures existing methodologies primarily deal dynamic relationships social networks simply computing results relying massive parallel distributed processing resources maintain time constraints previous work introduced overarching parallel distributed algorithm design framework called anywhere framework leverages inherent iterative property graph algorithms generate partial results whose quality increase processing time efficiently incorporates network changes paper focus centrality algorithm design dynamic social networks new relationships formed due edge using theoretical analysis empirical results demonstrate algorithm efficiently partial results reduces need computations
recent studies brain imaging analysis witnessed core roles machine learning techniques computer assisted intervention brain disease diagnosis various machine learning techniques sparse regression models proved effectiveness handling high dimensional data small number training samples especially medical problems deep learning methods making great successes state art performances various applications paper propose novel framework combines two conceptually different methods sparse regression deep learning alzheimers disease mild cognitive impairment diagnosis prognosis specifically first train multiple sparse regression models trained different values regularization control parameter thus multiple sparse regression models potentially select different feature subsets original feature set thereby different powers predict response values clinical label clinical scores work regarding response values sparse regression models target level representations build deep convolutional neural network clinical decision making thus call deep ensemble sparse regression network best knowledge first work combines sparse regression models deep neural network experiments cohort validated effectiveness proposed method achieving highest diagnostic accuracies three classification tasks also rigorously analyzed results compared previous studies cohort literature elsevier rights reserved
menopause rating scale measures quality life menopausal women compounds three dimensions assess somatic psychological menopausal related symptoms however validity scales vary according population characteristics date american indigenous population assess validity indigenous women menopause research done sample indigenous women postmenopausal women premenopausal years old mean age applied enrolled women cronbachs alpha applied original proposed dimensions dimensions results factor analysis maximum likelihood methods rotation applied analysis showed cronbachs alpha somatic dimension psychological dimension score greater postmenopausal compared premenopausal versus factor analysis showed two dimensions first dimension included items accounted variance second dimension included items explaining variance cronbachs alpha first dimension second dimension showed high internal consistency adequate validity factor analysis resulted two dimensions results evidence need better assess validity instruments different populations
sustainability trends buildings require new construction systems foster energy efficiency environmentally friendly buildings green roofs interesting construction systems provide aesthetic environmental benefits paper continues long term research order evaluate improve thermal behaviour sustainability extensive green roofs simultaneously research provides experimental data specific mediterranean climate conditions experiment consists evaluating energy consumption thermal behaviour three identical house like located spain difference roof construction system roof consists conventional flat roof insulation reference case two insulation layer replaced depth extensive green roof comparing recycled rubber drainage layer materials electrical energy consumption heat pump system measured part extensive green roof show less energy consumption respectively reference one warm periods whereas extensive green roof systems present higher energy consumption respectively compared reference heating periods elsevier ltd rights reserved
objective study applied human factors approach systems contribute understanding incidence severity pediatric head accelerations background previous research indicates low magnitude head accelerations common among participants study adds knowledge safety measuring aspects participants behavior linking head acceleration data method school aged students fitted global positioning system gps devices activity data collected sessions total hours head accelerations recorded units compared gps generated data results study found speeds attained normally exceed testing rating designed lower rates head accelerations compared earlier studies head accelerations occur generally threshold conclusion pediatric head accelerations rare generally low magnitude risk head acceleration male given recorded speeds first time participants increased targeting novice participants encourage education use protective equipment including warranted post event recall good indicator experienced head impact consideration given raising standard design speed testing protective devices reflect actual behaviors elsevier ltd society rights reserved
article presents example satellite propagation modeling applying radio channel transfer function analysis described experimentally verified scientific literature simulation satellite radio channel executed employing ray tracing uniform geometric theory diffraction based method assumed urban environment different derived results regarding channel transfer function analyzed via simulation wideband propagation measurement system fourier transform procedures concluded contrary ground cell radio system situations two ray models usually detailed calculation considered wideband satellite radio systems moreover shown conclusions derived path loss delay spread depend specific propagation scenario also building permittivity
objective savings agriculture governance empowerment health study evaluate impact large scale multi level economic food security intervention health outcomes hiv vulnerability rural study employed quasi experimental non equivalent control group design compare intervention participants people participating unrelated programs distinct similar geographical areas control conducted participant interviews baseline months hiv vulnerability related health outcomes food security economic vulnerability randomly selected households interviewed intervention control areas baseline months compared control group intervention led increased hiv testing hiv case finding decreased food insecurity increased nutritional diversity improved economic resilience effects sustained year period significant differences change found year study period surveys randomly selected households intervention control areas although general trends toward improvement study area intervention participants outcomes significantly better results indicate intervention improve economic food security hiv vulnerability increased testing case finding leveraging resources economic development deliver locally developed programs scientific funding conduct controlled evaluations potential accelerate scientific evidence base effects economic development programs health
production human papillomavirus type major protein undifferentiated cells negatively regulated several yet unidentified cis acting inhibitory rna elements among major element located within first nucleotides mrna northern blotting examined effect major element steady state level mrna transiently transcribed cells luciferase gene combined dna fragment encoding major element reported previously element regulated steady state level mrna efficient regulation achieved insertion element near end mrna resulting undetectable level mrna longer distance end mrna element weaker regulation half life mrna element similar normal mrna element near end removed splicing steady state level resultant mrna raised readily detectable level steady state level rna synthesized rna polymerase influenced presence element taken together suggested dna region encoding major inhibitory element transcription pre mrna degraded rna element mediated mechanism splicing step course mrna maturation
form emotional behaviour manifests adjustment physiological acts components globe eye thus systemic analysis adjustments different methods allows establishment connections level emotional state non verbal communication research object article based analysis vision correlation means make visual non verbal expression degree visual stimulation respectively illumination movement form sizes analysis methodology based data collection stimulation procedures visual system following physiological reactions subjects target group thus dynamic stimulation strategies visual system tracking physiological reactions subjects target group applied consequently dynamic stimulation strategies visual system applied order follow reactions visual behaviour results obtained analyzed methods processed image processing methods order highlight relations stimuli communication important aspect taken experimental researches analysis computerized methods also final results fast objective determination reporting coefficient stimulus behavioural answer authors published elsevier ltd
airway epithelial cells induce microenvironment modulating immune cells lung recently showed airway epithelial cells induces two marker genes alternative activation respiratory myeloid cells induction partially mediated glucocorticoids secreted airway epithelial cells study investigated regulation alternatively activated myeloid cells presence cytokines show expression boosted upon stimulation airway epithelial cell whereas expression regulated suggests crosstalk glucocorticoid signaling exists blocking protein synthesis indicated dexamethasone induced novo protein synthesis required interaction glucocorticoid signaling regarding regulation using reporter gene constructs demonstrate important regulatory region within promoter found upstream start translation bioinformatic analysis identified several glucocorticoid response elements region analysis identified overlapping functionally active glucocorticoid receptor stat binding sites supporting cooperative effect glucocorticoids regulation findings prove plasticity complexity alternatively activated myeloid cells importance local microenvironment believe regulation special importance pulmonary system since factors glucocorticoids play role airway diseases asthma elsevier gmbh rights reserved
suspension bridges flexible vibration sensitive structures exhibit complex multi modal vibration due usual vibration based methods face challenge used damage detection structures paper develops applies mode shape component specific damage index detect locate damage suspension bridge pre cables important suspension bridges large structures damage long service lives easily capability proposed vibration based demonstrated application detect locate single multiple damages varied locations severity cables suspension bridge outcome research enhance safety performance bridges play important role transport network elsevier ltd rights reserved
objective design alzheimers disease associated amyloid plaques beta tau protein brain investigated possible neuroprotective role dual inhibitor cox triple transgenic mice subjects mice months beginning study treatment animals received daily month saline solution methods water maze used assess learning memory histology performed evidence beta plaques neuronal loss inflammatory proteins determined western blot analysis results saline treated mice showed impairment spatial learning memory assessed months age increased expression inflammatory apoptotic molecules treatment mice reduced learning memory loss increased production phosphorylation level amyloid precursor protein app beta tau activation beta plaques neuronal loss compared saline treated animals conclusions pharmacological blockade cox able counteract progression targeting pathophysiological mechanisms downstream beta tau
therapeutic alliance perceived social support important predictors treatment response post traumatic stress disorder ptsd intranasal oxytocin administration enhance treatment response increasing sensitivity social reward thereby therapeutic alliance perceived social support first step investigate potential investigated whether intranasal oxytocin enhances neural sensitivity social reward ptsd patients male female police without ptsd included double blind randomized cross fmri study intranasal oxytocin placebo administration social incentive delay task conducted investigate neural responses social reward punishment anticipation feedback placebo ptsd patients showed reduced left anterior insula responses social rewards happy faces compared controls oxytocin administration increased left responses social reward ptsd patients ptsd patients longer differed controls placebo furthermore ptsd patients oxytocin increased responses social reward right putamen insula responses increasing putamen responses social reward oxytocin administration enhance sensitivity social support therapeutic alliance ptsd patients future studies needed investigate clinical effects oxytocin
arginine along mammalian oxytocin arginine known regulators social behaviors across vertebrate taxa however little known involvement paternal care measured effect via receptor antagonist paternal behaviors primarily paternal also measured effect receptor antagonist aggression dyadic two non reproductive fish assess specificity effect paternal behaviors individual differences levels paternal behaviors eggs proportion time consistent across cycles treatments administered receptor antagonist severely reduced paternal behaviors effect aggression whereas receptor antagonist increased paternal behaviors results support idea signaling crucial expression paternal behavior based previous study showing via antagonist decreases aggression dyadic hypothesize antagonist enhances paternal behavior indirectly reducing vigilance aggression thereby alleviating effort directed towards competing behaviors allowing increased expression paternal behaviors elsevier inc rights reserved
study designed examine intervene student behaviours promote inclusive participatory focus within sport education achieve increased understanding changes within student behaviours collaborative participatory action research methodology applied provide voice students agents change research progressed throughout entire school year cast two stages first season provided baseline respect issues equity inclusion followed intervention stage seasons soccer identified issues acted upon based upon issues action research cycles intervention focused different levels participation reconfiguration learning content peer teaching activities competition formats discussion exclusion gender discrimination emerging group dynamics within focus groups interviews promotion positive leadership behaviours student leadership conducted outside end year significant evidence inclusive membership accompanied development mutual trust among students shared contributions towards common inclusive goal close found game competence development trajectories participation sense membership power relations sharing knowledge investment dominant higher skilled students towards inclusive team goals sport education curriculum alone insufficient deeply rooted negative cultural influences community based sports influenced equity inclusion however planning implementing specific intervention used educational resources sport education possible promote inclusive learning environment
classical secret key generation model common randomness generated two terminals based observation correlated components common source keeping secret non legitimate observer assumed statistics source known participants paper secret key generation based compound source studied realization source statistic unknown protocol guarantee security reliability generated secret key simultaneously possible compound source single letter lower bound secret key capacity finite compound source derived function public communication rate constraint multi letter capacity formula computed finite compound source case public communication finally single letter capacity formula derived degraded compound source arbitrary possibly infinite set source states finite set marginal states
analytically study schrodinger type nonlinear evolution equations improved phi expansion method explicit solutions derived include optical bright solitons dark solitons singular solutions singular triangular periodic solution exact particular solutions containing four types hyperbolic function solution trigonometric function solution exponential solution rational solution obtained solutions comparing methods recently method developed searching exact travelling wave solutions nonlinear partial differential equations shown method help symbolic computation provide straightforward powerful mathematical tool solving problems nonlinear optic elsevier gmbh rights reserved
three dimensional modeling foundation graphic expression virtual reality digital landscape article explores key technologies methods applications three dimensional modeling virtual plant digital landscape manual modeling technology program generation technology software automatic generation technology measurement based reconstruction technology visual simulation landscape plant elements three dimensional modeling theories computer graphics main purpose provide three dimensional expression landscape design landscape planning theoretical guide promote sustainable development virtual plant modeling technology field landscape architecture
aim study assess whether oral liquid levothyroxine correct tablet levothyroxine induced calcium iron two levothyroxine nineteen adult hypothyroid patients tablet levothyroxine caused calcium iron supplements switched tablet liquid levothyroxine dose primary outcomes significantly lower mean serum thyroid stimulating hormone liquid compared tablet formulation significantly greater rate serum thyroid stimulating hormone less equal mean follow weeks tsh lower liquid levothyroxine compared tablet levothyroxine calcium group iron group thyroid stimulating hormone levels patients calcium group iron group frequent post switch compared pre switch thyroid stimulating hormone levels compared pattern held comparing first liquid levothyroxine thyroid stimulating hormone levels first tablet levothyroxine thyroid stimulating hormone levels corresponding rates thyroid stimulating hormone levels target liquid levothyroxine resistant calcium iron high rate thyroid stimulating hormone normalization already first check weeks avoid frequent adjustments levothyroxine doses assays thyroid stimulating hormone consequent financial savings
similarity differential equation beta beta considered differential equation appears study mixed convection boundary layer flows vertical surface embedded porous medium order prove existence solutions satisfying boundary conditions infinity use consider initial value problem consisting differential equation initial conditions give partial results show differences previous case
prosocial media effects short long term changes prosocial personality traits values emotions behavior caused media use attracted much less attention media violence research empirical examinations current theories prosocial media effects focused indirect effects prosocial media explain exposure results prosocial behavior however neglected types media effects biases field communication social cultural perspective used explain psychological antecedents consequences prosocial media effects origins ultimate functions processes media effects unknown intersection evolutionary theories media effects theories provides comprehensive explanation prosocial media effects using various evolutionary perspectives cooperation article types prosocial media effects selective indirect conditional suggesting dramatic prosocial media learning process considered comprehensive nature interactive view research agenda implications recent methodological advances highlighted
regardless service lifetime structure unwanted vibration occur due unknown sources excessive vibration lead feeling deterioration sensitive instruments industrial building determine nature mentioned vibration problems evaluation dynamic properties structure required recently researchers engineers spent lot effort control vibration behavior structures several methods developed field system identification alternative methods estimate structural modal parameters paper discusses evaluation dynamic properties existing platform structures unwanted vibration appears material pipe tends cause fatigue dynamic evaluation performed obtain natural frequency structures using model response measurement taken structure operational condition contribution mentioned models give satisfactory result compared fem model authors published elsevier ltd
aim authors randomized controlled study assess effect exercise nutrition education quality life early menopausal symptoms trial conducted east province iran period women allocated one four groups group block randomization interventions received three intervention groups nutrition education aerobic exercise exercise plus nutrition education control group receive intervention menopause symptom scales completed intervention mean score significantly lower control group exercise adjusted mean difference exercise plus nutrition groups end week nutrition exercise exercise plus nutrition groups end week also mean score significantly lower control group exercise exercise plus nutrition groups end week nutrition exercise exercise plus nutrition groups end week nutrition education aerobic exercise improve quality life
solar energy collection conversion great significance power transmission space solar power station influences overall system economically proposed omega concept original conceptual design non uniform energy distribution excessive energy density local areas cause decreases optical electric performance aiming point firstly paper evaluates optical performance omega concept via ray trace technique secondly geometry design photovoltaic cell array based curve carried obtain optimal optical performance available efficient response numerical examples achieve good collection efficiency suitable energy distribution finally modular construction main influence optical performance investigated moreover effect orbital motion tracking error analyzed provide reference realization omega
architectural heterogeneity proven effective design paradigm cope ever increasing demand computational power within tight energy virtually every computing domain programmable currently widely used high performance computing systems also embedded devices operate control general purpose cpu host processor clearly powerful hardware architectures paired sophisticated complex software ecosystems composed operating systems programming models plus associated runtime engines increasingly complex user applications related libraries system modeling always played key role early architectural exploration software development real hardware available necessity efficiently coping huge design space provided described heterogeneous systems chip calls advanced full system simulation methodologies tools capable assessing functional properties target system article describe simulation tool targeting full system simulation massively parallel heterogeneous also describe successfully adopted several research projects
virus mutant deletions genes glycoprotein glycoprotein constructed evaluated candidate vaccine strain protective virulent strain challenge pigs transfer plasmid constructed transfected genome cells generate recombinant mutant virus recombinant virus confirmed southern blotting indirect immunofluorescence assay animal experiments immunogenicity tested enzyme linked immunosorbent assay elisa neutralizing assay elicited significant humoral immune responses immunization protected pigs lethal challenge virulent strain results suggested recombinant considered potential candidate vaccine
objectives hypothesis number trained available insufficient supply current projected health care needs goal study assess available databases present accurate data current workforce examine methods prediction future health care needs explore potential issues forecasting methods policy implementation based predictions study design retrospective analysis research databases public use files claims data methods total number current practices united states using databases american academy head neck surgery american medical association american board american college surgeons association american medical colleges national center health statistics department health human services identified surgeons classified surgical groups using combination primary secondary self reported american board medical data gathered cross referenced rule assess total practicing data analyzed included type practice academic versus private general versus specialty demographics urban versus rural patient age reason visit referral new established surgical follow reason visit diagnosis type results analysis resources estimates total number practicing united states approximately fully trained practicing physicians training residents others based data workforce projections place fully trained practicing workforce unless changes training occur physicians resource committee performed extensive analysis data multiple sources identified practicing training estimated current attrition rate approximately per year percentage distribution office visits patient age found years old reason visit new chronic chronic exacerbation pre follow top diagnoses consisted media chronic impacted mix consisted private insurance medicare medicaid childrens health insurance program conclusions despite past findings predictions practicing united states data resources places total fully trained practicing workforce impact future predictions resource utilization analysis even correction considered available trained required serve health care needs population still insufficient impact aging population estimated million newly insured citizens patient protection affordable care act also unprecedented variables considered analysis differences physician productivity geographic population density model formation current workforce utilization needed predict future public health needs
scarcity fossil fuels affecting efficiency established modes transport within transportation industry efforts made develop innovative modes transport adopted economic environmental friendly operating systems solid material instance packed rectangular containers commonly known transported different concentrations effectively using fluid energy pipelines economical efficient design systems local flow characteristics global performance parameters need carefully investigated published literature severely limited establishing effects local flow features system characteristics hydraulic capsule pipelines present study focuses using validated computational fluid dynamics cfd tool numerically simulate solid liquid mixture flow applications including discrete phase modelling employed calculate velocity rectangular numerical predictions used develop novel semi empirical prediction models pressure drop embedded robust user friendly pipeline optimisation methodology based least cost principle elsevier ltd rights reserved
suicide important public health problem adolescents essential increase knowledge concerning etiology suicide among adolescent students therefore study designed examine associations depression suicidal behavior examine moderator depression suicidal behavior among adolescent students participants completed measures depression daily spiritual experience suicidal behavior structural equation modeling indicated adolescent students high depression also high less suicidal behavior others findings reinforce importance protective factor depression suicidal behavior among adolescent students
layer upper section member formation district depression developed sedimentation several periods lacks stable layers sophisticated classification sedimentation periods proportion period long difficult task addressing problem paper attempts introduce theory climatic cycles driven periods basis characteristics sedimentation turbidity current region study studying conditions formation layer factors control formation layer differentiate cycle interface correlation formation period analysis conducted sedimentation layer region study determine cycle region primarily controlled cycle calculate thicknesses respectively theory primary tool used analysis conjunction analysis stratum classified four grade sequences grade sequences information dominant cycle frequency used wave filtering logs determine significant wave log data curve compare cycle characteristics standard cycle classify compare sedimentation periods layers detail
harnessing benefits cloud computing demands potential user adequate access trustworthy cloud services locating resources services heterogeneous network cloud environment tedious task cloud computing form distributed system complex aggregation computing resources different domains different administrative policies immense benefits enhance mode computing discovering cloud services complicated varied level quality service offered different providers hence monolithic approach cloud service discovery effectively support cloud environment work proposed approach discovering trustworthy cloud services use system achieving intelligent cloud service discovery simulation experiments carried results showed extending multi agents system approach integrating trust process cloud service discovery improves quality service terms response time scalability comparative analysis multi agents system approach cloud service discovery monolithic approach showed highly efficient highly flexible trustworthy cloud service discovery
common high nutritional medical value although number genes involved fruit species identified little known process differentiation study serial analysis gene expression applied determine gene expression profiles effort advance understanding molecular basis fruit body development total tags extracted unique tags matched house expressed sequence tag est database difference expression profiles suggests specific set genes required fruit body development transition different expressed abundantly fewer structural genes expressed transcription translation became active different genes became involved intracellular trafficking stress responses expressed findings advance understanding fruit body development used cdna microarray hybridization northern blotting verify results found highly efficient performance transcriptome analysis knowledge first study british society published elsevier ltd rights reserved
manual handling municipal solid waste serious concern owing emerging occupational risks considering health risks municipal solid waste workers involved street waste collection waste processing assessed india using interview schedule study tool result shows waste worker profession mainly dominated males except lower literacy rate age distribution shows waste collectors age daily income waste workers ranges observed waste collectors street use type protective owing attitude results various types injuries major occupational health issues reported various categories waste workers respiratory disorders injuries allergies prevalence respectively waste workers vulnerable occupational health hazards hence need formulation new laws policies
matrix computation considered core many machine learning graph algorithm workloads traditional single node age numerical analysis platforms like matlab provide matrix programming model data increasingly scaled big data era increasing demand seamlessly integrate large scale matrix computation distributed data parallel computing systems therefore variety matrix computation libraries implemented distributed computing platforms mpi hadoop spark however specific matrix based algorithm quite different performance different platforms challenging data scientists specify platform combination platforms given algorithm workflow achieve best performance solve problem paper put forward time cost based scheduling framework automatically specify best platforms matrix operations schedule execution workflow implemented system prototype using user language mpi spark computing platforms experimental results show time cost based model good accuracy less error rate average moreover scheduling framework built achieves efficient performance applications
paper aimed investigate influence online coding courses logical reasoning ability towards fifth sixth students used online programming courses three months standard progressive matrices testing understand change students logical reasoning ability experiment based technology acceptance model researcher learning attitude questionnaire explore attitude students towards courses factors influencing students learning online courses
background cognitive impairment common type diabetes mellitus strong association type diabetes alzheimers disease however know type diabetes patients biomarkers predict cognitive decline left ventricular hypertrophy potentially marker highly prevalent type diabetes strong independent predictor cardiovascular events date studies investigated association cognitive decline type diabetes diabetes dementia study designed establish whether patients type diabetes increased rates brain atrophy cognitive decline methods study single centre observational longitudinal case control study follow adult patients aged years type diabetes case without control assess change cardiovascular risk brain imaging neuropsychological testing two time points baseline months months primary outcome brain volume change months primary outcome presence cognitive decline months secondary outcome change left ventricular mass associated brain atrophy cognitive decline months discussion study test hypothesis patients type diabetes exhibit greater brain atrophy without understanding whether contributes cognitive decline patients allow identify patients particular risk
internet things paradigm everyday objects equipped identifying sensing networking processing capabilities allow communicate one another devices services internet accomplish objective ultimately iot devices ubiquitous context aware enable ambient intelligence article reports current state research internet things examining literature identifying current trends describing challenges threaten iot diffusion presenting open research questions future directions comprehensive reference list assist researchers
paper deals design evaluation quadratic optimal control method based bilinear state space modelling approach order improve asymptotic stability voltage source converter steady state mathematical model converter developed around operating point converters increasingly popular development connection multi terminal grid main role studied converter transmission system regulate bus voltage intention paper propose rigorous control method based optimization algorithms finally proposed control method evaluated using matlab simulink
describe new reverse simulation approach analog mixed signal circuit test generation digital test generation analog circuit signal flow graph reverse simulate good bad machine outputs obtain test waveforms component given circuit output specified functional test needs designer inverted graph allows justify analog outputs analog input mixed signal circuits tested using approach present test generation results two mixed signal circuits four analog circuits one multiple input multiple output circuit analog method generate tests second order analog circuits certain non linear circuits handled existing methods lack fault model method proposed method also defines necessary circuit structural components order keep output circuit signal within envelope specified designer avoids problem analog circuit component reduces cost prove parametric fault tests also detect catastrophic faults unlike prior methods structural rather functional analog test generation method
objective authors compared cognitive behavioral therapy cbt therapy treatment bulimia nervosa female adolescents method randomized controlled trial female adolescents partial according dsm received mean sessions disorder oriented cbt trained psychologists blinded treatment condition administered outcome measures baseline treatment end treatment months treatment primary outcome rate remission defined lack dsm diagnosis partial end therapy several secondary outcome measures evaluated results remission rates cbt respectively significant differences odds ratio within group effect sizes cbt significant improvements secondary outcome measures found cbt improvements remained stable month follow groups small group effect sizes binge eating favor cbt eating concern favor conclusion cbt effective promoting recovery female adolescents rates remission therapies similar studies evaluating cbt trial identified differences small effects binge eating eating concern
study aimed assess using tree based models impact different dimensions religion risk factors suicide attempts republic iran three hundred patients attempted suicide age sex matched patient types disease referred hospital recruited study following convenience sampling assessed university religion index tree based model constructed using index homogeneity criterion complementary discrimination analysis also applied variables contributing construction tree stressful life events mental disorder family support religious belief strong religious belief protective factor low number stressful life events high mental disorder score formed two groups attempted suicide moreover high number stressful life events strong family support strong problem solving skills low mental disorder score less likely attempt suicide significance four variables problem coping skills support neuroticism revealed discrimination analysis religious beliefs seem independent factor predict risk suicidal behavior based decision tree religious beliefs among people high number stressful life events factor subjects need family support problem solving skills
recent research revealed cognitive processes influenced bodily cues cues found elicit disparate effects cognition instance weight inhibit problem solving performance shown increase judgments regarding recall probability judgments learning memory tasks investigated effects physical effort learning conducting two studies varied whether learned participants entered word completed recall test experiment revealed exerting physical effort wearing led higher easy without notable effect difficult participants reached higher recall scores therefore physical effort act form desirable difficulty learning experiment influence physical effort learning disappeared difficult learned implying high cognitive load diminish bodily effects findings suggest physical effort mainly influences superficial modes thought raise concerning explanatory power centered accounts higher level cognition
background innate helper type immune responses mediated interleukin stromal shown play important role pulmonary fibrosis animal models however clinical implications remain poorly understood methods concentrations measured bronchoalveolar lavage fluids obtained normal controls patients idiopathic pulmonary fibrosis ipf non specific interstitial pneumonia hypersensitivity results levels significantly higher patients ipf relative respectively respectively respectively groups respectively however levels significantly different ipf group receiver operating characteristic curves levels revealed clear differences ipf groups auc respectively ipf lung disease groups auc respectively cut values shown differentiate ipf groups accuracy cut values possessed accuracy differentiating among ipf interstitial lung disease groups conclusions innate immune responses associated development ipf furthermore levels fluids useful differentiating ipf chronic interstitial lung diseases
parental health exposures affect lifetime health outcomes offspring independently inherited genotypes epigenetic effects occur broad range environmental stressors including defects parental metabolism although maternal metabolic effects documented recently established also independent paternal contribution long term metabolic health paternal induce metabolic phenotypes immediate offspring cases induced phenotype affect multiple generations implying inheritance acquired trait male lineage transmission metabolic disease risk cases heritable factor carried sperm sperm based transmission provides system heritable epigenetic factors influencing metabolism detailed animal models paternal programming already provided significant insights review evidence paternal programming metabolism humans animal models available evidence potential underlying mechanisms programming paternal metabolism observed multiple species across animal suggesting phenomenon unique evolutionary significance
monitoring deformation super structures different environmental conditions important challenging issue assessing safety structures paper presents new method calculating structural deformation using real time strain data easily measured different sections assuming structural deformation bending beam type deformation structure associated longitudinal strain virtual work theory used calculate horizontal displacement tilt angle building basis strain data different heights structure proposed method applied tower previously known new tower long term structural health monitoring system including strain installed different heights displacements structure top normal conditions calculated using real time monitoring strain data calculated deformations show good agreement measurements using global positioning system gps temperature induced maximum daily movement similar value induced motion moreover displacement mode super structure also calculated shows bending type error analysis demonstrates calculated displacements higher accuracy gps measured counterparts calculated similar accuracy measured elsevier ltd rights reserved
article details preliminary findings laid bare collaborative research project university trust explore multidimensional relationship respondents identified formed material together role within gay male consider interview respondents understood findings reveal consistent general discussions gay specific discussions representations utilising work ambivalent develop critical reading order identify methods handled respondents
genus comprises human skin involved superficial infections also isolated deeper infections particularly certain risk patients neonates patients nutrition little known epidemiology virulence due mainly difficulty distinguishing species currently species identification based morphological biochemical characteristics molecular biology techniques identify species certainty time consuming expensive aim study develop evaluate matrix assisted laser desorption ionization time flight maldi tof database identifying species mass spectrometry eighty five isolates patients three french university hospitals investigated strain identified internal transcribed sequencing forty five strains six species allowed creation maldi tof database forty strains used test database strains identified database log scores according manufacturers criteria repeatability reproducibility tests showed coefficient variation log score values conclusion new database allows easy fast reliable identification species implementation database contribute better rapid identification species helpful gaining better understanding epidemiology
data start play significant role power system operation dynamic study data processing data analysis capability critical wide area measurement systems frequency monitoring network network data hundreds frequency disturbance distribution level previous data center limited data storage capability computation power targeting scalability robustness distributed data analytics platform proposed paper process large volume high velocity dataset variety real time non data analytics applications platform computation load shared balance multiple nodes analytics cluster big data analytics tools apache spark adopted manage large volume data boost data processing speed future data analytics applications easily developed system simple configuration
developed array transducer integrated transmit receive application specific integrated circuit asic real time echocardiography ice applications asic transducer design optimized high voltage transmit low voltage time gain control digital control circuits transducer element fit within area element transducer assembly deployed diameter catheter integrated ultrasound imaging system evaluated three preclinical studies image quality imaging modes comparable commercial ice field view least degrees degrees vol sufficient visualize cardiac anatomy diagnostic therapy ice significantly reduce ray use dose electrophysiology ablation procedures ice able replace echocardiography associated risks costs general anesthesia guidance structural heart procedures
study provides evaluation group schema therapy inpatient treatment patients personality pathology respond previous psychotherapeutic interventions forty two patients assessed pre posttreatment patients evaluated follow months later results showed dropout rate dropped differ completed treatment regard demographic clinical variables exception dropped showed lower prevalence mood disorders furthermore intention treat analyses showed significant improvement maladaptive schemas schema modes maladaptive coping styles mental psychological distress treatment improvements maintained follow hand significant change experienced parenting style self reported patients changes schemas schema modes measured pre posttreatment predictive general psychological distress follow overall preliminary findings suggest positive treatment results obtained group based inpatient treatment patients respond previous psychotherapeutic interventions moreover findings comparable treatment results patients without treatment history
aiming difficult problem high precision frequency stabilization semiconductor laser diode laser frequency control realized design semiconductor drive system relationship emission frequency temperature derived theoretically temperature corresponding stable frequency obtained according desired temperature stability temperature control system designed composed temperature setting circuit temperature gathering circuit temperature display circuit analog pid control circuit semiconductor control circuit module sampling technology voltage platinum resistance acquired converted temperature display liquid crystal display pid analog control circuit controls speed stability precision temperature control constant current source circuit designed provide reference voltage voltage stabilizing chip buffered operational amplifier connected drive semiconductor laser provide stable current semiconductor laser circuit board finished experimental justified experimental results show design temperature control system achieve goal temperature monitoring meanwhile temperature stabilized degrees degrees output voltage constant current source current
several studies sustainable technologies built environment green roofs green walls etc carried many focus technical performance technologies nonetheless also becomes necessary examine public technologies understanding clearly important support widespread use specifically perception incorporated product design increase peoples acceptance contribution paper twofold first presents results survey examining perception people small city southern region brazil regarding three sustainable technologies green roofs green walls dry second proposes set preliminary design guidelines improve acceptance sustainable technologies based peoples perception make technology look good make visible benefits provided technology design technology avoid concerns american society civil engineers
fifty years research effect violence children leads conclusion viewing media violence related increases aggressive attitudes values behaviors changes aggression short term long term changes mediated neurological changes young effects media violence real strong confirmed careful reviews research evidence various scientific professional organizations concerned childrens mental health development
order provide additional information risk assessment main objectives elucidate interactions different human liver enzymes identify semi quantify metabolites vitro identify human cyp enzymes responsible metabolism mean inhibitory concentrations respectively reactions formation human liver microsomes predominant metabolites two derivatives one derivatives basis previous rat studies alanine methyl ester alanine methyl ester amounts alanine higher microsomes carcinogenic detected among nine major human one responsible major isoform responsible formation elsevier rights reserved
failure detection localization capabilities sensors based graphene tested results shown strain sensing capability reversible presenting hysteresis demonstrated cycles elucidated stationary load applied normalized electrical resistance increases remains mainly constant load maintained load completely removed structure initial electrical resistance reinforced sensor additionally developed epoxy sensors demonstrated detect locate damage sample due electrical network failure occurs differentiated changes due strain caused increase elsevier ltd rights reserved
field observations erosion geosynthetic clay liner covered black reported composite liner left exposed without protective soil cover much longer recommended manufacturer new light transmission technique developed investigate erosion features field presented classification system developed describe type erosion features observed results five field investigations university environmental liner test site reported quantify onset progression severity erosion one particular geotextile needle exposure periods weeks years first significant erosion feature type loss observed months exposure erosion features type loss wider observed months exposure findings highlight need follow manufacturers recommendations timely covering composite liner soil following liner installation
paper employ extended variable coefficient homogeneous balance method backlund transformation simplified method derive auto backlund transformation multiple soliton solutions multiple singular soliton solutions dimensional potential equation also obtain variety traveling wave solutions soliton type solutions rational solutions distinct physical structures
chaos complex behavioural pattern associated nonlinear systems association analytical complexity generating system thought minimal experiments show necessarily true increase analytical complexity newer classes dynamical behaviour seen call new classes emergent system study remains far physics represents concerned apply methods increase intrinsically degrees freedom propose four techniques latter complex splitting signal flow graph products interpolation extrapolation interesting new behavioural patterns emerge experimentally report time parameters new route chaos named gibbs
many attempts made measure various aspects parenting within variety theoretical frameworks remains much work development reliable valid measures common themes across papers included special issue measurement parenting discussed parenting constructs vital part work prevention scientists support needed researchers engage measurement development bright spots regard today common science behavior change program sponsored national institutes health
synthetic aperture radar sar image segmentation investigated feature extraction algorithm design characterized two aspects multiple heterogeneous features extracted describe sar images corresponding similarity measures developed independently avoid mutual influences different features order enhance final similarity objects method called fuzzy clustering based independent subspace iterative optimization proposed integrates multiple features objective function iteratively optimized feature subspace obtain final segmentation results strategy protect distribution structures data points feature subspace realizes effective way integrate multiple features different properties order improve computation speed accuracy feature description design region merging algorithm use many kinds information quickly regions inside true segments experiments synthetic real sar images show proposed method effective robust obtain good segmentation results short running time authors published spie creative attribution license
vegetables including characterized high number valuable metabolites act effectively cancer prevention already revealed several studies work investigates effect type container low density polyethylene packages oriented packages selected quality parameters frozen vegetable subjected months storage every stage experiment material examined terms dry matter vitamin total content antioxidant activity statistical analysis proved type container considerable effect levels aforementioned constituents antioxidant activity stored vegetables
study present modular like robot utilizes voice coils new paradigm soft robot actuation drive electronics incorporated actuators providing significant improvement self compared existing soft robot actuation modes hydraulics body plan robot inspired consists three dimensional printed voice coil actuators connected flexible membranes electromagnetic actuator neighbor extend membrane segment sequence actuated results inspired motion find minimum three segments required locomotion due modular design robots length quickly easily assembled addition actuation voice coils provide audio input output capabilities demonstrate transmission data segments high frequency carrier waves using similar mechanism note passing power coupled coils neighboring external power also possible voice coils convenient multifunctional alternative existing soft robot actuators self contained nature ability communicate ideal modular robotics additional functionality sound input output power transfer become increasingly useful soft robots begin transition early proof concept systems toward fully functional highly integrated robotic systems
acetyl hydroxy ethyl cysteine iso identified human metabolite study report excretion iso human urine single oral administration labelled one healthy male volunteer ingested dose equivalent dose period urine collected iso levels analysed excretion iso begins five hours application rises maximum concentration max quantified urine excreted max excretion pattern parallel major oxidative metabolite acetyl hydroxy ethyl cysteine total recovery iso applied dose together acetyl cysteine applied dose eliminated acids elimination kinetics three acids compared show dietary doses cause overload detoxification via lead formation carcinogenic human body
driven accelerator designed china institute atomic energy beijing radio ion beam facility project system designed use two power sources drive two half wavelength respectively two accelerating electrodes kept separately inside accelerating voltages maintained phase efforts control analog digital hybrid system developed achieve cavity tuning control voltage amplitude phase stabilization etc analog subsystems designs focused signal conversion tuning control voltage regulation digital system provides signal source cavity phases maintains finite state machine digital parts combine analog functions provide control brief system hardware introduction given paper followed review several major characteristics digital control system also introduced optimization process done changing digital parts elsevier rights reserved
consumers want ensure enterprise data stored cloud data objects access patterns revealed including cloud provider public cloud environment created detailed ontology describing cloud storage models role based access controls place manage risk developed algorithm store cloud data using data structure defined paper also implemented application allows users manage cloud data validating storing data structure application uses role based access control model collection based document management store retrieve data efficiently cloud consumers use system define policies storing data manage storage cloud platforms even unfamiliar underlying technology concepts data structures
computerized obstructive sleep apnea detection necessary speed sleep apnea diagnosis research assisting medical professionals moreover development device monitor sleep apnea low power portable requires reliable successful sleep apnea detection scheme article problem automated sleep apnea detection using lead ecg signals addressed first segments ecg signals decomposed using data adaptive signal decomposition scheme namely tunable factor wavelet transform three statistical features extracted sub bands train test matrices formed afterwards matrices fed classifier identify non ecg signal segments work new machine learning algorithm namely random sampling boosting implemented perform classification first time along employed automatic sleep apnea detection knowledge overall algorithmic performance method various values parameters optimal values parameters investigated determined efficacy appropriateness demonstrated opposed commonly used classification models algorithmic performance sleep apnea identification scheme also evaluated existing detection algorithms literature experimental outcomes manifest sleep apnea identification scheme performs better existing works sensitivity specificity accuracy anticipated owing use one channel ecg signal proposed method ideal device implementation eliminate clinicians analyzing large bulk data manually sleep apnea diagnosis
paper reviews efficacy safety systemic absorption estradiol low dose beta estradiol vaginal capsule designed treat vaginal atrophy postmenopausal women improved user experience phase phase studies significantly improved proportions vaginal superficial cells vaginal phase study decreased severity vaginal vaginal irritation two randomized phase trials estradiol max auc significantly lower doses approved vaginal estradiol tablet trial showed estradiol auc different placebo days associated higher auc versus placebo days levels remained within postmenopausal range estradiol day values three doses different placebo demonstrating estradiol accumulation doses tolerated acceptable safety profile reviewed studies local vaginal efficacy significantly better placebo overall safety profile similar placebo negligible low systemic estradiol absorption observed whether given approved alternative option women symptomatic without increasing mean systemic estradiol absorption postmenopausal levels authors published elsevier ireland ltd
introduction hospital common expensive key target medicare value based program validated risk assessment tools hospital score index developed identify patients high risk hospital targeted interventions aimed reducing rate study aims evaluate utility hospital score index predicting hospital within days moderate sized university affiliated hospital united states materials methods adult medical patients underwent one icd defined procedures discharged service medical center october march studied retrospectively determine hospital score index significant predictors hospital within days results study period discharges recorded service analysis includes data discharges patients died hospital stay transferred another hospital left medical advice excluded patients hospital within days receiver operating characteristic evaluation hospital score patient population shows statistic indicating good discrimination hospital score hospital score setting indicating good overall performance fit test shows chi value value receiver operating characteristic evaluation index patient population shows statistic indicating poor discrimination hospital score index setting indicating good overall performance fit test shows chi value value discussion single center retrospective study indicates hospital score superior ability compared index predictor hospital within days medium sized university affiliated teaching hospital conclusions internationally validated hospital score superior index moderate sized community hospitals identify patients high risk hospital within days
geotextiles commonly used globally making control material selection influence geotextiles properties important research topic study aims explore effects ratio high strength polyethylene fiber fiber hybrid geotextiles first stage polyethylene pet fiber combined make pet hybrid geotextile tested porosity water permeability determining optimum pet ratio second stage content pet fibers fibers fibers mixed various ratios form pet hybrid geotextiles experimental results show increase content fibers porosity water permeability pet hybrid geotextile decrease
true poorly known member family distribution northern hemisphere thought restricted temperate warm temperate waters north atlantic records southern hemisphere suggest wider distribution extending waters atlantic coast brazil south africa australia sea coast new zealand paper reports first molecular confirmation occurrence southern limit distribution recorded northeast atlantic islands describes new species using evidence molecular species confirmation iii contributes sparse worldwide database live including first underwater video recording species close images species identification confirmed two cases using mitochondrial dna control region cytochrome gene markers male stranded islands november male found floating dead near july stranded islands clearly white area head extending tip cover contrasts previous descriptions species rare variability north atlantic confirmed live data recording several observations species deep relatively coastal waters islands suggests unique locations study behaviour
similarity search important fundamental problem thus widely used various fields computer science including multimedia computer vision database information retrieval etc recently since behavior often leads abnormal situations attacks analysis increasing attention research communities paper present discovery system adopting efficient similarity search surveillance videos know existing systems analysis mainly focus detect identify behavior tracking techniques however difficulties tracking based methods known analysis results heavily influenced moreover tracking based methods need track human appearance continuously therefore existing methods readily applied real world surveillance cameras due appearance criminal solve problem tracking method instead propose efficiently discover based frequent appearance patterns multiple surveillance videos propose novel data structure indexes data using similarity value returned corresponding function face matching adopted perform efficient similarity search realize discovery conducted extensive experiments synthetic real surveillance videos evaluate efficiency efficacy approach experimental results show system find candidates correctly outperforms existing method times terms runtime
directly perturbed healthy subjects cortical areas generate electrical oscillations beta range schizophrenia major depressive disorder bipolar disorder oscillations markedly reduced terms amplitude frequency however still remains unclear whether abnormalities modulated time still observed treatment employed transcranial magnetic stimulation combined eeg assess frontal oscillatory activity eighteen patients antidepressant treatments sleep deprivation light therapy relative nine healthy controls order detect dominant frequencies event related spectral perturbations computed eeg session participants using wavelet decomposition natural frequency cortical circuit calculated frequency value largest power across post stimulus time interval severity depression markedly decreased treatment patients achieving response nine patients achieving remission eeg resulted significant activation beta gamma band response healthy controls patients main frequencies eeg responses significantly change treatment always significantly lower controls comparable patients achieving remission responding treatment results suggest reduction natural frequencies trait marker independent clinical status patients present findings light neurobiological underpinning severe psychiatric disorders demonstrate eeg represents unique tool develop biomarkers psychiatry elsevier masson sas rights reserved
drug exhibiting symptomatic effects parkinsons disease recently reported exert rodent models one proposed neuroprotective mechanisms involves increased protein expression specific subunit glutamate system inducing glutathione gsh synthesis investigated outcome treatment mouse model based proteasome inhibition whether observed effects mediated system proteasome inhibitor administered male mice receiving repeated intraperitoneal injections either vehicle drug administration initiated three days prior injection maintained six days post surgery one week lesion mice assessed investigated terms neurodegeneration molecular changes level basal ganglia including expression levels reduced loss dopaminergic neurons following injection degree sensorimotor impairment failed however modulate expression basal ganglia mice separate set experiments impact treatment system investigated control conditions vivo vitro similarly influence glutathione levels naive male mice alter system activity glutathione content vitro taken together results demonstrate treatment provides behavioral improvement mouse model based proteasome inhibition via system independent mechanisms elsevier inc rights reserved
construction site induced water pollution negatively affect environment economic social people underlying problem initiated study current management approach mitigation based site water pollution practices construction planning consequently production environmental variable study improve current practice integrating site water pollution practices construction planning prevention based concepts order simultaneously address production environmental aspects construction exploratory nature study warrant use research methods involve systematic review integrative literature review also verification semi structured interview industry players research findings suggest distinctive elements site water pollution preventive practices construction planning schedule method site layout integrated applied simultaneously construction schedule found prominent element established integration initial target practical implementation framework study work acts bridge practical industry aspects preventing site water pollution linkage construction planning elements consequently findings study gap knowledge sectors enable concurrent management production environmental dimensions construction elsevier ltd rights reserved
microwave processed characterized dielectric properties function temperature frequency low dielectric loss achieved mhz frequency grain grain boundary contribution towards conductivity presented basis plots resistances evaluated semi circular equivalent electrical circuits approximate values presented better insight high dielectric constant possibility good electromagnetic absorption material shift transport phenomenon suggested band like rise addition electromagnetic interference properties studied results show interference efficiency achieved compositions ranging ghz suitable application elsevier ltd rights reserved
protein protein interaction vital process drives many important physiological processes cell also implicated several diseases though protein protein interaction network quite complex understanding interacting partners using silico molecular biology techniques provide better insights targeting interactions targeting protein protein interaction small molecules challenging task issues nevertheless several studies kinetics thermodynamic properties protein protein interactions contributed toward better understanding affinity complexes recent studies hot spots interface residues opened new avenues drug discovery process approach used design hot spot based modulators targeting protein protein interaction objective interactions authors production hosting elsevier behalf university open access article http creativecommonsorg licenses
product portfolio diversity prominent customers critical manufacturers manufacturers perspective diversity maintained level engineering costs exceed acquired advantages increased market share therefore paper consider problem product portfolio planning simultaneously market share minimise manufacturing engineering costs since problem belongs hard class problems exact algorithms rendering optimal solution therefore used metaheuristic based simulated annealing deal problem proposed algorithm consists two parts random search predetermined rule generate next possible product portfolio order robust algorithm calibrated different levels problems parameters using method method best levels different parameters conducting least possible experiments evaluate performance proposed algorithm compared strong algorithm genetic algorithm used comparison basis research obtained computational results clearly demonstrate efficiency effectiveness proposed algorithm
muscle activity growth considerably important mandible quality morphology reducing dietary loading directly influences development metabolic activity mandibular cartilage however overall investigation changes protein composition fully described literature study protein expression putative signaling vivo evaluated structural changes differentially expressed proteins induced reducing functional loading rat developmental stages tag relative absolute quantitation based nano high performance liquid chromatography hplc matrix assisted laser desorption ionization time flight time flight maldi tof tof technologies used global protein profiling pathways functional categories analyzed consequently histological resistant acid phosphatase staining indicated altered histological structure cartilage increased bone remodeling activity hard diet group total differentially expressed proteins identified analysis revealed significant number proteins involved metabolic process cellular process biological regulation localization developmental process response stimulus pathway analysis also suggested proteins participated various signaling pathways including calcium signaling pathway gap junction signaling pathway mitogen activated protein kinase signaling pathway collagen types validated immunohistochemical staining western blot analysis taken together present study provides insight molecular mechanism regulating growth remodeling induced reducing dietary loading protein level
introduction prior studies reported association sexual dysfunction pelvic floor dysfunction without defining aim investigate predictors sexual function women including pelvic organ stress urinary incontinence overactive bladder fecal incontinence methods retrospective cross sectional study included women mean age years postmenopausal referred subjects underwent standardized history examination including demographics assessment pelvic floor function sexual function using validated quality life instruments physical examination included body mass index pelvic organ quantification measurements pelvic muscle strength scale proportional odds regression analysis tested patient characteristics determinants sexual dysfunction predictors sexual function main outcome measures pelvic floor distress inventory pelvic floor impact questionnaire assess short personal experiences questionnaire assess sexual function results prevalence included pelvic organ stress urinary incontinence overactive bladder fecal incontinence subjects sexual partner reported recent sexual intercourse participants reported low level sexual desire sexual enjoyment moderate levels sexual arousal stratified sexual enjoyment sex group lower scores reflecting less quality life burden pelvic organ fecal incontinence associated sex however adjusted determinants sexual dysfunction aging atrophy partner issues associations disappeared conclusion women also large burden sexual dysfunction although appears mediated factors unique copyright international society sexual medicine published elsevier inc rights reserved
lack existing studies fatigue testing materials study analyzes principle generating reflective cracks using three types composite specimens direct asphalt mixture layer nonwoven geotextile layer material layer study proposes method laboratory fatigue testing observing reflective cracks specimens used bending fatigue test centric load shear fatigue test load test results analyzed regression analyses showed material layer much better crack resistance direct asphalt mixture layer nonwoven geotextiles layer material layer absorb bending shear stresses near cracks efficiently delay generation expansion reflective cracks study used reference make reasonable selection material rigid flexible composite american society civil engineers
purpose study investigate model described explains relationships among search meaning life presence meaning life vacuum frustration power sample college students large mid atlantic university completed paper pencil instruments variables structural equation modeling used test compare four competing alternative models relationships among aforementioned constructs two models exhibited excellent fit one model good fit fourth model poor fit two best models one treated power outcomes treated causes limitations suggestions future research implications clinical practice also discussed
introduction emerging viral infections represent major concern human veterinary public health urgent need development broad spectrum covered recent strategy antiviral research based identification molecules targeting host functions required infection multiple viruses number fda approved drugs used treat several human diseases cationic drugs ability accumulate inside cells affecting several structures functions viruses infection review summarized chemical properties effects cells reported main fda approved identified far potential drug commentary although concerns regarding efficacy possible side effects label use seem represent promising starting point development broad spectrum antiviral strategies knowledge mechanism action required improve antiviral activity reduce risk side effects
race gender categories although long presumed perceived independently social perception due part natural confounding phenotypic cues predicted target gender affect race consistent hypothesis feminine faces white masculine faces asian black ambiguous targets study targets study real facial photographs study efficiency judgments varied concomitantly white rendered rapidly feminine relative masculine faces opposite true asian black studies moreover effect gender categorization efficiency racial black targets study finally targets race held constant gender still influenced race study findings indicate race biased presumably unrelated gender cues
compare adoption healthy lifestyle behaviors including spiritual growth nutrition physical activity interpersonal relations health responsibility stress management healthcare workers workers cross sectional observational study among convenience sample healthcare workers health promoting lifestyle profile item measure regarding six components healthy lifestyle demographic characteristics education income work duration self rated health also collected multivariable linear models specified components healthy lifestyle groups comparable age family status income self rated health results multivariable linear models revealed healthcare workers adopt better nutrition beta physical activity beta greater health responsibility beta compared differences found regard spiritual growth beta interpersonal relations beta stress management beta healthcare workers adopt better healthy lifestyle components perceived direct influence health outcomes namely nutrition physical activity health responsibility research explore reasons observed differences enable designing health improving interventions
purpose laparoscopic usually performed general anesthesia aim study investigate availability safety side effects combined spinal anesthesia comparison methods forty nine patients plan included study patients randomly divided groups intraoperative postoperative adverse events postoperative pain levels compared groups results anesthesia procedures surgeries patients successfully completed organization group patients suffered shoulder pain patients suffered abdominal discomfort complaints recovered administration patient developed recovered fluid replacement need use treatment postoperative shoulder pain significantly less observed group incidence postoperative nausea vomiting less observed group statistically significant group patients suffered urinary retention patients suffered spinal headache postoperative pain parameters except hour less observed group less vas scores less need analgesic treatment group comparing group conclusion used safely laparoscopic less postoperative surgical field pain shoulder pain advantages compared
solar energy promising energy source covering great variety applications low high temperature levels study mature technology commercial parabolic trough collector investigated great temperature range water nitrate salt sodium liquid air carbon dioxide examined working fluids one studied proper temperature range first part study optimum mass flow rate determined every working fluid separately point energetic performance collector operating working fluids examined final results prove liquid sodium leads global maximum efficiency inlet temperature equal maximum performance carbon dioxide air respectively moreover water best working medium temperature levels carbon dioxide solutions temperatures greater thermal analysis performed tool elsevier ltd rights reserved
medicine information systems provide flexible convenient health care however medical records transmitted exposed public networks vulnerable various types security threats attacks provide privacy protection secure efficient key agreement scheme urgently needed protect sensitive medical data recently proposed based key agreement scheme using hash function claimed scheme eliminate security weaknesses als scheme provide dynamic identity protection user paper however demonstrate als scheme suffers attacks man middle attacks fails provide perfect forward overcome weaknesses als scheme propose three factor key agreement scheme enable patient remote healthcare services via privacy protection chaotic map based cryptography employed proposed scheme achieve delicate balance security performance security analysis demonstrates proposed scheme various attacks provides several attractive security properties performance evaluation shows proposed scheme increases efficiency comparison related schemes
article explores psycho social space collective memory concerning massive social conceptualized third type memory image termed individuals appear remember memories family members even though either born trauma happened extremely young time experience emotional memories furthermore connect collective memories social ethnic national groups examples memories examined furthermore roles memory images play building discussed
piezoelectric based hydraulic actuator type piston cylinder device operated internal flow energy recently artificial muscle micro actuator developed using new smart material internal flow control thus velocity fabricated integrated hybrid system investigated using pumping frequency load weight velocity calculated using developed program numerical result compared experimental result validate numerical program also internal flow rate measured analyze pump efficiency experimentally flow rate inside integrated hybrid actuator calculated using cfd program various pumping frequencies compared experimental results maximum outlet velocity obtained pumping frequency velocity decreased point due flow loss
almost every child currently growing son survivors collective activity carried regime aim study communicate first impressions second generations situation examine possible effects transmission trauma based interviews parents experienced chemical attacks adolescent children strong indications found parents side irritable show dysfunctional parenting behavior form physical abuse indications boundary psychological burden including problems studying mood found among children politicians professionals need aware possible transmission parents traumatic experiences children provide adequate services
insect bacteria cause disease wide range plant species increasing availability molecular dna analyses expertise additional methods recent years led proliferation discoveries plant host associations numbers taxonomic widespread use common names based diseases associated separate taxonomic systems classifying based variation rrna encoding gene interpretation literature explore issue related trends focus australian providing first comprehensive information covering host plants vectors diseases groups reported internationally groups iii recorded australia highlights need ongoing measures prevent introduction additional pathogen groups many reported australia sufficiently studied assign groups likely groups sub groups present wide host plant ranges apparent among studied multiple crop non crop species infected disease management complicated fact putative vectors identified especially australia despite rapid progress recent years using molecular approaches remain least studied group plant pathogens making disease threat
background copy number variation known play important role genetics complex diseases several methods proposed detect association phenotypes interest statistical methods association analysis categorized two different strategies first copy number estimated maximum likelihood association expected copy number phenotype tested second observed probe intensity measurements directly used detect association phenotypes interest results strategy provide statistic applied extended families computational efficiency proposed methods enables genome wide association analysis show simulation studies proposed methods outperform existing approaches particular found first strategy always efficient second strategy matter whether copy numbers individual identified proposed methods performed genome wide association analyses hematological trait korean family samples conclusions found statistical analysis expected copy number powerful statistic probe intensity measurements regardless accuracy estimation copy numbers
background objective manual transformation dna dominant markers input tools population genetics analysis time consuming error prone task especially researcher deals large number samples addition researcher needs use several tools population genetics analysis situation due data formats across tools goal work consists patterns gel images input generation great diversity tools devoted population genetics analysis methods thorough analysis tools population genetics analysis dominant markers tools working phylogenetic trees detected input requirements systems case programs devoted phylogenetic trees formats widely employed whereas population genetics analysis tool uses specific format order handle diversity formats latter case developed new xml format called takes account variety information required population genetics analysis tool moreover acquired knowledge incorporated pipeline system tool analysing dna gel images reach goal results implemented system pipeline automatically generates gel patterns input tools population genetics analysis phylogenetic trees pipeline employed successfully generate thousands patterns input population genetics analysis tools tools managing phylogenetic trees conclusions become first tool gap gel image processing software population genetics analysis dominant markers phylogenetic reconstruction tree editing software achieved process generating input latter software gel patterns processed elsevier ireland ltd rights reserved
cell cell cell matrix communications play important roles cell proliferation differentiation gap junction proteins mediate signaling communication small molecules dramatically stimulating intracellular signaling pathways determine cell fate vertebrates gap junction families unlike functions fully understood skeletal formation abundantly expressed gap junction proteins family induced transient stage proliferation differentiation chondrocytes cells regulates osteoblast differentiation via activation intracellular signaling pathways multiple channel activities endoplasmic reticulum channels gap junctions moreover also inhibits cell proliferation promotes cell cycle exit inactivation wnt catenin signaling activation knockout mice severe skeletal abnormalities mice phenotypic analysis mice indicates regulates terminal differentiation chondrocytes promoting vascular endothelial growth factor vegf matrix metalloproteinase mmp based generation mice upstream promotes expression regulating wnt catenin signaling expression although function ways function channel via gap junction routes review discuss current knowledge regarding roles skeletal formation address potential new therapies treatment diseases pathologies associated osteoarthritis
magnets exposed magnetic fields many applications permanent magnet electric motors measured losses magnets closed circuit arrangement using fields root mean square values peak amplitude frequency range two magnet grades different content investigated around point low grade material showed significant hysteresis losses whereas losses high grade material dominated classical eddy currents microscopy images revealed hysteresis losses measured low grade magnet mainly ascribed grains sample surface multiple domains confirmed high grade material subsequently exposed magnetic fields larger number surface grains multiple domains also present step curve attributed surface grain reversal reached rise measured hysteresis losses evident low grade material operating point slightly offset point zero field losses also fairly described classical eddy current theory elsevier rights reserved
background science drug metabolism pharmacokinetics plays critical role supporting selection potent selective leads retain appropriate physicochemical properties ensure distribution site administration tissue target interest historically discovery gap disciplines biology medicinal chemistry thereby ensuring clinical focus discovery early development phases objective discuss fundamentals screening drug discovery historical perspective highlighting part improving chances success novel drug candidates suggesting new exciting areas future development conclusions broad resulted development wide variety assays vitro vivo focused assessing risks associated molecules progression clinical development likely bioavailability humans potential drug drug interactions human metabolism interactions transporters potential metabolism mediated toxicity arguably already adopted many concepts now interest translational medicine quantitative pharmacology scientific regulatory pressures continue drive subject towards better integrated approaches systems thinking
operation signal flow graph sfg graphical approach analyzing intricate photonic circuits mathematically quick calculation optical transfer function analysis cascaded made semiconductor presented using signal flow graph sfg method enables modelling transfer function passive passive filters mostly characterized frequency response theoretical calculations system performed effects analysis two radius vertically coupled together used generate resonant peaks phase dispersion group delay generated signals analyzed
charge recombination dark current two main negative processes dye sensitized solar cells herein new electron donor group developed resist charge recombination dark current sensitized solar cells new donor group moiety therefore outperforms conventional moiety higher electron donor ability evidenced vis spectroscopic analysis furthermore structure help resist dark current charge recombination demonstrated dark current electrochemical impedance spectroscopic eis studies including novel donor group achieves higher energy conversion efficiency conventional elsevier ltd rights reserved
polymer materials represents major limitation use hence development polymer based advanced technologies environmental safety concerns leading progressive versatile effective based fire far ensured satisfactory polymer fire hazard control among intensive efforts made develop new environmentally safe polymer fire protection approaches recognition paramount role played polymer surface combustion exploitation new developed polymer surface engineering offer promising perspective polymer fire indeed heat transfer polymer diffusion gas phase polymer degradation fuel combustion occur across polymer surface characteristics regulate polymer combustion process shown engineering polymer material surface coatings layer layer nano deposition nanostructures gel synthesis polymer combustion conveniently fire safety rules specific applications creation surface barrier heat mass transfer across polymer surface elsevier rights reserved
background aim study investigate reliability automated blood pressure monitoring presence absence atrial fibrillation hypertensive patients methods measured compared randomly selected patients arterial hypertension diagnosis times detection system methods results study included patients males mean age years females years time measuring procedure patients sinus rhythm patients mean systolic blood pressure mmhg method mmhg method mean diastolic mmhg mmhg patients mean mmhg mmhg mean diastolic mmhg mmhg differences sinus rhythm group mmhg limits agreement mmhg limits agreement respectively patients differences mmhg limits agreement mmhg limits agreement respectively conclusions device validated patients average gives mmhg higher systolic values patients mmhg higher values patients however limits agreement two methods reveal wide range random error rates topic clinical practice possibly affect treatment arterial hypertension patients
although missing data methods advanced recent years devoted less attention multilevel data structures observations level nested within higher order organizational units level individuals within neighborhoods repeated measures nested within individuals students nested within classrooms joint modeling equations principal frameworks single level data multilevel counterparts approaches differ functionality appropriate simple random analyses normally distributed data differ beyond purpose paper describe multilevel strategies evaluate performance variety common analysis models using multiple theory computer simulations derive major conclusions joint modeling equations appropriate random analyses joint model superior analyses different within cluster associations multilevel regression model includes level predictor cluster means multilevel structural equation model different path values level level equations provides dramatic improvement joint modeling random slope analyses latent variable formulation categorical variables quite effective use real data analysis demonstrate multilevel suggest number avenues future research
development agriculture industry urbanization land use land cover change resulted significant deterioration water quality severe lakes china plateau lake ecosystem china vulnerable especially sensitive environmental change human disturbance due strong species simplification simple food chain research focuses evaluating quantitative spatial relationships land use pattern water quality rivers lake chinas largest deep freshwater lake plateau investigate influence spatial variation land use structures topography rivers water quality distributions land use types lakes drainage basin obtained satellite images correlations land use types inflow water quality indicators examined applying statistical analysis spatial analytical function geographic information system level analysis reveals land use type exert different effects water quality effects connection topographic hydrologic factors mixture land use types weather conditions field measurements scale addition comparison correlation coefficient data buffer regions different scales indicated effect land use type inflow water quality peaked buffer regions radius whole regions within river banks key regions affected river water quality thus construction preservation buffer zone regions provide considerable protection inputs non point source pollutants nutrients important function water soil conservation based pollution control constructed two key pollution control zones north south phosphate rock pollution control zone northeast water loss soil erosion control zone east tourism pollution control zone west research also offers valuable insights carry level prevention control water pollution regional development according natural environment land use pattern characteristics pollution sources different pollution control zones elsevier rights reserved
controversy exists violent harmful infants absence impact study objective characterize biomechanical response infant head use instrumented test device commonly referred test surrogate representing human infant improved series tests conducted simulate violent infant surrogate infant surrogate represented percentile japanese newborn percentile japanese adult male recruited infant surrogate sagittal plane linear accelerometers positioned center mass head recorded accelerations five test series sec duration conducted outcome measures derived accelerometer recordings examined trends head neck kinematics characterized events mean peak neck flexion degrees mean peak neck extension degrees maximum angular acceleration across test series sec chest contact peak angular velocity sec chest contact acceleration pulse durations ranged using infant surrogate improved found higher angular acceleration higher angular velocity previously reported infant surrogate experiments findings highlight importance surrogate investigating
chronic lymphocytic inflammation enhancement responsive steroids steroid sensitive steroid dependent brainstem inflammatory disease unknown origin since first description cases reported throughout world mean age onset years men seem frequently affected patients without chronic corticosteroid therapy immunosuppressive agents disease relapsing remitting course mean relapse rate attacks although clinical radiological improvement high doses corticosteroids systematically observed patients display subsequent disability atrophy since progressive course observed clinical radiological sequelae correlated previous severe attacks therefore maintaining disease remission prevent accumulation disability literature relapse occurred chronic corticosteroid therapy maintained per day however steroids side effects led propose corticosteroid therapies unfortunately controlled therapy studies performed yet therapeutic recommendations exist using pubmed database articles following keywords chronic lymphocytic inflammation enhancement responsive steroids analysed considering mean annual relapse rate relapse occurred corticosteroid therapy maintained per day therapeutic efficiency corticosteroid agents considered probable patients relapse free period months absence concomitant corticosteroid therapy corticosteroid agents whose efficiency probable methotrexate two cases one case one case considering risk benefit ratio corticosteroid agents methotrexate seems suitable nevertheless randomized controlled trials testing different corticosteroid agents necessary
objectives besides group streptococcus gas microbial causes children known aimed document viral bacterial aetiology assess pathogenic role viruses determining resistance protein blood marker interferon response methods prospective observational study blood samples collected children age years presenting emergency department microbial cause sought bacterial culture polymerase chain reaction blood level determined results potential pathogen detected patients gas alone gas viruses group alone together viruses viruses alone cases frequently detected viruses blood levels higher children viral median iqr concomitant gas viral sole gas infections conclusions detection respiratory viruses simultaneously elevated blood levels supports causative role viruses majority children british infection association published elsevier ltd rights reserved
pharmacokinetics major metabolite evaluated subjects varying degrees renal impairment men women renal impairment estimated glomerular filtration rate min mild min moderate min severe healthy matched control subjects received single oral dose plasma metabolite concentrations determined pharmacokinetic parameters calculated samples obtained hours subjects mild moderate renal impairment pharmacokinetic profiles similar healthy matched subjects subjects severe renal impairment elimination significantly slower exposures based area plasma concentration versus time curve time zero extrapolated infinity maximum observed plasma concentration increased versus healthy matched subjects metabolite pharmacokinetic profiles subjects mild renal impairment similar healthy matched subjects however increased moderate severe impaired subjects dose reduction recommended individuals severe renal impairment mild moderate renal impairment
injury major women elite athletes research primarily focused physical recovery treatment psychological resilience plays crucial role recovery order assess prevalence injuries strategies coping used elite athletes recover injuries men women registered spanish national assessed participants answered questionnaire sports injuries athletic coping skills inventory results revealed probability suffering sports injury significant similar different stages training athletes adopt just one coping style combination adaptive maladaptive strategies maintenance stage performance gains athletes fewer maladaptive strategies male use different strategies female cope injury results support model implications intervention discussed
clinical depression affects physicians including radiologists medical professionals including radiologists comfortable treating patient one psychiatric issues regarded discussion issue clinical depression specialty received widespread attention specifically review national international literature pubmed scopus google reveals publications dedicated issue clinical depression radiology although statistically exist purpose report define terms describe manifestations scope issues related clinical depression special attention given risk factors unique radiologists working low ambient light near different fields magnetic strength end article authors hope reading aware open possibility clinical depression within clinical depression common important get help
paper addresses problem finding sources among social network users detect prevent various malicious activities spreading false information potentially inflammatory topic accounts false identities etc existing research works related source credibility graph based considering relationships among users predict spread information human based using human perspectives determine reliable sources machine learning based relying training classifiers predict users credibility approaches consider users analyzing credibility source paper propose novel approach combines analysis users reputation given topic within social network measure users identify relevant sources information particular propose new reputation metric introduces several new features existing models evaluated performance proposed metric comparison two machine learning techniques determining accuracy proposed approach satisfies stated purpose identifying users copyright john wiley sons ltd
video object tracking represents important computer vision domain paper perceptual based template matching method object tracking proposed efficiently track objects challenging video sequences tracking process first apply three existing basic perceptual techniques visual tracking namely average hash hash difference hash compared previous tracking methods mean shift compressive tracking perceptual based tracking outperforms terms efficiency accuracy order improve accuracy object localization robustness tracking propose laplace based hash laplace based difference hash qualitative quantitative comparison representative tracking algorithms experimental results show improved perceptual based tracking algorithms perform favorably state art algorithms various challenging environments terms time cost accuracy robustness since improved perceptual compact efficient representation objects applied depth information robust rgb video tracking
standard solution methods models necessarily deliver minimal state space forms form non minimal conditions literature necessary existence var representation paper present necessary sufficient conditions valid general hence applied minimal non minimal forms state space form minimal conditions literature results also clarify possible unstable eigenvalues together possibly finite var representation
study design cross sectional objective describe physical activity level fracture rates adults idiopathic diagnosed maturity compare control group summary background data previous study found lower level sporting activities adults treated idiopathic compared controls studies shown lower bone mass adults idiopathic compared controls methods one thousand two hundred seventy eight adults aged idiopathic controls aged included answered international physical activity questionnaire short form questions previous fractures three treatment groups untreated surgically treated compared furthermore comparison based onset juvenile adolescent performed achieved weekly moderate activity level metabolic equivalent task met minutes week assessed patients controls statistical comparisons made analysis covariance adjustments age body mass index sex results proportion achieving weekly moderate activity level individuals idiopathic controls patients reported minutes week median value controls fracture rates differ fewer surgically treated individuals achieved moderate activity level compared untreated previously individuals difference seen regarding met minutes week differences seen individuals juvenile onset compared individuals adolescent onset conclusion adults idiopathic similar physical activity level sustain fractures compared controls adults surgically treated idiopathic slightly lower physical activity level previously untreated patients onset idiopathic affect physical activity level
background purpose now known post transplant graft function donor liver transplantation living donor liver transplantation differ however report assessing relationship graft function development new onset diabetes mellitus transplantation conducted study identify predictive risk factors including graft function methods subjects study adult recipients underwent university hospital survived months median observation period days results year incidences respectively pre transplant diabetes associated poor survival whereas associated patient survival multivariate analysis recipient age trough level months months independent risk factors conclusions poor graft synthetic function months older age recipient higher concentration strongly associated development
die model characterized high design efficiency strong correlation plays important role simulation machining complexity structure changing shape flow channel current design tools lack level automation design die task paper integral design method proposed improve design efficiency model correlation computer aided design cad system plastic profile die designed implemented integrating visual closed loop recognition algorithm multi closed loops intelligent recognition algorithm multi closed loops matching algorithm based feature recognition proposed realize automatic generation ruled surface flow channel integral design automatic generation methods die set proposed facilitate efficient formation different structures process holes particle swarm optimization pso algorithm put forward obtain best position specification interference parts three modules integral integral flow channel integral die set developed focus integrating proposed automation design methods framework case application die design used illustrate proposed method results show developed cad system improves design efficiency die also enhances design quality
optical sampling scheme using single semiconductor optical amplifier proposed analog signal processing analog optical signal sampled probe pulse train nonlinear polarization rotation arising semiconductor optical amplifier conversion efficiency total harmonic distortion presented evaluate sampling linearity experiment optical sampling ghz analog optical signal successfully demonstrated commercially available fiber components results show fundamental conversion efficiency total harmonic distortion operating power respectively proposed optical sampling requires one semiconductor optical amplifier low power consumption simple potential photonic integration elsevier rights reserved
interpreting results functional analysis clinician conclude automatic function either problem behavior elevated alone ignore condition relative conditions problem behavior elevated undifferentiated across multiple conditions latter difficult determine problem behavior maintained automatic reinforcement alone maintained current study tested maintained self behavior exhibited two participants implementing functional analysis controlling automatic reinforcement sensory extinction results suggest self injury maintained automatic reinforcement alone one participant automatic reinforcement physical attention another participant results used create function based treatments self injury successfully generalized across settings caregivers
awareness knowledge emergency contraception less among usually southern states india better performance family planning northern states hence considered study district level health survey data source several socio economic demographic variables considered determinants analysis revealed state highest awareness followed lastly logistic regression revealed less knowledge emergency contraception better knowledge scheduled respondents also less knowledge emergency contraception years respondents also emerged important variables affecting knowledge emergency contraception
widely used effective biologic treatment chronic plaque psoriasis prospective studies specifically investigated clinical factors influence treatment outcomes post hoc analysis aimed identify specific clinical factors influence treatment outcomes psoriasis patients study korean patients moderate severe psoriasis analyzed assess influence baseline characteristics clinical factors clinical response improvement psoriasis area severity index addition differences responses group non responders evaluated weeks multiple logistic regression analysis used determine adjusted clinical factors predicting treatment outcomes among patient characteristics week significant difference response based prior biologic experience although difference persist week addition adjusting effects relevant clinical factors biologic experience significantly associated less odds ratio responses week presence comorbidities higher among non responders among responders weeks statistically significant previous biologic use clinical factor predicting less response week although influence clinical response week studies warranted investigate association presence comorbidities clinical response
case measurement noise involves impulsive interference distributed estimation algorithms based mean square error criterion suffer severely degraded convergence performance divergence address problem modify adapt combine diffusion algorithm applying sign operation error signals agents develop diffusion sign error algorithm furthermore stochastic behavior algorithm analyzed gaussian inputs contaminated gaussian noise based prices theorem simulation results show robustness algorithm impulsive interference validate theoretical findings elsevier rights reserved
research investigates fundamental desire control affects product acquisition authors propose consumers compensate loss perceived control products household cleaning agents products association problem solving quality promotes sense control study demonstrates basic effect field setting involving real studies show framing product effect control purchase intentions study shows generalized problem solving tendency mediates effect control pursue consumption given ease using product acquisition means cope psychological threat research important implications theory practice
technology rapidly changing nature service customers service experiences customers relationships service providers based prediction technology service providing robots numerous service experiences article ability engage customers social level critical advancement technology specifically introduces novel concept automated social presence asp extent technology makes customers feel presence another social entity services literature authors develop typology highlights different combinations automated human social presence organizational indicates literature gaps thereby emphasizing avenues future research moreover article presents conceptual framework focuses relationship asp several key service customer outcomes mediated social cognition perceptions psychological ownership three customer related factors moderate relationship asp social cognition psychological ownership customers relationship orientation tendency technology readiness finally presented catalyst future work enhance understanding technology infusion particularly service robots influences customers experiences future
note find constructions non splitting functions thus solving open problem technical conditions also construct functions level splitting functions level elsevier rights reserved
purpose risk factors associated clients major impact successful delivery project early design construction operation stages risk management studies conducted far providing effective risk assessment methodology clients analysing managing risk factors cause project delays cost purpose paper provide methodology client based risk management model design methodology approach conceptual framework designed integrating findings literature review construction industry survey kingdom saudi arabia framework includes risk identification risk analysis mitigation strategy key components model model framework developed integrating analytical hierarchy process ahp monte carlo simulation within program findings case study used demonstrate proposed methodology results found model helps analyse quantify impact risk factors also assist taking suitable risk mitigation strategy particularly early design stage construction process practical implications model applicable public private clients need know possible project duration new construction project take proactive actions avoid adverse effect client risk factors early stage project originality value model expected help understanding nature analysing influence client risk factors cause project delays cost development methodology managing client based risk construction processes early design stage key value study
polymers wide applications biomedical engineering marine industry recently materials reported promising candidates applications strong hydration believed key mechanism materials designed various molecular structures affect hydration performance although strong hydration proposed occur material surfaces probing solid material water interfaces challenging traditional analytical techniques review review studies surface hydration materials materials using sum frequency generation sfg spectroscopy provides molecular understanding water structures various material surfaces materials studied include polymer different molecular structures polymers groups hydrophilic polymer widely used material poly ethylene glycol compare differences among materials various molecular structures differences materials surfaces control samples also discuss effects biological molecules like proteins surface hydration materials using sfg spectroscopy measured hydration layers materials found strong hydrogen bonds key formation strong hydration layers preventing protein polymer interfaces statement significance polymers wide applications biomedical engineering marine industry recently materials reported promising candidates applications strong hydration believed key mechanism however materials designed various molecular structures affect hydration performance moreover although strong hydration proposed occur material surfaces probing solid material water interfaces challenging traditional analytical techniques manuscript review studies surface hydration materials materials using sum frequency generation sfg spectroscopy provides molecular understanding water structures various material surfaces materials studied include polymer different molecular structures polymers groups hydrophilic polymer widely used material poly ethylene glycol compare differences among materials various molecular structures differences materials surfaces control samples also discuss effects biological molecules like proteins surface hydration materials sfg results indicate strongly hydrogen bonded water materials surfaces strong surface hydration closely correlated good properties materials review widely interested readers impact many different research fields chemistry materials engineering beyond inc published elsevier ltd rights reserved
advances molecular biology biochemistry provided tools explore increase understanding mediators regulate development pathological changes pulmonary circulation combinations techniques allowed researchers start unravel complex biological pathways direct relevance pulmonary research contribute cellular proliferation vascular permeability aim chapter describe established protocols quantify dna rna protein expression discuss advances techniques illustrate applied expression levels cell signaling components detected level dna rna protein southern blotting also termed southern hybridization named southern developed technique allows detection specific dna sequence preparation dna typically cellular nuclei method modified extended later detection rna protein named northern western respectively three protocols based similar principles utilize similar methods alternatively measurement gene expression using messenger rna mrna starting material generation complementary dna cdna also performed via reverse transcription polymerase chain reaction pcr followed gel electrophoresis modification technique real time pcr also termed quantitative pcr allows quantitative analysis gene copy number number high throughput techniques exist profiling gene protein expression use dna protein microarrays however discussed detail subsequent sections many variations exist protocols outlined made using variety number however principles remain understanding stages process purpose key chapter outlines methods proven versatile reliable sensitive
objectiveto investigate baseline shape weight concern moderated outcomes prevention across spectrum randomized controlled trial rct school based programs aimed reducing eating disorder obesity risk factors grade girls boys age years across three australian states randomly allocated media smart life smart helping encouraging listening protecting peers initiative control usual school class moderation explored testing interaction effects group media smart life smart control moderator higher lower time post program month follow month follow baseline risk factor scores entered covariates effects found shape concern weight concern eating concern regular eating meal physical activity body dissatisfaction post hoc testing found eating concern post program variable higher media smart participants experienced reduction risk relative controls higher life smart participants reported increase eating concern relative controls groups meals controls month follow amongst lower participants media smart group experience benefit relative controls physical activity study highlights need moderator analyses become routinely conducted universal trials ensure participants across baseline risk levels program participation wiley periodicals inc int eat
rna interference strategies offer alternative small molecular drug targeting small interfering rna sirna constitutes class molecules allows effective specific inhibition biosynthesis protein indeed sirna emerged major tool molecular biology techniques important approach identify suitable therapy targets cancer however sirna therapy approaches vivo scarce two major problems hinder sirna therapeutic tool delivery leads degradation rapid renal clearance stabilization specific uptake desired cell type specificity review summarizes ongoing attempts use rnai disease causing factors compare methods stabilize sirna different conjugates complexes targeting molecules antibodies single chain fragments enable specific uptake carriers respective cells propose development antibody coupled sirna complexes shown allow stabilization targeted uptake sirna cancer cells
academics higher education institutions often experience conflicting demands teaching research administration growth online education staff frequently required design develop teach facilitate cases online courses additional tasks challenge academics terms personal professional development also range tasks expected paper reports findings study investigated lived experience construction management academics teaching universities australia study adopted lived experience research approach enabled lives construction management academics investigated collection mixture qualitative quantitative data study provides empirical evidence range challenges facing delivering online courses recommendations online teachers online course designers emerged study application faculty based institution wide practices findings relevant higher education sector involved online teaching course design online delivery professional development related online initiatives
widely used anti infectious beta antibiotics clinic purpose increasing yield fermentation especially industrial strain genes encode ultimate steps biosynthesis encodes efflux pump encodes bacterial hemoglobin gene transformed various combinations industrial strain pcr southern blotting indicated introduced genes integrated chromosome carbon monoxide difference spectrum absorbance assay performed result showed hemoglobin successfully expressed biological activity hplc analysis fermentation recombinant showed transformants higher production level parental strain multiple transformants containing additional copy showed significant increase production however showed little effect production high highest improvement observed mutant extra copy whose production increased first report three genes introduced simultaneously results also demonstrated combination genes synergy effect high
dedicated crop suitable production industrial genetic modification progressed substantially last years transformation efficiency needs improved meanwhile developing reliable molecular system including southern blot qrt pcr analyses desired effectively evaluating transgenic lines gene expression levels endogenous study developed efficient transformation protocol selective agent transformation regeneration test addition concentration resulted shoot regeneration using explants regeneration occurred concentration reached based result concentration used subsequent transformations results showed transformation efficiency constant low selection pressure similar higher selection pressure first followed transfer lower selection pressure southern blot fatty acid composition analyses confirmed integration genome also optimized southern qrt pcr methods future studies related species southern blot analysis dna required clear band choice enzymes dna digestion rigid confirmation dna integration determining copy number suitable enzymes chosen increasing enzyme concentration improve digestion enzyme complete digestion dna qrt pcr analysis around days observed suitable sampling time analysis genes seed oil biosynthesis
background compact grass family potential enable research unlike large genome self long life cycle large suboptimal traits rapid genetics research herein improved tissue culture methodologies two populations enable development model plant results optimal seed derived induction medium determined medium supplemented cysteine proline sucrose acid resulted induction optimal derived induction observed medium medium supplemented proline resulting induction shoot regeneration rates shoots gram shoots gram achieved using seed induced whereas shoot regeneration rates shoots gram shoots gram achieved induced cell suspension cultures established seed derived providing faster generation tissue compared culture using media fold increase fold increase conclusions tissue culture times induction plant regeneration noted apparent differences populations tissue culture performance populations cell suspension cultures outperformed tissue cultures media using methods developed work induced seeds immediately harvest shorter time higher frequencies clonal propagation established similar potential plant model genetic studies rapid cycling seed seed time ease culture demonstrate potential utility model plant
frontotemporal degeneration neuropathological disorder causes variety clinical syndromes including frontotemporal dementia progressive palsy syndrome associated occurs frequently result mutations gene also genes coding protein associated microtubule tau chromosome herein report family extensive family history behavioral variant twenty one members generations composed extensive neurologic neurocognitive examination performed symptomatic individuals non symptomatic individuals two different phenotypes identified among affected members dna extracted blood individuals whole exome sequencing performed followed sanger sequencing candidate genes affected individuals missense mutation exon gene identified among mutations frequently associated different phenotypes aggressive symmetrical onset late associated progressive palsy reported associated first report occurrence mutation south america supports marked phenotypic heterogeneity among members family previously reported published elsevier inc
performance enhanced free spectral range triple ring resonator architecture presented using delay line signal processing technique signal flow graph group delay dispersion presented mathematical model developed domain enhanced suppression crosstalk prime objective larger ring
paper presents development intelligent temperature frequency converter measure temperature using negative temperature coefficient signal conditioning circuit scc modified circuit whose control voltage generated difference amplifier scc acts temperature frequency converter exhibits moderate linear temperature frequency characteristic range degrees linearity error multilayer neural network algorithm used modeling nonlinearity estimation converter algorithm effectively reduces linearity error compared scaled conjugate gradient algorithms mean square error regression coefficients linearity accuracy dispersion spread used evaluate performance proposed ann based modeling intelligence ann based modeling embedded low cost microcontroller unit performance experimentally verified prototype unit linearity error sensitivity proposed unit approximately khz degrees respectively elsevier ltd rights reserved
conducted prospective study assess prognostic impact selected copy number variations stage iii microsatellite stable colon cancer total patients included selected target genes egfr myc detected using quantitative multiplex polymerase chain reaction short fluorescent fragment method primary end point impact year disease free survival recurrence rate years corresponding stage patients versus stage iii patients year significantly decreased patients loss gain multivariate analysis demonstrated stage iii loss gain independent factors associated combination also associated relapse hazard ratio increasing confidence interval presence alterations respectively significantly associated stage iii colon cancer
receptor represents atp gated receptor selective localization alveolar epithelial type cells lung despite involvement receptor inflammatory processes lung established whether receptor plays specific role alveolar epithelial cell biology evidence receptor influences wnt beta catenin signalling pathways alveolar epithelial cells conditions injury investigated expression beta potent protein kinase involved alveolar epithelial barrier functions tight junction molecules wild type mice western blot analysis immunohistochemistry quantitative real time pcr revealed remarkable increase mrna protein lungs mice animals furthermore alveolar epithelial cells animals showed decreased levels beta protein inactive form beta conversely knockout mice exhibited decreased mrna transcript abundance measured mrna expression microarray quantitative pcr data consistent hypothesis contributes alveolar epithelial barrier function effects beta furthermore data suggest potential reciprocal regulation alveolar epithelium
smart based film bis para responsive prepared film simultaneously harness chemical potential light aerial humidity gradients convert mechanical work strong reversible matrix induces locomotion mechanical deformation owing exchange water surroundings driven humidity composite film coupled piezoelectric bending transducer sensor generates peak output approximately corresponds power density excitation light triggers appears bending film material also responds changes reversible rapid changes color fluorescence sensing capability smart material utilized fabrication dynamic elements soft robotics
paper consider weak center conditions local critical periods cubic system eleven center conditions center using computer algebra system compute period constants obtain order weak center every center condition separately finally number local critical periods center given symbolic computation numerical computation
rendering performance goal computer graphics significant driver advances hardware architecture algorithms thereby become possible apply advanced computer graphics technology even low cost embedded appliances car instruments yet come efficient implementation developers put enormous efforts hardware problem specific tailoring fine tuning domain exploration requires profound expert knowledge good solution found high probability work architectures even next hardware generation generative based approaches mitigate efforts provide efficient exploration algorithmic variants hardware specific tuning ideas however vertically organized industries automotive introduce techniques fear loss control high introduction costs additional constraints imposed respect software tool chain certification moreover want share generic solutions concrete instances end propose light weight incremental approach meta programming graphics applications approach relies existing formulation like languages amenable meta programming extend become lightweight language combine algorithmic features method provides concise meta programs generates easily output appropriate style target language
expression glucose transporter type isoform gene adipocytes subject hormonal metabolic control present study characterized adipose tissue transcription factor influenced fasting regimens insulin northern blotting showed increased mrna levels adipose tissue consistent increased gene expression mrna levels regulatory element binding protein adipose tissue also increased streptozotocin induced diabetic rats insulin treatment increased mrna levels adipose tissue serial deletion luciferase reporter assays electrophoretic mobility shift assay studies indicated putative response element located region bases human promoter transduction dominant negative form differentiated adipocytes caused reduction mrna levels suggesting mediates transcription vivo chromatin immunoprecipitation revealed increased binding putative response element furthermore treating streptozotocin induced diabetic rats insulin restored binding addition identified binding site adjacent functional response element promoter site appears play additive role mediated gene upregulation results suggest upregulation gene transcription directly mediated adipose tissue
solve problems climate change every little push counts community energy schemes popular policy targeted reduce carbon emissions effect energy use depends whether people work together community often find dilemma others bit experiment participants matched groups play collective risk game framed community energy purchase scheme made one decision energy use virtual household day full round game lasted week real time decisions entered via personal phone home computer end week group exceeded pre paid threshold energy use group members share fine day participants received feedback decisions group partners groups feedback manipulated high condition low fair condition use high average group use created individual risk participants end week even use much found risk pay fine participants stayed significantly fair share threshold regardless behavior others contrary significantly decreased consumption toward end game seeing others bit using fair share encouraged people take advantage situation played fair follow normative behavior conversely increased consumption course game opportunistic strategies demonstrated impulsive participants also low punishment sensitivity discuss findings light policy research literature cooperation prosocial behavior
objectives treatment inflammatory bowel disease ibd revolutionized use immunomodulatory agents although potent drugs effective controlling disease activity also cause increased risk new infections reactivation latent infections aimed provide guidance definitions immunocompromised patients opportunistic infections risk factors associated occurrence ibd context suggest proper screening tests infectious diseases vaccination schedules perform therapy methods recent evidences filtered combined work infectious disease experts summarized aim provide practical physician results systematic screening infections arise therapy drugs necessary patients ibd conclusions ideal timing perform screening tests diagnosis disease regardless severity onset course ibd treatment vary time immunocompromised status efficacy possibility perform necessary vaccines british infection association published elsevier ltd rights reserved
salt widely used electrolyte fuel cell high ionic conductivity operating temperature major objective study investigate thermal stability binary salt phase change material thermal energy storage thermal decomposition analysis different environments thermal cycling composition binary salt determined using software properties experimentally investigated using simultaneous thermal analyzer ray diffraction results show salt melting point degrees degrees heat fusion heat thermal decomposition analysis indicates salt good thermal stability environment without weight loss temperatures degrees however weight loss observed degrees atmosphere associated thermal decomposition salt produce corresponding metal oxides environment inhibit thermal decomposition thus resulting higher thermal stability binary salt hence operating environment large effect thermal stability salt salt exhibits high thermal stability thermal cycles little change thermal properties compared initial sample published elsevier
purpose review atrial fibrillation important cause morbidity aging population mechanisms responsible triggering maintenance chaotic atrial rhythm still poorly understood review focus genetic aspects atrial fibrillation understand causality special emphasis recent studies published field recent findings diseases hypertension heart disease heart failure induce atrial fibrillation increases risk stroke sudden cardiac death clinical studies published last two decades provided evidence genetics play key role atrial fibrillation thus family history disease identified clinically diagnosed patients genotyped families carry rare genetic variants genes associated ionic channels calcium handling protein predisposing fibrosis conduction system disease inflammatory processes summary currently atrial fibrillation common sustained arrhythmia clinical practice pathophysiological mechanisms atrial fibrillation complex better understanding molecular basis help improve current risk stratification clinical management
diabetes mellitus highly prevalent condition affecting million people worldwide addition numerous clinical implications also exerts negative effect patients sleep quality impaired sleep quality adequate glycemic control regarded corner stone management also lead many deleterious effects causing profound impact health related quality life article outlines various factors leading impaired sleep quality among individual factor influences sleep article also discusses potential interventions lifestyle changes promote healthy sleep among
virtually known glucocorticoid receptor receptor gene expression avian species report cloning partial chicken partial used probes characterize expression mrna identify full length transcripts within chicken genome chicken sequences predicted genome sequence compared representatives vertebrate classes genes located chicken chromosomes respectively northern blotting reverse transcription polymerase chain reaction pcr results indicate widely expressed many tissues characterization mrna levels anterior pituitary gland embryonic development quantitative real time pcr demonstrates decreased increased gene expression embryonic days plasma levels corticosteroids increased period first study gene expression avian species first analysis changes pituitary gene expression embryonic development species elsevier inc rights reserved
objective usage recognized prominent substance abuse issue exercise training improves fitness mental status dependent exercise training affects addiction cognitive deficiency yet established current study aimed determine effects aerobic exercise training associated inhibitory control among dependencies design week randomized controlled trial method sixty two people dependencies recruited drug rehabilitation assigned either aerobic exercise attentional control group participants completing trial aerobic exercise program involved three min sessions moderate intensity exercise per week along pre test assessment levels evaluated every three weeks data neutral related inhibitory control elicited activation collected end intervention results compared control group exercise group experienced attenuated levels weeks exercise program decreased trend maintained termination treatment post test exercise group also demonstrated accuracy behavioral inhibitory control greater amplitude condition standard related tasks control group pre test conclusions current study provides first evidence aerobic exercise training efficacious associated inhibitory control behavioral perspectives among dependent individuals published elsevier ltd
improve energy conversion ability utilize renewable resources first put forward concept internet energy although peer peer energy sharing mechanism achieved directional energy transportation approach solving cooperative energy transportation storage still needs improving traditionally redundant energy consumed power load fact redundant energy stored supply power loads future end investigate cooperative energy transportation storage terms problem analysis algorithm design platform development demonstrating feasibility condition proving hard problem derive optimal solution reduction classic problem also design novel heuristics followed different energy storage strategies addition based software defined networking complementary platform developed make effective decision cooperative energy transportation storage using heuristics simulation experimental results demonstrate effectiveness solutions
background idiopathic pulmonary fibrosis ipf progressive interstitial lung disease evaluating predictor mortality ipf patients crucial aim study evaluate serial trend important indicators prognosis create useful staging method ipf patients methods retrospectively searched medical records pulmonary function tests chest high resolution computed tomography scans january june hospital also evaluated parameters year later results identified ipf patients mean age years range years terms mean percent predicted forced vital capacity fvc baseline mean body mass index bmi mean survival months range months cox proportional hazard ratios hrs showed following predictors mortality ipf patients year bmi year fvc year respiratory hospitalization basis date created new staging method predicting mortality ipf patients consisting delta bmi delta fvc respiratory hospitalization within year following diagnosis ipf staging stratified patients one three groups according composite points mean survival stages months respectively conclusions cohort ipf patients new staging method including delta bmi delta fvc respiratory hospitalization within year showed clear survival difference
also known type humanized antibody targets antigen expressed surface cells novel anti antibody currently assessed clinical trials promising results single agent part therapeutic combinations treatment cell malignancies detailed understanding mechanisms induced cell death needed get insight possible resistance mechanisms occurring patients although multiple vitro vivo mechanisms suggested describe effects cells currently available data ambiguous aim study clarify cellular mechanisms involved induced cell death vitro particularly respective roles played lysosomal mitochondrial membrane results confirm previous reports suggesting triggers adhesion caspase independent cell death two processes dependent actin remodeling involve production reactive oxygen species respect lysosomal membrane data suggest lack specificity available antibodies directed previously published results possibly challenging current driven model action mode elsevier ltd rights reserved
proteins initially discovered regulators alternative splicing process controlled removal selective joining exons multiple transcripts subsequently proteins expressed single gene alternative splicing affects genes involved crucial cellular processes including apoptosis impaired apoptotic control facilitates survival cells bearing molecular aberrations contributing proliferation apparently proteins regulate levels expression apoptotic genes including transcription initiation elongation alternative splicing mrna stability translation protein degradation frequently disturbed expressions proteins cancers lead impaired functioning target apoptotic genes including regulators extrinsic fas caspase caspase intrinsic pathway caspase genes encoding bcl proteins tumor suppressor prototypical members families promote synthesis anti apoptotic splice variants bcl results attenuation programmed cell death breast cancer chronic myeloid leukemia proteins significantly affect responses chemotherapy acting mediators modulators drug induced apoptosis aberrant expression interfere tumor responses chemotherapy pancreatic liver cancers currently number splicing factor inhibitors tested pre clinical clinical trials review discuss recent findings role proteins apoptotic control cancer cells significance anticancer treatments elsevier rights reserved
greater pain syndrome common clinical entity effective treatment local corticosteroid injection studies effect among patients hypothalamic pituitary adrenal axis present study recruited patients diagnosed participants received low dose hormone stimulation test immediately following test participants received acetate greater region stimulation test repeated weeks following cortisol samples obtained just prior basal min post stimulation following every stimulation test serum cortisol levels mol obtained min following stimulation test considered evidence secondary adrenal insufficiency study enrolled patients completed participation female participants similar mean age participants years four participants showed evidence secondary adrenal insufficiency observed weeks following mean serum cortisol level among four participants min following stimulation test mol range mol acetate greater area among patients associated transient secondary adrenal insufficiency similar patients mainly week following injection
address issue large scale network security known traditional game theory becomes intractable considering large number players realistic situation todays networks centralized administration available propose new model based mean field theory allows obtain optimal defence policy node network optimal attack policy attacker way promising framework development mean field game theory large scale network security also present case study experimental results
falling significantly affects quality life morbidity mortality among older adults sought evaluate prospective association sedentary time physical activity falling among post menopausal women aged years recruited womens health initiative observational study clinical centers across united states baseline change following evaluated year year baseline recreational physical activity met sleeping min day lean body mass dual energy ray absorptiometry subset falls per year assessed annually self report questionnaire falls year logistic regression models adjusted demographics body mass index fall history tobacco alcohol use medical conditions medications higher baseline activity associated greater risk falling trend met increased falling trend adding lean body mass models attenuated relationships physically active lifestyles increased falling among post menopausal women additional fall prevention strategies balance resistance training evaluated assist post menopausal women reaching maintaining levels aerobic activity known prevent manage several chronic diseases elsevier inc rights reserved
paper explores continuity change american promotion later reliance religious freedom analysis spanning years first traces pressures reform created years ago demonstrating american crucial actors existence passage case strong pressures leaders predominantly country paper turns summary birth control affordable care act created pressures american hierarchy pressures articulated terms demonstrates although specific changed remain central discussions stance birth control affordable care act
examination age sex gender sex gender hiv vaccine studies contribute understanding demographic variables preparation actual hiv vaccine trials descriptive review age sex gender sex gender examined relation willingness participate retention hiv vaccine trial twenty five articles retrieved organization economic operation development countries articles retrieved non countries studies involved mainly white msm older men likely hypothetical hiv vaccine trial likely retained younger men studies sex gender associated hypothetical hiv vaccine trial females likely retained studies largely age associated non countries results sex gender variable relationship adolescent adult hypothetical hiv vaccine trials south africa appear modified high school student status addition studies discordant couples context hiv vaccine conducted examine gender roles inequalities preparation hiv vaccine trials
cases reported deformed geotextile reinforced soil walls cold regions deformation likely caused soil reinforced soil walls prevent deformation caused regional development ministry land infrastructure transport tourism established specific construction techniques however preventive measures specified geotextile reinforced soil service toward proposing countermeasures deformation full scale tests conducted results demonstrated application materials outer surface geotextile reinforced soil walls helps control deformation
fungal infections rare compared bacterial infections increase critical care units diagnosis difficult resulting increased mortality patients higher risk fungal infections including organ transplant oncology hiv aids patients fatigue fever common symptoms require critical care nurses remain assessment identify risk patients promote use timely cultures appropriate treatments fungal infections critical care nurses contribute decreasing risk fungal infections controlling glucose levels decreasing use invasive lines preventing unnecessary antibiotic use
sexuality integral part overall health impact neurological diseases sexual function still receives little attention aim case control study compare frequencies characteristics sexual dysfunction women stable relapsing remitting multiple sclerosis migraine sexually active women aged years recruited headache outpatient clinics university hospital asked complete questionnaires sexual function using multiple sclerosis sexuality questionnaire adapted patients migraine depression using beck depression inventory bdi quality life using short form questionnaire least one symptom sexual dysfunction almost always always present patients patients migraine total score differ two groups respectively sexual dysfunction categorized primary secondary tertiary patients migraine patients respectively depressive symptoms common women sexual dysfunction without migraine showed decreasing quality life increasing sum scores mental subscale physical subscale sexual dysfunction major problem women women migraine strongly associated comorbid depression impaired quality life thus sexuality done limited complex interactions
field nano technology first time microcontroller controlled high voltage power supply generator designed main purpose microcontroller driven generator design reduce unit cost increase precision efficiency using technology varying collector unit ultra thin aligned non aligned high voltage power supply takes low voltage input generates high voltage low current output mandatory stimulate emphasis paper elaborate details hardware software design generation technique control strategy motor movement design used designing high accuracy generators produce predominantly used field nano medicine agriculture textile industry
many real world applications like video demand web servers require prompt responses access requests however explosive increase data volume emerging faster higher power requirements energy consumption disk based storage systems become salient issue achieve energy conservation prompt responses simultaneously paper propose novel energy saving data placement strategy called based energy aware sea applied structured storage systems save energy providing quick responses implement two sea powered based data placement algorithms incorporating sea strategy respectively extensive experimental results demonstrate compared three known data placement algorithms greedy reduce mean response time average least saving energy average less respectively
simulation light flux density distribution receiver plays important role energy estimation design optimization field focusing strategy central receiver system however simulation time consuming procedure paper propose fast simulation method fully exploits tremendous rendering parallel computing capacities contemporary graphics processing units gpus first auxiliary spatial data structure employed organize field parallel light beam algorithm designed performed gpu determine blocking reference flux spot reflected receiver computed using model accumulated final flux density distribution computing stage accumulation stage accomplished via gpu rendering pipeline proposed method verified taking power plant example method considers blocking effects simulation results consistent official report due high efficiency proposed method potential applications design optimization elsevier ltd rights reserved
article presents microfluidic approach integration process selection via systematic evolution ligands exponential enrichment approach employs based biochemical reactions affinity selected target binding transferred amplification amplification product transferred back affinity selection via pressure driven fluid flow hybrid approach simplifies device design operation procedures reduced pressure driven flow control requirements avoids potentially deleterious exposure targets electric fields prior affinity selection addition based reactions used achieve chip coupling affinity selection amplification target binding thereby realizing chip loop closure integration entire process without requiring offline procedures microfluidic approach thus capable closed loop enrichment demonstrated selection dna protein immunoglobulin high affinity rapid manner rounds approximately
myeloproliferative neoplasms mpns common underlying disorder found patients vein thrombosis clinical risk factors mpn associated include younger age female sex concomitant disorders mutation risk factors distinct associated arterial deep venous thrombosis mpn patients suggesting disparate disease mechanisms pathophysiology thought derive local interactions activated blood cells unique endothelial environment mutations commonly found mpns including calr mpl rare mpn associated purpose article review clinical molecular risk factors mpn associated particular focus possible mechanisms formation mpn patients
purpose experimentally test whether chronic sleep restriction common among adolescents related poor learning behaviors diminished arousal classroom like situation methods sixteen healthy adolescents underwent sleep manipulation included order five consecutive sleep deprivation hours bed versus five healthy sleep duration hours bed end condition participants viewed educational films took related simulated classroom eight participants also underwent video electroencephalography monitoring assess levels behaviors arousal respectively results compared healthy sleep condition sleep deprived participants lower scores behaviors lower arousal conclusions pilot data complement previous correlational reports showing chronic sleep restriction adolescence cause diminished learning lowered arousal simulated classroom society adolescent health medicine rights reserved
gene associated interferon induced mortality targets multiple signaling pathways involved cell death growth however role pathogenesis hepatitis virus infections remains unexplored investigated restrictive effects replication hepatitis virus hcv found protein levels reduced hcv infected cells cells harboring hcv moreover expressed caused reduction intracellular viral rna levels secreted viruses infected cell cultures restrictive effect hcv replication restored treatment sirna interestingly overexpression alter level phosphorylated subcellular distribution strikingly forced expression attenuated increase intracellular lipid droplets acid treatment infection overexpression abrogated fatty acid induced upregulation regulatory element binding transcription factor resulting attenuated expression target genes fatty acid synthase fas acetyl coa acc treatment overexpression expressing infected cells restored hcv replication results suggest hcv replication attenuating intracellular lipid accumulation therefore anti viral host factor promising target hcv treatment
knowledge putative insect species vectors lethal disease crucial develop effective disease management plan specimens families collected provinces coastal region covering two main growing seasons sequence analyses rrna gene used clustering polymerase chain reaction pcr amplification performed employing three different primer sets specific blast sequence comparison phylogenetic analysis rdna pcr products revealed collected specimens carrying virtual rflp analyses obtained sequences confirmed assigning detected subgroup confirming related strains first detection related strain
work biosensor prepared determination acid dna based adsorption recognition function core oxide polymers dna polymers composed nanoparticles core polymers confirmed scanning electron microscope sem ray powder diffraction xrd fourier transform infrared ftir modified dna based principle complementary base introduced system selectivity sensitivity dna detection significantly improved adsorption properties dna researched adsorption equilibrium adsorption kinetic thermodynamics optimized conditions dna assayed linear concentration range mol detection limit mol relative standard deviation biosensor finally used determination dna laboratory samples ranged satisfactory results revealed potential application biosensor diagnosis treatment human genetic diseases elsevier rights reserved
shallow flows play significant role sediment management dam reservoirs sedimentation shallow reservoirs free flow flushing operation shallow flow emerges symmetric asymmetric patterns flow domain exhibits complex three dimensional features helical flows study focuses numerical modelling velocity field shallow reservoirs varying geometries also varying bed conditions flat beds fully numerical model using finite volume method utilised reproduce flow velocity field experimentally measured surface velocity cases velocity profiles one case used validate model numerical results showed slight disturbance inflow boundary condition results steady asymmetric flow pattern reservoirs higher defined shape factor affect flow pattern reservoirs lower defined shape factor nonetheless simulated measured flow velocity fields reasonably consistent cases results used optimise design sand water storage facilities also optimise sediment management existing reservoirs
prototyping trading strategies often reuse previously computed values full problems avoiding increase productivity built library function computations files avoid minimize need users think whether appropriate giving control speed accuracy space usage built automatic library modifying python distributed computing libraries library attempts maintain ease use libraries offering higher degree control carried allows control space usage individual functions specific function accuracy checking uses faster provides divide approach reuse previously computed show optimization french singular value decomposition using library greatly speeds often versus versus also show divide approach give large sorting published article government work public domain usa
often observed patients brain damage however evidence regarding relationship neuropsychological functions scarce addition previous studies proposed two possibilities relationship false memory patients likely retrieve false memories relatively independent false memories present study investigated related various cognitive functions including orientation attention frontal lobe function memory mental status false memories assessed deese roediger mcdermott drm paradigm patients organic participated evaluated using battery patients classified two groups patients group significantly impaired time orientation attention verbal memory compared group age matched healthy controls results drm paradigm revealed significant difference false memory retrieval induced critical lures across groups responses organic part induced disturbance time consciousness attention control severe impairment verbal memories false memory modulated different cognitive systems
dislocations uncommon representing similar traumatic dislocations present two cases closed medial dislocation systematic literature review last years performed embase medline pubmed cochrane search literature written english january december keywords used sub dislocation dislocations articles presenting original patient data included available data regarding gender age direction affected side open closed injury accompanying fractures reduction time immobilization outcomes collected database seventy six articles included total reported cases males right foot affected often females left foot average age years range months years cause injury traffic accident fall sports injuries injuries causes direction dislocation medial lateral posterior anterior open dislocation reported additional injury diagnosed closed reduction unsuccessful requiring immediate open reduction overall outcomes literature good fair poor
introduction treatment children clinically aggressive high risk neuroblastoma remains challenging less patients high risk neuroblastoma survive long term current therapies survivors risk serious treatment related late toxicities review new evolving treatments ultimately improve outcome children high risk neuroblastoma decreased potential late adverse covered new strategies treating high risk neuroblastoma reviewed including radiotherapy targeted biologics immunotherapy molecularly targeted agents recently completed ongoing neuroblastoma clinical trials testing novel treatments highlighted addition discuss ongoing clinical trials designed evaluate precision medicine approaches target somatic mutations oncogenic cellular opinion advances genomic medicine molecular biology led development early phase studies testing biologically rational therapies targeting activated cellular pathways many drugs wider therapeutic index standard agents treatments effective less toxic current strategies however effectively integrate targeted strategies robust predictive biomarkers developed identify patients benefit approaches rapidly match treatments patients diagnosis
allergic common persistent childhood asthma thorough assessment allergy crucial optimal care children microarray testing offers opportunities improved characterization projected useful management patients objectivethe aim study investigate accuracy information obtained two microarray platforms applied characterized pediatric asthma cohort one children recruited nationwide swedish study severe childhood asthma severe controlled assessed allergic sensitization two microarray systems two standard diagnostic methods skin prick test data clinical history physical examination asthma control test doctors diagnosis collected results four diagnostic methods analyzed compared resultsa high prevalence allergic sensitization observed cohort pairwise concordance two methods independently methods compared sensitivity four methods doctors diagnosis specificity microarray methods provided new information sensitized children comparison results obtained standard diagnostic methods conclusionthe high prevalence food respiratory sensitization supports clinical guideline recommendation allergies evaluated children suspected asthma microarray platforms studied demonstrated acceptable accuracy provided refined ige characterization patients compared standard extract based methods
fundamental purpose sleep remains one compelling questions yet answered area neuroscience biology pervasive behavior among members animal kingdom functional necessity engaging regularly sleep best demonstrated showing failing leads broad repertoire pathological outcomes including cognitive immunological hormonal metabolic outcomes among others indeed absolute requirement sleep shown studies demonstrated continuous total deprivation sleep short period days generally lethal species common clinical sleep disorder insomnia principal disease primary insomnia morbidity large number unrelated diseases including chronic pain attention deficit hyperactivity disorder depression treatment perspective restoring normal healthy sleep delivers subsequent benefits cognitive function mood potential beneficial therapeutic impact daily functioning across multiple diseases healthy sleep compromised remarkable escalation understanding anatomy physiology sleep wake control mechanisms provides new opportunities modify neurobiology sleep wake related behaviors novel exciting ways parallel expansion sleep research novel interfaces sleep wake biology disease states revealing additional extensive implications lost sleep current conventional pharmacological approaches treatment sleep wake disorders discussed based mechanism action within cns effect sleep wake review recent sleep biology sleep pharmacology peers future sleep therapeutics highlight mechanistic safety functional outcomes key differentiating establishing success next generation arousal modifying therapeutics
using baseline data randomized controlled pediatric obesity prevention trial study sought examine general parenting style potential moderator association feeding specific parenting practices child dietary intake four hundred twenty one parent child dyads served participants girls mothers children average years old either overweight risk overweight mean bmi percentile data collected participants homes study staff measured childrens height weight parents completed questionnaires designed assess general parenting styles permissive child feeding practices restriction monitoring child dietary intake assessed using recall system outcomes daily fruits vegetables sugar unhealthy results follows permissive parenting inversely associated fruit vegetable consumption parental monitoring inversely associated consumption main effects parenting style feeding practice child dietary consumption parenting moderated association restriction intake marginally significant effect correcting multiple comparisons restriction inversely associated consumption high consumption low findings indicate parenting practice monitoring child dietary intake associated consumption regardless parenting style interventions thus benefit encouraging parental monitoring parenting strategy restricting child dietary intake contrast associated lower intake context higher parental context lower parental exploratory finding warrants investigation elsevier ltd rights reserved
spreading cause cortical electrical potential changes wide spectral range includes slow potentials approaching direct current level negative direct current shift important identifier cortical depolarization duration measure potential tissue injury associated longer lasting determine feasibility monitoring full signal bandwidth spreading patients performed using platinum electrode strips direct current coupled amplifiers patients acute brain injury two centers large baseline direct current developed loss data due amplifier saturation minimal rates baseline drift throughout recordings generally low transient negative direct current shifts spreading easily recognized cases measurable characteristics following standardized training session novice achieved high degree accuracy reliability identifying suggesting direct current coupled recordings facilitate diagnosis future trials clinical decision making conclude intracranial monitoring slow potentials achieved platinum electrodes direct current coupled recordings advantageous identifying assessing impact spreading
performing electron tomography tilt series images often acquired samples contain unwanted material embedding resin thin carbon support film hydrocarbon contamination presence layers introduce reconstructions features interest illustrate benefit preprocessing high angle dark field tilt series unwanted low using simple intensity procedure resulting fewer segmentation performed accurately present two representative examples taken studies catalyst nanoparticles amyloid plaque core material human brain
androgen replacement therapy male hypogonadism prescribed utilizing oral recently topical formulations topical formulations risk person person transmission appropriate taken describe two cases pre children following passive transfer paternal topical testosterone month old male referred week history hair growth linear growth genital examination revealed stage hair stage development discordant pre testicular size bilaterally year month old girl referred month history increasing hair development examination revealed stage hair stage breast development patients fathers diagnosed hypogonadism treated topical androgen gel therapy applied arms chest bed addition patients often parents resulting skin skin contact investigations consistent independent patients demonstrating elevated testosterone levels testosterone levels returned normal pre levels development secondary sexual characteristics following discontinuation exposure topical testosterone taken prevent person person transfer topical steroids increasing popularity topical steroids treatment low testosterone imperative therapies prescribed utilized prevent harm specifically independent
introduction current small pilot naturalistic cross sectional study assesses whether higher dosages anti related satisfactory outcome concerning symptoms schizophrenia also worse outcome terms adverse events neurocognitive function material methods male stabilized hospitalized patients assessed depression rating scale scale battery neurocognitive tests medication dosage prescribed according clinical therapist results clinical variables adverse events differ patients recommended high dosage groups higher dosage correlated depressive symptoms correlation neurocognitive measures except impaired concentration discussion results suggest possible achieve good clinical response refractory exceeding recommended antipsychotic dosages price depression possible mild isolated concentration deficits neurocognitive adverse events currently clinicians prefer first generation antipsychotics high dosages prescribed considering favorable adverse effects profile newer agents important study higher dosages agents test whether given high dosages necessary published elsevier inc
patients antisocial personality disorder outpatient treatment substance use disorders high risk drop using randomized design study tested impact adding brief psycho educational program impulsive lifestyle counseling program outpatient substance abuse treatment order prevent treatment dropout patients recruited municipal treatment centers denmark assigned treatment usual experimental condition patients included analyses intent treat analysis risk treatment dropout reduced among patients randomized experimental program hazard ratio controlling age gender substitution treatment status study supported efficacy impulsive lifestyle counseling program method preventing treatment dropout patients comorbid antisocial personality disorder substance abuse treatment trial registration elsevier ltd rights reserved
objective ulipristal acetate upa safe effective emergency contraception prospective open label exploratory study conducted obtain additional data pharmacodynamic effects repeated dose upa week period effects ovulation inhibition hormonal levels cervical safety tolerability data repeated use upa also collected study design total healthy female healthy women participated two receiving upa consecutive weeks upa administered every days every days subjects monitored three times week baseline cycle treatment hormonal measurements cervical evaluation laboratory safety measurements standard surrogate thrombosis risk markers measured baseline within days last tablet phase endometrial biopsy taken baseline cycle posttreatment results total subjects least respectively similar normal hormonal profiles effect cervical observed biopsies classified benign biopsies posttreatment classified typical progesterone receptor modulator associated endometrial changes upa tolerated treatment arms clinical laboratory results surrogate thrombosis markers conclusions repeat use oral upa every days weeks initially delays follicular rupture ovulation eventually occurs time subjects safety data indicate upa safely administered needed given menstrual cycle elsevier inc rights reserved
paper presents elastic transactions appealing alternative traditional transactions particular implement search structures shared memory multicore architectures upon conflict detection elastic transaction drop far within separate transaction immediately computation within new transaction elastic present elastic transaction model implementation illustrate simplicity performance various concurrent data structures namely double ended hash table linked list list elastic transactions outperform classical ones various workloads improvement average also exhibit competitive performance compared lock based techniques much simpler program lock free alternatives elsevier inc rights reserved
rising air water pollution become issues widespread public concern india relationship spatial distribution environmental pollution social disadvantage received less attention lack attention becomes particularly relevant context industrial pollution india continues pursue industrial development policies without sufficient regard adverse social impacts letter examines industrial pollution india environmental justice perspective presenting national scale study social distribution industrial hazardous waste generation analysis district level data national inventory hazardous waste generating industries variables representing urbanization social disadvantage socioeconomic status census india results indicate districts higher proportion socially economically disadvantaged residents significantly likely generate hazardous waste quantity hazardous waste generated significantly higher districts higher proportion economically disadvantaged households accounting relevant explanatory factors literacy social disadvantage findings underscore growing need incorporate considerations future industrial development waste management india
examine differential effects mental pain suicidal tendencies female victims sexually physically abused sexual abuse victims report mental pain suicidal tendencies physical abuse victims group women completed questionnaires measured mental pain suicidal tendencies thoughts demographic details sexual abuse victims suffered mental pain physical abuse victims physical abuse victims demonstrated life sexual abuse victims sexual abuse victims demonstrated less attraction life physical abuse victims showed attraction death
international league dermatological societies global profit organization representing dermatological societies worldwide identified consequences skin aging one important challenges global skin health reduced functional capacity increased susceptibility skin development dry skin ulcers fungal infections benign malignant tumors common skin conditions aged populations worldwide environmental pollution lifestyle factors smoking use negatively affect skin health turn altered appearance dry skin chronic wounds conditions decrease general health reduce likelihood healthy active aging preventive skin care includes primary secondary tertiary interventions continuous sun protection early childhood important avoid extrinsic skin damage skin cancer exposure allergens molecules damaging skin avoided reduced minimum public health approaches needed implement preventive basic skin care worldwide reach high numbers dermatological patients care receivers education primary caregivers implementation community dermatology successful strategies resource poor countries besides specialist physicians nurses health care professionals play important roles preventing managing age related skin conditions developing developed countries healthy skin across life course leads better mental emotional health positive impact social engagement healthier active productive lives
electrical energy normally generated different sources wind heat nuclear transformation chemical reactions vibrations nowadays harvesting power mechanical vibration one novel technologies usually done systems based electromagnetic electrostatic piezoelectric combination piezoelectric systems convert motion structures electrical power cellulose electro active paper recognized novel smart piezoelectric material used energy harvesting purposes one prevalent method vibration energy harvesting using piezoelectric cantilever beams paper analytical solution based distributed parameter model presented calculate generated energy vibration cantilever substrate partially covered material studied structure piezoelectric layer thickness comparison length beam thickness substrate material considered thin thus effect vibration behavior structure negligible results validated experimental values analytical data found close experimental results finite element simulation values findings study provide guidelines system parameters manipulated efficient performance different ambient source conditions
cyclin dependent kinase family member global neuronal cytoskeletal dynamics indispensable brain development adults essential numerous neuronal processes including higher cognitive functions learning memory formation drug addiction pain signaling long term behavior changes long term long term depression rely rapid alterations cytoskeleton activity becomes deregulated various brain disorders including alzheimers disease parkinsons disease disease attention deficit hyperactivity disorder epilepsy schizophrenia ischemic stroke result profound remodeling neuronal cytoskeleton commentary specifically focuses pleiotropic contribution regulating neuronal microtubule remodeling vast majority physiological substrates associated neuronal cytoskeleton emphasis substrates tau allowed unravel molecular mechanisms exerts divergent roles regulating neuronal microtubule dynamics healthy disease states
century systems biology holistic approach understand life cross talk study genome proteome cell describe column based rapid method simultaneous extraction dna rna mirna microrna proteins experimental sample without prior allows direct correlation genomic transcriptomic proteomic data method provides simple effective way analyse biomolecules without affecting yield quality also show isolated biomolecules highest purity compatible respective downstream applications pcr amplification pcr reverse transcription pcr real time pcr reverse northern blotting sds page western blot analysis reagents used method optimized extensively achieve cost effective reliable procedure separate functional biomolecules cell
introduction hereditary angioedema inhibitor deficiency inh hae rare disease characterized recurrent unpredictable episodes cutaneous mucosal edema bradykinin released activation contact system binds bradykinin receptors endothelial cell surface enhance vascular leads covered inh hae therapy aimed inhibition bradykinin release effects mediated receptor three controlled trials three open label extensions two open label studies prospective observational study confirmed safety efficacy bradykinin receptor antagonist administered acute treatment hae attacks adult patients inh commentary ready use pre filled self administered easily effectively safely importantly resulted patients able quickly treat attack realize dramatic change better lives
genus causes significant economic losses due infertility abortion weak neonatal mortality livestock still public health importance worldwide study aimed optimize evaluate pcr assays used diagnosis infections aim several primers pcr protocols performed compared cultures biological material inoculated pcr assays genus species specific oligonucleotide primers derived rrna sequences used primers except detected dna reference strains field isolates spiked blood milk samples primer oriented pcr assays detected minimal numbers spiked serum fetal stomach content primer oriented pcr assays detected minimal numbers field samples collected sheep cattle examined methods optimized pcr assays overall sensitivity pcr assays found superior conventional isolation dna detected fetus blood milk serum samples pcr assays respectively conclusion pcr assay optimized conditions found valuable sensitive specific detection infections animals
two studies examine relationship naturally occurring levels circulating testosterone empathic accuracy study authors find higher endogenous levels testosterone negatively related accuracy people infer thoughts feelings others study authors use data collected field show individuals higher levels endogenous testosterone evaluated real world professional colleagues functioning lower levels empathic accuracy furthermore authors report evidence negative relationship testosterone perceived empathic accuracy downstream consequences perceptions ones leadership skills abilities
letter discusses failure lorentz force law locate action force law makes predictions agree experiment
using ray scattering investigate liquid spanning wide temperature range near melt demonstrate density anomaly fragile strong transition related short range order structural change like distortion also accompanied remarkable development medium range order latter manifests emerging pre peak total structure factor atomic pair correlations length scale similar real space function results highlight role medium range structural ordering evolution entropy according gibbs theory linked fragile strong transition transition based relation structure liquid dynamics transitions high pressures examined terms experimental data relation work identifies length scale atomic correlations structural presents structural approach exploring liquid dynamics useful investigating relevant phase change alloys inc published elsevier ltd rights reserved
psychiatry emergence large multi center population imaging studies raises numerous technological challenges distributed data collection across different institutions countries final data publication service one handle massive heterogeneous complex data genetics imaging demographics clinical scores data efficiently obtained present python solution based open source semantic framework aimed building population imaging study repositories addition focus tools developed around framework overcome challenges associated data sharing collaborative requirements describe set three highly adaptive web services transform framework multi center platform collaborative quality assessment platform publication platform massive capabilities two major european projects aims currently supported described framework also present python package enables end users remotely query neuroimaging genetics clinical data scripts
effective drug treatment relapsing remitting multiple sclerosis patients discontinuation mandatory due risk progressive however severe clinical radiological worsening described drug cessation aim describe clinical radiological features phenomenon material switched presented discontinuation selected clinical magnetic resonance imaging mri data collected virus positive patients included mean disease duration mean time patients started within neurological deterioration started mean time involvement motor disturbances cognitive impairment seizures average worsening expanded disability status scale points mri showed large increase enhanced lesions mean patients received one patient required plasma exchange patients presented neurological deterioration worsening points three patients continued treatment one patient treatment trigger severe marked clinical radiological worsening careful evaluation benefit risk considered withdrawal close monitoring short period recommended drug withdrawal
background little known regarding relationships among circulating brain derived neurotrophic factor bdnf levels glucose insulin children adolescents objective study investigate whether circulating bdnf levels change oral glucose tolerance test methods performed measured serial changes bdnf levels plasma serum results subjects normal type group borderline diabetic type group defined results serum levels bdnf almost five times higher plasma levels gradually decreased whereas serum levels showed significant change reduction plasma bdnf level changes baseline min significantly different groups conclusions results showed plasma levels bdnf sensitive acute changes glucose insulin levels serum
increasing incidence dementia aging population consequently urgent need develop treatments activities alleviate symptoms dementia accumulating evidence shows persons dementia music ability respond music potentially preserved even late severe stages dementia verbal communication media interest topic contributed public perception music abilities island preservation otherwise cognitively impaired person dementia chapter review current literature music cognition dementia show scarce rigorous scientific investigation issue various types music memory exist differentially impaired different types dementia furthermore discuss recent development music activities treatment dementia highlight methodological limitations current literature topic reported music activities improve behavior particularly mood cognition persons dementia recent large scale randomized control studies questioned specificity effect music found beneficial activities nevertheless music unique powerful ability elicit memories emotions provide important link individuals past means nonverbal communication make ideal stimulus persons dementia
combat sport high risk injury present rare case traumatic left posterior joint dislocation year old boy extensive literature review reveal case posterior joint dislocation patient treated closed reduction general anesthesia year follow left upper extremity full range motion residual symptoms decided training however participates physically demanding sports although often encountered posterior joint dislocation challenging critical medical problem fatal diagnosed treated time considered differential diagnosis trauma related anterior chest pain
arterial wall composite preferred orientation collagen fibers induces anisotropy though theories fiber reinforced composites reached high level showed reasonable correspondence available experimental data short failure description following tradition strength materials failure criteria usually separated stress analysis present work incorporate failure description models soft anisotropic materials introducing energy strain energy functions provide saturation value strain energy indicates maximum energy stored material volume using popular constitutive models enhanced energy analyze rupture sheet arterial material plane stress state varying equal tension calculate local failure criteria including maximum principal stress maximum principal von stress strain energy moment sheet rupture find local failure criterion form critical strain energy robust among considered ones also find tensile strength maximum principal stress usually obtained tension tests appropriate failure indicator cases developed stress strain state elsevier ltd rights reserved
genetic rare group disorders leading progressive degeneration cerebral white matter associated spectrum clinical phenotypes dominated dementia psychiatric changes movement disorders upper motor neuron signs mutations least genes lead often overlapping clinical radiological presentations reasons patients genetic often long diagnostic receiving definitive diagnosis receive diagnosis study used focused whole exome sequencing evaluate cohort adult patients referred specialist service total patients evaluated using focused exome sequencing genes detected pathogenic likely pathogenic variants cases frequently mutated genes carried whole exome sequencing remaining negative cases including four family identify potentially disease causing mutations confirming equivalence focused whole exome sequencing diagnosis genetic provide overview clinical genetic features disorders adults
psychological treatment choice obsessive compulsive disorder exposure response prevention erp however training required practitioners delivering erp readily available thereby rendering treatment patients self directed erp programs designed increase accessibility erp proven effective perhaps patients find difficult comply exposure exercises without guidance clinician research cognitive bias modification suggests help individuals approach situations case study patient completed week treatment program combines treatment led significant decrease symptoms functional impairment results suggest novel treatment requires initial couple sessions clinician trained erp potential increase accessibility erp patients wiley periodicals inc
wood promotes habitat heterogeneity influence flow hydraulics channel within columbia river basin usa wood vital creation maintenance habitat threatened however understanding relative roles climatic ecological processes source wood streams limited making difficult identify baseline predictions wood create targets stream restoration investigate wood frequency volume differ seven sub basins interior columbia river basin processes shape differences within sub basins collected data wood volume frequency discharge stream power watershed forest structure use modelling wood volume frequency using random forest models found mean annual precipitation tree cover individual watershed important predictors wood volume frequency within sub basins used linear models finding basins unique predictors wood discharge watershed area precipitation often combined forest cover large tree cover models large wood volume frequency many sub basins models showed least one hydrologic variable indicative transport competence one ecological variable indicative reach upstream watersheds capability grow measurable wood conclude basin specific models yield important insights hydrologic ecological processes influence wood loads creating hypotheses building predictive models wood copyright john wiley sons ltd
species highly destructive associated massive damage natural ecosystems agriculture production also affected mainly causes root two widely used pose resistance susceptible interaction respectively makes suitable models study plant defense mechanisms gene expression analysis important tool type study particular pcr qpcr hence crucial use appropriate reference genes expression normalization aim evaluate stability several candidate reference genes determine set best suited normalization infected evaluated five candidate reference genes selected database algorithms used assess best reference genes found stable genes used qpcr analysis plants box suitable four genes found excellent stable throughout infection regardless pathogen attack symptom development
background incidence lower extremity injuries female soccer players high risk factors injuries unknown purpose investigate risk factors lower extremity injuries elite female soccer players study design cohort study level evidence methods players norwegian elite female soccer league teams participated baseline screening tests competitive soccer season screening included tests assessing maximal lower extremity strength dynamic balance knee angles drop jump landing knee joint generalized joint foot also included questionnaire collect information demographic data elite level experience injury history time loss injuries exposure training matches recorded prospectively subsequent soccer season using weekly text messaging players reporting injury contacted collect data regarding injury circumstances univariate multivariate regression analyses used calculate odds ratios ors confidence intervals cis standard deviation change results total players underwent complete screening tests registration injuries exposure throughout season total injuries players recorded ligament muscle injuries frequent multivariate analyses showed greater body mass index bmi factor significantly associated new lower extremity injuries greater bmi associated new injuries lower knee angle drop jump landing associated new ankle injuries previous knee injury associated new lower leg foot injuries whereas none factors investigated influenced risk new knee injuries conclusion greater bmi associated lower extremity injuries elite female soccer players clinical relevance increased knowledge risk factors lower extremity injuries enables targeted prevention strategies aim reducing injury rates female soccer players
islands clusters central macrophage supports development maturation red blood cell erythroid progenitors clusters play crucial roles pathogenesis observed animal models hematological disorders precise structure function islands poorly understood combined scanning electron microscopy immuno gold labeling surface proteins develop better understanding clusters erythroid specific surface antigen receptor exhibited distinct patterns protein sorting erythroid cell maturation detected immuno gold labeling electron microscopy analysis observed two distinct classes islands islands varied size morphology number type erythroid cells interacting central macrophage assessment femoral marrow isolated rodent species guinea pig species fat showed morphology central macrophage varied two different types islands consistently findings suggest two classes islands conserved mammalian evolution play distinct roles red blood cell production
background past research underscores key role coping strategies development maintenance exacerbation posttraumatic stress disorder ptsd symptoms goal current study extend existing literature examining whether race ethnicity relations among coping strategies social support problem solving avoidance ptsd symptom clusters intrusion avoidance arousal methods participants community women african americans whites reported bidirectional aggression current male partner path analysis utilized test moderating role race ethnicity model linking coping strategies ptsd symptom strength direction relations among coping strategies ptsd symptom clusters varied function race ethnicity greater social support coping related arousal symptoms whites greater problem solving coping related fewer arousal symptoms greater avoidance coping related symptoms across many ptsd clusters african americans whites however relations strongest african results provide support moderating role race ethnicity relations among coping strategies ptsd symptom clusters highlight potential targets culturally informed ptsd treatments
introduction growing knowledge wide ranging effects histamine throughout body therefore important better understand effects amine patients asthma aimed explore association histamine pharmacodynamic response genetic variation histamine pathway children asthma methods histamine laser doppler monitoring performed children asthma estimates area effect curve maximal response baseline time calculated using non analysis non linear mixed effects model linked effect model dna isolation genotyping performed among participants detect known single nucleotide polymorphisms snps among genes within histamine pathway general linear model used identify associations histamine related genetic variants measured histamine response parameters results genotyping response profiles completed children associated genotype mean genotype mean genotype mean genotype mean genotype mean genotype mean stratified analysis among african american children snps also associated response genotype associated lower conclusions show first time histamine pathway genetic variation associated changes histamine response children asthma variability histamine response impact histamine pathway genotype important explore patients asthma improve disease leading personalized treatments
paper fractional derivatives sense modified riemann derivative function method expansion method generalized method used construct exact solutions dimensional space time fractional modified equation fractional equation turned another nonlinear ordinary differential equation fractional complex transformation three methods applied solve result new exact solutions obtained three methods demonstrate power reliability efficiency elsevier ltd rights reserved
present case woman bipolar disorder severe mood instability confusion psychosis resembling clinical features postpartum psychosis estrogen levels expected low estrogen levels expected elevated depressive symptoms across menstrual cycle extensively documented literature little information regarding manic symptoms addition describe successful treatment menstrual cycle related symptoms approaches management menstrual psychosis systematically studied clinical guidelines exist clinical experiences one reported clinical formulation patient consistent known neuroendocrine phenomena treatment approach successful crucial developing promising approaches tested controlled trials
like many development established situated demographic geographic margins state border region historically major center population particularly moments cross border violence becomes central margin place crucial israeli nation reason inhabitants others often strong qualities said center time like development residents mainly marginal regions constitute majority israeli population also many constitute class vis vis historically elite development thus marginal center power vulnerable insecurity poverty associated crucial bounded israeli nation article demonstrates move margins exclusion center inclusion calling upon nation connections everyday life marked boundaries differentiated others thus reinforcing logic israeli historically margins state
article contributes development professional discourses recording technologies ethnographic research synthesizing scholarship ethnographic sound multimedia technologies article applies concepts transduction analyze part encounters based comprised people living hiv south africa discuss research participants guided use inequality hiv stigma analyze ethical communicative recording technologies examining design audio video technologies cultural communicative use evaluation use technologies analysis suggests ethical communicative transducers yield extension social self self ways
parasitic major threat productivity throughout west central africa identification sources resistance incorporation breeding programs beneficial strategy combat caused parasite fields study examined one hundred ninety four four commercial varieties two controls collected mini core collection held international institute tropical agriculture resistance race prevalent race nigeria using phenotypic screening molecular marker analysis studies identified two resistant resistance lines associated molecular marker known gene resistance cultivar resistance expressed response site infection roots tests indicated gene resistance independent resistance provide additional new sources resistance prevalent nigeria
autoimmune regulator essential perinatal period prevent autoimmunity show regulated single positive trafficking neonatal period critical reduced found mice neonatal period leading enhanced homeostatic expansion peripheral cells early weeks age neonatal mice expression ligands dramatically reduced resulting decreased motility reduction mice alleviated beyond weeks age early upregulation signaling numbers quality essential establishment maintenance peripheral tolerance reduced neonatal period autoimmunity caused cells
systems used advantage last years distributed electricity generation systems function growth natural gas pipeline network distribution system incentives energy regulation policies typically system used produce electrical power simultaneously supplying heating cooling load recovering combustion products thermal power content otherwise driven atmosphere concerning two small scale plants tested overall efficiency evaluation operational comparison first system based iso natural gas powered second one uses natural gas powered internal combustion engine coupled electrical generator prime stack gases machines directed ammonia water absorption refrigeration producing water first next water heat recovery order produce hot water experimental results presented along relevant system operational parameters appropriate operation including natural gas consumption net electrical thermal power production hot cold water production rates primary energy saving index energy utilization factor total partial electrical load operational conditions elsevier ltd rights reserved
patients diabetes mellitus exhibit increased risk development heart failure occurrence heart failure patients diabetes associated poor prognosis therapeutic strategies reduce cardiovascular morbidity mortality diabetes far mainly focused prevention coronary events recent data suggest early diagnosis heart failure diabetes specific therapies major impact prognosis patients article aims provide comprehensive overview epidemiology pathophysiology prognosis heart failure diabetes patients addresses current aspects heart failure therapy diabetes diabetes therapy heart failure patients
travelling time central feature episodic memory severely affected among individuals post traumatic stress disorder ptsd two opposite effects traumatic memories bottom processes non traumatic personal memories tend lack spatio temporal details false occur frequently general population top processes test effect two types processes bottom top emotional memory conducted two studies healthy adolescents period life vulnerability emotion particularly high using negative neutral images selected international affective picture system stimuli divided perceptual images emotion generated perceptual details conceptual images emotion generated general meaning material categories stimuli used along neutral pictures memory task two phases encoding recognition populations reported differential effect emotional material encoding recognition negative perceptual scenes induced attentional capture effect encoding enhanced conversely encoding conceptual scenes similar neutral ones conceptual relatedness induced false memories retrieval however among individuals ptsd two subgroups patients identified first subgroup processed scenes faster controls except perceptual scenes obtained similar performances controls recognition task second subgroup group attentional deficit encoding task benefit associated negative perceptual scenes memory performances findings provide new perspective negative emotional information opposite influences memory normal individuals also gives clues understand intrusive memories takes place ptsd elsevier ltd rights reserved
scientific applications become data intensive finding efficient scheduling strategy massive computing network based computing systems drawn increasingly attention existing scheduling models assume processors beginning workload assignment fact real distributed computing environments processors still occupied previous assigned workload new load time period states processor referred release time based fact processors arbitrary release times propose new load scheduling model hybrid time constraints design effective global optimization genetic algorithm solve finally experiment results show effectiveness efficiency proposed algorithm
ability automatically recognize human faces based dynamic facial images important security surveillance health independent living domains specific applications include access control secure environments identification individuals particular place detection research proposes real time system surveillance using cameras process broken two steps face detection face recognition identify particular persons first step system tracks faces detected persons efficient recognition algorithm used recognize detected faces known database proposed approach exploits method face detection algorithm feature tracker principal component analysis pca face recognition system implemented different restricted areas office house person entrance sensitive installation system works almost perfectly reasonable lighting conditions image depths
recent advances thermoelectric technology made exhaust based thermoelectric generators promising recovery waste heat utilization exhaust based heavy duty vehicles studied work given generated power limited still indispensable improve fuel economy generated electricity integrated automotive electrical system consumed electrical loads therefore two feasible ways integrating generated electricity automotive electrical system discussed one original works certain conditions strategy another smaller adopted works together cooperative work strategy overall performance efficiency obtained simulation analysis simulation results show methods improve fuel economy former provides better results moreover electrical loads properly modified fuel economy improved simulation results lay solid foundation application vehicles future
order obtain ideal material using artificial corneal porous polymer hydrogel containing butyl prepared one step radical polymerization method usage physical chemical properties fabricated polymer hydrogel adjusted content pore size porosity water content materials surface topography series cell biology experiments human corneal fibroblasts carried evaluate properties artificial corneal adhesion cells materials different pore size porosity apoptosis materials different characteristics distribution cells material surface results revealed high porosity improve water content hydrogel also strengthen adhesion hydrogel addition high porosity hydrogel shape pores showed much spindle like morphology low porosity mtt assay certified resulted polymer hydrogel material possessed excellent biocompatibility suitable growing making promising developed artificial corneal elsevier rights reserved
methods used analyze slope stability commonly based limit equilibrium theory expressed terms factor safety however analysis approaches variability soil parameters model uncertainties becomes necessary paper pre designed reinforcement slope available technical literature chosen probabilistic analysis statistic information parameters found literature numerical simulations done software slope besides parametric analysis done varying coefficient variability unit weight friction angle investigate effect variability reliability slope also contribution water level measured results show relevant variation reliability index parametric analysis indicating importance study furthermore water level decisive impact safety reliability slope lastly reinforcement geotextiles efficient increase safety slopes
whether exposure violence virtual reality media impact users aggressive behaviour controversial issue academic public debate article programme research conducted adolescents germany presents cross sectional longitudinal evidence association violent media use aggression provides experimental evidence support mediating variables hostile style increased normative acceptance aggression emotional explain pathways media violence use aggression addition presents development experimental evaluation theory based intervention designed reduce media violence use decrease link aggressive behaviour findings discussed context large international body research points causal role violent media use risk factor aggressive behaviour
neighborhood environments related parenting behaviors turn life long effect childrens health activity spaces measure individual routine patterns movement helpful assessing physical social environments shape parenting study use qualitative data gis mapping four california cities examine parental activity spaces parents described number factors shape activity spaces including caregiving status age children income parental activity spaces also varied times places adult child specific places knowing best capture study parental activity spaces identify mechanisms environmental factors influence parenting behaviors child health
methotrexate efficacious induction maintenance remission crohns disease goal pilot study determine whether total individual methotrexate glutamate levels red blood cells correlate disease activity adverse events crohns disease cross sectional study undertaken patients stable dose weekly methotrexate oral subcutaneous clinical disease activity assessed index biologic disease activity measured inflammatory markers concentrations individual levels measured red blood cells using high performance liquid chromatography mass spectrometry association observed individual total methotrexate glutamate concentrations clinical disease activity score inflammatory markers adverse events although crohns disease patients remission appeared generally higher total longer chain methotrexate concentrations compared active disease definitive association levels clinical disease activity established larger longitudinal studies patients diverse disease activity needed establish value levels indicators treatment efficacy clinical outcome
big data growing remarkably technological development field business growing trend try find useful information marketing activities enormous data however data analysis needs knowledge data structures programming skills difficult general employees acquire study propose system relation goods using point sales data ids think pre skills programming understand relation goods using proposal system easily proposal system turns web application able share result analysis using web becomes clear proposal system effective result interview evaluation
receptor seem play major role differentiation cells cells induction production activation inflammatory pathways recent studies suggested association polymorphisms bone articular inflammation diseases ankylosing spondylitis rheumatoid arthritis aim study determine association polymorphisms juvenile idiopathic arthritis case control study patients healthy controls performed samples genotyped eight single nucleotide polymorphisms snps using real time polymerase chain reaction taqman genotyping technique forty two patients healthy controls chosen randomly measure level serum using enzyme linked immunosorbent assay heterozygous genotype showed weak statistically significant protective effect subtype none selected snps associated overall indeed analysis haplotypes show significant association serum level significantly different among patients healthy controls subtypes moreover significant correlation snps serum concentration first study gene iranian patients results show strong association polymorphisms disease serum levels association seen larger studies help clarify role pathway pathogenesis
excessive traffic urban environments detrimental effects health economy standard living mitigate problem adaptive traffic signalling scheme developed tested paper scheme based state space representation traffic dynamics controlled via dynamic programme minimise implementation costs one loop detector assumed link comparative advantages proposed system optimal fixed time control highlighted example results demonstrate flexibility system applied different junctions monte carlo runs developed scheme highlight consistency repeatability results authors published elsevier
background bright light therapy influences regulation melatonin established treatment seasonal affective disorder sad study designed examine efficacy seizure control adults focal epilepsy design adults medically intractable focal epilepsy recruited parallel design double blind randomized trial add treatment epilepsy methods patients monitored seizure frequency home week baseline period september december participants allocated high intensity light box emitting using automated block randomization grid allocated identical box emitting low intensity dose patient populations groups instructed use box min upon every day weeks january march primary outcome measure trial seizure frequency results participants high intensity low intensity completed trial returned adequate data analyses median reduction seizures treatment phase group group patients high intensity condition experienced overall reduction frequency complex partial seizures compared patients used low intensity light box response rates treatment conditions significantly different patients hippocampal sclerosis likely respond either intensity patients focal risk ratio lower limit upper limit conclusions find significant difference rates low high intensity arms trial patterns within data suggest warrant investigation treatment people hippocampal pathology initial findings suggest caution using people extra temporal focal epilepsy result increase seizures elsevier inc rights reserved
similarly computer operating systems guarantee safe access memory resources network operating systems applications reliable access organized flow table resources paper presents architecture controller memory management system functionalities aim improving flow table usage preventing network implementation perspective work discusses applicability proposed system strategy evaluate current open challenges
paper results layout design circuit topological computer simulation elements analytical chip silicon structures presented elements input cascade basic element operational amplifier ring oscillator based standard bulk cmos technology cmos technology structures also resistive elements studied wide temperature range elements used regular elements matrix analog digital signal processing integrated circuits initial processing analytical information chip sensitive elements intellectual sensors chip
protein secondary structure describe protein construction terms regular spatial shapes including alpha beta loops protein amino acid chain adopt regions information supportive protein classification functional annotation structure prediction relevance information scope practical applications cause requirement effective storage processing relational databases widely used commercial systems recent years one serious alternatives years experience enriched developed technologies equipped declarative sql query language accepted large community programmers unfortunately relational database management systems designed efficient storage processing biological data protein secondary structures paper present new search method implemented search engine pss sql language pss sql allows formulation queries relational database order find proteins secondary structures similar structural pattern specified user paper show search process accelerated multiple scanning segment index parallel implementation alignment procedure using multiple threads working multiple core cpus
video games pervasive among children adolescents growing popularity video games debate among parents researchers video game producers policymakers concerning potential harmful helpful effects video games children article provides overview research findings positive negative effects video games thus providing empirical answer question video games good bad article also provides guidelines help pediatricians parents caregivers protect children negative effects maximize positive effects video games
objective clinicians ability infer patients thoughts feelings critical component high quality care goal article present new test measure ability clinicians called test accurate perception patients affect methods clips taken patients actual medical visits patients reviewed visit identify thoughts feelings visit information used extract short clips correct answer patients report thought feeling associated contains clips responded multiple choice format results showed good psychometric properties optimal mean good variance adequate internal consistency strong test reliability convergent validity tests emotion recognition addition test showed predicted better performance female male participants conclusion promises valuable tool research education provider patient relationships quality care practice implications tool testing clinicians understanding patients thoughts feelings contribute better quality care improved selection training elsevier ireland ltd rights reserved
report isolation molecular cloning initial characterization gene encodes putative protein homologous family signaling transcription regulators promoter region gene contains four recognition sites protein suggesting transcription gene induced alkaline growth conditions enhanced expression profile gene alkaline environment confirmed northern blotting analysis also report disruption gene decreased secretion proteases ability mutant grow human nail fragments sole source nutrition growth appear related molecular events depend action protein
article reports results study investigating efficacy proportional problem solving intervention schema based instruction grade participants included students mathematical difficulties problem solving initial pool grade students larger study teachers students larger study randomly assigned control condition teachers conditions provided instruction topics ratio proportion percent found students classrooms scored average higher counterparts control classrooms posttest delayed posttest administered weeks later given students difficulties proportional problem solving consequences difficulties important contribution research finding provided appropriate instruction students capable enhanced proportional problem solving performance
early efforts establish dietary recommendations focused defining minimum intakes nutrients needed prevent deficiency diseases although early recommendations proven successful preventing deficiency diseases new knowledge regarding functions nutrients biochemical physiological gene levels shifted emphasis defining kinds amounts nutrients needed optimize physiological mental functions prevent minimize development degenerative diseases now dominant public health concerns several challenges faced producing recommendations based new knowledge recognized nutrients consumed isolation one another interactions single nutrient nutrients foods need taken account making dietary recommendations nutrient another factor influence dietary recommendations genetic variation humans new knowledge regarding effects genetic variability human metabolism ultimately lead development dietary recommendations address genetic influences nutritional needs specific segments population
powerful inhibitor osteoclast activity plays important role bone metabolism patients relationship bone mineral density bmd important remains unclear yet study objective assess role related osteoporosis patients cross sectional study realized cohort chronic patients inclusion criteria elderly prevalent patients age years old exclusion criteria previous bone disease previous renal transplant hormone replacement therapy data regarding clinical characteristics including treatments mineral cardiovascular complications recorded serum mineral markers levels measured bmd assessed quantitative ultrasound measured broadband ultrasound attenuation speed sound stiffness index high levels associated higher bone mineral density malnutrition anemia advanced age correlated bone males higher bone density parameters females patients treated vitamin bmd increased comparing patients without treatments levels directly correlated bone mineral density parameters study confirms critical role pathogenesis osteoporosis whether increased protect bone loss patients undergoing remains established
background studies clearly indicate parenting practices relate child externalizing behaviors although mechanisms underlying relation less understood limited evaluation child routines self regulation relation variables known studies evaluated variables simultaneously objective study examined child routines self regulation serial mediators relations positive negative parenting practices separately child externalizing problems among preschool children methods participants included maternal caregivers preschool children completed measures parenting practices childs daily routines self regulation externalizing behaviors results results demonstrated child routines self regulation significant mechanisms negative positive parenting practices relate externalizing problems preschoolers although temporal sequencing respect negative parenting findings offer preliminary evidence child routines play critical role self regulation development among preschool children turn inversely associated externalizing behaviors conclusion although study needed findings suggest child routines self regulation development key components incorporate clinically evaluate empirically among intervention programs designed prevent early development behavior problems preschool children
japanese prime emerged japanese politics second term office now widely regarded rare example strong leadership seeks arrest reverse perceived decline strategy achieve objectives come known represents radical risky shift foreign policy article outlines evolving applies behaviour mechanisms global governance highly pertinent overlooked example argues although strategic coherent approach global governance emerged previously evident expense norm traditionally shaped role
two adult life history types among species parasitic former final interval sexual maturation immediately extensive studies directly compare hormone profiles life cycles species yet data explain differences development reproductive maturation feeding status present study uses immunohistochemistry show life cycle profiles releasing hormones iii brain species american comparison extensive published immunohistochemical data hormones parasitic species sea complete two cloned deduced amino acid sequences compared previously published species used expression studies northern blotting throughout life cycles although iii immunohistochemistry revealed similar distribution immunoreactive cells fibers two species life cycles qualitative evaluation staining intensity implied early activity brains species particularly iii seems important larval life early species novel feature immunohistochemical study monthly observations distribution relative intensity two critical period final sexual maturation lead spent animal nucleotide sequences identity respectively earlier increase expression life since correlation timing development maturation brain intensity expression concluded yield products likely play substantial role development maturation events lead adult life history species elsevier inc rights reserved
background aging naturally triggers decline cognition result deterioration cerebral circuits thus executive functions suffer changes progress mild severe states impairment exercise instead works strategy cognitive enhancement modulating neuronal plasticity regulation bdnf however whether exercise dependent bdnf improve higher complexity processes still studying process results current data exercise dependent bdnf changes aging individuals course cognitive impairment summarized investigate whether exercise regulation bdnf effective long term changes executive controls exercise dependent regulation bdnf currently role exercise dependent bdnf tool improvement individuals dementia still less clear seldom discussed summary findings indicate limited number studies addressing exercise order discuss parameters related either bdnf executive functioning population conditions total studies presenting analysis parameters nonetheless positive outcomes bdnf variables displayed populations exposed exercise across studies aerobic exercise shown major source enhancement bdnf dependent executive functioning compared cognitive stimulation moreover effect exercise dependent bdnf domains executive functioning appears occur dose dependent manner aging individuals independently cognitive condition
purpose analyze recent trends utilization various thoracic imaging modalities medicare population methods medicare part databases reviewed codes pertaining noninvasive imaging selected grouped seven categories ray computed angiography nuclear scans mri angiography ultrasound yearly utilization rates per medicare beneficiaries calculated medicare physician specialty codes used determine many studies performed radiologists versus physicians results total utilization rate chest imaging peaked per progressively declined radiologists share thoracic imaging increased among providers total utilization rate chest rose sharply peaked remained steady around recent years utilization rate rose progressively utilization rates nuclear chest imaging decreased steadily chest ray rates reached peak declined change largely responsible decline total thoracic imaging conclusion overall thoracic imaging utilization rates declined recent years despite increase use decline largely resulted decrease use chest rays american college radiology
conceptually new algorithm sea ice concentration retrieval polar regions satellite microwave data discussed algorithm design favorably contrasts known modern algorithms design based physical emission model sea surface sea ice cover atmosphere system tie points used algorithm calculation expressions derived theoretical modeling design algorithm minimizes impact atmospheric variability sea ice concentration retrieval beside estimating sea ice concentration algorithm makes possible indicate ice areas melting melt ponds algorithm simple use complicated time consuming calculations involved published elsevier ltd rights reserved
parental factors linked childhood anxiety hence parental involvement cognitive behavioral therapy cbt anxious children examined however findings consistently show added effects parent enhanced cbt longitudinal investigations scarce long term effects unclear present study families years previously completed one two types cbt treatment limited active parental involvement assessed using semi structured diagnostic interviews diagnostic status years follow compared groups changes diagnostic status across assessment points posttreatment month year follow analyzed within groups diagnostic change month year follow compared groups intent treat analyses revealed significant difference diagnostic status groups year follow nonetheless children whose parents actively participated treatment showed significantly remission month year follow children limited parental participation
reproduction relatives often health survival resulting offspring depression manifest immunological costs individuals suffer increased propensity disease infection parasites compared assess intestinal parasite loads wild vary coefficient standardized multi locus find significant association increased lower parasite loads however correlation stand considering findings explained local genetic effects linkage genetic markers genes influencing parasite burdens indeed find certain loci correlate parasite load although local effects lost following multiple test correction warrant future investigation determine strength impact also suggest frequent within mean better predictor facilitates linkage increasing chances neutral markers representing genome wide finally neither significant influence loads two specific gastrointestinal parasites nevertheless heterozygous individuals benefited reduced overall parasitic infection genetic diversity appears explain variation parasite burdens
order locate source signal accurately frequency bands novel primary user localization algorithm based compressive sensing cognitive radio networks proposed paper comparison existing locating algorithms shows higher locating accuracy exploring correlation source signal secondary users energy detection first adopted collecting energy source signal degree correlation source signal reconstructed based compressive sensing determines weights coordinates weighted scheme finally utilized estimate source position simulation results show smaller maximum error positioning root mean square error moreover proposed algorithm possess excellent location accuracy strong anti noise performance
low cost portable constructed featuring low voltage programmable color light sensor frequency converter cmos bit microcontroller display instrument successfully facilitated introduction application spectroscopy groups middle school high school undergraduate students series tried tested laboratory experiments demonstrate utility capabilities developed laboratories help characterize also feature challenging problems allow students realize limitations analytical instruments accompanying laboratories enable students determine concentration mixture food dyes using simultaneous equations quantify inorganic phosphate various aqueous based agricultural samples calculate concentration acid facial medication elucidate iron reaction
article determines natural frequencies vibration corresponding mode shapes suspension bridge varying bending stiffness cables examines variations occur characteristics respect parametric changes bridge single span suspension steel flexible cables selected initial model used studying dynamic characteristics suspension system help finite elements method parameter studies bridge model presented vibration characteristics studied function structural material parameters flexural stiffness cable mass density structural components generally found bending stiffness main cable contributes considerable effect natural frequencies type suspension system simplified expression predicting natural bending frequencies suspension bridge taking account bending stiffness cable developed application first step design process
obstetric hemorrhage bring significant challenges optimal management requires systems based multidisciplinary approach implementation leadership now cornerstone successful hemorrhage management national partnership maternal safety recently released patient safety bundle maternal hemorrhage bundle lists resources implemented every delivery unit country optimize readiness recognition response reporting systems learning obstetric hemorrhage expert systems based response help lead bundle implementation clinical teams responding obstetric hemorrhage
human metabolism investigated using several vitro methods however current methodologies often expensive tedious complicated last decade combination mass spectrometry simpler cheaper alternative mimic human metabolism paper describes development microfluidic device screen printed electrode monitoring phase gsh reactions proposed chip potential used primary screening tool thus current vitro methods
problems result locally non hence non smooth state space equations often encountered engineering examples include problems involving material laws pertaining plasticity impact highly non linear phenomena estimating parameters systems poses challenge particularly since majority system identification algorithms formulated basis smooth systems assumption observability time invariance smooth system observable state remains observable throughout system evolution exception selected state vector however non smooth system observable set states parameters vary evolution system throughout dynamic analysis cause standard identification methods extended kalman filter temporarily ultimately fail accurately identifying parameters system work influence observability non smooth systems performance extended kalman filters discussed novel algorithm particularly suited purpose termed discontinuous extended kalman filter proposed elsevier ltd rights reserved
synthesis conjugates synthetic analogues potent selective histone inhibitor reported moiety parent compounds cap group allow chemical conjugation analogues assayed across panel retained potent selective inhibitory activity towards class isoforms conjugate shown pull
state experienced night april lasting approximately hours average particulate matter approximately diameter emergency department main tertiary hospital managed total emergency calls higher order peak load patients event manifested approximately hours onset major emergency command centre hospital ensured department maximally organized terms disaster management established protocols brought action multiple timely meetings efforts effectively execute plans included rapid emergency medical services time staff maximizing bed space preventing dust entry certain administrative processes day surgeries affect inpatient morbidity additional respiratory equipment patients mainly exacerbations asthma respiratory distress trauma surprisingly incidence injuries vary
left atrial enlargement known early sign left heart disease prognostic implications heart failure importance right atrial enlargement less studied prognostic implications size comparison understood aim study test hypothesis area larger area apical four chamber view associated cause mortality elderly patients independent left ventricular ejection fraction patients hospitalized april april underwent enrolled cause mortality registered follow least baseline parameters measured area area volume left ventricular mass tissue doppler systolic velocity right ventricular free wall presence severe gradient central venous pressure systolic pulmonary artery pressure parameters diastolic function univariate analysis larger associated cause mortality hazard ratio relation larger cause mortality remained even adjusting age heart rate atrial fibrillation percutaneous coronary intervention index volume index presence severe larger independently associated cause mortality elderly patients hospitalized due
paper present intelligent reliable storage efficient video surveillance system using apache storm storm topology added multiple information extraction modules write important content disk topology extensible capable adding novel algorithms per use case without affecting existing ones since processing independent framework also highly scalable fault tolerant makes best option organisations need monitor large network surveillance cameras
convey information individuals motivational internal social status circumstances change individuals respond adjusting vocal behavior accordingly european male site socially males dramatically increases although circulating testosterone associated social status vocal production possible steroid receptors fine tune status appropriate changes behavior explored possible role androgen receptors male acquired sites produced high rates subset males occurred even absence elevated circulating testosterone androgen receptors highest medial nucleus males site elevated testosterone higher dominant males high testosterone males longer dominant males low testosterone males shorter dorsal medial portion nucleus elevated males high testosterone irrespective dominance status length related positively testosterone concentrations related positively results suggest role testosterone vocal behavior differs across brain regions support hypothesis testosterone underlies motivation testosterone relates quality testosterone stimulates data also suggest influence independent testosterone alternative androgen independent pathways regulate status appropriate behavior elsevier inc rights reserved
free viewpoint video offers compelling interactive experience allowing users switch viewing angle time composed large number camera captured views virtual views captured camera rendered nearby using techniques depth image based rendering consider group wireless users interact independently switching views study novel live streaming network user subset server via primary channel enhance availability user user generates network coded packets using direct neighbors via secondary channel given limited primary secondary channel devices seek maximize received video quality minimize distortion jointly optimizing set device combination generate packets best knowledge among first body work addressing joint optimization problem wireless live streaming based collaboration first formulate problem show hard propose scalable effective algorithm called peer assisted video node pull packets share minimize video distortion neighborhood extensive simulation studies show outperforms algorithms achieving substantially lower video distortion often significantly less redundancy much android based video experiment confirms effectiveness comparison schemes
loss extracellular superoxide dismutase contributes inflammatory fibrotic lung diseases human polymorphism decreases matrix binding lung extracellular fluids protects lps induced alveolar inflammation used mice expressing naturally occurring single nucleotide polymorphism within heparin binding domain results amino acid substitution position test hypothesis redistribution extracellular fluids protection bleomycin induced lung fibrosis secondary pulmonary hypertension mice content activity increased extracellular fluids decreased lung baseline greater increases bronchoalveolar lavage fluid compared wild type mice days bleomycin mice developed less fibrosis based pulmonary mechanics fibrosis scoring collagen quantification gene expression days less right ventricular systolic pressure pulmonary medial wall thickening days wild type mice macrophages lymphocytes neutrophils proinflammatory cytokines protein increased day mice total cell counts increased day resolved days days pro cytokines protein higher mice resolving days conclude redistribution result single nucleotide polymorphism protects mice bleomycin induced fibrosis secondary improved resolution alveolar inflammation
social learning requires inferring social information another person evaluating outcomes previous research shows prior social information biases decision making reduces reliance striatal activity learning nature neuroscience rich literature social psychology person perception demonstrates people spontaneously infer social information viewing another person engage network brain regions including medial prefrontal cortex temporal parietal junction superior temporal precuneus nature reviews neuroscience van human brain mapping investigate role brain regions social learning established dimensions person perception trait warmth trait competence test hypothesis activity person perception brain regions interacts learning structures social learning participants play investment game choose agent behalf choice guided cues signaling trait warmth trait competence based framing monetary returns trait warmth information impairs learning human computer agents trait competence information produces similar learning rates human computer agents see increased activation warmth information human agents person perception brain regions interestingly activity person perception brain regions decision phase negatively predicts activity striatum feedback trait competence inferences humans results suggest social learning engage additional processing within person perception brain regions learning economic contexts
discretization method proposed rather general class nonlinear continuous time systems piecewise constant input one digital control via zero order hold device resulting discrete time model expressed product integration gain system function dynamics original continuous time system made possible use delta euler operator makes comparisons discrete continuous time systems quite simple since difference two forms concentrated integration gain gain determined paper using approximation certain gain condition imposed discretized system exact model method shown produce smaller error norm one uses linear approximation simulations carried averaged van der nonlinear systems show superior performance proposed model ones known online forward difference methods insights obtained useful developing digital control laws nonlinear continuous time systems currently limited simplest forward difference model
superior insect flight enabled rapid significant changes aerodynamic forces result subtle precise change wing kinematics high sensitivity aerodynamic force wing kinematic change demands precise instantaneous feedback control wing motion trajectory especially presence various parameter uncertainties environmental disturbances current work wing robots limited open loop averaged wing kinematics control present instantaneous closed loop wing trajectory tracking motor direct driven wing system resonant dynamic model parameter uncertainties disturbances developed validated system identification wing trajectory generation designed oscillator based central pattern generator smooth convergence using linearized model treating nonlinearity disturbance designed proportional integral derivative pid controller linear quadratic regulator instantaneous wing trajectory tracking using original nonlinear model designed nonlinear controller achieve robust performance control algorithms implemented compared experimentally wing micro air vehicle experiments showed pid nonlinear controls resulted precise trajectory tracking controller tracked less precision smaller input effort addition nonlinear control algorithm achieved better tracking wing trajectories varying amplitude bias frequency split cycles adapting variations wing morphological parameters wing geometry stiffness furthermore lift force measurements nonlinear control results compared open loop average wing kinematics control commonly adopted current designs
spherical inner cell mass confined environment embryonic stem cells derived mimicking vitro mouse often cultured droplets promotes formation cells sediment aggregate owing increased physical confinement cell cell interactions contrast form two dimensional flat substrates remains unclear difference organization owing lack physical confinement increased cell substrate versus cell cell interactions employing substrates demonstrate single geometric degree physical confinement surface also initiate experiment computation reveal balance cell cell cell substrate interactions controls morphology organization aggregates physical confinement thus important regulatory cue three dimensional organization morphogenesis developing cells
paper constant voltage power generation system based novel memory machine proposed implemented memory machine offer direct efficient air gap flux control due creative integration memory concept doubly salient machine structure utilizing memory machine direct drive wind power generation resulting system realize constant voltage operation different load conditions addressing memory machine design characteristics analysis using finite element method paper presents detailed implementation control principle constant voltage power generation system numerical simulation prototyping test conducted verify validity proposed machine system elsevier ltd rights reserved
aim study identify novel tnf alpha blocking peptide using display technology two novel tnf alpha binding peptides values identified particles displaying peptides concentration prevent cytotoxic effect tnf alpha cells respectively synthesized peptides also inhibited tnf alpha induced cytotoxicity values respectively result pcr also supports inhibitory activity identified peptides significantly inhibit inductive effect tnf alpha kappa alpha mrna levels inhibitory effects peptides attributed abilities binding interfaces leading tnf alpha dissociation results molecular docking studies revealed peptides tnf alpha complexes mostly stabilized hydrophobic contacts elsevier rights reserved
gas chromatographic positive chemical tandem mass method simultaneous determination oxidative metabolites hydrocarbons alpha delta human urine developed tested general population method involves enzymatic cleavage followed solid supported liquid liquid extraction using two step reaction bis method proved sensitive reliable detection limits ranging contrast frequent distinct quantities detected expected metabolite detected samples metabolites detected almost urine samples procedure enables first time analysis trace levels broad spectrum mono metabolites carboxylic acids human urine analytical procedure powerful tool population studies discovery human metabolism elsevier rights reserved
current study tested hypothesis substance abuse features internalizing externalizing disorder confirmatory factor analysis data supported three factor model negative alternate one two internalizing externalizing factor models second indicated self reported offending substance abuse formed separate dimensions rather single dimension correlating several temperament personality indicators measures substance misuse offending revealed substance misuse significantly aligned internalizing dimension negative significantly less aligned externalizing dimension
recent papers highlight presence large numbers compressed angles metal ion coordination geometries entries worldwide protein data bank due mainly coordination prevalence compressed angles raised controversial idea significantly aberrant even novel coordination geometries exist papers undergone severe apparently due views held canonical coordination geometries exist significant numbers controversial ideas warranted expected believe line crossed put forth result compressed angles exist large numbers support canonical coordination geometry view present review major controversial results pointing good suggestions incorporated new analyses also put forth support particular view also suggest better science enabled collaborative approach future critical reviews requirement description methods data including source code visualizations enables full reproducibility results proteins wiley periodicals inc
multiple sclerosis inflammatory neurodegenerative disease central nervous system primary symptoms include loss sensory motor function exercise shown modulate disease parameters experimental autoimmune encephalomyelitis mouse model reducing immune cell infiltration oxidative stress however initial studies carried exclusively female mice present study compared effects daily voluntary wheel running several disease parameters male female mice male female mice given access running wheel day consecutive days daily wheel running significantly improved clinical scores males little effect clinical signs females disease direct comparison inflammation axonal injury oxidative stress male female mice revealed significant differences amount cell infiltration microglia reactivity demyelination integrity male mice given daily access running wheels also significantly less ongoing oxidative stress compared groups taken together results indicate inflammatory response generated distinct sexes modulation daily exercise sex specific effects disease related outcomes elsevier rights reserved
high level separate algorithm design platform implementation allowing programmers focus algorithms building complex systems separation also provides system programmers opportunity optimize platform services application application basis gate arrays platform level extends memory system unlike general purpose processors memory hardware fixed design time capacity topology fpga memory systems tuned improve application performance since application kernels explicitly use memory resources substantial memory capacity available platform use behalf user program work present utilizes resources construct program optimized memories also perform initial exploration methods construction application specific memory hierarchies although exploiting resources beneficial consuming memory resources cause frequency degradation relieve timing pressure large block ram structures provide techniques trade memory latency design frequency demonstrate examining set benchmarks scalable cache achieves performance gains geometric mean average baseline cache scaling size first level maximum
paper proposes simple method add optional live streaming highly interactive class way reduces number students physically present classroom student performance effect allowing live streaming analyzed running experiment semester students advanced level computer graphics class given option attend class remotely using live stream class required use multi featured audience response system results show allowing remote attendance decreased number students attending physically registered students effect students believed remote attendance just effective learning attending classes face face analysis data confirmed beliefs however generally prefer physically present class results suggest appropriate use live streaming coupled audience response system reduce demand large lecture allowing self selected subset students attend classes remotely large percentage students class felt live streaming option added classes paper demonstrates goal feasible
ovary syndrome common endocrine disease reproductive age women present study aimed determine effects dietary approaches stop hypertension diet reproductive hormones plasma total antioxidant status anthropometric indices overweight obese women randomised controlled clinical trial women randomly assigned one two diets energy restriction diet control diet control diets consisted carbohydrate protein total fat diet designed rich vegetables fruits whole grains low fat dairy products low saturated cholesterol refined grains present study anthropometric indices body composition total testosterone sex hormone binding globulin free androgen index scavenging activity measured months resultsthe consumption diet compared control diet associated significant reduction weight versus body mass index bmi versus fat mass versus serum versus value increased concentrations versus nmol scavenging activity versus also found group conclusionsthe diet improve weight loss bmi fat mass furthermore result significant reduction serum significant increase antioxidant status
aim paper discuss electrical machines building computation taking account change reluctance network topology required optimization process indeed electrical machine changes electrical period model consider several rotor positions analyze harmonic influence machine performance torque losses requirement also important applications machine geometry changes shortly sizing process optimization two cases addressed paper using established independent meshes initial paper proposes algorithm deal topologies necessary optimization process aims reduce computation time increase model improve solving stability output selectivity approach also applied modeling improve computation time optimization process simulation results compared finite element methods optimization performance presented
background infection severe infants case control study conducted investigate potential role breast feeding protecting young infants methods hospitalized infants months age positive real time polymerase chain reaction enrolled cases healthy controls enrolled among patients admitted ultrasound screening infants excluded socio demographic clinical feeding information collected effect breastfeeding investigated multivariable analysis breast milk blood samples obtained mothers patients iga bacterial binding bacteria tested breast milk igg toxin tested serum results enrolled patients cases controls exclusive breastfeeding associated compared partial breastfeeding artificial feeding odds ratio confidence interval children siblings higher risk odds ratio iga antigens higher cases iga anti median optical density compared controls iga anti median optical density though bacterial binding measured breast milk higher cases median compared controls median bacterial binding low compared pathogens igg titers higher mothers cases correlation found serum igg breast milk iga conclusion breastfeeding remains mainstay prevention numerous diseases though seem play role alternative strategies protect infants considered
ventilation standards health indoor air quality adequately examined residential randomized trial showed houses houses influenced ventilation rates moisture balance indoor air quality self reported physical mental health outcomes average total airflow nearly twice high volatile organic compounds formaldehyde carbon dioxide significantly reduced newer standard first floor marginally lower older standard formaldehyde significantly decreased humidity group half group using moisture balance metric higher lower first floor children group fewer headaches eczema skin allergies adults improvements psychological distress indoor air quality health improve accompanied residential ventilation standard standard greater improvements certain outcomes compared standard home repair energy conservation projects use newer standard improve indoor air quality health
according recent report turkey now considered one worlds since place list top countries information technology offshore services last decade country made excellent progress software sector reflected rise many countries article present overview advancement software sector including current trends software process testing quality adoption agile methods along incentives provided government
article establish new general traveling wave solutions space time fractional equation quadratic nonlinearity space time fractional breaking soliton equations using modified simple equation method proposed method powerful effective solve nonlinear space time fractional differential equations modified riemann derivative
petroleum making increasingly important contribution transportation fuel supply generally expensive greater environmental burdens petroleum conventional sources life cycle assessments alternative fuel vehicle technologies typically consider conventional internal combustion engine vehicles gasoline produced average petroleum used baseline large scale deployment alternative fuel vehicle technologies decrease petroleum demand lead decreased production economic margin oil considered current marginal petroleum resources larger impacts average petroleum resources environmental benefits petroleum demand reduction underestimated current modeling approaches often models include based impacts indirect land use change exclude others avoided oil production approach inconsistent provide robust basis public policy private investment strategy decisions provide example illustrate potential scale impacts research needed establish quantify marginal effects incorporate conventional alternative fuel vehicle technologies
equivalent electrical network generally used cad software presented based pspice model already presented model valid static regime developed since correct parameter estimation important model valid transient regimes detailed electrostatic capacity determination future model improvements presented
aims studies examined experiences people psychosis using representative sample aiming obtain results concerning context increased emphasis involving australian mental health service delivery policy frameworks study recruited within second australian national survey psychotic disorders survey high impact psychosis ship given ship participants long term illness extended relationships health wellbeing group expected relatively stable however since unknown whether health wellbeing change main aim explore change stability health wellbeing relationship changes experienced individual corresponding ship participants functioning time methods ninety eight caregivers ship participants recruited baseline completed validated instruments assessing health wellbeing seventy eight interviewed year follow clinical factors extracted ship database wilcoxon matched pairs signed rank test test used analyse changes variables time cross lagged analyses conducted identify possible causative relationships changes ship participant variables results substantial percentage experienced social isolation psychological distress poorer quality life population norms statistically significant changes baseline follow scores almost health wellbeing variables poorer perception quality life relation physical health year cross lagged analyses suggested poorer functioning people psychosis influenced social isolation psychological distress conclusions findings show perception health wellbeing improve within current mental health service delivery frameworks time poor health wellbeing suggests pressing need enhance services improve health wellbeing especially physical health functioning people psychosis support
residential domestic hot water energy consumption represented household heating demand improvement building insulation envelope domestic hot water contribution energy consumption expected increase significantly values single family buildings almost buildings energy currently lost environment recovered waste water heat recovery systems inside buildings building solutions publications field focus heat recovery waste water heat source heat pumps detailed impact waste water heat recovery city scale building data addressed yet furthermore waste water heat recovery potential relevance yet quantified function specific household numbers end use occurrence building type age method quantify building specific energy cost energy saving potentials based analysis urban scale building waste water heat recovery systems therefore proposed complementary method spatially allocate characterise grey water streams thermal load temperature levels function building specificities also developed methods applied two case studies first solution city second optimisation measure high efficiency residential buildings grey water heat recovery reduce residential fuel consumption city integrated approach combining grey water heat recovery hot water heat pump yields electricity savings passive single family houses buildings respectively detailed characterisation various grey water streams function number end use occurrence quantification energy savings costs heat recovery improved outcomes urban energy cost assessments concerning grey water heat recovery specific results building level aggregated considered geographical scope proposed method therefore current urban energy cost assessments detailed integration building grey water heat recovery systems published elsevier ltd
initiative developed trees grow function real time water carbon monitoring modeling network high quality measurements flow stem diameter variation collected individual trees automated data processing using cloud service enables instant visualization water movement radial stem growth used demonstrate sensitivity trees changing weather conditions drought heat waves heavy rain true innovation lies use high precision data also process based tree models real time makes displaying much needed mechanisms underlying tree responses climate change possible continuous simulation describe growth processes long term time series hydraulic resistance assess drought vulnerability real time opportunities approach offers developed view complementary existing forest monitoring networks aim contribute existing dynamic global vegetation models provides high quality data real time simulations order advance research impact climate change biological response trees forests besides application natural forests answer climate change related scientific political questions also broader societal application selecting trees nature public areas cities university areas teach create public awareness effects changing weather conditions trees forests era climate change
purpose one largest energy consumers transport sector significant impacts environment developed south china plays leadership role promoting development energy efficient vehicles china methods paper aims assess carbon footprint via life cycle assessment method consequently current environmental performance evaluated improvement potentials examined results discussion results show gained rapid growth past decade annual rate closely corresponding growth gross domestic product total estimated million ranging road based transport accounts largest share emissions significant contributors sector light duty urban public transport bus service passenger air transport meanwhile study took new energy vehicles consideration order explore range mitigation potential potential carbon significant comparison impact growth derived increasing passenger transport based assumption transport intensity annual growth rate maintain current levels conclusions study offers useful approach evaluate available options sustainable transport system planning carbon emissions reductions policies technological innovations essential facilitate transition low carbon addition methodology developed study used assessing sectors
background functionalized nanoparticles nps one promising tool detecting specific molecular targets combine molecular biology nanotechnology aiming modern imaging aimed ligand directed delivery suitable target biomarker detect early pancreatic adenocarcinoma promising targets due strong expression cells occurrence early stages cancer precursor lesions adjacent normal tissues results molecular probes long peptides derived human tissue activator selected binding partners affinity constants synthesized peptides determined long peptide functionalized serine revealed strongest binding properties fold higher comparison native protein showed additional strong binding also expressed peptide selected vector moiety linked covalently onto surface biodegradable iron oxide nanoparticles nps particular doped nps promising contrast agent magnetic resonance imaging mri selected magnetic core coated different polymers chitosan chitosan nps acid obtaining polymeric nanoparticles already approved drug delivery applications binding efficacy nps determined exposure different pancreatic cell lines assessed flow cytometry vivo targeting imaging efficacy nps evaluated applying murine pancreatic tumor models assessed magnetic resonance imaging mri nps protease activated nps outer showed clearly detectable drop subcutaneous tumor staining intensity indicating considerable uptake injected nps post mortem deposition tumors organs confirmed staining histopathology tissue sections conclusions targeted nps indicate fast enhanced deposition nps murine tumor models steps strategy nps delivery deposition pancreatic tumor promising
magnetorheological known smart material whose mechanical properties changed external magnetic fields aim paper present results studies properties new developed consisting carbonyl iron particles matrix made rubber samples fabricated constant magnetic field specimens shear mode investigate dynamic viscoelastic properties sinusoidal loadings different displacement amplitudes frequencies tests loading case carried four different magnetic field strengths stepwise results dynamic properties samples obtained terms experimentally determined shear storage modulus loss factor results demonstrate properties variable stiffness high loss factor
conflicting evidence contribution maternal depression family adversity depression experienced offspring maternal depression family adversity related need determine independently contribute offspring depression data long running prospective birth cohort study university study pregnancy outcomes study offspring followed years age first examine association maternal depression family adversity period pregnancy child reaching adulthood consider extent maternal depression family adversity trajectories period predict dsm episodes depression offspring mothers years age find strong directional association maternal depression family experiences adverse life events entire period child home adjustment children family experiencing high levels adverse life events likely experience lifetime ever dsm diagnosis depression likely experienced multiple episodes lifetime ever depression likely report first episode depression younger age findings suggest association maternal depression offspring depression appears partly attributable higher levels family adversity characteristic depressed mothers elsevier ltd rights reserved
examined association prejudice four correlational studies assessed empathy motivation control reactions subtle prejudice expression prone participants likely motivated control prejudice outgroup african americans studies motivation control prejudice mediated relation reduced subtle prejudice expression studies finally stronger motivation control prejudice subsequent prejudice expression reduction mediated empathy accompanied higher levels studies implications intergroup perception specifically attitudes elsevier ltd rights reserved
sleep learning promotes quantitative strengthening new memories less known impact sleep qualitative memory focus review studies shown declarative system sleep facilitates abstraction rules schema formation integration knowledge existing schemas schema integration creativity requires existing patterns schema schema formation integration primarily benefit slow wave sleep whereas schema facilitated rapid eye movement sleep procedural system sleep motor memory neural mechanisms processes remain determined notably emotions shown modulate sleep related memories final section review propose sleep related memories particularly relevant mental disorders thus sleep disruptions contribute disturbed memory development mental disorders therefore sleep related interventions modulate memories provide new treatment elsevier ltd rights reserved
article shows two dimensional analysis model predicting eddy current loss winding flux switching permanent magnet open circuit finite element method used electrical machine design however numerical method always time consuming depending geometry mesh quality finite element method high thus finite element method time consuming special electrical machines solve problem sub domain model using fourier analysis improved flux switching permanent magnet machine obtained solving poisson laplace equations polar coordinates domain magnet air gap rotor stator external region model accounts influence interaction stator air gap rotor air gap magnetic field distribution flux linkage back force torque eddy current loss waveforms derived analytical method verified finite element analysis best knowledge authors analysis carried previously
people highly visible perceived also important influential good bad influence extent people rely irrelevant visual fluency cues forming impressions based recent work affect cognition two experiments predicted found positive affect increased negative affect eliminated effects visual fluency impressions experiment mood induction participants read two people whose visual fluency manipulated changing size color photos mood visual fluency influenced impressions significant mood visibility interaction positive affect increased negative affect eliminated effects visual fluency experiment replicated results different mood induction also found mood induced differences information processing style mediated effects relevance findings impression formation everyday situations considered implications recent affect cognition theories discussed elsevier inc rights reserved
gastrointestinal disease common among hiv infected individuals prevalence distribution rectal pathology studied setting objective study therefore determine prevalence determinants rectal pathology hiv infected patients attending general hospital hiv treatment centre hospital based cross sectional study undertaken collected socio demographic clinical laboratory data using structured questionnaire patients files study participant full physical rectal examination studied factors associated least one rectal lesion logistic regression reporting odds ratios ors confidence intervals included hiv infected patients mean age years men median duration since hiv diagnosis interquartile range years median cell count interquartile range cells prevalence rectal pathology common lesions found patients multivariate logistic regression factors associated rectal pathology cells highly active antiretroviral therapy inpatient rectal intercourse one sexual partner rectal pathology common amongst hiv infected patients care actively investigate treat improve quality life people living hiv aids
amygdala attracted considerable research interest potential involvement various neuropsychiatric disorders recently attempts made using magnetic resonance imaging mri evaluate integrity axonal connections amygdala pathological conditions although pathways studied extensively animal models anatomical references human brain limited histology based resources small number slice locations orientations annotations present study performed high resolution mri postmortem human brains followed serial histology histology data used identify pathways anatomical assigned structures extended using mri data able define detailed anatomy pathway anatomy nearby basal areas including substantia present results help understand detail white matter structures associated amygdala serve anatomical reference design vivo mri studies interpretation data
paper present mechanistic model integrates structures namely ion channels membrane fatty acids lipid proteins cytoskeleton dynamic system tuned healthy brain also argue subtle changes composition membranes fatty acids lead stream effects causing dysregulation membrane cytoskeleton interface sensitivity minor changes known occur physical systems undergoing phase transitions simplest studied called model exhibits phase transition finite temperature ordered disordered state dimensional space propose model context neuronal dynamics hypothesize involve quantum degrees freedom dependent upon variation membrane domains associated ion channels finally provide link physical characteristics dynamical mechanism psychiatric disorders major depression antidepressant action
approximately hiv seropositive individuals develop hiv associated neurocognitive disorders hand commonly include alterations executive functions inhibition set shifting complex problem solving executive function deficits hiv fairly characterized however relatively studies explored elemental dimensions neurocognitive impairment hiv deficits temporal processing caused hiv underlie symptoms impairment higher level cognitive processes translational measures temporal processing including cross modal inhibition ppi gap inhibition gap ppi gap threshold detection studied mature ovariectomized female hiv transgenic rats express hiv genes constitutively throughout development cross modal ppi revealed relative manipulation interval hiv animals comparison control animals extending previously reported temporal processing deficits hiv rats advanced age suggesting temporal processing deficits gap ppi hiv animals exhibited relative manipulation comparison control animals gap threshold detection hiv animals displayed profound differential sensitivity manipulation gap duration presence hiv transgene diagnosed accuracy using gap threshold detection measures understanding temporal processing deficits hiv rat vital modeling neurocognitive deficits observed hand provides key target development diagnostic screening tool
losing among devastating events occur peoples lives use longitudinal data participants german socio economic panel study examine life satisfaction changes experience loss whether socio demographic factors social health resources moderate loss related changes life satisfaction whether extent anticipation reaction adaptation loss associated mortality results reveal life satisfaction shows declines two half years prior anticipation steep declines months surrounding reaction lower levels loss adaptation older age associated declines less steep reactive declines additionally younger age better health social participation poorer partner health associated better adaptation higher pre loss life satisfaction less steep reactive declines better adaptation associated longevity discussion focuses utility examining among anticipation reaction adaptation understanding change life satisfaction context major life events
previously found represent versatile delivery platform early detection intervention orthopedic implant article evaluated impact different structural parameters system molecular weight drug content pharmacokinetics profile using labeled dexamethasone conjugates different dexamethasone contents found predominant impact factor profiles content secondary impact factor gamma counter based studies increased reduced elimination leading lower clearance longer half life higher systemic exposure auc live animal optical imaging evaluation distribution peri implant inflammatory lesion increased increased result confirmed analyses cells isolated peri implant regions systemic administration labeled since vitro cell culture study suggested internalization macrophages generally independent content impact content profile likely exerted physiological pathophysiological levels rather cellular level gamma counter based analyses optical imaging analyses content showed fast clearance dynamic light scattering analyses unexpectedly revealed significant molecular aggregation content level mechanisms aggregation fast vivo clearance warrant investigation
prevention sexually transmitted infections stis important part care hiv infected individual stis associated increased risk transmission acquisition hiv among hiv infected persons treatment failures high recurrence rates stis common despite recognized importance prevention discussion sexual health rates screening stis suboptimal moreover rates stis continue increase particularly men sex men msm review focuses common stis seen among hiv infected individuals recommendations screening prevention
development validation surface suspended sediment concentration models derived surface remote sensing reflectance spectra lambda important satellite monitoring coastal waters seven empirical seven spectral reflectance models evaluation surface compared one another laboratory tank one dataset situ measurements two datasets performed different natural waters east china models presented form spectral ratios wavelengths selected list satellite sensor modis unsaturated central wavelengths statistical analysis performed find best models spectral ratios remote sensing monitoring purposes analysis shown empirical models generally superior models solution existence prediction accuracy correlation observed values however models using red green spectral ratio demonstrated approximately accuracy correlation empirical models provides additional support using simple easily calculated empirical models additionally relationships inherent optical properties absorption coefficients lambda provided models benefits aquatic optics remote sensing purposes
protein ubiquitous post translational modification almost biological systems however function stem cell biology far incompletely understood demonstrated involved differentiation mouse embryonic stem cells induced found temporary exposure promote cell derived using stable isotope labeling amino acids cell culture based proteomics approach coupled switch technique total proteins identified specifically one antioxidant enzymes abundantly temporarily reduced antioxidant activity causing transient endogenous hydrogen peroxide accumulation subsequent box binding protein kinase pathway activation present study reveals mechanism differentiation potent strategy affect pluripotent stem cell derived elsevier inc rights reserved
follow studies exist sexual adjust released back community important question given extreme nature crimes lack data expectation one half prison mid life likewise studies exist role cultures pervasive media violence plays report describes year old boy committed witnessed media violence inspired sexual follow information provided community adjustment adult four years release prison multiple indicators brain dysfunction watched film just style crime upon female neighbor media violence literature reviewed developmental abnormalities neuropsychiatric vulnerabilities family dysfunction mental illness case illustrates variables combined screen violence lead sexual
mucosal surfaces line body provide interaction surface pathogenic microbiota host barrier function mucosal layer largely maintained gel forming proteins secreted cells addition mucosal epithelial cells express cell bound barrier signaling functions family transmembrane consists diverse members share characteristics highly extracellular domains inhibit invasion pathogenic bacteria form tight mesh structure protects cells harmful conditions intracellular transmembrane phosphorylated connect signaling pathways regulate inflammation cell cell interactions differentiation apoptosis transmembrane play important roles preventing infection mucosal surfaces also contributions development progression metastasis general transmembrane seem evolved monitor repair damaged functions cancer cells yield survival advantage review presents overview current knowledge functions transmembrane inflammatory processes carcinogenesis order better understand diverse functions multifunctional proteins karger basel
systems produced hydrogel mixed together high shear rates systems promising different uses among formulation new cosmetic matrices cosmetic agents delivery investigation present paper common cosmetic formulation skin care enriched increasing fractions fatty acids olive oil order understand microstructure systems small amplitude oscillation tests nmr self diffusion analysis contrast phase microscopy electric conductivity confirmed addition caused microstructural change starting material turned complex system probably matrix matrix structure present highest fractions added elsevier inc rights reserved
background objective study overview attempts suicide young females relation thyroid profile dysfunction world health report puts yearly global prevalence suicide attempt varies incidence attempted suicide greatly influenced differences age sex race religion culture marital status habitat climate social systems study aimed analyse risk factor mode attempt spectrum association thyroid dysfunction young females materials methods present study conducted department medicine history attempted march cases female years subjects meeting selection criteria evaluated results total female patients admitted emergency ward tertiary care centre study period one half years march till study period patients attempt suicide admitted medical icu tertiary care centre studied resulted prevalence incidence attempt cases poisoning married females rest evaluation patients due suicidal attempt showed cases hypothyroidism hyperthyroidism cases respectively among cases hypothyroidism signs depression present cases whereas cases stress signs frustration anxiety stress depression present cases respectively among diagnosed overall cases stress led suicidal attempt conclusion present study revealed importance hormonal changes occur hypothyroidism causes changes young active females attempt made focus issues future intervene early prevent complications
paper presents based method enables embedding color image binary black white images maintain quality images method maps channels using homogeneous dot patterns patterns use different binary texture arrangement prevent degradation host image maximization problem solved reduce associated noise objective function maximization problem binary similarity measure original binary set randomly generated patterns optimization problem needs solved dot pattern resulting processing overhead long running time overcome restriction parallel computing techniques used decrease processing time specifically method tested using cuda based parallel implementation running gpus proposed technique produces results high visual quality acceptable processing time elsevier rights reserved
health care cost consuming large portion nations gross domestic product placing added economic burdens physicians patients total joint replacement one early targeted procedures evolving health care environment knee surgeons benefit developing critical knowledge health care reforms financial implications medicare access childrens health insurance program act represents cohesive movement toward value based payment reform contains several require detailed attention knee surgeons article provide contextual framework health care legislation led formation current health policy present comprehensive summary update merit based incentive payment systems alternative payment models reimbursement models
recent widespread adoption service oriented architecture dynamic composition services now crucial issue area distributed computing coordination execution composite web services today typically conducted centralized workflow engines leading increasing probability processing communication bottlenecks failures addition induces higher deployment costs computing infrastructure support workflow engine affordable large number small businesses end users world platforms dynamic elastic cloud computing decentralized dynamic interaction schemes required addressing characteristics platforms nature inspired recently attention provide autonomous service coordination top dynamic large scale platforms paper propose approach decentralized execution composite web services based programming paradigm relies chemical provides high level execution model allows executing composite services decentralized manner composed services communicating persistent shared space containing control data flows services architecture allows distribute composition coordination among nodes proof concept given deployment software prototype implementing concepts showing viability autonomic vision service composition
article critically examines certain custom based assumptions theories regarding gender roles norms tradition law first article considers scholarship tradition next processes concept entered tradition law particular considered based assumptions regarding nature gender roles norms neo traditional thought based term gender thesis argue gender thesis strongly influenced manner interpreted respect gender issues basis traditional law ethics constructed particular highlight conceptual link women sources chaos male sexual discourses neo traditional interpretations tradition finally article traditional failed recognize importance comprehensive basis question validity gender based interpretations present neo traditional discourses incorporated law concept custom
replacement vice versa frequent global markets authentication challenging processed foods due fragmentation biomarkers including dna shortening target sequences use two target sites ameliorate assay reliability highly unlikely targets lost food processing first time report polymerase chain reaction pcr assay targeting two different dna regions mitochondrial genes discriminate processed foods targets stable microwave cooking conditions survey markets revealed contained assay detected dna meat products elsevier ltd rights reserved
propose method combines analysis discontinuous method second fourth order geometric flows generate surfaces composed multiple patches technique used tackle challenging problem geometric modeling multi patches together create complex models non uniform rational popular representations geometric models developed computer aided design employed describe geometry represent numerical solution since basis functions two different patches independent methods appropriately applied multiple patches together obtain smooth solutions present semi discrete schemes solve problem stability proved proposed schemes method following advantages firstly geometric flexibility basis functions especially use multiple patches enable construct surface models complex geometry topology secondly constructed geometry fair since control points patches evolve accordance geometric flows number degrees freedom small algorithm efficient finally method easily formulated implemented apply method mean curvature flows quasi surface diffusion flows solve various geometric modeling problems minimal surface generation surface blending hole filling etc examples provided illustrate effectiveness method
investigate impact different living arrangements quality life qol health related quality life hrqol elderly used data first fourth wave korean longitudinal study aging using first wave baseline data included individuals aged years older least one living child qol hrqol measured using visual analogue scale developed korean labor institute similarity vas living arrangements categorized based household composition single household one generation household two generation household three generation household marital status adult child generalized estimating equation used examine association living arrangements qol hrqol compared elderly individuals living three generation families married child single household qol beta hrqol beta living three generation family adult child qol beta hrqol beta living two generation family adult child qol beta hrqol beta likely lower qol hrqol associations particularly strong women individuals lowest equivalent household income group necessary devise government programs elderly individuals living alone also living adult child elderly persons female part lowest equivalent household income group receive particular attention
multidimensional nuclear magnetic resonance nmr provides unique window structure dynamics atomic level traditionally given scan scan time modulation involved experiments duration nmr increases exponentially spectral dimensionality addition acquisition times increase number spectral elements sought indirect domain given ratio spectral bandwidth targeted resolution desired long sampling times substantially reduced exploiting information often available lower dimensionality work presents novel approach exploits previous information speed acquisition spectra based time optimized fourier encoding pre targeted peaks experiments present points common encoded necessarily require scans counterparts demonstrated based extensions single quantum coherence experiments theoretical basis new approach given experimental presented small molecule protein based model systems elsevier inc rights reserved
evaluate compare diagnostic potential different reading protocols non enhanced contrast enhanced diffusion weighted fdg pet imaging lesion detection determination tumor stage lymphoma patients total fdg pet mri datasets including transverse fdg pet pet additional contrast enhanced pet additional diffusion weighted imaging pet evaluated scans performed initial staging treatment end treatment surveillance suspicion tumor relapse datasets lymphoma manifestations tumor stage analogy revised criteria ann staging system determined furthermore potential changes therapy compared reference standard evaluated hitherto performed pet available follow prior examinations histopathology served reference standard pet correctly identified patients active lymphoma lesions respective values pet pet pet determined correct tumor stage examinations corresponding results pet pet relating reference standard changes treatment occur based pet based pet based pet additional application contrast enhanced diffusion weighted imaging fdg pet mri resulted higher diagnostic competence particularly initial staging correct classification disease extent potential impact patient therapy management
background study assessed feasibility acceptability pharmacy home based sexually infection screening alternate testing among emergency contraception users methods study included two phases february july phase customers eight received free testing medical clinics phase three facebook ads targeted users connect free home based test kits ordered online participants completed self administered survey results participants enrolled phase female completed survey requested kits returned phase participants younger less educated phase participants six tested positive stis challenges included recruitment pharmacy staff participation cost conclusions study found low uptake pharmacy home based testing among users however testing settings feasible acceptability findings indicate appeal among younger women testing non traditional settings training pharmacy medical staff key elements service provision future research explore different expanding screening non traditional settings improve testing uptake detect additional cases
cell possesses remarkable ability perceive process chemical physical stimuli turn modulate cellular behavior one great nanotechnology enables fabrication tools length scale biomolecules thereby providing unique handle characterizing controlling basic cellular processes owing tunable size shape dependent physical properties biocompatibility facile surface modification gold nanoparticles become potentially powerful tools probe fundamental aspects cell biology consequently innovative approaches based gold nanoparticles development toward manipulation cell function improvement techniques currently used biotechnology review provide overview recent applications based gold nanoparticles nanostructured materials modulation cellular activity behavior mediated interactions cell surface receptors elsevier ltd rights reserved
background hepatocellular carcinoma hcc frequent type liver cancer occurrence oral cavity metastatic neoplasm rare event describe fatal case hcc oral metastasis patient firstly diagnosed prostatic hepatic carcinomas histopathological examination revealed hepatocyte like tumour cells arranged structures positivity par present findings highlight importance complete medical evaluation patient identify possible oral primary diseases
published iron woman transformation american cultural scene second half century affected powers reflecting extensive change social landscape cultural ideology gender roles family relations novel presents unique exploration experience argue study female maternal experience already established ambivalent discourse mothers american culture exposed challenged iron woman confined within different power relations seek lives mothers culturally socially although lived pre feminist era able anticipate modern feminist argument characterization real mothers struggle society resist traditional prototypes accompany mother figures american cultural mind major concern study discuss challenges number cultural codes socially constructed true woman newly introduced new woman stepping beyond dual ambivalent discourse mothers one hand new maternal path mother characters resist inconsistency culturally embedded notions restrictive mother image actual experiences
recently big effort focused research smart environments learning area already resulted number interesting projects results smart environments learning based approaches technologies deployed related areas ambient intelligence smart environments certainly deserve considerable attention large community oriented technology enhanced learning smart environments learning naturally considered new challenging step computer enhanced learning evolution many new interesting facilities multi agent systems frequently used approach towards smart environments design general systematic approach towards reflecting desirable functionalities smart learning environments based designed architecture moreover number new technologies approaches influenced recent research area smart learning environments let cloud based architectures applications representative contribution tries summarize recent state art area main features successfully implemented projects couple problems presented together vision possible future smart learning environments
despite limited evidence complementary alternative medicine treatments popular autism spectrum disorder aim review summarize available evidence complementary alternative medicine use frequency autism spectrum disorder systematic search three electronic databases performed research studies english german reporting data frequency complementary alternative medicine use individuals autism spectrum disorder included two independent reviewers searched literature extracted information study design results assessed study quality using established quality assessment tool twenty studies total participants included prevalence complementary alternative medicine use ranged median special diets dietary supplements including vitamins frequent complementary alternative medicine treatments ranking first studies evidence higher prevalence complementary alternative medicine use autism spectrum disorder compared psychiatric disorders general population approximately half children adolescents autism spectrum disorder use complementary alternative medicine doctors aware discuss complementary alternative medicine use patients especially evidence mixed complementary alternative medicine treatments potentially harmful
increasing availability high resolution images videos models demand scalable large data processing techniques increases introduce method sparse learning propagation large input data previous approaches propagation typically employ global optimization whole set pixels high memory time consumption large input data rather propagating pixel pixel follow principle sparse representation obtain representative compact perform propagation instead sparse provides intrinsic basis input data coding coefficients capture linear relationship pixels atoms learned optimized novel scheme maximizes divergence atom pair remove redundant atoms enable local propagation images videos similar appearance learning strategy proposed considering range constraint better account global distribution pixels feature space show several applications sparsity based propagation including video theme editing seamless cloning operating color texture features approach also applied computer graphics tasks surface deformation demonstrate atom pixel ratio order significant reduction memory consumption method still maintains high degree visual fidelity
aberrant expression micrornas mirnas processing defects biogenesis pathway widespread phenomenon tumors great importance analysis mirna expression regulation biogenesis gain knowledge role cancer besides proteins key players mirna processing addition role components rna induced silencing complex executing target silencing mediate regulation mirna maturation creating additional intermediate processing step cleaved precursor mirna pre mirna enhancing production stability mature mirnas describe detection mirna levels northern blotting identification end mirnas precursor cloning two many roles proteins addition describe method optimize rnai experiments increasing efficacy specificity target silencing via
recognized distribution first peak adolescence another elderly age group elderly patients different clinical features poorer prognosis compared adolescents better understand biological features elderly population established new human cell line year old man primary months continuous culture vitro cell line established cell line characterized cytogenetic biomarker functional histological analyses cells exhibited spindle shaped morphology time cytogenetic analysis cells revealed loss chromosome gain chromosome quantitative real time polymerase chain reaction pcr western blotting immunofluorescence revealed expression mesenchymal tumor metastasis markers cells compared cell line cells found sensitive doxorubicin resistant methotrexate cell line highly maintained histological characteristics invasive nature original tumor furthermore immunohistochemical analysis metastases found express collagen vimentin original tumor cells results indicate potential cell line serve useful tool studies molecular biology especially elderly patients orthopaedic research society published wiley periodicals inc res
organic comprising type derivative type lead prepared examined terms water phase generated due oxidation fell surface furthermore also induced photocatalytic reaction originated reducing powers produced respectively based photocatalytic studies noted respond wide spectrum solar energy however using metal free type reference type layer application photocatalyst material combination generated show particularly control irradiation thus present work demonstrated utilisation photocatalytic material responding near infrared energy effective towards efficient output product elsevier rights reserved
continuing challenge education system evaluate wider outcomes schools wider measures success lifelong learning influence emerge time complex interactions students teachers leaders wider community unless methods found evaluate broader outcomes able justice learning achievement emergent properties learners engagement world education system continue focus narrow measures school effectiveness properly account complexity article describe rationale methodology underpinning pilot research project applied hierarchical process modelling group schools complex living systems using software developed engineers university called aim generate stakeholder owned systems design better able account full range outcomes valued school complex processes facilitate inhibit thus providing nuanced leadership decision making analytic project involved three
orthogonal modulation example frequency shift pulse position modulation ppm primarily used relatively low rate communication systems operate power limited regime optimal detection modulated signals takes form sequence detection exponential sequence length complexity implemented exhaustive search among possible sequences work first time literature present algorithm performs generalized test optimal sequence detection modulated signals flat log linear sequence length complexity moreover channels proposed algorithm equivalent maximum likelihood sequence detector simulation studies indicate optimal detector coherent detection performance sequence length order offering gain typical energy single symbol detector conventional exhaustive search approach becomes sequence lengths proposed implementation requires log linear number operations opening new avenues practical finally show algorithm also solves efficiently optimal sequence detection problem contemporary radio frequency identification systems
argue federal states face dilemma sub unit autonomy collective problem solving develop structure dilemma pervasive multilevel systems strong element shared policy making pronounced substantial part literature considers relationship discusses ways stabilize propose analytical perspective focuses actor dynamics attempts subunits change balance sub unit autonomy collective problem solving changing position two distinct dimensions exit voice exit measures degree sub units want subject collective policies voice measures influence sub units seek collective decisions illustrate framework examples mainly conclude perspective new light differentiated integration open comparative
airborne dust stable environment strongly implicated asthma ventilation rate stable management activities contribute study investigated relationship breathing zone stable zone eight american eight stable complexes individual four different management regimes airborne dust measured eight replicate per regime eight per regime single regimes follows dry dry samples taken quite periods hours airborne dust levels analyzed using split plot analysis variance wilcoxon matched pairs test significant lowest air found single dry produced air greater air single produced across zones single compared dry dust whereas higher versus across stable designs using dry recommended suitable management regime elsevier inc rights reserved
despite decades study scholarly consensus emerged regarding whether violent video games contribute youth violence small correlations violent game play violence related outcomes due factors include wide range possible effects gender mental health social influences current study examines issue large diverse white black hispanic mixed race ethnicity female sample youth grade models examining video game play violence related outcomes without controls tended return small statistically significant relationships violent games violence related outcomes however predictors included models propensity scores used control underlying propensity choosing allowed play violent video games relationships became inverse reduced trivial effect sizes results offer support conclusion video game violence meaningful predictor youth violence instead support conclusion family social variables influential factors
rapid prototyping methodology digital controllers presented paper main application development test microgrid inverter controllers fulfill application requirements systems characterized complex multilayer architectures extending pulse width modulation pwm current control loops global optimization high level communication functions complexity wide variability different layer implementations make digital control mandatory however developing complex digital controllers conventional hardware platforms like digital signal processors even practical choice paper shows control devices software configurable dsp functions programmable logic circuits efficiently combined represent optimal solution field application furthermore paper proposes hardware loop real time simulation effective means developing complex hardware software controllers case study presented used illustrate different design test phases initial concept numerical simulation final experimental verification
traditional treatments medication surgery management parkinsons disease shown varying effectiveness carry risk significant side effects recent research development wearable suppression technology shown promising third solution management paper presents design novel multi channel use wearable suppression devices system allows single drive motor support multiple independent outputs operation speed direction controlled motor low power characteristic provide promising approach achieving prolonged operating life wearable devices furthermore size scaled according different applications optimal performance paper describes design modeling implementation characterization weight prototype maximum output speed rpm maximum continuous torque addition recorded motion along voluntary movement individuals parkinsons disease used validate performance controlled suppress motion following voluntary movement subject average rms error voluntary motion tracking achieved dynamic suppression test elsevier rights reserved
unmanned aerial vehicles uav gaining popularity due application military private public sector especially attractive fields human operator required light weight desirable better performance terms shorter take range longer flight endurance however light weight structures complex inner features hard fabricate using conventional manufacturing methods ability print complex inner structures directly without need gives additive manufacturing edge conventional manufacturing recent development composite multi material printing opens new possibilities printing lightweight structures novel platforms like ease paper explores impact additive manufacturing structures materials used review discuss state art technologies innovations materials structures advantages limitations role additive manufacturing improve performance smart material actuators multi functional structures also discussed elsevier masson sas rights reserved
background medical use states recreational use however effects use thyroid function autoimmunity unknown methods performed cross sectional analysis data national health nutrition examination survey conducted assess effects thyroid function autoimmunity users included adults ages years responded questions related use laboratory results related thyroid parameters subjects categorized never used past users used prior days ago recent users used within last days using normative cut offs thyroid parameters compared recent users past users calculated odds ratios relative rate clinically significant thyroid dysfunction groups multivariate logistic regression performed control confounders results fifty four percent subjects reported lifetime cannabis use using recently univariate regression analysis showed recent users significantly lower frequency elevated thyrotropin tsh positive anti antibody versus past users controlling confounders recent use remained independent predictor tsh odds ratio negative conclusion recent use associated thyroid dysfunction significantly associated lower levels tsh
background atopic dermatitis chronic relapsing inflammatory skin disease whose management remains unclear non dermatologists study aimed assess knowledge attitudes practices medical staff regarding methods cross sectional study conducted january april health facilities located capital city medical staff provided consent included study score established categories subsequently grouped classes considering score respectively results enrolled medical personnel females overall level knowledge moderate allergy main cause stated participants personnel cited genetic cause asthma mentioned associated pathology regarding attitudes majority thought equally common among black caucasian populations participants believed evolution favorable appropriate medical treatment prescribed attitudes considered wrong similarly general level practice inadequate conclusion levels knowledge attitudes practices medical staff regarding poor implying management condition non optimal setting
study compares lifecycle costs greenhouse gas emissions electric vehicle ownership popular similar cars focuses interaction costs rapid solar uptake using scenario planning approach future fuel electricity prices evs include battery electric vehicles plug hybrid electric vehicles find total cost ownership evs tends higher internal combustion engine vehicle hybrid electric vehicle hev counterparts accounting federal credit however evs become relatively cost effective moreover access residential solar makes evs quite attractive federal solar charging makes full lifecycle cost leaf less expensive next lowest cost vehicle lifetime nonetheless early evs strategy based todays mix electricity generation best performing respectively lifetime best performing hev however many evs become par high performing considering adoption aggressive renewable energy goals electric sector electric sector meets renewable portfolio standard target low carbon sources like wind solar plug leaf become comparable terms impacts integrating residential solar even just charging makes evs outperform regards lifetime emissions addition level charging renewable sources electricity now outperform environmental benefits evs depend critically electricity system derive power given wide variation mix electricity generation throughout even throughout day adoption intermittent sources renewable energy additional policy tools needed match places times high levels charging particular suggest regional approach account emissions intensity electricity systems appropriate current federal credit adoption time use pricing accounts impacts critical supporting evs tool currently however evs relatively costly strategy elsevier ltd rights reserved
rectangular commonly used forms data computer graphics forth need processing cells data represented rectangular paper deal data structures algorithms rectangular data heterogeneous parts particular like introduce algorithm rectangular heterogeneous parts represented
vibration efficient robust tools reducing vibration noise researchers use various alternative approaches validate methods examples consisting mass spring damper systems focusing minimization vibration amplitudes via passive absorber approach new efficient method calculating optimum parameters attached uniform beam mode shapes positive developed first general case dissipation due damping kinetic potential energy effects external forces analyzed equation used provide state space representation system state space representation system mode shapes composed basis state space representation lyapunov function norm transfer function system utilized newly developed optimization package system output minimized optimization algorithm displayed comparison cases without absorber randomly selected absorber parameters conclusion help method calculation optimal absorber parameters one easily design mechanical system according design criteria
paper responds recent calls leadership studies literature informed empirical research leadership phenomena non western non settings authors worked extensively rural development projects draw ethnographic participation interview data explore leadership terrain traditional concepts official government international development agencies theoretical discussion linguistic socially constitutive nature language general offered background justification studying language leadership context distinction operations also introduced differentiate various positions taken relation data discussed paper study shows difficult native speakers find words describe leadership give leaders outside semantic social fields key finding study viewed perspective peoples party authority leadership social fact reflected linguistic restrictions described leadership
nurse reported lead nurses required nursing care south korea reduce informal caregiving patient families improve quality nursing care public hospital operated metropolitan government implemented policy increasing nurse patients per registered nurse patients per registered nurse general nursing units since january study aims compare missed nursing care required care high patients per nurse units low patients per nurse units examine effects nurse missed care methodsa nurse survey conducted july targeted staff nurses four high nine low units nurses high units response rate nurses low units response rate participated missed nursing care measured using survey included nursing care elements nurses asked frequently missed element point scale rarely always nurses working high units significantly lower mean score missed care low units seven nursing care elements missed significantly less often high low units turning mouth care skin care patient assessments shift assistance feeding setting meals conclusionthe findings suggest increasing nurse associated decrease missed care less required nursing care expected improve nursing surveillance patient outcomes patient falls pressure ulcers pneumonia implications nursing health nurse ensured reduce unmet nursing needs improve patient outcomes
widely applied food web model mostly known desktop software microsoft windows platform freely available source code however provides range possibilities use model different ways extend model execute model different operating systems provide overview source code philosophy technical capabilities targeted model advanced users software novel scientific applications model facilitated modular approach system also present three additional versions written different computer languages dedicated purposes lastly provide entry point users obtaining using source code custom purposes elsevier rights reserved
objectives malignant borderline ovarian tumors epithelial origin rarely encountered among girls adolescents aim population based study elucidate clinicopathological characteristics prognosis using multi institutional tumor registry study design outcomes national cancer institutes surveillance epidemiology end results database accessed cohort females aged years old diagnosed borderline ovarian tumor malignant epithelial ovarian carcinoma accessed observed survival assessed using kaplan meier method comparisons made using log rank test results total cases diagnosed identified histology respectively ten year total cases identified median age years common histological subtypes adenocarcinoma stage disease fertility surgery commonly performed five year stage disease compared cases ovarian tumor spread conclusions rare pediatric adolescent population age group consists mostly low grade tumors confined ovary survival stage disease excellent elsevier ireland ltd rights reserved
first goal study investigate whether levels behavior problem solving advice affect management tangible assistance low levels child self direction differ depending context israeli israeli mothers fathers second considered whether association young adults interpersonal sensitivity depends contexts questionnaires collected mothers fathers young adults israeli israeli parents reported behaviors young adults reported interpersonal sensitivity results indicated four dimensions behaviors prominent israeli culture israeli culture advice affect management lower mothers fathers fathers provided child self direction mothers addition higher levels problem solving significantly associated higher levels young adult interpersonal sensitivity independent parental gender cultural background supporting general negative association problem solving interpersonal sensitivity
background evidence informed likely organisations cultures promote research use resources facilitate staff engagement research measures organisations research use culture capacity needed assess current capacity identify opportunities improvement examine impact capacity building interventions aim current study develop comprehensive system measure score organisations capacity engage use research entitled oracle organisational research access culture leadership method used multifaceted approach develop oracle firstly reviewed available literature identify key domains organisational tools systems facilitate research use staff interviewed senior health policymakers verify relevance applicability domains information used generate interview schedule focused seven key domains organisational capacity interview pilot tested within four australian policy agencies discrete choice experiment undertaken using expert sample establish relative importance domains data used produce scoring system oracle results oracle interview developed comprised questions addressing seven domains organisational capacity tools support research use including documented processes leadership training staff training research resources database access systems generate new research undertake evaluations strengthen relationships researchers data conditional model estimated calculate total scores took account relative importance seven domains model indicated expert sample placed greatest importance domains conclusion utilised qualitative quantitative methods develop system assess score organisations capacity engage apply research policy measure assesses broad range capacity domains identifies relative importance capacities oracle data used organisations increase use evidence identify areas development
aims characterise producing cre isolated genes flanking regions amplified sequenced pcr isolates pulsed field gel electrophoresis multi locus sequence typing plasmids bearing genes sized digestion southern blotting dna appropriate probes transfer plasmids attempted conjugation transformation successfully transferred plasmids characterised polymerase chain reaction pcr typing restriction isolates escherichia coli species carried variety genes including apart isolates clonal however appears spread plasmids conclusions number isolates cre increased singapore especially since diversity types reflects geographical proximity countries cre
dna mismatch repair gene homolog critical maintenance genomic integrity methylation gene promoter identified prognostic marker numerous types cancer including colorectal ovarian gastric cancer present study aimed determine whether promoter methylation associated survival male patients esophageal squamous cell carcinoma fixed paraffin embedded tissues collected male patients promoter methylation assessed using methylation specific polymerase chain reaction approach kaplan meier survival curves log rank tests used evaluate association promoter methylation overall survival patients cox regression analysis used obtain crude multivariate hazard ratios confidence intervals present study revealed promoter methylation observed male patients kaplan meier survival analysis demonstrated promoter significantly associated poorer prognosis patients multivariate survival analysis revealed promoter independent predictor poor male patients therefore promoter predictor prognosis male patients
present pipeline algorithms given model parts part printed high outer surface quality exploit fact printing technologies anisotropic resolution hence surface varies significantly orientation surface pipeline starts input surface patches aligned printing direction diagram computed cells surface approximate surface patches cells input models volume provide initial decomposition present algorithm compute assembly order parts generate post processing step optimizes segments improve visual quality run pipeline wide range models experimentally evaluate obtained improvements terms numerical visual quality
study aimed describe rates antipsychotic medication use association use demographics clinical variables use behavioral education services among children asd children asd ages prescribed least one atypical antipsychotic medication respectively multivariable model young children older age use multiple psychotropic medications prior asd diagnosis non white hispanic race ethnicity oppositional problems associated antipsychotic use among older children older age associated antipsychotic use least one age group antipsychotic medication use also related behaviour family occupational therapy public insurance site region externalizing problems body mass index sleep gastrointestinal problems
software defined network structure network fundamental changes network equipment achieve hardware software isolation virtualization technology underlying hardware development network provides platform due hardware software isolation making network vulnerable attack thus changing topology business information solve problem paper depending traffic data corresponding topology method gives security software defined network combined business process model cloud computing network security algorithm optimization simulation results show proposed method robust variety business effectively prevent network attacks
sea sea sea belong protected geographical indications china based high nutritional values medical samples including sea samples province sea samples sea samples province individually collected designated geographical sea areas genetic relationships dna polymorphisms evaluated random amplified polymorphic dna technology gene segments sequencing showed genetic diversity three types sea rich neighbor joining tree shows genetic relationship samples adjacent sea areas closer demonstrates gene characteristics sea different sea areas obvious genetic diversity analysis pcr used rapid method geographical discrimination
technological innovation capabilities cloud platform implementation construction management context still primary objective study validate model assessing relationships among information platform usage technological innovation capabilities capital facility project performance study also evaluated moderating role type platform relationships study empirically investigated sample projects taiwanese construction industry structural equation modeling sem approach used validate research model testing moderation effect two way analysis variance anova used findings indicate implementation information platform significantly technological innovation capabilities addition analyses suggest technological innovation capabilities positive effect project performance results also show relationship information platform usage technological innovation capabilities depends type platform traditional cloud based information management platform indicates association technological innovation capabilities project performance strongly evident projects use cloud platform
background intestinal gel therapy efficiently improve several motor non motor symptoms advanced parkinsons disease recently developed movement disorder society sponsored unified parkinsons disease rating scale mds improved original making robust tool evaluate therapeutic changes however previous studies used mds unified rating scale assess efficacy objectives aim determine mds detect improvement experiences daily living following year treatment methods prospective multicenter open label study consecutive patients undergoing treatment enrolled patients examined twice prior initiation months later impact related symptoms assessed mds results non motor experiences daily living part mds improved median interquartile range iqr points median iqr motor experiences daily living ameliorated median iqr points median iqr health related quality life measured also improved median iqr median iqr points total score decreased median iqr median iqr points conclusions far authors aware paper first evaluate impact means changes mds confirm treatment efficiently improve experiences daily living advanced elsevier ltd rights reserved
incidence degenerative aortic valve diseases increased along life expectancy population although conventional aortic valve replacement gold standard symptomatic aortic stenosis procedures proven valid therapeutic option high risk patients aim study compare procedures high risk cohort methodswe retrospectively analyzed symptomatic high risk patients logistic fulfilling aortic valve implantation indications patients operated implementation procedures performed matching age logistic left ventricular ejection fraction pairs patients evaluated comparing difference groups survival kaplan meier analysis log tank complication rates stroke acute renal insufficiency atrial fibrillation implantation addition quality life differ groups patients group lower mean gradients postoperatively compared group high risk patients procedure comparable conventional advantageous results support expansion low intermediate risk patients
patients rheumatoid arthritis ankylosing spondylitis increased cardiovascular morbidity mortality arterial stiffness independent predictor events aim study assess arterial stiffness inflammatory markers patients short duration chronic arthritis assessed carotid femoral pulse wave velocity augmentation index traditional risk factors inflammatory endothelial markers chronic arthritis patients healthy controls find differences controls respectively versus versus controls respectively versus versus groups arthritis patients active disease significantly elevated inflammatory markers compared controls correlations endothelial inflammatory markers parameters arterial stiffness arthritis patients analyzing arthritis patients according median significant differences inflammatory endothelial markers found patients short duration active arterial stiffness increased furthermore association markers systemic inflammation arterial stiffness
semantic memory influenced individual differences conditions distraction question addressed observing participants recalled visual target words drawn single category ignoring words members either different single category working memory capacity related disruption synchronous asynchronous presentation distraction greater words presented subsequent experiments found greater negative priming among individuals higher dependent targets comparable category less dominant category members target recall impaired relative among individuals low results highlight role cognitive control resources target selection individual specific cost implications cognitive control
nonlinear adaptive filtering techniques system identification based model widely used identification nonlinearities many applications correspondence improved tracking capability numeric variable factor recursive least squares algorithm presented first order second order time varying systems environment nonlinear system tracking problem converted state estimation problem time variant system time varying kernels governed first order markov stochastic difference equation upon state space representation system built comparison conventional fixed factor recursive least squares algorithm algorithm provides better channel estimation channel tracking performance terms minimum mean square error mmse first order second order systems algorithm adapted time varying signals using updating prediction error criterion accounts signal demonstrated simulation results manifest proposed method good adaptability time varying environment also reduces computational complexity
spin emerging technology novel advanced functionalities enabled integration magnetic optical electronic properties onto semiconductor based devices article reviews possible implementation convergence concepts group core materials mainstream particular describe rapid pace progress achievement action notable case based special attention pivotal role played optical investigations advancing understanding rich spin physics group materials finally recent developments towards monolithic integration new class spin based light emitting devices prospects applications fields cryptography
hereditary angioedema hae patients experience recurrent local swelling various parts body including painful swelling intestine life threatening laryngeal hae literature attacks located one anatomical site though mentioned hae attacks also involve multiple anatomical sites simultaneously detailed description multi location attacks currently lacking study investigated occurrence severity clinical course hae attacks multiple anatomical locations hae patients included clinical database recombinant human inhibitor studies evaluated visual analog scale scores filled patients various symptoms various locations symptoms scores attack analysed data eligible attacks patients analysed thirty three patients symptoms multiple locations unrelated regions time first attack five simultaneously affected locations reported observation severe hae attacks often affect multiple sites body suggests hae symptoms result systemic rather local process currently believed
facial expressions always attracted considerable attention form nonverbal communication visual applications movies games people tend interested expressions rather regular expressions since ones deliver emotions paper propose automatic method facial expressions motion captured data certain personality type facial expressions generated using mapping transforms facial motions motions individuals identical conceptual mapping individuals personality type facial expressions needs considered type indicator popular method classifying personality types employed define personality type based experimentally validated simulations facial expressions
repeat expansion common genetic cause familial amyotrophic lateral sclerosis frontotemporal dementia study determined frequency repeat expansions different motor neuron diseases amyotrophic lateral sclerosis als motor neuron diseases affecting primarily first second motor neuron hereditary whereas studies repeat expansions published far rely polymerase chain reaction based screening applied polymerase chain reaction based techniques southern blotting furthermore determined sensitivity specificity southern blotting repeat dna derived cell lines repeat expansions found familial als patients sporadic als patients hereditary patients patients motor neuron diseases affecting clinically primarily either first second motor neuron found correlation repeat length age onset somatic instability repeat observed cell lines compared dna derived whole blood patient therefore caution warranted repeat length determination cell lines elsevier inc rights reserved
purpose renewable energies promoted order reduce greenhouse gas emissions depletion fossil fuels however plants renewable electricity production incorporate specifically higher amounts materials rated potentially scarce therefore question mineral resources contribute overall resource consumption manifold impact assessment methods recommended cover accurate complete investigation resource use renewable energy technologies methods life cycle assessment conducted different renewable electricity production technologies wind biomass german conditions compared fossil electricity generation coal fired power plant focus given mineral resource depletion technologies consensus reached far impact assessment method recommended different established recently developed impact assessment methods cml swiss economic scarcity potential compared contribution mineral resources overall resource depletion potential scarcity identified results discussion overall resource depletion electricity generation technologies tends dominated fossil fuel depletion therefore renewable technologies reduce overall resource depletion compared coal fired power plant comparison fossil electricity generation coal mineral resource depletion increased wind solar power investigated methods rate different materials major contributors mineral resource depletion used photovoltaic plants swiss gold copper incorporated electrical circuits cables cml nickel swiss stainless steel production however methods lack characterization factors potentially important materials conclusions mineral resource use investigated technologies using wider spectrum potentially scarce minerals practitioners need choose impact assessment method carefully according scope check important materials covered research needed overall assessment different resource compartments
background rapid increase extended spectrum beta producing bacteria potential health hazard development antimicrobial resistance animal pathogens serious implications human health especially strains transmitted human study antimicrobial resistance due producing pseudomonas aeruginosa meat investigated methods study meat samples healthy two major egypt collected following culture agar suspected aeruginosa colonies confirmed system aeruginosa isolates identified double disk synergy test additionally antimicrobial susceptibility testing producing aeruginosa isolates done antimicrobial drugs carried disk diffusion method genotypes determined polymerase chain reaction according presence results pseudomonas aeruginosa isolated meat sample total percentage producing aeruginosa meat isolates results revealed highest resistance followed prevalence rates beta genes recorded per tem conclusions study illustrates presence high rates aeruginosa represents increasing risk transmission human opens door current future antibiotics therapy failure livestock associated aeruginosa growing disaster therefore attention fully given livestock associated bacteria try find way human beings
experimentally known oxygen evolution reaction similar rather low question whether widespread computational models based adsorption thermodynamics capable reproducing observations making use dft results revised six different codes various types show whereas consistently predicted low predicted large new methodology based adsorption energy scaling relations shows inaccurate prediction stems anomalous adsorption energies oxygen including explicit water using account van der interactions modifies appropriately adsorption energies oxides predicted highly active
hepatitis virus hbv infection considered risk factor clinicopathological characteristics non non hepatocellular carcinoma hcc excluding past hbv infection investigated study aimed clarify clinicopathological features strictly defined hcc hcc patients underwent surgical resection affiliated hospitals japan negative serum anti hbv core surface antibodies addition hbv surface antigen anti hepatitis virus antibody without signs autoimmune liver disease disease patients divided alcohol intake positive group ethanol intake day non alcoholic fatty liver group ethanol intake day group ethanol intake preoperative clinical parameters tumor background liver pathology prognosis analyzed fibrosis detected patients respectively approximately alcohol intake positive patients advanced fibrosis non alcoholic fatty liver hcc subjects highest body mass index prevalence diabetes none mild fibrosis group hcc patients lowest incidence accompanying hepatic inflammation fibrosis largest tumor size recurrence survival rates comparable among groups fibrosis risk factors hcc regardless past hbv infection ethanol consumption present results also indicate possibility independent hepatic inflammation fibrosis ethanol intake past hbv infection
big data era process large scale data stream one existing challenges feature extraction method attracted much attention effectiveness data classification traditional classification algorithms take less advantage labeled samples information online learning sample problems also hot topics recently solve problems novel algorithm named semi supervised incremental feature extraction algorithm proposed paper first extract feature unsupervised way propose semi supervised subspace learning algorithm taking advantage class information adjust nearest neighbor weights third combine unsupervised semi supervised feature extraction approaches obtain objective function order solve sample learning problem experiments carried machine learning datasets university california datasets real world face image datasets faces rendered face demonstrate proposed algorithms process large scale data stream classification experiments using spark skill parallel computation environment performed comparisons related semi supervised feature extraction methods experiment results computational complex comparison demonstrate proposed algorithm obtain good performance copyright john wiley sons ltd
water scarcity consumption patterns rapid global population increase consumption ratio several factors necessity systematically access utilize supplementary importantly renewable water supply resources moreover application suitably designed maintained rainwater harvesting systems within context built environment focus diverse building promoted promising resolution systemic issues despite numerous positive benefits utilizing rainwater harvesting means supporting sustainable development green built environments exists gap properly integrating design features deliver congruent sustainable outcomes accurate design configuration simulation localization imposing proper maintenance schemes expected followed order accomplish ultimate goal executing rainwater harvesting systems besides inevitable noteworthy role governments educating providing prospects supporting decentralized water supply consumption systems encouraged ultimately paper provides overview contemporary rainwater harvesting systems respective implications systematic configurations quality assessments potential merging green roofs green built environment criteria eventually manipulated government regulation provide insights overcoming aforementioned rainwater related concerns
study sought prospectively predict aggression romantic relationships college students united states females males course two months set risk protective factors including personality characteristics rarely examined population accounting prior dating aggression verbal aggression predicted uniquely aggressive attitudes emotion regulation females physical aggression predicted aggressive attitudes low levels emotion regulation interaction traits emotion regulation gender males low levels traits less physical aggression reported greater emotion regulation findings among first show personality traits emotion regulation prospectively predict partner aggression late adolescence suggest mechanisms continuity interpersonal aggression early adolescence adulthood foundation professionals services adolescents published elsevier ltd rights reserved
autism heterogeneous multifactorial disease results interaction genetic vulnerability environmental factors several studies showed many genes play role autism component signaling networks regulate growth synaptic plasticity play important role etiology autism associated like gene member superfamily synaptic adhesion proteins encodes scaffold protein called involved interaction neuron clusters channels highly expressed nervous system development study association gene polymorphism autism investigated two hundred patients autism healthy individuals included study genomic dna extracted peripheral blood cells genotypes analyzed polymerase chain reaction restriction fragment length polymorphism pcr rflp statistical analysis performed using software genotype frequencies controls values patients autism respectively frequency alleles patients controls respectively results study showed significant association gene polymorphism autism studied population however obtain definitive conclusion larger studies patients controls needed confirm results elsevier ltd rights reserved
background investigated differences prevalence neuropsychiatric symptoms characteristics according disease severity patients early onset alzheimer disease methods recruited patients subdivided participants groups based presence absence clinical dementia rating scale compared differences neuropsychiatric inventory scores according disease severity results percentage patients group steadily increased rating increased total score significantly higher patients groups contrast association group frontal lobe functions associated groups stratification group prevalence appetite significantly higher patients group patients significantly higher prevalence hallucinations sleep disturbances group found statistical difference frequency symptoms patients without conclusion results confirm prevalence individual nps cognitive functions associated differ according severity
requirement prioritization considered crucial towards development successful high quality software nowadays software development project people software industries confronted challenge implementing large scale complex dynamic software applications hence need use requirement prioritization technique able deliver right set requirement seems crucial available techniques still suffer several weaknesses motivate identify comprehensively limitations future directions existing requirement prioritization techniques study conducted depth software engineering based systematic literature review helps execute thorough fair literature review due predefined review protocol gathered list requirement prioritization techniques investigate limitation weaknesses one technique findings study later used design new effective efficient requirement prioritization technique
moral decision making linked empathy present study built previous work examining relationship psychopathy autism spectrum disorder asd two conditions associated deficits empathy decision making students scoring high self report measures psychopathic autistic traits presented novel task judgments compared low trait control groups study replicated classic finding direct links agents actions harm victims mitigated decision making also found participants made decisions outcomes involved extreme physical versus everyday social harm enhanced decision making observed scoring high either psychopathic autistic traits although high trait groups reported experience less discomfort low trait counterparts verbal reasoning differences observed high autistic trait group high psychopathic trait group typically used explore decision making describe extreme hypothetical events involving physical serious emotional harm present findings suggest limit existing literature tendency make decisions considering everyday
transcriptome analysis key area biological inquiry decades years research field progressed candidate gene based detection rnas using northern blotting high throughput expression profiling driven advent microarrays next generation sequencing technologies revolutionized providing opportunities multidimensional examinations cellular high throughput expression data obtained single base resolution
non steroidal anti inflammatory drugs used alleviate pain therapy also assumed interfere associated pseudo inflammatory reactions particular effects partially selective cox inhibition constitutively expressed cox periodontal cells tissue induced remain unclear investigate possible adverse side effects potentially useful beneficial effects therapy examine underlying cellular tissue reactions randomly assigned male rats three consecutive experiments animals cone beam computed tomography histology reverse transcription quantitative real time polymerase chain reaction three experimental groups control tooth movement first second upper left coil spring daily oral dose vitro stimulated human periodontal ligament fibroblasts pressure without vivo significantly reduced serum reactive protein concentration tooth movement velocity induced root resorption osteoclast activity relative expression inflammatory osteoclast marker genes within dental periodontal tissue presenting good gastric tolerance vitro observed corresponding significant decrease prostaglandin interleukin rankl expression mediated inhibiting prostaglandin synthesis seems mediated inflammation rankl induced consequently tooth movement velocity thus limiting suitability therapy however protective effects regarding good tolerance profile suggest future prophylactic application merits investigation
current computer programs intracellular recordings often lack advanced data management usually applications also difficult adapt new experiments addressed shortcomings suite electrophysiology applications intracellular recordings programs use component object model technologies available microsoft windows operating system provide enhanced data storage increased interoperability aware applications easy data acquisition analysis thanks based integrated programming environment data files extensible organized integrated windows using structured storage technology data transfers programs facilitated implementing automation standard distributed allows write event driven acquisition analysis programs language within scripts reuse components available programs machines create distributed meta applications paper describes main features package used determine effect atypical antipsychotic drug synaptic transmission neuromuscular junction elsevier rights reserved
guiding attention emotional responses little girl surroundings film explores human existence face death informed philosophy vein article investigates difference fear death fear dead
concrete special type concrete high porosity use concrete achieve many potential leed green building rating system credits objective paper investigate appropriate mix proportion provides high leed points also good mechanical properties nine mix proportions based possible leed points examined replacement cement fly ash coarse aggregate recycled aggregate used properties concrete relating leed credits design values permeability void content compressive strength splitting tensile strength evaluated found proposed concrete achieve stormwater design quantity control recycled content recycled materials credits according results mix proportions cement replaced fly ash highest leed credit points also provided sufficient mechanical properties therefore mix proportions recommended green construction
test exercise myocardial perfusion imaging exercise mpi risk large artery chronic cad related ischemic stroke exercise mpi related data prior without previous stroke registered prospective follow performed document defined acute onset neurological symptoms mri findings non type absence atrial fibrillation sources years documented cis sds cis non sustained transient block exercise cis predictors threshold specificity identification future risk groups formed according cut significantly different free survival exercise mpi provide risk stratification markers
idiopathic pneumonia syndrome inflammatory disorder lungs occurs often fully allogeneic hematopoietic stem cell transplantation severe associated high year mortality rates despite existing therapies canonical nuclear factor signaling pathway previously linked several inflammatory disorders lung including asthma lung allograft rejection never specifically targeted novel treatment approach however report kappa kinase antagonist bay compound highly potent specific inhibitor kappa pathway able improve median survival times recipient described mouse model compound impaired production proinflammatory chemokines within host lung transplantation resulted significantly lower numbers donor lung infiltrating cells reduced pulmonary inflammatory cytokine production allograft compound beneficial effects appeared specific limiting pulmonary injury drug unable improve outcomes haplotype matched murine model recipient mice lethal acute graft versus host disease gastrointestinal tract collectively data suggest targeting canonical kappa pathway small molecule antagonist represent effective novel therapy specific management acute lung injury occur allogeneic american society blood marrow transplantation
wind energy generated wind power renewable clean available many places world energy generated wind turbines wind captured connected turbine drives electrical generator use source generate electricity commercial scale began international oil crisis european countries became interested development alternatives production electricity sources seeking reduce dependence oil coal use wind power generate electricity drawbacks however uncertainties generation difficulty planning operation power system several models wind power forecasting using artificial neural networks presented promising results paper presents use ensemble approach improve results obtained models using artificial neural networks specifically reservoir computing reservoir computing new paradigm offers intuitive methodology using temporal processing power without training main issue using ensemble approach consideration accuracy diversity individual predictors constitute ensemble
study rotary valve system automotive engines carried many years recent researches already successfully implemented idea none design provide variable valve timing flow area control simultaneously therefore variable valve control system proposed paper system design dynamic analysis proposed first presented moreover selection proportional integral derivative pid controller parameters valve control based emerging artificial intelligent technique search also discussed experimental simulation results show proposed tuning method better traditional method proposed variable rotary valve control system feasible
using qualitative research one organization undertook green building examine processes occur foster support new initiative among people diverse values perceptions found framing particularly important framing occurred due variation individuals cognitively connected different frames together overcome organization used interactive process define frame decoupling frames identified separated prioritized new language frame selected collective organizational goal develop concept frame decoupling describe variations cognitive diagnostic framing stakeholders within organization contribute framing resolved interactive processes effectively various preexisting frames frame decoupling additional frame alignment strategy social movements organizations use motivate support action organizational goals
purpose test hypothesis differences dna double strand breaks repair fidelity underlies differences materials methods primary fibroblast culture derived pediatric cancer patient treated reduced radiation doses consequent family history chromosomal fragility syndrome compared normal control dna repair fidelity studied southern blotting hybridization specific fragments repetitive sequence representing overall capacity genome restriction fragment chromosome repair fidelity results although assays showed statistically significant difference two cell strains residual mis mis residual damage lower enriched genome assay compared assay respectively conclusions results suggest comparison classic repair experiment assay measuring dna repair fidelity provide better resolution accurate estimate radiation induced dna damage underlies genomic instability increased
describe genetic transformation tissue fungus isolated species using agrobacterium tumefaciens mediated transformation uses resistant gene green fluorescent protein selection agents dna integration fungal genome assessed pcr southern blotting transformants examined stable analysis dna flanking sequences thermal asymmetric pcr tail pcr demonstrated disrupted genes transformants similarities conserved domains proteins involved antibiotic biosynthesis pathways library transformants generated transformants antibiotic activity staphylococcus aureus important human pathogen protocol described using useful identification analysis fungal genes controlling pathogenicity antibiotic pathways moreover protocol used reference species genus first report describe agrobacterium mediated transformation tool mutagenesis
social jet lag term describing social biological times article argued currently used formula social jet lag captures also sleep resulting sleep deprivation proposed adopt sleep corrected formula social jet lag takes form difference sleep onset free days case subjects longer sleep later equal sleep onset free days compared takes form difference sleep offset free days subjects longer sleep earlier equal sleep offset compared free days
malignancy major cause death patients inflammatory disease risk individual malignancies altered inflammatory diseases rheumatoid arthritis psoriasis study aimed examine malignancy incidence patients psoriatic arthritis psa related inflammatory disease institutional cancer registry medical record linkage systems retrospectively reviewed population based incidence cohort patients psa age sex matched malignancy rates compared using adjusted cox models incidence overall malignancy excluding hazard ratio confidence interval breast cancer significantly elevated psa cohort age female sex similar predisposing risk factors cohorts overall incidence malignancy risk breast cancer higher patients psa general population
examine associations recent intimate partner violence ipv reproductive frequency use reproductive sexual health services cross sectional survey administered year old women seeking care five family planning clinics evaluated associations recent experiences ipv ipv recent care seeking pregnancy testing emergency contraception sexually transmitted infection testing using multinomial logistic regression sixteen percent respondents reported ipv reported past months four percent respondents reported ipv recent without ipv associated increased odds seeking one aor multiple pregnancy tests aor multiple tests aor using emergency contraception aor multiple times aor recent ipv without associated increased odds seeking one aor multiple pregnancy tests aor using emergency contraception aor combined effect recent ipv increased odds seeking multiple pregnancy tests aor using emergency contraception multiple times aor seeking testing aor multiple times aor frequent requests pregnancy testing emergency contraception among young females seeking care indicator greater risk recent alone combination ipv
mexican male female transgender united states suffer serious health issues attributed stressors related transgender ethnic minority socioeconomic status study explored stressors resulting health issues needs particularly vulnerable population psychological evaluations examined multidisciplinary research team using systematic document review process review identified stressors occurred mexico united states verbal physical sexual unstable environments fear safety security status economic insecurity health issues resulted part stressors include posttraumatic stress disorder depression anxiety sleep issues isolation avoidance drug alcohol use suicidal tendencies despite suffering multiple health issues rarely sought health social services health promotion practitioners play important role serving silent minority expanding community based research focused intersection transgender ethnic minority socioeconomic status using trusted community members connect population necessary resources providing communication training resource development health care providers creating network service organizations understand needs transgender
paper new single phase flux reversal machine design increased power weight ratio described technique electromagnetic calculation based solving problems developed construction
identifying genes pathways contribute differences traits key goal psychiatric research despite considerable success identifying quantitative trait loci associated behaviour laboratory rodents causal variants genes challenging long time main obstacle size encompass tens hundreds genes however recent studies exploited mouse rat resources allow mapping phenotypes narrow intervals encompassing genes review studies rodent resources used highlight insights traits provided date discuss see biggest challenge field translating biological knowledge experimentally validating functionally characterizing candidate genes propose genome editing system holds key overcoming obstacle finally challenge traditional views versus resources light recent resource technology developments
potential electric power generation marine tidal currents enormous tidal currents recognized resource exploited sustainable generation electrical power high load factors resulting fluid properties predictable resource characteristics make marine currents particularly attractive power generation advantageous compared renewable energies moreover international related climate control triggered development renewable ocean energy technology therefore several demonstration projects tidal power scheduled capture tidal generated coastal currents regarding emerging promising area research paper reviews marine tidal power fundamental concepts main projects around world also report issues regarding electrical generator topologies associated tidal turbines moreover attempts made highlight future issues index emerging technologies mainly according relevant works carried wind turbines ship
aim aim study examine sports injury pattern establish cost injuries relation training competitive players national sports school methods one year prospective observational study recruited year old students obtaining informed consent participants requested report injuries pain disabilities occur within study period september august either training competition injured students seek treatment researcher made weekly visits followed accordingly return full training details progress injuries documented visit results sixty three injuries recorded soft tissue sprains strains commonest injury one third injuries occurred lower limb especially followed back injuries injuries require training modification half injuries training within one week upon full training half still symptomatic injury risk injury rate injuries player training hours conclusion injuries mostly involved lower limb almost overuse injuries occurred lower limb however injuries whole predominantly sprains strains overuse nature widely believed
aim study improve thermal conductivity thermal stability mechanical properties ester addition ester composites containing various ratios prepared thermal stability thermal conductivity samples evaluated thermogravimetric analysis differential scanning calorimetry laser flash method respectively samples characterized analysis gel content water absorption capacity stress strain test samples determined contact angle measurements moreover surface morphology samples investigated scanning electron microscopy obtained results prove ester composites good thermal mechanical properties used many applications electronic devices materials engineering emergent copyright john wiley sons ltd
ethyl studied possible two representative including aeruginosa growth curves chlorophyll content protein content levels oxidative stress apoptosis rates measured two exposure different concentrations results showed changes chlorophyll content protein content consistent cell density sensitive aeruginosa results oxidative stress indicated induced generation malondialdehyde mda enhanced activities antioxidant enzymes including superoxide dismutase sod peroxidase catalase cat two explore toxicity apoptosis rates toxin levels measured two different degrees apoptosis rates observed two apoptosis rates increased increase concentration intracellular extracellular affect presence aquatic ecosystem stimulate synthesis release cause serious water pollution pose threats human health results useful assessment guiding rational use pesticides agriculture
information communication technology ict applied increasingly supporting human immunodeficiency virus hiv prevention treatment technological advances extended field hiv self management objectives paper examine design use hiv self management programs identify knowledge gaps existing practice provide recommendations future research program development systematic review conducted search english literature published prior august six electronic databases inclusion criteria also included either quantitative qualitative assessments hiv self management programs utilized least one ict platform program protocol search identified six studies conducted australia united states studies diverse sample site enrollment criteria study population major functionalities ict platforms mobile phones websites included delivering information modules sending medication supporting self monitoring medical adherence risk behavior reduction enhancing communication among participants providing easy access hiv self management information major challenges faced self management programs utilizing lack interaction concern privacy hiv self management programs employed ict platforms limited number geographic coverage programs also tested initial stage small size samples minimum technical innovation lack explicit guiding theories models information behavior technology use observed studies use hiv self management interventions emerging field future research benefit paying attention technical innovation interactive features applying ict platform self management programs platforms increasing innovation connecting people places serve powerful tool reduce disparities health care health promotion future research also needed explore feasibility applying ict platforms self management programs serving populations diverse socioeconomic background resource poor settings elsevier ltd rights reserved
natural circulation primary coolant plays important role removing decay heat station black accident reactor core decay heat removal systems cooling lead based reactor order study natural circulation characteristics primary coolant reactor vessel air cooling system primary heat cooling crucial safety lead based reactors three dimensional cfd model china lead based research reactor clear built analyze thermal hydraulics characteristics primary coolant system cooling capability two systems abilities two cooling systems different decay heat powers discussed results demonstrated decay heat removed effectively relying either two systems however appeared obvious thermal stratification phenomenon cold pool besides increase decay heat power natural circulation capacity primary coolant two systems significant difference cooling system stronger respect mass flow primary coolant average temperature difference cold pool hot pool elsevier ltd rights reserved
parenting chinese culture central topic debate whether western derived parenting style applicable chinese cultures terms behavioral profiles relationships child adolescent adjustment study identified subtypes chinese maternal parenting style examined stability changes transition early adolescence urban chinese sample girls four waves longitudinal data collected adolescents fifth years sixth grades latent profile analysis identified four subtypes parenting style average level undifferentiated strict adolescents mothers exhibited best overall adjustment adolescents mothers showed worst adjustment adolescents strict mothers generally adjusted mothers except showed lower academic achievement strict parenting represented culture specific subtype parenting style chinese culture latent transition analysis revealed high stability parenting styles early adolescence transitions subtypes also evident findings highlight importance chinese parenting examining developmental course parenting style
examined impact daily supplementation vitamin deficiency function falls female long term care residents initial vitamin deficiency associated greater functional decline increased fall risk despite guideline recommended supplementation highlighting importance preventing vitamin deficiency elderly institute medicine guidelines recommend vitamin daily older adults maintaining serum optimal skeletal health adequacy guidelines sustaining function reducing falls elderly unknown female long term care residents aged enrolled osteoporosis clinical trial included analysis participants classified based baseline levels deficient deficient women provided initial vitamin weekly weeks supplemented vitamin daily months annual functional assessments included activities daily living instrumental physical performance test gait speed cognition mental health used linear mixed models analysis functional measures logistic regression falls daily supplementation maintained levels participants groups demonstrated functional decline women initially deficient greater decline physical function months larger increase cognitive deficits months compared sufficient baseline despite supplementation sufficient levels guidelines adequate elderly study optimal levels maintaining function preventing falls needed
background play major role detoxification high expression marker stem cells many organs including lungs common polymorphism gene results inactivation enzyme associated alcohol flushing syndrome increased risk cardiovascular alzheimers diseases cancers effect polymorphism lung stem cells thoroughly examined methods examined association allele lung function parameters population healthy individuals also examined association incidence asthma copd patient cohorts used vitro colony forming assay detect effect polymorphism lung epithelial stem cells primary human surgical samples transgenic mice response acute chronic lung injuries compared wild type mice results humans allele associated lower fvc general population development asthma copd bronchial lung epithelium carrying allele showed tendency lower colony forming efficiency compared allele mice epithelial thickness nuclear density number basal stem cells significantly lower adult mice electron microscopy showed significantly increased number morphologically abnormal mitochondria mice lung cells showed higher ros levels fewer functional mitochondria mice significant differences detected lung epithelial stem cells examined vitro exposed chronic cigarette smoke mice resistant development whereas influenza infection caused epithelial damage mice mice conclusions polymorphism several subtle effects lungs similar changes observed normal aging suggesting premature lung aging effect
background suicide violence often occur general population mentally individuals studies however assessed whether suicidal behaviors predictive violence risk mental illness aims aim study investigate whether suicidal behaviors including suicidal ideation threats attempts significantly associated increased violence risk individuals schizophrenia method data analyses obtained clinical antipsychotic trials intervention effectiveness trial randomized controlled trial antipsychotic medication adults schizophrenia univariate cox regression analyses used calculate hazard ratios hrs suicidal ideation threats attempts multivariate analyses conducted adjust common confounding factors including age alcohol drug misuse major depression antisocial personality disorder depression hostility positive symptom poor impulse control scores tests discrimination calibration assessed incremental predictive validity suicidal behaviors prediction violence risk results suicidal threats attempts significantly associated violence males females schizophrenia little change following adjustment common confounders suicidal threats however associated significant increase incremental validity beyond age diagnosis comorbid substance use disorder recent violent behavior conclusions suicidal threats independently associated violence risk males females schizophrenia improve violence risk prediction authors published elsevier open access article license http creativecommonsorg licenses
background recent studies shown early antiretroviral therapy art initiation results significant hiv transmission reduction rationale behind test treat policy world health organization implementation policy lead increased incidence art related adverse effects especially sub saharan africa region yet ready cope challenging issue main body introduction widespread use art drastically changed natural history hiv aids exposure art leads serious medication related adverse effects mainly explained mitochondrial toxicities situation get worse near future indeed art associated increased risk developing cardiovascular disease overt diabetes insulin resistance lactic prevalence disorders already high situation exacerbated implementation new recommendations countries characterized extreme poverty weak health systems inadequate low quality health services existing health facilities lack qualified health personnel lack adequate equipment medicines heavy workload context double burden disease additionally dearth data incidence predictive factors art related adverse effects anticipate strategies put place prevent occurrence conditions properly estimate upcoming burden prepare adequate response plan required anticipate effectively prevent upcoming burden conclusion first region experience huge benefits implementing test treat policy region yet prepared manage increased burden art related toxic metabolic complications urgent measures taken fill become consequences test treat policy
background avian antigen common cause hypersensitivity inhalation challenge serum extract hypersensitivity reaction patients related hypersensitivity antigenic components materials yet fully elucidated method serum intestine serum samples patients patients summer type patients lung healthy volunteers among protein spots found serum reacted sera patients identified mass spectrometry using recombinant protein performed confirm identified protein cytokine production peripheral blood mononuclear cells pbmcs stimulated recombinant protein also assessed results immunoglobulin lambda like polypeptide identified spots serum patients exhibited higher levels serum igg antibody recombinant compared control subjects stronger pbmcs proliferative response cytokine production pbmcs patients exposure indicated protein induce prone immune responses increase tnf alpha absence elevated production conclusions identified antigen present serum
background psychosocial distress common among cancer patients significant associations coping social support distress quality life adult cancer patients identified little known distress medical coping social support adolescents young adults objective aims study investigate prevalence psychological distress chinese cancer examine associations among distress anxiety depression medical coping social support population methods total patients recruited study patients completed chinese version national comprehensive cancer network distress hospital anxiety depression scale medical coping modes questionnaire social support rating scale results prevalence psychological distress chinese cancer scores highest year old patients scores positively correlated anxiety depression negatively correlated medical coping social support conclusion prevalence psychological distress cancer patients higher general cancer population medical coping social support lower prevalence psychological distress cancer patients implications practice findings suggest need evidence based intervention strategies enhance medical coping social support cancer patients nurses crucial implementing psychological interventions cancer patients
avian origin influenza virus cause concern china spring infections resulted acute respiratory distress syndrome severe form acute lung injury contributes morbidity mortality study induced viral infecting wild type deficient mice influenza results suggested close association motif chemokine ligand expressions induced lethal virus strain levels also detected confirmed human cases bronchoalveolar lavage fluid infected mice moreover overexpressed lung tissue infected mice importantly deficiency ameliorated induced mice determined weight loss survival rate wet dry ratio lung pathology taken together findings demonstrate essential virus infection thus potential therapeutic target influenza
annual average rainfall coastal area rainwater harvesting rwh practiced long time drinking water supply household rwh capacity storage tanks varies model type storage tanks provided several rwh programs government optimum storage tank volume investigated considering family size demand roof types rainfall result households water rainwater tanks six months rest year depend unreliable distance sources aim developing comprehensive decision support tool reliable rwh system design curves storage volume developed three climatic conditions dry average wet years available roof catchment area rainfall loss factor household demand typical six members family using mass curve moreover based daily water balance model developed assess reliability currently used water tanks analysis showed currently used tanks insufficient meet year long drinking cooking water demand average dry climatic conditions achievable reliability significantly varies increase catchment area tank size maximum achievable reliability large quantity water lost water even tank size water used purposes larger tanks used capture excessive water
site construction regarded effective means improving construction quality efficiency adoption slower developing countries china developed countries research barriers inhibiting sectors growth inadequate paper aims investigate major factors inhibiting adoption reference chinese construction market thirty factors influencing use identified literature review questionnaire survey face face interview professionals construction industry questionnaire sent developers china completed questionnaires retrieved ranking analysis used identify critical factors top three barriers absence government regulations incentives high initial cost dependence traditional construction methods factor analysis enables grouping critical factors five categories namely government regulations policies technological innovation industry supply chain cost market demand paper also indicates dominant five regulations policies findings provide valuable reference developers understand major barriers decision making government bodies aiming promoting construction industry put forward relevant policies incentives
increasing performance wider spread use automated semantic annotation entity linking platforms possibility using semantic information information retrieval keyword based information retrieval techniques shown impressive performance addition semantic information increase retrieval performance allowing accurate sense intent determination instance identification just name researchers already possibility integrating semantic information practical search engines using combination techniques using graph databases hybrid indices adapted inverted indices among others one challenges efficient design search engine capable considering semantic information need able index information beyond traditional information stored inverted indices including entity type relationships objective work paper investigate various ways different data structure types adopted integrate three types information including keywords entities types systematically compare performance different data structures scenarios data structure types adopted three types information different data structure types integrated storing retrieving three different information types report findings terms performance various query processing tasks boolean ranked intersection different indices discuss index type appropriate different conditions semantic search elsevier ltd rights reserved
health need competences promote healthy early parent infant relationships aims study explore whether differences groups health without additional parenting program education terms knowledge infant parent interaction observation assessment skills interactions cross sectional study included health certified therapists health without additional parenting program education health observation skills measured assessing five video recorded mother infant interactions questionnaire used measure intention self efficacy knowledge certified therapists health without additional parenting program education reported significantly higher mean level knowledge early relationship versus certified therapists health without additional parenting program education reported higher mean level knowledge infant self regulation versus latter group reported significantly higher need education versus compared health without parenting program education health certified therapists reported significantly higher frequency correct assessment mothers sensitivity two five video recordings compared video compared video respectively results present study support use video based education health increase knowledge skills assessing parent infant interactions randomized controlled trials needed determine whether improved level health knowledge observation skills assigned participation education program
study activated proposed degrade organic contaminants using model compound results showed higher removal rates compared alone alone activated process kinetic model regarding reactive species developed model fitted experimental data second order rate constants hydroxyl sulfate radical calculated respectively based relative rate technique substantially contributed degradation whereas contribution higher current density increased removal rates increased low current densities decreased high current densities particular degradation significantly enhanced increasing dosages affected iron solution turn led poorly removal rate alkaline conditions whereas natural organic matter dramatically inhibited degradation consuming radicals addition efficient removal rates para acid similar reaction conditions also confirmed results show promising ability system control water pollution caused organic contaminants elsevier rights reserved
negative health effects water pollution remain major source morbidity mortality china chinese government making great efforts strengthen water environment treatment however studies evaluated effects water treatment human health water pollution china study evaluated association water pollution health outcomes determined extent environmental regulations water pollution lead health benefits data extracted china health longitudinal study random effects model random effects model applied study relationship health water pollution mediator model used estimate effects environmental water treatment health outcomes intensity water pollution water pollution negatively associated health outcomes common pollutants industrial wastewater differential impacts health outcomes effects stronger low income respondents water environment treatment led improved health outcomes among chinese people reduced water pollution mediated associations water environment treatment health outcomes results study offer compelling evidence support treatment water pollution china elsevier ltd rights reserved
need accurate knowledge complex dynamical behavior high performance systems led development vast amount nonparametric system identification approaches recent years aim paper compare several proposed methods based experiments physical complex mechanical system bridge gap identification theory practical applications industry basic identification approaches often norm typical practical implications operation closed loop control multivariable coupled behavior nonlinear effects included analysis finally possible approach fast reliable identification illustrated based measurement results interventional medical ray system published elsevier ltd
vascular adhesion protein also known sensitive amine oxidase copper containing amine oxidase catalyzes oxidative primary one endogenous substrate recently described although mechanism action vivo completely understood suggested play role immune cell trafficking making target interest autoimmune inflammatory diseases much enzymology performed around target conducted absorbance fluorescent formats limitations high throughput screening subsequent compound profiling authors present use assay originally developed monoamine oxidase enzymes high throughput format used related given substrate similarity authors also demonstrate compatible different sources purified recombinant overexpressed live cells journal screening
consider problems computing maximal minimal non empty longer text length minimal problem show every tau tau exists linear space data structure tau query time tau preprocessing time sample application show data structure used compute decomposition text tau time number distinct factors decomposition maximal problem give linear space structure query time preprocessing time words simultaneously achieve optimal query time optimal construction time elsevier rights reserved
experiments atomic scale simulations suggest transmission plasticity carriers amorphous crystalline mediated interface amorphous crystalline layers paper present model describes defect interactions amorphous crystalline interface model based effective temperature framework achieve unified description slow atomic rearrangements phases driven equilibrium show second law thermodynamics density defects rate rearrangements apply framework dislocations crystalline solids shear transformation zones amorphous materials effective temperature formulation enables interpret observed movement dislocations production interface diffusion disorder across material demonstrate favorable agreement experimental findings reported demonstrate acts sink dislocations source
leadership style competency many industries nursing practice settings similar positive influence follower engagement teamwork experienced leadership employed administration faculty guiding framework nursing education impact embedding teamwork culture basic nursing education significant students ultimately nursing profession research needed develop test application leadership framework nursing education
challenge precise positioning using smart materials hysteresis limiting positioning accuracy model based delayed relay operator hysteresis modelling introduced model identified experimental data input function ensuring information input levels paper presents issues respect hysteresis compensation using model showing procedure follow avoiding pitfalls identification inversion issues due discrete nature model discussed specific linear interpolation method tested experimentally showing effective avoidance excitation dynamics smart material experimental results hysteresis compensation presented showing approximate error reference measured displacement consequences insufficient discretization level high frequency reference signal illustrated showing significant deterioration hysteresis compensation performance
construction random important step screening process available construction methods include asymmetric pcr separation lambda pcr amplification key step main drawback pcr amplification increasing nonspecific hybridization among different products products cause loss potential high quality inefficient screening even screening failure cycle number optimization pcr amplification main way avoid fundamentally eliminate nonspecific hybridization decreased cycle number lead insufficient product amounts developed new method asymmetric emulsion pcr overcome shortcomings conventional pcr asymmetric emulsion pcr different templates separated emulsion particles allowing single molecule pcr template separately amplified nonspecific hybridization avoided formation products observed method simple direct amplification cycles provide high quality library therefore asymmetric emulsion pcr improve screening efficiency systematic evolution ligands exponential enrichment authors biotechnology applied biochemistry published wiley periodicals inc behalf international union biochemistry molecular biology inc
help new design tools manufacturing integrated solutions generated concurrently consider function process based design pattern matrix solution elements developed realize product function systematically utilizing manufacturing induced properties developed manufacturing integrated product solutions refined using computer aided methods feature based modeling information modeling product generated specifically tailored chosen manufacturing technology integrated information model allows introduced tools used throughout entire development process example linear flow split fit illustrates tools interact realize manufacturing potential resulting innovative product design
aim study determine whether allergy status characteristics common cold patients modify effects zinc acetate methodswe available individual patient data three randomized placebo controlled trials zinc acetate administered common cold patients used one stage two stage meta analysis estimate effects zinc resultsthe total number common cold patients majority females eighty percent fell age range one third patients allergies one stage meta analysis gave overall estimate shorter zinc acetate usage two stage meta analysis gave estimate reduction common cold duration estimates compared average duration three trials effect zinc modified allergy status smoking baseline severity common cold age gender ethnic group effects zinc acetate consistent compared subgroups overall estimates effect seemed applicable wide range common cold patients optimal composition zinc best frequency administration investigated given current evidence efficacy common cold patients encouraged try zinc treating
based ternary quantum logic circuit symmetric weak ternary quantum encryption schemes proposed first one rotation gate scheme constructed second view synthesis general transformation another one scheme proposed third according one scheme two scheme generalized controlled gate constructed generalized matrix case finally security schemes analyzed two concluded attacker correctly encryption key maximum probability thus better protect privacy users data moreover schemes integrated future quantum server architecture thus computational security users private information protected distributed computing environment
background poor educational achievement associated range psychiatric disorders several studies suggest due cognitive deficits disease onset reflect genetic risk disorder however specificity familial contribution cognitive deficit clear analysed lifetime educational achievement psychiatric patients diagnosed schizophrenia bipolar depressive disorder unaffected siblings method register based case control study patients schizophrenia patients bipolar disorder patients depression siblings matched eight population controls patients siblings controls compared highest educational stream completed results lower educational achievement present schizophrenia patients primary school completing primary school odds ratio completing secondary school completing academic education compared patients bipolar disorder depression siblings schizophrenia bipolar depressed patients showed primary secondary school siblings schizophrenia patients siblings depressed patients less successful educational achievement secondary school completing academic education schizophrenia siblings depressive disorder siblings conclusions educational primary school specifically related schizophrenia bipolar disorder depression moreover appears illness since found siblings results add evidence early cognitive deficits distinct feature schizophrenia phenotype
study examines school time program targeting elementary aged youth populations typically science fields primarily african american hispanic english language learner participants program aimed foster positive attitudes toward science among youth engaging growing plants water without soil participants attitudes toward science including anxiety desire self concept examined pre post survey data course program three separate sites data showed participants anxiety decreased desire increased male female participants program self concept increased female participants three sites change significantly male participants participants first language english spanish factor attitude outcomes primarily positive outcomes suggest useful educational platform engaging participants based programming year round particularly settings physical space climate conduct outdoor similarities positive attitude outcomes three sites despite differences format implementation background experience suggest program resilient variation context understanding aspects program facilitated positive outcomes varied contexts useful design future programs
empathy defined ability share understand others emotional state multi construct relies discrete psychological processes specific neural correlates psychological processes impaired mental disorders schizophrenia autism spectrum disorders borderline personality disorder mood disorders among disorders psychopathy mainly characterized lack empathy others distress associated amygdala hypo reactivity context doctor patient relationships clinical empathy also encompasses physicians ability communicate understanding emotional state patient however sharing emotional states elicit compassion fatigue burnout symptoms among physicians medical students reduce empathic capacities decline capacities indeed observed medical training perspective taking protect physicians negative effects allowing show sustained empathic concern interventions promote empathy among medical students target communication skills values communication skill depend values grow
present multi level formation model complex software systems previous works extract software systems software networks studies usually investigate software networks class level contrast works treatment software systems multi level networks realistic particular software networks organized three levels granularity represents modularity hierarchy formation process real world software systems importantly simulations based model generated realistic structural properties software networks power law clustering basis model structure software systems effects software design principles explored helpful understanding software evolution software engineering practices
decades research shown positive life events contribute remission recovery depression however unclear positive life events generated study sought understand personality strengths predict positive life events aid depression tested longitudinal mediation model meaning life lead increased positive life events turn decreased depression sample consisted adult participants different countries completed online surveys five higher levels meaning life predicted decreases depression months time increases positive life events mediated effects personality strengths depression months however months goal pursuit positive emotions driving forces behind meaning effects positive life events used interpret short term impact positive life events depression findings suggest potential meaning life interventions facilitate depression remission
study assesses two approaches combine observations active passive satellite microwave instruments soil moisture data assimilation system first approach labeled joint retrieval assimilation single soil moisture product simultaneously retrieved active passive microwave observations catchment land surface model second approach labeled separate retrieval assimilation separate soil moisture products retrieved active passive microwave observations simultaneously model approaches neural network used retrieve soil moisture passive microwave temperatures active microwave observations spatially distributed ensemble kalman filter used assimilation united states august september analysis skill assimilation approaches evaluated situ observations scan stations compared model open loop assimilation skill averaged across sites skill obtained assimilation experiments similar surface soil moisture average correlation anomaly correlation respectively metrics slightly better open loop correlation anomaly correlation root zone soil moisture estimates assimilation also slightly improved compared open loop average correlation average anomaly correlation locally differences skill values two assimilation experiments related differences skill retrieval products differences captured observation errors specified data assimilation elsevier inc rights reserved
paper shows results simulation high spectral efficiency modulation coding scheme msc consist modulation error correction code comparison high spectral efficiency schemes different radio link signal distortion ways proposed msc show close result comparison proposed msc showed faster performances degradation non ideal transmission conditions overall due inherent features like low envelope amplitude variation simple algorithm moderate hardware complexity msc applied high speed satellite radio effectively
machine learning continuing gain popularity due ability solve problems difficult model using conventional computer programming logic much current past work focused algorithm development data processing optimization subset research emerged explores issues related security research gaining traction systems employing methods applied secure environments one machine biggest benefits data driven versus logic driven approach also weakness data models rely influence systems address drift data distribution changes using training online learning work focused exploring resilience various machine learning algorithms data driven attacks paper present initial findings using monte carlo simulations statistical analysis explore maximal achievable shift classification model required amount control data
memory widely believed unreliable high confidence played role now dna men women relevant laboratory studies often reported weak relationship confidence accuracy memory sufficiently people including led remember events differently way events actually happened light evidence many researchers agree confidence statements made court law particular high confidence often express trial altogether confidence statements made time initial identification much opportunity memory contamination occur considerable body recent empirical work suggests confidence highly reliable indicator accuracy time fits theoretical models recognition memory appreciation fact protect identification reform proposed date
power amplifier end radio transmitter provides power receiving antenna amplifier energy emission link module also strongest non linear module improve efficiency extend battery life improve linearity improved data efficiency linearity efficiency class power amplifier good compromise widely used band power amplifier class presents selected work points impedance matching method achieve high efficiency discussed amplifier input loop impedance converting circuit transistor amplifier circuit design ideas output circuit impedance conversion circuit design important analog signal processing circuit class high power amplifier simulation experimental results show amplifier range similar gain mesh distortion rate low
although gas become important source natural gas problems associated water pollution producing high salinity wastewater membrane applied treat wastewater suffer due scale formation accordingly study focused use scale formation process treatment high salinity wastewater experiments performed using laboratory scale direct contact system seven different applied simplified synthetic wastewater results analyzed using simple theoretical model found abilities scale formation different different difference chemical structures attributed changes effect scale prevention moreover mechanisms flux decline seem different presence surface also internal pore blocking occurred operation dominant mechanism changed addition
background joint diseases characterized lack defined biomarkers since autoantibodies elevated damage associated molecular pattern released activated high levels found study investigated biomarker potential systemic local levels proteins assess joint inflammation joint destruction experimental model arthritis methods serum levels various cytokines monitored disease development interleukin receptor antagonist mice using elisa multiplex based immunoassay correlated macroscopic microscopic parameters joint inflammation bone erosion cartilage damage local expression matrix metalloproteinase mmp mediated cartilage damage ankle joints investigated immunohistochemistry addition local activated monitored vivo optical imaging using anti specific tracer activated results serum levels significantly increased mice correlated macroscopic joint swelling histological inflammation serum levels pro inflammatory cytokines correlate joint swelling addition early serum levels prognostic disease outcome later stage increased serum levels reflected increased expression within ankle joint visualized molecular imaging next inflammatory processes serum also correlated histological parameters bone erosion cartilage damage addition mice increased synovial expression showed increased cartilage damage mmp mediated expression vivo imaging activated conclusions expression mice strongly correlates synovial inflammation bone erosion cartilage damage potential systemic local biomarker arthritis assessing inflammation also assessing severity inflammatory joint destruction
woman presented least four manifestations virus infection including central nervous system vasculitis first years hiv infection evaluated cell responses given multiple occurred especially following immune antiretroviral therapy
paper explores effect video game content context experience cooperative behavior three research studies study cross sectional correlation study exploring relationship video game team play frequency pro social behavior study game content violent video game neutral video game game context single play team play design dependent variable cooperative behavior study single factor design experiment examines effect gaming experience cooperative behavior collaborative context main findings team play frequency positive correlation pro social behavior pro social video game exposure significantly predicted pro social behavior collaborative play found significantly increase cooperation violent neutral video games however level gaming experience tended moderate relationship collaborative play level cooperation elsevier ltd rights reserved
efficient parallel algorithm fractional reaction diffusion equation implicit finite difference method proposed paper parallel algorithm consists parallel solver linear equations parallel vector arithmetic operations parallel solver order solve linear equations efficiently new reduced system developed elimination method experimental results show parallel algorithm good agreement analytic solution parallel implementation parallel processes two eight core intel cpus times faster serial one single core
background stress related disorders involve systemic alterations including disruption intestinal microbial community given putative connections microbiota immunity neural function behaviour investigated potential induced gut brain signalling modulate impact stress host behaviour methods male mice treated orally days either lactobacillus vehicle subjected chronic social assessed alterations behaviour immune cell phenotype rrna sequencing mass spectrometry employed analyse faecal microbial community metabolite profile results treatment decreased stress induced anxiety like behaviour prevented deficits social interaction however alter development avoidance following social microbial treatment attenuated stress related activation dendritic cells increasing regulatory cells furthermore modulated effect stress faecal metabolites immunomodulatory properties exposure social altered faecal microbial community composition reduced species richness diversity none prevented stress related microbiota disruptions persisted vehicle treated mice weeks following stressor cessation conclusions data demonstrate despite complexity gut microbiota exposure single microbial strain protect certain stress induced behaviours systemic immune alterations without preventing dysbiosis work supports based interventions stress related disorders
eye injuries sustained sport comprise per cent injuries eye serious enough medical attention sought prevalence eye injuries sport easily assessed due lack participation rates studies report total numbers time period evidence proportion ocular injuries sport reviewed relative frequencies different sports compared qualitative manner sports greater numbers ocular injuries detailed common occupational injuries eye sports eye injuries considered preventable hierarchy action occupational risk detailed adapted use sports scenario available international regional national standards sports eye protection detailed provisions compared major function standards provide adequate protection hazard sport concerned detailed compared function energy transfer eye protection introduce additional secondary hazards instance sharp fragments impact introduce features wearing eye protection instance restricting field view impede playing sport provisions standards intended limit secondary hazards detailed compared need future work standards writing activities international standardization organization sports eye protection detailed
background aim study third ventricular defined population estimate incidence presenting features surgical treatment treatment related complications clinical surgical outcomes methods study consecutive primary surgeries performed university hospital time period results estimated incidence rate per million mean age years male female ratio common presenting symptoms headache reduced level consciousness impaired vision surgical mortality gross total resection achieved based intraoperative findings based postoperative imaging rate related complications statistically significant difference endoscopic surgery respect surgery related complications grade resection time follow patients able care conclusions due risk acute neurological deterioration sudden death surgical treatment recommended patients symptomatic study shows surgical resection performed fairly low risk good long term outcome
water distribution systems construction operation disposal processes contribute undesirable greenhouse gas emissions concentration atmosphere strongly associated global warming climate change order meet consequent challenge limiting emissions problem design formulated multi objective optimisation problem three objectives follows total design cost resilience emissions addition frequently considered conventional design intervention options new pipes pipe duplication replacement addition pumps tanks etc various water demand management interventions water efficient appliances domestic rainwater harvesting systems considered number different rainwater tank sizes water saving appliances provided different parts households evaluated methodology applied new york network problems output non dominated sorting genetic algorithm optimisation process pareto front containing optimal solutions terms three objectives analysed results obtained demonstrate using demand management technologies design lead similar cost resilience emissions cost savings cost savings emission reduction relatively significant demand management technologies led cost effective resilient climate change mitigating solutions compared conventional design
previous research found patients gamma variant increased risk intravenous immunoglobulin resistance disease previous studies revealed elevated gamma expression correlated susceptibility patients conducted research determine whether gamma receptors affect susceptibility treatment response coronary artery lesions patients activating gamma inhibitory gamma methylation levels seven patients four control subjects examined using enrolled total patients control subjects performed real time pcr determine expression levels luciferase assay gamma found considerable increase methylation gamma gamma patients undergoing treatment promoter methylation gamma inhibited reporter activity cells using luciferase assay gamma mrna expression levels found increase susceptibility formation resistance gamma mrna expression levels significantly higher resistant patients responded pre treatment period furthermore gamma mrna expression ratio considerably higher patients without gamma gamma demonstrated increased methylation levels patients underwent treatment gamma expression influenced treatment response patients gamma mrna expression ratio greater patients formation
compared earlier programming data structure experiences students perspective changes computers programming introducing theoretical computer science picture underlying computational models need addressed mathematical tools employed understand quality criteria theoretical computer science focus shifts proving several years tried make perspective transition students third year mandatory algorithms data structures computational complexity course concepts receiving extra attention work completeness one central concepts computer science dynamic programming algorithm construction method powerful somewhat students major difficulties attribute completeness tasks look similar different purpose algorithm construction exercises students immediately see usefulness concept hence motivation one issue one line completeness emphasize algorithmic aspects using typical tools teaching algorithms potential difficulties associated dynamic programming method based known difficult concept many ingredients dynamic programming solution problem dynamic programming completeness several new activities structured teaching differently forcing students think adopt practice concepts programming assignments student surveys show activities appreciated students evaluations indicate positive effects learning believe activities useful similar course approach improving course action research evaluation done using course surveys self efficacy surveys like grading protocols grades also interviewed teaching experiences
practice self directed learning important adult students allows learn effectively work family study set examine self directed learning characteristics present adult students study process case university relationship adult students perceived competence level self directed learning academic performance also investigated study adult students case university participated survey included likert type open ended response items eleven indicators self directed learning quantified indicators included goal setting time management management assignment preparation exam preparation note taking capability research capability class readiness technical readiness online class readiness stress management findings showed adult students perceived level competence self directed learning indicators direct indirect effect academic performance based findings case university new initiatives provision support terms self directed learning help adult students studies
essential nutrient human metabolism however studies conducted establish dietary recommended intake purpose study provide data inform intake level address analyzing intake young korean adults evaluating blood levels estimated balance selected subjects average age total subjects years men years women average daily energy intake men women addition daily intake men women intake subjects lower upper intake intake excretion urine retention amount retention rate selected subjects respectively significant difference men women except urinary excretion men women intake positively related intakes food energy protein fat carbohydrate also retention amount positively related intakes energy protein fat results show food intake energy intake important factors intake retention
study investigated effects enhanced simulation based inquiry learning grade students conceptual change science development science beliefs two experimental groups studied topics motion force using computer simulations different simulation guides one enhanced findings led following conclusions enhanced simulation based learning significantly reducing science misconceptions effective changing students mental models consisted multiple interrelated key concepts students beliefs speed learning construction knowledge strong predictors conceptual change learning outcomes mature students benefit interventions less mature beliefs interventions needed promote development students science beliefs inquiry learning
multiple function method new approach obtain multiple wave solutions nonlinear partial differential equations method one obtain multi soliton solutions hence paper using symbolic computation apply multiple function method construct exact multiple wave solutions dimensional soliton equation based application obtain mobile single wave double wave multi wave solutions equation addition employ straightforward algebraic hirota method construct multi soliton solutions reveal remarkable property soliton soliton collision approach investigate one two soliton solutions dimensional soliton equation using method explore particle like behavior elastic interaction solitons potential application optical communication systems switching devices
networking become major innovation driver internet things networks chips need effective cryptography hardware steep rise cost overall system security main challenges many application scenarios rather high throughput work present area optimized implementations lightweight block cipher presented cores protected side channel attacks using threshold implementation applies secret sharing different orders prevent implementation results show higher order protected core smaller unprotected aes core security level classic also proposed secure cores consume less percent power unprotected aes security proposed cores validated arguments practical test based leakage detection methods fact show first order protected core first order leakage secure million observations higher order attacks second order secure implementation exploited million observations
paper describes implementation automatic measuring system used acquire voltage drop gradually heated output without load help determine coefficient internal resistance thermo electrical generator coefficient one main characteristic gives valuable information output voltage generate two sides maintained different temperatures thermo electrical module tem manufacturers give constant coefficient value products measurements prove fact temperature dependent purpose research accurately investigate coefficient internal resistance values depending temperature determine performance using experimental results propose later create improved thermo electrical model
viral genome assembled novo next generation sequencing ngs data infected fungus confirmed via race method novel insect positive sense single stranded rna virus named virus genbank genome consists nucleotides excluding poly tail contains single large open reading frame orf encoding untranslated regions utr respectively genome organization end contains consensus organization like rna virus cysteine protease rna dependent rna polymerase addition two putative structural proteins located region poly tail end viral particles approximately diameter dispersal distinctive surface projections based phylogenetic analysis sequences clustered insect rna viruses two viruses three viruses suggested constitute new group insect rna viruses found stages lab detected abundantly abdomen fat body reproductive organs muscle interestingly replication increased dramatically days fungal infection conclusion novel insect rna virus found ngs data assembly virus provide insight interaction virus fungus host elsevier inc rights reserved
objective low testosterone levels men associated increased risk cardiovascular disease aimed identify association serum testosterone level premature coronary artery disease cad predictors young adult males methods cross sectional study consecutive male candidates coronary angiography unstable previous cad age years included serum levels free total testosterone demographic cardiovascular characteristics compared cad positive normal coronary subjects cutoff point low additionally relationships variables number affected vessels predictors cad assessed results study patients premature cad compared normal coronary subjects patients cad group significantly older versus years value higher rates diabetes mellitus value dyslipidemia value serum levels significantly lower cad group normal coronary subjects value rate subjects low increased number affected vessels value trend significant correlation score value value respectively adjustment confounders association low cad remained significant odds ratio confidence interval value conclusion low levels testosterone associated premature cad severity young adults
virus major pathogen single dominant gene present relative confers broad spectrum resistance refinement genetic maps gene region comprising ten candidate resistance genes ten candidate genes individually cloned agrobacterium based binary vector transformed three susceptible varieties two candidate genes exclusively expressed transgenic plants five genes also expressed non transformed controls northern blotting derived probe assessment infection virus inoculated plants span three growth periods comprising six eight weeks indicates either absence initiation infection slow spread plant lines initial appearance infection subsequent plant lines limited genome walk downstream form gene based sequence identity indicates promoter identity two varieties upstream downstream sequencing indicates presence methyl transferase like gene respectively instead amino acid transporter like gene upstream sugar transporter like gene downstream possibility resistance locus need consistent monitoring virus infection gene expression transgenic trees discussed
background inflammatory bowel disease ibd patients persistent symptoms despite minimal inflammation frequently described overlap ibd irritable bowel syndrome ibd ibs limited data available ibs impacts individual patient ibd study aimed evaluate prevalence ibd ibs investigate impact patient reported outcomes method performed cross sectional analysis within partners study bivariate analyses logistic regression models used investigate associations ibd ibs various demographic disease factors patient reported outcomes including anxiety depression sleep disturbances pain interference social satisfaction results participants included total reported coexisting ibs diagnosis prevalence ibd ibs cohort similar within disease subtypes diagnosis ibd ibs associated higher use compared ibs diagnosis crohns disease versus ulcerative colitis colitis versus quality life measured short inflammatory bowel disease questionnaire lower patients ibd ibs compared without ibd ibs diagnosis associated anxiety depression fatigue sleep disturbances pain interference decreased social satisfaction conclusions sample patients ibd high prevalence concomitant ibs diagnosis observed ibd ibs diagnosis associated increased use adverse patient reported outcome appropriate diagnosis treatment counseling help improve functional status ibd ibs patients decrease use
fracture risk assessment tool developed centre metabolic bone diseases evaluate fracture risk patients based patient models integrate risk associated clinical variables bone mineral density bmd femoral neck clinical risk factors included chosen include established independent variables related skeletal fracture risk tool acquired worldwide acceptance despite several limitations models included biochemical estimation fracture risk due lack validation large prospective studies recently increasing number studies showing relationship occurrence fractures frequent electrolyte abnormality measured clinic serum sodium concentration reproducible affordable readily measurement thus think studied biochemical risk factor skeletal fractures prediction particularly hip carries greatest morbidity mortality achieve require collection large patient cohorts diverse geographical locations include measure serum sodium addition variables large numbers sexes wide age range wide geographical representation also require inclusion data duration severity information required risk fracture associated occurrence length exposure relationship risk variables included also independent effect occurrence death increased
diverse perspectives science promote innovation creativity represent needs diverse however many science fields lack gender diversity although fewer women men pursue careers physical science technology engineering mathematics women men pursue careers behavioral science current work measured relationship first year college students stereotypes science course completion science fields next years careers associated self direction self promotion agency working others side behavioral science careers associated greater degree agency women completed lower proportion courses men gender disparity disappeared women perceived high opportunity men pursued behavioral science courses lesser degree women disparity exist men perceived ample opportunity agency behavioral science results suggest highlighting nature nature behavioral science pre college settings promote greater gender diversity across science fields
background currently technology called used development crops resistant inhibit enzyme acid synthase first enzyme biosynthetic pathway produces chain essential amino acids leucine therefore multiple copies gene interest breeding programs targeting resistance work characterization gene accomplished cultivar cloning sequencing southern blotting conducted determine number gene copies results presence multiple copies gene shown previously several species described six copies gene confirmed southern blot analyses variants showed highest homology mrna sequences found database third copy shared similar fragments suggesting duplication chromosomes pairing conclusions presence multiple copies gene shows gene duplication common feature species evolution addition knowledge first report interaction sub genomes production hosting elsevier rights reserved
problem development alternative cells provides flexibility immune system crucial initiation appropriate effector mechanisms protect various pathogens bacteria viruses tumors parasites method study review research epigenetic regulation cell subsets results studies epigenetic modulation cell subset function dysfunction past years increased understanding alternative effector populations arise identity maintained clonal expansion conclusions recent advances epigenetic research within field immunology also raised questions immunology regulated pregnancy early life epigenetic regulation immune system prenatal development related diseases later life autoimmunity allergy
background antisocial personality disorder aspd researched mental disorder systematic reviews policy documents identify aspd priority area treatment research scarcity available evidence guide clinicians policymakers intervention established treatment choice disorder based treatment psychotherapeutic treatment specifically targets ability understand mental states others ability shown compromised people aspd aim study discussed paper investigate whether effective treatment alleviating symptoms aspd methods paper reports sub sample patients randomised controlled trial individuals recruited treatment suicidality self harm borderline personality disorder study investigates whether outpatients comorbid borderline personality disorder aspd receiving likely show improvements symptoms related aggression offered structured protocol similar intensity excluding components results study found benefits aspd associated behaviours patients comorbid bpd aspd including reduction anger hostility frequency self harm suicide attempts improvement negative mood general psychiatric symptoms interpersonal problems social adjustment conclusions appears potential treatment consideration aspd terms relatively high level acceptability promising treatment effects
production commonly equal sharing power decision making service user service provider bringing valuable different assets process experts experience lie overlap conceptually created providing services now virtue used services previous related studies suggest involvement production impact positively social capital self esteem self efficacy life skills however studies explicitly psychological phenomenological nature theoretical basis outcomes remains phenomenological study explored psychological impact production young people paid experts experience young persons mental health large diverse urban area looking psychological impact theoretical semi structured interviews conducted convenience sample five males mean age years phenomenological analysis yielded three master themes production approach professional identities transition participants valued organisational approach empowerment agency equality experts experience experts leading positive impact self efficacy self esteem production impacted fundamentally identity structure enabling explore new identity professional results framed within identity process theory point potential benefits model production
previous studies exploring athletes affective experience within competition neglected multivariate nature construct affective states purposes current study identify affective profiles competition examine key theoretical covariates perspective affective states perceived control stress predict membership affective profiles explore issue consistency change affective profiles individual time transition probabilities examine whether perceived control stress impact transition probabilities two hundred competitive athletes filled self report measures perceived stress perceived control intensity direction positive affect negative affect latent profile transition analysis revealed affective profiles whole low high moderate facilitators low high moderate low moderate athletes exhibited changes affective profiles time high moderate facilitators reported best psychological adjustment indicated effects covariates perceived control stress affective profiles perceived control stress significantly predicted transition probabilities athletes change affective profiles competition whole affective profile approach prove useful understanding affective states dynamic system implications intervention
background prevention sudden cardiac death implantable therapy icd accepted subcutaneous system icd promising terms reducing icd complications nevertheless impact novel generator position patients quality life qol yet unknown objective study aimed comparing qol posttraumatic stress systems methods icd case controlled single chamber icd patients asked respond three standardized questionnaires screening posttraumatic stress disorders ptsd detection predominant psychological disorders used screen potential mental comorbidities questionnaire used evaluate physical mental groups compared terms qol ptsd results pairs analyzed male mean age years prior appropriate inappropriate episodes ejection fraction underlying cardiac disease differ significantly groups revealed ptsd icd icd patients equally questionnaire icd icd patients fulfilled criteria major depression disorders icd anxiety disorders icd icd differ groups physical score patients icd compared icd patients mental score comparable groups icd icd conclusions case control study revealed equal even better physical patients icd ptsd occurred almost icd patients irrespective type system
use cases widely adopted software engineers model user system interaction however fragmented textual description functionalities inadequate user centered design concerns led human computer interaction professionals create methods techniques often opposite philosophy used software engineers modeling user system interactions therefore present paper proposes visual language use case description aiming improve support use cases user centered design common artifact communication human computer interaction software engineering communities obtain perceptions potential users visual language use cases description experimental study involving software development students professionals conducted copyright john wiley sons ltd
background induced humans animals fasting dietary interventions diets however increasing interest state motivated development alternative approaches rapidly increase using less drastic interventions tested whether oral intake beta beta mineral salt mixture increase wistar rats without dietary changes thereby useful model study effects alone metabolism methods beta orally administered provoke elevation effects intervention tested acutely gavage chronically weeks drinking water acutely concomitant glucose overload used suppress endogenous verify whether beta really absorbed long term administration allowed weekly evaluate impact blood glucose weeks body weight visceral fat mass lipid blood profile serum products results beta increased acute long term improved blood lipid profile raising hdl cholesterol concentration decreasing ldl hdl ratio reduced visceral volume mean correlated positively negatively volume serum products conclusions oral beta rapidly increase therefore used acute long term animal model long term treatment points important beneficial effects bodies serum lipid concentrations visceral fat mass results help explain metabolic adaptations following diets better body fat control serum lipid profile improvement
manuscript report synthesis nmr single crystal structures three linking related degradation one dimer special attention paid conformation order understand changes reaction statistical analysis database revealed similar stability cases various complicated unpredictable non covalent interactions play important role formation final order reproduce stable energy barriers separating full range two dimensional fully relaxed potential energy surfaces scans six linker calculated starting stable crystal structures scanned along bridge single bond torsional angles denoted theta theta internal coordinates optimized dft level gas phase energy optimized dft level gas ethanol solutions order evaluate really stable last relaxed scans performed local stable get reliable energy barriers method represents less time consuming reliable approach determination conformational stability bridging chains combination experimental statistical theoretical results shows observed conformation jointly determined energy levels energy barriers separating non covalent interactions somewhat randomness elsevier rights reserved
like software systems databases subject evolution time passes impact evolution vast change schema database affect correctness semantic validity surrounding applications paper performed thorough large scale study evolution databases part larger open source projects publicly available open source repositories laws software evolution established set observations typical software systems evolve last forty years served guide towards providing insights mechanisms govern schema evolution much like software systems found expand time stabilization mechanism constraints uncontrolled expansion maintenance time unlike typical software systems growth typically low long periods interrupted maintenance surprising lack complexity increase elsevier ltd rights reserved
objectives current paper aimed explore doctor patients views treatment practitioner health programme based service treating health professionals mental health addiction problems aims gain insights issues important patients consider whether service specifically doctors important helping overcome barriers accessing mental nine doctor patients attending took part semi structured interviews september june thematic analysis used explore patterns data written comments patients also participants reported difficulties finding appropriate treatment problems often severe time involved concerns confidentiality impact career obstacles help seeking important issues treatment analysis written comments provided support whilst needs mentally doctors mirror needs patients general supportive non attitude clinicians specific needs related confidentiality stigma
five experimentally characterized species end genome coding region encodes divergent proteins include like proteases poorly characterized domains involved regulation transcription processing virus host interaction present results bioinformatics analysis region species including related virus disease virus determined modified rapid amplification cdna ends race protocol combining profile profile comparisons phylogeny reconstruction identified association four distinct domain layouts major phylogenetic lineages domain gain including duplication loss early evolution specifically encodes highly divergent lacking catalytic residue encode finger domains conserved unexpectedly analysis revealed active virus known similar thus likely non show contrasting patterns conservation terminal respectively enriched conserved residues indicative different functional least conserved domain region size varied fold includes four copies novel motif potentially recognized domain containing proteins apparently lacks signal ribosomal coding region importance comprise family mammalian rna viruses include economically important pathogens knowledge family obtained characterization viruses five species virus hemorrhagic fever virus lactate dehydrogenase virus porcine respiratory reproductive syndrome virus porcine respiratory reproductive syndrome virus present results comparative genomics analyses viruses known species including related virus whose genome sequence completed study analysis focused multifunctional end genome coding region encodes proteins using diverse bioinformatics techniques identified many patterns evolutionary conservation specific members distinct species characterized novel groups likely associated structural functional determinants important virus replication virus host interaction
power power supply monitor control converters required circuits embedded systems mobile systems often need special power modes three functions control executed taking less current total traditional design techniques meet fatal area problem try reduce current increasing area design paper presents power management system designed cmos process system part cortex based microcontroller offers converter control functions regulated supply battery paper presents best published combination high precision variation trip voltages power consumption area number trip points observed
temperature variation semiconductor device operation significant affects contact resistance investigated paper reports improvements analytical modeling determining specific contact resistance including effect temperature technique extracting value using technology computer aided design modeling also demonstrated results obtained analytical models metal silicon contacts compared shows significance temperature small changes electron affinity hence barrier height due changes considered order obtain reliable analytical expressions
objective primary cultivation clinical specimens human cervical cancer main side population cells isolated biological characteristics analyzed methods clinical specimens human cervical tissue cultured get primary cells staining flow cytometry used sorting get main side population cells molecular biology morphology compared hela cells results primary cervical cancer side population cells isolated successfully two cells obvious tumor cell morphology beta integrin related markers expressed side population cells significantly higher main group cells distribution cytoskeleton expression associated tumor markers affected tumorigenesis two cells conclusion side population cells cultured isolated clinical specimens human cervical cancer characteristics tumor stem cell used study targeted therapy cervical cancer
important plausible impact changing global climate altered power generation dams project century global hydropower production forcing coupled global hydrological dam model three general circulation model projections run two emissions scenarios dams simulated using detailed model accounts plant specifications storage dynamics reservoir realistic optimized operations show inclusion features non trivial effect simulated response hydropower production changes climate simulation results highlight substantial uncertainty direction change globally aggregated hydropower production similar change mean global production high emissions scenario depending several clearly impacted identified prominent encompasses mediterranean countries southern europe northern africa middle east region hydropower production projected reduced approximately average end century high emissions scenario accounting dependence hydropower meeting current electricity demands countries emerge vulnerable similar loss total national electricity generation depending country countries central asia projected significant increase total electrical production similar without new power generation facilities elsevier rights reserved
almost research tested whether risk factors interact prediction future eating disorder onset suggest qualitatively distinct pathways accordingly prospective study tested possible interactions risk factors prediction binge eating eating disorders adolescents also examined sex differences pathways risk two analytical approaches used classification tree analysis ideally suited identifying non linear interactions optimal cut points defining risk follow random forest analyses two way interaction terms series logistic regression models data drawn western australian pregnancy cohort study population based study followed participants pre birth young adulthood study involved adolescents male developed bulimia nervosa binge eating disorder disorder late adolescence sex first potent predictor eating disorder risk females showing fold increase risk relative males males females weight eating concerns next potent predictor risk three risk groups emerged reflecting non linear risk females intermediate weight eating concerns externalizing problems emerged additional predictor interaction terms logistic regression models produce significant results correcting multiple testing findings advance knowledge risk pathways eating disorder onset highlight non linear risk processes provide cut points prospectively identifying high risk youth prevention programs published elsevier ltd
three dimensional printing materials engineering noninvasive diagnostic imaging computer aided design structural heart intervention cardiovascular applications technology development include use patient specific models medical teaching exploration valve vessel function surgical catheter based procedural planning early work designing refining latest innovations percutaneous structural devices review discuss methods materials used printing today discuss basic principles clinical image segmentation including multiple imaging datasets create anatomic model interest applications congenital heart disease coronary artery disease surgical catheter based structural disease printing new tool challenging image plan carry cardiovascular interventions american college cardiology foundation
power wire concept novel trend modern electrical systems hence system networks become sophisticated modeling longer easy task paper propose analytical analysis global modern electrical network explicitly develop analytical model evaluate differential mode impedance different sites complex network end use transmission line theory applied case cables cable parameters propagation constant characteristic impedance identified measurement via impedance analyzer parameters included analytical model computation process computed different sites compared time impedance line impedance stabilization network accordance standard assess model performance carried experimental test bench measured agree computed analytically
development water saving cultivation techniques attracting increased attention worldwide rainwater harvesting system known plastic film gradually become promising cultivation method rain fed ecosystems china however documented whether system practiced semi humid region irrigation available field studies comparing three cultivation patterns flat irrigated pattern across two different nitrogen rates two cultivars conducted two consecutive years assess potential role improving water use efficiency winter wheat dry semi humid region northwest china high soil moisture favourable temperature establishing period practice contributed emergence seedlings days earlier superiority also resulted longer growth duration also resulting earlier differentiation thereby increasing grain number per number per wheat yield practice compared highest yield achieved combined higher application condition practice resulted approximately yield treatment higher application increasing compared practices respectively addition practice comparison increased fertilizer productivity uptake efficiency respectively averaged across others treatment years highly recommend practices rate water saving technology promising strategy increase wheat yield current ecosystem northwest china elsevier rights reserved
health policy often discuss appropriate boundaries public funding interface public private providers organized regulated receives less attention paper discuss ethical regulatory issues raised interface three medical practice models care executive wellness clinics block fee charges physicians provide insured services whether publicly insured insured insured public requiring patients pay services non insured services physicians associates choice practice models different decision design insurance plan include exclude user analyze issues raised regards familiar health care values equity efficiency highlighting additional concerns fair terms access provider integrity fair competition analyze common canadian regulatory response block fee models considering extension wellness clinics regards standards governing physician patient relationship role informed consent close highlighting briefly issues common concern across different fundamental normative frameworks health policy
heterogeneous nanostructures dots embedded solid matrices core nanoparticles promising platforms wide variety applications including increased quantum yield solar energy conversion however characterizing controlling interfacial morphology defects greatly influence electronic properties proven difficult numerous cases carried calculations nano structured materials matrices embedded established interfacial core structures affect electronic properties particular showed defects present interfaces matrices give rise detrimental states degrading performance photovoltaic devices instead electronic gaps inverted system dots clean indicating material superior electronic properties solar applications addition calculations predicted core structure turn band gap tuned applying pressure matrix providing means engineering properties new functional materials
paper reviews recent literature factors influencing suicide behaviours including thoughts plans attempts immigrant cultural minority groups inform comprehensive understanding suicide behaviours increasingly culturally diverse populations thirty three studies published identified digital databases searches included review analysis study findings focused impacts cultural identity cultural immigration influences family community supports suicide behaviours policy practice research recommendations identified inform relevant suicide prevention efforts enhance mental health supports immigrant cultural minority populations
switched systems theory used analyze stability image based observers three dimensional localization objects scene presence intermittent measurements due feature tracking losses limited camera field view example generally observers filters exponentially stable persistent measurement availability error growth intermittent measurement loss even providing seemingly accurate state estimates constructing framework utilizes state predictor periods measurements available class image based observers shown exponentially convergent presence intermittent measurements average time total time condition satisfied conditions developed general form applicable observer exponentially convergent assuming persistent visibility utilizes object motion knowledge reduce amount time measurements available maintain convergence guarantees based stability results simulations provided show improved performance compared zero order hold approach state estimates held constant measurements available experimental results also included verify theoretical results demonstrate applicability developed observer predictor design compare typical approach using extended kalman filter
extracellular matrix ecm plays important role autoimmune mediated demyelinating diseases including multiple sclerosis experimental autoimmune encephalomyelitis integrin binding protein participates bidirectional communication ecm target cells affects transduction pathways maintain neuronal immune cell homeostasis biological activity also heavily influenced microenvironment stimulates cleavage changes functions study estimated expression profile neural tissues rats first relapse chronic relapsing investigated relationship play pivotal role zinc related cell homeostasis protection cns cytokine induced injury data showed rats mrna protein levels increased concurrently transcription within spinal cord rats higher content fragments low molecular weight untreated treated rats expression upregulated lymphoid cells multiple alpha beta neurons brain cortex white matter hippocampus cerebellum besides multiple cells expressed granular signals detected secretory vesicles alpha beta neurons patches adjacent plasma membrane zone findings imply demyelinating lesions generated proteolytic fragments interactions contribute tissue remodeling autoimmune attack author published elsevier ltd behalf ibro
murine models aggressive cell lymphomas generated date include chronic lymphocytic leukemia diffuse large cell lymphoma cell lymphoma models led improved understanding disease etiology cell biology importance tumor microenvironment despite efforts considerably little progress toward model marginal zone lymphoma accomplished herein describe similarities differences highlight effective murine models mimic disease two former informing potential model latter time writing review precise molecular events remain determined treatment regimen remains identified therefore based efforts put forth cell lymphoma field throughout past three decades established role cell biology oncogene tumor suppressor recurrent deletion loss many cancers make recommendations murine model
understanding human environmental health critical millions cope recurrent illness rely directly natural resources although studies examined environmental degradation infectious disease effects human health use environment remains unexplored human illness often assumed reduce human impacts environment logic people reduce time effort put thereby impact natural resources followed households living lake kenya four time points examine illness influenced using fixed effect conditional models control individual level time invariant factors analyzed effect illness effort methods illness among individuals listed primary occupation affected participation however among active fishers found limited evidence illness reduced effort instead fishers shifted methods fishers likely use methods illegal destructive concentrated areas required less travel energy fishers also less likely fish using legal methods physically demanding require travel deep waters considered sustainable altering physical capacity outlook fishers human illness shifted effort engagement natural resources sustainability actions findings show previously unexplored pathway poor human health negatively impact environment
accident nuclear power station march accident several investigation japan issued reports lessons learned accident including recommendations severe accident research review specific severe accident research issues began accident atomic energy society japan recently developed new thermal hydraulics safety evaluation fundamental technology enhancement strategy light water reactor safety improvement development accident thoroughly first version prepared revision made considering lessons learned accident time research expert committee evaluation severe accident established published phenomena identification ranking tables thermal hydraulics source term issues severe accidents based findings accident utilizing methodologies present paper reviews severe accident research accident lessons learned severe accident research accident severe accident research issues reviewed accident current severe accident research activities mostly based two mentioned reviews accident japan
intensity distribution inhomogeneous interference pattern received processing errors errors produced processing spatial spectrometer reduces accuracy transform spectrum inhomogeneous correction method interference pattern proposed analyzing producing mechanism characteristics existed interference pattern intensity spatial spectrometer according method actual interference pattern decomposed piecewise normalized solve light intensity distribution function transform spectrum fourier transform result reverse light intensity distribution function obtain correction spectrum lastly inverse fourier transform implemented corrected spectrum realize correction interference pattern correction method used measured interference pattern near infrared light spatial spectrometer results show method effectively improve homogeneity interference pattern intensity distribution inhibit edge frequency signal transform spectrum compared simulated ideal spectrum noise spectrum reduces noise spectrum reduces signal noise accuracy spectrum increased
dynamic response bearing load speed often determine performance limitations machines necessary able predict bearing dynamic performance integral part machine design analysis paper mathematical model developed investigate nonlinear dynamic behavior rotor bearing system due localized defects inner race outer race mathematical formulation contacts rolling elements inner outer race considered nonlinear springs whose stiffness obtaining using contact stress theory nonlinear damping also taken consideration cylindrical bearing governing equations motion formulated using energy approach contact force contact stiffness nonlinearity calculated using newton method unknown nonlinear simultaneous equation new mark implicit integration technique coupled newton method solve differential equations computer program developed simulate defect inner race outer race results represented time frequency domain equations motions solved using beta method phase plot map proposed mathematical model also compared experimental results radial axial load condition results obtained predicted model frequency spectrum phase plot various speeds mathematical modeling experimental results found quite similar
paper presents substantially simplified map theory proves consistency called assumption exists ordinal map theory lambda calculus plus epsilon operator set theory including foundation map theory one epsilon operator map theory one left computer programming language map theory original aim lambda calculus map theory suited reasoning classical mathematics computer programs furthermore map theory suited eliminating barrier classical mathematics computer science rather just supporting two fields side side map theory maps class maps map theory corresponds sets first map theory class maps much like power set along others new map theory synthetic sense class maps defined inside map theory rather introduced paper define notions canonical non canonical kappa kappa sigma expansions prove smallest strongly ordinal canonical kappa sigma expansions models proves consistency furthermore prove canonical expansions fully abstract models computational part map theory elsevier rights reserved
electricity generators varying capacities utilized nigeria alternative source power owing electricity supply national grid study evaluated impact emissions generating sets air quality human health selected areas city nigeria levels carbon monoxide carbon dioxide oxides nitrogen oxides nitrogen dioxide hydrogen methane monitored using portable copies questionnaire administered generator operators nearby residents collect additional information capacities sampled generators ranged range mean concentrations carbon dioxide methane ppm carbon monoxide ppm nox ppm methane ppm oxides ppm hydrogen ppm highest generator sites distance sample sites generator locations accounted variation pollutants levels frequently suffered exposed residents included nasal congestion cough headache fever national policy appropriate use electricity generator urgently needed nigeria
objective physical inactivity increases postmenopausal possibly premenopausal breast cancer risk although different biologic mechanisms proposed primary objective estimate breast cancer risk associated high versus low levels moderate vigorous recreational activity separately premenopausal postmenopausal women methods conducted systematic review literature published july included reports cohort case control studies relating moderate vigorous recreational physical activity metabolic equivalent breast cancer incidence exclusively premenopausal postmenopausal women study quality performed meta analyses using random effects modeling subgroup meta analyses based tumor subtype race body mass index parity hormone therapy use family history cancer statistical adjustment body dose response relations examined results pooled relative risks women higher versus lower levels moderate vigorous recreational activity premenopausal studies postmenopausal studies breast cancer respectively high heterogeneity inverse associations weaker among postmenopausal cohort studies studies statistically adjusted occupational household activity premenopausal postmenopausal risk estimates versus without body adjustment vary menopause status although subgroup effects menopause dependent among studies overweight obese women inverse association postmenopausal premenopausal breast cancer respectively dose response curves generally nonlinear conclusions although risk estimates similar premenopausal postmenopausal breast cancer subgroup effects menopause dependent
background health parents disabilities understood existing research used small non representative samples lack research using national representative data hindered advocacy policy making efforts objective present study used nationally representative data examine prevalence rates chronic physical health conditions among parents disabilities compared parents without disabilities methods analyzed pooled linked data medical expenditure panel survey corresponding national health interview survey conducted logistic regression analyses examine age adjusted health differences parents without disabilities controlling covariates outcome measures included obesity arthritis asthma cancer heart disease diabetes high cholesterol hypertension stroke results controlling model covariates adjusting age parents disabilities significantly higher odds aor ranging chronic conditions parents disabilities also significant higher odds conditions aor conditions aor conditions aor conclusions parents disabilities significantly poorer health parents without disabilities elsevier inc rights reserved
strain provides information local behavior structural components one concerned parameters structural health monitoring shm civil structures plays important role condition assessment bridges terms fatigue yielding structural material safety reserve reliability structural components etc wind structural health monitoring system deployed suspension bridge hong kong hitherto operated continuously years part strain installed bridge measure dynamic strain response based strain measurement data acquired structural condition evaluated addressing following issues evaluation characteristics stress responses structural members different deck cross sections comparison results obtained statistical analysis daily maximum stresses different members comparison design values designated stresses due live loads limit state ultimate limit state evaluation inner forces monitored structural members corresponding strength utilization factors assessment results obtained present study used reference guideline scheduling bridge inspection maintenance activities
joint injury causes post traumatic osteoarthritis approximate patients anterior cruciate ligament acl develop within decades injury yet mechanisms responsible development joint injury understood study examined whole joint gene expression rna sequencing day weeks post injury non invasive tibial compression overload mouse model mimics acl rupture humans identified genes differentially regulated injured contralateral joints includes known regulators osteoarthritis several new genes including also identified long noncoding rnas differentially expressed injured joints comparing data gene expression data generated using surgical medial model identified several common genes shared mechanisms study highlights several differences two models suggests model rapidly progressing model study provides first account gene expression changes associated development progression model authors journal orthopaedic research published wiley periodicals inc res
cyber physical systems used control chemical processes found manufacturing civil infrastructure energy industry transportation many places one common characteristic areas operation critical potential life threatening past attack cyber part systems lead physical consequences first known attack challenging develop countermeasures field without normal operation underlying system research goal detect attacks without interfering cyber physical systems way realized anomaly detection system using passive network monitoring approach based analysing state physical process interpreting communication control system system state compared model based prediction system serve solid base intrusion detection order realize intrusion detection system testbed built based widely used implementation consists three main parts first task understand network communication order gain information controlled process realized analysing deeply understanding publicly management protocol resulting protocol integrated widely used network security monitoring framework gathering information process state prolonged time creates time series time series second step statistical models physical process built predict future states final step new states physical process compared predicted states significant differences considered indicator compromise
recent years non invasive techniques evaluation small bowel playing major role management chronic intestinal diseases inflammatory bowel diseases ibd diagnostic performances magnetic resonance imaging computed tomography ultrasound field small bowel disorders assessed established two decades newer techniques strain shear wave put forward assessment disease activity characterization ibd related damage setting crohns disease gastrointestinal disorders data preliminary research clinical studies shown promising results regards ability techniques differentiate inflammatory fibrotic tissue distinction ibd activity inflammation ibd related damage fibrosis currently considered crucial assessment management patients moreover techniques currently considered setting intestinal disorders rectal tumors aim paper offer comprehensive narrative review non invasive techniques available assessment small bowel disorders particular emphasis inflammatory bowel diseases summary current evidence use techniques setting
introduction organizations successfully achieve mission objectives benefit competent effective management since important factor organizations survival success aim study determine influential determinants human resources development among health services senior managers method descriptive analytical research undertaken cross sectional study late sample included people among health services managers studied organization data collected questionnaire analyzed using spss software findings results showed influential determinants development senior health service managers consisted ideological innovation behavioral perception skill technical skills human skills decision making skill physical capabilities spiritual ability mental ability motivation attitude team work communication intelligence learning technical knowledge general basic knowledge importance mentioned determinants top management organizations significantly percent conclusion overall based results research important influential determinants lie ideological innovation behavioral areas accordingly recommended important determinants emphasized human resources development managers besides seeking activities performed based determinants
paper includes country level virtual water data environmental curve water pollution virtual water accounts total amount water required produce good stages production paper constructs water independence index defined water required domestic production divided amount water required imported goods results suggest increase trade openness water intensive goods lower water pollution levels
evidence human cerebellum involved motor control also cognitive functions several studies shown language related activation toward right cerebellar hemisphere people accordance cerebral cortical language general cerebral cerebellar activations terms behavior hand use activation cerebellum hand preference weakly associated language however known whether functional relations reflected anatomy investigated volumetric gray matter cerebellar mri data set comprising subjects tested cerebellar associations correlations cerebral cortical anatomical regions important language hand motor control defined two different automated image analysis methods brain supplemented extensive visual quality control significant associations cerebellar found significant associations cerebellar cerebral cortical found none correlations greater mostly method atlas dependent basis large highly powered study conclude overt structural manifestation cerebellar functional connectivity respect hand motor control language
given potential decisions workplace become increasingly important managers promote leadership positions inclined behavioral ethics research contributed effort examining array individual difference variables locus control play role morality however past research focused mostly direct causal effects much processes including mediation different factors especially morality based decrease choices purpose current research examine process includes conscious decision pathways moral decision making individual level findings study employing participants task reveal accurate ethical prototypes moral awareness situation decreased decisions moral found positively related constructs addition accurate ethical prototypes found partial mediator perceptual moral less moral awareness found partial mediator reflective moral less theoretical practical implications findings discussed
among emerging memory technologies resistive memories including phase change memory pcm spin transfer torque magnetic random access memory ram metal oxide resistive ram considered promising conventional dynamic ram build future main memory systems main memory databases benefit features low leakage power high density pcm good read performance low read energy consumption ram low cost architecture however also disadvantages long write latency high write energy limited lifetime bring challenges database algorithm design based memory systems paper focus design ubiquitous tree aiming make friendly present basic cost model based memory systems distinguishes reads propose detailed cpu cost memory access models search insert operations tree based proposed models analyze cpu costs memory behaviors existing friendly tree schemes find suffer three issues address issues propose three different schemes experimental results show schemes efficiently improve performance reduce memory energy consumption extend lifetime based memory systems
pancreatic adenocarcinoma devastating disease poor prognosis regardless stage date mainstay therapy advanced disease chemotherapy little incremental improvements outcome despite extensive research investigating new treatment options current practices continue containing combinations need novel therapeutic approaches mandated ongoing poor survival rates associated disease one approach include manipulation biogenesis stress response recently applied malignancies lymphoma prostate cancer promising results review focus current therapeutic options pancreatic adenocarcinoma complexities associated developing novel treatments particular emphasis role treatment strategy
background number studies association clock genes polymorphisms cancer susceptibility increased last years results often conflicting comprehensive overview quantitative summary evidence field available results literature search identified eligible studies comprising subjects cases investigating polymorphisms involving clock genes overall primary subgroup meta analyses gene variants performed study distribution tumor follows breast cancer prostate cancer pancreatic cancer non lymphoma glioma chronic lymphocytic leukemia colorectal cancer non small cell lung cancer ovarian cancer identified single nucleotide polymorphisms snps significantly associated cancer risk mixed breast cancer mixed breast breast clock breast breast breast breast cancer postmenopausal breast breast cancer postmenopausal breast cancer subgroups assessed level quality evidence intermediate also identified polymorphisms lower quality statistically significant associations conclusions work supports hypothesis genetic variation clock genes affect cancer risk findings also highlight need efforts research field order fully establish contribution clock gene variants risk developing cancer methods conducted systematic review meta analysis evidence association clock genes germline variants risk developing cancer assess result credibility summary evidence graded according criteria false positive report probability calculated validate result subgroup meta analysis also performed based participant features tumor type breast cancer subgroup stratified work conditions estrogen receptor progesterone receptor status menopausal status conditions associated risk breast cancer different studies
various industries automotive leisure show great interest physical agents hence study aims investigate effects absorption carbon dioxide nitrogen melt solubility interfacial tension using pressure volume temperature apparatus high pressure temperature combined magnetic suspension balance solubility carbon dioxide nitrogen melt measured temperatures degrees degrees pressures mpa solubility super critical fluids melt compared data theoretical values calculated equations state surface tension interface measured using drop shape analysis profile observed dependency interfacial tension temperature high pressures decreases reduction solubility high temperatures relationship interfacial tension density difference polymer supercritical fluid also examined using generalized equation elsevier rights reserved
obtain analytical expressions torques angular speed induction motor simple geometry resembling geometry first induction motor investigated rotor conducting disc rotating magnetic poles two axis space degrees apply results discuss theory ubiquitous electromechanical hour meter comparison theoretical result angular speed measurements propose simple experiment induction motor aluminum disc rotor constructed
south american atlantic one kind ecosystem considered biodiversity however last decades intensively reduced original surface water resources water quality one main goods services system provides people monitoring management recommendations present study focused determining nutrient content nitrate nitrite ammonium phosphate parameters temperature electrical conductivity turbidity dissolved oxygen total dissolved solids surface water mountain rivers analyzing human health risk assessing environmental distribution determined pollutants analyzing water quality indices min addition total bacteria dataset used literature turbidity total dissolved solids nitrite exceeded guideline value recommended national international guidelines several sampling stations spatial distribution pattern analyzed principal component analysis factor analysis pca showing defined groups rivers showed good adjustment rated water quality good excellent sampling sites therefore study suggests use min monitoring water quality region also water treatment total dissolved solids turbidity
previously found oxytocin receptor binding density medial amygdala correlated positively social interest motivation investigate male rats binding density central amygdala correlated negatively social interest female rats determined causal involvement sex specific regulation social interest adult rats antagonist side side social interest test min sex juvenile exposure blockade decreased social interest males females treatments behavioral effect explore sex specific involvement system social interest used vivo determine possible sex differences endogenous release social interest interestingly males females showed similar levels extracellular release baseline social interest suggesting factors local release mediate sex specific role social interest moreover found positive correlation release social investigation time females reflected reduced release social interest females expressed low compared high social interest discuss possibility reduction release consequence rather cause exposure social stimulus overall findings show first time extracellular release similar males females plays causal role regulation social interest toward juvenile males ibro published elsevier ltd rights reserved
aim present article derive exact integral equation green function model equation motion procedure like original papers though exact integral equation allow solve model represents strong constraint approximate solutions analogous sum rule already obtained literature use spectral moment technique think however equation motion procedure easily related historical procedure original papers also discuss examples possible applications sum rule propose analyse solution fulfilling used pedagogical introduction metal transition
purpose study investigated overactive bladder oab functions male patients used antidepressant drugs ads previously examined female patients based conflicting data literature regarding effects oab differences male female urinary system anatomical hormonal methods study included male patients control group healthy subjects experimental group patients taking ads different disorders patients completed overactive bladder validated oab questionnaire international consultation incontinence questionnaire short form beck depression inventory results oab scores antidepressant users significantly higher control group highest prevalence oab symptoms observed patients taking lowest prevalence patients taking moreover frequency oab antidepressant groups statistically significant univariate logistic regression analyses showed significant relationship presence oab antidepressant usage score age patient multivariate logistic regression analyses association presence oab antidepressant usage statistically significant conclusions present study showed incidence oab severity oab symptoms increased males using antidepressants various disorders due unique pharmacological effects molecular individual level serotonin inhibitors
aims patients often experience adverse events aes treatment overactive bladder refractory antimuscarinic agents investigated prevalence predictive factors aes patients methods total patients underwent injection age gender overactive bladder subtypes medical morbidities neurological diseases patients recorded maximum flow rate max volume post void residual volume voiding efficiency baseline analyzed identify adverse events within months treatment results acute urinary retention developed patients urinary tract infection occurred within months treatment large volume occurred patients months treatment respectively developed significantly often men patients years old baseline max greater incidence age years low max low voiding efficiency large baseline also risk factors adverse events conclusion large volume common aes treatment patients overactive risk developing aes injection informed possible aes wiley periodicals inc
idiopathic pulmonary fibrosis ipf chronic progressive debilitating disease unknown etiology leads death nearly half patients within years past years scientific community made tremendous progress towards standardized diagnostic prognostic algorithms led generation guidelines latest guidelines provided fundamental diagnostic algorithms set diagnosis majority cases however leave significant minority patients without diagnostic importantly therapeutic end current guidelines light research advances including tools time provide practical guidance real world ipf order address patients needs scope review article summarize challenges everyday ipf clinical practice make effort provide realistic answers patients questions elsevier ltd rights reserved
symbolic computation checking two research areas individual scientific focus sharing also common interests development implementation application decision procedures arithmetic theories despite two communities rather weakly connected aim newly accepted project csa strengthen connection communities creating common platforms initiating interaction exchange identifying common challenges developing common theory along way tools industrial applications paper report aims first activities project relevant challenges unified community
aimed examine treatment patterns patient reported outcomes pros benign prostatic hyperplasia patients overactive bladder oab symptoms hundred forty seven patients included prospective observational study primary endpoint describe medical treatment patterns patients oab symptoms secondary endpoint determine pros patients clinical outcome assessed using international prostate symptom score pros measured using related qol questionnaire korea qol dimension starting study patients received blocker monotherapy whereas received combination therapy patients completed month treatment patients still received blocker monotherapy still received combination therapy received subsequent addition blocker patients stratified storage higher voiding lower patients without although treatment groups reported significant improvement baseline significant group differences changes qol found one third patients received blocker monotherapy one third received combination therapy another one third received subsequent addition blocker storage higher patients without vice versa voiding similar improvement clinical outcomes pros observed treatment groups
purpose construction projects complex projects taking place dynamic environments necessitates accounting different uncertainties planning stage significant lack management tools repetitive projects accounting uncertainties construction environment purpose paper present algorithm optimized scheduling repetitive construction projects uncertainty design methodology approach fuzzy set theory utilized model uncertainties associated various input parameters developed algorithm two main components optimization component buffering component optimization component presents dynamic programming approach processes fuzzy numbers buffering component converts optimized fuzzy schedule deterministic schedule time protect schedule anticipated delays agreement index used capture users desired level confidence produced schedule sizing algorithm capable optimizing cost time objectives example project drawn literature analysed demonstrate capabilities developed algorithm allow comparison results previously generated findings testing algorithm revealed several findings fuzzy numbers utilized capture uncertainty various inputs without need historical data modified algorithm capable optimizing schedules different objectives uncertainty finally used capture users desired confidence final schedule originality value project planners utilize algorithm optimize repetitive projects schedules modelling uncertainty different input parameters without need relevant historical data
distributed generation technology spreading rapidly owing advantages clean environment loss reduction voltage improvement utilities pakistan generations increase supply capacity industries installing meet load requirements order reduce energy used supply power back utility even peak durations interconnection changes electrical network characteristics existing utility network protection problems occur form relay settings increased short circuit currents paper investigates effects interconnection short circuit currents site industrial area modeled simulated short circuit analysis analysis shows interconnection radial increases short circuit level nodes
paper presents development preliminary evaluation integrated group cognitive behavioral treatment cbt comorbid mood anxiety substance use disorders session treatment developed mental health program teaching hospital community based service administered settings results uncontrolled effectiveness trial treatment suggest integrated group cbt reduce stress alcohol use symptoms improve substance self efficacy changes symptoms anxiety depression drug use significant although effect size anxiety reduction medium range nonetheless clinical significance treatment effects mood anxiety substance use symptoms modest changes coping skills quality life significant although medium large effects observed changes several coping skills participants reported highly satisfied treatment found treatment strategies useful noted improvement functioning particularly socially methodological sample size limitations warrant rigorous follow investigations treatment results considered context current literature integrated psychological treatments common comorbidities elsevier ltd rights reserved
study aimed investigate effects dust harvested rainwater quality rainwater samples collected rainwater harvesting systems northern taiwan september april five one dust storm hit taiwan period harvested rainwater analyzed including electrical conductivity turbidity total organic carbon acute test concentration metals three results harvested rainwater dust storm showed higher turbidity normal rainwater conversely due strong dilution effect ion concentrations harvested rainwater lower normal rainwater addition harvested rainwater dust storm significantly different normal rainwater
ankylosing spondylitis chronic inflammatory disease characterized pathological inflammation however pathogenesis pathological relationship inflammation disease remain largely unknown mesenchymal stem cells mscs progenitor cells capable osteogenic differentiation recently demonstrated mscs patients greater potential osteogenic differentiation mscs healthy donors therefore seems component pathological previous studies indicated abilities mscs change following differentiation however subsequent effects abnormal osteogenic differentiation unclear demonstrated secreted monocyte protein osteogenic differentiation enhanced secretion augmented monocyte migration increased classical macrophage polarization enhanced tnf alpha secretion inhibiting secretion osteogenic differentiated using encoding short hairpin rnas ameliorated dysfunctions blocking pathway corrected abnormal osteogenic differentiation inhibited overexpression prevented subsequent monocyte dysfunction finally expression regulated osteogenic differentiation vivo locally augmented osteoblasts ossification sites patients summary study determined overexpression abnormal osteogenic differentiation triggers monocyte dysfunctions propose novel hypothesis pathological lead inflammation hypothesis contribute reveal precise pathological relationship inflammation field secreted abnormal osteogenic differentiation overexpression leads monocyte dysfunctions pathological lead inflammation
phthalate reproductive developmental animals suspected endocrine modulator humans widespread exposure general population patients additionally exposed containing medical devices metabolic knowledge humans vital toxicological evaluation also exposure assessments based human data secondary oxidized metabolites like mono ethyl phthalate mono ethyl phthalate mono ethyl phthalate mono phthalate valuable biomarkers exposure represent major share metabolites excreted urine four oxidized metabolites immune external contamination possibly ultimate developmental long half times elimination make excellent parameters measure time weighted body burden reflect short term exposure calculated daily intake general population children children significantly higher exposed adults exposures percentile day respectively limit values like reference dose day daily intake day considerable degree fold children give cause concern also detected significant exposures voluntary platelet donors dual needle technique premature neonates exposed times limit values depending intensity medical care median day percentile day
every evolution fluid uniquely described energy tensor true energy tensor describe evolution different fluids problem determining called inverse problem problem non deterministic solutions paper devoted solve inverse problem perfect energy class perfect fluids evolving local thermal equilibrium starting point previous result math showing thermodynamic fluids evolving purely hydrodynamic characterization characterization allows solving inverse problem compact form case perfect energy representing evolution ideal gases studied detail applications examples outlined
purpose purpose article analyze strengths limitations research designs studies implementing coping based training interventions adolescents methods quantitative mixed methods studies selected reviewed critical analysis strengths limitations validity concerns results methodological strengths weaknesses assessed major limitation studies reviewed selection bias quasi experimental studies randomized controlled trials practice implications improved coping strategies skills found participants coping skill training intervention programs decreased depressive symptoms less impact individual disease burden found treatment intervention groups
article using literature data method questionnaire survey method interview method mathematical statistics logical analysis institute physical education specially selected students research object sports institute specially selected students sports injury status investigated elective class students sports injury awareness sports injury incidence sports injury pathological conditions sports injury type sports injury parts movement injury reason analyzed detail basis puts forward prevention strategy sports injury great significance improving level training improving college training effect
research conducted within framework national science foundation sponsored summer research experience undergraduate students research considers small scale mathematical models simple one story structures subjected free base motion excitations installed without passive damping devices gain understanding dynamic behavior reviewing active semi active damping means applied researched today using computer programming numerical methods goal understand counteract catastrophic disasters structures caused research broken number matlab simulations experiments order understand basic dynamic control features required design earthquake resilient buildings experiments include free vibration experiments test stiffness columns different heights test natural frequency damping ratio one story structure different mass loads active control applied experimental system experiencing accelerations attributed robustness comparisons made control control control earthquake inputs fuzzy logic controller developed effectively control transient vibrations uniqueness control concept fuzzy control continuously varies damping characteristics semi active tuned mass damper concluded fuzzy logic based effective regular passive providing half settling times wiley periodicals inc appl
paper describes creation modelling tool nets means possible simulate processes enables vast tool support fields model check graphically oriented simulation software verification advantage process modelling nets formal description graphical display numbers tools nets modelling simulation market use created simulation tool nets possible model simulate consequently form processes running systems important aims designed tool create model visualize processes operating systems create appropriate models optimize progress educational processes implement rules processes first part concerned definition basic terminology fields modelling principles modelling simulation basic features nets implementation forming nets tools given strong tool model real processes means created tool possible model simulate processes operating systems educational processes possible model rules fuzzy nets
detection widely used fields computer graphics multimedia processing many computer graphics tasks image segmentation image labeling tracking rely accurate generation maps however current methods lack ability generate fine boundary background also providing high recall rate detection algorithm proposed paper based rectangular wave spectrum analysis method divide given image several regions using pre set rectangular wave template determine final value calculating difference region adjacent regions uniqueness compared entire image repeated tests using different data sets produced high accuracy recall rate moreover boundary map clear fine
successful quality software projects need able rely sufficient level security order manage technical legal business risks arise distributed development definition sufficient level security however typically captured implicit requirements rarely gathered methodological way unstructured approach makes work quality managers difficult often forces developers operate unclear undefined security state throughout project ideally security requirements elicited methodological manner enabling structured storage retrieval checking requirements paper report experiences applying structured requirements method list set gathered reference security requirements reported experiences gathered industrial setting using open source platform cooperation industry partners output work enables security quality conscious stakeholders software project draw experiences evaluate reference base line
processes received considerable attention degradation modeling last two decades paper propose generalized process degradation model takes unit unit variation time correlated structure measurement error considerations simultaneously constructed methodology series models studied literature limiting cases simple method given determine transformed time scale forms process degradation model model parameters estimated based maximum likelihood estimation method cumulative distribution function probability distribution function process measurement errors given based concept first time performance degradation failure time distribution also obtained finally comprehensive simulation study accomplished demonstrate necessity incorporating measurement errors degradation model efficiency proposed model two illustrative real applications involving degradation carbon film resistors wear sliding metal given comparative results show constructed approach derive reasonable result enhanced inference precision elsevier ltd rights reserved
arose early eukaryotic evolution structural components highly conserved simplest complex species recent years role vertebrate organs received increasing attention due correlation human disease dysfunctional particular presence developing mature kidney become deep area research due common kidney kidney disease interestingly mutations genes encoding proteins localize cause similar cystic phenotypes kidneys various vertebrates suggesting essential role kidney homeostasis importantly genes far identified kidney disease conserved functions across species whose kidneys include primary aim provide comprehensive description role kidney development highlight usefulness zebrafish embryonic kidney model understand function kidney health
background exercise beneficial depression less known impact post intervention physical activity sedentary behavior aim paper determine extent participation light moderate vigorous intensity exercise intervention influenced habitual physical activity sedentary behavior patterns depressed adults methods accelerometer data collected pre post intervention depressed participants randomized one three week intervention groups light moderate vigorous exercise mixed models examined changes time spent sedentary light moderate vigorous physical activity time accumulated sedentary number sedentary time results overall sedentary time decreased light activity time increased across intervention groups significantly light exercise intervention group reduced minutes time number activity moderate exercise intervention group reduced time number sedentary changes observed vigorous exercise intervention group conclusions exercise intervention led increase overall light physical activity decrease sedentary time though neither change statistically significant participation light moderate exercise intervention groups associated reductions time evident vigorous exercise intervention group authors published elsevier ltd
nosql especially graph databases constantly gaining popularity among developers promise deliver superior performance handling highly interconnected data compared relational databases apache reference implementation highly interconnected data model however relational database back end paper describe experiences graph database back end compare java alternatives querying data consider performance usability developers perspective results show good query language terms code moderate overhead queries however supplemented stored procedures make performance deficits pattern matching queries api slow whereas connection performs significantly better elsevier inc rights reserved
paper presents first pixel detector realized using technology process bipolar cmos devices mainly targeted automotive application silicon particle detector realized pixel sensor diode dimension support signal sensitivity pixel diode circuit simulations performed substrate voltage analog signal processing circuitry digital operation circuit designed supply voltage moreover analog processing part pixel detector circuit confined unit pixel diode sensor achieve fill factor first phase design array pixels passive diodes designed measured experimentally entire analog circuitry including passive diodes implemented single chip chip tested experimentally voltage capability evaluate suitability sensor omega substrate characterized laboratory cmos sensor realizes depleted region several tens characterization shows uniform breakdown irradiation approximate capacitance reverse bias voltage response radiation tested using radioactive sources ray tube
literature recent decades generating shift stepwise uniform process experience varies among individuals among notable developments empirical exploration complicated debilitating sometimes life threatening response death one testing novel interventions treat article provides recommendations identifying treating complicated
paper focuses field ontology evaluation visualization ontologies represent essential technology development semantic web applications technology proven useful range applications data manipulation administration paper introduces ontology visualization approach based descriptive vectors offers design descriptive vectors representation ontology domain also algorithm design generation descriptive vectors approach offers quick overview given ontologies content addition work presents design methods comparison evaluation various ontologies based descriptive vectors moreover introduces method ontology placing context within space map finally method administration user navigation space presented
denial service attack purely malicious commonly used network system making network resources unavailable legitimate users one attack target system enterprise whereby attacker large number malicious packets making unavailable legitimate users launch smart effective attack attacker makes priori assumption order effective reveal policies information attacker paper first present process used attacker system leisure collect information target collected information used attacker launch slow rate attack propose technique delay induced response utilizes underlying principle moving target defense cyber technique network frequently changes properties visible attacker order attacker discovering information policy primary objective attacker efforts discovering order specifically last matching rule also known default rule
interferon ifn associated development thrombotic including thrombotic syndrome reviewed literature earliest reported association july found cases analysis data shows mean age diagnosis years majority cases seen ifn used treatment chronic leukemia cml multiple sclerosis chronic hepatitis virus infection hcv one case cell leukemia syndrome cases reported polycythemia vera lymphoma sex distribution nearly equivalent exception patients multiple sclerosis female predominance reported data pooled analysis average duration treatment ifn diagnosed months comparative analysis showed patients required highest cumulative dose exposure developing months cml months hcv months cases confirmed type motif level measured showed presence inhibitor cases confirmed moderate severe thrombocytopenia striking clinical feature presentation consistent finding cases outcome analysis revealed complete remission persistent chronic kidney disease ckd patients treatment corticosteroids plasma exchange rituximab resulted durable responses elsevier rights reserved
rainwater harvesting ancient practice involves collecting storing using precipitation meet site water needs paper develops demonstrates guidelines sizing capacity storage tanks provide reliable continuous supply harvested rainwater residential households operation rainwater harvesting system simulated stochastic mass balance performed daily volume rainwater tank tracked determine maximum accumulated deficit monthly basis results summarized dimensionless charts showing minimum size rainwater storage tank needed meet water demands specified levels reliability authors published elsevier ltd
purpose evaluate feasibility outcomes nurse practitioner delivered program targets obesity real world primary care setting method small descriptive study conducted clinic low income patients sixteen adult participants obese attended individual primary care office visits occurring every weeks weeks healthcare provider delivered pre planned behavioral interventions visit data comprised health promoting lifestyle profile additional surveys physical measures results participants reported improvement health responsibility physical activity nutrition spiritual growth stress management motivation healthy living diastolic blood pressure declined systolic blood pressure body mass index declined non significantly conclusion additional research necessary determine success program time larger numbers diverse participants healthcare providers primary care practice sites elsevier inc rights reserved
study examined effect teaching english gestures iranian school students achievement speaking forty iranian learners participated study divided two groups one control group one experimental group two months teaching gestures done experimental group treatment gestures regarded treatment common tools nonverbal communication treatment gestures used determine effect students achievement speaking speaking placement test given experimental group control group pretest posttest according statistical calculations effectiveness treatment noticeable study suggests teaching english gestures effective technique teaching english however help students develop ways overcome communication problems moreover regarded natural responses situations
deep convolutional neural networks recently emerged dominant paradigm machine learning variety domains however acquiring suitably large data set training often significant challenge major issue remote sensing domain extremely large collections satellite aerial imagery lack rich label information often readily available image modalities letter investigate use land cover classification high resolution remote sensing imagery overcome lack massive labeled remote sensing image data sets employ two techniques conjunction transfer learning fine tuning data augmentation tailored specifically remote sensing imagery allows one bootstrap preserving deep visual feature extraction learned image corpus different image domain data augmentation exploits various aspects remote sensing imagery dramatically expand small training image data sets improve robustness remote sensing image data apply techniques known data set achieve land cover classification accuracies respectively
friction welding novel joining process extensively used welding aluminum alloys widely known process parameters involved friction welding play pivotal role determining final characteristics microstructure joint however still unclear combination process parameter values lead optimum joint characteristics technique efficient method widely used performing optimization manufacturing engineering paper joint friction welding performed process parameters optimized using orthogonal design experiments unlike previous studies optimization friction welding process aluminum alloys comprehensive approach taken towards number input output parameters process process parameters considered study tool rotational speed tool speed tool tilt angle tool pin shape optimum design obtained reference output parameters including hardness grain size center zone maximum working temperature joint tensile strength elongation vertical horizontal forces tool process analysis variance additionally performed evaluate significance design parameter output parameters results gained analysis variance indicated rotational speed speed critical parameters determining mechanical properties quality microstructure finally validate predicted optimum values based technique confirmation tests conducted excellent agreement observed predicted experimental values showing accuracy employed method obtained results
trees derivative products used societies around world thousands years contemporary construction buildings whole part suggests growing interest potential building wood scale previously wood significant building material grown natural inclination building wood good environment conditions really case environmental benefits using straightforward although natural product large amount energy used dry process much come biomass tree requires investment plant always possible industry widely distributed among many small producers build wood good use natural resource aspects civil structural engineering large scale infrastructure better use wood consider holistic picture ranging scale science cell wall engineering global policies construction people
multiple assessment directed novelty search introduced authors extension novelty search algorithm exploits observation populations optimised phenotypic novelty contain solutions multiple independent conflicting objectives shown application evolutionary trajectory simultaneously directed towards multiple conflicting objectives previous results series simulated maze navigation experiments shown significantly outperform novelty search domains potential phenotypic exploration high paper explore algorithm assessing effect upon diversity performance population phenotypic landscape increases series experiments domains multiple conflicting objectives expanding areas irrelevant space show relative performance gain increases alongside potential exploration conclude potential exploration within domain expands importance directing novelty becomes ever necessary
dynamic systems becoming steadily important mobile distributed computing devices incremental computation natural approach deal ongoing changes explore incremental computation parameterized complexity setting show leads non trivial complexity classifications interestingly incremental versions hard problems become others remain hard moreover simple function problems static complexity every level hierarchy exhibits complete problems intractable problems already static form also show lead interesting algorithms improving upon trivial approach using static algorithm step
paper presents novel multimodal system designed multi party human human interaction analysis design human machine interfaces multiple users challenging simultaneous processing actions reactions consistent proposed system consists large display equipped multiple sensing devices array video cameras depth sensors multiple users positioned front panel freely interact using voice gesture looking displayed content without wearing particular devices motion capture sensors head mounted devices acoustic visual information captured processed jointly using established state art techniques obtain individual speech gaze direction furthermore new framework proposed model multimodal interaction verbal nonverbal communication events dynamics audio signals obtained head poses extracted video images modeled using hybrid dynamical systems show temporal structure characteristics used multimodal interaction level estimation useful feedback help improve multi party communication experience experimental results using synthetic real world datasets group communication presentations show feasibility proposed multimodal system
report synthesis two new artificial scaffolds featuring adequate hydrogen bonding donors molecular recognition base pairs respectively structures various amino acids assessment artificial acid conjugates rna ligands model hcv domain also reported compound displayed highest affinity twice lower control moreover appears interaction favored elsevier ltd rights reserved
recent variants distributed denial service attacks leverage flexibility application layer protocols malicious activities normal traffic patterns concurrently overwhelming target destination large request rate new countermeasures necessary aimed guaranteeing early reliable identification compromised network nodes work introduce formal model aforementioned class attacks devise inference algorithm estimates hidden network converging true solution time progresses notably analysis validated real network traces
africa around per hiv aids related deaths due affects fungal infection recently world health organisation infectious disease society america recommended first line treatment combination amphotericin now essential medicines however even registered use african nation due part relatively high cost manufacture lack generic manufacturers currently manufactured expensive four step manufacturing process report one step continuous flow process involving reaction inexpensive gas using stainless steel tubular laboratory pilot scale silicon reactor devices readily manufacturing process low initial capital expenditure
surgical site infection common complication following surgical procedures study aimed determine risk factors associated patients crohns disease complicated gastrointestinal retrospective review patients underwent surgical resection gastrointestinal patients january january identified prospectively maintained gastrointestinal database demographic information preoperative medication intraoperative findings postoperative outcome data collected univariate multivariate analysis carried assess possible risk factors total patients identified men average age patients years average body mass index bmi rate multivariate analysis preoperative anemia preoperative bacteria present tract preoperative nutrition months predictors notably preoperative percutaneous drainage shown exert protection preoperative anemia bacteria present tract preoperative months significantly increased risk postoperative gastrointestinal complicated preoperative identification risk factors assist risk assessment optimize preoperative preparation perioperative care
long island sound watersheds experiencing significant land use cover change affects environment ecosystems watersheds water pollution carbon emissions loss modeling important approach understanding happened landscape change future moreover prospective modeling provide sustainable efficient decision support land planning environmental management paper modeled new england region experienced increase developed area decrease forest low density development pattern played important role loss forest expansion urban areas key driving forces distance developed areas distance roads social economic drivers light intensity population density addition paper compared evaluated two integrated models logistic regression markov chain model multi layer perception markov chain model models achieved high accuracy prediction model performed slightly better finally land use map predicted using model indicates continued loss forest increase developed area
electrical circuits difficult understand tend inadequate understandings happens level atoms electrons leading difficulty predicting outcomes electrical circuits level wires resistors light paper argue integrating micro macro representations electrical circuit provide students better understanding fundamental concepts electricity introduce spark interactive multi level simulation environment enables learners interact representations electrical circuit levels primary goal design students electrical current resistance potential difference circuit conducted study university students shows ability design improve novice understanding electrical circuits study offers evidence learners able develop better understandings fundamental concepts electricity drawing micro level macro level representations electrical circuit
games constitutes worlds largest sporting event nurses play important poorly discussed role emergency care routine clinical care preventive care athletes many cultures enormous influx article discuss five important considerations preparing nurses provide safe care elite athletes cultural group caring family disaster security infection control principles nursing nature sports types injuries effects climate challenges differ somewhat summer winter nevertheless games provide tremendous opportunity experience nursing highlight nurses play significant role care athletes family
background patients negative myeloproliferative neoplasms mpn polycythemia vera essential thrombocythemia primary myelofibrosis pmf increased risk thrombosis thromboembolism major bleeding due morbidity mortality events antiplatelet anticoagulant agents commonly employed primary secondary prophylaxis hand disease related bleeding complications esophageal common patients mpn analysis performed define frequency events identify risk factors assess antiplatelet anticoagulant therapy cohort patients mpn methods mpn registry study alliance leukemia non interventional prospective study including adult patients mpn according criteria statistical analysis descriptive methods tests significant differences contingency tables used identify odds potential risk factors vascular events results mpn subgroups significantly differed sex distribution age diagnosis blood counts ldh levels positivity spleen size length thromboembolic events occurred around time mpn diagnosis one third events occurred date vein thrombosis frequent post mpn patients chance developing thromboembolic event significantly elevated patients suffered post splenomegaly significant odds major bleeding previous thromboembolic events splenomegaly administration heparin major bleeding episodes significantly less frequent patients compared mpn subgroups conclusions together report real world cohort german mpn patients reveals important data prevalence diagnosis treatment thromboembolic major bleeding complications mpn
present work shows teaching learning experience developed department manufacturing engineering university experience based need generate specific manufacturing engineering terms used study guide students eventually decided make aimed teaching activity addition take part educational innovation project university within first step consisted design pattern taking account kind information necessary include pattern place virtual campus student complete information required finally results obtained different applications activity analyzed evaluated published elsevier ltd
sarcoma associated lymphoma mice difficult distinguish histologically studies multiple cases initially diagnosed allowed define round mixed cell types mac lacked markers immune receptor genes germline configuration two subsets clonal populations lymphocytes first featured malignant lymphocytes large populations normal appearing second appeared composites lymphoma several cases suggestive myeloid lineage plasticity also observed
background virus newly recognized human monitoring impact birth prevalence adverse pregnancy outcomes continue urgent need united states worldwide methods centers disease control prevention activated emergency operations center virus outbreak response january public health leadership recognized joint coordinated effort required activities focused effects infection among pregnant women focused birth defects fetuses infants introduction virus population based birth defects surveillance occurred independently pregnancy surveillance activities results coordination pregnancy surveillance birth defects surveillance implemented virus response represents paradigm shift conclusion coordination surveillance systems provides opportunity capture information prospective retrospective approach relatively modest investment public health infrastructure continue protect pregnant women infants ongoing response virus next emergent threat maternal child health wiley periodicals inc
theory mind tom thought play key role social information processing refers ability individuals represent mental states others intentions beliefs hypothesis put forward existence two tom systems one implicit involves automatic analysis belief states others another automatic involved explicitly reasoning others mental states recently suggested limited evidence automatic tom processing identifying previous high profile paper supporting existence cognitive operation infants adults take broader view literature find contrary conclusions substantial body literature demonstrates adult humans able engage thus automatic analyses others mental states however whether ability best described one two multiple systems tom account remains determined elsevier rights reserved
cutting electrical steel cause edge lead short circuits paper based equivalent electric circuit eddy current path analytical method developed estimate eddy current power loss magnetic cores caused faults wide range flux density frequency important factors skin effect flux density distribution complex relative permeability nonlinear relation often neglected literature highlighted fundamental concepts fault consequences effect faults configuration magnetic cores finite element method verification presented part paper modeling eddy current together experimental results eddy current measurements reported part
misuse large public health problem united states residents rural areas american indian trust represent traditionally populations regard substance use disorder therapy differences number opioid agonist therapy facilities physicians drug addiction treatment act data rural versus urban trust land versus non trust land areas state methodsthe unit analysis code dependent variables number facilities data physicians region per residents aged code region defined code codes independent variables binary measures whether code classified rural versus urban trust land versus non trust land zero negative binomial regressions robust standard errors estimated resultsthe number clinics region per code residents significantly lower rural versus urban areas differ significantly trust land non trust land areas data physicians region per code residents significantly different rural urban trust land versus non trust land areas appears potential state residents rural areas receive similar residents outside areas however difficulties accessing therapy remain highlighting importance expanding health care insurance providing support data physicians
adsorption methane twelve carbon different origin structural energy characteristics studied pressures mpa specific capacities calculated methane adsorption storage systems effectiveness adsorption accumulation analyzed terms structural energy characteristics density thermodynamic parameters methane adsorption differential molar adsorption absolute efficiency adsorption accumulation systems evaluated effects increased density proper shape adsorbent material adsorption accumulation efficiency considered shown selection adsorbent optimal porous structure density adjusted thermodynamic parameters accumulation system
purpose study done develop evidence based incontinence care protocol adaptation process evaluate effects protocol methods protocol developed according guideline adaptation non randomized controlled trial used testing effects new incontinence care protocol total patients bowel incontinence stool type admitted intensive care units recruited study newly developed incontinence care protocol used patients experimental group conventional skin care given patients control group outcome variables incontinence associated dermatitis severity pressure occurrence severity results experimental group significantly less severe lower occurrence pressure ulcers less severity pressure ulcers mann whitney control group conclusion use incontinence care protocol effects preventing pressure ulcers inhibiting worsening pressure ulcers therefore incontinence care protocol expected contribute managing pressure ulcers
studies carbon dioxide emissions level provide scientific basis optimal use energy formulation reduction policies studied variation emissions primary energy consumption influencing factors based data autonomous region calculated according guidelines national greenhouse gas emission process divided five stages according growth rates total amount emissions emission intensity impact factors quantitatively analyzed using mean index method stage various factors including government policies technological progress related role emissions comprehensively analyzed internal relationships among various factors clarified results show contribution rates various impact factors different stage overall economic growth energy consumption intensity main driving factors emissions since implementation birth control policy driving force population growth increase emissions slowly weakened energy consumption intensity affected industrial structure energy consumption intensity primary secondary tertiary industries energy consumption intensity secondary industries proportion secondary industries important factors affecting energy consumption intensity governmental policies technological progress also important factors affected emissions
design mobile electronics power one difficult restrictions overcome current trends indicate continue issue future consumer electronic becoming small portable devices provide users wide range functionality communication music playing battery technology power consumption device limit size weight autonomous lifetime one promising alternative batteries use parasitic energy movement device power paper designed system included rotary arm extending sole ultimately small electrical generator one way mechanism used transmit torque allowed additional spin following initial impact step also preventing due rotary inertia entire generator system designed fit standard running rotary arm
vivo liver perfusion offers potential optimize graft function prior liver transplantation hepatitis virus hcv dependent presence mirna microrna locked nucleic acid oligonucleotide mir inhibits hcv replication aim study assess efficacy delivering inhibit mir function pig model pig livers treated cold storage absorption mir mir target gene determined effect treatment hcv infection cells also assessed improved uptake versus significant mir mir target gene seen vitro data confirmed suppression hcv replication established infection prevented hcv infection pretreatment cells analogous pretreatment transplant setting conclusion delivery potential strategy prevent hcv first large animal study provide proof concept using modify optimize liver transplantation
aim unknown whether food allergies greater impact quality life respiratory allergies study compared health related quality life hrqol children allergic wheat grass methods surveyed children wheat allergies median age five grass allergies median age parents child health questionnaires parents children applied results parents children wheat group recorded significantly lower scores impact childs allergy general behaviour general health perceptions parental impact emotions time family activities parents children grass allergies values however parents grass group recorded lower scores change health item parents children wheat allergies grass group children parents reported similar scores different questions poorer correlation parents children wheat allergy group conclusion hrqol lower children wheat grass allergies according parental reports consistent perceptions hrqol among parents children grass allergy wheat allergy group
accurate fast running stable six group point kinetics model developed applied successfully dynamic simulation operation core high temperature next generation nuclear plant reactor model size time step much several seconds accounts doppler fuel graphite temperature reactivity includes active neutron source zero power reactor efficient robust numerical technique exponential matrix using order accurate function discretization error order delta solves coupled nonlinear six groups point kinetics equations model handles reactivity insertions excess prompt critical rho beta bar time step size model results successfully using solution step insertion external reactivity simulate transient response reactor following external reactivity insertion model coupled nodes thermal hydraulics model reactor also developed work time step error predicting reactor thermal power similar increasing exponentially similar similar increased time step size respectively present model successfully incorporated nuclear reactor analysis code simulate transient operation high temperature reactor electricity generation using closed cycle generation hydrogen using sulfur iodine thermo chemical processes elsevier ltd rights reserved
studies investigated effects exercise training sleep physiology trained athletes investigated changes sleep markers mood state exercise performance trained undergoing short term intensified training carbohydrate nutritional intervention thirteen highly trained male age min participated two day periods intensified training undergoing high moderate con carbohydrate nutritional intervention training sessions sleep measured night via actigraphy mood state questionnaires completed daily performance assessed maximal oxygen uptake percentage sleep time fell intensified training despite increase time bed sleep efficiency decreased intensified training actual sleep time significantly higher con throughout intensified training mood disturbance increased intensified training higher con performance exercise protocol fell significantly intensified training main findings study days intensified training highly trained resulted significant progressive declines sleep quality mood state maximal exercise performance
trans agency workshop blood brain interface sponsored national heart lung blood institute national cancer institute combat care research program department defense conducted june workshop structured four sessions blood sciences therapeutics next generation vitro blood brain barrier models delivery targeting first day workshop focused physiology blood neuro vascular unit blood based molecular markers extracellular vesicles associated brain injury entities employed better evaluate injury states deliver therapeutics second day workshop focused technical advances vitro models manipulations nanoparticle based drug carrier designs goal improving drug delivery central nervous system presentations discussions role brain injury role limiting factor potential drug delivery brain conclusion meeting participants discussed challenges opportunities translational researchers particular participants recommended using translational research stimulate advances diagnostics targeted delivery approaches detection therapy brain injury disease
population genetic structure freshwater organisms depends upon arrangement streams extent connectivity ponds terrestrial dispersal capability assessed population genetic structure patterns gene flow total european pond sampled ponds along river northern greece analysis mitochondrial dna mtdna control region sequences nuclear dna species specific microsatellite loci recorded high level genetic diversity suggested gene flow following recent history colonization pattern advocated overall low level nuclear dna differentiation limited significant sequence divergence among mtdna haplotypes significant level genomic across central ponds high proportions individual genomes downstream upstream ponds belonging genetic cluster defined bayesian analysis male mediated gene flow emphasized role river dispersal rule short distance terrestrial movements work contributes fine scale population structure studies freshwater organisms habitats affected human activities provides information help devise management conservation plans lake national park system
machine design perspective field study faculty mechanical engineering university west regards demand graduates field days main issue higher education czech republic related machine design lack opportunities students machine design acquire practical knowledge experience field problem engineering companies offer work experience individual students try engineering companies motivated enough contribute machine design teaching process providing knowledge experience majority students going change soon universities provide real applications students instead currently enough opportunities students acquire practical knowledge field studies required amount work experience engineering students czech republic one week insufficient comparison german system mandatory part studying university applied sciences necessary provide practical information real applications class compensate lack practical experience concerned matter launched project enhancement teaching process new concept electronic learning materials machine design developed part project learning materials developed academics cooperation local engineering companies provide students academics real design projects learning purposes machine design teaching process complicated due complexity mechanical design process need considered creating learning materials describing mechanical design process design process described also production processes project schedules economic aspects design project technical standards regulations described parts mechanical design process affect important describe context mechanical design process show interconnection electronic form learning materials selected offers many advantages standard printed form main reason selecting electronic form learning materials ability work computer aided engineering models three dimensional models replaced drawing boards every engineering company several years ago thus important include models machine design teaching process thanks technology models standard portable document format possible modify models learning purposes use learning tool models enhanced large amount information regarding design project manufacturing processes materials component functions supplemented technical illustrated project descriptions information learning material converted single file every student access anywhere versatility biggest benefits new electronic learning materials new electronic learning materials used explaining new subject matter show application basis students assignments individual work teamwork sample electronic learning materials produced made available students university west paper intends present learning materials describe form structure content benefits academics students machine design
purpose study determine whether coa reductase inhibition attenuate early pressure overload induced activation extracellular matrix genes left ventricle heart sprague dawley rats randomized treatment groups sham operation vehicle aortic vehicle rats injected normal nacl daily beginning day surgery days surgery hemodynamic measurements made open chest state levels transforming growth factor beta tgf beta mrna measured northern blotting induced similar increase weight days altered treatment expression tgf beta mrna similar fold similar fold similar fold greater respectively compared rats days post operation significantly decreased either dose inhibition coa reductase attenuate pronounced aortic induced increases early expression tgf beta model acute pressure overload rat heart
congenital bleeding disorder characterised recurrent major joints established outcome recurrent joint bleeding however clear multiple factors determine extent severity occurrence sought identify genetic factors related abnormalities range motion cohort children adolescents treated primarily regular prophylaxis using data growth development study examined associations genetic markers scores measured six month intervals seven years first step ordered logistic regression models fit joint separately subset snp markers showing significant effects right left sides least two joints included full model fit using multivariate generalised linear mixed model assuming ordinal response models contained scores obtained visits twenty five markers analysed full model showed either increased decreased risk abnormalities level several genes identified either first second stage analysis associated arthritis variety large studies results support likelihood risk associated genetic factors identification holds promise advancing treatment
effective project coordination management time cost scheduling public funded construction projects receive considerable focus academics politicians construction industry opposing points view study objective therefore investigate process time cost scheduling different project stages relationships critical factors affecting project schedules applied data collection based semi structured interviews questionnaire survey publicly agency employed project managers property managers multiple research approach thus utilized mix two dataset findings demonstrate project complications execution stage associated lack project requirements design project budget initial project stages moreover relationship found presence experienced achievement project success throughout project phases particular vital
water quality issues watersheds greatly attributed rapid urban development stormwater runoff pollution contribution agricultural practices still significant often overlooked objective study assess water quality impacts managing agricultural urban watershed river watershed watershed mixed land uses located county new usa agricultural urban represents typical natural resource conditions water quality problems new usa soil water assessment tool used evaluate potential water quality impacts agricultural urban land use management practices watershed four management scenarios baseline best case worst case developed interviews meetings farmers natural resource conservation professionals represent achievable ideal worst operation conditions urban agricultural watershed specific water quality parameters assessed soil total nitrogen phosphorus losses modeling results demonstrate urban agricultural watersheds worst case significantly exacerbate existing water quality problems till row crops best case necessarily improve water quality agriculture still primary source water pollution attention continuously paid implement agricultural reduce agricultural source pollution watersheds
introduction provide effective form birth control men choose reversible permanent form contraception presently offered permanent option male contraception patients interested reversal temporary birth control option paper determine offered selected couples temporary form contraception circumstances materials methods review conducted determine available reversible contraceptive options risks failure rates risks success rates reversal results reversible contraceptives include based methods women non hormonal anatomic barrier devices agents hormone based therapies women cardiovascular disease hypertension cancers non hormonal contraceptives generally less effective couples due higher failure rates difficulty use lack acceptance reversal low risk procedures reversal performed high degree success particularly short obstructive interval performed years following conclusion considered permanent form sterilization couples select couples unable use forms birth control benefit informed discussion using reversible form contraception
article suggests new method errors evaluation several common mode signals differential difference operational amplifiers based theory autonomous circuit errors main connection circuits described feeding special current autonomous parameter classical equivalent circuit parameter connected node depends level common mode components inputs input differential stages also parameters spread elements paper shows common mode rejection ratio significantly comparison classical amp parametric circuitry methods increase based inherent compensation parasitic considered
paper presents adaptive neural controller achieve precise rotor position tracking nonlinear active magnetic bearing system modeling uncertainties external disturbances proposed single hidden layer feedforward networks used approximate unknown nonlinearities dynamic systems based approximated models neural controller constructed different existing methods hidden node parameters determined using recently proposed neural algorithm named extreme learning machine parameters assigned randomly without adjusting simplifies controller design process using lyapunov theory stable tuning rules derived update output weights proof stability uniformly bounded sense given resulting controller moreover online computation burden existing simplified less parameters adjusted online proposed improve control performance finally simulation results demonstrate proposed achieve better tracking performance comparing controllers including pid controller conventional controller adaptive sliding mode controller also results show much less computation complexity also better tracking performance elsevier rights reserved
investigated preclinical abnormalities revealed transcranial patients idiopathic rapid eye movement sleep behavior disorder compared revealed patients multiple system atrophy parkinsons disease normal controls two patients patients patients normal controls included study participants underwent one night video monitoring sleep parameters analyzed using software visual analysis performed following standardized procedure substantia nigra basal ganglia evaluated resultsa greater proportion patients found substantia nigra compared patients patients normal controls fourteen patients patients basal ganglia whereas basal ganglia less frequent patients normal controls poor sleep efficiency less stage sleep time periodic leg movements found patients whereas patients almost normal sleep patients basal ganglia similar observed represent another possible convert direction present study confirmed prodromal stage detect subclinical changes thus provide useful markers identifying individuals increased risk developing
hereditary angioedema hae rare debilitating autosomal dominant disorder caused mutations inhibitor gene results increased bradykinin levels usually angioedema occurs commonly associated urticaria report disorder young male presented recurrent painful swelling involving various parts body abdominal without signs urticaria patient diagnosed hae type based history poor response treatment angioedema low inh antigenic levels
purpose triglycerides considered emerging risk factor cardiovascular mortality recent evidence relating depression metabolic syndrome mets implicated triglyceride levels thus investigated self reported depression severity mets related biological measures cvd risk estimates mets patients methods patients fulfilling international diabetes federation criteria mets nationwide sampled treatment cohort mets familial risk manifest governmental health care system participants laboratory non laboratory measures included recent european score system cvd risk estimates used outcome variables results following correlation matrix entered variables principal component analysis pca explained variance followed hierarchical regression structural equation modeling sem pca suggested one factor solution latent variable showed highest loadings score risk estimates triglycerides depression severity pulse pressure comprehensive sem adjusted explained variance overall cvd risk related depression pulse pressure triglycerides fasting glucose conclusion findings mets sample suggest triglycerides depression severity key variables among mets biomarkers cross fatal total score risk estimates mets
objectiveto explore prevalence clinical profile males females develop antidepressant treatment emergent mania original sample patients identified cases controls met stringent criteria specifically examined combinations clinical factors best classified males females cases five individuals classified events occurred antidepressant monotherapy regression analyses demonstrated presence alcohol substance use disorder odds ratio history one suicide attempts higher number depressive episodes per year illness correctly classified males contrast females correctly classified basis positive history thyroid disorder positive family history depressive onset polarity stringent definitions status reduce probability inclusion false positive cases false negative controls identified first time risk profiles development differ significantly according gender
mammalian implicated cell differentiation pathogenesis inflammatory diseases available structural information indicated constitute single polypeptide chain enzymes consisting small terminal beta domain larger terminal subunit catalytic non heme iron structural similarity domains terminal beta domain comprises amino acids implicated membrane binding activity regulation explore functional relevance detail develop comprehensive hypothesis biological role structural subunit performed gene technical various mammalian isoforms various species human mouse quantified catalytic activity membrane binding properties truncated recombinant enzyme species found domain essential catalytic activity hardly impact reaction specificity truncated enzyme species exhibit impaired membrane binding properties altered reaction kinetics taken together data suggests regulatory importance terminal beta domain mammalian isoforms elsevier inc rights reserved
background season vitamin indirect direct correlates ultraviolet radiation associated pregnancy outcomes producing vitamin positive effects cardiovascular immune health support role directly pregnancy objectives investigate effects exposure pregnancy specifically fetal growth preterm birth hypertensive complications methods conducted systematic review medline embase global health public health scopus google scholar identify citations included review review registered narrative synthesis presented following prisma guidance results studies observational assessed high risk bias higher first trimester associated improved fetal growth increased hypertension pregnancy interpretation limited study design quality meta analysis variety outcomes methods discussion low number studies risk bias limit validity conclusions environmental health methodological issues discussed consideration given design analytical improvements address reproductive environmental health question conclusions evidence benefits pregnancy hypertension fetal growth limited methodological approaches utilized future epidemiological efforts focus improving methods modeling linking widely available environmental data reproductive health outcomes
purpose analyze efficacy edema resistant various immunomodulatory drugs methods patients received every weeks central thickness assessed optical coherence tomography oct results five patients eyes pretreated systemic least one immunosuppressive drug least one biologic drug edema included study months response reduction observed eyes patients follow complete resolution achieved eyes patients improvement observed eyes patients stabilization eyes patients tolerated severe side effects occurred conclusions treatment considered chronic edema even previous immunomodulatory therapy failed
since discovery years ago small rnas shown play critical role myriad biological processes greater availability high throughput sequencing understanding small rnas regulatory molecules particular sequencing technologies crucial understanding role small rnas reproductive tissues millions individual sequences generated context high throughput sequencing provides level resolution procedures like northern blotting able achieve describe protocol preparation small rna libraries sequencing using illumina technology
researchers use race now conduct health care studies definition question belief race social construct without biological though widely shared across disciplines social science traditional science yet interdisciplinary approach two social construct genetics dilemma race mutually exclusive use traditional science provide rigorous framework use social science approach factors used adjust design studies needed basis one approach first observe health care outcomes categorize outcomes thus removing genetic differences racial design study outcomes determine pattern racial categories needed apply dynamic notions race bias without prejudice use improve outcomes reduce racial disparities another approach nearly identical considers race analyzing outcomes determine biological differences significant enough identify classifications humans look genetic patterns outcomes classify patterns attempt link patterns race
two circuit solutions fully differential current mode band pass filter presented paper main feature circuits quality factor electronically adjusted independently natural frequency omega via single active element namely digitally adjustable current amplifier control directly indirectly proportional current gain depending circuit structure used behavior proposed structures verified spice simulations
paper presents neural network controller reducing roll motion using active classical pid controllers fail control roll dynamic parameters ship change innovative approach used overcome disadvantage wherein three different conditions ship stability chosen pid controller tuned separately cases training data derived pid controllers design neural network controller controller thereafter fine tuned considering various input combinations training different number hidden neurons design best neural network controller reducing roll controller also intended avoid ship worst stability conditions
paper considers financial costs rapid national transition electric vehicles evs comparison baseline scenario characterised continuing use internal combustion engine vehicles australian car responsible national greenhouse emissions used case study explore potential range costs associated rapid climate mitigation via transport sector transition assumed occur rapidly analysis urban areas extensive charging infrastructure assumed made available including rapid charging facilities due uncertainty input variables two boundary scenarios constructed high cost scenario rapid shift evs found cost approximately continuing use assessed period however low cost scenario costs evs especially batteries fall rapidly maintenance costs lower end projections liquid fuel costs higher end projections rapid transition evs found cost approximately use ice vehicles suggests rapid transition towards technologies urban car travel offer cost effective second best climate change mitigation strategy comprehensive transport sector transformation including changes transport land use policy designed facilitate mode shift reduce costs transition elsevier ltd rights reserved
nicotine replacement therapy effective intervention smoking cessation adherence tends low article presents results pilot evaluation brief smoking cessation treatment improve adherence nicotine patch among latino smokers living hiv aids forty smokers randomized receive either standard counseling session week treatment nicotine patch similar intervention added min module counseling focused improving adherence nicotine patch smoking outcomes breath carbon monoxide monitoring verified day point prevalence continuous abstinence evaluated month follow patch usage follow period also assessed intention treat analyses indicated abstinence rates times higher adherence condition compared standard condition day point prevalence abstinence continuous abstinence nicotine patch compliance week period also higher adherence condition standard condition although small pilot conducted estimate effect sizes powered detect group differences results promising suggest adding min module focused nicotine patch adherence standard protocol increase abstinence rates given smoking cessation treatment specifically tailored either hiv positive smokers latino smokers future research examine whether promising approach improving nicotine patch adherence general population smokers
aim present study determine effects intercellular adhesion molecule expressing mesenchymal stem cells mscs mice autoimmune thyroiditis following induction experimental autoimmune thyroiditis eat model mice randomly divided following groups normal control experimental groups subject eat induction including eat model iii primary msc msc msc msc administered relevant cells mscs administered via vein blood sample harvested angular vein animal days post treatment elisa used determine serum total triiodothyronine total thyroxine thyroid stimulating hormone tsh anti thyroid peroxidase anti thyroid anti antibodies hematoxylin eosin staining performed evaluate injury thyroid gland determining size follicle inflammatory infiltration substance retention epithelial injury reverse transcription quantitative polymerase chain reaction performed determine mrna expression interleukin interferon western blot analysis performed determine expression mitogen activated protein kinase extracellular signal regulated kinase erk observe cellular migration vivo mice divided following groups subject eat induction labeled primary msc labeled msc iii labeled msc labeled msc administered relevant cells via vein mscs able ameliorate expression tsh vivo attenuate thyroid follicle injury decrease index mice also able ameliorate mrna expression modulation erk signaling pathways mouse spleen furthermore overexpression able modulate mscs thyroid gland lung findings suggest msc affect differentiation proliferation migration modulating erk signaling pathways modulate effects mscs affecting migration mscs vivo
aim determine whether serum drug concentrations obtained neonates umbilical cord used prognostic factor admission ward occurrence withdrawal symptoms retrospective observational cohort study carried among pregnant women using psychotropic drugs baby binary logistic regression used multivariate analysis neonates included admitted ward withdrawal among women therapeutic concentrations psychotropic medication neonates withdrawal symptoms comparing neonates therapeutic versus undetectable drug concentrations odds ratio confidence interval found admission ward odds ratio confidence interval occurrence withdrawal symptoms therapeutic concentrations psychotropic drugs neonates umbilical cord blood correspond higher odds admission ward occurrence withdrawal symptoms compared neonates undetectable drug concentrations measurement drug concentrations contribute toward general clinical assessment physician predict necessity admission ward risk withdrawal symptoms
used substitute phthalate based like phthalate discussed regulated due reproductive toxicity developed fast method quantify side chain oxidized human urine namely sample preparation kept simple enzymatic two column assembly line sample clean metabolites identified authentic standards quantified via isotope dilution limit quantification accuracy relative recovery precision relative standard deviation highly acceptable pilot study volunteers aged median female male known exposed detect limit quantification samples median maximum metabolites investigated detected lower rate lower concentration levels maximum maximum maximum target analytes regarded promising specific urinary biomarkers exposure method provide basis quantitatively investigating human metabolism performing exposure risk assessments general population working environment elsevier rights reserved
aberrant cell immune responses appear central development systemic lupus erythematosus sle previously reported alpha subunit regulates cell immune responses promoting autoimmunity address whether contributes pathogenesis sle mrna expression studied using real time pcr pbmcs cells sle patients age sex matched healthy controls results showed mrna expression decreased pbmcs cells sle patients compared healthy individuals correlation analyses showed expression cells sle patients associated disease severity per sle disease activity index presence lupus expression cytokines keeping clinical results helper cell subsets represented knockout mice addition expression sle cells negatively correlated expression bcl anti apoptotic gene positively correlated expression bax pro apoptotic gene data suggest reduced levels cells promote enhanced prolonged cell activation contributing clinical manifestations sle
bioactive food chemicals substances present food capable interacting living cells causing changes physiological functions acid plant hormone involved plant immune response one bioactive food chemical aspirin commercially available play beneficial roles cardiovascular health colon cancer also cause urticaria angioedema asthma gastrointestinal symptoms sensitive individuals dietary exert similar beneficial effects induce similar symptoms individuals food related sensitivity relation gastrointestinal symptoms documented besides self reported questionnaires knowledge low doses aspirin equivalent high dietary intake cause gastrointestinal injury direct evidence suggests benefits reducing dietary reported asthmatic individuals although sensitivity relation gut symptoms susceptible individuals accepted clinicians detection disease remains challenge complicated nature dietary challenges risk oral aspirin tests patients severe hypersensitivity reactions given non ige mediated nature disease vitro assays like activation failed produce reliable results however given simplicity assay studies need formulated establish reliability formulation proper dietary strategies symptom control also impossible given controversial scant nature data content food issue needs resolved formulate proper dietary strategies effective symptom control
feedback control perturbations plane flow considered due non normal nature dynamics flow small perturbations experience transient growth zero stable regime high enough amplitudes path zero blocked exciting nonlinear effects process leads turbulence navier stokes equations describe perturbations transformed finite dimensional state space representation method vortex injection boundaries devised actuation mode latter implemented peak peak control scheme appropriate set allow optimised trade transient energy reduction control effort control scheme first applied equations consequently integrated numerical simulations full nonlinear three dimensional navier stokes equations significant reduction transient energy growth achieved suppression transition turbulence full numerical simulations demonstrated perturbations finite initial amplitudes
extant research connecting borderline personality disorder bpd sexuality sparse current study aimed expand limited body research borderline personality traits human sexuality light personality features contribute specifically sexual sensation seeking sexual sexual risk taking behaviours undergraduate students completed online questionnaire containing scales assessing bpd symptoms affective instability identity disturbance negative relationships self harm sexual sensation seeking sexual sexual risk taking multiple linear regression analyses conducted revealed significant gender symptom interaction predictors results indicate links specific bpd symptoms specific sexuality variables total sexual compulsive sexual control behaviours positively predicted four bpd symptoms whereas compulsive sexual violence predicted symptoms except identity disturbance sexual sensation seeking positively predicted negative relationships self harm sexual risk taking significantly predicted bpd symptoms findings improve understanding individuals borderline personality traits experience romantic sexual relationships inform future development therapeutic interventions
article describe history current state medicine japan propose measures considered based view future prospects japan japanese society established first department internal medicine japan established university japan shown prominent unique development members march comprised medical doctors including internal medicine specialists general psychiatrists pediatricians dermatologists others non physician members include psychology nursing staff specialists japanese society internal medicine founded another major society physicians mainly composed first joint congress five major societies field held included japanese society medicine obstetrics gynecology pediatric medicine dental medicine internal medicine several subdivided societies related medical fields also established cardiovascular digestive dermatological medicine eating disorders pain stress science behavioral medicine psycho oncology participate international activities including publishing medicine establishment society relationship germany college japan adopted variety professional including analysis therapy cognitive behavioral therapy mutual promoted japanese union associations psycho medical therapy although japan functioning high level remain areas improved among medical schools japan just eight university hospitals independent department dental schools three dental university hospitals department accumulation evidence regarding mind body relationship clinical basic science based latest advanced technology necessary medicine community needs make even greater contribution meeting needs modern society possibilities future development japan widely discussed
commodity operating system kernels vulnerable wide range attacks due large code base broad attack surface mitigation mechanisms code circle plus code integrity protection raised bar kernel security turn attack mechanisms also become increasingly advanced evolved simple injection malicious code sophisticated code reuse attacks return oriented programming study authors describe exception oriented programming novel code reuse method construct kernel unlike previous reuse limited part existing code able reuse instruction existing code chain instructions order generate malicious programmes result provide attackers powerful capabilities less complexity building kernel
background collection plaque samples paper points time consuming accident sensitive however collection saliva simple contains pathogens surfaces aim study investigate whether sampling strategy sample test leads results comparable standard sampling method multiple site test pocket control methods patients periodontitis plaque sampled pocket using paper points gaining saliva saline analysis performed using commercially available polymerase chain reaction test periodontal pathogens results detection frequency higher difference test control detection frequency species higher differences significant conclusions significant difference detection frequency key pathogen key pathogens show statistically higher detection frequencies
memory experience defined evaluations familiarity novelty stimulus sought generate laboratory pairing drm recognition task generates erroneous familiarity critical words monitoring task participants familiar words fact novel tested participants experiment varied participant awareness stimulus novelty erroneous familiarity strength found reports frequent high novelty critical words similar low novelty critical words yielding baseline levels report frequency similar significant variation report frequency according familiarity strength accounts experimentally generated experience suggest aspects naturalistic experience captured analogue analogue also limited focus prone influence demand characteristics discuss theoretical methodological considerations relevant development procedure propose novelty important component naturalistic experimental analogues
composites made sources become important alternative materials designing manufacturing engineering industrial products natural fiber composites become superior materials compared conventional fiber composites due easy manufacturing process high fiber content reduction base content lightweight environmental increasing concern look sustainable alternative materials replace conventional materials used now natural fibers constitute good alternative reinforcement material since readily available fibrous form extracted low costs present study environment friendly green composites prepared mechanical properties composites evaluated results indicated significant improvement tensile flexural impact properties hybrid composites effect hybridization reduces environmental effects internal structure broken surface fibers failure morphology analyzed using scanning electron microscopy analysis
two separate geotextile bag systems evaluated means capturing bio solids effluent stream aquaculture systems ras geotextile bag system used high molecular weight cationic polyacrylamide polymer aid two systems operated freshwater water conditions complete analysis including water quality sludge analysis conducted north state university fish large scale freshwater ras demonstration facility evaluation water quality performance similar geotextile bag system also conducted marine aquaculture research center near north usa conditions results indicated performance systems similar cod removal greater respectively systems analysis sludge collected freshwater system days inactive mode showed moisture content dry matter indicating system effective bio solids nutrient removal efficiency system specific based geotextile bag size flow rate geotextile bag systems using aids efficient means capturing waste solids ras effluents optimized geotextile bag system designs depend flow rate feed rate solids time fate treated effluent evaluation aid predicting expected performance determining appropriate size geotextile bag system type treatment required downstream geotextile bag system used solids capture ras wastewater treatment system depend intended fate treated effluent elsevier rights reserved
humans connection sleep mood long recognized although direct molecular evidence lacking identified two rare variants circadian clock gene humans familial advanced sleep phase accompanied higher beck depression inventory seasonality scores transgenic mice showed altered circadian period constant light exhibited phase shifts sleep wake cycle short light period photoperiod paradigm molecular characterization revealed rare variants failed stabilize proteins play critical roles circadian timing although mice showed mild depression like phenotype knockout mice demonstrated consistent depression like behavior particularly studied short photoperiod supporting possible role mood regulation findings suggest sleep mood regulation fine tuning processes adapt seasonal changes
current sources topology made operational amplifier often used sensors requires constant current polarization measuring actuators driving systems theoretical determination overall performances circuits generally known paper presents practical method real output impedance determining current sources based performing two simple measurements results according measurements practical circuit using circuit frequency cut khz using one circuit cut frequency
complete model generator developed order optimise technology application solar thermal generation electricity steady state current densities predicted model shown agree published experimental data two separate genetic algorithm carried power density efficiency electrode temperatures work functions external circuit resistance electrode separation varied result two configurations separately exhibiting maximum power density maximum efficiency parameter ranges applicable solar thermal power examination optimum simulation parameters indicated future developments lowering collector work functions increasing service temperature decreasing electrode positively impact device performance elsevier ltd rights reserved
objectives opportunities skin care product certainly many opportunities many technologies involved work assumed role identifying opportunities develop comprehensive classification system used tool support decision making different professional contexts methods initially employed delphi method identify discuss opportunities skin care product finally used classification system obtained previous phase label patent applications therefore testing suitability utility system results end process achieved category classification system opportunities skin care products also illustrated system used conclusion resultant classification system offers normalized terminology cosmetic scientists interested dealing incremental radical innovations skin care products
objective investigate feasibility safety skin skin care birth moderately preterm infants design prospective cohort study setting study conducted three study sites norway participants ninety preterm infants born gestational ages weeks days weeks days methods comparison groups preterm infants received skin skin care conventional treatment birth results median gestational age birth weight similar two groups weeks days versus weeks days versus differences first body temperature blood glucose level groups conclusion early skin skin contact delivery room moderately preterm infants feasible safe
developmental cell biology crucial evaluate dynamic profiles metabolites emerging model system using whose genome sequence strains available now ready metabolomics investigation study applied matrix assisted laser desorption ionization maldi mass spectrometry imaging analysis identify visualize molecular markers detected tissue specific peaks visualized distribution tissues distinguished tissues specific peaks identified first time molecular via tandem mass analysis artery eye heme heart muscle dopamine nerves first maldi study small hard distinguish dissect various organs furthermore now data profile organ results suggest maldi potentially powerful tool examining dynamics metabolomics conformational changes due metabolic changes
purpose autosomal dominant hyper ige syndrome rare complicated primary immunodeficiency disease pid signal transducer activator transcription gene mutation found cause distribution patients deficiency chinese population clear herein retrospectively report patients deficiency demonstrate clinical immunological genetic features methods patients clinical data collected medical records routine laboratory testing results included lymphocyte subset analysis immunoglobulin quantification mutations investigated sequencing genomic dna results among patients pid clinically diagnosed among confirmed mutant ratio male female patients patients scores points mean ages onset diagnosis years respectively three patients died mean age years eczema recurrent skin infection respiratory tract infection common clinical symptoms present patients study six patients suffered complication vaccination symptoms characteristic facial features patients retention primary teeth patients abnormal bone fractures patients eleven types mutations identified patients including novel mutation conclusions retrospectively report largest chinese cohort patients mutation unique features compared existing literature reports include later age diagnosis significantly higher rate complications lower rate chronic media
purpose review ganglion block used clinicians treatment variety headache disorders facial pain syndromes facial sensory autonomic fibers travel provided scientific rationale symptoms associated head neck syndromes yet despite elucidation pathogenic target optimal method block pain producing properties determined clinicians developed various invasive non invasive techniques shown variable rates success examined available studies ganglion blockade efficacy treatment cluster headaches trigeminal autonomic recent findings studies demonstrated blockade provide pain relief patients cluster headaches trigeminal autonomic patients conditions showed varying levels duration pain relief blockade efficacy blockade related different techniques targeting choice therapeutic agents summary based current studies blockade safe effective treatment chronic headaches cluster headaches trigeminal autonomic future studies warranted define optimal image guided technique choice pharmacologic agents blockade effective treatment chronic headaches related activation ganglion
background key enzyme nitrogen assimilation synthesis ammonium glutamate plants two types different compartments one major form plant roots directly converts ammonium taken plant roots results gene cdna non chinese cultivar isolated pcr real time polymerase chain reaction race rapid amplification cdna ends techniques classified sequence alignment motif search named subcellular analysis showed distributed cytoplasm cells expressed parts mainly roots verified northern blotting analysis additionally expression influenced source concentration conclusion results suggest novel member family plants significantly related assimilation non chinese demonstrating gene plays important role plant growth development society chemical industry
objective define increased mrna expression member permeability increasing protein family cells non obese diabetic mice animal model syndrome materials methods cells prepared female mice without diabetes control mice total rna prepared cells embryonic cdna mouse panel kit used expression determined cdna microarray analysis pcr real time pcr northern blotting situ hybridization results expression mrna high cells diabetic non diabetic mice weeks age cells mice low expression mrna age weeks relatively high expression stages conclusions mrna upregulated cells mice expression related onset diabetes findings suggest high expression levels predict disease traits onset autoimmunity
disasters present unique challenges teams providing medical assistance populations impacted event review focused characteristics medical teams disaster characteristics developed review methods followed inductive thematic analysis selected articles used identify recurrent themes total articles reviewed eight databases yielding articles four recurrent theme groups identified adaptability flexibility creativity innovation experience training leadership command structure study highlighted key characteristics identified responders effective team functioning interdependence characteristics also identified paucity literature subject results study help guide future research training development medical teams disaster
background symbiotic relationships insects bacteria found across almost insect orders including however still many remaining questions associations including factors drive host associated bacterial composition better understand evolutionary significance association nature studies addressing diversity hosts across locations evolutionary history necessary genus distributed across old world exhibit diets habits using next generation sequencing ngs bioinformatics tools study explores microbial community species distributed across old world compares microbiota samples related hosts across different locations context phylogenetic history results predominant bacteria across samples likely many new strains followed multiple strains lactobacillus others recovered exclusive strains specific idea host bacteria bacterial group correlation results partial tests found host phylogeny influence overall bacterial community geographic location effect conclusions work revealing important aspects biology hosts structuring diversity abundance host associated bacterial communities including role host phylogeny shared evolutionary history
platelet activation response stimulation protease activated receptor receptor differs race one factor contributes difference expression level transfer protein regulator platelet function conducted expression quantitative trait locus analysis identifies single nucleotide polymorphisms snps linked expression level platelet genes analysis revealed snps associated expression level genome wide significance using annotation encode public data one snps functional testing allelic frequency concordance differential expression reporter gene assays confirmed single nucleotide change caused altered transcriptional potency surrounding genomic locus shift assays luciferase assays overexpression studies indicated role transcription factor summary integrated multi data identify along previously described relationship function allows characterise genotype phenotype relationship mechanism gene expression
discovery expansion repeat within noncoding region gene causes amyotrophic lateral sclerosis frontotemporal dementia raised questions protein function potential disease relevance major predicted structural feature protein differentially expressed normal neoplastic cells domain domains best characterized regulation specific proposed also act regulation target recent genetic cell biological studies furthermore indicate protein functions part larger complex also contains chromosome region repeat containing protein proteins important role supported defects morphology mtor complex signaling arising diverse model systems collectively new findings define containing protein complex lysosomal site action central function provide foundation elucidation direct physiological targets elucidation mechanisms whereby regulates function help determine reductions expression levels accompany repeat expansions contribute disease pathology
greater strength thermal conductivity component parts portable electronic devices increasingly required due increased degree integration shock factor result mobility regard necessary conduct research improve physical properties using glass filters study focused identification regions glass crystals crystals phase coexist observed react system glass create crystals course sintering also reacted phase generated however average particle diameter relatively large created following addition less result evaluation strength thermal conductivity found physical properties rapidly fell phase generated
limited research examined social context surrounding stigma discrimination hiv outcomes among people living hiv surveyed brazil examined relationship stigma discrimination hiv outcomes utilising multivariable logistic regression hiv stigma discrimination inversely associated age aor stigma aor discrimination income aor stigma aor discrimination stigma inversely associated education aor history sex work aor positively associated children aor discrimination inversely associated history drug use aor stigma discrimination found inversely associated overall health aor stigma aor discrimination discrimination associated sexually transmitted infection since hiv diagnosis aor findings suggest future interventions address multiple social inequalities faced reduce hiv stigma discrimination improve health hiv outcomes
large amount variables need taken account studying effects violent content digital games one difficulty current study participants played modified first person one four different conditions either high low difficulty high low violent game content assessed number number deaths game performance neither difficulty displayed violence effect arousal play post game aggressive cognitions aggressive behavior thus study previous research indicating violence games substantially influence human behavior experience game characteristics deserve attention game effects studies addition findings showed challenge manipulated game difficulty main importance post game emotions number deaths predicted positive affect low difficulty condition number positive predictor positive affect negative predictor negative affect elsevier ltd rights reserved
increasing use databases abundant opportunity investigate new techniques requirements emerging applications major challenge needs recover crucial information lost due malicious attacks database represents asset needs protection paper elucidate scheme robust multiple resolve twin issues ownership recovery information case data loss resolve ownership conflicts prepared embedded selected positions database granular information user specified crucial attributes manner perturbed lost data regenerated conveniently later theoretical analysis proves probability identifying target locations false hit rate false miss rate negligible experimentally verified proposed technique robust enough extract accurately even addition alteration deletion experiments information recovery reveal successful regeneration lost data improves increase number candidate attributes embedding elsevier ltd rights reserved
online visual analytical system based java web air quality data shanghai designed implemented quantitatively analyze qualitatively visualize air quality data analyzing architecture java web firstly designed overall scheme system architecture put forward software hardware environment also determined main function modules system visual system ultimately established layout method combined computer programming languages based java programming environment moreover spring frameworks integrated system purpose easy maintenance expansion provide mapping service spatial analysis functions selected server gis server also used oracle database file store spatial data non spatial data order ensure data security addition response data web server implement rapid visualization experimental successes indicate system quickly respond users requests efficiently return accurate processing results
major issue dairy early automated detection offers animal welfare benefits together potentially high commercial savings farmers current advancements automated detection achieved sensitive measure classifying early novel proxy using dimensional depth video data analyse animals gait asymmetry introduced dynamic proxy derived height variations hip joint walking video capture setup completely facilitates automated process animals recorded using overhead depth camera walk freely single file session depth image body used automatically track key regions spine height movements calculated regions form locomotion signals study analysed using hilbert transform results using locomotion scoring system dairy threshold identified boundary important represents earliest point time considered early detection improve intervention outcome thereby losses reducing animal suffering using linear support vector machine svm binary classification model threshold achieved accuracy sensitivity detecting specificity detecting non published elsevier ltd rights reserved
paper show successful integration measurement code quality software development process besides choosing suitable tool code analysis metrics proper threshold values concepts removal deficiencies important requirements code quality several cycles development process necessary achieve long term effective integration code quality development process integration static analysis program code achieved plan check act cycle didactic methods software development course university
sleep problems circadian rhythms disturbances common many psychiatric disorders problem cases insomnia paper main findings sleep disturbances features therapy disturbances biological clock genes melatonin pituitary adrenal axis body temperature reviewed relation schizophrenia mood anxiety disorders
study evaluated effectiveness clustered forward procedure teach year old male autism follow written incorporates elements forward total task teaching small number steps units using introducing new units sequentially prompting steps results indicated effective teaching participant follow written results maintained therapist support weeks maintained therapist support removed
physical training essential every athlete related movement explosive force movement speed also related power training high physical training intensity bound lead occurrence various sports injuries affect progress training even physical mental health athletes based article start problems physical training athletes base put forward feasible countermeasures order provide readers reference
face recognition applications widely used different fields like security computer vision recognition process done real time take fast decisions principle component analysis pca considered feature extraction technique widely used facial recognition applications images new face space pca reduce dimensionality image however pca consumes lot processing time due high intensive computation nature hence paper proposes two different parallel architectures accelerate training testing phases pca algorithm exploiting benefits distributed memory architecture experimental results show proposed architectures achieve linear speed system scalability different data sizes facial recognition technology database
secondary osteoporosis frequent complication rheumatoid arthritis result imbalance mechanisms bone metabolism effects serial low dose exposure therapeutic applications weeks serum levels cytokines receptor activator kappa ligand rankl tumor necrosis factor alpha tnf alpha also rankl ratio investigated patients age matched control patients osteoarthritis cytokine measurements performed baseline completion anti antibodies measured patients parallel medication groups limited non steroidal anti inflammatory drugs low dose patients needed patients showed significant decrease tnf alpha levels groups showed significantly decreased levels rankl patients presented significant increase decrease rankl ratio levels results reduction increase cytokines represents molecular basis inhibiting activity secondary osteoporosis explains part effect physical therapy modality key inflammatory disease although reduced levels observed therapy although potentially contribute effect case rather uncertain reduction minor magnitude
chronic fungal infection epidermis subcutaneous tissue common agent brazil advanced cases found many difficulties treatment therefore report case extensive severe failure first choice treatments good response
basic psychological needs competence relatedness autonomy believed facilitate peoples integrative tendencies process psychological conflicts develop coherent sense self present study therefore used event related potentials examine relation need amplitude conflict negativity neurophysiological measure conflict personal decision making participants completed decision making task made series forced choices according personal preferences three types decision making situations created basis participants unique preference ratings obtained prior erp recording low conflict situations choosing attractive option high conflict approach approach situations choosing two similarly attractive options high conflict avoidance avoidance situations choosing two similarly options expected amplitudes larger high relative low conflict situations source localization analyses suggested anterior cingulate cortex generating structure importantly people reporting higher need exhibited larger amplitudes avoidance avoidance situations relative low conflict situations lesser extent also exhibited larger amplitudes approach approach situations relative low conflict situations contrast people reporting lower need exhibited amplitudes poorly discriminated three decision situations results suggest need promote self coherent functioning increasing peoples processing events challenge abilities make efficient self congruent choices
instability premature charge reversal become major limitations charge reversal delivery systems address problem graft poly poly ethylene glycol peg bond designed synthesized facile reaction subsequent base reaction peg functionalized poly acid mpa assemble aqueous solution give peg charge reversal sizes low interestingly mpa peg arbitrarily switch surface charges negative positive status response fluctuation via reversible amino groups desired stability assembly either long term storage physiological conditions doxorubicin loaded mpa peg high drug loading content efficiency result electrostatic attraction vitro release studies revealed less released within environment mimicking physiological condition whereas released weak acid condition resembling microenvironment vitro cytotoxicity study suggested mpa peg possessed excellent biocompatibility loaded mpa peg showed significant cytotoxicity half maximal inhibitory concentration study provides facile effective approach preparation novel charge reversal charges excellent biocompatibility highly promising used safe efficient intracellular drug delivery wiley periodicals inc sci part
background families children affected atopic dermatitis often report fear anxiety regarding treatment topical corticosteroids lead reduced compliance objective study measure standardized questionnaire fear families pediatric patients identify items associated fear methods families pediatric patients enrolled italian centers pediatric dermatology enrolled parents invited fill questionnaire including questions sociodemographic clinical characteristics sets questions corticosteroid general fear specific behaviours regarding determinants level general fear investigated multivariable analysis results total outpatients enrolled parents high instruction level eighty one percent reported certain amount fear multivariable analysis fear associated following items treatment advantages overweight disadvantages dangerous independently specific side effect moreover fear associated fear applying much cream conclusion widespread among italian families children fear associated fear applying much cream thus increasing risk poor compliance treatment failure therapeutic education families use implemented
unified protocol treatment emotional disorders cognitive behavioral intervention designed treat range anxiety depressive related disorders thus far treatment modules studied delivered presented standard sequence presentation modules given patients presentation providing modules varied order irrelevant modules first necessary establish module leads change skill designed promote changes occur absence modules using multiple baseline design accordance single case reporting guidelines behavioral interventions eight patients heterogeneous emotional disorders randomly assigned week baseline assessment phase followed four sessions one four modules emotional awareness cognitive flexibility emotional behaviors results provide preliminary support notion module study leads change associated skill absence modules five eight patients demonstrated reliable change module specific skill addition exploratory analyses suggest emotion awareness training cognitive flexibility modules appeared exhibit change specific associated skills emotional behaviors demonstrated somewhat broad based change across skills
protein based therapeutics started dominate pharmaceutical landscape primarily due high efficacy demonstrated complex diseases despite significant success issues regards safety efficacy quality point considerable debate concern among various stakeholders correlation profile safety efficacy drug particular significant attention researchers worldwide emphasis presently given develop understanding various process parameters molecular biology considerations contribute heterogeneity paper aims review major developments occurred area last decade impact various process parameters expression methods obtaining pre determined levels profiles protein therapeutic developments area real time monitoring control discussed american institute chemical engineers
resistance distance two vertices connected graph defined effective resistance electrical network constructed graph replacing edge unit resistor let circle times times degrees join product composition direct product strong product rooted product two graphs respectively paper formulae resistance distances composite graphs given terms parameters parent graphs properties established explicit formulae obtained resistance distances classes graphs including graphs mesh graphs generalized double graphs
automated identification markers medical imaging one issues proposed recent years many tasks wide application digital image analysis universal algorithm introduce low computational cost system based transform determine markers watershed segmentation purposes nearly circular structures grey scale images red blood cells images obtained optical light microscopy blood search markers performed based ability detect shape parameters characterise behaviour circular structures circular structure edge determined previously order apply direct projections filtered utilising matched filter image peaks close circular structures centres obtained means reverse threshold calculated applied order identify markers reached precision comparable results within state art measure
article presents vision based formation flight control aerial robots special focus failure conditions visual communication proposing combining two strategies new solution presented formation control vision based formation flight state variables leader estimated using image processing kalman filter follower position respect leader based results estimation case visual communication failure error occur estimation variables increase decreased image quality first proposed strategy failure emergence position follower aerial robot obtained combining kalman filters estimated velocity vector velocity vector failure weighting coefficient velocity vector obtained fuzzy logic based image quality second strategy reduce possibility collision members geometry formation pattern expanded function image quality distance members expansion coefficient also extracted fuzzy inference method desired distance members increased function expansion coefficient two strategies combined used failure periods finally simulation studies presented conducted based system nonlinear equations model degrees freedom member proposed visual noise model obtained results reveal proper capability proposed hybrid strategy terms controlling formation flight failure conditions
objective evaluate respiratory function post operative early period patients undergoing bariatric surgery using technique methods prospective observational study conducted university health application research centre turkey june december comprised patients planned bariatric general participants visited hours operation record accompanying diseases demographic data operations respiratory function test maximum pressure pressure arterial blood gas assessment tests done recorded one hour operation scores mentioned tests repeated recorded spss used statistical analysis results participants women men overall median age years inter quartile range years mean median values forced volume second forced vital capacity maximum pressure maximum pressure ratio partial pressure oxygen arterial blood fraction inspired oxygen interquartile range interquartile range respectively compared interquartile range interquartile range also participants given given end test odds ratio confidence interval pre operative ratio partial pressure oxygen arterial blood fraction inspired oxygen odds ratio confidence interval found correlate significantly conclusion impairment respiratory function found early post operative period
many pathogens present human environment immunocompromised patients cause extremely severe opportunistic infections patients suffering immunological disorders rarely treated facial departments special cases require direct clinical approach fungal infections facial area occur often opposed infections bacterial flora frequently found special conditions requirements needed present occurrence fungal infections found many treated locally antifungal require additional radical surgical approach one infections related particularly dangerous rare facial infection great challenge clinicians surgeons seems accurate proper diagnosis impact patients survival post treatment quality life paper focus recent clinical findings treatment methods disease
influence day length living differs however possible duration inadequate index photoperiod low light sensitivity address issue authors tried estimate effective day length duration photoperiod exceeds certain threshold light intensity global solar radiation observation data gathered baseline surface radiation network sites converted data using efficiency model monthly average daily exceeding defined intensity calculated defined relationships monthly average global solar radiation investigated low light intensity showed relationship using relationships empirical models derived estimate effective day length different light intensities according validation model effective day length light intensity estimated accuracy less mean absolute percentage error estimation monthly base photoperiod recently number studies provided support link day length diseases results useful assessing relationships day length diseases
hiv aids first addressed security council seen successful process pivotal moment introducing human security however concern epidemic paired problems including issue security agenda fear vectors hiv reports involved sexual exploitation abuse added problems article aims understand gender informed efforts address issues forces security council challenges arose context article argues including issues security council agenda requires adjustment fit war logic drawing feminist theories security protection analysis shows security narrative hiv aids form coherent protection logic hiv aids constructed part problem interpreted gender equality reproduce military security
one leading medicine challenges prospects ahead related merely technology innovation clinical implementation also science communication context micrornas mirnas important part regulatory machinery number publications reporting mirna target interactions growing rapidly urgent need reporting study reports analysis published literature databases reporting validated first time best knowledge suggests solution way forward minimum information required standard reporting retrieved research reports pubmed web science dating downloaded information evaluated reporting extracted data complemented relevant genomic information suggest standard minimum checklist reporting consisting seven pertinent data types mirna gene target gene species experimental validation sequence variants associated phenotype additionally pubmed identification number systematic reviews meta analyses proposal reported enable faster development databases bioinformatics resources looking future efficient planning experimental designs field applications
interval timing crucial decision making motor control impaired many neuropsychiatric disorders previous studies examined timing various strains genetically altered mice parallel male female mice experimental setting investigated timing attention time male female mice presented gaps timed stimulus novel auditory presented interrupted timed stimulus gap combinations sex differences found regard timing accuracy precision however presentation gap combination timing males much smaller effect females strategy reported previously emotional previously paired neutral results reveal sex differences attentional gating switching working memory time elsevier rights reserved
important component plant defence response attack pathogens identify specific constructed cdna library using total rna genotype resistant tomato inoculated isolates race fusarium one clone isolated sequence analysis shows cdna clone encodes acidic isoform class iii southern blotting indicated present tomato genome real time quantitative pcr assay show expression gene induced upon infection accumulation transcripts protein rapid resistant genotype first putative role tomato defence fungal pathogens
objective study determine femoral cartilage thickness patients syndrome common sex chromosome disorder men varying degrees androgen deficiency cross sectional controlled study conducted tertiary care center participants male patients mean age years aged matched healthy male controls mean age years femoral cartilage measured ultrasonography three locations knee total testosterone estradiol sex hormone binding globulin free androgen index testosterone albumin levels measured femoral cartilage patients right left knee lateral mid medial statistically controls right left knee lateral mid medial respectively significant correlation sex hormones conclusion patients femoral cartilage relatively low testosterone levels patients altered estrogen metabolism explain increased cartilage thickness patients
although bone marrow fibrosis lethal condition underlying mechanism fully understood study aimed investigate pathogenesis fibrosis bone marrow histologic examination mast cell infiltration expression fibrosis associated cytokines analyzed bone fibrosis primary myelofibrosis pmf post essential thrombocythemia myelofibrosis syndrome mds bone marrow fibrosis immunohistochemical immunofluorescence performed using anti mast cell interleukin transforming growth factor beta tof beta antibodies number mast cells bone fibrosis significantly higher controls cases fibrosis versus control pmf versus control post myelofibrosis versus control mds versus control moreover bone higher fibrotic grades exhibited greater amounts infiltrating mast cells mast cells positive tgf beta bone fibrosis groups negative tgf beta post mds pmf weakly positive tgf beta negative groups negative tgf beta groups thus tof beta producing mast cells key players development therefore mast cells potential therapeutic targets treatment elsevier inc rights reserved
significant proportion solar irradiance reaches surface normally attenuated atmospheric properties conditions related rainy season solar model irradiance long term precipitation data used assess relationship mexico spatial analysis based morphological statistical criteria increased models certainty model explains irradiation variability observed ground average uncertainties clear conditions dry season days wet season meteorological data analysis shows total precipitation atypical temporal distribution slightly lower average deficit precipitation compared long term average found first half season later partially compensated deficit interpreted temporary delay high values precipitation based potential average irradiation model field observations concluded conditions related rainfall attenuated approximately incoming solar energy taking global energy balance account fraction higher comparison energy proportion reflected clouds results suggest high proportion energy attenuated atypical weather conditions local effects large scale phenomena southern oscillation
reducing energy consumption mandatory self powered sensor nodes wireless sensor networks obtain energy environment direction one first step optimize network accurately measure total energy harvested determine power available sensor consumption present technique based embedded circuit ultra low power microcontroller accurately measure efficiency flat panel solar thermoelectric generators operating environmental temperature gradients experimental tests showed voltage best case environmental flat panel solar thermoelectric generators applied input converter proposed technique eliminates measurement error compared conventional single strategy
paper proposes method three phase state estimation power distribution network including load tap voltage control tap positions essentially discrete variables point view estimation variables presents challenge proposed methodology combines discrete continuous state variables voltage magnitudes angles tap positions hybrid particle swarm optimization applied obtain solution method tested standard ieee bus unbalanced test system models proposed algorithm accurately estimates network bus voltage magnitudes angles discrete tap values based tap estimation provides accurate estimation losses network helps fair allocation cost losses overall cost electricity
paper introduces potential elements context model based development provides guidance future systems enhanced capabilities study based upon development six inter related projects specific environment supports standard techniques reuse sub specification inclusion shared repositories analyze experience discuss benefits limitations technique supported environment system architecture structure composition elements models specification languages decisive impact case elements defined specifications resulting reduction specification size inclusion sub specification facilitated modularity internal reuse specifications development time whereas reuse elements applications greatly benefited sharing repositories elements run time elsevier ltd rights reserved
current article deals preparation characterisation new complexes namely new complexes characterized various analytical spectral techniques structure ligand complex confirmed ray complexes used study toxicity stress resistance aging neuro protective effects taking model vitro free radical scavenging activity performed free radical scavenging assay complexes exhibited highest scavenging activity standard vitamin lifespan increased mutant treated complex complex triggered nuclear localization increases sod expression reduced amyloid beta protein induced observed present study confirmed oxidative stress resistance lifespan extension mutant showed potential ros scavenging activity complex results also confirmed effective anti aging potential complex developed therapeutic drug prevention aging age related neurodegenerative diseases studies required find exact action complex higher model elsevier rights reserved
previous studies shown self expansion increasing positive self content via engaging novel activities associated smoking cessation attenuated cigarette cue reactivity study examined whether self expansion associated better adherence weight loss physical activity outcomes within weight loss intervention participants shape island web based community wellness initiative took part randomized controlled trial involved week behavioral weight loss intervention baseline post intervention objective weights self reported self expansion obtained participants treatment adherence assessed objectively self expansion treatment significantly associated percent weight loss including clinically significant weight loss minutes treatment adherence results held controlling relevant covariates first study show self expansion associated better behavioral weight loss outcomes including weight loss adherence results suggest self expansion promising novel target future research inform health interventions
higher education associated healthy lifestyles health literacy remains unclear whether education shapes reactions varying levels genetic risk alzheimers disease study participants national genetic risk survey experiment received hypothetical genetic risk assessment ranging lifetime risk completed items cognitive perceived threat health emotional general negative affect anticipated behavioral seek information improve health behaviors engage public private action reactions risk individuals college education showed reactions increasing genetic risk approximately twice several times strong relative individuals lower high school education fact behavioral reactions significantly increase risk among education educational differences risk response older ages elsevier ltd rights reserved
present method computing ambient occlusion stack images scene fixed viewpoint ambient occlusion concept common computer graphics characterizes local visibility point much light reach point different directions without getting blocked geometry received surprisingly little attention vision show approximated using simple per pixel statistics image based simplified image formation model use derived measure compute reflectance illumination objects without relying additional demonstrate state art performance intrinsic images benchmark also demonstrate method several synthetic real scenes including printed objects known ground truth geometry
development custom ultrasonic instrumentation motivated need continuous real time monitoring possible mass flow measurement cooling systems atlas silicon instruments use pairs ultrasonic transducers transmitting sound measuring transit times opposite directions gas flow rate calculated difference transit times sound velocity deduced average gas composition evaluated comparison molar composition sound velocity database based direct dependence sound velocity component molar concentration gas mixture known temperature pressure instrumentation developed several geometries five instruments now integrated continuous operation within atlas detector control system dcs finite state machine one instrument monitors coolant pixel detector envelope molar resolution better indicated level cooling loops recently installed pixel detector operational another instrument monitors air new coolant sub percent precision recent effect introduction small quantity volume total volume system clearly seen instrument custom microcontroller based readout developed instruments allowing readout atlas dcs via tcp instrumentation many potential applications continuous binary gas composition required including hydrocarbon gas mixtures
operating system one causes runtime overhead high performance computing applications many high performance computing applications perform burst consume large amount memory linux kernel runs memory special kernel threads memory pages kernel threads frequently application performance degraded threads resource consumption increase applications page faults migration cpu cores study empirically analyze impact caused memory pages propose method reducing proposed method memory pages advance kernel thread pages one time kernel threads thus reducing frequency page impact conducted experiments using practical weather forecast software results showed proposed method minimized performance degradation caused
create possibilities sustainable wastewater management novel system consisting solid oxide fuel cells proposed study system integrated anaerobic digestion capture energy pollutants showed good performances removed ammonium nitrogen concentrated synthetic ammonium respectively accompanied hydrogen production converted recovered fuels biogas mixtures methane carbon dioxide electricity optimal conditions applied voltage internal electrode distance degrees operating temperature system achieved higher net energy output compared conventional systems estimated energy benefit proposed system showed net energy balance ratio enhanced existing system study local hong kong active landfill facility chemical oxygen demand cod additionally average inorganic ions heavy metals nutrient elements removed raw landfill cell results successful anaerobic processes energy extraction wastewater streams elsevier ltd rights reserved
optimize development include use theoretical simulators predict sun protection factor protection factor vitro measurements aims study assess correlations results obtained theoretical simulator observed vivo vitro results observed vitro vivo products different forms containing simulator software used evaluate theoretical performance formulations regarding protection determined formulations vivo measurements carried products forms compact foundations presence dye make results vitro less reliable due possible uneven film formation resultsthe results calculated simulator presented good correlation observed vivo absence good correlation presence calculated simulator also exhibited good correlation measured vitro formulations containing good correlation formulations containing correlation calculated simulator measured vivo formulations containing considered good addition measurements vivo presented good correlation values obtained vitro present study use simulator tests showed good correlations vivo results considered valuable resources development strategies des protection protection des vitro les les correlations les vivo vitro les vitro vivo les non des simulator performance des formulations protection les vitro vivo determines les formulations les vivo les les les presence des les des vitro possible formation film par simulator correlation vivo correlation presence par simulator correlation les vitro les formulations correlation les formulations des correlation par simulator vivo les formulations est les vivo correlation les vitro simulator des tests vitro correlations les vivo des des
early century witnessed green building san similar cities major property owners office towers green certification critically explored pay initiatives corporate social responsibility represent new attempt speculate upon green value within second nature cities however resource discovery requires highly partial view buildings socio natural beyond city illuminate efforts exploring experience green building san office tower successively served organizing vast resource periphery american west symbol driver transformation second nature financial resource right recently asset emerging global market green property
background quantifying gene expression single cell level fundamental complete characterization synthetic gene circuits due significant impact noise inter cellular variability systems functionality commercial set ups allow acquisition fluorescent signal single cell level flow quantitative expensive hardly affordable small laboratories methods protocol makes standard optical microscope able acquire quantitative single cell fluorescent data bacterial population transformed synthetic gene circuitry presented single cell fluorescence values acquired microscope set processed custom made software compared results obtained flow bacterial population transformed gene circuitry results high correlation data two experimental set ups correlation coefficient computed tested dynamic range proves standard optical microscope coupled appropriate software image processing used quantitative single cell fluorescence measurements calibration set together validation described conclusions experimental protocol described paper makes quantitative measurement single cell fluorescence accessible laboratories equipped standard optical microscope set ups method allows affordable measurement quantification intercellular variability whose better understanding phenomenon improve comprehension cellular behaviors design synthetic gene circuits required software freely available synthetic biology community microscope fluorescence single cell quantification
syndrome also known idiopathic intracranial hypertension characterized signs symptoms increased intracranial pressure headache cranial nerve absence space mass condition commonly affects overweight women childbearing age even also frequent men children children present atypical signs symptoms different prognosis compared adults however treatment children adults even strict treatment guidelines regards treatment strategies children based retrospective studies none evaluated prospective randomized controlled trial studies review focuses literature data treatment children
paper low voltage low dropout regulator designed simulated cmos technology converts input voltage stable regulated output voltage using spice circuit simulator two stage operational amplifier amp used error amplifier artificial colony abc evolutionary algorithm based demonstrated solving problem device sizing parameters amp optimization approach designing two stage amp circuit require analytical calculations handles non linear effects sub devices effectively designed tested change load current found power supply rejection ratio found khz mhz settling time less sec observed testing line load regulations
graphic algorithm time computer graphics based upon non boundary algorithm vector graphics proposed paper proposed algorithm divided three steps first eliminating boundary intersection vector graphics calculating effective second dividing graphics several parts finally determining whether part within boundaries achieving graphic besides demonstrated experiments compared traditional algorithm proposed algorithm clear simple effective applied widely furthermore proposed algorithm consumes seconds millions data memory consumption nearly unchanged
prove element discrete equation possesses infinity solutions changes sign least twice prove solves parallel parallel infinity infinity provided unique local minimum minimum int finally give criteria ensuring existence non existence periodic solutions multiple wells elsevier inc rights reserved
kind novel electromagnetic structure cross section proposed simulation implemented business microwave soft based finite integral technique fit electromagnetic field mode type wave guide belongs electromagnetic field intensity stronger near neck region areas electromagnetic patches lumped elements radar cross section smaller around absorbing property better around ghz difference comparing pure medium novel radiation structure cross section patches electromagnetic field value larger neck areas two half patches last potential application development structure put forward electromagnetic stealth technology design
novel approach stem cell generation attempt induce conversion adult somatic cells pluripotent stem cells called induced pluripotent stem cells introducing specific transcription factors two essential cell characteristics pluripotent long term cell renewal capacity additionally derived patient specific somatic cells thus ethical immunological issues aim study long term human neonatal fibroblasts new method using lipid nano particle technology reagent transfection system combination reprogramming vectors obtained characterized several sophisticated methods molecular biology microscopy distinct colonies started appear day reprogramming presence colonies proved alkaline phosphatase live staining manual colonies subsequent lose ability form bodies positive moreover obtained expressed markers expression levels osteogenic markers significantly higher comparison control summary demonstrated long term human neonatal fibroblasts analysis concerns biological safety used patient specific cells regenerative medicine
radio communications possessing high signal quality long distance propagation traditionally difficult achieve reliably bands mhz due analog modulation schemes use vulnerability radio atmospheric disturbances development digital radio drm standard provided digital coding methods audio compression data protection features transmissions drm nations reliable high quality long distance transmission technology lower cost satellite radio services development versatile drm receivers therefore necessary paper presents design drm receiver capable single drm transmission channel compares receivers performance commercial receiver plans future improvement receivers overall signal noise ratio resilience signal discussed including addition multi channel reception capability maximum ratio combining diversity algorithm
work deals optimizing methodology fabrication metallic nanoparticles active microbes using core amine based novel double amine type copper nickel cobalt synthesized characterized elemental analysis fourier transform infrared spectroscopy ftir nuclear magnetic resonance nmr thermogravimetric analysis tga study structures various carried thermodynamics parameters reverse also estimated process spontaneous entropy driven prepared utilized precursors fabrication metallic nanoparticles nps method validated three studied transition metals preparation metallic nanoparticles approach offers better results terms size shape morphology distribution stability nps characterization nps done vis ray diffraction xrd transmission emission microscopy tem dynamic light scattering prepared nps antimicrobial activity three pathogenic microbes viz bacillus gram bacterium gram bacterium fungus best results shown nps furthermore interaction metallic nps bovine serum albumin estimated published elsevier
objectives identify effective aerobic exercise programs provide clinicians patients updated high quality recommendations concerning traditional land based exercises knee osteoarthritis methods systematic search adapted selection criteria included comparative controlled trials strengthening exercise programs patients knee osteoarthritis panel experts reached consensus recommendations using delphi survey hierarchical grading system used based statistical significance clinical importance improvement results five high quality studies included demonstrated various aerobic training exercises generally effective improving knee osteoarthritis within week period aerobic exercise program demonstrated significant improvement pain relief grade physical function grade quality life grade aerobic exercise combination strengthening exercises showed significant improvement pain relief grade physical function grade grade conclusion short term aerobic exercise program without muscle strengthening exercises promising reducing pain improving physical function quality life individuals knee osteoarthritis
background neonates expected weight loss first days life many factors considered affect newborn weight loss breastfeeding adequacy maternal parity intravenous fluids administered labor environmental factors studies yielded variable results primary objective study assess pattern newborn weight loss initial birth factors affecting secondary objective assess impact initial weight loss neonatal beyond birth weight day life materials methods study carried term exclusively newborn neonates initially birth regularly hourly intervals data pertaining various maternal factors affecting neonatal weight loss birth weight newborns adequacy breastfeeding recorded weight neonates day also recorded results lost birth weight lost maximum weight loss occurred life mean standard deviation percentage weight loss inadequate breastfeeding compared adequately mean percentage weight loss born neonates developed significant mean percentage weight loss compared rest subgroup lost birth weight birth weight day life compared subgroup weight loss conclusion regular monitoring weight exclusively potentially useful particular attention need given mothers lose weight
interest many applications involve electron transfer absorption light solar energy cancer therapy newly synthesized characterized using nmr nmr vis fluorescence spectroscopy maldi tof tof high resolution mass spectrometry standard nmr nmr experiments coupled nuclear effect experiments confirmed structure compound expected ions observed maldi tof tof mass spectrum vis absorption spectrum shows band three bands molar respectively excitation gives emission quantum yield
thrombocytopenia myelofibrosis renal dysfunction syndrome variant disease describe year old man presented persistent fever negative human immunodeficiency virus human virus computed tomography scan showed anterior mass small although biopsy anterior showed fatty tissue lymphocytes biopsy left lymph node revealed vascular type disease subsequently developed severe thrombocytopenia renal dysfunction addition bone marrow biopsy showed myelofibrosis syndrome diagnosed based lymph node pathology characteristic manifestations syndrome glucocorticoid therapy achieved complete remission regression mass knowledge first report syndrome accompanied anterior mass responded therapy
reducing latency distributed computing data storage systems gaining increasing importance several empirical works reported efficacy scheduling redundant requests systems one reduce job latency scheduling job one server waiting fastest responds several theoretical models proposed explain power using redundant requests existing results rely heavily common assumption redundant requests job immediately soon one completed study one schedule redundant requests assumption hold great importance practice since cancellation running jobs typically non negligible delays order bridge gap existing models practice propose new model captures cancellation delays find one schedule redundant requests achieve optimal average job latency new model results show even small cancellation overhead actual optimal scheduling policy differs significantly optimal scheduling policy overhead zero furthermore study optimal dynamic scheduling policies appropriately schedule redundant requests based number jobs system analysis reveals two server case optimal dynamic achieve lower average job latency compared optimal static
safety climate safety culture organization dynamic nature reflects employees perceptions attitude towards existing safety practices construction projects main goal paper evaluate differentiate construction projects based safety climate determine significant constructs safety climate paper develops model predict safety climate construction project based artificial neural network ann important constructs safety climate determined literature review constructs safety climate used inputs safety climate project used output ann algorithm study collected total responses questionnaire survey across country three layer feed forward back propagation neural network utilized analysis developed model predicts safety climate construction project reasonably based sensitivity analysis commitment environment proposed significant constructs safety climate moreover projects ranked respect safety climate using model projects easily identified normal probability technique thus model prove helpful clients contractors evaluate predict safety climate thereby managing safety effectively construction projects american society civil engineers
paper introduces new method improve reliability confidence level defect depth measurement based pulsed inspection addressing fitting problem different existing methods using fixed model structure pixels proposed method adaptively detects optimal model structure pixel thus targeting achieve better model fitting using less model terms results numerical simulations real experiments suggest new method able measure defect depth accurately without pre set model structure error usually within snr comparison existing methods number model terms signals snr epsilon snr snr data length least data points times characteristic time usually produces best results authors published elsevier ltd
gene transformed sativa agrobacterium mediated transformation method salt tolerance transgenic assessed among plants obtained transformation positive polymerase chain reaction pcr detection using primers specific gene reverse transcription polymerase chain reaction pcr analysis indicated gene expressed plants transcriptional level southern blotting analysis also showed target integrated genome transgenic plants grew vigorous salt stress condition whereas wild type plants survive relative electrical conductivity malondialdehyde mda contents transgenic plants lower peroxidase superoxide dismutase sod activities higher wild type plants results demonstrated expression foreign gene enhanced salt tolerance transgenic
recent studies construction material technology indicated soil reinforcement improves resistance soil compression tension due wide use geotextile reinforcement road construction potential benefit geotextile reinforcement cyclic loading investigated study performed series cyclic tests examine dry sand reinforced geotextile subjected dynamic loading tests conducted reinforced unreinforced dry sand sand mixed varying amounts main factors affecting cyclic behaviour arrangement number geotextile layers confined pressure content examined discussed paper results indicate geotextile inclusion increased pressure increase axial modulus decreased cyclic dry sand contents examined also found increasing content percent axial modulus reinforced unreinforced sand decreased cyclic increased increases content values increased cyclic axial modulus decreased cyclic elsevier ltd rights reserved
several immunologic mediators interleukin small molecules janus kinase implicated pathogenesis atopic dermatitis evidence shown blocking mediators help modify disease process several new topical medications developed target enzyme recently approved food drug administration fda treatment atopic dermatitis phase studies completed phase iii clinical trial results systemic medication inhibitor receptor subunit inhibits signaling currently reviewed fda published medical communications
cardiac control linked physical mental health one critical aspect health received much attention sleep hypothesized adults higher high frequency heart rate variability exhibit better sleep quality assessed pittsburgh sleep quality index objectively measured healthy young women extended neutral film participants underwent full obtain objective measures sleep quality night sleep expected higher resting associated higher subjective objective sleep quality shorter sleep latency fewer sleep overall separated sleep phases showed less consistent relationships sleep quality findings indicate high key predictor healthy sleep authors published elsevier open access article license http creativecommonsorg licenses
study methodology presented demonstrated combined estimation regional specific yield distributed recharge using double water table fluctuation technique geographical information system gis hard rock aquifer system semi arid regions study area divided zones groundwater budget components computed wet dry seasons using year period data zone regional specific yield estimated applying technique dry seasons rainfall recharge estimated applying technique wet seasons zone wise rainfall recharge relationships established using regression technique thereafter specific yield recharge estimates used gis generate maps surface water bodies found significantly contribute groundwater recharge finding underscores need adopting rainwater harvesting study area enhance recharge regional specific yields found range whereas mean rainfall recharge found vary box plots scale transformed specific yield revealed greatest spatial variation spatial temporal variations rainfall recharge study area statistically significant developed rainfall recharge relationships found highly significant ten zones insignificant remaining zones international association hydro environment engineering research asia pacific division published elsevier rights reserved
theory problem solving one emerging creative problem solving methodologies paper proposes way simplify electrical domain usage making feel less complex relevant understand able users specific sector research takes dynamic voltage device case electrical engineering domain demonstrate proposed based guidance framework development assist solving problems devices proposed sector specific guidelines particular segment electrical engineering power quality device closer particularly linked key parameters sector using derived guidance framework field engineers basic knowledge apply design problem solving purpose
novel permanent magnet machine dual rotors proposed order improve operation performance underwater vehicle anti rotation propulsion system substantially simplify system structure decrease volume reduce mass cost moreover improve reliability without slip ring idea principle electromagnetic design provided order meet power angle characteristic corresponding uniform similar inner rotor permanent magnet machine unit outer rotor permanent magnet machine unit magnetic field stator flux density air gap flux density inductance load back torque angle characteristic obtained finite element method prototype designed built tested method detecting load back search coils proposed validity verified fea results experimental measurements
present study defined simplified physiologically based pharmacokinetic model humans based vitro metabolic parameters determined using relevant liver microsomes coefficients derived silico physiological parameters derived literature prior previously developed model rats model basically consists chemical absorption compartment compartment central compartment evaluation previous rat model performed comparisons experimental pharmacokinetic values blood urine obtained rats vivo oral treatment observed adverse effect level days elimination rates vitro established using data rat liver microsomes pooled human liver microsomes expected absorbed rapidly body silico case rats confirmed experimentally vivo repeated low dose treatments results indicate simplified model useful forward approach humans model also useful simulating blood concentrations related compounds resulting exposure low chemical doses elsevier inc rights reserved
paper going investigate insulin bio molecule responsible onset diabetes generally diagnosed using conventional elisa method concentration blood short life time challenge developing sensor sensitive small volumes paper presents experimental study dielectric properties buffer solution varying concentration insulin peptide hormone microwave frequency range composite electric mode microwave dielectric resonator sample holding disc used ghz observations part permittivity found sensitive changes insulin concentration ranging studies show present method potential detect sense concentration regression coefficient sensitivity change insulin concentration
studied occurrence presentation disease course effect adjunctive dexamethasone prognosis bacterial patients using immunosuppressive medication patients selected nationwide prospective cohort community acquired bacterial performed march october eighty seven episodes bacterial occurred patients using immunosuppressive medication consisted corticosteroids patients bacterial using immunosuppressive medication less likely present headache neck stiffness compared immunosuppressive medication episodes csf leukocyte count csf cultures revealed episodes outcome unfavorable episodes death occurred episodes adjunctive dexamethasone administered episodes mortality tended lower adjunctive dexamethasone therapy compared without dexamethasone therapy conclude bacterial patients using immunosuppressive medication likely present atypical clinical laboratory features often caused atypical bacteria mainly adjunctive dexamethasone widely prescribed patients associated harm study
young latino gay bisexual men experience discrimination due racism within beyond communities although research overt forms discrimination growing body research examining effects indirect forms discrimination racial sexual minorities purpose study explore contexts various types describe resilience strategies used young adult latino gay bisexual men living los california sample young latino gay bisexual men aged recruited complete qualitative depth semi structured interviews following phenomenological approach three contextual themes relevant emerged three themes emerged around resilience strategies overcome experiences self discovery adaptive self advocacy family community based efforts reinforce expand resilience needed help young latino gay bisexual men des mis les discrimination examine les micro des discrimination les les des types micro les strategies resilience par les los population ages des semi structures themes relevant micro emerge les micro les micro les micro themes emerge strategies resilience experiences adaptive des efforts repertoire des strategies resilience les los mas los micro los micro los los california con los los para con para micro micro micro micro para adaptable para los con los
pursuit identify reversible selective inhibitors two series based binding core identified structure activity relationship sar exploration led identification two advanced lead molecules demonstrated desired inhibitory potency different cellular assays excellent selectivity panel diverse kinases favorable vivo properties mice anti effect mouse model elsevier ltd rights reserved
background known high prevalence genetic clinical syndrome diagnoses paediatric cardiac population disorders often effects important impact neurodevelopmental outcomes taken together facts suggest patients families benefit consultation genetic specialists cardiac neurodevelopmental clinic objective study assessed burden genetic disorders utility genetics evaluation cardiac neurodevelopmental clinic methods retrospective chart review conducted patients evaluated cardiac neurodevelopmental clinic december april patients seen cardiovascular genetic counselling support results total patients included study patients pre existing genetic diagnosis following genetics evaluation additional given new clinical laboratory confirmed genetic diagnosis including environmental exposures associations chromosomal disorders single gene disorders genetic testing recommended patients radiological imaging screen congenital anomalies patients medical referrals patients non genetic clinical laboratory testing patients syndrome specific guidelines available followed patients known diagnosis american academy pediatrics red book guideline recommendations given five patients family based cardiac screening recommended families affected left ventricular outflow tract obstruction conclusion genetics involvement cardiac neurodevelopmental clinic helpful identifying new diagnoses providing syndrome specific care impact patients overall health status neurodevelopmental outcome
paper propose three dimensional two level locality aware parallel image mesh conversion algorithm algorithm exploits two levels parallelism different coarse grain parallelism region level mapped node multiple cores medium grain parallelism cavity level mapped single core employ data locality aware mesh refinement process reduce latency caused remote memory access evaluated cache coherent distributed shared memory dsm machine pittsburgh center observed weak scaling efficiency almost roughly cores compared previous algorithm parallel mesh generation algorithm best knowledge exhibits best scalability parallel mesh generation algorithms running dsm elsevier rights reserved
numerical model developed system consisting liquid plug oscillating tube closed one end connected reservoir constant pressure end represents basic configuration heat pipe thermally driven self sustained oscillations system result evaporation condensation phenomena occurring two zones tube separated section one cooled heated simultaneously modelling principles system posed previous works work equation describing liquid film evaporation substantially improved light recent experimental results thickening film shortening length due evaporation triple line taken account furthermore transient heat conduction equation solved tube liquid film order calculate temperature key parameter model moreover experimental bench presented measure pressure variations inside oscillating liquid results show classical correlations fluid mechanics relevant model oscillation system finally parametric study carried understand influence thermal properties liquid tube start system thermal materials found important criterion indicate conditions oscillations self sustained elsevier masson sas rights reserved
robotic highly coupled nonlinear systems wherein time varying parameters uncertainties adversely affect characteristics response systems hence systems require effective robust controller handle complexities difficult challenge control engineers paper presents two layered fractional order fuzzy logic controller scheme two link planar rigid robotic payload trajectory tracking task optimal design controller parameters proposed scheme obtained potential meta heuristic technique named search algorithm csa order ensure effectiveness performance proposed compared integer order design approach two layered single layered conventional proportional integral derivative pid controllers robustness testing carried parameter variations external disturbance rejection elsevier rights reserved
one important topics morphometry received high attention recently longitudinal analysis shape variation according definition shape shape object non euclidean space making longitudinal study configuration difficult however simplify task objects constructing non parametric regression type model unit sphere pursued paper prediction configurations time instances done using properties size great moreover minimizing euclidean risk function proposed select feasible weights constructing functions non parametric smoothing manner provide proper shape growth models analysis objects varying time proposed models applied analysis two real life datasets
study objective using qualitative method purpose study obtain information directly adolescents attitudes knowledge regarding emergency contraception investigate presence differences male female participants attitudes knowledge design participants study consisted single sex focus groups adolescents male female aged years conducted among high schools regions italy results data analyzed thematic analysis taking account gender differences main themes emerged first labeled adolescents attitudes toward emergency contraception divided aware life line child second theme labeled adolescents knowledge toward emergency contraception divided false baseline information just take conclusion italian adolescents believed important prevent risk unprotected sex using contraceptive methods motivation use emergency contraception related critical attitudes toward consequences ineffective contraception although adolescents awareness emergency contraception comprehensive knowledge needed findings inform specific interventions aimed educating adolescents need emergency contraception
structural brain abnormalities demonstrated schizophrenia include volume regions temporal lobe comprise primary olfactory cortex olfactory impairments hallmark schizophrenia precede onset illness distinguish adolescents experiencing prodromal symptoms healthy youths predict transition psychosis therefore examined temporal lobe regional volumes large adolescent sample determine structural deficits temporal lobe areas associated schizophrenia also heightened risk psychosis seven temporal lobe regional volumes amygdala hippocampus inferior temporal gyrus gyrus superior temporal gyrus temporal pole cortex measured psychosis spectrum adolescents adolescents types psychopathology healthy adolescents philadelphia cohort total intracranial left volumes smallest among psychosis spectrum measures distinguished groups left also smaller psychosis spectrum compared healthy subjects volume strongly correlated impaired cognition less robustly associated heightened negative symptoms volume correlated positive symptoms special abilities temporal lobe volumes classified psychosis spectrum youths high specificity relatively low sensitivity mri measures therefore serve important confirmatory biomarkers preclinical trajectory among risk youths specific pattern deficits predict specific symptom profiles
belong vitamin group based parental compound acid involved important biochemical processes like dna synthesis repair composed ring acid glutamate moieties human metabolism able synthesize therefore obtain diet synthetic vitamin used food low price relative stability increased bioavailability compared natural forms known sensitive compound easily aqueous solution ultraviolet visible light towards various products irradiation process preservation foods uses accelerated electrons gamma rays rays irradiation proposed treatment various food products eliminating reducing pathogens insects increasing storage time replacing chemical study concerns identification degradation products beam irradiation aqueous solutions irradiated van electrons beam accelerator current scan width dose rate applied doses control absorbed doses monitored elsevier ltd rights reserved
gaussian process models provide flexible nonparametric approach modeling location time indexed datasets however storage computational requirements models large spatial datasets nearest neighbor gaussian processes hierarchical nearest neighbor gaussian process models large datasets stat provide scalable alternative using local information nearest neighbors scalability achieved using neighbor sets conditional specification model show equivalent sparse modeling factors large covariance matrices also discuss general approach construct scalable gaussian processes using sparse local present multivariate data analysis demonstrates nearest neighbor approach yields inference indistinguishable full rank despite several times faster finally also propose variant model selection neighbor set size wiley periodicals inc
rapid advances field computational genomics bioinformatics motivated development innovative engineering methods data acquisition interpretation analysis help later methods many processes molecular biology modeled analyzed identification discovery coding regions genomic structure using computational algorithms clear example processes work proposes novel application known principles concepts communications theory digital signal processing detection protein coding regions genomes proposed algorithm employs complex mapping scheme provide numerical representation genomic sequences involved analysis utilizes concepts communications theory correlation maximal ratio combining algorithm filtering generate signal whose peaks coding noncoding regions respectively proposed algorithm applied several genome sequences two bayesian classifiers designed evaluate performance proposed algorithm obtained simulation results show algorithm able efficiently accurately identify protein coding regions sensitivity specificity values comparable known gene detection methods proves relevance using communications theory concepts genomic sequence analysis elsevier ltd rights reserved
recent interest impact emotional expressions computers peoples decision making however despite growing body empirical work mechanism underlying effects still clearly understood address issue paper explores two kinds processes studied emotion human human interaction processes whereby people retrieve information emotion expressions others beliefs intentions affective processes whereby emotion expressions emotions others influence decisions apart two processes occur human computer interaction looked physiological measures activity heart rate present two experiments participants engaged social embodied agents expressed emotion results show first peoples decisions influenced affective cognitive processes according prevailing process people differently formed contrasting subjective ratings agents second show individual trait known measures peoples physiological sensitivity predicted extent affective processes dominated interaction discuss implications design embodied agents decision making systems use emotion expression enhance interaction humans computers elsevier ltd rights reserved
several researchers around world studied gesture recognition recent techniques fall dimensionality useful real time environment study proposes system dynamic gesture recognition prediction using innovative feature extraction technique called approach proposed method generates smaller feature vector describe hand shape minimal amount data dynamic gesture recognition prediction system implements two independent modules based hidden markov models dynamic time two experiments one gesture recognition another prediction executed two different datasets dynamic gestures dataset hand data results showed discussed elsevier inc rights reserved
host associated perform many beneficial functions including pathogens training immune system show developing lose substantial skin bacterial diversity primarily due reduced ongoing input environmental sources combined studies wild database strains allows examine antifungal function skin microbiome tracked skin bacterial communities across time points four probiotic treatments two exposures lethal fungal pathogen compared samples collected wild populations life stage lost inhibitory bacteria time proportion individuals exposed became infected rose subsequent exposures inhibitory probiotic resulted increase survival second challenge indicating effect microbiome depletion reversible restoring inhibitory bacteria taken together study highlights functional role ongoing environmental inputs skin associated bacteria mitigating devastating pathogen long term decreases defensive function
recently number smart material investigated widely used civil construction industries present study investigates application smart semi active piezoelectric friction damper made piezoelectric material seismic control curved bridge isolated lead rubber bearing main aim study investigate effectiveness hybrid system find optimum parameters seismic control curved bridge selected curved bridge continuous three span concrete box girder supported rigid located deck radial directions bridge excited four different earthquake ground motions three components two horizontal vertical different characteristics observed use semi active quite effective controlling response curved bridge compared passive system incorporation smart damper requiring small amount energy addition isolation system used effective control curved bridge dynamic loading
background despite several studies periodic leg movements healthy sleep data prevalence characteristics periodic arm movements normal subjects lacking aimed investigate association sleep healthy subjects methods ninety one participants underwent video according american academy sleep medicine criteria addition standard registration data muscles recorded results sixty two subjects index median index range seven subjects index sleep median index sleep range cases coincident sleep evident correlation weak moderate spearmans rho sleep spearmans rho conclusion healthy subjects occur predominantly apparent true contrast classical present true periodic phenomenon rather random voluntary movements meeting wide range criteria authors published elsevier
objective review pharmacology efficacy safety treatment lymphoid malignancies data sources literature search performed pubmed medline databases september abstracts american society american society clinical oncology ongoing studies searches performed utilizing following key terms bcl inhibitor study selection data extraction studies pharmacology pharmacokinetics clinical efficacy safety lymphoid malignancies identified data synthesis recently treatment cell disorders shifted conventional cytotoxic chemotherapy novel small molecule inhibitors advent recently food drug administration approved oral agents shifted paradigm chronic lymphocytic leukemia treatment however complete remission uncommon outcome patients progressing treatments remains poor attention focused novel target cell lymphoma protein bcl serves essential role regulation apoptosis demonstrated efficacy multiple subtypes lymphoid malignancies including patients relapsed refractory harboring deletion overall response rate nearly generally tolerated significant adverse effect tumor syndrome formal management recommendations conclusion demonstrated promising results relapsed refractory lymphoid malignancies acceptable adverse effect profile role bcl inhibition various malignancies becomes elucidated offer benefit myriad patient populations
background psoriasis chronic immune mediated disease affects world population ultraviolet effective treatment psoriasis compared systemic treatments currently lack easily accessible online patient educational material regarding form treatment objective present freely available online guide video treatment informative patients increases success compliance patients starting therapy methods treatment protocol used university california san psoriasis skin treatment center available information literature reviewed design comprehensive guide patients receiving treatment results created guide video resource reviews fundamentals safety considerations flow treatment side effects post skin care conclusion guide serves valuable resource patients preparing clinicians treat learn form therapy
density functional theory dft become routine tool computation electronic structure physics materials chemistry fields yet application traditional dft problems biological sciences hindered large extent scaling computational effort system size review major software functionality advances enable electronic structure calculations performed systems comprising many thousands atoms describe early applications large scale dft computation electronic properties structure biomolecules problems enzymology photosynthesis computer aided drug design review hope demonstrate first principles modelling biological structure function relationships approaching reality
due large magnetic relevant air gap leakage inductance main inductance surface mounted permanent magnet machine major components leakage inductance known harmonic leakage slot leakage inductance paper proposes analytical method determine two leakage components fractional slot concentrated winding machine arbitrary phase number comparison machine design distributed winding number poles fundamental flux linkage done comparison done machines double layer single layer winding layout
background evaluation medication efficacy safety essential guarantee successful therapeutic outcome public health practices however larger distribution chain supply developing countries often challenged drugs poor manufacturing storage degradation leading health patient adverse consequences yet access supply chain management strengthening quality assurance outcomes remains poorly documented patients enrolled free medications little documented quality assurance validity safety affected populations along supply chain management since methods cross sectional study conducted distribution units centers central south west regions drugs samples included fixed dose combinations drugs packaging labeling assessed assays performed national laboratory quality control medications expertise results study covered structures located eight different including central store two regional pharmaceutical procurement centers thirteen hiv approved treatment centers management units total products collected eight drugs containing presented white tablets however drugs standard tests performed others products standards assays performed conclusion concluded drugs freely accessible distributed good quality however increase number patients since adoption test treat approach reach goals implementation new national antiretroviral regimen guidelines molecules boosted protease inhibitors continuous quality control assurance surveillance monitoring evaluation recommended assessment quality formulations susceptible degradation pediatric formulations rising multidrug resistance trend also desired
aim cross sectional study analyse quality life socio demographic characteristics family support satisfaction health services effect integrative community therapy among non elderly adults without symptoms depression state brazil data elderly adults without depressive symptoms compared instruments used mini mental state examination short version geriatric depression scale clinical socio demographic questionnaire version world health organisation quality life questionnaire family assessment device patient satisfaction mental health services rating scale elderly adults depressive symptoms lower quality life social relations domain without depressive symptoms addition compared without depression fewer elderly adults depressive symptoms attended integrative community therapy also reported low degree family involvement problem solving showed regarding satisfaction health services results important implications decision making process regard strategies improving health status elderly adults depressive symptoms
little evidence barriers pain management relationships pain outcomes patients cancer purpose study determine barriers reported patients cancer caregivers relationships demographic characteristics patients pain cross sectional study used selected baseline data ongoing randomized clinical trial patient lay caregiver dyads receiving home level care participants used internet enabled tablet complete valid reliable measures pain intensity pain management barriers barriers questionnaire items demographic characteristics responses indicate areas highest concern mean scores patients caregivers pain means disease progression constipation additionally areas highest concern mean scores caregivers addiction pain medicine causing one things confusion mean scores ranged averaged patients ranged averaged caregivers mean barrier scores remain high different patients caregivers significantly related patients pain intensity however differences race ethnic setting barrier scores patients hispanic heritage reported higher barrier scores non hispanic patients together findings support prior research findings also contribute new insights pain intensity pain barriers relevant serving minorities cancer
background compulsive exercise proposed significant etiology development maintenance eating disorders eds resulting severe enduring pathology however studies investigated longitudinally adolescents eds aimed test adolescents show associations clinical variables previous research found adults methods three thousand one hundred sixteen girls boys clinical database investigated regarding prevalence frequency relation psychiatric symptoms associated features outcome denial illness common among adolescents therefore adjusted results adjusted prevalence girls prevalent bulimia nervosa previously found adults scored significantly higher non total severity level restriction negative however minor differences non patients emotional distress hyperactivity suicidality self esteem among boys adjusted prevalence boys scored significantly higher non total severity initial influence year outcome although cessation associated remission conclusions common clinical feature adolescents eds cessation associated remission controlling denial illness less detrimental impact predicted recommend controlling denial studies adolescents exploration classification treatment implications
globulin often included conditioning regimen prevent graft host disease allogeneic hematopoietic stem cell transplantation however contains antibodies targeting wide range antigens human cells potential target effects remain concern explored question humanized mice permit analysis human cell depletion tissues showed binds almost lineages human hematopoietic cells including accordingly capable almost human hematopoietic cells interestingly efficacy highly variable depending tissue residence human cells bone marrow significantly less susceptible blood spleen recovery human humanized mice received weeks transplantation indicates minimal effect human bone marrow however efficient human depletion failure seen mice receiving time transplantation data indicate efficacy tissue dependent suggest potential risk donor hematopoietic used conditioning molecular immunology published online october
aortic valve results aortic flow blood left ventricle observed work characterized detailed changes intra ventricular flow result physiological vitro left heart simulator loss energy within level increased also assessed validated consisted clear flexible wall modular two component planar digital particle image velocimetry used visualize quantify intra ventricular flow large coherent structure whole observed control conditions cases jet observed generate kinematic obstruction valve preventing trans jet generating coherent structure jet also observed wall energy dissipation rate trace mild moderate found respectively study first time performed vitro characterization flow presence mechanistically formation kinematic obstruction appears cause increased metric vivo increases non linearly fraction potentially used metric grade severity develop clinical interventional timing strategies patients
introduction human genome scale metabolic reconstruction details known metabolic reactions occurring humans thereby holds substantial promise studying complex diseases phenotypes capturing whole human metabolic reconstruction going task since last community effort generated consensus reconstruction several updates developed objectives report new consensus version integrates various alternative versions significant additional updates addition establishing consensus reconstruction key objectives included providing comprehensive annotation metabolites genes ensuring full mass charge balance reactions developing model correctly predicts atp production range carbon sources methods developed combination manual automated error checking specific significant manual updates include fatty acid metabolism oxidative phosphorylation coupling electron transport chain atp synthase activity metabolites definitive chemical formulae charges specified used ensure full mass charge reaction balancing automated linear programming approach additionally improved integration proteomics data facilitated updated relationships genes proteins reactions results now represents predictive model human metabolism date demonstrated extensive manual increased reconstruction size metabolites reactions associated genes now mapped single standard focus upon mass charge balancing reactions along better representation energy generation produced flux model correctly predicts atp yield different carbon sources conclusion updates achieved complete best annotated consensus human metabolic reconstruction available thereby increasing ability resource provide novel insights normal disease states human model freely available database http
systematically reviewed differences hippocampal amygdala volumes adults childhood maltreatment related posttraumatic stress disorder ptsd healthy controls using terms adults mri magnetic resonance imaging posttraumatic stress disorder ptsd child abuse child maltreatment conducted searches several electronic databases identified studies met inclusion criteria included meta analysis hippocampal volume included meta analysis amygdala volume mean hippocampal amygdala volumes used determine effect sizes found bilateral reduction hippocampus amygdala ptsd group compared healthy controls effect sizes left right hippocampus left right amygdala respectively confidence intervals left right hippocampus respectively amygdala confidence intervals left right amygdala relatively studies available analysis limitation additionally sex diverse mri studies ptsd needed determine whether sex plays significant role hippocampal effects associated childhood onset trauma elsevier ireland ltd rights reserved
bioactive protein extract containing known activity present study aimed assess safety aspect preclinical setting included observation toxic signs acute repeated drugs effect prenatal development drug interaction acute toxicity study high dose level tolerated toxicity study doses per day mortality observed parameters observed normal prenatal developmental toxicity observed adverse effect level observed moderate dose aspirin cause gastric lesions except three drugs taken together results present study suggested safe long term administration caution high dose used pregnancy used combination one antiplatelet drugs
low back pain various etiologies common clinical presentation young athletes article discuss utility bone evaluation low back pain young athletes spectrum lower spine lesions caused sports injuries bone scan presented along strategies avoid unnecessary irradiation young patients also covered pitfalls diagnosis due referred pain phenomenon normal skeletal variants specific age group
availability heterogeneous cpu gpu systems opened door new opportunities development parallel solutions tackle complex biological problems reconstruction evolutionary histories among species represents computational challenge addressed exploiting kind hardware designs research study application heterogeneous computing accelerate one known objective functions inferring phylogenetic function purpose undertake design cpu gpu kernel implementations relevant function proposing heterogeneous cpu gpu approach multiple evaluations among processing devices experiments real nucleotide data sets comparisons parallel implementations give account benefits proposal paper obtaining significant parallel results combining cpu gpu capabilities accordance characteristics input data
design combined pulmonary drug delivery holds great promise treatment respiratory tract disorders particular targeting dendritic cells key immune cells enhance suppress immune response lung promising approach treatment allergic diseases encoded poly alcohol coated gold nanoparticles functionalized either negative positive surface charges functionalized sign antibody particle surface enabling binding dendritic cell surface receptor model consisting epithelial immune cells macrophages dendritic cells mimicking human lung epithelial tissue barrier employed assess effects showed higher uptake compared counterparts highest uptake recorded macrophages shown flow cytometry none induced cytotoxicity necrosis increased cytokine secretion whereas induced higher apoptosis levels sign showed significantly increased uptake monocyte derived dendritic cells subsequent activation compared non antibody conjugated control independent surface charge results show sign conjugation enhanced targeting activation complex lung cell model findings highlight potential approaches targeting activation immune cells lung
purpose evaluate criterion validity diagnostic utility brief eating disorder screening instrument mexican sample methods study conducted two phases phase involved administration self report measures eating disorder inventory students aged years age female three colleges san mexico phase random subsample students participated eating disorder examination structured interview yields diagnoses analyses conducted evaluate criterion validity examining correlations scores ability differentiate diagnosed cases non cases results subscales showed high correlations scores proving initial evidence criterion validity score two points optimized sensitivity specificity cutoff correctly classified half cases screened majority non cases providing evidence criterion validity analyses repeated separately men women yielding gender specific information performance conclusion taken whole results indicated useful tool identifying mexican university students risk eating disorders
analyze narratives people diagnosed adhd attention deficit hyperactivity disorder bpd borderline personality disorder search new evidence improved efficacy treatments environments evidence suffering particularly social suffering revealed reality great presence narratives necessarily considered new paths improve therapeutic procedures conventional treatment aimed towards healing people research experience propose understand stories evidence clinic narratives suffering become healthcare quality documents allowing evaluating improving practices incorporating different social understanding disorders perspective implemented social approach based particular way social theory emotions emotions ethnographic narrative materials analyzed relate mainly author conducted author past five years spain mexico
background hereditary vitamin resistant autosomal recessive disorder caused mutations vitamin receptor gene variable phenotypes associated mutations linked effects interacting partners mainly retinoic receptor methods examined four patients three unrelated families parents normal phenotype used sanger sequencing identify mutations coding exons results two homozygous mutations exon gene identified phenotype genotype association possible even mutation seen mutation despite comparable bone disease patients showed different responsiveness large doses alpha hydroxy vitamin supplementation conclusions first report mutations promising clinical outcomes despite severity phenotypes
cmos current mode analog multiplier circuit presented suited standard cmos fabrication successfully employed wide range analog signal processing applications measurement results cmos test chip prototype verify approach employed circuit consumes using single supply voltage requires silicon area
caused serious disease plants worldwide earlier phylogenetic studies using genes revealed related many collectively referred present study report genome sequences compared four available public domain tree based marker genes form cluster suggesting origin common analysis using type strain established belong one species clonal analysis core genome revealed presence two major lineages within cluster consisting clonal variants majority first noticed india clonal relationship common origin comparative analysis revealed open pan genome role genomic flux since diversification common even though wide variations type iii gene identified three core effectors valuable resistance breeding programs overall genomic examination ecological relatives allowed dissect tremendous genomic potential species rapidly evolve specialized strains infecting diverse crop plants importance host specialization one characteristic features highly evolved pathogens group bacteria since hosts involve crops economically important fruits detailed understanding diversity evolution strains infecting diverse plants important purposes present study carried genomic investigation members ecologically defined group strains pathogenic diverse plants including group includes oldest also recently emerged particular country endemic high throughput genomic study provided novel insights evolution unique lineage consisting serious pathogens ecological relatives suggesting nature scope pattern rapid recent diversification level species clonal variants study revealed interesting genomic patterns diversification lineage perhaps careful study host range included
purposes study evaluate psychometric properties reliability validity chinese version smoking behavioral questionnaire assess behavioral nicotine dependence among community dwelling adult smokers taiwan methods used survey design administration validation total adult smokers completed survey assess behavioral dependence nicotine dependence depression social support demographic smoking characteristics data analysis included descriptive statistics internal consistency reliability test exploratory factor analysis independent test pearson product moment correlation results showed good internal consistency reliability stability week test retest reliability extracted one factor explained variance indicating construct validity scale acceptable concurrent validity significant positive correlation nicotine dependence depression time smoking negative correlation age exercise habit instrument discriminant validity supported significant differences high low moderate nicotine dependence smokers greater years old years old younger smoked years less smoking years item satisfactory psychometric properties applied sample taiwanese adult smokers scale feasible valid use assess smoking behavioral dependence
thermoelectric generators niche candidate field energy management electrical generator devices generally comprehensive accurate design techniques thermoelectric generators reduced current approach complex time consuming processes study develops simple comprehensive accurate designing technique based proposed method predict efficient architecture accuracy comparing wide range possible temperature present applications moreover proposed method predicts electrical outputs high accuracies electrical current accuracy thermoelectric potential difference accuracy power output accuracy engineering approach save significant amount time reduce complexity design process moreover technique easily used without broad knowledge design elsevier ltd rights reserved
land plant contain two copies large inverted repeat promote high frequency homologous recombination generate genomic forms among canonical highly reduced completely lost however lineages acquired short novel also exhibit activity generate genomic structural diversity diversity shown exist occasionally within species known whether multiple genomic forms coexist within individual plants examine potential novel within individuals species sequenced four closely related species four identical gene content genome organization except large inversion approximately containing southern blotting showed different versions among individual whereas polymerase chain reaction high throughput read pair mapping revealed presence alternative form within individual plant furthermore comparative genomic studies demonstrate predominant arrangements changed several times results provide compelling evidence shifting forms evolution suggest shifting activity genomes adaptive
infinity norm relates maximum frequency response function infinity control method focuses case vibration excited fundamental frequency norm relates output energy systems input pulses white noises norm control method overall vibration performance systems trade performance frequency domain time domain achieved integrating two indices mixed vibration control method based linear fractional state space representation modal space piezoelectric flexible structure uncertain modal parameters modeled residual high frequency modes mixed dynamic output feedback control design method proposed suppress structural vibration using linear matrix inequality technique initial populations generated designing robust control laws different infinity performance indices robust norm performance index closed loop system included fitness function optimization flexible beam structure piezoelectric sensor piezoelectric actuator used subject numerical studies compared velocity feedback control method numerical simulation results show effectiveness proposed method
effectiveness situ remediation treat contaminated limited degree contact injected treatment chemical groundwater contaminant study candidate designs actively spread treatment chemical contaminant generated using multi objective evolutionary algorithm design parameters pertaining amount treatment chemical duration rate injection optimized according objectives established remediation maximizing contaminant degradation minimizing energy material requirements groundwater contaminants different reaction properties influence ability degraded situ remediation optimization conducted six different combinations reaction rate coefficients rates constants represent remediation common groundwater contaminants using treatment chemical results indicate active spreading contaminants low reaction rate coefficients conducted using greater amounts treatment chemical mass longer injection durations relative contaminants high reaction rate coefficients contaminants slow contaminants heterogeneous two different design strategies acceptable one high concentrations treatment chemical mass short duration one lower concentrations treatment chemical mass long duration thus decision makers select strategy according preference material energy use finally scenarios high ambient groundwater velocities injection rate used active spreading high enough groundwater divide encompass entire contaminant elsevier rights reserved
substantial harm result concurrent cigarette cigarette use dual use undermine smoking cessation perceptions chemical exposure resulting influence dual use conducted probability based phone survey adult cigarette smokers analyzed results subjects experiment smokers heard hypothetical scenario cigarettes cigarettes amount harmful chemicals cigarettes chemicals cigarettes chemicals present cigarettes smokers indicated scenario change interest dual use perceived health smokers heard products amount chemicals interested initiating increasing dual use however smokers interested cigarettes chemicals cigarettes chemicals cigarettes chemicals present cigarettes individuals cigarettes chemicals likely amount scenario perceive cigarettes harmful cigarettes harm perceptions partially explained relationship chemical scenario dual use interest smokers associated higher chemical amounts cigarettes versus cigarettes greater health cigarettes thus expressed increased interest dual use findings suggest amounts chemicals cigarette smoke cigarette encourage dual use elsevier inc rights reserved
projection computer graphics images walls architecture known projection mapping used widely applied many fields projection mapping relative alignment projected images target important efficiency projection mapping reduced due however process alignment manual time consuming solve problem propose automatic alignment method uses depth information geometrical characteristics plane method enables correction distorted image projected arbitrary angle result distortion reduced applying proposed method evaluated error rate defined performing additional experiments evaluating effect method part future works
road traffic noise widely studied environmental risk factor heart disease myocardial infarction particular given myocardial infarction leading disability mortality cause significant proportion urban population exposed high noise levels quantification burden disease attributable traffic noise essential environmental health policy making noise control engineering study aimed estimating burden myocardial infarction cases attributable road traffic noise urban population used methodology estimating burden disease attributable environmental noise outlined world health organization risk data extracted recently published meta analysis providing updated relationship traffic noise risk myocardial infarction based data calculated fraction myocardial infarction cases attributable traffic noise loss quality adjusted life years economic burden assuming sic per myocardial infarction cases attributed road traffic noise fifty five fatal nine hundred sixty eight lost cases monetary value sic million although measures used study crude give approximation real burden disease road traffic noise indicative important social economic aspect noise pollution results direct attention environmental health pivotal environmental issue
proteins signal variety locations addition canonical function cytoplasmic surface plasma membrane activated cell surface protein coupled receptors focus signaling activates signaling cascade ultimately resulting vesicle trans network develop novel molecular tool inhibiting endogenous spatial temporal manner take advantage lipid association mutant widely used inhibitor system show inhibit function expressed cells recruitment specific membrane location ability inhibit signaling recruited inhibits acid induced phosphorylation akt whereas recruited inhibits transport moreover show recruited inhibits model targeted targeted delivery secretory providing first evidence selectivity terms transport regulated last show fragmentation induced blocked inhibition demonstrating key regulator multiple pathways impact morphology thus developed new molecular tool modulate signaling specific subcellular locations demonstrate novel selectivity regulation transport novel role mediating fragmentation
known severe potential adverse drug reaction therapy report case due drug drug interaction review literature case year old woman received without problem years intravenous added treating fungal infection developed weeks later removal led resolution new case demonstrates subjects even moderate inhibitor lead subjects receiving characteristics reported cases associated drug interaction
linear time invariant framework transformation input output equation state space representation understood several canonical forms exist dynamic behaviour coefficients become time varying however transformation longer holds prove induction exists closed form expression observability canonical state space model using binomial coefficients
therapeutic supportive care interventions become increasingly effective growing numbers childhood adolescent cancer survivors face myriad physical psychological sequelae secondary disease treatment mental health issues particular present significant problem unique patient population depression affecting number childhood adolescent cancer survivors multiple key determinants impact survivors risk developing depression variables across biologic individual family community global levels spanning throughout life course human development prenatal periods adulthood multi level life course conceptual model offers valuable framework identify organize diverse variables modulate risk developing depression survivors childhood adolescent cancer review describes first multi level life course perspective applied development depression childhood adolescent cancer survivors conceptual framework used guide investigation mental health interventions ensure key determinants depression occurrence adequately addressed across various levels throughout life trajectory
modular modular two fundamental operations various cryptographic applications hence performance public key cryptographic algorithms strongly influenced efficient implementation operations reducing frequency modular time requirements modular multiplication help developing efficient modular exponential algorithms work proposes energy efficient modular exponential algorithm based bit techniques particular two algorithms bit bit bit bits modifications existing binary exponential algorithm developed hardware proposed algorithms evaluated terms throughput power energy results show increased throughput order reduction power energy saving order algorithms respectively evaluation board simulation synthesis tool used hardware realization fpga synthesized using cadence asic elsevier rights reserved
study effect acid treatment plants head development quality parameters weight loss color respiration rate antioxidant activity measured hplc harvest storage days degrees evaluated treatment increased percentage first class although significant effect found developmental process treatment reduced respiration rate led higher total antioxidant activity total concentration harvest cold storage addition identified first time thus concluded treatment natural useful tool delay senescence improve reported health beneficial properties consumption elsevier ltd rights reserved
objective growing number patients require procedure due inadequate weight loss primary bariatric surgery psychological factors eating disorder frequently responsible poor weight loss results primary surgery aim study determine whether preoperative psychological factors personality disorders eating behaviors surgery candidates differ primary bariatric surgery candidates methods november june candidates bariatric surgery extensive psychological assessment included study patients evaluated using different assess psychological factors item short beck depression inventory hospital anxiety depression scale perceived stress scale schedule self esteem scale eating behaviors test food addiction scale scid data compared groups primary procedures results eighty nine subjects candidates primary bariatric surgery subjects procedure due insufficient weight loss preoperative psychological factors also eating behaviors differ significantly primary surgery candidates borderline personality disorder appeared twice frequent surgery candidates respectively discussion unexpectedly found eating habits make difference looking disorders especially impulsivity personality traits seems relevant appears special trait candidates procedure compromise weight loss
number studies reported dysfunctions steroid secretion including altered cortisol testosterone levels borderline personality disorder patients compared healthy controls present study extends findings blood saliva studies cumulative measure hair steroids investigated women bpd age education matched healthy women find differences bpd patients healthy women concerning hair cortisol levels increased hair testosterone levels among bpd patients compared controls results remained restricting analyses patients data indicate altered long term testosterone cortisol levels females bpd future studies address possible impact altered testosterone medical illness processes including metabolic syndrome population elsevier ltd rights reserved
purpose evaluate impact adjuvant radioactive iodine therapy prognosis assessed progression free survival overall survival patients affected differentiated thyroid carcinoma lymph node relapse previously treated retrospectively evaluated patients treated lymph node dissection disease relapse patients previously undergone total ablation used clinical histological data obtained follow assess response outcome means univariate multivariate time event analyses assessed impact outcome prognostic role levels suppression levothyroxine measured months risk factors evaluated patients age diagnosis median years interquartile range treated median follow time years patients showed disease progression died kaplan meier curves showed age diagnosis tumor histology tumor size aggressive variant associated prognosis patients treated showed better log rank untreated patients effect observed patients multivariate models showed age yes remained independent factors associated age remained significantly associated nonetheless patients treated showed lower risk mortality untreated patients relapse significantly associated better patients
using continuous flash suppression demonstrated four experiments affective information extracted faces influences affective personality judgments neutral faces four experiments participants judged neutral faces studies less trustworthy attractive study less competent warm study paired faces compared paired neutral faces findings suggest affective influences normal part everyday experience provide evidence affective foundations consciousness affective arises even affective changes occur neutral stimulus presented demonstrating affective influences explained simple semantic priming effect findings implications understanding constructive nature experience role affect social impressions
objectives investigate association physical fitness obesity health related quality life hrqol sleep disturbance community dwelling older spanish women years age study design cross sectional study method sleep disturbance assessed sleep scale active sedentary behaviors recorded standardized questionnaires hrqol assessed anthropometric measurements obtained using standardized techniques body fat measured using impedance physical fitness evaluated set eight tests results sleep disturbance reported women associated higher body mass index waist circumference presence insomnia inversely associated physical fitness women upper fitness index lower risk sleep disturbance compared lower women highest upper body strength lower risk sleep disturbance compared lower women without sleep disturbance showed better hrqol conclusion sleep disturbance associated central obesity lower physical fitness reduced hrqol interventions involving weight management improvement physical fitness contribute better sleep quality older women
human activity recognition key task ambient intelligence applications achieve proper ambient assisted living remarkable progress domain challenges still remain obtain robust methods goal work provide system allows modeling recognition set complex activities real life scenarios involving interaction environment proposed framework hybrid model comprises two main modules low level sub activity based data driven methods high level activity implemented fuzzy ontology include semantic interpretation actions performed users fuzzy ontology fed sub activities recognized low level data driven component provides fuzzy reasoning recognize activities influence environment semantics additional benefit approach ability handle uncertainty knowledge based module substantially outperforms treatment incomplete data respect classic ontologies validate advantages public cad dataset activity dataset achieving accuracy low level high level activities respectively entails improvement fully data driven ontology based approaches
multiple avenues research criminal careers intergenerational family transmission epidemiological studies indicated concentration antisocial traits behaviors cluster among families within individuals population current study draws perspectives exploring intergenerational antisocial personality disorder across multiple generations large scale epidemiological sample analytic sample persons meeting criteria antisocial personality disorder derived waves national epidemiologic survey alcohol related conditions path analytic latent class multinomial models executed describe elucidate family histories among persons diagnosed antisocial personality disorder three classes antisocial family tree found minimal family history problem behaviors sample characterized higher socioeconomic functioning parental progeny behavior problems sample characterized criminal behaviors psychopathology substance use disorders history problem behaviors sample characterized psychopathology versatile criminal offending findings add typology intergenerational studies antisocial behavior assist identifying etiological treatment factors among crime runs family
online consultation increasingly offered parenting practitioners clear feasible provide empowerment oriented support single session consultation based empowerment theory developed guiding empowerment process model model evaluate text based consultation content analysis advice total investigated feasibility newly developed model inter observer agreement internal consistency factor structure validity concurrent validity evaluated comparing coding results using model social support model partially empowerment results showed good inter observer reliability internal consistency model results provided evidence concurrent validity significant correlation coding results model social support model although also distinctive described techniques practitioners employ guide parental process towards empowerment observed sample also guidance provided components empowerment process feasibility model content analysis consultation parental support theoretical empowerment perspective demonstrated
purpose colorectal cancer crc fifth common cause cancer deaths china fourth worldwide metastatic dissemination primary tumors considered main cause crc related mortality serine threonine kinase gene novel cancer testis antigen found significantly highly expressed gastrointestinal cancers study aimed analyze correlation expression patterns tumor stage grade crc patients results relative expression level significantly higher patients lymph node metastasis expression levels primary tissues metastatic patients significantly higher lymph nodes samples rna level protein level materials methods surgical specimens cancerous tissues paired adjacent tissues lymph nodes crc cases different clinicopathological features collected expression detected measured immunohistochemistry quantitative real time polymerase chain reaction qrt pcr conclusions data suggest potential biomarker detecting monitoring predicting metastatic risk colorectal cancer
statistical analysis massive complex data sets require development algorithms depend distributed computing collaborative inference inspired propose collaborative framework aims estimate unknown mean theta random variable model present certain number calculation units distributed across communication network represented graph participate estimation theta sequentially receiving independent data messages via stochastic matrix defined graph give precise conditions matrix statistical precision individual units comparable gold standard virtual centralized estimate even though unit access data show particular fundamental role played non trivial eigenvalues class graphs provide remarkable performance moderate algorithmic cost
rationale maintenance surface immune barrier important homeostasis organs mucosal surfaces interface external environment however role mucosal immune system chronic lung diseases incompletely understood objectives examined relationship secretory iga mucosal surface small airways parameters inflammation airway wall remodeling chronic obstructive pulmonary disease copd methods studied small airways diameter former smokers copd control subjects small airways identified serial tissue sections examined epithelial morphology bacterial dna nuclear factor kappa activation neutrophil macrophage infiltration airway wall thickness measurements main results morphometric evaluation small airways revealed increased mean airway wall thickness inflammatory cell counts lungs patients copd compared control subjects whereas level mucosal surface decreased however small airways classified intact deficient found pathologic changes localized almost exclusively deficient airways regardless study group deficient airways characterized abnormal epithelial morphology invasion bacteria across apical epithelial barrier nuclear factor kappa activation accumulation macrophages neutrophils fibrotic remodeling airway wall conclusions findings support concept localized acquired deficiency individual small airways patients copd allows bacteria cross epithelial barrier drive persistent inflammation airway wall remodeling even smoking cessation
circulating endothelial progenitor cells bone marrow derived stem cells able migrate sites damaged endothelium differentiate endothelial cells altered level function described various inflammatory diseases shown augment murine models previous studies context crohns disease yielded conflicting results determine whether circulating levels changed context patients healthy controls recruited disease activity assessed peripheral blood mononuclear cells isolated numbers evaluated analysis using anti anti vegf receptor anti anti markers eighty three subjects including patients controls recruited including males aged years cases controls respectively mean disease duration years receiving biologics mean duration months mean level peripheral patients percent controls significant correlation levels age disease duration duration treatment biologics elevated patients studies needed examine function possible role marker disease severity therapeutic response
spite modern treatment acute myocardial infarction ami still carries significant morbidity mortality worldwide even though standard care therapy proves symptoms also long term prognosis patients ami solve critical issue specifically permanent damage cardiomyocytes result complex process occurs namely cardiac remodeling leads alterations cardiac size shape function driven quest therapeutic strategies aiming injured cardiac vascular tissue one latest regard stem cell therapy based favorable data obtained experimental studies therapeutic effectiveness innovative therapy investigated clinical settings various cell types used clinic autologous bone marrow derived first used treat ami patient years ago since witnessed increasing body data regards cutting edge therapy although feasibility safety transplant clearly proved efficacy still conducted studies meta analysis reported conflicting results hope conclusive answer provided largest ongoing trial designed demonstrate whether treatment lives strategies enhance regenerative potential applied suggested position papers recommendations published learned far properly use knowledge gained review analytically discuss topics summarizing current state knowledge field
pseudomonas aeruginosa opportunistic gram negative pathogen different tissues utilization diverse mechanisms one involve breakdown host cell membrane sequential action phospholipase phosphatase action phospholipase produces inorganic phosphate available biochemical data enzyme demonstrate involvement two binding sites catalytic cycle enzyme regulation crystal structure aeruginosa determined folds three structural domains first domain residues involved catalysis conserved among superfamily proteins second domain characteristic involved recognition moiety substrate third domain relative position two crystal structure captures molecules bis amino active site additional site represents two relevant complexes just one two inhibitory molecules provides basis function regulation site directed mutagenesis along biochemical experiments structural observations demonstrates interplay different sites recognition inhibition structural comparison family provides three dimensional picture conserved catalytic cycle structural basis recognition diverse substrate molecules elsevier ltd rights reserved
background study aimed determine frequency infection school children community order understand dynamics infection within school family spheres population public health problem endemic disease mexico incidence rate varies depending state affected states show highest numbers new cases per year previously reported molecular frequency infection rural communities state methods children schools studied estimate frequency intestinal parasites microscopic examination fresh stool samples number studied individuals school children molecular characterization carried polymerase chain reaction pcr using species specific primers amplify short tandem repeats non coding sequences associated gene amplified fragments sequenced analyzed results eight different genotypes obtained isolates molecular marker none cases species detected developed symptoms attributable invasive process disease moreover condition appeared significant impact development nutritional status affected children genotype corresponds reference strain considered non pathogenic prevalent conclusions comparison genotypes species show correlation children relatives community species genotype widespread based indicators growth development nutrition status studied community seems reasonably adapted constant exposure intestinal parasites since evidences serious impact condition childrens health
analog filters key blocks analog signal processing widely employed many systems like wireless detectors read sensors interfaces etc technology choice systems mainly requirements high speed low power consumption digital circuits impressive movement towards scaled technology important consequences analog circuits design impact technology scaling scale analog filters design investigated instance supply voltage reduction analog filters limits circuits design solutions result higher power consumption moreover time innovative systems push analog filters get higher higher operation frequencies due increasing bandwidth speed requirements recent solutions efficient low voltage high frequency analog filters technology described
objective successful program serious mental illness responsive families modified hepatitis virus hcv effectiveness study carried comparing hcv didactic education patients methods sample adult hcv patients recruited three outpatient settings randomized hcv didactic control groups met min months following separate structured protocols hcv sessions included didactic curriculum developed uniquely groups member choice group problem solving support interactions patients assessed baseline intervention year later demographic hcv related variables structured diagnostic interview data obtained results groups improved significantly major depression alcohol drug use quality life risk behaviors treatment satisfaction worsened disability perceived hcv related problems intervention groups differ outcomes conclusion even though active intervention achieve significant improvement relative control condition observable improvements conditions warrant exploration contributions education support potentially important elements hcv behavioral intervention study needed identify elements common education interventions improved outcomes time copyright wolters kluwer health inc rights reserved
present study examined whether grade point university students predicted appearance based ratings undergraduate participants provided self reports big five personality traits copies student transcripts obtained photographs undergraduates taken personality traits judged perceivers aggregated single ratings predicted aggregated ratings predicted self ratings suggesting appearance based contain trait relevant information beyond scope self reports results contribute growing literature documenting validity appearance based personality traits
social pain often associated social rejection shares neural correlates aspect physical pain also indicate overlap function pain described motivational signal respond source pain adaptive way altering behavior tested whether social pain causes similarly adaptive alterations behavior participants played computerized ball tasks putative players one passed one excluded participant play social version assessed behavioral consequences social pain comparing number stimulus social course task questionnaires assessed subjective feelings social pain decrease stimulus observed social version indicating rejection social nature leads change behavior moreover participants reported negative feelings toward stimulus social version subjective feelings social pain mediated effect version game social changes behavior indicating social pain social rejection causes changes behavior
found several plant species worldwide causes severe livestock plants leading chronic condition characterized weight loss altered behavior depression decreased infertility death detected north american species eight belong taxa four taxonomic sections sections belong two larger groups representing several morphologically related species pacific small objective study screen species sections previously known contain furthermore broaden scope species within sections pacific small screened detected first time taxa representing species using liquid gas chromatography coupled mass spectrometry several taxonomic sections highly enriched species contain others systematic examination species provide important information toxic risk species valuable reference land managers
personality profiles describe individual persons locations multiple trait dimensions enable calculation profile similarity indices individual persons dyads easily however unless two components distinguished normative component comprising sample means variables distinctive component reflecting given individuals deviations means two profile components provide different kinds information focusing person perception research review predictors similarity individual profiles normative profile profile agreement distinctive profiles also provide suggestions future research
live attenuated malaria vaccine vaccine vaccine confers sterile protection controlled human malaria infection parasites homologous vaccine strain final vaccination malaria vaccine demonstrated long term protection using parasites vaccine strain conducted open label trial vaccine dose administered three times intervals malaria naive adults homologous parasites final immunization nine volunteers remained without compared none six controls nine subjects six underwent repeat parasites final immunization five six remained without compared none six controls specific cell antibody responses detected vaccine recipients cytokine production cells subjects vitro stimulation homologous highly correlated interestingly specific cell responses blood peaked first immunization enhanced subsequent collectively data suggest durable protection homologous parasites achieved vaccine ongoing studies determine whether protective efficacy enhanced additional alterations vaccine dose number
introduction relatively rare debilitating condition pose significant treatment covered manuscript discuss etiology classification manifestations evaluation summarize different surgical techniques evaluate success rates perioperative considerations according cited commentary deep understanding disease treatment options familiarity different surgical treatment options available mandatory choosing correct treatment surgical treatment tailored specific patient many patients eventually successful resolution review address management patient outcomes treatment
deficiency visually debilitating condition caused abnormal maintenance treated transplantation donor derived epithelial cells success depends presence quality transplant understanding responses cells within improve cell survival however human corneal rings used source always readily available research purposes alternative hypothesized human corneal epithelial cell line used model studying constitutively expressed human leukocyte antigen hla class class molecules however stimulated interferon gamma expressed hla class antigens also migratory response expressed stem cell markers addition contain side population cells enriched population used cells show cells non side population cells also expressed cells expressed higher levels capable colony formation colonies smaller contained fewer cells addition expressed delta alpha results suggest useful model understanding using vitro approach without reliance supply human tissue
analytical calculation magnetic forces currently interesting alternative time consuming finite element method due high accuracy low computational cost paper new semi analytical solution determining force magnetic guidance significant role controlling developing high precision magnetic positioning system presented important result new expression compared known equations literature considers position dependence magnetic force whole travel range order derive force magnetic field permanent magnet first calculated introducing solving magnetic scalar potential taking lorentz force law consideration proposed equation finally derived semi analytical equation suitable designing optimizing magnetic guidance furthermore also used developing actuators calculated force derived equation verification measurements likewise presented paper
state games sport athletic event takes place days july august new counties course years average athletes year year sports medical coverage state games coordinated article reviews medical contacts involved four games art average total medical contacts produced injury incidence rate injuries minor sprains strains injuries occurred lower extremities treated adequately ice compression adhesive basic first aid supplies incidence injury higher contact sports soccer reported injuries per participant coverage events requires basic first aid treatment soft tissue injuries emphasis lower extremity injuries
structure damage identification long span bridge conducted three dimensional dynamic displacement data collected gps subsystem health monitoring system suspension bridge first effects temperature main girder spatial position coordinates analyzed transverse longitudinal vertical directions bridge correlation regression models built temperature position coordinates main girder longitudinal vertical directions indices coordinate conducted mean value control chart applied making statistical pattern identification abnormal changes girder dynamic coordinates finally structural damage method main girder established analysis results show temperature remarkable correlation position coordinates longitudinal vertical directions bridge weak correlation transverse coordinates abnormal change longitudinal coordinates abnormal change vertical ones caused structural damage respectively identified mean value control chart method based gps dynamic monitoring data hence structural abnormalities state identification damage main girder long span suspension bridge realized multiple directions
data communication network changed way business daily works now rely computer network computer network channel share data also called data network security data transmission one important aspects considered modern communication system paper data transferred sent certain pattern embedded huge amount data seen effectiveness proposed method described way increase security data data binary image key needed rather algorithm based binary tree bits plotted significant bit least significant bit middle bit proposed algorithm data security
purpose purpose study investigate extent sweden recommend use nutritional supplements changes diet smoking cessation patients risk signs age related degeneration addition study also examined practitioners rate strength evidence nutritional supplements management sources information determine supplement recommendations prevention treatment methods study implemented cross sectional design using data questionnaire swedish registered membership databases respective professional organizations invited participate questionnaire contained forced choice questions one free text question organized following four sections use nutritional supplements dietary advice smoking eye diseases strength evidence sources information regarding nutritional supplement interventions results response rate likely recommend nutritional supplements provided significantly advice diet patients risk established disease likely rely findings age related eye disease studies regarding treatment selection supplements recommend smoking cessation conclusion common evidence based strategies management among eye care professionals presumably beneficial patients targeted education implementation strategies needed
acyl carrier protein sad key enzyme determines ratio saturated unsaturated fatty acids higher plants using reverse transcriptase polymerase chain reaction rapid amplification cdna ends full length cdna sad obtained developing leaves sequence analysis showed deduced amino acid sequence high similarity reported gene functionally expressed escherichia coli activity recombinant protein markedly detected assayed vitro adding southern blot analysis indicated gene member small gene family northern blotting revealed gene highly expressed developing leaves results provide opportunities modifying fatty acid composition
paper proposes probabilistic optimization method produces optimal curves submitted day ahead electricity market market considering flexible demand customers based time dependent resources batteries demand taking account possible imbalance costs uncertainty forecasts market prices demand renewable energy sources res generation optimization strategy aims minimize total cost energy whole day taking account constraints proposed formulation leads solution different linear optimization problems following natural temporal sequence electricity spot markets constraints regarding time dependent resources fulfilled scheduling process performed day ahead market different problems moderate dimension requires short computation times benefits proposed strategy assessed comparing done sample period one year following different deterministic probabilistic strategies results show probabilistic strategy reports better benefits participating power markets
article argues news coverage plays important role national identity building way evaluates nation better foreign nations group group bias notion transferred media element national cultural identity article identifies national identity building mass media third person perception states people assume others vulnerable negative media influences hypothesized patterns international third person perception occur news coverage news media present media influences country weaker countries first standardized content analysis coverage germany countries supports hypothesis consequences discussed directions future research pointed
book arguably marks beginning termed late style period output characterised shift towards monolithic blocks text featuring highly disrupted syntax vocabulary drawn range increasingly technical specialist fields paper considers whether high writing requires similarly high approach reading describing efforts interpret using custom built computer program linked google books database particular examines theoretical implications machine reading light existing interpretations focusing peculiar aesthetic implications exponential technological development text even acts dissection complex incorporation sources ranging mother computer programming attempt computational processing leaving text paradoxically immune deformed technological progress
paper uses fuzzy neural network modelling identification structural parameters multi shear buildings first identification done using response structure subject ambient vibration fuzzy initial condition forced vibration horizontal displacement form used investigate identification procedure model developed handle data form multi shear structure procedure tested identification stiffness parameters simple example problems using prior values design parameters
aim study cross compare patient reported knee function outcomes people chose non surgical treatment acl injury chose acl reconstruction extracted knee injury osteoarthritis outcome score data entered swedish national acl registry patients non surgically treated acl injury within injury injury data compared cross data collected pre post age gender matched groups patients primary acl reconstruction comparisons patients chose surgical treatment reported superior quality life function sports mean difference points respectively mean difference points respectively compared chose non surgical treatment patients chose acl reconstruction reported superior outcomes knee symptoms function knee specific health related quality life compared patients chose non surgical treatment
pathophysiological concepts primary headache diseases developed significantly last decades nevertheless pathophysiology single diseases unexplained migraine headache arises activation trigeminal essential processes located vessels peptide seems essential importance concerning migraine cluster headache mechanisms leading peripheral central sensitization relevant migraine tension type headache higher level centre hypothalamus seems essential meaning initiation migraine attacks sympathetic parasympathetic neural system causes cranial autonomic symptoms headache diseases affected therapeutically
interferon beta preparations commonly used first line therapy relapsing remitting multiple sclerosis however characterized limited efficacy partly due formation anti antibodies patients pilot study assessed elisa method presence binding antibodies interferon beta years therapy subcutaneous interferon beta patients antibody levels established within year treatment withdrawal used commercially available therapy namely limited antigens found patients depending units expression levels anti antibodies remained high patients patients dropped significantly strong correlations obtained assays anti anti anti anti anti anti existence cross reactivity formation antibodies tested formulations interferon beta confirmed levels remain significant clinical context assessment first choice screening however methods evaluation crucial decisions studies needed confirm results specifically interest evaluate methods neutralizing antibodies identification assessed binding antibodies nevertheless results support concept interferon positive binding antibodies switching therapy alternative disease modifying agent example acetate justified whereas switch another interferon formulation probably benefit
advent smart materials given new dimension field materials science resulting many significant application oriented developments fields engineering piezoelectric material important member smart material family bulk sensors actuators used widely smart structure applications limitation using material bulk form sensors actuators real applications due high temperature processing small area coverage associated effects using adhesive bond layer situ transducers covering large area provide good solution aforementioned problems indigenous development smart conformal coating low process temperature makes suitable silicon batch processing fabrication mems also evaluation metals composites guided wave based real time structural health monitoring shm chapter presents development application specific situ coating technical challenges
lipoprotein lipase identified anti hepatitis virus hcv host factor cellular mechanism remains elusive investigated cellular mechanism involving anti hcv functional activation activated receptor ppar alpha signal hepatocytes investigated hcv infected cells primary human hepatocytes hcv core transgenic mice result showed levels transcriptional nuclear translocation ppar alpha cells primary human hepatocytes elevated physiologically ranged treatment either low density lipoprotein hcv particles induced hepatic ppar alpha activation weakened blocking enzymatic activity preventing cellular uptake free unsaturated fatty acids either albumin silencing ppar alpha reversed mediated suppression hcv infection furthermore treatment like direct activation ppar alpha reduced levels involved assembly release hcv also alleviated hepatic lipid accumulation induced core protein hcv core transgenic mice exhibited hepatic mir negatively regulates ppar alpha expression wild type controls induction activity fasting core transgenic mice activated ppar alpha downstream target genes involved fatty acid beta oxidation taken together study reveals dual beneficial outcomes anti hcv anti light control chronic hepatitis relation modulators
wild plant native iran traditionally used iranian medicine mild tea reducing anxiety treatment gastrointestinal disorders previous study ethyl acetate extract proved anti activity present study designed determine chemical components biologically active fraction extract prepared using method column chromatography medium pressure liquid chromatography used respectively separate fractions finally evaluated fractions used high pressure liquid hplc peak technique achieve purification separated compounds determined using nmr analysis mass spectroscopy six compounds isolated extract aerial parts including four flavonoids
primary effector cells mediate matrix remodeling pulmonary fibrosis rapidly assemble extracellular matrix key component specialized cellular bind extracellular hypothesized play role modulating mediated matrix formation found expression increased foci lungs idiopathic pulmonary fibrosis transforming growth factor tgf beta profoundly regulates expression kinetics parallel expression marker smooth muscle actin tgf beta induced expression dependent signaling tgf beta receptor rho kinase actin leukemia serum response factor dependent small interfering rna mediated knockdown disrupted tgf beta induced differentiation without affecting tgf beta signaling contrast loss resulted disruption focal adhesion kinase phosphorylation focal adhesion formation actin stress fiber development finally essential formation assembly collagen matrix summary data show novel dependent gene induced pulmonary fibrosis plays essential role tgf beta induced differentiation mediated formation extracellular collagen matrix targeted disruption associated signaling provide avenue inhibit tissue fibrosis
background project initiated quasi experimental study based active outreach suicide preventive intervention inspired norwegian model year follow study conducted randomized controlled trial showing kind active outreach suicide significant preventive effect prevalence suicide attempts significantly reduced number patients suicide year rct follow aim investigate sustainability suicide preventive effect shown year follow one hundred thirty three suicide included year follow rct study university hospital randomized rapid outreach suicide preventive intervention offering intervention patients suicide attempt significant preventive effect total suicide attempts significantly reduces number patients suicide attempt suicide preventive effect weeks years effect number patients suicide attempt longer sustainable effect number repetitive events remains study emphasizes importance rapid active outreach intervention points effect number patients suicide attempt longer sustainable years suggesting need follow intervention
sustainable green building practices adopted higher education institutions new campus buildings major daily operations paper provides synthesis opinions existing practices related water conservation institutional green buildings member institutions association physical plant administrators specific focus regarding operation attempted web based survey follow one one interviews utilized extract information data industry professionals survey evaluated institutions use policy related sustainable building practices focused approaches water conservation regional preferences provided barriers water conservation practices approaches identified operational challenges evident particularly relate clear higher education institutions engaging water conservation practices across canada united states work contributes foundation future research analysis related best management practices water conservation higher education sector
review summarizes present evidence role diagnosis prognosis cause cardiovascular alcoholic liver disease question whether merely marker causal factor development cardiovascular liver disease addressed emphasis randomization design randomization approach uses genetic variants associated lifelong high plasma levels largely prone reverse thus approach mimics controlled double blind randomized trial uses genetic variants rather drug placebo like blinded trial allows inference causality moreover review also covers background molecular biology functions levels healthy individuals reference range role biomarker cardiovascular alcoholic liver disease plasma protein named three terminal amino acids tyrosine lysine leucine molecular weight produced local inflammatory cells inflamed tissues lipid macrophages inside vessel wall perhaps also hepatic cells observational studies show plasma levels elevated patients cardiovascular liver disease associated disease severity prognosis furthermore elevated plasma levels apparently healthy individuals associated fold increased risk future ischemic stroke venous thromboembolism myocardial infarction suggesting play role formation rather atherosclerosis per elevated levels combined excessive alcohol consumption associated years risk alcoholic liver cirrhosis suggesting used strong noninvasive marker predicting alcoholic liver cirrhosis importantly randomization studies genetically elevated plasma levels associated risk cardiovascular alcoholic liver disease thus suggesting plasma play causal role development diseases despite plasma levels play role disease progression diagnosis inhibition activity novel therapy cardiovascular liver diseases
single definition use medications commonly used alternative quantitative definition use medications clinically indicated use unnecessary harmful prescribing proposed protocols algorithms improve prescribing older adults developed american society criteria screening tool older peoples prescriptions explicit criteria reflect elements common across protocols algorithms concepts incorporated reduction strategies improve outcomes care older adults
psoriatic patients systemic inflammation oxidative stress associated cardiovascular disorders atherosclerosis hypertension myocardial infarction stroke psoriasis also shown associated kidney disease several studies disorders also strong component oxidative stress usually nadph inducible nitric oxide synthase inos however whether psoriatic inflammation leads renal oxidative stress dysfunction remains unexplored therefore study investigated effect induced psoriatic inflammation kidney function inflammation murine model mice applied followed various analyses kidney blood related inflammation kidney function psoriatic inflammation mice associated kidney dysfunction reflected increased serum creatinine blood urea nitrogen kidney dysfunction upregulation ros generating enzymes inos concomitant oxidative stress treatment either general antioxidant acetyl cysteine nox inos inhibitors led improvement induced renal dysfunction oxidative stress contrary oxidant inducer induced renal impairment oxidant antioxidant imbalance data suggest psoriatic inflammation causes kidney dysfunction inos play important roles treatment antioxidants considered adjunct therapy psoriatic patients kidney disease elsevier rights reserved
growing clinical evidence support diet irritable bowel syndrome ibs low low diet gaining acceptance globally among clinicians ibs alike however disparity concerning success rates diet patients attributed differences recommended diet adherence issues address differences diet generally accepted science based definition analytical criteria low products suitable low diet developed address adherence challenge regulators permit manufacturers low products communicate benefits low diet product labels material facilitate people ibs selection use low foods
background vitamin possibly vitamin established association fracture risk vitamins however less studied aim determine whether specific vitamin play role risk hip fracture bone turnover methods case control study blood drawn measurements vitamins acid bone turnover markers osteocalcin bone specific alkaline phosphatase upon admission hip fracture patients home dwelling non controls results vitamin populations reported previously results low vitamin concentrations independently associated risk hip fracture adjusted odds ratio confidence interval per increase vitamin concentration vitamin respectively results principally unchanged vitamin body mass index potential confounders adjusted vitamins except acid correlated positively total osteocalcin negatively bone specific alkaline phosphatase conclusions low vitamin concentrations associated increased risk hip fracture possibly mediated bone turnover mechanisms elsevier ltd european society clinical nutrition metabolism rights reserved
background study sought investigate external photon beam radiation catheter free ablation junction intact pigs methods results ten pigs randomized either sham irradiation irradiation junction animals underwent baseline electrophysiological evaluation cardiac gated multi row computed imaging beam delivery planning intensity modulated radiation therapy doses coronary arteries optimized invasive follow conducted months irradiation mean volume irradiated target dose mean follow length irradiation days irradiated animals complete block achieved animals dose groups using targeting margins ablation lesion size notably increased delivered dose volumetric effects lines around target volume mean calculated atrial lesion volume dose groups lesions extended short term side effects observed damage observed tissues nerves however histology revealed field beam effects outside target volume conclusions single fraction doses low caused lesion interruption cardiac impulse propagation using respective target volume doses maximal point doses coronary arteries kept target lesions fully achieved using approach
background dutch healthcare care providers order improve quality care recently assessed promoted use guideline smoking cessation counselling practices supervision programme consisted enforcement guideline site visits purpose qualitative study identify factors related guideline adherence supervision programme investigate whether programme helped improve adherence methods conducted semi structured interviews non additionally studied documents observed inspection process sampled work primary care practices providing care pregnant smokers questions included current provision smoking cessation counselling support counselling recent changes provision counselling reasons recent changes knowledge supervision programme experiences supervision results results show guideline adherence depends several factors awareness familiarity guideline important outcome expectancy additionally motivation guideline factors environment factors mentioned besides previously documented factors found professional collaboration also determined guideline adherence increased collaboration counselling associated greater adherence guideline provision counselling taking required training supervision programme helped improve stop smoking counselling making aware counselling giving extrinsic motivation provide counselling conclusion motivation environmental aspects important factors related guideline adherence professional environment added significant factor improved guideline adherence partly attributable supervision programme
provides strong isolation mechanism safety computing fields generation formally verified functional correctness provides desirable code base partitioning operating systems long way partitioning take first step focus temporal aspect implementing partitioned based however implements inside kernel conflicts genera principles standard temporal partitioning address problem propose user mode approach also elaborate performance
urgent effectively mitigate flood disasters humid areas southeastern china increasing flood risk urbanization study rural district area planning build industrial park covering area selected estimate potential rainwater extent runoff volume potentially mitigated rainwater harvesting addition optimum capacity rainwater harvesting system planned industrial park evaluated using daily water balance simulation cost efficiency analysis results showed rainwater harvesting planned industrial park great potential annually rainwater approximately optimum capacity determined optimum capacity annual rainwater usage rate showing neither financial savings deficits rainwater harvesting reduce runoff volume cases critical rainfall storm annual average maximum daily rainfall runoff volume case maximum daily rainfall respectively surface runoff collected stored rainfall amount less event
labeling childrens social play behavior important process childrens peer play analysis traditionally done experienced growing volume data automatic methods labeling increasingly required paper presents novel method classify childrens social play behavior peer play scenarios three categories solitary play parallel play group play based two key cues proximity proposed play observation scale features pairwise features calculated describe relationships child whole context interactions two children inspired recent studies social behavior analysis interaction recognition childrens activities classified support vector machine svm hidden conditional random field method evaluated dataset childrens peer play scenarios collected psychology researchers results show method good performance dataset
contribution analyses knowledge aberrations affecting non verbal communication children autistic spectrum disorder asd perspective speech language therapists working schools medical settings czech republic via questionnaire responding originally addressed perceive regarding disruption nonverbal communication frequent deficits detected relating semantic linguistic level morphological linguistic level research highlighted visible deficits associated mainly knowledge domain within asd authors published elsevier ltd
bridging factor transcriptional activator mediates transcriptional activation bridging sequence specific activator like proteins box binding protein studied arabidopsis thaliana saccharomyces cerevisiae drosophila understood fungi study report identification characterization rice blast fungus causes devastating rice blast disease ideal model studying growth development pathogenic mechanisms fungi encodes amino acid protein typical domain domain bioinformatics used analyze structural domains phylogenetic relationship different organisms generated deletion mutants delta functional transformants found deletion mutants showed significant defects growth tolerance exogenous stresses nacl moreover delta showed reduced pathogenicity smaller infection lesions wild type strain decreased response accumulation ros reactive oxygen species initial infection stage taken together data indicate required growth pathogenicity stress response
design machine elements course one difficult complicated courses mechanical engineering program requires concept generation knowledge geometrical design basic knowledge stress deformation analyses three elements machine elements design philosophy established developed course material chosen carefully since time allow cover design essential machine elements material covered lectures readings problems design projects addition content course contains five special elements idea generation safety considerations design day designers study three projects including final project shaft design idea generation project students generate idea machine mechanical device safety consideration project done inspection documentation unsafe elements campus shaft design project students design shaft system given students present existing advanced machines chosen using different sources industrial experience assignment addresses designers legal responsibility case defective product caused injury accident material taught course larger conventional machine element design course elements added beyond structural analysis bring better understanding engineering problems senior design course later engineering practice allow students connect theory real world engineering challenges gives students satisfaction learning process cognitive benefits engineering practice design approach teaching team course problem solving based many years instructors experience teaching engineering problem solving design learning pattern students work teams problem solving design exercises also helps conduct course thanks elements learning experience course unique engaging despite high level difficulty associated
purpose study understand young mothers retrospectively construct sexual reproductive health communication events sixteen depth qualitative interviews conducted mothers ages south central region usa findings indicate within population peer influence stereotypes medical encounters formal health education experienced within culture exhibits tension adolescent sexuality theoretical applied implications role cultural values including traditional gender roles understanding social construction young peoples sexuality region practical implications sexual education nature communication healthcare setting applied current education curricula medical communication practices suggest future programmes effective adapted specific culture within taught
sorting one important algorithms computer programming ordinary sorting algorithms analyzed compare algorithmic time complexity stability executive efficiency sorting algorithms verified java program time stability sorting algorithms compared provide certain reference sorting algorithm
monitoring analyzing floor vibrations determine human activity major applications fields health care security example structural vibrations used determine elderly person living independently falls room occupied empty monitoring human activity using floor vibration promises advantages methods example privacy concerns methods vision based techniques compliance challenges wearable sensors analysis signals becomes classification problem determining type human activity unfortunately research groups performing research subject even though significant number techniques applied field date systematic study challenges advantages using different types algorithms problem performed paper proposes benchmark problem encourage researchers design new algorithms monitoring human activity using floor vibrations provide dataset test new algorithms iii allow comparison proposed methods based set standard metrics benchmark consists seven different cases increasing difficulty case specific number sensors calibration signals type floor excitation forces considered paper also proposes specific metrics enable direct comparison different techniques research groups interested monitoring human activity using floor vibrations encouraged use experimental data evaluation metrics published paper develop methodologies enable community researchers easily compare contrasts techniques better understand type methods appropriate different applications elsevier ltd rights reserved
comorbidity substance use disorders borderline personality disorder sud bpd psychiatric disorders little studied total drug dependent patients evaluated using semistructured interviews sud bpd patients multivariate analysis gender affective disorder anxiety disorder eating disorders cocaine dependence early age onset drug consumption dependent antisocial personality disorders associated sud bpd several psychiatric comorbidities norm sud bpd patients therefore patients challenge clinicians
individuals autism spectrum disorder asd characterized severe deficits social communication whereby nature impairments emotional processing yet specified investigated emotional processing individuals asd controls novel behavioral neuroimaging paradigms compared controls individuals asd showed reduced emotional recognition accuracy behavioral task neural level individuals asd displayed reduced activity insula amygdala complex basic emotions compared controls moreover coupling amygdala complex basic emotions reduced asd group finally groups differed respect relationship brain activity behavioral performance brain activity emotional processing strongly related recognition accuracy asd participants contrast coupling anterior cingulate cortex acc activity predicted behavioral task performance strongly control group results provide evidence aberrant emotional processing individuals asd suggest differences relationship neural behavioral level individuals asd account observed deficits social communication
central basis ecological immunology ideas costs trade offs immunity life history traits physical barrier insect provides key resistance trait shows phenotypic variation colour correlates resistance fungus first examined whether relationship colour variation two aspects architecture hypothesised influence resistance fungal invasion thickness porosity second tested hypothesis tyrosine semi essential amino acid required immune defence act limiting resource larval diet subsequently examining adult thickness found stock artificially selected colour less porous thinner porous showing colour varies two architectural features experimental supplementation larval diet tyrosine led development adult affected thickness sex specific manner however affect two immune traits results study provide mechanism maintenance colour variation species production potentially limited resource constraints differential investments resistance mechanisms sexes elsevier ltd rights reserved
traditional chinese herbal medicine used chinese society years treat diseases inflammation cancer report case nine living aids patients age range treated either unique formula alone switched antiretroviral therapy surprisingly viral loads eight patients undetectable levels june remaining patient low viral load copies counts cells ratios nine patients excellent contributing current good health thus case study suggests potential become functional cure hiv aids
recognized essential nutrient institute medicine significant variation dietary requirement explained common genetic polymorphisms wide ranging roles human metabolism cell structure neurotransmitter synthesis deficiency now thought impact diseases liver disease atherosclerosis possibly neurological disorders found wide variety foods eggs rich sources north american diet providing per mean intakes older children men women pregnant women far adequate intake level established given importance wide range critical functions human body coupled less optimal intakes among population dietary guidance developed encourage intake rich foods
paper presents methodological solution background leakage assessment water networks competition methodology employs two constrained multiple objective optimization problems implemented context software application generic hydraulic optimization benchmarking water distribution system problems objectives combined infrastructure operational costs system wide leakage minimized order accelerate evaluation potential solutions distributed computing approach permits multiple solutions evaluated parallel pressure driven demand extension optimization accurately ranking near feasible solutions dynamically allocate leakage demand nodes pressure reducing valves located two ways priori respect optimization analysis infrastructure optimization reduce excess pressure pipe leakage latter demonstrates better overall fitness leading optimal configurations obtained former several temporal resolutions settings evaluated contrast optimal solutions computational effort required american society civil engineers
methyl aspartate receptors major targets acute chronic alcohol regulators plasticity number brain regions aberrant plasticity contribute treatment resistance high relapse rates observed recent work suggests chronic alcohol treatment preferentially modulates expression subcellular localization containing subunit signaling synaptic already implicated pathophysiology various neurological disorders interact large number proteins glutamate synapse better understanding alcohol modulates proteome needed employed discovery based proteomic approach subcellular fractions hippocampal tissue chronic intermittent alcohol exposed mice gain insight alcohol induced changes signaling complexes protein enrichment analyses revealed changes association post synaptic proteins including glutamate receptor domain binding proteins particular interaction glutamate receptor dependent long term depression ltd associated proteins arc increased decreased accordingly found lack induced ltd adrenergic receptor induced ltd remained intact hippocampal following data suggest specifically ltd representing possible connection receptor signaling studies demonstrate new way alcohol modulate plasticity hippocampus also emphasize utility discovery based proteomic approach generate new hypotheses regarding alcohol related mechanisms
background anxiety disorders highly prevalent people bipolar disorder clear many anxiety disorders even times free major mood episodes aimed establish proportion individuals bipolar disorder meet diagnostic criteria anxiety disorders method performed random effects meta analysis prevalence rates current dsm iii dsm defined anxiety disorders disorder social anxiety disorder generalized anxiety disorder specific obsessive compulsive disorder post traumatic stress disorder anxiety disorder otherwise specified adults bipolar disorder studies published december results across samples individuals bipolar disorder met diagnostic criteria one anxiety disorders confidence interval direct comparison individuals bipolar disorder population controls across three studies showed fold increase risk ratio prevalence anxiety disorders bipolar disorder conclusions findings suggest anxiety disorders common people bipolar disorder even mood adequately controlled people bipolar disorder routinely assessed anxiety disorders anxiety focused treatment initiated indicated
whether accurate assessing emotions others emotion recognition accuracy era question gained much interest yielded mixed empirical results present study investigates whether actual hierarchical relationship differ era investigated recruited one direct total took paper pencil version standardized era test results showed accurate assessing emotions persons
purpose investigate breastfeeding initiation duration affect likelihood overweight obese children aged design cross sectional data national survey childrens health setting rural urban areas united states subjects households least one member ages sample size measures parent reported body mass index breastfeeding initiation duration covariates gender family income education ethnicity child care attendance maternal health physical activity residential area analysis partial proportional odds models results early childhood children higher probability normal weight lower probability obese compared children never children less months lower probability normal weight higher probability obese respect children months conclusion study findings suggest length breastfeeding whether exclusive associated lower risk obesity early childhood however caution needed results limitations analysis based findings study others breastfeeding promotion policies potential protective effect breastfeeding weight early childhood
background classic example high reliability organization organization catastrophic events expected occur without control measures health care systems transition toward high reliability practices increasingly transferred clinical implementation methods pubmed search using terms resource management patient safety undertaken physician accident investigation regulations analyzed subject matter experts involved adoption practices medical field interviewed results pubmed search yielded results relevant inclusion improved clinical outcomes noted five research trials practices adopted particularly regard checklist usage resource management training effectiveness interventions influenced intensity application leadership involvement provision staff training usefulness incorporating investigation techniques established whereas accident investigation highly standardized investigation medical error characterized variation discussion adoption practices clinical medicine facilitates evolution toward high reliability evidence efficacy checklist resource management training accident investigation practices preliminary standardized independent investigation process facilitate development safety culture achieved industry
gene expression profiling nucleus area lateral hypothalamus used identify genes regulated hypothalamus putative transcription regulator cysteine rich domain containing zinc binding protein previously described brain found cycle hypothalamus peak levels mrna expression dark phase mrna brain type fatty acid binding protein found change hypothalamic extra hypothalamic brain regions reaching peak levels early light phase suggesting lipid metabolism circadian regulation astrocytes expressed genes nucleus identified compared previous reports meta analysis genes held common included period gene also identified genes implicated mediated signaling pathways included dexamethasone induced ras related protein one regulator protein signaling ras like family member northern blotting confirmed diurnal changes mrna expression hypothalamus genes ras like family member examined detail using situ hybridization diurnal changes expression nucleus nucleus identified gene circadian related mediated signaling transcription protein acid acid rich terminal domain previously identified brain enriched nucleus discrete regions hypothalamus potential regulatory role interacting acid acid rich terminal domain transcription genes like tgf alpha protein diurnal activity rhythms results demonstrate ability gene expression profiling identify potential candidates important circadian homeostatic processes published elsevier ltd behalf ibro
fault cutting algorithm important applying three dimensional numerical manifold method engineering simulation paper presents primary approach fault cutting algorithm including data structures fault cutting procedures basic computing algorithms first data structures physical elements mathematical covers proposed single linked lists linked list arrays respectively reduces complexity algorithm increases efficiency connecting physical elements covers second strategy recording cutting traces every two faults ensure model actual situation proposed strategy also reduces complexity improves efficiency third mathematical covers physical elements cut faults independently process complete cutting instances form incomplete cutting instances without forming new block finally four cutting examples presented demonstrate proposed fault cutting algorithm correct useful american society civil engineers
background cardiac fibrosis play key role atrial fibrillation pathogenesis underlying potential molecular mechanism still understood however potential mechanisms mir upregulation role cardiac fibrosis remain unclear controls cell proliferation processes fundamental disease progression methods study immunohistochemistry real time pcr cell transfection cell cycle cell proliferation western blot used respectively results demonstrated tumor suppressor cell adhesion molecule potential target mir study revealed mir regulation expression decreased cardiac fibroblasts fibrosis tissue cardiac fibroblasts transfected mir mimic promoted mir overexpression enhanced expression decreased expression nevertheless cardiac fibroblasts transfected mir inhibitor obtained opposite expression result furthermore mir suppressed cardiac fibroblast proliferation conclusions results suggested mir overexpression promotes cardiac fibrosis via signaling pathway decrease expression indicating mir important signaling molecule cardiac fibrotic remodeling
high speed machining advanced technology significantly developmental potential due drastic market competition development new materials improved demand component quality shortening product life cycle complexity product development manufacturing high speed machining technology develops rapidly process conception realized technology plays important role chinese article technology application aerial manufacturing introduced summarizing key factors current application innovative mode manufacturing engineering management proposed mode achieve optimization cost
novel duct developed using dielectric dielectric lightweight high elastic energy density large deformation high voltages smart material used fabricate new generation actuator acoustic performances duct experimentally investigated transmission loss measurement system using two load method found resonance peaks new duct controlled applying various voltages maximum resonance shift resonance peaks achieved indicated duct adjusted absorb broadband range noise without addition mechanical part furthermore resonance shift multiple mechanisms using proposed discussed present paper aiming achieve broadband noise reduction present results also provide insight appropriateness absorber possible use new acoustic treatment replace traditional acoustic treatment
paper hydraulic performance self healing capacity geotextile clay containing various amounts nano clay studied nano clay employed substitute portion comparison hydraulic performance self healing capacity common geotextile clay geotextile clay without additives also experimentally studied novel instrument developed evaluate self healing capacity geotextile clay samples limits free index modified samples also measured experimental results showed nano clay considerably reduces hydraulic conductivity geotextile clay also improves self healing capacity geotextile clay free index liquid limits specimens containing nano clay considerably higher normal specimens concluded factors affecting free index change self healing capacity geotextile clay study specimen containing nano clay showed best performance hydraulic conductivity self healing capacity among specimens final effect nano clay inclusion permeability showed analytical model using results surface tension measurements
water plays important role human since ancient times people started regions ensured water availability trade important factor development road important route used trading china countries across many goods including trading processing lead release large amount wastewater study carried understand processing affected groundwater quality road sites studying current scenarios groundwater quality near industries nearby cities chosen case studies groundwater quality around poor due high electrical conductivity concentration due effluents released ground open without proper treatment similarly processing road sites also affected groundwater quality
purpose purpose study estimate population size men sex men msm hiv testing history methods conducted structured interviews msm four geographically disparate cities city implement four population estimation methods ascertain hiv testing history results approximately men corresponding similar individuals aged msm sample reported taking hiv test far exceeds reported msm surveillance data conclusion hiv testing surveillance underestimated number msm underscores need social structural barriers hiv testing disclosure sexual behavior experienced msm recommendations include promoting cultural sensitivity among testing staff quality assurance regular training increasing protection public awareness policy development
objectives studied practice using nurse telephone follow physician direction assess symptom improvement patient satisfaction methods women recruited clinical care nurse telephone follow opinion attending physician women specified preferred telephone number completed symptom questionnaire time enrollment nursing telephone follow completed interval prescribed attending physician answer specified clinical questions approximately months initial office visit satisfaction questionnaire repeat symptom measure subjects results convenience sample women analyzed reached telephone returned follow questionnaire mean age years range years younger women less likely able contacted telephone less likely return questionnaire common diagnoses overactive bladder mixed urinary incontinence satisfaction rates high level convenience patients high women indicated ease speaking telephone condition confidence treatment plan satisfaction telephone follow significantly differ based age diagnosis conclusions patient satisfaction high nurse telephone follow replace office visits selected diagnoses care strategy deserves consideration reimbursement purposes health care evolves
paper discusses procedures development experimental investigation solar collector air heating using solar energy collector consists solar energy made stainless sheets according total aperture area focus heat absorber tube assembled specific form separate elements wall density black colour placed form absorber elements creating turbulent air flow absorber tube increases heat exchange wall air flow intensity absorber tube created electric motor fed direct current produced amorphous silicon flexible photovoltaic module september day efficiency collector heated air temperature increment reached degrees air used room heating drying needs
aims investigate pain sensitivity using quantitative sensory testing older women without headache methods total older women mean age standard deviation years headache healthy controls years participated study pain thresholds pressure heat cold heat pain ratings degrees degrees degrees measured muscle upper cervical spine anterior muscle analysis variance used determine differences pain outcomes groups results compared control group cold pain threshold headache patients significantly decreased upper cervical region anterior muscles significant group differences pressure pain threshold heat pain threshold heat pain ratings sites conclusion older women headache localized pain sensitivity cold stimuli suggesting peripheral mechanisms underlie
recent methods detailed accurate biomass carbon stock estimation forests driven advances remote sensing technology conventional approach biomass estimation heavily relies tree species site specific equations based destructive methods paper introduces non destructive laser based approach terrestrial laser scanner individual tree biomass estimation royal forest reserve malaysia study area state park believed one oldest world point clouds generated forest plots using terrestrial laser scanner geo produce separate point clouds individual trees volumes tree estimated based cylinder model fitted point clouds tree calculated volume species wood density branches leaves also estimated based estimated volume density values branch leaf volumes estimated based fitted point clouds using alpha shape approach estimated individual biomass total ground biomass compared biomass value estimated using existing equations individual tree census data collected field results show combination simple single tree stem reconstruction wood density used estimate stem biomass comparable results usually obtained existing equations however several issues associated data method used branch leaf biomass estimations need improvement
article highlights social work critical thinking care geriatric teamwork promote elderly offer paradigm cultural empowerment reduce power imbalances service providers elderly persons communities force field analysis considers patient protection affordable care act care organizations understand driving forces affecting inter teams effective evidence based models geriatric services offered counter current biomedical emphasis medicare medicaid policies less responsive geriatric institutional educational systems highlight model practices address negative effects moral case lesbian gay bisexual trans questioning multiple health issues analyzed biomedical person environment strength based perspective
groundwater plays important role socioeconomic development watershed despite significance groundwater sustainable development always properly managed watershed therefore study seeks identify groundwater potential zones watershed using geographical information systems remote sensing analytic hierarchy process technique groundwater potential zones thus obtained divided five classes validated recorded yield data found plain northwest along river high groundwater potential zone covers area watershed high groundwater potential zone found eastern part along covers area moderate zone covers area found higher elevation plain poor poor groundwater potential zone covers watershed terrain located southern central parts study area poor groundwater potential zone due higher degree slope low permeability soil type groundwater potential zones watershed helpful future planning development management groundwater resources
paper presents distributed approach scales segment tree within lidar point cloud representing arbitrarily large area approach uses single processor tree segmentation algorithm building block order process data delivered shape parallel distributed processing performed master manner master maintains global map coordinates segment tree within across boundaries minimal bias introduced number detected trees trees lying across boundaries quantified adjusted theoretical experimental analyses runtime approach revealed near linear speedup estimated number trees categorized crown class associated error margins height distribution detected trees aligned field estimations verifying distributed approach works correctly approach enables providing information individual tree locations point cloud segments forest level area timely manner used create detailed remotely sensed forest although approach presented tree segmentation within lidar point clouds idea also generalized scale processing big spatial datasets
national partner countries international trade manufacturing engineering engineering technology advances different degrees impact paper analyzes development chinas manufacturing variations export trade theory explain export trade impact mechanism finally industry grouping according manufacturing industry technical standards industry size compared regression results grouped reasons differences empirical analysis based main conclusions drawn papers put forward relevant policy recommendations
effective temperature control vehicle climate chamber investigated temperature regulated electrical power valve opening water system cooling load water flow rate adjusting valve studied based distributed parameter model developed previous article order ensure flow capacity increase linearity cooling side control output air temperature two equal percentage valves applied climate chamber characteristics large thermal inertia non linearity performance integral derivative pid controller used existing system satisfactory fuzzy self tuning pid controller designed pid gains tuned online according temperature error error change rate air velocity using fuzzy logic model predictions showed fuzzy pid control stabilized air temperature shorter time smaller overshoot time averaged temperature error reduced degrees degrees high temperature test low temperature test reduced degrees degrees elsevier ltd rights reserved
background syndrome common human genetic disorder caused chromosome individuals syndrome present range health issues lives require imaging diagnosis therefore play significant role management communication syndrome patients health purpose review identified patient centered strategies use provide quality imaging services syndrome patients limited verbal ability behavioral issues method systematic review using established prisma guidelines undertaken current literature obtained scopus databases total articles found categorized analyzed detail findings high level care syndrome patients require longer usual procedures patients respond ignored syndrome patients difficulty yet understand often thought individuals require increased imaging time give time respond especially pain patients risk injury pathologies caution taken flexion extension spine rays radiographs reveal physical abuse conclusion specific strategies verbal nonverbal communication help facilitate communication reduce anxiety fear improve compliance syndrome patients patients require increased level care increased imaging time allowing support people present examination process
objectives wealth studies provide evidence action simulation language comprehension recent research suggests action simulations sensitive fine grained information speed present crucial test action simulation speed language assessing speed comprehension patients parkinsons disease based patients motor deficits hypothesized speed motion described language modulate performance semantic tasks specifically difficulty processing language relatively fast speed language slow speed methods conducted semantic similarity judgment task fast slow action patients age matched healthy controls participants decide two closely matched target word results compared controls patients slower making judgments fast action judgments slow action suggesting impairment processing language fast action moreover impairment specific describing fast action performed hand conclusions problems moving quickly lead difficulties language moving quickly study provides evidence speed important part action representations
mini consists items relevant balance deficiencies among people parkinsons disease however mini construct validity evaluated population therefore aimed investigate hypotheses mini results worse among compared healthy controls moderate compared mild motor severity iii history recurrent compared non recurrent falls moreover relationship mini tests similar different constructs expected moderate strong poor respectively materials hundred five mild moderate motor severity healthy controls included divided subgroups based motor severity fall history main outcome measures mini timed original unified parkinsons disease rating scale part activities daily living independent tests spearmans rho used analyses resultsthe mini results worse among compared controls among people moderate motor severity compared mild severity however differences found recurrent non recurrent spearmans rho showed moderate poor correlations convergent divergent validity part respectively mini appears adequately measure dynamic balance among mild moderate severity although unable distinguish recurrent non recurrent
objectives demonstrate racial differences preventable risk behaviors practices contribute head neck cancer study sectional analysis large national risk factor survey methodsthe behavioral risk factor surveillance system analyzed demographic data extracted including age sex race social habits considered risk factors also extracted including alcohol consumption smoking human papillomavirus hpv vaccination status statistical comparisons conducted according race risk factor additional comparisons conducted within american indian population subgroup risk factors according sex resultsa total million americans surveyed american reported higher rates binge drinking whites asian americans rate significantly higher american indian males versus females mean total per month higher whites american american reported highest rates current smoking followed whites asians american also reported highest rates every day smoking versus whites asians rates hpv vaccination lowest american compared whites asians striking racial disparities prevalence preventable risk factors data highlight need targeted education prevention programs particular racial groups level
cable conductor cooled forced circulation supercritical heat exchange bundle region play significant role conductor safe operation remaining quite uncertain parameter heat exchange bundle depends relative contributions convective heat transfer due flow inside bundle thermal resistance due cable order thermal coupling realistic operating conditions dedicated experiment sample field conductor designed performed test facility several methods choice made assess bundle heat transfer coefficient measuring temperature solid copper cylinder inserted conductor submitted heat deposition outer surface mock manufactured tested spring bundle heat transfer coefficient found range results analysis suggests order magnitude convective heat transfer coefficient inside bundle closer reynolds analogy correlation bundle thermal coupling mainly limited thermal resistance due model based equivalent layer proposed showed good consistency experiment relevant values layer thickness elsevier ltd rights reserved
human resistance chemotherapy leads treatment failure previous studies indicated cancers increased levels aerobic glycolysis insensitive numerous forms chemotherapy respond poorly radiotherapy whether glycolysis serves key role drug resistance cells remains unclear present study systematically investigated aerobic alterations regulation multidrug resistant sensitive cells association drug resistance cell proliferating activity assessed mtt colorimetric assay glycolysis including glucose consumption lactate export key enzyme activity determined corresponding commercial testing kits expression levels lactate dehydrogenase glucose transporter akt mammalian target rapamycin mtor mtor myc hypoxia inducible factor alpha hif alpha analyzed western blot reverse transcription quantitative polymerase chain reaction qpcr cells exhibited increased glucose consumption lactate accumulation increased lactate dehydrogenase pyruvate kinase activities reduced activity addition cells expressed significantly notably inhibition glycolysis effectively sensitive resistant cells restored sensitivity cells anticancer agent akt serine threonine kinase akt mechanistic target rapamycin mtor signalling pathway crucial regulator homeostasis mediated activation upregulation myc expression levels cells directly stimulated glucose consumption enhanced glycolysis conclusion present study demonstrated cells exhibit increased aerobic activity responsible resistance cells via activation akt mtor myc signalling pathway therefore inhibition aerobic glycolysis potential therapeutic strategy efficiently treat multidrug resistance relapsed refractory cancers
extend recently proposed depth integrated finite volume solver nonlinear shallow water equations non pressure distribution proposed model aimed simulating nonlinear dispersive shallow water processes split total pressure dynamic components solve problem non problem sequentially framework fractional time step procedure dispersive properties achieved incorporating non pressure component governing equations governing equations depth integrated continuity equation depth integrated momentum equations along directions unlike previous non shallow water solver momentum equation retain vertical local convective acceleration terms former solver keep local vertical acceleration term paper investigate effects convective terms possible improvements computed solution terms neglected governing equations especially strongly nonlinear processes presence convective terms vertical momentum equation leads numerical solution procedure quite different one previous solver dynamic steps spatial domain using unstructured triangular meshes satisfying generalized property numerical solver shock capturing easily addresses drying problems without additional equation solve wet dry interfaces present several numerical applications challenging flooding processes encountered practical aspects irregular topography including new set experiments carried hydraulics laboratory university elsevier ltd rights reserved
paper presents edge boosting method output buffer using signal front detection digital control circuit presented architecture detects data clock signal transitions activates additional drive strength fingers output buffer resulting output current increase improves slew rate compensating losses transmission lines presented edge boosting method used circuits standards double data rate universal serial bus peripheral component etc
bay one productive ecosystems northern indian ocean rich community including pacific spp taxonomy genera controversial within indian ocean seem divided discrete units range east west within genus distributed western indian ocean distributed eastern indian western pacific ocean discontinuous distribution throughout pacific ocean two different phylogenetic units known exist one along eastern african coast another one eastern indian west pacific ocean study investigate pacific northern bay sequenced mitochondrial dna control region compared results previously published sequences within genus cases found genetically different populations seem closely related african form pacific form spp seem closely related individuals australia genetic uniqueness populations important evolutionary implications due isolation coastal distribution geographic characterized extreme infusion redistribution recycling biological productivity conservation implications since survival threatened particular fatal interactions suggest particular extreme conditions found bay driving marine
objective examine fatty acid profiles response omega fatty acid omega supplementation associations clinical status treatment response youth mood disorders methods placebo controlled design year olds parallel pilot trials depression bipolar randomly assigned weeks omega supplementation acid epa acid dha omega per day psychotherapy combination placebo mainly acid alone blood drawn baseline endpoint fatty acid levels expressed percent total plasma fatty acids correlational moderator mediator analyses done spss statistics results baseline dha correlated negatively alpha acid acid omega correlated negatively global functioning total omega correlated negatively age diastolic blood pressure moderation baseline moderated response omega supplementation levels sample mean lower dha predicted significantly better placebo controlled response supplementation effects compared placebo omega per day increased epa blood levels dha levels half body weight correlated inversely increased epa dha positively clinical mood response mediation epa increase baseline endpoint mediated placebo controlled global function depression improvement greater epa increase less placebo controlled omega improvement conclusion omega supplementation day increases blood levels substantially smaller children possible response curve explored
soil one common land processes found worldwide certainly severe environment hazard stability ecosystems rapid inexpensive tool remote sensing technology combining measurements soil spectra widely concerned identifying mapping salt effect however effects soil moisture often effects salt soil reflectance spectra soil moisture became major factor restrict soil salinity monitoring soil reflectance high soil moisture content lead failure soil salinity estimation soil reflectance data paper model using exponent function developed estimate soil salt content different moisture levels based control laboratory experiment root mean square error mean relative error respectively model applied estimate wet soil reflectance sum considering effects soil moisture soil salt soil reflectance model reduced estimated error approach presented paper provides new way estimating soil salinity soil spectra various soil moisture conditions potential application large scale mapping
background asp associated venous thromboembolism serious adverse complication associated acute lymphoblastic leukemia lymphoma treatment incidence rate asp related asian cancer patients known methods performed population based study using claim databases including diagnostic medication codes anti cancer treatment asp diagnoses starting date months cessation asp results total patients prescribed asp treatment type lymphoid malignancy including lymphoma patients experienced common site thrombosis upper extremities cerebral vein thrombosis occurred two pediatric patients pediatric patients adult patients suffered respectively lymphoma patients diagnosed asp exposure univariate analysis diagnosis lymphoma adult patient pediatric patient risk factors occurrence however multivariate analysis age remained risk factor odds ratio confidence interval conclusions first largest population based study asian patients lymphoid malignancies treated asp demonstrating adult patients elevated risk thrombosis asp exposure overall incidence asp related amongst patients similar caucasian populations
zero suppressed binary decision diagrams widely used data structures representing handling combination sets boolean functions particular commonly used cad synthesis verification integrated circuits purpose article design error resilient version data structure self precisely design new canonical form called index resilient reduced faulty index reconstructed time number nodes index moreover propose new versions standard algorithms manipulation construction error resilient execution produce index resilient output experimental results validate proposed approach
subclinical hyperthyroidism known associated risk fractures elderly people however studies assessing whether low normal thyroid stimulating hormone tsh levels affect bone density geometry aimed assess influence tsh level bone mineral density bmd geometry elderly euthyroid subjects cross sectional cohort study total men women included analyzed separately subjects divided based serum tsh level bmd geometry measured using dual energy ray absorptiometry hip structural analysis program multiple regression analysis used compute odds ratios osteoporosis lower tsh group association geometry parameters tsh level found femoral neck total hip lower lower tsh group women cross sectional area cortical thickness femur negatively associated tsh level three regions narrow neck femoral shaft however men geometry parameters significantly associated tsh level region ratio bone geometry parameter representing cortical instability significantly higher lower tsh group three regions women men results indicated lower tsh levels euthyroid range related lower bmd weaker femoral structure elderly women
introduction incorrect use leaves seeds plants members general public give rise serious toxicities also known pipe grass frequently used treatment asthma cough alleviate however also tremendous potential abuse cause anticholinergic toxicity serious fatal complications respiratory failure death reported case report present cases two women years old years old admitted emergency department findings anticholinergic toxicity including taking patients pupils widely gastric administration activated fluids performed patients general conditions recovered except however week diameter patients pupils returned normal conclusion misuse plants cause fatal anticholinergic toxicity toxicity though rarely reported plants known cause toxicity usually endemic clinicians alert potential anticholinergic toxicity patients present anticholinergic symptoms endemic areas
anticoagulant heparin shown possess important biological functions vary according fine structure variability within structure occurs owing biosynthesis animal tissue based recovery adds another dimension complex polymeric structure structural variations chain length patterns mediate interaction many heparin binding proteins thereby eliciting complex biological responses advent novel chemical enzymatic approaches synthesis coupled high throughput combinatorial approaches drug discovery facilitated increased effort understand structure activity relationships improved understanding offer potential new therapeutic development engineering approach requires several different disciplines including carbohydrate synthesis applied enzymology metabolic engineering process biochemistry
paper studies regularized least squares regression problem arises many applications signal processing machine learning iterative algorithm important algorithm solving problem viewed type iterative method paper proposes version iterative algorithm called solving problem certain conditions establish global convergence eventual linear rate convergence local compared counterpart proposed algorithm allow larger step sizes converge much faster effectiveness proposed algorithm justified numerical experiments synthetic data real data elsevier rights reserved
previous observational research suggests stretching report first experimental evidence response previous experiment testing species using repeated measures design birds tested pairs alongside familiar unfamiliar without visual barriers results show stretching behavior temporally clustered birds see one another previous observational findings supporting additionally first time show ingroup bias response overall frequency stretching significantly differ function familiarity stretching present cage paired together findings discussed relation recent research studying social cognition species
ambient intelligence ami paradigm represents vision next wave computing relying various computing networking techniques ami systems potential enhance everyday lives many different aspects one area widespread application innovative paradigm promises particularly significant benefits health care work presented contributes realizing promise proposing functioning software application able learn behaviors habits thereby anticipate needs inhabitants living technological environment smart house city result health care system actively contribute thereby preventing emergency situations provide greater autonomy safety disabled elderly occupants especially cases critical illness
flow generated oscillating sphere quiescent fluid classical problem fluid mechanics whose solution used ubiquitously mechanical devices small scales operation high frequencies fluid common modern systems use unsteady stokes equation continuum flow explore combined effects gas unsteady motion sphere within framework unsteady boltzmann gross equation equation solved using method characteristics resulting solution valid oscillation frequency arbitrary degrees gas resulting force provides non continuum counterpart continuum unsteady stokes drag sphere contrast stokes solution flow isothermal non continuum effects lead temperature jump sphere surface non isothermal flow unsteady effects heat transport found mix strongly leading marked differences relative steady case solution canonical flow problem expected significant practical value many applications including optical trapping nanoparticles design application systems also provides benchmark computational approximate methods solution boltzmann equation
digital control method combining primary side sensing observer model predictive control techniques proposed conventional isolated converter chosen demonstrating method measured signal drain source voltage switch following procedure signal processing state estimation constraint problem formulation controller determines optimal duty cycle ratio advantages proposed method include minimal overshoot fast stabilization converter state restriction measurement network simplification
compressor model developed characterize time response pressure within compressed natural gas storage tank model assumes compression single stage compressor isothermal reservoir compression heat assumed cylinder tank low order model utilizes key variables compression ratio cylinder volume tank volume engine speed yields reasonable approximation pressure inside tank time natural gas compressor used validate model unique automotive internal combustion engine heavily modified two distinct modes one mode engine fire normally providing locomotion natural gas vehicle mode one cylinder engine used low pressure residential natural gas multiple stages standard compressed natural gas vehicle storage tank pressure bar gauge found first order response model closely matches trend tank pressure time seen laboratory experiments typical error less
objective study weighted average global prevalence migraine community level study design setting systematic review using advanced search strategies employing pubmed medline scopus web science conducted community based non clinical studies combining terms migraine community based names every country worldwide spanning previous years january august methods accordance prisma guidelines meta analysis subgroup analysis performed identify pooled migraine prevalence examine cohort heterogeneity results total community based studies involving participants median age years male female ratio included global migraine prevalence random effects africa asia europe north america central south america pooled cohort stratified prevalence among females among males among urban residents among rural residents among school college students result showed pattern rising global migraine prevalence conclusion migraine affects one ten people worldwide featuring recent rise higher prevalence found among females students urban residents elsevier rights reserved
background chinas rapid urbanization past decades exacerbated problems environmental degradation health disparities however studies analysed differences urban rural residents relation environmental quality impacts health outcomes study examines associations chinese peoples perceptions environmental quality self rated health particularly focusing differences rural urban residents environment health relationships methods using logistic regression model data chinese general social survey representative sample data urban residents years rural residents years analysed dependent variable used logistic regressions whether respondents reported healthy independent variables included respondents evaluations living environment frequently participated physical activities interaction terms employed measure moderating effects physical exercise relationship perceived environmental quality health results percentage healthy urban residents significantly larger healthy rural respondents versus urban respondents living areas sufficient green space likely report good health rural respondents without reliable access fresh water likely report poor health urban respondents exposed green spaces frequently per cent likely report good health lived areas insufficient green space frequently per cent less likely report good health evidence suggested physical exercise exerted moderating effect relationship exposure air pollution health conclusions average urban residents better health rural residents among four indicators low environmental quality air pollution lack green spaces water pollution uncertain access freshwater resources green space important determinant urban residents health status unreliable access fresh water rural residents health physical exercise moderated effects exposure green spaces urban residents health
electromagnetic structure phase shift introduced operation connection double steps rectifier discussed algorithm main design quantities machine described circuit model circuit analysis allows quantities machine design performed inputs thermal analysis results thermal analysis machine designed built authors shown
objectives aim explore experiences iranian postmenopausal women sought medical help symptomatic atrophy methods five focus group discussions conducted participants postmenopausal symptoms came clinic previously sought medical help confirmed physical signs upon examination results twenty five women aged years participated five twenty women said currently symptom presentation clinic four major themes emerged womens narrative stories negative impact womens life psychological distress associated negative impact marriage relationship inadequate symptom relief available treatments due lack awareness treatment options none participants reported ongoing treatment local low dose estrogen women although local estrogen products costly like use prescribed conclusions considering negative impact symptoms womens lives health professionals iran prescribing approved effective therapies symptomatic women
background variation gene alters rate nicotine metabolic inactivation associated smoking behaviors cessation success rates underlying neurobiological mechanisms genetic influence unknown methods intrinsic functional connectivity strength whole brain data driven graph theory based method applied resting state functional magnetic resonance imaging data smokers subset subjects smokers performed monetary incentive delay task probing reward anticipation task probing response inhibition two occasions presence absence nicotine patch results significant genotype smoking effect found dorsal anterior cingulate cortex ventral striatum normal slow genotype individuals showed greater functional connectivity strength among smokers functional connectivity strength negatively associated severity nicotine dependence slow biased inputs insula identified seed based connectivity similar gene environment interactions seen ventral striatum smoking abstinence subjects performed monetary incentive delay task dorsal anterior cingulate cortex performed task reductions normalized smokers increased acute nicotine administration conclusions effect seen smokers data suggest rate nicotine metabolism thus concentration nicotine presented brain course nicotine addiction shapes brain circuits among functions compute reward impulsivity processes
angiotensin plays major role vascular matrix tissue inhibitors involved tissue processes aim present study investigate whether modulates expression rat aortic smooth muscle cells vivo angiotensin per min per day normal saline administered continuously osmotic sprague dawley rats week addition effect endogenous expression evaluated hypertensive rats two kidney one one kidney one models control rats sham sham rats underwent sham left renal artery end treatment plasma activity measured aortic mrna expression evaluated real time polymerase chain reaction northern blotting protein expression evaluated immunohistochemistry systolic blood pressure measured twice week tail method exogenous administration produced expected increase compared control saline treated group increase abolished treated rats administration caused significant increase expression rat aortic smooth muscle cells abolished treated rats hypertensive rats higher rats compared corresponding sham operated rats plasma activity higher rats compared groups expression significantly increased rats vivo data demonstrate exogenous endogenous increases expression rat aortic smooth muscle cells effect dependent induced increase blood pressure mediated angiotensin receptors
physical conception labs opened possibility combining new fundamental circuit element traditional devices order carried novel applications important step incorporating computer aided design tools find expression represents behavior device paper novel modeling methodology systems using perturbation methods introduced methodology capable generating semi expression represents behavior device new model characterized order impact variables behavior establishes range compliance using principal besides novel model depicted two cases study finally advantages model presented discussed
system dynamics computer simulation modeling methodology one suitable effective ways dynamics modeling complex non linear natural technical organization systems studying dynamics behavior marine electric power systems one complex dynamic non linear technical systems requires application effective modeling methods aim paper show efficiency system dynamics computer simulation modelling dynamics behavior marine diesel drive generating set one complex non linear marine technical systems marine diesel drive generating set presented qualitative quantitative system dynamics computers model special automation aspect provided two pid regulators electronics universal pid regulators one used diesel motor speed frequency regulation used synchronous electrical generator voltage regulation
social perception among important tasks occur daily life perceivers readily social others demonstrate sex functionally biased towards male perceivers judged body shapes varied waist hip ratio men reality exclusive women male occurred quickly female studies pattern corroborated participants identified average body shapes men women study assessed participants cognitive representations study moreover tendencies modulated emotion context study thus male occurred readily rapidly demonstrating pronounced categorization bias temporal advantage male
ability differentiate individuals group useful forming impressions social categorization fails method particularly valuable incongruent social category female tested notion initiated applying cognitively explanatory emergent attributes incongruent incongruent category likely comprised emergent attributes moderated application attributes experiment experiment moderated emergent attribute application incongruent cognitive load attenuated relationship allowing preventing generation attributes affect incongruent experiment ruled possibility emergent attributes cause increased rule notion explanatory attributes together findings suggest whose category applied application explanatory emergent attributes
controlling groundwater always great concern tunnel management tunnel drainage system function properly due insufficient drain capacity become sediment calcium study various types investigated laboratory evaluate filtration discharge capacity characteristics potential use drain capacity compared needle non woven geotextile currently used drain layer material based results discharge capacity tests performed four types found meet filtration requirements presence calcium water found result decrease approximately maximum discharge capacity pressure kpa also maximum reduction observed discharge capacity approximately pressure increased kpa comparison non woven needle geotextiles however revealed significantly larger discharge capacity non woven needle geotextiles similar thickness approximate average times larger moreover discharge capacity relatively less affected pressure compared non woven needle geotextile elsevier ltd rights reserved
social categorical knowledge partially grounded study participants describing hard soft politicians hard soft scientists used different hard soft traits two groups suggesting meaning traits context specific studies showed meanings supported hard soft consistent political stereotypes perceivers viewing faces handling hard ball likely categorize rather compared perceivers viewing faces handling soft ball study similarly consistent stereotypes hard soft academic disciplines perceivers likely categorize photographs handling hard versus soft ball study finally thinking led participants perceive ball respectively suggesting simulating aid social categorical thinking study
study presents approach system identification adaptive control non inverting buck boost converter presence large signal changes uncertainty converter components effects modelling feedback loops converters typically designed closed loop regulation stability margins maintained pre determined range operating conditions proposed approach able keep high performance response without instability issue dynamic change converter presence uncertainty parameters converter digital adaptive controller based system identification minimum degree pole placement proposed verify validity proposed digital controller experimental setup constructed non inverting buck boost converter fully digital adaptive control implemented micro controller experimental results show capability adaptive controller different operating points
article present new kind controllable electromagnetic structure applied stealth design stealth technology future transmission coefficient electromagnetic wave single radar cross section structure electrically controlled simulated characterized ghz structure constructed split ring metallic wire arrays including pin diodes pin diodes periodically inserted discontinuous control electrical continuity wires either state state depending voltage simulation test prove structure absorb incident wave reduced largest scope around frequency wiley periodicals inc
purpose review aimed review invasive fungal infections primary pid recent findings several pid predisposing fungal infections recently deficiency selectively fungal infections including deep frequent central nervous system location especially candida infection patients heterozygous function mutations mostly chronic also display even though less frequently invasive fungal infections deficiency also major concern patients lung antifungal prophylaxis recommended first group patients previously reported pid known predispose fungal infections genetic defects ifn gamma axis predispose fungal infections summary patients developing invasive fungal infections including disseminated infections caused fungi without known underlying risk factors explored order diagnose primary even absence previous infectious episodes
background aim assess influence long term treatment tumor necrosis factor alpha tnf inhibitors total cholesterol triglycerides low density lipoprotein ldl high density lipoprotein hdl index rheumatoid arthritis psoriatic arthritis psa ankylosing spondylitis patients methods retrospective cohort study conducted psa patients treated tnf inhibitors least days levels ldl hdl compared baseline values months patients subdivided three groups according coa reductase inhibitor treatment status order assess effect results results records patients psa reviewed increased following treatment tnf inhibitors baseline months respectively months respectively increased following treatment tnf inhibitors baseline months ldl decreased significantly patients treated entire study period baseline months contrast increase ldl values patients receive study conclusions tnf inhibitor treatment associated significant increase levels adding treatment associated significant decrease ldl levels
digital pcr powerful method absolute quantification rare mutation detection nucleic acids however available platforms require either expensive instruments complicated operation limit extensive application paper describes robust self partition chip perform simple inexpensive format chip constructed surfactant doped layer two glass containing reaction compartments two simple strategies glass glass sandwich configuration surfactant doped surface modification used enhance pcr compatibility enable efficient amplification chip minimizing water loss nonspecific adsorption protein furthermore powered pre substrate attached chip autonomously loads sample high density array performing analysis evaluated quantitative capabilities chip measuring ten fold serial dilution genomic dna lung cancer cell line finally also demonstrate feasibility accurate measurement small copy number variations exhibited better accuracy real time quantitative pcr qpcr simple low cost platform promises accelerate widespread use elsevier rights reserved
semi markov process structure represented full graph loops simulates digital control algorithm generated transactions onto object investigated elementary reduction semi markov processes defined recursive procedure reduction initial semi markov process structure till model includes selected states links proposed formulae probabilities weighted densities expectations time switching linked states obtained shown recursive procedure used also calculation time expectation return process one selected states simplified task evaluation time intervals transactions procedure
modifiable unit problem ecological known problems occur modelling multiscale spatial processes investigate forms spatial aggregation error guide spatial domain interest mean specification define spatial support data topic studied given less attention spatial thus propose criterion spatial aggregation error minimize obtain optimal define criterion draw connection spatial aggregation error new multiscale representation expansion relationship criterion spatial aggregation error multiscale expansion leads theoretical developments including connections spatial aggregation error squared prediction error spatial variance novel extension effectiveness approach demonstrated analysis two data sets one using american community survey one related environmental ocean
special diets consumed treatment diseases food allergies diabetes intolerance disease lifestyle related diets weight reducing sports low carbohydrate diets also called special diets aim study examine frequency reasons special diet consumption therapeutic measure lifestyle related choice among year old nationwide cross sectional data collected self administered questionnaires number respondents varied response rates ranged consumption special diets therapeutic purposes lifestyle related choice showed significant increasing trend year olds study period frequently reported single diets adolescents intolerance diets however fluctuation trend observed consumption different lifestyle related diets growing number respondents especially girls reported simultaneous consumption combination two therapeutic lifestyle related diets reason choosing therapeutic diet seems stay constant studied period contrast wide variety reasons health wellbeing body weight ethical ideological reasons avoidance specific foods given consumption lifestyle related diets study results correspond increased prevalence common illnesses finland data also reveal properties special diet consumption among adolescents long run highlights need educate finnish adolescents nutrition literacy
stress episodic memory impairment previously associated acute stress disorder asd maladaptive stress response develops individuals following traumatic life events recently authors demonstrated specific deficit associative memory emotionally neutral stimuli asd posttraumatic stress disorder ptsd study tested relationship memory impairment course asd assessed new learning memory item associative information patients diagnosed asd matched trauma naive controls memory performance posttraumatic symptoms examined approximately week periods following traumatic experience two experiments participants studied list stimuli pairs verbal visual tested memory items item recognition test association items pair associative recognition test experiments asd patients showed marked associative memory deficit compared control group weeks asd symptoms resolved patients interestingly performance associative recognition verbal stimuli improved associative deficit visual stimuli remained unchanged potential mechanisms underlying associative memory deficit patients discussed elsevier ireland ltd rights reserved
advances sequencing technologies continue provide unprecedented opportunities characterize microbial communities example pacific single molecule real time platform emerged unique approach harnessing dna polymerase activity sequence template molecules enabling long reads low costs aim simultaneously classify situ microbial populations developed quantitative approach involves addition exogenous standards quantify ribosomal derived environmental samples regions rdna targeted quantified community samples collected sea summer used three standards different length optimized conditions obtain accurate quantitative retrieval across range expected sizes necessary criterion analyzing diverse rdna molecules natural environments ability concurrently identify quantify microorganisms natural environment makes powerful rapid cost effective approach defining ecosystem diversity function elsevier rights reserved
development process complex production machines requires intense collaboration different technical disciplines context interdisciplinary development team often lacks common continuously updated system model machine consequently lead high communication effort delays overall development process efficient effective production machine design process interdisciplinary modeling language required follows generic design approach therefore analyzed existing modeling languages identified drawbacks concerning application machine design based findings developed interdisciplinary modeling language combining benefits existing languages extensions includes three diagram types functional structure interaction structure sequential behavior diagram furthermore propose diagrams integrated general machine development process demonstrate utilization basis use case
brain food tryptophan substances vitamins magnesium thought beneficial obesity inflammation insulin resistance present pilot study hypothesised specific amino acid mixture improves cardiometabolic situation chronically stressed persons cardiovascular metabolic parameters analysed per protocol patients chronic stress disorders patients assessed psychological neurological questionnaire dietary intervention reduction fasting serum insulin concentrations occurred treatment group association found values insulin concentrations baseline insulin reduction results support use specific dietary supplement improved stress management decrease metabolic dysfunction
beside major objective providing congestion control achieving predictable delay maximizing link utilization robustness main objectives active management controller paper proposes improved dynamic model incorporating packet drop probability applying improved model new compensated pid controller developed transmission control protocol internet protocol tcp networks non minimum phase characteristic caused approximation network delay direct application control methods unstable internal dynamics paper parameter varying dynamic compensator operates tracking error internal dynamics proposed capture unstable internal dynamics also reduce effect uncertainties flows proposed dynamic compensator used design pid controller whose gains obtained directly state space representation system gain tuning requirements packet level simulations using network simulator show developed controller delay stability resource utilization improved underlying model leads also faster response controller copyright john wiley sons ltd
previously demonstrated single treatment non delta opioid receptor agonist antidepressant like effect rodents forced swim test evaluated effect repeated administration potential antidepressant olfactory rat model male wistar rats weeks old underwent olfactory days surgery administered either day selective serotonin inhibitor day vehicle daily days measured days repeated administration significantly decreased total individual scores attack struggle fight entire period conversely show significant effect days significantly reduced total score day inhibitory effects greater control groups gained weight group lost weight results suggest potential lead compound antidepressant therapy high efficacy relatively rapid onset therapeutic effect without possible adverse effects weight loss caused published elsevier
spatial structure influence way evolutionary processes date several methods used study evolution spatial systems including population genetics quantitative genetics moment closure approximations individual based models extend study spatial evolutionary dynamics eco evolutionary models based reaction diffusion equations adaptive dynamics specifically derive expressions strength directional stabilizing disruptive selection apply continuous space symmetrical dispersal patches directional selection quantitative trait yields way integrate local directional selection across space determine whether trait value increase decrease robustness prediction validated quantitative genetics stabilizing disruptive selection show spatial heterogeneity always contributes disruptive selection hence always promotes evolutionary expression directional selection numerically efficient hence simulation studies evolutionary community assembly illustrate application utility expressions purpose two examples evolution resource utilization finally outline domain applicability reaction diffusion equations modeling framework discuss limitations
paper novel technique based graph theory introduced solve sparse linear systems proposed technique enhances ability build sparse parallel solvers circuit simulation matrices thus proposed technique improves performance circuit simulation algorithms new technique represents sparse linear system signal flow graph graph separate strongly connected components scc relations represented used enhance parallelism solver
paper proposes approach robust tracking method objects intersection similar target object target image sequences taken moving camera paper tracking methods using color information tend track background region object color similar target object since proposed method based particle filter method constructs probabilistic background model histogram optical flow defines likelihood function likelihood region target object become large leads increasing accuracy tracking probabilistic background model made density forests infer probabilistic density fast proposed method process faster authors previous approach introducing density forests results demonstrated experiments using real videos outdoor scenes
rock among important species eastern coast australia also basis major aquaculture industry industry now largely relies rock selectively fast growth disease resistance selectively currently also sustain wild populations rock providing opportunity led concern gene flow selectively alter genetic variability wild populations use next generation genotype sequencing test genetic wild selectively line rock sites river strong genetic partitioning identified wild selectively populations evidence gene flow form even though selectively river since early contrary expectations also found significantly higher levels genetic diversity selectively population relative wild population relatively low level genetic diversity detected wild particularly relevant adaptive capacity species wild
background reduced bone formation associated increased bone marrow fat many bone loss related diseases including aging post menopause anorexia nervosa several lines evidence suggested regulation bone marrow derived mesenchymal skeletal stem cells mediators study aimed investigate impact adipocytes secreted factors cell proliferation osteoblast differentiation methods serum free conditioned medium collected stromal cells derived adipocytes cell viability quantitative alkaline phosphatase alp activity assay red staining matrix mineralization osteogenic gene array expression performed determine effect cell proliferation osteoblast differentiation primary murine regulation kappa signaling pathways detected western blot analysis gene reporter assay results showed effect cell viability proliferation primary compared control hand significantly inhibited commitment cell lineage dose dependent manner found dramatically inhibit induced osteoblast differentiation activate inflammatory kappa signaling interestingly treatment selective inhibitor kappa pathway showed retrieve inhibitory effect induced osteoblast differentiation conclusions data demonstrated marrow adipocytes exert inhibitory effect osteoblast differentiation blocking signaling mechanism mediated induced kappa pathway activation
paper describes modern enzymology japanese revolutionized world industrial enzyme production fermentation new designated found discovered discovered aspergillus single stranded designated activates demonstrated binding site basic substrate new moieties man man identified yeast mutant compatible producing man human compatible sugar chains constructed acid activation resolved hyper protein production system established submerged culture
biological rhythms essential regulator life evidence circadian rhythm activity disrupted chronic stress animals humans also less marked diseases investigated whether detectable circadian rhythm activity exists dairy commercial settings using real time positioning system used farm technologies regularly record individual positions danish dairy farm infer activity resting feeding factorial correspondence analysis activities used first component analysis express variations activity axis activities obtained following weights resting feeding applying weights proportions time spent activities able chart circadian rhythm activity found average level activity given clay variations day varied specific states specifically circadian variations activity appeared particularly sensitive vary detected disorder findings offer promising avenues research design models predict physiological pathological states real time positioning data
day experiment carried delineate role dietary modulating immunity prevention fungal infection two hundred seventy randomly distributed three treatments three iso caloric purified diets prepared graded levels three experimental groups role dietary modulating immunity prevention fungal infection assessed immunological parameters like erythrocyte counts counts packed cell volume mean volume mean mean concentration blue activity albumin globulin total plasma protein albumin globulin challenge study relative percentage survival recorded total plasma protein albumin globulin contents activity significantly higher fed group significantly higher recorded group fed days hence capacity stimulate nonspecific immunity increase resistance infection elsevier ltd rights reserved
infection freshwater chinese necrosis disease major problem cultivated chinese province since explore etiology meta transcriptomic libraries without constructed comparison analyses showed statistically significant differences viral communities diseased healthy dominant bacterial healthy combined prevalence however decrease bacterial diversity striking shift microbial composition found infected prevalent bacterial diseased whereas prevalence low healthy contrast prevalence significantly lower without also found prevalence higher without disease major bacterial family within detected polymerase chain reaction determined conclusion striking changes microbiota diseased healthy specifically prevalence bacteria belonging increased whereas prevalence bacteria belonging decreased clearly pointing association
coupled green building roof system assess bidirectional heat flux indoor space two high rise residential blocks humid hong kong without roof building thermal insulation monitored thermal performance across seasons weather conditions block three plots peanut green roofs plus bare control diurnal heat flux data partitioned daytime positive negative fractions hot summer day control without facilitates notable daytime influx efflux heat thermal mass effect heat indoor control balance heat sink formation peanut registers intermediate heat gain adding raises heat gain eliminates control heat loss heat gain maintains peanut heat gain green roof offer synergistic thermal benefit increasing thermal mass thermal capacity thermal resistance thermal buffering thermal lag extending heat lower solar radiation input summer day significantly heat gain control limited reduction green roofs summer rainy day brings drop heat gain rainy scenarios heat gain suppression notable interpretations season weather conditions implications findings elaborated elsevier ltd rights reserved
neuropeptide oxytocin facilitates prosocial behavior selective context stress also regulate hypothalamic pituitary adrenal hpa axis activity leading consideration potential treatment many disorders however mechanisms administration exogenous modulates social behavior stressful environmental contexts fully understood investigate hypothesis autonomic pathways components mechanisms aids recruitment social resources stressful contexts elicit behavioral responses female underwent stressor walking shallow water following pretreatment intraperitoneal antagonist allowed recover without administration resulted elevated concentrations plasma hpa axis response stressor however pretreatment prevented functional coupling usually seen absence nucleus activity measured fos immunoreactivity hpa output release furthermore pretreatment resulted functional coupling activity brain regions regulating sympathetic parasympathetic dorsal complex nucleus ambiguous branches autonomic nervous system findings suggest increases central neural control autonomic activity rather strictly hpa axis activity provides potential mechanism facilitate adaptive context dependent behavioral physiological responses stressors published elsevier inc
one abundant whose major amounts formed provide comprehensive description different types different life eukaryotes type mitochondrial enzymes whereas localized cellular compartments describe role mitochondrial proteins function enzymology biogenesis assembly mitochondria contribution phospholipid homeostasis much detail also discuss briefly cellular physiology enzymology article part special issue entitled lipids mitochondria published elsevier
background previous studies postulated association migraine excessive daytime sleepiness eds study evaluated association eds migraine headache frequency general population adjusting potential confounding variables methods study survey random age gender stratified sample persons aged years old drawn national population register norway questionnaire included questions migraine headache sleepiness scale various comorbidities eds defined association eds migraine headache analysed bivariate multivariable logistic regression analyses results total persons responded included analyses odds ratio eds increased compared non however finding significant adjustment number possible confounders eds increased increasing headache frequency days per year compared without headache multivariable analysis conclusions general population odds eds increased significantly headache frequency irrespective migraine status eds associated reported migraine multivariable analysis
smart grid integrates electrical network communication systems information technologies increasing architecture introducing new challenges evaluation possible threats affect security reliability power system cyber attacks widely studied consequences physical failures real time applications starting receive attention due implications power system security paper presents methodology quantify impact observability state estimation possible disruptive failures common transmission infrastructure numerical results obtained calculating observability indicators ieee bus test case considering simultaneous power transmission lines communication links installed infrastructure
internet things iot inspired solutions already available addressing problems various application scenarios healthcare security emergency support tourism however clear approach modeling systems capabilities design time therefore process designing systems hoc real impact evaluated solution already implemented risky expensive paper proposes modeling approach uses human centric wireless sensor networks specify evaluate models iot based systems time design avoiding need spend time effort early implementations immature designs allows designers focus system design leaving implementation decisions next phase article illustrates usefulness proposal running example showing design iot based solution support first responses medium sized large urban incidents case study used proposal evaluation based real train proposed modeling approach used design iot based systems application scenarios support security monitor chronic patients homes
internet based cyber physical world profoundly changed information environment development artificial intelligence bringing new wave research promoting new era one prominent characteristics research era intelligence attracted much attention industry research communities specifically intelligence provides novel problem solving paradigm gathering intelligence address challenges particular due rapid development sharing economy intelligence becomes new approach solving scientific challenges also integrated kinds application scenarios daily life online offline application real time traffic monitoring management paper survey existing studies intelligence first describe concept intelligence explain relationship existing related concepts human computation introduce four categories representative intelligence platforms summarize three core research problems state art techniques intelligence finally discuss promising future research directions intelligence
damage detection full scale nine story reinforced concrete building investigated using forced vibration test building former civil architecture department university located japan earthquake resistance elements building severely damaged earthquake building performed structure sensor arrangement using data acquired sensors system identification performed using rational fraction polynomial damage assessment detection location done modal assurance criterion derivatives results indicate detected damages location using method corresponds actual damages occurred structure
recent heterogeneous system designs integrate general purpose processors gpus specialized accelerator devices single platform provide power performance benefits important support efficient mechanisms terms performance work proposes models integrating hardware applications executing standard operating systems embedded processor instead using direct mapping accelerator units user applications using legacy drivers communication large programming effort develop abstraction layer kernel driver driver custom interface number hardware time remove need include virtual physical translation device side need perform copies user kernel space computational tasks demonstrate effectiveness solutions running real applications prototype hybrid heterogeneous system chip platform
alpha biologically active compounds often monitored blood samples evident importance human metabolism study novel ultra performance liquid chromatographic method used determination vitamins human serum compared conventional hplc particulate monolithic columns sub two particle hybrid stationary phase used separation contrast five particle packed column monolithic column highly porous structure methanol flow rates min respectively used mobile phase compounds three methods detection performed absorption alpha respectively analysis time sensitivity mobile phase consumption validation data cost critically compared different chromatographic systems although cost mobile phase consumption seem make method choice use monolithic column resulted almost separation performance slightly shorter analysis time methods alternatives routine laboratory practice economical means analysis large numbers biological samples use traditional particulate column
small rnas play fundamental roles modifying organisms classified according origin way classes micrornas interacting rnas natural antisense although micrornas conserved studied class expression pattern indicative biological function northern blotting one widely used methods identify validate study expression profile quantitative relatively inexpensive technique readily available laboratories chapter describes protocol northern blot analysis includes rna extraction polyacrylamide gel electrophoresis detection using oligonucleotide probes
climate change important issue human facing sustainable development green building one solutions mitigate impacts climate change concrete one type green material concrete keep runoff rainwater water resource environment preserved heat island effects reduced general concrete used pavement also employed coastal structures artificial fish taiwan paper focused studying characteristics applying designed concrete pavement utility experimental results showed compression strength field specimen exceed specifications normal concrete structure concrete used study capacity water field permeability test simulated field site sec made concrete experimental results showed reduce phenomena wave run comparing made normal concrete specimens furthermore shown surface temperature concrete normal concrete preliminary results study valuable serve useful reference designing constructing concrete future
objective investigate concentration serum matrix metalloproteinase mmp active ankylosing spondylitis infliximab treatment evaluate whether mmp mmp associated clinical measures disease activity function method baseline sequential serum mmp mmp examined week infliximab treatment patients clinical evaluated esr crp paired test spearman correlation analysis used statistic analysis results serum mmp mmp clinical scores including esr crp patients significantly decreased treated infliximab weeks peripheral arthritis patients higher mmp level without patients without patients higher mmp level association found mmp esr crp mmp associated crp weeks decrease mmp associated improvement esr crp decline mmp correlated improvement crp thirty seven responders seven non responders according improvement criteria week infliximab infusion responders higher baseline serum mmp non responders mmp conclusions serum mmp mmp decreased significantly active patients infliximab therapy decline associated improvement clinical syndromes infliximab responders higher baseline serum mmp mmp level infliximab non responders
depression involves dysfunction affective limbic circuitry including prefrontal cortices several limbic structures including cingulate cortex amygdala hippocampus basal ganglia major emphasis research etiology treatment mood disorders assess impact centrally generated top processes impacting affective limbic circuitry present review shows peripheral bottom stimulation via visual auditory modalities physical exercise modulates mood depressive symptoms humans animals activates central affective involved depression proposed amygdala serves gateway mood regulatory sensorimotor stimulation central affective circuitry emotionally labeling mediating storage emotional events long term memory since mood shown possible stimulation review suggests assessment mood modulation multimodal stimulation uncover mood serve adjunctive treatment depression thus integrative review emphasizes relevance investigating optimal levels mood regulatory sensorimotor stimulation also provides conceptual related future research
section model wind tunnel test currently main technique investigate flutter performance long span bridges study applying wind tunnel test results aerodynamic optimization still needed parameters test principle bridge section model determined using three long span steel suspension bridges flutter critical wind different attack angles obtained section model flutter test unfavorable working condition tests investigate effects upper central stabilized plate lower central stabilized plate horizontal stabilized plate flutter performance main beam conducted according test results optimal aerodynamic measure chosen meet requirements bridge wind resistance consideration safety economy last credibility results confirmed full bridge aerodynamic elastic model test flutter reduced wind speed long span steel suspension bridges approximately concluded reference investigation flutter performance future similar steel girder suspension bridges
intimate partner abuse major social problem lead mental health conditions implicated female male deaths hypothesized due distinct relationship structures power dynamics immersed varying sociocultural contexts victims male male female female female male dyads experience different patterns objectives examine demographic clinical characteristics victims male victim male female victim male male victim female female victim female dyads compare patterns reported victims groups subjects general population attempted internet based study english speaking subjects older years experienced provided complete information analysis victims screened specific methods abuse evaluated significantly educated groups experienced abuse age parent relative experienced physical abuse least physical abuse threats abuse front children reported least patterns differ significantly presenting physical profile presenting least
active circuits arbitrary transfer characteristics current mode presented paper given circuits multiple loop feedback structure namely follow leader feedback structure output summation modeling signal flow graph technique used modify transform structure current mode implementations multi output current differencing input given verification illustration shown designed circuits simulated pspice resulting responses confirming theoretical assumptions
inhibition beta currently main pharmacological strategy available alzheimers disease analysis cyclic inhibitors carried using comparative molecular field analysis comparative molecular similarity indices analysis methods best model based training set generated value value value value value value order gain understand vital interactions cyclic protease analysis performed combining field distributions active sites final models helpful design development novel active inhibitors elsevier ltd rights reserved
taste preferences health concerns play important roles determining eating attitudes thus influencing food choices disordered eating attitudes common among women lead development maintenance eating disorders attitudes toward health taste food among patients comparison non clinical women known knowledge improve eating interventions study compared taste preferences health concerns women diagnosis bulimia nervosa women non clinical sample participants completed health taste attitude scale using analysis covariance compared scores patients college students risk behaviors assessed eating attitudes test identified non clinical sample therefore excluded comparison patients non clinical sample compared patients scored higher taste domain subscale whereas patients scored higher health domain light product interest subscale based data eating attitudes women non clinical sample related taste whereas women concerned adopting diet regarded healthy thus increasing interest light products therefore taste health concerns considered nutrition interventions women general prevention treatment determinants food choice elsevier ltd rights reserved
main issue higher education czech republic relating mechanical engineering currently lack opportunities students acquire practical knowledge experience field studies moreover engineering companies czech republic often share universities meaning study machine design isolated practice engineering companies one way deal issues improve different aspects teaching technical subjects order improve quality efficiency attractiveness machine design faculty mechanical engineering university west launched machine design teaching enhancement project whose goal provide students academics quality learning materials learning materials concerned teaching computer aided engineering systems developed part step step learning materials promote self study make learning systems much easier students another part concerned developing new concept project based learning materials based interactive models learning materials developed academics cooperation local engineering companies software developers paper presents learning materials advantages students academics
published concurrent data structures avoid provide fairness guarantees allow processes access data structure complete operations arbitrarily many times trying process complete single operation behavior prevented fairness however fairness requires waiting helping helping techniques often complex memory consuming furthermore known possible automatically transform every data structure non blocking implementation corresponding data structure addition satisfies weak fairness requirement mean fairness best use answer negative show possible automatically transfer non blocking wait free data structure similar data structure satisfies strong fairness requirement without using limited waiting fairness require process initiate complete two operations given resource process kept waiting resource approach allows many processes possible access shared resource time long fairness preserved achieve goal introduce solve new synchronization problem called fair synchronization solving new problem enables add fairness existing implementations concurrent data structures transform solution mutual exclusion problem fair solution elsevier inc rights reserved
background efficacious medicine smoking cessation little known characteristics users study examined characteristics first time naive users finland compared previously used pharmacotherapy trying pharmacotherapy first time methods cross sectional survey conducted finnish community february january pharmacy customers package first time ever asked complete questionnaire participate structured interview conducted pharmacist identical questions questionnaire included questions demographic characteristics smoking habits previous cessation attempts factors associated use results altogether people completed survey majority daily smokers history years regular smoking strong strong nicotine dependence half participants trying pharmacotherapy first time demographic characteristics smoking habits similar first time previous users medications health centers occupational health care clinics common sources prescriptions majority participants received prescription desire quitting physician conclusions considering relatively large proportion naive medicine users among new users smokers previously quit smoking use pharmacological interventions perhaps unaware options interested attempting cessation participants made initiative discuss smoking physician led prescribing suggests physicians satisfactorily recognize patients nicotine dependence desire quit actively support patients smoking cessation
hydrodynamic parameters identified firstly predicting soil water loss specific issues objectives laboratory simulation experiments conducted different gravel contents flow discharges slopes based field investigation achieved suitable parameter predicting soil water loss simulation slope earthquake area china results showed gravel content always threshold controlled flow shear stress tau stream power omega increased decreased different flow discharges unit stream power unit flow energy decreased gravel contents increased ratio coefficient flow depth higher fine sediments without flow discharge consistent effects hydrodynamics ordered min tau suitable parameter predicting soil water loss considering degree reliability even though omega also significant positive power function soil water loss describe hydrodynamics soil water loss alternative parameter predicting soil water loss results provide useful information soil water loss prediction deposits
investigate strong wind turbine tower model plane turbine blades comprises control laboratory experiment system two mass drive train model control input torque created electrical generator using strong theorem class impedance passive linear systems bounded control observation operators show wind turbine tower model strongly control static output feedback angular velocities generator rotor
paper reviews form historical perspective various methods treating simulating turbulence effects hydraulic flows highlighting main characteristic features turbulence role plays hydraulics necessarily brief overview given main methods used hydraulic flow calculations dealing turbulence effects empirical relations methods solving reynolds averaged navier stokes equations aid statistical turbulence models direct numerical simulations large eddy simulations les brief comments made historical development different methods les methods application examples presented details individual methods application examples reader directed extensive literature
paper deals algorithm optimize efficiency induction motors used battery electric hybrid vehicles concepts necessary design electric drives high efficiency order maximize driving range performance algorithm part holistic design process presented shown efficiency maps generated created way different control strategies influence drive efficiency therefore efficiency analyses two different induction machines field oriented rotor frequency control presented compared
biological systems formation molecular complexes cellular processes traditionally functional experimentation targeted single molecular players order understand effects cell animal phenotype last years experiencing rapid progress development ground breaking molecular biology tools affect metabolic structural morphological genetic instructions cells chemical optical mechanical inputs precise dissection cellular processes essential better understanding biological systems also allow better diagnose fix common dysfunctions present several emerging innovative techniques providing reader examples tools implemented cells cases organisms unravel molecular processes minute detail also discuss advantages disadvantages particular focus translation organisms vivo spatiotemporal regulation developments tools help solve processes life give rise novel clinical industrial applications
demand infrared transmitting materials grown steadily several decades markets realize new applications longer wavelength sensing imaging growth come demand new challenging material requirements satisfied crystalline products alone materials unique physical thermal optical properties found acceptance designers meet demands material perfect every regard exception cause concern relatively low fracture toughness propensity bulk material fracture condition amplified traditional manufacturing processes employed form processing leaves behind micro fractures sub surface damage act propagation points local catastrophic failure material precision lens process result micro fractures sub surface damage created results stronger component one produced traditional methods new processing methods also identified result even stronger surface resistant without need post processing techniques compromise surface integrity paper discuss results achieved process lens development optics result stronger components various metrics examined data presented quantifies component strength different manufacturing limb ischemia one common peripheral arterial disease surgical restoration blood flow often results ischemia injury previous study revealed inflammation intensity arterial tissue characterized expression high mobility group box protein contrary fluctuation limbs rat model study meant clarify role process laser doppler perfusion imaging evaluated limb mean max perfusion unit femoral arterial tissue collected molecular biology examination results revealed promoted vascular structure remodeling dysfunction acute characterized degradation fibers disruption elastic intensive inflammation phenotype transfer smooth muscle cells blockade preserved vascular homeostasis improved elevated expression tnf alpha mmp mmp alpha actin correlated positively conclusion promoted vascular remodeling dysfunction via initiating inflammation cascade blockade preserve vascular homeostasis facilitate blood perfusion ischemic limb elsevier inc rights reserved
stream experience memory system rapidly transforms current inputs long lasting meaningful memories putative neural mechanism strongly influences input elements transformed meaningful memory codes relies ability integrate existing structures knowledge schemas however yet clear whether schema related integration neural mechanisms occur online encoding current investigation examined encoding dependent nature phenomenon humans showed actively integrating words congruent semantic information provided category cue enhances memory words increases false recall memory effect active integration congruent information robust even interference task occurring right encoding word list addition via electroencephalography show separate studies onset neural signals successful encoding appeared early similar encoding congruent words neural signals successful encoding congruent incongruent information followed similarly similar later suggests earlier neural response contributed memory formation propose encoding events congruent readily available contextual semantics trigger accelerated onset neural mechanisms supporting integration semantic information event input faster onset result long lasting meaningful memory trace event time make difficult distinguish plausible never encoded events related false memories
brain stimulation nucleus improves motor symptoms advanced parkinsons disease also affect emotion possibly impacting parallel limbic striatal circuit objective study investigate changes prefrontal cortical activity related emotion induction task materials methodswe used near infrared spectroscopy monitor prefrontal cortex hemodynamic changes emotion induction task seven patients tested sequentially stimulation stimulation states dopaminergic medication patients watched series positive negative neutral videos general linear model used compare prefrontal hemoglobin concentration states brain stimulation correlated prefrontal hemoglobin changes relative stimulation state response positive negative videos changes specific emotional stimuli seen neutral stimuli results suggest stimulation influences prefrontal cortical representation positive negative emotion induction
paper presents linear programming model solution time cost tradeoff problem although several analytical models developed time cost optimization many mainly focused projects contract duration fixed optimization objective therefore restricted identify minimum total cost another group primarily focused project duration minimization model presented considers scheduling characteristics ignored prior research new formulation variability funding uncertainty project duration considered together chance constrained programming used incorporate variability funding quantified coefficient variation financial feasibility expressed stochastic constraint transformed deterministic equivalent confidence level also project duration uncertainty incorporated model applying program evaluation review technique scheduling uncertainty quantified coefficient variation confidence level system objective function minimizing direct cost group constraints solved using software two examples conducted demonstrate models performance contributions four scenarios adopted solving example problems reflect effect funding variability time uncertainty project cost duration results revealed confidence level variability funding versus increase direct cost approximately project also variability time versus increase duration range approximately direct cost hand considering variability funding time increase direct cost project time increase project duration occur direct cost
ability control engineering process execution vital importance success engineering project thus many studies focusing knowledge practices systems engineering processes proposed former work complete solution system process engineering problem starting engineering process models process execution control one main components solution scheduling engine able reach balance time consumption respective interest resource implemented solution context real life case study noticed inability provide high quality schedules available resources severely reduced limitation due fact scheduling engine limited using available resources given input absolute constraint paper provide solution problem additional resources cost optimization context work strongly linked former publications conveniently cited paper completion original solution see end paper considered context case study order review execution results
paper presents new driving method sulfur plasma lamp low power applications newly developed power supply series resonance type full bridge topology controlled phase shift track beam current drive sulfur plasma lamp optimally provide peak power discharge condition sulfur plasma lamp allow average power control light satisfying condition newly developed driving method uses burst mode enables peak average power controls satisfy conditions furthermore current offset developed guarantees zero voltage switching field effect transistors although operates burst mode thus proposed method provides easy lighting optimized conditions high efficiency power delivered proposed method reached variable average power similar adjusting burst time experimental results proved feasibility proposed driving method
objective study aimed investigate whether negative impact result psoriatic arthritis disease inner ear function methods twenty four successive patients healthy volunteers younger years age followed least one year outpatient clinics physical therapy rehabilitation diagnosis psa according criteria hearing impairment included study distortion product emission values khz khz examination results reflex values speech reception threshold speech discrimination values pure tone values high frequency values analyzed statistical comparisons groups performed using chi square test mann whitney test accepted level statistical significance results study population consisted male female patients mean age range years male female healthy volunteers mean age range years control group mean duration arthritis years evaluation hearing frequencies patients statistically significant difference found relative control group values patients analyzed within interval compared control group statistically significant difference found conclusion study provides strong evidence suggesting necessity patients regarding hearing loss take measures development hearing loss early stage another disability patients psa potential cause severe disability elsevier ireland ltd rights reserved
accumulating evidence suggests long noncoding rnas crucial regulators epithelial mesenchymal transition emt tgf beta signaling major inducer emt facilitate lung cancer metastasis however role process remains largely unknown identified differentially expressed lung cancer tissues compared adjacent normal tissues gene body vicinity transcripts also bound expression significantly decreased cells treated tgf beta furthermore stably regulated lung cancer tissues compared normal tissues data sets another published lung cancer data sets bioinformatics analysis suggested associated tgf beta participate emt process moreover promoted cell migration invasion whereas overexpression prevented cell metastasis importantly expression regulated affected several emt markers expression findings suggest mediator tgf beta signaling play significant role regulation emt lung cancer cell migration invasion elsevier rights reserved
twenty two novel substituted ethanol derivatives synthesized evaluated antiviral activities hcv taking compound lead sar study indicated shortening butyl chain ethyl chain affect activity significantly target compounds ethanol demonstrated potential anti hcv effect value value free hydroxyl arm made possible parent structure prepare pro drug potential application hcv treatment study provided powerful information strategic optimization development kind compounds novel family anti hcv agents elsevier ltd rights reserved
objective although growing body evidence suggests culture change care improves resident outcomes nursing home setting little known effect culture change setting patients receive skilled nursing rehabilitation services relatively short period time returning home design data study collected part larger project understand impact veterans health administration policies shift mission community living centers long stay care short stay skilled nursing care results although qualitative data collected interviews site visits eight geographically diverse suggest increase quality life care veterans interview data also indicate unintended consequence specifically staff described aspects environment relationship based care delivery attention veterans preferences characterize culture change prolong veterans length stay beyond treatment completion addition providing skilled nursing rehabilitation also serve latent function providing comfortable home peer community veterans connect one another living environment persons shared symbolic status unique strong bonding among peers staff staff respect veterans service country increase sense keep veterans past expected discharge date conclusion findings suggest complexities culture change centered care short term care setting discuss findings also relevant non sector society post acute long term care medicine
several newly synthesized including studied corrosion inhibitors mild steel weight loss measurements electrochemical experiments quantum chemical calculations experimental results show compounds high inhibition efficiency order concentration showed highest inhibition efficiency adsorption inhibitors metal surface langmuir isotherm basic adsorption mechanism proposed based quantum chemical calculations
novel series urea derivatives synthesized evaluated potential inhibit enzyme among reported compounds compound emerged potent compound value induced lipoprotein lipase inhibition model compound reduced triglyceride turnover vivo compound also showed dose dependent prevention serum total cholesterol prevention ldl elevation dose furthermore compound showed potential stop falling levels serum hdl dose dependently improved index effect body weight plaque formation development lesions studied toxicological study compound indicated dose devoid signs toxicity mortality elsevier masson sas rights reserved
objective providing patient centered care requires consideration numerous factors making decisions influence patients health status background clinical decisions informed relevant research evidence literature often lacks pertinent information problems encountered routine clinical practice although randomized clinical trial provides best research design ensure internal validity study findings ethical considerations competitive culture sport often random assignment patients participants control condition clinical advantages cohort study design bayesian approach data analysis provide valuable evidence support clinical decisions classification outcome predictive factors permits quantification likelihood occurrence specified outcome conclusions multifactorial prediction models reduce uncertainty clinical decision making facilitate treatment thereby supporting delivery clinical services evidence based patient centered
business process one main problems consists organizational employee new instruments automatic identification stakeholders among existing staff evaluation needed difficult identify stakeholder especially refer science stakeholders proper evaluation researchers value position international level needed large concerning validity various types indexing services techniques used classify researchers paper proposes use corporate human resource management specific instruments comes researcher informational stakeholder identification main idea behind method use form information retrieval techniques set research papers contain mostly key words extract hierarchy researchers involved referenced set distributed approach used due inherent scalability use inference engine also deemed necessary due complexity problem system used automatic assessment research performance public private institutions easily modified support complex sets rules depending users needs personnel evaluation main research field papers concerns distributed artificial intelligence elsevier ltd rights reserved
tree significant mobile satellite radio propagation investigation known successful link design therefore limited data relevant problem purpose propagation measurements band performed turkey respectively experiments executed transmitter top high building receiver system located van antenna roof receiver equipment interior measurements carried different tree types results bands presented graphical forms experiments repeated trees months april september variations tree attenuation examined months without average values tree found band respectively scaling factor band determined approximately using measured parameters depth statistics calculated using model establish validity obtained results design mobile satellite links results compared previous investigations
introduction limited evaluation clinical theoretical claims sexual thoughts children others facilitate sexual offending nature thoughts contain also unknown aim examine relation child sexual thoughts sexual offending determine nature thoughts differences among sexual offending non sexual offending non offending men methods cross sectional computerized survey anonymous qualitative quantitative self reported sexual thought experience data collected adult volunteers equal numbers men recruited medium security prison community sample men main outcome measures computerized interview sexual thoughts computerized inventory sexual experiences results three analytical approaches found child sexual thoughts related sexual offending sexual thoughts themes latent class analyses identified three types child sexual thought primarily differentiated interpersonal context reporting emotions emotions others four types sexual thoughts others discriminated persons response emotional states reported consent non consent mixed type child sexual thought participant group significantly related type sexual thought group marginally related type common group non type common group expected statistically conclusion child sexual thoughts risk factor sexual offending assessed clinicians general sexual thoughts themes risk factor although thought type important thoughts person expresses enduring lack consent exploring dynamic risk factors associated type child thought lead targeted treatment copyright international society sexual medicine published elsevier inc rights reserved
three hundred forty two university students completed short dark inventory inconsistent showed higher psychopathy scores consistent differences observed participants subdivided quartile low moderately low moderately high high psychopathy groups non clinical absolute scores equally distributed among low moderate groups significantly lower high psychopathy group findings suggest inconsistent associated upper quartile psychopathy scores also males showed significantly higher psychopathy scores females ratio male female inconsistent decreased psychopathy score increased interaction indicated female male inconsistent higher psychopathy scores consistent although significant effects small participants range potential clinical diagnosis reader therefore strongly inconsistent psychopathy
plants require addition removal energy process movement material within process vessels fundamental mass energy transfer requirements typically achieved use process utilities include electricity steam fuel gas cooling water compressed air utilities responsible significant portion operating cost plant therefore reduction consumption utilities common process optimisation area situation different comes generation transportation utilities often overlooked regard optimisation paper potential benefits utility optimisation illustrated particular focus generation transportation areas main objectives reductions electrical energy consumption cost illustrated dual circuit cooling water system system non linear also hybrid sense contains continuous discrete input variables significantly design implementation control optimisation solutions paper illustrates cost energy consumption hybrid system reduced implementation hybrid non linear model predictive control economic results compared base case advanced regulatory control arc case showing significant additional benefit achieved implementation advanced control optimisation techniques paper illustrates additional capital necessarily required implementation techniques elsevier ltd rights reserved
forensic analyses embedded cyber physical systems tedious manual processes commonly designed support additionally physics impact embedded cyber physical system formal methodologies currently art chapter describes novel testbed design methodology integrates embedded industrial control systems physics simulators thereby supporting forensic analyses embedded cyber physical systems without risks unlike existing hardware based resulting soft industrial control system portable design however embedded system virtualization non trivial especially level solutions vary widely depending embedded system architectures operating systems chapter discusses proposed methodology overcomes challenges embedded systems explores benefits via proof concept implementation involving variable step voltage regulator control panel
security issues still unique design characteristics additional impact system network security potential impact policies procedures address key feature protocol stack allow hosts generate addresses using information hosts information duplicate address detection process part address used check addresses generated already configured nevertheless design process vulnerable denial service attack leaving hosts example host neighbor temporary address causing host consider duplicate eventually reject address various mechanisms send introduced address attacks techniques effective still possibilities attacks carried new mechanism needed effectively prevent attacks process paper present detailed design development novel mechanism address existing prevention techniques
role superior temporal gyrus auditory processing language comprehension self monitoring study aimed investigate relationship cortical thickness positive symptom severity schizophrenia prospective meta analysis includes data individuals schizophrenia collected seventeen centres around world contribute schizophrenia working group thickness measures extracted weighted brain scans using study performed meta analysis effect sizes across sites generated model predicting left right thickness positive symptom severity score positive scores controlling age sex site secondary models investigated relationships antipsychotic medication duration illness overall illness severity thickness symptom severity negatively related thickness left right statistically controlling age sex site effect remained stable models including duration illness antipsychotic medication findings underline important role hallmark symptoms schizophrenia findings assist advancing insight symptom relevant pathophysiological mechanisms schizophrenia
research quantifies rate volume oil gas released two natural sites mexico blocks depth depth objectives determine variability release rates bubble size five individual investigate effects tidal fluctuations bubble release observations autonomous video cameras captured formation individual released partially exposed deposits gas image processing techniques determined bubble type gaseous mixed gaseous size distribution release rate temporal variations observation intervals ranged bubble counting algorithm developed analyze bubble count release rates video data method suitable discrete small bubble streams commonly seen adaptable multiple situ set ups two analyzed released average diameter rate respectively approximately away within site two analyzed released mixture gaseous average diameter rate respectively fifth released gaseous average diameter rate pressure records showed diurnal tidal cycle demonstrated positive correlation diurnal tidal cycle however observations conclusive regarding tidal effects bubble release elsevier ltd rights reserved
recently introduced concept color transfer visual cryptographic scheme embedding information color channels conventional als visually secret image shadow images similar conventional obtained high quality color image however als requires key encoding decoding phases therefore strictly speaking threshold scheme perfect security study solved security problem proposed require key experiment indicated proposed solution achieves feature obtaining original color image als addition formally defined contrast security conditions demonstrated constructions satisfied contrast security conditions elsevier ltd rights reserved
address force law classical material media paying attention force term due time variation hidden momentum magnetic highlight emergence force component required general theorem deriving zero total momentum static configuration charges currents time disclose add force term lorentz force law material media show adoption force law resolve issue small electric magnetic density force integrates exactly equation like lorentz force inclusion hidden momentum contribution thus none available expressions force moving compatible transformation force support statement number particular examples respect suggest applying lagrangian approach derivation force law polarized medium framework approach obtain novel expression force small electric magnetic novel expression generalized momentum latter expression implies two novel quantum effects non topological phases electric moving electric field magnetic moving magnetic field phases general related dynamical effects equal zero classical force implications obtained results discussed elsevier inc rights reserved
little leaf widespread disease etiology india induces severe economic losses surveys conducted eight states india july september eighteen samples showing little leaf symptoms collected identification presence confirmed eighteen samples using polymerase chain reaction specific primer pairs pair wise sequence comparison phylogenetic relationship rrna gene sequences strains confirmed sixteen eighteen strains belonged proliferation group two strains classified group virtual rflp analysis rdna sequences allowed classification strains subgroups strains belonging subgroup found widespread strains associated disease india subgroup association two symptomatic species viz cannabis sativa sativa fields new also confirmed nested pcr assays similar set specific primers pairwise rdna sequence comparison phylogeny virtual rflp analysis five identified species infected fields identified carrier natural vector subgroup nested pcr assays sequence comparison phylogeny virtual rflp analysis transmission assays
reservoir simulations always involve large number parameters characterize properties formation fluid many subject uncertainties owing spatial heterogeneity insufficient measurements provide solutions uncertainty related issues reservoir simulations general package called developed includes three main functions required full stochastic analysis petroleum engineering generation random parameter fields predictive uncertainty automatic history matching developed manner non intrusive package integrated existing commercial simulator petroleum engineering facilitate application computational efficiency improved theoretically introducing surrogate model based probabilistic method technically using parallel computing series synthetic cases designed demonstrate capability test results show random parameter field flexibly generated customized manner petroleum engineering applications predictive uncertainty reasonably quantified computational efficiency significantly improved ensemble kalman filter based automatic history matching method improve predictive accuracy reduce corresponding predictive uncertainty accounting observations
great made advance understanding neurobiology suicidal behavior neural neuropsychological mechanisms associated understood purpose current study identify neurocognitive markers context medical rehabilitation performances patients medical rehabilitation center aged examined series neurocognitive executive tasks decision making gambling task mental flexibility response inhibition working memory digit span self report questionnaires administered suicidal behaviors depression anxiety ptsd perceived social support suicidal participants performed poorly mediation analysis presented significant direct effect decision making suicidal risk significant indirect effect decision making suicidal risk mediated depressive symptoms medium effect size despite complexity relationship decision making suicidal risk results suggest clinicians routinely assess decision making abilities adults risk suicide due fact impaired decision making increase suicidal risk beyond conferred depression
paper proposes cascaded control structure method practical application attitude control multi rotor unmanned aerial vehicle uav cascade control control capability single loop control rarely used attitude control multi rotor uav due input output relation longer simply set point euler angle response transfer function single loop pid control measured signals interactive control loops increase complexity evaluation conventional way design however proposed research method optimize cascade control primary secondary loops pid controller loop investigation currently available pid tuning methods lead selection simple internal model control method based internal model control direct synthesis method analysis experiments research proposes systematic procedure implement cascaded attitude controller includes flight test system identification based pid tuning proposed method validated successfully multiple applications application roll axis lead pid pid cascade control application axis lead pid
abuse related trauma remains global health issue however paucity nationwide reports aim estimate incidence abuse related trauma forward medical care identify characteristics clinical course taiwan patients trauma occurred months diagnosis abuse identified randomly sampled nationwide longitudinal health insurance database million beneficiaries patients demographic data injury pattern medical resource utilization measured stratified age sex compared using chi square test risk factors next trauma event identified using cox regression analysis ninety three patients females identified mean age years including years age first trauma event patients visited emergency room received intervention needed hospital care seven less years old intracranial hemorrhage required intensive care thirty three left complications sequelae required rehabilitation survived victims sexual abuse aged less years men received mood antipsychotics psychotherapy risk factors next trauma event injury involving extremities hazard ratio use antibiotics first trauma event abuse related trauma heterogeneous presentations among subgroups clinicians alert providing timely diagnosis individualized intervention
background study aimed investigate efficacy safety nasal products tube functional endoscopic sinus surgery chronic patients china material methods sixty six patients undergoing surgery randomly divided groups patients group tube group group group postoperative headache nasal pain nasal bleeding swelling nasal mucosa observed month surgery chronic conducted removed nasal results vas scores nasal pain tube group lower groups volume nasal bleeding group higher tube groups adhesion rate nasal cavity group also higher tube group group results bacterial culture removed nasal showed negative cns frequent tube group groups streptococcus pneumonia influenza gram negative common group tube groups conclusions results indicate tube effective safe nasal surgery
software project encounters many changes software development life cycle key challenge control changes manage impact project plan budget implementation schedules developed change control process assist project manager responsible team monitoring changes paper examine number approaches project monitoring control different scenarios project schedules comparison shows effect applying approach cost time project evaluation illustrates integrated software project change management efficient providing control tracking change requests improve performance monitoring process
family large family transcription factors found higher plants plays central roles many aspects biological processes environment however little information available family apple present study total candidate genes apple genome identified classified three main groups group iii based structure conserved domains group subgroup showed similar exon intron structures motif compositions evolution analysis showed genes clustered intensive regions formed pairs relationships suggesting tandem played important role evolution diversification gene family apple furthermore expression genes apple leaves response biotic stress alternate hormone treatments acid methyl examined using rna seq qrt pcr results showed genes differential expression transcript abundance response apple infection moreover pathogen responsive genes also changed significantly apple leaves treated plant growth regulations suggesting interaction ethylene hormone signaling biotic stress work provide basis future studies genetic modification genes pathogen resistance apple
trees outside forests tof represent source biomass received increasing attention recent years studies already investigated potential tof germany spatial explicit analysis specifically still lacking used unique wall wall airborne light detection ranging lidar dataset combined data map classify tof federal state similar south western germany furthermore annual biomass potentials tof areas collected available literature calculated mean annual biomass supply tof areas combination remote sensing based classification available literature resulted mean annual biomass supply similar tof classification three reference sites high similar using simple filter technique applied lidar data man made objects using data contrast available literature revealed high variability biomass potentials supporting demand inventory system still results demonstrate applicability lidar based vegetation mapping value data detect man made objects elsevier rights reserved
impulsivity widely related socially problematic behaviors psychiatric illness previous studies investigated relationship response inhibition impulsivity however study intensively examined impulsivity correlates automatic sensory processing drive response inhibition sensory inputs sensory gating automatic inhibitory function attenuates neural response redundant sensory information protects higher cognitive functions burst information processing although functions abnormally several clinical populations little evidence supporting changes conjunction impulsivity traits non clinical populations present study recruited healthy adults conduct neurophysiological experiment using paired paradigm self report scales assessing impulsive behavioral traits auditory stimuli included pure tone also white noise explore differences auditory evoked potential responses two stimuli white noise affective pure therefore predicted white noise correlate self reported impulsivity pure main findings showed amplitudes significantly correlated self reported reward responsiveness seeking respectively white noise stimuli demonstrating higher scoring impulsivity related greater frequency domain analyses also revealed greater beta band second white noise stimulus associated higher motor impulsivity scores suggesting impulsivity related change associated attentional modulation findings indicate measurement white noise efficient tool evaluate impulsivity non clinical populations also applied clinical populations
building fractional mathematical models specific phenomena developing numerical analytical solutions fractional mathematical models crucial issues mathematics physics engineering work new analytical technique constructing predicting solitary pattern solutions time fractional dispersive partial differential equations proposed based generalized series formula residual error function new approach provides solutions form rapidly convergent series easily components using symbolic computation software method evaluation validation proposed technique applied three different models compared known methods resultant simulations clearly demonstrate superiority proposed technique terms quality performance accuracy preservation construct prediction solitary pattern solutions time fractional dispersive partial differential equations elsevier inc rights reserved
data evolution critical problem present scenario due transactions change structure arising evolving users requirements handling properly type changes crucial process forms core component modern therefore updated periodically according different type evolution information sources problem evolving appropriate set views subjected view evolution problem many different view evolution methods proposed literature address issue paper provides survey view evolution methods paper aims studying view evolution relational databases data distributed setting defines evolutionary approach highlighting view evolution problem identifying three main dimensions basis classification view evolution methods namely framework architecture iii model design model study reviews architecture based view evolution methods identifying respective potentials limits authors published elsevier
quantitative susceptibility mapping increasingly used measure variation tissue composition brain areas body range disease pathologies although measurements originally believed independent echo time used gradient recalled echo acquisition derived recent literature shown measurements highly dependent number brain regions work systematically investigate possible causes effect analysis apparent frequency measurements derived data acquired multiple vivo healthy brain regions cerebral data acquired doped phantom data derived simulated phase data apparent frequency measurements optic central corpus compared predicted pool white matter model however model failed fully explain contrasting frequency profiles measured results show dependent measurements caused failure phase algorithms around strong susceptibility sources however healthy brain regions behavior appears result intrinsic non linear phase evolution signal results conclude care taken deriving frequency measurements strong susceptibility sources due inherent limitations phase signal due tissue microstructure content plausible cause dependent frequency measurements healthy brain regions better sampling signal complex models tissue needed fully exploit relationship
background purpose paper describe variation months year major depressive episode prevalence important aspect epidemiological description one received surprisingly little attention literature evidence seasonal variation prevalence weak contradictory studies sought estimate prevalence seasonal affective disorder using cut points applied scales assessing mood seasonality rather approach align modern classification seasonal depression diagnostic subtype major depression rather distinct category also studies lacked power detect seasonal differences addressed limitations examining month specific occurrence conventionally defined data large epidemiological surveys enhance precision analysis method data two national survey programmes national population health survey canadian community health survey used providing ten datasets collected together including studies assessed using short form version composite international diagnostic interview major depression one exception survey used non version proportion episodes occurring month evaluated using items diagnostic modules statistical methods addressing complex design features trials overall month specific pooled estimates associated confidence intervals estimated using random effects meta analysis gradient assessed using meta regression model included quadratic term results considerable sampling variability month specific proportions estimated individual survey datasets however across various datasets sufficient homogeneity justify estimated proportions producing large gains precision seasonal variation clearly evident pooled data highest proportion episodes occurred december january february lowest proportions occurred june july august proportion respondents reporting january higher august suggesting association implications health policy pattern persisted stratification age group sex latitude conclusions seasonal effects small sample sizes prior studies canada clear seasonal variation yet addressed planning services results suggest availability depression treatment higher winter summer months
two studies provided evidence decision report ambiguous case child abuse affected subsequent memory case information participants recognized details presented original information associated child abuse moreover post decision information child later died abuse influenced memory reports participants chosen report case increasing reports false schema consistent details suggests false decision consistent memories primarily due sense making processing rather motivation justify decision present findings points important mechanism decision information become distorted emphasize difficulties improving future decision making past decisions results also indicate decisions generate false memories apparent absence external suggestion misleading information implications decision making theory applied practices discussed
purpose review purpose review examine relationship headaches epilepsy headaches non seizures emphasis placed clinical characteristics pathophysiology treatment recent findings epilepsy headaches common disorders occur often expected chance overlapping clinical features migraine epilepsy evidence shared underlying mechanisms proposed theories shared etiology include ion channel dysfunction glutamatergic mechanisms mitochondrial dysfunction recent diagnostic classification systems recognized relationship headaches epilepsy headaches rare raise suspicion headaches patients epilepsy despite evidence efficacy headache medications summary comorbid headaches epilepsy relatively common population presenting patients headaches epilepsy receive appropriate treatment often includes mutually beneficial preventative therapy includes headache treatment
home environment influence childhood allergies respiratory health little information associations early life exposure home new onset remission asthmatic allergic symptoms preschool children questionnaire survey performed random cluster sample preschool children china information home environment perceptions indicators pollution sources childrens health rhinitis eczema collected first years life last year answering questionnaire one parents another child associations home environment first years life new onset remission childhood symptoms analyzed multiple logistic regression home environment factors reported first years life consistently positively associated new onset symptoms negatively associated remission symptoms visible air parental smoking associated new onset symptoms factors negatively associated remission symptoms conclusion contamination home visible poor indoor air quality air exposure environmental tobacco smoke first years life increase incidence asthmatic allergic symptoms decrease remission symptoms preschool children rights reserved
knowledge autumn response climate variability currently limited one way improve understanding autumn landscape scale investigate autumn vegetation dynamics based multiple vegetation indices remote sensing data study derived two autumn metrics onset drying semi arid modis normalized difference water index time series onset drying represents start decline metabolism autumn onset based end metabolic activity based compared enhanced vegetation index based northeastern china influences climatic variability autumn analyzed using partial correlation analysis found general onset drying slightly later onset based senescence strongly correlate precipitation mean minimum temperature august onset based average time lag seven days relative onset based moreover showed much stronger response mean minimum temperature september based autumn generally advanced onset based little effect onset based study area results suggest studies using expand understanding land surface furthermore considering different responses onset based climate variability combination contribute study ecosystem processes carbon cycle semi arid elsevier rights reserved
wireless sensor networks wsns consists large number spatially distributed configurable sensors meet requirements industrial military precision agriculture health monitoring applications ease implementation maintenance cost transmission data requires energy quality service qos aware routing ensure efficient use sensors effective access gathered information design wsns considering issues challenging task leads complex algorithm design difficult analyze analytical methods physical measurements deploying test beds huge effort computer aided simulation feasible approach analysis wsns addressed different types simulators along key features applicability simulation numerous application areas
recognition texts scenes one important tasks many computer vision applications though different scene text recognition techniques developed scene text recognition generic condition still open challenging research problem one major factor advance research area character many characters scene images heavily segmented recognition paper proposed novel scene text recognition technique performs word level recognition without character segmentation proposed technique three advantages first converts word image sequential signal scene text recognition second recurrent neural network long short term memory technique widely used recognition recent years third integrating multiple accurate recognition system developed capable recognizing scene texts including heavily ones without character segmentation extensive experiments conducted number datasets including several robust reading datasets google street view dataset experiments show proposed technique capable recognizing texts scenes accurately
background biomass burning shown source poor indoor air quality developing higher income countries across world specifically wood burning cooking heating contributes high indoor concentrations fine particles aerodynamic diameters coarse particles aerodynamic diameters particulate matter predominantly found within coarse fraction airborne particulate matter associated proinflammatory effects adverse outcomes among susceptible populations aim study assess efficacy air filter interventions reducing indoor associated concentrations homes using wood primary heating results homes randomized receive filtration units either high efficiency filter active lower efficiency filter placebo active filter intervention showed reduction indoor concentrations reduction relative placebo intervention active placebo filters effective substantially reducing indoor concentrations average reduction active placebo filters respectively associated concentrations average reductions respectively conclusions findings support use high efficiency air filtration units reducing indoor homes using wood primary heating also discovered using lower efficiency lower cost filter alternatives effective reducing airborne homes burning biomass fuel published elsevier
propose approach designing implementing top existing systems without interfering detect errors fail uncontrolled systems controllers identify particular situations ambient intelligence ami systems formalism use representing expected patterns actions trace expressions extended features dealing paper provide syntax semantics extended trace expressions formalism examples use different contexts fail uncontrolled ami systems
gastrointestinal microbiota gut interacts host tissue contact zone layer understanding details interactions especially dynamics crucial identify active subset microbiome became possible development stable isotope probing techniques applied microbiome research applied vivo stable isotope approach using labeled diet subsequent identification active bacterial species four week old male sprague dawley rats randomly assigned diet high fat diet weeks three animals group sacrificed baseline characterization anthropometric metabolic obesity remaining animals exposed either labeled experimental diet three rats cohort sacrificed remaining three animals cohort received diet sacrificed colon harvested divided three equal sections proximal medial distal layer specimen sampled identified active subset model obesity comparison lean controls rats using addition samples investigated rrna gene sequencing active microbiome group showed increase bacterial taxa contrast significant changes alpha diversity time localization dependent effects beta diversity clearly observed terms enzymatic functions group showed strong affected metabolic pathways energy production carbohydrate metabolism vivo isotope labeling combined provides valuable method distinguish active non active bacterial phylogenetic groups relevant microbiota host interaction morbid obesity analysis provide potentially new strategies targeted pre probiotic treatments
currently exist many traditional pid proportional integral derivative controller tuning methods single objective optimization problems however dealing multi objective optimization problems traditional methods face many theoretical challenges furthermore situations even worse presence multi constraint requirements view situations applying heavy distribution sequences basic search algorithm firstly propose novel based pid controller tuning method multi objective multi constraint optimization problems proposed swarm intelligent optimization algorithm introduction sequences represents novel heavy search strategy order improve search performance thus terms achieving global optimization modified algorithm provide accurate pid parameter estimates simulation experiments verify proposed algorithm quite efficient institution chemical engineers published elsevier rights reserved
background many studies shown transition college negative effect students life style choices resulting weight gain increasing inactivity stress additionally issue recognised limited attempts targeted interventions aimed university student population establishment poor behavioural choices stage students life lead consistency unhealthy lifestyle practices ultimately placing students risk heart disease lifestyle related health issues problematic nursing students identified within public domain health promoters model least healthy lifestyle choices current intervention proposed possible mechanism process establish healthy lifestyle choices crucial time students life hope lifelong health benefits aim innovative study aimed evaluating effectiveness health module nursing students health methods teaching health new course university provided first year undergraduate students one university site republic ireland roi approximately half sample nursing students underwent intervention half served comparison group health behaviours groups compared using pre post test measures findings important finding study statistically significant increase psychological wellbeing intervention group corresponding decrease psychological comparison group findings also indicated initial significant increase physical activity intervention group although maintained time discussion targeted health behavioural interventions include stress management skills provided mandatory nursing students ensure health future professionals way role model behaviours required clients care elsevier ltd rights reserved
objectives exposure based cognitive behavioural therapy effective treatment anxiety disorders response varies individuals gene expression integrates genetic environmental influences analysed effect gene expression genetic markers separately together treatment adult participants diagnosed disorder specific underwent part standard care percentage decrease clinical global impression severity rating assessed across treatment baseline month follow associations treatment response assessed using expression data probes expression profiles clustered data literature driven manner total genetic variants used predict treatment response alone combined risk scores genotype expression data combined expression quantitative trait loci expression levels associated either treatment phenotype analysis total identified interactions genetic variants treatment response affect expression levels significantly genetic variants significantly predict treatment response alone risk assessed gene expression alone alongside genetic variants associations treatment outcome identified future studies require larger sample sizes discover associations
database technology affects many disciplines beyond computer science business paper describes two developed images color visually dynamically introduce fundamental relational database concepts querying students many goal educators diverse academic disciplines incorporate existing courses order meet pedagogical needs introduction assessed evaluated within several contexts including non courses offered computer scientists course computational molecular biology evaluation indicated student knowledge fundamental database concepts improved significantly use provide visual learners engaging method learn topics presented ability dynamic presentation overall evaluation indicates accessibility database topics across disciplines specific concepts need elaboration
new simulation based automated cmos analog circuit design method applies multi objective non type evolutionary algorithm based evolution model proposed article multi objective property automated design cmos analog circuits governed modified strength pareto evolutionary algorithm incorporated algorithm presented includes machine learning method decision trees makes distinction high low fitness areas design space learning process detect right directions evolution lead high steps evolution individuals learning phase evolution process makes remarkable reduction number individual evaluations expert designers knowledge circuit applied design process order reduce design space design time circuit evaluation made simulator order improve design accuracy cmos transistor model adopted proposed design method proposed design method tested three different operational amplifier circuits performance proposed design method verified comparing evolutionary strategy algorithm similar methods
background introduction direct acting considerably improved therapeutic outcomes patients chronic hepatitis virus hcv infections study aimed assess real world efficacy safety ribavirin treatment post transplant recurrence hcv infection material methods liver transplant recipients recurrent hcv genotype infection scheduled according therapeutic guidelines eligible primary efficacy endpoint sustained response weeks end treatment clinical laboratory adverse events aes recorded baseline results total patients included genotype infected treatment experienced fibrosis stage achieved patients including one patient genotype one patient detectable hcv rna end treatment two patients history first generation therapy two patients discontinued regimen aes experienced patients mostly mild death graft loss acute graft reported therapy treatment hepatic occurred three patients anemia observed patients requiring dose reduction discontinuation conclusions excellent efficacy post transplant recurrence hcv genotype infection treated real world conditions excellent outcomes observed irrespective prior treatment history degree fibrosis aes mostly mild transient
design prosthesis right hand whose dimensions weight allow adaptation children years adolescents presented finger two sections fusion middle distal proximal articulated hand palm angles movement extension flexion fingers except controlled link located drive system generates three degrees freedom based three linear actuators located palm led arduino microcontroller activated voice recognition system execute cylindrical functions precision grasp extended index finger based three linear actuators located palm reference provides position indication used microcontroller via input signal validate design stresses displacements analysis determination safety factor offers device selected materials carried using computer program based finite element method results obtained show light prosthetic device weights operate safely allowing four functions normal angles hand
coupled considered main source vibration rotating systems work mechanical system composed electric motor elastic coupling one stage gear investigated analyze dynamic behavior elastic coupling influence natural frequencies vibrations response system lumped parameter model corresponding system developed identify natural frequencies vibration modes addition distributions modal kinetic strain energies studied
effective cost strategies public insurance programs requires understanding distribution health care spending characteristics high cost aim characterize high cost states public insurance program determine whether expenditure inequality changes time changes cost sharing policies program eligibility use claims enrollment data childrens health insurance program children enrolled included study including multiple years enrollment months examine distribution costs time whether distribution changes increases cost sharing expanded eligibility patient characteristics predict high cost status examine health services used high cost children identify preventable top account total program costs inpatient outpatient costs largest components costs incurred high cost non urgent emergency department costs relatively small portion average expenditure increases time particularly expanded eligibility share costs incurred top increases slightly multivariable logistic regression results indicate infants older caucasian children chronic conditions likely high cost increased cost sharing reduce cost concentration average expenditure among high cost findings suggest identifying targeting potentially preventable costs among high cost called help reduce costs public insurance programs
background aims symptoms compatible irritable bowel syndrome ibs common patients inflammatory bowel disease ibd unclear whether relates ibd activity attempted resolve issue secondary care population using cross sectional study design methods analyzed rome iii ibs symptoms disease activity indices psychological quality life data consecutive adult patients ibd seen clinics university hospital united kingdom november june participants provided stool sample fecal analysis levels used define mucosal inflammation using symptom data levels identified distinct groups patients true ibs type symptoms ibs type symptoms levels regardless ibs symptom status compared characteristics groups results fifty seven patients crohns disease patients ulcerative colitis true ibs type symptoms levels psychological comorbidity significantly higher among patients true ibs type symptoms patients quiescent ibd inflammation quality life levels also significantly reduced compared patients quiescent disease inflammation similar patients active ibd using levels define mucosal inflammation found similar effect ibs type symptoms psychological health quality life conclusions cross sectional study identified distinct group patients ibd genuine ibs type symptoms absence mucosal inflammation symptoms negative effects psychological quality life degree active ibd new management strategies required patient group
since documented observations great debate diagnoses sub types diagnostic threshold relates now known autism spectrum disorder asd reflecting complicated history refinement dsm iii autism current dsm diagnosis disorder now widely accepted complex pervasive heterogeneous condition multiple etiologies sub types developmental trajectories diagnosis remains based observation atypical behaviors criteria persistent deficits social communication restricted repetitive patterns behavior review provides broad overview history prevalence etiology clinical presentation heterogeneity asd factors contributing heterogeneity including genetic variability comorbidity gender reviewed explore current evidence based pharmacological behavioral treatments asd highlight complexities conducting clinical trials evaluate therapeutic efficacy asd populations finally discuss potential new wave research examining objective biomarkers facilitate evaluation sub typing diagnosis treatment response asd
ubiquitous intracellular parasite strong brain tissue forms intracellular within neurons glial cells establishing chronic infection although latent generally assumed asymptomatic individuals now clear induce behavioral manipulations mice infected humans moreover strong relation emerged recent years psychiatric disorders link schizophrenia widely documented however significant association bipolar disorder suicidal aggressive behaviors also detected play role psychiatric disorders affecting neurotransmitters especially dopamine implicated emergence psychosis behavioral induced abnormalities inducing brain inflammation direct stimulation inflammatory cytokines central nervous system besides increasing evidence prominent role immune dysregulation psychosis aim review describe recent evidence suggesting link focusing interaction immune responses infectious agent psychiatric symptoms
regional level dimensionless analysis designing domestic rainwater harvesting system developed consider various combinations water demand storage capacity effective roof area rainfall design two dimensionless ratios used namely demand fraction storage fraction along relationship two ratios firstly northern taiwan divided four sub regions cluster analysis based average annual day rainfall distribution rainfall stations administrative districts easy use dimensionless curves demand fraction storage fraction obtained five rainwater supply four sub regions based dimensionless curves constructed designing rainwater supply reliability sub region storage capacities determined dimensionless curves showed close fit determined simulated values larger values estimated method presented green building evaluation manual situations methodology developed herein used effectively preliminary design overcoming difficulties faced designing without rainfall data incomplete rainfall data
observed childrens movements quite different adults performing action previous computer graphics research human motion primarily focused adult motion open questions different child motion actually whether differences actually impact animation interaction report first explicit study perception child motion ages years old compared analogous adult motion used motion capture collect exploratory corpus child adult motion conducted perceptual study point light displays discover whether naive viewers identify motion belonging child adult find people generally successful task work implications creating engaging realistic games online social media videos movies
broad spectrum antibacterial agent present active ingredient personal care products endocrine disrupting compound increasing presence water resources soils used farming potential fatty tissues toxicity aquatic organisms cause concern human environmental health also detected blood breast milk urine humans significance precisely understood data humans also lacking cell based studies however showed pro oxidant cytotoxic via number mechanisms oxidative phosphorylation appears prevailing toxicity mechanism though compounds role apoptosis cited known carcinogenic per vitro reported promote presence mice recent laboratory reports appear support view anti play significant role cancer progression results epidemiological studies effect human health implicated compound responsible certain allergies reproductive defects presence water also raises toxicity concern humans carcinogenic metabolites generated presence residual paper carried detailed overview pollution implications human environmental health
background nephropathy common cause syndrome adults many clinical cases reported associated hepatitis virus hcv infection antiviral therapy various case summary report case patient chronic hcv infection presented proteinuria treated sciences foster city found virus free conclusion reported case provide insight whether administered hcv related
theories linking literatures human resource management proposed individuals greater success obtaining jobs congruent stereotypes social categories traits explored effects detectable obvious social group distinction male sexual orientation bridging previous work prejudice occupational success social perception found perceivers rated gay straight men suited consistent stereotypes groups nurses pediatricians english teachers engineers managers surgeons math teachers mere photos faces notably distinct evaluations gay straight men emerged based perceptions faces explicit indication sexual orientation neither perceivers expertise decisions diagnostic information targets eliminated biases encouraging fair decisions contribute partly ameliorating differences mediation analysis showed perceptions targets sexual orientations facial affect accounted effects individuals therefore infer characteristics individuals group faces use information way influences evaluations suitability particular jobs
study investigated possibility reversed widely used enzyme reactor determination activity although rapid simple reversed limitations interference absorbing materials surfactant activity reversed determined reading absorbance lipid product conjugated among organic media effective acid reversed strong absorbance region major obstacle direct application reversed activity determination prevent interference added removal step procedure activity determination reversed activity dependent water content maximum activity obtained value elsevier ltd rights reserved
availability safe reliable water supply issue developing nations including india rainwater harvesting rwh site specific source control used satisfy human agricultural safety demands water study analyzed effects capturing rainwater year period jun provide three ecosystem services water supplementation indoor use water supplementation food production groundwater recharge hydrologic analysis completed using satellite rainfall data water balance approach two demand scenarios indoor outdoor considered water excess demand storage directed recharge groundwater economic analysis quantified rwh system net present value results indicated significant ecosystem services benefits possible rwh india rwh purpose providing irrigation small allowing concluded approach maximize benefits scenario provided greatest net present value fastest payback period years recharge groundwater rainfall benefit outdoor vegetable irrigation determined results showed caloric demands typical indian household met excess food offset capital cost system later economic gain
controversy exists regarding whether gastrointestinal issues play role symptomatology autism spectrum disorder asd studies found problems prevalent individuals asd others reported difference studies looking relationship issues asd symptom severity also mixed results current study examined participants age months participants comprised four groups children asd issues group asd problems group atypical development issues group atypical development issues group results current study suggest although prevalence symptoms higher participants asd without difference significant study also found issues related asd symptom severity developmental functioning
angioedema defined local self limiting edema owing increased leakage plasma located deep layers skin two mediators histamine bradykinin account cases angioedema angioedema occur manifestation urticaria form frequently allergic present review discuss angioedema without divided acquired hereditary forms histamine mediator acquired angioedema unknown etiology idiopathic acquired angioedema whereas forms main mediator caused inhibitor deficiency inh hereditary angioedema inh acquired angioedema mutations coagulation factor hereditary angioedema treatment angiotensin converting enzyme inhibitors acquired angioedema etiology remains unclear acquired angioedema idiopathic acquired angioedema type hereditary angioedema hereditary angioedema unknown origin several treatments licensed hereditary inh deficiency plasma derived recombinant bradykinin receptor blocker plasma inhibitor approved demand treatment reverse angioedema symptoms attenuated androgen plasma derived inh approved prophylaxis
purpose paper twofold develop sound complete rules along algorithms data structures construct network diagram road network compute attention focused distinguish paths others whose exactly border points research shows dominance relation introduced paper plays important role making distinction generate candidate paths concurrently border point binary tree introduced pre computed organized linked lists available access list based query search method compute single step experiments show method reduces execution time sparse data distribution real road network compared existing method query time remains nearly constant regardless data points distributed road network query point positioned addition approach prevents experiencing slow convergence condition often occurs using incremental approach elsevier rights reserved
trauma extremities disproportionately represented recent conflicts accounting injuries sustained operations infectious complications reported trauma patients treated intensive care unit icu reported intensive care unit patients deep wound infection type iii open tibia fractures infections extremity trauma frequently caused multidrug resistant bacteria demonstrated lead failure limb unplanned operative take late decreased likelihood returning duty invasive fungal infections extremities also presented unique challenge combat injured patients particularly blast injuries massive transfusion requirements high injury severity scores infection prevention begin time injury although context specific depending level care includes appropriate irrigation surgical wound care coverage fracture fixation antibiotic prophylaxis addition basic infection prevention measures clinical practice guidelines address infection prevention combat trauma including extremity infection developed revised endorsement surgical infection society infectious disease society america nevertheless significant challenges remain including environments care multiple transitions care lack coordinated efforts prevention treatment established infections optimally multidisciplinary particularly deep wounds bone joints involved surgical infected tissue necessary particularly aggressive margins invasive fungal infection suspected infected frequently requires use prosthetic materials fixation biofilm formation medical therapy antibiotic therapy targeted results deep wound bone cultures however complicated frequent contamination wounds requiring differentiation potential pathogens terms virulence decreased culture recovery patient frequently received previous antibiotics lessons learned infection prevention treatment orthopaedic trauma combat serve inform care patients injured natural disasters trauma
counting solution number optimization problems important topic study computational complexity concerned vertex cover paper first investigate organizations vertex cover solution spaces underlying connectivity vertices provide facts global local environment vertex cover solution number counting algorithm proposed complexity analysis provided results fit simulations better performance neighborhood random graphs based algorithm variation fluctuation solution number statistics studied reveal evolution mechanism solution numbers furthermore marginal probability distributions solution space investigated random graph scale free graph illustrate different evolution characteristics solution spaces thus solution number counting based graph expression solution space alternative meaningful way study hardness complete complete problems appropriate algorithm design help achieve better approximations solving optimization problems corresponding counting problems
epithelium derived factor neurotrophic factor neuroprotective anti anti angiogenic effects elevated levels previously proposed cerebrospinal fluid csf biomarker alzheimers disease however origin csf whether derived brain systemic circulation specificity finding hitherto remained unclear analyzed levels paired csf serum samples elisa patients alzheimers disease frontotemporal dementia vascular dementia bacterial multiple sclerosis diverse non inflammatory neurological diseases established csf serum quotient diagrams determine fraction synthesized csf found significantly increased csf patients bacterial remarkably concentrations also significantly elevated serum patients csf serum quotient diagrams demonstrated elevated concentrations csf patients mostly due elevated concentrations serum findings underscore importance relating concentrations proteins csf respective concentrations serum avoid erroneous interpretations increased protein concentrations lumbar csf elsevier rights reserved
health economic burden asthma united states substantial asthma self management education home based interventions asthma improve asthma control prevent asthma exacerbations interest health care public health collaboration regarding asthma increasing however outpatient home based asthma intervention programs widely available economic sustainability common concern thus conducted narrative review existing literature regarding economic outcomes outpatient home based intervention programs asthma united states identified outpatient programs home based intervention programs return investment roi data programs associated positive roi programs observed positive among selected populations higher health care utilization interpretation existing data limited heterogeneous roi calculations nevertheless literature suggests promise sustainable opportunities expand access outpatient home based asthma intervention programs united states definitive knowledge maximize program benefit sustainability gained controlled studies specific populations increased uniformity economic assessments published elsevier inc behalf american academy allergy asthma immunology
paper presents based control design ball beam system one sought problem control engineering students system comprises long beam moved using servo motor ball respect beam motion design estimation virtual state disturbance carried online state observer states used controller effects actual disturbances uncertainties plant designing controller simpler model used thus avoiding accurate modeling system nonlinear term unknown parameter plant considered internal external disturbance peculiar feature automatic disturbance rejection control based control scheme hence linearized model ball beam considered simulations carried help matlab simulink using algorithm controller shows good disturbance rejection capability shown simulation results ifac international federation automatic control hosting elsevier ltd rights reserved
style styles specific way expressing particular area human activity certain purposes communication based definition relating performance context decided conduct study communication style female players official game style communication sport environment called nonverbal communication target group consisted female players team plays first division national participated last seasons challenge study conducted competitive season consisted ways communication players game study aims highlight existence different style communication especially nonverbal communication represents starting point involved sports life beyond
positive memories powerful strategy repair affect positive memory recall operates strategy enhancing positive affect facilitates regulation negative affect individual differences however ability use positive material repair mood participants elevated depression scores example less likely profit strategy depression associated elevated fear positive emotion current study examined whether elevated fear positive emotion associated depression related difficulties mood repair ninety four participants first underwent mood repair task sad mood induction followed cue recall positive memories subjective measures state happiness sadness collected across mood induction positive memory recall procedures results revealed greater fear positive emotion linked less ability enhance positive affect regulate negative affect using positive memories results also provided preliminary support mediation model greater depressive symptoms predicted elevated fear positive emotion turn predicted less ability repair positive affect findings highlight fear positive emotion potential target interventions aimed improving affect regulation
serious games foster acquisition complex problem solving skills assessment skills line instruction within serious game environment content validity equal face face assessment research assessment serious gaming remained rather scarce article shows assessment implemented serious gaming way content validity core authors validation method entails mapping learning activities contained game scenario performance indicators outputs derived formal attainment levels present elaborated applied method assessment game ict managers secondary vocational education describe procedure extent assessment content valid compared face face assessment
people regularly take prosocial actions making individual greater good similarly people generally avoid causing harm others twin good avoid harm often align sometimes creating situations moral conflict examined moral conflict using modified game participants chose much money allocate away recipient designated creating sense harm money either participant people strongly prosocial allocated money away furthermore people left money harm framed means taking side effect splitting predicted dual process theories moral decision making response times longer take action positively correlated amount taken concluded just people take positive actions greater good similarly willing cause harm benefits others rather
aims self reported information questionnaires frequently used clinical epidemiological studies provide information reproducibility instruments applied secondary coronary prevention studies study aims assess test retest reproducibility questionnaire applied cross sectional norwegian coronary prevention study methods study coronary heart disease chd patients completed self report questionnaire consisting questions validated instruments novo questions test retest reliability instrument estimated four weeks consecutive coronary patients correlation coefficient icc kappa calculated results mean interval test retest days reproducibility values questions first part questionnaire differ latter good good reproducibility found lifestyle factors smoking exercise icc medical factors drug adherence icc sleep icc psychosocial factors anxiety depression icc quality life item short form health survey icc majority novo created variables covering patients perceptions motivation needs preferences conclusions present questionnaire demonstrates highly acceptable reproducibility key items instruments thus emerges valuable tool evaluating patient factors associated coronary risk factor control chd patients
aim previous studies reported outstanding amount injuries dominant mechanism results physical contact athletes therefore training program designed considering physiological stress competition athlete perform pad instead real order prevent injury competition methods twelve elite players selected ages years height weight max measured using exhaustive test min anaerobic power measured using field method heart rate alterations determined using scale competition three intervals periods round end third round blood lactate concentration evaluated competition evaluate ratio non activity digital video camera used simulation players performed motor skills simulating competition change blood lactate measured compared competition conditions data compared one way repeated measurement analysis variance anova results significant differences observed two conditions competition simulation training variables conclusion apparently simulation training physiological stress elite athletes replaced avoid possible sports injuries
urgent need identify signs onset borderline personality disorder bpd advancement area required refine developmental theories discover etiological mechanisms improve early detection achieve ultimate goal prevention though many studies supported wide range factors increase subsequent risk bpd literature yet critically evaluated comprehensive reviews examine integrate findings address limitation conducted systematic review summarize synthesize current literature electronic databases systematically searched prospective longitudinal studies examined risk factors subsequent bpd outcomes features symptoms diagnosis resulting total studies reflecting unique samples though increased risk bpd reliably attributed multiple factors within social family maltreatment child domains striking limitation research lack disorder specific findings additional limitations including notable heterogeneity sampling methodology symptom assessment methodology developmental timing assessments discussed terms close risk attempt provide future research
building integrated photovoltaic technology area recent development high potential implemented urban areas panels system serve structural elements required fixed optimum tilt angle maximum open fields model employed effectively calculating optimum tilt angle urban areas required consider adverse effect view blocking building accurate calculation optimum tilt angle determining maximum attempt calculate optimum tilt angle panel buildings different heights located different radial distances panel employing modified model present mathematical model gives accurate values accounts view blocking effects view blocking effect expressed factor calculated integrating trapped curve plotted given tilt angle panel optimum tilt angle panel presented different state capital india considering shadow effect surrounding buildings elsevier ltd rights reserved
autoimmune occurring association inflammatory bowel disease ibd rather rare carries worse prognosis greater disease severity compared ibd alone although documented association progress last years led better understanding association ibd ibd stronger association type type clinical histologic features ibd often reveal features type imaging helpful facilitating diagnosis ibd similarly attempts identify serological marker yielded better result proposed lymphocyte mechanism provides insight mechanism pathogenesis review represents update current knowledge association ibd
agricultural expansion main drivers land use change brazil soybean major crop expansion area soybean production involves large amounts water act sources contamination potentially negative impacts adjacent water bodies impacts intensified projected climate change tropical areas water footprint assessment serves tool assess environmental impacts water use aim study understand potential impacts environmental sustainability agricultural close protected forest area amazon climate change carried calculate water footprint related soybean production glycine max understand sustainability river basin region brazilian amazon large expansion soybean based global datasets environmental potentially areas identified spatially plotted baseline scenario projection use land use change scenario includes climate change effects results show green grey values increased respectively one third watersheds doubled grey soybean production lies within sustainability however current soybean expansion trends lead large impacts relation water pollution water use affecting protected areas areas impacted terms water pollution dropped whole catchment increased management practices water consumption regulations stimulate efficient water use reduction crop water use optimal application control key factors achieving sustainability river basin elsevier rights reserved
molecular dynamics simulations using combined quantum mechanical molecular mechanical potential carried investigate internal proton transfer equilibrium external species stabilization enzyme cofactor active site alanine solvent effects lower free energy aqueous solution active site resulting free energy difference mol relative base enzyme external provides dominant contribution lowering free energy barrier spontaneous water remarkable mol enzyme lowers barrier mol kinetic isotope effects also determined using path integral free energy perturbation theory primary secondary substitutions case alanine ring active site contribution formation alpha gas phase although ring contribution stabilizing aqueous solution alanine alpha stabilized ring computational studies illustrated article show combined simulations help provide deeper understanding mechanisms dependent enzymes article part special issue entitled phosphate enzymology published elsevier
electrical circuits beyond practical limits law common goal create carbon based components first example new class donor sigma acceptor possess donor acceptor moieties electronically isolated inter ring self template gold surface directed forming thick monolayer measured monolayer single molecules using three different top electrode arrangements even though composed relatively weak ratios ranging observed
using data family module east asian social survey article examines associations marital satisfaction gender ideology four east asian societies urban china japan south korea taiwan compared japanese korean married women men chinese taiwanese satisfied marriage simultaneously held less gender multivariate analyses showed relative share negatively associated marital satisfaction japanese korean men korean taiwanese women gender ideology significantly associated lower marital satisfaction among taiwanese women addition negative association marital satisfaction pronounced taiwanese women gender authors discuss differences macro level social contexts explain cross society variations
enhanced force model calculating tropical storm induced response long span bridges presented evolutionary power spectral density existing tropical storm wind model first enhanced taking consideration recently proposed turbulence spectra coherence transfer function matrix time dependent aerodynamic function introduced eliminate strip quasi steady theory assumptions way implementing wind tunnel measured span wise wise coherence aerodynamic forces finally non linearity forces resulting variations instant effective angle attack span wise profile mean wind speed considered enhanced model influence aforementioned enhancements force model tropical storm induced response long span bridges assessed example bridge subjected results suggest enhanced model tropical storm nonlinearity due instant effective angle attack variations velocity span wise profile slightly change responses however introduction span wise coherence forces increases extreme responses time dependent function reduces extreme responses much american society civil engineers
human body head highly related body shown transmit causative agent fever mechanisms body became vector however poorly understood following oral challenge green fluorescent protein expressing days number bacteria significantly higher whole body head numbers detected infected however approximately nevertheless viability significantly higher body comparison immune responses tract tissues revealed basal transcription levels recognition protein lower body transcription regulated oral challenge wild type head body addition level cytotoxic reactive oxygen species generated epithelial cells significantly lower body although time reduced immune response consistent higher vector competence seen body head terms infection
stone columns proved useful technique supporting flexible structures resting soft soils however case soft soils stone columns encountered excessive due insufficient lateral resistance offered soft soil columns upon loading reduced great extent reinforcing columns either geosynthetics placing horizontal circular geosynthetics within columns regular interval present study model tests carried long floating end bearing single groups columns without reinforcement evaluate relative improvement failure stress composite ground due different types reinforcement deformed column shapes used understand failure mechanism different types configurations reinforcement geogrid best geosynthetic type end bearing columns floating columns geotextile geogrid equally good horizontal circular configurations
controlled shape memory alloys new kind smart material used applications however hysteresis nonlinearity material obstacle achieving high precision accuracy describe hysteresis nonlinearity modeling method based proportional integral differential pid neural network proposed using training algorithms train weights model better approximate main minor hysteresis loops adding nonlinear function input layer simulation results show maximum prediction error pid neural network model given input signal results major hysteresis loop maximum prediction error pid neural network model given input signal results major minor hysteresis loops error calculations demonstrate effectiveness modeling method
created easy use device experiments another device records environmental variables devices use computer obtain data multiple input devices radio frequency identification tag readers touch motion sensors environmental sensors activate output devices led pumps needed data gathered devices stored locally computer automatically transferred remote server via wireless network tested device training rats obtain either sucrose water control fixed ratio variable ratio progressive ratio reinforcement schedule data demonstrated device sufficient precision time resolution record fast behavior rats data environment monitoring device also showed reliable measurements providing source code design open source license believe examples stimulate innovation behavioral studies
paper describes method fast identification thermal behavior vehicle integrated electric drives propose better understanding electric machine design tailored driving cycles simple satisfactorily accurate calculation method estimation machine losses input analytic thermal network early design stage introduced analytic models verified using measurement data used parameter case studies consideration thermal environment focus first case study analyzes influence thermal behavior critical machine components aiming use cooling winding heads improvement machine performance using alternative cooling approach end windings shown second case study
point cloud fundamental representation three dimensional geometric objects analyzing processing point cloud surfaces important computer graphics computer vision however existing algorithms surface analysis require connectivity information therefore desirable develop mesh structure point clouds task simplified aid parameterization particular conformal advantageous preserving geometric information point cloud data paper extend state art spherical conformal parameterization algorithm genus closed meshes case point clouds using improved approximation laplace operator data points propose iterative scheme called north south achieving spherical conformal parameterization balancing scheme introduced enhance distribution spherical parameterization high quality built point clouds aid also meshes generated guaranteed genus closed meshes moreover using proposed spherical conformal parameterization multilevel representations point clouds easily constructed experimental results demonstrate effectiveness proposed framework
order comply new requirement personnel training transformation local universities applied technological universities article associate teaching practice university aims promoting teaching reform updating teaching methods strengthening practical teaching changing testing methods reforms successfully initiative students obtained preliminary results
suicidal behavior among military personnel persists significant public health issue previous research indicates primary suicide attempts among military personnel desire reduce alleviate emotional distress finding studies samples much less understood consequences first suicide attempt influence occurrence additional suicide attempts order identify active duty attempted suicide first time multiple participated structured interviews focused experiences immediately following first attempt likely made multiple suicide attempts younger time first attempt admitted hospital treatment program first attempt experienced emotional psychological relief immediately afterwards results suggest experience emotional psychological relief immediately first suicide attempt receive treatment likely make additional suicide attempts elsevier ireland ltd rights reserved
paper compares field response two test constructed similar soft soil deposits strengthened foundation vertical strengthened foundation geotextile granular columns provided basal geogrid reinforcement effectiveness granular columns assessed comparing settlement horizontal displacement soft foundation excess pore pressures middle soft clay layer results showed granular columns significantly reduced maximum settlement occurring maximum horizontal displacement foundation settlement level load carrying capacity strengthened foundation found increase much around times strengthened one also observed geotextile granular columns caused noticeable reduction maximum excess pore pressure following load application furthermore degree consolidation achieved end construction quite high granular columns used
numerous policies proposed local state national level restrict youth access violent video computer games although studies cited support policies published research children perceive uses influence violent interactive games authors conduct focus groups boys ages boys use games experience power explore master perceive exciting realistic environments distinct real life work angry feelings relieve stress social tools boys believe violent games concerned younger children game behavior especially
research shown robust tendency people underestimate ability get others comply requests five studies demonstrate compliance effect reduced offer money exchange compliance studies participants assigned incentive monetary incentive condition made actual requests others studies offered incentives underestimated likelihood approached requests however offered monetary incentives prediction error mitigated studies present evidence support model explain underlying mechanism attenuation effect studies demonstrate offering monetary incentives activates money market frame study find activation reduces discomfort associated asking allowing accurately assess size request consequently likelihood compliance elsevier inc rights reserved
background patients moderate severe atopic eczema often require photo systemic immunomodulatory therapies induce disease remission maintain long term control current evidence guide clinical management small despite frequent often label use treatments registries patients photo systemic immunomodulatory therapies fill gap collection core set concerning therapies allow direct comparisons across registries data sharing using approach international treatment atopic eczema treat registry aims seek consensus key stakeholders internationally core set domains domain items patient registries research focus collect data children adults photo systemic immunomodulatory therapies methods design participants six stakeholder groups invited doctors nurses non clinical researchers patients industry regulatory body representatives comprise three sequential online rounds participants rate importance proposed domain domain items participants able add domains domain items proposed list round final consensus meeting held representatives stakeholder group discussion identifying uniform core set domains domain items captured patient registries increase utility individual registries provide greater insight effectiveness safety cost effectiveness photo systemic immunomodulatory therapies guide clinical management across dermatology centres country
project work package dedicated tools infrastructure inside task database virtual infrastructure task aims providing infrastructure store resources needed scientific work packages project infrastructure includes combination storage facilities relational databases web services top taken whole name knowledge base contribution illustrates current status details set data resources put together describes database allows data discovery inspired metadata maintenance illustrates discovery access services built top former two users exploit data content
metabolism plays key role many major human diseases generation high throughput data new era systems biology genome scale metabolic network reconstructions provide platform interpret data meaningful manner release global human metabolic network enabled new systems biology approaches study human physiology pathology pharmacology currently publications utilize including studies cancer diabetes host pathogen interactions heritable metabolic disorders target drug binding effects mini review focus reconstruction global human metabolic network four classes application show computational simulations numerous pathologies yielded clinically relevant results many corroborated existing newly generated experimental data
background recently role gastrointestinal modulating immune responses inflammatory immune mediated conditions allergy autoimmune diseases introduced mainly due suppressive effects somatic secretory products immune responses study evaluated immunomodulatory potentials somatic products gastrointestinal sheep suppress immune mediated responses murine model allergic airway inflammation balb mice sensitized challenged somatic products administered sensitization effects somatic products development allergic airway inflammation evaluated analyzing inflammatory cells recruitment histopathological changes cytokines production tgf beta serum antibody titers results somatic products able suppress induction allergic airway inflammation mice modulation type responses via tgf beta production observed injection somatic products addition inflammatory cells infiltration pathological disorders significantly diminished following administration somatic products conclusions data raised possibility potential therapeutic candidate alleviate inflammatory conditions allergic asthma according results concluded contain immune modulatory molecules attenuate allergic airway inflammation via induction regulatory cytokines investigations required identify molecules potentials development novel therapeutic targets
paper describes analog signal processing technique development novel electronic circuit embedded sensor integrated circuit board electronic signal processing detect energy centre optical signal represents accurate position measurement light source mounted structure like buildings bridges optical scanning sensor shm structural health monitoring proposed due fact signal processing stage embedded sensor require additional software processing reducing time memory spacing requirements information recording theoretical principle operation technological experimental aspects design development validation presented
letter propose road structure refined convolutional neural network approach road extraction aerial images order obtain structured output road extraction fusion layers designed architecture training new loss function proposed incorporate geometric information road structure cross entropy loss thus called road structure based loss function experimental results demonstrate trained model able advance state art road extraction aerial images terms precision recall score accuracy
purpose review objective review advances bile acids health disease published last years bile acid diarrhea bad recognized common cause chronic diarrhea recognition facilitated development new screening tests recent findings primary bad account cases chronic diarrhea mechanisms leading bad include inadequate feedback regulation fibroblast growth factor abnormalities synthesis degradation proteins involved regulation hepatocytes variations function bile acid receptor widely used test diagnosis bad significant validation fasting serum one surrogate measure bile acid synthesis bile acid primary treatments bad receptor pathway provides alternative therapeutic targets bad bile acid stimulated intestinal mechanisms contribute beneficial effects bariatric surgery obesity glycemic control treatment recurrent clostridium infection summary renewed interest role bile acids leading novel management diverse diseases besides bad
spectrum contains great deal information analysis spectra people get physical information bodies chemical composition atmospheric parameters implementation large scale surveys massive spectral data produced especially along formal operation spectral data generated observation night requires efficient processing technology cope massive spectra automatic classification spectra basic content spectral processing main purpose paper research automatic classification massive spectra index set standard indices defined spectra describe spectral intensity spectral lines represent physical characteristics spectra index relatively wide spectral characteristics line index named prominent absorption line paper bayesian method used classify spectra based line index spectra three subtypes first line index spectra calculated characteristic vector spectra bayesian method used classify spectra massive spectra computation indices spectral classification using bayesian decision method implemented hadoop use high throughput good fault tolerance combined advantages mapreduce parallel programming model efficiency analysis processing massive spectral data improved significantly main innovative contributions thesis follows using indices characteristic classify spectra based bayesian decision method implementing parallel computation indices parallel classification spectra using bayesian based hadoop mapreduce distributed computing framework
gene family performs variety functions plant growth development processes also play essential roles plant response environmental stresses plant small genome used model organism despite vital role genes plant growth regulation studies genes conducted date using reference genome data identified genes classified groups phylogenetic analysis located eight chromosomes structure analysis indicated genes retained relatively constant exon intron composition evolution genome closely related members phylogenetic tree similar motif compositions different motifs distributed different groups genes sources functional divergence genes expressed six tissues namely root blade flower tissues suggesting putative function many aspects plant growth development nine genes upregulated cold drought aba salt stress treatments indicating play vital roles response abiotic stress study provides valuable information utilized improve quality benefits plants
long non coding rnas represent new molecular biology play important roles regulating gene expression epigenetic transcriptional post transcriptional levels found play important roles normal cell physiological activities participate development varieties tumors diseases previously able determine function multiple mechanisms including genetic chromatin remodeling splicing regulation mrna decay translational regulation application technological advances research function extremely important major tools exploring include microarrays rna sequencing rna seq northern blotting real time quantitative reverse transcription polymerase chain reaction qrt pcr fluorescence situ hybridization fish rna interference rnai rna binding protein immunoprecipitation chromatin isolation rna purification bioinformatic prediction review highlight functions advanced methods research protein interactions
main design criteria modern sustainable development vehicle high energy efficiency conversion system competitive cost lowest possible environmental impacts need efficiency improvement vehicle energy system induces search innovative methodology design process article energy services mobility comfort integrated energy integration mobility comfort service applied innovative methodology combining process integration techniques methodology applied energy integration study hybrid electric vehicle powertrain vehicle energy balance internal combustion engine done discussed according operating points energy requirement comfort also determined according seasonal requirement heating cooling work cycles heat recovery described investigated minimum energy requirement determined different mobility comfort situations energy recovery potential single stage rankine cycle diesel engine combination hybrid electric powertrain assessed rankine cycle circuit equipment simultaneously
aim present study investigate whether age associated non alcoholic fatty liver disease later life methodsthe association age obesity insulin resistance menopause investigated cross sectional study postmenopausal chinese women diagnosed hepatic ultrasound information regarding age collected using administered questionnaire age logistic regression revealed women earlier higher risk age adjusted prevalence overweight obesity insulin resistance whereas later showed weaker still significant association lower prevalence however adjustment variables current body mass index bmi homeostasis model assessment insulin resistance attenuated association later lower prevalence decreasing trend risk seen across increasing levels age age adjusted trend multivariate adjusted trend multivariate current bmi adjusted trend multivariate adjusted trend associated prevalence later life independent bmi insulin resistance
luteinizing hormone rises dramatically menopause correlated increased incidence alzheimers disease decreased memory performance humans animal models test whether acts directly dorsal hippocampus affect memory ovariectomized female rats either human receptor antagonist infusion either lateral ventricle dorsal hippocampus caused significant memory impairments ovariectomized estradiol treated females consistent infusion antagonist dorsal hippocampus caused memory deficits ovariectomized females furthermore releasing hormone antagonist failed act campus affect memory findings demonstrate significant role action dorsal hippocampus spatial memory dysfunction elsevier inc rights reserved
purpose evaluate characteristics industry radiologists associations regional diagnostic imaging utilization methods using cms open payment data disclosed related industry radiologists identified health resources services administration area health resources files used identify actual population weighted numbers radiologists state utilizing random sample cms research files average medicare imaging spending per state calculated average frequency amounts non radiologists calculated state level using pearson correlation coefficient relationship frequency amounts radiologists versus per medicare imaging spending evaluated state level results overall radiologists diagnostic interventional received industry representing radiologists nationwide total individual transfers translated discrete per receiving mean median range food expenses constituted vast majority disclosed transfers followed travel educational expenses considerable geographic variation observed ranging radiologists district columbia correlation identified average per medicare imaging spending proportion funded radiologists state similarly correlation identified average per medicare imaging spending average transfer amount radiologists state conclusions small minority united states radiologists received industry state level medical imaging utilization seem influenced financial relationships
although olfactory sense always considered less interest visual somatic plays major role ordinary life important implication dangerous situations social emotional behaviors traditional diffusion tensor signal model related used past years reconstruct cranial nerves including olfactory nerve however supplementary information regard pathways olfactory network provided using advanced constrained spherical diffusion model show first time vivo non healthy humans olfactory system widely distributed anatomical network several cortical regions many subcortical structures although present study focuses healthy sample size similar approach applied near future gain important insights regard early involvement several neurodegenerative disorders
purpose paper develop model individual social behavior incorporates contributions personality actor relevant features situation performing analyzing original formula viz paper first considers importance situation previous analyzes contributions actors personality particular actors come develop broad situational outcomes associated situations encounter situations social psychological purposes terms potential yields relative actors motivations status situational defined normative prescriptions believed operative situation acceptable behaviors aimed actors goals status normative pressure objective though judged actor termed component situation held degree consensus others observers situation two components specify strength situation social psychological purposes yielding elaborated formula culture participants national organizational familial dyadic determine beta weights linking components formula
false memories influenced variety factors emotion variable special significance theoretical practical reasons interestingly emotions effects false memory depend whether embedded content remembered events mood aspect context events encoded theoretical basis content context dissociation review accumulated evidence content context effects indeed different paradoxically find experiments spontaneous implanted false memories negatively content distortion negatively protect addition correlational data show enduring negative natural depression false memory current process models false memory fuzzy trace theory able explain content context dissociation variations emotional content primarily affect memory events whereas variations emotional context primarily affect memory events exact form important questions remain effects modulated variations memory tests arousal promising methods tackling questions outlined especially designs separate influences emotion
developed fast selective sensitive line method simultaneous determination nine seven environmental urine widely used antimicrobial used inter polymers substances suspected endocrine limits quantification analytical quality criteria fully met needs determining exposure levels occurring general population analyzed spot urine samples general german population females males children found methyl ethyl high detection rates followed butyl iso butyl iso detected urinary concentrations highest methyl median percentile followed ethyl environmental high detection rates environmental found higher urinary levels females males children probably due differences personal care product use however high levels range also observed children exposure substances occurring worldwide differences countries seem exist caused different product compositions different use habits human metabolism data urgently needed urinary biomarker levels doses actually taken elsevier gmbh rights reserved
increasing evidence indicates central nervous system cns target air pollution previously reported postnatal exposure mice concentrated ambient particles via university system critical developmental window cns development equivalent human trimester produced male predominant neuropathological behavioral characteristics common multiple neurodevelopmental disorders including autism spectrum disorder asd humans current study sought determine whether vulnerability fine air pollution exposure extends embryonic periods brain development mice equivalent human pregnant mice exposed day gestational days using new york university system concentrated ambient fine particles average concentration course exposure period postnatal days neuropathological consequences characterized gestational air pollution exposures produced increased corpus area reduced hippocampal area sexes sexes demonstrated increased microglial activation reduced total microglia number analyses iron deposition critical component revealed increased iron deposition exposed female offspring males findings demonstrate vulnerability brain air pollution extends gestation produces features several neurodevelopmental disorders sexes highlight importance components particulate matter exposures source neurotoxicity common cns alterations
new water resources management methodologies needed address increasing demands future uncertainty urban water resources adaptive water demand management strategies provide approach improve efficiency water system operations meet water demands adapting flexibility increasing stresses study simulates adaptive water demand management development complex adaptive system modeling framework couples cellular automata modeling modeling hydrologic modeling simulate land use change consumer behaviors management decisions rainfall runoff process reservoir storage model applied simulate effect demand management strategies reductions municipal water demands sustained storage surface water supply reservoir historic projected climate change time series used assess effectiveness domestic water restrictions including outdoor restrictions rainwater harvesting program high density land use change policy strategies adaptively implemented based amount water storage available framework applied evaluate strategies texas metropolitan area historically suffers severe framework provides approach evaluate combination multiple strategies effectively managing increasing stresses caused urbanization population growth climate change results demonstrate adaptive demand management strategies respond water result long term per capita demand reductions climate projections forecast severe water development density strategies effective rainwater harvesting strategies combination strategies reduce need transfers maintain reservoir volumes american society civil engineers
body signals two different ways perceiving self first within second outside investigated relationship accuracy external perception body tested seeing body external perspective affect fifty two healthy female subjects performed standard perception task assess body image body perception task designed assess different aspects body image performance lower group perception task significantly improved task findings highlight relations body representations supporting view two kinds awareness linked interact elsevier ltd rights reserved
method developed assessing total viable count storage using hyperspectral imaging technique study hyperspectral images visible near infrared vis nir region acquired fifty samples vis nir diffuse reflectance spectra extracted images reference values samples determined classical microbiological method partial least square regression model support vector machine regression model built comparative analysis achieve better results different transformation methods filtering methods applied improve models results show optimized model model predict model based second derivation better achieved correlation coefficient prediction set standard error prediction set log cfu prediction set image processing algorithm developed transfer prediction model every pixel image entire sample visualizing map displayed real time detection process due simplicity model results demonstrated hyperspectral imaging potential reliable approach non destructive real time prediction
background right ventricular cardiomyopathy genetically heterogeneous condition caused mutations genes encoding proteins cases genotype negative cases point need identifying novel genetic substrates studying genotype negative families methods results whole exome sequencing performed validation heterozygous variants survived internal quality frequency filters performed sanger sequencing variants also genotyped family members establish genotype phenotype high resolution melting analysis followed sanger sequencing used screen mutations cadherin gene unrelated genotype negative patients generation family identified whole exome sequencing novel mutation affected family members variant present chromosomes available public databases changes conserved amino acid cadherin protein supported causal mutation parametric linkage analysis subsequently screened genotype negative tested previously mutations known genes found additional likely pathogenic variant encodes cadherin also known cadherin protein plays vital role cell adhesion making biologically plausible candidate gene pathogenesis conclusions data mutations novel genetic causes contribute complete identification disease genes involved cardiomyopathy
monte carlo method used quantitative structure activity relationships modeling derivatives acting inhibitors quantitative structure activity relationships models calculated representation molecular structure simplified molecular input line entry system one random split training test set statistical quality developed model good best calculated quantitative structure activity relationships model following statistical parameters training set test set structural indicators defined molecular fragments responsible increases decreases inhibition activity calculated computer aided design new compounds potential inhibitors application defined structural presented
extending research study examined effects sport production sport consumption experimental design crossed sport violence investigate effects variables violent outcomes enjoyment viewing one four clips participants responded three incomplete story stems responses coded measure hostile expectancy bias form violent outcome participants also responded enjoyment consumed analyses showed main effect consuming sport violence increased participants hostile expectancy bias however significant interaction showed moderated effect violence increased hostile expectancy bias condition enjoyment also affected violence violent sports conditions results suggest violence sports interpreted differently based sport processed differently violence forms entertainment implications findings discussed limitations future directions study
paper presents information system multidimensional data analysis data mining identification associative multidimensional data implemented post relational cache environment information system modules considered perform next tasks design object database physical level construction multidimensional data structures creation database association rules mining among multidimensional data methods construction considered association rules mining implemented information system
evaluate effect continuing care interventions cocaine use hiv risk reduction components hiv sex risk explore whether cocaine use treatment initiation interacts type continuing care intervention affect hiv sex risk cocaine dependent participants randomized treatment usual tau intensive outpatient treatment tau telephone monitoring counseling tau plus incentives participation telephone contacts participants received brief hiv intervention sessions needed generalized estimating equations analysis compared tau months post baseline following outcomes overall hiv sex risk number sexual partners condom usage exchange drugs sex exchange sex drugs exchange money sex exchange sex money crack house visits overall sex risk decreased treatment conditions follow treatment main effects people cocaine use baseline tau experienced greater sex risk reductions three treatment conditions effective reducing hiv sex risk hiv risk reduction components unnecessary cocaine dependent clients stop using cocaine early treatment
background society thoracic surgeons american college cardiology valve therapy registry captures procedures food drug administration approved valve devices performed united states mandated condition reimbursement centers medicaid medicare services objectives annual report focuses patient characteristics trends outcomes aortic valve catheter based valve procedures united states methods reviewed data patients receiving commercially approved devices december entered registry results patients aortic valve replacement demonstrated decreases expected risk day operative mortality predicted risk mortality aortic valve replacement observed hospital mortality decreased year mortality decreased however day post procedure insertion increased patients underwent similar patients hospital mortality reduced grade patients patients underwent valve valve ring procedures high risk valve replacement observed hospital mortality day post procedure mortality conclusions registry innovative registry monitors quality patient safety trends rapidly evolving new technologies american college cardiology foundation society thoracic surgeons published elsevier inc behalf american college cardiology foundation rights reserved
cold major constraint tomato growth productivity cold sensitive crop plays key role generating cold tolerance tomato regulating response multiple genes stress study cold tolerant gene driven promoter transformed three tomato genotypes agrobacterium tumefaciens employing tissue culture independent transformation strategy seeds tomato surface day old shoot apical developing incubated twenty minutes tumefaciens strain treated seeds cultivated agrobacterium days regenerated shoots subjected selection period weeks presence genes resistant transgenic plants evaluated pcr analysis transgene activity detected plants reverse transcriptase polymerase chain reaction southern blotting showed stable integration transgene next generation physiological analysis transgenic plants depicted increased expression induced stress various stresses conductance rate relative water contents transgenic lines significantly higher plants leaf osmotic potential transgenic plants lower compared plants established procedure novel produce stable transgenic tomato plants efficient manner saving potential resources terms cost time
sports related distal radius fractures represent fractures affecting upper extremity type fracture occurs frequently males females average age presentation years pediatric population peak incidence sports injuries years high impact sports football soccer carry especially high risk type injury however wide variety sport disciplines different characteristics demand velocity energy use upper extremities uniform pattern general principles diagnosis treatment distal radius fractures athletes part follow general population however unique aspects clinical approach athlete frequently require additional radiographic views common need advanced imaging computer tomography scans magnetic resonance imaging athletes constitute special patient population elite athletes highly motivated return competition soon possible frequently willing accept risk poor healing repeat injury treating physician subjected pressure end immobilization reduce recovery time even remove plates alter therapy based competition requirements influences mitigated favor long term benefit patient elsevier inc rights reserved
appropriately merging visual words effective dimension reduction method bag visual words model image classification approach merging visual words extensively employed gives fully determined merging hierarchy existing supervised hierarchical merging methods take different approaches realize merging process various formulations paper propose unified hierarchical merging approach built upon graph embedding framework approach able visual words scenario preferred structure undesired structure defined therefore effectively attend kinds requirements word merging process terms computational efficiency show algorithm seamlessly integrate fast search strategy developed previous work thus maintain state art merging speed best survey proposed approach first one addresses hierarchical visual word flexible unified manner demonstrated maintain excellent image classification performance even significant dimension reduction outperform existing comparable visual word merging methods broad sense work provides open platform applying evaluating developing new criteria hierarchical word merging tasks
study investigated quality life adjustment mechanisms parents children attention deficit hyperactivity disorder adhd ninety parents children adhd completed sociodemographic questionnaire self assessment scales measure perceived stress social support sense control coping strategies quality life adhd children negatively affected parents quality life especially psychological personal family couple relationships daily life activities also affected severity disorder perceiving situation threat loss feeling holding beliefs related emotion focused coping strategies poorer quality life furthermore hyperactivity index stress ratings relative perceiving situation threat loss adopting emotion focused coping strategies predicted poorer quality life contrast perceiving situation challenging related greater sense control personal moreover perceiving situation challenging adopting problem focused coping strategies predicted better quality life findings highlight negative effects adhd parent psychological adjustment underline need recommend training programs improve parenting skills parents perceptions concerning childs behavior disorder parental functioning
relevance known traditional chinese medicine widely used effects suppressing fever fire removing owing complexity difficult understand pharmacokinetic properties detail aim study develop optimal proteomics approach analyze protein profiling related rat liver treated compatibility materials methods male rats respectively administered extracts mixture days liver tissue samples prepared comparative proteomic analysis significantly differentially expressed proteins experimental groups control group found identified maldi tof analyses validate proteomic analysis results peroxidase catalase methyl transferase selected confirmed western blotting results seventy eight significantly differentially expressed proteins experimental groups control group found identified querying relational databases identified differentially expressed proteins summarized classified three groups phase drug metabolic enzymes phase drug metabolic enzymes rest proteins mainly involve energy metabolism signal transduction cytoskeleton proteins involved targets metabolic studies markers toxicity conclusions findings indicated compatibility influence expression proteins rat liver administration majority expressions presented downward trend closely related pharmacological properties medicine method study open new road complementary tests properties compatibility elsevier ireland ltd rights reserved
escherichia coli related illnesses continue one important global public health problems world study aims determine coli prevalence chicken meat parts samples collected randomly several city southeast turkey analyzed confirmed using separation microbial identification system polymerase chain reaction pcr method study also aims detect presence genes using pcr overall coli prevalence chicken meat parts coli isolates carried genes genes coli isolates obtained breast meat carried either genes related important virulence factors disease
communication ether nature thus wireless networks often deemed unsuitable support time critical distributed control applications like floor industrial plants however scheduling techniques derived real time operating systems along channel redundancy run time management applied wireless networks improve paper presents novel approach combines solutions preliminary prototype implementation relies ieee set assess feasibility performance approach results show data exchange improved degree makes wireless networks actually suitable many soft real time applications
recent increase demand wind turbines given rise concerns availability materials used construction combination wind turbine coupled hydraulic pump instead electrical generator offers alternative application renewable energy technology article analyses dynamic response wind hydraulic system consisting wind turbine driving plate pump done means mathematical models utilising matlab simulink operational aspects proposed wind hydraulic pumping system validated standard baseline wind turbine model national renewable energy laboratory control issues encountered wind turbines hydraulic systems analysed wind turbine control systems used run electrical generators adopted control pressure controlled plate pump pump applications controlled varying plate angle thus controlling pumps output power torque methods generation artificial wind data also included simple wind speed time series developed time series used test wind turbine hydraulic system varying wind conditions using concept control regions models developed show standard steady state response wind turbine together dynamic behaviour wind turbine control parameters established system also presents wind turbine controller analyses behaviour system typical extreme wind conditions study concludes system significant potential technically achievable
objective borderline personality disorder bpd high prevalence personality disorder pharmacotherapy commonly used however minority studies investigated patterns prescription bpd particularly inpatients unit aimed describe clinical features prescribing practice bpd patients investigate possible advantages single class medications combined drug treatments terms length stay retrospective observational study evaluating bpd inpatients june june evidence extensive use drugs antipsychotics mood antidepressants common longer length stay hospital associated prescription antipsychotic antidepressant medication shorter hospitalization associated use mood rates prescription different classes drugs reported sample similar naturalistic studies highlight heterogeneous pattern prescriptions bpd mood showed favourable profile terms length stay hospital antipsychotic antidepressant results discrepancy international recommendations everyday clinical practice
obesity increasing prevalence across sectors society associated including hypertension type diabetes eating disorders system critical neural system underlying control body weight functions deficits system promote exacerbate comorbidities obesity system therefore generated great interest potential target treatment obesity however drugs targeting receptors problematic side effects including undesirable increases sympathetic nervous system activity heart rate blood pressure require picture precise neural circuits mediate functions recent novel experimental approaches significantly advanced understanding pathways review latest advances understanding role food intake reward pathways blood pressure glucose control energy expenditure evidence suggests downstream responsive circuits responsible different physiological actions ultimately complete understanding pathways myriad roles allow treatments tailored mix metabolic disorders individual patient author published karger basel
electrical analogy used solve numerical problems fluid mechanics used solve classical problem flow two parallel plates flow pipe transient free convection flow along semi infinite vertical wall nonlinear system partial differential equations numerically solved network simulation method based thermo electric analogy simulator electrical devices permits direct visualization local integrated transport variables temperatures velocities concentrations fluxes point section medium time solution transient steady state problems obtained requirement finite difference schemes spatial variable educational tool seen useful solving numerical problems engineering used graduate university wiley periodicals inc appl
morality prominent guide action perception argue non emotional gestures prime abstract concept four studies demonstrated gesture associated hand ones heart increased level perceived others increased shown ones behavior target persons performing gesture described terms associated appeared trustworthy others targets control gesture persons performing hand heart gesture provided assessments others attractiveness compared persons performing neutral gestures findings suggest bodily experience associated abstract concepts influence ones perceptions others ones complex actions findings suggest influence mediated changes affective states
investments european structural pursue goals smart inclusive sustainable growth many cities europe rather growing policy makers practitioners therefore face challenges ensuring places limited growth potential fall behind scholars argue cities long term decline benefit enhancing capacity develop collaborative initiatives draw local resources assets practice local decision makers seem struggle engage communities fight causes consequences decline paper advances argument concept production suited explore explain collaborative actions new strategic choices based capabilities resources local actors control case study small manufacturing town germany used illustrate production different levels lead tangible long term improvements context ongoing shrinkage
purpose review update healthcare providers potential contribution increased basal metabolic rate low testosterone development weight loss cancer patients recent findings cancer loss skeletal muscle without loss fat multifactorial syndrome wide variation frequency exists cancer patients accurately identified indirect frequency increases depending histology stage tumor associated presence acute inflammatory response often accompanied weight loss hypogonadism result chemotherapy radiation treatment use opioids treat chronic pain frequently noted male cancer patients reported also associated anorexia weight loss summary cancer patients develop weight loss patients family treatments directed reducing basal metabolic rate supplementation testosterone male patients potential improve lean body mass research needed
wind energy many advantages source however evaluation control schemes electrical generator hard wind turbine since wind speed varies similar environment turbine wind turbine purpose wind energy energy efficiency extract maximum power wind speed words power maximum therefore maximum power point tracking case control becomes important realize control strategy conventional proportional integral controller usually used however strategy achieve better performance paper proposes robust control turbine optimizes production improve quality energy efficiency namely strategy sliding mode control proposed sliding mode control strategy presents attractive features robustness parametric uncertainties turbine proposed sliding mode control approach applied wind turbine matlab simulink
increase urban population high rise buildings widely applied foundation basis building quality directly relative safety building according practical example foundation engineering high rise building paper established parameterized model foundation engineering bim technology simulated whole process foundation construction quickly complete transmission construction information accomplished cooperative work platform bim collision reinforcement clearance done collision problems joints early time compared traditional construction management method found application bim technology control construction quality effectively optimize resource allocation ensure safety foundation engineering
significant problem river bank coastal protection systems severe cause damaging consequences geotextile tube structures study five case scenarios system supported stacked geotextile tubes analyzed using commercially available finite element analysis software case scenarios include conventional geotextile tube ground base foundation geotextile tube gravel foundation geotextile tube foundation geotextile tube foundation gravel stacked geotextile tubes protection case scenario simulated normal loading critical loading conditions without base system results suggest potential problems occur critical states system failures geotextile tube retaining structure among case scenarios considered additional increases performance global stability geotextile tube system american society civil engineers
objective despite great number substances produced industry seem truly effect skin therefore given social implications surrounding physical appearance search new bioactive compounds prevent attenuate skin ageing enhance self image priority current research context rich valuable compounds proteins lipids vitamins study focused potential activity press used raw materials applications methods study protein rich press residue oil industry converted short chain biologically active peptides using four protease products varying substrate specificity antioxidant anti anti inflammatory activities obtained evaluated biocompatibility human skin fibroblasts tested results skin fibroblasts exposure non extract induced cell toxicity obtained promising extracts showing improved suitable skin anti ageing formulations namely antioxidant activity inhibiting approximately cellular reactive oxidative species anti inflammatory anti properties inhibiting around activity activity conclusion enzymatic technology applied oil industry results release bioactive compounds suitable applications
strategy games traditionally applied teaching subjects related decisions making principally university studies related company nevertheless potential methodology makes also applicable studies lead applicable practices companies like happens technical present paper shows methodology applied teaching engineering plant inside official master manufacturing engineering university context material forming machine chip removal experience distributions process product simulated determining domain pass one another preceded determination finally discussion driven emphasize importance reduction dead times due movements
paper present novel kernel adaptive recurrent filtering algorithm based autoregressive moving average model trained recurrent stochastic gradient descent reproducing kernel hilbert spaces recurrent system kernel adaptive algorithm brings together theories adaptive signal processing recurrent neural networks extending current theory kernel adaptive filtering using theorem include feedback compared classical feedforward methods algorithm provides general nonlinear solutions complex dynamical systems state space representation teacher signal propagating forward hidden states demonstrate capabilities provide exact solutions compact structures solving set benchmark polynomial complete problems involving inference simulation results show algorithm outperforms equivalent input space recurrent architectures using first second order demonstrating potential effective learning solution identification synthesis deterministic finite automata
aim hepatocellular carcinoma hcc sixth common malignancy worldwide liver largest human digestive gland abundant apparatus involved cell division migration apoptosis others methods present study apparatus hcc surrounding liver tissues isolated sucrose density gradient identified electron microscopy enzymology methods using gel electrophoresis mass spectrometry differentially expressed protein apparatus hcc surrounding liver tissue screened identified database results differentially expressed proteins six upregulated downregulated related biological processes protein sorting glycosylation cell cycle regulation transcription regulation integrity one protein verified upregulated hcc western blot conclusion differentially expressed proteins provide new insight hcc biology potential diagnostic therapeutic biomarkers
agent commonly used treat ventricular arrhythmias iodine containing compound associated several adverse events like tends accumulate several organs among serious pulmonary toxicity incidence complication decreased use lower doses occur dose pulmonary complications usually present acute chest ray high resolution computed tomography diffuse found present case acute respiratory distress syndrome like features detected got stopping tablet patient known case atrial fibrillation taking tablet last six months
much work conducted use recovering potential energy possible method reduce energy consumption using lift work objective study evaluate capacity new energy efficient hydraulic lift cylinder secondary cylinder built piston rod store potential energy lowering form hydraulic oil using stored energy next lift mounted manipulated enable use also standard cylinder compared standard cylinder terms function energy consumption repetitive tested settings saved approximately energy consumed first part total lift energy possible adjustments optimization size enlargement assisting cylinder diameter enhancement importantly reduction internal leakage current commercial potential
display wide variation physiological responses stress clearly evident plasma corticosteroid changes cortisol levels fish known indicator fish stress simple rapid method detecting cortisol changes especially sudden increases desired study describe enzyme functionalized label free system detecting fish cortisol levels detection cortisol using achieved anti cortisol antibody selective detection cortisol glucose oxidase signal amplification non toxic measurement electrode surface self assembled monolayer system based maximum glucose oxidation output current change induced generation non conductive antigen antibody complex depends levels cortisol sample responded cortisol levels linear decrease current range since dynamic range sensor cover normal range plasma cortisol fish samples obtained fish need electrochemical measurement one sample required similar min sensor system applied determine cortisol levels plasma sampled compared levels samples determined using conventional method elisa values determined using methods correlated findings suggest proposed label free useful rapid convenient analysis cortisol levels fish without sample dilution also believe proposed system integrated miniaturized point care cortisol detection useful portable diagnostic fish farms future
multidrug toxin transporter family comprises members genome play seemingly important yet mostly physiological functions employed bioinformatics molecular genetics identify characterize transporters involved acid export tolerance translocation acid transporter induced deficiency overexpression roots altered homeostasis hormone levels deficient conditions plasma membrane acid transporter primarily expressed root epidermal cells mutant less root growth wild type stress seedlings deficient conditions overexpression rendered roots tolerant toxicity involved development iron homeostasis hormone signaling mutant delayed development leaves mature plants knock overexpression mutants showed altered accumulation abnormal hormone levels compared wild type demonstrate zinc finger transcription factor essentially required expression plant resistance toxicity proper expression two previously characterized flavonoid transporters also depends several transcription factors study reveals functional diversity transporters regulatory mechanisms stresses also light role metal nutrition hormone signaling various stresses significance statement many transporters potentially diversified functions analyzed mutants overexpression lines two transporters involved acid export aluminum tolerance iron translocation one transporter affecting growth development iron homeostasis manipulating expression transporters prove useful improving tolerance acidic soils aluminum stress
currently serious investigations made now road security critical research domain however majority based expensive infrastructure paper propose new scheme spreading vehicles without dependence road foundation new concept active vehicle combines power intelligence ambient technologies introduced alert endorsement suggest new model trust management based cooperation active vehicles order enhance security states cut spread false network authors published elsevier
adenosine involved many metabolic reactions also role cellular danger signal transmitted receptors indeed adenosine atp bind found membrane many cell types although relative proportions receptor subtypes differ classified according genetic pharmacological criteria especially affinities agonists transduction mechanism extracellular atp release activated cells activate various especially best characterized immune cells known regulate activation like receptor family protein permit release potent pro inflammatory cytokine pathway involved many inflammatory diseases fibrosis diseases associated inflammatory process liver lung fibrosis authors imaging also real promising therapeutic potential thus several pharmaceutical companies developed antagonists novel anti inflammatory drug candidates clinical trials efficacy antagonists now underway better understanding signalling pathways permits identification targets development new class drugs able inhibit process collagen deposition
propose incorporate encryption procedure compression voice data pcm pulse code modulation based law approximation quantization proposed chaotic pulse code join encryption compression voice data scheme provides compression ratio given pcm content comparisons many used schemes made highlight proposed method terms security better alternative classical methods time resource consuming non suitable real time multimedia secure transmission
human mesenchymal stem cells attracted much attention tissue repair wound healing self renewal capacity order mediate effective therapy substantial numbers cells required necessitates extensive sub expansion throughout vivo expansion cells undergo telomere shortening critically short telomeres trigger loss cell viability telomeres structures cap ends chromosomes serve protect dna degradation occurs due end replication problem eukaryotes finite ability self renewal like somatic cells telomere length provides critical information capacity cells important criterion selection therapy telomere length generally quantified southern blotting fluorescence situ hybridization recently pcr based methods describe quantification telomere length real time pcr results demonstrate effect telomere shortening proliferation thus assay constitutes useful tool determination relative telomere length elsevier rights reserved
established low level visual features affect person categorization bottom fashion studies examined top influences however largely focused information recalled memory motivation influences categorization investigated race affected context targets perceived manipulating semantic information associated faces categorized found presenting faces systematically varied racial ambiguity race congruent incongruent semantic labels shifted threshold perceivers distinguished racial groups semantic information offered labels therefore appeared influence categorization race findings suggest semantic information creates context interpretation perceptual cues social categorization highlighting active role top information race perception
although long used model system field enzymology several details mechanism still understood particular significant questions remain concerning disposition role catalytic metals previous metal rescue experiments using minimal resulted prediction catalytic metal bound site ground state reaction bridges phosphate along reaction pathway native extended constructs contain tertiary contacts stabilize compact structure moderate ionic strength performed rescue experiments extended using stereo pure substituted substrates order determine whether metal ion makes contact phosphate ground state along reaction coordinate inhibition rescue specific phosphate affinity measured two different ionic strength backgrounds increased fold pro oxygen replaced sulfur data support model metal ion makes ground state interaction phosphate native resulting model activation places metal ion contact phosphate provide ground state electrostatic activation substrate
review examines detail analyses eradication within broad context american cold war politics exercise technological medical political power part united states result book provides unique perspective eradication
several previous studies outlined importance histone regulation stem cell study investigated role cell development using mouse models allow conditional ablation late stages development found involved maintenance activation survival cells ablation resulted twofold reduction cell numbers also led cell state accompanied impaired proliferation increased pro inflammatory cytokine production vivo stimulation phenotypes increased apoptosis preferential regulation tumour suppressor protein cells lastly examined model experimental cerebral malaria pathology critically dependent cells mice cell compartment cell numbers remained reduced following infection periphery brain mice displayed improved survival parasite challenge collectively data identify novel factor cells immune system increasing understanding role histone cytotoxic cell biology
large left hemisphere found year old woman diagnostic statistical manual dsm diagnosis schizophrenia characteristics indicated acquired gestational weeks major waves neuronal migration left temporal occipital lobes inferior parietal surprisingly evidence contrast cognitive functions dependent integrity right hemisphere severely impaired test hypothesis development language took place expense functions normally carried right hemisphere investigated correlates oral comprehension fmri proxy auditory comprehension cognitive functions strongly posterior left hemisphere reading comprehension language engaged homologous area right represent natural model predictable prenatal development
social cognition refers ability use social cues infer meaning intentions behind behaviour others order respond socially adaptive manner increasingly recognised disorders social cognition including problems emotion perception theory mind inference morality decision making social inhibition characterise many developmental psychiatric disorders highly relevant many acquired brain injuries diseases especially frontotemporal review provides introduction overview papers special edition social cognition places context recent research several current issues clinical management social cognition delineated given social cognition seems sensitive predictor psychosocial function assessment social cognition seen many clinicians important although profession responsible yet resolved issues social cognition assessed discussed including importance context social cognition interactive nature need influences family gender emotional state social cognitive performance also needs development tests address aspects social cognition including decision making inhibition finally review discusses intervention research interventions especially developed relation schizophrenia less developed brain injury appear generally effective although treatments emotional self awareness yet developed
objective objectives study describe mri findings bone marrow edema patients phenomenon discuss clinical implications mri findings conclusion progressive distal proximal pattern bone marrow edema mri patients knowledge allow early diagnosis treatment disorders potentially associated
background unlike tablet formulation liquid directly absorbed intestine aim study assess whether superior overcome interference induced ingestion multiple interfering drugs methods prospective cohort study recruited patients apparent reduced absorption due switched maintaining daily dose ingestion serum tsh assayed least twice every eight weeks results serum tsh significantly lower compared patients took either replacement tsh suppression difference evident already first measurement post switch regardless purpose therapy patients took two lower serum tsh compared patients took three interestingly patients failed reach target tsh levels took three conclusions overcomes concurrent interference exerted ingestion multiple cases switching permits patients reach target tsh within
multi scale ordered patterns multi component polymer mixtures reveal many peculiar chemical physical properties makes systems important potential applications materials engineering via computer simulation create interesting ordered multi scale structures polymer mixtures system employed comprises ternary polymer blends three components mutually polymer non active polymers exhibit reversible chemical reaction reversible induced light firstly investigate phase behavior ternary blend guided cross mask light find like ordered pattern forms mixture removing mask regions components gather core structures area components gather star structures crossed regions remove mask entire system becomes reaction reversible occurs throughout film core structures components turn spherical structures star structures components turn square ring structures show influences number cross initial composition formation structure average spatial volume fraction component first increases decreases number increasing component net play important role stability ordered structures secondly blend covered mask component regions components radial arrangement result mixture forms interesting like pattern however mask removed reactions occur components whole region increasing free energy induces like pattern broken change dots ring structure forms perfect ring pattern target like pattern also show effects initial composition ratio component distance two adjacent rings ring width illumination intensity evolution ordered structure larger initial composition ratio component easily ordered target like pattern forms larger distance smaller width better effect component illumination intensity little influence ordered morphology ternary system provide simple approach creating multi scale films long range order guide nanoscale devices
magnesium extensively used treating liver injury common adverse reaction due narrow therapeutic window small changes pharmacokinetic profiles alter toxicity therapeutic efficacy significantly study aimed explore effects disposition potential mechanism induced liver injury pharmacokinetics tissues distribution behaviors showed significant difference group group mrna protein levels cytochrome liver intestine kidney significantly upregulated glycoprotein obviously downregulated compared immunoglobulin igm upregulated igm recovered normal levels complement upregulated significant effects disposition induced liver injury additional potential drug drug interaction happen administered antitumor drugs substrates mechanism perhaps upregulation downregulation igm
alcohol smoking frequently occur alcohol primary trigger smoking behavior relapse back smoking study examined whether several indices alcohol use behavior consequences use associated changes implicit alcohol approach versus implicit cigarette approach cognitions cigarette deprived non deprived cognitions smokers risky non risky levels implicit association task measured quickly respondents paired alcohol cigarette pictures approach avoid words regression analyses examined associations quantity frequency proportion heavy drinking days number dsm alcohol use disorder symptoms risky drinking status scores deprived conditions controlling order effects non deprived score deprived cigarette withdrawal interactions withdrawal intensity also examined results showed significant positive association proportion heavy drinking days stronger alcohol approach cigarette approach motivations deprived also conditional association symptoms alcohol approach motivations among respondents reporting intense withdrawal deprived alcohol quantity frequency risky drinking status unrelated change scores findings suggest cigarette deprivation motivation drink rather smoke among smokers engage frequent heavy drinking report alcohol related problems results also show relative preference choice cigarettes high risk smokers cigarette withdrawal high elsevier ltd rights reserved
loop technique proposed overcome problem close loop performance digitally controlled single inductor multiple output boost converters start presented technique existing clock source requires small number blocks also occupies smaller silicon area thus consuming low power increasing efficiency presented technique validated proposed chip digital controller multiple output boost converter architecture using segmented delay line digital pulse width modulation experimental results show successful close loop reduced transients using simpler technique
cysteine final product sulfate assimilation pathway bacteria plants serves precursor sulfur containing biological compounds methionine methionine iron sulfur clusters glutathione moreover several microorganisms cysteine plays role reducing agent eventually host oxidative defense strategies cysteine synthesized dependent enzyme belonging fold type beta replacement reaction review spectroscopic properties catalytic mechanism three dimensional structure conformational changes accompanying catalysis determinants enzyme stability role selected amino acids catalysis regulation enzyme activity ligands interaction serine preceding enzyme biosynthetic pathway described given key biological role played bacteria inhibitors potential antibiotic activity developed article part special issue entitled enzymology elsevier rights reserved
autophagy highly conserved pathway mediates bulk degradation cellular components plays important role fungi impacting growth morphology development however leaf role autophagy poorly understood study identified structure autophagy leaf infection structures using transmission electron microscopy tem results suggest autophagy strongly induced mother cell occur special infection structures vesicle applying autophagy inhibitor leaf resulted significant arrest growth delays leaf infection results suggest autophagy induced important fungal infection wheat research help expand understanding physiological functions autophagy fungi
interest tau protein fast increasing alzheimers disease diagnosis urgent need highly sensitive specific diagnostic platforms quantification also combination hallmarks now poorly exploited tau detection due sensitivity limits level whereas clinical requirement range molecular architectures built layer layer fashion biomolecules nanostructures metallic amplify signal improve limit detection desired sensitivity mostly gold nanostructures widely employed aim great interest also emerging multi walled carbon nanotubes modified secondary antibody tau protein eventually took advantage antibody conjugate obtain sandwich based capability increase signal folds compared direct detection conventional sandwich respect results hope give strong impulse investigation studying possible roles carbon nanotubes optical based
psoriasis chronic systemic immune mediated inflammatory associated several comorbidities psoriasis patients increased risk developing cardiovascular diseases cvd namely coronary heart disease stroke peripheral vascular disease psoriasis seems independent cardiovascular risk factor systemic therapy especially anti tumor necrosis factor tnf seems exert beneficial effect comorbidities purpose study measure level cardiovascular serum markers psoriasis patients comparison healthy volunteers compare serum level markers patients months adalimumab therapy investigated six biomarkers connected cvd reactive protein measured high oxidized low density glycoprotein complex vascular endothelial adhesion molecule interleukin biomarkers measured patients moderate severe psoriasis treatment adalimumab healthy volunteers complex significantly increased comparison healthy controls whereas also higher psoriasis patients difference reach statistical significance decrease observed months adalimumab therapy inhibition tnf seems improve psoriasis also decreases serum cardiovascular biomarkers serve monitoring efficacy systemic therapy cardiovascular risk
advances forensic identification using molecular genetics helpful resolving historical aim study confirm head artifacts exhibited two polish heads known south american special preparation preserved hair facial appearance however quite common offer heads monkeys collectors sampled small skin specimens four head skin collection poland following genomic dna isolation highly polymorphic short tandem repeats genotyped using commercial chemistry dna sequencing analyzer human chromosome identified obtained informative genetic profile genomic short tandem repeats samples heads moreover amplification loci allowed sex determination four studied heads human origin two ones shared chromosome characteristic indigenous americans detected another artifact chromosome found characteristic southeastern european origin commercial genetic methods identification applied successfully studies origin unusual collection items
better memory positive information compared negative neutral information repeatedly associated successful aging main psychological explanations called positivity effect memory principally rely emotional motivational cognitive mechanisms make older adults cognition highly sensitive positive information according ultimate goals however emerging evidence also genetic profile positivity effects memory render older adults prone others encoding remembering positive memories first present brief overview behavioral neuroimaging studies positivity effect aging subsequently report studies candidate genes associated positive memories particular review work date several candidate genes sensitive stimulus valence finally propose future approach study genetic correlates positivity effects memory also include mitochondrial functioning altogether study genetics cell biology positivity effects memory help reveal underlying bottom pathways positive affect healthy aging elsevier inc rights reserved
background practice important step confirm location sensitized reflects diagnosis stimulated specialized needle treat disease abnormal symptoms sensitized patients visceral disorders considered relation referred pain neurogenic inflammation yet limited study investigated cutaneous neurochemical changes sensitized methods study developed animal model gastric mucosal injury administered stomach rats blue dye applied injection tail vein mucosal damage observe neurogenic plasma dots skin rats dots skin compared locations analysis used detect expression gene related peptide substance labeled nerve fibers histamine serotonin labeled cells dots images recorded analyzed confocal imaging system image processing software results results showed resulted neurogenic plasma skin back abdomen mostly occurred dots appeared disappeared gradually natural self recovery gastric mucosa positive nerve fibers distributed dots regions beside dots control mostly distributed nerve fibers around vessels root hair follicle mast cells also aggregated release substances around vessels areas dots conclusions results indicates mechanism skin induced closely related neurogenic inflammation high expression local allergic substances local skin including mast cell underlying mechanism sensitization
paper mathematical model induction generator based distributed electrical parameters presented transient electromechanical processes occurring power system analyzed case unbalanced load interdisciplinary method coming modification principle used order formulate state differential equations numerical simulations made results simulations presented paper graphs
based foods key components diet dominate food based dietary recommendations order achieve targets intake carbohydrate protein dietary fibre processing milling grains produce refined grain products removes key nutrients although countries nutrients replaced mandatory overall refinement reduces potential nutritional quality increasing evidence observational intervention studies increased intake less refined whole grain foods positive health benefits highest consumers consistently shown lower risk developing cvd type diabetes cancers consumers also better digestive health likely lower bmi gain less weight time bulk evidence benefits comes observational studies evidence benefit intervention studies potential mechanisms action increasing overall evidence supports promotion foods refined grain foods diet require adoption standard definitions whole grain whole grain foods enable innovation food manufacturers provide clarity consumer encourage implementation food based dietary recommendations public health strategies
apoptosis dna oxidative damage serve significant roles pathogenesis steroid induced femoral head necrosis vitamin demonstrates anti apoptotic anti oxidant properties therefore present study investigated effects vitamin apoptosis dna oxidative damage bone marrow cells early stage steroid induced femoral head japanese white rabbits randomly divided three groups steroid vitamin treated control groups comprising rabbits steroid group group initially injected twice intravenous dose escherichia coli interval two injections dose three times intervals order establish rabbit model vitamin treated group group received treatment group administered vitamin daily beginning modeling control group group injected normal saline equivalent dosage times aforementioned two groups two time points weeks following completion modeling selected verified histopathology hematoxylin eosin staining apoptosis rate analyzed terminal transferase end labeling assay apoptosis expression levels caspase cell lymphoma bcl dna oxidative damage bone marrow hematopoietic cells analyzed immunohistochemistry weeks following completion modeling bone rates group respectively lower results group apoptosis indexes group respectively lower results group addition bcl expression week femoral head tissues group higher compared group proportion bcl positive cells group higher compared group caspase staining data week femoral head tissues demonstrated femoral heads group four negative eight positive group five negative seven positive group negative one positive addition dna oxidative damage rate week bone marrow cells group lower compared group higher compared group vitamin effective apoptosis decreasing caspase expression bcl expression alleviating dna oxidative damage bone marrow cells early stage steroid induced femoral head necrosis rabbit models
despite popularity strategy video games poorly studied social science strategy video games require long gaming sessions planning management resources reaching long term goals assumed function virtual training center self regulation abilities every day life adopting strength model self control theoretical framework two cross sectional studies examined extent playing strategy video games predicts self regulation study found positive significant association strategy video game play controlling impact video game self regulation study relationship controlling effects personality traits individual preferences age gender satisfaction life avoidance need cognition risk taking big overall frequency exposure video games study playing strategy video games positively associated self regulation moreover relation statistically held controlling impact individual personality differences implications future directions discussed elsevier ltd rights reserved
factorization polynomials one foundations symbolic computation applications arise numerous branches mathematics sciences however present advanced programming languages support symbolic computation directly hence leads difficulties applying factorization engineering fields paper authors present algorithm use numerical method obtain exact factors bivariate polynomial rational coefficients proposed method directly implemented efficient programming language together multiple precision library addition numerical computation part often requires double precision easily
recent increase youth sports participation single sport youth athletes past years increase number acute overuse sports injuries population review focuses overuse traumatic injuries shoulder young athletes particular discuss little league shoulder internal rotation deficit instability superior anterior posterior lesions little league disease instability significant emphasis evaluation management upper extremity injury overhead
paper presents design test results excitation generator motor three phase stator salient pole excited rotor multiple flux barriers filled low cost permanent magnets new generator low voltage regulation obtained flux barrier combination field excitation low power control full power diode rectifier stator good power volume superior efficiency obtained costs comparable existing generator generator configuration principle equations finite element field analysis design optimization performance characteristics test results together generating system simulations constitute core paper
purpose study explore link political affinity source credibility perception cases news based third person perception framework study combines methodology focus group interviews investigate interaction audience source shaping credibility media source results confirmed third person perception tend perceive aligned news channel trustworthy fails attain social impact deserves contrast perceive hostile news channel social impact although trustworthy
studies mindfulness based stress reduction youth recently emerged shortage research adolescents clinical populations experience purpose qualitative study explore impact subjective perspective adolescents serious mental health concerns residential treatment center participated adapted week program learned range mindfulness skills encouraged apply skills everyday lives end program month follow youth participated semistructured interviews asked describe impact program perspectives basic qualitative analysis methods used code data group codes higher level themes main themes found including improved mood enhanced relationship self increased self control improved problem solving awareness present enhanced interpersonal relationships study suggest program perceived beneficial short term follow several aspects emotional cognitive interpersonal functioning
developing effective treatments preventing inflammatory bowel disease ibd urgent challenges improving patients health suggested platelet activation reactive oxidative species generation involved pathogenesis ibd examined inhibitory effects selective inhibitor two antioxidants modified alpha acid sodium induced colitis balb mice treated feed colitis induced administering drinking water days inhibitory effects substances evaluated measuring relevant clinical symptoms faecal blood diarrhoea body weight loss colon length plasma cytokine chemokine levels whole genome gene expression histopathology diarrhoea suppressed treatment prevented shortening colon length treatment groups exhibited decreased plasma levels interleukin tumour necrosis factor tnf alpha compared group microarray analysis showed cell adhesion cytoskeleton regulation cell proliferation apoptosis related inflammatory cell infiltration mucosal healing affected groups induced mucosal injuries mucosal loss inflammatory cell infiltration distal colon prevented antioxidant treatment results suggest anti inflammatory effects agents reduced induced mucosal injuries mice therefore provide therapeutic benefits ibd elsevier gmbh rights reserved
systematic ordinary occurrence daily lives since commonly assumed function memory remember past typically thought happen memory system paper argue cases due failures memory system particular argue many ordinary cases seen instances rather normal result larger cognitive system performs different function remembering just one operation building upon extant psychological evidence offer picture memory integral part larger system supports thinking case potentially case also case precisely claim remembering particular operation cognitive system permits flexible recombination different components encoded traces representations possible past events occurred service constructing mental simulations possible future events
report fabrication imaging quality optical smooth surfaces using carbon nanotubes embedded epoxy matrix epoxy multifunctional smart composite material sensing capabilities made incorporate self actuation moreover since precursor low density liquid large lightweight fabricated processes replication printing technology therefore holds promise development new generation lightweight compact smart figure sensing active adaptive figure control report measurements made optical mechanical characteristics discuss possible paths future development
knowledge genetic diversity population structuring represents key component conservation species especially introduction operations integral tools population management blue threatened specialist endemic new zealand populations north south island form two distinct mitochondrial lineages currently separate conservation management examine patterns variability microsatellite loci mitochondrial control region data assess range wide genetic diversity population structure blue data suggest north south island blue populations likely late limited gene flow strongly reinforcing current management strategy avoid translocation islands genetic diversity within islands follows pattern isolation distance relatively high levels gene flow among populations likely driven male juvenile dispersal overall genetic diversity blue low effective population size small data provide important information conservation management species
objective examine whether cumulative family discrimination stress months postpartum among mexican origin adolescent mothers mother figures predicted childrens socio emotional functioning academic achievement years age role maternal depressive symptoms mother child interactions association method mexican origin families adolescent mother child mother figure participated wave longitudinal study families recruited interviewed adolescent mothers pregnancy adolescent mothers mother figures children assessed annually next years using combination interview based survey observational methods maternal reports childrens socio emotional behaviors measured using child behavior checklist childrens academic achievement assessed iii tests achievement iii used results structural equation modeling revealed greater cumulative family discrimination stress pregnancy months postpartum predicted higher adolescent mothers depressive symptoms greater mother child intrusive interactions less mother sensitivity months postpartum maternal depressive symptoms positively related childrens symptoms months postpartum greater cumulative discrimination stressors directly predicted childrens lower test scores accounting socio economic status conclusion mexican origin adolescent mothers mother figures cumulative discrimination stress pregnancy childrens second predicted childrens socio emotional academic achievement age overall findings underscore cumulative impact stressors population substantial public health significance
cytokine interferon ifn alpha induces wide spectrum anti viral mediators via janus kinase signal transducer activator transcription jak stat pathway characterised ifn stimulated gene expression even though also activated ifn alpha role anti viral induction unclear several viruses including hepatitis reduce cellular protein levels via promotion ubiquitin mediated degradation viral immune mechanism suggests anti viral role ifn alpha signalling investigate functional involvement type ifn pathway first analysed effect upon replication two viruses influenza viral plaque assays using wild type murine embryonic fibroblasts revealed required inhibition influenza replication furthermore knockdown also enhanced influenza replication hindered induction several characterised anti viral expression effect upon induction separate group discoveries reveal first time anti viral role ifn alpha pathway characterise requirement expression specific findings also identify therapeutic target viral infection highlight essential pathway component endogenous therapeutic ifn alpha responsiveness
paper analyses whether chinas export export driven environmental concerns since china enforce environmental regulation trade policy used second best environmental policy general equilibrium model possible show second best export increases products pollution intensity empirical analysis investigates whether export equivalent partial export higher products pollution intensive along several dimensions results indicate rates set way water pollution intensive intensive energy intensive products moreover conservation natural resources minerals metals wood products seems key determinant chinas export rates little evidence export motivated environmental concerns author published elsevier inc open access article license http creativecommonsorg
field primary headaches cranial experienced relatively brief period progress expansion knowledge allowed partial machinery involved occurrence attacks identification set mediators genes likely play role case migraine accumulated evidence recently led development first disease specific prophylactic drug antibodies cases drugs available indications different pain toxin drugs tested adapted protocols proving effective chronic migraine showing potential efficacy cranial cluster headache trigeminal joint disorder scientific advances much research still needed fully understand effectively treat primary headaches cranial open issues manifold spanning pathophysiology clinical aspects represent exciting challenges future research
social environment modulates gene expression physiology behaviour patterns inheritance years concept investigated using approaches include partitioning social component behavioural heritability estimates studying maternal effects offspring analysing dominance hierarchies recent advances social environment effect providing nuanced approach study social influences behaviour recognizing evolutionary implications yet formulations dynamics social interactions accounted also individual behaviour group level interactions largely ignored consistent evolutionary theory principles social interaction conserved across broad range taxa diverse organisms review uses drosophila case study revisit known social interaction paradigms highlight benefits integrating history pattern interactions among individuals molecular mechanisms underlie social modulation behaviour
adverse relationship suboptimal fetal environments development adult diseases hypertension type diabetes cardiovascular disease reported numerous studies purpose study investigate strain difference response maternal malnutrition pregnancy involvement angiotensin system ras development adult hypertension using mice angiotensin type receptor associated protein transgenic mice pregnant dams fed diet containing either normal protein low protein protein birth weight significantly reduced offspring offspring arterial blood pressure higher offspring groups contrast offspring show increase blood pressure compared offspring renal angiotensin type receptor expression altered maternal malnutrition whereas angiotensin type receptor expression significantly decreased offspring conclusion findings suggest suboptimal intrauterine environment induces adult hypertension alteration expression ras components partly suppressed sustained overexpression via attenuation receptor mediated pathological response soc american society hypertension rights reserved
artificial hair sensors recently developed air force research laboratory using carbon deformation air flow causes voltage current changes circuit used quantify dynamic pressure aerodynamic load along wing surface done lot essential work design manufacturing measurement work paper bridge current work feasible applications flight dynamics control highly flexible aircraft highly flexible vehicle modeled using strain based nonlinear beam formulation coupled finite state inflow feedback control algorithm rejection perturbations developed simplified linear quadratic regulator controller implemented based state space representation linearized system measurements used control input wing sectional aerodynamic loads defined control output designing feedback gain controller designed closed loop aeroelastic simulations performed evaluate performance different controllers force feedback compared traditional controller designs state feedback study feasibility flight control assessed whole study facilitate building fly feel simulation environment autonomous vehicles
material known induce diabetes prior inducing prolonged diabetic state causes acute however precise primary target site mechanism remain unclear objective study evaluate morphological characteristics relevant acute renal toxicity following administration rats treated eight hours treatment negative pump positive thick limbs outer tubular lesions progressed outer cortex day treatment lesions reached peak proximal distal also showed degeneration necrosis tubular regeneration seen damaged tubular epithelium included slightly enlarged positive granules expressed transporter cytoplasmic mitochondrial swelling detected cells findings suggest initially causes degeneration induces mitochondrial cellular damage tubular epithelium without involving
renewable energy projects korea two avenues provide increase financial viability feed fits offer cost based prices renewable electricity compete conventional energy producers clean development mechanism issues certified emission reduction credits generate additional enhancing renewable projects return investment study investigated impact financial returns projects investment analysis performed four cases including solar hydropower wind landfill gas projects electricity sales fits compared using financial indicators measure relative contributions results indicate partial towards large scale projects high emission reductions moreover conflicts fit schemes small scale capital intensive projects registration analysis highlights bias particular project types part due towards carbon credit prices also reveals korea key susceptible biases demonstrated disproportionate distribution issued improving incentives small scale projects price differentiation excluding domestic testing proposed possible reforms
background womens health key factor affecting health whole population tackling inequality determinants health recognized main path toward reducing inequality health outcomes study aimed analyze inequality determinants womens health health care iran methods using model comprehensive framework determinants womens health including environment culture norms womens roles reproduction production health related mediators health outcome categories chose indicators using data sources including iranian multiple indicators demographics health survey national organization civil registration statistics centre iran analyzed inequality indicators iran coefficient curve used measuring inequality results coefficients calculated follows life satisfaction level women women proper knowledge hiv aids prevention women women without income women use least one type mass media women used computer internet women received pregnancy care skill birth women delivered help women currently smoke cigarettes women currently consume women least one chronic disease womens deaths respectively conclusions found large disparities determinants womens health iran determinants lifestyle health behavior health knowledge health care services availability considered health policymakers addressing inequality womens health level
energy use internal combustion engine passenger vehicles contributes directly emissions fuel consumption producing number air pollutants optimizing vehicle velocity utilising upcoming road information opportunity minimize vehicle energy use without requiring mechanical design changes dynamic programming capable optimization task shown simulation produce fuel savings average compared real driving data however paper also applied real time low cost computer situ vehicle test drive undertaken driver feedback provided dynamic programming algorithm results compared simulated intelligent control system follow algorithm results precisely reduction fuel loss time reported compared test driver
objectives master philosophy physiological sciences describe new ways anatomy biochemistry physiology one hand microbiology pathology pharmacology hand meet functional requirements multidisciplinary integrated concepts elucidate relationships cell biology molecular biology molecular genetics connecting dots cell functions driven molecules controlled genes forms basis cell molecular genetics module upon multidisciplinary modules physiological sciences follow credit hours provide physiological basis studies faculty development enhance learning abilities medical student modules constitute respiratory physiological sciences renal physiological sciences reproductive physiological sciences integrated microbiology pathology pharmacology unique way microbes leading associated pathology mechanisms prescribed drugs additional thesis friendly course work leading comprehensive examinations year two deals research work credit hours leading defense thesis physiological sciences fundamentally different offered elsewhere offers good spring board studies faculty institutional development first study deals innovative programmes research learning education field physiological sciences broad based make recipients competent critical confident productive learner completely unique design curriculum comparable examples elsewhere mission educate graduate students field physiological sciences complete grasp broad based integrated concepts basic health sciences upon completion education students able use hence students contribute fields creative energy
novel bias scheme realizing low voltage second order loops introduced paper provided design examples include current geometric mean multiplier cells performed comparison shows derived analog signal processing blocks offer reduced circuit complexity improved performance compared corresponding already published counterparts
objective identify effective mind body exercise programs provide clinicians patients updated high quality recommendations concerning non traditional land based exercises knee osteoarthritis methods systematic search adapted selection criteria included comparative controlled trials mind body exercise programs patients knee osteoarthritis panel experts reached consensus recommendations using delphi survey hierarchical grading system used based statistical significance clinical importance improvement results four high quality studies identified demonstrated various mind body exercise programs promising improving management knee osteoarthritis demonstrated significant improvement pain relief grade physical function grade chi demonstrated significant improvement quality life grade pain relief grade physical function grade sun style chi gave significant improvement pain relief grade physical function grade conclusion mind body exercises promising approaches reduce pain improve physical function quality life individuals knee osteoarthritis
large superfamily enzymes identified make use radical intermediates derived cleavage primary nature radical intermediates makes highly reactive potent used initiate hydrogen atom abstraction process allows particularly diverse range substrates functionalized including substrates relatively chemical structures first part review discuss evidence supporting mechanism radical formation second part review examine potential reaction products arising cause product inhibition effects product inhibition kinetic studies radical enzymes discussed strategies overcome issues reviewed article part special issue entitled radical sam enzymes radical enzymology elsevier rights reserved
important factor solar energy transformation electrical chemical energy using nanoparticles based devices spatial location limiting electron transport evidences presented indicating electron diffusion strongly influenced nanoparticle boundaries whose characteristics depend particles preparation present work studied role excess proton structures formation nanoparticles boundaries samples prepared hydrolysis low temperature strong acidic conditions samples constituted mainly amorphous studied mas nmr results indicate excess proton species generated bridging highly defective amorphous chains favor chains bonding nanoparticles condensation nanoparticles surface chains bonding facilitates particles aggregation producing oriented self preparation conditions determine strong condensation amorphous chains favor transformation elsevier rights reserved
department primary industries delivered farms project australian governments water future initiative project provided irrigation management training infrastructure upgrade licensed river potable water peri urban areas basin securing water savings preventing export nitrogen phosphorus annually greenhouse vegetable producers region mostly culturally diverse communities enterprises small tight flows uncertain land due potential expensive water efficient infrastructure filtration systems presented major barrier technology uptake address barriers extension team decided two approach utilised demonstration farms basic low cost technology rainwater harvesting tanks high high cost recycling systems copper ultra filtration systems concurrently services independent engaged assess water savings potential options demonstration sites assisted increasing uptake recycling projects potable water savings per per site along significant reductions nitrogen phosphorus export catchment area financial analysis greenhouse vegetable recycling project sites shown payback period two years overall project provided valuable data lessons help developing water management strategies long term water security river health peri urban landscapes
study describes analysis design improved recycling folded cascode using new input path positive feedback simultaneously increases transconductance considerably proposed amplifier bias circuits circuit simulated tsmc circuit simulator according simulation results proposed circuit shows mhz gain power dissipation respectively demonstrates gain enhancement mhz improvement comparison recycling folded cascode capacitor load power dissipation finally monte carlo simulations performed verify robustness proposed circuit versus process temperature supply voltage device dimension mismatch variations
system identification problems impose constraints parameters estimated due inherent physical characteristics unknown system least mean square algorithm variants allow one address problem online manner least mean fourth algorithm recently proposed improve performance algorithms cases measurement noise gaussian paper provides first theoretical analysis stochastic behavior algorithm stationary gaussian inputs slow learning simulation results illustrate accuracy proposed analysis elsevier rights reserved
understanding intent relevance surrounding agents video essential task many applications robotics computer vision modeling evaluation contextual spatio temporal situation awareness particularly important domain intelligent vehicles robot required complex environment also interacting humans paper address issues studying task road object importance ranking video first human centric object importance annotations employed order analyze relevance variety multi modal cues importance prediction task deep convolutional neural network model used capturing video based contextual spatial temporal cues scene type driving task object properties related intent second proposed importance annotations used producing novel analysis error types image based object detectors specifically demonstrate cost sensitive training informed object importance annotations results improved detection performance objects higher importance insight essential application navigation safety critical quality automation human robot interaction key
complex software development projects rely contribution teams developers required collaborate coordinate efforts productivity development teams size related produced output important consideration project schedule management cost estimation majority studies empirical software engineering suggest due coordination overhead teams developers become less productive grow size phenomenon commonly law software project management states adding software project makes later outside software engineering non additive scaling productivity teams often referred effect studied extensively social psychology organizational theory conversely recent study suggested open source software projects productivity developers increases team grows size collective effects surprising finding linked whole sum parts using data set projects contributed developers article provide large scale analysis relation size productivity software development teams findings confirm negative relation team size productivity previously suggested empirical software engineering research thus providing quantitative evidence presence strong effect using fine grained data association developers source code files investigate possible explanations observed relations team size productivity particular take network perspective developer code associations software development teams show magnitude decrease productivity likely related growth dynamics editing networks interpreted first order approximation coordination requirements
growing energy demands environmental degradation uncontrolled exploitation fossil fuels world look alternatives context biogas promising candidate easily utilized engines decentralized power generation applications primary constituents raw biogas methane defines heating value carbon dioxide acts like dilution effect reduces flame speed heating value biogas eventually engine performances present article focuses experimental evaluation quantification variations engine performance three compositions biogas containing volume respectively studied small engine dual fuel mode moreover evaluate individual process exergy analysis based second law thermodynamics implemented exergy different compositions biogas presented biogas dual fuel operation showed diesel substitution lower engine loads higher loads total engine increased diesel operation biogas compositions respectively furthermore combustion found decreasing higher concentrations biogas showed comparable results diesel operation second law efficiencies respectively elsevier ltd rights reserved
background assessing related effects lung volumes derived body limited aimed evaluate effect size lung volumes including assessment body relationship functional capacity impact corrective surgery three patients years female large deviation intra thoracic stomach type iii respiratory function data body capacity underwent surgery respiratory function analysed relation size groups iii respectively functional capacity post operative changes quantified subgroup lung capacity vital capacity correlated inversely size predicted groups iii respectively predicted however mean values normal abnormal lung volumes surgery increased predicted decreased residual volume total lung capacity ratio respiratory changes modest relative marked functional class improvement among parameters improved following surgery decreased forced volume increased ratio correlated poorer functional class pre size correlates reduced surgery improves lung volumes gas trapping however changes mild within normal range
introduction subjective cognitive decline indicate preclinical alzheimers disease existing literature heterogeneous approaches studying assessed differential cognitive affective neuroimaging correlates two aspects reporting high cognitive difficulties self rated questionnaire versus memory clinic methods compared patients memory clinic isolated community recruited similarly high levels self reported cognitive difficulties community recruited controls low self reported cognitive difficulties results increased anxiety amyloid beta deposition observed groups high self reported difficulties whereas subclinical depression hippocampal atrophy specifically associated medical help seeking cognitive tests showed group differences discussion results validate concept community clinic based groups yet recruitment methods influence associated biomarkers affective symptomatology highlighting heterogeneous nature depending study characteristics alzheimers association published elsevier inc rights reserved
studying interplay peptide major source secondary metabolites crucial external modifying enzymes challenging task since interactions involved often transient nature applying range synthetic inhibitor type compounds stabilized complex appropriate structural analysis generated tailoring enzyme domain complex studied comprises carrier protein domain bound cytochrome enzyme crucial provision beta amino acid precursors biosynthesis cyclic structure reveals complex formation governed hydrophobic interactions presence controlled minor alterations structure enable selectivity amongst multiple highly similar domains
ambient vibration measurement output data dynamic testing natural excitations represented instance modal identification involving output measurements requires use specific modal identification techniques paper presents application reliable method stochastic subspace identification implemented general purpose software criterion toward robustness identified modes bio inspired optimization algorithm highly nonlinear objective function introduced order find optimal deployment reduced number sensors across large civil engineering structure validation modal identification bridge one longest cable stayed bridges situated hong kong chosen case study results show proposed method eigenvalues even reduced number sensors without significant loss accuracy
rapid sensitive selective accurate method developed quantitative determination levonorgestrel lng rat plasma validated specificity linearity accuracy precision sensitivity matrix effect recovery efficiency stability liquid liquid extraction procedure using ethyl acetate mixture ratio employed efficiently extract lng rat plasma reversed phase column installed triple system used perform chromatographic separation lng identified within min high specificity linear calibration curve drawn within concentration range developed method validated intra day inter day accuracy precision whose values fell acceptable limits matrix effect found minimal recovery efficiency three quality control concentrations low medium high found stability lng various stages experiment including storage extraction analysis evaluated using samples results showed lng stable conditions validated method successfully used study pharmacokinetics lng rats injection providing applicability relevant preclinical studies elsevier rights reserved
paper mainly studies image contour detection algorithm distinguish edges different strengths based study probability boundary operator find defects response suppression offset exist algorithm detection curved edges thus improved algorithm proposed algorithm advantage probability boundary algorithm effectively distinguish edge strength improves mentioned defects improved algorithm proposed characterize strength boundary reasonably making test results line human subjective recognition results
aim review provide current state knowledge usefulness modern genetic technologies causality isolated multiple congenital anomalies array comparative genomic hybridization next generation sequencing revolutionized clinical approach patients phenotypes technologies enable early diagnosis especially clinically challenging newborn populations help uncover genetic defects associated various phenotypes application complementary methods assist identifying many variants simultaneously involved development number isolated multiple congenital anomalies technologies carry serious variant risks therefore methods variant classification accessible variant databases mentioned useful strategy clinical genetic testing application methodologies presented finally future directions challenges briefly review
automated computer vision based fire detection gained popularity recent years every fire detection needs fast accurate paper new fire detection method using image processing techniques proposed explore create fire flame based colour space via linear multiplication conversion matrix colour features sample image show matrix multiplication result differentiating colour space fire part highlighted non fire part particle swarm optimization pso sample pixels image used obtain weights colour differentiating conversion matrix provides fitness metric pso procedure obtained conversion matrix used fire detection different fire images without performing pso procedure allows fast easy fire detection system empirical results indicate proposed method provides qualitatively quantitatively better results compared conventional state art algorithms elsevier ltd rights reserved
retina tagged part brain due common embryonic origin appears promising site investigation psychiatric disorders retinal function assessed best obtained large sample patients major depressive disorder matched controls cone rod response functions recorded non eyes major depressive disorder patients mdd controls mean age respectively amongst mdd patients drug free mean age patients cone level prolonged wave observed drug free patients prolonged wave discovered averaging implicit time highest wave amplitudes patients mixed wave reduced whereas trend observed pure rod wave reduced mixed reduced prolonged drug free patients similar pattern observed terms effect sizes overall drug free mdd patients deficits suggesting anomalies present beyond effect medication interest prolonged cone reduced rod amplitude reported group schizophrenia patients suggesting common neurodevelopmental root major psychiatric disorders published elsevier inc
enzymatic characterization four group nucleotide disulfide performed focus coa dependent nad elemental sulfur nad oxidase nox activities exhibited activity preference nadph showed strict coa dependency similar assays non enzymatic formation free coa observed addition enzyme nadph enhanced evolution catalytic cycle proposed suggesting coa acted forming coa followed reduction enzyme coa intermediate produced enzymatic non enzymatic evolution coa nadph electron donor showed activity independently coa implying direct reaction exhibited high nox activity dependent activities inhibited addition free coa multiple disruptions four group demonstrated none essential dependent growth many grew better parent strain multiple showed decreased growth properties aerobic inoculation pyruvate containing medium without suggesting complicated participation group sensitivity resistance dissolved oxygen absent
previous research showed vertical modulate human mood examined possibility using memory recognition task positive negative neutral emotional images high low arousal levels images remembered participants visual task later presented together novel images vertical inducing neutral visual stimuli results showed downward facilitated recognition negative images inhibited recognition positive ones memory task provide additional evidence influence cognitive emotional processing also provide new paradigm used future embodied cognition research
paper electrical analogous models fractional hereditary materials introduced based recent works authors mechanical models materials behavior firstly approached using fractional mathematical operators viscoelastic models elastic viscous components obtained combining springs various arrangements elements used viscoelastic models modeled electrical circuits spring analogous capacitance resistance respectively proposed models validated using modal analysis moreover comparison numerical experiments based finite difference time domain method shows long time simulations correct time behavior obtained modal analysis use electrical analogous better reveal real behavior fractional hereditary materials elsevier rights reserved
evidence reviewed supporting presence inherited structural defect plasma membranes somatic cells humans type diabetes mellitus sodium sensitive essential hypertension magnesium binding defect consists decreased content tightly bound ion cell membrane limits amount cell combines atp produced cell form metabolic energy consequently overt diabetes intracellular concentration ions significantly less normal ions required substrates enzyme systems human metabolism many involved insulin thus decreased activities particular ones enzyme systems due decreased intracellular dependent responsible insulin resistance decreased insulin secretion production physiological processes required occurrence type diabetes mellitus processes account morbid symptoms associated disease thus decreased intracellular concentration ions constitutes etiology genetic predisposition type diabetes mellitus corrected identified peptide binding promoters derived terminal substance occur normal blood plasma decreased intracellular also result dietary deficiency magnesium abnormal accumulation saturated fatty acids cell membranes inhibits entrance cell thus also etiology diabetes caused magnesium deficiency also type diabetes mellitus although pathologies corrected binding promoters corrected respectively dietary magnesium supplementation exercise plus dietary caloric lipid restriction theoretically disease syndrome containing type diabetes mellitus involve approximately population
aim study examine differences neural processing social information friends different levels social network level twenty five female participants engaged cognitive social task involving different individuals social network undergoing functional magnetic resonance imaging scanning detect blood oxygen level dependent signals changes greater levels activation occurred several regions brain previously associated social cognition thinking friends thinking including posterior cingulate cortex ventral medial prefrontal cortex linear parametric analyses across network layers showed came thinking friends activation increased gyrus sensorimotor cortex individuals thought friends closer layers network findings suggest maintaining cognitively maintaining relationships
study examined whether victimization associated negatively distorted social cognition bias specific increased sensitivity social negative cues assessing perception social exclusion consequences psychological wellbeing fundamental needs self reported peer reported victimization participants age years girls measured social exclusion manipulated inclusion versus exclusion virtual ball game childrens perceptions psychological general negative exclusion inclusion moreover self reported peer reported associated perception excluded receiving ball less negative less fundamental needs regardless excluded included game contrast peer reported victimization associated negative mood lower need exclusion condition together results suggest children indicate negatively distorted social cognition whereas children according peers experience increased sensitivity negative social situations results stress importance distinguishing self reported peer reported victimization implications interventions aimed childrens social cognition elsevier inc rights reserved
new systematic design procedure square root domain domain circuits based signal flow graph sfg synthesis approach introduced paper sfg prototype system modified using proposed set operators way domain building blocks used corresponding implementations purpose new domain integrator circuits proposed constructed new current mode geometric mean multiplier circuits main advantages proposed circuits accuracy due immunity body effect low circuit complexity potential low voltage operation example fifth order low pass filter designed using proposed technique simulation results confirm validity proposed design technique high performance proposed circuits
numerical aspects central importance identification control many computations fields involve approximations using polynomial rational functions obtained using orthogonal projections aim paper develop new general theoretical framework solve large class relevant problems proposed method built introduction polynomials respect data dependent linear form linear form conventional inner product allows asymmetric problems proposed approach shown lead optimal numerical conditioning kappa recent frequency domain instrumental variable system identification algorithm comparison shown recent algorithms exhibit extremely poor numerical properties solved using traditional approaches
aim article design implementation intelligent irrigation devices using arduino microcontroller control interface irrigation system created mobile application currently existing various similar solutions perspective money present solution cheap effective especially home usage following extension also applied larger scale buildings greenhouse intelligent others used hardware components realization microcontroller arduino real time clock two humidity sensors valves application controlling irrigation device using mobile technology created programming language java easy smart irrigation system controlled smart phone tablet operating systems android reactions functions proposed intelligent system verified statistical results evaluated using analysis non parametric test analysis determine reliability irrigation equipment clarify behavior system existence systematic random errors
many efforts devoted modeling impedance conjugated polymer based actuators using equivalent electrical circuits employing methodology based mechanical sensors also treated equivalent transmission line circuit overall impedance modeled correspondingly due large number resources study electrical circuits technique practical tool therefore study equivalent circuit model including electrochemical parameters determined obtain better perception sensing mechanism mechanical sensors conjugated polymers capable generating output current voltage upon induced mechanical deformation force observed behavior polymer based mechanical sensors considered reverse actuation process many outstanding properties conjugated polymer actuators including light weight biocompatibility still retained sensors sensors configuration capable operating air response mechanically induced bending deformation however due nonlinear behavior multivariable characteristics required propose systematic approach order optimize performance gain optimal values constituent decision variable therefore proposed mathematical model used define output voltage based mechanical sensor along sensitivity model applied frequency induced deformation applying multiobjective optimization algorithm optimization problem solved tracking ability proposed model verified
present study evaluated response bias scale symptom validity test embedded within personality inventory form assesses neurocognitive complaints sample stand trial criminal additionally examined failure scale performance validity test embedded within structured interview reported symptoms second edition similarly assesses cognitive impairment results indicated area curve auc scale auc achieved moderate classification accuracy using test memory criterion scale appeared useful screening presented genuine specificity respectively less effective classifying suspected according sensitivity respectively order identify significant proportion impairment considerably lower cutoff scores recommended measures manual evaluated score sensitivity specificity scale raw score sensitivity specificity required achieve sensitivity alternate cutoff scores therefore useful screening inpatient forensic psychiatric scales effectively predicted classification combination although significantly contributed model implications assessment forensic psychiatric settings discussed
atypical visual perceptual skills thought underlie unusual visual attention autism spectrum disorders assessed whether individual differences visual processing skills scaled quantitative traits associated broader autism phenotype visual perception assessed using figure ground test visual perceptual skills edition large adult cohort figure ground scores positively correlated autistic like social features assessed broader autism phenotype questionnaire relationship gender specific males showing correspondence visual perceptual skills autistic like traits work supports link atypical visual perception autism highlights importance characterizing meaningful individual differences clinically relevant behavioral phenotypes
attention basic cognitive function necessary daily activities beneficial effects cognitive abilities exposure nature reported explore relaxation nature differently affect directed attention physiological measures participants women measured directed attention pattern control test guided progressive relaxation session nature additionally systolic diastolic blood pressure heart rate measured relaxation participants environmental preference explored main result showed environmental effect directed attention favour natural environment similar environmental effect physiological measures seen results indicate relaxation natural environments positive effect directed attention hence important component preventive interventions stress related symptoms
today huge amount tables presented web pages word documents many unstructured data intended understood humans interpreted machines time often need information structured form relational databases propose rule based approach table analysis interpretation demonstrate applied transform data unstructured structured relational databases form paper discusses representing data facts working memory rule engine formal language defining rules table analysis interpretation implementation
paper provides review key concepts concurrent design different machine types suitable self sensing zero low speed high speed operation impact modifying machine design suitable self sensing power conversion properties average ripple torque presented several classical advanced machine types general recommendations yield self sensing performance good power conversion properties provided induction machines surface permanent magnet machines flux interior permanent magnet machines variable flux machines variable magnetization state variable leakage flux
active appearance models one popular established techniques modeling objects computer vision paper study problem fitting using gradient descent algorithms present unified complete view algorithms classify respect three main characteristics cost function type composition iii optimization method furthermore extend previous view proposing novel bayesian cost function interpreted general probabilistic formulation known project loss introducing two new types composition asymmetric bidirectional combine gradients image appearance model derive better convergent robust algorithms providing new valuable insights existent algorithms direct applications complement method finally order encourage open research facilitate future comparisons work make implementation algorithms studied paper publicly available part project http
purpose goal study compare international prostate symptom storage active bladder symptom score tools assessing symptoms overactive bladder oab methods cross sectional study conducted sample patients aged years older lower urinary tract complaints undergone medical examination one several centers patient reviewed international prostate symptom score patients divided groups according result group score group score another groups according diagnosis group oab patients group non oab patients determined whether varied statistically significant extent groups furthermore evaluated correlation severity results group oab diagnosis rate compared groups results groups results found vary statistically significant extent group significant correlation found severity results prevalence analysis statistically significant difference found among groups receiver operating characteristic curve showed area curve conclusions results cross sectional analysis suggest significantly correlated although scores used measure oab symptoms simultaneous use warranted
systematic review literature predictors moderators mediators outcome following cbt eating disorders sixty five articles included relationship individual variables outcome separately across diagnoses treatment format early change found consistent mediator better outcomes across eating disorders moderators mostly tested binge eating disorder moderators affect cognitive behavioural treatment outcome relative treatments consistent predictors emerged findings suggest unclear treatment works research testing mediators moderators needed variables selected analyses need empirically theoretically driven future recommendations include need authors interpret clinical statistical significance findings use consistent definition outcome studies directly compared iii report null statistically significant findings copyright john wiley sons ltd eating disorders association
attack angioedema frequently occurring disorder especially adults appear without idiopathic accompany disorders allergic including ige related histamine major mediator non ige related mediated mediators allergic angioedema food insect drug allergic focal infection often corticosteroids drugs effectively removing symptoms angioedema contrast allergic one usually induced bradykinin type angioedema grows slowly accompanied reach large size spontaneously days bradykinin mediated angioedema consequence hereditary acquired deficiency inhibitor hyperactivity factor appear also intake drugs decrease inactivation bradykinin resistant corticosteroids drugs requires treatment inhibitor drugs inhibitor receptor bradykinin fresh frozen plasma bradykinin angioedema presents subcutaneous external angioedema membrane internal organs usually airways digestive system bradykinin angioedema airways fatal requires immediate efficient medical treatment however bradykinin angioedema digestive system also dangerous due shock due intestine occlusion
present study examined moderating effect cigarette smoking status relation anxiety sensitivity fear expected negative consequences anxiety bodily hazardous alcohol consumption sexual suicidality series multiple hierarchical regressions used test proposed hypothesis among sample persons living hiv aids usa male age fifty seven percent participants reported past month smoking results indicated reported smoking higher anxiety sensitivity demonstrated highest rates hazardous alcohol use sexual suicidality simple slope analyses indicated anxiety sensitivity associated higher rates hazardous alcohol use sexual suicidality among individuals reported past month smoking among individuals smoke present results suggest smoking status relation anxiety sensitivity hazardous alcohol use sexual suicidality among persons living hiv aids data add growing literature suggesting smoking negative impact among persons living hiv aids extends beyond physical health problems variety clinically significant behavioral health sequelae
manufacturing cost analysis becoming increasingly important tool industry identify research areas need attention enable progress towards cost reduction targets describe method estimate manufacturing cost suitable use early stage technology development delivering manufacturing cost estimate uncertainty analysis quickly highlights opportunities greatest cost improvement apply technique three process sequences large scale production organic inorganic hybrid photovoltaic modules process sequence combines two demonstrated module sequences estimated cost uncertainty range comparable commercial crystalline silicon cadmium technologies basis cost electricity calculation shows technology competitive photovoltaic technologies module power conversion efficiency lifetime years achieved analysis shows even cost active layers electrode reduced zero module power conversion efficiency lifetime years required meet cost electricity targets copyright john wiley sons ltd
context fibroblast like rheumatoid arthritis display pathogenic behavior various members wnt pathway especially canonical wnt catenin cascade contribute autonomous activation shown two wnt inhibitors contribute several critical aspects joint biology however effects poorly characterized aim study investigate effects markers wnt components target expression compare findings methods treated days wnt signaling components catenin wnt target cyclin markers analyzed using western blotting qrt data indicated regulated key gene catenin decreased known downstream effectors gene wnt catenin pathway expression induced increased expression affect levels hand increased expression decreased expression results confirm involvement wnt signaling transformation show two inhibitors cascade regulate differently elements single inhibitor initiate signaling depending cellular fibroblast like rheumatoid arthritis wnt low density lipoprotein receptor protein inducible signaling pathway protein secreted related proteins osteoarthritis modified medium fetal bovine serum phosphate buffered saline sds page sodium sulfate polyacrylamide gel electrophoresis enhanced detection solution qrt pcr quantitative real time polymerase chain reaction standard deviation cysteine rich domain methyl cpg binding protein rankl nuclear factor kappa ligand
today manufacturers fully leverage potential computer aided engineering design machine tools production machines common design tools drive systems machine components build algebraic system description however dynamic quality criteria significant impact achievable accuracy productivity evaluated purely algebraic descriptions generally dynamic criteria incorporated signal oriented models control engineering modeling process time consuming knowledge intensive models limited paper presents methodology simplify optimization machine components feed drives taking dynamic quality criteria account method based object component oriented modeling language quick development models limited expert knowledge models integrated extensible model library modern mathematical optimization methods support systematic search combination system components parameters regards defined quality criteria therefore different design alternatives quickly analyzed compared authors published elsevier
antimicrobial resistance increases health social economic impact areas state regional local initiatives try contain problem resistance arise update year study microbiological epidemiological clinical aspects multi resistant bacteria resources therapeutic approach ancient modern drugs therapeutic combinations optimization programs case fungal infection analyze clinical scenarios different species yeast new clinical settings fungi taking paediatric population differences adults invasive fungal infection compared finally field treatment severe malaria imported resistant drugs reviewed
cell culture models hepatitis virus hbv remain mainstay screening testing efficacy anti hepatitis virus agents gradient based followed southern blotting used hepatitis estimation cell culture method several limitations report development assay using commercially available elisa plate followed real time pcr quantification hepatitis cell cultures assay rapid highly sensitive copies reaction highly specific associated dna addition assay requires allowing scaling
background risks early growth becoming overweight adulthood widely studied humans however early life predictive factors canine adult overweight obesity yet studied identify factors help explain development overweight obesity adulthood dogs longitudinal study years conducted female dogs age sexual status raised identical environmental conditions means hierarchical classification principal components following quantitative values fat free mass percentage fat mass pelvic circumference years age three groups dogs established named ideal weight slightly overweight overweight aim identifying predictive factors development obesity adulthood parental characteristics growth pattern energy balance plasma factors analysed logistic regression analysis results months group compositions line body condition scores values groups logistic regression analysis permitted identification neonatal growth rate first weeks life months predictors development obesity adulthood seventy percent dogs either months belonged group results energy intake expenditure corrected showed greater positive energy imbalance months compared group conclusion study expands understanding previously reported risk factors overweight obese dogs establishing studied dogs became overweight months age used predictive factors overweight adult dogs group higher values compared groups dogs
potential influence violent video games youth violence remains issue concern psychologists policymakers general public although several prospective studies video game violence effects conducted none employed validated measures youth violence considered video game violence effects context influences youth violence family environment peer depressive symptoms current study builds upon previous research sample female mostly hispanic youth results indicated current levels depressive symptoms strong predictor serious aggression violence across outcome measures depressive symptoms also interacted antisocial traits antisocial individuals depressive symptoms inclined toward youth violence neither video game violence exposure television violence exposure prospective predictors serious acts youth aggression violence results put context data serious acts violence among youth
field remote laboratories developed years laboratories valuable educational tools allow students faculty interact real equipment internet physically front system remote laboratory developed many technical difficulties found mainly respect links different elements physical system database clients work analyze challenges propose approaches develop remote laboratories achieve flexibility scalability greater educational value particular present remote laboratory automatic control includes electro pneumatic classification cell architecture laboratory based three architecture physical system layer server layer client layer client layer implemented web standards clients interact system using content management system communication interface physical system database uses middleware based process control engineering students regularly used remote laboratory evaluated surveys elsevier ltd rights reserved
depletion global address pool made deployment new version internet protocol inevitable paper transition mechanisms first phase deployment surveyed plus solution found appropriate important free open source implementations selected bind test environment testing method described first three selected implementations tested linux whereas tested linux performance characteristics response time number answered requests per second cpu memory consumption measured compared effect hardware architecture test computer also examined using single core dual core core test computers stability tested solutions analyzed overload conditions test used production environments strong response time requirements measurement results show significant differences performance tested implementations served four times requests per second executed single core cpu linux load generated eight clients however absolute order determined influenced different factors architecture hardware especially number cores bind therefore profit multiple cores also operating system server significant influence performance implementations certain conditions details measurements disclosed results presented paper easy use implementation selection guide also provided short summary high number results
integration digital technologies institutions higher education profoundly influencing formal learning global scale social models fully online learning positioned address demands government economic social development organizations engaged individuals strong problem solving critical thinking collaboration competencies established record performance university ontario institute technology canada fully online learning community one model paper response several including aforementioned demand greater educational focus higher order competency development deficiencies distance education learning models quest new learning models strengthen skills experience divergent community inquiry model describes collaborative learning social cognitive interactions amplified effective use synchronous asynchronous digital furthermore models learning communities reduce distance learners educators incorporates authentic assessment encourages technology cognitive outcomes responsibility constructive positioned conceptually addressed current limitations research agenda extending empirical foundations leveraging presented underlying argument self regulating learning communities established sustained fully online environments communities produce diversity beneficial learning outcomes functioning learners social contexts
recently mobile applications emerged smartphone trend now days huge number mobile operating systems require developments order achieve open source cross platform mobile frameworks came order allow code various operating systems paper focus made commonly used mobile development methods process suitable solution particular need proposed eventually new framework helps choose appropriate approach tool respectively suggested according convenient survey based binary questions addition certain criteria
nuclear envelope piece engineering one hand built like systems reinforcing membrane walls double membrane structure forming lumen like hand structure adapt maintaining integrity like bending river like nuclear pore complexes also mechanical means communication enabled largely complex multi protein structure intermediate across lumen double membrane nuclear envelope multiple cytoplasmic systems act simultaneously like like lines suspension bridge although many details greater structure remain number recent findings giving clues structural organization yield striking dynamic yet stable properties combining double triple helical coils intrinsic disorder order tissue specific components intermediate enables unique properties federation european biochemical societies published elsevier rights reserved
several challenges found current applications building information modelling model bim technology large scale mechanical electrical projects huge modelling workloads models details potential supporting cooperative construction management multiple participants insufficient functions intelligent facility management paper proposes multi scale solution address current applications construction facility management projects particularly practical multi scale bim consisting several macro micro scale information models described detail required information components according schema industrial foundation classes based model paper presents bim based construction management system provide virtual construction scenes appropriate scales various participants communicate bim based facility management system share information delivered previous phases improve efficiency safety management operation maintenance period application real world terminal illustrates proposed model two systems support collaborative construction management facility management multi scale functionalities among participants paper proposes series feasible models techniques promote bim application large projects elsevier ltd rights reserved
birth recognized physical psychological stressor many women practices birth meet womens needs maintaining safety optimize experience family centered birth package interventions encourages woman participate choosing interventions helpful undergoing planned unplanned birth included family centered birth implementation skin skin care operating room neonates appear term healthy process attempting implement family centered birth one academic center presented including steps implementation benefits challenges areas continued improvement research article part special series articles address innovations clinical practice education collaboration health policy global health american college nurse
multi organ mimic tissue tissue interactions occur result metabolite travel one tissue tissues vitro systems capable simulating human metabolism including conversion pro drug effective metabolite subsequent therapeutic actions toxic side effects since tissue tissue interactions human body play significant role determining success new pharmaceuticals development use multi organ present opportunity improve drug development process devices potential predict potential toxic side effects higher accuracy drug expensive phase clinical trials estimate efficacy dose response multi organ also potential aid development new therapeutic strategies providing platform testing context human metabolism opposed animal models operated human biopsy samples devices gateway development individualized medicine review studies multi organ developed used ways demonstrate devices capabilities present unique opportunities study drug action also discuss challenges inherent development among design devices create devices mimic human metabolism high since single organ devices testing platforms tissues later combined tissues within multi organ devices also single organ devices appropriate discussion elsevier rights reserved
psoriasis chronic inflammatory skin disease marked hyper proliferation aberrant differentiation keratinocytes affects worlds population research pathogenesis psoriasis hampered lack models accurately reflect biology psoriatic phenotype previously reported east indian oil significant anti inflammatory properties skin models hypothesized provide therapeutic benefit psoriasis patients due anti inflammatory anti proliferative properties present results going proof concept phase clinical trial applied demonstrating tolerated helpful alleviating mild moderate psoriasis symptoms led evaluate ability affect psoriatic phenotype using psoriatic normal human skin models impact phenotype normal skin tissue model however treatment psoriasis tissue model psoriatic pathology demonstrated histologic characterization expression keratinocyte proliferation markers phenotypic affects correlated suppressed production mcp csf beta demonstration ability psoriasis symptoms characterized vitro psoriatic tissue models supports hypothesis clinically observed symptom due suppression intrinsic tissue inflammation reactions lesions study presents systematic approach study underlying mechanisms cause psoriasis presents data supporting potential new therapeutic concept help direct accelerate development effective therapies
background purpose inverted mandibular distraction sequence useful technique avoiding injury tooth root inferior alveolar nerve identification understudied decrease complications study aims map position mandible compare location relative normal retrospective cohort study symptomatic patients three dimensional scans reviewed relative position study includes patients controls average measurements versus control vertical height versus width versus horizontal length versus angle degrees versus degrees horizontal position versus vertical position versus ratio along axis versus controls along axis ratio versus conclusions compared normal controls greater vertical height lesser horizontal length lesser angle greater patients analyzed proportions along height width vertical statistical difference position patients normal controls
paper presents rational approximation method fractional calculus operators alpha given frequency range error based best rational approximation definition fractional integral operator selected example describe construction rational approximation functions application case used illustrate effectiveness proposed method obtained approximation function frequency domain best rational approximation function improve accuracy approximation without increasing orders basis presented rational approximation method rational approximation equation fractional order pid controller obtained finally method analyzing optimization frequency characteristics fractional order controller implemented demonstrate good frequency characteristic best structure results theoretical analysis experimental verification show proposed method provides new design idea effective application fractional order pid controller engineering
introduction diabetes growing prevalence internationally individuals require insulin part treatment technology evolves optimize delivery improve adherence reduce dosing errors insulin outperform simplicity dosing accuracy user preference improve dosing confidence treatment adherence system offers novel approach treatment via wireless mobile application featuring enabling convenient insulin dose tracking accurate advice among features areas covered existing technology insulin delivery advice reviewed mechanics functionality device delineated findings testing usability studies system reported future directions system treatment diabetes discussed expert opinion diabetes management complex largely data driven system offers promising new opportunity insulin users features known improve treatment efficacy otherwise primarily available using pumps given majority insulin users use insulin pumps system improve glucose control significant portion diabetes population
crime victims emotional display legal settings found influence credibility judgments specific nature public expectations crime victims emotional responses however adequately investigated experimental study respondents community sample estimated likelihood female male victims experience distinct emotions response types crimes across crime types female victims expected experience significantly situation focused anxiety fear focused guilt shame sadness emotions significantly less focused emotions anger male victims calls increased focus distinct emotions future research victims emotions implications victims legal social settings discussed
tropical home developing countries traditional land use system contributes basic food requirements farming families providing small important income throughout year home rely rain survival systems present home neglected due social environmental problems among issues scarcity water cropping seasons important issue adversely affects crop production home mainly due occurrence unexpected dry periods cropping seasons requirement water source farmers residence home dry capture roof runoff home subsequent use appropriate green option mitigate situation rainwater tanks promoted used collect roof runoff water wet periods enabling home crops dry periods field experiments carried research farm obtain roof runoff coefficients commonly used roof types namely either woven leaves objective case study develop methodology estimate optimum size rainwater tank based roof size roof cover climatic conditions irrigation requirement home irrigation paper presents experimental setup runoff coefficients obtained different types roof materials methodology used calculate optimum storage capacity tank home irrigation designing rainwater tank sizes systems irrigation systems assessed water use efficiency systems comparatively small compared subsurface irrigation based tank sizes obtained study roof runoff water farmers roof sufficient recommended used irrigation source home american society civil engineers
non competitive nmda receptor antagonists known induce psychosis like symptoms rodents administration compounds cause behavioural effects memory impairment hyper locomotion additionally drugs cause distinctive increases striatal local field potential high frequency oscillation band power spectrum sensors provide means measure tissue oxygen like signal brains freely moving rats simultaneously acquiring using electrode carbon electrodes implanted striatum hippocampus male wistar rats rats administered saline recordings made khz using three different potentials measure control conditions nmda receptor caused significant increases striatum hippocampus power spectrum analysis showed significant increases power striatum hippocampus conversely significant decreases delta alpha power along increases theta gamma power hippocampus absent striatum supports findings obtained sensor signal allowing simultaneous acquisition two translational biomarkers neuronal activity elsevier ltd rights reserved
tobacco addiction serious psychosocial health problem pregnant woman influences maternal organism also passes health risks child fetus exposed maternal smoking directly influenced also wide range diseases adult years components tobacco smoke play significant role development number diseases large proportion smoking population among pregnant article summarizes findings regarding impacts production steroid hormones first describing smoking related changes women focusing influence maternal smoking developing assume prenatal development fetus already exposed effect endocrine time fetal begins fetal programming exposure serious pathophysiological effects pregnancy later life example effects delay creation kidney adrenal androgens also evident level steroid metabolites influence individuals psychological state lead later published elsevier ltd
discuss future massively parallel computing fundamental architecture central thesis various versions laws break next two three decades due fundamental limitations imposed laws physics especially quantum mechanics therefore end scaling von based architectures adding cores incremental technology advancements within sight challenges overcome order continue making computation faster cheaper energy efficient reliable one possible answer lies massively parallel models based artificial neural networks paradigms biology neuroscience statistical physics discuss massively parallel computers like based implementing neural networks hardware undertake several thought experiments comparing contrasting hypothetical parallel machines classical multicore large scale distributed computing systems
one major unanswered questions respect commercial use genetic transformation plants stability transgene expression several decades within individual gene expression strongly affected copy number integrated plant genome local dna features close integration sites plants subjected modify transgenic allelic structure without affecting valuable traits cultivar molecular characterization transformation event therefore crucial assessing transgene copy number set apple transgenic clones southern blotting describe two alternative methods first based inverse pcr pcr second quantitative pcr pcr methods produced comparable results exception data regarding high copy number clone pcr based system rapid easily adaptable high throughput systems pcr based method provide information regarding transformation event characteristics sequences flanking transgenic construct
high photo catalytic efficiency degrading organic pollutants realized zno using solar mechanical energy zno arrays vertically aligned stainless steel mesh simple two step wet chemical method mesh supported nanocomposites facilitate efficient light harvesting due large surface area also easily removed treated solution solar ultrasonic irradiation zno rapidly degrade methylene blue aqueous solution investigated process ultrasonic assistance greatly enhance photocatalytic activity performance attributed coupling built electric field piezoelectric field zno built electric field effectively separate electrons holes facilitate carrier transportation component improve visible light utilization piezoelectric field created zno separate electrons holes driving migrate along opposite directions present results demonstrate new water pollution solution green technologies environmental remediation industrial level
differential hybrid charge sensitive designed taking monolithic dual channel junction field effect transistor high speed low noise operational amplifier core parts input stage circuit employs low noise differential dual ensures high input impedance low noise differential dual transistor makes quiescent point first stage differential output stable convenient connecting post stage high speed operational amplifier broadband amplified connecting double differential dual transistors folded cascode bootstrap circuit post stage discrete components traditional integrated operational amplifier simpler reliable simplifies design quiescent point gives full play advantages releasing large open loop gain improves charge voltage conversion gain stability particularly charge voltage conversion gain larger smaller feedback capacitor thus enabling gain better signal noise ratio designed tested reporting charge sensitivity rise time signals signal noise ratio gamma rays noise slope gamma rays measured detector designed room temperature providing energy resolution
limited information regarding neurobiology underlying non suicidal self injury clinically referred youth however salience disturbed interpersonal relationships disrupted self processing associated suggests neural basis social processes key area additional study adolescent participants years divided three groups plus depression diagnosis depression healthy controls scanner participants completed interpersonal self processing task taking direct indirect mothers best friends perspectives regarding self characteristics across perspectives showed higher activation limbic areas anterior posterior cortical structures versus showed greater activity frontal pole occipital cortex youth moreover youth showed heightened responses amygdala hippocampus taking mothers perspective negatively correlated self reports mothers support adolescents emotional distress group youth also yielded greater precuneus posterior cingulate cortex activity indirect self processing perspective findings suggest role disruptions self emotion processing social relationships neurobiology among depressed adolescents elsevier ireland ltd rights reserved
study presents novel reactor based fault current oscillations potential transformer distribution network decreasing amplitude fault current acceptable level first introduced various types studied effects suggested oscillations investigated shown proposed control oscillations also decrease fault current amplitude case short circuit faults occurrence performance simulated using matlab software scaled laboratory prototype implemented tested simulation results validation measured results agreement simulation results clearly show ability controlling fault current
present demonstrate highly stabilized non isolated single mode fiber laser utilizing novel simple inexpensive approach cavity length scheme based intuitive control algorithm programmed embedded microcontroller characterized smooth control signals laser cavity length controlled real time using piezoelectric actuator according pump level inside cavity using control scheme demonstrate ultra stable non isolated fiber laser power variations similar frequency drift hundreds best knowledge first comprehensive report frequency stability properties controlled compare stability laser non controlled investigate impact minimal isolation discuss various parameters affected achievable stability govern laser short long term demonstrated approach highly attractive real life lab applications sufficient thermal mechanical isolation difficult expensive obtain
present study attempt estimate energy exergy potential biogas run dual fuel diesel engine using rice pilot fuel varying compression ratio injection timing objective optimum setting engine based dual fuel characteristics using energy exergy analysis pilot fuel considered study two phase stable water emulsion water content hydrophilic balance value experimentation single cylinder direct injection natural water cooled variable diesel engine converted dual fuel engine experiments conducted different combinations bottom top dead center full load conditions brake mean effective pressure bar parameters analyzed energy exergy potential fuel input shaft work cooling water exhaust gas exergy destruction peak cylinder pressure peak heat release rate brake thermal efficiency exergy efficiency exhaust gas temperature entropy generation rate emission analysis results indicate combination gives better thermodynamic performance particular range operating parameters raw biogas run dual fuel diesel engine using pilot fuel
according group blind inclined shaft machine adopts control system speed control performance poor control circuit complex high noise stability low reliability paper proposes system replace original scheme electric control system paper introduces structure working principle system shows main equipment selection main circuit gives system installation adjustment result shows electric control system characteristics perfect protection control high precision good energy saving effect achieved expected goal
network structures human behaviors considered two important factors virus defense currently however due network security normal users usually take simple activities computer system using computer recovery system clear virus system recovery influences virus spreading taken consideration currently paper new virus propagation model considering system recovery proposed first steady state analysis virus propagation steady time steady states deduced experiment results show models considering system recovery effectively virus propagation furthermore algorithm system recovery scale free network proposed simulation result turns target immunization strategy system recovery works better traditional ones network
background purpose epidemiological data suggests excess risk cardiovascular disease cvd low doses radiation furthermore underlying biological molecular mechanisms radiation induced cvd still unclear damage endothelium critical related cvd study aimed identify effects radiation endothelial cells context atherosclerosis material methods microarrays qpcr used compare response endothelial cells irradiated single ray dose measured various post irradiation repair times day days days mechanistically support endothelial cell response ray exposure identified via microarray analysis dna repair signaling gamma foci quantification cell cycle progression flow cytometric analysis cellular senescence beta assay quantification pro inflammatory status assessed results microarray results indicated persistent changes cell cycle progression inflammation cells underwent arrest dose dependent manner high doses compensated increased proliferation week almost normalized weeks however point irradiated cells showed increased beta activity secretion indicative premature senescence production pro inflammatory cytokines increased early time points conclusions induces pro atherosclerotic processes endothelial cells dose dependent manner findings give incentive research shape dose response curve show even low doses induce premature endothelial senescence later time points furthermore findings time dose dependent response regarding differentially expressed genes cell cycle progression inflammation senescence bring novel insights underlying molecular mechanisms endothelial response ray radiation turn lead development risk reducing strategies prevent induced cvd use cell cycle modulators anti inflammatory drugs radiation
water supply reliability expected affected precipitation amount distribution changes recent future climate change compare historical changes annual mean annual maximum daily precipitation global set station observations global historical network climate models inter impact model project develop study model projections high radiative forcing scenario develop simple rainwater harvesting system model drive observational modeled precipitation study changes mean maximum precipitation along changes reliability model tools assess impact changes precipitation amount distribution reliability precipitation fed water supplies results show faster increase observed maximum precipitation per global warming mean precipitation per increased reliability model driven observed precipitation average per decade models show even faster increase maximum precipitation compared mean precipitation however imply decreases mean reliability average per decade compared observations climate models underestimate increasing trends mean maximum precipitation show opposite direction change reliability model water supply system
paper deals inertial single gas bubble liquid submitted ultrasonic wave aim calculate accurately pressure temperature bubble wall liquid adjacent wall just just collapse two different approaches proposed modeling heat transfer ambient liquid gas simplified approach liquid acting perfect heat sink rigorous approach liquid acting normal heat conducting medium time profiles bubble radius gas temperature interface temperature pressure corresponding models compared important differences observed bubble size exact pressure temperature distributions liquid corresponding second model also presented profiles necessary prediction physical phenomena occurring around bubble possible applications elsevier rights reserved
abnormal expression function myelin related proteins contribute nervous system dysfunction associated neuropsychiatric disorders however underlying mechanism remains unclear found breast carcinoma amplified sequence basic protein abundant brain expressed specifically cells expression level decreased demyelination suggests novel myelin associated protein knockout mice displayed schizophrenia like behavioral abnormalities tendency toward reduced anxiety like behaviors moreover found loss specifically induced expression inflammation related genes brain observations provide novel insight functional link inflammation abnormal behaviors
schizophrenia patients impaired performance abnormal brain activation facial emotion recognition represent marker genetic schizophrenia however remains unclear whether impairment specific recognizing emotion faces instead attributable generalized dysfunction current study aimed distinguish specific generalized neural dysfunction underlying impaired facial emotion recognition schizophrenia examine associations genetic twenty eight schizophrenia patients first degree relatives community controls underwent functional magnetic resonance imaging making judgments either emotion age emotional faces patients performance deficits emotion age discrimination conditions compared relatives controls relatives intact performance patients compared controls across conditions mainly medial prefrontal cortex unlike controls patients demonstrated failure recruit prefrontal cortex region involved social cognition decision making relatives pattern recruitment intermediate patients controls compared controls relatives greater regions associated default mode network patients similar findings age discrimination common patterns performance deficits activation abnormalities emotion age discrimination schizophrenia suggest generalized cognitive impairment notably social cognition decision making contributes impaired facial emotion recognition similar functional activation patterns relatives despite intact performance suggest brain activation represent sensitive marker genetic behaviour default mode network regions relatives represent cognitive compensatory mechanisms help maintain intact performance
equal satisfied least one assigned one assigned max given set boolean variables set find assignment equal satisfied maximized max turns max contains just max approximated respectively little done terms algorithm design approximate max paper propose local search algorithm approximate max show max approximated within polynomial time equal moreover extend algorithm max approximate max contains least
atrial fibrillation mainly triggered foci originating atrial myocardial extensions pulmonary veins aim study evaluate voltage maps surrogate parameter extent subjects ultra high density mapping system sixty four bipolar recorded simultaneously mini catheter placed consecutive patients paroxysmal persistent undergoing isolation system conjunction mini catheter utilized create bipolar electro anatomic reconstruction left mean patients age years paroxysmal persistent mean bipolar voltages follows right superior right inferior left superior left inferior detectable signals total revealed non uniform arrangement area significantly larger superior compared inferior statistical differences terms length found among according type pilot study using ultra high resolution electro anatomical mapping system voltage maps surrogate parameter among patients correspond previous data histopathological studies
genetic variability populations investigated many countries consequently different ecological conditions first studies conducted gather information genetic structure populations sampled temperate climate areas based dna analysis restriction fragment length polymorphism rflp data compatibility groups studies revealed clonal population structure later using dna sequences populations regions north america reported variable temperate regions past years new analyses temperate sub tropical tropical areas conducted using microsatellite markers studies using reported high variability evidence populations evidence also found authors argue populations tropical areas diverse argue reports high variability tropical regions due increase number studies performed markers regions cases due inappropriate interpretations results
rare type congenital heart defects chd genetic mechanism total anomalous pulmonary venous return remains unknown although previous studies revealed potential disease driving regions genes blood samples collected sporadic cases non controls subjected whole exome sequencing detected variations confirmed direct sanger sequencing identified non missense mutations receptor type like delta results offered landscape mutations chinese population firstly valuable mutation based pre post screening genetic diagnosis
background providing correct complete counseling use oral contraceptives central securing autonomy women child bearing age powerful proven tool social change pharmacists many developing countries egypt involved times prescribing pharmaceuticals including oral contraceptives readily available without prescription objectives predict community pharmacists counseling oral contraceptives utilizing theoretical framework guided theory planned behavior methods cross sectional self administered survey completed random sample community pharmacists egypt determine attitudes behaviors regarding counseling multiple regression used predict self reported counseling oral contraceptives function related constructs six factors perceived importance profit pharmacy revenue number hours worked age gender pharmacy practice degree marital status pharmacist results pharmacists invited complete survey participated pharmacists indicated slightly higher proportion women importance taking time daily topics day start taking side effects dose missed pharmacists reported counseling oral contraceptives positively associated perception women pharmacist initiated counseling beta perceived adequacy time available women beta perceived number women asked help selecting without providing prescription past week beta pharmacists reported womens pharmacists initiating counseling associated pharmacists reported percent asked pharmacists advice last women seeking male pharmacists less likely female pharmacists report women pharmacist initiated counseling conclusions appears help predict pharmacists counseling need prepare pharmacists frequently requested assist women selection oral contraceptive interventions facilitate womens requests information valuable increase pharmacists counseling oral contraceptives future qualitative observational studies needed assess complexities counseling oral contraceptives developing countries elsevier inc rights reserved
background attachment theory proven essential mental health including psychopathology development interpersonal relationships validated psychometric instruments measure attachment suffer shortcomings common traditional recent developments multimodal fusion machine learning way new automated objective psychometric instruments adult attachment combine linguistic behavioral analyses assessment construct objective aim study present new exposure based automatic objective adult attachment assessment biometric attachment test participants short standardized set visual music stimuli whereas immediate reactions verbal responses captured several computer sense modalities automatically analyzed scoring classification also aimed empirically validate two assumptions capacity measure attachment security viability using themes rotating stimuli methods total french participants general population assessed using adult attachment questionnaire adult attachment picture system attachment multiple model interview ground truth attachment security exposed three different stimuli sets whereas faces heart rate activity recorded features skin conductance response stress index behavioral features gaze facial expressions linguistic features automatically extracted exploratory analysis conducted using correlation matrices uncover features associated attachment security confirmatory analysis conducted creating single composite effects index testing correlations attachment security stability theory consistent features across three different stimuli sets explored using repeated measures analysis results total theory consistent correlations found exploration total significant correlations example attachment security measured correlated positive facial expressions security father inversely correlated low frequency attachment security partners measured inversely correlated anger facial expression confirmatory analysis showed composite effects index significantly correlated security repeated measures conducted individually theory consistent features revealed features significantly different values among responses three different conclusions able validate two instruments core assumptions capacity measure attachment security viability using themes rotating stimuli future validation dimensions ongoing development scoring classification algorithms discussed
mechanism drug considered complex fully understood reported involve wide spectrum targets involving cholinergic glutamatergic pathways review effect derivatives nmda receptors focus mechanism action biological consequences related alzheimers disease treatment findings indicate effect glutamatergic neurons direct indirect direct effect often reported vitro studies however achieved high concentrations likely occur clinical conditions impact memory behavioral testing ascribed indirect effects caused influencing mediated currents via receptor activation leads inhibition activated potassium channels inhibition prevents membrane polarization leading prolonged activation subsequently long term considering findings conclude derivatives dual modulating activity represent promising approach drug development diseases associated cognitive dysfunction alzheimer disease elsevier inc rights reserved
background purpose cervical artery dissection common cause stroke young people temporal profile stroke risk cervical artery dissection presenting without ischemia remains uncertain methods performed crossover cohort study using administrative claims data emergency department visits acute care hospitalizations using previously validated international classification diseases ninth revision clinical modification codes identified patients cervical artery dissection previous concurrent stroke transient ischemic attack diagnosis compared risk stroke successive week periods weeks dissection versus corresponding week period year later absolute risk increases calculated using test matched data sensitivity analysis limited population patients presenting typical symptoms cervical artery dissection results identified patients dissection without ischemia absolute increase stroke risk confidence interval first weeks dissection compared time period year later absolute risk increase confidence interval weeks longer significant week period findings similar sensitivity analysis identifying patients presented typical symptoms acute dissection conclusions risk stroke cervical artery dissection ischemia time diagnosis seems limited first weeks
setting despite clinical importance idiopathic pulmonary fibrosis ipf epidemiology rarely reported economic burden ipf therefore difficult predict objective analyse health care burden current situation respect medical resource utilisation patients ipf korea methods analysed nationwide data collected korean health insurance review assessment database patients ipf defined code korean classification disease revision results total direct health care costs increased principal factor responsible highest proportion costs proportion total ipf patient population least year average length hospital stay days post hoc analysis hospital admission emergency room visit intensive care unit admission rates showed significant seasonal variations admission rates highest spring lowest autumn conclusions health care costs ipf increasing annually hospital admissions representing major financial burden
group innate lymphoid cells exert critical roles type immune responses epithelial repair mucosal tissues metabolic homeostasis rapidly provide large amounts type signature cytokines thereby driving type immune responses defense however deregulated facilitate tissue fibrosis trigger unwanted type allergies asthma atopic dermatitis therefore need tightly regulated just beginning understand mediators activate inhibit rare important cell population review summarize current knowledge positive negative regulation discuss immunological consequences elsevier ltd rights reserved
primary focus current research goal projection perceivers goal onto interaction partner target extending finding perceivers project goal onto target two studies applied cognitive conceptualization goal pursuit detection explain boundary conditions goal projection conversation experiment demonstrated strength cognitive association perceivers goal social context moderated projection projection greater strongly moderately weakly linked goals experiment established targets goal pursuit efficiency perceivers targets goals influenced projection compared targets efficient pursuit goals projection greater target goal regardless efficiency different goals target inefficient
article describe southern blotting made freely available instructors hope provide clear visualization behind technique instructors solid basis time discuss applications students
forest fire known important natural hazard many countries causes financial damages human losses thus necessary investigate different aspects phenomenon study performance four models linear quadratic discriminant analysis frequency ratio weights evidence investigated model forest fire susceptibility area china purpose firstly forest fire locations map prepared implementing modis satellite images field surveys classified two groups including training validation random algorithm addition forest fire effective factors prepared used slope degree slope aspect altitude topographic index plan curvature land use normalized difference vegetation index annual rainfall distance roads rivers wind effect annual temperature soil texture using training dataset effective factors models applied forest fire susceptibility maps prepared finally area curve auc receiver operating characteristics roc implemented investigating performance models results depicted best performance auc followed auc auc auc respectively results study showed high contribution altitude slope degree temperature hand seen slope aspect soil lowest importance forest fire susceptibility mapping auc results concluded acceptable performance used forest fire susceptibility mapping regional scale
context previous studies reported associated lung fibrosis however role expression treated idiopathic pulmonary fibrosis ipf unknown objective study investigated expression treated ipf compared effects ipf materials methods rat ipf model established injection bleomycin specific pathogen free wistar male rats daily daily times per day used treat rat model administration consecutive days respectively normal rats without ipf used controls days drug treatment lung histopathology assessed expression determined using real time quantitative pcr western blot expression tumour necrosis factor alpha tnf alpha transforming growth factor beta tgf beta platelet derived growth factor determined enzyme linked immunosorbent assay results days drug treatment comparison three drug treated groups model group showed significantly lower significance fibrosis scores lung tissues expression tgf beta tnf alpha expression higher compared group fibrosis score significantly lower protein expression significantly higher group additionally expression negatively correlated fibrosis scores expression tgf beta tnf alpha discussion conclusion inhibit pulmonary fibrosis rat ipf models related enhanced reduced tnf alpha tgf beta
objective purpose evaluate effectiveness progressive muscle strengthening program using swiss ball patients methods sixty patients randomized intervention group control group eight exercises performed patients free weights swiss ball two times per week weeks evaluations performed blinded baseline weeks using following instruments one repetition maximum test minute walk test time test basdai esr crp dosage likert scale results statistical difference groups strength capacity following exercises abdominal reverse fly minute walk test timed test likert scale better results differences observed groups respect functional capacity evaluation using esr dosage conclusions progressive muscle strengthening using swiss ball effective improving muscle strength walking performance patients elsevier
background regarded promising therapeutic agent alzheimers disease however compound relatively rare whereas another abundant nature bacillus ability including previously reported cell factory modified metabolism converts culture medium strain constructed genes related metabolism overexpressing key enzymes using strain initially included medium completely converted within cultivation rich medium containing results initial concentration increased conversion limited therefore overexpression systems main transporter membrane integral nucleotide escherichia coli respectively additionally introduced cell factory conversion efficiency hardly improved systematically determined amount necessary ultimate conversion result conversion reached within cultivation conclusions cell factory improved yield production rate simultaneous overexpression addition conversion medium concentration increased even stationary phase perhaps due nutrients contribute conversion process thus conversion optimized via identification control unknown nutrients
internet addiction become public health issue neglected need investigate issue among school students descriptive correlational study aimed assess prevalence internet addition associated risk factors school students participants aged years selected randomly ten public schools socio data patterns internet usage youngs internet addiction tool symptom checklist anxiety scale anxiety center epidemiological studies depression scale children used findings showed prevalence severe internet addiction highest prevalence internet addiction among students family monthly income fathers completed elementary education mothers completed university higher education academic performance poor friends home place among internet students highest reason internet addiction students experiencing anxiety depression symptoms highest prevalence internet addiction respectively statistically significant relationship age school grade family income academic performance average hours internet daily usage school days anxiety depression internet addiction findings emphasize importance developing implementing interventions preventive measures early diagnosis internet addiction among school students furthermore counseling programs recommended increase awareness families regarding internet addiction responsibilities providing guidance support children elsevier ltd rights reserved
protocol describes perform northern blot analyses detect micrornas precursors single nucleotide resolution crucial analyzing individual length variants evaluating relative quantities unique micrornas cells northern blot analysis consists resolving rnas gel electrophoresis followed transferring membranes detecting hybridization radioactive probes earlier efforts improve method focused mainly altering sensitivity short rna detection enhanced resolution northern blot technique optimizing electrophoresis step also investigated steps procedure goal enhancing resolution rnas herein present several recommendations protocol applicable analyses kinds endogenous exogenous rnas falling within length ranges corresponding microrna pre microrna lengths respectively
article utilizes order explore notions gendered dialogue chinese western theories womens time domestic article proposes works described instances feminine toward drawing film contrast article demonstrates use long take time space ways everyday captured calls feminine details finally present article argues fear pregnancy reconfiguration linear time reversal gender roles style presents potential new kind union new kind upon gendered forms
medically assisted significantly contributes increase twin pregnancies one major factors contributing twin births use fertility treatments twin pregnancy without risk fetal organ development health outcome new children adults multiple pregnancies associated increased risk developmental complications perinatal mortality premature births low birth weight oxidative stress involved pregnancy disorders abortion intrauterine growth retardation prenatal mortality link oxidative stress prenatal development poorly perceived medical community major problem human reproductive medicine health outcomes sex based considerations analyses also often neglected biomedical research addition fetal sexual antioxidant pathways following intrauterine exposure environmental pollutants explored important area research sexually antioxidant adaptive responses early life exposure induced oxidative stress long term effects offspring health outcome increase risk non diseases men women concept useful since open avenue develop antioxidant therapeutic strategies developmental disorders complications related multiple pregnancies association acute chronic environmental exposure article reviews status research supporting data possible pathogenic mechanisms future perspectives proposed area birth defects research part wiley periodicals inc
objective complete traumatic young athletes rare optimal treatment unclear purpose article present experience efficacy surgical repair bony dislocation discuss complex postoperative rehabilitation methods three young athletes sustained complete bony dislocation different sport activities long jump soccer age time injury ranged years underwent surgical repair muscle complex origin time injury repair varied weeks patients underwent specific postoperative rehabilitation program follow ranged months results athletes improved surgery good subjective objective functional results one patient needed operative revision day primary repair excessive muscle contractions wake general anesthesia finally returned sport level conclusions young athletes traumatic dislocation benefit operative repair good results achieved cases basis functional recovery patient satisfaction chronic complaints avoided also return sport possible surgery spinal anesthesia recommended
purpose study aims validate score predicting risk complications pediatric patients chemotherapy related neutropenia evaluate performance previously published models risk stratification patients methods children diagnosed cancer presenting evaluated prospective single center study score predicting risk complications previously derived unit validated prospective cohort performance six predictive models published geographically distinct settings assessed cohort results complications observed episodes months risk score based two points time last chemotherapy five points absolute neutrophil count per two points used patients low risk score assessed using following parameters overall performance calibration calibration slope test discrimination statistic overall sensitivity negative predictive value clinical net benefit six previously published rules demonstrated inferior performance cohort conclusion indigenous decision rule using five simple predefined variables successful identifying children risk complications prediction models derived developed nations appropriate low middle income settings need validated use
article presents recent efforts improving efficiency scalability mixed cell computation step context method solving systems polynomial equations important problem applied mathematics method important numerical method task method necessary preprocessing step known mixed cell computation problem main bottleneck parallel efficiency scalability article presents recent remarkable improvements parallel scalability algorithm applicable wide range hardware architectures including multi core systems systems computer clusters gpus devices elsevier ltd rights reserved
background antibody mediated rejection contributes heart allograft loss however important knowledge gap remains terms pathophysiology detection immune activity injury degree stage improved gene expression profiling methods prospectively monitored heart transplant recipients referred french transplant centers january january compared patients matched control group patients without characterized patients using histopathology international society heart lung transplantation grades immunostaining circulating anti hla donor specific antibodies time biopsy together systematic gene expression assessments allograft tissue using microarrays effector cells evaluated vitro human cell cultures studied validation cohort heart recipients transplanted canada including cases controls results total heart transplant biopsies assessed showed distinct pattern injury characterized endothelial activation inflammation monocytes macrophages natural killer cells also observed selective changes endothelial angiogenesis cell transcripts including signaling interferon gamma inducible genes selective gene sets accurately discriminated patients without included transcripts area curve endothelial activation transcripts area curve macrophage transcripts area curve interferon transcripts area curve comparisons gene sets showed increased expression increasing pathological international society heart lung transplantation grade association donor specific antibody levels unsupervised principal components analysis demonstrated high proportion molecularly inactive significant molecular overlap full cases endothelial activation transcripts interferon transcripts showed association chronic allograft molecular architecture selective transcripts together gene set discrimination capacity identified discovery set reproduced validation cohort conclusions tissue based measurements specific pathogenesis based transcripts reflecting burden endothelial activation macrophage burden interferon effects accurately classify correlate degree injury disease activity study illustrates clinical potential tissue based analysis gene transcripts refine diagnosis heart transplant rejection
three experiments reported explore based spontaneous evaluative impressions stimulus persons experiments used modified versions savings paradigm confirm occurrence indicating equivalent whether participants instructed form trait impressions evaluative impressions neither experiments also show occur independently explicit recall trait implications stimuli experiment provides single dissociation test distinguish spontaneous trait inferences stis showing disrupting cognitive processing trait based prediction task presumably reflects stis based social approach task presumably reflects implications findings potential independence spontaneous trait evaluative inferences limitations important steps future study discussed
reconstruction point spread function critical process weak measurement develop real data based oriented pipeline compare performances various reconstruction schemes making use large amount data performances three classes schemes polynomial evaluated find polynomial optimal orders domains perform best quantify effect residual reconstruction error shear recovery terms additive biases spatial correlations using shear measurement method find impact reconstruction uncertainty shear shear correlation significantly reduced cross correlating shear estimators different exposures takes greater similar per square exposure reach best performance interpolation requirement satisfied data
meet person article presents synthesis two interviews senior center education management school business university researcher number areas management scholarship group decision making nominal group technique managing innovation change career extending years experienced shift late career toward study executive leaders interviews shift providing example successful career transition personal insight new areas research career example engaged scholarship academic researcher development academic product
background blood feed classes vertebrates including humans also known australian capable causing myriad clinical issues humans animals including transmission infectious agents toxin mediated allergic inflammatory reactions mammalian meat allergies humans australian endemic australia two exported cases reported literature case report report third exported case caused imported patient singapore also discuss clinical course patient salient points management proper removal species emergency physician aware increasing air travel emergency physicians need aware identify imported cases institute proper management advice patient also describe identification features proper method removal species elsevier inc rights reserved
improve identification capability algorithm time varying sparse system propose block parallel algorithm paper proposed algorithm first introduce norm constraint promote application sparse system second use shrinkage method improve track ability third adopt widely linear processing take advantage non circular properties communication signals last reduce high computational complexity make easy implemented utilize coordinate descent iterations parallel processing deal tap weight update proposed algorithm verify convergence condition proposed algorithm also analyze steady state behavior several simulation done results show proposed algorithm achieve faster convergence speed lower steady state similar type algorithm apply proposed algorithm decision feedback error rate decreases obviously
purpose cells specialized antigen presenting cells link innate adaptive immunity recognition presentation antigen cells although importance dendritic cells demonstrated many animal models contribution human immunity remains relatively unexplored central role infection autoimmunity malignancy dendritic cell deficiency dysfunction expected clinical dendritic cell deficiency disorders related binding protein interferon regulatory factor mutations highlighted importance dendritic cells monocytes primary immunodeficiency diseases begun light roles host defense immune regulation vivo contribution dendritic cell monocyte dysfunction pathogenesis primary immunodeficiency disease phenotypes becoming increasingly apparent however dendritic cell analysis yet routine part primary immunodeficiency disease uptake dendritic cell monocyte screening clinical practice facilitate discovery novel dendritic cell monocyte disorders advancing understanding human dendritic cell biology health disease
paper small remote area located nigeria considered model tested managing scheme providing electricity water strategy groundwater water tank later used supplying required irrigation drinking water pump turbine used hybrid system supplying electricity water storing water water tank also photovoltaic plant package batteries addition diesel ice internal combustion engine used optimized along best size devices managing system purpose obtaining maximum economical operating strategy paper two cases considered assess effectiveness system study firstly mentioned devices used show internal combustion engine system components due low cost fuel second case renewable resources exploited optimized order make renewable system least possible cost variables makes problem complicated requires solved algorithm accuracy therefore modified gravitational search algorithm adapted mutation used find best cost management strategy first case although cost diesel oil low using diesel oil consumption reduced second case order make renewable system size enlarged approximately times comparison first case hybrid storing structure capable deliver water irrigation domestic requirements electricity needed rural community elsevier ltd rights reserved
adsorption behavior unstable proteins bovine serum albumin alpha studied hydrophobic interaction chromatography medium mass conditions different salt concentrations mobile phase mechanistic model formulated used describe kinetics thermodynamics protein interactions adsorbent surface model assumed two site binding adsorption reversible protein allowed predicting inhibition protein high column loadings simplified procedure determination model parameters developed based inverse method model successfully used reproduce pattern chromatographic course breakthrough curves model formulation supported nano differential scanning measurements exploited determine protein stability liquid phases different column loadings salt concentrations elsevier rights reserved
throughout united states rise public discourse transgender people transgender issues much attention stems passed proposed anti lesbian gay bisexual transgender questioning legislation including require transgender people use public facilities corresponding sex designated birth recent discussion legislation impacting school aged children adolescents mean school nurses care advocate transgender students article aim school nurses join discussion advocate inclusive school policies deliver gender care transgender students explain transgender identities transgender related stigma prejudice discrimination health concerns gender approaches caring transgender youth implications school nurses school nurses play key role creating space transgender students
heat stress dry period affects gland development metabolism immunity transition period however effect late gestation heat stress performance immune status unknown objective evaluate effect heat stress final similar gestation growth immune function treatment born exposed cooling heat stress dry period used measurements growth immune status birth managed identical conditions fed respective dams within birth age body weight obtained weaning monthly height measured monthly plasma total protein assessed birth age total serum igg evaluated age apparent efficiency absorption calculated peripheral blood mononuclear cells isolated age proliferation rate measured incorporation vitro blood cortisol concentration measured dry period period gestation length shorter compared greater birth compared decreased weaning similar compared less total plasma protein total serum igg apparent efficiency absorption tended decreased additionally greater peripheral blood mononuclear cell proliferation relative fold compared late gestation affect blood cortisol concentration dry period period tended increased circulating cortisol birth conclude heat stress dam dry period fetal growth immune function offspring birth weaning
hydrogen produced vascular tissue anti oxidant properties study investigates whether chronic treatment using fast donor elicit effect diabetes diabetes induced male mice streptozotocin daily confirmed elevated blood glucose levels diabetic mice treated mol day collected functional biochemical analyses diabetic group endothelium dependent basal nitric oxide center dot bioactivity significantly reduced maximal center dot donor sodium impaired aorta compared control mice vascular superoxide generation via nicotine adenine phosphate nadph oxidase elevated aorta diabetic mice associated increased expression treatment diabetic mice restored endothelial function exogenous center dot efficacy back control levels treatment also reduced diabetes induced increase nadph oxidase activity affect protein expression data show chronic treatment diabetes induced vascular dysfunction restoring center dot efficacy reducing superoxide production mouse aorta
previous studies biological genetic evidence indicate gene influence schizophrenia performed genetic association study han chinese cohorts five single nucleotide polymorphisms within promoter region one intron positively associated another study selected genotyping patients schizophrenia mentally healthy controls genotype allele frequencies assessed gender stratification interestingly showed strong association schizophrenia allele frequent cases controls vitro promoter assay showed transcription activity allele promoter higher allele promoter allele contributed risk schizophrenia males females found gender specific association schizophrenia allele frequent male cases compared male controls data suggest promoter polymorphism possibly contributed risk schizophrenia transcription activity han chinese individuals
free convection inclined plate thermally stratified high porous medium presence magnetic field studied dimensionless momentum temperature equations solved numerically explicit finite difference technique help computer programming language visual obtained results studies discussed different values known parameters different time steps also stability conditions convergence criteria explicit finite difference scheme analyzed finding restriction values various parameters get accuracy effects various governing parameters fluid velocity temperature local average shear stress number investigated presented graphically authors published elsevier ltd
evaluating performance distributed systems real experimentation resource consuming essence difficult reproduce conversely analytical modeling simulation facilitate investigation level needs evaluated avoid paper combine production experiments realistic simulation performance modeling optimization application workflows deployed european grid infrastructure one largest distributed systems world use validated simulator evaluate analytical model application study influence calibrate parameters application workflow particular period experimental results show model fits simulated relative error simulation allows validate analytical models exhaustive manner possible production experiments results also show provided simulator correctly validated simulation safely used exhaustive parameter studies allowing quick fine tuning sensitive application parameters elsevier rights reserved
gene expression regulated several levels plants one recently discovered regulatory layers involve short rnas short rnas produced several pathways target either mrnas genomic dna different classes short rnas slightly different sizes detection accumulation important step validating studying non coding short rnas northern blotting routinely used detect short rnas gives information amount size analysed short rnas choice right rna extraction protocol crucial short rnas studied several routinely used commercial rna extraction kits yield short rnas chapter describes optimised rna extraction methods give good yields short rnas separation transfer protocols study accumulation short rnas
big data technology developed management data large volumes different varieties data processed optimal velocity data dealt structured unstructured relational databases typical examples structured data methods techniques researches relational database management known paper describe formalism structured data considered directly generalized model relational databases higher structured data generalization defined set lower structured data consequently study proves many concepts results relational database management transferred structured data accordingly generalization sub data components structured data functional dependencies structured data keys data structured data defined studied concepts defined structured data applied relational databases special case paper operations structured data structured data defined studied appear quite suitable relational databases fact introduced offers effective methods structural algebraic researches structured data
many recent studies reported microrna mirna biogenesis function related molecular mechanisms various clinical diseases several methods including northern blotting dna chip analyses capable assessing mirna production patterns cells however development repetitive monitoring mirna production profile noninvasive manner application mirnas human medicine describe noninvasive system monitoring mirna biogenesis stage primary transcripts mature mirna regulation review optical methods developed image mirna production step mirna processing pathway living subjects propose optical mirna imaging strategy based molecular imaging used mirna imaging detector monitor various mirnas using different simultaneously high throughput screening provide potential application diagnosis therapeutics multiple diseases
objectives although widely used chronic pain remains considerable controversy therapeutic value neck pain aimed determine effect size applied lower back points assess impact neck pain design cohort analysis treatment outcomes pre stimulation involving patients history nonspecific chronic neck pain subjects settings patients enrolled group therapists attending educational asked report pain levels pre post hours single application interventions measurements direct current point stimulation applied standardized lower back protocol points used evaluations baseline visual analog scale vas pain scale assessment using vas repeated twice therapy immediately follow period patients received single session results analyzed using paired tests results outcomes pain intensity showed initial statistically significant reduction points mean neck pain levels standard protocol treatment compared initial pain levels statistically significant reduction mean neck pain levels compared pain levels immediately standard protocol treatment points total average pain relief conclusions positive results study applications patients impacted chronic neck pain
taken individually ground source heat gsh systems rainwater harvesting new combination energy water blend relatively recent becomes water harvesting tank installing gsh collectors base potential heat buildings provide flood resilience improve water quality review literature found coefficients performance suggest systems considered viable reaching value required renewable energy small scale laboratory based test combined system able reduce pollutants biological oxygen demand ammonia nitrogen rare occurrences potentially pathogenic bacteria low survival rates escherichia coli whilst test provide valuable information field monitoring building scale way validate technology thus paper presents previously results monitoring combined system building scale found clear potential use clean renewable sustainable source heat time providing flood resilience water quality improvements domestic setting however also found seasonal changes building use affected levels comfort achievable lessons construction strategies optimise design including depth heat collectors optimal surface area available water elsevier ltd rights reserved
adsorption water operating pressure low kpa cooling power generation affected height water column resolve issue experimentally investigate performance function water height results show optimum water height equal tube diameter leading achieve highest cooling power condition internal external thermal resistances inside outside tubes account overall thermal resistance reduce internal thermal resistance type turbulent flow generators incorporated tubes cooling power shows increase tape type used cost increase internal pressure drop times respectively tape type improve average specific cooling power adsorption respectively reduce external thermal resistance outside surface tubes coated porous copper coated increases overall heat transfer coefficient times improves specific cooling power adsorption compared tubes elsevier ltd rights reserved
impairments executive functioning give rise reduced control behavior therefore risk factor violence criminal behavior however contribution specific underlying processes remains unclear crucial element executive functioning essential cognitive control goal directed behavior visual attention elucidate importance attentional functioning general population employed attentional capture task measure visual attention expected offenders impaired visual attention revealed increased attentional capture compared healthy controls comparing performance offenders healthy community controls found hypothesis partly confirmed offenders accurate overall accurate absence information suggesting superior attention presence information offenders significantly less accurate compared information present together findings indicate violent offenders superior attention yet worse control attention violent offenders adjusting unexpected irrelevant stimuli relate failures self regulation inhibitory control
point view power engineering successful commercial market electric vehicles demands completely new concept integration contemporary electrical network electric vehicles limited range charged short periods means grid problems peaks daily load profile paper outlined one promising network help systems agent evaluates data vehicles small area area relative independently main problem create algorithm optimal cooperation communication agents example cooperation shown firstly simple linear programming problem secondly complex using game theory mathematical basis systems system connected smart grid possibilities altering load profile shown last chapter explores necessity shift grid artificial intelligence modal logic presented possible solution
latest anti tumor necrosis factor tnf gained marketing license thanks pursuit induction maintenance trials approved treatment ulcerative colitis anti tnf drugs available infliximab adalimumab two drugs validated algorithms concerning prescription therapeutic drug monitoring little known available data exposure response relationship pursuit trials recently published data reveal factors impact pharmacokinetic parameters dosage body weight concomitant drugs presence anti drug antibodies sex age addition trough level steady state appears correlated patients improvement make indicator predict clinical response however consensus possible therapeutic level cutoff associated clinical response remission outcome measure endoscopic healing lack threshold value validation different assay techniques makes difficult use clinical practice anti tnf agents associated development prevalence effects still described objective review describe current data understanding including serum concentrations patients better understanding parameters lead improved patient care
real time image filtering technique proposed result faster implementation image enhancement one major associated filtering techniques expensive nature hardware implementations circumvent modified anisotropic gaussian filter efficiently adopted hardware filter two orthogonal oriented line gaussian architecture developed dynamically controlling orientation line gaussian filter improve performance filter input image local image normalization proposed structure middle range reconfigurable fpga parallel compute intensive real time demands achieved manage efficiently speed image processing time improve resource utilization fpga test results show improved speed hardware architecture maintaining reasonable enhancement benchmarks
objectives angioedema potentially life threatening occurrence encountered critical care providers mechanistic understanding angioedema syndromes improved recent years novel medications available improve outcomes syndromes clinically focused review describe underlying genetics pathophysiology classification treatment angioedema syndromes emphasis novel pharmacologic agents recently become available acute treatment data sources medline search conducted mesh terms angioedema acquired angioedema hereditary angioedema type iii angiotensin converting enzyme inhibitor induced angioedema study selection selected publications describing angioedema clinical trials diagnosis management genetics retrieved reviews guidelines clinical trials case series also reviewed identify relevant publications data extraction data relevant publications reviewed summarized information synthesized data synthesis data obtained used describe current state diagnosis management various angioedema syndromes conclusions angioedema life threatening syndrome multiple subtypes distinct pathophysiology present evidence based approach diagnosis suggested management various subtypes angioedema securing airway remains important intervention followed administration established novel pharmacologic interventions based disease pathology care med
proportional integral derivative pid controller design based gaussian process model proposed study model defined mean covariance function provides predictive variance addition predicted mean model highlights areas prediction quality poor due lack data indicating higher variance around predicted mean variance information taken account pid controller design used selection data improve model successive stage results trade safety performance due controller avoiding region large variance cost tracking set point ensure process safety proposed direct method evaluates pid controller design gradient calculation order reduce computation characteristic instantaneous linearized model extracted linearized framework pid controller design two case studies continuous batch processes carried illustrate applicability proposed method elsevier ltd rights reserved
background cell necrosis oxidative damage involved cirrhosis development condition insulin like growth factor igf levels diminished study evaluates whether exogenous administration low doses igf induce acute carbon induced liver damage compared healthy controls igf additionally impact igf deficiency damaged liver investigated mice partial deficit hormone methods three groups week old healthy male mice igf included protocol untreated controls controls received treated subcutaneously igf body weight day days parallel three igf deficient mice groups studied untreated igf microarray real time quantitative polymerase chain reaction qpcr analyses serum levels liver histology malondialdehyde mda levels assessed end treatment groups data represent mean sem results altered gene coding expression pattern proteins extracellular matrix fibrosis cellular protection found compared healthy controls igf therapy normalized series including healthy mice liver histology showed mice less oxidative damage fibrosis lymphocytic cellular changes compared moreover correlation mda levels histological damage score pearsons igf deficient mice series similar findings identified much vulnerable hepatic conclusions treatment improved biochemistry histology genetic expression pro regenerative factors series healthy igf deficient mice acute liver damage suggesting low doses igf acute liver damage feasible therapeutic option
classic research initiated response heavy reliance childrens evidence certain types criminal cases showed incidence false memories declines steadily childhood young adulthood developmental decline pattern became much expert treated science court science large number studies recently appeared developmental opposite pattern false memories events preserve experience increase dramatically early childhood young adulthood developmental challenge forensic principle childrens evidence inherently infected false memories adults evidence
causative agent disease major public health problem latin america parasite complex population structure comprised six seven major evolutionary lineages discrete typing units apparently resulted ancient hybridization events existence significant biological differences lineages strain characterization methods essential study different vectors hosts however available methods costly limited resolution sensitivity study new genotyping strategy real time pcr identify six clinical blood samples developed evaluated two nuclear rdna two mitochondrial genes selected develop original primers method evaluated eight genomic dna populations belonging six one genomic dna blood samples individuals chronic disease assays analytical sensitivity dna per reaction tube depending analyzed selectivity trials genomic dna identified excluding non targets every test method able characterize chronically infected clinical samples high detection followed proposed original genotyping methodology established high sensitivity single real time pcr assay novel protocol reduces contamination enables detection independently future quantification clinical blood samples elsevier rights reserved
malformations underlie many diverse neurological signs symptoms headaches common presentation significant impact quality life objectivethe authors investigated gamma outcomes patients associated headaches methodsthis retrospective study analyzed patients underwent patients headache symptoms led diagnosis developed post hemorrhage information regarding headache characteristics obtained patients medical records follow using clinical interview median imaging follow months clinical follow months median treatment volume median marginal dose resultsthe rate years years patients reported overall headache severity decreased headache frequency reduced headache reduction reported patients year years median time improvement months headache medication usage decreased patients permanent adverse radiation effects occurred patients complete annual risk hemorrhage per year recall bias related retrospective analysis impact outcomes headache symptoms associated potentially decreased eliminated subset patients treated gamma
spp hybrids remain among mostly widely species world principally diverse genome site adaptability relatively fast growth rates numerous pure species yet hybrid clones globally deployed industry seeks meet growing demands wood products result various propagation approaches explored seeds propagation trough vitro method view remaining cost effective yet efficient sustainable propagation preferred valuable offers commercial range species hybrids commercial use however resulted array propagation protocols researchers seek optimise growth conditions enhance quality yields rooted vitro exogenous supply plant growth regulators central objectives protocols present review traces recent developments propagation presents selection published protocols variety species explants supply advancements plant physiology molecular biology biochemistry picture physiological growth requirements steadily develops leading researchers accurately manipulate improve propagation furthermore recent completion genome sequence drive advancements genomics metabolomics proteomics collectively developments present future opportunities accurately augment significantly enhance sustainable growth yields valuable traits conservation
context authors reported nationally representative data number sport injuries resulting emergency department existing studies provided years data longitudinal nature objective use novel algorithmic approach determine due resulting substantially larger longitudinal dataset design descriptive epidemiology study setting hospital patients participants national hospital ambulatory medical care survey stratified random sample survey hospital eds combined years patient visits determined main outcome measure custom algorithm classified visits based international classification diseases ninth revision clinical modification code pattern recognition narrative text sport visits assessed age categorized according broad injury classifications additional quantification performed visits lower extremity knee specific injuries sample weights applied provide national annual estimates results annually visits resulted largest classification injury sprains strains males substantially related visits females versus patients years old lower extremity knee specific injury visits annually injury types males higher rate however females greater odds lower extremity knee specific injury respectively conclusions burden health system visits substantial males presented higher rate injury though females higher proportion lower extremity knee specific injury longitudinal analysis population level data provides information target research specific subpopulations mitigate injury
past years considerable progress made understanding mechanistic enzymology radical sam enzymes now clear enzymes appear involved remarkably wide range chemically challenging reactions review article highlights mechanistic structural aspects sub class radical sam enzymes mechanism insertion now observed performed three different enzymes exciting problem article part special issue entitled radical sam enzymes radical enzymology elsevier rights reserved
two competing theories address influence testosterone cerebral one proposing exposure high testosterone concentrations related atypical hypothesis high testosterone concentrations typical hypothesis current study examined relationship cord testosterone concentrations cerebral language spatial memory adulthood male participants high nmol low nmol cord testosterone levels invited take part study group cerebral measured using functional transcranial doppler ultrasonography participants completed word generation visual short term memory tasks typical left language common high testosterone group low testosterone group chi spatial memory unrelated cord testosterone level findings indicate testosterone exposure related language direction supports hypothesis elsevier rights reserved
coverage connectivity two important problems wireless sensor network paper focuses wireless sensor network communication radius high density sensor nodes deployed randomly two times smaller sensing radius put forward distributed coverage multi connected node deployment algorithm based grid simulation results show algorithm paper guaranteeing wireless sensor network coverage connectivity reduce number active state nodes effectively prolong wireless sensor network lifetime theoretical analysis results show article nodes deployment algorithm achieves multi connected
educating future engineers gain high computational thinking essential career prospects educators acquiring good understanding various learning motivation factors tools inter relationships significant step forward achieving goal article describe exploratory data analytic investigation influences various learning motivation factors one another learning group science engineering students taking computer programming courses based algorithmic results highlight concrete ideas direct impact improving existing learning system describe graphical visualization algorithmic results guide set priority focusing learning motivation factors first factors next achieving given education goal among new insights easily confirmatory based analyses
drilling using frequently used secondary machining fiber reinforced composite important concern drilling design drilling parameters associated thrust distribution drilling induced presented core center found advantageous core reference practice experiences response surface methodology practical economical useful tool modeling analysis experimental results using polynomials local approximations true input output relationship due radial basis function networks fast learning speed simple structure local tuning global generalization power researchers field manufacturing engineering using nonlinear manufacturing studies present paper compares two techniques using various drilling parameters diameter ratio feed rate spindle speed predict thrust force core center drilling composite materials obtained results indicated practical effective way evaluation drilling induced thrust force
background nutrition life sustaining therapy appropriate clinical settings hospital setting patients develop hyperglycemia subsequently require long term insulin receiving whether similar hyperglycemia seen outpatient setting unclear methods studied patients enrolled clinic home nutrition program january december patients excluded diabetes mellitus type previously received taken corticosteroids risk syndrome results enrolled patients met inclusion criteria patients requiring addition insulin mean age insulin requiring group higher non insulin requiring group nir years years men group men nir group mean blood glucose baseline starting infusion patients nir patients stepwise multivariate analysis assessing risk developing hyperglycemia age conclusions hyperglycemia common finding use hospital ambulatory setting patients without previous diagnosis age significant predictor requirement insulin present study hyperglycemia managed appropriately insulin therapy long term complications minimized
proportional integral derivative pid controller frequently used controller design industrial applications favorable response simplicity adjustment however pid manual tuning traditionally based engineering experience adjusting nonlinear unknown systems extremely difficult promoting intelligent controller design theory applied control various systems paper proposes nonlinear control design method involves determining optimal solution obtaining transfer function unknown system using sequential quadratic programming addition paper presents case study induction motor speed control demonstrate effectiveness proposed method based matlab simulation results prove design proposed intelligent pid controller robust traditional controller designs
engineering courses benefit using remote laboratories support activities online learning remote control system effective tool used practical classes enhance students experimental skills online experimentation also important support engineering teaching used improve students learning process instance electrical engineering courses particularly topics related systems automatic control paper describes online experiment demonstration remote lab system aiming identifying model given nonlinear system design apply controllers based different methodologies experimental setup used interact remote lab web based platform students visualize collect data real time available remote system ifac control elsevier ltd rights reserved
evolution design test results novel permanent magnet generator use direct drive wind turbines presented generator topology based steel core modules make rotor air stator winding topology allows reduction structural mass large diameter generators lead lightweight generators copyright john wiley sons ltd
background various insect species added genomic databases years thus researchers easily obtain online genomic information insects however many annotated genes included databases prevent correct interpretation subsequent functional analyses address problem used combination dry wet bench processes select functional genes public databases results important enzyme organisms used combination dry wet bench processes identify functional first detected five annotated public databases using hidden markov model search cdna cloning northern blotting rna seq analysis revealed three functional contained conserved key amino acid residue metal binding substrate binding species however showed change key amino acid phylogenetic analysis showed distinct distributed clusters expressed tissues used study contrast mainly expressed testis expression ovary ganglion weakly expressed testis quantitative pcr showed mrna expression correlated testis development thus related specific conclusions identified characterized three functional public databases combination dry wet bench processes addition determined species specific functions strategy helpful detection minor genes functional genes non model organisms public databases
survey genetic improvement general purpose computing graphics several experiments demonstrate four themes experiments program show genetic programming automatically port sequential code parallel code experiments program show upgrade legacy parallel code new hardware software experiments show make substantial improvements current parallel cuda applications finally experiments program show semi automated approaches enormous speed ups sometimes growing grafting new code genetic programming combination human input
background objective examined seasonality winter seasonal affective disorder sad old order county unique population use network electric light homes methods estimated sad using seasonal pattern assessment questionnaire adults compared frequencies sad total sad presence either sad sad men women young old awareness ever never heard sad heritability global seasonality score estimated using maximum likelihood method including household effect capture shared environmental effects results mean prevalence sad total sad heritability adjusting age gender household effects limitations limitations include likely rates sad possible selection bias recall bias limited generalizability study conclusions sad prevalence lower observed earlier based studies predominantly caucasian populations low heritability sad suggests dominant environmental effects effects awareness age gender sad risk similar previous studies identifying factors resilience sad face seasonal changes suggest novel preventative therapeutic approaches reduce impact sad general population elsevier rights reserved
study economic performances consecutive multi span suspension bridges carried part study material amount structural cost estimation formulas bridges derived based structural ultimate carrying capacity bridge cost includes part part three types bridge foundations concrete floating foundations considered formulas used parametric study bridge cost order define economical layout different conditions part two study
objective work minimize testing cost analog circuits complete specification tests available use integer linear program eliminate many tests possible without exceeding required defect level method leverages correlation among specifications thereby avoiding tests specifications sufficiently covered tests specifications first monte carlo simulation determines probabilities test covering specifications originally intended probabilities given defect level define model eliminating unnecessary tests hypothetical example illustration ten specifications demonstrates depending defect level requirement half tests eliminated monte carlo simulation using spice probabilistic characterization tests versus specifications followed optimization two commercially available integrated circuits operational amplifier radio frequency power controller presented evidence effectiveness technique
gut microbiome consists bacteria play important role human metabolism animal human studies implicated distortion normal microbial balance obesity metabolic syndrome bacteria causing weight gain thought induce expression genes related lipid carbohydrate metabolism thereby leading greater energy harvest diet large body evidence demonstrating alteration proportion leads development obesity recently challenged likely influence gut microbiome obesity much complex simply imbalance proportion bacteria modulation gut microbiome diet pre probiotics antibiotics surgery fecal transplantation potential impact obesity epidemic
growing evidence supporting use lay health workers address treatment gap common mental disorders task shifting study looks experience delivering problem solving therapy intervention people living hiv primary health care setting semi structured interviews received carried using thematic content analysis year period developed indigenous concepts opening mind strengthening strengthening respectively using terms locally conceived knowledge sharing amongst made acceptable deliver part daily work indigenous terms conceived developed describe components processes contribute acceptability continued use primary care facilities
change serum metabolic response fasting state state provides novel insights impact single meal human metabolism therefore study explored changes serum metabolite profile single meal nineteen healthy postmenopausal women normal glucose tolerance participated study received meal consisting refined wheat carbohydrates protein fat dietary fibre orange drink blood samples collected fasting five time points metabolic profile measured nuclear magnetic resonance targeted liquid chromatography mass spectrometry changes time assessed multivariate models anova baseline control analyses demonstrated alterations amino acids breakdown products products bodies single meal specifically citrate displayed overall declining pattern leucine methionine increased initially declined thereafter sharp decline bodies increase products suggest switch energy source beta oxidation glycolysis moreover individuals relatively high insulin responses generated higher leucine responses compared participants lower insulin responses study demonstrated complex changes metabolism meal indicated extent responses different individuals high low insulin response
inadequate resistance pavement surface substantial reason traffic accidents close relationship sliding resistance characteristics texture morphology demanding high precision comprehensive acquisition morphology traditional three light sources stereo method improved study first six light sources adopted enhance illumination eliminate incomplete information retrieval pavement surface image second low rank approximation proposed image processing stage significantly reduce interference noise highlights shadow resulting higher precision reconstructed pavement surface compared existing stereo method using three light sources third unlike control point based weighting algorithm control point based surface interpolation algorithm established optimizes precision reconstructed surface combining effect global integration elevation positions relative points testing indoor conditions surface interpolation stereo method control points using low rank approximation effectively measure morphology last low rank approximation global integration six light sources used requirement surface interpolation stereo method control points statistical analysis indicates low rank approximation global integration six light sources effective method three dimensional morphology american society civil engineers
paper present new high accuracy multiplier circuits focused implementation original techniques improving linearity proposed structures new approach designing high precision using multifunctional cores presents important advantage allowing facile reconfiguration designed circuits multiplier core able implement multitude additional circuit functions square simulating positive negative equivalent resistance multiplier structures designed low voltage low power operation supply voltage implementing cmos technology current consumption smaller proposed multiplier
introduction inappropriate use oral anticoagulants however frequent real world practice patients atrial fibrillation study designed evaluate prescription patterns appropriateness patients real world clinical settings methods performed prospective observational study total patients screened prescription appropriateness prescribing evaluated using criteria medication appropriateness index indication choice dosage modalities administration drug drug interactions drug disease interactions duplication duration criterion rate whether medication appropriate inappropriate limited clinical importance inappropriate results patients warfarin group group therapy group showed group group group patients least inappropriate criterion moreover according choice criterion group group group rated inappropriate dosage appropriate group group group conclusion inappropriate drug use frequent among patients warfarin also although apparent improvement much effort needed appropriate use
insect works first line defence protect insects pathogenic infections water evaporation however old order enter next developmental stage fluids produced secreted area among old new previous study protein single domain von factor type identified fluids demonstrated regulate study show larvae primarily epidermal cells wing head stage released fluids produced epidermal cells fungal infection shown decrease amount indicates target protein fungi thus mainly involved maintaining integrity structure serves protect insects physical damage pathogenic infection
traditional vaccination approaches live attenuated microorganisms among effective means prevent spread infectious diseases approaches nevertheless failed yield successful vaccines many important pathogens overcome problem methods developed identify microbial components protective immune responses elicited subunit antigens identified approaches enable production defined vaccines improved safety profiles however generally poorly immunogenic administration potent since safe effective currently used vaccines approved human use available displaying poor potency inability stimulate types immune responses required vaccines specific diseases cytotoxic lymphocytes treat cancers development new vaccines aided availability characterized platforms new improving capacity select different applications one approach involves addition microbial components pathogen associated molecular patterns stimulate strong immune responses subunit vaccine formulations conjugation subunit antigens provides means greatly increase vaccine potency targeting antigen antigen presenting cell thus methods enable efficient inexpensive production antigen adjuvant represent exciting mean improve immunity towards subunit antigens herein review four protein based bacterial extra domain heat shock proteins genetically fused antigens enable recombinant production antigen adjuvant fusion proteins focus mechanisms action structural sequence requirements activity sequence modifications enhance activity simplify production adverse effects examples vaccines preclinical human clinical trials elsevier inc rights reserved
growing global awareness climate change new era demanding policy financial behavioural innovations accelerate transition clean energy economy dramatic price decreases solar public policy expansion solar power now accounting largest share renewable energy california rising fast countries germany italy governments efforts expand solar generation base integrate municipal regional national energy systems several programs require rigorous policy evaluations assess effectiveness costs contribution paris goals study exploit natural experiment northern california test capacity property assessed clean energy pace promote investment pace highly cost effective residential elsevier ltd rights reserved
main objective study analyse outcomes total knee arthroplasty group patients least one self reported allergy group patients without reported allergies hypothesized significant negative influence clinical outcome scores patients self reported allergies four hundred seventy five patients undergone analysed preoperatively year surgery scores obtained patients depression questionnaire score also recorded scores patients without self reported allergies compared scores patients least one self reported allergy medical record preoperative scores similar groups post operative scores knee score worse group patients self reported allergies group without allergies scores depression questionnaire similar groups patients least one self reported allergy worse post operative outcomes terms knee scores patients without allergies poor outcomes seem related depression therefore research needed explain reported allergies considered prognostic factor used counselling patients
variety catalysts recently developed oxygen evolution readily integrated light photocatalytic water splitting demonstrate efficient core highly active oxygen evolution semiconductor core oxygen evolution reaction metal organic chemical vapor deposition single source precursor used ensure good contact core reaches theoretical density reversible hydrogen electrode simulated sun irradiation dramatic enhancement result synergistic effects high oxygen evolution reaction activity delivering slope conductive surface active sites semiconductor core interfacial charge transfer collection facile fabrication core array offers compelling strategy preparing highly efficient solar energy conversion devices
article examines social construction gender gender roles city gendered household roles related food security interviews men women revealed distinct set word gender reflected historical contemporary engagement concepts development human rights concept gender gender order distinguish word participants used interviews widely accepted conventional definition use distinction highlight ways ideas gender equality introduced received context urban setting research key drawing association gender bringing focus power dynamics inherent project translating global discourses gender rights gender equality meaningful social change developing countries gender top outside process framing goals gender equality creates political constraints form resistance gender long history social change imposed outside forces form superficial adherence gender appear urban modern especially western researcher local understandings gender gender undermine efforts promote gender equality means address intense urban poverty household food insecurity social los roles los roles con con con los con los con mas para ideas han para con los los los vertical los con social superficial para mas los
rapid developments computer technology information technology human machine interfaces nuclear power plants command system complex information systems evolved traditional control mode digital control mode visual information interface paper studies error factors information interface human computer interaction based visual cognition theory feasible error cognition model established solve design problems result serious failures information recognition analysis even operation execution processes based reason error types cream failure identification models performed classification cognitive characterization error factors according information search information recognition information identification information selection judgment decision making process obtained comprehensive error cognition model complex information interface
weather becoming one biggest problems many big cities china triggers public anxiety official concerns particulate matter plays important role causing adverse health effects chemical composition includes primary particles secondary particles toxicological mechanisms human body include oxidative stress inflammation carcinogenesis short long term exposure especially cause series symptoms including respiratory symptoms cough symptoms positive associations mortality due number causes considered contribute onset asthma exacerbation chronic obstructive pulmonary disease copd weather approaches including outdoor health care indoor health care preventive medications prevent patients chronic airway diseases exacerbations
recent experiences indicate already reported types cancer circulating tumor cells play role also non small cell lung cancer nsclc diagnosis therapy monitoring prognostic purposes evaluation particularly relevant clinical setting objective difficulty obtaining tumor tissue also lack reliable tumor markers current review focus possible applications nsclc patients elsevier ireland ltd rights reserved
nanotechnology material surface modification provided functional platform advancement several medical fields dermatology furthermore smart choice preparation material proven confer unique properties context focused whose deficiency found negatively affect psoriasis doped surfactant based systems create vesicles loaded model anti psoriatic drug properties tested compared free vesicles characterized drug viscosity vitro drug release morphology vivo drug skin deposition thermal behavior clinically tested psoriatic patients factorial design study revealed surfactant type surfactant ratio presence ethanol hydration buffer affected efficiency viscosity vesicles increased decreased release enhancing deposition within skin correlating better clinical therapeutic outcome compared topical product also able cause significant membrane vesicles causing conventional spherical morphology conclusion present new functional treatment modality psoriasis future experimentation elsevier rights reserved
atypical femur fracture serious complication long term therapy usually preceded incomplete fracture appearing lateral femur likely result severely suppressed bone turnover however differences bone structure turnover patients incomplete complete remain unknown examined trans bone biopsies white postmenopausal women incomplete complete therapy years healthy white premenopausal women measurements performed separately measurements difference bone surfaces bone resorption variables surface significantly lower patients complete incomplete compared healthy premenopausal women trabecular bone volume thickness number significantly lower patients dynamic bone formation variables patients significantly reduced bone surfaces likelihood biopsy labeling significantly higher patients healthy premenopausal women based results conclude significant differences bone turnover patients incomplete complete suggesting suppression bone turnover already existed femur incomplete compared healthy premenopausal women bone turnover similarly suppressed patients either type
predicting location protein within cell important cell biology computational approaches issue attracted community among protein features used predict subcellular localization proteins feature derived gene ontology shown superior others however field set presence absence predefined terms proposed method derive information intrinsic structure graph feature vector constructed element representing information content term protein investigated support vector machines used classifier test extracted features evaluation experiments conducted three protein datasets results show method enhance eukaryotic human subcellular location prediction accuracy better previous studies also used based features especially scenario cellular component annotation absent method achieved satisfied results overall accuracy elsevier ltd rights reserved
acetate progesterone derivative first synthesized used progestin based hormone replacement therapy since first used oral contraception combined estradiol exerts potent effect one third higher observed endogenous progesterone also anti estrogen showing effects birth control dose unlike progesterone mild effect anti effect biological actions allowed role therapeutic use contraceptive agent addition exhibited beneficial neuroendocrine effects womens mood combination shown excellent contraceptive efficacy high tolerability compliance due risk benefit profile additional benefits skin hair reduction metabolic tolerance demonstrated several clinical studies currently formulated taken oral package containing per pill without seven placebo additional pills another presentation containing plus four placebo pills
laser stealth space target useful important urgent practice paper introduces definition expression laser radar cross section general laws influencing factors space targets including surface materials types targets shape size paper discusses possible laser stealth methods space target practical applications two view points material stealth methods shape stealth methods conclusions suggestions provide references next research thinking methods targets laser stealth
paper improved phi expansion method proposed seek general exact solutions new partial differential equation concise straightforward method applied equation exact particular solutions containing four types hyperbolic function solution trigonometric function solution exponential solution rational solution obtained solutions comparing methods recently method developed searching exact traveling wave solutions nonlinear partial differential equations abundant exact traveling wave solutions including solitons periodic rational solutions found solutions play important role engineering physics fields shown method help symbolic computation provide straightforward powerful mathematical tool solving problems nonlinear optic elsevier gmbh rights reserved
purpose knowledge regarding environmental impacts agricultural systems required consideration uncertainty life cycle assessment lca provides additional scientific information decision making aims study compare environmental impacts different growing tomato cultivation scenarios mediterranean conditions assess uncertainty associated different agricultural production scenarios materials methods burdens associated tomato production calculated evaluated lca methodology functional unit chosen study mass unit commercial loose study included quantitative uncertainty analysis monte carlo simulation three scenarios considered greenhouse open field flows processes product scenario structured several sections structure auxiliary equipment crop management pesticides waste management six impact categories selected relevance climate change terrestrial marine metal depletion fossil depletion using impact evaluation method using results discussion structure auxiliary equipment produced largest environmental impacts tomato production greatest impact stages found manufacture drawing steel structures manufacture amount used electricity consumed irrigation system manufacture application cropping scenario largest environmental impact categories varying higher respectively metal depletion higher showed highest uncertainty bandwidth probability higher respectively conclusions lca used improve identification evaluation environmental burdens tomato production mediterranean area study demonstrates significance conducting uncertainty analyses comparative used comparative relative product environmental impacts
machine vision technologies hold promise enabling rapid accurate fruit crop yield predictions field key fulfilling promise accurate segmentation detection fruit images tree paper proposes two new methods automated counting fruit images tree one using texture based dense segmentation one using shape based fruit detection compares use methods relative existing techniques method based nearest pixel classification contour segmentation method based super pixel segmentation classification using support vector machines robustness algorithm tested multiple sets images trees acquired period years image sets acquired varying conditions light exposure distance tree average number fruit tree season images collected conditions calibration images estimated fruit numbers within actual fruit numbers measure detection performance methods results poorer models used estimating fruit numbers trees different canopy shape different imaging conditions used fruit background segmentation nearest pixel classification based colour pixel classification based super pixel segmentation clustering dense scale invariant feature transform features visual words bag visual word super pixel classification using support vector machines effective simple contrast colour based segmentation pixel classification best followed fruit detection using shape model detection using colour filtering morphological image processing techniques method results also compared using precision recall plots imaging night artificial illumination careful attention maintaining constant illumination conditions highly recommended
cancer multifactorial disease network genes causing genetic alterations sophisticated techniques molecular biology revealed different cancer pathway mechanistic approach still tumor necrosis factor tnf related apoptosis inducing ligand receptors emerged potential target drug cancer therapy among natural products fungus constituents plethora activities modulating signaling cancer acid skeleton play role modulating signaling cascades various pathways present study receptor based molecular docking performed study dynamic behavior complexes molecular interactions acid isoforms tumor necrosis factor receptor top scoring compounds compared already documented natural inhibitor tumor necrosis factor binding affinity absorption distribution metabolism excretion toxicity properties acid interact promising compared isoforms mol bond involvement residues binding tumor necrosis factor docking acid acid exhibits involvement hydrogen bonding residues natural inhibitors already documented exhibit low binding energy docking parameters edge acid tumor necrosis factor acid efficiently inhibits proliferation viability intracellular reactive oxygen species messenger rna expression tumor necrosis factor breast cancer cell lines
propose novel framework stereo low light conditions using near light illumination operates free form video sequences captured affordable setup address issues variations perspective projections camera noise method uses spheres detected perspective correcting transform robustly light positions presence outliers via least squares approach furthermore propose iterative scheme combination norm robustly solve calibrated near light problem contrast approaches framework depth relative light source intensity simultaneously demonstrated synthetic real world scenes
paper presents study collective knowledge information technology comparative analyses innovative trends roads knowledge software engineering focus amount required innovation necessary examples database standardised units improvement information systems goal determine obtain appropriate knowledge model excellence contribution modelling excellence plan check act presented elsevier rights reserved
selecting right technology given application critical future enterprise companies year new technologies intended provide competitive advantage many attempts technology selection process sufficiently focused technology many processes simply add layer complexity already difficult process developed three stage technology selection tool provides framework simple risk managed process evaluating selecting new technologies tool provides powerful visual aid help clarify key attributes various technologies decisions related adoption illustrating team members senior management decision making processes engaged project managers considering new technologies three stage filter tested new product development project leading company seeking smart material technologies drive strategic innovation
period lung respond dramatic changes circulating hormones nutritional factors physiologic signals transition becoming organ gas exchange protein synthesis consumes significant proportion metabolic resources inhibited many environmental stresses hypothesized translational control mechanisms play role perinatal lung late gestation fetal day rat lung extracts revealed gradual decreases phosphorylated forms mammalian target rapamycin effectors eukaryotic initiation factor binding protein kinase ribosomal protein followed sharp increases postnatal day immunohistochemistry showed staining prominent epithelial cells large small airways experiments showed decrease association translation initiation factor inhibitor binding protein concomitant increase association immediately birth profiles confirmed decrease abundance large reversed microarray analysis versus total rna lungs used identify specific genes association large changed either pre pcr northern blotting used confirm translational changes selected candidate genes including prenatal increase postnatal decrease regulatory subunit protein phosphatase translational regulation protein phosphatase regulatory inhibitor subunit gene specific changes contrast corresponding global changes abundance
past research shown activation aggressive cognitions memory media violence exposure examined priming effects viewing relational aggression media current study women viewed video depicting physical aggression relational aggression aggression subsequent activation physical relational aggression cognitions measured using emotional task results indicated priming relational aggression cognitions viewing aggressive video activation physical relational aggression cognitions viewing physically aggressive video results discussed within framework general aggression model wiley periodicals inc
typical variable air volume terminals spend majority time minimum airflow set points often higher minimum ventilation requirements defined code resulting excess energy use risk cooling spaces developed tested time averaged ventilation control strategy institutional building campus address issue whenever zone require cooling damper partially open fully closed average airflow matches predefined ventilation compared existing base case scenario using single max logic strategy reduced mean zone airflow fraction intervention period corresponding reductions average heating cooling fan power respectively addition programmed directly native control system applied via low cost strategy building network direct digital control terminal elsevier rights reserved
interaction hiv human novel determinant chronic immune activation liver fibrosis progression highly active antiretroviral therapy significantly improved prognosis hiv infected subjects however patients treated long term still manifest increased mortality even undetectable plasma often experience persistent immune activation furthermore liver related mortality now common cause non aids related death hiv infected individuals highly active antiretroviral therapy accelerated fibrosis progression first line host response pathogens play important role human host defense viruses sensing viral structural proteins growing evidence points key player chronic immune activation hiv recognition replication liver fibrosis progression suggesting hiv triggering aspects multifaceted aids pathogenesis study provide evidence interplay host hiv human monocyte derived macrophages hepatic cells leading intracellular pathways biologic activities mediate proinflammatory signals finally hypothesize likely part common receptor cluster blocking specific antagonists impairs macrophage capacity produce chemokines response lps chronic immune activation liver fibrosis remain important obstacles highly active antiretroviral therapy success thus identification axis novel determinant immune system hepatic cell biology opens new perspectives management hiv infection disease
considering major requirements automotive applications high torque power density low torque ripple wide speed range high speed operation capability synchronous reluctance machine still intensive investigation traction motor proper operation low high speeds desired magnetic mechanical performance core structure important challenges therefore prior final design need analyzed regards core magnetic behavior mechanical robustness cause degradation torque quality harmful deformation critical points rotor structure low speed high current demand maximum torque makes core magnetic performance dominant whereas high speed mechanical behavior rotor core structure limits machine performance paper presents comparative analysis different core characteristics improve core magnetic mechanical performance equipped anisotropic rotor type automotive applications
paper presents new variable speed wind energy conversion systems based six phase cage induction generator matrix converter power electronic interface six phase electrical network analysis employs rotor flux vector control algorithm scalar strategy modulated control generator characteristics used maximizing power tracking control different wind speeds delivering powers grid simultaneously considered provides sinusoidal input output voltages unity power factor causes asymmetry generator current control strategy including method suppressing imbalance caused asymmetry discussed numerical simulations carried showing effectiveness proposed topology
vigorous spread renewable energy much attention paid natural ventilation natural usually classified passive type active type study type one passive type basically operated principle experimentally investigated evaluate ventilation characteristics according outdoor wind velocities opening area wall confirmed experimental results ventilation rate type linearly increased ventilation rate affected intake opening area wider intake opening size gets ventilation rate increases furthermore new coefficient reflects pressure loss intake opening mixing zone type introduced experimentally evaluated value beta evaluated provides simple calculation means estimate ventilation rate type geometric dimensions known elsevier rights reserved
research investigated relevance four hydrological variables performance domestic rainwater harvesting system hydrological variables investigated average annual rainfall precipitation concentration degree antecedent dry weather period ratio dry days rainy days principal component analyses used group water saving efficiency select set variables relevance hydrological variables water saving efficiency system studied using canonical correlation analysis associated attained better correlation water saving efficiency single conclude empirical models represent large combinations roof surface areas rainwater tank sizes water demands rainfall regimes also consider variable precipitation temporal variability treat independent variable elsevier rights reserved
objective although majority women serious mental illnesses mothers limited research available relationship maternal pediatric health care use adherence preventive care associated improved childrens health also decreased costs health care system study examines relationship maternal psychotic disorders pediatric health care method retrospective secondary analysis medicaid claims compares age cohorts children years mothers without bivariate multivariate logistic regression models used examine established measures pediatric preventive care emergency department care among mother child dyads results adherence preventive care guidelines ranged among mothers among mothers without mothers times likely least one preventive care visit year times less likely least one visit year significantly likely high reliance children ages years conclusions differences existed pediatric health care use among medicaid insured mothers without although preventive pediatric health care use among mothers comparable mothers without mothers mental illness still benefit targeted strategies reduce reliance young children years social work involvement families living poverty help families access use preventive care young children
described syndrome physical features include deep set eyes turned mouth mild skeletal anomalies including terminal report infant born typical features syndrome additional features include extreme joint total anomalous pulmonary venous return revealed unbalanced chromosome complement specifically derivative chromosome novo unbalanced translocation chromosomes resulted partial deletion long arm chromosome proximal band fluorescence situ hybridization studies methylation analysis southern blotting revealed deletion locus derived chromosome consistent syndrome infant represents first reported case syndrome total anomalous pulmonary venous return amygdala hippocampus additional finding syndrome resulting derivative chromosome arising unbalanced novo translocation wolters kluwer health
digital proposed enhanced traditional psychological play therapy digital sensors computer graphics combined together obtains significant difference reaction children compared normal proposed approach connecting concrete object information humans several sensors presents several representative image display virtual assume virtual approach specific effect improving biological reaction children also adult try conducted experiments proposed device method implemented experimental obtained knowledge effect virtual approach
large body experimental clinical evidence complement activation contributes glomerular injury multiple different diseases however underlying mechanisms trigger complement activation vary disease disease immune complexes activate classical pathway complement many types whereas alternative pathway binding pathways directly activated diseases inhibitory antibody approved treatment atypical syndrome case reports suggest also effective types furthermore new complement inhibitory drugs developed target additional proteins within complement cascade raising possibility blocking specific complement proteins involved given disease review examines rationale targeting different proteins within complement cascade new anti complement drugs currently development challenges investigators face bringing drugs clinic
studies war exposed children investigated comprehensive array resilience promoting factors representative samples children adolescents representative sample adolescents randomly selected communities recently exposed war experienced war trauma administered questionnaires measuring war exposure family violence availability leisure activities school related problems interpersonal peer problems socialization daily routine problems displacement availability parental supervision contact medical needs coping skills related religious coping denial self control avoidance problem solving mental health measured strengths difficulties questionnaire child revised impact events scale resilient adolescents defined experienced war trauma manifest symptoms resilience related male using problem solving techniques leisure activities parents spent time adolescents supported school work interventions designed war youth build individual coping skills children adolescents yet time target parents teachers integrated manner
project presents new approach operated mobile platform using robot robotics chosen versatility wide range movements allows perform various tasks steering simple programming algorithm system integration mobile platform done using arduino microcontroller interface project consists several parts paper focuses implementation developed control system integration new mobile platform improvement previous research integrate laser range navigation system shows good result platform able avoid obstacles conduct obstacle avoidance experiment result shows new platform suitable fit handling navigation authors published elsevier
natural product chosen study structure activity relationships group antitumor antibiotics due similar chemical structure comparable bioactivity principle compound group feasibility enzymatic modifications sugar moiety auxiliary enzymes used modify interaction drug histone biological target interacts sugar moiety cytotoxicity assays revealed free group sugar moiety essential maintain bioactivity apparently important hydrogen bond donor interaction histone converting group improved bioactivity bis methylated derivatives revealed weaker activity parent compound indicating least two hydrogen bond donors sugar necessary optimal binding
identifying processes human cultures spread across populations one topical objectives shared among fields study works analyzed variety data attempted determine whether empirically observed patterns result cultural special issue articles exploring several themes modes cultural transmission drivers dispersal mechanisms contexts europe spread computer programming languages new insights augment theoretical empirical basis study cultural introduction outline state art modeling processes briefly discuss pros two commonly used frameworks equation based models agent based models summarize significance article special issue
paper adaptive fuzzy controller design methodology via multiobjective particle swarm optimization based robust stability criterion proposed plant controlled modeled input output experimental data considering fuzzy model using fuzzy means clustering algorithm antecedent parameters estimation weighted recursive least squares algorithm consequent parameters estimation adaptation mechanism problem online tuning fuzzy model based digital pid controller parameters based gain phase margins specifications formulated experimental results adaptive fuzzy digital pid control thermal plant time varying delay presented illustrate efficiency applicability proposed methodology
activities lipase human pancreatic dog gastric first compared using stabilized tag various bile salt concentrations like able tag droplets covered monolayer directly active substrate results good agreement respective kinetics adsorption films three lipase adsorption onto monolayer spread air water interface influenced dependent changes enzyme lipid interfacial association constant ads optimum long chain egg monolayer medium chain film using substrate displayed highest activities substrates surface pressure range active large range displayed dependent activity profile combining features values found stomach intestine respectively apparent maximum activity observed acidic therefore correlated efficient interfacial binding levels type interfaces substrate findings support use enzyme replacement therapy treatment pancreatic insufficiency pathological situation intestinal contents occurs elsevier masson sas rights reserved
simple object access protocol among techniques implements web services offers lightweight simple mechanism exchange structured information among computing devices decentralized distributed computing environment however data extensible language xml format xml documents huge size thus becoming major performance high performance applications process lots data paper develop implement evaluate performance optimization aggregated architecture disadvantaged network bandwidth aggregated architecture client side document web services description language description simple database queries server side compression technique experimental results showed relatively high time low network throughput nevertheless improved performance evident terms bandwidth utilization transfer time useful disadvantaged networks
pathogenesis coronary artery disease cad multi factorial several conventional risk factors ascribed ldl one important risk factor however indian population studies established cad often show ldl levels within normal range patients proven cad hypothesized small dense low density lipoprotein correlate strongly occurrence severity cad aim study evaluate association serum small dense ldl level documented coronary artery disease cross sectional case control study measured patients cad patients without cad total cholesterol hdl cholesterol ldl cholesterol triglycerides measured standard methods along traditional risk factors direct quantitative measurement done enzymatic analysis mean level higher patients coronary stenosis patients without coronary stenosis respectively significant correlation mean severity cad assessed syntax score mean level low intermediate high syntax score respectively value cut value associated presence cad using roc curve conclusion indian patients established cad higher levels compared individuals without cad despite comparable ldl levels
system presented creating real time natural television image composed real scene computer graphics object light positions colors rgb values real scene estimated applied object using simple equipment objective subjective experiments demonstrated effectiveness system enhanced algorithm also presented improves accuracy light estimation
ulipristal acetate upa new selective progesterone receptor modulator used emergency contraception however understanding mechanisms action limited present study focused vitro effects upa mol steroid receptors human tubes beat frequency levels steroid receptors measured effects upa progesterone induced reduction also studied results show upa dose dependently progesterone induced decrease affect upa also expression levels estrogen receptor tubes results enable better understand mechanisms upa works emergency contraceptive provides scientific basis clinical application
paper innovative method presented identify models modified frequency domain subspace method new approach allows introduce subspace resolution constraints identified model poles location general formulation proposed take account regions continuous discrete map formulation based linear matrix inequalities description stability domain represents particular case constraints combined frequency domain subspace resolution obtain identified models whose poles situated specified regions approach one belongs class frequency domain input output model identification approximation methods besides fact belong data driven model approximation class result slightly different objectives show complementary performances discussion illustrated practice performed identification control disturbance wing span sub wind tunnel facility
developmental lead exposure suggested laboratory studies trigger neurodegenerative diseases alzheimers disease related receptor class repeats containing recently identified genetic risk factor limited characterization vertebrate models comparison genetic risk factors characterize protein sequence homology humans mice zebrafish analyzed showed conservation functional repeats domain orientation next spatial expression zebrafish larvae completed diffuse expression neural tissue restricted brain observed influences sex age quantitative expression brain adult zebrafish assessed sex specific alteration expression aging process females zebrafish utilized investigate impacts embryonic exposure expression known genetic risk factors sex specific quantitative gene expression analysis completed adult zebrafish brain compare developmentally exposed control treatment significant difference expression genetic risk factors observed overall study provided characterization changes brain expression aging female specific finding agreement females prone onset analysis additional genetic risk factors needed facilitate understanding impact embryonic exposure copyright john wiley sons ltd
evidence support role cerebellum emotional learning processes altered patients chronic pain tested cerebellar activation altered visceral pain related fear conditioning extinction irritable bowel syndrome ibs cerebellar blood level dependent data ibs patients healthy controls collected part previous fmri study utilizing advanced method cerebellum differential fear conditioning paradigm consisted acquisition extinction phases acquisition two visual conditioned stimuli presented either paired painful rectal stimulus extinction phase presented without presentations followed presentations group differences cerebellar activation analyzed contrasts acquisition ibs patients revealed significantly enhanced cerebellar responses pain predictive safety cues compared controls pcs group differences prominent contrast extinction significant group differences found visceral pain related fear conditioning ibs patients showed increased activations areas medial intermediate lateral cerebellum areas involved autonomic somatosensory cognitive functions likely contribute different aspects pain related fear cerebellum contributes altered pain related fear learning ibs
aim determine prevalence symptoms eating disorders overweight obesity population students city methods epidemiological cross sectional study used self administered questionnaire assessment eating disorders body image dissatisfaction bullying gender age number daily meals total body mass height also collected study results study found individuals symptoms eating disorders overweight obese excess body fat associated symptoms eating disorders victims bullying almost times likely overweight individuals performed meals showed less likely overweight conclusions results similar cities country world showing need preventive measures
scope predictive adaptive response hypothesis suggests utero environment post environment influence later life health underlying mechanisms poorly understood involve gene transcription changes regulated via epigenetic mechanisms methods results factorial design female mice randomised low normal diets acid diet prior pregnancy lactation offspring randomised high low fat diets weaning genome wide gene expression promoter dna methylation measured using microarrays adult male livers maternal depletion high fat intake post weaning influenced gene expression genes respectively promoter dna methylation loci respectively changes expression methylation poorly matched dietary interventions expression genes altered response maternal depletion post weaning high fat feeding treatments imposed separately addition evidence combined dietary maternal depletion followed high fat post weaning caused largest expression change genes conclusion observations align provide evidence support potential underlying mechanism predictive adaptive response hypothesis
background atopic dermatitis inflammatory disease skin characterised chronic relapsing course aim aim study assign prevalence clinically active food allergies among group children months years age methods eighty eight children screened specific ige antibodies food proteins patients specific ige antibodies food proteins subjected oral food challenges relevant foods results food patients moderate levels clinically active food allergy milk egg basis positive high ige prevalence almost regardless concomitant food disease severity conclusions study clinically active food allergies recognised children nevertheless association confirmed food severity high ige peripheral found prevalent among children severe among children food infants younger children screened underlying food allergy regardless disease severity published elsevier espana slu rights reserved
background aim irritable bowel syndrome ibs common functional gastrointestinal disorder commonly diagnosed one study aim explore frequency ibs among medical students factors associated disorder among materials methods cross sectional study carried among medical students academic levels three local universities region university colleges medicine data study collected throughout semester academic year using validated self administered anonymous paper questionnaire questionnaire included three main sections demographics rome iii criteria hospital anxiety depression scale results among students completed study ibs senior medical students times likely ibs depression significantly associated ibs stepwise logistic regression showed chronic health problems advanced academic level personal history ibs significant predictors ibs conclusion prevalence ibs among medical students region depression age living situation advanced academic years family personal history episode diarrhoea main predictors ibs offering psychological emotional support along stress management courses order deal stress recommended
control wave energy converters often limited hydrodynamic control absorb maximum energy possible ocean waves generally significantly simplifies performance real power take systems however including required dynamics constraints control problem considerably vary control strategy power output therefore paper considers incorporation model conversion stages ocean waves electricity network referred wave wire models identifies necessary components dynamics constraints including grid constraints addition paper identifies different control inputs different components system inputs articulated dynamics system examples pneumatic hydraulic mechanical magnetic transmission systems driving rotary electrical generator linear electric generators provided
human discovered date http still remain sense function expression sites regulation still largely elucidated genome sequencing project era presented research community novel challenges despite many insights gathered gene location genetic variations human genome still lack important knowledge novel enzymes functions endogenous exogenous metabolism possible roles metabolism list currently consists members already putative assigned functions acid metabolism activate however point majority knowledge available genes single nucleotide polymorphisms biological functions noteworthy express high sequence conservation rodents review summarizes recent knowledge questions remaining specific roles human metabolism
background objective idiopathic pulmonary fibrosis ipf progressive disease poor prognosis variable clinical course although matrix metalloproteinase mmp emerging important ipf biomarker reproducibility across studies unclear aimed determine whether previously reported prognostic threshold mmp predictive mortality independent cohort ipf patients methods mmp concentrations obtained plasma samples determined elisa patients ipf healthy controls association previously published heparin plasma mmp threshold cause mortality transplant free survival determined either independent biomarker part modified personal clinical molecular mortality index results mmp plasma concentrations significantly higher ipf patients compared healthy controls plasma mmp threshold significantly associated cause mortality unadjusted cox proportional hazard ratio respectively mmp concentrations split significantly predictive mortality adjusting age gender smoking baseline pulmonary function parameters multivariate cox proportional hazards model mmp concentrations negatively correlated lung capacity carbon monoxide positively mortality risk scoring system gap combines age gender forced vital capacity fvc conclusion study confirms mmp concentrations used accurately predict outcomes across cohorts centres similar collection protocols applied
past ten years human identification received increased attention computer vision research community however part research papers context algorithms used real world system paper describes unique opportunity group academic researchers design deploy human identification system demanding real world environment system designed ground including robust modules human detection tracking distributed low latency software architecture front end user interface designed specific scenario none issues typically addressed identification research papers critical effective system end users actually willing adopt detail challenges real world environment computer vision algorithms underlying human detection identification algorithms robust software architecture ground system required provide training validation data algorithms initial results show despite challenges constraints environment proposed system achieves good performance operating real time
pregnancy birth survey started medical university part health management survey order assess physical mental health mothers provide parenting support telephone counseling need present study reviewed major findings annual surveys conducted overall proportions preterm low birth weight infants congenital anomalies first year almost national surveillance data prevalence depressive symptoms among mothers held steady years regarding content parenting counseling proportion mothers concerns radiation decreased year survey continued provide support mothers
biogas fired tri generation system cooling heating electricity generation supported photovoltaic system discussed analyzed energetic ecological effectiveness point view analyzed system based internal combustion engine adsorption machine evaluation primary energy savings aided system indicators total primary energy savings relative primary energy savings defined also analysis carried reduction greenhouse gases emission ecological potential evaluation environmental impact indicator total greenhouse reduction taken account presented detailed algorithm evaluation system global balance boundary applied analysis energy effects consumption primary energy ecological effect emission greenhouse real data hour hour year operation taking account random availability renewable energy allows take account important factor characterized renewable energy systems res variability random availability case photovoltaic primary energy particularly presented work effects analysis application discusses algorithms demonstrated hour hour availability solar radiation daily changing availability chemical energy biogas additionally energy ecological evaluation algorithms integrated methods offered exergy analysis case systems problem allocation fuel useful products heat electricity commonly applied methods energetic division take account different quality products generated unit moreover methods require subjective assumptions lead cases non physical results fuel allocation commonly known exergy losses decide amount consumed energy driving production process considered process two products generated losses allocated products reason correct allocation also done application allocation proposed algorithm presented paper elsevier ltd rights reserved
background study reports analysis application diagnostic revised criteria cohort patients organ associations patterns disease methods retrospective cohort study conducted using database electronic medical records three categories recognised clinically defined incomplete rejected diagnoses applied classification criteria subgroups validate diagnostic accuracy multidisciplinary assessment results patients underwent initial assessment urban tertiary care centre patients confirmed diagnosis incomplete diagnosis rejected diagnosis demonstrated estimated sensitivity positive likelihood ratio strongest independent predictors central nervous lesions genital retinal vasculitis anterior posterior conclusions criteria sensitive cases using multidisciplinary assessment gold standard diagnose population patients incomplete form represent distinct group given early diagnostic label disease complex disease best diagnosed multidisciplinary clinical assessment patients differ clinical presentation genetic susceptibility original descriptions study also highlights incomplete group patients less defined clinical presentation
background first evidence based clinical practice guidelines principles care people dementia australia released guidelines detail number important evidence based recommendations occupational therapists aim paper provide overview guideline development describe evidence supporting recommendation occupational therapy common characteristics effective occupational therapy programmes people dementia described development involved adaptation existing high quality guidelines developed systematic reviews ensure recent high quality evidence included one systematic reviews involved examining evidence interventions promote independence people dementia specifically looked evidence occupational therapy effect activities daily living quality life impact resultsa total recommendations included guidelines occupational therapy found significantly increase independence activities daily living improve quality life effective occupational therapy programmes involve environmental assessment problem solving strategies education interactive skills training therapists working people dementia community settings ensure time spent aspects intervention shown effective
purpose atopic dermatitis chronic dermatitis high prevalence diverse clinical features although several hypotheses multifactorial pathogenesis suggested cause yet fully understood better understanding clinical features helpful pathogenesis methods retrospective study analyzed questionnaires medical charts laboratory examination results patients diagnosed tertiary hospital korea results demographics allergic comorbidities family history severity treatment experiences patients analyzed patients adults classified extrinsic type mean eczema area severity index score found adult patients found higher severity age groups anatomical different among age groups head neck adults patients reported seasonal changes stress factors symptoms topical steroids oral used medications clinic whereas patients underwent allergen specific immunotherapy conclusions analysis patients lead better understanding various subtypes diverse clinical features distinct characteristics observed among different age groups thus treatment strategies need differentiated accordingly
eating disorders hold unique place among mental health disorders salient symptoms objectively observed measured rather determined patient interviews subjective evaluations measurement advantage alone evidence based medicine expected make rapid however conclusions eating disorders research medical research literature often continue misleading ambiguous one major long known source problems misuse statistical significance values throughout research papers like much problem become systemic rather corrected peer review system discussion attempts clarify issues suggest readers deal issue processing research literature
existing analytical solutions steady state temperature field straight row artificial ground cover single multi single row double row yet sufficient meet needs construction projects triple row even multi row increasingly adopted paper original engineering problems temperature field single row firstly converted solving plain laplace equation specified boundary conditions based superposition thermal potential analytical solutions steady state temperature field single single row double row deduced solution triple row obtained validated comparison thermal numerical analysis furthermore formula calculating thickness triple row frozen soil wall proposed important construction management artificial ground elsevier ltd rights reserved
discovery rise graphene historically enabled similar optical contrast specialized substrates like oxide silicon however substantially lower contrast obtained transparent substrates moreover remains difficult visualize nanoscale defects graphene including cracks device substrates report use interference reflection microscopy facile label free optical microscopy method originated cell biology directly visualize graphene transparent inorganic polymer substrates image contrast per graphene layer noninvasive approach overcomes typical challenges associated transparent substrates including rough surfaces enables identification local graphene layer numbers reveals nanoscale structures defects outstanding contrast throughput thus demonstrate situ monitoring nanoscale defects graphene including generation strain video rate
despite widely accepted concept probiotics confer benefits hosts controversies surrounding health promoting claims ignored controversies hinder development innovation field clarify effects age gender probiotic induced immune responses recruited taiwanese individuals calculated ratio ifn gamma production individuals pbmcs stimulated six probiotic strains results indicated gender age minor effects immune modulation probiotics additionally showed two dominant strains inducing ifn gamma production taiwanese individuals effective ifn gamma additionally significant inverse relationship ability stimulate ifn gamma ifn gamma production also observed results indicated age gender minor effects immune modulation abilities probiotics
paper focuses learning post processing composite materials current context manufacturing engineering education spain use composites significantly increased different sectors industry last decades students taking manufacturing courses engineering study plans need basic formation concerning post processing composites due complexity process powerful numerical tools needed develop practical models focused damage prediction learning skills include modeling anisotropic materials specific concepts composite machining induced damage
emotion reactivity emotion regulation salient constructs theories emotion emotion disorders however little known convergent discriminant validity instruments used measure current paper examines validity four emotion regulation three emotion reactivity instruments total subscales across three independent samples university students total eight subscales coping instrument also examined confirmatory factor analysis failed show expected patterns convergent discriminant validity however exploratory factor analysis revealed three different factors reflecting control negative emotion emotion awareness expression cognitive strategies emotion regulation results implications basic emotions research clinical science elsevier ltd rights reserved
four studies tested support idea implicit theories versus gender roles entity incremental theories predict differences degree gender system justification support status relations women men society relative incremental theory holding entity theory correlated system attitudes self perceptions study men women alike also found strength identification ones gender group stronger predictor system justification men women suggesting mens defense status motivated membership high status group social hierarchy experiments tested whether exposure fixed gender role theory lead men identify masculine characteristics male gender group thus increasing defense gender system fair just expect fixed gender role theory trigger identity motivated responses women overall found increasing degree psychological investment masculine identity adopting fixed gender role theory increased mens gender status compared gender roles perceived suggests men motivated align masculine identity likely endorse persistence gender inequality way status real men
application basal reinforced earth structures approved method particularly traffic route engineering technique transferring static variable loads soil layers low bearing capacity soft clay deeper soil layers amongst others like recommendations design analysis earth structures using geosynthetics german society provides recommendations calculation design execution reinforced earth structures recommendations based specific geometrical mechanical load related boundary conditions fully geotechnical applications traffic route engineering objective often minimize height bearing layer reinforced earth structure technical optimum reinforced base layer becomes essential predict stability arch also due cyclic loading effects surface deformation bearing layer reliable way paper presents results three dimensional numerical simulation single layered reinforced quasi static cyclic loading compares stress distribution geogrid current analytical methods
incidence breast cancer rise sub saharan africa efforts early diagnosis successful public scant knowledge disease large percentage breast cancer cases diagnosed late mainly rural womens practice breast self examination poor paper argue examination social cultural contexts influence breast cancer diagnosis management region needed discuss implications sociocultural factors gender roles breast cancer diagnosis management
fast fourier transform algorithms large data sets achieve poor performance various platforms inefficient memory access patterns inefficient access patterns need achieve high performance implementations paper formally targeting generic machine model two level memory hierarchy requiring block data transfers derive memory access pattern efficient algorithms using custom block data layouts algorithms need carefully mapped targeted platforms architecture particularly memory subsystem fully utilize performance energy efficiency potentials using product formalism integrate optimizations framework evaluate family optimized fft algorithms hardware implementation design space via automated techniques evaluations demonstrate optimized accelerator designs large tradeoff space given various problem single double precision hardware platform chip stacked asic fpga etc parameters show generated pareto optimal designs achieve close theoretical peak performance targeted platform offering system performance power efficiency improvements respectively conventional row column fft algorithms
paper presents new approach develop remote practices systems engineering automatic control laboratories based easy simulations used create laboratory front end students observe behavior controllers systems study web tablets smartphones low cost single board computer charge running program control loop selected plant laboratory web server hosts laboratory front end controller finally development runtime platform used develop run laboratory web within support communications laboratory front end server new strategy tested proportional integral differential pid controller vertical mono rotor plant provides low cost real time support controller friendly remote access mobile devices practices students ifac international federation automatic control hosting elsevier ltd rights reserved
much literature examined immigrants health canada less attention focused specifically life stress important yet understudied post migration challenge lead poor coping strategies negative health consequences study pooled canadian community health survey analyzed using multilevel logistic regression examine effects individual level effects level reported high life stress separate models run immigrants non immigrants comparative purposes results reveal different ways select individual socioeconomic lifestyle factors affect life stress statistically significant yet small effect level life stress identified immigrants non immigrants comparing immigrants non immigrants factors smoking length canada mental health status found particularly informative predicting high life stress among immigrants healthy immigrant effect partially evident immigrants longer stay canada likely highly stressed recent effect high life stress minimal suggesting importance focusing individual level effects stress predictors
diurnal animals better model seasonal affective disorder sad nocturnal ones previous work diurnal rodents demonstrated short photoperiod conditions brought depression like behavior however rodents large phylogenetic distance humans contrast primates closely similar humans making excellent candidate sad model study made first attempt develop sad found short photoperiod conditions lead monkeys display depressive like behavior less spontaneous locomotion less reactive locomotion addition depression related behavioral changes physiological abnormalities occur patients sad weight loss also observed sad monkeys moreover antidepressant treatment reverse depression related symptoms including depressive like behavior less spontaneous locomotion less reactive locomotion weight loss first time study observed sad symptoms provide important platform understanding etiology sad developing novel therapeutic interventions future elsevier rights reserved
helping aggression core topics social psychology far abundant evidence violent media decreases helping increases aggression collected however recent theoretical empirical work demonstrated media also increase prosocial outcomes decrease antisocial outcomes fact exposure media prosocial content increases accessibility prosocial thoughts empathy helping behavior decreases aggression aggression related cognition affect present article reviews research provides overview media exposure helping reduces aggression
paper new approach introduced structural health monitoring offshore platforms procedure uses measured ambient vibration responses corresponding natural frequencies mode shapes structural system since offshore platforms composed heavy supported structures participation first mode dominant direction response structure field excitations moreover ambient vibrations wave loads impacts first modes structure therefore difficult find higher modes pertinent frequencies use accelerometers data introduced innovative method research uses first fundamental frequencies mode shapes structure algorithm employs inverse vibration technique develop simple two three dimensional reference model monitoring health structure show efficiency proposed procedure case study carried models type platform namely finally uncertainty analysis performed due existence noises uncertainties input data collected accelerometers results indicate proposed method ability detect induced damages high level accuracy considering probable sources error elsevier ltd rights reserved
gas diffusion barriers essential building blocks protection sensitive materials devices ambient gases like oxygen moisture work study mechanics processed atomic layer deposition demonstrate wide range grown barrier layers carry intrinsic mechanical tensile stress range mpa application top organic electronic devices derive critical membrane force sigma corresponding layer thickness onset cracking time evidence favorable efficient encapsulation statistically occurring particle defects thus reduce overall membrane force case levels sigma introduce additional layers metals thereby highly robust prepared top organic light emitting diodes crack even heat conditions degrees
tear proximal tibia rare injury lesions mainly affects male adolescents years main causes stress sport activity seems predisposing factor date survey pathogenesis diagnostics treatment strategies literature research level iii studies results affected patients mostly male type iii fractures frequently seen accompanying injuries missed treatment usually consists surgery means open internal recently also minimal results mainly good good approximately reach old level activity almost one third patients develop mostly slight complication acute tear proximal tibia infrequent disease injuries standard procedure open internal fixation lesions within knee particularly expected fractures missed good good result expected correct treatment complications together rare
main aim study conduct preliminary analysis performance two conceptual designs integrate production potable water electricity salt used reverse pressure pro produce potable water electricity salt respectively objective analysis observe relative positions pro integrated process affect five key parameters total dissolved solids potable water rate total energy requirement units net delivered power salt potential simulated integrated design using previously validated mathematical expressions pro found net delivered power higher unit located pro unit sequence also results lower energy requirement producing potable water although rate smaller sequence hand salt potential affected relative positions pro units elsevier rights reserved
introduction irritable bowel syndrome ibs functional bowel disorder characterized chronic recurrent abdominal pain association change bowel habits predominant disorder bowel habits ibs classified three main subtypes constipation predominant ibs ibs diarrhea predominant ibs ibs ibs alternating constipation diarrhea ibs first class oral daily receptor agonist licensed symptomatic treatment moderate severe ibs adults review aims facilitate optimize clinical practices establishing common guidelines monitor patients ibs treated methods group experts functional digestive disorders review efficacy safety develop updated consensus report treatment patients ibs search performed english french spanish language articles pubmed basis articles identified initial document addressing different issues frequently raised general practitioners specialists related prescription efficacy safety document reviewed modified expert panel final text agreed upon validated results based evidence panel addressed following recommendations indicated treatment moderate severe ibs adults recommended patients take continuously patients risk diarrhea given choices concerning deal possible side effect absence potential risks implies treatment maintained long periods time conclusions document seeks lay set recommendations identify key issues useful clinical management ibs patients treated
serve many important functions hiv infected patients including identifying risks developing kidney disease detecting diagnosing kidney disease distinguishing antiretroviral induced kidney injury kidney disease setting antiretroviral therapy clinical course complications ckd preparing patients dialysis transplantation epidemiology kidney disease hiv functions describing natural history disease frequent occurrence high risk communities potential causes risk factors drive ckd hiv black race hypertension diabetes hiv viral replication low cell counts high viral load acquired immune deficiency syndrome defining conditions antiretroviral agents potential prevalence risk factors population determines magnitude problem range low high recent research focuses kidney health hiv important links hiv viral replication glomerular filtration rate even patients normal kidney function now reported review data provides foundation better understanding kidney disease better treatment patients hiv national kidney foundation inc rights reserved
objective replicating training program non verbal communication based theoretical framework interpersonal communication non verbal coding aging aspects perspective active aging checking current relevance content assimilation index days mediate application method descriptive exploratory field study conducted three hospitals direct administration state exclusively unified health system patients training lasted hours divided three meetings applied health professionals results revealed satisfactory satisfactory mediate content assimilation index conclusion program replication proved relevant updated setting hospital services remaining efficient healthcare professionals
fuel consumption viewed fundamental problem operate sea long time without need paper hybridization conventional medium sized reduce fuel consumption considered purpose optimal sizes main components electric motor internal combustion engine battery generator calculated via constrained particle swarm optimization algorithm considers accelerating expectations constraints furthermore new fuzzy controller whose parameters tuned via optimization proposed manage energy flow main components estimate fuel consumption backward forward simulation approach based quasi static maps diesel engine electric motor employed moreover resistance forces calculated typical driving cycle displacement planning modes simulation results reveal hybridization conventional leads reduction fuel consumption without performance constraints
sequential monte carlo smc implementation probability hypothesis density filter suffers low computational efficiency since large number particles often required especially large number targets dense order speed computation algorithmic framework parallel smc filtering based multiple processors proposed algorithm makes full parallelization four steps smc filter computational load approximately equal among parallel processors rendering high parallelization benefit multiple targets dense parallelization theoretically unbiased provides result serial implementation without introducing approximation experiments multi core computers demonstrated parallel implementation gained considerable speedup compared serial implementation algorithm elsevier rights reserved
paper addresses road toll pricing capacity investment problem road network decision making framework goal programming approach used following four major goals considered cost recovery service level environmental equity multiobjective road toll pricing capacity investment problem formulated goal programming model upper level model aims minimize deviations stated goals given priority ranking goals lower level road users route choice equilibrium problem simulated annealing based solution algorithm developed solve proposed model numerical results show priority structure goals significantly affect road toll pricing capacity investment decisions simulated annealing based solution algorithm outperforms sensitivity analysis based solution algorithm terms solution quality proposed methodology provides avenue understanding trade offs among conflicting objectives designing environmentally sustainable transportation system
virtual remote laboratories commonly used engineering education mainly designed using java programming language popular widely used learning management system paper describes development virtual laboratory using easy java simulations software tool integration learning tool virtual laboratory demonstrates easy java simulations used optimal control theory education example known problem solution
rapid growth construction worldwide triggered growing number papers published area past two decades suggesting construction management become emerging area field construction engineering management study aims investigate status trends research conducting structured literature review total relevant articles identified eight peer reviewed journals analyzed based number articles published annually institutional regional contributions citations categorization research interests methodologies analysis results indicated developed countries united kingdom united states australia significant advantages research greater experience research developing countries russia india turkey remains weak lacking results also revealed many theory based findings reported five namely construction site management cost schedule management risk analysis management innovation utilization information technology leadership professional development organization stakeholder management project planning procurement project monitoring control remain promising domains future research particularly developing countries yet develop research tradition incorporating complexity theory institutional theory theoretical foundation develop research strengthened global collaboration future
effects feeding system restricted restriction programs daily weekly base evaluated commercial rabbits housed individually weaning age first three weeks restricted rabbits received intake according two feeding curves daily group weekly week average group restriction period feeding system affected crude protein restricted compared rabbits restriction dry matter ether extract lower previously restricted rabbits compared always fed first period feed restriction reduced daily weight gain feed intake empty body lipid energy contents compared feeding second period previously restricted rabbits showed higher daily weight gain lower feed conversion besides higher empty body lipid energy contents compared rabbits fed whole trial feed restriction reduced mortality tended reduce feed intake feed conversion retention restriction program effects restriction period feeding period rabbits submitted week week restriction exhibited higher weight gain feed intake lower feed conversion compared restricted daily base whole trial rabbits showed higher feed consumption excretion rabbits later age increased final live weight feed conversion percentages fat leg muscle bone ratio empty body lipid energy contents besides body retention excretion conclusion regardless restriction program mild feed restriction first period improved rabbit health status reduced environmental pollution sector without growth performance results traits elsevier rights reserved
work proposed new real time monitoring system distribution transformer communication network obtains voltage current power energy frequency loads connected distribution transformer information collected measurements send server network safe information new real time system build wireless network low energy consumption large transmission distance enough conditions work urban distribution electric network system make possible low cost infrastructure task save electric magnitude possible diagnostic electrical network
ankylosing spondylitis chronic autoimmune disease affecting spine involvement cervical spine occipital joints leads difficulty airway management securing airway conventional report case severe ankylosing spondylitis severe restriction neck movements limited mouth opening conventional impossible patient movement occipital join decided use vision video proved great use publishing services elsevier behalf society
background whole genome amplification techniques enabled analysis unexplored genomic information sequencing single amplified genomes whole genome amplification single bacteria currently challenging contamination often occurs experimental processes thus increase confidence analyses sequenced bioinformatics approaches identify exclude non target sequences required since currently reported approaches utilize sequence information public databases limitations new strains targets interest developed software identify exclude non target sequences independent database results method template control sequences acquired used calculated probability sequence derived contaminants comparing compositions template control sequences based results tests using simulated datasets accuracy method predicting non target sequences higher currently reported techniques subsequently applied tool actual datasets evaluated accuracy predictions conclusions method works independently public sequence information distinguishing non target sequences method effective employed sequences unexplored strains anticipate contribute correct interpretation
background previous studies thoroughly investigated prevalence risk factors completed suicide marked contrast lack better understanding attempted suicide elderly aim study estimate prevalence attempted suicide elderly examine associated factors methods using multi stage cluster sampling approach cross sectional survey elderly house dwelling residents conducted shanghai china results two week prevalence attempted suicide elderly bivariate analysis caregivers depressive anxiety sad fear obsessive compulsive anger symptom lower scores index activities daily living instrumental activities daily living scale significantly associated increased risk attempted suicide elderly multivariate analysis sad fear symptoms significantly independently associated higher risk attempted suicide elderly conclusion two week prevalence attempted suicide elderly relatively high compared lifetime prevalence reported china foreign settings elderly individuals certain mental symptoms targeted suicide prevention provided timely mental health support
rapid development economics country large number high level specialized needed universities expand enrollment scope recruit years undergraduates professional degree study country order improve training quality control engineering full time professional degree series reforms carried northeast petroleum university experience practice represented
paper consider variable coefficient equation variable coefficient potential equation generalized dimensional variable coefficient equation time dependent coefficients shock wave solutions considered models obtained using method form function physical parameters soliton solutions obtained functions dependent coefficients copyright john wiley sons ltd
aim experimental study improve energy absorption capacity tubular metallic structures plastic increasing strength properties materials based novel idea change plastic strength materials predictable loading concept original experimental device represents patent issue developed loading combined compression loading path generated means device tests carried investigate plastic behavior several tubular structures made copper aluminum mild steel effects loading path complexity geometrical parameters structures loading rates notably one plastic flow mechanism mean collapse load energy absorbed carefully analyzed results related copper aluminum metals show plastic strength properties tubes change torsional component rate emphasizes energy absorption improves increasing applied loading complexity however energy absorbed data mild steel tubular structures demonstrate sensitivity quasi static loading path complexity
stem vibration cause drilling often leads non productive time stem vibration analysis performed prevent identify rpm values cause damaging standing waves stem however different models assumptions give different vibration results one simplification commonly done excluding drilling fluids paper investigates effect including drilling hydraulics dynamic pressure stem vibrations model assumes stem acting euler beam discretized using finite element formulation two fluid rheological models power law used determine dynamic pressure drop across stem results show including dynamic pressure stem vibration model causes critical rotational speeds change much rpm expected axial torsional vibrations affected lateral vibration changes significantly ratio diameter stem outside diameter narrow total bit flow area operating high flow rates therefore creating rpm road maps avoid vibrations drilling contribution dynamic pressure included elsevier rights reserved
due increased life expectancy older population growing probability elderly person victim similar crime however little known aging effects accuracy circumstances older adults prone memory errors younger adults study older younger adults memory actions examined recognition test although differences found older adults higher proportion false alarms showed less accurate recognition younger adults addition older adults less able attribute actions occurred correct sources thus source memory deficits contribute explain older adults less accurate recognition finding taken account real life situations elderly person involved
many individuals clinical samples borderline personality disorder bpd experience high levels functional impairment however little known levels functional impairment experienced individuals bpd general community address issue compared overall domain specific educational occupational social recreational functioning sample community based individuals bpd community based individuals without bpd clinically ascertained individuals bpd bpd diagnoses functional outcomes based accepted semi structured interviews community based individuals bpd significantly less likely experience good overall functioning steady consistent employment good relationship compared community based individuals without bpd bpd non bpd risk difference even compared directly non bpd siblings risk difference community based individuals bpd versus without bpd differ significantly domain specific outcomes former group experienced poorer educational occupational performance lower quality relationships parents partners friends however community based individuals bpd significantly likely experience good overall functioning clinically based individuals bpd risk difference latter group likely experience reduced employment status poor quality relationships partners social isolation conclusion community based individuals bpd experienced marked functional impairment especially social domain less likely experience extreme occupational social impairments seen among patients bpd elsevier ltd rights reserved
quality composition biomass used thermal power plants highly variable biomass consists mainly residual forest biomass derived operations wood waste industrial processes particular paper pulp industry quality composition influenced presence moisture fragments latter incorporated collection consequence adherence biomass prior collection variability presents difficulties thermal power plants besides additional operational cost presence large amounts water biomass used fuel result problems related instability combustion accumulation ash rock removed objective paper review main parameters influence quality biomass analysing current state art power generation biomass sector portugal new contribution earlier studies
described situation individuals act groups see individuals thereby facilitating behavior present article analyzes construct theory conceptualization recent theoretical model social identity model effects aim study compare theories highlight advances identify theoretical questions remain suggest future directions study issue recent research conducted promote prosocial behavior prevent social disturbance prevent development prejudice among children furthermore provide feasible way intervene contemporary social issues recent scientific techniques neuroimaging predictive mathematical models improve comprehension construct terms definition prospective effects
approximately one half patients worldwide use complementary alternative integrative methods state evidence therapies used inhomogeneous integrative oncology understood combination conventionally approved medicine conventional mainstream medicine scientifically tested complementary medicine mind body medicine article gives brief survey state evidence fields application mind body medicine integrative oncology efficacy relaxation techniques reduction anxiety nausea enhancement quality life documented level evidence mindfulness based stress reduction shows positive effects primary therapy anxiety stress reduced quality sleep health related quality life hrqol enhanced also good evidence positive effects hrqol breast cancer patients chi beneficial reduction fatigue improvement sleep quality vitality hrqol preoperative reduce doses drugs alleviate pain nausea vomiting fatigue emotional strain many methods mind body medicine good state evidence particularly enhancement hrqol reduction depression better general stress management relaxation training reduction depressive symptoms combat depression mood disturbances fatigue combat fatigue
differences cognitive emotional ratings involving aggressive content texts men women different level analyzed texts scenes violence previously subjected expert procedure identification contents estimated means cognitive questionnaire enables scale emotional informational components texts content according obtained data maximal significant differences texts ratings revealed groups men women high level thus confirming existence sex differences mechanisms determine results discussed context researches
paper describes structure manufacturing engineering data integrated process manufacturing resources planning recommendations requirements data structures integration effective manufacturing engineering presented examples data structure data base original integrated computer aided manufacturing engineering system provided
classification numeric estimation two common types data mining goal classification predict discrete type output values whereas estimation aimed finding continuous type output values predictive data mining generally achieved using one specific statistical machine learning technique construct prediction model related studies shown prediction performance kind single flat model improved utilization hierarchical structures hierarchical estimation approaches usually combination multiple estimation models proposed solving specific domain problems however literature generic hierarchical approach estimation hybrid based solution combines classification estimation techniques therefore introduce generic hierarchical architecture namely hierarchical classification regression suitable various estimation problems simply speaking first level involves pre processing given training set classifying classes leading subsets three approaches used perform task study hard classification fuzzy means genetic algorithms training data containing associated class label used train support vector machine svm classifier classification next second level regression estimation models trained based corresponding subsets final prediction experiments based different datasets show hierarchical prediction models developed architecture significantly outperform three known single prediction models linear regression multilayer neural networks support vector regression terms mean absolute percentage error root mean squared error rmse rates addition found using based data pre processing approach classify training set subsets best threshold class svm outperforms three baseline hierarchical regression models
objective belongs family cysteine rich secreted mainly produced monocytes macrophages humans recently high concentrations shown induce vascular endothelial dysfunction vascular smooth muscle cell proliferation examined secreted macrophages locally affected vascular cell function human methods results immunohistochemical staining human vessels showed aortic exhibited positive staining areas along macrophage infiltration normal arteries veins localization marker macrophages observed double staining mrna expressed much higher cultured macrophages human vascular smooth muscle cells human umbilical venous endothelial cells suggested macrophages within vessels determine effects atherosclerosis human incubated similar activator inhibitor release assayed elisa mrna levels analyzed northern blotting increased significantly treatment factors migratory activity measured wound assay also increased significantly times summary macrophages infiltrating atherosclerotic affects endothelial function migration conclusions secreted macrophages contribute virtue effects vascular endothelial cells smooth muscle cells humans european society cardiology published elsevier rights reserved
study adds body research examining links two components cognitive self regulation inhibitory control verbal working memory social functioning social integration social problem solving prosocial skills focuses childrens sex moderator association cognitive self regulation social functioning participants french followed months months grade using hierarchical regression analyses three major findings revealed inhibitory control better predictor verbal working memory prosocial skills assessed peers using technique teachers using questionnaires controlling sex mothers education verbal non verbal prosocial skills assessed teachers contributed explaining prosocial skills peer acceptance assessed grade cognitive self regulation sex moderate relationship cognitive self regulation social functioning results suggest developing strong cognitive self regulation especially inhibitory control prosocial skills young children france beneficial social development
hereditary angioedema due inhibitor deficiency inh hae rare disorder characterized intermittent unpredictable episodes swelling cause disability pain case laryngeal swelling risk death historical factors including intermittent nature disorder lack awareness ultra rare condition amongst medical personnel lack specialist centers limited treatment options contributed diagnosis treatment condition incorrect treatment attacks common even medical help sought lead reduced health seeking behavior alternative coping strategies sometimes even denial many families minority hae affected patients become serial emergency room chronic pain ongoing requirement based strategies incurred physical also psychological economic consequences last years new effective acute therapies made available also provided short term long term prophylaxis options together better understanding older prophylactic drugs improved awareness hae amongst general public family members physicians reduced long delay diagnosis increased number patients receiving effective date therapies improve physical impact disorder data impact treatment psychological outcomes scarce limited information available suggests access specialist advice treatment leads psychological physical improvement hae also profound effects individual family economic output directly via school work indirectly via lost opportunities economic improvements associated better treatments offset high cost new acute treatments resulting difficult economic calculations worldwide cost considerations present potentially barriers treatment many patients depending healthcare system individual country
inflammatory bowel diseases chronic conditions unknown etiology showing growing incidence prevalence several countries including italy although etiology crohns disease ulcerative colitis unknown due current knowledge regarding pathogenesis effective treatment strategies developed several guidelines available regarding efficacy safety available drug treatments inflammatory bowel diseases nevertheless national guidelines provide additional information adapted local feasibility costs legal issues related use drugs observations prompted italian group study inflammatory bowel disease ibd establish italian guidelines safety currently available treatments crohns disease ulcerative colitis guidelines discuss use systemic low bioavailability corticosteroids antibiotics methotrexate tnf alpha antagonists combination therapies guidelines based current knowledge derived evidence based medicine coupled clinical experience national working group published elsevier ltd rights reserved
often surgically due male infertility however recently linked low serum testosterone paper serves review current literature regarding subsequent repair serum testosterone twenty eight human studies identified fifteen showing improved serum testosterone repair majority studies demonstrated improvement preoperative testosterone levels low normal additionally multiple designed studies control groups undergoing surgical repair demonstrated significant difference groups improvement less observed studies normal preoperative serum testosterone majority patients studied presenting infertility remains determined findings reproduced men without infertility findings suggest repair improve serum testosterone men low levels preoperatively appropriately men remains seen whether repair help prevent development low testosterone future patients risk developing low testosterone due
objective article consider discuss existing research theory concerning problem behaviors offending applicable populations children adolescents primary databases used search literature medline google scholar used additional internet search engine primary focus literature published since earlier literature considered important also included qualitative quantitative studies suggest consumption violent media affects aggressive behaviors supports existence effect within offending populations existing literature suggests processes desensitization observational learning priming alteration scripts involved behaviors mediated individual environmental media factors literature concerning largely overlooked possibility effect given young age often antisocial nature individual environmental problems associated population particularly vulnerable effect need consideration potential role media behaviors care taken way media reports events
consensus cardiac stem cell biology field human embryonic stem cell derived cardiomyocytes cms immature resemble human adult cardiomyocytes either one striking difference cms mature adult cardiomyocytes morphology cms grown vitro shape clear organization conversely adult cardiomyocytes rod shaped average length width aspect ratio display highly organized internal cytoskeletal structure combining multiple cues substrate stiffness features possible create physiologically relevant model better architecture native human heart aid regenerative medicine therapies disease modeling drug testing developmental studies prior work lab used printing glass control cell shape improve maturation cms since new work focused methods compliant substrates using printing alcohol film advantages disadvantages methods discussed relationship maturation
antidepressant rapid onset action one recent drugs antidepressant category antidepressant actions attributed sleep promoting actions mediated receptors present nucleus effects blockade receptors blockade receptors causes release dopamine cortical dopaminergic pathways combined actions receptors facilitate altered circadian rhythms abnormal sleep patterns appeared effective treating major depression moreover evidence exists points possible efficacy drug treatment bipolar depression anxiety disorders alcohol dependence etc thus aim narrative review elucidate current evidences role disorders major depression
hepatitis virus hcv major cause chronic liver disease worldwide due asymptomatic nature infection many acute cases hcv infection left screening individuals risk important public health priority new medications offer sustained response rates fewer adverse reactions shorter durations therapy article reviews new treatment guidelines evaluation management patients hcv infection
paper presents new optimization algorithm based human intelligent world international association football competition senior mens national teams one significant among humans people teams try hard overcome others competition one best position rather others paper introduces new technique optimization functions based world main difficulty optimization problems type interpreted specific manner world optimization algorithm number parameters solve type problems due defined parameters analyzing system performance applied benchmark functions also applied optimal control problem practical case study find optimal parameters pid controller considering nominal operating points changes system main objective proposed system minimize steady state error also improve transient response system optimal pid controller optimal values pid controller achieved algorithm compared particle swarm optimization competitive algorithm different situations finally illustrating system capability disturbance applied generator disturbance results compared algorithms simulation results show excellence algorithm performance nature base competitive algorithms
structurally simple water soluble fluorescent probe responsive acidic conveniently synthesized via one step condensation reaction stable highly sensitive sensor probe displays approximately fold fluorescence enhancement range structure probe changes weak fluorescent ring open strong fluorescent decreasing synthesized fluorescent probe applied detection changes vitro vivo gastric cancer cells satisfactory results
india production electricity thermal power plants accounts total electricity generated thermal power plants produce million per year coal ash waste materials disposal ash poses threat environment requires allocation vast land area storing land ash generated thermal power plants falls two categories namely fly ash pond ash one ways minimize harmful effects due unsafe disposal ash environment utilize ash construction industry making cement manufacture etc moreover conventional making natural soil resource one essential requirements green building use environmentally friendly building materials reuse industrial waste products like fly ash pond ash fly ash pond ash used optimally replacing clay manufacturing industry waste material treated material also reduce pressure soil besides energy saving methodologies green building involves application technologies using materials without affecting natural resources investigation attempt made devise ways optimal use pond ash manufacturing coal ash article presents experimental results coal ash made pond ash fly ash stone dust fundamental strength durability tests conducted evaluate basic properties energy dispersive ray diffraction study scanning electron microscope sem study carried elemental analysis analyze chemical composition materials
therapeutic relationship particular importance working patients antisocial personality disorder despite paucity literature exploring student nurses perceptions developing therapeutic relationship patients hence qualitative study explored perceptions second year mental health nursing students developing therapeutic relationship patient group student nurses university northwest england participated two focus groups compare perceptions group student nurses experience secure settings forensic hospital four key themes emerged diagnosis safety engagement finally environmental influences groups looking beyond diagnosis seeing person student nurses cited staff clinical placement areas influential terms development perceptions patients antisocial personality disorder relate
play important roles various biological processes cell adhesion signal transduction promote anti inflammatory activity previously revealed glycol split heparin amine conjugates form self assembled nanoparticles suppress production pro inflammatory cytokines tumor necrosis factor tnf alpha interleukin beta lipopolysaccharide lps stimulated macrophages much strongly native control release considering anti inflammatory activity present study initiated examine whether conjugation generally effective activity augmentation lps stimulated macrophages newly synthesized conjugates sulfate acid low molecular weight heparin investigated effect position degree molecular weight anti inflammatory activity conjugates formed self assembled nanoparticles aqueous solution value suppression tnf alpha production macrophages smallest derivative followed degree appeared important determining anti inflammatory activity correspond previous results using derivatives site selectively comparison derivatives revealed smaller heparin greater anti inflammatory activity
aid theoretical calculations series molecularly polymers designed prepared recognition via precipitation polymerization using solvent basis long range correction method simulated bonding sites bonding situations binding energies molar ratios mechanisms interaction functional monomers among acid acid confirmed best functional monomer strongest interaction maximum number hydrogen bonds lowest binding energy occurs optimal molar ratios functional monomers used respectively additionally confirmed best cross linker among ethylene glycol due facts interaction highest binding energy occurs strongest interaction lowest binding energy occurs depending results theoretical calculations series prepared among ones prepared using template functional monomer cross linker respectively exhibited highest adsorption capacity apparent maximum absorption quantity
paper explicit model predictive control mpc two stage diesel engine presented mpc provides superior performance conventional map based pid boost pressure control easily adapted multivariable control relatively easy tune control oriented multiple input multiple output model diesel engine derived using system identification methods mpc control design based linear model validation controller carried using high fidelity nonlinear engine model using high fidelity simulation model provides opportunity fine tune controller real time testing experimental real time tests demonstrate superior control performance wider range compared performance obtained using conventional control
maltreatment related persistent stress response marker hypothalamic pituitary adrenal axis activation however studies examined levels children exposed aim study compare serum levels children reporting child abuse neglect children history methodsthis study included children positive history moderate severe reported parent clinical interview children history comparison group considered moderate severe based child reported frequency exposed events related sexual abuse physical abuse emotional abuse emotional neglect physical neglect child psychopathology symptoms assessed using child behavior checklist measured serum concentration using enzyme linked immunosorbent assay exposed exhibited higher levels serum compared children without controlling sex age psychiatric morbidity total score including internalizing externalizing symptoms higher children found correlation scores internalizing symptoms externalizing symptoms conclusion associated serum levels independently age sex symptom severity promising new biomarker children history abuse neglect
systematic way integrated circuit signal flow graph sfg equivalence presented sfg transfer functions loop gains input output readily computed analysis valid amplifiers computation three stage amplifier nested compensation presented illustrate robustness method two sfg relating stability networks also derived
performance rainwater harvesting rwh system mediterranean climate assessed stochastic model quantifying necessary storage function rainfall frequency depth roof area residents number specific water use toilet flushing required efficiency developed two performance indicators calculated water saving efficiency proportion water used supplied rwh system rainwater use efficiency proportion rainwater actually used maximum storage capacity decreased increasing number residents given roof area increasing roof area constant number residents variable storage volume increased increasing storage capacity reached maximum increase residents number decrease roof area model enables determine specific storage volumes determine desired calculate necessary storage
phase dynamics phase noise coupled phase locked loops independent oscillators analyzed phase noise coupled independent oscillators analyzed using signal flow graph gain rules near carrier phase noise elements array reduced single independent without coupling element return free running phase noise far carrier frequency provided coupling network reciprocal feedback loop gain elements large phase detector amplifier noise neglected phase dynamics noise improvement coupled arrays verified using two coupled independent oscillators operating band
large scale parallel computing system becoming failure prone due increasing number computational nodes results serious reliability problems parallel computing ensure successfully running parallel tasks meta tasks tasks necessary perform reliability analysis scheduling parallel tasks meta tasks key factors discussed affect impede successful execution single task reliability formula meta tasks presented tasks hardware failures software failures network link failures execution order taken account calculate reliability also reliability network communication two reliability algorithms tasks designed finally experiments conducted experimental results show reliability analysis methods effective comprehensive
purpose utilities major source delay indian infrastructure projects delay particularly critical road bridge construction projects purpose paper identify various factors also factors influence delays utilities design methodology approach case studies conducted road bridge projects india varying levels complexity size factors causing delays identified using computer aided qualitative analysis methodology cognitive mapping technique used map factors identify critical delay factors findings factors affecting delays identified across two groups namely technical organizational factors study offers insights kinds interactions factors lead delays project critical factors causing delays identified slow response utility agencies difficulty identification underground utilities lack information underground utilities conflict agencies research limitations implications limitations study interview respondents distributed among type organizations induced bias responses impact utility delays overall project delay detailed practical implications factors potential help officials highway department contractors utility agencies others understand various interactions linkages factors contributes delays utility recommendations provided practical use reduce impact delays originality value utility received little attention extant literature paper seeks contribute knowledge area identifying linkages factors critical factors utility delays india
existing programming tools writing high performance simulation code labor intensive requires portability alternative prototype simulations high level language like matlab thereby performance matlab programming model naturally describes behavior entire physical system using language linear algebra however simulations also manipulate individual geometric elements best represented using linked data structures like meshes translating linked data structures linear algebra comes significant cost machine high performance implementations avoid cost computation terms linked index data structures leaving code complicated monolithic often increasing size order magnitude article present new language physical simulations view system linked data structure form set global vectors matrices depending convenient given time provides novel assembly construct makes conceptually easy computationally efficient move two using information provided assembly construct generates efficient place computation graph demonstrate easy use program typically shorter matlab program high performance program running sequentially cpu performs hand optimized simulations portable programs compiled gpus change program delivering optimized cpu code
paper present concurrent systems class parallel programming parallel distributed computing concepts taught years despite several rounds changes hardware class maintains goals allowing students learn parallel computer organizations studying parallel algorithms writing code able run parallel distributed platforms discuss benefits class reveal key elements developing class receiving funding replace hardware also share activities attracting students interested related topics
current medical practice long term chronic respiratory diseases treatment lacks convenient method empowering patients caregivers continuously quantitatively track intensity respiratory symptoms asthmatic occurring respiratory sounds mobile personalized asthma monitoring system comprising wearable energy constrained acoustic sensor smartphone paper address energy burden acquisition streaming acoustic respiratory signal applying concept compressed sensing first analyse adherence normal pathologic respiratory sounds frequency representations discrete fourier transform discrete cosine transform sparse signal model given pseudo random non uniform implemented microcontroller review accuracy execution time different algorithms suitable real time respiratory spectrum recovery smartphone working respiratory spectrum acquisition prototype demonstrated evaluated prototype enables real time reconstruction spectra dominated approximately eight frequency components accuracy android smartphone using orthogonal matching pursuit algorithm signal samples respect rate acquired sensor
efficient routing quality service qos guarantees safety traffic communication plays vital role success vehicle hoc networks due connection less nature network establishing stable route connected nodes extremely important challenging paper proposes new algorithm multi constrained qos routing network adopting clustering approach algorithm design qos metrics used addition stability metrics finding establishing stable route destination achieved calculating corresponding qos provision values selecting optimal reliable stable route network simulator used experiment proposed scheme results show significant improvement proposed approach terms broken links routing overhead end end delay
current terminology goals general competency framework systematically utilized education residents regardless specialty almost quite foreign trained example clinical professional expectations physicians training placed onto developmental framework expectations required training expanded include leadership team participation skills use information technology systems based knowledge including respect resources cost care patient safety quality improvement population health sensitivity diversity individual populations patients physician training council graduate medical education remain social contract medicine public focus psychiatric practice article provides general background overview major process educational goals graduate medical education briefly highlights possibilities future
recent decades main demographic historical research assessed importance bio demographic components human reproduction diffusion birth control contraceptive techniques according dominant view fertility decline marital fertility mainly regulated biological physiological factors socio economic factors played limited indirect role order demonstrate importance non biological components present study focuses six pre transitional communities situated different geographic areas italy work aims demonstrate fertility levels significantly affected social economic factors even natural fertility populations diffusion contraceptives micro level data collected several historical sources discrete time event history models applied female reproductive careers order estimate effects socio economic status household structure price fluctuations marital fertility controlling several bio demographic factors despite clear differences geographic localization environment marital reproductive behavior appeared significantly constantly affected socio economic status household composition price levels investigated communities
satellites play role human daily life satellites sent space time foreign space powers competing develop satellite stealth technology safety factors survival ability satellite ignored analysis space surveillance system high orbit satellite strong optical detection capability optical visibility spatial objects optical typical satellite body finally pointed development satellite optical stealth technology imperative
human gene reported mediate risk seasonal affective disorder sad hypothesized caused decreased input winter light levels fall threshold resulting differences circadian phase sleep however unclear increases risk sad causing differences sleep circadian phase differences symptoms mood disorder determine sequence variations associated differences sleep wake behavior among suffering mood disorder authors tested associations gene polymorphisms self reported sleep timing sleep onset wake time community sample non hispanic caucasian participants age history psychological neurological sleep disorders authors also tested effect variations differences preferred sleep activity timing reflect differences circadian phase sleep homeostasis day assessment measured included analyses dna samples genotyped gene polymorphisms using fluorescence polarization genotype interacted predict self reported sleep onset interaction specifically sleep onset among genotype later day individuals assessed longer days earlier day shorter days whereas individuals genotype groups show interaction effect genotype also interacted analogous way predict self reported interaction results suggest genotype interacts predispose individuals vary sleep onset function whereas genotypes seem effects vary better understanding confers heightened improve understanding broad range behavioral responses light circadian sleep mood etiology disorders seasonal patterns recurrence exacerbation author correspondence
nearest neighbor method widely used applications data mining machine learning due simple implementation distinguished performance however setting test data value previous methods proven make methods real applications article proposes learn correlation matrix reconstruct test data points training data assign different values different test data points referred correlation matrix short classification specifically least squares loss function employed minimize reconstruction error reconstruct test data point training data points graph advocated preserve local structure data reconstruction process moreover norm norm applied learn different values different test data result low sparsity remove redundant noisy feature reconstruction process respectively besides classification tasks methods including proposed method utilized regression missing data conducted sets experiments illustrating efficiency experimental results showed proposed method accurate efficient existing methods data mining applications classification regression missing data
background cytotoxic lymphocyte antigen plays pivotal role immune homeostasis dysregulated expression leads many autoimmune diseases including rheumatoid arthritis systemic lupus erythematosus type diabetes controversial association snp autoimmune diseases therefore meta analysis performed assess link autoimmune disease risk materials methods retrieved available studies pubmed embase february performed meta analyses included populations ethnicity results evaluating data patients healthy controls included caucasian asian found strongly associated autoimmune disease incidence comparison confidence interval comparison allelic model allele allele dominant model recessive model odds ratio models suggested significant association autoimmune diseases conclusion present study indicates associated susceptibility autoimmune disease hence utilized diagnostic biomarker asian caucasian populations
article visits relationship teacher beliefs teaching behaviours analyses factors influencing translation teacher beliefs teaching behaviours using case developing generic skills university students interviews teachers skills subjects teachers subjects business administration programs six different universities shown indirect relationship teacher beliefs teaching behaviours analysis showed institutional leadership teachers personal motivation strongly influence translation beliefs actual teaching behaviours elsevier ltd rights reserved
background analysis residual gene expression nuclear factor activated cell regulated genes developed pharmacodynamic biomarker monitor therapy inhibitors availability commercial primer sets search established assay protocol makes biomarker promising candidate used clinically different laboratories however implementation method routine practice requires analytical robustness comparable results across laboratories therefore protocol originally established institute immunology verified institute laboratory medicine comparison study conducted laboratories methods analytical verification whole blood samples healthy individuals incubated vitro linearity limit quantification sample stability investigated comparison samples patients therapy analyzed within hours results decreased expression regulated genes vitro dose dependently within assay coefficient variations limit quantification cdna copies interleukin interferon macrophage colony stimulating factor genes samples stable hours comparison using patient samples correlated showed inconsistent bias depending magnitude residual gene expression conclusions assay set satisfactory analytical performance routine molecular biological laboratory shows comparable results laboratories reproducibility regulated gene expression assay across laboratories facilitate implementation assay pharmacodynamic routine monitoring inhibitors different centers
objective aim study investigate predictive factors need persistent antimuscarinic therapy treatment discontinuation antimuscarinic therapy women overactive bladder syndrome oab methods consecutive oab women enrolled prospective cohort study treated weeks university hospital factors affecting analyzed cox regression analysis results total women enrolled women underwent week treatment dropout rate median follow period weeks interquartile range twenty seven women median free interval weeks nocturia episodes hazard ratio suboptimal response hazard ratio strong desire volume hazard ratio independent predictors cox backward stepwise regression analysis areas receiver operating characteristic curves nocturia episodes suboptimal response strong desire volume predict respectively addition normalized urinary nerve growth factor level significant hazard ratio predicting furthermore normalized urodynamic findings correlate suboptimal response changes overactive bladder symptom score urinary nerve growth factor level conclusions frequent nocturia episodes suboptimal response small bladder capacity predict treatment findings serve initial guide consultation regarding treatment oab
background exposure media violence detrimental effects psychological adjustment associated aggression related attitudes behaviors result many media literacy programs implemented tackle major public health issue however little evidence effectiveness evaluating design effectiveness particularly regarding targeting process prevent adverse effects improve evaluation evidence based media literacy programs objectives present research examined whether different relational lifestyles explain different effects intervention program research design based relational lifestyles theory authors designed randomized controlled trial applied analysis variance treatment experimental control lifestyle classes emerged data using latent class analysis communicative autonomous meta subjects seven hundred thirty five italian students distributed classes participated research females measures participants completed lifestyle questionnaire attitudes behavioral intentions dependent measures results results indicated program effective changing adolescents attitudes toward violence however behavioral intentions toward consumption violent video games moderated lifestyles communicative relational lifestyles showed fewer intentions consume violent video games effect found among participants problematic lifestyles conclusion adolescents lifestyles played important role influencing effectiveness intervention aimed changing behavioral intentions toward consumption violent video games reason audience lifestyle segmentation analysis considered essential technique designing evaluating improving media literacy programs
coupling iso yield urea gas phase important vacuum deposition processes functional organic thin films molecular layer deposition chemical vapor deposition study kinetics thermodynamics reactions containing moieties calculated using double hybrid density functional theory find systematic structure reactivity relationships activation energy proton transfer step correlated acid coupling reaction depends whether functionality analysis transition states revealed location transition state affected electronic spectra product obtained help future experimental investigations
objective unusual unexpected effect treatment background ankylosing spondylitis chronic inflammatory disease predominantly affects axial skeleton ability anti tnf alpha agents reduce disease activity patients axial spondyloarthritis including demonstrated multiple randomized trials several meta analyses reports efficacy rituximab treatment described good results report patient failed anti tnf therapy showed good clinical improvement rituximab therapy case report year old male patient diagnosed showed poor response non steroidal anti inflammatory drugs nsaids infliximab initiated marked improvement per bath ankylosing spondylitis disease activity index basdai due disease patient switched etanercept subsequently acquired thyroid cancer etanercept discontinued underwent total followed therapy ongoing active disease nsaids lack response basdai rituximab started resulted significant improvement basdai conclusions rituximab potential target therapy patients start lose response tnf inhibitors develop solid malignancies placebo controlled studies required
explore favorable structural system cable stayed bridges ultra main span based fully self anchored cable stayed bridge main span partially earth anchored cable stayed bridge scheme main span designed numerical investigation dynamic characteristics aerodynamic stability two bridge schemes conducted results compared suspension bridge similar main span considering aspect wind stability feasibility using partially earth anchored cable stayed bridge super long span bridges ultra main span discussed moreover effects structural design parameters including length earth anchored girder number auxiliary side span height width girder tower height etc dynamic characteristics aerodynamic stability partially earth anchored cable stayed bridge analyzed reasonable values proposed results show compared fully self anchored cable stayed bridge suspension bridge similar main span partially earth anchored cable stayed bridge greater structural stiffness better aerodynamic stability consequently becomes favorable structural system super long span bridges ultra main span partially earth anchored cable stayed bridge achieve greater stiffness better wind stability cases increasing earth anchored girder length increasing height width girder setting several auxiliary side span increasing tower height
moments useful image descriptors belong family orthogonal rotation invariant moments due many attractive characteristics used many pattern recognition image processing computer vision applications however suffer high computation complexity use many practical problems computed process image data kernel functions past various attempts made efficient computation considerable success achieved using recursive relations way symmetry anti symmetry function paper propose new computational flow model image data kernel functions proposed model also takes advantage way symmetry anti symmetry property kernel function builds process reduces number number refer table text location circular disk moments computed detailed experimental results show speed computation increases factor varying depending upon order moments multiple images compared existing fast algorithms available literature computed pixel image overlapping blocks improvement computation time varies elsevier gmbh rights reserved
chronic pain global problem reached epidemic proportions estimated adults suffer pain another diagnosed chronic pain year despite high prevalence chronic pain estimated billion people worldwide much remains understood underlying causes condition urgent requirement better pain therapies discovery novel targets development better rely preclinical animal models however major challenges translating discoveries made animal models realized pain therapies humans review discusses common animal models used clinical chronic pain conditions inflammatory visceral pain methods assessing sensory affective components pain animals also discuss advantages limitations modeling chronic pain animals highlighting strategies improving predictive validity preclinical pain studies wiley periodicals inc
background autistic individuals commonly show special interests areas obsessive interest specific category present study investigated impact interests attention aspect autistic cognition often reported altered individuals interest expertise shown result automatic attentional priority related items examine whether change salience also seen autism methods adolescents young adults without autism performed personalized selective attention task assessing level attentional priority afforded images related participants specific interests addition participants performed similar task generic images order isolate effects interest expertise autistic non autistic individuals recruited study held strong interest differences attention solely attributed differing prevalence interests two groups tasks participants asked perform central target detection task ignoring irrelevant related unrelated interests level interference various task conditions taken indication attentional priority results individuals showed predicted attentional priority interest images generic items reflecting impact interest expertise contrary predictions autistic individuals show priority processing interest related stimuli task demands low attention images unrelated interests equivalent two groups conclusions results suggest despite autistic individuals holding intense interest particular class stimuli reduced impact prior experience expertise attentional processing implications absence automatic priority discussed terms behaviors associated condition
paper adapt robust quantization index modulation originally proposed images protection relational databases order bit modulate relative angular position circular histogram center mass one numerical attribute experimentally verify suitability scheme terms distortion robustness complexity within framework one medical database one half million inpatient hospital stay records solution robust common database attacks deletion insertion attribute value modifications embedded message error free retrieved even suppression addition database making suitable database copyright protection owner identification tracing
natural antioxidant used prepare films cold casting method concentration component optimised applying box experimental design goal radical scavenging capacity film forming suspensions measured free radical assay results showed synergistic effect antioxidant capacity radical scavenging antimicrobial activity escherichia coli release food faster films containing containing kinetic data release films fitted model possible molecular interactions observed ftir spectrum composite films within range strong interference caused hydrogen bonding water residues observed owing simultaneous antioxidant antimicrobial activities displayed films potential application preservation fresh food fish meat elsevier ltd rights reserved
software defined networking emerging paradigm breaks vertical integration traditional networks provide flexibility program network logical centralized network control capability adapt network parameters fly based operating environment decoupled structure serves solution managing network flexibility ease centralized cost effective architecture provides network visibility helps achieve efficient resource utilization high performance due increasingly pervasive existence smart programmable devices network provides security energy efficiency network virtualization enhancing overall network performance present various security threats resolved new threats arise result implementation recent security attacks countermeasures also summarized form tables also provide survey different strategies implemented achieve energy efficiency network security implementation effort anticipate future evolution new paradigm discuss main ongoing research efforts challenges research trends area paper readers thorough understanding architecture different security attacks countermeasures energy efficiency
cultural values regarding gender roles encourage gender discrimination practice sex selection increasing political work force participation women challenges norms exploiting implementation indian law required one third local political reserved women investigate impact female leadership sex selection rural india find increase survival higher birth order girls political local level reserved women argue likely underlying mechanism change beliefs due exposure female leaders
paper presents home area network han based domestic load energy consumption monitoring prototype device part advanced system device placed individual loads configured measure several loads whole wireless communication infrastructure supported ieee run stack data acquisition concerning load energy transit processed real time main electrical parameters transmitted link wireless terminal unit works data human machine interface voltage current sensing implemented using effect principle based transducers code developed two bit microcontroller units main features design options thoroughly discussed main contribution paper proposed system measures reactive energy component hilbert transform low cost measuring device systems
importance leadership improving educational outcomes schools widely promoted however nature leadership practices context received less attention educational leadership literature article present case study specific leadership practices developed one school site serving learning needs students complex diverse low socio economic community south east australia rather focusing person role leader various leadership qualities traits examine nature leadership practices across variety roles developed within school help make sense educational leadership practices draw upon recent neo practice theory reveal specific actions dialogue relationships constituted leadership practice evident formal leadership practices responsive context history particular school site formal informal leadership practices involved establishing leadership group within school address students needs informal leadership practices focused teacher learning student learning approach simply reinforce notions constitutes educational leadership sheds new light upon nature leading practices
composite winding process pressure fluctuation affect density homogeneity products make interfacial strength fiber volume fraction order improve guiding precision stability winding pressure bearing guide replaced rolling guide designing pressure guiding mechanism parametric model guiding mechanism established based dynamics experiment joint surfaces analyzing modal harmonic response corresponding measures improvement proposed experimental results show designed guiding mechanism based rolling guide high precision perfect stability additionally error installation error cause winding pressure gas nonlinear flow dead zone cylinder friction measurement noise nonlinear disturbances significant impact pneumatic pressure control system considering adaptive fuzzy proportional integral derivative pid controller based grey prediction proposed predicting output pressure trend pressure signal reflected accurately provides reliable basis decision making fuzzy pid controller simultaneously two separate fuzzy inference systems employed adjust step length predictive control scale factor step self tuning algorithm simulation experimental results show fuzzy pid controller based grey prediction shorter settling time smaller overshoot error stronger robustness interference immunity designed guiding mechanism control algorithm effectively improved precision stability pressure control system composite materials winding formation
skin self care part human life birth death today many different skin care practices preferences routines exist parallel addition preventive therapeutic skin care delivered nursing healthcare formal informal caregivers aim contribution critical discussion skin care context professional nursing practice explicit skin assessment using accurate diagnostic statements needed clinical decision making special attention paid high risk skin areas either dry safety perspective protection maintenance skin integrity highest priority skin removal unwanted substances skin surface despite efficacy water inevitably always result destruction skin barrier thousands products available protect restore skin properties dependent upon formulation concentration ingredients products intended left contact skin exhibit several actions skin interfering skin biology unwanted side effects include hyper hydration lipid stratum dysfunctional barrier increased susceptibility allergies increases skin surface skin barrier impaired appropriate interventions apply products sufficient quantity treat dry skin protect skin exposure provided key statement contribution every skin care activity matters every time something placed skin functional structural response response either desired undesired beneficial harmful choice skin care interventions nursing healthcare practice based accurate assessment skin concomitant health conditions clearly defined outcome standardized skin care skin care product language needed researchers planning conducting clinical trials reviewers systematic reviews evidence base nurses healthcare workers deliver evidence based safe skin care published elsevier ltd
authors proposed new method automatically mesh computed tomography based human airway geometry computational fluid dynamics cfd based simulations pulmonary gas flow delivery traditional methods construct mesh realistic geometry time consuming done manually using image processing mesh generating programs furthermore thoracic image data sets include upper airway structures overcome issues proposed method consists cfd grid size distribution automatic algorithm addition laryngeal model along turbulent velocity inflow boundary condition attached proximal end method based previously developed geometric model irregular cross sections fitted segmented airway surfaces fitted surface model new method utilizes anatomical information obtained one dimensional tree skeleton connectivity branch diameters efficiently generate optimal cfd mesh automatically impose boundary conditions systematically reduce simulation results deposition predicted proposed method agreed prediction traditional based model laryngeal model generated realistic level turbulence furthermore computational time reduced factor two without losing accuracy using proposed grid size distribution new method suited branch branch analyses gas flow distribution multiple subjects due embedded anatomical information elsevier ltd rights reserved
consider problem sampling points collection smooth curves plane family proximity based reconstruction algorithms curves reconstruction requires dense sampling local features parts curve close euclidean distance far apart show epsilon sampling sufficient proposed variant improving upon state art requirement epsilon sampling thus reconstruct curves many fewer samples also present new sampling scheme reduces required density even epsilon sampling achieve better controlling spacing consecutive points novel sampling condition based reach minimum local feature size along intervals samples mathematically closer reconstruction density requirements particularly near sharp features prove lower upper bounds reach sampling density terms epsilon sampling demonstrate typically reduce required number samples reconstruction half
shown reflection type dispersive delay structure units inherently superior transmission type units terms analog signal processing resolution since provide higher group delay swing however units suffer drawback requiring separate input output signals order solve issue paper presents unit formed combining two identical units hybrid proposed unit experimentally demonstrated two unit provide resolution enhancement one order magnitude compared purely counterpart
paper algorithm designed games strong background light six uniformly distributed edge game machine screen located four middle top bottom edges three odd frames three even frames simulator one camera used obtain image applying inter frame difference even odd frames resulting images six led six bright spots obtain coordinates rapidly proposed method based area bright spots camera based model four equations found using relationship image coordinate system world coordinate system perspective transformation center point image supposed virtual point perspective transformation matrix applied coordinate center point obtain virtual points coordinate world coordinate system game player shoots target two meters away using method discussed paper calculated coordinate error less ten obtain coordinate results per second meets requirement real time system proves algorithm reliable effective
brain network comprising medial prefrontal cortex amygdala plays important roles developmentally regulated cognitive emotional processes however little known maturation amygdala circuitry conducted anatomical tracing projections synaptic connections neurons amygdala neonatal adult developmental stages mice results indicate projections exhibit delayed emergence relative pathways establish synaptic transmission excitatory inhibitory neurons late infancy events massive increase overall synaptic drive subsequent adolescence circuits modified excitatory synaptic strengthening transient surge feedforward inhibition latter correlated increased spontaneous inhibitory currents excitatory neurons suggesting maturation period transmission findings establish time course onset refinement transmission point potential sensitive periods development critical network
location verification witnessed significant attention communication due growth number location based intelligent transport system applications traditional cryptography based techniques suggested secure verify location vehicles traditional techniques increase protocol complexity computational overhead due hoc nature network environments context study proposes two layered location information verification security lives technique based belief model layer based verification performed using concepts virtual roads received signal strength layer based verification performed specifically belief presence vehicle belief presence vehicle vehicles combined collective belief location claim vehicle performance lives evaluated road based map based network environments single mixed multiple adversary vehicles considered network environments comparative performance evaluations benefits lives compared verification inference position using anonymous without using lives
object oriented modeling become integral part design process construction due advances computer software despite advances remains tendency computer aided design cad used medium assist creation modification analysis optimization electrical instrumentation systems within heavy industrial engineering projects paper retrospective systems information model systems utility facility constructed engineering procurement construction contractor purpose construct ability assessment prior construction presented discussed cad cable schedule produced provided organization undertake assessment errors information redundancy identified quantified model used examine proposal construction discrepancies identified suggested differences arose due prevailing errors potential use construction quality assurance control examined suggested used ensure development built model provide realistic representation constructed asset integrity operations maintenance elsevier rights reserved
automated industries require high quality power supply better performance therefore power generating units play crucial role work multi area power system incorporates six area thermal power systems different steam configuration investigated automatic generation control investigated system included non thermal power system area area single thermal power system area double thermal power system areas interconnected tie line proportional integral derivative pid controller proposed secondary controller provide necessary control signal sudden load demand achieve optimal pid controller performance controller gain values optimized considering nature inspired meta heuristic algorithm namely ant colony optimization technique using different objective functions time domain specification analysis considered evaluate performance investigated power system power system designed modeled matlab simulink environment finally simulation results established time absolute error objective function based pid controller provided superior performance compared objective function based pid controller
appropriate structural analysis optimization methods great significance conceptual design automotive body white structure paper simplifies structure spatial semi rigid framed structure provide early stage predictions novel exact transfer stiffness matrix method proposed static dynamic analyses three dimensional semi rigid framed structures matrix storage equation solution techniques large scale engineering structures also considered additionally size optimization mathematical model conceptual structure formulated solved genetic algorithm afterwards promote conceptual design structure object oriented matlab toolbox based developed unified modeling language strategy design pattern employed facilitate development toolbox distributed parallel computing technique adopted speed former sequential optimization algorithm simple modifications lastly validity easy used toolbox demonstrated benchmarking auto body elsevier ltd rights reserved
known low testosterone high cortisol levels associated hypertension chronic stress linking stress elevated blood pressure however association acute stress chronic stress responses clear therefore examined association cortisol psychological distress responses low high male subgroups beat beat ambulatory blood pressure measures obtained serum samples collected analyzed sex hormones cortisol chronic psychological distress verified general health questionnaire acute stress cold test chronic psychological distress observed low high compared low tended ischemic events values groups chronic distress cortisol acute stress total peripheral resistance cold responses associated low african group acute chronic stress contribute increased low african men cortisol vascular responses supported tendency ischemia increasing risk coronary artery disease
women younger years face early menopause premature ovarian failure cause idiopathic especially cancer induced radiation therapy current treatments including hormone replacement therapy techniques increased risk ovarian cancer malignant cells technique regarded novel regenerative medicine strategy organ replacement wherein living cells organ removed leaving extracellular matrix ecm cellular study aimed produce ovary ovary scaffold platform ovary regeneration transplantation developed novel protocol porcine ovary treatment physical chemical enzymatic methods using hematoxylin eosin staining staining scanning electron microscopy sem quantitative analysis approach proved effective removing cellular components preserving ecm furthermore results biological safety evaluation demonstrated ovary tissues rat ovarian cells vitro caused minimal immunogenic response vivo addition ovary tissues successfully supported rat cell penetration vivo showed improvement estradiol hormone secretion
concept heavy metal used toxic toxic metal heavy metals effective high density low concentrations systems action mechanism heavy metals depends concentration effects heavy metal vary depending nature species metal ions complex organisms yeast effects often research subject recent years addition preventing disease effect heavy metals copper lead aluminum animal human metabolism effects yeast metabolism subject scientific studies study revealed effects heavy metal lead copper aluminum toxicity mda fatty acids vitamin cerevisiae addition study demonstrated effects heavy metal toxicity antioxidant systems removal heavy metal toxicity cerevisiae via antioxidant systems great importance removal heavy metal toxicity living organisms avoid heavy metals especially increase mda levels showed accumulation heavy metals caused severe damage living cells difficult explain principles antioxidant defense system living organisms antioxidant defense system affected environmental changes therefore different results obtained cerevisiae cells results present study showed different heavy metals different effects antioxidant defense system
several studies meta analyses demonstrated efficacy combination nicotine replacement therapy patients wish quit smoking however limited guidance respect initiation combination review evidence rationale behind combination present dosing used combination studies propose step approach combination integration behavioral strategies published elsevier inc
large body research revealed language processing fundamentally non selective simultaneous graded activation mental representations speakers languages equally deep tradition research code switching mixing revealed important role principles play determining nature speech propose integrate two within formalism gradient symbolic computation allows integration principles gradient mental representations apply framework code mixing constructions element intended appears languages within single discuss directions suggests future research
paper presents approximate time domain solution physics based electrochemical lithium ion cell battery models time domain solution represented state space form easily used design state estimator controller uses interconnection system approach derive state space representation battery impedance model provides reduced order model based via balanced method simulation results also provided show performance proposed model frequency domain elsevier rights reserved
objectives long term effectiveness data real world relapsing remitting multiple sclerosis needed objective report long term effectiveness safety cohort patients methods retrospective study treatment two years longer relapse rate expanded disability status scale brain magnetic resonance imaging lesion volume virus antibody status previous treatments adverse events analysed results seventy one patients included mean treatment duration months treatment duration significant decrease relapse rate evidence clinical disease activity one two years respectively brain magnetic resonance imaging lesion volume remained stable forty patients suspended due high risk developing progressive major complication conclusions showed effectiveness long term follow period cohort reduction mri lesion load stabilization major complication elsevier rights reserved
chronic infectious disease caused mycobacterium according official reports countries across five regions newly diagnosed cases although affects skin peripheral nerves present across spectrum clinical histopathological forms strongly influenced immune response infected individuals forms comprise specific also response limits multiplication specific regulatory responses control replication rather allow bacterial dissemination borderline clinical forms present similar less extreme immune biases acute inflammatory episodes known reactions complications occur treatment cause neurological damages cause irreversible chronic disabilities review discusses innate adaptive immune responses interactions known affect pathogenesis influence clinical outcome
design nonlinear observer extended nonlinear system resulting parameterized linear single input single output system studied observability assumption system existence observer concluded second step novel algorithm identification system suggested compared adaptive observers available literature advantage low dimension strict lyapunov function
objective explore serum levels patients atrial fibrillation evaluate role biomarker incident heart failure methods three hundred five patients enrolled study divided three groups sinus rhythm group paroxysmal group persistent group serum concentrations measured enzyme linked immunosorbent assay baseline clinical characteristics laboratory data collected hospitalization follow months carried results serum concentrations significantly decreased group highest concentrations patients found group studies subjects lower concentrations likely become paroxysmal much lower middle upper participants tended suffer compared lower group conclusion provide evidence significant meaning patients levels related new onset
upon apoptotic stimuli lysosomal proteases including released due lysosomal membrane trigger apoptosis via lysosomal mitochondrial pathway apoptosis herein mechanism investigated found caspase cleaved bid result directly although bax modestly enhance triggered necessary study large vesicles model membranes mimicking lipid used membrane process vitro found acid one major acidic found membrane essential induced facilitates insertion deeply lipid undergoes triggers formation highly curved lipid phases events induce via pore formation mechanisms encapsulated conjugated released significantly due smaller molecular size basis data proposed interactions lysosomal membranes form pores result noted cleaved bid potent binding lipid promoting amplification mechanism likely contributes apoptotic signaling acid mediates targeting induce lysosomal membrane apoptosis lipid res
background genomic selection uses information genomic signatures consisting thousands genetic markers predict complex traits represents promising approach accelerate tree breeding especially relevant genetic improvement characterized long breeding cycles present study tested advanced breeding population black growth wood quality traits concurrently examined factors affecting model accuracy results study relied year old trees belonging full families derived parents established two contrasting sites genomic profiles obtained single nucleotide polymorphisms snps representative many gene loci distributed among linkage groups common models obtained four growth wood traits validation using independent sets trees showed model accuracy high related trait heritability equivalent conventional based models forward selection gains per unit time three times higher approach conventional selection addition models also accurate across sites indicating little genotype environment interaction area investigated using information half instead full led significant reduction model accuracy indicating inclusion relatedness model contributed higher accuracies markers sufficient obtain model accuracy almost equivalent obtained markers whether spread across genome single linkage group confirming implication relatedness potential linkage high accuracy estimates obtained slightly higher model accuracy obtained using marker subsets identified carry large effects indicating minor role short range population conclusions study supports integration models advanced generation tree breeding programs given high genomic prediction accuracy obtained relatively small number markers due high relatedness family structure population breeding programs similar ones long breeding cycles much larger gain per unit time obtained genomic selection early age conventional approach thus appears highly especially context forward selection species amenable mass propagation selected stock
investigated effects ethyl methyl carbonyl amino acid novel type receptor agonist induced ear inflammation mite antigen induced dermatitis mice oral administration significantly suppressed induced ear swelling dose dependent manner addition significantly alleviated mite antigen induced atopic dermatitis like skin lesions mice histological analysis revealed significantly reduced epidermal thickness number mast cells infiltrating skin lesions demonstrated inhibited mite antigen induced accumulation skin lesions endogenous ligand induced migration vitro moreover confirmed levels significantly increased skin lesions mite antigen induced dermatitis model together results suggest inhibits skin inflammation mice blocking activities karger basel
maximum operational range continuous variable quantum key distribution protocols shown improved employing high efficiency forward error correction codes typically secret key rate model protocols modified account non zero word error rate codes paper demonstrate model incorrect firstly show example fixed rate error correction codes currently defined exhibit efficiencies greater unity secondly show using secret key model combined greater unity efficiency codes implies possible achieve positive secret key breaking channel impossible scenario consider secret key model post selection perspective examine implications key rate constrain forward error correction codes operate low word error rates
background renal syndromes occasionally reported domestic animals two identical twin grey exhibited weight loss skeletal abnormalities delayed development associated kidney abnormalities formation signs inherited renal tubular dysplasia found japanese black cattle associated mutations gene despite demonstrating striking phenotypic similarities obvious presence pathogenic variants candidate gene found therefore analysis required genetic etiology condition results family history cases suggested possibility autosomal recessive inheritance mapping combined sequencing whole genome one case detected two associated non private coding variants homozygous missense variant gene located sized region homozygous deletion cofactor gene located region pathogenic variants previously associated inherited metabolic syndromes different species including japanese black cattle genotyping two additional clinically cases confirmed association variant animals homozygous mutant genotype show variant allele identified genomic deletion predicted highly disruptive creating premature termination translation resulting severely truncated proteins lack two functionally essential domains variant allele absent cattle approximately carriers detected among genotyped grey cattle biochemical analysis one case revealed presence approximately conclusions identified loss function variant highly likely cause renal syndrome affected animals results suggest phenotypic features renal syndrome related early onset form highly likely lead progressive defects identification candidate causative mutation thus enables selection pathogenic variant grey cattle
paper proposed new approach detection faults linear analog circuits approach simple efficient based signal flow graph approach also used calculate tolerance component important parameter circuit paper describe whole method testing linear analog circuits approach tested two analog circuits integrator circuit mimo circuit model calculation approach done help matlab simulink tool
student dropout rate universities fascinating especially among students electrical engineering even developed european countries face dropout rate engineering students first year rate high engineering disciplines problem calls attention educators university administration take measures help reduction dropout rate assist students successfully completing degree among many solutions control student dropout rate one adoption prediction mechanism whereby students potentially poor performance improve performance resulting better grades existing prediction mechanisms apply various machine learning techniques student cognitive features addition non cognitive features also significant impact students performance however applied prediction research aims improving existing prediction mechanism exploiting cognitive non cognitive features students predicting results found result analysis addition cognitive features increases prediction accuracies decision tree however addition play significant role techniques study also identified individual cognitive features considered students universities drop
parkinsons disease debilitating neurodegenerative disorder characterized intracellular inclusions comprised primarily alpha synuclein alpha also transmitted neuron neuron several lines evidence suggest inclusions cause neurodegeneration thus exploring strategies improve neuronal survival neurons alpha aggregates critical previously exposure alpha pre formed shown induce aggregation endogenous alpha resulting cell death exacerbated either inhibition mtor rapamycin able induce autophagy intracellular protein degradation pathway since mtor inhibition also inhibit protein synthesis detrimental neuronal survival investigated effects autophagy induction neurons alpha inclusions mtor independent autophagy induction mechanism exposed mouse primary cortical neurons induce inclusion formation presence absence proposed induce autophagy stimulate lysosomal biogenesis expected observed exposure increased abundance alpha aggregates cell death alone increased levels consistent increased levels remained elevated exposure interestingly alone increased cell viability time course also able restore cell viability control levels still exhibited toxic effects cells data provide essential information regarding effects accumulation neuronal survival exposure
response surface methodology used model optimize immobilized candida lipase synthesis butyl methyl determine optimum conditions four factor five level central composite design used factors studied enzyme load reaction temperature methyl methyl concentration concentration quadratic polynomial regression model used analyze experimental data confidence level results indicated approach gave reasonable results optimization reaction parameters range tested parameters optimal conditions enzymatic reaction obtained mol methyl methyl mol using degrees rpm conditions percentage kinetic modelling enzymatic synthesis illustrated initial rate data progress curve data used suitable model kinetics found ternary complex ordered model inhibition substrate methyl methyl values kinetic parameters obtained nonlinear regression analysis found mol mol mol mol
hepatitis virus hcv infection represents world health problem protective vaccine effective drug currently exists economic reasons many patients use traditional medicines control infection egypt milk one traditional medicines widely consumed patients infected hcv present study aimed evaluate efficacy milk treatment patients infected hcv whole milk local farm administered patients months day patient patient sera collected prior following milk drinking three markers set sera evaluation three markers indicating effect milk hcv infection liver function assays alanine aminotransferase aspartate aminotransferase viral load assay anti hcv antibodies profile synthetic hcv epitopes milk demonstrated ability improve general fatigue health liver function levels reduced similar patients reduced patients subsequent drinking milk four months majority patients responded positively milk treatment rna viral load decreased patients one patient exhibited following milk treatment anti hcv antibodies profile significantly decreased immunoglobulin following treatment patients however treatment ineffective patients experienced reduction rna viral load following treatment milk conclusion whole milk treatment demonstrated efficacy vivo viral load majority patient sera reduced igg profile converted immunity
introduction patients non small cell lung cancer nsclc interstitial lung disease ild high risk acute exacerbation ild ild treated systemic chemotherapy standard treatment nsclc complicated ild established purpose methods examine whether type ild categorized official statement idiopathic pulmonary fibrosis ipf high resolution computed tomography predict chemotherapy induced ild nsclc patients ild retrospectively reviewed patients nsclc complicated ild received chemotherapy institute january december patients characteristics pathology clinical staging lung cancer chemotherapy type ild ild chemotherapy evaluated ild classified according statement follows usual interstitial pneumonia possible inconsistent pattern results total patients pre existing ild received chemotherapy mean age years range years fifteen patients ild developed chemotherapy induced ild seen frequently patients ild pattern possible pattern patients pattern inconsistent versus multivariate analyses including age sex performance status radiographic patterns ild showed presence possible pattern independent risk factor chemotherapy induced ild conclusions ild pattern possible pattern classification risk factor ild nsclc patients ild
child sexual exploitation received considerable attention last years evidence pointing increased risk young people learning disabilities however study specifically focused little known best protect identify support group paper based study examined identification support sexual exploited young people learning disabilities data collection included surveys local authorities sample services supporting vulnerable disabled children depth interviews professional stakeholders young people learning disabilities risk experienced paper provides overview study identifies areas improvement policy practice including need education training awareness raising amongst young people families professionals tackling social isolation young people learning disabilities need full implementation government guidance group young people elsevier ltd rights reserved
france endurance specialists twin family studies shown approximately variance number performance related phenotypes whether measured baseline natural response training including important cycling explained genetic variation research specific genetic variants responsible identified genes containing common genetic variants involved genetic predisposition physical performance however typically explain small portion variance perhaps collectively rarely explain approaching variance identified twin family studies thus gap understanding relationship heritability performance gap investigation rare variants epigenetic variation altering study designs increased collaborations pool existing cohorts together initial findings efforts show promising results mini review touch genetics epigenetics sporting performance relate france best future efforts directed discuss preliminary research findings
accumulating evidence suggests post diagnostic insulin levels influence colorectal cancer crc survival yet previous study examined crc survival relation post diagnostic diet rich foods increase post insulin levels hypothesized glycemic insulin scores index load derived food frequency questionnaire data associated survival specific crc subtypes sensitive insulin signaling pathway prospectively followed crc patients nurses health study health professionals follow study resulting crc deaths person years crc subtypes defined seven tumor biomarkers mutations expression implicated insulin signaling pathway overall crc subtype hazard ratio confidence interval increase one standard deviation glycemic insulin scores estimated using time dependent cox proportional hazards model found insulin scores glycemic scores positively associated crc mortality index load significant positive associations appeared pronounced among wild type cases negative cases ranging across insulin scores however observe statistically significant interactions insulin scores tumor marker interaction additional studies needed definitive evidence high diet crc diagnosis contribute worse crc survival new elevated circulating insulin levels associated colorectal cancer crc pathogenesis also linked crc survival according report contribution crc prognosis potentially reflected differences diet mortality association tumor biomarkers related insulin signaling pathway prospective cohort study crc patients high diet linked poor crc survival primarily wild type negative though interactions statistically significant insulin scores also significantly associated cause mortality among negative cases associations detected glycemic scores crc mortality
products several specific components submitted large number genetic tests studies gave negative responses results studies suggest components products particularly activity assessment profile substances light data animal human metabolism kinetic studies human clinical trials rodent studies support concerns pose risk humans consumed prescribed use conditions wiley liss inc
theme article protection electrical circuits negative sequence currents sinusoidal waveforms suggested solution enhancement instrument current transducers used industrial control applications instrument negative sequence current transducer connected coils designed authors presented article protect circuits extremely non sinusoidal currents waveforms instrument transducers order low pass filter suggested presence higher order harmonics protected three phase circuit low pass filter reduce thd output voltage instrument negative sequence current transducer compared harmonics currents protected circuit compensate differentiation effect typical transducer schemes paper interest investigators engineers engaged research design protection control equipment current instrument measurement devices used industrial applications also undergraduate students electrical engineering elsevier ltd rights reserved
describe new method extracts salient object surfaces medical volume data extraction one popular methods volume visualization contour connected component often represents boundary surface independent object image however infinite number defined image even one single many therefore problem effectively finding contour represents region interest becomes important method uses contour tree user interface extracting salient contour tree represents possible topological structures geometric properties contour computed used label contour tree width color branches topological geometric properties guide users select salient contour surfaces extracted using propagation seed cells derived tree fully utilize multicore cpus gpus extraction process obtain enough method applied various medical data sets results showed method seven times faster previous methods salient contour surfaces representing important features data
previously reported sulfate expressed articular cartilage knockout mouse developed severe knee osteoarthritis study hypothesised intra articular injection prevent cartilage degeneration confirming induce cell death vitro gene expression type collagen matrix metalloproteinase mmp presence determined quantitative real time polymerase chain reaction also injected intra mice following surgical medial produce model osteoarthritis cartilage degeneration evaluated mmp staining also investigated fibroblast growth factor extracellular signal regulated kinase erk cell signalling western blotting exposure vitro increased type collagen expression decreased mmp expression concentration dependent manner injection mouse knee significantly suppressed loss mmp expression signalling pathway activation significantly reduced findings indicate prevents cartilage degeneration suppressing mmp via effect signalling
ambient noise variability critical challenge encountered multiple stakeholders including designers operators among sources ambient noise ocean wind related noise significant impact performance tropical waters indian ocean region present random fluctuations surface parameters namely wind speed surface temperature wave height etc resulting variations ambient noise characteristics site specific surface fluctuations tropical regions restrict possibility generalized algorithm design mitigate ambient noise impact work attempts study variations ambient noise levels corresponding fluctuations surface parameters site specific behavior tropical demonstrated using surface data available three distinct locations analysis methodology used characterize predict improve performance particularly severe conditions tropical
introduction cardiovascular risk marker tissue activator antigen reduced long term exercise interventions unknown whether due weight loss induced physical activity due physical activity per materials methods tested healthy younger years overweight bmi men randomly assigned weeks intervention one four groups training energy reduced diet training increased diet sedentary lifestyle unchanged diet controls fasting blood samples obtained weeks intervention analyzed plasma results body weight reduced groups observed decrease baseline weeks three exercise diet intervention groups change control group group difference observed weeks due lower values compared control group total body fat mass reduced three exercise groups observed positive correlation changes changes intra abdominal subcutaneous adipose tissue volume conclusions results demonstrate reduced three intervention groups suggests weeks endurance training per irrespective concomitant weight loss affects cardiovascular risk healthy younger overweight men elsevier ltd rights reserved
applied hydrogel system general therapeutic mask delivery hydrophobic efficient due differences polarity polymer network work presents study developing based matrix delivery hydrophobic type active rich palm based vitamin skin strength flexibility hydrogel increased inclusion potassium citrate thermogravimetric analysis tga results indicated higher quantity water hydrogel differential scanning calorimetry dsc showed three types water molecules existed hydrogel hydrogel non according test guideline vitro skin irritation test hydrogel fluids able membrane bioavailability improved inclusion peg oil mixture therefore based hydrogel potassium citrate successfully developed good strength flexibility without potential good bioavailability loaded hydrogel used skin care application
based previous studies linked emotional disorders including depression memory biases aim present study assess relation depression memories negative life events specifically aimed investigate individual differences depressive state false memories study occurrence false memories video paradigm used videos related details shown presented recognition task order induce spontaneous false memories sample participants completed study exchange course credits watching video participants reported current depressive state completing beck depression inventory watching video participants completed recognition task asked indicate whether seen particular detail video results revealed significant differences level memories reported specifically participants high level depression reported low level memories compared participants low level depression differences participants low level depression participants high level depression false memories significant results discussed perspective clinical implications
background anorexia nervosa developmentally important early years many young people knowledge insufficient regarding course treatment outcome prognosis naturalistic studies conducted within field eating disorder research naturalistic study included adolescents subthreshold treated outpatient care overall aim examine sample characteristics treatment outcome additional aims examine potential factors associated remission outcome variable possible differences three time periods treatment onset methods participants identified swedish national quality register eating disorder treatment patients registered treatment onset followed year end treatment inclusion criteria medical self referral one participating treatment units years age initial entry diagnosed subthreshold total sample consisted patient different treatment units results results show participants remission approximately within healthy weight range ended treatment according plan remission within healthy weight range average treatment duration approximately months one third patients terminated treatment associated decreased chance achieving remission remission rates weight recovery increased time treatment duration decreased considering treatment outcome results show differences patients subthreshold conclusions present study shows relatively good prognosis adolescent patients subthreshold routine care results indicate treatment adolescents sweden become effective past years results present study contribute scope treatment research large scale naturalistic setting generalizability clinical environment however research needed different forms evidence new research strategies diversity treatment approaches
expansion electricity grid connected photovoltaic sources requires development solutions solving problems caused disturbances electrical network due strong variable character energy sources power generation grid connected photovoltaic plants increasing world plants crucial part future electric energy system restrict level electromagnetic disturbance currently effective technical solutions based power electronics paper deals issue power quality alteration assessing power electronics equipment operation mode grid connected plants normal restricted conditions operation general analysis performed first section identifying current state art photovoltaic plants influence power quality example designed starting real electric distribution system order create general image issues solutions
study stress protein response maximal exercise humans investigated eleven healthy males performed maximal actions muscle biopsies collected min exercise cellular regulation localization heat shock protein alpha analyzed immunohistochemistry elisa technique western blotting additionally mrna levels alpha quantified northern blotting exercise min showed strong staining gradually decreased following week alpha changes observed exercise min elisa analysis showed reduction level cytosolic fraction whereas western blotting revealed fold increase level fraction cytosolic level increased control level exercise days bound increased similar fold accompanied strong staining cross sections mrna levels alpha elevated first day exercise mrna showed largest increase fold alpha seemed respond immediately maximal exercise binding cytoskeletal proteins probably function disrupted structures later mrna total protein levels especially increased indicating play role skeletal muscle recovery remodeling adaptation processes high force exercise
paper sensitivity look ahead economic dispatch real time power markets respect data perturbation studied look ahead dispatch optimization problem small change data used setting temporal equality inequality constraints objective function negatively affect normal operations calculation real time electricity prices operating costs lead distorted prices larger operating costs look ahead dispatch static dispatch use data single future time conditions look ahead dispatch optimization formulation using derive linear sensitivity matrix assesses impact data look ahead dispatch matrix illustrates changing optimal solution look ahead dispatch subject potential various types spatial temporal data generators cost coefficients capacity limits generators transmission lines rates estimate initial generation output constraints multiple time series forecast load look ahead horizon results simulation illustrated numerical examples ieee bus system
naturally wide variety plays important roles host reproduction previously reported infect means pcr sequencing found study indeed present phylogenetic analysis indicates infection occurred via transfer parasitic furthermore southern blotting results suggest lateral transfer gene genomes wild antibiotic treatments found eliminate important ovary development results provide clues towards comprehensive understanding interaction possibly insects
control systems heating ventilation air conditioning non domestic buildings often operate fixed schedules assuming maximum occupancy business hours since lower usually mean less demand heating ventilation air conditioning energy savings made air quality sensing often combined temperature sensing performed sufficiently past maintained properly although sensor control failures increase energy use much energy costs increase coupled increased complexity building services reduced time placing ever higher demands sensing building controls meet increasingly stringent environmental requirements whilst also improving reliability sensor fusion offers performance resilience meet demands cost privacy key factors also met article describes neural network approach sensor fusion occupancy estimation feature selection carried using symmetrical uncertainty analysis fusion sensor features used back propagation neural network count accuracy exceeding
essay analyze three plays spanish goal exploring authors intriguing power structures configuration gender roles engaging modern interpretation three three works examines way male female relations shaped suggesting mainly need adopt models identity positive effect society lead greater female male subjects
aim paper present mobile agents model distributed classification big data great challenge optimize communication costs processing elements parallel distributed computational models way ensure scalability efficiency method additionally proposed distributed method integrates new communication mechanism ensure hpc high performance computing parallel programs distributed one means cooperative mobile agents team uses asynchronous communication ability achieve mobile agents team implements distributed method fuzzy means algorithm performs big data classification distributed system paper shows proposed scheme assigned algorithm presents experimental results illustrate scalability efficiency distributed method
algebraic algorithmic study differential operators started past decade differential operators allow particular study initial value boundary problems linear algebraic point view differential operators already provide rich algebraic structure wealth results algorithmic methods adding integral operators evaluations many new phenomena appear including zero non generated tutorial give introduction symbolic methods differential operators boundary problems developed last years particular discuss normal forms basic algebraic properties computation polynomial solutions ordinary differential equations polynomial coefficients also outline methods manipulating solving linear boundary problems illustrate implementation
surgical trauma muscle potential cause post headache disorders aim study evaluate prevalence pain dysfunction trigeminal somatosensory abnormalities patients acquired following fifteen patients evaluated surgical procedure trained evaluation consisted research diagnostic criteria standardized pain questionnaire systematic protocol quantitative sensory testing trigeminal nerve subjects patients developed pain triggered mandibular function pain intensity measured using visual analog scale vas mean pain intensity prevalence dysfunction significant reduction maximum mouth opening sensory evaluation showed thermal area access patients high frequency dysfunction postoperative pain trigeminal sensory abnormalities findings help understand several abnormalities contribute postoperative headache pain complaints surgeries
paper addresses problem state parameter estimation class affine systems state space representation method require specific state representation system consists designing switched observer certain conditions given paper allows state parameter estimation errors converge zero assuming parameters estimated belong given idea method parameter estimation problem switching rule design auxiliary switched system whose matrices equilibrium correspond matrices system estimated guaranteed cost used design switching rule based max composition set quadratic functions observation error method simple low computational cost main disadvantage regards amount information needed state parameters estimated simultaneously case parameter estimate method reduces standard observer guaranteed cost
researchers believe mature mammals restricted zone gyrus zone lateral ventricle central nervous system peripheral nervous system thought active prenatal development exception olfactory however sensory ganglia adult peripheral nervous system reported contain precursor cells vitro induced differentiate neurons occurrence induced reported several investigators brain limited recent reports peripheral nervous system reports suggest damage adult nervous system induces mechanisms similar control generation new neurons prenatal development understanding conditions induced physiologically non neurogenic regions adults one major challenges developing therapeutic strategies repair neurological damage however induced peripheral nervous system still largely unexplored review presents history research adult peripheral nervous system dates back years reveals evidence estimated potential generation new neurons adult peripheral nervous system
study examines association self reported impulsivity self injury suicidal ideation suicide attempts completed clinical sample finnish adolescents aged treated psychiatric inpatient care april march schedule affective disorder schizophrenia school age children present lifetime interview used gather information psychiatric disorders impulsivity suicidality adolescents mortality data obtained national cause death register adolescent girls impulsivity significantly associated suicidal ideation attempts completed adolescent boys adolescent boys impulsivity died suicide follow time preventive purposes health care professionals encouraged asked adolescents targeted questions impulsivity consider associated risk suicidality identified study
paper analyses one important control system design issues controller performance blending process modeled first order plus dead time selected design closed loop pid controller tuning controller parameters done using tuning techniques performance pid controllers evaluated comparing set point tracking disturbance rejection capabilities
paper optimal input load disturbance rejection controller integrating processes dead time proposed based internal model control principle main contribution work optimal solution criterion integrating processes dead time input constant disturbances derived based algebraic theory improve performance set point tracking input disturbance rejection two degree freedom control design method also developed compared previous advanced control methods proposed design method three main advantages first optimal controller derived systematically basis algebraic theory designed controller given analytical form second simple tune principle developed set point tracking performance specification robustness stability specification quantitatively achieved tuning performance degree designed controller finally optimal set point tracking performance input disturbance rejection achieved proposed control structure numerical simulations given illustrate effectiveness proposed method
sustainable rural food systems poor vulnerable people need locally adapted enhance food security requires participatory action research considers entire food value chain fvc paper presents assessment feasibility potential success strategies ups enhancing food security based study part larger participatory research project two regions authors present results relating natural resource management crop production results natural resources show enhanced soil water management rated high semi arid region region experts soil fertility improving ups conservation agriculture assessments food production regions indicated importance input pest disease control cover crops assessments differed greatly two different climatic regions lesser extent experts gender highlights importance including different south north female male awareness assessments implementation feasibility assessments ups indicated suitable approaches rainwater harvesting semi arid conservation agriculture regions respectively local regional stakeholders experts involved developing assessing site adapted ups enhancing
detailed publications allow performing associations technical aspects occurrence injuries purpose study apply methodology based recording material assess injury risk factors common techniques regular training used case study novice students men women university five academic years ordinary training period technical execution ten techniques obtained data evaluated using descriptive statistics patterns analysis thus possible identify presence typical execution technique main temporal sequence errors allowing link findings injury occurrence order narrow unexpected causes accidents regarding poor technique performance regular training research provides hidden temporal sequence errors common techniques helping professionals correct key technical errors order prevent diverse type injuries methodology developed easily extended sports
atp mortality icd patients atp effective treatment ventricular reduce frequency patients implantable icd association survival atp compared shock confirmed large patient population study aims determine patients icd receiving atp lower mortality compared receiving shock nine thousand three hundred sixty eight patients underwent icd implantation october enrolled remote monitoring network medical usa patients categorized three groups based type icd therapy received follow therapy atp shock groups survival determined linking implant records social security death index resultsthe therapy hazard ratio confidence interval atp groups associated lower mortality risk shock group results unaffected age gender device type atrial fibrillation burden ventricular rate atp effective episodes atp effectiveness dependent ventricular rate rates higher icd patients received atp compared therapy icd patients received shock higher mortality compared groups furthermore data suggest age gender device type burden rate arrhythmia change trend higher mortality patients receiving icd shock compared atp alone
psoriasis chronic inflammatory disease appearing cutaneous lesions characterized infiltration immune cells helper helper cells demonstrated structurally related terminal amino acids alpha stimulating hormone previously shown exhibit anti inflammatory effects intestinal inflammation ameliorated ongoing disease mouse model induced psoriasis like skin inflammation small mouse model psoriasis show systemic treatment significantly reduced murine human skin moreover upregulated cells mice peripheral blood individuals psoriasis decreased expression type inflammatory cytokines indicating beneficial effect least part mediated induction functional regulatory cells suppressed activation pathogenic ifn cells thus data suggest potential novel therapeutic alternative treatment psoriasis
electrical circuits connect biosensors actuators plants trees many electrochemical components devices plants created nature participate electrical signal transduction actuators electrical processes play important roles physiology plants trees fruits seeds electrical form energy entropy content used work information transfer computing analysis signals propagate along sophisticated electrical circuitry plants consisting many electrical components cell computing system decision making processes action potentials mediators intercellular intracellular communication response environmental stresses graphics
advances understanding human pain experience shifted much focus pain research periphery brain current hypotheses suggest progression migraine depends abnormal functioning neurons multiple brain regions accordingly sought capture functional brain changes induced application inflammatory known inflammatory across multiple brain networks specifically aimed determine whether alters additional neural networks indirectly related primary pathways via spinal cord thalamus cortex comprises acidic combination bradykinin serotonin histamine prostaglandin introduced basic pain research tool activate peripheral studying pathological pain conditions associated using model intracranial pain found application fully conscious rats enhanced hypothalamic hippocampal somatosensory cortex responses mechanical stimulation face compared sham synthetic interstitial fluid administration furthermore resting state mri data revealed altered functional connectivity number networks previously identified clinical chronic pain populations included default mode sensorimotor salience autonomic networks findings suggest activation sensitization enhance extent brain processes signaling define new level modulation affective cognitive responses pain set new tone hypothalamic regulation autonomic outflow change cerebellar functions published elsevier
large number diseases occurring constituents impaired provides striking evidence key role maintaining tissue integrity detailed understanding molecular alterations causing dysfunction turn development novel diagnostic tools salient clinical implications oral medicine practitioners majority diseases affect oral cavity present article review autoimmune infectious genetic neoplastic diseases target particular emphasis clinical manifestations diagnostic pathways relevant laboratory investigations
patients advanced parkinsons disease eligible deep brain stimulation referred specialized centers survey evaluated reasons reluctance patients referring physicians regarding two different questionnaires containing multiple choice open questions developed one one patients first questionnaire sent private practice catchment area authors medical center second patient support groups region help german parkinson association addressed completed questionnaire estimated risk hemorrhage severe complication average concerned patients developing mood changes depression felt unable care patients already personal experience patients reported good clinical outcome patients although claimed know specific criteria actively describe state three main criteria patients completing questionnaire obtained information regional patient organizations also physician assumed risk severe complications satisfied medical treatment reported considered treatment option latter numbers indicate treating tend reluctance patients undergo therefore education patients improved give realistic figures actual outcomes frequencies possible complications
air pollution major environment related health threat studies toxicity verified cardiovascular system endothelial cells however researches induced myocardial related toxicity limited study aims fully understand toxic effects human myocardial cell explore molecular mechanism based microarray analysis bioinformatics analysis microarray data analysis manifested induced toxicity affected expression genes compared control group including upregulated genes downregulated genes human myocardial cells analysis showed cellular processes immune response cell maturation embryonic heart tube morphogenesis cellular response electrical stimulus skeletal muscle tissue regeneration negative regulation signal transduction upregulated regulation transcription dna dependent rhythmic process protein apoptotic process innate immune response downregulated pathway analysis indicates cell signaling pathways cytokine cytokine receptor interaction kappa signaling pathway chemokine signaling pathway endocrine factor regulated calcium infection cell adhesion molecules upregulated tgf beta signaling pathway downregulated addition signal net showed genes significantly decreased expression gene markedly increased compared control group genes verified qrt pcr study provided new bioinformatics evidences induced myocardial tissue toxicity necessary cardiovascular system toxicity studies
combined fast fourier transform fft mathematical hybrid method accurately computing current flowing along grid buried earth model developed paper hybrid method electrical circuits consist typical elementary element accelerate calculation dynamic state quasi static complex image methods closed form function introduced model model used study performance transient response grid
expression novel protein tyrosine phosphatase interacting protein investigated mrna protein level liver adult wistar rats presence mrna detected northern blotting immunostaining showed expression protein distinct non cells cells identified cells cells natural killer cells detection cell specific antigens whereas endothelial cells large vessels reacted positive antibody sinusoidal endothelium showed detectable amount furthermore also found expressed cells forming tree additional subcellular analysis non cells means electron microscopy showed presence protein cytoplasm nuclei non cells hepatocytes show immuno detectable amount yet revealed protein either cytoplasm nucleus
importance electric aircraft highlighted many publications projects industrial presentations definition electric aircraft concept achieves majority required system functionality using electrically powered sub systems components manifests much higher electrical power demands board aircraft compared conventional architectures presents many challenges design process alleviate risk choose optimum architectures systems aircraft essential incorporate characteristics possible configurations electrical network conceptual preliminary design stages hence current practice performing electrical load analysis detailed design stage adequate address gap paper presents viable robust methodology define requirements size components systems calculates electric power requirements preliminary design stages methodology uses conventional aircraft systems components baseline uses mathematical techniques logical sequences component operation developed research size electrical load profiles conventional aircraft result electric aircraft concept adding key components account difference conventional system electric system methodology presented makes design process robust aids choice optimum design aircraft
nonverbal behaviors exhibited patients depression interactions others reflect social depression maintenance investigations associations depression patients behaviors scarce restricted european samples study examined whether nonverbal behavior patients associated depression severity recovery cultural differences explored seventy eight depressed outpatients dutch evaluated week pharmacological treatment patients hamilton depression scale interview treatment also treatment nonverbal behaviors patients speaking effort analyzed using two factor results revealed speaking effort associated influenced baseline depression severity however treatment whereas remained unchanged speaking effort increased among patients speaking effort associated patients culture exhibited higher speaking effort dutch findings highlight whereas supportive nonverbal behavior stable set nonverbal behaviors composed head movements eye contact gestures displayed patients speaking clinical interviews reflects depression persistence treatment
emergence addictive problems associated development information communication technologies challenge mental health modern societies reason spanish mental health strategy currently project includes problem emerging young people mental health topics analysed main objective research develop three screening tools used health staff psychologists physicians better link early detection early intervention field technological paper three kind technological selected internet social networks mobile video games two groups participants selected technology users internet social network mobile video games without psychological problems due use technologies people sought counselling advice addictive problems technologies three screening tools technological addiction internet social network mobile video games developed tools consist two items tests highest positive predictive values differentiate non problematic users technologies addictive problem internet mobile video games article shows three screening tools used health clinical staff case professional patient addictive problem three technologies screening procedure implemented diagnostic addiction confirmed patient treated psychological treatment based evidence also proposed need specialized intervention addiction
background prevalence allergic inflammatory diseases atopic dermatitis asthma allergic rhinitis worldwide increased complete recovery difficult korean red heat processed root widely frequently used traditional medicine east asia study investigated whether korean red water extract regulates expression proinflammatory cytokines chemokines via mitogen activated protein kinases nuclear factor kappa kappa pathway allergic inflammation methods compound induced shock induced like skin lesion mice models used investigate effects human keratinocytes cells human mast cells also used clarify effects expression proinflammatory cytokines chemokines results shock induced like skin lesions attenuated administration reduction serum immunoglobulin ige interleukin levels mouse models also reduced production proinflammatory cytokines including beta expression chemokines thymus activation regulated chemokine macrophage derived chemokine cells additionally decreased release tumor necrosis factor alpha tnf alpha beta expressions chemokines including macrophage inflammatory protein alpha beta regulated activation normal cell expressed secreted monocyte protein mcp cells furthermore data demonstrated inhibitory effects occurred mapk kappa pathway conclusion useful therapeutic agent treatment allergic inflammatory diseases like dermatitis korean society published elsevier korea llc
investigate controllable behavior soliton external potentials variable dispersion nonlinearity management functions describes propagation optical pulses inhomogeneous fiber system derive lax pair variable spectral parameter exact multi soliton solution generated via darboux transformation based solutions several novel optical solitons constructed selecting appropriate functions main evolution features waves shown interesting figures computer simulation examples periodic potential soliton compression exponentially dispersion decreasing fiber interaction solitons discussed presented results applications study soliton managed switching architecture results potentially useful management soliton external potentials optical soliton communications long networks
cardiovascular diseases leading cause death western world current development clinical diagnostics accurately measure extent goal better understanding structure function relation cardiovascular system much fundamental understanding comes development study models integrate biology medicine imaging information models provides guidance developing diagnostics implementation diagnostics clinical setting turn provides data refining models review introduce multi scale multi physical models understanding disease development progression designing clinical interventions begin multi scale models cardiac electrophysiology mechanics diagnosis clinical decision support personalized precision medicine cardiology examples arrhythmia heart failure introduce computational models vasculature mechanics associated mechanical forces understanding vascular disease progression designing clinical interventions elucidating mechanisms underlie diverse vascular conditions conclude discussion barriers overcome provide enhanced insights predictions decisions pre clinical clinical applications
objectives motivation change behavior important therapeutic factor affects treatment outcomes patients substance use disorders motivation level influences treatment engagement retention outcomes assessment motivation important aspect management patients methods total patients admitted addiction unit fulfilling diagnostic statistical manual mental disorders edition criteria one substance dependence disorder included patients assessed using stage change readiness treatment scale addiction severity index attending motivation incentives group psychotherapy sessions session week patients using sessions results increased scales groups however recognition scales showed significant increase respectively whereas increase taking steps scale statistically significant best fit model regression calculated factors group age patient education years main substance abuse either substances history suicide previous treatment trial positive negative medical history history alcohol use history legal problems presence family issues psychiatric complications predictors recognition taking steps components motivation conclusions short motivation incentives group therapy improve readiness change patients dependence
problem considered study nonlinear multiple time delay perturbed systems first neural network model employed approximate reduced order model plant linear differential inclusion state space representation established dynamics model based state space representation robustness design fuzzy control proposed system designed fuzzy controller system auxiliary fuzzy controller simultaneously introduced system frequency high enough outputs system corresponding mathematical model relaxed system made close desired makes possible obtain rigorous prediction stability system establishing relaxed system finally study provides numerical example simulations illustrate concepts discussed throughout article
east campaign new internal coil power supply used order enhance control vertical power supply now allows current voltage working modes much higher peak voltages currents faster response time comparison previous power supply allowed current mode pid composite controller designed voltage mode based optimal control theory rigid plasma response model paper demonstrate faster enhanced controllability realized combination pid controller large position drift controller export maximum voltage achieve much faster power supply response slow vertical displacement events pid controller used small finally stabilize minimum position oscillation furthermore evaluate time latency control system power supply stability performance closed loop simulated analysed controller finally implementation test east using quasi shape achieved growth rates paper shows new power supply using pid controller significantly enhance control vertical elsevier rights reserved
track one geosynthetic applications geosynthetic used multiple functions namely reinforcement separation filtration drainage present study static cyclic tests performed full panel railway track models laid soil tests performed model tracks two different thicknesses layers laid two different soils namely clay model tracks adequately instrumented record induced stresses displacements track model tracks reinforced geogrid geotextile suitable interfaces track conditions heavy rainfall simulated model tracks reinforced geogrid interface effective reducing tie displacements strains displacements compared model tracks reinforced geotextile interface clay used soil conversely model tracks reinforced geotextile performed better respect reduced tie displacement displacement strain compared model tracks reinforced geogrid used soil elsevier ltd rights reserved
background prostaglandin essential regulator ovulation contrast one gene one protein concept synthesis peptide signaling molecules production metabolism bioactive requires controlled expression many proteins correct subcellular localization enzymes coordinated synthesis metabolism prostaglandin transport cells facilitate action degradation elevated required successful ovulation disruption synthesis metabolism transport yield effective contraceptive strategies methods review summarizes case reports studies ovulation inhibition women treated cyclooxygenase inhibitors published findings discussed context studies describing levels mrna protein activity prostaglandin synthesis metabolic enzymes prostaglandin transporters ovarian cells results surge regulates expression component synthesis metabolism transport pathway within follicle data primary ovarian cells cancer cell lines suggest enzymes transporters optimize bioactive levels elevated mediates key events including expansion follicle rupture release inhibitors prostaglandin synthase enzyme also known cyclooxygenase reduce ovulation rates women studies show inhibitors reduce rates expansion release follicle rupture nuclear maturation fertilization inhibitor reduced pregnancy rates breeding administered simulate emergency contraception however inhibition prevent pregnancy monkeys administered simulate monthly contraceptive use conclusion inhibitors alone suitable use emergency contraceptives however drugs class unlikely effective monthly contraceptives inhibitors additional synthesis enzymes modulation metabolism transport also hold potential reducing follicular preventing ovulation approaches target multiple components synthesis metabolism transport pathway required effectively block ovulation lead development novel contraceptive options women therapies target also impact disorders uterus also benefits womens health addition contraception
due significant drop energy needed kwh kwh past years close theoretical minimum recovering salt free water seawater kwh focus critical aspects offer opportunities reduce costs include pre post treatment analysis optimization performance systems selectivity capacity flux decline flux decline includes concentration polarization inorganic organic biological constituents call three legs membrane processes approach quantitative includes detailed fluid mechanics associated mass transfer systems optimizing performance published elsevier
ternary metal oxides form rapidly emerging class new functional materials tackling challenge efficient solar energy harvesting currently main interest devoted characteristics materials little consideration given preparation solution combustion synthesis considered green sustainable alternative widely employed energy time consuming synthesis methods study employed prepare perform engineering foreign ion incorporation synthesized materials characterized powder ray diffraction transmission electron microscopy energy dispersive ray diffuse reflectance vis raman spectroscopy surface area determination via adsorption found materials formed synthesis phase composition materials amount foreign metal ions incorporated parent structure effectively controlled consequently technique provided simple reliable tool engineering photocatalytic activity materials tested methyl orange degradation intrinsic photocatalytic activity various samples compared effect different specific surface areas elsevier rights reserved
lactate ldh homologous core metabolic enzymes common nearly living organisms evolved least four times achieving altered substrate specificity different mechanism time instance ldh anaerobic parasites recently evolved independently gene duplication ldh plays central role metabolism reduction pyruvate lactate thereby required glycolysis using reconstruction methods identified biochemical evolutionary mechanisms responsible convergent event last common enzymes highly specific similar modern contrast ldh lineage evolved activity specificity gradual process involving one highly detrimental substitution specificity residue many additional mutations small effect different functional consequences indicating prominent role crystal structures modern day enzymes show evolution substrate specificity structural changes helix orientation relatively small specificity residue accommodate range substrate sizes permit solvent access active site promote substrate present multi independent evolution organisms illustrate diverse mechanisms protein function structure stability
bacterial septic arthritis rarely occurs upper extremities yet early diagnosis treatment important delay diagnosis results pain impaired hand function degenerative joint disease established procedure treating inflammatory arthritis osteoarthritis primary posttraumatic primarily achieve pain relief wrist deformity correction offers alternative option total wrist indications osteoarthritis joint concomitant intact joint present case study spontaneous fusion post wrist infection caused dog
work context feminine masculine rendering public service mirror gender asymmetry local government many face face services delivered cities counties largest job categories education police work almost elementary school teachers women less police women sequelae job component jobs pay glass change organizational logic nuanced appreciation gender
psoriasis common chronic inflammatory disease skin increasingly recognized systemic inflammatory disorder psoriatic arthritis known comorbidity psoriasis rapidly expanding body literature various populations settings supports additional associations psoriasis cardiometabolic diseases gastrointestinal diseases kidney disease malignancy infection mood disorders pathogenesis comorbid disease patients psoriasis remains unknown however shared inflammatory pathways genetic susceptibility common risk factors hypothesized contributing elements additional psoriasis comorbidities continue emerge education health care providers essential ensuring comprehensive medical care patients psoriasis
aims study investigated relationship subjective outcome assessment objective parameters injection patients overactive bladder oab methods total consecutive patients confirmed detrusor overactivity treated divided injections normal saline different sites primary end point change global response assessment months treatment patients monitored monthly treatment months patients divided successful failed treatment groups according change significant improvements months urgency urinary incontinence urgency episodes months compared patients significant difference noted groups months conclusions successful treatment outcomes injection oab patients associated improvement oab symptoms increased bladder capacity wiley periodicals inc
protein derived formed irreversible covalent modification amino acid residues example tryptophan found enzyme dehydrogenase biosynthesis requires cross linking rings two residues insertion two oxygen atoms onto adjacent one rings enzyme catalyzes completion within precursor protein substrate contains single hydroxyl group one catalyzes six electron oxidation assembly generates fully active oxidation reactions proceed via high bis state one heme present axial heme ligands provided amino acid side chains crystal structure complex revealed catalysis involve direct contact protein substrate rather accomplished long range electron transfer presumably generates radical intermediates kinetic site directed mutagenesis studies beginning elucidate protein controls reactivity mediates long range electron radical transfer required catalysis article part special issue entitled radical sam enzymes radical enzymology elsevier rights reserved
reported stress induce depression patients age sex moderating factors associations depression lifestyle korean adults addressed study designed examine relationships among stress problem drinking exercise depression differ age sex study korea health panel data utilized structural equation model using employed major findings follows women likely experience stress depression men individuals showed higher tendency toward stress depression age sex specific paths stress problem drinking exercise depression positively inter correlated path exercise depression indicated inverse association results indicate need evidence based stress management programs psychological korean adults
background drug induced interval prolongation risk factor life threatening ventricular arrhythmias potential side effect many medications contribution common genetic variants previously associated baseline interval drug induced prolongation arrhythmias known methods tested hypothesis weighted combination common genetic variants contributing interval baseline identified genome wide association studies predict individual response multiple drugs genetic analysis subjects performed secondary analysis randomized double blind placebo controlled crossover trial drugs time matched plasma drug concentration measurements subjects received single doses placebo outcome correlation genetic score comprising common genetic variants slope individual subjects drug induced increase heart rate corrected versus drug concentration results genetic score correlated drug induced prolongation among white subjects genetic score explained variability response confidence interval response confidence interval response confidence interval furthermore genetic score significant predictor drug induced independent sample cases compared controls conclusions demonstrate genetic score comprising common genetic variants explains significant proportion variability drug induced prolongation significant predictor drug induced findings highlight opportunity recent genetic discoveries improve individualized risk benefit assessment pharmacological therapies replication findings larger samples needed precisely estimate variance explained establish individual variants drive effects
anterior inferior cerebellar artery extremely rare accounting intracranial average age patients suffering found literature years significant difference sexes manifest clinically symptoms angle signs symptoms hemorrhage nausea vomiting headache gold standard exam diagnosis cerebral angiography treatment lesions controversial main difficulty surgical treatment location lies close critical structures article describe proximal without occlusion parent artery excellent results postoperative period
cold climates cycling important issue engineering cycles translocation water ice caused thermodynamic conditions temperatures just degrees changes engineering properties soils previous studies changes physical chemical mechanical properties soils investigated study compressive tests performed investigate effect cycles strength properties soil reinforced geotextile layer soil reinforced geotextile layer located mid height sample laboratory subjected maximum closed system cycles computerized tomography images also taken samples found investigated soil compressive strength unreinforced soil decreased increasing number cycles whereas reinforced samples showed better performance strength reduction amount decreased reinforcing soil images shown free water moved soil particles toward lower part soil samples addition found sample reinforcement reduce effect cycles changes cohesion resilient modulus soil elsevier rights reserved
objectivesto characterize abnormalities dorsal hand determine importance findings rheumatoid arthritis methodsa retrospective cross sectional study done patients rheumatoid arthritis hands mode power doppler joint activity scored examined mode changes power doppler signals mode changes included fluid around tissue around tissue tendon thickening around tendon power doppler signals recorded one hands joints reviewed fluid around power doppler signals observed respectively patients mode power doppler scores upper respectively mode power doppler scores categories created reported percentage patients power doppler mode scores category severity associated fluid around power doppler signals according test common odds ratio confidence interval fluid around severe common odds ratio confidence interval power doppler signals severe dorsal fluid around tissue around power doppler signals tendon thickening patients fluid power doppler signals found severe disease activity joints based mode power doppler scores
increased availability consumer grade virtual reality head mounted displays created significant demand affordable reliable input devices used control user interfaces accurate positioning users body within virtual environment essential order provide users convincing interactive experiences existing full body motion tracking systems academia industry suffered problems occlusion accumulated sensor error often lacking absolute tracking paper describes wireless sensor array system uses multiple inertial measurement units calculating complete pose users body system errors using magnetic sensor data sensor array system augmented tracking system consists rotary laser base station based tracked object users base station horizontal vertical laser lines across environment sequence known configuration position orientation tracked object determined high accuracy low latency low computational overhead shown sensor fusion algorithms used result full body tracking system applied wide variety applications interfaces
first step quantum measurement procedure known correlation established system measurement apparatus correlation classical nature one compelling correlation useful resource various quantum information theoretic protocols quantifying amount generated quantum measurement therefore seeks importance practical ground central issue present paper interestingly two level quantum system obtain amount measured term negativity generated process quantified two factors information quantifies uncertainty measurement observable conserved quantity system parameter systems initial state
rapid expansion variable renewable energy wind solar make difficult balance electricity supply demand grid scale much attention focused risk unexpected generation periods supply greater demand also present challenges lead financial losses utilities consumers renewable energy unique form occurs hydro dominated systems although hydropower thought offer highly flexible resource complement variable renewable energy seasonal variability presence environmental regulations create complex conditions renewable energy study integrated hydro economic model developed assess frequency severity financial losses arising pacific northwest hydro dominated system rapidly growing wind power generation present value losses years evaluated several future scenarios including increased wind capacity electricity price uncertainty expanded transmission capacity moving excess electricity export markets results indicate losses increase function installed wind capacity extent increase sensitive future electricity prices case adding transmission capacity alleviate losses cost infrastructure substantially associated reduction losses therefore difficult justify elsevier ltd rights reserved
antigen specific immune diseases rheumatoid arthritis often accompanied pain previous studies demonstrated gamma receptor type expressed subpopulation rat dorsal root ganglion neurons directly activated igg immune complex igg study investigated whether neuronal contributes antigen specific pain naive rheumatoid arthritis model rats vitro calcium imaging whole cell patch clamp recordings neurons revealed small medium large sized neurons responded igg accordingly vivo electrophysiological recordings showed injection igg peripheral receptive field type sensory neurons action potential discharges pain related behavioral tests showed injection igg dose dependently produced mechanical thermal rats behavioral effects alleviated localized administration non specific igg antibody mast cell histamine antagonist rat model antigen induced arthritis produced methylated bovine serum albumin found upregulated exclusively small sized neurons vitro calcium imaging revealed significantly small sized neurons responded igg rats although significant difference control rats magnitude calcium changes neurons moreover vivo electrophysiological recordings showed neurons rats exhibited greater incidence action potential discharges stronger responses mechanical stimuli igg injected receptive fields results suggest expressed peripheral directly activated igg contribute antigen specific pain pathological conditions elsevier inc rights reserved
introduction post menopausal phase characterized decline serum progesterone levels phase also associated higher incidence peripheral neuropathy aim explore relationship peripheral motor nerve status serum progesterone levels assessment motor nerve conduction velocity post menopausal women peripheral neuropathy materials methods cross sectional study conducted medical college study included post menopausal women peripheral neuropathy age post menopausal women without peripheral neuropathy control age compared median common nerves serum levels progesterone estimated enzyme study relationship hormone levels stepwise linear regression analysis done results post menopausal women peripheral neuropathy significantly lower serum progesterone levels compared control subjects stepwise linear regression analysis showed main effect conclusion findings present study suggest post menopausal age group greater risk peripheral neuropathy decline serum estrogen levels critical development peripheral neuropathy
background bone marrow derived mesenchymal stromal cells mscs cells high constitutive level autophagy low expression certain conditions mscs develop properties however transformation induced conditions largely unknown recently identified association main participant cellular stress response tumorigenesis preliminary observations revealed upregulation proteins stressed long term cultured mscs hypothesized implicated stress induced mechanisms cellular transformation mscs hence investigated effects prolonged stress mscs role autophagy survival methods human reverse transcriptase overexpressing mscs primary bone marrow stromal cells used investigate influence long term serum deprivation hypoxia growth differentiation mscs cell proliferation apoptosis evaluated using flow cytometry differentiation capabilities mscs assessed immunohistochemical staining followed microscopic examination expression analyzed using flow cytometry western blotting reverse transcriptase polymerase chain reaction autophagy explored specific inhibitors using cell morphology examination western blotting results chronic stress factors able change morphology mscs inhibit spontaneous differentiation lineage furthermore elevation downregulation accompanied defective autophagy usually associated tumor formation found inhibition autophagy promoted cell modulated expression level whereas incorporation recombinant protein cells suppressed autophagy conclusions obtained results provide model chronic stress induced transformation mscs via therefore highly relevant mesenchymal tumorigenesis
colour indicator appears green immersed skin friendly washing agents around red immersed washing solutions traffic light colour change helps parents elderly people avoid allergic reactions caused alkaline personal care products operates fully thus used multiple times without dye chemistry covalently fabric testing according product class contact high stability used proper choice skin care products general dermatology applications
paper presents economical accelerating mode including four ordered phases pure electrical driving engagement engine start engine active charging engine driving fit alternating conditions improve fuel economy hybrid electric bus typical city bus driving scenarios utilizing fast response feature electric motor adaptive controller designed realize power demand pure electrical driving mode engine starting mode engine active charging mode concurrently issue induced sequential mode transitions solved coordinated control logic engine simulation experimental results show proposed accelerating mode control methods effective improving fuel economy ensure fast transition operation modes elsevier ltd rights reserved
background pharmacy access emergency contraception involve men pregnancy prevention objectives assess availability cost study design male visited three neighborhoods new york city asked cost noted hours results twenty two created barriers get cost higher higher socioeconomic status ses neighborhood higher ses neighborhood greater number hours conclusions overall males probability able access national dialogue include males elsevier inc rights reserved
latent heat energy storage system one promising solutions efficient way storing excess thermal energy low consumption periods one challenges latent heat storage systems proper selection phase change materials targeted applications compared organic inorganic drawbacks corrosion potential phase separation however available techniques overcome minimize drawbacks hand inorganic found higher thermal conductivity storage capacity organic result inorganic great potential thermal energy storage field especially medium high temperature applications organic viable option study detailed review research outcomes recent technological advancements field inorganic phase change materials presented focusing providing solutions associated disadvantages class long term stability thermal cycling performance heat transfer enhancements also discussed context review
functional connectivity architecture adult human brain enables complex cognitive processes exhibits remarkably complex structure shared across individuals beginning understand heterogeneous structure ranging strongly hierarchical organization sensorimotor areas widely distributed networks areas frontal cortex study relied functional magnetic resonance imaging fmri data fetuses detectable morphological abnormalities adapting functional magnetic resonance acquisition motion correction signal reduction procedures resting state functional data analysis fetuses extracted neural activity information major cortical subcortical structures resting fmri networks observed increasing regional functional connectivity gestational weeks network based statistical inference approach overall connectivity network short range connections showed expansion curve contrast long range connections exhibited linear increase periods development region specific increase functional signal followed sequence occipital peak temporal peak frontal peak parietal expansion peak successfully adapted functional neuroimaging image post processing approaches correlate scale activations fetal brain gestational age vivo study reflects fact mid fetal period hosts events cause architecture brain circuitry mature presumably manifests increasing strength functional macro connectivity
patients suspected hereditary renal cell cancer referred genetic evaluation characterizing prevalence characteristics suspected inherited crucial step toward advancing personalized genetically based cancer risk management patients families evaluate prevalence characteristics suspected inherited syndromes based consensus criteria performed cross sectional analysis patients diagnosis institutional cancer registry consensus criteria referral patients genetic evaluation american college medical genetics genomics national society genetic applied two cohorts associations meeting referral criteria demographic characteristics assessed chi square tests overall cohort institutional cohort met referral criteria genetic counseling white patients commonly met early onset clear cell criteria black patients met criteria twice rate whites cohorts many individuals meet referral criteria genetic evaluation based newly emerging guidelines differences pathology noted race prospective genetic testing studies utilizing emerging referral guidelines help refine genetic spectrum inherited kidney cancer study supports efforts increase awareness referral patients genetic counseling particularly among providers
three year field experiment conducted determine integrating different applied influence yield water use efficiency corn cultivated plastic covered rainwater harvesting system semi arid chinas plateau effect treatments combination compared conventional flat control applied treatments none bare liquid film biodegradable film thick layer corn thick plastic film corn either side plastic covered plots treatments though soil moisture measured samples taken locations plot intervals depth years soil moisture storage depth significantly higher indicating likely reduced soil evaporation losses suggesting integrated systems potential increase crop sustainability region
background dcs potential danger risk alike dcs also potential side effect altitude chamber training present long training occurs literature review shows altitude chamber induced dcs approximately incidence case report old active duty military member developed symptoms dcs chamber training unfortunately seek treatment dcs exposure initial treatment included ground level oxygen therapy min oxygen per minute using mask achieved complete symptom resolution returned duty however initial flight medicine evaluation patient returned right temporal headache fatigue treated chamber complete resolution symptoms returned status later return symptoms discussion chamber familiarity training requirement military personnel allow assess ability identify symptoms hypoxia training method costly maintain also places chamber risk potential long term side effects failed treatment dcs presenting case recurrent dcs symptoms initial ground level oxygen therapy
estrogen withdrawal following menopause results increase osteoclasts formation bone resorption one important mechanisms postmenopausal osteoporosis recently growing evidence suggested receptor interacting protein implicated estrogen regulated metabolic disease including fat metabolism lipid metabolism however little known regarding role receptor interacting protein regulation bone metabolic estrogen present study western blotting disclosed estrogen brings significant increasing expression receptor interacting protein osteoclasts osteoblasts bone marrow mesenchymal stem cells furthermore analysis trap staining bone resorption assay showed depletion receptor interacting protein significantly alleviate inhibitory effects estrogen osteoclasts formation bone resorption activity moreover estrogen induce osteoclasts apoptosis increasing receptor interacting protein expression fas pathway taken together receptor interacting protein critical player estrogen mediated bone resorption
addition buffering plants water stress severe plant water storage alters many features spatio temporal dynamics water movement soil plant system impacts water dynamics drought resilience explored using multi layer porous media model model numerically soil plant hydrodynamics coupling leaf level gas exchange soil root interfacial layers novel features model considerations coordinated relationship aperture variation whole system hydraulics effects nocturnal night hydraulic redistribution soil model results suggest daytime usage night generate residual water potential gradient night along plant vascular system night represents non negligible competing sink strength significance considering occurrence usage single extended dry wide range plant attributes environmental soil conditions selected enhance suppress plant drought resilience discussed compared model calculations suggest increased root water influx plant conducting tissues maintains favorable water status leaf thereby delaying onset drought stress
one ways making high quality making consumption final asphalt mixture higher quality order use aim study study polymer order modify properties polymer modified characteristics lack modification led procedural failures caused heat regions obviously characteristics modification cause produce higher quality order use pavement tropical regions producing kind maintenance costs reduced research attempted various methods remove drawbacks technical assessment evaluate effect polymer properties include two types tests tests asphalt tests research comparison effects polymer amount penetration density degree also asphalt examined since currently challenging perfectly achieve expected polymer modified properties time compromised recommendations given paper among greatly enhancing properties high cost significantly reducing cost relatively poor properties combinations rights reserved
background multiple sclerosis allergies considered related immune responses previous studies evaluating relationship allergies provide conflicting results objective assess allergies asthma risk factors predictors relapses pediatric cohort methods environment genetic risk factors pediatric study national case control project participating sites environmental questionnaire used includes history allergies first five years life case control data entered pediatric network database cases sites enter relapse data prospectively relapse rate calculated patients follow adjusted age disease onset gender race ethnicity use disease modifying therapy results included cases mean age disease onset years female controls relapse data available cases difference prevalence allergies asthma cases controls patients food allergies fewer relapses compared patients without food allergies conclusions allergies asthma associated pediatric cases food allergies fewer relapses compared without food allergies elsevier rights reserved
arts combines intrinsically creative materials common robotics components custom programming environment teacher professional development create flexible robotics intervention secondary school classrooms order engage students robotics programs arts oriented support creation collaborative expression focused robots opposed commonly implemented competitive task focused robot activities specifically arts targets integration traditional classes literature history reach broader base students enrolled elective technology programs paper describes three classroom implementations including secondary school project including arts core courses expose diverse students engineering education activities hands experiences computer programming prototyping engineering design process present outcomes grouped within two primary themes first technological fluency present students self reporting concepts learned confidence technology breaking technology stereotypes second complementary non technical skills present skills students learned participating arts program
water crisis one challenges worldwide clean water ultimate need human life earth present study continuous adsorption experiments carried adsorption column survey efficiency carbon nanotubes removal pollutants water wastewater terms physicochemical parameters electrical conductivity total dissolved solids chemical oxygen demand cod total organic carbon using single walled carbon nanotubes multi walled carbon nanotubes sample solutions allowed flow flow mode fixed bed column showed reduction efficiency electrical conductivity effluent treatment plant treated water sample raw effluent sample synthetic salt water sample similarly efficiency reduction raw effluent sample treated water sample synthetic salt water sample cod also reduced raw effluent sample treated water sample case column showed reduction efficiency treated water sample raw effluent sample findings suggested present great potential removal pollutants terms physicochemical parameters water wastewater
evolution manufacturing technology definitive indicator human development wheels started world machines revolutionized manufacturing processes manufacturing tools indicative development paper focused branch engineering deals manufacturing specifically structure india study investigate government institutes respect manufacturing engineering education also included technical education model different education level
mammals nucleus hypothalamus site main circadian clock synchronized light dark cycle generates behavioral rhythms like feeding drinking activity main role clock control circadian rhythms questioned due presence clock activity many brain areas including implicated regulation feeding reward moreover whether circadian rhythms particular motivated behaviors exist unknown evaluated spontaneous daily circadian behavior consumption sweet caloric solution sucrose effects sucrose intake expression clock genes mouse brain mice showed daily light dark cycle circadian constant conditions rhythm intake sucrose preference rise parameters night subjective night addition observed changes circadian day night expression clock gene cortex striatum animals sucrose compared control mice pure water finally daily rhythms sucrose intake preference abolished double mutant animals data indicate expression circadian rhythms feeding behaviors controlled brain circadian per gene expression ibro published elsevier ltd rights reserved
compact model amorphous zinc oxide thin film transistors suitable cad simulators proposed model simple symmetric accurately accounts subthreshold linear saturation regimes via unique formulation accounts trapped free charges means multiple trapping release conduction band aim paper work analytic expression current terminal charges along surface potential electric field function position channel availability surface potential electric field key model advanced physical effects example carrier injection electrodes channel
research indicates affect influences whether people focus categorical behavioral information impression formation one explanation affect confers value cognitive accessible given situation three studies tested mood effects hypothesis predicting happy maintain inhibit dominant thinking styles participants completed impression formation task included categorical behavioral information consistent proposed hypothesis fixed relation mood processing emerged whether happy led judgments reflecting category level behavior level information depended whether participants led focus immediate psychological state current affective experience studies physical environment unexpected study consistent research socially situated cognition results demonstrate affective state trigger entirely different thinking styles depending context
representing digital objects structured meshes coarse block decomposition relevant problem applications like computer animation physically based simulation computer aided design cad one key ingredients produce coarse block structures achieve good alignment mesh block paper improve based pipeline produce surface volumetric coarse block structured meshes general shapes aim add new step pipeline goal optimize positions produce coarse possible base complexes rely mapping positions integer grid using integer numerical programming reach optimal best knowledge first attempt solve problem directly space previous methods generation specifically address issue corner optimization strategy efficient requires negligible extra running time pipeline paper show optimized produce block structured surface volumetric meshes compared previous approaches also induce higher quality meshes better suited spline fitting reduce number necessary cover domain thus improving efficiency overall level throughout volume
food drug administration approval ruxolitinib treatment myelofibrosis polycythemia vera changed management patients myeloproliferative neoplasms yet impact therapy risk thrombosis major cause morbidity mortality among patients remains unknown aim study evaluate impact ruxolitinib risk thrombosis among patients polycythemia vera myelofibrosis following identification randomized controlled trials comparing ruxolitinib standard care placebo rates thrombosis including venous arterial thrombosis analyzed using fixed effects models rates thrombosis significantly lower among patients treated ruxolitinib risk ratio confidence interval subgroup analysis venous arterial thrombosis demonstrated similar risk ratios reach statistical significance risk ratio respectively conclusion analysis suggests inhibition ruxolitinib decreases risk arterial venous thrombosis patients polycythemia vera myelofibrosis findings require confirmation prospective study copyright wolters kluwer health inc rights reserved
paper highlights essential schema therapy basic concepts early maladaptive schemas domains emotional core needs mode model present overview important features schema therapy look special therapeutic relationship work thereby focusing emotional processes needs oriented work age appropriate psycho education schema coaching parents clinical recommendations given based recent evidence
background mean age patients chronic hepatitis virus hcv infection usa increasing despite increasing proportion hcv infected elderly patients group represented clinical trials hcv treatment aim aimed describe real world effectiveness direct acting among elderly patients patients methods retrospectively identified hcv infected patients started treatment based regimens veterans healthcare system january june ascertained sustained response rates patients aged years older performed multivariable logistic regression determine whether age predicted results overall unadjusted rates confidence interval patients aged years older unadjusted rates similar age groups genotype treatment regimen stage liver disease treatment experience multivariate models age predictive adjusting confounders conclusion produce high rates age groups including patients oldest age category years advanced age considered barrier initiating treatment copyright wolters kluwer health inc rights reserved
present paper discusses endoscopic diagnosis treatment years demand services growing driven partly aging population popularity screening along better genetic fecal markers allow used much efficiently patients really need innovations reduction pressure patients decreasing diameter electron particularly continued parallel development research capsule endoscopy measure issues regarding perform screening test medical expenses established contrast highly precise imaging techniques progressing important theme endoscopic medicine prevalence development therapeutic endoscopy situation gastroesophageal reflux disease obesity luminal stenosis endoscopic dissection early gastrointestinal cancer endoscopic natural endoscopic surgery pancreatic diseases addition field gastrointestinal endoscopy need evolve one digestive health sciences new multidisciplinary specialty required department digestive diseases integrating specialists field
aims objectivesto explore describe parents preterm sick infants neonatal care perceive sleep experience many stressful situations newborn infant preterm sick affects bonding developing family centred care units single family rooms parents given opportunity stay care newborn infant day lack sleep affect new parents ability cope many challenges face daily basis study inductive exploratory design structured interviews conducted twelve parents infants neonatal care january march describe variations perception phenomenon data analysed using descriptive categories identified within phenomenon sleep parents preterm sick infants neonatal care impact stress sleep environment affects sleep keeping family together improves sleep parents manage prevent uncertainty negative influence sleep decreased continuous information guidance practical support skin skin care perceived stress reducing factor improved relaxation sleep encouraged nurse parents also mentioned importance together private place take care newborn infant improved sleep also desirable involve older siblings order decrease feelings sadness isolation relevance clinical parental sleep neonatal care help families cope situation facilitate problem solving emotional regulation transition
beta dehydrogenase type beta mediates glucocorticoid activation currently considered therapeutic target treat metabolic diseases however biomarkers assess activity vivo still lacking recent vitro experiments suggested human beta secondary bile acid acid acid minor amounts acid provide evidence vitro vivo studies major role beta compare level metabolism several species hepatic microsomes liver specific beta deficient mice devoid activity importantly circulating levels conjugate significantly elevated mouse models beta deficiency moreover comparative enzymology beta dependent revealed guinea pig enzyme devoid activity unlike species glycine conjugate major bile acids guinea pigs conclusion conjugated metabolites catalyzed beta lack activity leads accumulation bile acids guinea pigs beta deficient mice thus conjugates serve biomarkers impaired beta activity
computer aided materials design increasingly importance interest conventional approach solely relying experimentation longer viable within constraint available resources approach emerged first approach calculation phase thermodynamic properties complex multi component multi phase systems recent years applied broader field materials science engineering beyond phase diagrams coating joining phase transformation approach therefore plays important role modern materials design framework integrated computational materials engineering study present modeling approach integrates thermodynamic calculation kinetic simulation simulate precipitation kinetics multi component alloys applications demonstrated studies number nickel based alloys
simple method aid design digital power switching converter presented simple equations feasible designs determined depending characteristics converter sampling frequency time delay restrictions allows carry sensitivity analysis different parameters obtaining assessment influence system performance
introduction multifunctional endogenous peptides shown human rat tissues serum alpha level decreased coronary artery disease lack alpha enhances coronary atherosclerosis hypothyroidism chronic inflammatory disease high risk developing cardiovascular disease aimed search relationship overt hypothyroidism subclinical hypothyroidism alpha inflammatory markers also effect thyroxine treatment findings material methods patients overt hypothyroidism taking thyroxine treatment patients subclinical hypothyroidism without treatment healthy patients control group included study serum alpha tnf alpha glucose insulin lipid levels tested groups results evaluated spss statistical analysis method results hdl mean values statistically significantly different groups hdl level statistically significantly higher control group compared treatment group level higher level lower treatment non treatment hypothyroidism groups compared control group treatment non treatment hypothyroidism groups compared statistically significant difference hdl level high insulin level low statistically significant treatment group conclusions alpha shown protective coronary artery disease hypertension found significantly low hypothyroidism thus marker increases cardiovascular disease risk specific patient group
last decade keyword search relational databases extensively studied promises allow users lacking knowledge structured query languages unaware database schema query database intuitive way existing works keyword search databases proposed many approaches gain remarkable results however approaches designed centralized setting keyword search processed single server reality scale databases increases sharply centralized methods hardly handle keyword queries large databases moreover processing keyword search relational databases time consuming task efficiency existing centralized approaches degrade notably single server provide enough computation power keyword search large databases address challenges propose distributed keyword search approach mapreduce approach deployed cluster servers deal keyword search large databases parallel way
claimed passive fourth fundamental circuit element four decades later physical realization presents behavior resulted significant interest continuing increase growing rate provide new possibilities analog circuit design thanks properties older passive circuit elements since practically available exist market yet obtaining practical implementation behaves like important point view real world circuit design paper ultra low voltage ultra low power based design presented ultra low voltage ultra low power operational amplifier ultra low voltage ultra low power multiplier also designed use implementation design composed two type active blocks using cmos process technology symmetric supply voltages used second order key band pass filter topology designed based key band pass filter used real data processing simulation results show design adjustable provides tunable filter parameters without significant distortion appropriate parameter set even ultra low power levels low frequencies
age estimation face images important yet difficult task computer vision main difficulty lies design aging features remain discriminative spite large facial appearance variations meanwhile due difficulty collecting labeling datasets contain sufficient samples possible ages age distributions benchmark datasets often makes problem challenge work try solve difficulties means mainstream deep learning techniques specifically use convolutional neural network learn discriminative aging features raw face images without combat sample imbalance problem propose novel cumulative hidden layer supervised point wise cumulative signal cumulative hidden layer model indirectly using faces ages thus alleviate sample imbalance problem order learn effective aging features propose comparative ranking layer supervised pair wise comparative signal comparative ranking layer facilitates aging feature learning improves performance main age estimation task addition since one face included many different training pairs make full use limited training data noted two novel layers model end end extensive experiments two largest benchmark datasets show deep age estimation model gains notable advantage accuracy compared existing methods
widespread lung cancer screening low dose computed tomography urgently needed europe identify lung cancers early reduce lung cancer deaths effective method identifying high risk individuals screening determined present pilot study investigated direct families way identifying high risk individuals screening smoking cessation program avoided selection bias voluntary screening families province italy contacted telephone homes asked family members years heavy smokers pack years persons meeting criteria contacted asked participate program agreed given undergo screening receive smoking cessation counseling among contacted families involving persons eligible screening participated program cost recruitment strategy pilot study around per screened subject obtained useful information proportion general population eligible lung cancer screening proportion responded however cost home telephone calling probably high method high risk persons screening alternative recruitment methods possibly involving family physicians practitioners need investigated elsevier ireland ltd rights reserved
type positive modulators receptor enhance cholinergic activation preserving spatiotemporal features synaptic transmission receptors characteristic rapid desensitization kinetics receptor agonists shown promise improving cognition schizophrenia longer term trials therefore type evaluated safety preliminary evidence neurocognitive effect healthy human subjects single dose oral administration doses conducted double blind placebo controlled phase trial non smokers trial found indication positive non significant effects two doses produced overlapping peak levels also evidence effects inhibition auditory evoked potential repeated stimuli biomarker responds receptor activation pharmacokinetic characteristics consistent subjects safety concerns effects safety profile also assessed cohort smokers concurrent nicotine administration alter either effects safety trial demonstrates type safely administered humans potential positive neurocognitive effects central nervous system cns disorders
gender rheumatoid arthritis comprehensive project aimed studying gender differences patients differences impact patient outcomes now reporting data seventy patients gender cross evaluated following protocol univariate multivariate analyses focused different gender associated comorbidity profiles impact quality life disability patients assessed modified health assessment questionnaire respectively groups comparable regarding main demographic clinical features different comorbidity profiles found genders higher frequencies diabetes mellitus ischemic heart disease smoking chronic obstructive pulmonary disease among men depression osteoporosis among women lower women men sub scales mental health general health physical functioning physical summary component multivariate analysis indicated independent association depression osteoporosis rather gender depression women present significantly worse disability qol outcomes men differences explained female gender associated comorbidities depression osteoporosis rather gender per
introduction clinical characteristics treatment outcomes patients hereditary angioedema normal inhibitor hae inh limited methods retrospectively analyzed data french hae patients enrolled outcome survey registry july september compare disease characteristics effectiveness safety acute treated angioedema attacks patients hae inh hae inh deficiency type dysfunction type results one center contributed patients hae inh family history hae centers across france contributed patients hae type seven patients hae type patients hae inh compared hae type respectively likely female older median age disease onset years years greater rate abdominal laryngeal attacks effective groups though median time resolution attack significantly longer hae inh group attacks versus hae type group attacks self administered attacks patients hae inh patients hae type serious adverse side effects related reported conclusions data help define disease characteristics hae inh french population extend limited data reporting safe effective use acute treatment angioedema french patients diagnosed hae inh
agricultural environmental pollution china recent years chemical pollution issues become prominent favorable sustainable development chinas economy paper reports current status development utilization efficiency pesticides chemical fertilizer plastic film total power agricultural machinery moreover comparative analysis input chemical factors agricultural cultivation china horizontal vertical perspectives presented data analysis model used evaluate comprehensively utilization efficiency factor results indicate inputs chemical pollutants agricultural cultivation china differed greatly among regions inputs increased annually usage amounts pesticides chemical fertilizer plastic film chemical pollutants exhibited lower growth rate total power consumed agricultural machinery utilization efficiencies chemical pollutants generally low regions non effective efficiency decreasing returns scale
products important references cultural codes behavioral patterns related various issues society products relate topics notions social life approaches education social gender issues tendencies paradigms governance applications authority particular topic among phenomenon communication communication acts therefore scanned clues explaining communication phenomena socially approved proposed communication acts starting essential aim study phenomena turkish explore explicit hidden messaging related acts sense study significant contribution formation map semantics turkish society respect turkish language association certain words conducted thematic analysis found relation found many exerted importance verbal communication relation attributes implications many exhibited nonverbal communication acts like listening hand visual communication featured messages proposed people judged appearance
study suspensions rigid particles viscous fluid different values particle volume fractions direct numerical simulations performed using direct forcing immersed boundary method account dispersed phase combined soft sphere collision model corrections short range particle particle particle wall interactions respect single phase flow show flows drag reduced turbulent fluctuations attenuated particular turbulence activity decreases lower values obtained accounting effective suspension viscosity explain observed drag reduction consider particle dynamics interactions particles turbulent velocity field show particle wall layer previously observed found responsible increased dissipation suspensions spheres case particles significantly slower spheres near wall tend stay major axes parallel wall leads decrease reynolds stresses turbulence production overall drag reduction
preserve structure integrity graphene enhance dispersion compatibility matrix attention researchers graphene polymer nanocomposite field paper ammonium chloride kind ionic liquids first used non covalently graphene process graphene oxide reduction modified graphene incorporated poly alcohol matrix solution casting technique fabricate composites structure properties obtained investigated ray diffraction analysis xrd ray photoelectron spectroscopy xps transmission electron microscope tem atomic force microscopy raman test results showed graphene successfully modified ionic interaction structure integrity graphene reserved non covalently approach furthermore reduction process hydroxyl groups introduced virtue intrinsic properties fabricated composites exhibit considerable enhancements mechanical properties remarkable improvements thermal stability enhancement electrical conductivity low loading simple modification approach gives new opportunity improve performances graphene polymer composites wiley periodicals inc appl sci
growing body literature marks feminist ethics care within framework understand transitions primary secondary school education challenging care less especially disabled children exploring narratives parents professionals investigate transitions self identity meaningful transition depends care full spaces pupils education narratives context academic attainment culture testing examinations parents professionals children also surveyed care full education processes remain impacting disabled childrens transition secondary school healthy identity construction moreover educational challenges addressed life chances increasingly limited caring work enables engagement meaningful education positive identity formation school home care full spaces key process
first impressions made photographs faces depend much characteristics image within person variability consistent properties face person depicted person variability examine two important sources within person variability emotional expression viewpoint find within person variability person variability social impressions key traits trustworthiness dominance attractiveness index main dimensions theoretical models facial impressions important source variability emotional expression face viewpoint also affects impressions modulates effects expression example faces look trustworthy happy expression facing compared facing elsewhere whereas opposite true anger findings highlight integration different sources variability social impression formation
missense variants dna mismatch repair genes pose problem clinical genetics long assigned cause syndrome study variants uncertain clinical significance developed functional assay based direct measurement activity mouse embryonic stem cells expressing mutant protein endogenous alleles applied protocol specific mutant removes terminal amino acids found suspected families show stability severely perturbed causing attenuated vitro assays cancer predisposition mice mutation therefore considered deleterious causative
study explains design implementation virtual reality framework based interactive programming instruction engineering education courses students continue face several difficulties learning programming lack efficient tools overcome difficulties affect students motivation time creates drastic negative impact attitude towards learning programming undesirable student success engineering education suitable approach motivate students needs developed change students towards learning programming student motivation considered imperative directly influences students towards objective rather viewing programming courses means complete requirements students made realize power programming learning gaining experience computer programming necessarily involves development computational critical thinking problem solving skills skills students simultaneously opening multiple job prospects upon end facilitate interactive learning research employs learner centric user friendly virtual environment teach programming concepts research aims make paradigm shift approach teaching learning programming
mutant hypothyroid mouse models recently shown thyroid hormone critical skeletal development important growth period additionally thyroid hormone negatively regulates total body fat consistent established effects thyroid hormone energy fat metabolism since bone marrow mesenchymal stromal cells differentiate adipocytes osteoblasts relationship bone marrow predicted hypothesized thyroid hormone deficiency postnatal growth period increases marrow adiposity mice marrow adiposity deficient mice treated receptor beta specific agonist vehicle control evaluated via dual energy ray absorptiometry micro computed tomography examine mechanism thyroid hormone regulation marrow adiposity used real time pcr measure effects thyroid hormone differentiation markers primary mouse bone marrow mesenchymal stromal cells two mouse cell lines vitro mice vivo marrow adiposity increased mice weeks age treatment serum thyroid hormone normally increases day rescued phenotype furthermore rescued phenotype equally suggesting thyroid hormone effect part mediated via beta signaling treatment bone marrow mesenchymal stromal cells significantly increased expression several brown fat markers moreover injection increased specific markers white fat mice data suggest thyroid hormone regulation marrow adiposity mediated least part via activation beta signaling
purpose resilience stressful life events increase risk psychopathology influenced genetic factors purpose paper map overlap risk factors resilience onto broad psychopathological map resilience defined difference twins total score broad measure internalizing symptoms predicted score based cumulative exposure methods performed quantify overlap genetic environmental risk factors resilience four phenotypes major depression generalized anxiety disorder alcohol abuse dependence antisocial personality disorder aspd results genetic factors influence resilience account heritability respectively aspd respectively latent genetic contribution shared resilience estimate lower shared environmental covariance nominal conclusions genetic influences resilience contribute internalizing phenotypes higher degree externalizing phenotypes environmental influences also enduring effect resilience however virtually covariance resilience phenotypes genetic
year old adolescent boy presented atypical major depressive episode without specific focal neurological signs months diagnosis intracranial atypical symptoms operation however relapse atypical months first surgery mood binge eating symptoms intractable body weight gain partially improved treatment manifestations depression atypical features especially binge eating symptoms male children adolescents early onset age family history prolonged depressive episodes clinicians consider mood disorders including bipolar spectrum disorders also organic brain lesions intracranial
aim investigate effect proliferation migration apoptosis human retinal epithelium cells light injured model expression apoptosis related molecules methods human cell line exposed blue light establish light injured model cells transfected sirna knockdown expression subsequent expression determined real time polymerase chain reaction western blot respectively changes cell proliferation migration apoptosis assessed cell counting kit transwell assay flow cytometry respectively changes mrna protein levels bax caspase bcl expression results highly expressed cells blue light irradiation knockdown expression inhibited proliferation migration apoptosis blue light irradiated cells bax caspase expression significantly reduced mrna protein levels sirna treatment bcl expression significantly increased blue light irradiated cells sirna interference conclusion inhibit proliferation migration apoptosis cells light injured model moreover suppression blue light irradiated cells ameliorate cell apoptosis regulation bax caspase regulation bcl expression
promising suicide gene therapy system treat reported kinase tomato combined analog pro drug known blood brain barrier transduction found efficiently increase sensitivity human cells rats intracranial shown significantly improved survival treated system show paper strong suicidal effect together explained reduced mediated feedback inhibition phosphorylation
paper considers feedback cellular neural network cnn obtained elementary cells ideal capacitor ideal flux controlled supposed analogue computation cnn behave dynamic elements dynamic cnn cell described second order differential system state variables given capacitor voltage flux proposed networks called using dynamic giving foundation cnn model paper establishes fundamental result complete stability convergence solutions toward equilibrium points cnn symmetric presence dynamic cnn displays peculiar basically different dynamic properties respect standard first cnn computes time evolution fluxes instead capacitor voltages standard cnn furthermore steady state reached keep memory result computation limiting values fluxes currents voltages currents voltages power cnn instead standard currents voltages power drop steady state reached copyright john wiley sons ltd
objectivethe objective evaluate body movement oriented intervention aggression regulation specifically aimed towards reducing anger internalization patients eating disorder randomized treatment usual tau plus intervention tau intervention delivered therapist tau consisted multidisciplinary day treatment per week anger coping self expression control scale eating pathology eating disorder examination self report questionnaire measured baseline follow differences pre intervention post intervention scores tested using repeated measures anova resultsthe intervention group showed significantly larger decrease anger internalization control group groups showed significant reduction eating pathology differences groups significant body movement oriented therapy seems viable add treating anger internalization patients eating disorder copyright john wiley sons ltd eating disorders association
study present new theory partitioning disease prevalence incidence based mortality demonstrate theory practically works analyses medicare data theory prevalence disease incidence based mortality modeled terms disease incidence survival diagnosis supplemented information disease prevalence initial age year available dataset partitioning trends prevalence mortality calculated minimal assumptions resulting expressions components trends given continuous functions data estimator consistent stable developed methodology applied data type diabetes using individual records nationally representative sample medicare beneficiaries age numerical estimates show excellent concordance empirical estimates theoretical predictions evaluated partitioning model showed prevalence mortality increase time primary driving factors observed prevalence increase improved survival increased prevalence age increase diabetes related mortality driven increased prevalence trends time periods age groups outside range data used study finally properties new estimator possible statistical uncertainties future practical applications methodology epidemiology public health health forecasting discussed elsevier inc rights reserved
positive credit history rating help consumers good payment history get lower interest rates greater flexibility credit longer payment terms order establish credit profiles need get information spending patterns consumers companies related goods problem share private information customers companies without compromising confidentiality information work propose cryptographic protocol share sensitive information preserving privacy customer information commercial institution furthermore analyse proposed protocol using nets verify absence anomalies protocol
image enhancement edge preserving relevant steps classification techniques remote sensing images however array systems able simultaneously capture several low resolution images area different wavelengths forming high spatial spectral resolution image raising series new challenges paper open computing language based parallel implementation approach presented near real time enhancement based bayesian maximum entropy edge preserving algorithm remote sensing imagery uses local linear unbiased risk estimate selected results synthetic aperture radar image enhancement whereas shown better noise removal properties commonly used methods within context image processing methods adapted via parallel computing techniques efficiently implemented using cpus commodity graphics processing units gpus experimental results demonstrate reduction computational load real world image processing near real time gpu adapted implementation
aim computational molecular design identification promising hypothetical molecules predefined set desired properties address issue accelerating material discovery state art machine learning techniques method involves two different types prediction forward backward predictions objective forward prediction create set machine learning models various properties given molecule inverting trained forward models bayes law derive posterior distribution backward prediction conditioned desired property requirement exploring high probability regions posterior sequential monte carlo technique molecules exhibit desired properties computationally created one major difficulty computational creation molecules exclusion occurrence chemically unfavorable structures circumvent issue derive chemical language model commonly occurring patterns chemical fragments natural language processing strings existing compounds follow chemical language backward prediction trained language model used refine chemical strings properties resulting structures fall within desired property region chemically unfavorable structures successfully removed present method demonstrated design small organic molecules property requirements gap internal energy package available repository
digital three dimensional imaging technique lower radiation dose computed tomography due missing data systems structures depth direction completely removed reconstruction algorithms work analyzed impulse responses common systems plane plane basis proposed fast accurate based add model simulate images addition analysis formalism describing impulse response plane structures generalized rotating parallel implemented ray tracing forward projection ray based model algorithm based model simulate shift add reconstructions based model proper geometry distortion correction provides reasonably accurate estimates reconstruction numerical comparison indicates simulated images using two models differ less terms root mean squared error based model used efficient system geometry analysis reconstruction algorithm design plane artifacts suppression registration
paper presents methodology modeling repetitive construction projects introducing modeling procedure based system model simulator aim developing intelligent tool facilitate decision making construction implementation phase study offers conceptualization construction processes designed monolithic construction computer aided system enables flexible approach managing repetitive projects within dynamically changing construction environment discussion deals art modeling construction process introduces repetitive construction process formulated dynamic construction process model temporal perspective construction process representation three coordinate system managing assumed goals module designed simulate process behavior create execution strategies models capable handling variability construction process execution address complexity relations among production system components including resource mutual constraints case study discussed involves execution construction processes means slip system exhibits large degree repetition therefore particularly useful example illustrating effectiveness modeling approach proposed original contribution research lies representing construction process specificity deriving nature repetitive projects technological regime developing flexible structures enable construction process complexity addressed iii designing representation construction process within system model simulator developed significant outcome overall study development system capable harnessing cyclic nature repetitive processes converting vital asset construction management elsevier rights reserved
importance dietary fibre fractions animal feeding due influence rate passage mucosal functionality role substrate gut microbiota relates performance digestive health complexity physical structure chemical composition plant cell walls explains wide different physiological effects large range fibre fractions review first briefly consider definition structure different classes fibres cell wall constituents followed description analytical methods employed second nutritional role impact fibre intake digestive health described growing rabbit extensive analysis previous studies performed without antibiotics fibres rabbit feed essential reducing risk digestive weaning requirements defined terms quantity quality fibre fractions follows minimal dietary level balanced maximum quantity fibres ratio soluble fibres defined difference total dietary fibre quickly digested rabbit however impact digestive health still questioned
multiple reports context time taken read joint effects stimulus quality word frequency interact words appear list additive words triple interaction explained terms idea different processing modes play different contexts processing cascaded words appear list allowing effect stimulus quality influence downstream process affected word frequency contrast appear list early process affected stimulus quality word frequency reduce probability reading word stimulus quality low present experiment addresses issue whether presence driven included stimulus set participants read words varied word frequency randomly identical words brain stimulus quality word frequency additive effects time read context consistent view matters aspects results suggest level feed back play particular kind used
hereditary angioedema hae rare disabling sometimes life threatening aim study describe prevalence symptomatology treatment sweden total patients identified adults children hae type giving minimum hae prevalence patients received written questionnaire followed structured telephone interview report focuses adults responded females reported attacks previous year males females reported days sick leave days males treated acute attacks plasma derived inhibitor concentrate used patients good effect maintenance treatment used attenuated androgens used reduced attack rate conclusion minimum hae prevalence sweden hae affected females severely attenuated androgens good effect preventing attacks
global warming climate change increased frequency heavy precipitation heavy rainfall results large amount water entering within short time period water remains pavement system certain time period reduces strengths granular bases induces pavement geotextiles commonly used drainage purposes require soil saturation however soil saturation always exist enable gravity drainage water conventional geotextiles geotextile new type woven geotextile recently introduced market remove moisture unsaturated soils geotextile includes special hydrophilic deep fibers cross sections induce high capillary force water soil without saturation soil ability rate geotextile remove water soil depends several factors including temperature relative humidity study series laboratory tests controlled temperature relative humidity conducted quantify water removal rate geotextile half length geotextile submerged water tanks half outside tanks water tank geotextile air tests conducted different test conditions different temperatures relative test results demonstrated geotextile remove water water tank certain rate three commonly used methods available literature adopted quantify water removal rate geotextile based vapor pressure temperature relative humidity new concept equivalent water evaporation length geotextile proposed study pointed tests presented paper aimed determine maximum water removal capacity geotextile given sufficient water supply american society civil engineers
often occur individuals relationship swimming pools exists however little research investigated relationship swimming pools study sought examine prevalence among swimming pool employees population risk infections samples taken employees swimming pools area microscopy culture used identify fungi swimming pool employees concurrent compared controls respectively adjusting age gender swimming pool employees likely concurrent likely likely compared controls present results agreement previous research support swimming pools remain important source fungal contamination attention guidelines preventative measures needed settings
objective compare bladder sensitivity patients pelvic pain patients pain free undergoing noninvasive controlled bladder via also sought measure potential mechanisms underlying bladder sensitivity design prospective observational study setting community teaching hospital population reproductive age women non bladder chronic pelvic pain painful bladder syndrome pelvic pain free controls methods participants compared capacity pelvic floor pressure pain thresholds pelvic muscle function bladder questionnaire psychosocial instruments using wilcoxon rank sum tests multivariate regression used identify factors underlying bladder pain phenotypes main outcome measures pelvic floor pain thresholds self reported bladder pain results participants exhibited higher bladder pain groups reporting higher pain levels controls significant associations found bladder pain pelvic muscle structure pain sensitivity measures however bladder pain positively correlates vaginal adjacent bladder pain bladder pain maximal less influenced somatic sensitivity bladder symptoms versus multivariate regression identified three independent components bladder symptoms bladder pain bladder sensation somatic symptoms conclusions induced bladder pain experimental bladder pain predicted pelvic floor sensitivity compared patient reported outcomes appears less influenced psychological factors study needed determine whether screening experimental bladder pain sensitivity predict future risk
introduction last years diet experimentally utilized various childhood neurologic disorders alternating childhood brain tumors migraine autism spectrum disorder asd aim review analyze target different medical conditions highlighting possible mechanisms covered conducted analysis literature concerning use brain tumors migraine commentary role reducing seizure activity efficacy pyruvate dehydrogenase deficiency known recently cases suggest decreasing paroxysmal activity children affected data support potential use adjuvant alternative therapeutic option brain cancer beneficial effect migraine remains unclear improve cognitive social skills subset children asd
real time rendering high precision using digital terrain models input data challenging task especially targeted level detail data structures utilized tackle huge amount data paper present real time rendering approach computation hard using large scale digital terrain data obtained satellite imagery approach based extended horizon mapping algorithm avoids costly pre computations ensures high accuracy algorithm developed handle large data proposed algorithms take surface curvature large spherical bodies account computation performance issues discussed results presented generated images exploited research aerospace related areas graphics
consumption high fat diet overweight induce functional deterioration atrophy hippocampus alterations associated mental disorders depression anxiety exercise obesity enhances brain health substantial evidence neuronal nitric oxide synthase key regulator affective behavior increased brain leads anxiety environmental enrichment reduces brain effects study investigated effects without exercise protein gene expression levels brains mice twelve weeks consumption increased body fat weight protein levels hippocampus cerebral cortex six weeks exercise training reduced body fat rescued hippocampal cortical expression levels fed mice cerebellar expression unaffected exercise results suggest induced brain dysfunction regulated hippocampal cortical exercise therapeutic potential treatment induced depression anxiety via pathway conclusion exercise induced changes hippocampal cortical protein levels mice elsevier inc rights reserved
optimal sustainable public transport infrastructure project portfolio selection requires environment management strategy social economic development study considers application multi criteria decision making methodology applied assess sustainable development transport infrastructure projects taking account range transport social financial environmental criteria furthermore order resolve strategic decision making resource constraints carbon footprint factor zero one goal programming model developed facilitate optimal portfolio sustainable public transport infrastructure projects taiwan resulting data shows perspective transport criterion decreasing traffic energy consumption significant evaluation factors light rail project project comprise far optimal portfolio sustainable transport infrastructure projects strengthen connection activity based abc evaluation carbon footprint life cycle assessment integrated approach practical useful tool providing solution related information sustainable public transport infrastructure projects help managers incorporate environment costs decision making processes elsevier ltd rights reserved
study new state space representation protein folding problem use reinforcement learning methods proposed existing studies way defining state action space prevents agent learn state space amino acid sequence rather defined state action space valid particular amino acid sequence moreover existing methods size state space strictly depends amino acid sequence length newly proposed state action space reduces dependency allows agent find optimal fold sequence certain length additionally utilizing ant based reinforcement learning algorithm ant algorithm optimum fold protein found rapidly compared standard learning algorithm experiments showed new state action space ant based reinforcement learning method much suited protein folding problem two dimensional lattice model elsevier rights reserved
oscillation test methodology effective detecting physical defects open bridging defects low voltage cmos analog mixed signal circuits paper discusses low voltage two stage operational amplifier using cmos technology high fault coverage minimum area overhead five bridging faults one open fault detected discrete practical extensive simulations based cmos technology parameters using pspice test technique presented circuits ensures high fault coverage requires negligible area overhead
aims determine value retention determining bile acid diarrhoea bad treatment response predictors positive retrospective review consecutive patients undergoing including gender age history clinical laboratory parameters included diseases associated type bad resection crohns disease type bad chi squared test logistic regression determined factors predictive bad subjective response treatment bile acid analysed respect patients male average age years ninety five patients investigated type bad type patients type idiopathic bad large increase number performed time difference percentage positive tests one hundred seventy nine patients bad positive result commonest possible type severe bad ninety nine patients severe bad retention moderate bad retention mild bad retention predictors positive right crohns positive predicted good partial response mild moderate severe bad conclusion test use increased high positive results throughout resection crohns independently predict bad predicted response
current usage term hybrid electric power referring electrical networks installed offshore marine assets refers coupling energy transformation systems utilize different technologies exchange energy electrical network composed energy transformation device necessary energy converter utilized match electrical characteristics electrical network converter facilitates exchange energy electrical network required rate also known source capable supplying net positive energy electrical network consumption loads energy exchange electrical network unidirectional directional directional energy exchange implies energy absorption capability energy absorption manifest economically energy storage capability manifest ability energy energy storage capability operate unidirectional include traditional generators utilizing combustion based diesel engine gas turbine steam turbine prime alternate fuel cells primary batteries also energy storage capability unidirectional wind turbine generators solar energy energy storage capability commonly understand directional include secondary batteries capacitors hybrid electric power systems offer opportunity improve safety reliability operational efficiency reduce fuel rate environmental footprint maintenance costs compared traditional electrical power systems
improving yield strength asymmetry critical expand applications magnesium alloys industry higher fuel efficiency lower production grain refinement efficient method strengthening low symmetry magnesium alloys achievable refinement study provides guidance engineering improve mechanical properties grain refinement refinement improving yield strengths asymmetry simulated quantitatively coupling stochastic second phase grain refinement model modified crystal model using stochastic second phase grain refinement model grain size quantitatively determined size volume fraction yield strengths yield asymmetry deformation behavior calculated modified model shape size remain constant grain size decreases increasing volume fraction volume fraction kept constant grain size decreases decreasing size refinement yield strengths increase asymmetry one decreasing grain size contributed increasing volume fraction decreasing size
protecting control planes networking hardware high rate packets critical issue networks operation one common approach conventional networking hardware expensive functions onto hard engines approach inadequate networks certain amount flexibility network control tries provide therefore need control plane protection mechanism switches last preserving flexibility network control paper propose mechanism filter packet messages include packets handled control plane networks without important ones network control switches record values packet fields sending packet messages filter packets values recorded ones controllers set fields advance whose values recorded fields selected based controller design implemented evaluated proposed mechanism prototype software switch dramatically reduces cpu loads switches passes important packet messages network control
menopause increased prevalence metabolic syndrome mets central obesity seems increase hot inflammatory secreted visceral fat investigated levels relationship hot flash number bmi postmenopausal women mets also evaluated effect effective reducing levels year treatment randomized double blind placebo controlled trial postmenopausal women mets randomly assigned receive placebo daily year main outcome measures hot number circulating levels evaluated significantly correlated bmi number women mets basal months results indicate strong correlation significant effect reducing women mets present study suggests plays role symptoms least postmenopausal women metabolic syndrome reduce decreasing circulating levels inflammatory
magnetorheological fluid type smart material control mechanical properties magnetic field iron particles fluid form chain structures direction applied magnetic field known effect resulting variation stiffness shear modulus damping characteristics fluid effect depends density particles fluid strength magnetic field experiments conducted evaluate friction property motion changing types fluid strength magnetic field material aluminum steel chosen specimen common material mechanical applications surfaces specimen also observed optical microscope experiments compare surfaces test conditions comparing results show friction coefficient increases strength magnetic field increases regardless types fluid material also density particle fluid affects friction characteristic results research used improve performance mechanical applications using fluid
last years two new cardiovascular drug classes namely inhibitors developed cases clinical evidence potential induce angioedema known already blockers angiotensin system majority angioedema induced inhibitors occurs concomitant treatment therefore likely mediated bradykinin type receptors striking contrast molecular pathways causing angioedema induced inhibitors unclear although contribution bradykinin appears likely nevertheless clinical evidence suggesting inhibition relieve symptoms prevent invasive treatment including angioedema caused drugs therefore risk angioedema always considered especially ambulatory care situations patients rapid access intensive care
reinforced soil foundations employed engineering practice increase soil bearing capacity reduce potential settlement aim study develop analytical solutions estimating ultimate bearing capacity strip general failure mode first proposed based previous studies conducted authors test results literature study limit equilibrium stability analysis performed based proposed failure mechanism new bearing capacity formulas consider membrane effects increase ultimate bearing capacity developed strip several special cases presented discussed proposed model verified experimental data reported published literature predicted ultimate bearing capacity good results model tests reported literature study showed depth shear failure zone depends relative strength reinforced soil layer underlying unreinforced soil layer directly related reinforced ratio japanese geotechnical society production hosting elsevier rights reserved
background crohns disease chronic disabling condition curative medical treatment current treatments provide increasingly sustainable control disease allow patients better quality life limited evidence supporting management specific clinical situations thus evidence based approach aims help clinicians making informed treatment decisions group french experience management met develop straightforward practical algorithms based european crohns colitis organisation recommendations methods experts opinion developed following nominal group consensus methodology nine clinical situations identified active moderately active without poor prognostic factors severely active single complex without complicated intestinal post operative two working groups formed proposed algorithms approved two thirds majority nominal group results algorithms represent pragmatic consensus group experts modalities therapeutic care different clinical situations available via web application published elsevier ltd rights reserved
single issue online mobilization wake social media significant ground covered regarding changing possibilities mobilization question specific circumstances condition political impact online mobilization public received much less attention last couple years increasingly employed facebook public noteworthy results single issue separated issues concerned paper explores single potential trivial political issue new building developed project supported nearly public issue failed political project paper actor network theory account trajectory issue translated along way actors built concepts structures opportunity structures framing processes employed light conditions possibilities emergence development impact building finally paper discusses social impact image engaged power relations citizens discussion paramount importance heritage constructing
due rapid developments research areas medical imaging medical image processing robotics computer assisted interventions becoming integral part modern patient care software engineering point view systems highly complex research benefit greatly software components supported number open source medical imaging medical imaging interaction toolkit public software library ultrasound imaging research plus independent inter toolkit communication open image guided therapy link used combine advantages enable easier realization clinical workflow presented network interface within allows easy use asynchronous two way messaging clinical devices performance interoperability tests carried considering whole workflow data acquisition processing visualization present applied different usage scenarios performance tests tracking data transmitted frame rate latency transmission images typical ultrasound high definition resolutions possible respectively integration protocol now supported established open source field interoperability plus facilitates cross toolkit research collaborations provided open source style http
saving power becomes one main objectives information technology industry research companies consume lot money shape power consuming virtual desktop infrastructure new shape delivering operating systems remotely operating systems executing cloud data center users applications accessed using thin client devices thin client device consisting screen attached small cpu benefits terms cost reduction energy saving paper increase power saved system without save least energy consumption users companies integrating computing systems using power efficiency saving improved save improving increasing energy saving features also illustrated experiment integrated system increase percentage energy saved
hybrid electric vehicles offer potential fuel consumption improvements compared conventional vehicle fuel consumption benefits utilising hybrid electric vehicle architecture dependent much braking energy regenerated regenerated energy utilised number power management strategies proposed literature owing prospect real time implementation many proposals centred use heuristics despite research advances made key challenge heuristic strategies remains achieving reasonable fuel savings without state charge end trip view challenge paper offers two main contributions existing energy management literature first novel simple effective heuristic control strategy employs parameter percentage maximum motor power decide control sequence impressive fuel savings achieved without final state charge battery battery energy second quantitative exploration braking patterns impact kinetic energy regeneration potential proposed heuristic control strategy explored range driving cycles reflect different driving scenarios results analysis show fuel savings much achieved japan driving cycle comparison suboptimal controller whose control signals derived dynamic programming optimal control proposed strategy found achieved impressive real time fuel savings without much penalty final state charge battery braking patterns also found significantly improve brake energy regeneration electric motor
review projects countries provides starting point series experiments degrees vertical pressure kpa examine short term development strains affect longer term performance gravel sand gravel sand caused significant excessive strains conditions examined shape grading curve much greater effect potential magnitude strains just maximum particle size six granular examined best performance graded sand offered sufficient support minimize strains due inducing significant strains directly nevertheless even case maximum strain almost double maximum recommended literature ensuring good long term performance consideration composite clay shows foundation larger strains induced given specific conditions examined shown apparent improvement performance versus tested geotextile protection layer also found insufficient prevent significant strains due examined elsevier ltd rights reserved
violent media consumption often thought lead aggression violence especially social cognitive theories assume pivotal role cognitive functions normative beliefs explanation human behaviour including violence see violent media possible potent learning environment although many studies analysed relationship violent media consumption violence longitudinal apparently study analysed mediator effects violence normative beliefs data western country two points time researchers assume violent media consumption already existing disposition violence due experiences parental maltreatment double dose effect described moderator effect assumptions mediation moderation tested structural equation models using cross sectional longitudinal data german panel study results show interaction effects parental behaviour violent media consumption surprisingly weak whereas influence approval violence remarkable extent mediated eventually smaller extent violent behaviour
nonverbal behavior plays important role human human interaction teaching inherently social activity exception far effect nonverbal behavioral cues accompanying lecture delivery investigated case traditional lectures students teachers located however becoming increasingly frequent lectures online new type setting still unclear effect nonverbal communication article tries address problem proposes experiments performed lectures popular web repository results show automatically extracted nonverbal behavioral cues voice quality activity predict ratings users assign presentations
contact activation system system older recognized biochemical pathways include several proteins blood coagulation complement angiotensin fields proteins initially proposed part pathways deficiencies associated prolonged clinical assays however absence bleeding states deficiencies factor high molecular weight indicates contribute since discovery factor years ago much learned biochemistry cell biology animal physiology proteins surface defense mechanism foreign proteins organisms artificial materials inflammatory response mechanism targeting activation plasma inhibition blood interacts artificial surfaces modern interventional medicine acute attacks hereditary angioedema vascular homeostasis products arise deficiency also offer novel ways reduce arterial venous thrombosis without effect summary interest due better understanding activities new appreciation systems lead several new therapies variety medical disorders
investigate whether long term chronic treatment inhibitor affects adrenal testicular diabetic men using liquid chromatography tandem mass spectrometry longitudinal prospective started randomized placebo controlled double blind clinical trial carried male patients affected type diabetes mellitus diagnosed within last years total patients followed year assigned study placebo group respectively progesterone testosterone sulfate cortisol evaluated using liquid chromatography tandem mass spectrometry differences seen sex testicular steroids study control group adrenal gland steroids considered according produced significant differences seen steroid produced significantly decreased treatment study group higher levels visit visits sulfate ratio significantly increased treatment group considering adrenal significantly changed among visits groups higher levels visit complete clinical instrumental examination performed visits according study protocol chronically administered reduces levels increases sulfate ratio possible consequences modulation enzymes tissue changes cyclic adenosine cyclic availability possibly stress related increase suggested first time
overt sexual prejudice declining report little prejudice still subtle biases gay men examined implicit prejudice sample heterosexual college students reported little sexual prejudice using affect procedure amp measures affect skin conductance heart rate facial responses recorded participants viewed photos mixed sex couples rated valence arousal sexual prejudice evident implicit amp ratings explicit ratings valence responses results suggest implicit prejudice young adults endorse low levels sexual prejudice cognitively emotionally based unlike fear based reactions commonly described racism limitations future directions research discussed
objective paper design controller able control output angle upper limb robotic arm precision motion high speed response aim optimize best controller upper limb robotic arm system precision motion motion results injuries loss production manufacturing system research robotic arm prototype degree freedom dof designed fabricated motor implemented studies carried based previous research investigate suitable type controller pid controller fuzzy logic controller chosen compared terms performances steady state error settling time rise time overshoot used micro box motor motor driver circuit micro box module acts interface hardware component matlab open loop simulations carried obtain transfer function motor substituted system simulation analysis simulation system carried observe close loop system characteristic without controller close loop point point trajectory control simulations experiments carried compensated systems using pid controller based frequency response method analyses made based results obtained best type controller chosen achieving precise motion control upper limb robotic arm paper pid controller shows better performances compared fuzzy logic controller steady state error less settling time input reference respectively
paper examines whether indigenous peoples right reproductive autonomy established right self determination health international human rights law extent reproductive health rights effectively protected government sponsored population policies historically instances government population policies targeting specifically primarily indigenous peoples includes programmes removal children live foster white families recent years family planning programme past decade seen important developments field particular australian governments important generation proposal state generations compensation adopted provide measure past policies global level number important initiatives population policies developed recent second international conference population development paper argues right self determination health prior informed consent includes right self government autonomy also include indigenous right reject government policies subject communities birth control programmes
background various online applications service led development online health communities addition peer peer communication offer patients users also interaction health professionals benefits challenges patients users participation extensively studied thorough examination health professionals moderators provide clinical expertise patients users experience participation lacking objective aim study explore main benefits challenges health professional moderators participation methods study exploratory qualitative study depth semi structured interviews health professional moderators participating largest net data analysed using inductive thematic analysis approach principles grounded theory results four themes health professional moderators experiences identified benefits addressing users health related needs challenges addressing users health related needs health professional moderators benefits health professional moderators challenges conclusions small study demonstrates health professional participating moderators perceive facilitators patients users empowering processes outcomes users improve health literacy develop skills expand social support gain important resources necessary dealing health related issues health professional moderators role however also involves several responsibilities limitations often experienced difficulties providing patients users adequate counselling online medical service also represent important terrain personal professional empowerment health professional moderators although presence processes also needs noted elsevier ireland ltd rights reserved
particle image velocimetry planar laser induced fluorescence techniques used measure flow special attention given understanding details flow role enhancing mixing process comparisons three explained providing detailed measurements several axial cross planes enhance mixing two streams generating additional pair small scale observed shear layer test condition inner flow mixing duct occurs downstream decay cross velocity starts exit plane initial magnitude rise decay
japanese engineering launched first time utilize observations investigations particularly improve accuracy low degree gravitational harmonics gravity field near limb measured combined doppler measurements enable three dimensional information extracted differential radio sources called experiment involves two board sub satellites observed using differential measure trajectories satellites japanese network named vera exploration radio international network use multi frequency method measure angular distance two sub satellite radio sources observations three frequencies band mhz one band mhz method uses low power consumption carrier waves suitable positioning japanese domestic network vera conduct observations whole mission period one year addition conduct two periods intensive observations one month duration also include international stations shanghai china australia germany observations measure phase delay accuracy better band baseline length equivalent positioning accuracy combining data tracking satellites main different attitudes four way doppler measurements making long term observations sub satellites excess one year without able improve accuracy gravitational field known order magnitude completed development board instruments carrying pre flight tests variety conditions also undertaken test observations smart international network published elsevier ltd rights reserved
systemic fungal infection caused fungus individuals usually self limiting localized disease whereas immunocompromised individuals develop disseminated disease occurrence progressive disseminated juvenile systemic lupus erythematosus extremely rare one reported case literature showing association therefore report case severe opportunistic fungal infection caused year old girl diagnosed juvenile lupus erythematosus subsequently developed septic shock died disease despite aggressive antifungal therapy
aim study investigate overall root shoot allocation metal contaminants amount metal removal absorption adsorption within external root surfaces dose response water metal uptake examined single metal trial using arsenic gold copper iron zinc iron also used low medium high concentration treatments test dose effect water metal uptake water generally tolerant except total amount metals removed accumulated roots onto root surfaces furthermore total metal assimilation water located roots factor exceeded recommended index used selection plants nevertheless increased increase concentration water suggests use index alone without consideration plant biomass metal concentration water inadequate determine potential plants accurately thus study confirms water holds potential broad spectrum roles however knowing whether metals within plant tissues knowing allocation roots shoots inform decisions treat biomass metal recovery mode biomass reduction safe disposal
displays represent one attractive next generation display applications therefore critical analyze effects mechanical stress amorphous thin film transistors order apply displays display applications dynamic mechanical stress tests designed carried using bending radius less paper dynamic mechanical bending stress tests performed using various bending directions order examine instability characteristics addition degradation mechanisms investigated using technology computer aided design simulation result demonstrated now possible establish reliable circuit guidelines using display applications
recently research cultural groups gradually becomes new focus study disabled culture typical example going perspective paper mainly summarizes influence physical appearance interpersonal space distance etc disabled peoples communication analyzes cultural foundations based theory value orientations finally communication principles proposed purpose improve communication disabled people
hereditary angioedema hae rare disorder resulting decreased functional levels inhibitor inh manifests periodic episodes localized edema extremely painful debilitating even fatal swelling affects hae complicate many aspects obstetric care awareness disease critical clinicians involved care women potential hae related complications pertaining pregnancy labor delivery womens health issues article provides review published literature specific hae management female patients including important concerns regarding obstetric care growing body relevant experience presented help guide care women hae
ambient intelligence aml worlds consist heterogeneous collections interconnected devices integrate environment offer services users devices added change fail modifying system topology also circumstances change affecting users activities time location presence users changes modify information system available satisfy users needs context aml systems need adapt evolving conditions order able provide services possible users also performance requirements system fulfill provide responses environment stimuli real time opportunistic control mechanisms address issues monitoring context resolving goals appropriate conditions met paper presents software framework supports development aml applications facilities context management rely opportunistic control development systems uses simulator tool testing validation called case study installation illustrates use infrastructure elsevier ltd rights reserved
chromatin immunoprecipitation chip indispensable tool fields epigenetics gene regulation isolates specific protein dna interactions chip coupled high throughput sequencing chip seq commonly used determine genomic location proteins interact chromatin however chip seq hampered relatively low mapping resolution several hundred base pairs high background signal chip method refined version chip seq substantially improves upon resolution noise key distinction chip methodology incorporation lambda digestion library preparation workflow effectively footprint left right dna protein dna site chip libraries subjected high throughput sequencing resulting data provide unique ultra high resolution insights functional organization genome describe chip method optimized mammalian systems next generation sequencing synthesis platform
psoriatic skin integrity altered lead insufficient integrin interactions leaving integrin exposed possibly accessible production therefore investigated presence anti integrin autoantibodies serum patients psoriasis vulgaris psoriatic arthritis psa rheumatoid arthritis comparison healthy donors level circulating anti integrin antibodies determined enzyme linked immunoassay using integrin fragments antibodies least one recombinant fragment found approximately psa patients contrast patients frequency antibodies similar healthy controls study shows presence anti integrin antibodies psa indicate ongoing abnormal processes skin anti integrin autoantibodies contribute formation micro wounds skin characteristic wound healing phenotype psoriasis
mood disorder patients need due increased pain sensitivity recent studies suggested anti inflammatory drugs nsaids inhibit antidepressant treatment requires replication clinical recommendations methodsthe clinical health outcomes initiatives comparative effectiveness bipolar disorder study randomized participants months lithium treatment use nsaids assessed throughout study period psychopathology measured clinical global impression scale bipolar disorder bipolar inventory symptoms scale effects nsaids treatment outcome examined using mixed effects linear regression adjusted age gender body mass index smoking status exercise somatic diseases participants used nsaids study users differ respect treatment outcome lithium time point months treatment overall subscales depression mania users nsaids users nsaids showed statistical difference compared first trial show use nsaids alone combination affect lithium based bipolar disorder mood stabilizing treatment outcomes prior studies suggested nsaids inhibit antidepressant treatment whereas results support findings indicating detrimental effects nsaids affective disorder treatment
feeding interactions among functional feeding groups robust indicators aquatic ecosystem interactions provide information regarding organic matter processing habitat condition trophic dynamics tropical rivers pronounced wet dry seasons based ecological monitoring tools explicitly focused metrics indices ignoring interactions therefore objective study investigate functional feeding type metrics diversity indices feeding interactions among along water pollution gradient watershed ethiopia water quality parameters community attributes assessed samples collected upstream sites sites urban impacted sites wetland affected river zones sites watershed rainy july dry february seasons understand effect pollution feeding interactions stable carbon nitrogen analyzed based diversity indices functional feeding type metric showed deterioration ecological integrity urban impacted sites substantial recovery wetland affected downstream sites feeding behavior noted upstream sites whereas clear trophic suggested wetland affected river zones stable isotope results results pollution gradient analysis feeding interactions among revealed urban impacted sites showed weaker interactions compared upstream wetland influenced sites potential importance feeding interactions among water quality monitoring elsevier gmbh rights reserved
forensic tools assist recovery data system events even storage tools typically rely file techniques restore files metadata loss analyzing remaining raw file content significant amount sensitive data stored processed relational databases thus creating need database forensic tools extend file solutions database raw database storage partitioned individual pages read presented without help database furthermore directly accessing raw database storage reveal things normally hidden database users exists number database specific tools developed emergency database recovery though usually forensic analysis database paper present universal tool seamlessly supports many different databases table data content remaining storage fragments disk memory define approach automatically minimal user intervention reverse engineering storage new databases detecting volatile data changes discovering user action artifacts finally empirically verify tools ability recover partially data directly internal storage different databases authors published elsevier ltd behalf open access article license http creativecommonsorg licenses
evolution procedure fitness distribution population always since varies many factors nonlinearity optimization problem crossover mutation algorithms progress evolution procedure gas using stochastic selection mechanisms fitness distribution sometimes significantly impacts performance selection process make ineffective protecting superior individuals preventing inferior individuals study new fitness scaling method named powered distance scaling proposed eliminate influence fitness distribution stochastic selection unlike previous approaches new method uses powered fitness distance substitute raw fitness values ranking numbers computing scaled fitness maintains much constant consistent selective pressure different conditions optimization problem algorithm design help designers balancing exploration exploitation evolution procedures empirical studies employed illustrate new method using new scaling technique convergence speed search becomes controllable elsevier rights reserved
human identification distance recently become hot research topic fields computer vision pattern recognition since gait patterns operate distance without subject cooperation gait recognition widely studied address problem paper subspace ensemble learning using totally corrective boosting framework kernel extension proposed gait recognition framework multiple iteratively learned different weight distributions set using totally corrective technology order preserve proximity relationships among instance extend framework kernel framework deal nonlinear manifold data compare method recently published gait recognition approaches database experimental results indicate proposed method achieves highly competitive performance state art gait recognition approaches
purpose provide examples mitochondria specific metabolic events influence tumor cell biology metabolism related mitochondrial biomarkers therapeutic targets cancer cell mitochondria optimally serve cancer cell various conditions cellular stress list mitochondrial alterations support cancer cell proliferation survival progression includes upregulation oxidative metabolism use alternative substrates increased superoxide production mutated mitochondrial dna altered mitochondrial morphology dynamics potential therapeutic targets include fatty acid oxidation voltage dependent anion channel pyruvate dehydrogenase complex complex traits example metastasis likely regulated fine tuned balance several metabolic processes events upregulated parallel also dependent cues many metabolism related mitochondrial biomarkers show prognostic value biological interpretation data overall metabolic status context understanding metabolic regulation important targeting cancer stem cells therapeutic targeting cancer cell mitochondria remains experimental promising predictive markers needed metabolism based treatments personalized medicine
objective assess effect introducing consensus guidelines blood region methods blood determined among blood transfusion recipients eight hospitals workshop senior health workers region consensus guidelines prescription blood developed introduced hospitals months intervention data collected blood transfusion recipients data compared estimate change proportion blood results blood transfusion recipients aged years significant reduction proportion blood especially peripheral hospitals children proportion decreased operated patients percentage remained pregnant women significant increase proportion blood adults improvement peripheral hospitals offset similar deterioration referral hospital thus overall reduction achieved proportion blood conclusion development introduction consensus guidelines sufficient change prescribing practice proportion blood decreased hospitals compliance maintained regular clinic meetings strict supervision senior medical staff
present method measure simultaneously using single camera method tracks motion facial features determine displacement extracts corresponding velocity acceleration taking first second temporal derivatives displacement respectively measured waveforms consistent reported literature also recorded accelerometer based reference method method also tracks based reflected light facial region makes possible track optics verify robustness reproducibility method small pilot study subjects presented method first demonstration simultaneous monitoring without wearing extra equipment marker subject
paper describes early studies results design system supporting domain experts managing data streams coming set sensors services base ambient intelligence ami environments domain experts use proposed system elaborate needs ideas type data flow generated monitoring emergency situations combining physical social sensors moreover conduct different analysis considering contextual information space time thematic
light primary signal circadian neural circuits thus coordinates daily physiological behavioral rhythms solar cues drosophila mammalian circadian circuits consist diverse populations cellular oscillators exhibit wide range dynamic light responses periods phases degrees heterogeneous circadian circuits generate robust physiological rhythms remaining flexible enough respond stimuli long remained short wavelength expressed approximately half drosophila circadian neurons previous study physiological light response measured using real time recordings drosophila whole brain explants remain intrinsically light sensitive apply analysis real time experimental data show detailed dynamic ensemble representations whole circadian circuit light single neuron resolution whole brain explants either maintained constant days exposed phase advancing light pulse second day find stronger circadian oscillators support robust overall circuit whereas weaker oscillators toward transient amplitude facilitate new state phase shifted network additionally use mathematical modeling examine network composed distinct oscillator types give rise complex dynamic signatures conditions response simulated light pulses simulations suggest complementary coupling mechanisms combination strong weak oscillators enable robust yet flexible circadian network promotes complete understanding properties oscillators signaling mechanisms facilitate distinct roles light allow direct augment circadian system speed recovery jet lag shift work seasonal affective disorder
loss dopaminergic neurons typical parkinsons disease responsible medium neurons resulting abnormal glutamatergic synaptic drive considering neuroprotective effect exercise changes promoted exercise type glutamate receptors role activity regulated cytoskeleton associated protein arc trafficking studied impact short long term exercise evolution unilateral hydroxy dopamine animal model wistar rats divided sedentary groups without lesion followed months groups subjected moderate exercise week measured proteins tyrosine hydroxylase arc striatum substantia nigra motor cortex results showed higher reduction expression sedentary groups compared groups striatum substantia nigra general larger changes occurred striatum first third months training month exercise significant increase concomitant reduction arc balanced system changes reversed third month showing increase arc decrease similar results arc observed motor cortex animals modifications relevant circuits since exercise dependent plasticity modulate expression neuronal excitability
myelofibrosis bcr negative myeloproliferative neoplasm mainly characterised reactive bone marrow fibrosis constitutional symptoms progression shortened survival malignancy still curative treatments indeed treatment clearly demonstrated impact disease progression allogeneic stem cell transplantation minority patients eligible intensive therapy however recently discovery mutations also led development small molecule inhibitors first ruxolitinib approved treatment united states europe article report old new therapeutic strategies proved effective early preclinical clinical trials subsequently daily clinical practice patients particularly concerning topics splenomegaly iron overload allogeneic stem cell transplantation
chronic medical diseases evaluated several comorbidities indexes reported influence overall survival patients syndrome mds however studies included patients lower higher risk disease study retrospectively evaluates role comorbidities evaluated mds comorbidity index mds together clinical parameters series patients mds defined either score low intermediate favorable cytogenetic categories multivariate analysis together age years diabetes requiring therapy hemoglobin incorporation comorbidities mds independently associated probability death combination variables allowed development model patients three different groups significantly different probability integrated score confirms importance comorbidities diagnosis patients mds
introduction aim study evaluate association breast cancer thyroid diseases many authors already studied possible relationship two diseases results nowadays conflicting materials methods study examining patients breast cancer women men average age years old also thyroid disease evaluated recurrence thyroid diseases association different types breast cancer statistical analyses performed using spss software windows used nonparametric tests chi square level significance set results found significant association breast cancer diagnosed menopause thyroid disease moreover analyzed role thyroid autoimmunity identifying association chronic autoimmune thyroiditis breast cancer diagnosed menopause regarding receptor profile breast carcinoma found increased expression estrogen receptors patients autoimmune thyroiditis compared patients thyroid diseases found difference group every thyroid disease group without thyroid disease find statistically significant associations breast cancers parameters like family history tumor size lymph node metastasis distant metastasis cancer clinical pathological stage differentiation grade expression two main groups without thyroid disease likewise found statistically significant association hypothyroidism hyperthyroidism breast cancer
nineteen isolated identified used ethnic medicine treating cough asthma wounds china among six compounds previously acids known compound beta beta acid obtained first time nature based traditional effects chinese potential anti inflammatory activities methanol extracts isolated evaluated tests ear swelling mice lipopolysaccharide lps induced nitric oxide production mouse macrophage cellular raw inhibition assay neutrophil respectively resulting performed obvious effect mouse ear swelling dose dependent inhibition vivo nine compounds showed significant inhibition production vitro values ranging also exhibited inhibition neutrophil vitro active substances correlated traditional efficacy elsevier ltd rights reserved
small scale fixed bed coal biomass represent attractive option distributed combined heat power generation known phenomena complex involving drying heterogeneous homogenous reactions large number intermediate final products processes also influenced reaction kinetics fluid dynamical effects temperature concentration gradients reason simulation models able predict performance assumption thermodynamic equilibrium process takes place known temperature reaction time lower residence time consequence fixed bed equilibrium models consider drying taking place lower temperature heat transfer zone solid feed heated therefore moisture involved reactions since released reaching reaction zone several models based steady state one dimensional representations developed reproduce processes fixed bed reactors models found adequate provide information engineering design process optimization framework steady state simulation model developed department mechanical chemical materials engineering university using plus computer code predicting performance small scale draft fixed bed coal model used evaluate mass energy balance zone main characteristics produced process composition mass flow temperature heating value etc paper describes model presents main results parametric analysis shows process influenced main operating parameters moreover results model compared experimental results draft fed mentioned part pilot gas treatment plant built research centre italy comparison shows model represents performance pilot scale unit elsevier ltd rights reserved
study conducted validate capability dna microarray technology gene chip detecting food borne pathogens nine types food borne pathogen used namely bacillus escherichia coli staphylococcus aureus salmonella spp spp spp total combinations dna templates food borne pathogens used polymerase chain reaction pcr southern blotting hybridization methods used gene chip validate capability results gene chip compared results gel electrophoresis five required complete combinations dna templates food borne pathogen screening one gene chip used negative control whereby dna templates food borne pathogen inoculated results showed combinations food borne pathogen dna templates detected negative control chip show presence dna study showed gene chip gave better results gel electrophoresis
paper discuss psychopathological background domain persons examination anomalous world experiences interview aims describe manifold phenomena concrete distinctive features thus abstract symptom focused approach domain persons focuses specifically experienced interpersonal disturbances especially common schizophrenia aim domain rest provide clinicians researchers systematic orientation toward knowledge patients experiences experiential schizophrenia clarified terms particular feel meaning value patient help provide context domain persons propose definition former ability understand persons basis capacity experience people social situations meaningful relies intuitive cognitive computational resources addresses core psychopathological nucleus characterizing quality abnormal persons schizophrenia covers several dimensions including disturbances intuitive cognitive computational capacities typical intuitive abnormality lack interpersonal resonance difficulties immediately understanding others mental states characteristic cognitive computational anomaly social especially algorithmic conception observational attitude aimed develop explicit often rule based personal method participating social transactions anomalous interpersonal experiences emotional behavioral responses others also discussed relation core karger basel
platform electrochemical transduction suitable point care diagnostic solutions intuitive optical read designed current electrochemical cell light emitting diode performance optimised several variants circuitry tested circuit comprising field effect transistor exhibited sought abilities absolute simplicity high sensitivity device limit detection signal eye without additional instrumentation low direct assay whole system employing consisted shelf components price reached sic even small scale experimental production system rather suitable yes applications due steep response curve alternative circuitry linear range also finally rather higher initial voltage required electrochemical cell based transducer lead design simplified variable circuit employing operational amplifier elsevier ltd rights reserved
exercise known produce strength loss disruption repeated application exercise stimuli appearance indexes muscle damage attenuated called repeated effect direct connection established repeated effect exercise induced increases protein turnover appears degree tolerance developed toward exercise present study sought investigate markers protein degradation determining expression components related ubiquitin proteasome system ups repeated exercise healthy men carried min bench stepping performing work one work leg performing duplicate exercise later control group included rna extracted muscle biopsies representing time points days selected mrna species quantified using northern blotting exercise model proved sufficient produce repeated effect terms strength box transcription factor muscle ring finger protein strong seen exclusively loading displayed strong downregulation exclusively response exercise transcription first produced downregulation persisted second conclusion ups modulated differentially response varying loading modalities different time frames way extent reflects changes protein metabolism known take place exercise
paper presents new enhanced block technique data address bandwidth transmission time issues simple block simple data method security hidden information increased increasing number stages addition stage decreases capacity increases size data needed transmit secret message thus results increase required bandwidth transmission time proposed technique addresses bandwidth transmission time issues simple method output high quality image peak signal noise ratio provides additional security simple reduces requirements bandwidth transmission time one half simple thus solves capacity issues low bandwidth channels copyright john wiley sons ltd
sleep circadian rhythms intrinsically linked several sleep traits including sleep timing duration influenced sleep homeostasis circadian phase genetic variation several circadian genes associated diurnal preference preference timing sleep although limited research whether associated sleep measurements investigated whether genetic variations associated diurnal preference questionnaire various sleep measures including global pittsburgh sleep quality index score sleep duration sleep latency sleep quality genotyped polymorphisms genes circadian expression participants sample british longitudinal population sample young adults conducted linear regressions using dominant additive recessive models inheritance test associations polymorphisms sleep measures found significant association diurnal preference polymorphism period recessive model novel significant association diurnal preference polymorphism hydrocarbon receptor nuclear like additive model found polymorphism nucleotide binding protein beta beta associated significantly global sleep quality recessive model rare polymorphism period associated significantly sleep duration quality recessive model findings suggest genes circadian expression play role regulating circadian clock sleep homeostasis highlight importance studies aimed specific roles circadian genes play two interrelated unique behaviours
purpose aim paper explain difficulties associated applying science nutrition advice protect public health using example dietary fibre design methodology approach based review relevant literature published first section traces history attempts constructing useful definitions dietary fibre problems measurement fibre content foods measurement fibre intake individuals testing correlations disease outlined findings nature current definitions dietary fibre lack accuracy validity reliability methods determination major limitations developing understanding role protecting human health perhaps dietary constituent elucidation science describing role dietary fibre human nutrition known unidentified variables practical implications paper reflects increasing scientific awareness developments nutrition subject limitations methods analysis research design explains processes scientific investigation often slow reveal important relationships dietary factors health presents difficulties authorities charged promoting health protective eating behaviours originality value although possible quantify dietary fibre effects human metabolism research provides strong support choosing wide range fresh minimally intact plant food sources protect health recommended promoted many countries around world health protective effects achieved moderation information disseminated dietary fibre particularly via marketing manufactured foods supplemented fibre isolates
sharing columns networked resistive sensor arrays simplified complexity suffered crosstalk problem among elements crosstalk mainly affected resistor adjacent column elements adjacent row elements array size first designed improved isolated drive feedback circuit using one operational amplifier reduce crosstalk caused adjacent column elements networked resistive sensor array mathematical equivalent resistance expression element tested circuit analytically derived equivalent resistance expression evaluated simulations simulation results show greatly reduce crosstalk error caused adjacent column elements networked resistive sensor array row column fashion resistance expression used general formula evaluate performance
oxidative bond cleavage non heme critical step human metabolism pathway microbial degradation pollutants catalytic cycle proposed involve formation complex although presence substrate radical called question studies related ring recently reported first synthesis iron complex coordinated ligand namely hydro radical anion derived amino current manuscript density functional theory dft calculations wide variety spectroscopic methods electronic absorption magnetic circular resonance raman employed obtain detailed electronic structure descriptions one electron oxidized derivative addition describe synthesis characterization parallel series complexes featuring neutral supporting ligand tip shifts obtained experiments confirm tip based analogue contain centers presence radical verified analysis absorption spectra light time dependent dft calculations collective spectroscopic data indicate one electron oxidation complexes yields complexes electronic configurations iii limits highlighting ability access multiple oxidation states implications results mechanism ring discussed
associated adverse human reproductive fetal developmental measures outcomes endocrine disrupting effects however biological mechanisms adverse effects exposure humans currently established study aimed identify biological pathways potential biomarkers exposure maternal umbilical cord serum using hydrophilic interaction chromatography tandem mass spectrometry metabolomics platform median concentration total maternal cord serum wet respectively levels maternal fetal serum study mother childrens health cohort comparable earlier cohort studies conducted japan usa european countries used random forest model profile predict exposure levels first quartile fourth quartile pregnant women fetuses prediction model classification versus area curve auc pregnant women fetuses add level maternal serum levels cord serum auc values candidate biomarkers metabolite included models related glutathione amino acid metabolism maternal serum amino acid metabolism biosynthesis cord serum indicating disruption metabolic pathways exposure pregnant women fetuses results showed analysis useful explore potential biomarkers related biological pathways exposure thus detailed studies needed verify sensitivity biomarkers clarify biochemical changes resulting exposure authors published elsevier ltd open access article license http creativecommonsorg licenses
patients bipolar disorder high risk developing cardiovascular diseases aging process however investigations lacking regarding risk factors specific patients aim study examine relationship traditional risk factors association characteristics older age totally recruited patients dsm least one psychiatric admission confirmed cvd diagnosis icd code mean age years case subject matched one patient without based age sex date recent psychiatric admission years clinical data obtained retrospectively reviewing medical record multiple logistic regression model showed traditional risk factor diabetes mellitus also non traditional one associated first episode mania significantly increased risk given limitation cross sectional study longitudinal investigations needed elucidate contributions traditional risk factors characteristics cvd risk patients
prevalence metabolic syndrome increasing african populations particularly high black south african women women united kingdom united states america population group also known highest prevalence obesity sub saharan african region consequently high risk non diseases article discuss factors abdominal subcutaneous fat visceral fat lean mass adiponectin leptin vitamin smoking menopausal status investigated possible association metabolic syndrome african women discuss recommendations management syndrome particular development hiv aids clinics south africa provides ideal integrated platform treatment needs patients multiple chronic morbidities
zebrafish important vertebrate model organism biomedical research especially suitable morphological screening due transparent body early development deep learning emerged dominant paradigm data analysis found number applications computer vision image analysis demonstrate potential deep learning approach accurate high throughput classification whole body zebrafish deformations plates deep learning uses raw image data input without need expert knowledge feature design optimization segmentation parameters trained deep learning classifier images data augmentation achieved classification accuracy test data set comparable previous state art based user specified segmentation deformation metrics ablation studies digitally removing whole fish parts fish images revealed classifier learned discriminative features image observed deformations head region rather visually apparent tail important good classification performance
manufactured metal components often exhibit fine dendritic microstructures elemental segregation due initial rapid subsequent melting cooling build process without adversely affect materials performance letter report situ observation kinetics nickel based using small angle ray scattering identified kinetic time scale good agreement thermodynamic diffusion simulation predictions using microstructural dimensions acquired situ scanning electron microscopy findings serve predicting observing validating treatments materials inc published elsevier ltd rights reserved
tau established microtubule associated protein neurons however pathological conditions aberrant assembly tau insoluble aggregates accompanied synaptic dysfunction neural cell death range neurodegenerative disorders collectively referred recent advances understanding multiple functions different locations tau inside outside neurons revealed novel insights importance diverse range molecular pathways including cell signalling synaptic plasticity regulation genomic stability present review describes physiological pathophysiological properties tau relate distribution functions neurons highlight post translational modifications tau pivotal defining modulating tau roles health disease include discussion relevant changes tau including mutation aggregation aspects propensity tau propagate potentially drive neuronal loss diseased brain finally describe cascade pathological events driven tau dysfunction including impaired axonal transport alterations synapse mitochondrial function activation protein response defective protein degradation important fully understand range neuronal functions attributed tau since provide vital information involvement development pathogenesis disease knowledge enable determination critical molecular pathways targeted potential therapeutic agents developed treatment
paper deals problem robust stability analysis grid connected converters filters controlled digital signal processor subject uncertain grid inductance model uncertain continuous time plant digital control gain discretization procedure described terms series expansion employed determine accurate discrete linear matrix inequality based condition proposed assess robust stability polynomial discrete time augmented system includes filter state variables states resonant controllers delay digital control implementation means lyapunov function proposed strategy main advantage provide theoretical certification stability uncertain continuous time closed loop system main disadvantages previous approaches employ approximate discretized models errors numerical simulations illustrate benefits discretization technique experimental results validate proposed approach
control ups inverters special importance applications high quality output voltage needed several control schemes proposed control three phase inverter paper presents simple powerful control scheme using model predictive control mpc uses discrete time model system predict behaviour output voltage possible switching states generated inverter cost function used selecting optimal switching state applied next sampling instant simulation results linear nonlinear loads presented using matlab simulink tools verifying feasibility good performance proposed control scheme finally experimental results presented using simulation verify feasibility good performance proposed mpc realistic conditions
nowadays web services one commonly used technologies distributed system integration interoperability recently new communication technique called web appeared implementing web services offer true server push mechanism paper present system based manage agent communications motivate use technologies use case new web message transport protocol described implementation platform presented based agent interaction use case presented along comparison web http message transport protocols
paper proposes advanced configuration power converter system traditional converter four switches replaced converter modulation algorithm converter also introduced replacement help system works many low level voltage sources output voltage flexible therefore system efficiency increases dimension battery solar panel decrease theory simulation experiment presented paper order validate configuration
previous study five different secretory proteins including calr identified associated carcinoma metastasis work proteins investigated bioinformatics analysis suggested play important role process development western blotting analysis showed targets secreted extracellular high metastatic cells non metastatic cells except expressions calr proteins extracts cells significantly different thus expressions differentially expressed proteins tested cohort tissue specimens results indicated expression levels highly correlated lymph node distant metastasis patients moreover enzyme linked immunosorbent assay elisa used investigate concentrations serum specimens patients results revealed serum expression level closely correlated lymph node metastasis clinical stage patients able discriminate metastasis non metastasis sensitivity specificity present data show first time novel potential biomarkers predicting metastasis furthermore serum potential serum tumor biomarker prognosis
background congenital heart disease chd common congenital malformations high mortality morbidity prevalence chd reported previously ranged per live births per live births cross sectional study aimed document prevalence chd district province china analyzing data collected hospitals located counties district supported public health campaign methods total consecutive month old infants included july july structural abnormalities diagnosed based echocardiography findings including two dimensional color doppler echocardiography results results infants found cardiac structural abnormalities total prevalence chd per live births value significantly higher previously reported prevalence cases per live births top five common cardiac abnormalities follows atrial defect asd cases ventricular defect cases parts per thousand patent cases parts per thousand pulmonary stenosis cases parts per thousand cases parts per thousand chd prevalence differed gender study chi majority asd cases females regional differences prevalence also found chi higher prevalence found urban areas cases per live births rural areas cases per live births significant difference prevalence chd preterm versus full term infants chi prevalence chd infants maternal aged years significantly higher chi conclusions prevalence chd district within range reported using echocardiography echocardiography used early diagnose chd
present wind tunnel study focuses effects wind barriers aerodynamic aeroelastic characteristics bridge characterized various aerodynamic shapes cross section three bridge deck sections studied semi sections standard high full scale wind barrier porosity placed leading edge bridge deck sections aerodynamic forces moment determined various wind incidence angles stability studied using quasi steady theory flutter derivatives determined evaluate flutter sensitivity studied bridge deck sections wind barrier comparison empty bridge deck sections experimental results indicate important features particular drag force coefficient increased bridge deck sections wind barrier place feature particularly exhibited bridge deck section wind barrier alters trends values lift force coefficient influence wind barrier pitch moment particularly exhibited positive wind incidence angles characteristic bridge deck sections wind barrier influence sensitivity studied bridge deck sections dynamic stability respect torsional flutter elsevier ltd rights reserved
large number energy inefficient buildings constructed without taking account principles green building requires efficient utilization local resources work fibres used order produce effective ecological thermal material tests carried using short fibres effective composites local renewable resources produced macro microstructures composites fibres shown activated allows getting ecological materials fibres fibres consist many investigations shown thermal conductivity natural fibres depends material density structure
autoimmune diseases often share common susceptibility genes genetic variants associated susceptibility systemic lupus erythematosus also associated autoimmune diseases linked variant positioned exon gene encoded protein functions regulation kappa master regulator immune response aim study investigate whether polymorphism general susceptibility factor autoimmunity evaluated case control association occurrence different autoimmune diseases including new data systemic lupus erythematosus previous genome wide association studies gwas though analyse chromosome psoriasis celiac disease crohns disease ulcerative colitis multiple sclerosis type diabetes rheumatoid arthritis ankylosing spondylitis cases patients affected amyotrophic lateral sclerosis type diabetes also included study detected nominal significant associations systemic lupus erythematosus additive model test psoriasis one two studies multiple sclerosis results suggest associated risk several autoimmune diseases european populations specifically diseases present among skin european federation immunological societies published elsevier rights reserved
smart materials emerging category multifunctional materials physical chemical properties altered response external stimulus combining standard properties advanced material unique ability recognize adapt response change environment materials finding applications areas sensing drug delivery majority materials responsive physical chemical changes particularly exciting area research seeks develop smart materials sensitive specific molecular stimuli systems require integration molecular recognition probe specific target molecule interest ease synthesis labeling low cost stability dna make uniquely suited effectively serve molecular recognition probes novel smart material systems review highlight current work area based smart materials prospects future applications
paper presents design implementation digital control system modular multilevel converters based digital signal processors achieve higher system control reliability multi functionality proposed architecture built effective split control tasks involved master controller six controllers one six arms converter master controller handles energy flow within converter user communication using universal serial bus controller handles capacitors voltages balancing within arm different boards achieved mainly optical fiber inter integrated circuit bus experiments carried verify effectiveness architecture
background fatty acids substantial components lipids cell membranes form review consists two parts present part aims describing fatty acid classification dietary sources biological functions second part focus fatty acid physiological roles applications human health disease results humans fatty acids produced due absence certain thus specific fatty acids termed essential alpha need taken diet fatty acids whose synthesis depends essential fatty acid intake include acid acid found fish dietary sources saturated fatty acids animal products tropical plant oils palm whereas sources unsaturated fatty acids vegetable oils olive soybean oils marine products algae fish oils saturated fatty acids related adverse health effects whereas unsaturated fatty acids especially polyunsaturated thought protective addition trans fatty acids shown negative effects health whereas conjugated fatty acids beneficial lastly fatty acids main components lipid classes esters non fatty acids conclusion fatty acids important take part complex metabolic pathways thus major biological roles obtained various dietary sources determine type fat consumed consequently health outcome
objective document use contraception representative sample australian women aged years compare methods women asked use contraception method used reason non use computer assisted telephone interviews women sampled random digit mobile phones participation rate results weighted sample active women interviewed using method contraception including amounts women aged using method pregnant wanted baby said partners currently intercourse past menopause apparently risk unintended pregnancy used method used oral contraceptives condoms primary method use condoms intrauterine devices implants emergency contraception increased since use method used varied age group location occupational group relationship status parity third women ever used emergency contraception highest rate among women conclusion australian women access wide range effective contraceptive methods implications given high levels use unintended pregnancies australia likely attributable method failure inconsistent use elsevier inc rights reserved
introduced contextual probability theory called default based three principles first principles states random variable automatically labelled conditions recorded aim article relate principle block structured computer programming languages variables local construct called scope constructs correspond notion condition used way variable two safely meaning label preserve two distinct identities without need label variable condition advocated means examples notion probabilistic program program introduced based semantics programs illustrated using known relational database language sql provides efficient operational semantics core issue addressed construct single probabilistic model various probability distributions returned scope purpose probabilistic variant natural join operator relational algebra used together distributions single distribution generally article attempts connect probabilistic programming means relational database theory published elsevier inc
combination large range motion insufficient bony stabilization makes joint susceptible injuries including dislocation young athletes magnetic resonance computed tomography play important role preoperative injuries paper illustrates findings acquired time subjects illustrate common causes sequelae shoulder instability teaching points equivalent full thickness tears superior evaluating defects cartilage surface lesions superior evaluating extra articular injuries
climate control applications form heating cooling account significant portion energy consumption buildings transportation consequently improved efficiency climate control systems significantly reduce energy consumption greenhouse gas emissions particular leveraging intermittent continuous sources waste heat solar energy thermally driven energy storage systems climate control play crucial role demonstrate concept battery operates storing thermal energy subsequently releasing provide heating cooling demand taking advantage adsorption desorption evaporation condensation mechanisms battery high power density energy storage system investigated battery detail identify critical parameters governing overall performance detailed computational analysis used predict cyclic performance exposed different operating conditions thermodynamic cycles addition experimental test bed constructed using contemporary material demonstrate concept deliver average heating cooling powers respectively maximum power densities specific powers observed heating cooling respectively making battery competitive art climate control systems provide relatively lower power densities additionally opportunities development innovation especially synthesizing novel materials battery achieve significantly higher power densities ability function using thermal energy input compact lightweight battery offers option address energy challenges associated rising demand climate control elsevier ltd rights reserved
smart environments growing combination various computing frameworks ubiquitous pervasive etc devices control algorithms complex web interactions core user facilitation number industrial domestic public areas basis application areas critical terms correctness reliability safety security etc achieve error free requirement compliant implementation systems designed various modeling approaches including ontology paper attempts consider correctness reliability safety security design process related components proposing design time modeling formal verification methodology proposed methodology covers various design features related modeling formal verification focusing users devices environment control algorithms interaction set requirements model checking realistic case study bank door security system tested results show successful verification properties related safety security desired reliable behavior copyright john wiley sons ltd
limited investigation volume shape difference subcortical structures children adhd paucity examination influence sex findings objective study examine morphology volume shape subcortical structures association emotion dysregulation girls boys adhd compared typically developing counterparts participants included children ages years old without dsm adhd structural magnetic resonance images obtained shape analyses conducted using large deformation metric mapping compared boys boys adhd showed reduced volumes bilateral amygdala volumetric differences structure adhd girls shape analysis revealed localized within putamen amygdala adhd boys relative boys significant correlations increased unique expansion right putamen right amygdala findings suggest sexually pattern differences subcortical structures children adhd compared children possible neurobiological mechanism boys adhd demonstrate increased difficulties
aim study explore relation mothers parenting stress functioning hypothalamic pituitary adrenal axis expressed daily salivary cortisol concentrations children diagnosed attention deficit hyperactivity disorder adhd seventy five children aged diagnosed adhd predominant impulsive combined adhd symptoms adhd healthy peers mothers participated study mothers completed measures assessing childrens adhd status perceived parenting stress parenting stress index short form psi mothers symptoms psychopathology social support socioeconomic status childrens salivary cortisol samples collected six different time points single day mothers children adhd reported higher levels parenting stress mothers children adhd controls psi subscales showed significant associations childrens cortisol response car adhd groups exception parental distress subscale adhd group adhd groups parent child dysfunctional interaction subscale difficult child subscale psi total score significantly associated childrens car revealed mothers high levels parenting stress functioning children adhd population car identified sensitive peripheral measure functioning study showed families children diagnosed adhd complex relation mothers high levels parenting stress childrens atypical hypothalamic pituitary adrenal axis functioning
purpose dose response relationship fasting blood glucose levels risk pancreatic cancer investigated association blood glucose levels pancreatic cancer death examined examined association fasting blood glucose levels death due pancreatic cancer japanese methods performed pooled analysis individual japanese including participants aged years ten cohorts participants classified five groups low normal middle normal high normal blood glucose fasting blood glucose diabetes blood glucose fasting blood glucose anti diabetic drug use low normal middle normal high normal defined according fasting normal blood glucose levels hazard ratios hrs confidence intervals cis pancreatic cancer mortality estimated fasting blood glucose cohort stratified cox proportional hazards regression analysis low normal blood glucose fasting blood glucose reference results fasting blood glucose showed dose response relationship pancreatic cancer mortality trend adjusting covariates hrs cis diabetes however significant associations blood glucose tendencies observed exclusion participants first years follow conclusions fasting blood glucose better predictor pancreatic cancer death blood glucose
study targeted employed staff specific business unit campus south african university explore relationship employees perceived levels trust immediate line manager overall perceptions diversity climate within business unit south africa recently years although racism discrimination place current widespread university suggests big enduring challenges transformation easily resolved clearly much still remains done order accelerate transformation higher education system critical question arises change brought cost effective sustainable way view steadily growing incidents often violent university therefore seems appropriate researchers evaluate far south africa really come considering extent different business units universities able contribute towards creation prejudice free inclusive society factors influence within environment similar organisations diversity climate extent university able establish academic environment free prejudice discrimination diversity climate institution reflects psychological perceptions attitudes beliefs individuals also translate different groups include limited gender age racial ethnic groups interact within specific organisational context psychological behavioural indicators diversity climate affect individual organisational performance dramatic way either positive negative nature previous research studies international arena suggest address challenge change organisations develop quality relationships inter enhanced building developing trust however easily said done especially since historical context one trust diverse groups repeatedly time despite fact effective diversity management create prejudice free inclusive workplace environments becoming growing concern empirical research diversity climate still limited even fewer studies examined possible relationship diversity climate trust fact within south african context research relationship various forms trust potential influence diversity climate organisation extremely rare study took quantitative approach explore relationship dyadic trust diversity climate cross sectional survey used collect data questionnaire used study combination three previously validated instruments diversity climate defined employees perceptions policies practices communicate extent fostering diversity eliminating discrimination priority organisation diversity climate measured previously validated diversity climate assessment instrument consisted nine items study employed definition trust widely accepted across disciplines according trust defined willingness party vulnerable actions another person based expectation perform particular action important party irrespective ability monitor control party trust multi dimensional interrelated complex concept dimensions used measure trust included predictors trust evidence actual risk taking expressed behaviours two previously validated measures trust combined order measure trust component comprehensive manner predictors included eight items measure propensity also known innate generalised inclination trust others items employed measure perceived trustworthiness derived indications trusted perceived ability items items integrity items trust also measured items confirmed indicators behaviours willingness rely items disclose information items trusted party despite lack guarantees ones trust abused prior measurement instrument translated english possible errors identified corrected independent professional three languages study results indicated majority employees perceive diversity climate positive agree organisation committed towards diversity management eliminating discrimination correlation analysis dimensions trust diversity climate revealed trust dimensions except propensity towards trust sort relationship diversity climate results indicated group employees education grade indicated higher propensity towards trust compared group either post graduate degree propensity towards trust disclosure based trust dimensions revealed noticeable differences black white groups practical significance within diversity climate construct gender education ethnic employment status level employment groups regarded positive result institution paper concluded recommendations future research
modern knowledge base systems frequently need combine collection databases different formats relational databases xml databases rule bases ontologies etc database system manage different formats knowledge reason even file systems different computers part knowledge base often necessary handle different versions knowledge base want find common parts differences two versions relational database examine use rule bases dependency rule graphs also proof trees derived atoms help compare different versions rule base moreover possible joining rules knowledge representation ontologies shown benefits many applications intelligent systems many proposals rule languages compatible semantic web stack semantic web rule language recently ontologies used hybrid systems specifying different components
linguistic databases provide quick insight stored data important facilities understanding meaning large data collections especially relevant context big data however large data collections often suffer incomplete data case relational databases modelled called null values paper propose novel soft computing technique measuring quality linguistic summary case missing information specifically describe illustrate bipolar satisfaction degrees used model validity summary validity caused due missing information extra information provides users semantically description results important view correct interpretation
chinas largest emission source power sector large scale power exchange results issue emissions transfer embodied power transmission based detailed power exchange data bottom method takes account fuel mix exported electricity developed calculate emissions embodied power transmission emissions power sector associated consumption perspective analyzed compared production based perspective calculation shows total emissions embodied power exchange accounting total emissions power sector embodied emissions general transfer pathway embodied emissions eastern china western china long range power transmission disparities consumption production based emissions significant provinces production based emissions power sector inner higher consumption based consumption based emissions beijing larger production based study also reveals increasing trend emissions production consumption principles provinces period elsevier rights reserved
emergency calls represent one routes emergency hospital admissions care homes aimed describe pattern call rates care homes identify factors predicting homes calling frequently obtained data south western service foundation trust calls relating people aged care homes region april july supplemented data care quality commission website home characteristics outcomes used descriptive statistics identify variation call rates residential nursing homes fitted negative binomial regression models determine call rates predicted home type nursing versus residential five standards reports dementia care status travel time hospital one hundred forty six homes residential nursing included analysis number calls made ranged median number iqr range calls per resident per year nursing homes lower call rate residential homes adjusted rate ratio care homes failing quality suitability management standard lower call rate compared passed homes dementia higher call rate compared findings require replication regions establish investigation required determine extent call rate variability reflects different needs resident populations differences care home policies practice
dna methylation implicated pathogenesis schizophrenia considered potential candidate schizophrenia conducted vitro dna methylation reaction luciferase activity assay assay assess dna methylation expression underlying pathophysiology schizophrenia found dna methylation putative regulatory regions attenuated luciferase activity difference dna methylation pattern patients controls data suggest dna methylation regulated expression associated schizophrenia
migration health studies traditionally focused socioeconomic determinants health emerging body literature exploring migration status cause health outcomes study path analysis predictors mental health amongst documented workers singapore shows threat one important social determinants predicted mental illness mediator impact workplace conflict mental health study qualitative study narratives workers workplace conflict demonstrates workers believed threats used strategy workplace conflicts findings suggest migration status places workers come workplace conflict heightened risk mental illness migration status used tool workplace
currently mobile devices people number likely many folds internet things revolution next years unprecedented computational power especially wide spread multicore processors mobile phones paper investigates proposes new methodology mobile cluster computing multiple mobile devices including multicore processors combined perform possibly massively parallel applications paper presents details steps building testing mobile cluster using proposed methodology proving successful implementation
purpose though commonly seen patients crohns disease also seen patients without inflammatory bowel disease purpose study evaluate imaging differences patients without crohns disease methods retrospective search january december radiology database yielded patients patients dedicated protocol studies included whereas patients previous anal surgery tumors findings assessed excluded following features assessed anatomic type classification luminal origin hour clock position anal distance signs acute inflammation circumference involved inflammation presence rectal inflammation results one hundred twenty six patients met inclusion criteria crohns disease common identified crohns non crohns crohns non crohns associated cases crohns group non crohns group rectal inflammation present patients crohns disease without crohns finding statistically significant conclusions study demonstrates groups similar imaging features accompanying rectal inflammation commonly seen crohns disease
specialized species like often develop beneficial relationships exploit ecologically constrained lifestyles although drive specialization host symbiotic relationship indicative host tested relationships highly specialized two three spp spp respectively symbiotic algae using analysis showed pattern distribution found phylogeny found support algae implying lineage algae host switching occurred spp spp results support previously hypothesized symbiotic relationship algae indicate played role algae diversification broadly convergent evolution facilitate host switching deeply host lineages elsevier inc rights reserved
objective investigate feasibility effectiveness home based exercise program individuals methods twenty three individuals divided two groups according timed score performed week home based exercise program primary outcomes exercise adherence maximum voluntary contraction lower limbs index secondary outcomes adverse effects barriers exercise practice results social functioning domain improved significantly group improved significantly physical functioning domain total adherence week home based exercise program mild moderate adverse events related exercise program adverse events related test conclusions home based exercise program feasible effective improving disability quality life individuals
paper addresses identification switched linear mimo state space systems proposed methodology explores use subspace identification techniques clustering data classification obtain estimate main contribution work lies inclusion identification step points generated mode points classification proposed use hybrid filtering technique known interacting multiple model algorithm important feature overall identification algorithm matrices different directly combined obtained state space basis efficiency developed method demonstrated via numerical examples
paper deals identification errors variables models additive white gaussian noises noise free input arbitrary signal required periodic particular frequency domain maximum likelihood estimator proposed analyzed detail estimators method assumes ratio noise known estimation problem formulated frequency domain shown parameter estimates consistent explicit algorithm computing asymptotic covariance matrix parameter estimates derived possibility effectively use filtered data using part frequency domain discussed analyzed illustrated elsevier ltd rights reserved
paper aim propose parallel multi core hyper heuristic based greedy randomized adaptive search procedure grasp permutation flow problem criterion grasp known two phase metaheuristic first construction phase builds complete solution iteratively component component greedy randomized algorithm local search phase improves solution choice component order added solution mostly depend incremental cost thus basic grasp configuration defined cost function probabilistic parameter structure consider five cost functions seven known structures paper cost function based operator integrated grasp first time mechanisms investigate automatically algorithm configurations refer hyper heuristics hyper heuristic investigates grasp configurations reports one produces better results parallel multi core computing used way efficiently implement hyper heuristic benchmark instances used test hyper heuristic permutation flow problem copyright john wiley sons ltd
paper presents method accelerate target recognition processing advanced driver assistance systems histogram oriented gradients effective descriptor object recognition computer vision image processing expected replace conventional descriptors template matching however consider occurrences gradient orientation objects localized portions image region interest roi set precisely size position roi set precisely frame automotive environment target distance changes dynamically use radar determine size position roi propose radar camera sensor fusion algorithm experimental results discussed
drawing basic physics attributed productivity price led decrease rate growth energy consumption mid high post energy use growth rates observed countries fell drastically decreasing productivity growth however since considerable cast view example rate growth energy use manufacturing specifically electricity use fall price electricity either unaffected increased slightly afterwards second fall without usual lag third energy consumption growth rates return pre level real energy prices returned pre levels drawing kinetics paper presents alternative hypothesis namely energy demand related factors notably physical limits energy based speed ups energy supply related factors behind sudden decrease productivity growth hence behind productivity specifically many industries sectors maximum machine speed velocity near reached late early making increases physically impossible economically viable elsevier ltd rights reserved
helpful legal punishment neighbor help preventing parents physical child abuse real life setting uncertain question concern considering prevailing advocacy preventing child abuse community address question study examines preventive effects survey high school students chinese shanghai results reveal significant preventive effects legal punishment neighbor help physical abuse father mother respectively addition legal punishment mother tended reduce fathers physical abuse presence neighbor help results support ecological theory joint contribution complementary resources obtained different sources results imply merit support parents neighbors legal authorities preventing child abuse elsevier ltd rights reserved
simulation based studies become interesting investigation approach software engineering however reports experiments dynamic simulation models found technical literature lack relevant information full understanding procedures results reported apart limitations length journal papers relevant information seems missing due methodological issues considered conducting studies case missing research questions goals lack evidence regarding dynamic simulation model validity poorly designed simulation experiments amongst others based findings previous quasi systematic literature review propose set reporting guidelines dynamic models context aiming providing guidance information report contain furthermore guidelines evolved support planning identifying potential threats simulation study validity making recommendations avoid qualitative analysis external evaluation finally conducted different evaluations regarding reporting planning guidelines apart using support planning regards software evolution set reporting planning guidelines different stages simulation lifecycle focused experimentation dynamic simulation models put together first assessments point comprehensive set guidelines supporting comprehensive preparation review plans reports studies apart planning focused software evolution potentially reducing threats experimentation validity dynamic simulation models guidelines understood separate groups reporting planning overlap many aspects main goal use guidelines support planning simulation based study dynamic models identify potential threats validity produce relevant information complete simulation experiment report advance despite initial contribution increase validity reporting planning simulation based experiments dynamic models still discussed improved therefore additional assessments set guidelines needed strengthen confidence completeness usefulness
concentration eight heavy metals surface groundwater around export processing zone industrial area investigated health risk posed local children adult residents via ingestion dermal contact evaluated using deterministic probabilistic approaches metal concentrations except river water drinking water quality guidelines groundwater less recommended limits concentration metals surface water decreased function distance estimations non carcinogenic health risk surface water revealed mean hazard index values combined pathways ingestion dermal contact age groups estimated risk mainly came ingestion pathway however values examined metals groundwater adult children respectively deterministic probabilistic estimations cancer risk exposure groundwater safety limit overall population exposed river water remained carcinogenic non carcinogenic health threat risk higher adults sensitivity analysis identified exposure duration ingestion rate water relevant variables affecting probabilistic risk estimation model outcome elsevier ltd rights reserved
field data analysis clustering powerful technique groups data different subsets using distance function data belonging subset similar nature offer heterogeneity data reside subsets clustering proved various fields bioinformatics pattern recognition image processing many paper two step artificial colony abc algorithm proposed efficient data clustering two step abc algorithm initial positions food sources identified using means algorithm instead random initialization along discover promising search areas improved solution search equation based social behavior pso applied phase abc algorithm food source location found using based direct search method five benchmark two artificial datasets applied validate proposed modifications abc algorithm results study compared known clustering algorithms experimental statistical analyses show improvements abc algorithm advantage conventional abc algorithm solving clustering problems
men often affected cognitive distortions related gender roles violence valid way solve conflicts objectives research analyze psychometric properties inventory distorted thoughts women use violence revised non updated items compare predictive ability revised version measures network sample consisted men men men normative population mean age years results showed acceptable fit indices structure new version items alpha higher original version items score showed statistically significant correlations self reports measure social ambivalent analyzing cutoff points differentiate men normative group higher discriminative ability compared hostile dimensions conclude instrument adequate psychometric properties detect cognitive biases violent men partner presented instrument useful clinical purposes
purpose objective study determine incidence injuries playing hours severity days absence cause match injuries womens methods performed prospective epidemiological study injury elite national female players elite teams elite applying methodology injury definitions compliant international consensus statement research injuries occurred usa series usa local area union national star series usa results one hundred twenty time loss injuries encountered elite injury rate injuries injury rates national level elite candidates mean days missed found elite level players per injury whereas acute injuries significant resulting immediate removal pitch main mechanism injury occurred tackling players common type injury seen ligament sprains involving lower extremity common body parts injured knee head face conclusions time loss injuries occurred frequency womens overall injury rates women lower international elite men womens head neck area female players injured greater rates international male injury prevention womens focus injuries knee head neck understanding risk factors allow safe return play decisions formulate injury prevention protocols
quality life often relatively lowered families children additional needs particularly case additional needs accompanied autism spectrum disorder asd explore effects diagnostic status specifically comparing families children asd diagnosis others additional needs signs asd additional needs signs asd diagnosis mothers children additional needs completed standardised questionnaires quality life stress service provision child behaviour presence severity asd traits addition group mothers typically developing young people completed standardised questionnaires individual family quality life behaviour son mothers typically developing young people significantly higher individual family quality life scores three groups increased severity asd associated increased maternal stress turn associated decreased family maternal quality life group reporting lowest quality life highest stress mothers individuals signs asd diagnosis pattern seem explained lack access services rates intellectual disability challenging behaviour sub group finding poor quality life high stress apparent sub group mothers children signs asd diagnosis asd suggests interesting topic investigation whether receipt diagnosis positively influence quality life levels maternal stress
voltage regulation fluctuations power distribution systems represents important matter electricity customers utilities distributed energy resources proven provide solutions satisfying demand also providing voltage control support electrical network reinforced coordination control actions distributed generation long designed optimal way order improve network voltage performance distributed control strategy based state based potential games proposed work control strategy applied test system illustrating benefits viability proposed approach
micrornas mirna small noncoding rnas affect broad range biological processes including tumorigenesis targeting gene products directly regulate cell growth human old type ifn inducible specific mrnas small noncoding rnas present study examined effect enzyme mirna expression human melanoma cells mirna microarray analysis human melanoma cells infected empty expressing old identified mirnas differentially specifically regulated old one mir regulator cyclin dependent kinase inhibitor displayed robust regulation regulation expression old also occurred multiple human melanoma cells upon ifn beta treatment using vivo immunoprecipitation followed northern blotting rna degradation assays confirm mature mir target old inhibition old stable overexpression mir protected melanoma cells ifn beta mediated growth inhibition importance old induction mir regulation mediating ifn beta action moreover now uncover mechanism mirna regulation involving selective enzymatic degradation targeted overexpression old provide effective therapeutic strategy mir overexpressing ifn resistant tumors melanoma
introduction prostate cancer pca common disease male patients androgen dependent aim current study provide overview interest testosterone dosage management pca regardless stage disease patients methods systematic review literature done pubmed database searching following key words alone combination prostate cancer testosterone risk aggressiveness active surveillance prognosis androgen cardiovascular risk biochemical recurrence results level testosterone depends moment day peak end night morning test either whole testosterone level free testosterone level testosterone testosterone representative presence androgen tissues specialized laboratory mandatory testosterone rate potentially useful several steps pca management localized prostate cancer cases men low testosterone levels likely aggressive disease therefore good candidates active surveillance extensive radical considered case young men since patients likely subsequently advanced prostate cancer cases testosterone level less equal guarantee appropriate patient undergoing androgen deprivation treatment dissociation trend psa testosterone levels starting point resistant period disease conclusion testosterone level bring useful information regarding profile pca ability evolve whole natural history disease elsevier masson sas rights reserved
interpolation valuable tool program analysis verification modern solvers implement interpolation procedures theories commonly used applications however many application specific theories remain limits class problems interpolation based techniques apply paper present generic framework build new interpolation procedures via reduction existing interpolation procedures consider case application specific theory extension base theory additional symbols technique uses finite extension reduce interpolation problem theory extension one base theory identify model theoretic criterion allows detect cases technique complete discuss specific theories relevant program verification satisfy criterion particular obtain complete interpolation procedures theories arrays linked lists latter first complete interpolation procedure theory supports reasoning complex shape properties allocated data structures
paper presents results liquid water injection cylinder compression expansion internal combustion engine ice aim achieving optimal cylinder pressure improving power output using cfd simulation employing compression stroke degrees angle top dead centre resulted reduction compression work due reduction peak compression pressure margin decreased peak compression pressure also yielded benefit decrease nox emission margin prevention using expansion stroke top dead centre revealed two stages cylinder pressure first stage involved decrease pressure heat absorption second stage involved increase pressure result increase steam volume via expansion case water addition water temperature degrees percentage decrease cylinder pressure first stage pressure increase second stage water injection helped reducing energy losses resulting transfer heat walls exhaust gases degrees exhaust gas temperature decreased respectively increasing temperature degrees resulted decrease cylinder pressure first stage increase approximately second stage use compression expansion resulted maximum increase cylinder pressure demonstrating potential higher power output
purpose symptoms urinary irritation urgency frequency obstruction known lower urinary tract symptoms common practice however little known etiology pathogenesis lower urinary tract symptoms especially relative contributions genetic environmental factors development symptoms used classic twin study design examine relative contributions genetic environmental factors occurrence lower urinary tract symptoms middle aged men materials methods twins members era twin registry used survey collect data lower urinary tract symptoms using pss international prostate symptom score instrument twin correlations biometric modeling used determine relative genetic environmental contributions variance pss total score individual items results participants middle aged male twin pairs mean age years nearly sample pss greater indicating least moderate lower urinary tract symptoms heritability total pss heritability estimates ranged nocturia moderate heritability urinary frequency urgency conclusions genetic factors provide moderate contribution lower urinary tract symptoms middle aged men suggesting environmental factors also contribute substantially lower urinary tract symptoms future research needed define specific genetic environmental mechanisms underlie development symptoms conditions associated lower urinary tract symptoms
despite benefits smoke free legislation adult health little known impact childrens health examined effects tobacco control policies rate emergency department visits childhood asthma ear infections respiratory infections using outpatient visit data new used negative binomial regression models analyze effect state local smoke free legislation visits health condition controlling cigarette health care reform legislation found changes overall rate visits asthma ear infections upper respiratory infections implementation state local smoke free legislation cigarette increases however interaction childrens age revealed among year olds state smoke free legislation associated reduction visits asthma adjusted incidence rate ratios reduction ear infections reduction upper respiratory infections found overall reduction visits lower respiratory infections implementation state smoke free legislation implementation health care reform also associated reduction childrens visits ear upper respiratory infections results suggest state smoke free legislation health care reform effective interventions improve childrens health reducing visits asthma ear infections respiratory infections elsevier inc rights reserved
one important methods treated wastewater soil aquifer treatment simulation three columns diameter height filled sandy soil used assess removal chemical biochemical oxygen demands cod nitrogen phosphate total dissolved solid total fecal treated wastewater soil surfaces columns covered different materials one geotextile another coarse structural debris third one remained bare columns saturated treated wastewater treatment plant experiments conducted permanent saturated soil condition removal percentages geotextile soil column cod fecal phosphate respectively low efficiency nitrate removal columns also observed time leads decrease pollutant removal using geotextile structural debris soil surface covers lead reduction pollutants transfer help stabilizing soil system filter
background fractional exhaled nitric oxide safe convenient test assessing airway inflammation potentially useful management patients chronic cough objective summarize current evidence diagnostic usefulness predicting inhaled corticosteroid ics responsiveness patients chronic cough methods systematic literature review conducted identify articles published peer reviewed journals february without language restriction included studies reported usefulness index test predicting ics responsiveness reference standard patients chronic cough target condition data extracted construct accuracy table study quality assessed quality assessment diagnostic accuracy studies results identified original studies prospective retrospective studies identified considerable study design outcome definitions thus unable perform meta analysis proportion ics responders ranged sensitivity specificity ranged respectively reported area curve ranged however studies prospective design lower prevalence asthma lower area curve values none measured placebo effects objective cough frequency conclusions find strong evidence support use tests predicting ics responsiveness chronic cough studies need randomized placebo controlled design use validated measurement tools cough standardization facilitate development clinical evidence published elsevier inc behalf american academy allergy asthma immunology
youth leadership programming become increasingly common context foster basic psychological needs promote youth development purpose qualitative study explore strategies involved fostering youth needs support within six leadership programs two leaders youth participated semi structured interviews better understand strategies used foster needs support findings revealed leaders able foster sense relatedness among youth building adult youth relationships inclusive environment maximizing choice youth voice helped foster youths autonomy finally creating task oriented climate providing intentional opportunities skill building helped foster youths competence findings suggest training leaders critical understanding strategies employed help foster youth needs support leadership programming limitations future directions outlined elsevier ltd rights reserved
paper study new stabilized method based local pressure projection solve semi linear elliptic equation proposed scheme combines finite element pairs triangle element two level method number attractive computational properties parameter free avoiding higher order derivatives edge based data structures favorable stability less support sets stability analysis error estimates done finally numerical experiments check estimates presented
studies attribute markets seasonality assume seasonal affective disorder sad creates seasonal fluctuations risk turn affects prices employing variance risk directly test seasonality risk find significant seasonality explained exogenous events market realized variance returns major variables use number people actively suffer sad show consistent sad hypothesis sad significantly positively correlated international comparison reveals significant positive association magnitude prevalence sad
background objective assess impact obstetric mode delivery particular birth section school performance adolescents using large population based cohort methods extracted data swedish medical birth register national school register included live births sweden school grades reported scale scores less pass considered poor school performance mode delivery vaginal delivery assisted elective emergency measured association mode delivery poor school performance using logistic regression used regression assess association mode delivery school performance across distribution scores adjusted maternal age parity small large gestational age gestational age maternal country birth maternal depression non affective disorder bipolar disorder parental income time birth parental social welfare time birth also conducted sensitivity analyses investigate association results logistic regression analysis adjusted odds ratio aor assisted poor school performance compared elective emergency regression assisted showed little difference scores compared point across distribution elective associated point decrease scores emergency associated point decrease scores conclusion slight association found birth school performance however effect quite small given complex nature relationship interpreted caution
study examined prosocial compensating behavior towards socially excluded ingroup outgroup members using prosocial game year old dutch adolescents results showed adolescents compensated social exclusion unknown peer virtual ball game ball often player compensation conditions compared fair play condition proportion towards excluded player significantly differ function group status player although compensating behavior towards ingroup versus outgroup members differ underlying motivation behavior vary empathic concern associated prosocial towards ingroup member self reported bullying behavior associated less compensating behavior outgroup condition findings practical implications programs change behavior bullying situations foundation professionals services adolescents published elsevier ltd rights reserved
recently rainwater harvesting systems received increased attention due capability adapting water scarcity climate change however key obstacle implementation rainwater harvesting systems often feasible given difficulty determining optimal system size key premise previous studies rainwater harvesting systems constructed single construction event even though possible construct system multiple stages assumption limits managerial flexibility construction rainwater harvesting systems particularly valuable scenarios difficult forecast future rainfall patterns therefore propose multi stage system expansion strategy implementation rainwater harvesting systems using septic tanks scenarios uncertainty rainfall real option perspective means improve financial feasibility implementing rainwater harvesting systems tested strategy evaluating proposed rainwater harvesting system complex south korea multi stage expansion strategy generated option value study help improve financial feasibility rainwater harvesting systems adding value managerial flexibility sequential expansion rwh systems new information becomes available
objectivesto evaluate efficacy safety compared treatment female patients overactive bladder randomized receive twice daily daily weeks primary efficacy end point change total overactive bladder symptom score secondary efficacy end points included change overactive bladder symptom score day diary international prostate symptom score overactive bladder questionnaire safety assessments included adverse events vital signs post void residual volume patient reported incidence severity distinctive symptoms related adverse events resultsthe group showed significantly reduced mean total overactive bladder symptom score baseline significant differences noted change total overactive bladder symptom score compared group significant improvements secondary efficacy end points observed regarding mean number mean number urgency episodes mean number incontinence episodes mean volume total international prostate symptom score quality life groups significant differences groups overall incidence adverse events incidence dry mouth significantly higher group group patient reported incidence severity dry mouth significantly exacerbated group daily effectively overactive bladder symptoms women fewer adverse events treatment
paper presents step step heuristic algorithm reconfiguration radial electrical distribution systems aiming power loss minimization proposed methodology based dynamic switches set approach updated due topological changes electrical network avoid premature convergence algorithm suboptimal solutions moreover proposed algorithm considers demand variation system load curves determines sequence switching operations reconfiguration process obtain feasible operation points intermediate stages process network state reconfiguration stage analyzed using conventional power flow algorithm proposed methodology applied systems literature evaluate effectiveness elsevier ltd rights reserved
tunneling method machine launched received ground surface level developed tunneling areas paper reports monitoring results full scale test conducted first tunneling project china investigation special attention paid tunneling phases machine buried super partially ground surface paper focuses tunneling induced soil movements process measurement results indicated surface represented commonly used gaussian function regardless cover depth load factor approach provides fair prediction volume loss transverse soil displacement field identified pattern although expanding displacement field observed several locations pressure measurements used identify time dependent response process
image enhancements lead improved performance increased accuracy feature extraction recognition identification classification hence change detection increases utility remote sensing suit environmental applications aid disaster monitoring involving large areas main aim study compare effect image enhancement applied synthetic aperture radar sar data landsat imagery identification mapping methodology involved pre processing landsat imagery image registration sar data landsat imagery enhanced principal independent component analysis pca spectral index involving bands using false colour composite components bearing information sar data processed using edge filters computation sar enhanced spatial edge information sar data incorporated spectral information landsat imagery knowledge based classification methodology tested central kenya characterized terrain frequent rainfall induced results showed sar data complemented landsat data enriched spectral information afforded enhanced information sar classification depicted along important information lacking landsat image classification success identification classification attributed enhanced features spectral roughness properties elsevier rights reserved
background clinically genetically heterogeneous despite first line testing tool heterogeneous inherited disorders whole exome sequencing yet evaluated diagnostics set pilot study address yield whole exome sequencing early onset generalized disease subtype enriched methods clinical whole exome sequencing coupled bioinformatics analysis detailed mutation carriers performed consecutive cases genetically undefined early onset generalized candidate pathogenic variants validated tested whole exome approach complemented analyzing mutated yet causative genes another cases results whole exome sequencing detected clinically relevant mutations known related genes generalized cases among novel variants reflecting locus heterogeneity identified unique variants distributed genes mutated three genes associated isolated generalized whereas gave rise combined phenotypes follow screening revealed set distinct variants interest pathogenicity supported bioinformatics testing work conclusions study identified whole exome sequencing effective strategy molecular diagnosis early onset generalized offers insights heterogeneous genetic architecture condition furthermore provides confirmatory evidence relevant role likely associate broader spectrum expressions previously thought international parkinson movement disorder society
objectives adults irritable bowel syndrome ibs bacterial gas production colonic fermentation related symptom generation intestinal transit whether gas production affects symptom generation psychosocial distress intestinal transit childhood ibs unknown methods children ages years pediatric rome iii ibs completed validated psychosocial questionnaires week daily diary capturing pain characteristics stool form determined ibs subtype subjects completed hour breath test measurement total breath hydrogen methane production red used determine whole intestinal transit time results total children mean age standard deviation years enrolled girls children produced hydrogen produced methane hydrogen methane production correlate either abdominal pain frequency severity psychosocial distress hydrogen methane production differ significantly ibs subtype methane production correlated positively whole intestinal transit time inversely bowel movement frequency methane production threshold ppm marker identifying ibs sensitivity specificity conclusions breath test total methane production serve biomarker whole intestinal transit time bowel movement frequency children ibs children ibs breath test hydrogen methane production however correlate abdominal pain ibs subtype psychosocial distress
mechanics blood flow epigenetic influence exerts heart function subjects intense research fetal flows especially useful gaining insights development congenital heart diseases received due attention thus far likely technical difficulties collecting sufficient flow data safe manner circumvent obstacles employing ultrasound scans quantify fetal heart motion three normal week fetuses subsequently performing computational fluid dynamics simulations left based patient specific heart movements analysis simulation results shows significant differences fetal adult ventricular blood flows arise heart morphology ratio diastolic systolic duration ratio heart rate ventricular vortex rings observed wave flow simulations sufficient momentum last end responsible generating significant wall shear stresses myocardial endothelium systolic outflow based findings previous studies hypothesized vortex induced flow properties play important role sustaining efficiency diastolic filling systolic pumping cardiovascular flow normal fetal
article examines positions group black women journal dedicated women color century analysis positions racial gender claim raised authors open debate interacts gender racial brought structure addressing turning points discourse also form part discussion attachment traditional gender roles interpretations legacy developed contemporary academy
capability approach developed approach simultaneously framed alignment dominant social structure individual agency within frame social power structures examining agency empowerment gained mobile phone usage foreign singapore use perspective gender studies find facing multiple grounds discrimination dominant group women constantly negotiate gender ethnicity social class leading two active strategies positive empowerment gender aspiration mobile phone found active agent facilitating aspiration individual changes autonomy powerful decision making roles domestic social domains variety communicative practices developed capabilities hand also mediated practices foreign essential beliefs traditional gender roles contrast dominant development discourse womens empowerment socio cultural contexts influencing processes technological discussed perspective development particularly framing western notions gender equality within framework
paper proposes novel rotation invariant feature object recognition firstly local fourier transform features pixels described region encoded fisher vectors encoded vectors aggregated final representation ordinal described region sub regions based orders pixels rotation since encoded fisher vectors ordinal strategy rotation invariant extracted feature rotation invariant nature two kinds rotation investigated framework one radial gradient orientation radial gradient angle experiments digit recognition car detection aerial images demonstrate effectiveness proposed method outperforms state art elsevier rights reserved
article aims investigating filtering abilities periodic structures nonlinear interconnected synchronized switch damping inductor electrical networks periodic structures without electrical networks naturally function filtering since structure response breaks pass bands stop bands structure excited external force multiple varying frequencies introduction linear electrical networks periodic structure makes stop bands structure wider structure without electrical networks however nonlinear piezoelectric electrical networks better effect mechanical wave attenuation linear piezoelectric electrical networks terms frequency band therefore article proposes piezoelectric periodic structure nonlinear interconnected synchronized switch damping short circuit synchronized switch damping inductor electrical network transfer matrix formulation including interconnected electrical network also proposed deriving characteristics elastic wave propagation results show proposed technique permits enhancing damping abilities particular frequency bands compared electrically independent periodic cells combined structural tailoring allow achieving high damping performance
people criminal behavior greater detail description crime written using aspect experiment initiative reproduce findings conducted yielded lack replication suggested original effect likely driven type error produced methodological aspects experiment including low sample size recent conceptual effect however imply effect contingent sample characteristics
paper presents design modeling control novel wave energy converter using dielectric electro active polymer application attracted lot works due development renewable energy increasing human energy demand however various challenges using overcome going realistic application firstly ratio significant influence energy conversion efficiency exceed limitation value due mechanical electrical breakdown whereas small ratio reduces energy conversion efficiency significant secondly controlled maximize absorbed energy therefore study employs innovative device adjust inertia floating variable inertia hydraulic attached main thrust shaft control ratio based change hydrodynamic behavior system proportional integral derivative pid controller designed optimize ratio different regular waves consequently overall energy conversion efficiency proposed reach
objective high resolution peripheral quantitative computed tomography novel imaging modality capable visualizing bone vivo human peripheral sites distal radius distal tibia research extended technology provide non invasive assessment bone human knee establishing new hardware imaging protocols data analysis design custom leg developed stabilize human knee centrally within second generation field view five participants anterior cruciate ligament reconstructions knee joint continuous scan nominal voxel size bone mineral density assessed within weight bearing regions medial lateral compartments knee three depths weight bearing articular bone surface including cortical trabecular bone regions results scan duration approximately min per knee produced projection data reconstructed image data image matrix slices motion scan minimized leg similar magnitude scan distal tibia bone mineral density parameters assessed volumes interest joint conclusions new non invasive vivo assessment tool bone human knee provides opportunity gain insight normal injured surgically reconstructed human knee bone architecture cross sectional longitudinal studies crown copyright published elsevier inc rights reserved
argument based machine learning knowledge refinement loop offers powerful knowledge tool suitable obtaining expert knowledge difficult domains paper first use difficult even defined concept distinguishing basic advanced programming style python programming language teach concept interactive learning session student computer demonstrate automatically selecting relevant examples counter examples explained student knowledge refinement loop provides valuable interactive teaching tool
formation damage due formation injected low salinity water decreases relative oil increases residual oil saturation decreases oil recovery presence swelling shock effect sudden water injection results increase formation damage clay minerals cause formation damage due swelling migration production oil gas therefore good understanding damage mechanisms helps prevent remedy possible damage reservoirs work effect clay swelling behavior oil recovery factor pore scale using glass studied clay coated sodium swelling clay prepared using image processing technique ultimate oil recovery factors flooding low salinity water high salinity water estimated effect clay swelling phenomena oil recovery factor studied final residual oil saturation higher used injection fluid compared used fact said clay swelling inhibits film flow injection fluid causes oil elsevier rights reserved
recent years deep learning attracted increasing amount attention machine learning artificial intelligence areas currently many deep learning network related architectures deep neural networks convolutional neural network cnn wavelet scattering network principal component analysis network proposed effective network achieved promising performance image classification face object digit recognition handle data represented single view features paper present canonical correlation analysis network address image classification images represented two view features two view multistage filter banks canonical correlation analysis method constructs cascaded convolutional deep network incorporate filters block wise histogram processes form final depth structure addition introduce variation filter banks randomly generated extensive experiments conducted using databases object classification face classification classification respectively experimental results demonstrate algorithm effective elsevier inc rights reserved
goal article present role technology transit different stages mathematical modeling cycle since began development course involves mathematical modeling perspective principal mean learning differential equations presented design specific situation related circuits electric context activities based use diverse technology based study describes types tasks related mathematical modeling cycle technology applied also former ones propose better transit diverse domains modeling cycle conclude future lines research
many women shorter distances less time men research effects racial ethnic segregation access transportation minority womens since growing income inequality bifurcation employment paid secure jobs growing number insecure poorly paid jobs accompanied concentration jobs central locations transformation womens roles labor market investigate geographical implications trends analyzing new york metropolitan region gender race differences varied across metropolitan area regression analysis demonstrates impacts household composition differ highly valued center benefited private public investment traditional gender roles persist inner ring minority women still long times slow public transit findings highlight racial gender disparities geographical access employment within metropolitan region
paper proposes energy efficient light emitting diode led driver applications interior lighting high efficiency achieved adaptive voltage regulation minimizes power losses linear current regulator digital control mechanism employing resistive digital analog converter feeding analog feedback input converter introduced shown digital control methodology gives maximum design flexibility enhances control regulation speed stability experimental setup proposed concept verified evaluated operating input voltage led driver provides relatively wide output voltage range output current regulated steady state precision whereas modulation frequency khz shortest time employed peak efficiency complete system achieved
improving energy efficiency buildings windows play significant role largely influence energy load although many studies energy efficient window design rigorous study missing analyzes mutual impact windows size position orientation energy load study aims address gap case study single family house aim different design scenarios created vary window size position orientation building information models created scenario via used calculation total energy load conducted green building first analysis stage window wall ratio windows position studied assess effect energy load preliminary results stage indicate total energy load increases grows windows position biggest impact load using results next stage position windows different orientation studied assess energy load changes windows position orientation results show building requires lowest load windows located middle height orientations east windows positioning affects total energy load
order study evolution mechanism forecast development direction green building market paper establishes model asymmetric evolutionary game green building market using idea evolutionary game firstly dynamic equations two strategies set using idea dynamics evolution game lastly evolutionary game equilibrium model established analysis results show build green green build non green non green two evolutionary stable situations empirical analysis development green building country divided three development stages analyzing evolution characteristics stage evolution mechanism development trend green building country obtained
present research examined effects pre encoding pre recall induced mood episodic memory hypothesized happy angry mood prior encoding increasing left hemisphere activity tandem mood prior recall increasing right hemisphere activity associated superior episodic memory also hypothesized membrane measures indicative activity change function induced mood although experienced mood induction successful pre encoding pre recall mood alter memory altered pre encoding fear pre recall angry mood induction conditions interestingly baseline absolute difference left right measure differential activity regardless direction activity significantly positively related number total words written number correctly recalled words corrected recall score measure pre encoding regardless specific mood significantly negatively related false recall results discussed terms model episodic memory nature interaction involved episodic recall elsevier inc rights reserved
hepatocellular carcinoma hcc also called malignant one cancers due complexities surgical resection metastasis heterogeneity incidence mortality hcc increasing western countries expected rise consequence obesity epidemic multiple factors trigger initiation progression hcc including chronic alcohol consumption viral hepatitis infection metabolic disorders age although fda approved drug treatment hcc numerous treatment modalities arterial radiotherapy therapy chemotherapy tested clinics polymeric nanoparticles carrying small molecules proteins peptides nucleic acids attracted great attention treatment various cancers including hcc herein discuss pathogenesis hcc relation various recent treatment methodologies using monoclonal antibodies small molecules mirnas peptides recent clinical trials peptide drugs presented broad overview pathogenesis disease treatment efficacy elsevier inc rights reserved
collection storage management anticipation contextual information user support decision making constitute key operations ambient intelligent ami systems computer based class often difficult confirm students working proposed activities order mitigate problems occur environment learning technologies suggest ami system aimed capturing measuring students level real scenarios dynamically provide recommendations system possible assess individual group attention real time providing measure level engagement student proposed activities allowing better teaching methodologies
applied computer laboratory lessons many students correcting students one one time especially caused complex integrated development environments study develop client server application computer laboratories developed application able programming language source code remotely thus students need make something writing source code furthermore instructors need install computer laboratory start enough server just configured authors published elsevier ltd
space filling visualization model first maximizing utilization display space relational data graph visualization especially tree visualization uses concept edges graphic representation frequently used traditional node link based graph visualizations therefore major issue graph visualization edge crossing naturally solved adoption space filling approach however past space filling concept attracted much attention researchers field multidimensional visualization although problem edge crossing also occurred among used basic visual elements parallel coordinates visualization problematic edge among distributed display plate visual occur problem significantly reduce human terms reviewing particular region visualization study propose new space filling multidimensional data visualization first time introduces space filling approach multidimensional data visualization main contributions achieving maximization space utilization multidimensional visualization display area fully used eliminating visual use non classic geometric primitive improving quality visualization visual perception linear correlations among different variables recognizing data patterns evaluate quality conducted usability study measure performance comparison parallel coordinates matrix finding linear correlations data patterns evaluation results suggested accuracy better terms perceiving linear correlations also efficient less time required recognizing data patterns elsevier inc rights reserved
objective needle free injection device performed pharmacokinetic study investigate methotrexate administered subcutaneously using either needle free injection device conventional needle research design methods single dose open label laboratory blind randomized crossover study performed adult healthy volunteers participant received two methotrexate injections one via needle free injection device one via conventional injection interval dosing participant administration site injections either abdomen main outcome measures primary pharmacokinetic outcome parameters auc max assessed standard criteria whether confidence intervals geometric mean ratios two administration methods within results fifty two individuals completed study criteria met auc overall analysis injection sites confidence interval injection site separately similarly demonstrated auc criteria max fulfilled abdominal administration overall analysis injection via needle free injection device limitations include conducting study healthy volunteers relatively small subject number albeit satisfactory conclusions study shows methotrexate injection via needle free injection device conventional needle relation auc auc studies needle free injection device use patients requiring methotrexate therapy planned
common engineering problem manufacturing identifying many possible factors influences response interest words causing performance reliability quality cost issue evolutionary operations commonly called muscle manufacturing operations generate large data sets minimal disruption factory capture natural variance materials processes materials used manufacture product experiments methods guide experimental plans supports statistical analysis data upon sound conclusions interpretations drawn paper presents methods applied together problem screening many factors find influence particular response interest case study virtual cell factory presented
investigation paper fourth order variable coefficient nonlinear schrodinger equation describe inhomogeneous one dimensional anisotropic ferromagnetic spin chain alpha helical protein aid hirota method symbolic computation bilinear forms dark one two soliton solutions obtained influences variable coefficients dark one two solitons graphically shown discussed amplitude shape dark one soliton keep invariant propagation variable coefficients chosen constants variable coefficients functions amplitude dark soliton keeps unchanged propagation direction soliton curves head collisions dark two solitons displayed variable coefficients chosen constants shown shapes two solitons change collision choose variable coefficients functions directions two solitons change elastic collisions occur two solitons
non uniform flow patterns result significant losses separation efficiency compared conditions straight flow paths improve flow pattern via design accurate prediction achievable separation efficiency better understanding flow formation required however straight forward since evolving patterns depend column design operating conditions cover configurations continuous liquid rising bubble regime continuous gas phase carrying liquid droplets spray regime study wire mesh sensor technique used visualize flow patterns larger technique tracks conductivity tracer pulses passage across proper calibration routine developed methodology proposed determine point liquid residence time distributions liquid velocities experiments carried column diameter feasibility study included experiments different liquid capacities various outlet benchmark data high spatio temporal resolution obtained suitable validation cfd models flow simulation industrial scale institution chemical engineers published elsevier rights reserved
paper switching flow graph models developed study nonlinear behavior switching converters based concept virtual switches virtual switching functions switching flow graph sfg model created easily without complex mathematics sfg modeling technique helpful undergraduate students understand switching converters operate different switching states students also learn develop model observe cause effect relationship converters variables research basic converter used example reveal dynamic behavior switching converters operated students enhance concept circuit design developing sfg model software simulate various conditions
studies identified prenatal exposure determinant taste preferences infants however studies focused relatively small samples limited many parents struggle getting children accept variety foods study factors influencing food acceptance warranted objective study determine whether exposure wider variety fruit vegetables overall higher diet quality utero results acceptance greater variety foods better diet quality offspring childhood study secondary data analysis pregnant women resulting offspring recruited women childrens health study australia dietary intake mothers children measured using food frequency questionnaires diet quality vegetable fruit variety calculated using australian recommended food score australian child adolescent recommended food score associations maternal child diet quality variety assessed using pearsons correlations total effect utero maternal pregnancy diet childhood diet decomposed direct indirect effect using mediation analysis maternal pregnancy post diet correlated child diet overall diet quality fruit vegetable variety mediation analyses showed indirect effect maternal pregnancy diet child diet mediated maternal post diet particularly fruit vegetables nutrition intervention therefore aimed improving diet quality variety mothers young children order subsequently improve eating habits offspring
similar renewable energy sources wind energy characterized low power density hence wind energy make considerable contributions worlds overall energy supply large wind farms offshore consisting arrays ever larger wind turbines built fluid mechanics perspective wind farms encompass turbulent flow phenomena occurring many spatial temporal scales particular interest understanding mean power extraction fluctuations wind farms scales ranging comprise behind individual wind turbines motions reaching scale inherently associated atmospheric boundary layer review summarize current understanding flow phenomena particularly mean second order statistics field studies wind tunnel experiments large eddy simulations analytical modeling emphasizing relevant features wind farm design operation
better understand interactions pathways activation detoxification metabolism putative administered dose scheduled colon surgery blood urine collected next evaluated linear accelerator mass spectroscopy counting identify specific metabolites phenol phenotype correlated levels urine activity negative correlation serum levels positive correlation urine levels low level method determining influence phenotype metabolism significantly improve understanding pathways provide critical foundation development individual risk assessment elsevier science ireland ltd rights reserved
despite enormous empirical success formalism quantum theory still raises fundamental questions nature described terms complex hilbert spaces modifications reasonably expect find regimes physics address questions studying compatibility thermodynamics structure quantum theory employ two probabilistic theory reasonable thermodynamic behaviour arguably satisfy framework generalised probabilistic theories show already imply important aspects quantum theory like self analogues measurements eigenvalues however still class theories beyond quantum mechanics using thought experiment von show theories consistent thermodynamic notion entropy prove second law holds measurements mixing procedures furthermore study additional entropy like quantities based measurement probabilities convex decomposition probabilities uncover relation one quantities notion higher order interference
pre mrna fragile mental retardation gene subject exon alternative splice site selection generate isoforms expression function variants vivo yet fully explored present study investigated distribution exon exon isoforms exon encodes extension domain one rna binding domains gene product show exon variant proteins differentially interact complex rna alternative splicing exon produces differing rna binding ability distinguished unique post translational modifications using pcr northern blotting found particular exon exon isoforms change neuronal differentiation interestingly exon variants display tissue specific developmental differences exon containing transcripts vary less altogether spatio temporal plasticity mrna consistent complex rna processing mis regulated fragile syndrome elsevier inc rights reserved
ubiquitous computing term used human interaction computers virtually almost embedding computers daily lives create active intelligent environment future phase computers beyond desktop environment currently progressively deeper inside new phase ubiquitous computing mainly focus computer integral part human unaware presence computer scientists focusing hard ways interaction human computer simplified think era hundreds computers unique task irrespective location time keeping human unaware article explore evolution ubiquitous computing origin history architecture role privacy integration privacy system design features technical challenges ubiquitous computing third wave computing begun just now field require considerable efforts match current technological developments according view computer scientists engineers future technological advancement field world
purpose nocturia sleep problems common older adults developed tested novel intervention behavioral treatment exercise therapy bet reduce nocturia improve sleep men compared reductions nocturia improvement sleep men bet versus active drug comparator alpha blocker used alone combination bet alpha blocker methods randomized controlled trial conducted ambulatory setting department veterans medical centers men least years age nocturia defined episodes participants randomized receive either bet including pelvic floor muscle training urge suppression techniques delayed voiding fluid management sleep hygiene peripheral edema management active comparator known efficacy alpha blocker one tablet therapies combined participants received interventions weeks outcomes assessed via voiding diaries wrist actigraphy validated questionnaires primary outcome change diary recorded nocturia assessed using group changes paired tests within group changes findings total men mean age years participated weeks mean diary recorded nocturia changed bet episodes night alpha blocker therapy episodes night combination therapy episodes night reductions statistically different across treatment groups bet also showed statistically significant improvements sleep quality nocturia nocturia specific quality life treatment groups indicated global satisfaction treatment implications behavioral therapy men alone combined blocker therapy consistently showed large statistically significant nocturia reductions favorable effects sleep quality life based findings behavioral therapy statistically superior alpha blocker therapy provide meaningful treatment option men nocturia future research include development behavioral treatment exercise therapy interventions easily deployed published elsevier journals inc
verifying complex systems power plants satisfy requirements ensure proper operation particular respect safety environmental regulations difficult due large number potential situations explored terms initiating events chain consequences behavior system paper presents new framework supporting methodology aims innovation ability modify system safety ability comply regulatory requirements general principle produce independently formal models requirements possible variants design dynamic behavior system possible designs assemble together simulate full systems behavior automatically detect possible violations requirements
facile gel method suggested prepare zno photocatalysts nanocomposites zno prepared different amounts zinc oxide precursors prepared products characterised xrd raman vis tem bet eis techniques photocatalytic response zno nanocomposites analysed degradation organic dyes green methylene blue solar light irradiation outcome increased surface area rod like morphology low charge transfer resistance reduced band gap composite zno optimum level zinc contents showed enhanced photocatalytic activity degrading dyes
small noncoding rnas play important roles rna interference rnai addition microrna mirna interacting rna one key member group endogenous small interfering rna sirna studies show role ago mutants however biological functions specific remains mostly unanswered study performed comparative analysis present porcine identified deep sequencing bioinformatics analysis observe large amount specific binding utr porcine generated formed transcript newly identified antisense noncoding rna characterized show regulate early embryonic development inhibiting activity work contribute understanding functional role abundant embryonic development
context around antiretroviral therapy art prevention hiv aids addressing barriers long term art adherence critical particularly important given tendency use discourse exploring hiv infected patients fail adequately adhere art sufficiently exploring contextual reasons poor adherence require varying solutions study took place three clinics one hospital south africa document contextual factors challenged art adherence community interviews conducted hiv infected patients art subsequently admitted hospital clinical complications art service providers including doctors nurses hiv interviews assessed reasons patients art explored ways prevented data groups analysed collectively using thematic analysis interviews revealed landscape environmental risks threatening adherence art patients managed overcome identified barriers point treatment phase indicating patients needs decision making patients reported relationships service providers inhibit understanding art follow clinics patients described rationale agency underlying non adherence testing bodies physical limits without art medication study need contextual social structural barriers related art adherence differently specific sub groups support appropriate response imperative solely loss follow also assess patients subjective trajectory art decision making agency art relations healthcare workers dynamics broader constraints health systems
global increase cultural religious diversity led calls group differences achieve intergroup although much social psychological research examined nature prejudice discrimination impact targets biases little research examined nature impact intergroup relations require people give group norms practices rather mutual integrating research various social sciences explore nature intergroup tolerance including three components acceptance rejection drawing implications future social psychological research explore psychological consequences social groups object consider complex ways intergroup tolerance impacts majority minority groups dynamic interplay societies
forensic sciences verification digital media recordings important aspect electrical network frequency criterion promising technique media recording authentication reference database recorded single point power grid based fact variation across points grid fact valid case system disturbances whereas reference database varies time space post disturbance recorded single point extracted media recorded point grid lead errors forensic examination recordings new method establishing robust reference database using geographical information system gis wide area frequency measurements proposed method based building reference database number frequency sensors deployed grid rather single point minimum number sensors required determined according frequency sensitivity extraction algorithm estimation accuracy frequency sensor sensors locations decided based partitioning power grid set geographical frequency coherent areas novel search algorithm using gis data wide area frequency measurements proposed identify geographical frequency coherent areas different disturbance scenarios results showed proposed method used enhance accuracy database matching process
background prevalence oral mucosal fungal infections increases frequent administration antibiotics corticosteroids immunosuppressive drugs therapeutically used usually associated variety drug interactions furthermore noticeable increase microorganisms resistant preparations films represent modern therapeutic system treatment oral mucosal fungal infection paired high degree patient compliance applied directly onto oral mucosa offers attractive alternative treatment systemic thanks low incidence resistance side effects objective aim work evaluate pharmacokinetic parameters application film prepared solvent casting method method chromatographic method using internal standard developed validated evaluation plasma concentrations method accuracy assays respectively results pharmacokinetic properties studied new zealand white rabbits films containing total dose applied rabbits plasma concentrations determined following application time taken reach maximum plasma concentration drug administration overall elimination half life conclusion experiment suggests oral film valuable alternative administration
computer programming courses aim develop students skills problem solving abilities easily achieved traditional teaching method focuses approach thinking students learn deeper article practiced deep learning cycle curriculum programming language steps focused step processing learning deeper adopted task based mode online judge like designed problem repository teaching contents closely combined make students learn deeper practice proved based teaching model students programming skills greatly improved
recently reported interacting rnas regulate functions interacting phosphorylated proteins proteins addition except functional efficacy proteins readers still remains unknown therefore type regulate functional efficacy proteins interacting phosphorylated residues lung scc cell lines investigated effects mechanisms phosphorylated residue interacting results demonstrated regulating functional efficacy proteins thus referred protein functional effector distributed among nucleotides shared core sequences showed distinctive expression patterns scc cells core sequences showing consistent upregulation scc cells bound directly dependent key elements interaction critical functional efficacy basic activities lung normal cancer cells thus revealed novel type controlling functional efficacy proteins lung somatic cells elsevier rights reserved
micrornas small noncoding single stranded rnas emerged important regulators gene expression essential role vertebrate development different biological processes review highlights recent advances function mirnas roles bone remodeling bone diseases micrornas mirnas class small similar noncoding single stranded rnas emerged important regulators gene expression essential vertebrate development play critical roles different biological processes related cell differentiation activity metabolism apoptosis rising number experimental reports now indicate mirnas contribute every step bone homeostasis embryonic skeletal development maintenance adult bone tissue regulating growth differentiation activity different cell systems inside outside skeleton importantly emerging information animal studies suggests targeting mirnas become attractive new therapeutic approach osteoporosis skeletal diseases even though still major concerns related potential target effects need efficient delivery methods vivo moreover besides recognized effects cellular level evidence also gathering mirnas excreted blood body fluids potential endocrine functions thus represent suitable candidates becoming sensitive disease biomarkers different pathologic conditions including skeletal disorders despite promising perspectives work remains done mirnas serve robust therapeutic targets established diagnostic tools precision medicine skeletal disorders
ambient intelligence systems require natural personalized experience interacting services provided environment view interaction happen either pervasive way combination devices embedded environment using interface acting environment latter case interface embodied agent able involve users human like conversation establish social relation developing ambient system requires model user considers cognitive ingredients mental state also extra rational factors affect engagement attitudes paper describes multimodal framework recognizing social attitude users interaction embodied agent smart environment particular started analysis annotation humans used annotated corpus build framework recognizing social attitude multimodal results study show acceptable performance framework recognizing monitoring social attitude also compared results analysis human human interactions respect human interaction even level initiative subjects lower difference average number social moves significant thus showing subjects probably establish social relation agent
using data state national youth risk behavior surveys period find strong negative relationship cigarette youth smoking revisit relationship using four extra waves data results suggest youths become much less responsive cigarette since fact find little evidence negative relationship cigarette youth smoking restrict attention period conclude policy makers interested reducing youth smoking adopt alternative strategies
realization development goals also reflected construction industry sustainable consumption production patterns associated implementing developing reverse system construction site close supply chain construction materials initiating activities undertaken already construction site conditioning thereby possibilities resource recovery stages recovery process total costs hence type quantity quality waste affect cost collection significant item projects budget paper provides overview existing national recovery systems waste policies provide background case study crucial part research analysis three waste management scenarios particular construction project current approaches studied terms waste collection costs two extreme approaches created alternative usual waste management policy applied construction site approach reflection conceived waste management assuming segregation leads high costs waste processing approach turn assumes direct sales sorted waste lower prices also reverse within project thereby providing cost savings results show policy waste disposal encourages even forces implement reverse despite additional requirements general conclusions research confirm currently operating systems waste management site sustainable nevertheless still possible make eco efficient time proved analysis scenario also called economic authors published elsevier ltd
myelofibrosis chronic malignancy blood forming system caused stat signaling pathway small molecule inhibitors ameliorate related symptoms caused chronic inflammation anemia significant problem adverse prognostic factor third patients often worsened inhibitors inhibitor unexpectedly resulted reduction anemia patients phase trials current phase iii trials basis seeking regulatory approval studies determine improves anemia underway potentially leading expanded use development targeted therapies treating anemia related diseases
background aim evaluate characteristics cardiovascular complications large cohort adults diagnosed type diabetes years methods retrospective analysis patients diagnosed years patients diagnosed age years compare variables groups independent test paired test used normally distributed continuous variables mann test non normally distributed continuous variables chi squared test test categorical variables multivariable logistic regression used adjust confounders results young onset cohort age diagnosis years patients female ethnic minority background last visit age patients years diabetes duration years mean mmol mol patients obese hypertensive reach ldl cholesterol target cardiac event time last visit compared women men higher mmol mol mmol mol significantly higher rate cardiac events even adjustment confounders compared patients younger diagnosis years years less often obese compared first visit glycemic control improved mmol mol mmol mol time last visit compared older onset cohort young onset patients showed higher mmol mol mmol mol higher bmi last contact adjusted age diabetes duration cardiovascular risk factors difference cardiovascular events two cohorts conclusions diagnosis years important impact patients lives prevention measures essential also specific attention high risk group needed better achieve therapeutic targets
oral multi targeted tyrosine kinase inhibitor targets various receptors including vascular endothelial growth factor receptors received approval became standard treatment option first line treatment metastatic renal cell cancer phase iii trial showed superiority compared interferon alpha ifn alpha also shown activity second line treatment several trials combination trials various agents led considerable toxicity without improving efficacy alone causes significant side effects distinct profile diarrhoea hypertension skin effects hypothyroidism fatigue nausea special interest recommended dose orally daily weeks followed weeks treatment schedule alternative weeks week schedule schedule seems similar efficacy better tolerability widely used future intermittent treatment strategy stop remission induction progression showed efficacy smaller trials currently evaluated phase iii trial direct comparison first line treatment showed similar efficacy distinct toxicity profile data two phase trials showed also activity non clear cell cancer option due lack better alternatives currently immune checkpoint inhibitors shown promising results second line treatment tested number phase iii trials first line setting future show position first line treatment era immune checkpoint inhibitors
fractures second common presentation child abuse following soft tissue often difficult determine potential abuse child presenting non fracture without soft tissue injuries one hundred fifteen consecutive patients aged parts per thousand years presented fracture january june emergency department pediatric fracture clinic retrospectively analyzed statistical analyses carried non accidental fractures based age year years location presentation pediatric fracture clinic type long bone fracture number fractures patient demographics fractures patients reported non accidental trauma eighty patients first reported thirty two percent fractures children aged year fractures children aged years reported sixteen patients reported abuse multiple fractures patients aged year eight reported femoral fractures transverse fractures corner fractures occurred children aged year never occurred isolation reported four patients commercial insurance patients medicaid reported age less year multiple fractures corner fractures transverse fractures covered medicaid common factors associated reporting
common solution enhancing oil recovery oil reservoirs water injected reservoir purpose injection rates determined optimally control desired oil production accomplish reservoir management strategies goal achieved precisely modeling phenomena paper applicable algorithm modeling process oil reservoirs developed using proper system identification techniques help consider change inherent reservoir specifications addition operating point variations due injection rate also severe nonlinear nature reservoir consequently obtain adaptive model reservoir able reflect mentioned phenomena reservoir considered multi input multi output mimo plant several manipulated variables outputs mimic variables dynamics reservoir operational life recursive least square approach utilized proper factor sliding window length selection extract reservoir dynamic model content mimo model structure developed approach evaluated model known reservoir case study paper observed results demonstrate proposed method acceptable capability compared conventional line least square extended least square approaches lead auto model exogenous input auto moving average model exogenous inputs structures modeling dynamical behaviors reservoir employed powerful tool control optimization applications elsevier rights reserved
aims studies compared time trends incidence psychosis date results inconsistent showing decline increase significant change far know studies explored changes prevalence early risk factors aim study investigate differences early risk factors cumulative incidences psychosis type psychosis two comparable birth cohorts methods northern finland birth cohorts prospective general population based cohorts children followed since mothers mid pregnancy data schizophrenia narrow spectrum bipolar disorder psychotic features major depressive episode psychotic features brief psychosis icd collected nationwide registers including inpatients outpatients data early risk factors including sex place birth offspring parental age psychosis maternal education birth prospectively collected population registers follow reached age years results increase cumulative incidence seen due increase diagnosed affective earlier onset cases relatively women observed changes prevalence potential early risk factors identified parental psychosis significant predictor cohorts hazard ratios difference psychosis incidence dependent changes prevalence studied early risk factors conclusions surprisingly increase cumulative incidence psychosis also changes types found two birth cohorts years apart observed differences due real changes incidence attributable changes diagnostic practices early psychosis detection treatment
research intelligent procedure designed implemented based vibration signals detecting classifying prevalent faults internal combustion engine timing belt vibration signals timing belt captured operation six different states healthy tooth crack back crack wear separated tooth oil pollution signals processed three domains namely time frequency time frequency domains time domain signals transformed frequency time frequency domains using fast fourier transform wavelet transform respectively six statistical features extracted vibration signals three domains extracted features used inputs artificial neural network primary classification timing belt defects classification accuracy artificial neural network detecting classifying timing belt faults time frequency time frequency domains obtained respectively combining separate classification accuracies time frequency time frequency domains implemented using theory evidence classification accuracy based fusion time frequency domain classifiers time time frequency results frequency time frequency results also whereas combination results domains led accuracy results show proposed methodology detect classify timing belt defects high precision reliability failure occurrence
background increasing recognition risks associated patients diabetes studies investigated incident cause specific cardiovascular outcomes regard low fasting glucose general population objective hypothesized low fasting glucose associated cardiovascular disease risk cause mortality postmenopausal women methods test hypothesis used continuous incidence rates cox proportional hazards models participants womens health initiative fasting glucose measured baseline participants separated groups based fasting glucose level low results participants free cardiovascular disease enrollment mean age years caucasian african american asian hispanic median follow years graphs continuous incidence rates compared fasting glucose distribution exhibited evidence weak shaped association heart failure mortality predominantly due participants treated diabetes impaired diabetic fasting glucose positively associated outcomes associations low fasting glucose differed coronary heart disease significantly inverse stroke combined cardiovascular disease cause mortality null inverse significant heart failure positive significant conclusions fasting glucose upper range lower range significantly associated incident cardiovascular disease cause mortality elsevier inc rights reserved
purpose autologous matrix induced utilizing type iii collagen membrane compared alone focal cartilage lesions knee one two five years methods forty seven patients aged years mean defect size randomized treated either prospective multicentre clinical trial results improvement first two years subgroups progressive significant score degradation observed group functional parameters remained stable least five years groups two five years mri defect filling complete groups treatment related adverse events reported conclusions effective cartilage repair procedure knee resulting stable clinical results significantly better group five years
water resources assessment arid particular interest scientific terms also concept sustainable development study area basin represents remote arid area scarcity data measured effective porosity permeability revealed high sediments setting indicates favorable conditions groundwater accumulation opportunity recharge thus sustainability groundwater research approach based geological investigations several data layers gis environment including slope soil morphometric parameters structural data several specific sites suggested targets future groundwater studied basin contains four sub basins intensive drainage network morphometric parameters revealed potential surface runoff occurrence also groundwater recharge two investigated sub basins show high hazard degrees protected avoid flash floods estimated runoff volume single rainfall event reach hence management rainwater harvesting protection measures flash floods necessary future water resources management strategy based results multidisciplinary study proposed
maps solar irradiance readily available represent economic viability solar project particular location paper provides financial analysis different electricity maps internal rate return solar load displacement projects examine locations usa show maps differ substantially irradiance maps analysis includes scenarios derived following combinations three types solar concentrated photovoltaic south facing oriented optimize three project start dates three price projections grid connected systems central variation irradiance across much lower variation direct normal irradiance almost projects indicating irradiance alone poor predictor differences among locations including time use aspects play major role determining economic viability varies considerably even within single city modules optimize brings little benefit unless optimized greater west south elsevier ltd rights reserved
fluorescence fluctuation based methods non invasive microscopy tools especially suited study dynamical aspects biological processes methods examine spontaneous intensity fluctuations produced fluorescent molecules moving small sized observation volume defined confocal quantitative analysis intensity trace provides information processes producing fluctuations include diffusion binding interactions chemical reactions phenomena review present basic principles widespread fluctuation based methods discuss implementation standard confocal briefly examples applications address relevant questions living cells ultimate goal methods cell biology field observe biomolecules move interact targets perform biological action natural context life
excretion pattern arsenic species intake varies widely depending species ingested individual handling previously reported urinary excretion following single dose report excretion patterns subjects following days daily consumption either cod blue potato control followed period low diet groups total plasma urinary excretion increased significantly intervention confirming single dose study excreted apparently formed ingested total excretion cod blue groups respectively twice amounts single dose study indicating accumulation cod group rapid excretion single dose associated lower total blood less accumulation two weeks indicating lower accumulation blue group inorganic excretion increased significantly whilst strongly increased indicating possible toxicological concern repeated consumption elsevier ltd rights reserved
paper new neural network observer based optimal tracking control presented attenuate effect uncertainty position tracking multi motor adopting continuously function instead non differential dead zone model state space representation set using linear part function based state space representation optimal neural network observer used estimate uncertainties states combines optimal state feedback synthesis actual control law finally lyapunov theory utilized tracking error observed error neural network weights semi globally uniformly ultimately bounded simulation results validate effectiveness method
objective identify psychiatric diagnoses psychosocial factors associated intentional male genital self specific injury subtypes methods search medline embase psycinfo pubmed web science cinahl cases conducted december based related terms cases examined injury subtype psychiatric diagnosis psychosocial factors chi square analyses employed determine differences frequency factors across injury subtypes results data obtained cases genital combined common psychiatric disorders included schizophrenia spectrum substance use personality gender disorders chi square analyses revealed schizophrenia spectrum disorders occurred significantly often among auto compared self gender occurred significantly often among self auto significant differences emerged regarding psychosocial factors across subtypes however associations observed psychosocial factors psychiatric diagnoses although altogether commonly reported experiential factors reported psychotic individuals treatment noted among gender engaging auto conclusion clinicians consider diverse range psychiatric disorders psychosocial factors underlying elsevier inc rights reserved
essay examines role racial ethnic cultural bias cases analyzes cases court explicitly considered parents racial ethnic cultural background cases court factors clear opinion biases influenced decision briefly describes literature implicit bias demonstrate biases influence assessments despite best efforts make fair decisions drawing studies suggesting individuals reduce implicit biases effects decision making essay explores individual strategies institutional reforms address bias key points family court community influenced racial ethnic cultural backgrounds parents child implicit biases influence interpret parents behaviors preferences parenting styles favored middle class families disproportionately disadvantage racial ethnic minorities low income families best interests child standard increases risk intuitive biased assessments racial ethnic cultural differences necessary reduce bias individual strategies institutional reforms help reduce bias effect assessments decision making cases
introduce game trusted computation sensor equipped limited computing power leverages central computer evaluate specified function large dataset collected time assume central computer attack propose strategy sensor limited amount data counteract effect attack formulate problem two player game sensor optimal fusion strategy using non trusted output central computer locally stored trusted data attacker seeks compromise computation influencing fused value malicious manipulation data stored central computer first characterize nash game turn dependent parameters known players next adopt best response scheme iteration central computer reveals output sensor computes best response based linear combination private local estimate third party output characterize necessary sufficient conditions convergence along numerical results show convergence conditions relatively tight elsevier ltd rights reserved
propose bayesian approach person perception theoretical position methodological framework testing predictions experimentally use term person perception refer perception others personal attributes age sex also perception social signals direction gaze emotional expression bayesian approach provides formal description way perception combines current sensory evidence prior expectations structure environment expectations lead biases perception particularly evident sensory evidence uncertain illustrate ideas reference recent studies gaze perception show people bias perceive gaze others directed towards also describe potential application study perception persons sex bias towards perceiving males typically observed elsevier inc rights reserved
modern societies strong belief scientific progress unfortunately parallel partial occurs often mainly erroneous theories errors experiments prejudice selected publication positive results example methods introduced decades ago used without knowing underlying theories basic articles longer read cited cause incorrect interpretation results instance false use actual base excess instead standard base excess calculation number hydrogen ions leaving muscles raised idea unknown fixed acid produced addition lactic acid exercise erroneous theory led conclusion lactate anion strong acid buffer occur incorrect application method exclusion values evaluation measurements false calculations preparation authors reviewers always carefully read papers publication peer reviewers biased hypothesis author general problem selected publication positive results example sports medicine presence doped subjects groups investigated athletes reduce important investigators search original recent articles topic examine data authors reviewers read text thoroughly tables figures manuscript
recently service function promising network service mode modern networks however feasible implementation still difficult due need achieve functional equivalence traditional modes without performance increasing network complexity paper present configurable network service mechanism provide services network flexible optimal way firstly formulate problem network service design effective service chain construction framework based integrating software defined networking network functions virtualization model service path computation problem integer liner optimization problem propose algorithm named combine service function instances network utility maximum policy procedure achieve service node mapping defining service capacity matrix substrate nodes work optimal link mapping policies segment routing finally simulation results indicate average request acceptance ratio resources utilization ratio reach algorithm respectively upon prototype system demonstrated outperforms approaches provide flexible scalable network services
cell cytotoxicity syndrome strongly impaired granules released upon target cell contact contributing several defects typical severe immunodeficiency correction cell defects improve outcome hematopoietic stem cell transplantation proposed therapy investigated cell functions patient cord blood transplantation ability vitro treatment restore transplant strong defect cell mediated natural antibody dependent cytotoxicity ifn gamma production restored normal levels vitro treatment cytokine also caused appearance smaller lysosomal granules orientation towards target cell contact area thus suggesting general capacity restore cell effector functions moreover transplant although successful cell cytotoxicity resulted still partially impaired one year almost normal ten years fully recovered vitro treatment taken together results indicate wide capacity restore cell effector functions able reverse altered cytotoxic activity pattern cytokine production observed patient european federation immunological societies published elsevier rights reserved
evidence suggests dissociation negative affect binge eating extent dissociation impact experience around binge eating unclear women bulimia nervosa completed week ecological assessment protocol dissociation binge eating multilevel modeling used examine dissociation moderator binge eating greater time binge eating participants higher average dissociation subjects dissociation greater ones average within subjects trajectory characterized increase binge eating participants higher average dissociation trajectories characterized increases decreases binge eating dissociation greater ones average results support salience dissociation relation occurrence binge eating
migration psychiatric disorders cause stress adaptation processes differently men women empirical research scarce retrospective study turkish migrants native german inpatients depressive anxiety disorders matched age gender diagnoses compared using item instrument assessment migration related stressors gender differences prevalence stressors total sum stressors calculated compared migrants indigenous patients results showed higher global stress level migrants women men migration background regarding single stressors perceived loss status significantly prevalent pronounced men women whereas guilt feelings severe women turkish migration background compared men gender differences perceived stress taken account migration research
although child protective services child welfare agencies aim prevent maltreatment cases child abuse neglect common better understanding predictors aid preventing additional instances maltreatment previous study identified two interventions predicted psychotherapy parent related reduced risk temporary removal child parents related increased risk however counter expectations previous study identify specific risk factors related maltreatment current study hypothesized cumulative risk total number risk factors significantly predict maltreatment beyond intervention variables sample case files therapy parent related reduced likelihood believed relation temporary removal child parents maltreatment explained cumulative risk study also hypothesized relation temporary removal child parents mediated cumulative risk performing hierarchical logistic regression analysis first two hypotheses supported additional predictor psychotherapy child also related reduced chances however hypothesis supported risk significantly mediate relation temporary removal elsevier ltd rights reserved
controlled invasion maternal fetal interface crucial normal successful pregnancy otherwise pathological conditions pregnancy occur previous studies demonstrated unique long binding protein ligand natural killer group receptor uterine natural killer cells upregulated placenta patients present majority important role pregnancy aim present study determine role cell invasion closely associated occurrence present study expression levels collected section women normal pregnant women determined immunohistochemistry reverse transcription quantitative polymerase chain reaction western blotting effects cell line invasion mediated via cells underlying mechanisms investigated mrna protein expression levels significantly upregulated compared normal controls inhibited cells via regulation biological functions cells including downregulation expression cells stimulation production cytokines chemokines affect invasion cells important role pathophysiology modification biological functions cells affect invasion
objectives acute exacerbations recognized severe complication rheumatoid arthritis associated interstitial lung disease ild nevertheless role intensive immunosuppression ild remains elusive attempted evaluate clinical characteristics efficacy immunosuppressive treatment exacerbated ild methods clinical data including respiratory function imaging treatment prognosis retrospectively collected patients ild required hospitalization university hospital due acute exacerbation patients exacerbation patients results patients ild demonstrated significantly higher titers peptide antibodies compared patients japanese registry suggesting role adaptive immunity immunosuppressive treatment suppressed deterioration pulmonary functions improved ground grass consolidation particular patients less fibrosis computed tomography images showed better response treatment although five patients treated combination therapy including showed severely decreased lung volume intensive therapies provided good prognosis without average observation period days conclusions immunosuppressive therapy effective exacerbations ild severe cases low respiratory function intensive therapy including potential improve prognosis
geosynthetic structures created channel erosion protection offer environmental friendly benefits lower construction lifetime costs similar hard structures geotextile offers alternative channel erosion present study experiments conducted investigate working mechanism effectiveness installed beds rectangular plastic sand beds measured tests results showed presence led sediment deposition formation upstream downstream edges structure prevent bottom erosion near structure increase stability flow induced sediment beds protected
hospitals multiple data sources embedded systems monitors sensors number data available increasing information used care patient also assist decision processes introduction intelligent environments health care institutions adopted due ability provide useful information health professionals either helping identify prognosis also understand patient condition behind concept arises intelligent system track patient condition events health care system great advantage adaptable environment user needs system focused identifying events data streaming vital signs ventilation particularly valuable understanding patients condition work aims demonstrate process creating intelligent system capable operating real environment using streaming data provided vital signs monitors development important physician becomes possible crossing multiple variables real time analyzing value variation clinical importance
principle diode neutral point three phase three level inverter neutral line analyzed mathematical model main circuit established basis operation principle multi time calculation control strategy proposed reduce typical delay digital control improve system calculation accuracy lower inverter output voltage thd order improve inverter output voltage waveform logic external execution also proposed proposed control method verified inverter controlled processor dsp experiment results indicated thd inverter output voltage decreased considerably
objectives assessed effects cognitive behavioral intervention english field players organizational stressors emotions performance satisfaction design concurrent across participants multiple baseline single case research design three months post intervention follow method four high level female field players participated four phase intervention lasted weeks building observation phase baseline monitoring phase educating players facilitating acquisition cognitive technique phase iii encouraging integration technique sport performance phase questionnaires social validation used record participants emotions performance satisfaction throughout intervention three months post intervention follow conducted assess participants retention intervention effects results reduced threat loss elevated challenge reported immediately phase iii introduced emotions performance satisfaction increased emotions decreased throughout intervention social validation immediately post intervention end follow period indicated sustained adaptive changes outcome variables conclusions cognitive represents promising technique optimizing high level players challenge emotions appear linked increased performance satisfaction positive intervention effects retained period three months post intervention researchers examine effectiveness efficacy cognitive technique populations develop robust evidence base appraisal optimization sport elsevier ltd rights reserved
bulimia nervosa reliably classified subtypes based dimensions dietary restraint negative affect community clinical studies shown dietary negative affect subtypes greater test retest reliability concurrent predictive validity compared subtypes based diagnostic statistical manual mental disorders dsm although dietary negative affect subtypes shown utility characterizing eating disorders involve binge eating framework broader implications understanding restrictive eating disorders objective purpose study test concurrent predictive validity dietary negative affect subtypes among patients anorexia nervosa method latent profile analysis used identify subtypes based dimensions dietary restraint negative affect chi square multivariate analysis variance used characterize baseline differences identified subtypes structural equation modeling used test whether dietary negative affect subtypes outperform dsm categories predicting clinically relevant outcomes results results supported profile model replicated dietary negative affect subtypes latent profile clinically elevated scores restraint latent profile elevated scores restraint negative affect validation analyses showed membership dietary negative affect profile associated greater lifetime psychiatric comorbidity psychosocial impairment compared dietary class dietary negative affect subtypes outperformed dsm categories predicting quality life impairment year follow conclusions findings highlight clinical utility based dietary restraint negative affect informing future treatment matching personalized medicine strategies
present paper proposes model fuzzy logic control doubly fed asynchronous machine first mathematical model written appropriate reference frame established investigate results simulations order control rotor currents torque tracking control law synthesized using controllers stator side power factor controlled unity level artificial intelligent controls fuzzy logic control applied simulated performances compared classical controller results obtained matlab simulink environment show fuzzy control robust superior dynamic performance hence found suitable replacement conventional controller high performance drive applications
flexible coupling system moving rigid body flexible structures thus vibration suppression problem solved guarantee stability control accuracy characteristic model based nonlinear section adaptive control algorithm implemented suppress vibration flexible smart material driven mechanism using system modeling derived recognize dynamical characteristics closed loop stability analyzed based model also experimental setup constructed verify adopted method experimental comparison studies conducted modal frequencies identification active vibration control flexible active vibration control experiments include set point vibration control responses vibration suppression resonant excitation simultaneous translating vibration suppression using different control methods experimental results demonstrate controller suppress larger lower amplitude vibration near equilibrium point effectively elsevier ltd rights reserved
children represent population risk short size attraction animals face hands specific locations young children wounds often multiple half cases child animal dogs frequency argument episode occurs mostly child alone pet without direct supervision playing animal pediatric lesions infectious functional aesthetic goal work primarily make point principles surgical management animal children highlighting pediatric specificities animal require psychological surgical treatment adapted child specialized structure hospitalization general anesthesia frequent children suspicion abuse lead childs hospitalization even wounds justify monitoring surgical environment emergency surgery essential limit functional aesthetic consequences healing capacities child frequent lack morbidity allow conservative surgical treatment skin controlled healing first place immobilization drainage antibiotics complete surgery healing process however leads specific management remodeling phase growth psychological care child parents start time surgical treatment acute phase elsevier masson sas rights reserved
recognized eating disorder obsessive compulsive spectrum disorder disorder aim research analyze nutritional behaviors assessment risk authors developed questionnaire respondents participated used research method men women mostly meals per day women versus men however men women meals daily men versus women place birth field study differ terms number meals moreover observed number meals per day correlated time spent planning diet people meals per day often indicates spent per day planning diet comparison people meals respondents often meals company someone whereas indicated rule remaining respondents often consumed meals alone almost twice many men women never paid attention qualitative composition nutrition women followed diet often men versus indicated attempts losing weight around one third respondents suffered suffer eating disorders owing insufficient information essential conduct research determine characteristics high risk groups taking growing interest healthy lifestyle account need address problem public space
background emergency contraception known several decades dedicated products market close years yet unclear whether women particularly low resource countries access important second chance method contraception objectives review relevant policies regulations factors related access emergency contraception worldwide search strategy wide range gray literature reviewed several specific studies number online databases searched main results several positive policies regulations place emergency contraception products registered majority countries around world listed many countries essential medicines lists included widely used guidance supported donors yet analysis demographic data shows majority women low income countries never heard emergency contraception surveys find many providers negative attitudes toward providing emergency contraception conclusions despite decade international country level efforts ensure women access emergency contraception accessibility remains limited international federation gynecology obstetrics published elsevier ireland ltd rights reserved
boost converters indirect energy transfer topologies fastest transient response usually minimum possible output voltage deviation paper introduces practical mixed signal current programmed mode controller compared time optimal solutions provides smaller deviation lower current stress simpler controller implementation recover transients controller passes two phases first phase inductor current set proximity steady state value initial transient caused capacitor charging process reversed second phase voltage gradually recovered controller implements simple algorithm setting inductor current output voltage peak valley values transients based output current estimate obtained self tuning procedure operation controller verified simulations experimentally boost based prototype operating khz switching frequency comparison time optimal controller shows introduced programmable deviation system results times smaller voltage deviation limiting component stress
study examined west pacific differentiation mitochondrial cytochrome oxidase subunit ribosomal rna genes specimens examined samples locations west pacific ranging southern china results revealed comprises two major exhibiting divergence ranging demonstrated distribution ranging japan china divided three occurring south china sea korea determined endemic two endemic lineages occur island thus resembles several inter tidal species endemic waters nevertheless contrast inter tidal spp found separated populations instead divided northern southern probably yangtze river discharge limits gene flow northern southern populations
relationship facial shape attractiveness extensively studied yet studies investigated underlying biological factors attractive face many researchers proposed link female attractiveness sex hormones little empirical evidence support assumption present study investigated relationship circulating sex hormones attractiveness created prototypes separately averaging photographs women high low levels testosterone testosterone ratio levels respectively independent set facial images shape transformed toward prototypes paired resulting images way one face depicted female high hormone level one low hormone level fifty participants asked choose attractive face pair found low testosterone ratio low testosterone positively associated female facial attractiveness preference faces high levels additional experiment participants confirmed low testosterone ratio plays larger role low testosterone alone results provide empirical evidence attractive female face shaped interacting effects testosterone
chinese promising landscape plant measuring gene expression quantitative real time polymerase chain reaction qrt pcr provide valuable information gene function stably expressed reference genes normalization prerequisite ensuring accuracy target gene expression level among different samples however reference genes chinese systematically validated study candidate reference genes sand investigated qrt pcr samples including different tissues plants treated sucrose cold stresses data calculated four common algorithms delta cycle threshold delta stable tissue specific experiment cold treatment sucrose stresses least stable genes respectively comprehensive results showed top ranked stable genes across samples stability lowest experiments selected reference genes validated comparing expression profiles synthase gene chinese different samples results help improve accuracy gene expression studies chinese
agriculture largest employing sector involves total population participates pakistan side country facing shortage water population lives rural areas implementing schemes water areas feasible high expenditures less progress moreover supplying water areas time consuming unsafe expensive work therefore areas rainwater harvesting appropriate feasible technique paper represents study runoff pattern investigate potential water harvesting sites plateau pakistan techniques geographic information system remote sensing used water channels drainage line estimation runoff generation results revealed study area potential rainwater harvesting order accumulate store runoff generated annual rainfall
background recombinant human parathyroid hormone increasingly used treatment severe osteoporosis stimulates bone formation potentially enhance fracture healing objective study investigate effects versus radiographic outcomes treatment osteoporotic vertebral compression fractures methods total patients undergoing non operative treatment recent single level reviewed retrospectively thirty eight patients treated daily subcutaneous injection group whereas patients received weekly group except medications treatment protocol applied groups radiographic assessments included union status vertebral mid vertebral body height rates fracture site surgical intervention also compared two groups mean follow period months median range months results cox regression analysis showed reduced time union adjusted relative hazard ratio union rate six months treatment group group surgical intervention rate significantly higher group adjusted odds ratio change local degrees group degrees group paired test change mid vertebral body height group group paired test fracture site surgical interventions required group however two patients group eventually underwent surgical treatment symptomatic non union vertebral collapse conclusions retrospective study suggests enhance fracture healing improve union rate
psoriasis common disease affecting population produces significant impairment quality life immense burden families psoriasis associated significant cardiovascular comorbidity metabolic syndrome angiogenesis relatively researched component psoriasis key factor pathogenesis psoriasis also contributes development atherosclerosis vascular endothelial growth factor vegf established mediator pathological angiogenesis upregulated psoriasis possible patients psoriasis cutaneous angiogenesis marker systemic vascular pathology novel therapeutic target viewpoint study role vegf mediated angiogenesis cause cardiovascular events patients psoriasis explored
objective compare clinical outcome patients presenting symptoms seen doctor patients given treatment following diagnostic algorithm design randomized controlled trial setting hours service norway intervention women typical symptoms included trial time period september november randomized two groups one group received standard treatment according diagnostic algorithm group received treatment regular consultation doctor subjects women aged years mean age groups years main outcome measures number days symptomatic resolution results significant differences found groups basic patient demographics severity symptoms percentage urine samples single culture growth median three days symptomatic resolution found groups day four algorithm group regular consultation group free symptoms number patients contacted doctor follow period received alternative antibiotic treatment higher regular consultation treatment according diagnostic algorithm cases severe hospital admissions follow period conclusion using diagnostic algorithm safe efficient method treating women symptoms hours service simplification treatment strategy lead rational use consultation time adherence national antibiotic guidelines common disorder
syndrome prolonged disease course relapses requiring frequent visits prolonged steroid therapy long term concerns factors affect child families many domains functioning objective study assess multidimensional impact families children syndrome using family impact module methodsthis cross sectional study conducted paediatric clinic tertiary care hospital fifty cases steroid sensitive syndrome age group years included equal age sex matched healthy children taken controls baseline demographic factors including age gender education status modified socio economic status collected clinical variables cases recorded parent reported instrument measures impact paediatric chronic health conditions care hrqol family function mean scores compared among cases controls different predictive factors affecting family impact analysed resultsthe total score showed significantly lower scores cases mean score compared controls mean among individual groups lowest scores found two domains namely worry emotional function mean scores respectively although domains also significantly affected conclusion score evaluated cases parenting children significantly affect domains family functioning
one teenagers key developmental tasks engage new meaningful relationships peers adults outside family context attachment derived expectations self others terms internal attachment working models potential shape social processes critically thereby influence adolescents social emotional development social integration neural underpinnings developmental task remain largely unknown sought investigate functional magnetic resonance imaging asked adolescents ages years evaluate positive negative regarding either close adapted version established self trait evaluation task measures attachment obtained scores reflecting participants positive versus negative attachment derived self models means relationship questionnaire controlled possible confounding factors also obtaining scores reflecting internalizing externalizing problems borderline symptomatology results revealed participants negative attachment derived self model showed increased brain activity positive negative evaluation regarding self decreased brain activity negative evaluation regarding close bilateral amygdala bilateral anterior temporal pole anterior superior temporal gyrus left dorsolateral prefrontal cortex findings suggest low positivity self concept characteristic attachment anxiety dimension influence neural information processing opposite directions comes self versus close representations discuss results framework attachment theory regarding implications especially adolescent social emotional development social integration
paper presents novel approach demand side management dsm using individualized price policy end user receives separate electricity pricing scheme designed demand management order optimally manage flexible demands pricing schemes objective reducing peaks overall system demand way average electricity price individual user receives non shown paper approach number advantages benefits compared traditional dsm approaches demand aware price policy approach outlined paper exploits knowledge demand awareness obtained advanced infrastructure presented analysis includes detailed case study existing european distribution network dsm trial data available residential end users
somatic mutations exon highly specific confirm diagnosis polycythemia vera aim study develop method detection quantification exon allele burden nucleotide sequencing exon fragment carried use verify presence mutations dna sequences extracted clinical samples cloned obtained clones sequenced use reagents equipment applied usa sample containing mutation analyzed confirming presence mutations clones sanger sequencing quantification exon allele burden among negative patients high clinical hematological probability diagnosis mutation exon detected years old male patient detection quantification exon allele burden virtue using method patient carried three times august june results show allele burden increase twice months following patient data suggest increase number transformed clonal cells proposed method allows detecting carrying quantitative determination mutant exon allele burden monitoring efficacy therapy
vertical gate around structure shown one promising devices scaling beyond reduced area large driving current good gate control moreover emerging devices tunneling amenable vertical fabrication however past studies vertical channel devices focused regular memory architectures simple standard cells like inverters since naive migration regular layouts vertical yields little benefits identify several vertical efficient layout structures propose novel layout generation heuristics vertical channel devices also compare symmetric asymmetric source drain architectures different contact placement strategies layout efficiencies several structures vertical double gate lateral gate around presented experiments routing congestion estimation cell level chip level placement routing also presented observe even though vertical channel standard cells diffusion gaps lateral cells still benefit vertical architectures area vertically aligned top contacts asymmetric architectures area larger symmetric architectures extra diffusion gaps needed experiments indicate symmetric asymmetric architectures vertical channel devices likely density advantage lateral channel devices
correlation socioeconomic disadvantage child maltreatment long observed drivers association poorly understood sought estimate effects economic factors risk child maltreatment adjusting known influences using australian temperament project population based birth cohort individuals parents used logistic regression estimate associations childhood economic factors parental education occupation type housing retrospective perception poverty retrospective reports perceived child maltreatment physical abuse sexual abuse emotional abuse neglect domestic violence controlling demographic factors parental mental health substance use child health used estimates approximate proportions child maltreatment population attributable fractions theoretically preventable addressing childhood economic disadvantage economic factors associated types child maltreatment part associations diminished partially controlling con supporting hypotheses causal relationships jointly economic factors significant predictors physical abuse sexual abuse domestic violence emotional abuse neglect retrospective perceptions childhood poverty particular strongly associated forms child maltreatment sexual abuse accounting economic factors estimated child maltreatment jointly attributable economic factors findings suggest strategies reduce economic disadvantage likely hold significant potential reduce prevalence child maltreatment elsevier ltd rights reserved
binary sequences play crucial role cryptography classical approach binary sequences based computational complexity approach certain weak points thus last two decades new constructive quantitative approach developed since multidimensional analogs binary sequences called binary also important applications thus natural idea extend new approach multidimensional case extension started paper published since papers written subject goal present survey papers elsevier rights reserved
objective weight loss research focuses weight primary outcome often exclusion physiological psychological measures study aims provide holistic evaluation effects weight loss interventions individuals obesity examining physiological psychological eating disorders outcomes interventions methods databases medline psycinfo cochrane library searched randomised controlled trials systematic reviews obesity treatments dietary exercise behavioural psychological pharmacological surgical data extracted included study features risk bias study outcomes assessment treatment impacts physical psychological eating disorder outcomes results novel records studies met inclusion criteria evaluated review lifestyle interventions strongest evidence base first line approach escalation pharmacotherapy bariatric surgery severe complicated cases quality life common psychological outcome measure improved cases assessed across intervention types behavioural psychological lifestyle interventions weight loss led improvements cognitive restraint control eating binge eating bariatric surgery led improvements eating behaviour body image sustained long term discussion numerous treatment strategies assist people lose weight many effective short term quality life lesser degree depression anxiety psychosocial function often improve alongside weight loss weight loss also associated improvements eating disorder psychopathology related measures although overall eating disorder outcomes rarely assessed research sector collaboration required address significant overlap risk factors diagnoses treatment outcomes obesity eating disorders
melanoma one aggressive types skin cancer rapidly increasing incidence rate disease largely considered patients diagnosed metastatic melanoma survival five years despite recent advances anti melanoma available drugs relatively toxic responsive limited subset lesions currently topical pharmacotherapy demonstrated effective approach treatment various skin cancers also vitro testing melanoma cell lines murine melanoma models identified number relatively safe effective review described use topical pharmacotherapy treatment skin cancers melanoma treatment drugs targeting mapk pathway also discussed long non coding rnas therapeutics targeting associated pathways looks quite promising treatment melanoma moreover natural anticancer compounds reported anti melanoma effects also described present better understanding genetics epigenetics initiation progression melanoma needed identification novel biomarkers development targeted therapeutics melanoma elsevier inc rights reserved
past decades variety malicious attacks internet discovered attacks packets different network protocols due fast spread attacks difficult people copy immediately consequently packet filtering critical method prevent attacks however packet filtering software solutions satisfy demands contemporary network bandwidth paper propose gpu based multiple pattern matching algorithm filtering malicious packets using filter packet payload leveraging high parallelism computing power gpu experiments compare proposed algorithm different gpu implemented technologies sequence filter algorithm different platforms experimental results demonstrate proposed algorithm significantly enhances performance sequential algorithms
background aim describe relationship risk factors stress depression anxiety potentially protective factors pediatric headache related disability mindfulness resilience self compassion determine interest mind body skills training help reduce headache related disability methods cross sectional survey among adolescents seen academic neurology clinic reporting four headaches monthly using standardized instruments determine relationship putative risk protective factors physiologic markers inflammation tone headache related disability results among participants male average age years average headache frequency per month commonly reported trigger stress risk protective factor significantly associated headache related disability depression depression negatively correlated mindfulness resilience self compassion positively correlated stress sleep disturbance anxiety biomarkers tone inflammation correlated headache related disability depression strong interest learning skills like slow deep breathing practices supported smart phone application reduce stress negative impact headaches daily life discussion among frequent migraine headaches depression strongest risk factor headache related disability stress viewed headache trigger reported learn simple stress management strategies supported smart phone application help reduce headache related disability
mid organic registration data showed organic coffee farm operators women female rate increased research investigates impact significant increase womens coffee association participation among members two coffee associations mexico find female coffee organization members report high levels household decision making power likely male counterparts report control coffee income significant advances womens agency within household offset fact women experience significant time poverty engage coffee production bearing disproportionate share domestic labor women coffee producers view organizational labor third burden time reproductive productive labor time poverty experience limits ability fully participate coffee organizational governance consequently women leaders levels coffee businesses problematic limits womens ability fully benefit organizational membership women fully participate governance gain valuable business leadership skills associations active female members also likely develop maintain programs policies enhance gender equity findings indicate targeted agricultural development programs improve gender equity among agricultural involve creative ways ease womens labor burdens reduce time poverty order facilitate full organizational participation research findings fill gap existing studies agricultural global value chains demonstrating certified coffee depends womens paid labor within household also within organizations
many lung diseases result fibrotic fibrotic lung disorders divided diseases known unknown aetiology among unknown aetiology idiopathic pulmonary fibrosis ipf common diagnosis progressive character leading rapid decline lung function fatal disease poor prognosis limited therapeutic options thus ipf motivated many studies last decades order increase mechanistic understanding pathogenesis disease current concept suggests ongoing injury alveolar epithelium impaired regeneration capacity alveolar collapse finally response origin lung injury remains elusive diversity factors discussed article shown associated ipf alveolar epithelial type cells play key role lung fibrosis crucial role epithelial regeneration interaction fibroblasts known responsible collagen deposition illustrated whereas mechanisms collagen deposition focus many studies field awareness mechanisms disease currently limited biochemical imaging studies including quantitative assessments lung structure ipf animal models assigning alveolar collapse collapse crucial roles degradation lung resulting loss surface area dysfunctional cells mechanical stress trigger consists absorbed fibrotic tissue collapse
article analyses security discourses beginning self take board shift towards first sets developing highlighting limits cause effect approaches security increasingly becoming securing process generated new forms mediation agency capable fluid context approach methodology already existing forms agency set experimental practices securing using case study field digital policy focus community empowerment social technical developed applied city article concludes policy interventions today readily frameworks problem solving seen terms evolving adaptive life
mathematical model calculating steady non sinusoidal mode complex electrical network proposed taking account distribution overhead transmission lines parameters suspension geometry brand wires availability overhead ground wire cable way along route line based calculation complex network steady mode fundamental losses accounted caused positive sequence currents fundamental frequency total losses caused actual currents fundamental frequency high harmonic currents wires ground wires paper introduces example steady mode calculation results study effect loss electric power suspension geometry wires overhead ground wire cable
objective health messages tailored applying different tailoring ingredients among feedback adaptation experiment investigated separate effects tailoring ingredients behaviour auditory health furthermore moderating effect self efficacy participants design consisted four conditions generic health message served control condition applied using recipients first name feedback given personal state message adapted recipients outcome measures study consisted pre test questionnaire measuring fruit vegetable intake perceived difficulty performing behaviours indicating self efficacy exposure auditory message follow questionnaire measuring fruit vegetable intake two weeks message exposure results showed main effect condition either fruit vegetable intake moderation found vegetable intake self efficacy low vegetable intake higher listening message significant differences conditions found self efficacy individuals low self efficacy seemed benefit incorporating regarding vegetable consumption finding warrants investigation tailoring research
hydrogen promising alternative fossil fuel source clean energy production beneficial obtaining high production yield review basic metabolic pathways bacteria hydrogen production enzymes involved various hydrogen producing pathways microorganisms also focuses current status production fermentation commercially viable substrates agricultural residues use metabolic engineering attain certain physiological desirable characteristics producing microorganisms culture conditions types used reviewed major obstacles industrial production like low volumetric hydrogen production environmental impact identified review identified current limitations commercial hydrogen production suggested methods like use heat effluent recirculation reduce production cost copyright john wiley sons ltd
paper aims develop new method identification power quality events based discrete transform finite impulse response window type fuzzy kernel based support vector machine svm extracted features input signals svm classified using proper window function essential sine window used window function extract events features sine windows function four times faster default window function kernel design main part many kernel based methods svm using total accuracy classification enhanced present work use hybrid approach decreased extracted features size execution time total required memory optimized classification section simulation results revealed accurate classification execution detection classification nine types events overall accuracy proposed method comparable methods accuracy evaluated noisy conditions hardware platform developed evaluating proposed method based arm microcontroller assess accuracy method real conditions
prenatal development recognized critical period etiology obesity cardiometabolic disease potential strategies reduce maternal obesity induced risk later life largely overlooked paper first propose conceptual framework role public health preventive medicine effects fetal programming second review small growing body research august examines interactive effects maternal obesity two public health foci diet physical activity offspring results review support hypothesis diet physical activity early life attenuate disease susceptibility induced maternal obesity human evidence scant based review identify major gaps relevant prevention research characterizing type dose response dietary physical activity exposures modify adverse effects maternal obesity offspring third discuss potential implications interactions maternal obesity postnatal dietary physical activity exposures interventions mitigate maternal obesity induced risk among children conceptual framework evidence review future research directions offer platform develop test implement fetal programming mitigation strategies current future generations children elsevier inc rights reserved
animals engage associations bacterial understanding mechanisms host immune systems beneficial bacteria communicate fundamental question fields immunology two known binary relationship light organ bacterial consortium within specialized organ female reproductive system gland developed system allows immune cells migrate tissues including light organ association thought number roles management including recognition non symbiotic bacteria contribution nutrient source hypothesized recognize bacteria interactions pattern recognition receptors associated molecular patterns colonization shown affect bacteria binding behavior gene expression proteome indicating modulate host immune function also observed interacting residing bacterial community model host offers unique opportunity study innate immune system interacts binary mini review known role light organ association offer future directions understanding immune cells interact multiple types
speech comprising auditory visual component content processing pathways audio speech characterized visual component less understood work expand current methodologies using system identification introduce framework facilitates study visual speech natural continuous form specifically use models based acoustic envelope motion signal categorical visual speech features predict eeg activity silent results show models performs similarly predicting eeg visual regions respective combinations individual models provide improved prediction neural activity constituent models comparing different combinations find model incorporating three types features outperforms individual models models performs similarly model importantly outperform considering higher dimensionality model suggests data needed clarify finding nevertheless performance comparisons subject performances three individual models provides evidence suggest visual regions involved low level processing stimulus dynamics categorical speech perception framework prove useful investigating modality specific processing visual speech naturalistic conditions
probiotics play role digestion patients suffering digestive diseases consumers looking information effectiveness various diseases need find reliable sources answer questions eight internet resources presented provide quality information probiotics effectiveness common digestive diseases
background human cytomegalovirus infections found throughout body especially epithelial tissue animal model established inoculation strain hepatitis virus hev living rabbits specimens collected animals sacrificed half hours infection results virus found capable reproducing specimens pcr western blot severe inflammation damage found infected tissue viral protein detected high amounts mucosal epithelium lamina immunohistochemistry moreover strong positive signals lymphocytes macrophages lymphoid quantitative statistics indicate lymphocytes among cells increased significantly viral infection groups conclusions results showed hev efficiently infect rabbits vivo intestine loop inoculation present study successfully developed model vivo rabbit intestinal loop pathogenesis study rabbit model helpful understanding modulation gut immune system infection
frequency response measurements high frequencies shown provide valuable design tool various fields electronics measurements often challenging using commercially available measurement tools due relatively low maximum sampling frequency long measurement time effectively prevents frequency response based low cost applications fast reliable measurements required paper proposes use combined frequency applied pseudo random sequences method applied pseudo random excitation high frequencies injected device tested system response converted lower frequencies method provides low cost solution applied rapid high frequency measurements using modest data acquisition tools experimental results based high frequency resonator presented used demonstrate effectiveness proposed methods
paper studied surface quality damage morphology phase transformation stabilized cad cam milling subsequent sintering processes applied dental ray diffraction scanning electron microscopy sem used scan processed surfaces determine phase transformations analyse surface damage morphology respectively average surface roughness maximum roughness processed surfaces measured using top sem assisted morphology analytical software ray diffraction patterns prove sintering induced phase transformation induced phase transformation detected cad cam milling pre produced rough surfaces extensive fractures cracks simply sintering pre surfaces significantly improve surface roughness anova neither sintering surfaces effectively improve surface roughness anova best surface morphology produced milling sintering process achieving meets threshold bacterial retention smaller recommended larger produced visible surface defects study provides technical insights process selection achieve improved quality elsevier ltd rights reserved
software based thread level software technique parallel loops whose fully parallel semantics guaranteed time modern libraries allow handle arbitrary data structures desired feature comes high cost local store remote recovery times easier local store remote recovery unfortunately times critical path system paper propose solution performs local store constant time recover values time order number threads see solution together additional improvements makes difference noticeable parallelization non synthetic based applications real system experimental results show gain respect baseline system relative efficiency average respect implementation specifically tailored benchmarks used
background aims use exogenous hormones form oral contraceptives linked consistently risk crohns disease nonetheless clear contribute progression methods conducted prospective study female patients age identified inpatient outpatient care components swedish national patient register january december information current use obtained prescribed drug register starting july updated december primary outcomes defined first related surgery first steroid prescription used cox proportional hazard modeling time varying covariates estimate multivariable adjusted hazard ratios adjusted hrs results identified incident cases surgery among patients median follow period months compared adjusted hrs surgery confidence interval past users current users risk surgery increased longer duration use trend higher prescribed daily dose trend specifically women years use adjusted surgery association confined combination type estimated every patients receiving combination type oral contraceptives least year extra surgery required rate steroid prescriptions appear increase past current use compared patients taken conclusions nationwide analysis patients sweden long term use particularly combination type associated increased risk surgery among women established clinicians carefully evaluate monitor contraceptive options among women established
background aim study evaluate relationships cox genetic polymorphisms therapeutic efficacy non steroidal anti inflammatory drugs nsaids treatment ankylosing spondylitis material methods enrolled inpatients outpatients arthritis department university first hospital healthy people getting routine check ups september july cox genetic polymorphisms detected pcr rflp patients underwent medical treatment week follow treatment score differences basdai patients different genotypes treatment compared results terms cox gene polymorphism genotype allele frequency case group control group obviously different patients improved basdai scores received treatment furthermore efficacy treatment cox gene polymorphism associated conclusions cox polymorphism increase risk considered biological indicators prediction efficacy nsaids treatment
paper establish regularity criterion terms temperature fractional equations zero heat conductivity
propose algorithm electrical source imaging discharges takes data driven approach dynamics solutions method based linear system identification short time segments combined classical inverse solution approach whereas ensemble averaging segments inter segment variations averaging across approach explicitly models indeed even possible avoid need time consuming process containing discharges altogether demonstrate approach produce stable accurate inverse solutions experiments using simulated data real data epilepsy patients illustrative example show able image propagation using approach show applied imaging seizure data approach localized frequent seizure activity within margins surgeries led patients seizure freedom approach used planning epilepsy surgeries way localize potentially tissue
secure water supply essential human health challenges meeting demand great small island developing states water resources limited due social environmental constraints islands number factors constrained access fresh water including rapid population growth neglected water infrastructure ethnic tensions water increases past years sole reliance groundwater poor supporting electrical infrastructure within context case using rainwater tanks either predominant source augmentation existing domestic water supply explored effect historical drought events rainwater tanks examined water balance model developed various household scenarios reviewed determine reliability domestic rainwater tanks year period development model highlighted opportunities limitations used inform decision makers planners water resources management
background four free one care policy hiv aids related free services place china since however linkage human immunodeficiency virus hiv care yet achieved among people living hiv conducted qualitative study explore individual contextual factors influence linkage hiv care perspective young hiv infected men sex men msm highly centralized hiv care context china methods sampling used recruit hiv infected msm province depth interviews conducted march july thematic content analysis subsequently used data analysis results key barriers facilitators related linkage hiv care emerged participants narratives barriers included perceived healthy status low health literacy stigma associated receiving hiv care facilitators included awareness responsibility knowledge associated health literacy social support relying services provided center disease control prevention government related quality current hiv counselling testing service promotion cost placement hiv services conclusions order improve msm linkage hiv care china imperative improve quality current going counselling testing critical linkage support includes increasing supportive services among local systems designated hospitals community based organizations financial support hiv aids related testing medical treatments
substantial research indicated media violence induces short long term increases aggressive thoughts feelings behaviors recently neuroimaging techniques begun identify mechanisms driving changes important avenue neuroimaging tools address exposure media violence childhood affects brain development lifelong behavioral consequences review highlights neuroimaging research examining media violence exposure affects pediatric brain research limited evidence suggests prefrontal mechanisms controlling emotion behavior altered exposure violent media therefore long term increases aggression decreases inhibitory control due excessive media violence exposure result impaired development prefrontal regions however additional neuroimaging research necessary establish whether exposure media violence specifically shapes subsequent neural maturation optimize use neuroimaging inquiry imaging studies stand instead integrated traditional research paradigms establish complete picture effects future research employ longitudinal approaches better characterize long term effects high exposure violent screen media brain development particularly prefrontal limbic brain regions
frequently used treatment various diseases allergies gastric disorders especially cancer aim study evaluate possible potential methanol extract fractions pure compounds stems analysis carried conventional chromatographic techniques activity analyzed using assay mtt based assay fraction stems exhibited promising effect several human tumor cell lines glioma breast kidney lung total grown inhibition values ranging one active principles plant identified rare ester denoted compound demonstrated activity glioma kidney lung triple negative breast cancer cell lines results demonstrate stems produce active principles relevant potential
large scale relational databases normally large size high degree sparsity made database compression important improve performance save storage space using standard compression techniques take advantage relational properties techniques look nature data since semantic compression accounts exploits meanings dynamic ranges error individual attributes compression existing data dependencies correlations attributes table compression effective table data compression inspired semantic compression study proposes novel independent compression system utilising data mining model find frequent pattern maximum gain representative row order draw attribute semantics besides modified version augmented vector increase total throughput database compression algorithm enables granular suitable every kind massive data tables considering compression ratio space speed experimentation several large real life datasets indicates superiority system respect previously known semantic techniques
section basin designated basin represents half formed early due separation south american african final dispersal western approach fluid inclusion planes structures remote sensing data elucidate different scales main structural features kinematic indicators normal faults mainly deformation bands extension joints trend addition normal fault generated border units constitute dense zones deformation bands analyses suggest event occurred shallow basin levels temperatures degrees furthermore joints bands present mutually cross cutting relationships thus indicating numerical applied faults non faults joints deformation bands suggest occurrence event characterized variable direction extension sigma event probably started final fragmentation stages quasi perpendicular sigma trend caused one following phenomena stress ratio values obtained indicate possibility radial extension sigma approximate sigma perhaps response deformation partitioning due kinematic simple constraints along atlantic transform margin along oriented release normal faults local extension switch positions relation regional extension rotating degrees influence pre existing structures regional stress field thus spatial temporal relationships fault activity stress field development features basin contribute understanding brazilian margin elsevier rights reserved
one vulnerable world climate change india facing new challenges protect largest world adverse impacts climate driven changes study unsupervised classification density performed landsat images time periods years identify spatiotemporal evolution infer causes observed changes specifically influences environmental anthropogenic drivers changes discriminated correlating observed change patterns tracks erosion processes areas expected human influences assessed local stakeholders results highlight dynamic rapid changes characterized decreasing density mainly india erosion similar net erosion years remains limited relative documented high rate sea level rise density changes attributed increased salinity anthropogenic influences based interpretation spatial pattern density changes local stakeholders conclude zones accessible human activities significantly affected land cover changes management policies indian authorities important role played natural global drivers like sea level change affecting manage localized anthropogenic pressures elsevier ltd rights reserved
present article idea justice aim contributing terms identify combat morality underlying work performance basic education teachers concepts labour post philosophy worked order reflect light reference discipline basic education also served sustain argument applied idea justice field formal school education requires fight prejudice programs regulations drawn experts automatically result improvement idea justice action around equality bodies ideas work teachers proposed first instance start training idea justice equality bodies ideas central contribution term understood act state inability crossing division labour experts simple
flood modeling forecasting using hydraulic models computationally expensive high resolution large scale problems advent high performance computing numerical models obtain promising speedup using parallel computing resources paper message passing interface mpi based parallel shallow water flow solver using discontinuous method presented parallelization implemented static domain decomposition using single program multiple data design data transfer achieved using mpi implementation parallel solver tested using dam break tests field tests fully wet partially wet domains performance parallel speedup efficiency compared different mesh resolution cluster architecture statistical index maximum ratio cells total number elements introduced evaluate parallel efficiency performance index used guide choose number cores applications american society civil engineers
several studies showed efficiency natural techniques sludge water treatment plants brazil objective study evaluate system drainage drying geotextile using sludge two types water treatment plants laboratory experiments reduced scale following technical parameters project considered density application rate solids volumetric application rate drying different climate conditions drainage phase total volume liquid presented compatible quality standardized limits freshwater bodies classes according resolution national council environment drying phase possible obtain total solid rates values magnitude order obtained mechanical even critical drying conditions
event description mental based items also messages structure studied domains event participants object conceptualization less studied function syntax present theory syntax affects event similarity duration way systematically predictable interaction mass count syntax semantics test predictions six studies events count syntax give events mass syntax give advice taking less time frame count syntax give talk however result semantic shift orthogonal duration estimates results demonstrate semantic structure together systematically affect event author published elsevier inc
purpose main purpose review critically evaluate literature borderline personality disorder bpd published past years identify progress remaining challenges determine priority areas future research method systematic review literature last years undertaken results review yielded relevant abstracts applying inclusion criteria articles fully reviewed based articles implications future research clinical practice conclusion review indicated patients various benefited psychotherapy intensive therapies significantly superior less intensive therapies enhancing emotion regulation processes fostering coherent self identity important mechanisms change therapies extended patients bpd posttraumatic stress disorder research needed directed functional outcomes
paper presents novel multi channel optical filter structure proposed design based using set new formation named flower like arrangement shown instead using using recommended formation filtering operation achieved shown structure six filters four integrated obtained simplicity structure make usable wavelength division networks filters characteristics shape factor free spectral range rejection ratio designed adjusting coupling coefficients model structure signal flow graph method sfg based rule used modeling method discussed depth furthermore accuracy applicability method verified examples comparison modeling schemes elsevier rights reserved
background aims despite decades research occurring smoking depression cessation rates remain consistently lower depressed smokers smokers general population highlighting need theory driven models smoking depression paper provides systematic review particular focus upon psychological states disproportionately motivate smoking depression frame incentive learning theory account smoking depression occurrence methods searched pubmed scopus cinahl december yielded papers using pre established eligibility criteria identified papers focused clinical issues motivational mechanisms underlying smoking established adult smokers maintenance quit attempts cessation relapse elevated symptoms depression two reviewers determined independently whether papers met review criteria included papers qualitative synthesis results review identified three primary mechanisms underlie persistent smoking among depressed smokers low positive affect high negative affect cognitive impairment propose novel application incentive learning theory depressed smokers experience greater increases expected value smoking face three motivational states promotes goal directed choice smoking behavior alternative actions conclusions incentive learning theory accounts current evidence depression smoking behavior provides unique framework psychological mechanisms smoking maintenance among depressed smokers treatment focus upon correcting adverse internal states beliefs high value smoking states improve cessation outcomes depressed smokers
particles incorporate cell membrane proteins viral envelope explored possibility harnessing process generate expressing membrane proteins therapeutic interest studied potential tools treat different pathologies fas mediated apoptosis central maintenance cell homeostasis prevention autoimmune processes prepared express murine surface data indicate bearing induce caspase processing cytochrome release significantly cell death control vitro cytotoxicity blocked caspase inhibitor analysis application reagents treatment inflammatory arthritis vivo suggests expressing useful therapy autoimmune diseases rheumatoid arthritis excess fas expressing activated cells joint vehicle also membrane bound proteins maintain native conformation mediate biological activities
pluripotent stem cells popular model system investigating development tissue regeneration repair although much known molecular mechanisms regulate balance self renewal lineage commitment spatiotemporal integration responsive signaling pathways core transcriptional regulatory networks complex partially understood moreover measurements made populations cells reveal average properties underlying regulatory networks fine detail discuss reconstruction regulatory networks individual cells using novel single cell proteomics order expand understanding molecular basis including role cell cell variability within populations ways networks controlled order reliably manipulate cell behavior
construction safety important domains architecture engineering construction however studies rarely discussed safety issues perspectives employees safety requirements novel approach modeling reasoning functionalities applied semi automated identification safety requirements construction safety standards proposed approach based modeling document modeling techniques techniques model safety concepts requirements semantically rich human computer format features enable reasoning concepts requirements needed identify applicable safety requirements test cases used validate approach illustrate advantages validation results discussed conclusions directions future research given proposed approach benefit construction safety improving participants awareness safety requirements
physical education promoting life skills constitutes important educational objective aim study implement coping training program within regular evaluate effects coping stress among vocational students eight classes vocational school selected study four allocated intervention group four control group study examined intervention effects pre months follow compared showed improved coping skills pre follow stress decreased path analysis suggests indirect effect stress perception follow via improved adaptive coping skills findings support positive contribution development adaptive coping skills project shows physical educators translate psychological theory practice
shelf moisture responsive acetate adhesive tape investigated commercially available smart material low cost multifunctional humidity responsive scale structures laser ablation used cutting thinning tape enhance response water submerged show radius curvature lower laser additionally humidity response function angle longitudinal axis cantilever polymer orientation cut degrees respect orientation results tip rotation degrees enabling formation bending behavior tape functionalized magnetic nanoparticles used create four finger close underwater within minutes sample liquid cyclic humidity monitor also fabricated using tape strip shaped surface upon exposure humidity variations wiley periodicals inc
aim study perform systematic review etiology nasal bone fractures pubmed scopus search terms nasal bone fracture etiology cause used among excluded excluded abstracts read subsequently abstracts excluded full articles providing data etiologies reviewed finally papers incorporated analysis causes different adults children adults frequent causes traffic accidents sports falls children frequent causes sports traffic accidents collisions falls noticeable traffic accidents falls frequent adults children although sports collisions frequent children adults causes varied geographically frequent cause asia south america europe north america however traffic accidents frequent cause followed sports among sports injuries ball related sports frequent cause related sports contributed relatively small proportion efforts prevent children sports injuries primarily considered devices needed prevent caused traffic accidents especially north america
article address cyber technology facilitate reflective functioning patients present primitive self states fragmentation dissociation utilization text based information communication technology allow reflective space apart therapists explicit intrusion potential danger rejection help develop capacity reflection case illustration research findings discuss benefits challenges using cyber technology adjunct face face treatment
aggressive behaviors schools potential cause serious harm students emotional social limit ability achieve full academic potential prevention programs developed reduce childrens aggressive behaviors school settings provide interventions universal targeted level main aim randomized control study examine efficacy coping power adapted universal prevention program reducing childrens behavioral problems improving school grades nine classes participated students mean age months two elementary state schools italy study findings showed significant reduction behavioral problems improvement school grades intervention classes relative control classes study suggests coping power program delivered school settings universal targeted prevention levels multi prevention model teachers educators school psychologists learn set intervention skills delivered flexibility thus reducing complexity costs schools using multiple interventions
ability manipulate particles cells inside microfluidic channel critical enabling technology cell sorting applications however one major routine use clinical laboratory reliance inherent physical properties cells separation present microfluidic based activated acoustic cell sorting method rely specific binding target cells conjugated specific antibodies surface continuous cell separation using ultrasonic standing wave cells positive acoustic contrast particles migrate pressure nodes contrary air filled polymer strong negative acoustic contrast particles migrate pressure used selectively migrate target cells proof principle demonstrate separation cancer cell line suspension better efficiency moreover cell conjugates anti node hence better upstream affinity capture potential provide higher sorting efficiency technique expands acoustic cell manipulation possibilities offers cell sorting solutions suited applications point care
mammalian glutamate mitochondrial enzyme catalyzes reversible oxidative glutamate alpha ammonia reducing nad nadph links amino acid carbohydrate metabolism contributing cycle energy production ammonia handling redox homeostasis although one first major metabolic enzymes studied decades ago role cell biology still incompletely understood however growing interest novel emerged via duplication primates underwent rapid evolutionary selection concomitant prefrontal human cortex expansion also function currently sharp focus relates biology glial tumors used antibodies specific human human study expression human tissues results revealed expressed human brain kidney testis organs however distinct expression patterns emerged thus cells human testis strongly positive negative conversely showed high levels expression human liver hepatocytes virtually devoid human expressed steroid producing cells expression pattern matching cholesterol side chain cleavage system involved steroid synthesis similarly human ovaries placenta expressed estrogen producing cells addition enzyme also expressed cells lack endocrine function regarding human brain study cortical sections using immunofluorescence confocal microscopy revealed expressed cytoplasm gray white matter astrocytes within coarse structures resembling mitochondria additionally localized nuclear membrane subpopulation astrocytes vast majority precursors remarkably specific staining detected human cortical neurons different expression patterns emerged one pattern observed large cortical neurons morphology specific labeling cytoplasmic structures resembling mitochondria distributed either cell body cell surface close proximity end glutamatergic synapses another pattern observed small cortical neurons round dense nuclei specific staining found nuclear membrane detailed description observations functional implications suggesting flux used different cells serve unique functions presented
new approach constructing adsorption thermodynamics provides derivation rigorous thermodynamic relationships adsorption system particularly system adsorbent proposed expressions thermodynamic functions adsorption system form arbitrary control volume containing adsorbent gas derived derived expressions role adsorption played total content system control volume boundaries set appropriately quantity identical absolute adsorption
study evaluated effectiveness osteoporosis self assessment tool asians screening osteoporosis elderly male population area china advance bone used measure bone mineral density healthy males age years men scores assigned low risk moderate risk high risk group respectively scores measured dual energy ray absorptiometry different sites compared across groups bone mineral density lumbar left femur sites decreased gradually age increasing age screening sensitivity osteoporosis lumbar spine femur gradually increased whereas specificity decreased areas receiver operating characteristic curves index different age groups different sites therefore index demonstrated value screening osteoporosis men age years significant differences effectiveness observed among different age groups
multiple system atrophy demyelinating neurodegenerative disorder characterized accumulation aggregated synuclein inside precursors mature neurons dysfunction associated loss trophic factor production glial neuronal cells report recombinant wild type human uptake cell line reduced brain derived neurotrophic factor bdnf expression furthermore cells stably transfected human wild type associated mutant produces neuronal glial inclusions reduced bdnf mrna nearly qpcr levels another associated mutant also produces neuronal glial inclusions caused trend toward bdnf mrna reduction transfected cells suggests associated bdnf loss occurs response specific types treating cells food drug administration fda approved therapeutic multiple sclerosis bdnf downregulation cells also restored bdnf mrna cells treated recombinant measured qpcr confirmed increased histone acetylation chromatin immunoprecipitation assays showed increased histone bdnf promoter moreover cells treated acid classic histone inhibitor confirmed increasing histone levels increases bdnf expression data suggest associated histone inhibition stimulates bdnf expression cells raising possibility patients also benefit treatment elsevier ltd rights reserved
extracting ontologies relational databases extremely helpful semantic web vision however approaches context often drop many expressive features highly expressive detected database schema alone instead require combined analysis database schema data paper present approach transforms relational schema basic schema enhances rich constructs using schema data analysis techniques rely user verification features furthermore apply machine learning algorithms help ranking resulting features based user supplied relevance scores testing tool number databases demonstrates proposed approach feasible effective
effectiveness sand material controlling durability performance cement concrete investigated experimental program cement concrete specimens incorporating aggregate produced two water cement ratios leading moderate high level durability linear regression analysis applied evaluate rates significance change durability performance parameters concrete varied levels content ranging significant relationships performance parameters compressive strength water penetration resistance chloride migration coefficient resistance content found statistical analysis depending water cement ratio compared low water cement ratio concrete specimens contribution durability prominent concrete high water cement ratio paper also presents case study durability assessment going marine infrastructure project involving bay crossing suspension bridge findings obtained field conform output research elsevier ltd rights reserved
research generic analytical model voltage response time domain often cited various disciplines control engineering electronic engineering etc proposed model applied order type current excitation found beneficial various involved disciplines stated crucial basis development technology internet things due
summary aim study correlate indices cone beam computed tomography images bone mineral density bmd postmenopausal women quantitative indices used screen women low bmd purpose osteoporosis disease characterized deterioration bone tissue consequent decrease bmd increase bone fragility several studies performed assess indices images low bmd predictors aim study correlate indices images bmd postmenopausal women methods sixty postmenopausal women indications dental implants evaluation selected dual energy ray absorptiometry dxa performed patients divided normal osteopenia osteoporosis groups according world health organization criteria cross sectional images used evaluate computed tomography mandibular index computed tomography index inferior computed tomography index superior students test used compare differences indices groups correlation coefficient icc results statistical analysis showed high degree agreement measurements icc mean values lower osteoporosis group osteopenia normal patients comparing normal patients women osteopenia statistically significant difference mean value conclusions quantitative indices help screen women low spinal femoral bone mineral density refer postmenopausal women bone
response inhibition suggested dysfunctional obsessive compulsive disorder however process involves intentional cognitive control correspond automatic emergence thoughts behaviours usually reported patients present study excessive facilitation processes assessed using computerized mirror pointing task seventy six volunteers participated study including patients healthy controls administered participants score appropriateness sensorimotor adaptation mirror inversion computed initial deviation angle intentional movement results showed throughout trials score remained significantly abnormal patients comparison control participants analyses scores revealed clear tendency keep natural processing rigid mirror condition irrespective physical requirements environment patients showed strong tendency initiate movements per previously consolidated although sensorimotor mapping suggests tendency excessive facilitation processes studies conducted question using tasks sensitive cognitive processes spatial abilities elsevier ltd rights reserved
chemokines promising biomarkers immune activation inflammation evidence chemokine abnormalities schizophrenia relationship clinical factors remains inconclusive aimed understand chemokine related diagnostic differences clinical correlates using comprehensive panel studying large characterized sample adults without schizophrenia studied outpatients schizophrenia disorder healthy comparison individuals years age clinical obtained plasma levels chemokines assessed immunoassay schizophrenia tested chemokine adjusting age gender index current smoking status also examined whether age gender relationships differed diagnostic groups using logistic regression created chemokine index explored clinical correlates levels monocyte protein mcp macrophage inflammatory protein thymus activation regulated chemokine macrophage derived chemokine significantly higher persons schizophrenia hcs group differences reduced adjusting covariates linear combination levels positively associated age duration schizophrenia severity negative symptoms levels chemokines regulatory effects higher individuals schizophrenia particularly older chronic patients treatments aimed chemokine levels improve mental physical health among schizophrenia patients age published elsevier right
caloric restriction naturally occurring compound antioxidant anti inflammatory properties oxidative stress implicated etiology number neuropsychiatric disorders including generalized anxiety schizophrenia study investigated antipsychotic potentials murine models anxiety schizophrenia mice pretreated cellulose days subjected behavioural tests day activity determined using hole board tests anti psychotic property evaluated via induced swim induced tests although significantly reduce mean number head doses used hole board test significantly decreased mean episodes rearing without significantly altering total number upward steps test significantly reduced mean scores first ten minutes induced significantly decreased episodes total duration swim induced mice administration doses used study produced anti psychotic effects mice
soil scientists usa created large national database written soil profile descriptions follow defined set rules describing soil morphological properties interpreting soil descriptions skill requires considerable practice experience writing soil description straightforward visual representation soil profile written description difficult far generalized approach translating written soil descriptions visual representations propose novel procedural modeling approach inspired procedural models commonly used field computer graphics framework takes soil morphological data soil profile descriptions textual input translates visual features based parametric models models used generate two dimensional soil profiles generate three dimensional interactive models allow rotation scaling forms visual procedural modeling technique enables user generate soil profile visual representation small amount data images need stored generated needed
background main purpose study analyze correlation erectile function hormonal pattern year mortality risk using comorbidity index methods cross sectional analysis consecutive men attending sexual medicine mens health outpatient clinic july july conducted inclusion criteria age years old history pelvic surgery radio treatment releasing hormone analogues drugs variables including age height weight body mass index hardness score questionnaire hormonal pattern testosterone sex hormone binding globulin biochemical data prospectively recorded free calculated using formula low levels defined multivariate analysis performed relationship study populations variables year mortality risk erectile dysfunction low testosterone levels related entities affecting cardiovascular health diabetes metabolic syndrome heart disease validated tool predict mortality using items tool predict year mortality risk results one hundred eighty patients included mean age years old rate low levels found men univariate analysis variables age reactive protein related higher mortality risks according multivariate analysis variables age reactive protein related higher mortality risks conclusion age reactive protein related higher estimated year mortality risk using
study clarified factors affecting increase jump distance novice increased number steps approach run long jump discusses training task designed improve performance long jump twenty eight male students long jump take part sport activity regularly participated study performed long jump run ups six twelve take motions participants captured high speed digital camera two dimensional motion analysis students increased number steps approach run jump distance approach velocity increased horizontal take phase remained almost unchanged vertical velocity take contact time decreased change rate jump distance six twelve steps approach run positive correlation change rates approach velocity vertical velocity negative correlation change rate contact time previous study using athletes participants athletes increased jump distance increased number steps approach run present study however many students increase jump distance change rate jump distance wide distribution therefore divided students groups according whether participants change rate jump distance lower higher average change rate participants although groups increased horizontal velocity run participants low group increase jump distance vertical velocity take decreased additionally comparison athletes students lower vertical velocity take horizontal take novice thus learn proper technique take generate vertical velocity horizontal authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering university
air pollution topic currently studied address known health problems arise use electrostatic treatment particles sources small scale combustion systems presents advantages comparison possible devices study new prototype geometry based separating discharge electrode support gas stream path designed constructed tested gas stream small size diesel internal combustion engine used good behavior moderate time periods verified achieving average collection efficiencies thermogravimetric sem eds scanning electron microscopy energy dispersive ray spectroscopy analyses performed influence regulation power value discharge electrode effective length collection efficiency evaluated higher removal efficiencies linked higher power values higher discharge electrode effective lengths high impact operating time observed different discharge electrode geometries tested indicating increase collection efficiency power increased stainless steel electrodes opposite trend rod electrodes elsevier ltd rights reserved
purpose paper employ graphics processing units numerical solution large systems weakly singular integral equations means waveform relaxation methods cuda solver based different kinds iterations developed numerical results large systems arising semi discretization space fractional diffusion wave equations presented showing obtained speed published elsevier rights reserved
depression frequently encountered parkinsons disease non motor feature reported cause motor deficits neurodegenerative events experimental models studied effect chronic mild stress cms pre post pre post exposure mediated depression motor non motor symptoms oxidative stress inflammation brain derived neurotrophic factor bdnf levels related signalling molecules methyl phenyl induced neurotoxicity mice cms mice exhibited low neuromuscular strength length enhanced oxidative stress inflammation compared cms alone exposed mice diminished levels bdnf expressions erk akt akt regions compared alone exposure cms alone exposed mice showed anxiety related behaviour diminished expression serotonin transporter compared alone injected group post stress exposure mice exhibited lowest motor reflecting higher anxiety state greatest enhancement inflammation reduction protein expression stress cell signalling markers compared pre pre post stress exposed mice however pre pre post cms exposed animals vulnerable oxidative stress compared post stress experienced mice cms mediated depression motor non motor symptoms animals modulating oxidative stress various signalling molecules results suggested stress induced accelerate neurodegenerative processes progressive manner elsevier inc rights reserved
founded today eight offer engineering training france central africa college engineering technology city capital state south india remains true legacy educate student become person able take responsibilities real world students known engineering france consists blend theory practice based important collaboration industry three years basic courses every engineering fields mechanical engineering fluid mechanics materials engineering design manufacturing engineering electrical engineering computer sciences fourth year allows students choose courses following areas construction public works transportation energy information communication technologies courses taught industry professionals giving students accurate vision future jobs fifth year training focuses one semester engineer one semester project based research development activities collaboration industry projects past five years projects carried teams students working full time one semester supervised research credits projects performed companies small medium businesses large companies helping students better understanding industrial organisation applications also helps department develop strong links local industry collaborations school industry offer several advantages educational point view student motivation project management suited customer expectations methodology financial issues taken account hands approach development new materials product process design process improvements quality procedures etc projects examples development characterisation optimisation new insulation material based recycled support environmental compliance development oil cleaning system based flux steel sheets process modeling welding
background although eating disorder examination questionnaire version one widely used questionnaires eating disorders western countries research addressed psychometric properties japanese sample methods explored factor structure examined internal consistency derived scales japanese participants study convergent validity eating disorder related psychological measures study distinction derived two body image related factors psychological measures administered undergraduate students study study subsequently assessed two self report measures eating pathology eating attitudes test eat undergraduate students eating disorders inventory another undergraduate students participated examination relationships derived body image related subscales psychological measures self esteem scale beck depression inventory public self consciousness scale multidimensional scale results exploratory factor analysis identified four meaningful factors original four factors restriction eating concern retained however two factors shape weight concerns combined two different factors fear obesity self esteem based shape weight internal consistency derived four factors adequate relationships eat measures demonstrated convergent validity analysis distinction fear obesity self esteem based shape weight revealed self esteem based shape weight significantly associated measures assessing psychopathology related eating disorders conclusions study describes factors tested undergraduate students distinction two factors fear obesity self esteem based shape weight understanding psychopathology eating disorders adolescent japanese subjects facilitate future developments research treatment
investigated effects metacognitive mindfulness therapy stress management training hypertension symptoms depression anxiety compared control condition total female patients mean age randomly assigned one three conditions metacognitive mindfulness therapy stress management training control condition blood pressure symptoms depression anxiety decreased baseline post test follow group comparisons showed blood pressure symptoms depression anxiety decreased psychotherapeutic groups control group psychotherapeutic treatment hypertension reduced blood pressure symptoms depression anxiety positive effects observable follow later
achievement maintenance suppression cancer diagnosis associated improved outcomes hiv infected patients studies analyzed immunologic outcomes cancer diagnosis hiv infected patients diagnosis cancer urban clinic population included review hiv related outcomes hiv rna viral load cell count abstracted compared patients non aids defining cancers aids defining cancers four hundred twelve patients baseline hiv rna viral load data analyzed diagnoses patients higher median age years years higher frequency hepatitis median baseline lower patients cells cells patients likely suppressed cancer diagnosis median patients significantly higher patients months diagnosis higher months significantly patients times adjusted odds suppressed months times odds months compared patients adc diagnosis patients diagnosed urban clinic setting suppression immunologic recovery improved time patients highest odds suppression years following cancer diagnosis
novel story dog woman adopted son live century london meeting john famous found named river becomes travelling exploration discovery across world search plants time lot mind travelling finds equally realistic important visits cities meets characters besides since mother century counterparts said also travel time paper explore different ways travelling described novel purpose discovering extent follows travel general also examine travelling context period expansion british addition since one significant topics gender roles paper also focus differences male female male female time
article adopts computer simulation graph theoretic algorithm choose reasonable place convey drugs article use mathematical modeling computer programming solve problem transport drugs
micrornas mirnas class endogenous evolutionarily conserved small non coding rna molecules mediate process target gene leading translational repression degradation target mrnas series studies indicated mirnas play important role tumor initiation development progression study found regulation mir frequent event crc tissues compared tissues study demonstrated mir implicated crc metastasis transwell migration assay revealed elevated mir expression reduces crc cell migration moreover study showed suppression mir expression induces crc cell transition emt overexpression mir inhibits crc cell emt addition bioinformatics target prediction identified putative target mir knockdown mir shown expression furthermore overexpression mir suppressed expression consistent results also obtained regulation expression mir specified crc tissues moreover overexpression induces transition emt promotes metastasis crc cells decreased expression suppresses crc cells metastasis emt together results indicate mir novel regulator colorectal cancer metastasis data suggest mir implicated regulating epithelial mesenchymal transitions directly suppressing downstream target gene notch signaling pathway
frontal lobe dysfunction known associated impairment social behavior investigated link severe frontal lobe epilepsy antisocial trait studied four patients epilepsy involving prefrontal cortex presenting abnormal social behavior noninvasive investigations video eeg pet mri recording performed part assessment comprehensive psychiatric cognitive evaluation performed pre postoperatively frontal lobe epilepsy least years follow patients shared characteristic epilepsy pattern chronic severe prefrontal epilepsy daily seizures zone defined recording involving anterior cingulate cortex pfc posterior part orbitofrontal cortex early propagation contralateral prefrontal medial temporal structures patients fulfilled diagnostic criteria dsm antisocial personality disorder proved reversible following seizure control epilepsy involving prefrontal network associated antisocial personality hypothesize occurrence frequent seizures region prolonged period produces functional damage leading impaired prefrontal control social behavior functional damage reversible since successful epilepsy surgery markedly improved antisocial behavior patients results line previous reports impairment social moral behavior following frontal lobe injury elsevier inc rights reserved
study large size direct shear tests conducted determine interfacial shear characteristics sand geotextile three different normal stresses geotextiles used present study hybrid containing defined weight proportions polypropylene fibers subsequently interfacial shear characteristics hybrid nonwoven geotextile consisting solely polypropylene fibers sand compared analyzed different normal stresses initial higher shear stiffness sand polypropylene geotextiles observed corresponding sand hybrid geotextiles specifically higher normal stresses nevertheless contact efficiency sand hybrid similar sand polypropylene geotextiles surface morphology sand particles investigated based images obtained scanning electron microscopy sem quantitatively analyzed means degree methods elsevier ltd rights reserved
study presents new active building block analog signal processing applications namely fully differential current conveyor transconductance amplifier proposed circuit realized using differential difference current transconductance amplifiers unlike previous building blocks fully differential input electronic tuning capability obtained single new device proposed building block used realize universal filter example application pspice simulation results using cmos technology used confirm presented building block simulation results express proposed active building block used realize analog signal processing circuits
cerebral one common types vascular malformations central nervous system affecting nearly one people lesions characterized vascular channels single layer endothelium genetic linkage analyses mapped three loci three causative genes now identified allowing new insights pathophysiology focused protein take place blood vessel formation report expression patterns prenatal development adult human means immunohistochemistry western blot analysis obviously detected vascular endothelium precursor cells development also observed arterial endothelium neurons glial cells adult expression patterns suggest one arterial markers whether cause consequence altered vascular identity play role angiogenesis human brain development furthermore study described first time developing human published elsevier ltd rights reserved
small satellites limited payload attitudes sometimes difficult determine limited sensors alone wrong attitudes lead inaccurate map projections measurements require post processing correction study propose automated robust scheme derives satellite attitude observation images known satellite position matching land features observed image registered base map images scheme combines computer vision algorithms feature detection robust optimization geometrical constraints satellite observation applying proposed method uniform observations class small satellite satellite attitudes determined accuracy degrees comparable star satellite position accurately determined map projected images generated based accurate attitudes errors satellite position add systematic errors derived attitudes proposed scheme focuses determining satellite attitude feature detection algorithms applying raw satellite images unlike image registration studies register already map projected images delivering accurate attitude determination map projection proposed method improve image geometries small satellites thus reveal fine scale information earth
observe effects formula learning memory regulating effect gamma related anterior defective enhancer signaling pathway discuss clarify mechanism alzheimers disease sixty app transgenic mice randomly allocated groups model group group low dose group high dose group group another mice age genetic background allocated control group proper dosage drugs water given administration daily weeks weeks administration learning memory abilities mice group evaluated water maze test amyloid precursor protein app beta beta levels hippocampus detected enzyme linked immunosorbent assay gamma detected dual luciferase levels hypoxia inducible factor alpha hif alpha camp response element binding protein mrna expression measured western blot real time polymerase chain reaction ameliorate learning memory deficits app transgenic mice decreasing escape latency improving number platform crossing swimming speed decrease levels app beta beta activity gamma hippocampus alzheimers disease model mice regulate levels expression mrna improve learning memory ability inhibiting activity gamma signaling pathway one therapeutic mechanisms alzheimers disease
atlantic one largest top fish ecosystems north atlantic ocean mediterranean sea extensively recent decades however mediterranean sea mixing rates eastern central western basins yet fully finally resolved date electronic genetic markers still pattern movements population structuring basin essential background proper management used expressed sequence tag linked est linked explore population dynamics adaptive evolution mediterranean purpose est linked genotyped individuals mediterranean sea several methods used explore population genetic structuring estimate detect signals local adaptation bayesian clustering results indicated presence single cluster corroborated also correspondence analysis pairwise similarly two methods used detection loci reveal pattern suggesting presence selective pressure est simple sequence repeat used results suggest low level polymorphism detected study ascribed presence relatively conserved regions flanking genomic regions probably involved physiological responses local adaptation elsevier rights reserved
energy efficient medical equipment design current research trend medical science now scientists shifting focus toward energy efficient medical equipment design ecg machine commonly used medical equipment medical equipment consuming less power traditional counterpart whole medical system energy efficient finally reduces cost medical treatment work going design implement energy efficient ecg machine using low voltage digitally control impedance series terminated logic high speed transistor logic standard
basal marker expression triple negative breast cancers identifies basal like tumours thus group two prognostic groups however expression prognostic significance basal markers luminal breast cancers poorly described aim study investigate expression prognostic value basal markers egfr luminal breast cancer total fixed paraffin embedded breast cancer tumours characterized cohort norwegian women previously molecular subtypes using included study present study tumours expressing least one basal markers egfr defined basal marker positive cumulative incidence death breast cancer hazard ratio analyses used assess prognosis according basal marker expression total cases basal marker positive higher proportion basal marker positive tumours histopathological grade compared basal marker negative hormone receptor positive negative cases found better prognosis basal marker positive breast cancer compared basal marker negative subtypes combined poorer prognosis basal marker negative cases found histopathological grade tumours among grade
acting focus network security field intrusion detection technology plays important role different conditions feature selection methods intrusion detection directly affect efficiency intrusion detect system paper feature selection algorithm based relief relief sequential backward search relief proposed considering statistical correlation relief relief improved algorithm eliminates feature round iteration adopts result relief algorithm assessment criteria feature simulation results show proposed feature selection algorithm improves efficiency intrusion detection moreover provides correlation technique support
paper proposes protection method single line ground faults offshore wind farm fully rated converter based wind turbines proposed method uses current measured unit installed connection point fully rated converter based wind turbines unit protection current two adjacent nodes positive sequence current phase angle section identified comparing phase angles synchronized zero sequence currents adjacent nodes simulations offshore wind farm relay models carried using power system computer aided design electromagnetic transients including direct current
new task force postmortem imaging established annual meeting european society paediatric radiology postmortem task force separate child abuse task force covers aspects fetal neonatal non forensic postmortem imaging main focus task force guidance standardization non radiographic postmortem imaging particularly postmortem postmortem mri manuscript outlines starting point task force mission statement outline current experience short long term goals
background knee dislocations often require multiple concurrent ligament reconstructions involve creating several distal femur therefore risk tunnel convergence increased limited bone volume within distal aspect femur purpose assess risk tunnel convergence determine optimal reconstruction tunnel orientations multiple ligament reconstructions femur study design descriptive laboratory study methods three dimensional knee models developed computed tomography scans patients medical image processing software used create primary structures replicating surgical approach used multiple ligament reconstructions thereafter tunnel orientation varied surgically relevant directions determine orientations minimized risk tunnel convergence orientation anterior cruciate ligament acl posterior cruciate ligament pcl held constant throughout study orientation ligament tendon superficial medial ligament posterior ligament varied avoid convergence results high risk tunnel convergence observed acl tunnel aimed degrees axial planes aiming tunnel degrees minimized convergence acl tunnel tunnel convergence observed tunnel aimed degrees parallel tunnel avoid convergence pcl aimed degrees plane degrees degrees concomitant reconstruction aimed degrees degrees aimed degrees axial planes increased risk notch conclusion femoral tunnel orientations multiple ligament reconstructions need adjusted avoid tunnel convergence lateral side aiming degrees eliminated convergence acl tunnel medial side tunnel convergence avoided tunnel degrees tunnel degrees aimed degrees axial plane increased risk notch clinical relevance risk tunnel convergence acl pcl femoral reduced adjusting orientation respectively
last years seen identification pharmacologic approaches target bet proteins cancer treatment proteins essential role gene transcription regulation binding lysine residues histone activating gene transcription bet inhibitors tested preclinical models including pediatric malignancies several adult clinical trials ongoing since development new drugs pediatric cancer long lagged behind programs adults aim review show importance therapies pediatric malignancies support development pediatric oncology
uterine benign monoclonal tumors arising smooth muscle cells belong one common pathologies female genital system current oral contraceptives analogs ineffective limited use long term treatment although still much debate regarding etiology likely progesterone progesterone receptor play key role development profound importance progesterone female reproductive system led discovery synthetic progesterone receptor ligands poses activity ranging pure agonist activity trough mixed agonist antagonist activity pure antagonist activity development selective progesterone receptor modulators created new therapeutic options great potential number indications far ulipristal acetate approved emergency contraception progesterone receptor antagonist unique property compound termination pregnancy recently european commission ulipristal acetate pre operative treatment uterine superior efficacy ulipristal acetate versus placebo reduce excessive uterine bleeding reduce total volume prior surgery demonstrated moreover non inferior efficacy ulipristal acetate versus releasing hormone agonist reduce excessive uterine bleeding prior surgery uterine documented ulipristal acetate also characterized superior side effect profile comparison acetate terms serum estradiol levels proportion patients moderate severe hot treatment regarding safety profile except elevation liver enzymes treatment date serious effects reported issue endometrial effects compounds remains resolved although observation intrinsic agonist activity prevents endometrial proliferation suggest future use agents prevention endometrial hyperplasia promising applications including endometrial disease alzheimer disease long term contraception currently development
full potential plastic gear usage limited poor mechanical properties also equally poor temperature limits poor heat conduction properties cooling holes developed decrease amount thermal damage contact surface cooling holes promote increased stress tooth deflection thus exerting negative effect article compares various cooling holes plastic gear configurations proposes novel cooling holes thermal mechanical simulations consider specific aspects plastic gear performed main objective article verify best methods reducing thermal damage cooling holes results indicate best compromise temperature reduction mechanical properties new tooth geometry results also indicate simple variations cooling holes proposed improve tooth performance
location aware service imperative topic ambient intelligence recommends suitable utilities user based users location context however current several problems services last study proposes optimization based approach enhancing sustainability paper problems related optimizing system presented distinct nature optimization problem comparison traditional optimization problems subsequently described existing methods applicable solving optimization problem also reviewed advantages disadvantages method discussed combining multiple optimization methods study illustrated example finally opportunities challenges faced researchers field presented
distributed real time systems present particular challenge two key problems solved development first deployed protocols provide deterministic behavior enable predictable outcome second implementations protocols compliance stringent timing constraints stated protocols ensure runtime behavior remains deterministic particularly requires adequate isolation time critical protocols less preferential applications installed node paper present protocol framework challenges wireless sensor networks hardware platforms besides summarizing various mac protocols best effort real time capable protocols operating system functionalities provided paper presents comparative evaluations state practice operating system wireless sensor networks real time operating system results show protocols realized outperforms solutions execution times thereby providing evidence advantages real time systems
introduction chronic insomnia public health crisis affecting population annually typically presents one comorbid psychiatric organic conditions historical classification chronic insomnia secondary presenting comorbid condition resulted recognition treatment insomnia comorbid condition though critical model comorbid disease management chronic insomnia receives little public policy attention method conducted systematic review recent empirical studies review papers books government documents press releases articles pertaining classification epidemiology treatment physiology sleep insomnia comorbid conditions data located primarily medline psycinfo scopus pubmed databases objective results goal provide overview systems classifying insomnia available epidemiological data review theoretical models regarding etiology maintaining factors chronic insomnia along research complex bidirectional associations chronic insomnia various affective conditions conclusions thorough review literature propose several public policy measures initial step managing chronic insomnia united states include introducing nation wide multi modal educational awareness campaign sleep america increasing availability demand behavioral sleep medicine initially preferred treatment approach increasing use monitoring enforcement activities regulatory authorities false misleading claims supplements treatments insomnia adoption measures hope national interest healthy sleep evidence based treatment chronic insomnia elsevier rights reserved
proposed risk factor linked eating disorders anxiety current study examine domains contingent self worth potential moderators relationships maladaptive disordered eating anxiety using two waves data collection undergraduate females completed online surveys studys core constructs two points separated months bivariate level maladaptive positively associated disordered eating anxiety maladaptive appearance relationship contingent self worth interacted predict increases disordered eating neither interactive models predicted change anxiety findings highlight maladaptive construct related disordered eating anxiety interactive findings suggest targeting maladaptive contingent self worth appearance relationship prevention treatment efforts mitigate risk development increase disordered eating
background peer relationships important childrens mental health yet little known etiological underpinnings explore genetic influences childhood peer network characteristics three different networks defined rejection acceptance prosocial behavior examine impact early externalizing internalizing trajectories peer network characteristics methods participants children dutch generation birth cohort age mapped childrens classroom peer networks peer rejection acceptance prosocial behavior using mutual peer network genetic influences estimated childrens degree centrality centrality link dna using genome wide complex trait analysis preschool externalizing internalizing trajectories computed using parental ratings ages years results three network properties examined centrality emerged significantly heritable across networks preschool externalizing problems predicted unfavorable positions within peer rejection networks fewer mutual contrast children preschool internalizing problems actively rejected peers less connected within social support network conclusions finding significant heritability centrality taken preliminary evidence requires replication nevertheless role genes shaping childs position within peer networks additionally social network perspectives offer rich insights early life mental health trajectories impact childs later functioning within peer networks
quantum dot cellular automata based implementations reversible circuits got tremendous exposures last days due room temperature researchers serious need methodology realize area efficient counterparts reversible benchmark circuits work novel methodology named hybridization proposed synthesize reversible circuits using firstly reversible library consisting gates generated validate usability proposed methodology elementary module gate proposed extended realization gates multi control gates proper mathematical modelling several design metrics like effective area delay cost established counterpart gate reports less effective area less cost compared previous gate designs moreover layout reversible benchmark using multi control gate employed verify scalability reproducibility proposed methodology layouts generated tested simulated computer aided design tool
processor feature operating voltages processor circuits making increasingly vulnerable soft faults calls fault resilience techniques software hardware levels big data context assist software developers writing fault resilient big data applications propose tool helps focus efforts code regions data structures vulnerable soft errors understand numerical errors propagate program apply fault resilience techniques effectively achieves efficient generation error profiles leveraging predictive power boosted regression tree model use four big data kernels illustrate modular analysis mechanism show usefulness development numerical fault resilience big data
advancements cell transfer therapy act led use cells engineered tumor specific cell receptors rapid expansion obtained sufficient numbers treating patients however due massive proliferation cells close senescence exhibit phenotype also display increased susceptibility activation induced cell death previously shown tumor reactive cells undergo caspase independent cell death upon tcr antigen involves reactive oxygen species jun terminal kinase herein show large fraction human melanoma epitope reactive tcr cells exhibit effector memory phenotype undergo programmed necrosis upon tcr compared central memory subsets subset displayed increased expression genes involved cell death phenotype upon tcr confirmed electron microscopy higher expression receptor interacting kinases mediate also observed fraction cells rescued undergoing pretreated inhibitor tcr importantly pretreated tumor reactive cells also exhibited better tumor control increased vivo persistence transferred treat subcutaneously established murine melanoma thus likely outcome act improved interfering cell death pathway activated tumor reactive cells used immunotherapy
response eating disorders treatment thought predict later favourable outcome systematic review literature meta analyses examined robustness concept criteria used across studies define early response following preferred reporting items systematic reviews meta analyses guidelines diagnostic test accuracy methodology used estimate size effect studies synthesized data studies included meta analysis anorexia nervosa odds ratio early response predicting remission summary area curve auc bulimia nervosa odds ratio auc binge eating disorder odds ratio auc behaviour change accurately predicts later symptom remission anorexia nervosa binge eating disorder less predictive accuracy bulimia nervosa copyright john wiley sons ltd eating disorders association
paper constructs model determining optimal capacities water projects including limited dams flood control dams water transfer projects rainwater harvesting systems model helps analyze impacts institutional environmental technological changes capacity choices water projects analysis identifies conditions water reforms flood damages climate change lead larger optimal water project capacities also systematically analyze relation water project capacities water conservation technologies irrigation identify conditions paper implies design water projects separated institutional environmental technological conditions upstream downstream elsevier rights reserved
experimental investigations carried order identify portable device requirements vitro muscle tissue monitoring time based investigations specifications measurement system defined considering type amplitude excitation signals frequency range khz mhz impedance range omega omega requirements portable device structure proposed based magnitude ratio phase difference detection using gain phase detector fulfill requirements gain phase detector circuits inputs interface circuit proposed error lower
model cellular automata framework representing time evolution cellular systems appealing unlike many individual cell based models dynamically simulates changes cell shape size proliferation seen implementation modelling framework without consensus literature behaviour best represented additionally majority published model implementations feature proliferation order simulate certain biological situation important without analysis proliferation routines operate fundamental level method proliferation model uses separate cell phenotypes differentiate cells entered just left phase cell cycle presented demonstrated correctly predict logistic growth macroscopic scale accordance experimental evidence comparisons model simulations generalised logistic growth model provide interpretation shape parameter proliferation routine used shown offer somewhat predictable control proliferation rate important ensuring temporal consistency different cellular behaviours model results found insensitive inclusion active cell motility implications simulated proliferation assays towards problems cell biology also discussed
genetics investigated dogs presented small animal hospital faculty veterinary science university cohort dogs part four generation screened present screened dogs bilateral unilateral medial common lateral bidirectional risk similar male female dogs female male relative risk heritability screened population using threshold model genome wide association study cases controls using high density snp array indicated possible involvement chromosomal regions remained associated larger study involving additional cases controls candidate genes regions involved pathogenesis dogs elsevier ltd rights reserved
background angiotensin converting enzyme ace inhibitor induced angioedema rare albeit serious emergency result airway compromise potentially death treated currently agents approved food drug administration target ace inhibitor angioedema prevent inhibitors approved hereditary angioedema show promise alleviating inflammation associated ace inhibitor angioedema case report year old man presented emergency department swelling days starting hypertension despite receiving swelling progressed patients inhibitor ordered effort prevent arrival medication patient airway protection receipt inhibitor swelling dramatically improved patient successfully less hours presentation emergency physician aware case illustrates potential role inhibitors emergency setting treating drug induced angioedema prevent minimize mechanical ventilation time elsevier inc
paper presents nonlinear dynamic analysis structural system shape memory alloy members new time integration scheme proposed solving differential equation motion obtained system new implicit method assumed acceleration varies within time step terms series used increasing order acceleration expected responses better accuracy classical methods adopting assumption new family stable procedures obtained two dynamic loading cases considered numerical example structure analyzed behavior structure enhanced shape memory alloy connections findings display nonlinear dynamic analysis conducted structures showed efficient accurate also found shape memory alloy permits system recover initial configuration end deformation process recovery takes place without residual strains considerable amount energy elsevier ltd rights reserved
background general practitioners gps play key role care somatic psychiatric problems people diagnosed schizophrenia probable like health professionals gps free toward clinical practice gps sometimes interact clients diagnosed schizophrenia specialists accepting diagnosis times gps interact clients symptoms schizophrenia diagnosed case gps expected actively make diagnosis giving key role gps process care examining whether passive acceptance active usage diagnosis schizophrenia differential effects gps attitudes toward people disorder aims investigate gps views schizophrenia whether influenced schizophrenia label accepted actively used methods total randomly selected gps invited complete questionnaire views schizophrenia either reading description disorder making diagnosis without provided description accepting label schizophrenia given questionnaire results gps accepted label schizophrenia actively identified schizophrenia description similar views compared gps identify schizophrenia description used diagnosis actively frequently reported less frequently psychosocial factors causes disorder recovery need long term believed strongly discriminated medical hospital perceived dangerous kept greater social distance conclusion diagnosis schizophrenia however used associated views stigma education provided gps
present study examines discussion individuals regarding shared memory affects subsequent individual memory reports three experiments pairs participants recalled items photographs common household scenes discussed recall recalled items individually results showed discussion individuals recalled correct items incorrect items small non significant increases change recall accuracy information people exposed discussion generally accurate although accurate individuals initial recall individuals incorporated correct exposure items subsequent recall higher rate incorrect exposure items participants initially accurate became less accurate initially less accurate participants became accurate result discussion comparisons discussion control groups suggest effects simply product repeated recall opportunities self rather reflect transmission information individuals
background exclusive nutrition therapy using polymeric formula substantially attenuate intestinal inflammation crohns disease patients however mechanism suppresses inflammation yet fully understood aims examine cellular mechanism suppress inflammation investigate potential pathways enhance anti inflammatory properties methods arginine vitamin acid present along identified nutrient therapies tumor necrosis factor tnf exposed colonic epithelial cells used investigate immunosuppressive activity nutrients assessing effect cell viability cell activity chemokine response interleukin nuclear factor mitogen activated protein kinase kinase nitric oxide results cellular viability activity maintained nutrient treatments arginine vitamin significantly attenuated production arginine led phosphorylation blockade signaling components pathways reduction kinase activity enhancement production combining arginine optimal concentrations completely abolished response conclusions data indicate arginine vitamin suppress inflammation concentrations equivalent used mechanisms action mediated influencing cascades arginine promising option enhance effectiveness expand scope therapy treatment
subject rotation job rotation inside organizations seemed technically lots restrictions development adequate system rotation went need advanced study even possible restrictions versatility training employees implementation ideal system rotation passes stages development research study level employee versatility awareness discussion employees implementation proposed system feedback maintenance ideal sequence time rotation success project need multidisciplinary involvement areas manufacturing engineering industrial engineering human resources medical services manufacturing rotation tasks mean worker conduct two different activities different parts day change activity activity hours hours interval important consideration ensure different activities present risk body part tracing execution activity important factor production processes thus possible conduct appropriate levels training employees ensure safe sustainable processes terms workers health productivity quality
plasma density feedback control system established joint texas experimental text meeting need accurate plasma density physical experiments consists density measurement subsystem feedback control subsystem gas subsystem according characteristic gas system voltage amplitude control mode applied feedback control strategy accomplished proportion integral differential pid controller system quantity calibration gas injection adjusted responding change density signal carried experimental results shown discussed
work notable two counts first influenced final design suspension bridge second established first time form equal strength classical uniform flexible chain cable freely gravity supports equal strength form cable whose cross sectional area made proportional tension point tensile stress uniform throughout paper provide lives achievements interaction bridge follows commentary paper two related publications brief earlier history describe development suspension bridge present time finally discuss relations mathematical practical engineers commentary written journal transactions royal society
new generation electrical generator sets based variable speed generation concept diesel engine changes speed according load set optimum speed calculated according load optimality criterion minimum fuel consumption analysis dynamic behavior new concept shows new problems power voltage drops sudden increase load dynamical properties concept variable speed technology improved using energy buffer solutions concept energy buffer advantage disadvantage discussed paper
little known family risk factors intergenerational transmission psychological disturbance development health anxiety study investigated related concepts year old children exposed different maternal health status using family case control design three family groups included case children mothers severe control children mothers rheumatoid arthritis control children healthy mothers children mothers completed battery standardised questionnaires case children reported significantly higher level symptoms children mothers compared children healthy mothers significant difference childrens self reports three groups regard anxiety symptoms general physical complaints quality life contrast mothers reported children emotional physical symptoms mothers one control groups compared mothers healthy mothers mothers also reported visits general practitioner children past year findings suggest maternal weakly affects childrens report thereby strong risk factor development symptoms childhood however mothers severe seem children present often health care system therefore important target intervention adult patients
objective aim study develop vitro titanium oxide surfaces evaluate effect agents number putative periodontal pathogenic species methods vitro biofilm model developed sterile three agents chloride essential oils chloride applied min solution either without mechanical disruption viable bacteria colony forming units cfu measured quantitative polymerase chain reaction qpcr combined generalized model constructed determine effect agents viable bacterial counts surface results exposure solution resulted statistically significant reductions number viable target species included vitro multi species biofilm orders orders orders orders significant differences found counts tested bacteria vitro formed exposure antimicrobial agents whether application purely chemical combined mechanical disruption significance responded similarly exposure grown titanium surfaces spite described structural differences bacterial communities academy dental materials published elsevier ltd rights reserved
real time automatic regulation gene expression key technology synthetic biology enabling example synthetic circuits components operate optimal range computer guided control gene expression variety inducible promoters recently successfully demonstrated compared silico vivo three different control algorithms proportional integral model predictive control mpc controllers already used control gene expression zero average dynamics control technique used regulate electrical power systems chose experimental testbed commonly used inducible promoter yeast responsive promoter set two control tasks either force cells express desired constant fluorescence level reporter protein downstream promoter set point time varying fluorescence tracking using based experimental platform either glucose provided cells demonstrated mpc control strategies successfully regulate gene expression promoter living cells thousands minutes mpc controller track fast reference signals better higher actuation effort due large number input switches requires conversely controllers performance comparable achieved mpc controllers set point regulation
paper deals lack qualified professionals especially technical branches industry range possibilities spread knowledge know among students working age population department machine design university west taken first step reach goal created interactive learning materials using projects taken real practice primarily used students university west currently materials available full time students students hybrid courses nevertheless potential offer learning materials general public thus support amount qualified labour engineering branches west region also prospect create learning materials different branches choice made based demand support quality education regardless original profession age
testosterone deficiency commonly associated obesity metabolic syndrome type diabetes clinical consequences hepatic atherosclerosis testicular mouse non functional androgen receptor low testosterone develops fatty liver aortic lipid high fat diet whereas androgen controls testosterone treatment effects although underlying mechanisms remain unknown compared influence testosterone expression regulatory targets glucose cholesterol lipid metabolism muscle liver abdominal subcutaneous visceral adipose tissue testicular mice displayed significantly reduced muscle enzymes muscle liver abdominal subcutaneous visceral adipose tissue lipoprotein lipase required fatty acid uptake reduced subcutaneous adipose tissue enzymes fatty acid synthesis increased liver subcutaneous tissue coa acid synthesis associated insulin resistance increased visceral adipose tissue cholesterol efflux components apoe decreased subcutaneous liver tissue master regulator nuclear receptors involved metabolism liver receptor expression suppressed tissues except visceral adipose tissue whereas ppar gamma lower abdominal subcutaneous visceral adipose tissue ppar alpha abdominal subcutaneous testosterone treatment improved expression androgen receptor independent targets exploratory data suggest androgen deficiency reduce buffering capability glucose uptake utilisation abdominal subcutaneous muscle fatty acids abdominal subcutaneous lead uptake excess glucose triglycerides visceral adipose tissue liver arterial walls
multiple sclerosis leading neurological disorder young adults characterized loss demyelination inflammation neuronal degeneration show related protein mitochondrial protein activated primary cells exposed tnf alpha induced inflammation oxidative stress toxicity induced demyelinating mouse models inhibition hyper activation selective inhibitor translocation mitochondria reduces mitochondrial fragmentation stems necrosis primary exposed tnf notably types mouse models treatment significantly reduces loss mature demyelination attenuates number active microglial cells astrocytes yet effect differentiation precursor cells activation appears mediated pathway tnf alpha induced results demonstrate critical role hyper activation cell death suggest inhibitor hyper activation worth exploring ability slow progression elsevier inc rights reserved
cross sectional study patients myeloproliferative neoplasms found evidence secondary osteoporosis patients essential thrombocythemia vera increased risk fractures underlying mechanisms conducted study assess bone mineral density estimated bone strength global bone turnover patients patients evaluated cross sectional study dual energy ray absorptiometry dxa hip spine high resolution peripheral quantitative computed tomography distal radius distal tibia biochemical markers bone turnover including pro collagen type terminal pro peptide osteocalcin terminal cross linking type collagen bone specific alkaline phosphatase also healthy comparisons matched age height weight patient included control subjects patients comparisons almost identical iqr iqr respectively estimated bone strength measures highly similar two groups levels bone turnover markers within reference values patients results reveal evidence secondary osteoporosis among patients mechanism behind increased fracture risk patients remains unknown
heavy metal concentrations investigated liver kidney tissues liver kidney tissues fish exposed routine histological process concentrations metals included determined liver kidney tissue samples using atomic absorption levels liver kidney measured toxic effects heavy metals liver kidney tissues histopathological evaluation performed light microscope
paper present novel gpu based data structure spatial indexing based trees special type binary indexed trees data structure allows construction linear time updates computed time whereas point queries require constant time average unlike competing data structures area tables spatial data structure requires constant amount bits data element offers point queries property makes data structure ideally suited applications requiring indexing large data block storage large block sparse volumes finally provide asymptotic bounds run time memory requirements show applications new data structure useful
background induction treatment mild moderate crohns disease controversial purpose compare induction remission different doses corticosteroids active crohns disease data sources identified randomized controlled trials existing cochrane reviews updated literature search medline embase central november study selection included randomized controlled trials adult patients crohns disease compared corticosteroids placebo induction remission stratified low high doses data extraction primary outcome remission defined crohns disease activity index score bayesian random effects network meta analysis performed proportion remission data synthesis corticosteroids odds ratio interval high dose high dose superior placebo corticosteroids similar high dose effective high dose significantly superior therapy including placebo limitations randomized controlled trials use strict definition induction remission disease severity enrollment assess effectiveness treating mild moderate crohns disease limited conclusions corticosteroids high dose effective treatments inducing remission mild moderate crohns disease option among patients avoid steroids
domain name system traffic become rich source information security perspective however volume traffic security experience difficulties collecting retrieving analyzing traffic response modern internet threats precisely much research relating negatively affected dramatic increase number queries domains phenomenon scalable approach dependent volume traffic paper introduce fast scalable approach called detecting malicious behavior within large volumes traffic leverages signal processing technique power spectral density analysis discover major frequencies resulting periodic queries analysis allows detect sophisticated regardless techniques sporadic behavior even normal users traffic furthermore method allows deal large scale data utilizing timing information query generation regardless number queries domains finally groups hosts show similar patterns malicious behavior evaluated conducting experiments two different data sets namely traces generated real controlled environments large number real world traces collected recursive server server top level domain servers utilized traces ground truth result performed detection accuracy using large number traces able demonstrate scalability effectiveness terms practical usage finally detected unknown known groups false positives elsevier rights reserved
introduction intimate partner violence ipv estimated affect adult women united states alone ipv directly impacts womens ability use contraception resulting many unintended pregnancies stis review examines relationship ipv condom oral contraceptive use within united states two levels female victims perspective condom oral contraceptive use conjunction experiencing ipv aim male perpetrators perspective regarding condom oral contraceptive use aim study design systematically reviewed synthesized publications meeting study criteria published since aimed categorize results emerging themes related study aim results identified studies met inclusion criteria found studies addressed aim within identified three themes violence resulting reduced condom oral contraceptive use condom oral contraceptive use negotiation categorized ipv due condom oral contraceptive request perceived violence fear ipv resulting decreased condom oral contraceptive use sexual relationship power imbalances decreasing ability use condoms oral contraceptives reproductive found studies addressed aim studies cross sectional limiting ability determine causality ipv condom oral contraceptive use however studies find positive relationship ipv decreased condom oral contraceptive use conclusions quantitative qualitative mixed methods research demonstrated linkages female ipv victimization male ipv condom oral contraceptive use however additional qualitative longitudinal research needed improve understanding dynamics relationships ipv determine causality ipv intermediate variables contraceptive use negotiation sexual relationship power dynamics reproductive condom oral contraceptive use assessing relationship ipv reproductive elucidate barriers contraceptive use opportunities interventions increase contraceptive use forms contraception less partner influence reduce ipv reproductive elsevier inc rights reserved
wave energy currently resource potential make significant contribution energy mix order use conventional electrical generators mechanical interfaces used hydraulic systems air turbines electrical generator interfaces known electrical power take type used depends upon wave energy device brief description different power take offs provided show conventional rotary generators used wave devices advantages disadvantages highlighted paper direct drive systems overcome disadvantages additional engineering challenges overcome particular physical size mass current novel direct machine topologies discussed context challenges
people known propensity towards false memories considered less therefore important investigate individual factors related susceptibility false memory development deese roediger mcdermott drm procedure involves participants remembering lists related words tendency produce critical lures words originally presented strongly related studied words considered measure susceptibility false memories participants completed drm using neutral trauma related words along measures dissociation post traumatic cognitions cognitive style analyses indicated dissociation related false recall traumatic stimuli higher levels post traumatic cognitions associated decrease false recognition cognitive style related increase decrease false recognition implications research discussed
employees low levels work related self efficacy stand benefit stress management training intervention however low work related self efficacy enhanced benefits effect conditional employees also high levels intrinsic work motivation present study examined testing three way higher order interaction effects one hundred fifty three government employees randomly assigned intervention group waiting list control group group received three half day training sessions spread two half months findings indicated significant overall reductions psychological strain emotional group comparison control group furthermore significant higher order group control time work related self efficacy time intrinsic work motivation interactions reductions emotional certain time points experienced low baseline levels work related self efficacy high baseline levels intrinsic work motivation implications work related self efficacy theory research research practice discussed
universal feature replication positive strand rna viruses association intracellular membranes italian virus replication plants occurs vesicles derived mitochondrial outer membrane product encoded required targeting virus replication complex outer mitochondrial membrane plant yeast cells yeast saccharomyces cerevisiae used model host study effect cell survival death shown promote cell death decreases cell growth rate addition changed nature acetic acid induced cell death yeast increasing number cells necrosis concomitant decrease number cells programmed cell death judged measurements tight association membranes affected acetic acid treatment thus confirming peculiar independent interaction mitochondria yeast work proved yeast model organism study mitochondrial determinants type cell death response stress molecular pathogenesis rna viruses elsevier ireland ltd rights reserved
construction wastes increasingly civil engineering applications mainly concrete production base layers infrastructures however frequently fine grain portion recycled aggregates considered suitable applications instead recycled moreover value added utilisation recycled construction geosynthetic reinforced structures steep slopes retaining walls almost unexplored field research assesses feasibility using fine grain recycled filling material geosynthetic reinforced structures physical mechanical environmental characterization construction material direct shear behaviour interfaces material three distinct geosynthetics two one reinforcement high strength geotextile direct shear tests results shown fine grain recycled properly exhibit similar shear strength natural soils used commonly construction potential contamination groundwater recycled evaluated laboratory tests values total dissolved solids recycled provisions european council decision materials high values coefficients interaction geosynthetic interfaces parameter utmost importance design performance achieved results herein presented support viability using recycled filling material construction elsevier ltd rights reserved
prenatal hypoxia induces structural functional disturbances brain develop following postnatal cognitive behavioral disorders induced prenatal hypoxia preserved even adults oxidative stress key factor damage hypoxia hence relationship pro antioxidant systems plays important role development pathological adaptive processes induced hypoxia using studied expression four endogenous protein antioxidants superoxide dismutase superoxide dismutase hippocampal neurons adult rats subjected triple hypoxia days prenatal development found number cases prenatal hypoxia substantially modified expression endogenous antioxidants hippocampal neurons rats achieved adult age days postnatal directions changes however different different antioxidants areas hippocampus seems changes expression different antioxidants different areas reflects connection pathological consequences prenatal hypoxia adaptation processes induced hypoxia
high concentrations body cause toxic effects investigated effects structure function proteome cortical collecting duct epithelium vitro kidney cells chosen concentration kidney fold higher plasma mouse cell incubated containing media sensitive short circuit current resistance measured youngs modulus epithelium determined using atomic force microscopy effect epithelial structure assessed using scanning transmission electron microscopy immunofluorescence differences expression membrane proteins evaluated using proteomics bioinformatics exposure reduced transport resistance approximate effects half times ion transport resistance days respectively treatment affect sensitivity transport youngs modulus epithelium also unaffected however functional effects accompanied marked structural effects proteomic analysis revealed changes expression number proteins particularly mitochondrial proteins treatment profound effects structure function proteome model cortical collecting duct epithelium significantly however effects produced concentrations considerably higher likely encountered vivo wiley periodicals inc
tool friction welding relatively new solid state welding technology control conventional friction welding due unique welding tool structure paper closed loop control system developed predictive proportional integral derivative pid control method presented assist welding system producing appropriate interface temperature response difficult accurately detect temperature full range welding zone tool interface temperature detected wireless transmission technology initial experiments conducted derive qualitative understanding tool friction welding processes setting method adopted determine parameters pid controller examining capabilities predictive pid control paper focuses control effect characteristics welding temperature welding compensation strategy setting gaps along welding path gap affect distribution temperature experiments demonstrate temperature control strategy feasible tensile properties uniform along welding direction
background although anti egfr monoclonal antibody effective treating colorectal cancer occurrence severe skin disorders often therapy herein investigated retrospective chart review effect prophylactic oral combination skin treatment using incidence skin disorders tumor response metastatic colorectal cancer patients received patients methods total patients patients eligible consisting pre group reactive group rash adverse events graded according results occurrence rash grade significantly lower pre group reactive group significant differences occurrence adverse events observed two groups tumor response significantly different two groups confidence interval mean time treatment failure days days pre group reactive treatment group respectively conclusion prophylactic oral combined skin care reduced induced rash without significant influence tumor response
particle selectivity sediment deposited barriers importance predict sediment transport particulate pollutant load surface waters barriers covers degrees slope subjected presence absence simulated investigate sediment deposition processes results show steep effectively trap sediment grass barriers strengthen sediment deposition deposition order sediment particle sizes follows particle selectivity increasing grass covers clay particles similar deposition efficiency overall sediment implying effectiveness controlling soil nutrient loss contribution grass total flow resistance almost equivalent percentage grass cover steep slopes impact significantly decreases sediment deposition affects particle selectivity deposited sediment flow hydraulics kinetic energy stream power available surface soil contribute sediment deposition net deposition areas grass barriers imply rainfall effect sediment delivery barriers derives additional energy rather variation runoff hydraulics results help clarify effect impact sediment transport evaluate benefit decreasing sediment yield particulate nutrient load surface waters
sought examine trends cigarette smoking identify correlates smoking examine impacts smoking health related quality life hrqol among people living hiv ontario canada study sample included individuals receiving care enrolled ontario hiv treatment network cohort study self report data cigarette smoking hrqol demographic variables collected annual face face interviews clinical data abstracted participants medical records enhanced linkage public health laboratory database analyses included descriptive statistics generalized regression linear mixed effects modeling first interview participants current cigarette smokers smoking prevalence declined annually remained much higher prevalence general population current cigarette smokers likely younger male white indigenous canadian born single lower education heavy drug users current depression former cigarette smokers never smoked current cigarette smokers also significantly worse physical component summary beta mental component summary beta scores never smoked adjusting demographic socioeconomic hiv related clinical variables reduce burden cigarette smoking cessation interventions take account complex social economic medical needs people living hiv needed urgently
paper proposes optimal tuning proportional integral derivative pid controller using bacterial optimization algorithm enhance control performances stability automatic voltage regulator system new objective function designed necessary time domain specifications considered research work tuning gain parameters pid controller effectiveness proposed tuned pid controller extensively absorbed analyzing output performance stability robustness system superiority proposed approach demonstrated comparing results recently documented results swarm intelligence techniques differential evolution particle swarm optimization pso artificial colony abc algorithms many optimizing mol algorithm
important model reaction photocatalytic methanol dissociation drawn much attention reaction mechanism remains elusive using dft calculations investigate whole dissociation process methanol formaldehyde without holes aiming illustrate hole involved dissociation find dissociation methanol cleavage process likely thermally driven presence hole promotion barrier enthalpy change contrast subsequent bond cleavage follows cleavage mode likely driven great enhancement made kinetics thermodynamics holes introduced essential roles holes promoting dissociation identified kinds catalytic reactions facilitated holes discussed findings considerably broaden understanding photocatalytic chemistry
micrornas mirnas play key roles regulating toxicity tolerance plants typical low accumulating plant high tolerance despite importance mirna identified thus far study high throughput sequencing small rnas used identify mirnas differentially expressed response toxicity least mirna families individual members within families identified control treated roots among mirnas mirnas mirna families differentially expressed control treated plants among differentially expressed mirna families mirna families upregulated treated roots mirna families downregulated treated roots bioinformatics analysis indicated mirnas involved replication recombination repair inorganic ion transport metabolism transcription signal transduction mechanisms cell cycle control cell division chromosome partitioning rna processing modification roots results indicated specific mirnas tightly regulated toxicity roots play key roles tolerance
studies found provided diabetic renal damage present study evaluated effects different doses expression renal tissue type diabetes mellitus model rats possible mechanism underlying protective effect kidney methodsa high fat diet combined low dose streptozotocin used induce model rats diabetic rats treated end study urine blood samples collected measurement different indices light microscopy transmission electron microscopy used identify morphological changes renal expression protein assayed immunohistochemical staining whereas real time polymerase chain reaction used detect renal mrna expression treatment rats produced dose dependent significant reductions urinary albumin concentrations glomerular membrane thickness foot process fusion rate compared control model rats whereas renal expression protein mrna dose dependently increased treatment protects kidney model rats dose dependently adjusting renal expression
details within subjects study investigating effects stimulation self motion presence perceived interactive simulation study compared three conditions vibration constant vibration dynamic vibration results suggest constant feedback led significantly compelling self motion higher degree perceived
general purpose computing gpus emerging new paradigm several fields science although far applications tailored employ gpus offline computations steady decrease gpu increase link memory time real time applications using gpus high energy physics data acquisition trigger systems discuss use online parallel computing gpus synchronous low level trigger systems focusing tests performed trigger experiment components need analysing networking critical keep control fpga based network interface card enabling connection moreover discuss specific trigger algorithms thus benefit gpu implementation terms increased execution speed improvements particularly relevant upgrade highly selective algorithms crucial maintain sustainable trigger rates high elsevier rights reserved
gender especially status women certainly one salient identities world countries issues begin right education even earliest ages united states prevailing assumption women majority undergraduate graduate populations higher education threshold concerning access equity reached story gender however complex one article focus parallel notions significant progress domains women higher education paradox depending level depending women progress cases lack progress clear article review changes last decades address deeper issues institutional transformation emerging issues policy including gender
several years increasing interest use unmanned aerial vehicles acquiring image data low altitude considering cost effectiveness flight time conventional use former advantageous generating large scale accurate development uav imagery update large scale basic maps maps products used registration economic strategic planning basis maps maps produced example maps used building planning article presents usefulness based uav imagery upgrade basic map research compact non metric camera mounted fixed wing powered electric motor used tested area covered flat agricultural processing analysis carried programme due effect uav instability low altitude imagery use non metric digital cameras low accuracy gps sensors geometry images lower compared conventional digital aerial photos large values phi kappa angles therefore typically low altitude images require large along across track direction overlap usually result research obtained resolution meters horizontal accuracy basic maps used reference data accuracy basic maps estimated based study available reference sources result found geometric accuracy advantages final allow updating basic maps estimated update basic maps based uav imagery reduces processing time
transparent solar harvesting surfaces exciting new approach harvesting solar energy around buildings mobile electronics improve efficiency autonomy without impacting appearance recent demonstration ultraviolet near infrared nir selective light enabled transparent solar scalability flexibility aesthetic quality consequently question efficiency limits emerged new systems perspective theoretical efficiency limits systems reviewed practical considerations outlined approach limits nir selective harvesting single junction transparent constrained increases fully transparent devices light trapping deriving limits key material engineering challenges identified fully optimize transparent solar push towards commercial reality
branch bound known generic method computing optimal solution single objective optimization problem based idea divide consists implicit principle viewed tree search although branch bound first suggested land first complete algorithm introduced multi objective branch bound identified proposed rather multi objective branch bound algorithms proposed situation surprising contributions extensions components branch bound multi objective optimization recent example concept bound sets extends classic notion bounds mentioned developed first time fully defined paper describes state art multi objective branch bound reviews concepts components published algorithms mainly focuses contributions belonging class optimization problems received attention context linear optimization problems zero one variables mixed continuous variables papers aiming compute complete set efficient solutions discussed elsevier rights reserved
article examine gender differences teenagers year period using large nationally representative survey data since gender pay gap working life rather persistent finland necessary see whether gap persists teenagers although teenagers receive much income work adapt structures society years learn gender roles consumption education working life results reveal gender pay gap rather persistent finland particularly among year old teenagers among year olds gender difference income interactions gender socio economic indicators fathers education place residence persistent gender pay gap explained solely differences age group full time work teenagers nowadays rare finland work much even part time although rather obvious boys get higher girls external work allocation money parents seems unequal
purpose purpose paper examine specific stressors demands perceived control received support stress management strategies crisis managers organizations involved disaster response context large scale design methodology approach totally semi structured interviews crisis managers conducted five european countries analyzed qualitative text analysis method findings sample reported high demands various sources stress including event specific stressors group specific occupational stressors responsibility decision making justification failures dealing press media possibilities control perceived limited large scale organizational peer support played important role mitigating mission related stress effective stress management strategies reported crucial ensure successful crisis management need comprehensive stress management emphasized originality value stressors coping strategies first responders emergency services personnel previously examined corresponding research regarding professional group crisis management leaders remains scarce therefore study makes important contribution examining influential stressors within work environment crisis managers identifying starting points requirements stress management psychosocial support programs
research shown children learning disabilities less prone associative memory result impairments ability engage semantic processing however unclear whether observation true life events especially include emotional content across broad spectrum learning disabilities present study addressed issues assessing recognition memory like information children nonverbal learning disability children typically developing children participants viewed photographs common events family embedded episode either negative neutral consequence action childrens memory tested yes recognition task included old new photographs results showed three groups performed similarly recognizing target photographs exhibited differences memory errors compared groups children likely recognize photographs depicted cause emotional seen event associated remember responses errors children equally likely recognize causes seen photographs photographs generally consistent whereas participant groups likely recognize causes rather consistent results interpreted terms mechanisms underlying false memories formation different clinical populations children elsevier ltd rights reserved
spinal cord injury sci devastating condition effective treatments compound exhibited neuroprotective effects many neurodegenerative diseases however explicit effect mechanism sci still unclear adenosine activated protein kinase downstream protein play key roles energy resistance cellular protein homeostasis study determined effects sci potential relationship signaling pathway autophagy apoptosis determine effect sci recovery spinal cord model employed rats received treatment immediately following determined scores significantly higher injured rats treated staining revealed treatment significantly reduced loss motor neurons lesion size spinal cord injured rats compared vehicle treated animals spinal cord tissue assessed western blot reverse transcription polymerase chain reaction pcr immunohistochemical analyses days injury changes expression signaling pathway autophagy apoptosis proteins expression bcl elevated treated animals whereas expression cleaved caspase caspase bcl associated protein bax inhibited immunofluorescence analysis primary neurons treated alone combination compound inhibitor inhibitor revealed treatment inhibitors blocks increased expression cells increases portion positive cells taken together results suggest exerts neuroprotective effects sci regulating autophagy apoptosis mediated signaling pathway ibro published elsevier ltd rights reserved
aim investigate content serum microrna mir role screening retinal endothelial injury early diagnosis proliferative diabetic methods study included serum samples samples healthy individuals samples diabetes mellitus patients without diabetic non proliferative diabetic patients samples proliferative diabetic patients expression mir evaluated using real time quantitative polymerase chain reaction results serum content mir declined damage degree retina significant difference two groups receiver operating characteristic curve roc analyses indicated serum mir significant diagnostic value yielded area curve auc roc sensitivity specificity discriminating healthy controls auc roc sensitivity specificity discriminating healthy controls diagnostic threshold greater equal increase possibility content mir less equal possibility occurrence increased conclusion serum mir serve non invasive biomarker screening retinal endothelial injury early diagnosis
introduce new parallel pattern derived specific application domain show turns application beyond domain origin pool evolution pattern models parallel evolution population subject mutations evolving way given fitness function optimized pattern demonstrated suitable capturing modeling parallel patterns underpinning various evolutionary algorithms parallel patterns typical symbolic computation paper introduce pattern discuss implementation modern multi many core architectures finally present experimental results obtained implementations assess feasibility scalability
ambient intelligence technologies making daily life increasingly virtual boundary real world virtual world gradually computer games often played internet allows people games others even location paper analyzes trading card game two versions one version played paper based whereas played computer computer based supports remote play number enhancements providing special effects virtual two different versions useful analyze influence making future social interaction first investigate potential pitfalls introduce scenario based analysis adopts players personality exploit potential difficulties investigating insights influence analyze experiments augmented trading card game real player replaced player findings analyses show feeling essential make incorporated successful recently games concepts adopted order augment real world essential investigate influence introduced games future social interaction incorporate based variety game like features make interaction therefore insights described paper useful help design future social interaction
structural monitoring systems objective quantitative based management tool developed assist structure owners diagnostic prognostic decision making processes sensing technologies mature deployment permanent sensing arrays structures becoming popular resulting increasing volumes sensing data comprehensive data management systems needed host heterogeneous data sets associated structural asset management including structural information design inspection information massive amounts sensing data importantly data management system also provide functional secure means allowing software clients perform analytics data contained system paper scalable secure platform termed introduced management automated analysis sensing data includes hybrid database architecture maximizes query speed storing structural metadata relational database sensor data hierarchical data format repository multimedia files photos flat file system design presented followed description application manage process data associated long term wireless monitoring system installed road bridge illustrate effectiveness tracking performance monitored bridges study process extracting modal data road bridge sensor data stored using modal parameters update finite element model integral bridge owners decision making processes american society civil engineers
patients anorexia nervosa experience increased sensitivity risk social rejection aims study assess interpretation ambiguous social scenarios depicting risk rejection examine relationship interpretation biases clinical symptoms thirty five women anorexia nervosa healthy completed clinical questionnaires alongside completion task task required participants generate ambiguous social scenarios endorse best completion responses rated negative neutral positive patients endorsed negative interpretations fewer neutral positive interpretations compared healthy frequency endorsed negative interpretations correlated depression anxiety fear weight gain body disturbance negative interpretation bias towards social stimuli present women anorexia nervosa correlates clinical symptoms interventions aimed reducing bias improve illness prognosis copyright john wiley sons ltd eating disorders association
even though contraceptive coverage expands patient protection affordable care act reducing disparities contraceptive access provision requires providers assess patients reproductive life plans health systems work minimize institutional socioeconomic barriers article challenges providing equal access contraceptive care recommendations encouraging use effective contraception among reproductive age women reviewed
measurement based method evaluate efficiency antennas used microwave tissue imaging proposed method versatile principle applicable antennas operating free space two identical antennas employed one transmitting one receiving signal flow graph sfg developed two port network formed antennas medium electrical properties mimic tissue vary according application several measurements performed one antennas loaded known loads system equations constructed acquired data solution system produces efficiency antenna addition unknown parameters sfg efficiencies two antennas estimated measured simulated data verified comparisons
emotion regulation research common distinguish adaptive maladaptive emotion regulation strategies however little known impact interfering effects adolescents adjustment collected longitudinal multiple informant questionnaire data adolescents parents examine prevalence adolescents anger regulation profiles using latent profile analysis identified five anger regulation adaptive maladaptive low medium undefined profile first three profiles replicated year later one additional multiple another undefined profile findings supported assumption adaptive strategies compensate negative impact maladaptive strategies yielding negative psychosocial consequences particularly maladaptive profiles moreover different profiles related adolescents internalizing externalizing problems concurrently time results highlight importance considering adaptive maladaptive anger regulation strategies prevention psychotherapy
need better access evidence based parenting interventions widely recognized families actually participate parenting programs public health approach includes delivery parenting information via internet increase reach interventions dramatically however concerns web based information accessible families face greatest barriers accessing traditional face face parenting support therefore benefit online approaches study used cross sectional survey australian parents year olds investigate parents use internet access parenting information extent information useful parents range socio economic backgrounds results indicate majority parents use parenting websites social media parenting information users parenting websites tended parents younger children younger age child also associated using social media younger parental age female working spending hours online parents rated range modalities useful receiving parenting information particularly individually tailored programs self directed web based programs endorsed respondents higher risk parents likely likely endorse web based information sources lower risk parents almost equal access online parenting information among families different backgrounds conclude internet provides exciting opportunity delivering evidence based parenting support broad range parents including higher risk families
human immunodeficiency virus hiv infection dependence associated neural injury preferentially involving circuits little known however commonly comorbid conditions impact behavioral presentations typically associated frontal systems dysfunction sample comprised hiv uninfected hiv uninfected dependent hiv infected hiv infected dependent subjects participants completed self report measures frontal systems behaviors including impulsivity sensation seeking also underwent comprehensive neurocognitive neuropsychiatric assessments allowed detailed characterization neurocognitive deficits comorbid conditions including lifetime mood substance use disorders attention deficit hyperactivity disorder antisocial personality disorder multivariable regression models adjusting potential demographics comorbid conditions showed dependence independently associated increased impulsivity sensation seeking hiv infection greater however see synergistic additive effects hiv frontal systems behaviors global neurocognitive impairment relatively independent frontal systems behaviors consistent view constructs relatively underpinnings future research explore whether neurocognitive impairment frontal systems behaviors independently contribute everyday functioning outcomes relevant hiv elsevier ireland ltd rights reserved
mental health professionals increasingly aware need competence treatment clients related concerns however researchers recently sought explore efficacious treatments related concerns potential clinical judgment issues occurred due sensitive times nature client sexual concerns within therapy therapists required manage discomfort retaining fidelity treatment present paper explores clinician examples judgment errors result feelings discomfort specifically client use issues potential bias bias management techniques therapeutic implications discussed
using porcine model diabetes mellitus previously showed diabetes mellitus associated chronic increase blood brain barrier permeability cerebral cortex leading selective binding immunoglobulin deposition amyloid beta peptide neurons treatment inhibitor lipoprotein associated phospholipase alleviated effects investigation effects chronic diabetes mellitus pig retina revealed corresponding increased permeability blood retina barrier coupled leak plasma components retina alterations retinal architecture selective igg binding neurons ganglion cell layer thinning retinal layers due cell loss increased glial acidic protein expression cells treatment findings suggest chronic diabetes mellitus induces increased blood retina barrier permeability linked altered expression blood retina barrier associated tight junction proteins leading structural changes retina consistent diabetic additionally results suggest drugs vascular anti inflammatory properties beneficial effects eye diseases strongly linked vascular abnormalities diabetic age related degeneration
figure ground segmentation crucial preprocessing step many image processing computer vision tasks since different object classes need specific segmentation rules top approach object information suitable solve segmentation problems bottom approach problem faced existing top methods require much human work intervention meanwhile introducing human bias genetic programming require users specify structure solutions apply evolve conduct figure ground segmentation automatically accurately paper aims determine kind image information necessary evolve capable especially images high variations varied object shapes backgrounds therefore seven different terminal sets exploited evolve images four datasets texture databases increasingly difficult segmentation tasks selected testing results show proposed based method successfully applied diverse types images addition intensity based features sufficient complex images whereas features containing spectral statistical information necessary compared four widely used segmentation techniques method obtains consistently better segmentation performance elsevier rights reserved
background optimal number health workers appropriately allocated across different geographical regions required ensure population coverage health interventions health worker hiv care provision highest areas worst hit hiv epidemic kenya listed among countries experience health worker health workers per population high hiv burden hiv prevalence province set determine optimum number clinicians required provide quality hiv care services teaching referral hospital hiv clinic hiv clinic province cumulative client persons case presentation world organizations workload indicators needs used compute needs needs hiv clinic kenya january december people living hiv received hiv care services hiv clinic clinicians attending included analysis actual divided optimal staff requirement give ratios ratio indicated optimal less indicated suboptimal indicated optimal hiv clinic served staff various clinicians doctors clinical comprise approximately one fifth population clinicians excluding clinic manager engaged administrative roles consumes approximately one third time provide full time services operate maximum efficiency clinic therefore requires clinicians clinic therefore operates requirements conclusions assessment revealed severe shortage clinicians providing consultation services hiv clinic human resources managers rational planning training retention management human resources health using objective reliable means estimating needs
human prosocial behavior emerges year life challenging questions mechanism increasingly common claim prosocial behavior first years life neither result affected socialization article argue early socialization plays critical role developmental origins prosocial behavior support argument highlight conceptual perspectives empirical evidence influences socialization parents reports direct observation experimental studies conclude progress explaining origins human prosocial behavior depends fully specifying mechanisms socialization infancy human infants learn social experiences
introduce transactions libraries concurrent data structures transactions used ensure sequences data structure operations focusing access defined set data structure operations balance ease transactions efficiency data structures exemplify concept designing implementing library supporting transactions number maps sets implemented library offers efficient scalable transactions order magnitude faster state memory moreover approach stand alone data structure operations like put first class citizens allows execute virtually overhead speed original data structure library
drugs cheap effective generally safe improve outcomes however use consistent widespread manuscript reviews three commonly used namely related ammonium compounds oil pharmacology action safety agents evidence improving outcomes discussed addition detection outcome endpoints interest include patient comfort drugs studied found effective gastrointestinal good safety profiles insufficient evidence conclude whether improve rate predominantly baseline rates already high probably efficacy reducing time especially marked colonic offer significant benefit detection improving patient comfort future studies focus marked colonic greatest benefit seems lie
background cox expression induces carcinogenesis thought adverse prognostic factor gastric carcinomas prognostic value dna mismatch repair still controversial concerning junction comprehensive data regarding either factors available yet objective assessed expression cox adenocarcinoma junction relation patients survival various features design immunohistochemical studies using antibodies cox performed study population tumours data available patients mean follow time months results tumours cox negative showed cox positivity assessment cox expression features revealed inverse correlation depth tumour invasion number metastatic lymph nodes respectively correlation features demonstrated cases showed loss dna repair enzymes differed significantly cox positive negative cases kaplan meier survival analyses revealed impact patients survival cox expression status respectively conclusions expression cox junction seems prognostic effect impact patients survival associated favourable pathologic factors deficiency frequent cox negative tumours status impact survival patients outcome
background genetic regulation apoptosis cell proliferation plays role growth chronic lymphocytic leukemia common form leukemia western hemisphere although thyroid hormone receptor known play roles cell cycle potential involvement novel family member yet investigated methods quantitative pcr qpcr used detect expression patients healthy donors cells loss function sirna assays used alter expression levels effect cell proliferation apoptosis measured mtt based flow cytometry caspase activity assay pathway analysis used describe overview potential biological function downstream pathways dual luciferase reporter assay performed assess promoting effect myc transcription results qpcr data showed significantly expressed patients microarray analyses indicated biological function cell apoptosis cell proliferation associated sirna expressing cells exhibited slower cell proliferation rate underwent apoptosis compared control cells knockdown induced cells apoptosis independent regulation induced myc dependent transcriptional activation conclusion overall data suggest bio function cell first time gene therapeutic target
treatment bipolar disorder often results patients taking several drugs attempt alleviate residual depressive symptoms lead accumulation side effects new treatments bipolar depression increase side effect burden needed one treatment side effects bright light therapy shown effective therapy seasonal affective disorder yet extensively studied forms depression forty four adults bipolar disorder depressed phase randomized treatment bright light therapy low density high density negative ion generator weeks primary measure efficacy structured interview guide hamilton depression rating scale atypical depression supplement ads adverse events assessed using young mania rating scale systematic assessment treatment emergent effects outcome variables statistically analyzed using mixed model repeated measure analysis variance anova results showed statistically significant differences groups outcome measures study end point adverse events including switches rare research needed determine efficacy bright light therapy population elsevier ireland ltd rights reserved
proportional integral pid widely used industrial control applications digital pid complicated consists many stages paper introduces design analog pid controller using single active element implemented cmos technology pid tested using three structures two stage operational amplifier common source buffer stage folded cascade operational transconductance amplifier second generation current results taken three methods compared using frequency response transient response parameters
community academic research partnerships aim build stakeholder trust order improve reach translation health research limited empirical research regarding effective ways build trust study launched identify similarities differences among stakeholders perspectives antecedents trust research partnerships conducted mixed methods concept mapping study participants three major stakeholder groups identified rated importance different antecedents trust point likert type scale study participants community members health care providers academic researchers stakeholder groups rated authentic communication reciprocal relationships highest importance community members rated communication methodology resolve problems significantly higher academic researchers health care providers different perspectives regarding importance issues related sustainability importance communication relationships across stakeholders indicates importance processes involve exchange knowledge skills differences uncovered suggest specific areas attention skill building needed improve trust within partnerships research partnerships improve communication specific problem solving sustainability
large number scientific literature difficult search set relevant articles rank work propose generalized network analysis approach called star ranking model sorting based ranking result considered mutual relationships another classes keyword publication citation model propose two problem universal publication rank rank topic publication rank rank also study two simple based citation counting rank content matching rank propose metrics ranking comparison analysis two criteria value order conducted confirming predictions studying features results show proposed impressive given problem since consider query topic content publication citations ranking model
paper investigates stability principle underlying gait generated strict output following control hip joint angle first introduce planar like robot develop mathematical model equation motion design output following control relative hip joint angle linearized model second analytically derive transition function state error stance phase based state space representation discuss physical meaning also mathematically show collision phase always stable finally validity theoretical results verified numerical simulations
clarification anonymous participation generates change broader knowledge recovery processes offers improved understanding common factors underlie spiritual program insights counter confusion adoption freely available resources communities societies alcohol related disease burden high
paper present novel method based single phase active power filter series arc faults detection electrical installation reference current used starting point method tested large variety loads resistors vacuum rotary power supplies firstly proposed method validated simulation level using matlab software experimentally using hardware loop approach fpga iii prototyping board results obtained work show series arc faults successfully detected updating digital control arc fault detection functionality instead designing beginning arc fault detection specific device elsevier rights reserved
discrete cosine transform discrete sine transform members sinusoidal family transforms generalized signal flow graph type computation iii iii described based fast recursive numerically stable algorithm generalized signal flow graph represents unified approach fast iii iii computation suitable implementation universal chip
purpose review alpha alpha carbohydrate allergen several unique characteristics article discuss recent advances understanding alpha syndrome highlight data supporting role pathogenesis speculate immune mechanisms lead sensitization recent findings first described target ige individuals suffering immediate hypersensitivity reactions novel anti monoclonal antibody now clear sensitization associated mammalian meat allergy reactions mammalian products unlike traditional ige mediated food allergies reactions often manifest several hours following exposure although factors influence presentation multiple pieces evidence including recent work mouse model point fact sensitization mediated exposure certain hard increasingly aware globally widespread impact summary represents novel allergen several unusual clinical features recognized now multiple clinical presentation quite variable moreover efforts delineate mechanisms leading sensitization broader understanding type immunity
skin microbiota plays important role influencing immune response skin acting barrier potentially pathogenic microorganisms opportunistic pathogens staphylococcus key constituent normal microbiota human skin inflammatory response skin injury produces antimicrobial molecules selectively inhibit skin pathogens describe lactobacillus identified among hundreds lactobacillus strains exhibit anti inflammatory effect human keratinocytes vitro specific impact growth aqueous cell free extract used formulation tested randomized placebo controlled double blinded human pilot study healthy volunteers diagnosed dry skin treated four weeks study data shows extract induces skin protective microorganisms judged selective bacterial cultivation surface associated skin lower leg furthermore week administration extract significantly improved water loss value reduced symptoms data shows daily application extract topical product significantly improves microbial skin microbiota promoting growth species possess beneficial regulatory protective properties restoring natural skin microbiota leads significantly improved skin barrier function water loss decrease symptoms measured dry skin area severity index propose improving stabilizing natural skin microbiota specifically stimulating growth important novel concept manage skin diseases associated microbiota dysbiosis
prepared using standard solid state reaction dielectric properties samples investigated wide ranges frequencies temperatures means complex impedance spectroscopy substitution influences structural dielectric properties parent conductivity data doped samples fit law sigma omega sigma omega resulting fitting parameters indicated process neighboring sites conductivity regime followed relation activation energies doped samples respectively turn conductivity described small model energies doped samples respectively real part dielectric permittivity epsilon increased increasing temperature lowering frequency value epsilon also increased doping occurrence non type relaxation verified studied samples relaxation dynamics charge carriers samples examined within electric modulus formalism allowed determining probable relaxation time respective activation energy dielectric relaxation temperature range activation energy dielectric relaxation calculated doped samples respectively overlapping reduced plots modulus curves single master curve particularly higher frequencies temperatures concentrations considered suggests behavior dynamic processes slightly temperature content dependent finally impedance spectra characterized appearance modeled terms equivalent electrical circuits elsevier ltd group rights reserved
cytochrome enzyme thought play major part human metabolism potent specific vivo inhibitor administered six patients found mean levels rose baseline levels based observations inferred inhibition vivo minimal effects metabolism appears safe administered int
stem cells one key components tissue engineering tissue repair regeneration however studies necessary order provide suitable microenvironment stem cells differentiate thereby tissues carbon based nanomaterials carbon nanotubes graphene recently attracted much significant attention tools investigating controlling stem cell biology fate due remarkable characteristics including unique mechanical properties tunable surface chemistry high electrical conductivity review paper describe applications graphene stem cell differentiation consequently tissue formation vitro vivo conditions cytotoxicity graphene also addressed finally discuss potential challenges future directions applications graphene stem cell culture differentiation
motion non newtonian fluid analyzed curved channel long wavelength low reynolds number assumptions simulation digestive transport flow regime shown governed dimensionless fourth order nonlinear ordinary differential equation subject slip wall boundary conditions tested finite difference method based iterative scheme employed solution boundary value problem important phenomena pumping trapping associated motion investigated various values rheological parameters fluid curvature channel increase number found generate small eddy vicinity lower wall channel enhanced increase number shear thinning bio fluids power law rheological index greater number maximum velocity toward upper wall shear thickening bio fluids velocity amplitude enhanced markedly increasing number
substrate cycles also known cycles cyclic metabolic routes energy atp first described occur muscles brown adipose tissue popular example conversion phosphate back present study analyze large number substrate cycles human metabolism consume atp discuss statistics purpose use two recently published methods shortest method calculate samples substrate cycles respectively find unexpectedly high number substrate cycles human metabolism reactions per cycle utilizing reactions six different compartments analysis tissue specific models liver brain metabolism shows selective pressure acts uncontrolled dissipation energy avoiding enzymes belonging substrate cycle selective force particularly strong cycles high flux result thermodynamic principles
wave energy converters generally suffer low operating power factor due nature long wavelength water wave inductance electrical generator employed conversion process forced series capacitor converter connected generator load circuit prevent power factor degradation paper describes effectiveness new control strategy developed operation low variable frequencies corresponding nature water waves simulation results show proposed symmetrical duty cycle control strategy capable maintaining almost unity power factor required frequency range
improvement cultivar resistance key strategy control host specialized pathogen special feature pathogen systemic non homogenous delayed colonization plant resulting extended period latency result severity infection field difficult score becomes apparent crop maturity stages natural senescence assessment disease severity visual scoring harvested reflects genotypic resistance strongly affected stage plant overcome limitations developed qpcr method levels quantitative resistance genotypes field conditions specificity sensitivity two primer pairs targeting loci genome tested primers showed high specificity isolates primers exhibited significantly higher sensitivity detecting fungal dna stem tissue limit quantification dna field grown pre symptomatic plants best discrimination resistant susceptible cultivars based fungal dna analysis stem tissue achieved growth stage transition fungal vascular growth viable plants colonization stem tissues field screening data obtained qpcr growth stage confirmed results greenhouse testing thus relevance reliability assays determining cultivar responses field useful tool first selection elite genotypes improved resistance
background carotid femoral pulse wave velocity aortic measured using mri mri show good correlation significant consistent bias across studies aim current study evaluate whether differences mri accounted currently used distance measurements methods one hundred fourteen study participants recruited one groups type diabetes cardiovascular disease cvd without cvd cvd without control group participants underwent cardiac mri whole body angiography study participants also underwent aortic using mri performed using device medical west australia true intra arterial measured using used give results distance measurements significantly lower external tape measure mean mri significantly lower mri using inter arterial distance difference significantly reduced lost mri mean increased correlation age pulse pressure conclusion differences mri predominantly entirely explained introduced use simple surface measurements represent arterial path carotid femoral arteries
complexity setup coastal areas calls adoption scientific groundwater management techniques excessive withdrawal groundwater coastal zones lead depression water table associated hazards use rendering abstraction increased lift sustained regional groundwater sea level runs risk saline water intrusion even confined coastal uncontrolled groundwater development lead reversal freshwater gradient thereby resulting saline water coastal however several established methodologies control minimise problems associated groundwater extraction followed saline water intrusion study developed convenient easily analytical model coastal groundwater management aimed control intrusion technique includes withdrawal coastal freshwater means structures associated artificial recharge rainwater harvesting aided ponds recharge wells proposed methodology suitable specifically highly coastal areas significant annual precipitation good hydraulic conductivity aquifer low depth fresh groundwater case study model applied coastal zone district west india adequate efficiency methodology incorporated relevant conclusions drawn
janus kinase inhibitor ruxolitinib currently therapy indicated intermediate high risk myelofibrosis results clinical trials experience clinical practice shown ruxolitinib reduces myelofibrosis related splenomegaly symptom burden improves quality life measures addition ruxolitinib associated survival advantage compared placebo conventional therapy controlled trials however owing effects inhibition ruxolitinib associated decreases hemoglobin platelet counts particularly first weeks therapy close monitoring blood counts careful dose management particularly early course therapy essential avoid unnecessary prompt premature treatment discontinuation patients otherwise benefit continued therapy general starting doses dose reductions used recommended prescribing information based platelet counts dose escalation approach start therapy recommended patients platelet counts possible maximum tolerated doses maintained extended treatment avoided prevent lack loss treatment responses individualized dosing approach key long term treatment success
online genetic improvement ability evolve adapt inside target software system enabling improve runtime without external dependencies human intervention recently developed general purpose tool enabling online genetic improvement software systems running java virtual machine tool embedded inside extant software systems runtime enabling systems self improve adapt autonomously online present tool describing architecture focusing design choices possible uses
work optical fiber size effects performances modified fiber zno relative humidity sensor experimentally investigated simple controlled chemical method line monitoring used prepare different fiber waist diameter long length precisely competition behavior sensor performances varying fiber waist diameter studied find appropriate size maximizing fields obtained results revealed wave absorption coefficient gamma enhanced times compare bare fiber proposed optimum fiber diameter also high linearity fast recovery time obtained proposed fiber waist diameter applicable features proposed sensor allow device used humidity sensing applications especially applied remote sensing technologies
contemporary research documents various psychological aspects economic decision making main goal study analyse role mood maintenance hypothesis financial markets refers peoples tendency maintain positive mood states implies positive mood associated less critical thinking reduced information processing yielding three behavioral effects blue resulting stronger negative reactions bad news good mood periods day leading stronger positive reactions good news bad mood periods iii shallow thinking producing stronger reactions kinds news good mood periods employing daylight duration changes measure onset recovery symptoms seasonal affective disorder sad mood test role mood reactions recommendation find results notably negative stock price reactions recommendation significantly stronger daylight increasing periods alternatively periods characterized low rates onset high rates recovery sad magnitude effect increases longer event windows
monitoring pressure critically important part management however clinical predominantly involves unable detect variations response posture changes muscular effort deep wide range activities playing high wind resistance instruments wearing swimming addition eye example usefulness hour increased nocturnal assessments included side prone sleeping rather limited posture continuous monitoring allows involvement full range sleep non sleep activities provide ideal method quantifying frequency duration degree episodes elevation addition physiological pathological circadian rhythmic variations due treatment apart degree exposure episodes elevation genetic influences family history factors associated increased susceptibility develop progress pathology include age race type degree error systemic hypertension migraine dispersion syndrome syndrome obstructive sleep syndrome diabetes medication interactions side effects information combined details relating episodes elevation appears likely strong basis detection diagnosis treatment review examines limitations methods longitudinal monitoring reference validity varying degrees involved also mentioned potential value knowing frequency duration level variations optic nerve space pressure interaction changes potential influence lamina help determine pathological significance
randomized algorithms deep learning techniques successfully used regression classification problems however random hidden weights randomized algorithms require suitable distributions advance deep learning methods use output information system identification paper distributions hidden weights obtained restricted boltzmann machines deep learning method uses input data construct statistical features hidden weights output weights neural model trained normal randomized algorithms successfully combine unsupervised training deep learning supervised learning method randomized algorithm take advantages proposed randomized algorithms deep learning modification validated three benchmark problems elsevier inc rights reserved
aim recent years cases chronic myeloid leukemia cml reported bcr mutations moreover mutations additional sex like gene recently shown various myeloid malignancies previous studies investigating incidence mutations iranian patients cml consequently study focuses analysis mutations patients cml methods total patients clinical diagnosis cml examined time diagnosis thirty healthy subjects checked controls exon amplified genomic dna sequenced also performed screening amplification refractory mutation system polymerase chain reaction sequencing results mutations gene found five cml patients identified novel variant one patients reported also identified bcr mutations simultaneously four patients conclusion demonstration mutation putative tumor suppressor gene represents important molecular abnormality cml also showed concomitant detection bcr mutations relatively high incidence iranian patients
century old clinical reports document remarkable regenerative capacity past decade scientists undertaken mechanistic investigations regenerative potential workshop annual meeting orthopaedic research society reviewed molecular cellular tissue scale approaches elucidate mechanisms underlying regenerative potential translational therapies engineering solutions inspired remarkable regenerative capacity entire population osteoblasts within trabecular bone surfaces within bone marrow derives embryonic cells contribute cartilage bone formation within fracture healing cells bone marrow migrate marrow compartment furthermore current healing paradigm regards activation expansion differentiation stem progenitor cells essential step building template subsequent bone formation remodeling comprises complex composite structure providing niche pluripotent cells repository molecular factors modulate cell behavior advanced smart material properties change depending mechanical chemical biological state tissue understanding development progenitor cell driven initiation endogenous tissue building capacity complex relationships advanced material important harnessing engineering materials mimic remarkable regenerative capacity orthopaedic research society published wiley periodicals inc res
recently subspace fitting approach proposed vibration based finite element model updating approach makes use subspace based system identification extended observability matrix estimated vibration measurements finite element model updating performed correlating model based observability matrix estimated one using single set experimental data hence updated finite element model reflects single test case however estimates vibration measurements inherently exposed uncertainty due unknown excitation measurement noise finite data length paper covariance estimation procedure updated model parameters proposed data related covariance updated model parameters considering first order sensitivity analysis particular propagation performed iteration step updating minimization problem taking account covariance updated parameters data related quantities simulated vibration signals used demonstrate accuracy derived expressions furthermore application shown experimental data beam elsevier ltd rights reserved
introduction disseminated cancers remain fatal despite availability variety conventional novel treatments including surgery chemotherapy radiotherapy immunotherapy biologically targeted therapy major factor responsible failure chemotherapy treatment cancer development multidrug resistance overexpression various abc transporters cancer cells efficiently remove anticancer drug cell thus causing drug lose covered review ongoing research related mechanism function regulation abc transporters integrated current knowledge different levels molecular biology clinical trials also discussed potential therapeutic strategies targeting abc transporters reverse cancer opinion involvement various abc transporters cancer foundation developing tailored therapies overcome ideal reversal agent broad spectrum abc transporter inhibitory activity potent good pharmacokinetics trans stimulation effects low toxicity alternatively nanotechnology based drug delivery systems containing cytotoxic drug reversing agent represent useful approach reversing minimal target toxicity
reverse process used many industrial applications ranging solute solvent solvent solvent gaseous separation number theoretical models developed describe separation fluxes solvent solute processes paper looks scope limitations two main models irreversible thermodynamics solution diffusion models used past several researchers solute solvent feed separation despite investigation complex models simple concepts models accelerate feasibility implementation reverse different types systems variety industries briefly extensive review mathematical models conducted collecting examples literature study addition review covered improvement models make compatible multi component systems consideration concentration polarization solvent solute membrane interaction elsevier ltd rights reserved
cable important component cable supported bridges roof structures existing vibration methods cable tension estimates mainly based measured acceleration responses practice relatively expensive time consuming due required installation contact type sensors data acquisition systems study novel vision based sensor proposed accurate cost effective alternative determination cable tension forces measurement capacity vision sensor eliminates need access cable install conventional sensors highly difficult risky proposed method applied measure cable forces cable supported roof structure hard rock florida ensure cable forces reach design values series field tests carried different roof stages satisfactory observed measured cable forces vision based sensor reference readings load cells proposed method represents convenient low cost method either periodic long term monitoring cable supported structures elsevier ltd rights reserved
surfaces widely used tool computer graphics known mostly algorithms recently surface techniques started gain popularity field medical imaging mostly convenient visualization information initially represented surfaces continuous eye plot however consistently mapping information domain surface techniques allow put correspondence anatomical shapes inherently different geometry paper propose method anatomical parameterization cardiac ventricular include muscles proposed method utilizes quasi conformal myocardial surfaces left right cardiac extending cover interior using local coordinates given solution equation subsequently define geometry independent representation detailed cardiac left right ventricular used convenient visualization statistical analysis population lastly show used mapping detailed cardiac anatomy different considerable interest detailed cardiac computational models shape elsevier rights reserved
recently crimes cause internet target ones companies financial due massive crimes caused digital convergence ubiquitous system clear amount network packet need processed rising digital convergence ubiquitous system caused ids intrusion detection system process packets past version leading open source ids long history since built long time ago several limitations fit todays requirements processing unit single hand built cover disadvantages cover massive amount packets caused digital convergence ubiquitous system availability process packets multi environment paper analyzed compared processing detection rate decide better single multi environment
despite growing evidence support mindfulness underlying mechanism mindfulness based interventions suggested nonspecific therapeutic factors experience social support contribute positive effects present study examined whether change mindfulness social support mediated effect mindfulness based cancer recovery compared another active intervention supportive expressive group therapy set change mood disturbance stress symptoms quality life secondary analysis conducted multi site randomized clinical trial investigating impacts set breast cancer survivors applied causal steps approach test mediation using pre post intervention questionnaire data participants randomised set participants improved significantly mood disturbance stress symptoms social support quality life mindfulness compared set participants increased social support partially mediated impact versus set mood disturbance stress symptoms group differences mindfulness quality life observed mediation analyses performed variables findings showed increased social support related improvement mood stress compared support groups whereas changes mindfulness suggests important role social support enhancing outcomes previously thought
autism spectrum disorder asd increasingly conceptualized spectrum disorder development review evidence suggesting asd characterized positive feedback loop small functional variations early developing sensory processing pathways structural functional imbalances global neuronal using vision example discuss early functional variants visual processing feedback amplified produce variant object categories disrupted top expectations large expectation perception problems identifying individual people objects socially inappropriate generally emotional responses disrupted sensory motor coordination viewing asd terms feedback amplification small functional variants allows number recent models asd integrated genetic data
phase stability diagrams reduction mixture constructed function carbon activity oxygen pressure characteristics solution formation found stable domains including larger phases formed solid solution phases considered due greater stability use nitrogen atmosphere instead vacuum expanded stable domains solid solution phases indicating made stable conditions using stability diagrams reaction sequence reduction predicted study provide guideline preparing phases mixtures elsevier ltd rights reserved
structural aerodynamic modelling dynamic stabilization three dimensional suspension bridge model considered emphasis investigating effectiveness leading edge suppressing aeroelastic east great belt bridge chosen design example aeroelastic limits computed using thin theory flutter derivatives problem cast efficient reduced size finite element formulation aerodynamic forces expressed laplace domain use high fidelity rational function approximation aerodynamic forces modelled using feedback loop every element problem expressed form suitable implementation modern control techniques structures full multimodal response considered numerical predictions show good agreement experimental data literature order account modelling errors uncertainties designing controller elements robust control theory stability robustness bridge fitted controlled optimal suboptimal controllers discussed varying lengths control surfaces along suspended span optimum configuration aerodynamic performance investigated copyright john wiley sons ltd
objective analyze newly incurred injuries illnesses international discuss risk factors design prospective recording newly occurred injuries illnesses setting european finland participants national team local organizing committee physicians registered athletes main outcome measures incidence characteristics new injuries illnesses results ninety three percent athletes covered medical teams response rate one hundred thirty three injuries reported incidence injuries per registered athletes sixty two injuries resulted time loss sport common diagnosis strain injuries time loss injuries injury risk higher males increased age highest incidences injuries found combined events middle long distance events twenty seven illnesses reported illnesses per athlete days common diagnoses upper respiratory tract infection diarrhea conclusions outdoor injury illness incidences slightly lower injury characteristics comparable outdoor world elite gender male age older years events combined events middle long distance seem injury risk factors illness risk factors remain unclear previous recommendations preventive interventions focus overuse injuries strains adequate rehabilitation previous injuries decreasing risk infectious diseases transmission appropriate event scheduling sports heat
gender roles mainstream culture suggest girls express happiness sadness anxiety shame boys boys express anger externalizing emotions however gender roles emotion expression different low income diverse families children parents often faced greater environmental stressors different gender expectations study examined gender differences emotion expression low income adolescents understudied population one hundred seventy nine adolescents aged participated social stress test trained rated adolescents expressions happiness sadness anxiety shame anger using micro analytic coding system analyses showed consistent gender roles girls expressed higher levels happiness shame boys however contrary traditional gender roles girls showed higher levels boys also contrast cultural stereotypes differences anger boys girls findings suggest gender role inconsistent displays externalizing emotions low income adolescents acute stress reflect different emotion socialization experiences group
objectives aim study assess effect nutritional supplementation lipid based nutrient supplements corn soy blend staphylococcus aureus gut microbiota composition infants addition microbiota changes time characterized study infants methods healthy month old infants randomly assigned intervention schemes month period infants control group provided supplementary food infants groups received either corn soy blend milk protein base soy protein base months age fecal aureus gut microbiota months age analyzed quantitative real time polymerase chain reaction method results difference change bacterial prevalence counts intervention groups month study period looking total study population higher counts total bacteria genus lower counts aureus detected childrens months rather months age conclusions dietary supplementation effect aureus microbiota composition study infants fecal diversity infants however changed toward adult like microbiota profile within observed time
many different modes rolling possible causes identified years research yet clear definite theory mechanics fully established accepted two part paper stability tandem investigated part state space models single multi stand formulated rigorous comprehensive mathematical form stability rolling system investigated sense single multi stand negative damping effects first single stand model state space representation proposed coupling dynamic rolling process model structural model stand subsequently multi stand model developed incorporating inter stand tension variations time delay effect strip transportation based single stand model stability criteria proposed stability analyses performed create corresponding stability charts terms single multi stand negative damping mechanism numerical simulations particularly effect friction conditions examined explanation given existence optimum friction condition part regenerative effect resulting examined suitable stability criteria mechanism established stability charts demonstrated terms relevant rolling process parameters
athletes sports related increasingly seeking medical care management guidance return play article aims provide updated review management youth sports including planning field identification clinical management acute discussion prolonged symptoms including headache
science engineering area construction engineering works often great dimensions design life cycle many decades designed scientific basis since safety hundreds users depends design task scientific institutions define construction performance within categories correspond contemporary level knowledge technology construction way ensures competence performance elements buildings existing construction scientific basis opinions comparison construction sections basic requirements presents science construction matrix science construction reveals multi nature related time issue durability considered related scale complexity defining construction performance terms technical features constant search relationship material model usability model building construction industry uses lot rules sector technology era computer aided design cad building information modelling bim rules remain verification tools
zinc finger protein type like member family role aging related bone loss currently unknown present evidence expression rat bone marrow mesenchymal stem cells regulated aging knockdown decreased differentiation cells increased differentiation cells whereas overexpression opposite finding overexpression enhanced differentiation also corroborated vivo experiments prevented inhibiting differentiation suggesting significance ppar gamma repression inhibitory effect differentiation overexpression expression ppar gamma mrna ppar promoter activity pull electrophoretic mobility shift assays suggested interact endogenous ppar gamma mrna binding containing complexes overexpressing cells contained less ppar gamma mrna control cells luciferase reporter construct replacement poly fragment ppar gamma mrna reduced expression luciferase transcripts overexpressing cells examination kinetic expression ppar gamma mrna transcriptional showed enhance degradation transcripts together data imply overexpression least regulating ppar gamma expression post transcriptional mechanisms thus findings support notion decrease expression aging contribute aging related bone loss
combined infrastructure conventionally designed based historical climate data yet variability rainfall intensities patterns caused climate change significant impact performance urban drainage system although rainwater harvesting rwh potential solution manage stormwater urban areas benefits mitigating climate change impacts combined networks assessed yet hence goal present study set evaluate effectiveness rwh alleviating potential impacts climate change first future rainfall achieved coupled model project phase based modified historical record rainfall runoff modeling employed using epa stormwater management model study response future rainfall study site combined network city results showed maximum impact scenario near future climate change cause approximately increase occurrence volume duration however rwh plan capacity implemented half buildings throughout area appeared able mitigate potential future impacts showed remarkable controlling performance peak flow periods plan also met toilet flushing demands therefore rwh considered feasible solution mitigate future climate change impacts supply water demands elsevier ltd rights reserved
background study aimed identify important factors changing pattern drug abuse iranian women materials methods study phenomenological study data analyzed step method subjects selected patients referred addiction rehabilitation residential center welfare organization city located northeast iran results found conceptual classes codes analysis data individual factors follow elevation mood obtaining increasing energy improving performance relief physical pain sensation seeking conclusions depth review analyses interviews revealed individual factors important factor crystal abuse
objectives almost half pregnancies united states unintended pregnancies associated adverse outcomes many reproductive age females seek care emergency department risk pregnancy amenable contraceptive services setting pilot study sought assess providers current practices attitudes knowledge emergency contraception contraception non barriers respect contraception initiation methods physicians associate providers link anonymous internet questionnaire using state professional databases contacts questionnaire included likert scales multiple choice questions assess study objectives descriptive statistics generated univariate analyses using fisher exact tests results total providers questionnaires completed participants predominantly physicians men individuals younger years common practices referrals prescriptions non prescriptions common barriers perceived low likelihood follow risk complications adverse effects participants correctly identified highly effective contraceptive methods identified correct maximum initiation time correctly recognized pregnancy higher risk hormonal contraception use pulmonary embolism conclusions providers pilot study referred patients contraception however universal contraceptive counseling management many providers study incorrect understanding efficacy risks eligibility associated contraceptive methods lack understanding affect patient access barrier patient care
recent years diagnosis electric motors increasingly signal processing methods develop methods necessary reliable mathematical model physical signal processed case signal stator current unfortunately often stator current obtained expensive measurement bench complex modelling electric motor aim paper model induction motor stator current presence rotor fault diagnose model take account effects presence fault fact presence rotor fault manifested air gap oscillation load torque causes amplitude phase current purpose impact severity rotor fault two types expressed studied mathematical model also demonstrated paper work
comprehensive psychiatric rehabilitation programs latin america designed across several countries region without yet achieving full implementation facing increasing burden disease due mental disorders including alcohol substance use disorders region responded challenge moreover low priority mental health national policies insufficient funding mental health services common barriers much needed mental health services reforms primary care community based model care shared aspiration countries last two decades comprehensive models psychiatric rehabilitation developed predominantly high income countries need culturally adapted local contexts strengthening health systems research provide evidence efficiency locally designed interventions critical succeed scaling strategies increasing participation patients families mental health delivery system another key factor order ensure comprehensive patient centred psychosocial rehabilitation programs latin america
suicide major cause death throughout world recent studies proved reliable connection emotional traits suicide however detection prevention suicide mostly carried clinical centers limit effective treatments restricted group people assist detecting suicide risks among public propose novel method exploring accumulated emotional information peoples daily examining emotional traits predictive suicidal behaviors complex emotion topic model employed detect underlying emotions emotion related topics streams based eight basic emotion categories five levels emotion intensities since suicide caused process propose three emotional traits accumulation covariance transition consecutive emotions employ generalized linear regression algorithm examine relationship emotional traits suicide risk experiment results suggest emotion transition trait turns discriminative suicide risk combination three traits linear regression generate even discriminative predictions classification suicide articles additional experiment verifies result finally conduct case study commonly mentioned emotion related topics suicidal understand association emotions thoughts authors
study proposes model predictive control mpc light rail vehicles using maximum current constraint study kalman filter used estimate system states compared pid controller mpc based charging control strategy solve maximum current limit problem converts charging problem optimization one simulation experiments carried demonstrate effectiveness method
organic rich systems play important role worlds volatile petroleum industry due complex pore structures large portion nano pores flow mechanics gas flow pore space involve nanoscale effects accounted classic law also difficult experimentally probe transport properties extremely low permeability rock samples digital rock physics obtains direct view internal structure reservoir rock sample high resolution images compute properties porosity directional permeability hence enable studies multi scale flow mechanics study present parallel lattice boltzmann method studying nanoscale effects three dimensional tube flow simulate flow process gas flow real pore geometry two samples combining image processing methods pore geometry obtained digital image data based ultra high resolution ray computed tomography imaging numerical advantages lattice boltzmann method make powerful tool simulate gas flow nano pores estimate absolute permeability new parallel implementation successfully performed powerful high performance computing cluster validated analytical solution tube flow model taken elementary model pore networks simulating nanoscale effects roughness gas flow nano tube model propose realistic parameters simulating gas flow real study flow mechanics calculate apparent directional permeability results show simulated close measured estimated apparent permeability close measured permeability apparent directional permeability able estimated identified pores connected direction image resolution voxel permeability anisotropy clearly observed velocity field visualization calculated permeability values characteristics pore geometry flow velocity distribution transport properties captured using effective way simulate complex gas flow pores estimate apparent directional permeability elsevier rights reserved
humans help attribute human emotions non human animals although attributions often regarded held apart attributions humans make others internal states product general mechanism flexibly interpreting adaptive behavior examine used functional magnetic resonance imaging fmri humans compare neural mechanisms associated emotions humans non human animal behavior although undergoing fmri participants first observed facial displays human non human domestic dogs subsequently judged acceptability emotional facial descriptions teeth images targets emotion attributions selectively activated regions prefrontal anterior temporal cortices associated causal explanation prior studies regions similarly activated human non human targets even passive observation task moreover degree neural similarity dependent participants self reported beliefs mental capacities non human animals results encourage non view emotion understanding one idea animals emotions idea humans
network security quality service qos consume computational resource system thus affect application services case limited computational resource important model mutual influence network security qos concurrently optimized order provide better performance available computational resource paper evaluation model accordingly presented describe mutual influence network security qos multi objective genetic algorithm revised optimize multi objective model using intrinsic information target problem new crossover approach designed enhance optimization performance simulation results validate algorithm find set pareto optimal security policies different network workloads provided potential users differentiated security preferences obtained pareto optimal security policies meet security requirement user also provide optimal qos available computational resource elsevier ltd rights reserved
nucleus amygdala critical pathophysiology anxiety driven alcohol drinking relapse endogenous type receptor system driven anxiety stress responses via negative feedback system inhibits neurotransmitter release activation reduces gaba release drives additionally decreased amygdala observed alcoholic patients ethanol rats investigated potential disruption signaling transmission neurons rats exposed intermittent ethanol naive rat agonist decreased gaba release effect prevented antagonist alone increased gaba release via mechanism requiring calcium dependent activity signaling diminished chronic ethanol exposed rats suggesting functional impairment system contrast acute ethanol increased transmission similarly naive chronic ethanol exposed rats via mechanisms notably activation impaired facilitation transmission across groups induced ethanol induced facilitation gaba release additive suggesting independent sites action collectively present findings highlight critical influence transmission dysregulated chronic ethanol exposure thus contribute alcohol dependent state
vertex non loops processed form combinations loops graph similarly graph based method needs spanning loop sets required obtain transfer function solve equations system represented signal flow graph boolean formula presented note obtain boolean function formed comprising product pairs loops connected component simplified using rules boolean algebra resulting terms complemented derive combinations non loops graph using additional boolean rule formula gives spanning loop sets graph graph need connected
conversation health messages campaigns common message related conversations increasingly recognized factor shaping message effects evidence base limited however conditions conversation help hinder health communication efforts study college students first watched short sleep video randomly assigned either talk partner online conversation proceed directly short survey unknown participants partner say positive things sleep message positive condition negative things negative condition unrelated things natural condition respondents completed short survey beliefs sleep reactions message intentions get adequate sleep respondents greater intentions engage healthy sleep engaged positive conversation following message exposure engaged negative conversation message positive emotion experienced response message positive perceptions significant predictors intentions achieve healthy sleep health message designers benefit understanding messages peer peer conversation better predict explain effects
background analyses subcortical gray structure volumes non idiopathic parkinsons disease often always show volume loss putamen nucleus nucleus hippocampus building evidence structure morphometry sensitive disease related processes volume objective assess morphometric differences subcortical structures putamen nucleus thalamus nucleus amygdala hippocampus non individuals relative age education matched non peers methods prospective recruitment idiopathic dementia non peers part funded investigation weighted metrics acquired via individuals left side onset right side onset non first software library applications provided volumetric vertex analyses group differences structure size morphometry results group volume differences observed putamen non hippocampal volume significantly disease duration group shape differences observed bilateral putamen nucleus hippocampus greater striatal atrophy contralateral side motor symptom onset hippocampal shape differences disappeared removing effects volume conclusion putamen primary structure show volume shape differences indicating putamen predominant site basal ganglia atrophy early mid stage side symptom onset associates contralateral striatal atrophy left onset experience extensive striatal atrophy right onset hippocampus morphometric results suggest possible primary atrophy gyrus
traditionally testosterone estrogen considered male female sex hormones respectively however estradiol predominant form estrogen also plays critical role male sexual function estradiol men essential modulating erectile function estrogen receptors enzyme converts testosterone estrogen abundant brain testis organs important sexual function brain estradiol synthesis increased areas related sexual arousal addition estrogen receptors found throughout corpus high concentration around low testosterone elevated estrogen increase incidence erectile dysfunction independently one another testes modulated every level estrogen starting hypothalamus pituitary gonadal axis followed germ cells epithelium mature sperm regulation testicular cells estradiol shows inhibitory influence indicating intricate dose dependent temporally sensitive modulation goal review elucidate overall contribution estradiol male sexual function looking hormones effects erectile function
high performance magnetic resonance imaging systems gradient driver required supply gradient coil large current high voltage achieve strong gradient field fast slew rate addition extremely high fidelity reproducing current command central system critical imaging quality paper presents solutions different elements driver high bandwidth power inverter ripple filter power supply digital control high power inverter requires stacked bridges structure achieve high output ripple frequency existing commercial power semiconductor modules high voltage high frequency large power modules obtained easier lower loss using new silicon devices control needs digital implementation fast processor digital control provides compensation feedforward improve response capability improvement obtained reducing switching frequency large currents low frequency variation needed control handle filter designed eliminate one ripple frequency finally many solutions used multiple isolated outputs digital control compensation permits use much simpler keeps performance platform built fully tested experimental results proved validity proposed structure modulation technique
two strains nitrogen native indian fields displayed differential sensitivity exposure neutral strain strain displayed reduction survival dose following exposure respectively responsive proteome alterations visualized gel electrophoresis followed protein identification maldi tof mass spectrometry two strains displayed significant differences levels proteins associated photosynthesis carbon metabolism oxidative stress tolerance higher tolerance strain attributed sustained photosynthesis carbon metabolism superior oxidative stress defense compared sensitive strain significance responsive proteome two nitrogen strains native indian fields revealed rapid adaptation better oxidative stress management maintenance metabolic energy homeostasis underlies superior tolerance strain compared strain elsevier rights reserved
objective unintended pregnancy important public health problem world due negative effects mother child health common causes unintended pregnancies misuse contraceptive methods aim study determine recognition frequency emergency contraceptive methods among women related factors situation material method descriptive study conducted research education hospitals outpatient clinics women aged years attend clinics due health problem enrolled study data collected questionnaire generated investigators values considered significant results fifty five point five percent women enrolled study using modern contraceptive methods faced unintended pregnancy least one time sexual life unintended pregnancies resulted rate unintended pregnancy higher women higher pregnancy count forty eight point nine percent participants thought impossible prevent pregnancy unprotected sexual intercourse rate women aware least one expressions emergency contraception forty five women known exact meaning emergency contraception emergency contraception usage rate general population women aware emergency contraception conclusion possible decrease unintended pregnancies using emergency contraception properly however knowledge women emergency contraception inadequate therefore education programmes conducted
paper focuses variability vibration electromagnetic origin electric motor modeling introduced magnetic force density computation coupling electromagnetic structural dynamic finite element models modal stability procedure monte carlo simulation associated variability calculation natural frequencies frequency response functions finite element systems material random parameters formulations developed node solid element modeling electric stator approach requires single finite element analysis leading fast monte carlo simulation using formulation validation investigated uncertainty propagation discussed computational costs presented non intrusive method provides evaluation frequencies variability industrial size models large number degrees freedom large number random variables low moderate variability level elsevier rights reserved
background study aimed identify resilience burnout status nurses working field oncology methods descriptive study conducted oncology nurses data collected using sociodemographic attributes form resilience scale adults burnout inventory percentage ratios mean median values test mann whitney test correlation analysis multiple stepwise linear regression analysis used evaluate data results burnout inventory total median score emotional median score median score personal median score resilience scale adults total median score median resilience subscale scores structural style perception future family cohesion self perception social competence social resources respectively relationship existed emotional perception future structured style self perception personal structured style perception future self perception multiple stepwise linear regression analysis revealed significant relationship number years field emotional scores moreover significant relationship structured style variables personal scores observed conclusions study demonstrated relationship burnout resilience situations among oncology nurses results used plan individual organizational interventions increase resilience reduce experience burnout developing measures improving communication skills providing education stress management coping strategies using social resources organizing programs provide psychological support
number second generation non used clinical practices world however long term safety efficacy proved high level evidence based medicine performed open label multicenter phase iii study evaluate long term safety efficacy novel non patients chronic spontaneous urticaria pruritus associated skin diseases trial registration patients aged years treated daily weeks safety tolerability assessed basis adverse events related laboratory tests vital signs efficacy assessed based rash score score overall improvement quality life one hundred ninety eight patients enrolled completed week treatment period reported related patients throughout week treatment period mild moderate severity associated nervous system occurred patients including seven patients headache reported two patients related efficacy variables improved treatment conclusion long term treatment daily weeks safe tolerated japanese patients pruritus associated skin diseases improved disease symptoms conditions early treatment efficacy maintained throughout treatment
background knockdown resistance caused alterations voltage gated sodium channel one mechanisms responsible resistance asian least four different mutations described segment populations asia north america europe contrast least non mutations reported nine different mostly segments mutation segment prevalent populations worldwide also found singapore herein investigated dna diversity corresponding segments natural populations brazil methods dna eight brazilian natural populations individually extracted pooled states origin amplified cloned sequenced corresponding segments additionally samples location individually genotyped allelic specific pcr pcr approach obtain genotypic allelic frequencies site results non substitutions observed sequences however mutation evidenced segment sequences states state allele varied knowledge paper reports first occurrence provides distribution data possible mutation south america conclusion emergence likely mutation natural populations signal alert vector control measures since popular adopted residents additionally allele present frequency tends increase faster compounds although asian important vector viruses south america importance regard extensively discussed since rapidly spreading also migrate urban environments therefore resistance monitoring initiatives also extended brazil order maintain chemical compounds efficient vector control tool needed
tau forming considered crucial event pathogenesis alzheimers disease mir belongs microrna mirna family markedly decreased however functions mir pathogenesis remain unknown observed expression mir significantly decreased cells transfection mir mimics attenuated cell apoptosis abnormal tau protein without changes total tau protein also increased expression levels kinase akt akt akt glycogen synthase kinase beta beta beta cells found mir directly targeted mir inhibited abnormal tau regulating akt beta pathway study reveals mir play neuroprotective role provide new ideas therapeutic targets
study design retrospective cohort objective purpose present study examine incidence risk factors postoperative requiring patients undergoing single level lumbar fusion surgery summary background data postoperative cause devastating neurological consequences spine surgery risk factors specific spine procedures established methods cohort patients undergoing single level lumbar fusion surgery constructed american college surgeons national surgical quality improvement program dataset using current procedural terminology codes cases requiring within days initial surgery postoperative identified using icd code risk factors postoperative assessed logistic regression modeling results patients undergoing single level lumbar fusion surgery patients developed postoperative requiring heightened incidence postoperative found patients smokers diagnosis bleeding disorder without bleeding disorder multivariate logistic regression analysis indicated adjusted odds ratios postoperative associated smoking bleeding disorder confidence interval confidence interval respectively conclusion smoking bleeding disorder appear major risk factors postoperative requiring single level lumbar fusion surgery intervention programs targeting patients risk factors needed reduce excess risk postoperative
anterior cingulate cortex acc commonly associated cognitive control decision making specific function highly debated explore recent theory acc reward values task contexts psychological review trends cognitive sciences recorded event related brain potentials participants played novel gambling task participants first required select among three games one virtual subsequently required select among three different games different virtual games higher one analysis reward positivity erp component believed reflect reward related signals carried acc dopamine system revealed acc sensitive differences reward values associated games inside indicating participants learned values contexts rewards delivered results highlight importance acc learning reward values task contexts order guide action selection
nowadays many proposals allow users perform fuzzy queries relational databases regardless proposals fuzzy queries really useful scalar values fuzzy sets adjusted user needs domains non scalar values complex task extend non scalar attribute management fuzzy queries use ontologies thus allow compute kind queries similarity relationships defined explicitly fuzzy set semantically interrelated terms modeled domain ontology moreover present architecture novel system combines techniques return answer much complete possible ordered degree finally qualitative quantitative study use flexible queries relational databases included work elsevier inc rights reserved
paper static dynamic stiffness rubber subjected compression shear investigated rubber bearing applications static stiffness existing models describe rubber behaviors based linear elasticity assumptions adequate excessive deformation first part paper modeling materials utilizing finite element analyses key assumptions classic formula first examined rubber behaviors compression shear simulated found classic formula stiffness rubber particular rubber high shape factors compression shear stiffness ratio considerably classic relation typical working strain levels significantly affect machine performance prediction design hand due viscoelastic nature dynamic stiffness rubber bearings varies working frequencies affecting precision control second part work rubber modeled three parameter general maxwell fluids dynamic stiffness evaluation combining original rubber bearing additional elastic even secondary rubber possible change original rubber stiffness compression shear directions finally designs reduce high frequency shear stiffness enhance steady state compression stiffness rubber bearings proposed demonstrated
domestic rainwater harvesting widely recognized alternative source water taiwan water suggests rainwater potential maximized quantified article assess potential national level consider climatic building characteristic economic ecological aspects propose three categories theoretical available environmental rainwater potential four main steps followed develop proposed framework fifteen rainfall zones across taiwan generated cluster analysis based average annual day rainfall distributions rainfall stations administrative districts roof area rainfall zone estimated using geographic information system gis land use classification database weighted percentage rainwater use rainfall zone determined optimal point storage capacity rainwater supply reliability curve equivalent building building type percentage total roof area used harvest rainwater region depends downstream impact stream flow procedures developed study constitute effective tool estimation national potential
study design eleven patients painful osteoporotic vertebral fractures underwent using calcium phosphate cap cement followed week years retrospective trial objective study investigates long term features cap cement implants cap cement years implantation summary background data frequently used treatment painful osteoporotic fractures materials available cap frequently used filling material resorption material frequently observed although clinical outcome comparable methods utilizing cap cement performed patients painful osteoporotic vertebral fractures patients received pharmacological treatment consisting calcium vitamin standard dose oral measurements pain mobility assessed results cap cement volumes decreased significantly years however vertebral stability determined constant vertebral body height sagittal index impaired pain improved significantly years implantation mobility scores year least third year conclusions cap cement implants slowly time without stability clinical outcomes likely slowly progressing replacement cap cement material procedure almost completely early years leakage occurred therefore cap cement important alternative based cement materials utilized osteoporotic vertebral fractures
field network security researchers implemented different models secure network intrusion detection system also one open source tool intrusion detection prevention system today intrusion detection system growing technology network security mostly researchers focused field used signature rule based technique anomaly based techniques improve security network paper propose rule base intrusion detection system self generated new efficient port scan detection rules rules used detect naive port scan attacks real time network using basic analysis security engine base base used view results end web page graphic user interface rule based intrusion detection system match signature efficient port scan detection rules captured packet definition signature based ids new based ids useful reduce false positive alarm
escherichia coli able utilize sole carbon source genes transport initial step metabolism form single forms abc type high affinity transporter involved conversion phosphate absence inducer type transcription factor encoded gene located downstream present believed target regulation genomic screening however identified binds promoter also promoters set genes involved nucleotide metabolism northern blotting analysis indicated novo synthesis nucleotide activates add genes involved pathway nucleotide synthesis taken together propose global regulator switch control novo synthesis nucleotides pathway
first part paper describes mechanical structure small sized modular robot second part reserved determination geometric model robot using method rotation matrices third part presents kinematic model determined using iterative method kinematic modeling equations geometric kinematic models determined help first three modules generalized modeling application robot symbolic useful simulation geometric kinematic behavior analyzed robot
introduction allergy results aberrant type inflammatory response triggered wide range environmental antigens allergens lead various immune responses production immunoglobulin ige two key cytokines interleukin critical induction type response implicated multiple atopic covered review summarizes recent developments elucidated components pathogenesis atopic diseases atopic dermatitis asthma chronic nasal expert commentary several therapeutic agents selectively target type pathway shown efficacy one atopic diseases agents proven broadly applicable across three atopic diseases human monoclonal antibody simultaneously inhibits signaling demonstrated significant clinical efficacy asthma fact diseases often occur comorbidities respond therapy suggests common underlying pathogenic pathway cytokines central regulating pathogenesis atopic diseases
interest identifying specific brain regions related individual differences true false memories previous functional neuroimaging studies showed activities hippocampus right gyrus gyrus associated true false memories study thus far examined whether structures brain regions associated short term long term true false memories address question current study analyzed data healthy young adults valid data structural brain imaging misinformation task misinformation task subjects saw crime scenarios received misinformation took memory tests crimes hour later years results showed bilateral hippocampal volume associated short term true false memories whereas right gyrus volume surface area associated long term true false memories study provides first evidence structural neural bases individual differences short term long term true false memories
axial flux machines featured compact size high performance suitable electric vehicles paper studies design control totally axial flux integrated generator system torque density volume benefits large number pole pairs designing machines however increased pole pair number decreases switching frequency electrical period ratio large power drives limited switching frequency improve situation control strategy named technique variable sampling frequency proposed improve system performance nonlinear region heat dissipation potential inverter fully utilized bus voltage utilization ratio enhanced control strategy simulation results carried current waveform also improved
synthesis procedure general order voltage transfer functions using solely voltage differencing buffered amplifiers capacitors signal flow graph design method described shown proposed structure employs capacitors realization order voltage transfer function illustrative example third order voltage mode filter designed simulated using pspice
study periodic solutions suspension bridge model proposed periodic damping term type condition small periodic damping term condition existence uniqueness periodic solution proved constructive method two numerical examples presented illustrate effect periodic damping term
using data collected canada united states united kingdom article examines determinants attitudes toward immigrants particular draw literature social psychology explore role locus control promoting restrictive attitudes towards immigration control three levels perceptions individual locus control feeling one control ones circumstances perceptions societal control feeling ones country control immigration perceptions locus control feeling social circumstances attributable rather external factors results show three measures control important predictors negative attitudes toward immigrants feel control society less hostile towards immigrants attribute negative outcomes immigrants also hostile results also suggest measures control related distinct racial prejudice
purpose paper aims contribute highlighting salience feminine caring positions creating novel roles investigating roles contribute community resilience using critical feminist economics lens alternative economy expanded upon reveal economic influences discourse gender roles community resilience design methodology approach approach empirical evidence drawn six months intensive ethnographic research tourism micro greece hence context crisis ethnographic interviewing participant observation used methods achieve research objectives findings thematic analysis used investigate gender roles roles interact interaction influences community resilience economic crisis using critical theory economics interpretations becomes evident economic structures responsibility social reproduction feminine roles roles positive effect increasing community resilience involvement primarily community gain participants highlight feminine discourse differs economics discourse involvement primarily individual gain social implications paper contributes theoretical advancements role gender community resilience investigating gendered responses exogenous shock providing insight role gender adaptation sustainable business practices means new policies combat social exclusion promote rural development formulated originality value theoretical interplay gender investigated novel angle critical feminist economics relationship interpretations community resilience brought light providing unique insight resilience
fracture clinical manifestation osteoporosis one main causes functional limitations chronic pain patients osteoporosis muscle coordination training recommended patients general measures whether training better traditional physiotherapy pain improving abilities daily living fifty patients osteoporosis divided two groups group performed conventional physiotherapy group performed training exercises data collected intervention months registered parameters posture pain posture torques associated strength spinal muscles studied biomechanical model order estimate forces acting spine furthermore factors exerted positive impact success therapy registered forty four patients completed study positive effects training noted groups significantly better effects observed group performed training reduction pain independent number fractures significantly reduced torques reduced muscle strength registered specific training programs helped increase muscle strength back thereby reducing force needed permanent basis decreasing torque spine training effective traditional physiotherapy
mining activities among major wide occurrences soil water pollution coal district resulted ecological health risk local residents sixteen multimedia environment coal district south china measured aiming investigate contamination level distribution possible sources estimate potential health risks average concentrations coal coal soil surface water groundwater respectively additionally higher soil water concentrations detected coal coal composition analysis ratio pearson correlation analysis principal component analysis performed diagnose potential sources different environmental matrices suggesting dominant inputs coal coal combustion coal soil water soil water guidelines incremental lifetime risk used assess health risk showing soil water heavily contaminated mean coal mean significantly higher acceptable levels high potential carcinogenic risk residents especially coal workers study highlights environmental pollution problems public health concerns coal mining particularly potential occupational health hazards coal exposed
designed solve issue adopting addresses presenting large number address spaces currently many networking devices consider supportive enabled device includes personal computers mobile phones security increasingly become significant issue exploiting networks obtaining benefits one important protocols implementation used neighbor discovery however protocol used attackers network services flooding attacks decrease network performance solve problem study proposes intelligent flooding attack detection framework using back propagation neural network networks study also explores analyzes detection accuracy proposed framework effectiveness framework demonstrated using real data sets obtained laboratory data set traffic based test bed environment created basis certain parameters used inputs generate new data set results prove proposed framework capable detecting flood attacks detection accuracy rate
different types serious games used elucidating computer science areas computer games mobile games based games virtual worlds web based games different evaluation techniques conducted like questionnaires interviews discussions tests simulation widely used computer science motivational interactive learning tool paper aims evaluate possibility successful implementation simulation computer programming modules framework proposed measure impact serious games enhancing students understanding key computer science concepts experiments held university students test framework attain results
degradation urban river ecosystems presents serious threat sustainable urban development consequently extensive efforts devoted ecological restoration urban rivers worldwide study evaluates environmental associated water pollution river restoration southern china basic pricing model applied test hypotheses using sample transaction records july december results show river restoration reverse negative polluted positive especially located floor lower water quality improvement polluted non recreational water grade worse non body contact recreational water grade increase values river restoration including river bank water quality improvement increase property values demonstrating preference residents study provide scientific basis urban river governance communities decision makers serve reference case elucidate human preferences river restoration rapidly developing countries elsevier rights reserved
purpose clarify mechanism mediating effect hyperthyroidism cardiac function second month life rats methods male female sprague dawley rats assigned control triiodothyronine treated group treatment group started third day birth control rats received nacl body weight every second day days treated rats hyper received subcutaneous injections every second day days results hyperthyroidism decreased left ventricle volume male rats female euthyroid rats presented higher atrial nitric oxide synthase activity male rats hormonal treatment decreased enzymes activity sexes euthyroid male female rats similar atrial protein levels females higher protein levels treatment increased protein males female rats lower ventricular activity male rats hyperthyroidism increased activity sexes effect associated lower protein levels hyperthyroidism change protein levels male female rats conclusions results study demonstrating clinically relevant sex related differences pathophysiology heart raised new questions regarding mechanisms responsible observed differences study suggests sex related intrinsic factors nitric oxide modulate response hyperthyroidism leads cardiovascular dysfunction
resource efficient europe aims waste managed resource thus materials ability reuse several types wastes activated cement based merit special attention wastes like fly ash deserve special attention generated high amounts low reuse rate paper reports experimental results regarding influence mix design fly ash waste glass containing two different short term mechanical performance microstructure cost analysis also included results show mixture fly ash waste glass calcium activated alkaline activator highest compressive strength results also show minor content associated relevant increase compressive strength use leads optimum compressive strength mixtures use shows beneficial effects compressive strength several mixtures even show reduction compressive strength
genotype hepatitis virus hcv prevalent variants virus subtypes hcv hcv associated differences epidemic features risk groups despite sharing similar features biological properties analyzed impact positive selection evolution variants using complete genome coding regions compared levels genetic variability distribution positively selected sites also compared distributions positively selected conserved sites considering different factors rna secondary structure presence different epitopes antibody secondary protein structure genome found positive selection selection main evolutionary process acting subtypes found differences number positively selected sites subtypes several genes core values positively selected sites rate non substitutions significantly higher logistic regression analyses revealed similar selective forces act genome level subtypes rna secondary structure cell epitopes conserved sites cell epitopes positive selection subtypes results indicate similar selective constraints acting along hcv hcv genomes despite differences distribution positively selected sites independent genes elsevier rights reserved
rising temperatures begun shift time unclear whether phenotypic plasticity accommodate projected temperature change century evaluating traits extent variation plasticity provide key information assessing risk developing strategies mitigate climate change study flower examined populations big growing three common date varied days late july late november among mixed effects modeling explained variation date assigned plasticity genetic variation plasticity genetics conditional marginal two environmental variables explained genetic variation photoperiod onset spring date accumulating degree days degrees reaching genetic variation mapped contemporary future climates decades showing flower date change varies considerably across landscape plasticity estimated accommodate average day change date however examination genetic variation plasticity suggests magnitude plasticity affected variation sensitivity photoperiod temperature common lower latitude populations greater plasticity days compared higher latitude populations days mapped date contemporary future climates illustrate wide breadth plasticity large geographic overlap research highlights importance integrating information genetic variation phenotypic plasticity climatic niche modeling evaluate plant responses elucidate vulnerabilities climate change
immunization programs around world undergo rapid change expansion supply chain systems become making increasingly challenging national public health systems provide reliable safe efficient access vaccines governments immunization partners aware problem several years world health organization launched effective vaccine management process help countries identify shortcomings immunization supply chains develop plans systematic improvement improvement plans now exist eligible countries plus many middle upper income countries however implementation slow many cases financial managerial structural political recognizing significant change kind requires supportive policy environment strong leadership path began working landscape policy environment around immunization identify relevant policies administrative technical roles responsibilities issues affecting supply chain immunization policy landscape assessments included review series structured depth interviews key international national local stakeholders findings highlighted number critical issues challenges countries preventing supply chains functioning optimally challenges include need better coordination planning immunization programs supply chain managers need sufficient timely reliable aspects immunization programs need high level managers trained immunization supply chain management urgent need better timely data decision making overcoming challenges require involvement high level political actors including health officials ability influence policy personnel structural changes ensure work plans adequate resources implementation hold program managers achieving agreed indicators authors published elsevier ltd
importance body sensor networks monitor patients prolonged period time increased advance home healthcare applications sensor nodes need operate low power consumption constraint limited memory capacity therefore sensor signal constant sample rate given frequency contents signals vary time adaptive sampling established practical method reduce sample data volume paper low power analog system proposed converter clock rate perform peak algorithm second derivative input signal presented implementation require analog digital converter digital processor sample selection process criteria selecting suitable detection threshold discussed maximum sampling error limited circuit level implementation presented measured results exhibit significant reduction average sample frequency data rate respectively
power loss due mismatch effect among interconnected photovoltaic modules significantly reduced applying maximum power point tracking fine granularity level paper novel configuration proposed utilize sub module integrated converter effective solar energy harvesting field effect transistors used construct power circuits high conversion efficiency high power density detailed mathematical analysis presented provide insight architecture simulation carried demonstrate system behavior response real world atmospheric conditions hardware prototype consisting three developed utilizing power switches based industrial standard compact fit junction box commercial modules advantages terms conversion efficiency system cost dynamic performance experimentally proved comparison benchmark system
multilevel inverters nowadays widely used high power high voltage applications multilevel inverter large number levels get desired output voltage levels lot merits improved output waveform smaller passive filter size lower electro magnetic interference reduced harmonics however multilevel inverters also disadvantages increased number components voltage balancing problem higher switching losses paper presents pid controlled cascaded bridge eleven level inverter based sinusoidal pulse width modulation control technique suitable improved power quality applications main objective reducing thd output chosen eleven level cascaded inverter set point tracking steady state fast transient response proposed control point view simulation results discussed cascaded bridge eleven level inverter performs perfectly connection pid comparative analysis two different controllers revealed harmonic spectrum output voltage current waveforms obtained validate role controllers experimental results presented confirm simulation results
previous assessments childhood indicated maternal birth characteristics associated tumor development however much work remains identify novel confirm suspected risk factors objective evaluate associations maternal birth characteristics childhood case control study included cases pair matched controls cases enrolled trial run intergroup study group population based controls identified using random digit individually matched cases race sex age families case control subjects participated telephone interview captured information maternal characteristics birth control use number prenatal visits anemia abnormal bleeding pregnancy birth characteristics birth weight preterm birth type delivery vaginal conditional logistic regression models used calculate odds ratio confidence interval exposure adjusted age race sex household income parental education two common histologic types alveolar evaluated effect heterogeneity exposures characteristic associated childhood statistically significant abnormal vaginal bleeding pregnancy birth control use anemia pregnancy preterm birth positively associated childhood statistically significant low birth weight adjusted odds ratios aor high birth weight aor strongly associated alveolar however factors display significant effect heterogeneity histologic types characteristics overall found little evidence maternal birth characteristics strongly associated childhood
purpose purpose paper investigate impact control strategy selection power performance wave energy converters different ratings power take system design methodology approach case point absorber equipped electric considered effect control techniques electrical generator design analyzed theoretical verified integrated hydrodynamic electric simulations findings proved control parameters maximize power extraction waves derived based power torque constraints imposed electrical machine originality value optimized integrated approach control strategy selection generator design point presented maximizes electric power generation sea waves real conditions represents good trade technical economic
experimental study focuses unsteady pressure characteristics two box bridge models vertical plates several gap length configurations investigated compared single box cross sections results demonstrate respect unsteady pressure characteristics upstream box affected slot behaves similarly single box model contrast unsteady pressure characteristics box defined mainly characteristics slot geometry cross section upstream box geometric configuration plays minor role definition unsteady pressure characteristics box equivalent function used calculation aerodynamic derivatives two box proposed using function demonstrated aerodynamic derivative dependent gap length findings suggest results single box investigations extended two box cross sections elsevier ltd rights reserved
context data incidence injury middle school sports limited objective describe overall practice game injury rate patterns middle school sports design descriptive epidemiology study setting injury data collected year period single school patients participants boy girl athletes participating middle school sports respectively main outcome measure injury status athlete exposures aes collected certified athletic incidence rates per aes injuries aes calculated overall incidence practices games injury location injury type injury severity time lost participation rate ratios confidence intervals cis used compare injury rates sex matched sports results football highest injury rate injuries aes time loss injuries aes matched middle school sports girls exhibited higher injury rate injuries aes time loss injuries aes boys injuries aes time loss injuries aes girls higher injury rate practices aes games aes sports higher game injury rate girls practice game injury rates nearly identical boys sports football boys reported higher game injury rates injuries accounted middle school injuries conclusions risk sport related injury middle school level greater practices games greater girls boys sex matched sports conditioning programs needed address high rate injuries
many atypical antipsychotic drugs currently prescribed treatment schizophrenia limited brain penetration due efflux activity atp binding cassette abc transporters blood brain barrier including herein describe design synthesis first class dual inhibitors inhibitors based structure atypical antipsychotic drug transport substrate transporters synthesized characterized small library inhibitors contain variety joining two monomers via ester linkages majority compounds low sub inhibitors cells overexpressing transporters human cells derived potent dual inhibitor also contained internal disulfide bond allowed rapid monomer presence reducing agents plasma increase stability engineered contain two methyl groups alpha carbonyl ester moiety within resulting also potent dual inhibitor remained susceptible reducing conditions resistant breakdown human plasma importantly accumulated subsequently therapeutic monomer reducing environment cells thus molecules serve two purposes acting bath inhibitors effectively delivering therapies brain otherwise
players monitor others gaze throughout providing form implicit nonverbal communication player infer intention potential strategies estimating gaze another especially located early work progress paper details exploratory study design explores effects gaze awareness particular gaze one players augmented game revealed others believe players change strategies gaze becomes common knowledge also used form explore effects game two settings screen based digital version players separate rooms located board game version augmented work evaluates effects gaze awareness settings providing new insights towards emerging research
generalized anxiety disorder common mental disorder several treatment options including patients respond treatment quickly determining patients respond important treatment goal patient level data pooled nine phase iii randomized double blind short term placebo controlled trials treatment efficacy outcomes included change baseline hamilton anxiety scale total score somatic subscales predictive modelling assessed baseline characteristics early clinical responses determine predictive clinical improvement endpoint total patients included analysis placebo significantly improved total score compared placebo endpoint treatment difference confidence interval significantly improved somatic scores compared placebo improvement total somatic score predictive endpoint greater equal improvement total score effective treatment option patients patients early response likely respond significantly endpoint copyright wolters kluwer health inc rights reserved
data analogue signals detectors digital data essential process ion beam analysis low cost easy availability development environments low learning threshold makes system chip soc attractive task combine one die analogue digital inputs outputs serial interfaces opens simple implementation tailor made interfaces specific measurement systems investigated design performance limitations based development three different interfaces two channel nuclear instrumentation module adc event mode interface high resolution magnetic spectrometer simple multi channel combined dual channel shown soc based interfaces analogue spectroscopy pulses systems implemented material costs less epsilon performance soc devices many applications close achieved state art instruments simple pulse spectroscopy interface circuit software included auxiliary elsevier rights reserved
major pest species commercial production throughout world demand alternative control measures following recent withdrawal number chemical control options led label extension use fungal control semi field trials conducted evaluate efficacy two alternative formulations strain active ingredient control effect crop yield incorporated data collected two replicated trials demonstrated incorporation detrimental yield also ineffective controlling development larvae artificially subsequent laboratory demonstrated eggs larvae susceptible infection strain whereas somewhat susceptible mortality conducted adult using exposure surface resulted mortality within days mean survival time days significantly different control population elsevier inc rights reserved
closed loop systems electro hydraulic servo system including position acceleration force closed loop systems closed loop transfer functions based parameter model adaptive identified using recursive extended least squares algorithm position force closed loop tracking controllers designed proportional integral derivative controller tuned position force step signals acceleration closed loop tracking controller designed three variable controller three states include position velocity acceleration experimental results estimated position acceleration force closed loop transfer functions performed actual electro hydraulic servo system using rapid prototyping technology clearly demonstrate benefit adaptive identification method
aiming emulsion impact cone type piston buffering structure adopted minimize process simulation model differential connection piston built software influences different buffer length angles buffer clearance terminal velocity pressure analyzed according model optimum parameters half cone angle degrees length determined collision progress piston guide software shows maximum stress edge liquid inlet hole guide maximum stress interface less area lower strength materials guide shock resistance however found phenomenon buffering process prevented
paper presents comparative analysis different stakeholders view leed certified building projects indoor quality parameters perspective key performance indicators satisfaction project cost performance within context comprehensive literature review studies indoor environmental quality relationship satisfaction terms thermal comfort acoustic control project cost investment performances etc conducted analytical hierarchy process ahp model constructed indicating effects parameters satisfaction project cost performance ratings effects parameters collected workshop participation different sustainable design researchers practitioners leed data analysed conducting ahp analysis multi decision method analysis results thermal comfort interior lighting daylight acoustic performance environmental tobacco smoke control parameters highest among satisfaction whereas low emitting materials daylight thermal comfort acoustic performance ones project cost performance
paper first describe low energy nuclear theory apply describe smart material piezoelectric rock induce nuclear reactions production observed experimental program set realizing also briefly noted
lead quantum dots emerged promising new platform lighting applications however date light emitting diodes led based materials exhibit limited efficiencies one hypothesized limiting factor fast recombination using spectroscopic techniques investigate interaction recombination mechanisms lead mapping dependence lifetime binding energy size composition find strong interactions among results weakly accounts low light emission efficiencies observe strong confinement lifetime depends linearly volume dependence becomes weak confinement regime size increases beyond radius demonstrate recombination faster compared nanoparticles volume suggesting stronger interaction confirm demonstrating increased binding energy reaches maximum fully three times larger quantum dots shift lead low threshold optical gain materials findings also suggest materials engineering reduce interaction lead improve prospects high efficiency devices core structures particular type nanostructures known reduce interaction applied goal increasing potential lighting applications
last decades reproductive medicine observed improvement management outcome pregnancy connective tissue diseases systemic lupus erythematosus sle syndrome however pregnancy related issues remain challenge patients routine clinical practice health professionals dealing sle need consider numerous aspects reproductive life patients pregnancy family planning fertility contraception cancer surveillance menopause new european league recommendations womens health family planning reflect need novel approach communication patient physician relationship counseling essential ensure optimal pregnancy outcomes careful risk stratification involving disease activity organ involvement profile use drugs previous pregnancy outcomes ensure better preventive therapeutic strategies limit complications patients stable inactive disease low risk thrombosis adequate hormonal contraception menopausal replacement therapy recommended assisted reproductive techniques safely used patients anticoagulation low dose aspirin added positive antibody titers women possibility preserve fertility releasing hormone analogues receiving agents strict clinical serological laboratory multidisciplinary monitoring pregnancy mandatory early recognize effectively treat disease obstetric complications doppler ultrasonography fetal regularly performed especially second third physicians recommend screening cervical dysplasia related human papillomavirus hpv infection especially immunosuppressive therapy hpv immunization used women stable inactive disease
paper presents evaluation performance two instrumented sections geosynthetic reinforced soil wall high constructed using fine grained soil two sections identical layout nonwoven woven geotextile monitored comparison purposes tensile stiffness nonwoven geotextile three times smaller woven geotextile allowed direct evaluation effect soil confinement geotextile stiffness instrumentation used measure face displacements reinforcement displacement strains soil rainfall occurred construction facilitated evaluation effect soil walls performance ultimate limit state analyses conducted gain insight performance two walls results show performance section reinforced nonwoven geotextile equivalent one reinforced woven geotextile even observed reduction rainfall sections overall deformations occurred construction negligible deformations observed service maximum face displacements measured lowest instrumented layer nonwoven geotextile section whereas highest layer woven geotextile section behaviours face displacement distributions result significant differences global stiffness sections design analyses field performance show soil confinement beneficial effect nonwoven geotextile stiffness significant contribution soil cohesion soil played important role behaviour nonwoven geotextile reinforced wall
silicon membranes compact geometry uniform pore size distribution demonstrated remarkable capacity advantages potentially used present initial evaluation mechanical robustness clearance parallel plate configuration mechanical robustness demonstrated exposing membranes high flows min pressures clearance performed albumin solution whole blood blood flow rates min evaluated using scanning electron microscopy immunohistochemistry hours porcine model pressure drop across flow cell min mechanical testing showed without fracture urea clearance show decline blood versus albumin solution studies showed blood successfully driven via arterial venous pressure differential without formation bare silicon showed increased cell adhesion fold increase fold increase polyethylene glycol peg coated surfaces tissue factor platelet adhesion respectively initial results warrant design development fully scaled based parallel plate renal replacement therapy
present study two novel dominant genera consortium confirmed used anode side microbial fuel cell reactor find influence cathode environment cell performance model terminal electron acceptor tea different used cathode side oxidation peak obtained corresponding cyclic confirms complete mineralization elemental accordance microbial community higher detrimental effect cell performance power density reduced half solution resistance found low high highest power density obtained buffering provided stability system lowest internal resistance comparable performance highest current density power density obtained aqueous developed consortium successfully utilized microbial fuel cells simultaneous electricity generation wastewater treatment elsevier rights reserved
compared hydrodynamic model non hydrodynamic model accurately simulate flows feature vertical accelerations models low computational efficiency severely wider application paper proposes non hydrodynamic model based parallel computing method horizontal momentum equation obtained integrating navier stokes equations bottom free surface vertical momentum equation approximated box scheme two step method used solve model equations parallel strategy based block decomposition computation utilized original computational domain subdivided two physically connected via virtual boundary technique two sub threads created computation two consumer model thread lock technique used achieve synchronous communication sub threads validity model verified solitary wave propagation experiments flat bottom slope followed two sinusoidal wave propagation experiments submerged parallel computing method proposed found effectively enhance computational efficiency save computation time compared serial computing parallel acceleration rate acceleration efficiency approximately respectively parallel computing method makes contribution non models
objectives study aimed develop performance assessment tool history taking components medical evaluation physical abuse young children determining consensus based injury history social components documentation identifying preliminary performance standards assessing current level specific performance using created tools evaluating reliability validity created tools methods physical abuse assessment tool developed steps modified delphi survey used identify injury history social components documentation medical evaluation physical abuse level specific novice competent expert practice standards minimum passing scores created using identified components via method evaluate validity reliability level specific performance chart review consecutive cases levels performed results seventy one child abuse pediatricians social workers participated modified delphi survey child abuse pediatricians social workers participated method resulting included use based presence absence history event one way analysis variance shows significant differences performance based team level indicating construct validity reliability evaluations showed strong moderate strong correlation coefficient correlations respectively conclusions initial evaluation suggests reliable valid practice assessment tool medical evaluation physical abuse
post translational modification proteins ubiquitin represents complex signalling system essential cellular functions including dna repair receptor signalling cell communication enzymes ubiquitin chains remove ubiquitin proteins central system reflecting complexity versatility ubiquitin signalling activity controlled multiple ways although several lines evidence indicate aberrant function promote human disease underlying molecular mechanisms often unclear considerable interest potential drug targets emerged past years future success based therapy development require connecting basic science function enzymology drug discovery present review discuss new insights activity regulation links disease focusing role regulators cell identity differentiation discuss potential emerging drug targets
pathogenesis irritable bowel syndrome ibs thought largely origin now understood multifactorial one reasons paradigm shift realization gut dysbiosis including small intestinal bacterial causes ibs symptoms patients ibs controls wide variations prevalence result population differences ibs diagnostic criteria importantly methods diagnose although quantitative culture considered gold standard diagnosis noninvasive hydrogen breath tests popular although glucose hydrogen breath test highly specific sensitivity low contrast early peak criteria hydrogen breath test highly nonspecific female gender older age diarrhea predominant ibs proton pump inhibitor intake low hemoglobin associated among ibs patients several therapeutic trials targeting gut microbes using antibiotics probiotics demonstrated symptoms patients ibs originate brain rather gut providing support micro organic basis ibs recent proof concept study showing high frequency symptom improvement patients ibs supports hypothesis
background polycythemia vera found wide range hematopoietic tissue disorders rarely concomitant renal abnormality knowledge one available report patient polycythemia vera concomitant renal report cover clinical course rare finding objectives report presentation clinical course patient polycythemia vera concomitant right renal methods retrospectively reviewed medical records patient polycythemia vera presented renal results patient presented right renal mass polycythemia vera diagnosed point mutation gene janus kinase mass diagnosed renal histopathology partial prescribed low dosage hydroxyurea without return year conclusions polycythemia vera responded low dosage hydroxyurea controlled removing renal mass
aspergillus opportunistic fungal pathogen primary causative species invasive systemic disease associated high mortality rates treatment invasive fungal infection relies limited number antifungal drug classes order extend spectrum antifungal drugs novel target structures identified mitochondria encounter structure recently discovered links mitochondria endoplasmic reticulum potential drug target based absence recently shown important fitness immune pathogenic yeast candida albicans studied role four core components pathogenic construction characterizing conditional mutants four core components deletion mutants show component significant importance growth fungal pathogen individual mutant phenotypes differed slightly components important maintenance mitochondrial morphology intra distribution characterization mutant infection model indicates contributes virulence results demonstrate pharmacologic inhibition exert antifungal activity important pathogen elsevier gmbh rights reserved
different clinical stages observed idiopathic parkinsons disease non motor symptoms define prodromal period particular whereas motor symptoms rigidity resting postural instability mandatory diagnosis important non motor symptoms olfactory dysfunction constipation depression sleep disturbances corresponding clinical course staging system neuropathological process starts enteric nervous system gut olfactory parkinson pathology cell cell transfer via sympathetic parasympathetic nervous system direction central nervous system reached typical neuropathological changes selective degeneration dopaminergic neurons substantia nigra formation lewy bodies reactive progressive central neurodegeneration appear evidence clinical pathological animal studies supporting hypotheses review article synuclein specific pathology found olfactory gland nucleus spinal cord dorsal motor nucleus nerve animal model mice treated chronically almost completely reproduce typical pathological clinical features development regional sequence
examine medication use among patients dementia towards end life evaluate appropriateness medication use using nationwide database national health insurance research database identified people dementia died person dementia data medication use last month outpatient setting month baseline last hospitalization hospitalization baseline death retrieved study medications interest selected according consensus recommendation included five categories defining appropriateness always sometimes rarely never appropriate consensus multivariable logistic regression carried analyze determinants use never appropriate medications study participants prescribed medications categorized never appropriate last month life outpatient settings significantly lower baseline month similar pattern identified last hospitalization death older age associated lower likelihood prescribed never appropriate medications age aor age aor contrast patients history diabetes mellitus aor associated higher likelihood prescribed never appropriate medications first study describe medications use particularly according appropriateness palliative care asian people dementia end life approximately patients prescribed never appropriate medications end life deserves study evaluate clinical impact quality care int
distributed generation deployed radial distribution networks changes steady state transient behavior analyze potential impact distribution network study models distribution network enhanced system particularly photovoltaic system digital simulation electrical network calculation program open distribution system simulator first case study study initially examines load models voltage regulators single three phase transformers provided adds single phase system ieee bus test compares steady state power flow solutions ieee bus test calculated calculated second case study study also models sufficiently complex number test distribution network developed used various fields analyzing steady state transient behavior enhanced distribution systems
clinical practice need individualized selection antidepressants adequate dosage investigation relevant genes promising approach assist selection past years two commercially available tests subject test analyses variants cytochrome test brain health analyses variants gene costs kits covered health insurance therefore proposed patients directly form individual healthcare payment companies claim applying tests antidepressant treatment failure avoided patients respond faster antidepressant used claims based appropriate clinical trials either lacking reveal conflicting results hence routine use tests recommended accordance german guideline depression therapeutic drug monitoring serum levels carried cases non response antidepressant adequate dosage duration rule costs covered health insurance cytochrome genotyping indicated serum level within expected range reasons explain discrepancy excluded many laboratories provide analyses individual cases costs health insurance research carried investigate importance gene treatment antidepressants
joints one common sites involved axial spondyloarthritis studies histopathology group patients mononuclear cell bone marrow fibrous tissue resembling formation pathological features early previous study undertook evaluation features patients biopsy specimens patients established ankylosing spondylitis patients axial spondyloarthritis analyzed method performed examine macrophages cells cells mononuclear cell bone marrow observed patients fibrous tissue observed patients established patients macrophage cell cell detected bone marrow fibrous tissue bone marrow specimens patients exhibited macrophage exhibited cell exhibited cell among fibrous tissue specimens exhibited macrophage exhibited cell exhibited cell addition macrophages cells cells also involved active patients
paper present new cryptographic primitive called policy controlled signatures notion sign message policies satisfies policies attached verify message type signature schemes many applications particular deal sensitive data want allow verify messages notion policy controlled signatures resembles similarities designated signatures also used signature multiple recipients nevertheless demonstrate notion policy controlled signatures generalize notion designated signatures concrete scheme secure model also provided furthermore also present extension universal policy controlled signature extended notion combine idea universal designated signatures policy controlled signatures allow flexible also provide concrete scheme secure model
high prevalence potentially traumatic events subsequent associated mental health problems impaired functioning need graduate training trauma psychology national survey conducted north american programs psychology ascertain current status training trauma training sent asked complete web based survey total responded adequate information program included analyses offered trauma psychology course specifically working populations commonly cited barriers addressing trauma limited capacity elective courses little time resources attention trauma issues important development competent professional psychologists ways programs facilitate development knowledge skills attitudes trauma psychology discussed
new voltage mode first order filter using three single ended operational transconductance amplifiers one capacitor proposed pole frequency controlled electronically adjusting transconductance value ota moreover realizing first order conditions component matching required characteristics proposed filter circuit also simulated using pspice simulations verify theory
solutions diffusion dominated motion single molecules conversely non ideal concentrated solutions mass transfer diffusion heavily influenced molecular clustering cluster theory concentrated solutions approached using model used explain experimental mutual diffusion data highly concentrated solutions work using model critical point theory starting point new model predictions mutual diffusion coefficients binary mixtures whole composition range developed model based modifications concentration correlation function explains experimental mutual diffusion data dependence composition activity coefficients model require knowledge intra diffusion coefficients used predict mutual diffusion coefficients whole composition range published elsevier
evaluate means longitudinal study radiographic involvement radio joints hand osteoarthritis relationship disease progression patients hand osteoarthritis enrolled patients underwent hand rays basis presence central joints patients divided three groups central one joint central erosion two joints central longitudinal study patients nine normal controls whose rays available years performed radiological involvement radio joints evaluated using scores low number joints showed values group group group low score values obtained radiographic items joint space score showed significant increase groups subsequent adjustment age gender bmi confirm statistical significance marginal rarely found joints radio radiographic per patient scores significantly worsened follow significant increase joints score found normal controls significant radiographic worsening found minority joints shows value lesser extent joints significant worsening follow joint involvement hand osteoarthritis mild progressive involvement negligible
test information theory prosocial behavior whereby utility self signaling effect consumption utility choice data come two field experiments involving consumer good donation across experimental cells price level donation level model free analysis data reveals regions demand good relatively large subjects also self report lower ratings feeling good offered large price evidence suggests price consumer self inference alternative motivation theories rejected due inability explain data moments standard use interaction effects explore underlying choice mechanism experimental setting complicated self signaling context instead novel feature analysis consists using experimental data estimate structural form model consumer demand self signaling specify model consumers obtain consumption utility choices utility derives consumers posterior self beliefs making choice estimator proposed handles potential arise self signaling model model estimates quantify economic role utility explore underlying signaling mechanism nested tests reject hypothesis self signaling alternative model specifications potentially allow demand without self signaling structure exhibit inferior fit data model estimates imply consumer response mainly driven utility consumption utility motives findings combination field experiment structural model contribute growing literature self signaling consumer behavior quantifying magnitude self signaling preferences choices results also implications design cause marketing campaign potential negative price
primer extension rna iii null mutant primer complementary gene revealed two major extension products two different extension products observed using rna either wild type null mutant primer complementary mapping ends extension products region indicated four putative transcription start sites preceded possible promoter sequences putative promoters synthesized pcr cloned based promoter probe vector transfer derivatives assays demonstrated four cloned fragments promoter activity vivo activities four promoters changed course growth studies three sigma factor mutant strains demonstrated three promoters sigma dependent northern blotting studies showed levels transcripts remained relatively constant course growth molar basis levels transcripts considerably lower cold shock protein activity promoters increased cold shock degrees resulting twofold increase activity compared activity degrees elsevier rights reserved
background multicentre trials investigating food allergies double blind placebo controlled food challenges need standardized procedures challenge meals evaluation criteria aimed developing standardized approach identifying patients related soy allergy means soy including determination threshold levels multicentre setting methods stable soy challenge meals composed protein isolate consistent levels patients sensitized main allergen bet concomitant sensitization soy underwent outcome defined according presence absence ten objective signs intensity eight subjective symptoms measured visual analogue scale vas results adult subjects female mean age years underwent challenge meals defined evaluation criteria showed good applicability centres involved presented objective signs subjective symptoms soy challenge placebo challenge meals elicited non cardiovascular objective signs subjects judged positive showed objective signs subjective symptoms soy challenge subjective symptoms soy challenge meal subjects started significantly lower dose levels objective signs median cumulative eliciting doses first objective signs subjects total soy protein first subjective symptoms conclusions present hitherto largest group adults bet sensitization investigated type food allergy evaluation outcome include monitoring objective signs also scoring subjective symptoms data contribute pollen related food allergy multicentre settings
objective present study compare group mediated cognitive behavioral physical activity intervention traditional exercise therapy upon select social cognitive outcomes sedentary knee osteoarthritis knee patients total patients mean age years women recruited using clinic community based strategies month single blind two arm randomized controlled trial mobility related self efficacy self regulatory self efficacy satisfaction physical function assessed baseline months results intent treat treatment time month analyses covariance yielded significantly greater increases relative partial correlations revealed changes significantly related improvements physical activity mobility months intervention yielded favorable effects important social cognitive outcomes effects related improvements physical activity mobility
introduction modern imaging aid diagnosis prognosis monitoring therapeutic response psoriatic arthritis psa detection technical advances like whole body magnetic resonance imaging mri exemplify value covered ultrasound provides clinic based tool evaluating joint pathologies extra articular structures especially enthesitis including skin nail disease recent studies demonstrated subclinical disease psoriasis without arthritis psa implications diagnosis treatment classification modern imaging also facilitate decisions expensive biologics though real world clinical studies still commentary increase novel psa therapies increase utilization modern imaging providing increased validation imaging biomarkers responsive outcome measures
certain drugs compounds potentially toxic practical importance assess predict potency process drug discovery classical quantitative structure activity relationship model developed using linear partial least square scheme understand underline mechanism non classical model derived using machine learning based hierarchical support vector regression predict compounds based series data observed performed better manifested predictions samples training set test set set various statistical mock test designated mimic real challenges also confirmed better performance furthermore exhibited superiority generalization capabilities consistent performance robustness compared various published predictive models conversely revealed mechanistically relationships descriptors thus two approach using predictive models synergistic fashion adopted facilitate drug discovery development designing safer drug candidates moiety elsevier ltd rights reserved
among population known black hole ray stands multiple ways continuous since shown wide range different states distinguished timing spectral properties states also observed past linked dynamics present first comprehensive study long term evolution using entire data set observed ray timing lifetime develop set descriptive features allowing automatic separation states show supervised machine learning form logistic regression random forests used efficiently classify entire data set first time explore duty cycle time evolution states entire time span find temporal distribution states likely changed span observations connect machine classification physical interpretations terms chaotic stochastic processes
simplified method plane analysis multi span suspension bridges proposed analysis model equivalent spring connected stiffness equivalent spring derived relation horizontal displacement restoring forces cables expressed simple formula stiffness deck considered also simplified method method suitable three suspension bridges also suspension bridge multiple example bridge two span length three indicates equivalent spring stiffness different load case significant large span suspension bridge equivalent spring stiffness mid small comparing side problem mid important side continuous suspension bridge multiple
double flow cavity attracted lots attention due importance many engineering fields ocean circulation crystal growth pollution transportation air metal manufacturing process heat mass transfer occur simultaneously double flow fluid flow driven temperature gradient also concentration gradient cases effects play significant role double flow process energy flux created concentration gradient called effect temperature gradient cause mass flux effect taking effects account temperature concentration equations become coupled however coupling matrix coupled system transformed two diffusion equations two independent species temperature concentration obtained inverse transformation two independent species numerical method developed past two decades lattice boltzmann method powerful simulating complex heat transfer fluid mechanics problems current study lattice boltzmann model developed implemented double convection effects three distribution functions used compute fluid velocity respectively specifically rectangular horizontal temperature concentration gradients investigated hand graphics processing units gpu computing becomes popular since advent cuda platform includes hardware components software programming environment developed code adapted cuda platform accelerate computation parametric studies gpu responsible parallel tasks cpu sequential steps computation verify improvement computation ability using gpu ratio computational time cpu code cuda code presented simulating classical natural convection process cavity computational speed accelerated times large number nodes used fluid flow temperature field concentration field presented different numbers ratios numbers numbers aspect ratios coefficients addition results numbers shown different parametric conditions result lattice boltzmann method demonstrated good option study complex double convection effects vertical cavity elsevier ltd rights reserved
paper studies evolution shaped influence injected flux scaling law wind tunnel experiment carried comparison experiment incorporates novel image processing algorithm recover evolutionary process theoretical experimental results agree middle stage evolution initial final stages suggesting shaped evolution intrinsically scale variant shape breaks unsaturated condition
background targeting positron emission tomography pet imaging labeled small molecule tracer crucial non invasive molecule imaging method apoptosis study semi automatic bis zinc potential small molecule tracer pet imaging cell death alzheimers disease model performed methods synthesized modified pet determined normal mice pet images model obtained micro pet scanner results modified total decay corrected yield within min results showed kidney highest uptake uptake brain kept relatively low level whole observed time vivo pet images demonstrated accumulation brain model mice brain normal mice conclusions semi automatic synthetic method provides slightly higher yield shorter whole synthesis time manual operation method improved method give enough high purity vivo pet imaging results show seems potential cell death tracer imaging
context health informatics play critical role supporting local health departments delivery certain essential public health services improving evidence base decision support however informatics capacities optimum level efforts build capacities face ongoing challenges moreover little known leaders future public health informatics objectives conduct qualitative analysis future informatics plans perceived barriers plans potential impact future advances public health informatics work public health enterprise methods research presents findings depth key informant interviews public health leaders informatics professionals representing insights across united states selected basis size population serves level informatics capacity interviews transcribed verified double coded results major barriers informatics included staff capacity training financial constraints dependency state health agency small size lack asked role leadership expanding informatics said leaders make priority learning informatics creating appropriate integrated information systems local health department leaders said desired data timely geographically specific addition leaders said desired greater access clinical data especially around chronic disease indicators conclusions local health department leadership timely even real time data local health departments great potential benefit informatics particularly electronic health records advancing administrative practices service delivery financial human capital represents largest barrier interoperability public health systems highly desirable hardly achievable presence barriers
recursive branch bound algorithms often used either rigorously non rigorously refine isolate solutions global optimization problems systems equations inequalities involving nonlinear functions presented software library integrates numeric symbolic computation generic framework solution problems hyper rectangular variable parameter domains correctness generic branch bound algorithm self validating methods used namely interval arithmetic polynomials rational functions expansion formally verified algorithm three main systems equations inequalities constrained global optimization computation bifurcation sets systems ordinary differential equations latter category enable computation heuristics reduce factor advantage taken partial derivatives constraint functions manipulated box subsets continuum solutions systems also produced capabilities software tool outlined computational examples presented
removal gear box existing electric vehicle power train incorporating direct drive topology expected improve motor wheel efficiency firstly paper discusses need novel direct drive scheme employing single board motor electric machine drive design targets direct drive scheme fixed based analytical equations benchmark data obtained commercially available motors drives transmissions literature study employing comprehensive vehicle dynamics model machine design targets previously fixed refined yield desired dynamic steady state performance urban drive cycle board direct drive surface permanent magnet synchronous machine fractional slot concentrated windings stator designed machines performance analyzed using electromagnetic model conjunction maximum torque per control scheme entire speed range motor results finite element analysis discussed detail show proposed direct drive scheme worth studying machine designed improved order obtain efficiency improvement system hence extend driving range
psoriasis chronic inflammatory disease affecting mainly skin complicated psoriatic arthritis psa autoimmune skin disorder concerns world population date psoriasis still completely elucidated many researches ongoing led example discovery pathway conventional therapeutic approaches local systemic route appeal various classes drugs complex mechanisms action non negligible side effects although therapy capable cure psoriasis current goal relieve symptoms longer possible good benefit risk ratio one principal limits conventional drugs new formulations based promising opportunity answer limit offering optimization conventional drug use higher activity lower side effects frequency application etc herein tried put perspective mechanistic insights histological immunological views proposed scientific literature last years order better comprehension psoriasis resulting skin lesions psa therapeutic different strategies management psoriasis discussed greater details finish field encapsulation nanoparticles order put forward recent advances innovative skin drug delivery systems active agents better efficacy safety compliance elsevier rights reserved
previous neuroimaging studies possible marker early schizophrenia patients reported inconsistent results addition remains unclear whether aberrant schizophrenia patients present associated cognitive impairment one core features schizophrenia magnetic resonance images obtained patients first episode schizophrenia healthy control subjects using software local index entire cortex compared groups relationship performance card sorting test also examined subgroup patients compared controls patients showed significantly higher wide range bilateral frontal regions right inferior parietal bilateral occipital regions number categories patients negatively correlated mainly middle frontal anterior cingulate regions right hemisphere findings suggested widespread pattern schizophrenia patients supported early neurodevelopmental abnormalities results also suggested executive dysfunction schizophrenia patients least partly related aberrant especially right frontal regions
dementia lewy bodies characterized synuclein accumulation degeneration dopaminergic cholinergic pathways gain overview brain systems affected neurodegeneration characterized fdg pet metabolic connectivity dementia lewy bodies patients compared healthy controls using sparse inverse covariance estimation method graph theory performed whole brain driven analyses targeting cholinergic dopaminergic pathways synuclein spreading first revealed substantial alterations connectivity indexes brain modularity configuration namely decreases local metabolic connectivity within occipital cortex thalamus cerebellum increases within frontal temporal parietal basal ganglia regions also long range among brain regions supporting disruption functional hierarchy characterizing normal brain driven analysis revealed alterations within brain structures early affected synuclein pathology supporting early pathological staging dementia lewy bodies dopaminergic cortical pathway severely affected cholinergic networks extensive decrease connectivity networks lateral network significantly towards occipital cortex altered patterns metabolic connectivity new scenario dementia lewy bodies underlying pathology terms changes whole brain metabolic connectivity spreading synuclein neurotransmission impairment
novel automated method determination based use pulsed flows developed applied determination element samples tap water ocean water eye drops method implemented means multi pumping system consisting three detector exploits reaction presence system runs control open source microcontroller main operational parameters optimized given particular kinetics reaction stopped flow period min included allow color development method presents linearity range good precision detection quantification limits respectively samples tap water eye drops successfully analyzed employing minute stop time providing maximum sampling frequency samples order overcome matrix effect caused high saline concentration ocean water samples required stop times min providing sampling frequency samples eye drops drinking water ocean water obtained method considered accurate fit purpose elsevier rights reserved
nowadays network control systems present common approximation connectivity issue solved based time delays coupling external factors however approach tends complex terms time delays inherent local phase missing therefore necessary study behavior delays integration onto differential equations bounded delays related time delays needs known dynamic real time behavior order understand dynamic phase behavior objective paper show way include data frequency transmission time delays bounded parameters dynamic response real time scheduling approximation considering local phase situation related control law designed considering fuzzy logic approximation nonlinear time delays coupling main advantage integration behavior extended state space representation keeping certain linear bounded behavior leading stable situation events presentation based accurate data transmission rate expected conform local phase missing result local bounded time delays lack synchronization modeling approximation
finite element mesh generators exist public domain even based parametric device description typical mesh generator requires man machine interaction define points boundary conditions work non stop optimization iterations need mesh dynamically evolving iterations optimization variables changing parameters mesh generators exist rare commercial easily available researchers except great cost never code modify suit individual needs take regular open source mesh generator write based interface open source run non stop optimization use create non destructive evaluation system ground vehicles defect characterization use equally machine design simple scheme averaging heights gives smooth geometry without use curves mesh runs central processing unit finite element optimization graphics processing unit speed testing times
objectives aim study study focal cerebellar pathology early stages multiple sclerosis using ultra high field magnetization prepared inversion contrast rapid gradient echo materials methods twenty early stage relapsing remitting patients underwent acquisition magnetic resonance imaging mri images acquired different resolutions mri total cerebellar lesion load volume cerebellar lesion volume compared across images using wilcoxon signed rank test mean relaxation times lesions normal appearing tissue contrast noise ratio measurements also compared using wilcoxon signed rank test multivariate analysis applied assess contribution mri metrics clinical performance patients results showed significantly higher lesion load compared plaques judged instead identified lesions cortical lesion significantly higher total lesion load total mean lesion volume obtained significantly predicted attention adjusted verbal fluency adjusted motor performance adjusted conclusions study demonstrates value study cerebellum early patients provides accurate anatomical description white gray matter pathology compared likely due improved spatial resolution lower partial volume effects higher
invasive fungal infections cause serious morbidity mortality among patients chemotherapy induced neutropenia order evaluate incidence treatment outcome factors associated patient population thailand retrospectively reviewed medical record patients admitted hospital january june criteria used diagnosed european organization research treatment cancer invasive fungal infections cooperative group national institute allergy infectious diseases study group consensus criteria three hundred ten episodes chemotherapy induced neutropenia occurred patients found episodes occurred patients received chemotherapy hematological malignancies incidence among patients hematologic malignancies commonly occurred aml patients patients received aggressive induction chemotherapy regimens aml highest incidence episodes probable possible related mortality clinical factor associated temperature degrees neutropenia higher mortality rate seen patients aged years serum albumin level
paper discuss development novel rapid prototyping method makes process creating tangible electronic artifacts faster easier method makes use new paper like material given form just hand using stationary objects material changes stiffness becomes soon modeling process furthermore material integrated within electronic circuits using magnetic silver discussed method conceptualized using people centered design approach implementation led engineering approach conceptualization process implementation discussed rapid prototyping method detailed paper along example scenarios said implementation useful
purpose paper adopt cmos image sensors achieve real time obstacle avoidance system mobile robots robot continually detect surroundings avoid obstacles move toward target area study cmos image sensor used detect small obstacles obtain information concerning environment front robot order avoid obstacles rolling speed direction robots left right wheels determined image channel weighting parameter method proposed study experimental results verified image captured cmos image sensor obstacle avoidance system mobile robot combined embedded microcontroller helps robot avoid obstacles reach target area
work presents comparative study two approaches calibrate radar rainfall real time weather radar provides continuous measurements real time errors either meteorological instrumental nature locally gauge measurements greater performance radar measurements used improve radar estimates one way via state space representation associated kalman filter algorithm modeling approach use linear calibration model applied multivariate state space model proposed used multiple site approach work aims discuss compare two different state space formulations based data set
contact problem exists widely mechanical engineering civil engineering manufacturing engineering etc extremely complicated nonlinear problem usually solved finite element method unlike traditional finite element method necessary set contact elements contact analysis different types contact elements joint elements cover surface contacted bodies zero thickness widely used however debates characteristics attached elements joint elements paper studies type matching attached elements results paper helpful finite element contact analysis
energy consumption commercial buildings represents around total energy produced north america total rated power small dry type transformers installed within typical large office building minimum typically loaded rated power running hours year efficiency values paper presents outcomes demonstration project considered smart configurations alternate existing methods project intended become one leed volume program design construction program operation maintenance launched usa canada green building design proposed paper box approach change traditional design power grids work demonstrated power flow within grid optimized dynamic reconfiguration power grid topology static dynamic loading leading improvement performance reducing power demand smart grid adapt optimum power flow human intervention paper also proposes new concepts designing distribution power grid within result reduction capital costs increase operational energy savings reduce maintenance costs
series analogues designed synthesized based structure small molecule plasma inhibitor protease domain led discovery potent inhibitor one
play critical role processes replication recombination double stranded dna mutations genes therefore devastating biological consequences humans mutations genes three members family give rise three strikingly distinctive clinical phenotypes syndrome syndrome syndrome respectively however molecular basis varying phenotypic outcomes unclear part full mechanistic description activity lacking core domains highly conserved postulated functional differences among family members explained significant differences terminal domains domains poorly characterized help fill gap now describe bioinformatics biochemical structural data three vertebrate proteins pair high resolution crystal structures analysis describe internal highly conserved sequence term helical bundle terminal domain show despite terminal domain structured potentially lacking defined three dimensional structure general exists structure required higher order assembly interestingly amplitude rate decrease assembled dimer also stable dimer upon atp hydrolysis thus structural biochemical terminal domains provide new insights terminal domain affects structural functional organization full molecule
beta beta known inducing intestinal allergies dysfunction neonates young pigs however underlying mechanisms largely unknown study clarify role autophagy beta induced cytotoxicity investigated effects beta cell viability autophagy activity porcine cells results indicated cell viability decreased increasing levels beta beta treatment enhanced per cells latter increased cells cultured conclude beta enhances autophagy activity
paper presents novel online tool robust pid controller design enables design robust pid controllers analyze stability closed loop control performance advanced way tool extension modular system complex framework provides features system identification pid controller design evaluation control quality extends possibilities framework control design tasks focused systems interval uncertainties tool allows user perform step step procedure system definition open loop analysis selection robust controller closed loop simulation evaluation control quality controller selection based partition method plant theorem extends also features enables perform polynomial approximation time delay systems paper also contains case study real laboratory process common usage procedure illustrated presented tool mainly intended education purposes field automatic control
concept autonomous farming concerns automatic agricultural machines operating safely efficiently without human intervention order ensure safe autonomous operation real time risk detection avoidance undertaken paper presents flexible vehicle mounted sensor system recording imaging data total six sensors full procedure sensors authentic data recorded case study grass harvesting human safety paper incorporates parts iso emerging standard safety highly automated machinery agriculture related human detection safety case study investigates four different sensing technologies intended dataset validate human safety human detection system grass harvesting study presents common algorithms able detect humans struggle handle lying humans high grass
battery based energy storage systems cell essential improve battery life cycle maximize capacity utilization however conventional cell require long durations accomplish cell balancing due power rating output current limitation high power application green building renewable energy electrical vehicles fast vital paper current fed full bridge topology proposed targeted fast cell compared conventional technology proposed topology applied high power application reduce time furthermore proposed topology requires fewer components cell algorithm based automatically switched maximum current voltage control introduced ensure battery cells work safely process minimize time proposed cell verified simulation experiment
lipid droplets universal cellular organelles transient long term storage lipids number size composition lipid droplets vary greatly within cells homogenous population different cell types variability intracellular lipid storage organelles reflects diversification lipid droplet composition function lipid droplet diversification results example two cellular lipid droplet populations prone diminish grow respectively aberrant accumulation depletion lipids hallmarks causes various human pathologies thus better understanding origins lipid droplet diversification fascinating cell biology question also potentially serves improve comprehension pathologies accumulation lipids commentary covers lipid droplet life cycle highlights early steps lipid droplet biogenesis propose potential driving forces lipid droplet diversification
precision low voltage important building blocks analog signal processing paper full wave rectifier based two bipolar systems threshold one inverter presented traditional approach based opamp diodes exhibits undesirable effects caused diode opamp pspice simulation results included
widespread utilization multicore processors operating systems face new challenges scalability lock mechanism used current monolithic makes critical modules encounter performance bottlenecks caused lock linux process lifecycle management results process creation execution termination scaling poorly core count increasing differing centralized fashion linux paper presents distributed process management model micro kernel better scalability kernel functions distributed message passing servers running different cores shared data including process control blocks page pools buffer servers actions including creation deletion page allocation loading scheduling parallelized without micro benchmarks show achieves nearly linear performance growth process outperforms linux core machine
need novel automated perception classification method becoming increasingly essential recent years increasing number borne diseases associated exist remote sensing gis based methods mapping potential inhabitants locations prone borne diseases methods generally account species wise identification closed regions traditional methods classification involve highly manual processes requiring tedious sample collection supervised laboratory analysis research work present design experimental validation automated vision based classification module deploy closed inhabitants module capable identifying extracting morphological features followed support vector machine based classification addition paper presents results three variants support vector machine classifier context classification problem vision based approach classification problem presents efficient alternative conventional methods surveillance mapping sample image collection experimental results involving classification predefined set using multiple classification strategies demonstrate efficacy validity proposed approach maximum recall
human studies demonstrate sleep impairment concurrent comorbidity autism spectrum disorders asd etiology remains largely uncertain one prominent theories asd suggests imbalance synaptic excitation inhibition contribute various aspects asd including sleep impairments following identification mutation patients asd effects synaptic transmission social behaviours examined extensively mouse model however role mutation sleep impairments asd remains unknown study showed knock mice established genetic model asd exhibited normal duration distribution sleep wake states significantly altered electroencephalography eeg power spectral profiles wake sleep
objective using national survey childrens health data set compared partner relationships parent child relationships family relationships parenting stress childrens general health emotional difficulties coping behavior learning behavior child outcomes households sex female versus different sex continuously coupled parents biological offspring assessed whether associations among family relationships parenting stress child outcomes different household types methods parental child characteristics matched female sex parent different sex parent households children years old one parent per household interviewed telephone multivariate analyses variance multiple linear regressions conducted results differences observed household types family relationships child outcomes sex parent households scored higher parenting stress confidence interval different sex parent households confidence interval significant interactions household type family relationships household type parenting stress found child outcomes conclusion children female sex parents different sex parents demonstrated differences outcomes despite female sex parents reporting parenting stress future studies reveal sources parenting stress
lung transplant recipients associated severe outcomes less frequent cause symptomatic characterized cytoplasmic inclusions within circulating neutrophils report case infection recipient diagnosed blood exam confirmed molecular studies
indications liver transplant extended older patients undergoing transplantation infectious malignant cardiovascular diseases account deaths patients develop heart disease systemic diseases affecting heart liver cirrhosis specific heart disease common cardiovascular single factor predict cardiovascular complications patients history cardiovascular disease specific abnormalities echocardiography serum markers heart disease seem increased risk complications pre transplant cardiovascular evaluation essential detecting risk factors effects mitigated appropriate intervention
intentional childhood poisoning uncommon child abuse high risk morbidity mortality patients present four main categories illness metabolic salt water ingestion gastrointestinal symptoms poisoning hemorrhagic disease warfarin exposures neurologic symptoms central nervous excitation widely available routine urine drug screens limited value clinicians high index suspicion make diagnoses
research gastrointestinal digestion milk strongly suggests existence novel bioactive peptides antiviral activities attributable effects present study investigated antiviral activity peptides rich phosphate groups iii prepared two types different phosphorylation levels clarify role phosphate group phosphorylation iii conducted dry heating sodium whereas performed using alkaline phosphatase alkaline treatment strain typical surrogate kidney cells used target virus host cells respectively antiviral activity determined based bromide assay quantitative polymerase chain reaction quantification antiviral cytokine mrna expression higher cell viability observed host cells treated phosphorylated iii significant regulation type interferon expression induced compared treated native iii however iii resulted decrease anti effect conclusionthe effect enhanced introduction additional conversely weakened elimination therefore iii phosphorylation represents emerging approach production food grade antiviral agents society chemical industry
extraction high molecular weight chromosomal dna yeast cells procedure performed frequently experiments involving polymerase chain reaction pcr southern blotting dna analysis techniques investigated several parameters affecting dna yield quality using simple chemical based purification procedure modelled alkaline methods developed bacterial cells three major steps procedure cell protein removal dna precipitation optimized testing impacts several chemicals including sodium sds sodium buffer sodium acetate potassium acetate parameters effect elevated temperatures cell also investigated rapid optimized protocol derived purification dna small cell cultures readily digested restriction enzymes used template pcr average yield calculated approximately dna cells similar theoretical maximum amount yeast cells copyright john wiley sons ltd
food supply consumption critical sustaining urban system functions key determinants quantity pathways nutrient flow cities nutrient elements urban food consumption becoming major pollutant sources urban environments therefore understanding flow magnitude pathways role growing population changing dietary structure technology future nutrient metabolism essential understand cities ecosystems urban environmental management taking city rapid area southeast china case study simulated urban metabolism three major food nutrient elements carbon nitrogen phosphorus environmental emissions impacts future population growth dietary habit change waste treatment improvement various environments forecast scenario analysis sensitivity analysis conducted test different waste treatment technologies affect environmental emissions food nutrients results show food various metabolic fluxes urban systems carbon mostly emitted air nitrogen phosphorus mostly discharged water population growth dietary structure change accelerate increases nutrient emissions environment whereas enhancing current waste treatment technology just alter emissions different environments based results discuss food nutrient metabolism better managed enhance connectivity cities maintain environmental emissions within carrying capacity cities published elsevier ltd
kinase related protein kinases key regulators controlling wide range cellular events yeast complex humans play pivotal roles dna replication dna damage signaling repair present first structural insight using single particle electron microscopy kinases reveal head head dimer one major interface terminal heat named elongation factor protein phosphatase yeast kinase repeat interface significantly distinct interface mtor complex dimer two spatially separate interfaces also observe different structural organizations kinase domains kinase domains dimer located close proximity however dimer fully separated providing potential access substrates kinase even form
article use fractional complex transformation convert nonlinear partial fractional differential equations nonlinear ordinary differential equations algebraic method improved construct uniformly series exact solutions nonlinear time space fractional partial differential equations construct successfully series exact solutions including elliptic doubly periodic solutions aid computerized symbolic computation software package maple method efficient powerful solving wide classes nonlinear partial fractional differential equations elliptic doubly periodic solutions generated trigonometric exact solutions hyperbolic exact solutions modulus respectively
theory network reliability applied many complicated network structures computer communication networks systems electricity networks traffic networks theory used evaluate operational performance networks modeled probabilistic graphs although evaluating network reliability non deterministic polynomial time hard problem numerous solutions proposed however based sequential computing utilizes benefits multi core processor architectures paper addresses limitation proposing efficient strategy calculating two terminal terminal pair reliability binary state network uses parallel computing existing methods analyzed efficient method calculating terminal pair reliability based logical probabilistic calculus proposed finally parallel version proposed algorithm developed first study implement algorithm estimating terminal pair reliability parallel multi core processor architectures experimental results show proposed algorithm parallel version outperform existing sequential algorithm terms execution time copyright john wiley sons ltd
already triggered enormous researches areas solar energy transfer environmental purification organic synthesis etc work photocatalytic reactions applied prepare nanostructured hybrids highly distributed active components loading rapidly achieved redox reactions electrons three steps involved formation hybrids namely oxidation holes deposition intermediate finally decomposition form selective catalytic reduction chosen model reaction explore application found unique hybrids exhibited promoted low temperature performance compared prepared via attributed abundant species surface active oxygen surface species acid sites believe hybrids also interested applications environmental catalysis elsevier rights reserved
background small size focus breast magnetic resonance imaging mri evaluated basis characteristics features patient related factors including patient age conjunction lesion related factors useful decision making purpose assess probability malignant foci based lesion patient related factors propose relevant decision making method material methods foci breast mri database dating april june retrospectively identified analyzed fishers exact test mann whitney test performed univariate analyses factors showed significant association outcome univariate analyses subjected multivariate analysis using logistic regression model decision tree drawn using significant predictors confirmed multivariate analysis results total foci benign malignant patients analyzed study presence pattern older age found significant predictors malignancy years conclusion enhancing focus showing pattern especially older patients warrant immediate biopsy rather short interval follow
four studies tested hypothesis weaker belief free related feeling less studies trait measure free belief positively correlated measure study participants whose free belief weakened unchanged reported feeling less events past study used laboratory induction participants experimentally reduced increased belief free reported feeling less favor study reduced increased belief free led less hypothetical favor scenario effect mediated perceiving less free therefore less motivated findings suggest belief free important part able feel
background obesity multifactorial condition influenced genetics lifestyle environment objective investigated whether association validated genetic profile risk score obesity obesity body mass index bmi waist circumference modified sleep characteristics design study included cross sectional data white european adults aged participating interactions obesity sleep characteristics sleep duration day shift work effects bmi investigated results beta values expressed change bmi per increase obesity obesity associated bmi beta significant interactions obesity variety sleep characteristics relation bmi interaction participants daily effect obesity bmi stronger beta respectively normal length beta similar pattern observed shift workers beta compared beta non shift workers night shift workers beta compared beta non night shift workers taking day beta compared beta never rarely self reported evening beta compared beta morning similar findings obtained using outcome conclusion study shows association genetic risk obesity phenotypic adiposity measures exacerbated adverse sleeping characteristics
background dental health care professionals play important role mandated advocates health care neglect suspected children however confusion around constitutes child neglect methods authors reviewed dental literature descriptors definitions neglect studied individual state learn protection afforded victims neglect health care providers acting behalf children also reviewed methods action address suspected neglect results authors found confusion around child neglect yet dental professionals law moral code protect children neglect authors offer definition neglect suggested practice guidelines assist practitioner acting childs advocate conclusions clinicians use strategies address problem child neglect digital data treatment registry provide additional views childs health status practical implications better understanding definition neglect strategies implemented use dental team address problem neglect reduce incidence
school classic optimization problem extensively studied due practical theoretical importance consists scheduling set class teacher meetings predetermined period time satisfying requirements different types given combinatorial nature problem solving medium large instances optimality challenging task resources tight often difficult find even feasible solution several techniques developed literature tackle high school problem since use exact methods mathematical programming techniques considered solve large real world instances hybrid used solution approaches paper propose multi commodity flow model high school problem addition apply decomposition proposed model propose column generation algorithm present experimental results known instances problem results show lower bounds obtained approach tight generated faster previous approaches reported literature elsevier rights reserved
prostaglandin natural lipid derived molecule involved important physiological functions abnormal signalling associated pathologies nervous system previous studies provide evidence interaction canonical wnt signalling pathways non neuronal cells since wnt pathway crucial development organization brain main goal study determine whether collaboration pathways exists neuronal cell types report interacts canonical wnt signalling stem cells used time microscopy determine increases final distance origin path length average speed migration wnt activated cells furthermore alters distinct cellular phenotypes characteristic wnt induced cells corresponds modified splitting behaviour cells also found wnt induced cells level beta catenin protein increased expression levels wnt target genes significantly upregulated response treatment confirms activated canonical wnt signalling pathway furthermore upregulated genes previously associated asd findings show first time evidence cross talk wnt signalling neuronal cells act mediators two pathways given importance wnt signalling prenatal development nervous system study provides insight interaction two pathways influence
game science become research field industry attention due worldwide rich market understand player experience concepts like flow mental states require empirical investigation taking advantage objective data methods like electroencephalography eeg provide work studies affective shows two different game levels developed aim manipulate emotions two sets affective design guidelines presented rigorous considers characteristics role playing specific empirical investigation brain computer interface conducted extracting numerical data features machine learning techniques classify different activities gaming sessions task events verify design differentiation affective one observed results also supported subjective questionnaires data confirm proposed guidelines suggesting evaluation methodology extended evaluation tasks
context research shown majority real faults complex simulated traditional first order mutants higher order mutants created making multiple changes source code combining multiple potentially used simulate realistic faults objective goal find subtle define reference test suite subtle represent cases single faults interact produce complex faulty behavior fault detection effectiveness test suite improved adding test cases detect subtle method developed six search based techniques find subtle genetic algorithm local search data interaction guided local search test case guided local search restricted random search restricted performed empirical studies evaluate ability search techniques find subtle investigated factors impact characteristics subtle results local search guided local search techniques effective techniques finding subtle majority subtle found resulted combining mutated java primitive operators conclusions proposed techniques able find subtle subtle lower degrees effective way finding new subtle higher degrees elsevier rights reserved
although known examples specific processes shape population structures examined detailed sampling fast evolving genetic markers combination model based clustering methods study aims analyse impacts isolation within expansion population structure northern also discusses role processes edges species distribution evolutionary history inherited mitochondrial control region inherited nuclear used examine samples within central europe adjacent islands bayesian inference tests proposed recent increase population size pronounced pattern population structure involved differentiation populations mediterranean sea population within contact zone central europe hybrid detected first time central europe low genetic diversity observed highest genetic distances among individuals found recent population post area related shows complex pattern pronounced subpopulations located mainly basin detailed analyses indicate factors limit range expansion also strong forces change genetic structure species present evidence showing population differentiation occur restriction range also range expansion population differentiation adjacent regions ascribed diversification forest complicated including pronounced geographic barriers
high incidence esophageal cancer northeast india unique ethnic background dietary habits provide great opportunity study molecular genetics behind esophageal squamous cell carcinoma part region hypothesized addition currently known environmental risk factors esophageal cancer genetic epigenetic factors also involved esophageal carcinogenesis northeast india therefore study explored possible association two important cell cycle regulatory genes environmental risk factors risk esophageal carcinogenesis total newly diagnosed esophageal cancer cases along equal number age sex ethnicity matched controls included study methylation specific polymerase chain reaction used determine promoter methylation status single nucleotide polymorphism codon gene assessed polymerase chain reaction restriction fragment length polymorphism method aberrant methylation gene seen esophageal cancer cases gene found healthy controls pro pro genotype found risk genotype northeast india compared pro variant polymorphism significantly associated esophageal cancer risk study population three genetic models namely dominant model pro pro pro odds ratio confidence interval recessive model pro pro pro odds ratio confidence interval homozygous model pro pro odds ratio confidence interval however variant polymorphism statistically associated esophageal cancer risk heterozygous model pro pro pro case analysis based methylation variant polymorphism pro pro pro showed significant association esophageal cancer risk odds ratio confidence interval gene gene gene environment interaction using case approach revealed strong association methylation single nucleotide polymorphism environmental factors esophageal cancer risk cases methylation variant polymorphism pro pro pro along tobacco habit odds ratio confidence interval conferred increased risk toward esophageal cancer development study reveals synergistic interaction epigenetic genetic environmental factors risk esophageal cancer high incidence region northeast india inactivation either majority esophageal cancer cases study suggests possible crosstalk important cell cycle genes
quantification gene expression provides valuable information regarding response cells tissue stimuli often accomplished monitoring level messenger rna mrna transcribed particular protein although numerous methods commonly used monitor gene expression including northern blotting real time polymerase chain reaction protection assay method drawbacks limitations capillary electrophoresis laser induced fluorescence reduce protocol time eliminate need provide superior sensitivity dynamic range quantification rna addition used directly determine amount rna species present something difficult normally accomplished using current methods gene expression detected using labeled specific given rna species direct approach validated analyzing levels rna also used determine amount domain receptor mrna cardiac tissue elsevier inc rights reserved
green energy gained significant research attention across globe due ability reduce environmental damage however complete acceptance green energy government regulations enough willingness use green energy contribute wellbeing environment spring within consumers willingness developed enhancing consumers perceived value green energy however order necessary assess existing levels consumers perceived value towards green energy present study develops multidimensional green perceived value scale measure existing levels consumers perceived value scale considers green perceived value multidimensional second order construct comprising functional value social value conditional value emotional value dimensions attempt made highlights originality value present study scale used assess consumers perception towards green energy information help strategies encourage consumers adopt green energy study also reveals financial aspects lead consumers decide adoption green energy consumers also driven emotional social considerations thus policy makers formulate pro green energy programmes mass messages appeal consumers sense responsibility adopt green energy without rely financial incentives researchers examine considered dimensions scale respect constructs related consumer behaviour elsevier ltd rights reserved
microwave powered cold plasma treatment investigated intervention technology improving microbiological safety var salmonella approximately log cfu tomato subjected using oxygen gas mixture min plasma generation power central composite method applied investigate interactions treatment conditions salmonella reduction rate weight loss temperature using gas mixture min resulted greatest reduction salmonella numbers log cfu tomato respectively temperature increases degrees respectively min determined optimal conditions salmonella inactivation study influence surface morphology optimal effectively inhibit growth salmonella degrees treatment prevented salmonella growth storage degrees without affecting tomato respiration rate results demonstrate potential technology improve microbiological safety salmonella without affecting biological properties elsevier rights reserved
dense buildings major factor affecting urban flood routing currently study urban dam break flood routing primarily focuses simplified terrain model shallow water equations ignore effects dense urban buildings furthermore complex interactions dam break wave wall surfaces buildings reflected results tackle problems three dimensional flood routing high precision digital model urban area studied paper firstly vector data various land types extracted remote sensing image algorithm based tin algorithm introduced construct three dimensional terrain model coupled vector data terrain model three dimensional digital model urban area established next three dimensional epsilon turbulence model proposed flood routing simulation grid second order accuracy discrete format used divide digital model urban area governing equations solved using algorithm finally superiority mathematical model computational efficiency mesh model validated according urban flood routing experiments urban reservoir located city china modelled show dam break flood urban area exhibits significant three dimensional characteristics moreover due surrounding buildings flood exhibits complex three dimensional turbulence phenomena including collision reflection
objectives study association clinical ultrasound variables patients physicians global assessment disease activity psoriatic arthritis psa correlation parameters changes months also investigated methods prospective study consecutive psa patients visits scheduled months apart patients underwent following assessments joint count enthesitis index patients level pain pain vas also recorded grey scale power doppler ultrasound performed joints evaluating regression analyses performed assess association variables two new variables developed explore discrepancy consistency changes time respectively results parameters explaining variability pain vas respectively correlation joint counts stronger patients high low levels ultrasound verified inflammation mainly explained pain pain important predictor change whereas closely associated changes linked pain ultrasound scores linked either variables conclusions pain vas joint counts important clinical parameters explaining patients physicians perception disease activity whereas correlation active inflammation verified factors limited elsevier inc rights reserved
background safety hpv vaccines still question due reports autoimmune diseases ads following hpv immunization objectives assess risk ads associated hpv vaccination female adolescents young adults france methods systematic prospective case study conducted assess risks associated real life use hpv vaccines cases female years old incident ads central demyelination multiple sclerosis connective tissue disease syndrome type diabetes autoimmune thyroiditis idiopathic cases consecutively prospectively identified specialized centers across france individually matched age place residence recruited general practice risk computed using multivariate conditional logistic regression models adjusted family history ads living france north south medications results total definite cases matched ads combined negatively associated hpv vaccination adjusted odds ratio confidence interval similar results obtained last two reaching statistical significance association found sensitivity analyses combining definite possible cases secondary time window showed similar results conclusion exposure hpv vaccines associated increased risk ads within time period studied results robust case definitions time windows exposure continued active surveillance needed confirm finding individual ads authors published elsevier ltd
frontotemporal dementia second common dementia years age gene accounts cases familial mutation carriers increased risk autoimmune disorders accompanied elevated levels tissue necrosis factor tnf alpha examined behavioral alterations related obsessive compulsive disorder role tnf alpha related signaling pathways patients mutations mice lacking found patients mice mutations displayed self like behavior mice respectively furthermore medium neurons nucleus area implicated development display knockout mice reducing levels tnf alpha knockout mice abolished excessive self associated medium neurons nucleus brain highly expressed microglia major source tnf alpha therefore specifically microglia found sufficient induce excessive importantly excessive mice prevented nuclear kappa microglia myeloid cells findings suggest deficiency leads excessive kappa activation microglia elevated tnf alpha signaling turn lead medium neurons like behavior
biosynthesis thought resemble metabolite essential metabolism eukaryotes arises initial condensation two molecules form undergoes rearrangement form principle arise alternative rearrangement intermediate proposed similarities predicted synthase resemble synthase hence isolated synthase like genes race least one typical synthase none three synthase like genes encodes biosynthesis directly catalyzes biosynthesis biosynthesis ether appear able directly utilize substrate however combinations synthase like enzymes mixed together vivo vitro robust biosynthesis observed findings unexpected synthase ancient likely progenitor catalyzes two step reaction within single enzyme unit without intermediate release yet activities appear separated evolved specialized oil production greater genes different configurations independent genes gene targeted intracellular membranes also demonstrate potential engineering even greater efficiencies biosynthesis
background assessment pituitary mass objective visual field testing represents valuable means evaluating mass effect thus deciding whether surgical management warranted case presentation describe year old presented three week history frontal headache left side vision due grade iii optic report timely investigations including based visual field test rapid field conducted aided appropriate management patient conclusions test role assessing bed bound patients hospital access formal visual field testing difficult indeed rapid testing visual fields screen postoperative complications
nanocomposite electrical generator composed zinc oxide zno modeled using continuum mechanics equations axial loading considered optimum aspect ratio zno getting maximum electric potential calculated bonding zno polymer matrix considered perfect linear piezoelectric behavior assumed shown electric potential maximum minimum values opposite signs extreme ends along length maximum generated electric potential varies aspect ratio one aspect ratio thirty optimum aspect ratio zno defined difference maximum generated electric potential difference becomes less results aspect ratio results major step toward producing zno nanocomposite electrical generators maximum performance
objectives human cell virus type infection associated neurological abnormalities associated tropical peripheral neuropathy hepatitis virus hcv infection leading cause chronic liver disease worldwide causes approximately patients interplay potentially viruses individual still poorly understood clinical laboratory outcomes infected patients evaluated compared controls methods prevalence rates neurological laboratory abnormalities evaluated hcv infected patients subjects single hcv infection results higher frequency isolated present hcv infected patients associated difference found frequency infected subjects compared infected subjects hepatic involvement present hcv infected subjects shown increased levels serum alanine aminotransferase aspartate aminotransferase gamma transferase addition thrombocytopenia hand hcv infected individuals presented better prognosis hepatic involvement compared hcv infected subjects conclusions data suggest hcv infection alter outcome regard neurological manifestations nonetheless changes immunological environment induced infection lead reduction hepatic damage even without significant hcv clearance published elsevier ltd behalf international society infectious diseases
normal digestive tract microbiota plays essential role maintaining homeostasis normal development digestive tract metabolism immunity angiogenesis treatment antibiotics especially children often associated significant changes intestinal microbiota lead intestinal probiotic bacteria used century promote digestive health objective study investigate probiotic strains isolated infants studying influence expression antibiotic resistance strains recently isolated digestive tract infections study demonstrates probiotics associated antibiotics increase susceptibility beta plus acid
article chip self calibrated bit digital analog converter dac based digitally compensated input offset operational amplifier opamp presented improve overall dac performance digital offset cancellation method used compensate deviations input offset voltage opamp caused process variations whole dac offset compensation circuitry designed standard cmos process achieved results show self calibration process improvement value dac offset error achieved
light current situation water resources egypt deficit resources rainwater harvesting assessment became necessary present study attempt made define decision based scientific approach identifying appropriate sites rainwater harvesting approach based gis data layers include setting watershed area rainfall amounts drainage lines morphometric parameters flow accumulation flow direction slope surface runoff also includes verification site suitability field investigations area chosen lack water agriculture drinking purposes addition area special interest planned nuclear power plant obtained results reveal study area contains eight basins slightly intensive drainage network morphometric analyses studied basins reveal opportunities surface runoff three showing high hazard degrees basins actual runoff ranges annually resulted average rainfall therefore management rainwater harvesting flash floods recommended many rainwater harvesting structures example dams alternative earth surface water reservoirs established
chip gene expression analysis droplets developed detection cancer cells single cell level chip consists shaped reaction chamber hydrophobic modification employing magnetic droplet handling system gate separation using three kinds water based droplets oil droplet sample cells buffer magnetic beads pcr buffer parallel magnetic manipulation fusion droplets performed using magnet handling device containing small external magnet patterns array actuation magnet offers simple system droplet manipulation allows separation fusion droplets containing magnetic beads reverse transcription amplification thermal cycling fluorescence obtained detection overexpressing genes clinical detection gastric cancer cells peritoneal washing overexpressing gastric cancer cells spiked within normal cells detected gene expression analysis droplets containing average cells developed droplet based cancer detection system manipulated external magnetic force without pumps valves offers simple flexible set transcriptional detection cancer cells greatly advantageous less invasive clinical diagnosis prognostic prediction
shock tube rapid compression machine used measure new ignition delay times methanol oxidation wide range pressures equivalence ratios measurements include fuel air conditions methanol temperature range new data compared previously published studies provides insight internal combustion engine relevant conditions previously studied pressures addition ignition delay times species concentrations also measured using jet reactor experiments methanol concentrations ppm used equivalence ratios pressures temperature range residence times varying newly measured experimental data used develop new detailed chemical kinetic model model also validated using available literature data new model capable predicting validation data reasonable accuracy discrepancy predicting formaldehyde data results robustly validated accurate new detailed chemical kinetic model combustion institute published elsevier inc rights reserved
aim study association country birth incidence different immigrant groups sweden study population included whole population sweden defined least one registered diagnosis national patient register association incidence country birth assessed cox regression hazard ratios hrs confidence intervals using swedish born individuals models conducted men women full model adjusted age place residence sweden educational level marital status socio economic status morbidities risk varied country origin highest estimates compared swedish born fully adjusted models among men russia also high among men poland africa asian countries outside middle east among women africa also high among women poland risk lower among men greece spain countries except finland latin america among women southern europe compared swedish counterparts increased risk among several immigrant groups likely explained high metabolic risk factor pattern needing attention
first family satellites designed provide data stream european environmental monitoring program known specifically designed perform land advanced differential synthetic aperture radar analyses investigation surface displacements particular day revisit time innovative acquisition mode referred terrain observation progressive scans fundamental guaranteeing global spatial coverage contributing creation framework exploitation big data earth observation applications paper present efficient automatic implementation parallel small baseline subset algorithm specifically intended processing sar data algorithm able run distributed computing infrastructures effectively exploiting large number resources allows generation ground displacement time series aim paper show possible automatically continuously process short time frame large sequences data thus allowing perform advanced analyses unprecedented large scale addition proposed algorithm also tested commercial public cloud computing platforms provided amazon web services presented processing chain suited build operational services easy rapid generation advanced products useful scientific purposes also risk management natural hazard monitoring authors published elsevier
objectives syndrome low prevalence life threatening disorder characterized hepatic venous outflow obstruction hepatic large hepatic veins inferior right liver transplant considered patients chronic forms syndrome materials methods fourteen patients received liver center september march study reviewed prospectively collected data patients results mean age patients years patient female severity liver disease child score patient patients patients mean calculated model end stage liver disease score range cause syndrome factor mutation patients polycythemia vera patients factor deficiency patient essential patient protein deficiency patients performed patients five obtained donors living related donors mean graft recipient weight ratio patients receiving living donor liver transplant median follow months patient survival rates years conclusions liver transplant option treating syndrome cases presentation cirrhosis living donor liver trans plant viable choice countries organ still problem manage long term medical therapy follow patients careful evaluation necessary determine cause syndrome anticoagulant therapy remains mainstay treatment syndrome
sustainable water management important global action alleviate growing pressure water resources way balance socio economic environmental water needs irrigation green roofs urban green infrastructures often negative water management context especially case semi arid regions water scarcity summer water needs compromise public support urban irrigation systems however green roofs also beneficial improves plant survival temperature control information green roof irrigation still scarce review attempts draw attention alternative water sources water conservation strategies order make green roof irrigation practices sustainable suggestions sustainable green roof irrigation showed water conserved adapting irrigation requirements targeting vegetation materials using alternative irrigation sources gray water rainwater harvesting controlling monitoring irrigation regimes based deficit irrigation strategy irrigation specifications green roofs different climates proposed became clear irrigation essential establishment first growing season types green roof climates considered afterwards irrigation necessary green roofs semi arid climates advised small amounts climates public awareness sustainable water consumption promoted green roofs designed carefully irrigation practices sustainable long term contribute better urban life quality elsevier ltd rights reserved
looking beyond approach green rating systems apply north american climatic criteria brazilian context environmental design faculty architecture university advocates far reaching way forward sustainability brazil
article examines coordination speech gesture teachers definition talk vocabulary explanations addressed language learners analyzing one teachers definitions study demonstrates details talk teacher definitions moment moment attending students linguistic needs study draws upon notion gesture speech idea cohesion notion turn gesture study identifies three major functional roles gesture reinforcing meaning verbal meaning items establishing cohesion across turns talk fine grained analysis five study contributes understanding informational aspects gesture second language teaching article discusses implications study gesture general role providing input second language learners particular
hospital perhaps site history british art therapy associated key figures whose work involved setting large psychiatric patients create expressive little known however work designated psychiatric research charged overall scientific analysis products biological psychiatric tradition prior hospital committed treatments electro therapy unusual candidate research processes behind art psychosis yet two highly popular widely reviewed books analyses abundant output created patients diagnoses psychotic art art culture compared images produced influence examined output patients undergone article draws materials original research publications order reconstruct theory art within complex context british psychiatry biologically understandings categories ultimately synthesizing concepts also analyses implicit theory therapeutic mechanism art treatment psychiatric patients
experiment conducted investigate effects dietary fibre content weaning age oil clostridium proliferation mortality growing rabbits facility rabbit experiment consisted factorial arrangement two weaning ages days days two levels dietary neutral fibre assayed heat stable expressed exclusive residual ash controls made two consecutive experimental periods differed environmental conditions modifying intensity cleaning farm previous trial interaction detected among independent variables studied contents minimal values trait obtained non animals clean environment especially later age fed diet lower fibre content treatments studied also led variation mortality highly positively correlated average counts combination treatments results current study indicate high counts used indicator rabbit suggest strategies designed control proliferation help limit mortality rabbit fed diets antibiotics elsevier rights reserved
background evidence based practice implementation represents strategic change organizations requires effective leadership alignment leadership organizational support across organizational levels need combining leadership development organizational strategies support organizational climate conducive implementation leadership organizational change implementation loci intervention includes leadership training leaders ongoing implementation leadership coaching degrees assessment strategic planning top middle management regarding support leaders developing positive implementation climate methods test loci intervention take place conjunction implementation motivational interviewing substance use disorder treatment programs california usa participants include agency program leaders approximately treatment staff loci tested using multiple cohort cluster randomized trial programs within agency either loci leadership training control condition three consecutive cohorts loci intervention months control intervention takes place months cohort web based surveys staff used collect data leadership implementation climate provider attitudes audio recordings counseling sessions coded fidelity unit analysis randomized site within agency care taken located assigned condition avoid contamination hierarchical linear modeling used analyze data account nested data structure discussion loci developed feasible effective approach organizations create positive climate fertile context implementation approach seeks sustain effective general implementation leadership organizational strategies support remain study ended development positive implementation climate result positive service provider attitudes behaviors related use ultimately higher fidelity use
computer graphics advent latest technology last decades paper framework used create virtual university web virtual designed provide viewers life like view existing location using advanced simulation techniques creating loading manipulating objects tool models built converted format achieved use objects file moreover tested especially loading simple average complex objects without texture system capability support multi users navigation virtual environments
study empirically tested effects use third person perceptions context stock market using sample professional stock members lay public findings show people perceived anonymous information internet greater influence others additionally participants demonstrated third person perception others novice little knowledge experience stock trading others presumed experienced professional stock perceived greater influence others lay public also found support relationship third person perceptions attitudes toward support anonymous information
veterans health administration mandated nationwide implementation team based care general mental health setting endorsed collaborative care model guide coordinated care delivered teams front line clinic staff major stakeholders whose practices directly affected implementation view teams useful feasible practice objective examine perspectives delivering team patient care order understand system level efforts best support transition care conventional provider patient care conducted semi structured interviews staff general mental health clinics across three different medical facilities interview questions focused asking care delivered clinic experiences staff clinic handles changes four recurrent themes identified workplace supervision organisation role structures continuing professional growth relationships delivering patient focused care education connection resources utilising information technology communication panel based management quality improvement efforts rarely discussed interviews results indicate endorsement implementation care teams general mental health settings strengthened associated efforts targeted enhancing experiences aligned emergent themes
potent adhesion growth regulatory effectors characteristic expression profiles understanding molecular basis gene regulation case requires detailed information copy number genes sequence promoter report reveals plasticity respect species describe occurrence two gene human define current extent promoter sequence divergence interestingly cross species genome analyses also detected single copy display regulatory potential different expression profiles respective species pairs coding chromosomal vicinity found confined one gene whereas copy number variation also applied example rat presence multiple bands southern blotting despite single copy gene attributable two documented copy number variability thus taken consideration studying regulation genes species comparison species
aims investigate hypothesis presence transient morning muscle pain young healthy sleep associated sex related differences sleep eeg activity methods data morning muscle pain sleep variables obtained visual analog scales second night recordings nineteen normal control subjects age sex matched tooth differences sleep stage distribution duration number sleep stage shifts number rhythmic muscle activity events hour eeg activity analyzed blind subject status influence pain gender subjects assessed fishers exact test mann whitney test two sample test analysis variance anova results low intensity morning transient pain reported sex difference event frequency higher subjects hour hour fewer sleep stage shifts irrespective sex pain status female significantly lower theta alpha eeg activity compared female subjects irrespective pain conclusion female lower theta alpha eeg activity irrespective transient morning pain
generating dimensional ghz state basis measuring basis dynamic quantum secret sharing scheme proposed proposed scheme multiple participants added one update period shared secret need changed participants added need online compared existing schemes proposed scheme efficient practical
paper argue flexible algorithm frameworks useful capture wide variety algorithmic components heuristic algorithms serve basic experimental frameworks one utilities implement wide variety different algorithm components alternative choices single stochastic local search methods currently extending existing frameworks direction exemplify approach considering example simulated annealing fact wide variety design choices algorithms proposed literature algorithm frameworks simply collect potentially available choices provide tool experimental analysis specific algorithms component choices iii allow generation new algorithm variants combining components new ways show limited computational experiments show benefit tuning context way conclusions performance algorithms altered way
although high rates serum testosterone deficiency reported men spinal cord injury sci determinants attributes yet established aim study recognize among putative determinants attributes androgen deficiency significantly associated low testosterone adjustment confounders men chronic sci biochemical androgen deficiency total testosterone exhibited patients significant correlates testosterone levels follows weekly leisure time physical activity explored questionnaire people sci body mass index bmi homeostatic model assessment insulin resistance triglycerides sexual symptoms explored aging males symptom questionnaire multiple linear regression analysis among putative determinants low testosterone weekly bmi exhibited significant association testosterone levels explaining testosterone variability respectively linear regression models among various putative attributes androgen deficiency lower sexual desire lesser extent higher exhibited significant associations lower testosterone levels adjustment bmi age comorbidities weekly conclusion poor high bmi low sexual desire independent predictors low testosterone men chronic sci relevant clinical practice features routinely assessed rehabilitation settings sci poor high bmi modifiable life style related risk factors prospective studies clarify whether life style modification increase level testosterone improve low sexual desire relevant clinical attribute low testosterone men sci
article presents novel hybrid optimization approach nonlinear controller distribution static compensator connected distribution system distributed generation units nonlinear control based partial feedback linearization two proportional integral derivative pid controllers regulate voltage track output control system conventional scheme trial error method used determine pid controller coefficients article uses combination fuzzy system simulated annealing intelligent water drops algorithms optimize parameters controllers obtained results reveal response optimized controlled system effectively improved finding high quality solution results confirm using tuning method based fuzzy significantly decrease settling rising times maximum overshoot steady state error voltage step response proposed hybrid tuning method partial feedback controller achieved better regulation direct current voltage capacitor within furthermore event fault proposed controller tuned fuzzy method showed better performance conventional controller controller without optimization fuzzy method regard fault duration times
replication human papillomavirus hpv double stranded dna genome accomplished two viral proteins host dna replication factors hpv dna replication established model eukaryotic dna replication potential target antiviral therapy assays measure transient replication hpv dna transfected cells developed rely plasmid carrying viral origin dna replication together expression vectors replication plasmid typically measured southern blotting pcr analysis newly replicated dna digested dna several days post transfection although extremely valuable assays difficult perform high throughput quantitative manner describe modified version transient dna replication assay limitations incorporating luciferase expression cassette cis replication plasmid results increased levels luciferase activity accurately quantified normalized luciferase expressed control plasmid thus need dna extraction digestion analysis provide detailed protocol performing hpv type dna replication assay plate format suitable small molecule screening quantitative high throughput nature assay greatly facilitate study hpv dna replication identification inhibitors thereof
work addresses model predictive controller design complex solar thermal storage system models real landing solar commercial community overall discrete system obtained coupled finite infinite dimensional subsystems solar collector heat exchanger hot tank gas without spatial approximation model reduction novel model predictive control addresses house heat regulation constrained optimization problem manipulation constraints accounts possible unstable system dynamics disturbances arising solar realistic output regulation considered inclusion observer constructs finite infinite dimensional states proposed model development control regulation successfully account long range variability environmental economic conditions associated overall operational costs large scale solar energy community finally controller performance assessed numerical simulations elsevier ltd rights reserved
process tension control material testing using flexible circuit board testing machine featured multi variable nonlinearity time delays time variation order ensure tension precision stability servo motor speed reliability test results paper establishes accurate system model novel three dimensional adaptive fuzzy pid controller designed specially simulation results show proposed adaptive fuzzy control method robust external disturbance also excellent dynamic steady state characteristics traditional ones
qualities color images captured digital imaging devices vulnerable scene illumination settings given environment colors captured objects accurately reproduced illumination settings known priori undesirable property inevitably degrade qualities captured images lead difficulties subsequent image processing stages considering task controlling scene illumination color correction emerged plausible post processing procedure efficiently restore scene given image study new color correction technique called saturation avoidance color correction algorithm proposed remove undesirable effect scene unlike established color correction algorithms proposed comprises nonlinear pixel adjustment mechanism avoid saturation effect color manipulation process collection color images including indoor outdoor underwater images used verify capability extensive experimental studies reveal proposed algorithm preferable existing techniques former high capability mitigate color saturation issue able produce corrected images visualization
traditional protein conjugate nicotine vaccines shown less desired immunological efficacy due poor recognition internalization immune cells developed novel lipid polymeric hybrid nanoparticle based nicotine vaccine enhance immunogenicity conjugate vaccine studied influence particle size immunogenicity pharmacokinetic efficacy results demonstrated regardless size induce significantly stronger immune response nicotine compared conjugate vaccine particularly significantly higher anti nicotine antibody achieved compared addition reduced distribution nicotine brain significantly exhibited better pharmacokinetic efficacy presence adjuvant results suggest lipid polymeric nanoparticle based nicotine vaccine promising candidate treat nicotine dependence elsevier inc rights reserved
melatonin glands secretory product implicated pathophysiology migraine melatonin critical functions human physiology research underscores importance melatonin circadian rhythm sleep mood regulation clinical observations indicated migraine attacks seasonal menstrual circadian timing suggesting mechanisms alterations involve etiology disease however topic received relatively little attention migraine literature associations melatonin circadian preference sleep mood states investigated current study fifty five patients females males compared gender age matched control subjects females males socio questionnaire beck depression inventory beck anxiety inventory pittsburgh sleep quality index profile mood states questionnaire administered volunteers blood samples taken participants room melatonin secretion blood melatonin levels measured using quantitative elisa test comparison controls melatonin levels significantly lower among migraine patients reported significantly greater scores confusion subscale total sleep latency subscale migraine patients nausea migraine attacks reported relevant certain food consumption significantly lower levels melatonin groups reveal statistically substantial difference circadian preferences
autonomous unmanned aerial vehicles often carry video cameras part payload outdoor video captured cameras used estimate attitude altitude uav detecting location horizon video frames paper presents video frame processing algorithm estimating pitch roll uav altitude frames obtained downward pointing video camera equipped lens open loop estimates serve redundant data used implement degradation event main closed loop control sensors fail fault tolerance purposes augment inertial sensors increased accuracy estimated values mean error angular degrees roll angular degrees pitch altitude estimation video mean error meters results presented compared actual attitude altitude values obtained traditional inertial measurement unit case altitude comparison absolute air pressure sensor algorithm developed personal computer work frames per second uses simple image processing functions deployed using open source libraries lightweight computing boards capable image processing
construction project management increase project cost due resource fluctuation widespread paper proposed new resource control indicators reflecting resources resources according disadvantages traditional control indicators resource project network planning considering substantial increased costs due resources fluctuation based classification extra costs study found relationship resource imbalance extra costs analyzed resources resources cost variation caused resource imbalance thus control indicators resources resources reflecting resource proposed addition based case study feasibility control indicators proposed paper resource project network planning validated information valuable practical application resource optimization engineering project management
background evidence systemic treatments severe childhood eczema limited largely based extrapolation data adult studies current therapies often associated short long term side effects increasing vitro murine model evidence role ige atopic eczema aim study assess whether anti ige treatment improves eczema compared placebo methods design atopic dermatitis anti ige paediatric trial adapt randomised double blind placebo controlled study assessing role anti ige management severe paediatric eczema children severe atopic eczema objective scoring atopic dermatitis score recruited children candidates systemic therapy failed systemic therapy experienced side effects systemic therapy sixty two patients aged years receive anti ige months primary outcome measure validated eczema score objective weeks study power detect relative reduction active placebo groups significance discussion ige role play eczema particularly childhood forms basis hypothesis anti ige effective treatment patient population largest study evaluate efficacy anti ige versus placebo children severe eczema findings help clarify role anti ige potential treatment option patients severe childhood eczema
paper hybrid population based metaheuristic search algorithm named gravitational search algorithm combined particle swarm optimization pso pso proposed optimal designs two commonly used analog circuits namely complementary metal oxide semiconductor cmos differential amplifier circuit current mirror load cmos two stage operational amplifier circuit pso simple population based robust evolutionary algorithms problem individually proposed pso based approach overcome disadvantage faced pso algorithms employed paper optimal designs two amplifier circuits transistors sizes optimized using pso order minimize areas occupied circuits improve design performance parameters circuits various design specifications performance parameters optimized optimize transistors sizes design parameters using pso using optimal transistor sizes simulation program integrated circuit emphasis simulation carried order show performance parameters simulation results justify superiority pso differential evolution search artificial colony pso terms convergence speed design specifications performance parameters optimal design analog cmos amplifier circuits shown pso based design technique amplifier circuit yields least mos area designed circuit shown best performance parameters like gain power dissipation etc compared recently reported literature still difficulties challenges faced work proper tuning control parameters algorithms pso conflicting design performance parameters design specifications partially overcome repeated manual tuning multiobjective optimization proper alternative way overcome difficulties
paper discuss development ambient intelligent based system monitoring dementia patients living homes within system groups wireless sensor devices deployed specific locations within patients home accessed via standardized interfaces provided open middleware platform sensor group intelligent agents used learn fuzzy rules model patients habitual behaviours environment online rule adaptation technique applied facilitate short term tuning behaviours long term tracking behaviour changes due effects cognitive decline caused dementia proposed system reports macro level behaviour changes micro level perception drift care providers enable make better informed assessments patients cognitive abilities changing care needs demonstrate experiments real pervasive computing environment intelligent agent approach learn model users behaviours allow online adaptation model better approximate behaviours identify long term macro level behaviour changes attributed cognitive decline also show example users perceptions thermal comfort captured provide means micro level perception changes monitored
erectile dysfunction low testosterone levels common men type diabetes investigated impact testosterone quality life qol diabetic men men identified within study cohort men subjects completed health androgen deficiency aging male questionnaires total testosterone sex hormone binding globulin levels study participants measured free testosterone levels calculated subgroup patients completed international index erectile function questionnaire linear regression analyses corrected age body mass index bmi smoking alcohol consumption cardiovascular disease cvd total scores significantly positively correlated levels levels levels among men trends strengthened adjusting age bmi smoking alcohol consumption cvd scores significantly correlated inversely levels positive linear relationship observed scores total score patients reported average score less without lower testosterone greater severity independently correlated poorer physical function social function vitality decline general health domains first study report testosterone deficiency severity independently associated reduced qol men furthermore low testosterone markers poor health impact individuals self perception health status
paper proposes novel compressive sensing based perceptual algorithm visual tracking tracking object represented dimensionality reduced feature projected perceptual feature sparse measurement matrix besides updating weight map assigned object weight map updated according accumulation block distance block center weight map based object representation weight map tracker searches local region maximum similarity coarse fine way addition introduce visual attention knowledge object namely always located center weight map handle model drift problem extensive experiments demonstrate proposed tracking method outperforms state art methods challenging scenarios tracker especially insensitive location initial box elsevier rights reserved
aim publication brief safe cost effective security solution cost time estimation tool small medium size enterprises since either budget cyber security general evaluation tool used determine approximate time costs small company face implementing comprehensive security solution analyzing iso iec standards additional security guidelines several recommendations necessary creates security implementation evaluation tool resulting product tool allows member enterprise carry small test determine necessary resources time security implementation
examine pattern solutions generalized logistic map includes spatial kernels growth competition terms show map includes particular case fisher equation demonstrate existence three kinds stationary nonlinear solutions one uniform one cosine type refer solution another form gaussian also obtain analytical expressions describe nonlinear pattern behavior system establish stability criterion define thermodynamics quantities entropy order parameter based pattern pattern pattern pattern transitions properly analyzed show pattern solutions related recently observed peak adding phenomenon nonlinear optics elsevier rights reserved
unknown adverse effects antipsychotics consequences compromise therapeutic adherence serious present consensus recommendations made group experts regarding management current consensus developed phases review scientific literature subsequent round table discussion attempt reach consensus among experts review authors final conclusions reaching complete consensus include recommendations appropriate time act detection discuss evidence available options decreasing dose antipsychotic drug switching antipsychotics adding adding dopaminergic agonists type treatment consensus also included recommendations specific populations patients first psychotic episode pediatric youth population bipolar disorder personality disorders elderly population elsevier inc rights reserved
purpose aim study evaluate effects containing rome italy quality life qol sexual function women methods sixty women symptoms system longer days fsh enrolled modified index used evaluate menopause symptoms short form female sexual function index female sexual distress scale used assess qol sexual function sexual distress respectively study two follow ups months results women reported improvement total score baseline follow ups follow women reported qol improvements functions follow reported improvements categories baseline total score score indicating sexual dysfunction sexual distress total scores change follow contrary follow score score dropped conclusion effective modulating symptoms women progressive reduction symptoms reported women usage contribute improve qol sexual life
present study aimed examine difference self control strength individuals without antisocial personality disorder aspd chinese male sample thirty seven male met criteria dsm aspd asked four minute silent interview ignore words displayed screen strength task conducted watching participants time dependent variable result showed significant interaction group aspd aspd group time baseline post manipulation measure post manipulation result significantly worse baseline result aspd group aspd group results indicate tasks contribute depletion lead deficit self control strength aspd
background despite improvements child survival past four decades estimated million children age five die year deaths occur neonatal period interventions reduce neonatal mortality needed mother care one life saving intervention however yet fully integrated health systems around world utilizing conceptual framework integration targeted health interventions health systems hypothesize caregivers play critical role adoption diffusion assimilation objective research identify barriers implementation scale caregivers perspective methods searched pubmed embase web science scopus regional databases using search terms mother care care skin skin care studies published january august included eligible published work based primary data collection regarding barriers implementation family perspective abstracted data linked conceptual framework using approach themes identified within five framework areas using software results identified total abstracts removing studies included analysis majority publications published within past years sample size less recruited participants health facilities approximately one third studies conducted conducted africa identified four themes surrounding interaction families intervention bonding benefits mothers infants perceptions bonding mother infant social support assistance people perform sufficient time perform medical concerns mother newborn health furthermore identified barriers adoption caregivers within context health system regarding service delivery embedded within broad social context barriers adoption caregivers included adherence traditional newborn practices stigma surrounding preterm infant gender roles regarding conclusion efforts scale integrate health systems reduce barriers order promote uptake intervention caregivers
non pathogenic gram positive soil bacterium vitamin analogs amino compounds antibiotics notably number analogs currently investigation regard development novel first step towards understanding metabolism analogs humans key enzymes studied human efficiently converted amino respectively human accepted substrate consequently adenine synthesized latter enzyme amino adenine cofactor analogs different physicochemical properties compared thus cofactor analogs potential render inactive negatively affect human metabolism found inhibit human summary suggest lower toxic potential better suited lead structure develop antimicrobial compounds elsevier inc rights reserved
importance dominance relationship analysis recognized decision making applications paper propose problem finding customer preferences cost constraints utilizes concept dominance business analysis perspective problem aims discover dominance relationship products potential customers given set customer preferences want help company design set competitive products products satisfy many customer requirements possible cost producing products within specified threshold competitive products mean products dominated products market formally define problem discuss difficulty problem also present foundation pruning methods proposed three efficient algorithms utilize pruning methods address problem addition also prove correctness proposed algorithms
overcome drawbacks plasma stealth technology real life application practical multilayer stealth structure composed plasma radar absorbing material ram presented paper based technique referred transmission line analogy method reflection coefficients polarized wave parallel polarized wave polarized wave incident upon multilayer structure determined respectively effects incident angle kinds parameters plasma including electron density collision frequency thickness effectiveness composite stealth structure studied systematically numerical results indicate proper design power reflected wave significantly reduced wide frequency bandwidth provides useful references plasma stealth technology applied
disease chronic disease elderly assuming life expectancy increase considerably coming decades disease gain medical socioeconomic relevance addition known familial genetic causes environmental factors nicotine diabetes alcohol trauma work discussed knowledge factors influence onset severity disease important diagnosis therapy prevention disease
large group small mediate secretory membrane transport biogenesis essential components vesicle trafficking machinery specific protein together effectors coordinates dynamics trafficking pathway determines proteins destination functional impairments proteins mutations post translational modifications disrupting regulatory network vesicle trafficking implicated tumorigenesis therefore vesicle transport regulators play essential roles mediation cancer cell biology including uncontrolled cell growth invasion metastasis context dependent role act either tumor suppressor different cancers found discrepancies due part interaction specific protein different effectors various tumors review recent advances roles communicating effectors tumor progression review also emphasize dysregulation mediated membrane delivery shifting normal cell behaviors toward malignancy thus recovery dysregulated vesicle trafficking systems cancer cells provide future directions potential strategy tumor progression
gained considerable attention effectiveness rapid contextual training professional development programs however quality teaching demonstration peer feedback influence individuals attribution self correction leading ineffective learning study workshop professional development program elementary school science teachers investigated results showed effectiveness negatively affected participants perception bias due social categorization moreover indicated participants perception group group classified degree individuals science knowledge social categorization participants tended experience perception conflicts caused inability see personal faults typical perception bias seeing ones strengths seeing others shortcomings frequently recognized group results converge highlight importance social categorization perception bias relevant
qualitatively analyzing responses letter writing media literacy education program study examines sixth understandings producers responsibility creating media content responses suggest understandings producers responsibility bounded within context media use consumers rather citizens findings focus importance introducing contextual factors media production challenges researchers educators face
article evaluates relationship family state central study american political development compares parallel efforts feminist political legal put table issues public private distinction family assumptions role family womens maternal labor political order within family illustrates legal scholars regularly examine evolution time family definitions forms gender roles also evolution various forms state regulated supported family article suggests study american political development big within scholars diverse disciplines benefit conversations parallel indicate importance contextual temporal examination family state article analyzes recent court opinion held sex couples exercise fundamental right many every state
background diagnostic evaluation patients diffuse lung disease best achieved multidisciplinary team correlating clinical radiological pathologic features surgical lung biopsy remains gold standard diagnosis idiopathic interstitial emerging data suggest increasing role evaluation describe experience patients methods retrospectively reviewed medical records patients radiographic features underwent clinic june september results seventy four patients women mean age years included mean maximal diameter samples range number samples per procedure three range one seven diagnostic yield specimens frequent patterns inflammation patients organizing pneumonia patients resulting final diagnoses hypersensitivity six patients six patients connective tissue disease associated three patients drug toxicity three patients infection related two patients two patients aspiration one patient patterns included respiratory three patients acute organizing pneumonia two patients interstitial pneumonia patient diffuse alveolar damage one patient pulmonary alveolar one patient one patient eosinophilic pneumonia one patient vasculitis one patient food particles one patient malignancy three patients developed one patient bleeding occurred patients conclusions single center cohort demonstrated diagnostic yield rates bleeding respectively optimal use needs determined
higher plants participate biosynthesis many important secondary metabolites reported first time isolation new cytochrome cdna expressed stem specific manner designated native medicinal plant species china using race pcr full length cdna long containing open reading frame orf encoding polypeptide amino acids bioinformatic analysis revealed contained heme binding domain showed homology plant cytochrome southern blotting analysis revealed one copy present genome northern blotting analysis revealed expressed tissue specific manner highly stem root leaf flower study suggests likely involved pathway
aim study assess percentage users frequency use number cosmetic products consumed home french population evaluation performed adult child baby consumers pregnant women also taken account work products cosmetics including general hygiene skin care hair care hair make solar products studied strengths study separation data sex age groups consideration priori risk subpopulations consideration large number cosmetic products current consumption data useful safety safety agencies order protect general population risk subpopulations elsevier ltd rights reserved
use planning management tools water management urban environments promising area paper focuses description two indicators water intensity purchase potential water self rainwater harvesting expanding sector retail measures water consumed per average customer purchase whereas quantifies potential capacity system satisfy water demand rainwater tools checked two case studies spain brazil results show respectively measures efficiency water use water demand mainly low quality met potable water supply network stormwater runoff lost sewage results spain brazil indicate satisfy needs rainwater even water combined use useful planning design evaluation monitoring
study association heavy metals water sampled river frequently exposed pollutant sources sugar production factory solid wastes area explored oxidative effects heavy metals evaluated analyzing liver enzymes namely superoxide dismutase sod catalase cat malondialdehyde mda cortisol heavy metal concentrations fish water collected three different locations along river summer winter determined coupled plasma atomic emission spectroscopy aes water fish liver heavy metal concentrations exhibited increasing trends upstream downstream water liver samples collected summer higher heavy metal concentrations obtained winter mean heavy metal concentrations increased liver heavy metal concentrations higher water exhibited almost increasing trend positive relationships liver water heavy metal concentrations especially cadmium lead obtained among liver enzymes mda followed increasing trend obtained heavy metals hand cat sod contrary spatial pattern change heavy metals mda although values heavy metals mda two locations fish locality significantly higher values cortisol indication stress causing factors fish
stress plays key role addiction etiology relapse rodent models following repeated periods alcohol drug compensatory changes occur central nervous system cns circuits involved behavioral emotional response stressors examine predicted manifestation recently alcohol dependent humans participants completed translational laboratory task uses unpredictable predictable stressors implicated putative cns mechanisms mediate alcohol dependent participants displayed significantly greater unpredictable predictable stressors relative controls size effect problems degree withdrawal syndrome supports rodent model thesis sensitized stress response however effect also represent risk mark severe comorbid psychopathology regardless pharmacotherapy psychological interventions target unpredictable stressor response reduce stress induced relapse
corrosion inhibition efficiency performance mild steel solution evaluated using weight loss polarization electrochemical impedance spectroscopy eis techniques inhibition efficiency inhibitors increased increase concentration thermodynamic parameters delta ads activation parameters delta degrees delta degrees calculated investigate mechanism inhibition polarization studies revealed studied inhibitors mixed type scanning electron microscope sem energy dispersive ray spectroscopic atomic force microscopy studies used characterize surface morphology inhibited mild steel elsevier rights reserved
plastic surgeons application medicine surgery almost decades ago initially used treat cervical vaginal pathologies ever since energy based devices deployed treat pelvic pathologies improve fertility recent technological developments triggered unprecedented wave publications assessing efficacy fractional laser vaginal wall reversing natural aging processes studies shown certain degree thermal energy deposited vaginal wall stimulates proliferation glycogen enriched epithelium collagen formation lamina improves natural control review aimed review data guide future research unique assembly experts around globe compiled manuscript based thorough literature review personal experience wiley periodicals inc
using elastic objects scheme passive control efficiently control high frequency vibration however generally control low frequency vibration especially vibration control using smart material actuators utilized structural vibration control ability deliver large forces wide band responses precise relatively large displacement giant actuator great potentials vibration especially low frequency vibration control research giant actuator low frequency adaptive vibration control realized investigated order avoid frequency effect realize control using linear harmonic signal permanent biased giant actuator designed constructed adaptive control algorithm control system realized self tuning adaptive control method vibration control proposed comparison inverse feedforward pid control fit step response previous work research actuator low frequency adaptive vibration control finally experimentally verified proves giant actuators secure applications adaptive control low frequency vibration
introduction irritable bowel syndrome ibs prevalent functional gastrointestinal disorder represents major cost healthcare services ibs patients represent one third ibs population currently treated bile acid antidepressants also available usa japan korea thailand label treatment areas covered article focuses novel pharmacological agent recently approved fda treatment patients ibs expert commentary efficacy safety treating bowel habit alterations pain short long term make drug addition therapeutic alternatives ibs positioning ibs algorithm depend real world prevalence small risk mild
anorexia nervosa body disorder exhibit distorted perception negative evaluations appearance however little known perceive others appearance whether conditions share perceptual distortions participants now weight restored healthy comparison participants rated photographs others faces bodies attractiveness overweight much photographs triggered thoughts appearance compared responses among groups stimulus type level detail spatial frequency hcs lower attractiveness ratings others bodies faces high detail low detail images rated bodies overweight triggered think appearance faces bodies symptom severity associated greater triggering thoughts appearance higher endorsement overweight ratings bodies symptom severity associated greater triggering thoughts appearance bodies higher overweight ratings low detail images triggered think facial appearance show similar behavioral phenotypes negative appearance evaluations others faces bodies thoughts appearance triggered even images outside primary appearance concerns suggesting complex cross disorder body image phenotype previously assumed future treatment strategies benefit addressing individuals evaluate others addition wiley periodicals inc int eat
paper method discrete element model simulation used investigate mechanical properties sic ceramic materials action pre stress using bonded particle model several different numerical tests tests sic ceramic established different pre stress values applied lateral surface ceramic specimen numerical simulation process tests carried least times different random number average mechanical properties results calculated showed existence pre stress significant effect mechanical properties materials enhance strength materials force action material machining process force action force cracks initiation propagation limited
three spectral methods namely mapped used order solve challenging systems boundary layer problems third second orders last two methods enable fourier type analysis mainly fast polynomial transformations used order improve process optimization scaling parameters generally second method mentioned produces best results unfortunately remain sub geometric respect accuracy however methods avoid domain rather arbitrary techniques challenging problems fluid mechanics including non newtonian fluids accurately solved
method increasing radiation hardness bipolar operational amplifiers effects presented method based use improved current mirror modified input stage circuit
human infants involved communicative interactions others start understand language generally thought communication useful establishing interpersonal relations supporting joint activities absence symbolic functions language provides early communicative contexts allow infants learn world however recent studies suggest someone demonstrates something using object medium instruction infants object whole class objects kind thus object just like word play role symbol stands something infants learn general knowledge kind object nonverbal communication single item kind symbolic capacity one roots development symbolic understanding children
compounds contain chemically stable carbon phosphorus bond widely distributed amongst primitive life forms including many marine constitute significant component dissolved organic phosphorus reservoir virtually compounds synthesized pathway key step rearrangement however bond cleavage microorganisms catalyzed number enzymes others yet mechanism expression pathways catabolism controlled ambient levels inorganic others independent report review enzymology bond metabolism bacteria also present results silico investigation distribution genes encode pathways responsible bacterial genomes marine libraries likely modes regulation currently available whole genome bacterial sequences indicates contain genes encoding putative pathways biosynthesis similar encode one pathways catabolism analysis data global ocean survey suggests respectively bacterial genomes across sites sampled encode pathways routes involving hydrolase sequence predominant likely substrate inducible mechanisms involved regulation data present indicate likely importance global cycling extension role marine productivity carbon nitrogen dynamics
various mutations gene encodes protein significantly associated onset autosomal recessive juvenile parkinson neuronal cells multi domain protein terminal part contains terminal part consists four zinc coordinating domains viz ring disease mutations spread domains although mutations regions affect functionality adversely mutations domain seen neuroprotective activity current work carried detailed silico analysis study extent pathogenicity mutations spanning domain region mutation snps mutant study structural functional implications mutations domain studied solvent accessibility intra molecular hydrogen bonding profile domain analysis various computational tools finally analysed interaction energy profiles mutants compared wild type protein using discovery comparing various analyses safely concluded except mutations mutations potentially deleterious affecting various structural aspects domain architecture study based purely computational approach potential identify disease mutations information used treatment diseases prognosis elsevier rights reserved
similarity join xml documents usually modeled rooted ordered labeled trees widely applied due ambiguity references real world objects conventional method dealing issue based tree distance shortage flexibility efficiency paper propose two novel operations together extended tree distance achieve good performance similarity matching hierarchical data structures run time worst case propose generation set distance good approximation tree distance improve join efficiency time complexity experiments real synthetic databases demonstrate benefit method efficiency scalability
etiological mechanism underpinning sports related injury complex multifactorial frequently athletes perceive excessive training principal factor injury observation biologically plausible yet somewhat ambiguous applied training load increased increase risk sports injury development irrespective absolute amount training indeed little rigorous scientific evidence exists support hypothesis fluctuations training load compared absolute training load important explaining sports injury development one reason prospective data scientific studies analyzed different manner time event analysis useful statistical tool analyze influence changing exposures injury risk however potential time event analysis remains exploited sports injury research therefore purpose present article present discuss measures association used time event analyses present advanced concept time varying exposures outcomes paper different measures association cumulative relative risk cumulative risk difference classical hazard rate ratio presented manner suggestions interpretation study results provided summarize time event analysis statistical sports injury prevention researchers enables analyze complex highly dynamic reality injury etiology injury recurrence time recovery across range sporting contexts
array pharmacological environmental factors influence development maintenance tobacco addiction nature influences likely changes across course extended smoking history time drug seeking become uncontrolled present study used animal model examine factors drive nicotine seeking behavior either brief extended self administration training experiment extended training increased rats sensitivity nicotine indicated shift dose response curve motivation work nicotine indicated increase break point achieved progressive ratio schedule experiment extended training nicotine paired cue capacity maintain responding high level nicotine however experiment showed mechanisms involved responding nicotine nicotine paired cue treatment partial nicotine receptor agonist suppressed responding nicotine potentiated responding nicotine paired cue hence across extended nicotine self administration pharmacological environmental influences nicotine seeking increase nicotine seeking controlled multiple sources therefore highly resistant change
background serious immune disorder epstein barr virus ebv common trigger secondary cell receptor tcr gene rearrangement detectable half patients ebv associated using southern blotting conventional polymerase chain reaction pcr analyses however clinical significance unclear impact tcr gene outcome patients ebv evaluated using sensitive methods study used multiplex pcr analysis evaluate tcr gene rearrangement childhood ebv methods six children ebv enrolled study ebv load blood quantified real time pcr tcr gene rearrangement analyzed multiplex pcr results patients showed monoclonal peaks tcr beta tcr gamma diagnosis serial monitoring one patient disclosed change rearrangement pattern tcr genes response conclusion findings suggest multiplex pcr highly sensitive method detecting cell useful predicting therapeutic response childhood ebv elsevier rights reserved
objective purpose study present case report review relevant literature induced dermatitis injury child abuse case month old girl presented partial thickness burn suspected caused child abuse investigation parents administering large doses child chronic constipation discussion child abuse burning characteristic physical examination findings differ pattern induced dermatitis reported literature appear risk factor induced dermatitis surprisingly dose correlate severity burn injury physicians aware possibility induced dermatitis mimicking burn injury parents educated risk administering counter children
purpose use social media particular community question answering websites learners increased significantly recent years vast amounts data sites provide opportunity investigate topics discussion receiving attention purpose paper automatically analyse content popular computer programming website determine exact topics narrow categories help determine subject difficulties learners authors able rank identified topics categories according frequencies therefore mark asked subjects hence identify difficult challenging topics commonly faced learners computer programming software development design methodology approach work authors adopted heuristic research approach combined text mining approach investigate topics categories website almost analysed categories refined using classification system identifying counting occurrence frequency topics categories semantic relationships established data presented rich graph visualized using graph visualization software findings reported results corresponding discussion given indication insight gained process refined potentially used instructors teachers educators pay attention focus commonly occurring topics subjects designing course material delivery teaching methods research limitations implications proposed approach limits scope analysis subset contain one links therefore developing sophisticated text mining methods capable analysing larger portion available data improve accuracy generalizability results originality value application text mining data analytics technologies education created new interdisciplinary field research education information sciences called educational data mining work presented paper falls field research early attempt investigating practical applications text mining technologies area computer science education
background considering limited cross protection offered current hpv vaccines understanding hpv genotype distribution among different population essential predicting efficacy current vaccine new vaccine strategy present work aimed investigating hpv genotypes distribution among women without cervical carcinoma eastern india methods total participants enrolled january june pcr sequencing nested multiplex type specific pcr performed hpv detection genotyping distribution cases includes invasive cervical carcinoma icc inflammatory normal statistical analyses performed using spss version software medical version value parity low socio economic condition rural residential area post menopause state significantly associated hpv infection multiple infections significant association clinicopathological variables stage metastasis cell type except tumor size icc cases impact vaccines preventing cervical cancer respectively conclusion data help planning appropriate strategy disease monitoring provides baseline data post vaccination surveillance region vaccine significant preventing cervical carcinoma hence effective vaccination program based regional hpv epidemiological profile along cervical cancer screening necessary reduce cervical cancer burden india
immune system plays crucial role progression alzheimers disease recently immune dependent cascade induced systemic immune activation verified play beneficial role mouse models tested whether bacillus immunization alters pathology cognitive dysfunction app mouse model beta vaccination positive control found treatment reversed cognitive decline extent observed beta reduce beta burden brain demonstrated enhanced recruitment inflammation resolving monocytes across spaces cerebral sites plaque pathology app mice furthermore elevated regulatory cell levels control app mice regulated back wild type levels treatment beta vaccination addition treatment induced production circulating interferon ifn gamma controls beta vaccination though similar reductions brain levels pro inflammatory cytokines observed beta compared controls great effect cerebral anti inflammatory cytokine levels expression neurotrophic factors brain app psi mice thus suggested exerts beneficial immunomodulatory effect app mice mitigation systemic immune suppression induction ifn response response elsevier inc rights reserved
background aim analyzed whether insulin resistance assessed homeostasis model assessment index hepatocellular carcinoma hcc risk patients chronic hepatitis virus hbv infection methods retrospective cohort chronic hbv infected patients age men underwent detailed health program including peptide fasting blood glucose measurement followed year analyzed results median follow range patients developed hcc hcc incidence rate higher patients higher value lower value significant factor associated hcc development multivariable adjusted model adjusted age sex cirrhosis hbv dna levels association hcc markedly attenuated became longer statistically significant adjusted obesity hypertension diabetes subgroup analysis value independent factor associated hcc patients without overt metabolic abnormalities hypertension diabetes metabolic syndrome overt metabolic abnormalities conclusion insulin resistance assessed associated risk hcc indicating useful tool risk hcc chronic hbv infected patients particularly patients without overt metabolic abnormalities
aim evaluate quality accuracy websites written public inflammatory bowel disease ibd crohns disease ulcerative colitis assess level methods google search engines searched independently three researchers december english language websites selected basis predetermined inclusion exclusion criteria researchers independently evaluated quality website using instruments levels calculated using two formulas grade level index index agreement calculated using kappa coefficient results eighty four websites finally identified scores varied minimum score maximum mean median interquartile range interquartile range iqr minimum score maximum mean median iqr websites reviewed websites universities research centers foundations associations commercial pharmaceutical companies volunteer work non university educational bodies grade level score mean index score significant correlation found two scores overall agreement measured kappa coefficient range rated good conclusion scores websites varied levels websites public level study highlights areas need improvement development patient education online materials ibd
recent decades studies based questionnaires interviews concluded doctors become face significant barriers seeking help several reasons proposed primarily notion doctors work environment inappropriate help seeking behaviour article idea physician paradox medical examined text comparative approach historical illness narratives written doctors suffering one specific diagnosis namely opioid addiction complex set considerations guiding behaviour patients extent revealed article concludes identity transition necessary become patient doctors held back professional status every step assist needs take shape based awareness underlying principles medical written illness narratives doctors highlighted article serve tool increase awareness
investigate suppression endogenous testosterone week strength training period influences activity satellite cells two moderately trained young men participated randomized placebo controlled double blinded intervention study participants randomized treatment analogue suppresses testosterone placebo strength training period started treatment included exercises major muscles biopsies obtained mid portion muscle resting level times lower compared placebo training induced increase level testosterone abolished training increased satellite cells number type fibres placebo whereas number significantly increased type fibres placebo remained unchanged changes satellite cells seen type fibres either group data microarray analysis indicated low testosterone affects bone proteins signalling regulate proliferation differentiation satellite cells weeks strength training enhances number type fibres largely blocked suppression testosterone data indicate low testosterone levels reduce differentiation satellite cells via bone proteins signalling pathway resulting reduced increases lean leg mass
paper proposes new relaxation based circuit simulation algorithm called backward waveform relaxation employs brand new strategy simulate simulates performing depth first search signal flow graph simulated circuits major advantage ability flexibly schedule calculating according converging situations enables act robustly efficiently dealing various types circuits simulation demand sod function also constructed proposed methods implemented tested simulating various circuits
learners second language increasingly interacting small groups part communicative methodological paradigm studies investigated social dynamics occur groups aim study introduce group work dynamic measuring instrument investigate relationship group work dynamic social climate existing within group learners state level motivational responses amount language produced interactive tasks context classroom based study speaking skills course consisting small group korean english learners intermediate high intermediate level enrolled korean university program data based different tasks part course two work groups task total groups instruments data collection consisted audio video recordings transcription verbal nonverbal language produced tasks measurement instrument post task motivation questionnaires results correlational analysis showed significant relationship task motivation language production nonverbal related behaviors furthermore found particularly influential shaping significantly associated learners task motivation especially form greater task enjoyment sense success studys findings therefore add support socio contextual perspectives motivation applied emphasize critical role social group factors motivation language development imply need educators focus creating positive group dynamics classrooms
installed capacity solar photovoltaic small size wind turbine residential microgrid gains promising growth developed countries however uncertain characteristic volatility still one significant factors affect effective operation conducted design distributed renewable resources considering household requirement reliability energy utilization implicit behavior meteorological uncertainty managed stochastic time series weather data satisfy objectives planning hybrid renewable generation system installed residential customers load management strategies conducted improve energy utilization green building renewable power planning stage proposed simulation framework realizes optimal installed capacity residential renewable generation storage device achieve effective energy utilization future green building
background influenza virus infections associated wide spectrum disease however studies investigated detail epidemiological virological characteristics asymptomatic mild illness influenza virus infections methods community based study hong kong followed initially healthy individuals household contacts symptomatic persons laboratory confirmed influenza identify secondary infections information daily symptom diaries used classify infections symptomatic signs symptoms including fever degrees headache cough nose symptom asymptomatic none symptoms compared patterns influenza viral shedding groups results identified confirmed secondary cases influenza virus infection household setting including asymptomatic cases duration viral rna shedding shorter declined rapidly asymptomatic symptomatic cases mean levels influenza viral rna shedding asymptomatic cases approximately log copies lower symptomatic cases conclusions presence influenza viral shedding patients influenza symptoms reflects potential transmitting virus close contacts findings suggest research needed investigate contribution persons asymptomatic clinically mild influenza virus infections influenza virus transmission household institutional community settings
generating discriminative input features key requirement achieving highly accurate classifiers process generating features raw data known feature engineering take significant manual effort paper propose automated feature engineering derive suite additional features given set basic features aim improving classifier accuracy discriminative features assist data scientists automation implementation specific http computer network traffic measure effectiveness proposal compare performance supervised machine learning classifier built automated feature engineering versus one using human guided features classifier addresses problem computer network security namely detection http use process network traffic base features apply automated feature engineering calculate larger set derived features derived features calculated without favour base feature include entropy length string features counts time numeric features feature selection used find relevant subset features testing showed classifiers achieved detection rate false positive rate datasets conclude automated feature engineering provide advantages increasing classifier development speed reducing development technical difficulties removal manual feature engineering achieved also maintaining classification accuracy crown copyright published elsevier ltd rights reserved
daily dialogue leaders workers traditional construction sites primarily focused production quality time issues rarely involves occupational safety health issues leadership training program entitled toolbox training developed improve construction knowledge communication skills daily planning work tasks related risks construction sites program builds popular toolbox meeting concept however little research evaluating types meetings article describes development implementation feasibility toolbox training program results process evaluation outcome evaluation total companies participated training five successive groups following group program continuously evaluated revised final version fifth group evaluation utilized action research strategy mixed methods approach questionnaire interview observation data process evaluation results showed eight toolbox training topics relevant useful majority experienced positive changes daily work methods interactions colleagues leaders customers construction program unique contribution leadership training construction industry potentially applied adapted many sectors however still need testing long term effects program safety climate injuries business future studies authors published elsevier ltd
correlates bacterial poorly understood especially hiv infection cohort study hiv seropositive comparison women assessed every months considered present three four criteria met behavioral characteristics assessed using structured interviews multivariable logistic regression used generalized estimating equation models determine factors associated cumulative incidence time assessed using log rank test among women hiv hiv seropositive contributing visits diagnosed visits hiv women visits hiv seropositive women cumulative incidence hiv women seropositive women adjusted analyses factors associated younger age ethnicity lower income less education recruitment site recruitment cohort drinking current smoking depression sex male partner hormonal contraception menopause negatively associated women prevalent within year persistent found participants neither proportion differed hiv time trends proportion women single visit identified common among women risk hiv hiv infection predispose associated instead behavioral cultural factors
aim review give general view current status scientific basis role copper human health disease roles copper human metabolism coordination chemistry biological ligands involved multiple steps metal assimilation distribution copper bioavailability depends four main factors absorption copper gastrointestinal tract copper transport portal blood extraction copper hepatocytes portal blood supply copper uptake peripheral tissues central nervous system important copper pumps providing pathway copper ions man extensively discussed different theories putative role copper transport blood presented data interactions among trace elements copper level systems body also shown finally function different drugs non agents utilized clinical practice therapy disease treated particular discussed elsevier rights reserved
purpose review review seeks describe role receptor modulating non hdl lipoprotein levels platelet numbers atherosclerosis recent findings genetics studies revealed provides protection atherosclerosis potential interactions ldl receptor regulate rate ldl uptake result lower plasma non hdl cholesterol platelets induces expression hepatic platelet activity promotes plaque formation atherosclerosis summary multifunctional receptor clearance platelets impact levels plasma non hdl cholesterol makes potential therapeutic target treatment atherosclerosis
propose classical analog induced transparency cylindrical metallic walls transparency induced multi mode interactions narrow line width also consists single second order transverse mode corresponds function distributions investigated extensively due unique characteristics increasing thickness gold layers demonstrate frequency agile single mode transparency phenomenon radiation found center frequency transparency linearly related gold thickness indicating achievement controllable single mode device field distributions cross sections verify single second mode transparency indicate mechanism frequency manipulation significantly benefit mode control engineering applications elsevier rights reserved
urbanization brings economic social benefits also causes water pollution environmental ecological problems paper provides theoretical framework quantitatively analyze dynamic relationship water resource utilization process urbanization using data province first construct indices evaluate urbanization water resource utilization adopt entropy model examine correlation urbanization water resource utilization addition introduce dynamic coupling model analyze predict coupling degree urbanization water resource utilization analyses show pairing rising urbanization overall index water resource utilization province experienced decline rise decline trend specifically index water resource utilization reached lowest point gradually began rise water resource utilization reached highest value coupling degree urbanization water resource utilization relatively low varying degrees degrees rising since sample forecasts indicate coupling degree reach highest value degrees start gradually decline province chosen studied area one selected pilot provinces chinas economic reform social development analysis relationship water resource utilization urbanization essential understanding dynamic relationship two systems also serves important input developing national policies sustainable urbanization water resource management
increased market demand composite products shortage expert compelling composite industry explore ways acquire skills experts transfer eventually machines lack holistic methods literature capturing composite skills especially involving complex research aims develop informatics based method enabled consumer grade gaming technology machine learning capture manufacturing task knowledge skill intensive hand proposed human interaction theory implemented automatically extract key knowledge constituents strategies manipulation techniques motion mechanics problem solving hand collectively skills significance research potential facilitate cost effective transfer skills experts real time automated supervision hand automation tasks future authors published elsevier ltd open access article license
inception indian industry fiber proved superiority fibers particularly area packaging food grains terms functionality due considerable tensile strength low good dimensional stability obviously natural choice packaging one growing alternatives todays context emergence technical made natural fibers includes geotextile products geotechnical applications products relevant areas geotextile certainly considered potential replacing majority todays popular synthetic products severe threats environment thereby adversely affecting eco application fabrics different types sites even designing sector observed ability fabric assume appearance contour crucial significance fabric attempt made paper study effect relevant property parameters comparative analysis fabric synthetic woven nonwoven fabrics respect end use requirements
development solar energy conversion production fuels water splitting water purification systems become important traditional fossil energy herein investigated coupling effect photo system conventional photocatalytic reaction novel doped hybrid structure decomposition selected model reaction context degradation organic pollutants nanocomposites consisting nanoparticles shown facilitate separation photo induced electron hole pairs photocatalytic activity maximized result photo cycle iii doping presence generate additional hydroxyl radicals result visible light degradation remarkably enhanced compared reference best knowledge first time striking increase reported photo system applied present photocatalytic system significance presence hydroxyl radicals photo performance doped assessed fluorescence tests additional light reaction mechanism via spin trapping enabled situ electron resonance elsevier rights reserved
objective establish injury profile soccer players first division brazilian soccer team addition investigated association characteristics injuries players age position method forty eight players brazilian first division soccer team followed one season descriptive statistics used characterize injury profile spearmans tests used verify association number severity injuries players age chi square test used verify association type injury players position fishers exact test used verify association severity injuries players position results incidence injuries hours matches hours training injury severity days competition training lower limb common location injury injuries muscular overuse non recurrent non contact injuries players age correlated amount severity muscle tendon injuries minimal injuries days lost moderate days lost severe injuries days lost furthermore muscle tendon injuries joint ligament injuries conclusion injury profile brazilian players investigated study reflected regional differences soccer practices results confirm influence players age position soccer injuries profile
research examined group membership attribution mind individuals found mind attribution inversely related size group individual belonged experiment mind attribution affected group membership rather total number entities perceived experiment moreover mind attribution individual varied perception individual group member participants attributed mind individual appeared distinct distant group members individual perceived similar proximal cohesive group experiments effect occurred human targets driven perception target group member rather knowledge target group member experiment elsevier inc rights reserved
foreign real time operating systems widely used last years russia developed aircraft russian integrated modular research projects presently question substitution russian analogues article provides requirements operating system satisfy order used civil analysis existing foreign domestic aspects operating system development process published elsevier open access article license
measurement observation chaotic system states major challenge control engineering due lack availability states control purpose fails realize required performance paper new observer based structure proposed control chaos recently developed rise feedback controller combined adaptive neural observer control chaotic system unlike conventional structures neural network applied observer trained line performance proposed controller investigated simulation
treatment rainwater typically performed first use retain gross particles leaves date lack rainwater treatment systems high efficiency remove small suspended particles simple operation without energy consumption associated greenhouse gas emissions objective work develop test novel concept filtration particles raw rainwater energy usage self cleaning mechanism simple installation operation buildings purpose innovative concept developed based flow filtration flow operation concept tested building prototype treatment efficiency particle removal efficiency assessed three different filter media results showed system designed proposed concept operated effectively correct selection filter medium therefore proposed rainwater treatment concept offers opportunity enhance water security treating using rainwater buildings efficient simple energy free way elsevier rights reserved
natural streams characterized variation cross section geometry bed slope bed roughness hydraulic slope etc along channels resulting several interacting features system including effects discharge changes context sediment load etc quantitative qualitative assessment river flow dynamics requires sufficient knowledge hydraulics variables average flow condition theory expressed station hydraulic geometry relations site specific power functions relating mean stream channel forms water depth top width flow velocity flow area discharge studied since establishing robust relations requires pre assessment data quality means uncertainty analysis paper introduces recursive data filtering procedure find random systematic errors river survey data used produce robust informative relations method first verified synthetic data experiments real discharge stage ratings provided daily records geological survey national water information system dataset field river survey measurement data produces robust relations monitoring stations across elsevier rights reserved
information indicating variations induced menstrual cycle influence capacity young women respond stress physiological response stress changes across stages lifespan however spite great increase life expectancy way women react period characterized dramatic decline sex hormones sufficiently studied main objective study examine capacity respond recover acute social stressor post menopausal women compared young women second objective investigate consequences behavior self regulatory systems measured behavior cortisol heart rate speaking task front committee sixty seven women post menopausal pre menopausal follicular group group differences heart rate reactivity three groups found post menopausal women showed less cortisol reactivity stress also displayed higher percentage gestures speaking task reflecting pattern active coping compared young women post menopausal women behaviors reflect active coping strategies related better autonomic regulation contrast pre menopausal women cortisol changes seemed modulated passive reactive behaviors results emphasize importance considering age hormonal status coping processes including reactivity recovery stressful situations elsevier inc rights reserved
study examines men interested fashion interpret fashion data interviews adult men regularly read fashion fashion findings reveal men process fashion five modes women current study also demonstrates mens responses fashion categorized fashion engagement grid examines mens motivations fashion behavior study expands theoretical understandings gender research recommends elements attract male consumers
introduction one human milk peptides differed significantly preterm full term mothers study designed demonstrate biological characteristics antibacterial activity mechanisms common pathogens neonatal infection methodology analysis biological characteristics done bioinformatics disk diffusion method flow cytometry used detect antimicrobial activity killing kinetics measured using reader antimicrobial mechanism studied electron microscopy electrophoresis results bioinformatics analysis indicates derived showed significant sequence overlap antibacterial assays showed inhibited growth aureus analyses revealed antibacterial activity cytoplasmic structures bacterial cell envelope alterations combination dna conclusion conclude antimicrobial activity mechanism data demonstrate potential therapeutic value prevention treatment pathogens neonatal infection elsevier inc rights reserved
detection exogenous plant micrornas human animal plasma sera lies foundation exploring cross kingdom regulatory functions necessary establish standard operation procedure promote study field study plant mirnas assessed mixed fruits quantitative reverse transcriptase polymerase chain reaction qrt pcr values template controls standard curves mirna used evaluate specificity sensitivity qrt pcr obtain concentrations sixteen mirnas selected measured human plasma volunteers drinking values plant mirnas human plasma fell outside linear ranges standard curves remaining mirnas present high basal levels showed dynamic physiological pattern plasma absorption rates northern blotting used confirm qrt pcr results critical issues rna extraction internal controls also addressed authors published elsevier inc open access article license
flexible thermoelectric materials prepared melt mixing technique easily scaled industrial level hybrid systems carbon nanotubes copper oxide environmental friendly materials contain abundant earth elements melt mixed matrix namely polypropylene addition electrical network built inside effective charge transport effect addition determined corresponding concentration high concentration largely threshold phi change properties small contrast concentration close phi addition simultaneously increase electrical conductivity coefficient loose network formed coefficient increased electrical conductivity leading power factor composite
many studies highlighted widespread use skin containing women pregnancy remove dark spots women especially pregnant mothers using products risk poisoning sometimes clinical symptoms particularly early exposure studies shown prenatal postnatal exposure cause permanent neurological damage children furthermore cause women infertility birth defects even though several studies examined reproductive developmental consequences gestational exposure fish consumption dental studies assessed possible effects long term use containing skin products women childbearing age pregnancy outcome childrens health commentary aims information popular use containing skin sheds light readers limitations available data impact prenatal postnatal period urgent need assess adverse health effects applying products pregnancy lactation child growth development birth cohort studies data studies available women advised use topical skin pregnancy lactation elsevier gmbh rights reserved
paper generalized variable coefficient system studied via modified direct reduction method connected homogeneous balance method describe water waves fluid physics direct similarity reduction nonlinear ordinary differential system obtained solving reduced ordinary differential system new analytical solutions including solitary periodic types terms elliptic functions given variable coefficient system elsevier ltd rights reserved
deployment hydrogen technologies energy mix use hydrogen fuel cell vehicles expected significantly reduce european greenhouse emissions carry social cost benefit analysis estimate period socio economic conversion period replacement gasoline internal combustion engine vehicles becomes socio economically study considered hydrogen production mix five technologies natural gas processes without carbon capture storage biogas processes site production estimate two external costs cost use non renewable resources manufacture fuel cells measuring platinum depletion forecast carbon market approximately deployment cost hydrogen based transport early economic conversion targeted almost ten years saved considering hydrogen energy publications llc published elsevier ltd rights reserved
influence particle shape mechanical behavior sand woven geotextile interfaces wide domain soil density normal stress studied uniformly graded angular fine sand blend glass beads identical particle size distributions selected granular material experiments revealed impact particle shape peak residual friction angles maximum dilation angle interfaces granular media woven geotextile observed residual friction angles interfaces angular sand glass beads woven geotextile similar residual friction angles angular sand glass beads soil soil direct shear test understood peak friction angle maximum dilation angle angular sand woven geotextile slightly lower corresponding values angular sand soil soil direct shear test peak friction angle maximum dilation angle angular sand woven geotextile interface decrease increase normal stress experiments showed factors insensitive normal stress glass beads woven geotextile interfaces least range studied herein interfaces woven geotextile contact surface exhibit loss shear strength post peak regime behavior finally unified stress dilation law angular sand woven geotextile glass beads woven geotextile angular sand steel interfaces obtained elsevier ltd rights reserved
model human tissue report considers rate free radical generation solution water beta emitting uniformly dispersed decay discrete quantity energy creating large number free radicals short time within small volume determined beta particle range representing instantaneous power train randomly pulses time averaged power rate free radical generation derived analogous result theory electrical circuits known shot noise theorem reference dose rays producing identical rate free radical generation level oxidative stress shown increase square root absorbed dose far larger finding important consequences public health cases level shot noise exceeds noise floor corresponding equilibrium biological processes estimate noise floor made using example potassium beta emitting universally present living tissue elsevier ltd rights reserved
paper presents robust distributed algorithm solve general linear programs algorithm design builds characterization solutions linear program points modified lagrangian function show resulting continuous time point algorithm correct general distributed global parameter associated exact penalty function employed encode inequality constraints linear program motivates design discontinuous point dynamics convergence guarantees fully distributed scalable dimension solution vector also characterize robustness disturbances link failures proposed dynamics specifically show integral input state stable input state stable latter fact consequence general result also establish states algorithmic solution linear programming input state stable uncertainty problem data affects dynamics disturbance results allow establish resilience proposed distributed dynamics disturbances finite variation communication among agents simulations optimal control application illustrate results
soybean seed oil typically contains acid increasing content acid beneficial health production mutations genes reported increase seed acid content subset mutant families soybean cultivar population screened using reverse genetics identify mutations within genes although mutants identified using gel based four one mutants identified high seed acid content using forward genetic screening subsequent target sequencing successfully used non transgenic reverse genetic approach identify mutations genes controlling important traits however technique presents limitations traits oil composition due gene copy number similarities within soybean genome soybean present two copies two members three members reported phylogenetic silico analysis revealed two additional members gene family located chromosomes respectively presumed members localized chromosomes work discusses alternative solutions limitations gel based functional genomics due high copy number multiple gene family soybean
comorbidities associated psoriatic arthritis psa include cardiovascular diseases diabetes mellitus obesity study evaluated association psa common gastrointestinal diseases retrospective study performed largest health care provider database psa patients matched age sex randomly selected patients searched patients records presence disease reflux crohns disease ulcerative colitis irritable bowel syndrome ibs celiac disease test used compare continuous variables chi square test used categorical variables multivariate logistic regression models used assess association psa comorbidities psa associated crohns disease ulcerative colitis reflux ibs controlling known risk factors association remained significant psa crohns disease ulcerative colitis reflux significant association found psa celiac disease current study psa associated gastrointestinal morbidities including crohns disease ulcerative colitis ibs physicians treating patients psa aware associations
microscopy imaging single technology usually restricted single contrast mechanism multimodal imaging promising technique improve structural information obtained device test due different contrast mechanisms laser scanning microscopy confocal laser scanning microscopy optical beam induced current microscopy combination improve detection structures integrated circuits ics helps reveal layout imaging sensitive changes differently doped areas semiconductor metal transitions imaging mostly sensitive changes absorption reflection work present implementation imaging show first results using industry standard feature size analyzing types helps improve field side channel attacks find hardware possible spots laser fault attacks reverse engineering experimental results placed custom circuit board allows measure current imaging house built stage scanning microscope using near infrared nir laser diode light source allowing imaging substrate demonstrate possibilities using optical setup evaluating images threshold laser source
technology smart skin radar stealth belong active radar stealth active radar stealth important branch target radar signature control technology also known radar stealth technology smart skin radar stealth device mentioned united states patent detailed description device paper make quantitative analysis smart skin radar stealth device firstly basic working principle device described constraint equations electromagnetic field given secondly quantitative relationship phase shift incident frequency incident angle spatial relationship factors derived finally stealth performance influenced incident frequency incident angle spatial position discussed numerical simulation
article examines transformation rice farming commercial aquaculture implications gender roles relations womens access control resources household food security primary data collected sample households located across villages northern southern used study data analyzed using qualitative quantitative methods namely wealth ranking technique self assessment technique coefficient curve descriptive statistics commercial aquaculture increased farm income income inequality brought new sources employment changed gender roles relations altered womens access control resources altered household food consumption patterns increased market dependence food commercial aquaculture decreased workload women also weakened access control agricultural products women became dependent income lesser control use farm reduces women farmers diversification rice toward rice based high value crops aquaculture improves welfare society implies poor farmers including women provided better access improved technologies credit
june court ruled video games full free speech regulation violent game sales court also referred psychological research violent video games noted research contains many methodological flaws recent reviews many scholarly journals come similar conclusions although much debate continues given past statements american psychological association linking video game media violence aggression court particularly science likely psychologists one possible outcome psychological community increase statements linking violent games harm form defensive reaction however article author argues psychological community better served reflecting research considering whether scientific process failed even encouraging statements video game violence exceeded data ignored conflicting data although likely debates issue continue move toward caution increased dialogue scholars opposing sides debate necessary restore scientific credibility current article reviews involvement psychological science community brown entertainment association case suggests learn errors case future
aim study develop poly natural modified melt technique evaluate thermal behavior food packaging interactions ray diffraction xrd xrd observed structure systems natural clay possibly structure systems observed differential scanning calorimetry results natural systems showed small increase thermal stability whereas systems lower thermal stability high pure polymer natural evidenced test carbon dioxide production high weight loss material observed significant migration circumstances presented better thermal stability high possibly contact food wiley periodicals inc
studies reported analyze factorial structure facebook addiction italian questionnaire variant item youngs internet addiction test study tested psychometric properties using exploratory factor analysis study performed confirmatory factor analysis verify factorial structure identified results confirm presence four factor model accounting percent total variance plus general higher order factor best fits data relationships factor scores personality facebook usage explored
due high computing demand whole trip train dynamics simulations iterative nature optimizations whole trip train dynamics optimizations using sequential computing schemes practically impossible paper reports advancements whole trip train dynamics optimizations enabled using parallel computing technique parallel computing scheme whole trip train dynamics optimizations presented discussed two case studies using parallel multiobjective particle swarm optimization parallel multiobjective genetic algorithm respectively performed optimize friction draft gear design linear speed achieved using parallel computing cut computing time months just days optimized results using agreement pareto identified provide technical evidence railway manufacturers operators
objective given importance emotion regulation aetiology maintenance psychopathology investigated subjective reports group bipolar individuals compared results group depressed healthy control participants additionally explored impact psychotropic medication method participants diagnosed bipolar disorder participants diagnosed major depression healthy controls administered multifaceted measure also explored impact antidepressants explored whether amount psychotropic medication differential effect results participants scored significantly higher groups overall suggesting diagnostic groups difficulties regulating emotions additionally comparing groups participants depression showed difficulties acceptance engaging goal directed behaviour impulsivity access effective strategies contrast participants showed selective difficulties accessing emotion regulation strategies compared group exploratory part study failed find positive effect antidepressants impact amount psychotropic medications conclusions difficulties regulating emotions differentiate healthy controls diagnostic groups furthermore participants showed less difficulties regulating emotions still difficulties assessment differences appears possible multifaceted measure utilised additionally results showed antidepressants improve overall amount medication associated although robust conclusions regarding medications possible exploratory part study appears precise effect psychotropic including antidepressants area need research
japan students poor adjustment school life school recognized nation wide problem study examined link absence mothers active engagement infants childrens risks poor adjustment toward elementary school life ages methodswe used japanese national longitudinal survey follow social mothers engage infants employed propensity score matching analyses control confounding socio economic factors matched mothers active engagement without various social parental characteristics educational attainment household income results matched pairs observed higher risks poor adjustment school life among japanese children lacked mothers active engagement example relative risk confidence interval inability get along others group setting age inability get along teachers age findings corroborate previous findings emphasize importance providing enriched environment infants social development indicate need intervention caregivers lack appropriate skills
systematic review scientific articles violence women situations women treated traditional gender roles spanish films presented investigation allowing situations aggressive acts remain framed exclusively domestic sphere surprisingly articles film reviews focus women roles women violence famous film even mentioned simple example spanish film gender violence evident
background approach low density lipoprotein cholesterol ldl lowering becomes increasingly intensive accurate assessment ldl low levels warrants closer attention individualized clinical efficacy safety evaluation aimed assess accuracy ldl estimation low levels equation clinical standard compare accuracy novel big data derived ldl estimate methods individuals ldl compared accuracy novel ldl values relation direct measurements vertical auto profile examined differences estimate classification according levels initiating additional safety per clinical practice guidelines results values less measurement median difference percentile respective values novel estimation among ldl classification low individuals compared novel estimation conclusions estimation even lower ldl values novel methods even inaccurate often value underestimated translates unnecessary safety alarms reduced half estimation using novel method
heuristics achieved great various fields investigation relationship algorithms problem hardness hot topic research field related research work contributed much understanding underlying mechanisms algorithms problem solving however existing studies consider traditional combinatorial problems case studies study taking next release problem requirements engineering case study investigate relationship software engineering problem instances heuristics employ evolutionary algorithm evolve instances uniquely hard easy target heuristic greedy randomized adaptive search procedure randomized paper use feature based method estimate hardness evolved instances respect target heuristic experimental results demonstrate evolutionary algorithm used evolve instances uniquely hard easy solve moreover features enable estimation target heuristics performance
background micrornas group small rnas regulate gene expression level regulate almost every aspect cellular processes study investigated whether mir regulates pulmonary fibroblast activation results found mir regulated fibrotic lungs fibroblasts experimental mouse model pulmonary fibrosis overexpression mir vector inhibited tgf beta stimulated mrna expression alpha smooth muscle actin protein expression alpha smooth muscle actin human pulmonary fibroblasts mir also reduced contractile activity tgf beta receptor identified targets mir untranslated region luciferase reporter western blotting assays conclusions results suggest mir anti fibrotic microrna inhibits fibroblast activation targeting tgf receptor discovery provide new targets therapeutic interventions idiopathic pulmonary fibrosis
aim study present effect based design activities students attitudes towards learning computer programming self efficacy beliefs levels academic achievement research pretest posttest control group semi experimental study study group research consisted students attending faculty engineering experimental group administered teaching method based design activities hand control group topics directly taught via research data collected via implementing academic achievement test attitude towards learning programming scale cronbachs alpha computer programming self efficacy scale cronbachs alpha obtained findings education using design activities contributed academic success students terms programming language compared traditional method
filter media one geotextile materials used drainage filtration particularly soil reinforcement civil engineering due appropriate properties low cost however current understanding durability stability material real service conditions especially severe long term conditions completely limited work presents investigation chemical aging commercial nonwoven membrane different temperatures environments relation morphology mechanical properties molar mass results showed significant reduction mechanical properties term tensile strength resistance forces membrane aging process due chemical degradation molar mass mechanical properties changes temperature showed complex dependence material properties environmental conditions based obtained results lifetime material different temperatures determined use model results provide useful information better understanding phenomena occurring chemical aging nonwoven membranes help predict service lifetime material conditions use service elsevier ltd rights reserved
experience childhood trauma stressful life events associated subsequent development variety mental health conditions including psychotic illness recent research identifying adolescents young adults clinical high risk psychosis allows prospective evaluation impact trauma adverse life events psychosis onset outcomes addressing etiological questions answered studies fully psychotic non clinical populations article provides comprehensive review current emerging literature trauma adverse life events population youth endorse lifetime history childhood traumatic events victimization bullying several studies shown experience predicts psychosis onset among individuals literature influence recent death one remains inconclusive multiple models proposed explain link trauma psychosis including stress vulnerability stress sensitivity hypotheses cognitive processes neurobiological mechanisms hypothalamic pituitary adrenal axis despite individuals endorse either clinical trials conducted evaluating interventions trauma youth date furthermore current process formal identification assessment trauma impact youth inconsistent research clinical practice recommendations improving trauma assessment treatment future research directions field provided
paper discusses novel method check effectiveness combining deterministic generalized basis filters stochastic autoregressive moving average filters state space representation effectiveness models improved coupling model presence disturbances work particle swarm optimization pso algorithm used determine poles filter
inflammation local response infection tissue damage mediated activated macrophages monocytes immune cells release cytokines mediators inflammation long time humoral cellular mechanisms studied role regulating immune response recent advances field immunology neuroscience also specific neural mechanisms interesting therapeutic potential called cholinergic anti inflammatory pathway cap described control innate immune responses inflammation potent manner early developed technique stimulates nerve mimics effect pathway methodology based electrical stimulation nerve low voltage frequency order avoid side effects heart rate variability electrical devices stimulation now available making easy set methodology laboratory goal research investigate potential involvement cap unfortunately based earlier attempts failed use original protocol induced inflammatory response either high suitable enzymatic metabolism properties different settings original surgery protocol remained mostly unchanged conditions regarding inflammatory induction time point improved fit purposes investigate involvement cap limited inflammatory responses modified version original protocol presented includes longer time range nerve stimulation analysis associated lower induction inflammatory responses additionally decreasing level lps also came across new observations regarding mechanistic properties spleen
student learning approaches identified remove mitigate factors encourage surface learning develop course encourage deep learning instructors organize appropriate learning activities ensure students engage active learning civil engineering students likely develop deep approach toward learning therefore identifying civil engineering students learning approaches important factor academic success present study examined learning approaches civil engineering students three universities turkey extent learning approaches related gender age type university year study construction management course success data collected civil engineering students undergraduate programs three different universities using revised two factor study process questionnaire questionnaire directly administered students participants responded survey study findings revealed week correlations learning approaches age year education moderate correlations learning approaches construction management success
objective serum concentrations estradiol testosterone measured mass spectrometry based assays remain measured normal postmenopausal women order avoid risk non physiological systemic exposure elevated serum concentrations two sex steroids methods serum nine metabolites measured time intervals first days daily administration validated mass spectrometry based assays results biologically significant change individual serum concentrations observed importantly sulfate androgen metabolites also remained within normal values thus confirming absence biologically significant systemic exposure line using data literature comparison made serum normal postmenopausal values following administration tablets conclusion clinical program atrophy shown efficacy safety present data illustrate detail serum levels individual sex steroids metabolites derived data obtained line physiology confirm action limited serum concentrations sex steroids maintained within normal values menopause thus protecting uterus likely tissues
paper explore nature explanations action guided implicit bias claim explanations significant benefits spite obvious costs benefits otherwise subject time explanation offered start kinds cases mind phenomenon focusing common features introduce notion capture status cognitions obvious faults significant benefit cognition delivers benefit subject otherwise alternative less faulty cognitions deliver benefit unavailable subject time ask whether explanations actions guided implicit bias benefits whether genuine alternatives forming explanation circumstances subjects basis analysis explanations actions guided implicit bias argue explanations potential conclude evaluation explanations action guided implicit bias story one takes account context explanation occurs published elsevier inc
low permeability engineered landfill barriers often consist combination geosynthetics mineral layers even though numerical modelling software applied landfill design process lack data mechanical performance landfill barriers available validate calibrate models instrumentation installed landfill site monitor multilayer landfill system physical performance system comprises clay layer high density polyethylene geotextile sand data recorded site includes geosynthetic displacements strains fibre optics strain stresses imposed liner pressure cells addition temperature readings collected installed surface clay surface using pressure cell air temperature using paper presents readings collected throughout period three years compares measured performance corresponding numerical modelling system stages construction numerical modelling predictions system behaviour construction comparable measurements geosynthetics covered soon placement however geosynthetics left exposed sun extended period time situ behaviour geosynthetics replicated numerical analysis study highlights significant influence effect temperature geosynthetics displacements simple thermal analysis exposed geosynthetics used support explanation observed behaviour elsevier ltd rights reserved
meet stringent spectral mask requirement ieee novel spectral shaping buffer new automatic calibration proposed paper introducing floating current buffer second order product output calibrate buffer analog signal processing methods average power extraction residual accurate quantization presented along error tolerant decision making logic sample human body communication transmitter designed cmos process simulation results show spectral mask suppressed satisfying ieee standard specification
study presents model integrated design light electric vehicle front wheel single person battery powered consists battery inverter outer rotor permanent magnet synchronous motor connected wheel efficiency inverter motor analyzed new european driving cycle calculate losses efficiency power electronics inverter used analytical models provide fat less accurate result useful optimization purposes accurately predict efficiency finite element model used models validated test correspondingly good agreement measurements calculated results achieved parameter study performed investigate influence detailed component parameters outer rotor radius gear ratio number pole pairs stator average efficiency
paper deals automatic decomposition experimental frequency response functions mechanical structures decomposition based green function representation free systems determination impulse dynamic subspace system matrix formulated poles calculated directly means corresponding contribution element impulse dynamic subspace determined sufficient decomposition corresponding carried presented dominant modal decomposition method mode shapes modal participation vectors modal scaling factors identified using decomposed analytical example presented along experimental case studies taken machine tool industry elsevier ltd rights reserved
date understanding development novel treatments mental illness hampered inadequate animal models instance unclear extent commonly used behavioural tests animals inform mental affective aspects schizophrenia link pathophysiological processes animal model clinical findings utilized recently developed mouse model detailed investigations cortical neuronal engagement pre processing auditory information two back translational auditory paradigms also investigate compromised putative fast function restored pharmacological intervention using channel chronic multi array electrodes primary auditory cortex used record single cell firing putative animals processing auditory sensory information find decreased amplitude response auditory stimuli reduced recruitment fast steady state gamma oscillatory activity results resemble recordings patients schizophrenia furthermore probability fire low intervals auditory stimulation reduced mice effect partially reversed channel modulator study offers insight consequences neuronal level carrying furthermore points deficient functioning potential pathophysiological mechanism schizophrenia suggests therapeutic potential channel
deregulated electricity markets independent system operator iso power system supply demand balancing process typical day iso electricity demand forecast next day gives participants option prepare offers meet demand order reliable power system successful market operation crucial estimate electricity demand accurately paper develop hourly demand forecasting method annual weekly daily using linear model takes account harmonics variations modulation diurnal periodic variations seasonal variations electricity demand exhibits cyclic behavior different seasonal characteristics model based solely sinusoidal variations predicts hourly variations without using climatic information method applied turkish power market data period predicts demand daily weekly within error margin mean absolute percentage error norm also discuss week day consumption profiles infer proportion industrial domestic electricity consumption elsevier ltd rights reserved
sleep fundamental biological process crucial survival health humans many circumstances like physiological mental disorders environment lifestyle affect healthy sleep date different sleep disorders internationally recognized cover broad field medical areas analysis human sleep typically based multidimensional recordings called therefore research often includes digital signal processing clinical sleep research inherent multidisciplinary field inter institutional interdisciplinary collaborations required address complexity sleep regulation disturbance date collaborative sleep research poorly supported systems particular management processing challenging large variety devices data formats measurement procedures quality variations consistent data processing manuscript introduce virtual research platform supporting inter institutional data sharing processing infrastructure based free open source neuroimaging research platform coupled service oriented architecture scalable virtualization back end system capable local data mapping standardized set parameters automatic quality assessment terms quality measures derived manual scoring sleep associated events american academy sleep medicine standard diagnostic analysis sleep medicine elsevier rights reserved
composite samples prepared fused high purity aluminum powder creep test carried degrees studied results show creep rate sample without aluminum addition decreases gradually creep properties composite material improved aluminum powder addition sample demonstrating increase creep rate physical properties samples enhanced aluminum powder addition mechanism improvement sample analyzed different characterization methods kinetics calculations results indicates phases formed creep test acting reinforcing phases therefore enhance creep performance samples published elsevier masson sas
protein coupled receptor exciting promising target treatment type diabetes mellitus study three dimensional quantitative structure activity relationships comparative molecular field analysis comparative molecular field analysis region focusing carried novel series protein coupled receptor agonists quality model built hip algorithm best model indicated feature hydrogen bond acceptor hydrophobic existed around active compounds quality model satisfactory utilized search zinc database virtual screening task obtained compounds subjected filter first gold algorithm discover potent energy difference highest occupied molecular orbital lowest molecular orbital gap implies high reactivity active molecule active site protein addition molecular electrostatic potential energy density functional theory level confirms results molecular docking silico absorption distribution metabolism excretion toxicity risk assessment analysis carried seven highest gold score fitness six new virtual screening diverse structures reported new scaffold candidates protein coupled receptor agonists
based second quarter construction beijing fourth quarter data concentrations emissions beijing beijing agricultural output output value gross output value food industry control variable use var models measurement software building construction industry development beijing relationship concentration emissions model study building industry relationship results showed growth gross output value construction concentration emissions beijing certain adverse effects finally construction construction industry development emissions suppression lines put forward policy energy saving green building
wastewater contains significant quantities thermal energy consequently heat recovery systems provide urban areas additional source renewable energy heating buildings however certain treatment processes wastewater treatment plant temperature sensitive water protection perspective therefore imperative heat recovery systems negatively affect performance wastewater treatment regard practical implication question arises find locations best suitable wastewater heat recovery systems suitability characterised meeting energy supply water pollution control requirements article introduces methodological framework procedure evaluate suitability potential heat recovery site integrating perspectives framework incorporates decision support criteria planning principles energy planners water authorities application case study proved procedure criteria principles addition also delivered comprehensive information spatial temporal wastewater temperature development regarded system elsevier rights reserved
till last decade skin care category consumers like spend india strong economic performance demographic structure ensuring great future cosmetic industry need successful bring innovation price products efficiently new product innovation defined degree individual adopts innovations relatively earlier members social system diffusion refers process innovation communicated certain channels time among members social system became vocal habits sharing self details television media led fairness surprising leading cosmetic manufacturers introducing skin care lines specifically tailored males present study attempts build possible associations based previous researches socio demographics perceived innovation characteristics consumer new product adoption behavior owing product innovations skin care range special reference fairness males
fish main contributors arsenic diet found particularly algae blue filter contain less relatively inorganic arsenic whereas fatty fish contain compounds present smaller amounts include oxide sulfur containing toxic carcinogenic humans excreted urine producing reactive intermediates process less known new insight indicates results urinary excretion possibly also producing reactive arsenic intermediates recent findings also indicate pre systematic metabolism colon microbiota play important role human metabolism processing also result transformation elsevier gmbh rights reserved
statistical models involve two part mixture distribution applicable variety situations frequently two parts model binary response variable model outcome variable conditioned binary response two common examples zero models count data two part models data recently particular interest use models analysis repeated measures outcome variable time aim review consider motivations use models context highlight central issues arise use examine two part models zero heavy count data also consider models count data two part random effects distribution
human mandible said arise ossification however true entire body mandible cartilage prone ossification least anterior part canine region also within processes cores eventually undergo ossification furthermore number additional single arising fetuses located predominantly within bone sides dental compartments mostly dental become shaped diameter around also found older stages oldest specimen used study report intended visualize single histologically reconstructions images although singular tissue within mandible remains cartilage reconstructions clearly show aforementioned independent thereof derived separate locations within mandibular bone reasons lead remained unknown far elsevier gmbh rights reserved
objectives prospectively evaluate pregnancy stated intentions pregnancy occur among emergency contraception users explore differences women selecting copper intrauterine device iud oral levonorgestrel lng regarding hypothetical pregnancy plans actual pregnancy actions subsequent unintended pregnancies study design prospective observational trial women received iud oral lng without cost barriers baseline participants completed visual analogue scale measuring pregnancy trying hard get pregnant trying hard get pregnant self reported plans abortion adoption parenting pregnancy test come back positive pregnancies tracked months actions regarding unintended pregnancies compared method groups results enrolled women chose iud oral lng pregnancy baseline low difference groups iud group lng group fifty four women experienced unintended pregnancies pregnancy plans baseline changed women became pregnant groups differ hypothetical pregnancy intention agreement hypothetical pregnancy intention actual pregnancy action conclusions women presenting state high desire prevent pregnancy regardless method selected considering hypothetical pregnancy half women plan respond situation actual unintended pregnancy half altered plan clinical trial registration number identifier
study aimed optimizing horizontal subsurface flow constructed improve hydraulic performance pollutant removal efficiency groundwater modeling package used optimize three design parameters length width ratio inlet outlet length ratio substrate size configuration using optimized parameters three pilot scale built treat actual wastewater model validation used tracer test evaluate hydraulic performance investigated pollutant spatial distributions removal efficiencies conclude suitable designing accurately predicting increasing hydraulic conductivity surface bottom layers improve performance however effect vegetation decreased hydraulic conductivity surface layer considered improve simulation results multilayer substrate configuration increasing hydraulic conductivity surface bottom layers significantly increased pollutant removal compared monolayer configuration spatial variation pollutant transport degradation filling substrate showed multilayer configuration able increase use available space moderately reduced short dead zones thus multilayer higher experimental retention times effective volume fractions hydraulic efficiencies lower short compared monolayer operating similar conditions
objective extracellular deposition beta amyloid beta peptide main finding pathophysiology alzheimers disease leads oxidative damage apoptosis neurons medicinal plant family neuroprotective activity present study investigated protective effect acidic fraction beta induced oxidative stress apoptosis cultured cerebellar neurons additionally investigated possible role receptor materials methods study vitro experimental study performed mice cultured pre incubated different concentrations acidic fraction hours followed incubation beta additional hours also pre incubated acidic fraction followed incubation beta used bromide mtt assay measure cell viability acetylcholinesterase activity reactive oxygen species ros production caspase activity measured incubation iodide staining performed detect apoptotic cells results acidic fraction protect beta induced cytotoxicity protective effect acidic fraction activity ros production lipid peroxidation caspase activity increased beta incubation acidic fraction ameliorated factors decreased number apoptotic cells conclusion results indicated protective effect acidic fraction mediated receptors fraction protect antioxidant anti apoptotic activities
crack cocaine abuse dependence severe public health problem sometimes crack cocaine smokers show behavioral changes symptoms similar observed severe mental disorders like schizophrenia although use easily detected smokers urine blood tests time cocaine biomarkers become addition schizophrenia diagnosis limited clinical interviews precise clinical tests mental disorder remain unknown employing metabolomics based nmr spectroscopy herein showed blood serum metabolites used discrimination users schizophrenia patients groups two groups showed greatest differences around eleven moreover seven possible peripheral metabolites enough differentiation crack cocaine users healthy controls results contribute better understanding crack cocaine biochemical effects enable precise diagnosis crack cocaine biomarkers absent urine blood crack cocaine users
objective paper analyze potential benefits energy storage light rail networks primarily terms supply energy reduction present methods used method analysis based train movement electrical network load flow simulation results analysis indicate potential energy saving due introduction energy storage energy saving effects energy transfer one train another also considered additional benefits energy storage terms voltage drop improvements reduction peak power loading demonstrated test case scenario novel traction electrical network load flow algorithm using modified nodal analysis described detail allows intuitive representation network elements trains direct solution currents
purpose determine dose dependent effects testosterone administration cognition women low testosterone levels methods women without total testosterone free testosterone received standardized estradiol regimen week run period randomized receive weekly injections placebo testosterone weeks total testosterone measured serum free testosterone levels measured equilibrium dialysis cognitive function evaluated using comprehensive battery standardized neuropsychological tests baseline weeks results women baseline end treatment cognitive function data constituted analytic sample five groups similar baseline mean treatment total testosterone concentrations placebo groups respectively significant changes spatial ability verbal fluency verbal memory executive function observed treatment arm compared placebo even adjustment baseline cognitive function age education multiple regression analysis show significant relation changes testosterone concentrations change cognitive function scores conclusion short term testosterone administration wide range doses weeks women low testosterone levels neither associated improvements worsening cognitive function
interest behind use component based software engineering divide information system subsystems less complexity reduction time faster development enhancing productivity software systems developed components software units offer set services exposed interfaces indispensable role component based development component model defines components built assembled component intended provide specific services management combination communication system units manager component important complementary paradigm development software systems functionalities related consistent model presented paper proposes component called manager software component based viewpoint vision system user actor assembly base component system components
objectives three direct oral anticoagulants now widely used clinical practice patients requiring perioperative interruption heparin bridging still discussion show first time influence concomitantly used laboratory assays methods experiments healthy donors nine patients treated investigated measurement performed routine methods acl top direct inhibitor heparin usa calibrated heparin low molecular weight heparin additionally reagent reagent instrumentation laboratory germany additionally quantified liquid chromatography mass spectrometry linear regression model used estimate effect results influence demonstrated anti testing methods inhibiting drugs affected anti testing methods specific ways compared heparin alone measurement samples basic concentration displays dramatic increase samples patients therapeutic intake spiked showed expected pharmacokinetic profiles increased pharmacodynamic effects conclusion direct inhibitors exhibit distinct effects assay results used concomitantly interactions considered interpretation assay results bridging therapy
based self help recommended first stage treatment mild moderate eating disorders provision guidance enhances outcome literature evaluating exclusively guided self help gsh systematically reviewed methodsthe aim establish effectiveness gsh reducing global eating disorder psychopathology abstinence binge eating compared controls results pooled using random effects meta analysis heterogeneity explored using randomised controlled trials met inclusion criteria results showed overall effect gsh global eating disorder psychopathology binge abstinence strong evidence association diagnosis binge eating disorder binge abstinence interventions need adapted address features binge eating research required help understand effectiveness gsh children young people high dropout rates technology enhance interventions copyright john wiley sons ltd eating disorders association
background aims incidence menstrual symptoms reported high cyclic women symptoms including anxiety pain associated cortisol receptors widely distributed brain areas associated behavior therefore current study aimed assess cortisol response car throughout menstrual cycle correlate pain perception trait anxiety materials methods car assessed measuring salivary cortisol min following women age years various stages menstrual cycle phases progesterone estradiol concentrations also determined saliva samples assess cyclic changes self reported pain trait anxiety menstrual symptoms assessed visual analog scale vas state trait anxiety inventory daily record severity problems respectively results estradiol significantly elevated period remained high early phase progesterone increased phase post cortisol values increased phase phase blunted flat car positive significant correlations found cortisol estradiol cortisol progesterone estradiol progesterone symptom scores higher phases phases pain perception highest followed phase conclusions car blunted suggesting cortisol play phase specific role regulation cycle additionally symptoms including pain severe ovarian steroid levels reduced phase elsevier ltd rights reserved
process design dft procedure test points addition significantly time consuming especially systems become complex resolve problem efficient method allocate test points based multi signal flow graph proposed paper first dependency matrix describes relationship signals candidate test points presented assuming output modules multi signal flow graph considered candidate test point thus test point allocation problem searching optimal candidate test point set detect isolate signals genetic algorithm applied dependency matrix search optimal test point set finally proposed method examined multi signal flow graph result shows proposed method allocate optimal test points acceptable time
work shows main pathways transformation surface waters direct quantum yield reaction significant second order rate constant possibly dissolved organic carbon higher reaction states dissolved organic matter modelled half life time environmental waters range days weeks suggests importance comparable transformation main pathways yields derivatives ring opening compounds elevated concentration levels case state used proxy ring rearrangement also hypothesised produce different transformation products microbial human metabolism thus relevant used markers reaction pathways environmental waters elsevier ltd rights reserved
paper provides state art review design construction multiple span suspension bridges starts brief introduction key issues associated multi span suspension bridges gives historical review bridge form together list multi span suspension bridges constructed present day paper looks compares deflection characteristics classic suspension bridge multi span suspension bridges paper outlines problems associated bridge form primarily caused increased flexibility ways overcome actual bridges exist existed referred paper also looks current proposed future projects using multiple span suspension bridges much recent work subject carried china abstracts recent chinese papers included paper
effective disease management crops crucial sustain food security potential losses crop production worth key success plant disease management ability detect causal pathogen early accurately polymerase chain reaction pcr gold standard nucleic acid based diagnostics apart pcr within last decade development technique called loop mediated isothermal amplification lamp facilitated development hundreds simple assays plant disease diagnostics now lamp publications per year identify plant disease pathogens among lamp assays available pathogen detection plant viruses bacterial plant diseases fungal plant diseases several provide comprehensive analysis lamp assays available detecting plant diseases including various detection used also discuss avoid pitfalls developing lamp assays finally offer perspectives applications lamp plant disease management addressing questions extent assays helpful whether used outside laboratory review researchers developing lamp assays plant disease diagnostics
manuscript presents steady state stability analysis using frequency plot careful analysis fine stability region also paper presents comparative estimation conventional proportional integral derivative pid controller genetic algorithm based pid controller modified controllers simulated using matlab performance analyzed result analysis shows based pid controller conventional pid control method design simulation experimental results khz based resonant converter presented work applicability arm advanced machine processor also investigated implementing based pid controller marine applications
vortex installed measure fluid flow rate easily disturbed strong transient impact application fields components impacting pipeline manual pipe opening closing valves strong transient impact vortex flow sensor makes vortex output wrong measurement results current commonly used digital signal processing method solve problem experimental setup built laboratory study impact interference large number vortex flow sensor output signals collected characteristics transient impacts vortex sensor analyzed describe type signal quantitatively pattern transient impact signal amplitudes increase attenuate gradually segmented kalman filter based digital signal processing method proposed according pattern data segment containing strong transient impact found first transient impact power reduced filtering data segment second spectral analysis filtered signal maximum peak spectrum extracted vortex flow signal finally algorithm implemented real time low power microcontroller gas water flow experiments conducted verify validity reliability transient impact algorithm
paper studies estimation frictional torque gear shifting operation electric vehicle equipped automated manual transmission electric vehicle discussed dynamical model powertrain electric traction motor system two speed developed order estimate frictional torque indeed unknown input dynamical system assumed generated autonomous system thereafter augmented state space representation actual state variables forms basis observer design provided observability augmented system discussed deterministic observer stochastic kalman filter designed order estimate frictional torque estimation based measuring angular velocities electric motor ring together known electromagnetic torque traction motor performance observers assessed experimentally means test rig results demonstrate satisfactory performance stochastic observer system encounters process measurement noise likely happen practice
silicon photo regarded novel photo detectors replace conventional photo multiplier tubes however breakdown voltage dependence ambient temperature results gain variation similar degrees severely limits application device experiments wide range operating temperature especially space experimental setup established investigate temperature bias voltage dependence gain multi pixel photon counter gain breakdown voltage dependence operating temperature approximated linear function similar behavior diode measured temperature coefficient breakdown voltage degrees according fact analog power supply based two diodes operational amplifier designed positive temperature coefficient measured temperature dependence designed power supply degrees different output voltages designed power supply bias voltage temperature variation similar degrees gain variation biased voltage reduced degrees degrees biased designed power supply gain control detailed design performance analog power supply temperature range similar degrees degrees discussed paper
paper illustrate proposed method control combines outputs several individual controllers improve global control complex nonlinear plants first part paper illustrate proposed method consists two levels top level fuzzy system represents superior control designed adjusting behavior individual fuzzy controllers lower level test approach consider problem flight control requires several individual controllers also comparison performed hierarchical control strategy compared simple control approach using student test paper show proposed method outperforms conventional fuzzy control approach optimal design proposed control architecture genetic algorithm also applied tune parameters fuzzy systems optimal fashion elsevier rights reserved
movement data collected gps technologies increasingly common difficult visualize due occlusion movements displayed maps additional challenge extraction useful higher level information meetings derived raw movement data present design study tool visualizing places visited behaviors individual actors also meetings multiple actors first present taxonomy visualizations movement data consider tasks support analyzing movement data especially meetings multiple actors argue charts many advantages understanding movements meetings small groups moving entities present design chart people within locations locations within people along vertical axis show time along horizontal axis chart sorted activity level filtered using weighted matrix showing meetings people empty time intervals chart automatically folded transitions yielding multi focal view case studies demonstrate utility prototype
primary type rare autosomal recessive error metabolism caused deficiency liver specific enzyme alanine aminotransferase disorder results excessive urinary excretion causing recurrent glomerular filtration rate declines due progressive renal involvement leading systemic diagnosis based clinical findings urine assessment enzymology dna analysis early initiation conservative treatment high fluid intake inhibitors calcium aims maintaining renal function chronic kidney disease stages best outcomes date achieved combined liver kidney transplantation
objective deformity common complication late stage ankylosing spondylitis aim study compare correction efficacy ankylosing spondylitis using preoperative designs splice methods retrospective study patients ankylosing spondylitis deformity underwent correction department spinal surgery affiliated hospital university november preoperative design using splice applied patients preoperative design using applied patients patients followed months postoperative angle error correction efficacy last follow compared two groups results significant differences errors postoperative actual preoperative planned angle group splice group spinal sagittal global sagittal vertical axis group degrees respectively splice group degrees respectively disability index research society questionnaire score group significantly higher splice group independently associated improvements scores conclusion compared design using traditional splice design using software achieve smaller angle error better postoperative spinal balance sagittal plane
mouse isolated kidney technique keeping mouse kidney vivo conditions functional prerequisite studying physiology isolated organ many innovative applications possible future including perfusion kidney administration anti rejection genome editing drugs high doses prime kidney transplantation time perfusion kidney manipulated renal function assessed various pharmaceuticals administered procedure kidney transplanted processed molecular biology biochemical analysis microscopy paper describes surgical technique needed vivo perfusion mouse kidneys details perfusion apparatus given data presented showing viability kidneys preparation renal blood flow vascular resistance urine data functional transmission electron different segments morphological western transport proteins different segments molecular readout
objective test hypotheses children autism spectrum disorder asd higher screen time children nationally representative sample children asd among children exceed american academy pediatrics screen time recommendation hours less day methods national survey childrens health nationally representative survey asked parents report childs aged years average daily media usage asd subpopulation compared children without asd non asd differences compared design corrected tests regression models estimated groups separately adjusted tests used rigorously test hypotheses results half children exceed screen time recommendation compared non asd children asd similar amounts total screen time hours per day hours per day media video time computer mobile device leisure time children asd age gradient general population computer mobile device usage children asd represented among high users hours per day data support hypotheses conclusions large nationally representative sample evidence children asd differ screen time habits children groups high screen time use caution assuming children asd higher risk exceeding screen time recommendations efforts promote adherence recommendation needed neither target exclude children asd
dysfunction central borderline personality disorder bpd recent research focused role oxytocin bpd particularly regarding associations activity symptoms genetic polymorphisms oxytocin receptor coding gene bpd experimental modification interpersonal core problems patients bpd towards threat detection non verbal behaviour social interaction intranasal application methodsa literature medline review performed using keywords oxytocin borderline personality disorder secondary literature trauma attachment relation also considered relevant findings suggest bpd associated enhanced defensive mechanisms avoidance behaviour moreover gene environment interaction concerning polymorphic variations gene childhood adversity bpd suggests genes convey developmental flexibility differential susceptibility environmental whereby bpd poor outcome end spectrum view conflicting literature needs studied carefully whether serve therapeutic agent given adjunct psychotherapy bpd research role also required regard prevention non genetic intergenerational transmission bpd role bpd also benefit research non human animals targeting interaction early adversity availability directly practitioner points study oxytocin contribute understanding neurobiology borderline personality disorder oxytocin critically involved attachment security methylation oxytocin receptor play role epigenetic modulation early adversity intranasal application oxytocin useful therapeutic adjunct psychotherapy insecure attachment childhood adversity produce differential neurobiological effects system borderline personality disorder insufficient knowledge oxytocin interacts testosterone dopamine serotonin also important key players experience social reward stress unclear whether oxytocin beneficial preventing intergenerational non genetic transmission borderline personality traits
cells accumulate variety tissues aging develop senescence associated secretory phenotype entails secretion inflammatory cytokines chemokines proteases growth factors components alter microenvironment within tissues affect function neighboring cells eventually lead local systemic dysfunction jak pathway highly activate non cells inhibition jak pathway suppresses cells age related tissue dysfunction targeting cells promising way improve aged population elsevier ltd rights reserved
paper presents innovative variable regulated high voltage power supply output voltage ranging maximum current consists switched mode power supply followed linear regulator power supply rejection ratio digital control module consists microcontroller small digital display isolated inter integrated circuit interface isolated sensor current sensor bit analog digital converters adc read output voltage current also digital analog converter dac controls linear regulators output voltage
background objective study assess clinical computed tomography outcomes least years head treat osteoarthritis hypothesis head provides similar outcomes achieved head implants materials methods single centre retrospective study included heads implanted mean patient age diagnosis years diagnoses osteoarthritis intact necrosis osteoarthritis chronic instability post traumatic osteoarthritis chronic inflammatory joint disease validated clinical scores radiographs surgery last follow compared results mean follow months complications occurred implants revision surgery reverse shoulder replacement required cases mean months treat wear tear last follow implants require revision surgery mean constant score implants mean mean mean increase cavity depth mean increases medial lateral offset respectively pre operative factors significantly associated failure tear erosion discussion found high failure rate related wear progressive impairment although showed evidence implant previous studies head implants showed better outcomes given low medium term prosthesis survival rate now reserve head osteoarthritis without damage published elsevier masson sas
malignant common primary brain tumors critical characterizes aggressive brain leads conventional forms therapy micrornas small rnas found regulate targets specific binding untranslated region mrna recent advances understanding molecular biology tumors revealed microrna mirna disruption play important roles pathogenesis mirna alterations found serum patients study studied expression profile mir different stages tissues two human cell lines cells found levels mir decreased cells compared normal human furthermore levels mir decreased gradually pathological stages also identified novel target mir luciferase reporter system furthermore expression levels dramatically increased pathological stages increasing finally levels negatively correlated mir tissues data provided novel evidence mir development human
gives insights surroundings benefits many aspects life nowadays massive sensors deployed sense kinds parameters environments tens even sensed data collected need analyzed surveillance purposes many perspectives users always issue queries according specific spatial temporal applications relational databases large scale high rate insertions nosql database considered feasible solution popular key value store system capable solve storage problem fails provide built spatio temporal querying capability many previous works tackle problem designing schema designing row key column key formation believe effective solution paper address problem nature level propose index structure built component spatio temporal index adapted two level architecture suitable process spatio temporal queries composed index meta table first level region index second level indexing inner structure regions base structure two common queries range query query solved proposing algorithms respectively achieving load balancing scalable query two optimizations also presented implement conduct experiments real dataset results show design outperforms previous work many aspects
measurement core losses electrical steel considered essential step machine design process accordingly calibration field sensor measurements magnetic field strength importance core loss measurements estimation electrical machine efficiency due field surface coil concern raised regarding certainty measured field paper presents reliable technical approach calibrate field sensor used investigation core losses electrical machine drop actual field value proposed approach based developing circuit consists two test array effect sensors used study reference field calibration results show magnetic field strength measured specimen surface coil scaled actual field results verified experimentally validated finite element simulations based obtained results correction factor applied rotational core losses attain accurate data
flexible universal domain decomposition parallel scheme proposed stable finite difference time domain method alternating direction implicit method employed eliminate restriction lewy stability condition proposed domain decomposition parallel implementation method flexible process allocation requires fewer data communications buffer region introduced interactions neighboring time step electromagnetic simulations presented demonstrate applicability accuracy efficiency proposed method
childrens influenced several factors memory age social main objective study analyze factors associated degree year old year old year old children measure new scale based scale developed results showed younger children older children higher degree social associated stronger responses smaller memory span related greater childrens conclusions highlight memory social analyzed carefully accounts children considered
last decade based projects significant attention solution various social economic environmental problems popularity different discourses real perceived scientific non scientific literature discourses positioned crop helpful producing protecting sustainability reducing greenhouse gas emissions compared fossil fuels increasing local rural development creating jobs consequently many countries established national policies establishment crop paper explore case development mexico argue popular discourse around sustainability rural development tool analyzing results semi structured interviews community members belonging region scale projects introduced found projects many significant social sustainability benefits conclude case just adding projects help achieve social sustainability rural areas alone ensuring social sustainability projects future processes comprehensive understanding rural socioeconomic problems projects promoted use projects one many solutions local problems rather creating policies based just popular discourses
growing amount evidence suggests magnesium deficiency play important role several clinical conditions concerning women health syndrome postmenopausal symptoms number studies highlighted positive correlation magnesium administration relief prevention symptoms thus suggesting magnesium supplementation represent viable treatment conditions despite amount evidence describing efficacy magnesium data available pharmacological mechanism ion conditions herein review available evidence use oral magnesium supplementation several conditions discuss pharmacological mechanisms characterize interventions picture emerges indicates magnesium supplementation effective prevention syndrome menstrual migraine prevention symptoms
lng natural gas process source cold exergy suitable recovered improve efficiency thermal power plants paper innovative power plant lng natural gas exergy utilisation capture gases presented characterised recovery lng cold exergy closed cycle direct expansion coupled electrical generator moreover novel power plant configuration allows capture fuel combustion system rankine cycle operates gases quasi critical conditions greatest advantage plant lng exergy used increase efficiency closed cycle direct expansion whereas power cycles found literature associate lng capture part lng exergy used gas subsequent capture result high efficiency power plant achieved exceeding almost zero greenhouse gas emissions elsevier ltd rights reserved
new tri substituted derivatives exhibiting aggregation induced emission synthesized synthetic route including catalyzed coupling reactions results evaluation thermal optical electrochemical photo physical charge properties synthesized derivatives presented compounds possess high thermal weight loss temperatures exceeding degrees synthesized compounds form glass transition temperature ranging degrees maximum fluorescence intensity wavelengths range highest quantum yield observed solid sample phenyl electron spectra films synthesized compounds revealed ionization potentials hole drift layers para substituted tri reached moderate electric fields established time flight technique
water pollution organic materials metals one problems threaten nowadays next decades morphological changes fish liver also represent adaptation strategies maintain physiological functions assess acute chronic exposure chemicals found water sediments paper presents automatic system assessing water quality egypt based microscopic images fish liver proposed system used fish liver hybrid biomarker order detect water pollution utilized case based reasoning indicating degree water quality based different histopathological changes fish liver microscopic images various performance evaluation metrics namely retrieval accuracy receiver operating characteristic roc curves measure mean used order objectively indicate true performance system considering unbalanced data experimental results showed proposed hybrid biomarker based system achieved water quality prediction accuracy using cosine distance similarity measure also outperformed classifiers tested microscopic images dataset elsevier rights reserved
study objectives many sleep disorders characterized increased motor activity sleep contrast studies motor activity physiological sleep largely lacking quantitatively investigated large range motor phenomena physiological sleep design prospective investigation setting academic referral sleep laboratory participants one hundred healthy age strictly selected representative population sample two step screening procedure interventions measurements results according american academy sleep medicine standards performed quantitative normative values established periodic limb movements sleep high frequency leg movements neck rapid eye movement related activity thirty six subjects index index percentile thirty three subjects percentile four sequences night subjects percentile sleep nine subjects fulfilled criteria excessive thirty five subjects percentile sleep sleep different activity measures muscles calculated percentile activity sec according recommendation activity twenty five subjects exceeded recently proposed cutoff none subjects exceeded cutoff conclusion quantification motor phenomena basic prerequisite develop normative values first step toward precise description various motor phenomena present sleep rates motor events unexpectedly high even physiological sleep future use normative values research clinical routine essential
study effects mir proliferation apoptosis cell line explore potential molecular mechanism mir regulates biological process real time polymerase chain reaction qpcr performed explore mirna level mir cell line infected mir mimics establishment mir overexpression non infected cells group cells infected empty vector served negative control group mtt assay conducted measure cell viability cell cycle apoptosis explored using flow cytometry apoptosis related markers detected western blotting qpcr results revealed mir mirna level cells significantly lower osteoblasts mtt assay showed cells infected mir mimics exhibited markedly decreased proliferation ability compared empty vector groups next found overexpression mir remarkably increased apoptosis cells evidenced flow cytometry results elevated bax reduced bcl furthermore results revealed percentage cells phase mir mimic group significantly higher groups mir attenuated proliferation induced apoptosis cells via promoting cell cycle arrest thus mir potential novel therapeutic treatment
effects exposure violent video games automatic associations self investigated sample students playing violent video game led participants associate aggressive traits actions implicit association test addition self reported prior exposure violent video games predicted automatic aggressive self concept beyond self reported aggression results suggest playing violent video games lead automatic learning aggressive self views association professionals services adolescents published elsevier ltd rights reserved
health professionals working young children need aware potential child abuse cause physical injuries fractures clinical experience serious case reviews research show maltreatment kept mind order investigations carried appropriate prevent harm whilst accidental fractures common fractures also injury professionals possibility child abuse presenting clinically detected injury imaging reasons investigating case suspected maltreatment health professional evaluating child fracture aware features raise suspicion abuse cause familiar current recommendations investigations article outlines current research concerning abusive fractures children offers guidance optimize radiological investigations avoid common pitfalls clinical practice
assess liver stiffness using ultrasound point shear wave children operation eighteen children undergoing operation prospectively enrolled eight measurements obtained right hepatic lobe surgery multiple postoperative time points temporally related inferior pressure data collected medical records available changes mean liver shear wave speed assessed using mixed effect model post hoc correction changes pressure evaluated using wilcoxon signed rank test value less considered significant mean age months baseline mean liver normal increased days days five subjects returned mean days mean liver remained elevated mean pressure increased mmhg baseline mmhg days post surgery operation immediately chronically increases liver stiffness pressure study provides evidence congestion key driver associated liver disease cent operation triggers immediate hepatic congestion marked liver cent congestion fibrosis drives early increased liver stiffness patients cent hepatic congestion persists chronically months operation cent congestion shear wave post liver fibrosis biomarker
despite great advances treatment acute leukemia current chemotherapy needs improved present study underlying mechanism new synthetic derivative acute leukemia potential anticancer effect drug resistant cells caused arrest ultimately led apoptosis demonstrated novel microtubule agent effects oral administration showed relative potent anti leukemia activity vivo xenograft model investigation revealed triggered induction arrest followed mitochondrial membrane potential loss cleavage activation jun terminal kinase addition enhanced cytotoxicity resistant acute cells inhibition akt mtor pathway protein expression also active glycoprotein overexpressing national cancer institute resistant cells little susceptibility taken together potential oral drug adjunct treatment drug resistant cancer cells
project healthy choices self administered based prevention intervention developed women risk alcohol exposed pregnancy participants sent assessment study materials united states service article uses data larger study focuses women identified hispanic potential participants called response english spanish ads said read write spanish given choice receiving intervention materials english spanish main objective present study evaluate differences outcomes function language intervention materials received participants levels prior study women risk month follow two thirds hispanic women reduced overall risk primarily practicing effective birth control outcomes similar reported previous project choices studies significantly women requested intervention materials english compared spanish reduced overall risk women high english cultural domain scores significantly less risk due effective contraception reduced overall risk compared project choices studies project healthy choices less intensive self administered freely available completed without visiting health care practitioner clinic
examine degree party leaders dominate parties time across countries analyse leadership relates formal aspects party organisation moreover analyse whether leadership increasing membership explain change leadership purpose use new dataset brings together different sources party data time countries find leadership indeed increased time still lot variation exists parties also demonstrate example members party leader increasing membership leadership words leadership work
administration day one month young active affected urinary excretion creatinine acid blood levels vitamin divided four groups according amount found urine vitamin determined blood changes vitamin mutually reciprocal group utilized donor one two carbon units means vitamin different metabolic pathways men administration accompanied increase level blood last man discovered level dropped differences initial terminal levels indicate affects redox processes creatinine excretion urine changed dependence extent metabolic disturbances
esterase gene expressed escherichia coli active recombinant secreted using host expression expression vector applied gene cloned terminal mating factor pre pro sequence expressed control methanol inducible alcohol oxidase purified homogeneity using ion exchange hydrophobic interaction chromatography recombinant showed degrees released acid esters natural substrate wheat substrate specificity profile descriptor based analysis demonstrated unique properties showing fit current classification model synthesis esters proven mono international union biochemistry molecular biology inc volume number pages
previous studies reported translation effect memory whereby encoding tasks involve translating processing domains produce memory advantage relative tasks involve single domain investigated effects translation true false memories using deese roediger mcdermott drm procedure deese prediction occurrence particular verbal immediate recall journal experimental psychology roediger iii mcdermott creating false memories remembering words presented lists journal experimental psychology learning memory cognition translation modalities enhanced correct recognition effect false recognition results consistent previous research showing correct memory enhanced cost terms accuracy findings discussed terms understanding relationship true false memories produced drm procedure
article outlines emergence aba applied behaviour analysis mid century current popularity aba world draw work earlier highlight role influential practitioner aba argue reception initial work mainly positive despite concerns regarding efficacy use physical work however accepted medical practitioners published results many accepted results validation research though methods broader understanding autism shifted considerably since early work article analyses controversies surrounding aba since early considering particular made autistic people movement earlier use painful exemplified campaign use shock therapy judge center unlike earlier non autistic however many movement reject ideological goals aba considering autism neurological difference rather pathology argue eliminating benign autistic behaviour aba owing individual psychological harm wider societal impact finally compare claims made movement made similar century social movements
doppler high pulse repetition frequency susceptible range clouds distant targets large range degrade quality wind profiles calculated retrieved variables technique detect remove range folded returns moment observations proposed described simplified method removing erroneous wind observations range folded returns also detailed detection removal range folded quality accuracy wind profiles shown improve
memory increasingly understood source vulnerability resilience within experience disasters associated natural hazards article investigate members populations impacted disasters australia new zealand forms memory tied minority identity gay men along sexual gender minority groups experience increased vulnerability disaster contexts resulting discrimination draw interviews two gay men lived crisis hiv aids beginning recently seriously impacted disaster associated natural hazard memories hiv aids informed mens experiences later disaster ways resilience conversely resulted feelings vulnerability isolation
complex paediatric neurology patients generally present non specific symptoms developmental delay impaired movement epilepsy diagnostic trajectory disorders usually complicated long lasting patients parents additionally caring chronically child stressful demanding parents patients experience impaired health related quality life hrqol study aims assess parental hrqol factors related physical mental hrqol parents measured compared general population using questionnaire parents also completed questionnaire measurement patient hrqol additional questionnaires used measure parental uncertainty visual analogue scale worry phenomena state worry questionnaire obtain socio demographic data linear mixed model random effect used investigate variables associated parental hrqol compared general population hrqol parents appeared diminished fathers showed lowered physical mental hrqol whereas mothers showed diminished mental hrqol patient hrqol parental worry phenomena significantly correlated overall mental parental hrqol reduction parental mental hrqol also children strongly rely parents parental mental health known influence childrens health awareness problems among clinicians supportive care needed important prevent exacerbation problems european paediatric neurology society published elsevier ltd rights reserved
study sought determine features ideal serve mens professional total first serves executed male players australian open competition classified either returned play spatiotemporal impact location speed projection angles landing location relative player locations contextual score features serve extracted eye data used construct classification tree model decision rules predicted serve outcome means clustering applied landing locations quantify optimal landing locations classification tree revealed serve relative landing proximity nearest service box line serve speed classified accuracy appeared contingent accuracy speed serves directed degrees landing service box line indicative ace means clustering revealed four distinct locations approximate deep service box corresponded landing locations provide empirically derived target locations players adhere practice competition
economic relations modern enterprises important factor modern enterprise management manufacturing engineering mainly carried contract effectiveness contract foreign construction enterprises entering china market advantages powerful technology management chinas construction enterprises exert enormous pressure impact meanwhile construction enterprises order enter international market international competition without high level contract management reason chinas construction enterprises attention contract management improve awareness employees contract contract management business management allowed operate freely according law accelerate development construction enterprises china
interleukin pleiotropic regulatory cytokine potential treating several human diseases including type diabetes thus far conventional expression systems recombinant production proven difficult limited efficiency study transgenic plants used novel expression platform production human dna constructs containing cdna introduced tobacco plants transcriptional expression gene transgenic plants confirmed reverse transcriptase polymerase chain reaction northern blotting western blot analysis showed protein efficiently accumulated transgenic plants present multiple molecular forms expression level high total soluble protein leaves multiple forms plant derived recombinant result differential linked glycosylation revealed enzymatic chemical linked vitro digestion indicated plant resistant control stability plant digestion supported simulated gastric intestinal fluid digestion vitro using factor dependent human cell line cells showed plant retained biological functions authentic protein results demonstrate transgenic plants superior conventional cell based expression systems production moreover transgenic plants synthesizing high levels prove attractive delivery system direct oral administration treatment clinical diseases type diabetes
multimodal actuator proposed fulfil different walking patterns power assisted knee actuator leg realize several modes operation including series elastic actuation position control energy storage release energy amplification characteristics multimodal actuator series elastic mode analysed dynamics model established study series elasticity equivalent mass transmission influence power source electric motor results simulation experiment show series elasticity amplify actuator power output power output multi modal actuator greater equivalent mass transmission mechanism smaller research multimodal actuator energy amplification supplies important insights design artificial systems closely approximate performance biological systems
application fuzzy rule interpolation making intelligent systems viable many areas however requirements systems change time supporting static rule base able provide accurate interpolation results long run dynamic fuzzy rule interpolation one potential solutions problem developed last years fulfil requirements dynamic pertinent rule bases intelligent systems nevertheless applications proposed approach need investigation one potential application network security one biggest concerns organisation irrespective size nature business intrusion detection systems considered one popular effective security tools generating systems network administrators inform possible existing threats standard ids effective even unsuitable organisational individuals requirements paper presents application building effective ids implementation popular open source ids used resultant intelligent ids named experimental analysis shows integration ids provides additional level intelligence predict level sensitivity possible threats also provides dynamic rule base promoting new rules based current network traffic conditions helps reduce false positives false
since molecular biology studies began researches biological science centered proteins genes molecular level single cell cancer research also focused various functions proteins genes distinguish cancer cells normal cells accordingly contemporary anticancer drugs developed target abnormal characteristics cancer cells despite great advances development anticancer drugs vast majority patients advanced cancer shown prognosis high rate relapse resolve problem focuses current cancer research cancer considered systemic disease cancer cells undergo complex interaction various surrounding cells cancer tissue spread whole body metastasis control systemic modulation human body relies cooperative interaction various tissues organs organ performs specialized function tissue specific cell networks therefore investigation tumor specific cell networks provide novel strategy overcome limitation current cancer research review presents limitations current cancer research emphasizing necessity studying tissue specific cell network new perspective treating cancer disease cancer cells
propose new class distributed heterogeneous systems systems task wait result another task either locally remotely wait dependencies instruction propose host based precise method recover wait causes across machines using blocking fundamental mechanism detect changes control flow relies solely operating system events namely scheduling network events therefore capable observing kernel threads interactions achieves user space runtime independence given task algorithm computes active path trace presented interactive inspection validated new method workloads representing major architecture operating conditions found distributed programs used method analyze execution behavior five different distributed systems found worst case tracing overhead distributed application percent typical average overhead percent analysis implementation linear runtime according trace size
one class classification belongs one novel promising topics contemporary machine learning recent years ensemble approaches gained significant attention due increasing robustness unknown outliers reducing complexity learning process previous works proposed highly efficient one class classifier ensemble based input data clustering training weighted one class classifiers clustered subsets however main drawback approach difficult time consuming selection number competence areas indirectly affects number members ensemble paper investigate ten different methodologies automatic determination optimal number competence areas proposed ensemble roots model selection clustering also effectively applied classification task order select useful technique investigate performance number one class multi class problems numerous experimental results statistical testing allows propose efficient fully automatic method tuning one class clustering based
background utilities disability weights metrics used calculating quality adjusted life years disability adjusted life years respectively utilities obtained multi attribute instruments dimensions questionnaire proposed set health states respectively objective study develop approach mapping utilities existing allowing predict new based utilities methods conducted two pilot studies including respectively four twenty seven health states selected study first study participant evaluated four health conditions using standard written questionnaire second study participant evaluated four health conditions randomly selected among twenty seven health states using previously developed web based questionnaire responses translated utilities using model developed regression allowed map utilities transformed results overall respondents completed first second survey respectively first study monotonic relationship derived utilities predicted observed second study important differences ranking health states based utilities versus participants current study attributed relatively higher severity level musculoskeletal disorders legs relatively lower severity level non functional disorders headache migraine compared participants studies conclusion study suggests possibility translate utility derived scores also highlights important observed satisfactory result methodology utilities derived population public health students written questionnaire small number health states presence study leader however results unsatisfactory utilities derived sample general population using web based questionnaire recommend repeat study larger diverse sample obtain representative distribution educational level age
introduction obesity serious public health problem mexico national health nutrition survey reported prevalence overweight obesity children aged recent research suggested gut microbiota risk factor obesity influence human metabolism aim study evaluate association intestinal microbiota profile obesity among children whether association modified depending feeding pattern sample mexico city results cross sectional study children aged years physical activity questionnaire personal medical history obesity type diabetes administered children eating patterns performed principal component analysis pca association intestinal microbiota overweight obesity depending diet assessed logistic regression models conclusion results shows interaction intestinal microbiota diet particularly high simple carbohydrates increases chance developing obesity
background numerous surgical options exist treat lesions knee including transplantation first generation autologous implantation next generation purpose compare cost effectiveness secondary purpose study compare functional outcomes study design systematic review level evidence methods two independent reviewers conducted online literature search databases level studies using international knee documentation committee knee injury osteoarthritis outcome score hospital special surgery knee score weighted mean difference pre postoperative functional outcome score calculated treatment mean per patient costs associated determined recent publication based review national private insurance database cost procedure divided weighted mean difference functional outcome score give cost per point change outcome score results total studies level level met inclusion criteria functional outcome analysis including mean follow significantly different groups months months months months mean increase functional outcome score change functional outcome score significantly greater compared treatments cost per point change functional outcome score conclusion effective surgical procedures treatment cartilage defects knee treatments led increase functional outcome scores postoperatively short term follow statistically greater improvement functional outcome scores compared procedures found cost effective treatment option least cost effective
measurements along atomic force microscopy ray diffraction residual stress analyses basis raman measurements performed characterize stress tailored thin films grown using reactive intrinsic stress gradient caused growing plane grain size along film thickness minimized increasing concentration gas mixture growth process increase concentration degrade device relevant material properties orientation surface morphology piezoelectric response modulus due comparable film properties investigated samples concluded mainly contribute mechanical film properties modulus hardness film stress grain boundaries minor influence therefore tailoring stress gradient films device performance fabrication yield design flexibility electro acoustic devices greatly improved elsevier rights reserved
sheep offers unique mammalian model study paradoxical sex sexual partner preferences variations sexual partner preferences occur spontaneously many population exhibiting sexual preference male oriented current review presents overview update male oriented ram model discusses several theories explain sex preferences species although understanding biological determinants underlying neural substrates sexual attraction selection far complete compelling evidence discussed supports idea neural substrates regulating sexual partner preferences organized prenatal development challenge future research construct integrated picture hormones genes experience shape sexual partner preference elsevier inc rights reserved
aim assess usefulness spectral data detect structural physiological changes crops water saline stress images acquired fixed wing unmanned aerial vehicle uav concomitant measurements gas exchange plant water status leaf structural traits chlorophyll taken commercial farm located southeast spain two species irrigated eight years saline water combined regulated deficit irrigation measurements leaf scale airborne carried twice day irrigation decreased gas exchange leaf dry mass per unit area however salinity resulted increase pressure potential allowed maintaining net photosynthesis conductance pressure deficit increased crops leaf total chlorophyll concentrations significantly reduced moreover decreased stem water potential psi independently water quality regarding spectral data red wavelength significantly correlated except subjected stressful climatic conditions since influenced addition plant water gas exchange status near infrared nir useful indicator psi crops normalized difference vegetation index clearly related gas exchange species psi finally combined data species best indicators nir novelty study show diurnal changes physiological structural traits irrigated combined determined images elsevier rights reserved
advances clinical immunology past year included report practice parameters diagnosis management primary guide clinician approach relatively uncommon disorders learned new gene defects causing immunodeficiency new phenotypes expanding spectrum conditions caused genetic mutations specific regulator telomere elongation mutation causing isolated natural killer cell deficiency mutations ras associated resulting immunodeficiency without advances diagnosis included increasing use whole exome sequencing identify gene defects measurement serum free light chains identify secondary several primary improved outcomes reported definitive therapy hematopoietic stem cell transplantation gene therapy
oxidative stress thought involved development parkinsons disease previously reported compound isolated possesses properties depth molecular mechanisms induced neurotoxicity remains unknown recent studies indicate without intact nuclear factor erythroid related factor protein becomes unstable activity mediated downstream antioxidant enzymes thereby suppressed study showed clearly protected cells induced oxidative injury furthermore markedly regulated levels turn activated kinase akt signaling inhibited glycogen synthase kinase beta beta activation eventually promoted nuclear translocation induced expression antioxidant effects partially blocked mediated knockdown inhibition akt pathways kinase inhibitor respectively findings confirm necessary mediated protection induced oxidative damage least part activating akt signaling subsequently enhancing nuclear accumulation findings investigation suggest developed novel candidate alleviating consequences future elsevier rights reserved
gene par prostate apoptosis response originally identified prostate cancer cells undergoing apoptosis product par showed cancer specific activity particularly domain par par selectively cancer cells leaving normal cells unaffected therapeutic significance bioactive par enormous cancer biology however large scale production still matter concern report production par gfp fusion protein coupled translational enhancer sequence signal peptide atp transgenic plants control unique recombinant promoter transgene integration confirmed genomic dna pcr southern northern blotting real time pcr nuclear run assays results western blot analysis elisa confirmed expression recombinant gfp protein high total soluble protein addition found targeting plant recombinant par gfp endoplasmic reticulum essential stability plant recombinant protein comparison bacterial derived par analysis demonstrated targeted par gfp undergoes linked glycosylation unlike targeted par gfp furthermore various vitro studies like mammalian cells proliferation assay apoptosis induction assays suppression suggested cytotoxic apoptotic properties plant derived par gfp multiple prostate cancer cell lines additionally pre treatment prostate cancer cells purified par gfp significantly delayed onset tumor rat prostate cancer model taken altogether plant made par become useful alternate therapy effectively alleviating cancer new era
letter novel pass network implementation proposed using distributed lumped elements high group delay implementation reduced footprint sensitivity group delay performance specified component value experimentally verified measured group delay ghz reported approaches circuit finds varied applications high resolution analog signal processing
equal access autism services remains suboptimal diverse groups canada little known barriers immigrant mothers face accessing services support children developmental disabilities qualitative study immigrant mothers children autism diverse cultural background interviewed canada apply houses four domains social support analyze findings structural support challenges delays diagnosis fragmented dispersed services common followed instrumental challenges due loss social stigma lack expected support partners negative perceptions services identified emotional challenges focused attention required address inequalities within context current access pathways autism
reservoir located river basin belt reservoir receives acid mine drainage river river two multi parameter probes one placed tail gradient end reservoir contaminants enter another close reservoir dam used characterize migration reservoir probes measured conductivity every min two different levels contamination found due dilution takes place within reservoir changes composition cross correlation function allowed quantification migration process tail dam conductivity maximum correlation occurred days sampling indicating mean transit time days since distance two sampling points contaminant transit speed
paper authors present energy production potential mechanically resonant electrical generator system makes use natural human walking movements characteristics associated human walk discussed first followed electromechanical modeling approach employed choice electromechanical architecture justified permanent magnet moving coil structure modeled optimized demonstration device also generated tested order validate concept developed theoretical models derived
background recommends solar vaccine storage areas less eight hours electricity per day guidelines conservative question remains solar provide value electrical less frequent methods using generated computational model routine immunization supply chain simulated use solar versus electric powered referred electric different locations supply chain various circumstances results current price annual cost solar electric district level health facilities solar provided savings electric one day electrical occurred five times per year either district level health facilities even electric time exceeded duration two day occurring three times per year district level twice per year health facilities also caused solar cost saving lowering annual cost solar electric allowed solar cost saving either level one day occurred per year two day occurred per year district level even per year health facilities conclusion study supports guidelines fact solar provide savings total cost per dose administered electrical electrical less frequent study identified frequency duration electrical need occur solar provide savings total cost per dose administered electric different solar prices published elsevier ltd
resonant converters used coil drivers inductive links generally operate efficiently optimum switching conditions constant load values ranges changes load range shift operation coil driver switching state results higher switching losses reduced output power levels paper presents method adapt variations range class inverter used coil driver wireless power transfer system based inductive coupling shown controlling duty cycle inverters switch value feed inductance class inverter tuned operate optimum switching conditions distance coils system changes mathematical analysis presented based linear piecewise state space representation inverter inductive link extensive experimental results presented verify performed analysis validity proposed tuning procedure
objective recognizing state art regarding care skin newborns method integrative literature review search studies performed medline databases studies published selected results indicated variety orientations used health professionals care skin newborns frequently addressed topics causes lesions nursing care prevention lesions appropriate handling newborn infant assessment skin prevention water loss body temperature regulation use bath fixation devices prevention pressure ulcers care measures toward treatment lesions conclusion study allowed updating subject enabling humanized individualized qualified care ensures safety neonatal patient
population growth urbanization pollution climate change pose urgent water challenges cities study sustainability integrated water resources management chi city evaluated using city approach city set dedicated indicators divided categories water security water quality drinking water infrastructure climate robustness biodiversity attractiveness governance including public participation analysis showed rapid increase water use urban industrial agricultural activities resulted depletion groundwater severe pollution groundwater surface water surface water quality groundwater quality biodiversity domestic industrial wastewater matters need serious improvement current future water supply risk cope governance gaps described organisation economic operation development major obstacles rainwater harvesting pollution reduction wastewater reuse among practical options wastewater reuse lower water stress index window narrow rapidly closing result unprecedented urbanization economic growth region assess
project hardware software architecture development implementation adaptable adaptive applications aimed support people carrying independent life home paper problems interactions applications implemented android platform chosen experiments interaction developed applications discussed main emphasis two main aspects use facilities supporting accessibility available commonly used operating systems portability solutions across different platforms
soils one problematic materials widely encountered significant land areas several parts world like africa australia india united states canada south region india majority top soil black cotton soil black cotton soil characteristics drying soil creates several types damages pavement structures cases pavement even become normal climate condition study area shows short wet long dry period problem swelling shrinkage suggest thick non cohesive soil soil road construction led higher cost road construction also new urban areas difficult raise depth due existing structures service lines provide economical solution along feasible application two innovative materials used namely geotextile flexible pavement application shows great improvement values helping overall stability pavement geotextile provided pavement components act swelling soil time helps drainage layer also field study undertaken observe effect geotextile flexible pavement performance specific boundary conditions created observations observations shows reduction shrinkage effect road reinforced geotextile subjected drying cycles materials unique advantage performance improvement flexible pavement
purpose review contraception highly effective form birth control globally popular recent research focused ways make acetate accessible improve side effect profile review focus new directions approaches use contraception recent findings research area contraception focused improving access women home self injection also task shifting community based distribution low resource areas specific studies focused lowering overall dose medication maintaining efficacy improving drug delivery systems research association hiv needed also effects administration time medication abortion summary contraceptives important part global method mix highly effective birth control improving accessibility side effect profile make even valuable women seeking effective contraception
paper introduces basic concept fuzzy pid manufacturing engineering system temperature control analyzed temperature designed correction factor optimized parameters application fuzzy general matlab simulink toolbox temperature designed comparing fuzzy pid output output system characteristic quick response short setting time small high control precision
distributed denial service attacks always remain problematic security data centers malicious codes injected weaker network acquire access protection initial line defense access help transactions conventional rely predefined policies control policies rely assumptions notions much intelligent take run time decision last minute required however continuously stroke port responding moreover chance access servers entire network survey based state art data centers especially challenges paper based learning processes focus evaluate analyse complexity secure connections real world data centers
objective evaluate knowledge caregivers identification changes skin elderly care consider correct situations methods descriptive study caregivers patients treated university hospital federal district used pre post test questions type cause treatment common skin disorders elderly results sample caregivers women average age years old children elderly reported course caregiver pre test damage recognized area dermatitis post test improvement recognition items correct answers conclusion results showed injuries known caregivers part day day care elderly easy recognized educational guidance carried becomes effective method identify lesions
conjugated poly denoted synthesized catalyzed cross coupling used novel organic semiconductor photocatalyst photocatalytic production pollutant degradation visible light lambda irradiation furthermore conveniently fabricated situ procedure presence commercial optimizing composition ratio resultant exhibited dramatically enhanced visible light responsive photocatalytic activities similar times higher activity evolution degradation respectively compared alone detailed investigations revealed interface accelerate electron transferring improve present work exhibits interesting points dramatic improvement organic semiconductor combined inorganic one provides novel direction exploit fabricate photocatalyst solar energy conversion pollutant degradation elsevier rights reserved
background objective acute respiratory failure patients interstitial lung disease ild associated significant morbidity mortality recommended assessment acute exacerbation ild includes exclusion secondary causes via aim assess role ild methods consecutive ild patients hospitalized underwent included baseline demographics underlying ild diagnoses presenting clinical features reviewed characteristics including diagnostic findings management complications results one hundred six patients accounted unique sixteen abnormal infections baseline presenting clinical features differ without abnormal findings half performed intensive care unit icu performed general floor setting resulting icu transfer resulted immediate mechanical ventilation overall management positive findings similar without resulting similar hospital mortality conclusion clinical assessment ild often performed yield large retrospective cohort management mortality similar routine diagnostic ild studied given low yield high procedural risk
sex useful creating beneficial traits however resultant decrease genetic relatedness potentially detrimental interactions fungus growing cultivated fungi genus host try increase intra relatedness increase crop productivity parasites fungi sub genus also use sex generate variation counter evolving host defensive mechanisms using molecular phylogenetic tools found within genetic homogeneity species species associated fungus growing lower higher genotypic diversity within abundant genus sub genus additionally population genetics methods suggest sexual population structure species clonal propagation species first study investigate population genetics symbiotic fungi associated genus india elsevier ltd british society rights reserved
widely used species identification dairy products focusing para kappa peptide used official german method differentiation isoform isoform dairy products based different points discrimination dairy products using however shown problematic existence isoform milk indigenous dairy due nucleotide polymorphisms within kappa gene indigenous alter point para kappa peptide lead false positive results previous dna analysis kappa gene shown high levels polymorphism however information available indigenous dairy therefore indigenous dairy sequenced exon kappa total polymorphic sites detected three point mutations identified change point para kappa peptide appears identical peptide ten composite genotypes reconstructed included problematic point mutations verification genetic results carried patterns appeared problematic genotypes frequency genotypes characterized moderate high within indigenous however issue restricted greece genotypes detected various non conclusion based official german method certainly inappropriate discrimination concerning dairy products consequently new method established
determination partial discharges inception voltage different configurations electrical motors essential ensure sizing choose right electrical insulation system standard ieee suggests using measurements performed model show good reproducibility results non also done using law modified resulting experimental measurements good accordance obtained modeling
complex mitochondrial serine protease regulates critical biological functions diseases including apoptosis cancer promising therapeutic target promotes apoptosis multiple pathways complex mechanisms still elusive existing model activation emphasizes relative movements terminal protease domains protease collapse inactive resting states able demonstrate dynamics actions using structure guided design molecular biology protein biochemistry obtained various combinations domains mutants conformational changes stability characterized using molecular dynamics simulation spectroscopic tools functional enzymology delineated roles regulating enzyme catalysis quantitative resonance energy transfer showed lesser protease distance compared inactive counterpart approximate approximate respectively degrees findings highlight importance terminal region intricate protease interaction proper active site formation enzyme substrate complex stabilization hence functions observations existing activation model unique example precise coordination plasticity contacts lead distinct functional properties hence provide new insights structure function dynamics
two bacterial strains isolated root nodules soybean characterized members distinct group genus based rrna gene comparisons also verified separated group sequence analyses similarities type strains defined species average nucleotide identities whole genome sequence representative strain closely related strains respectively phylogeny symbiotic genes grouped two strains together soybean strains tests indicated representative strain form root nodules capability nitrogen host plant glycine vulgaris formed ineffective nodules strain contained fatty acids omega iso differing related strains utilization threonine serine carbon source growth intolerance distinguished strain type strains related species genome size comprising predicted genes dna content mol unique genes therefore novel species proposed type strain elsevier gmbh rights reserved
background river basin province place origin river study gives comprehensive analysis vegetation coverage region provides potential theoretical basis ecological restoration methods seasonal variation vegetation dynamics based normalized difference vegetation index major land cover types region studied analyzing relationship temperature rainfall derived set predictor variables using modis level product results results showed general increasing trend value region region showed degradation values begin rise april plants drop september temperature decreasing leaves falling study area temperature found decreasing period rainfall showed increasing trend model used observe change vegetation dynamic effects temperature rainfall conclusion study provided important data environmental protection basin area hope provide scientific analysis controlling water soil erosion maintaining sustainable productivity land resources enhancing treatment water pollution stimulating cycle ecological system
configuration realization voltage mode second order filters employing single operational amplifier active element presented topology synthesize notch filtering functions presented filters suitable mos implementation yielding filter parameters electronically tunable theoretical analysis verified pspice simulation elsevier gmbh rights reserved
paper math theory used random restrictions reveal weakness boolean circuits bounded depth establishing constant depth polynomial size circuits compute parity function local restrictions played important roles found many applications complexity analysis algorithm design past three decades article give brief overview two intriguing applications local restrictions first one second one moderately exponential time algorithms boolean formula problem
pest insect cultivated corn cotton across control remains challenging owing evolution resistance chemical transgenic toxins yet genomic resources remain scarce species bacterial artificial chromosome library mean genomic insert size created laboratory strain provides similar fold coverage flow cytometry estimated genome size assembly illumina reads generated pools clones resulted genomic total long terminal repeat protein coding regions annotated included elements encoded five functional domains approximately elements distributed non randomly across pools clones
paper deals identification nonlinear vibration systems based measured signals free forced vibration regimes two categories time domain signal analyzed one fast inter modulation signal second composed several mono components extent attempts analytic studies systems two major analysis groups perturbation harmonic balance methods two appropriate signal processing methods investigated one based signal decomposition hilbert transform shown enable effective simple methods analysis show precise identification nonlinear parameters obtained contrary average based methods approximation parameters obtained effectiveness proposed methods demonstrated precise nonlinear system identification using signal signal decomposition methods following tools used signal decomposition applied classical examples nonlinear systems cases nonlinear stiffness damping forces analyzed include among asymmetric oscillator nonlinear turbulent square friction oscillator dry friction elsevier ltd rights reserved
article generalised nonlinear schrodinger maxwell system investigated describes propagation optical solitons optical fibre doped two level resonant like fourth order dispersion taken account bilinear forms derived via hirota method symbolic computation auxiliary function bright solitons obtained complex envelope field measure resonant medium dark ones deduced extant population inversion propagation one two solitons analysed results solitons keep shapes unchanged interaction except phase shifts means interaction elastic velocities solitons decrease effect higher order dispersion increases bound state solitons formed among solitons velocity period decreases effect higher order dispersion increases
rationale little known residence rural farming environment allergic diseases latin america methods cross sectional study rural residence current current asthma current symptoms allergic adolescents ages years attending schools urban rural areas san rural residence classified never previous current duration rural residence categorized years current current asthma current allergic defined basis responses extensively validated questionnaire international study asthma allergies childhood logistic regression used multivariable analysis rural residence outcomes interest results adjustment current smoking covariates current rural residence odds ratio confidence interval rural residence years significantly associated reduced odds current multivariable analysis current residence rural area rural residence years significantly associated reduced odds allergic association longer significant additional adjustment current residence dairy farm significantly associated reduced odds allergic similarly current regular contact farm animals significantly associated reduced odds allergic conclusions among adolescents current rural residence rural residence years associated reduced odds current allergic potential protective effects explained dairy farm environment including regular contact farm animals wiley periodicals inc
growing number evidence suggests brain derived neurotrophic factor bdnf plays important part modulating activities basis hippocampus neural plasticity learning memory addiction series cognitive impairments associated bdnf study explored association bdnf cognitive function independent patients enrolled dependent patients normal control subjects examined cognition battery assessment neuropsychological status serum bdnf levels groups bdnf levels significantly higher patients controls cognitive scores showed attention language index significantly lower dependent patients control groups unfortunately found positive association bdnf cognitive function patients except bdnf positively associated visuospatial index control groups findings suggest bdnf involved pathophysiology dependence studies cognitive impairment addiction needed
although infrequent reactivation possible among patients hiv aids infection develop tumor like lesion cns report case years old male patient hiv aids low lymphocytes count cerebellar symptoms mild associated lesions positive tests empirical therapy prescribed together antiretroviral therapy without favorable response brain disease confirmed quantitative pcr csf died despite treatment despite rare occurrence disease affecting cns possible among patients hiv aids infection epidemiological exposure positive serological test image pattern brain lesions support suspicion diagnosis confirmed molecular test csf samples including new quantitative methods despite adverse prognosis specific therapy attempted besides antiretroviral treatment
summary united states united kingdom neglect children construction childhood children essentially vulnerable need constant care protection parents western conception transmitted countries sub via rights child however socio economic cultural context african countries differs significantly united kingdom united states incorporation western idea childhood national laws african countries creates fundamental application criteria adequacy parental supervision sub drawing secondary data article explores proposes alternative considerations assessment neglect finding combined effects households sub economic conditions ascribed gender roles reciprocal held children assist families established indicators thresholds neglect concept societal neglect together application matrix provides framework reducing risk significant harm children application african countries introduced rights child domestic legislation findings study pertinent policy makers social workers sub also western scholars critically engage dominant notions neglect applicability cross national contexts
paper deals synthesis active frequency filters oscillators applications video band synthesis based modified signal flow graph design approach current mode commercially available high frequency current second order structures used basic structure employing loss less current mode two distributed feedback loops used active elements allow control current gain useful applications high frequency multi functional filter electronically adjustable oscillator configurations discussed used passive elements mainly capacitors grounded suitable implementation simulation experimental results demonstrate function features
find balance food energy security research presents design energy self sufficient farm electricity heat produced energy crops agricultural residues farm proposed evaluated two models land optimization cost optimization due food fuel debate land food security research proposes utilizing current land increasing food self ratio crops analyzed rice wheat maize farm optimized several food fuel demands maximum farm unit size result myriad farms different sizes optimized certain demand subsequently amount variety farms optimized maximizing food fuel produced city case study japan results suggest establishment energy self sufficient farms land stimulate industry increase food security simultaneously maize wheat improved approximately respectively estimated potential additionally electricity heat approximately respectively obtained land optimization model proposed sensitive crop yields simultaneous evaluation recommended results also suggest farms larger achieve self therefore policies involved need evaluation
use polyacrylamide based become essential component geotextile tube projects although knowledge residual concentration geotextile tube effluent essential safe use based residual concentration commonly measured geotextile tube operations furthermore standard test method measuring residual concentrations water paper presents comparative study two different methods commonly used measure residual concentrations water streaming current detection method china clay settling rate method evaluate applicability geotextile tube industry comparison based analysis measured residual concentrations obtained five different cationic polymers used soil optimum doses soil determined using test three different solids concentrations mass methods performed supernatants conditioned optimum doses concentrations optimum dose laboratory test results showed methods produced similar residual concentration results polymer soil combinations tested method however produced consistent results comparison method method also easier use performed shorter amounts time method based results recommended method standardized used measure residual based concentrations geotextile tube effluent
present project possible prove relationship existing internal personality variables self concept pro distal variables like physical activity academic achievement within school context promoting physical activity sport also means teenagers learn personal social competence allows offer educational tool develop pro social behavior descriptive project whose sample made secondary school students socio demographic questionnaire used self concept questionnaire scale pro teenagers adults scale socialization difficulties soc different school among results obtained confirmed physical activity ones physical self concept improves turn leads better social perception thus integrating peer groups resulting better academic results
background negative mental imagery ubiquitous cognitive models social anxiety social anxiety literature previous research shown causal increased anxiety lower social performance ratings lower implicit self esteem despite prevalence studies investigated imagery directly aims study aimed provide depth analysis negative imagery experienced socially anxious individuals compare recurrent intrusive images images generated participants study method thirty eight undergraduate students screened average social anxiety scores completed computerized imagery questionnaire adapted previous qualitative work results thematic analyses revealed four major image themes intrusive images three generated images including interacting others anxiety symptoms intrusive images based negative episodic memories experienced least images primarily visual auditory somatic involve sensory modality depression anxiety stress scale scores higher participants experienced intrusive imagery increased frequency generally higher intrusive images generated images conclusions negative imagery experienced socially anxious individuals inherently different images generated use experimental research theoretical clinical implications discussed
ambient assisted living facilitate optimum health wellness physical mental social paper patients psychiatric symptoms collected lightweight biosensors web based psychiatric screening scales smart home environment analyzed machine learning algorithms provide ambient intelligence psychiatric emergency psychiatric states modeled hidden markov model model parameters estimated using path counting scalable stochastic variational inference based training algorithm likely psychiatric state sequence corresponding observation sequence determined emergency psychiatric state predicted proposed algorithm moreover enable personalized psychiatric emergency care service web objects based framework proposed smart home environment framework biosensor observations psychiatric rating scales web space web objects sensor observations psychiatric rating scores used assess mental health status predict emergency psychiatric state proposed psychiatric state prediction algorithm reported percent prediction accuracy empirical performance study
model driven engineering uses models various stages software engineering reduce cost modelling production models transforming therefore accuracy model transformations plays key role ensuring quality process however problems exist trying transform abstract content dependent model paper describes issues arising transformations solutions solve problems content based model transformation proposed usage proposed solutions allowing realization semi automatic transformations integrated tool designed xml drawing file transformations models accuracy transformations tool analyzed presented paper acquire data proposed solutions influence accuracy content based model transformation
previously many obese patients liver transplantation higher operative risk however nowadays years graft survival rule patients whose lives prolonged obesity related comorbidities recent experience suggests weight reduction liver transplant recipients improve long term survival bariatric surgery patients cirrhosis post transplant intervention associated increased technical difficulty present experience three patients underwent simultaneous liver transplantation median months follow patients normal allograft function significant weight loss combined liver transplantation simultaneous appears technically feasible relatively safe selected patients
statistics series ordinary least squares problems used study linear correlation among sets variables interest many studies number variables least millions corresponding datasets disk space availability large scale datasets increases regularly challenge dealing indeed traditional solvers rely use black box routines optimized one single highly inefficient fail provide viable solution big data analyses case study paper consider linear regression consisting two dimensional grids related problems arise context genome wide association analyses give careful development grid high performance routine shared memory architectures analogous steps relevant tailoring solvers applications particular first illustrate design efficient algorithms exploit structure problems eliminate redundant computations show effectively deal datasets fit main memory finally discuss cast computation terms efficient kernels achieve scalability importantly design decision along way justified simple performance models grid enables solution correlated problems operating data matter hours elsevier inc rights reserved
reliability system utilize reconstruction operations recover data disk fails however result longer recovery time negative impact system performances moreover possibility secondary failure increased recovery period paper proposed new reliability optimization method system active data migration called ram reserved space every disk data non sectors reserved space called internal disk data migration number bad sectors disk exceeds threshold disk poor reliability system copy data unreliable disk new one called external disk data migration process avoid data reconstruction dynamically adjust migration speed reduce impact front end performance load system requests user high priority overall results indicate ram improve reliability system little influence elsevier inc rights reserved
paper deals oscillating generators driven free piston engines original free piston engine oscillating rotary generator distinguishes minimum frictional losses full balanced mechanical system possibility four stroke operation internal combustion engine possibility multi fuel operation engine including possible version engine optimal magnetic circuit electrical generator etc engine optimally operate whole range output power enables improve electrical system hybrid vehicle usage instead battery way competitive hybrid electric vehicle electrical vehicle effective range created
sleep disturbance common parkinsons disease negatively impacts quality life little data dopamine agonists influence nocturnal sleep particularly sleep laboratory data measure sleep parameters changes objectively goal open label study objectively evaluate effect sleep patients video methods total patients complaints nocturnal sleep impairment enrolled sleep quality stable therapy evaluated questionnaire assessments objectively measured video methods depression anxiety quality life patients also evaluated questionnaire assessments end treatment daytime functioning motor performance depression subjective quality sleep quality life improved video analysis showed sleep efficiency stage increased sleep latency wake sleep onset periodic leg movements sleep index decreased treatment video analysis confirmed subjective improvement sleep treatment observation suggests treatment option patients sleep disturbances
big data consists huge volume complex growing data sets several independent sources rapid development data collection storage capacity big data expanding science engineering domains fundamental challenge big data applications large amount data extract required information knowledge future usage beyond limit relational databases respect storage processing massive quantity data intent paper considering big data repository dynamically mine recent related sons movie perform data mining operation analytics overcoming challenges categorized respect theorem handle massive amount used hadoop map reduce framework perform data mining analytic operations data data classification data clustering prediction model movie review built using naive bayes classifier accuracy prediction calculated help binomial test distribution clustering obtained basis location hash tags additionally privacy user preserved using data mining anomaly technique results displayed help intelligent graphs performance evaluation map reduce predictive analysis done using map reduce without using map reduce based execution time comparison performance graph obtained prove map reduce efficient framework huge volume data
background phenotypic data routinely used elucidate gene function organisms amenable genetic manipulation however previous work system place structured storage retrieval phenotypic information bacteria results ontology microbial phenotypes created capture phenotypic information microbes built foundations basic formal ontology phenotype trait ontology terms logical definitions facilitate computational searching phenotypes associated genes accessed via page downloaded initial annotations made escherichia coli using based annotation capture system new terms concurrently developed annotation proceeds conclusions anticipate diverse groups studying microbial genetics associated phenotypes employ microbial phenotype annotation much gene ontology standardized gene product annotation resulting resource associated annotations facilitate prediction phenotypes unknown genes result new experimental characterization phenotypes functions
project series electric sized small agricultural machinery developed tested electric drives noted benefits simplicity controllability integration electronics provide autonomous action efficiency wide operating range biggest drawback agricultural use limited capacity electrical energy storage series hybrid provides method overcome capacity constraints use chemical energy storage series hybrid research designed using established components consisted diesel electric generator lead acid battery pack motor controller independent electric motors wheel associated produce speeds torques suitable ground drive although components commercially available integrated hybrid goal project test determine baseline performance investigate efficiencies various components operating different conditions efficiency tested using factorial test factors average load level full load load profile type variable constant size battery pack efficiencies three main components monitored testing diesel electric generator battery system ground drive tested factors load level effect efficiency overall efficiency efficiency battery system system components impacted factors large battery necessary maintain efficiency even variable loads indicates future machines consider advanced expensive types batteries less capacity required agricultural engineers interested using electric motor drives various benefits use series hybrid design overcome energy storage limitations realize consistent efficiencies variety operating conditions
inner coastal waters heavily impacted human sewage pollution decades enteric viruses including human human group hepatitis virus likely found contaminated surface waters present work aimed assess frequency loads species sand water samples used summer attending event sixteen monthly collections carried march july different sites brazil total counting performed along molecular detection virus performed using quantitative polymerase chain reaction qpcr analyses samples investigated integrated cell culture pcr check presence infectious virus particles results show water samples showed contamination least one type virus regarding viruses individually water sand respectively viral loads ranged water sand phylogenetic tree classified four main clusters referring species sites studied presented least presence infectious contaminated points took place starting point demonstrating serious problem fecal contamination water resources health athletes residents elsevier rights reserved
objective telomeres regions ends chromosomes maintain chromosomal structural integrity genomic stability studies mainly older white populations shorter leukocyte telomere length associated cardiometabolic risk factors increased risks mortality coronary heart disease chd average african americans longer whites chd relationship unknown investigated relationship chd mortality among approach results using case cohort design postmenopausal women whites womens health initiative measured baseline blood samples southern blotting chd mortality hazards ratios estimated using race stratified risk factor adjusted cox proportional hazards models incident chd mortality events whites whereas experienced incident chd mortality events median follow years shorter associated older age current smoking white race ethnicity whites decrease associated increased hazard chd hazard ratio confidence interval association chd white women shorter higher risks mortality contrast shorter weakly associated decreased mortality hazard conclusions one largest prospective studies associations incident chd mortality diverse sample study suggests differences associations chd mortality white postmenopausal women
objective interventions required disproportionate tobacco related health burden experienced persons mental illness study aimed assess efficacy universal smoking cessation intervention initiated within acute psychiatric inpatient setting continued post discharge reducing smoking prevalence increasing quitting behaviours method randomised controlled trial undertaken across four psychiatric inpatient facilities australia participants randomised receive either usual care intervention comprising brief motivational interview self help material hospital followed month pharmacological psychosocial intervention upon discharge primary outcomes assessed months post discharge day point prevalence month prolonged smoking abstinence number secondary smoking related outcomes also assessed subgroup analyses conducted based psychiatric diagnosis baseline readiness quit nicotine dependence results seven day point prevalence abstinence higher intervention participants controls months post discharge odds ratio months respectively odds ratio significant intervention effects found measures prolonged abstinence either months post discharge differential intervention effects primary outcomes detected subgroups months post discharge intervention group participants significantly likely smoke fewer cigarettes per day reduced cigarette consumption made least one quit attempt relative controls conclusions universal smoking cessation treatment initiated inpatient psychiatry continued post discharge efficacious increasing day point prevalence smoking cessation rates related quitting behaviours months post discharge sustained effects quitting behaviour months research required identify strategies achieving longer term smoking cessation
telomeres somatic cells become shorter individual aging however significant change methylation somatic cells aging yet reported telomere lengths peripheral blood cells normal japanese analyzed southern blotting using methylation sensitive insensitive aging long telomeres decrease short telomeres increase contents telomeres methylated increase long telomeres thus leading telomeres less methylated tend become shortened faster telomere length distribution analysis methylation sensitive insensitive seems useful tool assess methylation status somatic cell population methylation peripheral blood cells also indicated indicator aging associated genomic changes
core flux switching permanent magnet machine large air gap delta medium speed application rpm presented general aspects machine design arising large air gap length machine discussed using finite element analysis found design rules conventional even alternate machines longer applied large air gap present particularly choice rotor poles investigated improve torque capability machine detail within machine design necessary reduce number rotor poles also beneficial reduction losses increased rotor speeds moreover height permanent magnets stator also need enlarged due large air gap machines prevent direct short circuit permanent magnet flux air gap additionally influence rotor torque variation briefly discussed
icc aggressive malignancy associated unfavorable prognosis effective treatments available molecular pathogenesis poorly understood genome wide sequencing high throughput technologies provided critical insights molecular basis icc heated debate cellular origin cancer exhibits origin progression cell biology recent evidence suggests icc multiple cellular origins including differentiated hepatocytes epithelial cells pluripotent stem cells hepatic stem progenitor cells tree stem progenitor cells gland however somatic mutagenesis features highly cell type specific multiple cellular origins profoundly different genomic landscapes key signaling pathways driving phenotypic variation thereby significant challenges personalized medicine terms achieving optimal drug response patient outcome considering information summarized latest experimental evidence relevant literature provide date view cellular origin icc contribute establishment hierarchical model carcinogenesis allow improvement anatomical based classification icc new insights important implications diagnosis treatment icc patients elsevier ireland ltd rights reserved
paper deals development signal conditioning circuit microcontroller compatibility capacitive sensors suitable wide range applications circuit comprises capacitive active bridge along relaxation oscillator converting capacitance changes frequency directly design analysis experimental results circuit application thin film based humidity sensor capacitive transducer measurement dielectric constant oil reported experimental results confirm theoretical values predicted frequency output circuit used determine response characteristics trace moisture sensor dielectric constants oils finally output frequency calibrated terms trace moisture parts per million ppm using commercial point meter accuracy moisture measurement using custom designed capacitive sensor full scale moisture range ppm compared point meter accuracy found nearly resolution ppm moisture circuit less complex easy integrate application specific integrated circuits standard cmos technology high sensitivity easily reproduced possible components achieving fairly good performance terms accuracy dynamic range
purpose uptake active surveillance changes prostate cancer care affect utilization complications following prostate needle biopsy characterized recent trends risk factors prostate needle biopsy complications using cohort materials methods used new york planning research cooperative system identify prostate needle biopsies performed via approach patients respectively characterized trends utilization complications using poisson regression cochrane test applied logistic regression examine predictors complications within days prostate needle biopsy results ambulatory use prostate needle biopsy decreased time common indication prostate needle biopsy elevated prostate specific antigen patients followed active surveillance cancer abnormal digital rectal examination prostate needle biopsy associated infection rate increased study period among repeat prostate needle biopsies complication rate comparable initial prostate needle biopsy rectal done less prostate needle biopsies multivariable analysis patient race procedure year diabetes approach recent hospitalization significantly associated infection median total charge infectious complications iqr conclusions across new york state infectious complications prostate needle biopsy increased time higher complications using approach minimal utilization targeted antibiotic prophylaxis efforts focus evaluation implementation strategies reduce post prostate needle biopsy complications nationally
within european countries example germany france high proportion students secure work part course opportunity develops students industry academia interactions comparison point universities recently regards preparing graduates employment difference raises question deficient within partnership models within effective relationship paper consider tactics overcome gap resulting operational challenges focusing particularly undergraduate course development case study used illustrate approach university manufacturing group development manufacturing engineering degree effective strategic partnerships require clear shared vision effective operational model develops lasting relationships set specific resources learning competencies shared vision university company produce work ready graduates graduates require extended graduate training scheme norm achievement vision required consideration physical environments communication operational challenges order create deeper level collaboration partnership result building institute academic research development based site new resource see learning environment students based allowing work live industrial projects reinforce taught theory semester long projects proposed company progress university subject specialists industrial workplace teaching model one project week semester resulted series discussions three main stakeholders academic institute industry partner students key challenge held interpreting voice really really want past experiences show universities industry come together form partnerships differences language terminology created barriers academic hybrids academic transferred professional practice higher education key allowing move language restrictive language back ensure close frequent interaction students industrial site built semester long projects brings number new challenges particularly identifying live projects suitable level study rules engagement students gain access floor health safety intellectual property rights maintaining general skills company approach resolution dimensions outlined demonstrate work relevant degree programs require unique set competencies develop implement
plant three dimensional computer aided design cad models typically consist logical configuration equipment specifications ports shapes cad models used master information throughout plants entire lifecycle many stakeholders involved lifecycle providing method sharing plant cad models among various stakeholders important standard international organization standardization iso family standards intended support sharing integrating information life process plant therefore important iso support plant cad models order address issue study investigates standardized method exchange plant cad models using iso information requirements regarding plant cad models established iso reference data classes attributes templates extended cover information requirements demonstration proposed method developed prototype platform plant cad models iso loaded retrieved elsevier ltd rights reserved
objective compare cause health care utilization costs patients schizophrenia treated monthly atypical oral antipsychotic therapy methods retrospective claims based analysis among adult california medicaid patients schizophrenia claims july december continuous health plan enrollment year pre post index date initiation date baseline characteristics reported propensity score matching greedy match method used create two matched cohorts treatment patterns cause health care utilization costs month follow period compared two matched cohorts results two matched cohorts patients produced similar baseline characteristics month follow period patients significantly less likely treatment switch new therapy patients fewer inpatient visits lower mean hospitalization days days inpatient costs pharmacy costs significantly higher cohort total costs significantly different matched cohorts conclusions patients schizophrenia treated significantly fewer inpatient hospitalizations associated costs significant difference total costs two cohorts study subject limitations associated claims data inability examine clinical severity etc
protein counteract kinases reversible phosphorylation events numerous signal transduction pathways eukaryotes type represent major group plants recent discovery novel acid aba receptors placed center stage major signaling pathway regulating plant responses stresses plant development several studies provided deep insight vital roles various plant processes global analyses gene family model plants contributed understanding genomic diversity conservation across plant species review discuss genomic structural accounts plants recent advancements interaction paradigm sucrose related kinases aba signaling also highlighted addition expression analyses important roles regulation biotic abiotic stress responses potassium deficiency signaling plant immunity development elaborated knowledge functional roles specific exploited genetic manipulation crop plants genetic engineering using genes provide great agricultural biotechnology sector terms desired traits including higher degree stress tolerance productivity without yield penalty
designing clinical trials focused functional constipation therapies understanding normative values populations selected using rome iii criteria important estimating baseline symptom severity power analysis sample size calculations objective review determine normative ranges stool frequency form adults functional constipation rome iii criteria eligible studies reported stool frequency form random effects meta analysis performed subgroup analyses explore sources heterogeneity total studies groups subjects included pooled estimates weekly stool form scale heterogeneity high outcomes subgroup analysis revealed weekly bowel movement frequency higher larger smaller studies studies conducted europe compared stool form use daily diary versus subject recall sole explanatory variable conclude adults functional constipation significant variation stool frequency form explained part study design
background aims genital rare chronic condition skin causes external reported association crohns disease mechanisms disease optimal methods treatment poorly understood methods retrospective review male patients genital presenting genital performed determine clinical histopathological features condition relationship intestinal crohns disease results combination reported presentation patients patients associated intestinal crohns disease average time symptom onset diagnosis months half cutaneous biopsies contained non contained patients responded oral steroids initially recurrence common complete partial response achieved patients treated three six patients responded anti tumour necrosis factor tnf therapy small proportion patients required surgery debilitating disease conclusions genital rare condition presents genital frequently delay diagnosis strong association intestinal crohns disease genital associated gastrointestinal symptoms prompt careful evaluation exclude genital crohns disease
effect geosynthetic layers moisture distribution plastic deformation road sections studied using numerical simulations geosynthetic layers consisted top bottom transport layer nonwoven geotextile referred capillary barrier drain previous researchers two geotextile types modeled transport layer woven nonwoven polypropylene numerical models verified published results obtained soil geotextile column inclusion geosynthetic layers interface aggregate base course abc increased decreased abc simulated rainfall event woven geotextile led higher abc compared nonwoven polypropylene geotextile geosynthetic layers decreased plastic deformation road sections combined mechanistic hydraulic actions increasing thickness asphalt abc layers decreased reinforcement effect geotextile increasing beneficial hydraulic effect term level sections thinner asphalt layer woven functioning transport layer decreased plastic deformation profile compared profile nonwoven polypropylene geotextile increasing thickness asphalt layer however reduced difference approximately sections inclusion woven layer decreased plastic deformation approximately profile nonwoven polypropylene regardless aggregate base course thickness used analysis american society civil engineers
oil palm important industrial crop usually harvested obtain lipids proteins however biomass source important chemical several industrial applications aim work extract cellulose cellulose oil palm fibers initially fibers resulting two fractions rich black cellulose rich pulp recovered black totally free applied cellulose fibers characterized using several methods including sem sem tem zeta potential tga ftir treatment improved amount crystalline cellulose pulp yielding good thermal stability length diameter aspect ratio presented high purity rich structure good thermal stability characteristics highlight potential use green building block materials renewable biomaterials elsevier rights reserved
user authentication crucial security systems although many complex secure based authentication mechanisms majority users prefer employing simple viable rubber attacks image sequence based introduced overcome issues textual objective work evaluate cognitive memory performance image based user authentication systems via eeg recordings image sequence training task observed increased activity alpha rhythms channel augmented levels beta rhythms channels suggesting users personalized authentication alpha numeric based linking potential roles implicit explicit sequence learning improving human user authentication
various online systems offer lightweight process creating accounts confirming address users easily join minimum effort however attacker process obtain multitude accounts use malicious purposes based solutions proposed limit spread accounts establishing price terms computing resources per identity requested although effective distinguish requests coming presumably legitimate users potential attackers also lead significant waste energy computing power paper build adaptive complement waiting time introduce green design lightweight long term identity management complexity assigned based reputation origin source identity requests reduces energy consumption caused solving also take advantage lessons learned massive distributed computing come design makes processing useful based set experiments show solution provides significant energy savings makes solving useful task compromising effectiveness limiting spread accounts elsevier rights reserved
monolayer two dimensional materials promising optical properties hold potential solar photovoltaic devices efficient solar high absorption especially wavelengths slightly smaller semiconductor wavelength spectrum solar cells higher internal quantum efficiency lower energy loss lattice vibration resultant higher power conversion efficiency materials integrated structures enhance absorption fabrication challenges hindered practical applications structures theoretically experimentally demonstrated simple methodology design efficient material generally sub nanometer planar optical placing sub nanometer film either onto transparent layer metallic film substrate structure transparent layer substrate structure sunlight illumination show always exist pair transparent layer thickness incident angle structures achieve absorption broadband angle robust absorption structure structure absorption times greater prior theoretical achieved monolayer near band edge demonstrate material versatility even materials low losses counter intuitive conventional absorber designs material solar cells designed power conversion efficiency four fold increase compared prior designs proposed methodology applicable numerous materials atomic layer sub nanometer thicknesses way efficient sub nanometer thick energy harvesting devices simple planar structures
mitochondrial dna mtdna variation implicated many common complex diseases inconsistent results common introduce novel mutational load hypothesis also considers collective effect mainly rare variants utilising program apply new methodology investigate possible role mtdna two cardiovascular disease cvd phenotypes hypertension within two population cohort mean age studies looked african mtdna variation context complex disease none using complete sequence data cohort study also extend knowledge african mtdna variation complete sequences southern especially represented cohort showed prevalence rates hypertension identify statistically significant role mtdna variation association hypertension cohort however opinion method described find wide application field especially useful cohorts multiple locations variety mtdna lineages traditional association method particularly likely generate spurious results context association common complex disease copyright institute genetics developmental biology chinese academy sciences genetics society china published elsevier limited science press rights reserved
introduction little reported demographic clinical features major depressive disorder mdd comorbid chinese patients study examined frequency comorbid chinese mdd patients together demographic clinical correlates prescribing patterns psychotropic drugs methods consecutively collected sample patients mdd examined major psychiatric hospitals china patients demographic clinical characteristics psychotropic drugs prescriptions recorded using standardized protocol data collection procedure diagnosis established using mini international neuropsychiatric interview medications ascertained included antidepressants antipsychotics mood results one hundred three patients fulfilled criteria multiple logistic regression analyses compared non counterparts mdd patients depressive episodes atypical features including increased appetite sleep weight gain frequent lifetime depressive episodes less likelihood family history psychiatric disorders significant difference pattern psychotropic prescription groups conclusions important differences demographic clinical features comorbid chinese mdd patients compared previous reports clinical profile found study implications treatment decisions
introduction fifth edition diagnostic statistical manual mental disorders dsm includes significant revision eating disorders objective study compare distribution diagnosis adolescents according dsm dsm criteria second objective study psychopathological differences patients based dsm whose diagnosis changed applying dsm criteria methodology one hundred one adolescents diagnosed mean years evaluated clinical interviews scales eating psychopathology anxiety depression results applying dsm criteria led significant decrease diagnosed cases eating disorders otherwise specified significant increase anorexia nervosa bulimia nervosa significant psychopathological differences found patients diagnosed based dsm criteria newly diagnosed based dsm criteria discussion using dsm criteria adolescents leads significant decrease frequency diagnosis similar psychopathological characteristics observed patients diagnosed based dsm switched based dsm conclude new criteria dsm valid adolescent population
algorithms shape practice security proliferation point shift political security nature extent shift article argues efforts strengthen global health security major drivers development proliferation new algorithmic security technologies response epidemic potentially lethal infectious disease outbreaks including hiv aids severe acute respiratory syndrome middle east respiratory syndrome governments international organizations now using several next generation surveillance systems rapidly detect new outbreaks globally article analyses origins design function three internet based surveillance systems program monitoring emerging diseases global public health intelligence network article shows newly introduced system became progressively upon algorithms mine ever growing volume indirect data sources earliest signs possible new outbreak gradually algorithms heart global outbreak detection turn algorithm marks significant shift underlying problem nature role knowledge contemporary security policy
catalyze condensation reaction living organisms among widely distributed classically divided two classes recently investigation represent primitive form life growing utilizing pathway revealed successively new types especially discovery novel functioning micro conformational change made break one enzyme one reaction review summarizes briefly enzymology classical view latest
senescence marker protein decreases androgen independently aging enzyme involved vitamin biosynthesis present study bone properties knockout mice deficiency vitamin synthesis investigated reveal effects exogenous vitamin supplementation bone formation mineral content mineral density bmd mandible femur wild type mice months age without vitamin supplementation measured dual energy ray absorptiometry body bone weight age groups decreased became significantly lower wild type mice bones mice rough porous bmd significantly wild type oral supplementation vitamin eliminated differences body weight bone weight bmd wild type mice age results indicate bone degeneration mice caused lack vitamin mouse strain appropriate model bone metabolism humans ability synthesize vitamin
background linking injury reporting general motion patterns provide insight potential injury mechanisms development prevention strategies objective characterize injuries sustained members large canadian metropolitan fire department year span methods data taken injury reports career injuries described job duty type body part affected general motion pattern employed time injury lifting results injuries reported categorized sprains strains musculoskeletal disorders frequent affected back categorized job duty sustained working fire station physical training related activities attributed operations furthermore associated job duty differentiate types injuries sustained back injuries occurred primarily lifting knee injuries stepping shoulder injuries related activities conclusions injuries just problem injury better understood linking injury location type motion patterns rather job information assist developing general prevention strategies fire service
measure switching probability distributions first second switches delta intrinsic junctions measure switching probability distributions design current source introduced microcontroller resolution accuracy sufficient measuring switching probability distributions intrinsic junctions first switch crossover temperatures thermally activated escape macroscopic quantum tunneling range crossover temperatures second switch approximately samples critical densities respectively analyze critical current density dependence crossover temperature second switch crossover temperature decreases increasing critical current density explained neither single junction model heating effect peculiar phenomenon observed second switch consider attributed capacitive coupling strength capacitive coupling weaker higher critical current density charge screening length shorter due increase carrier density
plays critical role several processes involved skeletal cardiac muscle contraction one key step cardiac excitation contraction coupling activation cardiac receptor cytosolic elevations although process critical skeletal coupling activation inhibition skeletal receptor seem important overall muscle function channels fall within large category binding proteins highly selective binding sites receive translate various signals specific functional responses however little known precise localization sites within cytosolic assembly isoforms although several experimental lines evidence highlighted hand nature hand proteins share common helix loop helix structural motif highly conserved residues involved coordination first step predicting hand positive regions compare primary protein structure hand motif employing available bioinformatics tools although simple method search regions provide solid evidence regarding regions bind isoforms review seek highlight key findings experimental approaches strengthen future efforts identify cytosolic binding sites responsible activation inhibition channel much less work conducted channel
background proven effective treating opioid use disorder however high cost limited prescribing capacity restrict access effective medication assisted treatment opioid use disorder objective examine whether medicaid expansion physician prescribing capacity impacted utilization covered medicaid research design used quasi experimental difference design compare pre post changes medicaid covered prescriptions spending states implemented medicaid expansions affordable care act subjects medicaid expansion states late expansion states measures medicaid prescriptions spending centers medicare medicaid services medicaid drug utilization files results state implementation medicaid expansions associated increase medicaid covered prescriptions increase spending physician prescribing capacity also associated increased utilization conclusions medicaid expansion potential reduce financial barriers utilization improve access medication assisted treatment opioid use disorder active physician participation provision needed ensuring medicaid expansion achieves full potential improving treatment access
reported many people dementia require hospitalizations objective present study determine predictive factors hospitalizations people dementia methodsa total individuals dementia living veterans home southern taiwan consecutively enrolled prospective follow hospitalization events recorded resultsthe mean age residents dementia mean follow time population among individuals suffered malnutrition risk malnutrition minimal nutritional assessment short form score individuals body mass index individuals previously overall residents hospitalized follow period individuals previous falls significantly increased risk hospitalization odds ratio furthermore three factors significantly associated risk fall including strength malnutrition mini mental state examination score conclusionsthe results present study showed hospitalization frequent event residents dementia living long term care facility major predictor hospital admission history previous fall screening dementia history falls associated risk factors falling help identify risk hospitalization thus comprehensive intervention reduce hospitalization int
background october pharmacist driven program implemented womens hospital ensure continued adherence prescribing guideline focusing indications intravenous immune globulin use dosing per ideal body weight objective primary objective describe program tertiary academic medical center methods prospective observational study january december patients ordered receive defined study period included intervention assessed describes pharmacist driven program medication approval primary end point guideline compliance based indication dose dosing weight frequency secondary end points included number patients receiving indications orders discontinued result guideline total amount results total patients identified study time frame top indications bone marrow transplantation hematological malignancy acute solid organ rejection immune thrombocytopenia bleeding patients received indication prescribing guideline patients patients respectively received different dose frequency per prescribed indication orders indications guideline discontinued total study period conclusions program including institution specific prescribing guideline pharmacist driven program ensure guideline compliance appropriateness indication dose academic medical center
objective arterial concentration subjects inflammatory pulmonary disease higher healthy individuals retrospectively analyzed relationship concentration established markers disease severity subjects interstitial lung disease ild methods concentration measured subjects newly diagnosed untreated ild relationships concentration serum biomarker levels lung function findings uptake evaluated results eighty one non smoking subjects studied mean age years among subjects stable idiopathic pulmonary fibrosis ipf acute exacerbation ipf stable non ipf exacerbation non ipf concentrations subjects concentration positively correlated serum levels surfactant protein inflammation index calculated negatively correlated partial pressure oxygen arterial blood predicted diffusion capacity carbon monoxide concentrations subjects negative heart sign higher subjects without negative heart sign conclusion levels subjects ild increased particularly exacerbation correlated parameters reflect pulmonary inflammation
use unmanned aerial vehicles growing significantly many varied purposes mission outdoor uav guided following planned path using gps signals however gps capability become defective environment gps additional safety aid therefore required automatic landing phase independent gps data equipped machine vision systems together analysis used safe automatic landing contributes greatly overall success autonomous flight paper proposes automatic expert system based image segmentation procedures safe landing recognition relative orientation uav platform proposed expert system exploits human experience incorporated machine vision system mapped proposed image processing modules result improved reliability capability incorporated uav especially robust rotary wing clearly desirable fail safe capability elsevier ltd rights reserved
surface meshes recently attracted great interest since frequently used many computer graphics applications meshes often generated representations also scanning devices unfortunately meshes dense contain many redundant vertices irregular sampling make meshes unable support multiple applications storage display compression transmission solve problems reduce complexity mesh quality connectivity regularity improved improvement called hand many researches techniques done exploit mesh local optimize geometric representation paper presents novel approach based planar
objective arginine specific cysteine proteases important virulent factors periodontal diseases however therapeutic drug inhibits proinflammatory events induced enzymes study investigated proinflammatory activities activated coagulation factor examined effect new selective inhibitor proinflammatory events induced methods human fibroblasts stimulated presence absence interleukin matrix metalloproteinase mmp release mrna expression nuclear factor kappa kappa activation assessed using enzyme linked immunosorbent assay elisa northern blotting gel mobility shift method respectively results activated mmp release human fibroblasts activities mitogen activated protein kinase mapk kappa dependent inhibited mrna expression kappa activation inhibited activities vitro vivo conclusion potent inflammatory mediators useful therapeutic drug periodontal disease
construction management processes focused technical aspects minimal consideration social factors among trust prominent impact project efficiency success according construction industry institute study among factors impacted low trust efficiency administrative costs trust defined hard economic driver affects speed cost two three project management preliminary data literature provides evidence trust ignored construction management address gap paper identifies impact construction processes perceived professionals adopted research methodology utilizes survey instrument identify important parameters upon selection processes depend characterize industry professionals view effects process results indicate trust even explicitly stated plays major role processes furthermore direct correlation trust level contractor selection among project delivery methods results emphasize impact trust strategies provide decision makers better understanding actions
transformation research biological fields necessitates design analysis interpretation large data sets preparing students skills experimental design statistical analysis interpretation mathematical reasoning require reform faculty willing able integrate mathematical statistical concepts life science courses new faculty learning community constituted year four years assist transformation life sciences curriculum faculty large research university participants interviewed participation surveyed participation assess impact attitudes toward teaching perceived pedagogical skills planned teaching practice overall meaningful positive impact participants attitudes toward teaching knowledge teaching perceived pedagogical skills interestingly confidence viewing classroom site research teaching declined implications creation development science faculty discussed international union biochemistry molecular biology
background chronic constipation common severe gastrointestinal complaint parkinsons disease pathogenesis remains poorly understood study evaluated functionally distinct neurons relation colonic motility function patients constipation controls methods twenty nine rome iii defined patients enrolled twenty asymptomatic age sex matched subjects served controls colonic transit time measurement conventional evaluated patients performed three groups colonic whole controls processed immunohistochemistry antibodies intestinal polypeptide peripheral markers functionally distinct neurons mrna expression receptors also assessed key results four subgroups patients identified delayed colonic transit plus altered delayed colonic transit altered pattern transit impairment differences number neurons ganglion controls reduced number neurons containing immunoreactivity found controls mrna expression significantly reduced controls conclusions inferences colonic motor rectal sensory functions impaired patients abnormalities associated decreased expression neurons sensory motor abnormalities mediated motor secretory mechanisms likely contribute pathophysiology
aim present study provide descriptive dietary patterns home living older adults examine association sociodemographic diet related variables health psychological factors dietary patterns analyzed using separately cluster analysis men age range women age range older adults aged years cluster analyses showed four distinct dietary profiles gender older men four distinct dietary clusters associated differences sociodemographic diet related variables cognitive function health psychological factors likewise older women four distinct dietary clusters associated differences sociodemographic diet related variables however older women results showed cluster high fish fruit vegetable associated better cognitive function better self rated health depressive symptoms whereas cluster moderate ready meals associated cognitive decline slight depression poor perceived health results emphasize interest take consideration health psychological factors associated dietary patterns better target vulnerability individuals enable effective prevention elsevier rights reserved
objectives determine enhance integration minority students health education thereby improve communication skills cultural sensitivity sample health teacher students norway methods group work intervention period six months afterwards followed action research approach observed health teachers training first year university college classroom interactions data qualitative comprised student self reports survey results along observations three teachers authors study data analyzed using constant comparative approach opinion categorization open coding procedure separate analyses performed observations minority students majority students teachers results ethnic majority minority students experienced increase knowledge problem solving ability experience early intervention first academic year tertiary education students reacted favorably intervention noted class assessments challenges rewards overcoming cultural barriers teacher observation notes confirmed early intervention led increase interaction cross cultural engagement minority majority students compared previous years classes without intervention conclusions early classroom intervention promote engagement prevent formation along majority minority lines method used tailored group assignments diverse working groups beginning students tertiary academic career effective approach attitudes skills fostering awareness sensitivity
cotton fiber unique experimental system studying plant cell elongation cell wall biogenesis proteins extracellular play important roles various aspects plant growth development present work four genes cloned cotton fiber rapid amplification cdna ends race genes code classical containing terminal signal sequence central domain rich pro terminal hydrophobic transmembrane domain additionally four putative proteins contain two like domains one like domain putative terminal lipid signal sequence northern blotting analysis gene specific probes indicates transcripts accumulate fiber days post whereas abundantly expressed developmental stage switching elongation secondary cell wall synthesis furthermore quantitative reverse transcription polymerase chain reaction analysis demonstrates like genes specifically expressed fibers also fibers like domains typically found adhesion proteins animal cell specific expression patterns together presence like domains suggest roles like cell cell communication cotton fiber elongation secondary cell wall development
testing breast cancer recurrence risk became available yet many eligible patients remain study evaluated variation testing rates organizational factors associated variation setting without financial influences testing conducted retrospective cohort study using electronic data surveys within northern california large integrated health care system analyses included test eligible patients practice groups receipt testing evaluated generalized linear mixed models overall eligible patients testing rates varied widely among practice groups ranging case mix adjustment difference among practices greater variation associated patient characteristics including comorbidities race ethnicity similar associated tumor size practice group factors statistically significant contributors variation testing adjusting patient factors patients likely tested female aor practice whose chief high testing rate aor per increase percent tested leadership practices play key role variation genomic test use cancer recurrence risk even healthcare system without financial barriers testing leverage point implementing desired practice changes new genomic advances
vitamin binding protein gene encodes alpha globulin vitamin metabolites serum given role vitamin onset disease progression analyzed frequencies three polymorphisms within gene italian multiple sclerosis patients healthy controls none polymorphisms showed association onset progression results suggest involved pathogenesis elsevier rights reserved
work citrate acetate investigated chitosan order provide stable films choose appropriate film composition study chitosan citrate acetate films without glycerol prepared characterized thickness moisture content degree swelling total soluble matter acid medium simultaneous thermal analysis differential scanning calorimetry chitosan films citrate buffer showed greater physical integrity resulted greater thicknesses lower moisture absorbance lower tendency solubility acid medium better swelling capacities according thermal analyses films higher interaction water considered important feature cosmetic application since composition prepared citrate buffer without glycerol considered present better physical integrity applied investigate acid release skin model treated films without acid show stratum hydration within min results suggest chitosan citrate film prepared without glycerol promotes cosmetic effect skin presence absence acid elsevier rights reserved
present parallel interacting stochastic approximation annealing algorithm stochastic simulation procedure global optimisation extends improves stochastic approximation annealing using population monte carlo ideas efficiency standard algorithm depends self adjusting mechanism presents stability issues high dimensional optimisation problems proposed algorithm involves simulating population chains interact manner significantly improves stability self adjusting mechanism search global optimum sampling space desired convergence properties square root cooling schedule used implemented parallel computing environments order mitigate computational overhead result address complex optimisation problems difficult satisfactory address demonstrate good performance proposed algorithm challenging applications including bayesian network learning protein folding numerical comparisons suggest outperforms simulated annealing stochastic approximation annealing annealing evolutionary stochastic approximation monte carlo
objective warfarin widely used stroke prevention patients atrial fibrillation compared rates stroke major bleeding patients high stroke risk low bleeding risk profile warfarin treated warfarin untreated periods method insurance claims six commercial medicaid medicare databases analyzed patients treated warfarin score score baseline identified incidence rate ratios stroke major bleeding calculated versus episodes person time first days versus beyond days episodes results among patients anticoagulant prophylaxis warfarin significantly reduced stroke risk ranging increased major bleeding risk ranging stroke major bleeding rates higher first days beyond conclusion patients high risk stroke low risk bleeding data confirm effectiveness anticoagulation stroke prevention decrease stroke risk anticoagulation risk major bleeding events particularly among elderly patients potential risks warfarin initiation warrant attention especially among patients stop start therapy repeatedly
conditioning highly effective reducing incidence acute chronic graft versus host disease reduced intensity transplantation monotherapy less frequent lower dose scheduling used donors optimal regimen matched unrelated donors defined retrospective observational study patients incidence severity compared patients receiving different dose schedules standard regimen days days days patients treated developed acute grades incidence respectively whereas developed chronic excess severe acute grades iii observed cohort versus relative risk severe acute grade remained fold higher cohort compared cohort adjustment differences hla match age gender mismatch cytomegalovirus risk diagnosis findings indicate schedule comparable schedule attenuated schedules increase risk severe grade american society blood marrow transplantation published elsevier inc rights reserved
context previous research found exposure violence home community electronic media associated childrens adolescents normative expectations concerning use violence indicators violent behaviors youth objective purpose study examine relationships frequency high school students reported watching television engaging date carrying behaviors design initial analysis consisted cross sectional study simple random sample high school students followed longitudinal analysis students month period setting setting public high schools city county system participants used simple random sample students main outcome measures primary outcome variables included frequency date previous months alcohol drug involvement associated last date fight results significant correlations frequency watching television previous weeks engaging date general carrying males females although relationships stronger among females among males frequency watching highest among students reporting date either victim drinking alcohol using illegal drugs analyzed using logistic regression strongest relationships observed frequency watching date fight among females cross sectional longitudinal analyses findings persisted adjusting multiple factors conclusions males females frequency watching highest among students dates alcohol drugs involved association watching date stronger among females males relationship watching television dating violence also stronger among females remained consistent month time period
pediatric lymphoma common sub saharan africa survival estimates often based limited follow incomplete retention introducing potential bias compared follow overall survival passive active tracing within prospective cohort children lymphoma median follow times months interquartile range iqr months iqr passive active follow respectively twelve month overall survival confidence interval passive active follow passive follow significantly overestimated underestimated mortality efforts improve retention regional studies needed
computer aided design cad model shared cloud collaboration challenge design features model effective knowledge protection paper presents novel encryption approach based geometric transformation encryption mechanisms feature based cad models supporting cloud enabled collaboration innovation approach centered enhanced encryption transformation matrix characterized parametric randomized self adaptive feature encryption controllable parameters transforming features terms deformation defined facilitate users conduct encryption transformation flexibly random probability mechanism embedded parameters order guarantee security encrypted model furthermore parameters enhanced self adaptive ensure geometric validity encrypted model approach validated via number complex models demonstrate applicability effectiveness industrial applications
core detector response calculation important part reactor design however response function measured experiments quantitatively core detector response simulation therefore required decades code used dedicated tool nowadays engineers expressing interest using monte carlo method instead method simulations expected monte carlo method give higher accuracy paper modeling simulation core detector responses briefly reviewed based korean unit reactor differences simulation monte carlo simulation compared sensitivity computational conditions also discussed shown problem dependence cross sections dependence spatial discretization core detector response calculations strong expected however ray effect main calculation based analysis two benefits shown using direct calculation firstly impact ray effect eliminated without using angular discretization secondly direct calculation easier perform based powerful ability modeling parallel computing monte carlo code new values adopted dynamic control rod reactivity measurement unit reactor results show new values improve error measured control rod worth percentage elsevier ltd rights reserved
tissue important function total energy homeostasis dysregulation contribute lifestyle related diseases type diabetes cancer cardiovascular diseases aim study investigate genome wide mrna expression adipose tissue healthy men exercise intervention identify genes pathways mediate beneficial effect regular exercise also investigated difference adipose tissue mrna expression individuals without family history type diabetes methodsthe month supervised exercise intervention conducted healthy men age bmi previous low level physical activity rna analysed using human gene arrays exercise identified significant transcripts differentially expressed exercise false discovery rate including genes encoding respiratory chain histone subunits small rnas ribosomal proteins additionally pathways enriched response exercise include oxidative phosphorylation proteasome many metabolic pathways whereas wnt mapk signalling pathways regulated exercise significant differences mrna expression individuals without family history type diabetes increased expression genes involved oxidative phosphorylation opposite seen adipose tissue elderly obese individuals low physical fitness study thereby demonstrates mechanism beneficial effect exercise
paper mainly introduces novel deep learning mapping framework oriented ternary change detection task information unbalanced images different traditional intensity based methods available framework based operation features extracted two images due excellent performance deep learning information representation feature learning two networks used first stacked used two images serving feature sample selection process stacked mapping network employed obtain mapping functions establishing relationship features class finally comparison features made final ternary map generated clustering comparison result work highlighted two aspects firstly previous works focus two images similar properties whereas framework based two images quite different properties usually encountered case secondly framework based analysis feature instead superficial intensity avoids unbalanced information large extent parameter tests three datasets provide appropriate parameter settings corresponding experimental results demonstrate robustness effectiveness terms accuracy time complexity
introduction case control study compares patients healthy group symptomatic patients cartilage damage osteoarthritis materials methods control group recruited routine medical examinations patients general medical offices included case group total patients undergoing result chronic discomfort patients questioned regard occupational stress athletic stress results significantly increased risk cartilage damage osteoarthritis found perceived increased stress occupational settings individual stresses joint occupational settings following effects found exposure heavy work force vibration repetition sport types represent potential risk factor development cartilage damage osteoarthritis joint conclusions cartilage damage radiographic osteoarthritis joint rare respect overall prevalence osteoarthritis large number patients cartilage damage radiographic osteoarthritis joint occupational athletic stress factors injuries sustained addition causes prove possible causes secondary symptomatic forms osteoarthritis
microrna signatures cells alveolar macrophages currently lacking ipf sought investigate expression fibrosis related micrornas cellular component ipf thus focused micrornas previously associated fibrosis mir mir mir let mir rapid ipf progression mir mir mir mir mir among tested micrornas mir mir found significantly downregulated ipf mir mir expressed cells importantly downregulation mir inversely correlated significantly increased levels mrna ipf cells collagen found mainly overexpressed alveolar macrophages cell types immunofluorescence view downregulation mir tested response macrophages cytokine observed downregulation mir conversely proinflammatory stimulation lead mir upregulation upon examination mrna levels known mir targets significant correlations observed cells however increased levels total akt akt phosphorylation observed ipf cells furthermore mir inhibition macrophages resulted significant increase phosphorylation study highlights importance microrna signatures ipf identifies significant differences mir akt mir collagen axes cells ipf patients
evaluated model automatically reinforced self behavior based sensitivity changes functional analysis conditions presence self restraint current study tested model applying datasets automatically reinforced published identified datasets included sufficient data permit similar original study subtype generally amenable treatment using reinforcement alone whereas subtype conclusions drawn subtype due small number datasets nevertheless findings support model suggest sensitivity disruption alternative reinforcement important dimension automatically reinforced findings also suggest automatically reinforced longer considered single category additional research needed better understand treat subtype
background developmental dysplasia hip common pathological condition musculoskeletal system infants results congenital developmental hip joint spectrum pathologies affecting infant hip ranging asymptomatic subtle radiographic signs mild instability dislocations dysplasia saudi family three affected individuals identified genetic analysis performed detect possible genetic defect underlying affected members family methods performed whole genome genotyping using illumina array whole exome sequencing using rapid capture kit illumina instrument four individuals family results snp data analysis identify runs copy number variations identity descent ibd analysis whole genome genotyping data identified shared haplotypes chromosome affected individuals analysis data identified rare heterozygous variants genes affected individuals multiple prediction software predicted variants identified damaging moreover silico analysis showed regulates expression using variety transcription factors conclusion results indicate functional interaction family studied due combined effect variants variants also present asymptomatic mother suggesting variants incompletely study provides first evidence inheritance family extends spectrum genetic heterogeneity human disorder
arabidopsis gene introduced soybean agrobacterium mediated transformation four independent resistant lines obtained result pcr southern blotting northern blotting analyses demonstrated gene successfully inserted soybean genome stably expressed resistant lines stability expression salt resistance evaluated soybean transformants generations two independently derived transgenic lines high expression level selected generation absence selection pressure pcr pcr examinations revealed highly expressed investigated transgenic furthermore transgenic plants showed resistant salt stress homozygous plants taken together results indicated constitutive expression enhanced salt tolerance soybean generations suggesting great potential use improving salt tolerance plants genetic engineering
traditional cognitive assessment neurological conditions involving physical disability often prevented presence verbal motor impairment date extensive motor verbal free neuropsychological battery available purposes adapted set neuropsychological tests assessing language attentional abilities executive functions social cognition eye tracking control explored feasibility sample healthy participants thirty healthy subjects performed neuropsychological assessment using based neuropsychological battery together standard paper pencil cognitive measures frontal frontal assessment battery working memory abilities digit sequencing task global cognitive efficiency cognitive assessment psychological measures anxiety state trait anxiety inventory depression beck depression inventory bdi also collected usability questionnaire administered significant correlations observed paper pencil screening working memory abilities based neuropsychological measures based battery also correlated poor correlations observed usability aspects found influenced working memory abilities psychological components based neuropsychological battery developed provide extensive assessment cognitive functions allowing participants perform tasks independently integrity motor verbal channels studies aimed investigating validity usability components neurological populations motor verbal impairments
gastroesophageal reflux disease common condition substantial impact quality life patients leading risk factor esophageal adenocarcinoma now therapy proton pump inhibitors basic method treatment patients however one third patients respond therapy used causes refractory fairly large group heterogeneous factors contributing adequate dosage among factors low compliance patients prescribed treatment regimen nocturnal acid breakthrough gene polymorphism syndrome functional diseases gastrointestinal tract non acidic patient thoracic esophageal motility disorders increased number duration transient lower esophageal relaxation periods hour impedance high resolution esophageal now informative diagnostic techniques patients fail respond ppi therapy techniques allow one timely recognize causes refractory make differential diagnosis entities timely correct therapy individual patient
determine mindfulness older adults improves cognition improves mental health physiology least stressed year olds randomized week intervention control outcome measures assessed baseline months later visit primary outcome measure executive function attentional measure task outcome measures included additional cognitive assessments salivary cortisol respiratory rate heart rate variability positive negative affect schedule center epidemiologic studies depression perceived stress scale pss neuroticism extraversion openness neo personality traits health related quality life one hundred twenty eight participants completed study though visit assessments significant change primary cognitive outcome measures even statistical adjustment multiple outcomes self rated measures related negative affect stress significantly improved intervention compared group negative pss health related quality life vitality mental health component mental health component score improved minimum clinically important difference also significant changes personality traits neuroticism changes positive affect observed group differences salivary cortisol heart rate variability moderate sized improvements self rated measures improvements cognitive function physiological measures potential explanations discrepancy stress related outcomes discussed help improve future studies
purpose purpose article review discuss varied ways computer programming introduced schools families new form learning paper examines around coding within academic journals popular media articles past three decades article argues despite best intentions media researchers around computer science schools become reality first needs greater focus monitoring better understanding exactly programming presented wider public design methodology approach paper represents analysis peer reviewed books journal articles news articles related students learning needing learn computer programming level terms criteria inclusion addition publication date article three considerations article needed focus grade levels article needed focus introductory computer programming initiatives rather advanced courses topics article needed specifically focus school based learning environments findings findings point three distinct ways introductory coding initiatives perceived new literacy grounded math technical skill ultimately paper propose single defining rather argues one matter considerably determining future entering entering schools educators need make effort consider multiple without choosing just one research limitations implications terms research limitations article exhaustive analysis used introduce schools past years rather identifies leading literature makes important first step examining role presentation new course study practical implications article intended educators researchers administrators gain better understanding social implications article intended educators researchers administrators likewise understand present students families potential course study originality value currently considerable discussion teaching high schools middle schools even elementary schools however little examination past attempts bring schools attempts inform current advocacy
help specialist clinicians often sought staff residential nursing care homes work people dementia whose behaviour challenging model framework process developed help care staff understand improve care group model use sharing information staff develop effective care plans shared formulation sessions characteristic model clinicians take role group helping staff reach consensus needs change sessions difficult manage intra inter group processes emerge group express paper aims explore processes play shared formulation sessions suggest ways approach manage effective collaborative working
propulsion systems gained significant interest transport industry develop energy efficient systems energy storage systems high energy batteries electrochemical double layer capacitors high power batteries electric motors energy management strategies advanced power electronics converters play important role development new generations clean vehicles therefore paper proposes new architectures carriers one highway vehicles used move containers order improve carriers efficiency reduce greenhouse emissions energy proposed series hybrid carrier based small energy storage system option series hybrid based reduced internal combustion engine option full electric new full electric based dynamic wireless power transfer system paper accurate quasi static model conventional carrier developed described detail proposed architectures designed modeled using matlab simulink article also presents optimal design energy storage systems utilized based energy storage system type thorough comparative study new carrier described detail finally developed model simulation results validated real measurements elsevier ltd rights reserved
study sought describe morphological changes taking place reticulum prenatal development using immunohistochemical techniques total embryos used first stages prenatal life birth differentiation reticulum separate compartment primitive gastric tube observed days prenatal life gestation days gestation wall comprised three layers internal epithelial layer middle layer tissue external layer primary visible days gestation epithelial stratum earliest histological differentiation future cells secondary observed days gestation first became apparent lateral surface primary days gestation visible days gestation primary neuroendocrine cells detected days gestation glial cell markers glial acidic protein vimentin observed days gestation days gestation respectively markers neuropeptide intestinal polypeptide detected days gestation conclusion prenatal development reticulum like appears take place somewhat earlier sheep cattle similar rate reported
performed systematic review designed characterize clinical phenotypes outcomes indigenous populations rheumatic disease enhance understanding rheumatic disease presents indigenous populations allow better projection healthcare needs communities affected systematic search performed medical medline embase cinahl indigenous conference abstract databases june search terms indigenous populations combined terms inflammatory arthritis conditions connective tissue disorders crystal arthritis osteoarthritis studies included reported disease features disease activity measures patient reported outcomes canadian american australian new zealand indigenous populations data extracted duplicate narrative summary prepared total abstracts reviewed underwent full text review met inclusion criteria nearly studies described outcomes north american populations four studies australia four studies new zealand majority studies rheumatoid arthritis systemic lupus erythematosus indigenous patients rheumatoid arthritis higher disease activity reported significant impact patient reported outcomes quality life non indigenous patients features described north american populations patients advanced manifestations systemic lupus erythematosus frequent indigenous populations osteoarthritis severe new zealand populations existing literature supports differences disease phenotype severity indigenous populations canada america australia new zealand encourage investigators area research undertake contemporary studies differences phenotype severity biologic etiology merely reflecting differences access care provide longitudinal assessment outcomes diverse populations
work addresses influence soil confinement creep behavior geotextiles presenting results full scale field test two samples nonwoven polypropylene geotextile inserted different depths high sand fill samples loaded constant tensile load period maintain constant load test system weights load cells used sand fill samples instrumented several types transducers order measure strains displacements applied forces soil stresses temperature direct shear inclined plane tests conducted measure mechanical properties interfaces model proposed analyze field results confined creep behavior field compared results obtained authors isolation creep results obtained laboratory tests elsevier ltd rights reserved
paper presents general agent based system identification framework potential solution data driven models building systems developed integrated improved efficiency flexibility scalability compared centralized approaches proposed method introduces building sub system agents optimized independently solving locally maximum likelihood estimation problem several models considered sub system agents systematic selection approach established considering root mean square error parameter sensitivity output trajectory parameter correlation final model integrated selected models agent two different approaches developed integration shared parameter model distributed method free shared parameter model based decentralized method results case study high performance building indicate model prediction accuracy new approach fairly good implementation predictive control
purpose review like factors family transcription factors regulate integral functions endothelial cells including inflammation proliferation growth apoptosis cell differentiation plasticity migration review focus role physiological activity loss vascular pathology recent findings new studies pointed role micrornas atherosclerotic areas providing another level signaling regulation summary important regulators almost facets endothelial biology making promising therapeutic target treatment endothelial dysfunction cardiovascular disease research needed fully characterize functions
adolescent sexual development across board seen normative risky behavior depending factors age onset number partners longitudinal study identified developmental trajectories annual number sexual partners adolescence emerging adulthood antecedents ages participants females annually reported number sexual partners measures adolescent family characteristics taken ages used predictors group based modeling identified four trajectory groups group low increasing group medium increasing group multiple partners group multinomial regressions indicated better social competence increased chances belonging multiple partners group compared low increasing groups substance use predicted membership multiple partners group compared group moreover females low increasing medium increasing groups results imply greater diversity sexual development proposed literature highlight importance identifying strengths competencies associated healthy sexual development along early risk factors
graphs powerful versatile data structures used represent wide range different types information article introduce method analyze visualize important class data described paths analysis path useful variety applications diverse fields transportation computer networks molecular dynamics proposed method concept band depth ensemble paths graph provides center ordering paths ordering turn used construct generalization conventional plot called path applies paths graph utility path demonstrated several examples path including paths defined computer networks roads supplementary materials article available online
unclear whether observed memory impairment anorexia nervosa depends semantic structure categorized words material encoded aimed investigate processing semantically related information performance assessed recall learning recognition test adult women restricting binge eating subtype average disease duration healthy controls using extended version auditory verbal learning test applying semantically related unrelated word stimuli term memory immediate recall learning regardless semantics words significantly worse patients whereas long term memory delayed recall recognition differ patients controls stimuli better effect memory recall compared impaired short term versus long term memory discussed relation dysfunctional working memory copyright john wiley sons ltd eating disorders association
cardiac useful imaging technique diagnosis dementia lewy bodies however serious disadvantage demands long examination time objective study evaluate statistically usefulness heart ratio early phase differential diagnosis total patients examined including non alzheimers dementia patients mean early ratio non group group mean delayed ratio non group group cutoff point early images sensitivity specificity diagnostic accuracy respectively area curve indicating moderate accuracy analysis indicates images early phase alone sufficient differential diagnosis alzheimers disease
recently completed bridge west province china long span suspension bridge across deep view particular problems posed surrounding landscape conditions minimize impact bridge natural environment novel girder suspension structure adopted large difference span main cable girder part design process method stability analysis combined system tunnel rock developed addition solve problems involved transportation girder long span suspension bridge area novel girder track cable method developed american society civil engineers
background tens millions risk complications live attenuated vaccine reduces risk although questions regarding effectiveness durability protection routine clinical practice remain used medicare data investigate effectiveness durability methods retrospective cohort study included beneficiaries ages years january july multiple adjustments account potential bias made beneficiaries matched beneficiaries primary analysis beneficiaries received vaccination secondary analysis outcomes community hospital settings analyzed including results among eligible beneficiaries average age years primary analysis found community first subsequent years respectively secondary analysis respectively primary analysis first subsequent years respectively hospitalized respectively differences age group significant conclusions primary secondary analyses provided protection across ages effectiveness declined time higher better preserved time associated hospitalizations community
background ankle sprains common injury sports studies examined epidemiology individual ligament injuries specifically lateral ligament complex llc ankle purpose describe epidemiology including estimated yearly national incidence llc sprains among national athletic association athletes study design descriptive epidemiology study methods injury surveillance data sports injury surveillance program academic years used analysis injuries included analysis diagnosis llc llc rates rate ratios cis calculated sample national estimates annual incidence llc sprains across entire student athlete body sports also calculated results academic years llc sprains reported rate per athlete exposures aes llc sprains comprised reported sports injuries also estimated llc sprains occurred annually among sports sports highest llc rates mens aes womens aes llc sprains occurred practices however llc rate higher practices also llc sprains identified recurrent injuries largest proportions recurrent llc sprains found within womens womens outdoor track womens field mens llc sprains athlete returned play less hours athlete required days returning play including return play conclusion llc sprains commonly reported injury diagnosis among united states student athletes continued examination interventions aim reduce incidence severity recurrence llc sprains specifically women warranted
work aims characterize personal exposure aromatic hydrocarbons non fire work environments fire stations assesses respective risks eighteen considered priority pollutants monitored breathing zones workers five portuguese fire stations normal shift obtained levels fulfilled existent occupational exposure limits air quality guidelines total concentrations sigma range light compounds rings predominant sigma whereas rings accounted sigma fuel biomass traffic emissions use oils identified main sources exposure studied fire incremental lifetime cancer risks recommend guideline thus negligible studied subjects health based guideline level exceeded times fire results thus show even non fire situations exposed levels promote adverse health outcomes therefore respective occupational exposures compounds carefully controlled elsevier rights reserved
aim study develop novel multifunctional nanoparticle peg form multifunctional drug delivery system aim super iron oxide nanoparticles simultaneously synthesized encapsulated peg via double method optimum size encapsulation efficiency diagnostic applications considered preparation parameters systematically investigated physicochemical characteristics optimized nanoparticle studied nanoparticles prepared optimized parameters toxicity nanoparticles compared human breast cancer cell line mcf optimum preparation parameters obtained polymer equal polymer equal sucrose per polymer hydrodynamic diameters nanoparticles encapsulation efficiency adjusted vitro release kinetics controlled behavior enhancement ratios concentration nanoparticles equal respectively statistical difference significant value value compared conclusion successfully developed loaded super iron oxide multifunctional drag delivery system future work includes vitro vivo investigation application nanoparticles
assess risk edema following surgery patients allergies atopic disorders medical records consecutive eyes underwent surgery retrospectively reviewed prevalence allergies atopic status development patients known risk factors excluded examination performed using spectral domain optical coherence tomography oct weeks surgery eyes one patient underwent surgery one eye randomly selected odds ratios confidence intervals estimated patients enrolled series patients showed positive allergic status patients suffered atopic syndromes showed allergies atopic diseases occurred eight patients allergy cohort whereas patient atopy cohort developed risk comparable patients allergies atopic diseases patients without allergies atopy allergy odds ratio confidence interval atopy positive status allergy atopy seem increase risk therefore postoperative treatment surgery modified allergic atopic patients
computer laboratories limited resources south african universities improve students access many universities use hands approach computer laboratory access number research studies past two decades written problems presented hands approach turn two alternative approaches suggested address problems problems presented hands approach caused negative impact students performance computer programming subjects students throughput rate two alternative solutions proposed many researchers field virtual laboratories remote laboratories due many challenges students access computer laboratories various problems presented current hands approach south african universities paper investigated opportunities presented mentioned alternative solutions investigation provided answers studys research questions answers point use remote computer laboratories ideal choice resolve many current computer laboratory challenges experienced south african universities
disease congenital disorder characterized intestinal leading majority cases limited longer segment affected show many deviations retrospectively reviewed confirmed total cases single institution year period identify cases determine deviations known features eight cases found extended terminal lacked male contrast common females associated anomalies included congenital heart disease neonatal hypothyroidism previously associations clinical diagnosis often delayed average age diagnosis days diagnosis often made rather rectal biopsy histologically apart neural hyperplasia either absent focal diagnostic difficulty although number cases study limited due study still highlights spectrum deviations known clinicopathological features
expertise tends seen something people possess one needs knowledge skills competences able job better others various conditions practice objectively relevant knowledge expertise gets endorsed multi party settings different forms expertise tend compete one another latter certainly true construction sector parties different backgrounds interests work together order create maintain buildings works existing knowledge expertise need performed order get treated relevant business hand people one whose expertise treated salient differ across interaction settings make different phases project far however expertise treated relevant day day management construction projects effects thereof understudied argument put forward expertise research informed turn social sciences enrich construction management research agenda studies tend insight expertise ends treated relevant actual practice various positioned relative one another multi party settings insight existing expertise counts help developing strategies ensure expertise considered relevant practice optimally deployed future general directions provided expertise researched perspective construction
background excessive stiffness lower limb muscles associated sports injuries therefore identification reliable measurement shear elastic modulus various ankle flexion muscles required evaluate lower leg sports injuries study investigated reliable measurement shear elastic modulus ankle flexion muscles different ankle positions methods twenty three healthy young men years participated study shear elastic ankle flexion muscles including lateral medial posterior measured using ultrasonic shear wave degrees results reliability shear elastic modulus measurements ankle position assessed results showed reliability measurements differed ankle positions reliability shear elastic modulus measurements degrees higher degrees degrees conclusion results suggest measurements degrees provide reliable measurement shear elastic modulus ankle flexion muscles
study aims evaluate theory mind ability sample obese patients without binge eating disorder bed explore correlations emotional clinical assessments non bed threshold bed bed obese patients completed battery tests assessing social cognition eating disorder psychopathology eating disorder non bed threshold bed obese patients showed similar ability others emotions bed obese patients exhibited deficit emotions demonstrated impaired levels awareness depressed high positive correlations evident depression awareness eating disorder patients comparable ability understand others emotions impaired capacity understand code emotions compared non bed obese patients impairment highly correlated depression copyright john wiley sons ltd eating disorders association
purpose disordered weight management behaviors prevalent among youth recent case reports suggested behaviors also common transgender youth studied associations gender identity disordered weight management behaviors steroid use weight perception among transgender high school students methods data analyzed youth health survey anonymous survey random sample public high schools respondents divided three groups transgender male female fishers exact tests multivariable logistic regression models used examine unhealthy weight management behaviors past days fasting hours vomiting diet pill use use steroid use self perceived weight status analyses controlled age race ethnicity body mass index results compared males transgender adolescents higher odds fasting hours adjusted odds ratio aor confidence interval using diet pills aor taking aor transgender youth higher odds lifetime use steroids without prescription male respondents aor compared females transgender respondents higher odds perceiving healthy weight overweight obese aor conclusions transgender youth disproportionately self reported unsafe weight management behaviors steroid use compared youth clinicians aware increased risk among transgender youth research needed understand disparities inform future interventions society adolescent health medicine rights reserved
background associations thyroid diseases reported repeatedly objective investigated associations overt autoimmune thyroid diseases thyroid cancer using korean national health insurance claims database methods defined patients whose records showed physician contacts principal diagnosis also established age sex matched control group without per patient outcomes interest concurrent disease thyroiditis patients taking relevant thyroid medications thyroid cancer results study enrolled patients controls patients increased risks disease odds ratio confidence interval thyroiditis thyroid cancer compared controls associations consistently stronger males younger patients limitations individual clinical information available homogeneous population limit generalizability results conclusion significantly associated overt autoimmune thyroid diseases overt thyroid cancer
research examines implications consumers belief belief rewards right wrong context prosocial behavior although result greater intentions right supporting beliefs found facilitate prosocial behavior contexts associated series experiments shows strong weak beliefs actually respond less favorably rely common marketing tools meant enhance consumer responses also cue self gains offering incentives highlighting self benefits however effects obtained time represent means enhance social connections money consistent prosocial behaviors motivated self gains rewards lower intentions right among strong beliefs driven shift focused self focused attention following cue self gains compared results imply need take account consumers beliefs seeking prosocial behavior
paper construction use shared memory abstraction top asynchronous message passing system processes failures abstraction consists arrays single multi reader atomic registers number processes registers enable tolerance recording whole history values written one distributed algorithm building shared memory abstraction first presented algorithm assumes shown necessary sufficient condition construction hence algorithm resilient optimal paper presents distributed objects built top read write shared memory abstraction cope processes illustrated objects proposed shared memory abstraction motivated fact lot problems algorithms simpler design prove correct shared memory system message passing system elsevier inc rights reserved
paper reports investigation optimum design passive tuned mass damper system takes account soil structure interaction multi objective optimisation approach displacement velocity acceleration structure adopted three dimensional structural models five ten buildings resting soils different shear wave velocities used damper parameters calculated using three different approaches first damper tuned fundamental frequency fixed base structure second approach employs modified design parameters based third damper optimally designed using multi objective genetic algorithm results indicate taking effects soil structure interaction account leads performance improvements damper hand maximum value displacement soil structure damper system founded soft soil reduces considerable extent using genetic algorithm approach therefore simplicity efficiency using real coded genetic algorithm method optimal design tuned mass compared two approaches demonstrated
four lines commonly used auditory field label supporting cells expressed multiple subtypes lines also showing reporter expression hair cells hcs hypothesized altering dose modify expression target subsets also used two different reporter lines achieve goal results confirm previous reports expressed neonatal also hcs decreasing dose reduce expression changing reporter decreased reporter positive hcs however also significant decrease number reporter positive contrast large reduction reporter positive hcs mice lowest dose tested yet limited reduction labeling targeting reporter expression inner border cells increased paired reporter however total number labeled cells decreased changes dose reporter line caused minimal changes data demonstrate modifications dose use different reporter lines successful numbers types cells labeled line responded differently reporter combined four lines difference number positive cells one two injections given birth thus mediated toxicity reduced giving one injection reporter consistently labeled fewer cells reporter lines valuable depending goal study
letter present design two new high performing receiving antennas global positioning system gps layouts proposed based employment multiple order improve polarization purity pattern symmetry thus leading improved accuracy system first antenna configuration consists truncated corner squared patch rings miniaturized magnetic order suppress surface wave contribution reduce back radiation antenna second consists circular patch antenna four loaded number order improve front back ratio full wave numerical simulations presented show effectiveness proposed design terms impedance matching polarization purity antenna gain front back ratio shape radiation pattern
reactor utilizing low enriched fuel supercritical carbon dioxide coolant designed provide electrical power base reactor designed generate fifteen year operational lifetime electric output core alternating fuel elements nineteen coolant channels fuel element single coolant channel design uses enriched based fuel dioxide used coolant converts heat generated reactor electricity using closed cycle fuel used form hexagonal shaped elements coolant channels neutron moderator reactor uses based control control safety used thermal ensures moderator reach high temperature coolant channels prevent release gas fuel coolant used moderate reflect back active core active core eye configuration alternate fuel circular nuclear reactor modeling depletion analysis done using analysis found maximum factor occur core used determine greatest amount thermal power cores fuel elements experience provided basis thermal hydraulics sought determine maximum inlet outlet temperatures obtained also keeping reactor materials within acceptable temperature range maximizing temperatures provide highest performance power conversion system finding coolant conditions kept section core maximum temperature ensure rest core also remain within acceptable temperature limit simulations conducted different power levels fuel element generate throughout reactors fifteen year lifecycle thermal hydraulics done using research presents viable reactor design uses materials currently tested types reactors elsevier ltd rights reserved
ever growing prevalence dementia nursing costs increasing ability live independently ambient assisted living framework support independent living receiving intelligent clinical care integrates variety ambient wearable sensors together sophisticated interdisciplinary methods image semantic analysis semantic web technologies extensively employed represent sensor observations application domain implement hybrid activity recognition problem detection complete tailored user interfaces clinicians provided accurate monitoring multiple life aspects physical activity sleep complex daily tasks clinical problems leading adaptive non pharmaceutical interventions method already validated recognition performance improvement clinical level four home
hereditary angioedema hae autosomal dominant disease resulting deficiency inhibitor inh serine protease inhibitor plays regulatory role complement system contact system intrinsic coagulation cascade hae disease severity highly variable influenced genetic polymorphisms factors gender hormone mediated effects hae potential inadequate clearance immune complexes presence reduced levels components turn excess tissues results inflammatory damage release trigger autoimmune response reports link hae autoimmune conditions studies conducted large patient populations controversial results although several disorders documented prevalence defined autoimmune diseases patients hae remains debated occurrence autoimmune conditions hae patients disease severity enhancing complexity comprehensive care elsevier rights reserved
lymphoma usually forms solid tumours patients high expression levels adhesion molecules observed tumours however sarcoma associated related primary lymphoma form solid tumours adhesion molecule expression suppressed cells inoculation associated cell line peritoneal cavity severe combined immunodeficiency mice resulted formation solid lymphomas peritoneal cavity proteomics using two dimensional difference gel electrophoresis dna microarray analyses identified proteins genes respectively whose expression differed significantly solid lymphomas five genes identified similar expression profiles lymphocyte function associated antigen important adhesion molecule leukocytes among actin binding protein identified molecule showing high expression solid lymphoma dna microarray proteomics analyses western northern blotting showed predominantly expressed solid lymphomas moreover encoded proteins including viral interleukin highly expressed lymphoma compared solid lymphoma data demonstrate solid lymphomas possess distinctive gene protein expression profiles mouse model suggest differences gene protein expression solid lymphomas associated formation lymphoma invasive features solid lymphoma furthermore results obtained using combination proteomics dna microarray analyses indicate protein synthesis partly reflects correlate strictly mrna production copyright pathological society great ireland published john wiley sons ltd
funded national science foundation university spent last eight years developing implementing comprehensive educational robotics program youth ages program delivered informal school learning environments robotics provided robotics experiences youth educators goal project positively impact youths science technology engineering mathematics stem knowledge attitudes foster interest stem careers results extensive research evaluation showed youth participation robotics activities increased stem content knowledge particularly engineering computer programming perceived problem solving skills interest engineering careers youth also perceived robotics activities different school reporting robotics camp interesting involved hands activities elsevier rights reserved
three project consisted flood control engineering engineering transportation engineering electricity generation engineering culture engineering forth comprehensive water control project three project unity tangible culture human indicating high degree integration rich culture theoretical summary research perspective three project culture includes flood control culture scientific verification culture migration culture construction culture city culture transportation culture ecological culture culture film television art culture national image culture institutional culture tourism culture education culture complexity three project determines dual characteristics contains positive influence negative impact cultural three project china china rise greatly influences national merits makes surge relevant culture research philosophy mediation one day three project added national cultural heritage list world cultural heritage list just like irrigation system thus necessity time goes importance conducting research three project found
aim study examine independent impact various care pathways including involving intervention tri day discharge elective percutaneous coronary intervention hospital costs background associated costs billion annually alternative payment models implemented data exist strategies reduce costs various care pathways including tri exist association costs outcomes unknown methods total patients eligible national cardiovascular data registry registry linked medicare claims files analyzed hospital costs estimated using cost charge ratios propensity scores tri propensity adjustment via inverse probability weighting performed results procedures tri used used cases tri tri intervention associated lower adjusted costs confidence interval adjusted cost associated tri cost associated intervention non day discharge difference shifting current practice intervention non day discharge tri potentially save hospital performing year million country million annually conclusions among medicare beneficiaries tri independently associated fewer complications lower hospital costs findings important implications changing current care pathways improve outcomes reduce costs american college cardiology foundation
background recently calr gene mutations identified patients essential thrombocythemia high frequency cases without janus kinase mutations contain calr mutations exhibit clinical characteristics different mutant thus investigated frequency clinical features chinese patients han ethnicity calr mutations methods recruited chinese patients han ethnicity analyze states calr mutations polymerase chain reaction direct sequencing analyzed relationship mutations clinical features results calr mutations detected patients respectively mutation types calr involved deletion insertion base pairs type deletion type insertion mutations leading respectively three mutations exclusive clinically patients mutated calr lower hemoglobin level lower white blood cell count higher platelet count compared mutated furthermore significant difference found wild type patients triple negative mpl calr mutations patients mutations patients calr mutations predominantly clustered low intermediate groups according international prognostic score thrombosis conclusions calr mutations frequent chinese patients especially without mpl mutations compared mutant calr mutant showed different clinical manifestation unfavorable prognosis thus calr potentially valuable diagnostic marker therapeutic target
aim obesity associated development metabolic complications insulin resistance mechanisms leading remain unclear study aimed investigate relationship adipose tissue fibrosis obese patients bariatric surgery methods thirty five obese patients bariatric surgery type diabetes included study non diabetic patients classified either insulin sensitive insulin resistant based insulin sensitivity index model assessment used longitudinal evaluation insulin resistance fibrosis quantified staining microscopy mrna levels fibrosis related genes examined subcutaneous visceral adipose tissue biopsies collected months bariatric surgery results despite similar age body mass index fat mass fibrosis significantly higher diabetic insulin sensitive patients associated assessed baseline whereas fibrosis six months surgery significant weight loss fibrosis levels remained unchanged although significantly reduced groups correlation found fibrosis surgery conclusion overall results show significant likely transient association fibrosis obese humans elsevier masson sas rights reserved
empathy highly relevant social behavior expressed concern emotional empathy one mentally reconstruct understand another persons thoughts feelings cognitive empathy study investigated emotional effects neural correlates receiving empathic social responses negative performance feedback compared effects emotionally cognitively empathic comments participants male underwent functional magnetic resonance imaging receiving negative performance feedback cognitive task performance feedback followed verbal comments either expressing cognitive emotional empathy demonstrating lack empathy empathic comments general led less negative self reported feelings breathing neural level empathic comments induced activity regions associated social cognition emotion processing specifically right gyrus left cerebellum cognitively empathic comments right gyrus part left inferior frontal gyrus left middle temporal gyrus emotionally empathic comments orbital part left middle frontal gyrus left superior parietal gyrus emotionally empathic comments study shows cognitively emotionally empathic comments appear processed partially neural systems furthermore confirming expanding another study subject present results demonstrate social display cognitive empathy exerts almost positive effects recipients feelings emotions states distress emotionally empathic response relevant professional settings strong negative emotions need maintaining professional allow display cognitive emotional empathy elsevier inc rights reserved
paper presents theoretical framework intended accommodate circuit devices described characteristics involving two fundamental variables framework motivated recent appearance variety called devices circuit theory makes possible model coexistence memory effects different nature single device compact formalism setting accounts classical devices also circuit elements two variable description fully nonlinear characteristics allowed devices driving analysis beyond framework classify fully nonlinear circuit elements terms variables involved constitutive relations notions differential state order device extend notion configuration broader context characterize differential algebraic index nodal models circuits additionally explore certain dynamical features circuits involving non isolated related bifurcation phenomena explored family nonlinear oscillators based devices
paper mainly focuses conceptual design stealth performance three surface military aircraft three dimensional digital mock three surface stealth feature designed schemes carrying analyzed based physical optics principle method equivalent currents numerical simulation feature aircraft carried software designed university paper contributes feature analysis whole plane different parts band hand band comparison feature military aircraft drawn band pitch angle incident wave degrees result shows compared aircraft forward scattering three surface aircraft reduced side scattering back scattering compared aircraft forward scattering reduced side scattering paper useful researchers conceptual design stealth technology military aircraft
introduction nitric oxide modulates inflammatory reactions beneficial toxic effects depending concentration elevation cause proinflammatory effects inflammatory process participation cytokines smoking negative impact health considered one risk factors influence disease development facilitating inflammatory processes aim compare serum concentration cytokines smokers baseline months abstinence treatment methods blood samples collected obtain serum baseline months stored degrees analysis measured total dose nitrite determined method used technique determine concentration cytokines supernatants serum initial final results tnf alpha remained months treatment compared wilcoxon test used compare data spearman test correlations variables significance level adopted results analysis observed significant reduction initial median value mol mol months treatment significant differences cytokines baseline end treatment conclusion results mean harm body adaptive process decreasing metabolism due reduction use nicotine elsevier ireland ltd rights reserved
paper presents pid controller link voltage single phase switched boost inverter unlike link voltage controller source inverter presented controller directly controlled via capacitor voltage using controller constant capacitor voltage achieved input voltage load changed prototype built verify proposed controller simulation experimental results shown
decades independent morphological functional brain research key point neuroscience nowadays understand combined relationships structure brain components dynamics multiple scales ranging circuits neurons micro brain regions goal mind vast amount research focusing modeling simulating activity within neuronal structures simulations generate large complex datasets analyzed order gain desired insight context paper presents integrates set visualization interaction tools provide semantic view brain data aim improving analysis procedures provides particle based rendering allows visualizing simulation data associated spatial temporal information enhancing knowledge extraction process also provides abstract representations time varying magnitudes supporting different data aggregation operations giving also focus context clues addition tools provide synchronized control simulation analyzed finally allows performing selection filtering operations relying application called views coupled used independently also work together linked views centralized distributed computing environments enhancing data exploration analysis procedures
introduction phosphate bioactive derived activated platelet known induce diverse cellular responses least five protein coupled receptors various cell types abnormal platelet coagulation activation often seen patients gastric cancer however neither effects platelet derived mediator distribution receptors gastric cancer cell fully understood aim study examine possible role receptors progression gastric cancer materials methods characterized expression profiles receptors nine human gastric cancer cell lines evaluated relationship responses receptor expression cell migration modified chamber cell proliferation assay results northern blotting analysis revealed expressed gastric cancer cell lines varying degrees expressed four cell lines expression weak significant expression either detected addition markedly stimulated migration expressed effect inhibited toxin contrast significantly inhibited migration expressed exclusively indicates balance mediated signals critical determining metastatic response gastric cancer cells elicited weak significant effects three cell lines although effects major cells induced extracellular signal regulated kinase erk phosphorylation transient akt cause weak effects proliferation conclusions results suggest receptor expression critically determine biological behavior gastric cancers thus therapeutic interventions directed receptor clinically effective preventing metastasis gastric cancer elsevier inc rights reserved
objectives study examine effects activity program emotional intelligence prosocial behavior scientific investigation abilities attitudes total children aged years public private day care centers south korea participated session activity program program included indoor outdoor activities seeds plants making applying eco friendly fertilizer harvesting using plants make cooking produce designed improve emotional intelligence prosocial behavior scientific investigation abilities attitudes session lasted average minutes held per week results study showed session activity program improved emotional intelligence prosocial behavior scientific investigation abilities attitudes children satisfaction program high among children teachers parents future studies consider exploring effects activity programs children different age groups
medium large construction projects typically involve multiple structural use wide range structural analysis applications applications technologies inadequate interoperability still dearth investigations addressing interoperability issues structural engineering domain paper proposes novel approach combines industry foundation classes based unified information model number algorithms enhance interoperability architectural structural models among multiple structural analysis models bidirectional conversion round proposed approach aims achieve conversion overcoming inconsistencies data structures representation syntax used different software applications approach implemented client server server environments enable central remote collaboration among geographically dispersed users platforms tested four large real life projects testing involved four key scenarios bidirectional conversion among four structural analysis tools comparison conversion via proposed approach conversion via direct links among involved tools direct export based architectural tool application program interface api conversion visualization structural analysis results scenarios successfully performed tested four significant case studies particular conversion among four structural analysis applications ansys successfully tested possible conversion routes among four applications two case studies project project first four steps natural mode shapes natural vibration periods calculated compared converted models achieved within standard deviation project project respectively indicating accurate conversion elsevier rights reserved
background risk developing occupational contact dermatitis intense contact wet work combination chemicals objectives perform analysis cohort study occupational contact dermatitis recognized period focusing individual environmental factors associated disease methods study descriptive register based survey including recognized occupational contact dermatitis denmark period january september data obtained danish national board industrial injuries results study comprised patients women men median age years fully trained prevalence atopic dermatitis significantly higher among among fully trained respectively patients dermatitis recognized occupational contact dermatitis dermatitis recognized occupational allergic contact dermatitis combined allergic contact dermatitis recognized occupational contact urticaria conclusion low median age high percentages atopic dermatitis fact fully trained recognized occupational contact dermatitis importance early prevention
background polyphenol belongs class natural abundantly found red colored fruits skin red therefore current investigation intended evaluate effect myocardial infarction induced rats material methods effects assessed determining effect activities endogenous antioxidants catalase cat superoxide dismutase sod glutathione peroxidase gsh levels lipid peroxidation serum marker enzymes serum levels tnf alpha also determined using enzyme linked immunosorbent assay elisa kit result present study demonstrated significant effect restoring defensive activities endogenous antioxidants catalase cat superoxide dismutase sod glutathione peroxidase gsh reducing levels lipid peroxidation serum marker enzymes lactate dehydrogenase kinase significantly ameliorated histopathological changes impaired mitochondria cardiac necrosis stimulated additionally results also demonstrated nuclear translocation subsequent expression associated nuclear factor kappa kappa pathway activation conclusions findings suggest exerts effects due possible strong antioxidant anti inflammatory activities therefore study provides basis development safe effective treatment myocardial infarction
built locations road railway creates limitation flow passage furthermore commonly occurs flood events accumulation debris inlet inlet changes flow structure outlet result failure despite impacts hydraulics downstream received consideration literature purpose paper mitigate deficiency reporting investigation outlet partially blocked experimental tests conducted steady flow investigate relationship maximum depth ratio flow characteristics non blocked partially blocked conditions considered consideration results obtained showed area maximum depth increased partially blocked conditions compared equivalent non blocked
related rho reported activities endothelial cell biology angiogenesis metastatic melanoma corneal epithelial cells however less known inherently regulated comparison closest terminal extension amino acids comparison function amino acid sequence elucidated mutant lacking terminus found alter plasma membrane localization nucleotide binding additional point mutants mapped alterations biochemistry amino acids interestingly whereas mutant clearly influenced nucleotide exchange deletion terminus closest similar effect revealed amino acids contributed differences nucleotide loading together results identify amino acids within terminus loop region distal nucleotide binding pocket capable regulating nucleotide exchange thus influence membrane association protein
system presented mouse movement head position head used controlling horizontal vertical displacement closing activate right left system includes navigation vertical activation according position enhance functionality facilitate handling applications proposed solution eliminates restriction direct contact mouse people motor disabilities upper extremities interact computer mouse also used people without limitations expand command instructions system tested navigation social network facebook average speed pixels obtained average accuracy pixels axis pixels axis however user interaction interface improvements observed execution time location accuracy respectively activation temporary location option performance right left closing performance respectively finally surveys showed high satisfaction proposed interface user interaction facebook
parkinsons disease associated procedural learning deficits nonetheless studies demonstrated reward related learning comparable patients controls bdi brain science national academy sciences united states america however studies separate effect reward effect practice difficult determine whether effect reward learning distinct effect corrective feedback learning thus unknown whether group differences learning due reward processing learning general compared performance patients matched healthy controls hcs task effect reward examined separately effect practice found patients showed significantly less reward related learning improvements compared hcs addition stronger learning associations associations significantly correlated smaller skin conductance responses hcs patients results demonstrate separating effect reward effect corrective feedback patients benefit reward
background childhood emotional dysregulation connected chronic pain depression longitudinal studies exploring impact occurrence pain situation influence depression baseline pain situation treatment options course chronic pain clinical sample baseline data collected chronic pain patients first pain clinic visit follow data year self report questionnaires study variables consisted pain intensity pain disability depression bdi treatment interventions statistical analyses performed find differences baseline follow non patients estimate effect treatment follow majority patients pain intensity disability severe enough disrupt daily living none treatment interventions related better outcome patients reported pain disability depression baseline follow effect pain disability mediated depression use opioids connected depression made substantial contribution poorer severe pain intensity disability depression predicted difficulties achieving improvement depression probably impair compliance treatment adherence interventions occurrence severe pain situation use opioids indicates psychological problems underlying pain experience
objectives retinoic acid shown mediate potent effects respect extracellular matrix integrity study assesses effects combination cartilage catabolism methods animal human cartilage samples used assess ability promote release collagen fragments determined measuring respectively total tissue inhibitor inhibitory activities determined whilst gene expression matrix determined northern blotting immunohistochemistry used assess presence mmp cartilage explants results agents alone induced release bovine cartilage whilst induced collagen release variable reproducible synergistic observed appeared due mmp similar collagen release observed porcine cartilage conversely collagen release seen human articular cartilage primary human chondrocytes failed induce mmp caused significant increase expression conclusions novel observations show combination profound effects cartilage matrix turnover effects species specific better understanding mechanism combination differentially regulates mmp expression human chondrocytes provide valuable insight new therapeutic strategies aimed prevention cartilage destruction
viewpoints brazilian opinion leaders regarding cancer yet defined examining public perceptions three segments society qualitative study provide clues understanding negative view population still disease scientists teachers participated discussions six focus group sessions findings studied using content analysis method showing similar elements among professionals regardless area operation identified negative view contributing vision society associates illness death suffering although opinion leaders believe able filter certain negative aspects media dissemination cancer disease affects feeling resembles common sense words cure viewed prejudice hand morbid approach interest subject also noted disclosure cancer stands consumption news distortions support actions enhance communication cancer structured prevention early diagnosis cure
present study complex anti potential standardized concentrated solution pcs investigated using bilateral female mice changes body weight gain experimental periods food consumption serum estradiol levels total body abdominal fat densities abdominal fat uterus weights observed along histopathology abdominal fat uterus anti obesity effects addition liver weights serum aspartate aminotransferase alanine aminotransferase levels histopathological performed explore protective effects serum total cholesterol low density lipoprotein ldl high density lipoprotein triglyceride levels monitored effects total body femur mean bone mineral density bmd right femur wet dry ash weights strength serum osteocalcin bone specific alkaline phosphatase contents histological analyses anti osteoporosis activity result notable increases body weight gains food consumption abdominal fat mass densities weights abdominal fat deposited abdominal cavity serum ldl osteocalcin levels observed along decreases uterus liver femur weights mean total body femur bmd femur strength serum estradiol levels addition marked hypertrophic alterations adipocytes located deposited abdominal fat liver uterine changes decreases bone mass structures femur also observed control mice significant increases bone resorption markers based histopathological analysis however estrogen deficient symptoms significantly inhibited days continuous treatment estradiol pcs respectively present results suggested pcs able effectively inhibit refine symptoms including obesity hepatic osteoporosis induced mice
background somatic calr janus kinase receptor mpl mutations essentially show mutual exclusion myeloproliferative neoplasms mpn suggesting activate common oncogenic pathways recent data shown mpl function essential calr mutant driven mpn however exact role mechanisms action calr mutants fully elucidated methods murine myeloid cell line human cells overexpressing frequent calr type type mutants generated analyze first steps cellular transformation presence absence mpl expression furthermore mutant calr protein stability secretion examined using treatment results present study demonstrates expression endogenous mpl key transcription factor stimulated type type calr mutants even absence exogenous mpl mutant calr expressing cells spontaneously acquired cytokine independence associated increased mpl mrna expression protein constitutive activation downstream signaling response jak inhibitor treatment exogenous expression mpl led constitutive activation akt cytokine independent growth reduction apoptosis similar effects seen spontaneously cells observed low calr mutant protein amounts cellular stably cells due accelerated protein degradation occurred independently ubiquitin proteasome system autophagy calr mutant degradation attenuated mpl expression interestingly found high levels mutated calr loss downstream signaling secretory pathway protein glycosylation conclusions findings demonstrate potency calr mutants drive expression differentiation markers mpl furthermore calr mutants undergo accelerated protein degradation involves secretory pathway protein glycosylation
biologic therapies emerging significant therapeutic option many debilitating inflammatory autoimmune conditions expansion number fda approved agents continue seen adverse reactions likely occur currently diagnostic tools including skin testing vitro testing evaluate immediate hypersensitivity reactions insufficient review management strategies common acute infusion reactions injection site reactions immediate reactions suggestive ige mediated mechanisms discussed desensitization considered reactions suggestive ige mediated mechanisms involved managing patients
background constipation common condition affects many irrespective age since health care practitioners provided treatments prevention strategies patients chronic constipation despite significant variation medical personal perceptions condition objective review relevant research evidence clinical studies investigating efficacy safety commercially available pharmacological canada emphasis studies adopting rome criteria defining functional constipation search methods pubmed medline embase evidence based medicine reviews databases searched blinded randomized clinical trials meta analyses assessing efficacy treatment functional constipation results total clinical studies four meta analyses retrieved abstracted regarding study design participants interventions outcomes majority studies focused polyethylene glycol compared placebo provided better relief constipation symptoms placebo according objective subjective measures one study compared efficacy versus two reported changes quality life studies reported minor side effects due use regardless treatment duration ranged one week one year tolerated adults children
great part human communication carried information lost mobile text messaging work describes attempt augment text mobile phones adding automatically detected facial expression reactions conversations expressions detected using known image processing techniques known related work concerning investigation non verbal communication text messaging considered distinguished present solution conception implementation mobile phone application debated feature described user studies finally context application conclusions future work also discussed
neurologic complications observed half century little known however risk patients suffer migraine aura report case pediatric patient history migraine aura later found developed headache neurological symptoms
key responsible maintaining visual function vertebrates despite extensive research membrane bound fundamental questions regarding enzymology remain unanswered report crystal structure membrane like environment crystals obtained active protein displayed unusual arrangement wherein embedded lipid sheet structural differences uncovered key residues involved substrate uptake processing complementary iron edge ray absorption spectroscopy data established isolated contained iron center demonstrated presence tightly bound ligand consistent coordinated group results support hypothesis iron used promote ester dissociation generation intermediate required
study novel idea storing latent heat vapor solar means phase change materials thermal storage experimentally investigated daytime generated water vapor solar energy conducted external filled pcm latent heat absorbed pcm thereby stored worth direct contact saline water pcm therefore solar energy directly stored pcm evening energy stored pcm transferred heat saline water heat pipes enables process continue several tests run investigate performance system results revealed presence external filled pcm equipped heat pipes solar still tube collectors makes process continue without causing decrease yield daytime yield increases compared yield system without pcm reaches day efficiency elsevier rights reserved
purpose growing movement counter oral contraceptive united states study aimed explore womens views regarding age restriction methods november december administered nationally representative survey women aged years risk unintended pregnancy explore opinions age restriction total women completed survey weighted proportions calculated logistic regression used identify covariates associated supporting age restriction chi square tests potential advantages disadvantages access support age restriction also performed results overall respondents supported age restriction age restriction multivariable analysis controlling overall support access covariates women likely support age restriction less high school degree odds ratio high school degree college compared college degree married compared never married lived south compared west conclusions minority women support age restriction womens concerns potential addressed education ongoing research society adolescent health medicine rights reserved
paper presents design short term duty electrical machine working extreme environment consisting degrees ambient temperature higher power density key factor design wherein machines operation required short duty requirement high power weight power volume leads permanent magnet machine design optimized different slot pole combinations concentrated distributed winding arrangements considered optimization genetic algorithm used analytical electromagnetic thermal models adopted together finite element methods shown adopted thermal model provides sufficient accuracy predicting temperature rise within winding also shown designs thermally limited pole numbers limited drawn converter design consisting high slot number allows improving heat dissipation machine thus weight minimized given torque production
paper addresses problem robust infinity filtering design uncertain markov jump systems mode dependent output partly unknown transition probabilities data transmission exchange completed digital communication channel system outputs need transmission attention mainly concentrated tackling parameter uncertainty unknown transition probabilities output quantization parameter uncertainty considered paper assumed norm bounded exact information transition probabilities matrix partly unavailable quantization error output transformed bounded nonlinearity via model transformation mode dependent filter designed ensure filtering error system stable noise attenuation performance index finally simulation results provided illustrate validity proposed results elsevier rights reserved
results observations double multiple made national five presented ninth series measurements frames obtained also present results observations double multiple made station mountain fourth series measurements frames obtained station paper contains results position angle angular separation pairs pairs published orbital elements linear solutions angular range median angular separation also present eight pairs measured first time linear elements five pairs
paper maximum sensitivity internal model control based proportional integral derivative pid controllers designed unstable first order plus dead time processes designed controller parameters functions model parameters closed loop tuning parameter tuning parameter plays vital role determines closed loop performance robustness designed controller systematic guidelines provided selection tuning parameter based maximum sensitivity analytical tuning rules developed controller parameters different time delay time constant ratios desired level robustness controller settings allow operator deal closed loop control system performance robustness trade specifying robustness level maximum sensitivity simulation studies carried various processes explain advantages proposed analysis institution chemical engineers published elsevier rights reserved
account increasingly strict needs engine efficiency emission control fuel air ratio far control arrangements internal combustion engines still developed effects time delay limit far controller gains degrade system performance paper addresses control system design far suffer unknown time delay induced due several reasons unknown evaporation time unknown fuel quantity injected combustion process model used describe far relation surrounding factors affect combustion process new theorem proposed context depending technique manipulating poles cancellation control method achieve required control action mathematical proof introduced proposed theorem numerical simulation performed illustrate validity control scheme
observations suspension bridge show thermal expansion contraction cycles follow simple linear relationships single temperature value time lag temperature distribution significant factors investigation explores effects simulating transient thermal response bridge separate finite element models bridge suspension cables thermal loads determined calculated solar radiation intensities temperature data bridge monitoring system cloud cover plays important role levels solar radiation cloud coverage estimated indirectly using monitored temperature differences top bottom suspended structure results demonstrate peak temperatures suspended structure cables occur different times lag caused differing material properties surfaces ability absorb lose heat transient phenomena manifest structural responses tower doi american society civil engineers
review provides genetic major concepts lymphoma predisposition genomic instability immune deficiency inappropriate chronic antigen stimulation discuss syndromes mechanisms importantly review genetic counseling literature reveals sparse discussion genetically based immune mediated lymphoma predisposition address depth aim increase awareness among genetic colleagues oncology familial susceptibility facilitate critical thinking lymphoma risk assessment clinical application knowledge aided recommendations collection personal family history guide risk assessment testing lastly include special discussion genetic counseling issues including perceptions context nature magnitude lymphoma risk coping awareness susceptibility lymphoma
wastewater needs effectively treated minimize environment excellent pre treatment technology low content wastewater small oil droplets separation process complicated involves theories thermodynamics kinetics hydrodynamics despite numerous theoretical numerical simulation experimental investigations mechanism remains far fully understood paper uses cfd numerical simulation method research dynamic separation characteristics oil droplets including oil droplet diameter distribution mean diameter oil water separation efficiency different circulating flow rates corresponding different turbulent kinetic energy micro macro scale results showed oil droplet diameter distribution consistently changing separation process oil droplets improvement turbulent kinetic energies turbulence intensity effectively promote collision efficiency oil droplets accelerate oil water separation process turbulent kinetic energies turbulence intensity strong strong shear stress fluid promote oil droplets result decrease oil water separation efficiency circulating flow rate collision efficiency oil droplets strong enough shear stress fluid relatively weaker oil water separation efficiency reached highest numerical simulation results verified experimental results shows simulation results agreement experimental results micro scale macro scale indicates numerical simulation method cfd stable reliable elsevier rights reserved
concrete widely used building material thereby contributes growing cement demand constructions climate changes due global warming becoming important issue since cement industry responsible total amount carbon dioxide emissions world wide therefore researchers seeking sustainable alternatives solve problem large amount fly ash create new opportunities use waste substitute ordinary cement concrete production also produced reaction alkaline liquid materials containing reactive waste materials fly ash called new alternative green building material concrete production present paper going explore extended state art specifications use fly ash based concrete environmental impact mixture proportions manufacturing process last least long term properties fly ash based concrete
treatment management food processing waste major challenge food industry potato processing industry generates tremendous amount consider zero valued waste generated extraction sweet pulp considered waste properly utilized whereas waste utilized development biodegradable packaging film overcome environmental issues composite films prepared varying proportion potato powder sweet ratio ultrasound treatment min ultrasound treatment min ultrasound applied min film forming solutions break particles small enough form film films analyzed barrier mechanical properties observed increasing ultrasound treatment times gives better result film properties less content also gives better film properties observations film prepared showed better characteristics among films water vapor permeability moisture absorption water solubility strength elongation capacity film reported respectively however thermal decomposition film took place film forming solution selected film added essential oil antimicrobial agent stored days film successful lowering weight loss reducing hardness inhibition surface microbial load sample elsevier rights reserved
objectives expression patterns human epithelial neoplasms complex distinctive aims study analyze expression evaluate diagnostic application human non small cell lung cancer nsclc methods mrna expression analyzed northern blotting protein expression evaluated immunohistochemistry tissue microarrays results northern blotting showed highly expressed human bronchial epithelial cells small airway epithelial cells nsclc cell lines expression pattern heterogeneous regarding protein expression primary lung tumors expression proteins increased squamous cell carcinomas compared adc respectively higher expression significantly associated lower grading respectively increased expression observed adc respectively conclusions data suggest diagnostic value nsclc copyright karger basel
common method used minimizing occurrence diabetes complications frequent glucose testing adjust insulin dose however using blood glucose meters presents risk infection great importance develop non invasive detection techniques realize high accuracy low cost continuous glucose monitoring developed non invasive detection system using mixed signal processor microcontroller method based combination energy method sensor integration module physiological parameters blood oxygen saturation blood flow velocity heart rate new methods detect basal metabolic rate proposed combine human body heat balance characteristic signals dual elastic theory four hundred clinical trials real time non invasive monitoring suitable experiment conditions performed different individuals including diabetic patients senior citizens healthy adults information fusion model applied process samples algorithm defined algorithm applied model combines decision tree back propagation neural network physiological environmental parameters three categories establishes corresponding prediction model three categories algorithm provides accuracy predicting new samples thus system demonstrates great potential reliably detect values non invasive setting
use personal care products widespread united states tends greater among african americans whites special concern possible hazard absorption chemicals activity anti products exposure adverse health effects especially occurs developmental windows estrogen levels low assessed ethanol extracts eight commonly used hair skin products popular among african americans using cell proliferation assay estrogen sensitive mcf cell line derived human breast cancer four eight personal care products tested oil hair extra dry skin intensive skin petroleum demonstrated detectable whereas three placenta hair tea tree hair skin cream exhibited data indicate hair skin care products suggest laboratory studies warranted investigate vivo activity products chronic exposure conditions epidemiologic studies investigate potential adverse health effects associated use products
compute intensive applications gradually changed focus massively parallel capacity resource obtained demand particularly true large scale adoption cloud computing mapreduce industry difficult traditional high performance computing hpc usage scientific engineering computing exploit type resources however strong trend increasing parallelism rather faster processors growing number applications target parallelism already algorithm level coupled approaches based sampling formulated mapreduce highly amenable throughput computing many general powerful frameworks particular sampling based algorithms scientific computing clear advantages platform highly aware underlying physical problem present challenges addressed combinations programming peer peer techniques peer peer networks platform allows automation sampling focused workflows task generation dependency tracking least diverse set compute resources ranging clouds distributed computing across fragile networks workflows defined modules using existing programs makes without programming requirements system achieves handling node failures minimal loss computing time due single server manage hundreds thousands cores computational chemistry applications authors published elsevier open access article license
central often used suspension bridge improve bridges performance actual operation condition influence central natural vibration characteristics bridge deck driving comfort long span suspension bridge studied using case study suspension bridge china based finite element software ansys independently program influence central structure force applied characteristics long span suspension bridge explored results show huge increases natural frequencies result presence central increases bending torsional central basically makes cables within triangular area covered relatively approximate rigid area hence central reduce torsional displacement main girder however increases bending torsional little influence impact factor obtained using vehicle bridge coupled vibration analysis means central little effect comfort indices addition found central enhance bridge driving stability due decrease torsional displacements main girder
policies challenges integrating distributed generation resources recent electricity demand due economic crisis technological change led lower returns european electricity innovative sustainable business models needed serve electricity customers reflecting operational needs system maintaining financial viability paper describes novel model integrated energy services encompasses distributed generation demand response resources industrial customers reflect market opportunities regulatory drivers development similar schemes across europe elsevier ltd rights reserved
aims study aims evaluate lower urinary tract symptoms luts risk factors associated functional abnormalities women reporting adult onset secondary nocturnal help understand factors associated methods women age attending tertiary referral centre underwent comprehensive standardized evaluation including urodynamic testing accordance international society recommendations records patients reporting evaluated various categories multiple logistic regression used identify statistically significant risk factors urodynamic findings associated results prevalence women undergoing urodynamic testing luts high bmi cigarette smoking antidepressant usage neurological conditions previous significantly associated women significantly overactive bladder oab symptoms slightly higher mean nocturia episodes low maximum closure pressure detrusor overactivity incontinence doi significantly associated significant association symptom stress urinary incontinence urodynamic stress incontinence detrusor overactivity conclusion women adult usually present oab symptoms associated high bmi cigarette smoking antidepressant use neurological conditions doi low possible pathophysiological mechanisms wiley periodicals inc
research details development comfort interpersonal touch scale designed measure individual differences interpersonal touch tendencies preferences construct defined degree individual comfortable intentional interpersonal touch another person scale incorporates distinction initiating touch act someone receiving touch act someone investigation construct includes scale development measure purification validation initiating receiving within approach avoidance framework demonstrate comfort initiating touch related approach tendencies comfort receiving touch related avoidant tendencies avoiding spaces previous research generally finds positive effects interpersonal touch find effects least part depend individuals comfort interpersonal touch discuss theoretical managerial implications future research opportunities using scale society consumer psychology published elsevier inc rights reserved
green building construction considered essential practice achieving sustainability achieve sustainable development greater attention paid environmental social economic impacts associated construction operation buildings hence importance integrated approach green building design cost effectiveness gained momentum present study focuses developing appropriate constructs benchmark green building attributes construction limited sustainable performance building improved study indian green building assessment tools green rating integrated habitat assessment indian green building council eco housing newly developed rating system reviewed data analysis employed benchmark green building attributes buildings different climatic conditions hot dry warm humid composite climates chosen benchmarking purposes efficiency calculated using constant return scale input oriented formulation method following attributes observed utilization indian standard bis recommended waste materials building increase environmental awareness dedicated facilities service staff design universal accessibility low impact design construction management practices use low volatile organic compounds contribute green points lower cost elsevier ltd rights reserved
continues common consequence abdominal surgery causing significant patient discomfort often leading serious problems therapy available limited hence remains important clinical problem activation inducible nitric oxide synthase inos directly modulates intestinal bowel manipulation plays essential role initiating intestinal inflammation nuclear factor kappa known critical component inos gene transcriptional activation response inflammatory stimuli crude extract stem nutritional supplement promote digestive health anti inflammatory medication developed countries found oral administration improves decrease abdominal postoperative rats results showed increased wet weight dry weight water content number fecal plus mechanically manipulated rats suggesting improvement postoperative furthermore treatment inhibited overexpressed inos mrna restored regulated inhibitor kappa alpha mrna colon postoperative rats vitro experiments inhibits lipopolysaccharide lps induced nitrite macrophage cell lines lps induced kappa luciferase reporter gene expression macrophages transfected kappa luciferase reporter gene thus findings suggest improves decrease postoperative rats least part inhibiting colonic inos overexpression via kappa pathway data indicates benefit patients postoperative elsevier inc rights reserved
harsh service environment performance bridges even leads catastrophic collapse structural temperature widely recognized one negative environmental effects bridges structural responses deeply affected variation distribution temperatures bridges therefore identifying correlations significant issue structural safety assessment study relationships temperature induced static response surrounding weather factors investigated based long term field measurements long span suspension bridge correlations meteorological parameters bridge nearby weather station relations structural static responses air temperature investigated results indicate relationships meteorological parameters nearby weather station bridge field predicted correlation static responses air temperature remarkable high correlation coefficient conclusions expected provide reference design evaluation long span suspension bridges
objective examine value posttraumatic headaches predicting return work patients mild traumatic brain injury setting participants total participants recruited outpatient head injury rehabilitation center british columbia canada design logistic regression analyses secondary data main measure numerical pain rating scale measure headache intensity nine resulting scores used predict successful versus unsuccessful results largest effect size odds ratio value indicated odds returning work successfully cut half unit increase rating conclusion authors knowledge first study impact headache intensity patients posttraumatic headache severity taken account developing models predict population headache intensity act confounding variable least injury characteristics cognitive functioning add inconsistencies tbi literature results utilized guide rehabilitation efforts planning patients
propose ultra lightweight compact low power block cipher substitution permutation based network operates bit plain text supports key length bits compact structure requires gate equivalents bit key bit key cipher includes shift operators round permutation layers operations unique design helps generate large number active boxes fewer rounds linear differential attacks cipher shows good performance hardware software platforms consumes less power compared lightweight cipher led higher throughput compared existing network also present security analysis performance ultra lightweight compact cipher suited cipher design applications small footprint area low power dissipation play crucial role
background allergies frequently reported significant impacts upon appropriate prescribing clinical outcomes surveyed infectious diseases physicians clinical hospital pharmacists evaluate antibiotic allergy knowledge service delivery australia new zealand online multi choice questionnaire developed endorsed representatives society clinical immunology allergy society infectious diseases item survey distributed april members society hospital pharmacists australia royal college physicians respondents currently use antibiotic allergy testing reported seeing patients week labelled antibiotic allergic forty two per cent aware available felt aid antibiotic selection antibiotic appropriateness antimicrobial respectively patients histories immediate hypersensitivity likely referred delayed lack specialist physicians personal experience barriers service delivery multidisciplinary approach preferred model knowledge gaps identified majority rates cross reactivity high burden antibiotic allergy labelling demand complicated relative lack availability awareness services australia new zealand antibiotic allergy education deployment accessible community hospital based clinicians improve clinical decisions reduce antibiotic allergy impacts collaborative approach involving infectious diseases physicians pharmacists required
process model guidance important feature software process without guidance production lifecycle producing reliable software high quality standards usually teams break process application lifecycle management tools log teams even break process log file key discover behavior undertaken process targeted process model since date introduction process mining techniques used business process domains focus software engineering processes research brings process mining techniques software engineering domain research shows conclusive effort used adapted process model example agile adoption research applied process mining discovery techniques capture actually implemented process team application gap standard process guidance actually implemented one results showed process mining techniques ability discover verify deviation levels process work items state machine workflows
background intracranial present treatment challenge cases first line treatment always achieve cure gamma represents alternative treatment option purpose study evaluate utility methods reviewed cases treated institution independently following failed surgical management patients clinical files radiological images catheter surgical reports retrospectively reviewed results sixteen patients treated identified eleven aggressive five benign marginal doses ranged target volumes ranged symptomatic patients treatment resulted symptom lesions cure symptoms reported one lesion asymptomatic cure achieved eight cases small residual occurred four four unchanged one patient developed headache resolved one year hemorrhage occurred follow period significant association type cure rate prior failed treatment small target volume associated lower rates cure conclusions viable treatment effective symptoms novo approach adjunctive therapy experience somewhat effective achieving complete cure
post transplantation used graft versus host disease prophylaxis alone combination agents associated excellent rates acute chronic absence post transplantation disease study previously evaluated risk developing donor derived malignancy patients receive giving chemotherapy immediate post transplantation period carries theoretic risk graft time increased hematopoietic stress causing accelerating development malignancy patients underwent allogeneic transplantation received hospital cases identified among large population similar rate published literature found estimated cumulative incidence competing risk analysis use appear increase risk american society blood marrow transplantation published elsevier inc rights reserved
office buildings constitute significant proportion non residential building stock recent years various rating tools developed foster green office building development green building council australia developed green star office rating tools purpose increasing number stakeholders adopting tools efforts sustainable development research focuses challenges barriers obtaining ratings australian office buildings accomplish scoring sheets rating certified office buildings collected critically analysed findings indicated credits related attributes innovation ecology energy comparatively difficult achieve also found study large number projects apply specific credits global warming potential use fill removal site individual comfort control study provides useful reference property developer green building council australia green building developments future particular findings provide useful inputs development next generation green building rating tools
regression analysis machine learning approach aims accurately predict value continuous output variables certain independent input variables via automatic estimation latent relationship data tree based regression models popular literature due flexibility model higher order non linearity great conventionally regression tree models trained two stage procedure recursive binary partitioning employed produce tree structure followed pruning process removing insignificant leaves possibility assigning multivariate functions terminal leaves improve work introduces novel methodology node partitioning single optimisation model simultaneously performs two tasks identifying break point binary split assignment multivariate functions either leaf thus leading efficient regression tree model using six real world benchmark problems demonstrate proposed method consistently outperforms number state art regression tree models methods based techniques average improvement mean absolute errors predictions authors published elsevier ltd
aim work study effect high pressure processing main protein involved allergy results obtained showed pressure time combinations slightly enhanced vitro ige binding extract moreover additional tests carried means skin prick tests allergic patients different vitro results vivo effects evidenced mpa min either reduce increase depending particular patient variability highly remarkable skin response extract stronger half individuals results suggest higher risk treated products elicit reaction however also proved matrix plays important role modification consequently investigations needed results complex products industrial relevance allergy one frequent allergies mediterranean countries among adult patients however date information effect study increases understanding impact processing important fruit allergen order advance knowledge based ways managing allergens risks industry opens new opportunities research technologies strategies attempt reduce elsevier ltd rights reserved
people spontaneously produce gestures speaking thinking authors focus gestures indicate information related contents concurrent speech thought gestures previous research indicates gestures communicative functions also self oriented cognitive functions article authors propose new theoretical framework gesture conceptualization hypothesis explains self oriented functions gestures according framework gestures affect cognitive processes main ways gestures activate manipulate package explore spatio information speaking thinking four functions shaped gestures ability information focus small subset available information potentially relevant task hand framework based assumption gestures generated system generates practical actions object manipulation however gestures distinct practical actions represent information framework provides novel comprehensive account self oriented functions gestures authors discuss framework accounts gestures abstract content consider implications relations self oriented communicative functions gestures
mode fracture one three primary macroscopic fracture modes common tensile fracture mode crack direction normal applied stress micro cracks inclusions segregation second phases materials unavoidable affect directly strength materials hence stress fields mode crack tip became focus fracture type developed constitutive model taken account micro cracks inclusion etc materials model reasonably illustrated brittle fracture extend numerical analysis infinite plate mode crack employed model conducted completed paper help fem software length crack curvature tip crack dimensions plate subjected uniform stress two ends long wide material plate typical elastic plastic materials distributions stresses strains values damage tip crack obtained fem software process propagation crack completely simulated method element failure
background aims neonates born hepatitis virus hcv positive mothers usually screened hcv children act active sources social hcv transmission factors contributing vertical hcv transmitting still remained controversial needed optimization aimed investigate factors contributing vertical hcv transmission egypt highest hcv prevalence worldwide methods prospectively followed neonates born hcv positive mother child bearing period identify mother child transmission factors january march data mining computational analysis used quantify findings results among randomized pregnant women prevalence hcv hcv vertical transmission identified eight neonates high viral load identified predictor risk conclusions hepatitis virus pregnancy substantial risk vertical hcv transmission high viral load hcv positive women increases risk hcv transmission neonates screening pregnant women early stage pregnancy optimizing hcv viral load hcv positive women prevent vertical hcv transmission neonates
background atopic dermatitis characterized intense common childhood inflammatory disease many factors known affect development including pleiotropic cytokine yet little known regarding direct effects keratinocyte function objective methods report rna sequencing functional assays used define effect allergic environment primary keratinocyte function wound repair mice results acute chronic stimulation modified expression genes expressed human keratinocytes involved broad spectrum functions among induced changes repression critically impaired human keratinocyte wound response moreover mouse models spontaneous induced like lesions delayed importantly topical treatment restored epidermal repair response conclusion keratinocyte gene expression critically shaped altering cell fate decisions likely important clinical manifestations pathology allergic skin disease
alternative materials like recycling materials industrial products soils already influenced human activities urban soils commonly accepted building material constructions risk contaminant materials limited reducing amount water technical means achieve adapted requirements road construction research project aims better knowledge processes road constructed alternative materials different technical input behavior water contaminants used soils road runoff measured eight field urban road enterprise zone southern germany vehicles per day contains cut technical aim decrease include capillary barrier drainage layer geotextile second one gravel film modified mineral sandy gravel soil used construction cut four soils spiked low contamination test efficiency technical water road runoff value electrical conductivity concentrations chloride analyzed two week composite samples since july amount road runoff runoff water electrical conductivity measured continuously noted measures taken testing period order solve test set measures affected observations presented results show road runoff shows considerable concentrations also elevated concentrations expected former experience literature now types lead strong retention two substances however elevated concentrations found water times high chloride concentrations originating salt furthermore shown average contaminant relatively small measurement period changes concentrations parameters seem induced mainly high chloride content infiltrating road runoff time occurrence changes effluent temporal variations depend also soil type soil technical additionally seems soil type stronger influence process compared different technical possible reasons discussed published elsevier
process automation systems widely known crucial element processing plants power plants chemical oil refining food automotive many processes industry vast complex said controlled just major players worldwide computer control systems control engineering methods heart automatically controlled processes motivated practical success modern control engineering methods many industrial process consumer electronics products increasing amount work development new methods based new robust adaptive methods numerical optimization techniques soft computing strategies decentralized control structure hardware embedded controllers realization paper presents current state development currently widely used control methods structures applications different types automated processes objective paper survey compare performance conventional controllers several selected advanced controllers regard advantages drawbacks industrial applications
mammalian circadian timing system consists master nucleus time information various central peripheral tissues function circadian rhythm regulation extensively studied still limited understanding peripheral tissue clock function contributes regulation physiological processes adrenal gland plays special role context adrenal hormones show strong circadian secretion rhythms affecting downstream physiological processes time shown affect clock gene expression various tissues thus mediating systemic external promoting internal circadian alignment review discuss function circadian adrenal gland relay time day information tissues focusing glucocorticoids conclude impact adrenal rhythm disruption neuropsychiatric metabolic immune malignant disorders
although extent influences judgments committed remains unclear address knowledge gap participants high low provided ratings committed present study also examined extent judgments violations social differed function purity violation consistent predictions participants significantly higher ratings participants violations committed however two groups differ ratings violations committed findings also revealed difference violations committed greater violation contain versus present however pattern findings observed differences ratings lastly pathogen sexual moral mediated association moral purity ratings violations committed mediated effect observed ratings violations committed implications findings better moral perceptions discussed elsevier ltd rights reserved
leaf explants infected transformed agrobacterium tumefaciens plasmid construct contains mutated ethylene receptor gene arabidopsis thaliana control flower specific promoter eight putative transgenic plants exhibiting significant protein content showed lower ethylene sensitivity control plants ethylene exposure one transgenic lines line showed altered architecture infertility line lowest ethylene sensitivity line analyzed expression copy number gene crossed ethylene sensitive cultivar create progeny gene found expressed leaves confirming promoter induces expression flower specific manner southern blotting segregation data crossing pcr analysis progeny plants revealed two dna copies line fashion plants plants one dna copy ethylene resistant plants useful breeding confer ethylene cultivars
paper addresses dynamical behaviors switching van der circuits investigating stability issues autonomous nonlinear dynamical systems firstly kind nonlinear dynamical systems piecewise switching autonomous nonlinear system used formulate class van der circuits composed least two alternative electrical sub circuits secondly based concept system stability sense lyapunov continuously positive definite functions paper proposes two new necessary sufficient conditions stability asymptotic stability autonomous nonlinear systems based new stability results obtained paper present several criteria globally stability local instability unique zero equilibrium kind electrical circuits meanwhile existence uniqueness stable limit cycle also given switching van der circuit novel results obtained paper show switching actions involved van der circuits classical nonlinear dynamical phenomena relaxation oscillations finally numerical simulations several nonlinear systems switching van der circuit illustrate effectiveness practicality new results
humans diagnosed alcohol use disorder sensitive painful stimuli withdrawal suggests excessive alcohol drinking pain outcomes alcohol dependent rats exhibit increases sensitivity withdrawal data animal models suggest brain receptors mediate alcohol drinking tested effect alcohol dependence thermal rats ability acute alcohol antagonists reverse withdrawal alcohol dependent rats rats trained self alcohol tested baseline thermal half rats made dependent alcohol rats lateral ventricle tested effects acute alcohol drinking acute fixed dose alcohol intra ventricular related protein endogenous antagonist intra ventricular synthetic antagonist intra nasal withdrawal alcohol dependent rats relative non dependent alcohol naive controls alcohol dependent rats exhibit thermal abolished alcohol drinking alcohol intra ventricular intra nasal antagonists manipulations affect thermal non dependent alcohol naive controls suggesting alcohol dependence produces brain systems results suggest brain systems effective therapeutic target reducing alcohol dependent organism
gene cdna fungus overexpressed constitutive promoter line transformation achieved via agrobacterium tumefaciens insertion transgene verified pcr southern blotting transgenic expression approach used order investigate antifungal activity expressed antifungal activity detected transgenic using leaf assay lesion sizes transgenic caused significantly compared non transgenic plant
bending problem euler discontinuous beams classic topic mechanics paper beams internal springs addressed based theory generalized functions shown context closed form expression given functions due point forces based beam response arbitrary loads set boundary conditions proposed solution method presented regular course mechanics solids strength materials undergraduate students require advanced knowledge theory generalized functions knowledge basic concepts generally presented courses instance dynamics structures help students address simple effective way many engineering applications involving discontinuous beams
micrornas mirnas important modulators gene expression eukaryotic cells however rnas size bacteria specifically discussed previously provide library mirna size rnas registered deep sequencing streptococcus bioinformatic analysis whole set revealed individual species cellular content selected verified quantitative pcr northern blotting high abundance discrete size subset registered suggest functional significance although precise biological role rna species revealed one principle causative agents dental elucidated
purpose paper compare structural responses obtained stochastic analysis suspension bridge subjected uniform partially correlated seismic ground motions using different spatial correlation functions commonly used earthquake engineering spatial correlation function employed study consists term characterizes loss account spatial variability ground motions widely used four loss models literature taken account study models characteristics intended determine sensitivity suspension bridge due losses models represent spatial variability ground motions suspension bridge europe asia selected numerical example bridge steel towers flexible inclined steel box deck main span side spans european asian sides respectively ground motion filtered white noise model considered applied vertical direction intensity parameter model obtained using component dam record san earthquake analytically simple model called filtered white noise ground motion model chosen represent earthquake ground motion compared uniform ground motion case results obtained spatial variability models partial correlation outline necessity include spatial variability ground motions stochastic dynamic analysis suspension bridges observed largest response values obtained model proposed model proposed produces smallest responses among considered partially correlated ground motion models response values obtained uniform ground motion case usually smaller responses obtained partially correlated ground motion cases response values flexible parts bridge totally dominated dynamic component pseudo static component also significant contributions response values rigid parts bridge results also show consistency spatial variability models different characteristics considered study
pediatric migraine followed frequent episodes dizziness tension type headaches just children migraine show high sensitivity light noise also susceptible stimuli resulting dizziness previous studies found common among patients migraine migraine benign paroxysmal childhood identified common causes children without ear disease benign paroxysmal childhood also thought precursor later episodes migraine term migraine included part international classification headache disorders edition beta version increasing number studies shown positive relationship migraine however easily identified parents pediatricians young children unable explain migraine related symptoms also applicable specialists pediatric often know exact definition patients make correct differential diagnosis consequently inadequate evaluation treatment patients lead high socioeconomic cost review article discussing pediatric migraine help medical doctors effectively examine accurately diagnose treat young children suffering migraine
studies sexual relationships experiences quantitative focus characteristics individuals experience increase qualitative research revealed new insights experienced among young adults synthesize qualitative knowledge experienced qualitative carried using studies published june yielding seven conceptual categories opportunities choices regarding organized according context context peer norms expectations related lack communication emotional sexual commitment accountability implicit rules allowed maintaining boundaries sex emotion thus satisfy various needs related sex sex reported centred accessible improved experienced association however gender roles condom use sexual double standard gender roles limited womens agency enjoyment sex expectations lack communication developing feelings resulting self attempts suppress emotions partners hard time defining relationship time involved developing results indicate expectations rules experiences lack symbolic markers meaning status develop seen consequence complexity relationships
using online comments news stories context research used two experiments assess influence online comments peoples emotions perceptions others emotions study showed people perceived comments news stories greater effect negative emotions civil comments addition found people perceived comments greater effect negative emotions others compared self suggesting support emotional third person perception study showed people perceived agreement comments greater effect positive emotions comments findings also showed people perceived agreement comments equal effect positive emotions self compared others supports emotional first person perception elsevier ltd rights reserved
recognition facial affect studied extensively adults without traumatic brain injury tbi mostly asking match basic emotion words isolated faces method capture affect labelling everyday life faces context choices open ended examine effects context response format asked undergraduate students label emotions shown faces either isolation natural visual scenes responses representing basic emotions social emotions cognitive state terms used students responses create scoring system applied prospectively five men tbi groups responses neither basic emotion words significant difference response types faces alone scenes adults tbi used labels seen students responses overall often gave multiple labels one photo results suggest benefits moving beyond forced choice tests faces isolation fully characterise affect recognition adults without tbi
heat shock factor major heat shock transcription factor plays essential role mediating cellular response physiological environmental stress found lps induced expression colony stimulating factor csf gene upregulated knock mice using gene array order determine whether regulates induced expression csf mrna protein levels csf detected northern blotting elisa promoter csf analyzed online transcription element search system transcriptional activity csf promoter analyzed reporter gene assay results showed transcription protein secretion csf induced lps inhibited three high affinity binding sites enhancer binding protein beta heat shock element identified core promoter csf dna binding capability csf promoter reinforced lps influenced heat shock however observed bind binding sites csf promoter transcriptional activity csf promoter enhanced lps inhibited dose dependent manner conclude regulates expression csf binding binding element
chapter proposed robust cascade control scheme permanent magnet synchronous motor drive discrete time variable structure control considered rotor position speed obtained adaptive extended kalman filter performance filter improved line adjustment input measurement noise obtained suitably defined estimation algorithm proposed solution experimentally tested commercial drive equipped control system based floating point digital signal processor dsp
rapidly cancer cells synthesize greater amounts cholesterol build membranes cholesterol lowering drugs currently clinical trials anti cancer chemotherapy however given higher doses cause serious side effects inhibiting formation biologically important molecules derived alpha acts steps downstream potentially specific drug target portion pathway fully committed cholesterol production however screening variety commercial experimental inhibitors microbial revealed including clinical weakly inhibit human activity even display high apparent spectral binding affinity one relatively potent compound ethyl phenyl identified tested cellular experiments found decrease proliferation different cancer cell types crystal structures human complexes display inhibitor enzyme provide molecular insights regarding broader substrate profile faster catalysis weaker susceptibility human inhibition outline directions development potent inhibitors human alpha target anticancer chemotherapy towards structure aided drug design
age related alterations human gut microbiota composition thoroughly described detailed functional description intestinal bacterial coding capacity still missing order elucidate contribution gut complex mosaic human longevity applied sequencing total fecal bacterial dna selection samples belonging characterized human ageing cohort age related trajectory human gut microbiome characterized loss genes fatty acid production overall decrease potential proteolytic functions abundant intestinal younger adults altered functional profile associated relevant enrichment opportunistic proinflammatory bacteria generally present adult gut ecosystem low numbers finally signature long life identified microbial genes significantly correlated ageing collectively data emphasize relationship intestinal bacteria human metabolism modifications gut microbiota consequence promoter physiological changes occurring human host upon ageing
used agricultural practice throughout world effect due ability inhibit acetylcholinesterase activity long history use little information available respect metabolic fate disposition mammals present study designed investigate comparative vitro metabolism human rat mouse liver microsomes respectively characterize specific enzymes involved metabolism particular reference human metabolism metabolized cytochrome cyp leading production one major ring oxidation metabolite two minor metabolites affinity cyp enzymes involved oxidation significantly less intrinsic clearance rate calculations indicate fold less efficient metabolism screen major human cyp isoforms metabolic ability respect metabolism demonstrated major isoform responsible oxidation humans much less active human cyp isoforms minimal activity toward contrast human isoforms members family rats likely primary role metabolism normalization data average levels cyp native indicates metabolism primarily mediated percent total normalized rate although play ancillary roles respectively substantiated fact specific inhibitor excellent inhibitor formation irreversible non competitive inhibitor inhibits formation use demonstrated individuals high levels greatest potential major metabolite variation metabolism among single donor samples fold best correlation cyp isoform activity metabolism observed interaction substrates testosterone estradiol also investigated testosterone metabolism activated however less activation observed metabolism testosterone interactions estradiol metabolism observed elsevier ireland ltd rights reserved
hypothalamic pituitary leads low bone turnover followed bone loss reduced biomechanical properties sheep investigate role peripheral hormones centrally induced systemic bone loss model planned hormone replacement experiment therefore estrogen combination substituted ovariectomized sheep hormones decreased sheep known significant yet fully understood impact bone metabolism bone turnover structural parameters analyzed comparison different control groups untreated sheep ovariectomized ovariectomized sheep performed analyses nine months procedure biomechanical testing studied sheep low bone turnover led significant bone loss treatment alone mainly increased bone resorption leading reduction bone volume contrast treatment estrogen alone combined treatment estrogen prevented induced bone loss completely conclusion peripheral hormone substitution able prevent induced low turnover osteoporosis sheep treatment estrogen alone combination able completely preserve bone mass structure findings demonstrate importance peripheral hormones balanced bone remodeling physiological bone turnover elsevier ltd rights reserved
background purpose grading system utilizes skin changes generate individualized objective estimate cumulative lifetime ultraviolet radiation exposure however predictors grade defined particularly older populations aim cross sectional study describe factors associated skin damage measured method community dwelling older adults methods study participants aged years taken hands graded method lifetime sun exposure skin phenotypic traits smoking status assessed questionnaire density measured using respectively ordered logistic regression used compute single odds ratio taking grade outcome variable results higher associated increasing grade adjusted analysis age occupational sun exposure ability density lifetime leisure time sun exposure current smoking propensity waist hip ratio independent predictors grade hair colour number body mass index gender independent predictors grade conclusions skin cast grade biologically relevant marker exposure older adults influenced intrinsic extrinsic factors
manuscript presents method model detail piezoelectric traveling wave rotary ultrasonic motor stator response action voltages stator modeled discrete two dimensional system equations using finite volume method order obtain accurate results model stator bridge included stator model model stator action voltage presented first results model compared versus similar model using commercial finite element software one observe difference less displacements stator using proposed model one model stator action voltages presented time domain analysis shows generation traveling wave stator surface one use model accurately calculate stator surface velocities motion stator surface amplitude shape stator traveling wave system equations discretized finite volume method easily transformed electrical circuits better choice develop model based control strategy elsevier rights reserved
background individuals autism spectrum disorder asd show relative human voice accordingly typically developed peers adults autism show preferential response superior temporal lack voice specific response previously linked atypical processing electroencephalography slow event related potential erp called temporal positivity voice larger vocal non vocal sounds resulting voice sensitive response right temporal sites investigated neurophysiological correlates voice perception children without asd methods sixteen children autism age matched typically developing children heard vocal speech non speech non vocal sounds activity recorded overall smaller group children asd erp amplitudes compared using non parametric statistical tests electrode successive time windows within group differences conditions assessed using non parametric test post stimulus inter group comparisons erp amplitudes performed using non paired tests post stimulus results typically developing children showed classical voice sensitive response right temporal electrodes speech non speech vocal sounds children asd show preferential response vocal sounds inter group analysis showed difference processing vocal sounds speech non speech significant differences processing non vocal sounds right temporal sites conclusions results demonstrate lack voice preferential response children autism spectrum disorders contrast observations adults asd lack voice preferential response attributed atypical response non vocal sounds overall similar event related potentials evoked vocal sounds groups result suggests atypical maturation processes asd specialization temporal regions voice processing
learning objectives participating activity learners better able evaluate evolution social cognitive abilities developmental process assess evidence regarding social cognition difficulties youth clinical high risk psychosis individuals clinical high risk psychosis exhibit broad range difficulties including impaired social cognition represent target early identification intervention several studies examined various domains social cognition individuals focus adolescent young adult populations given accumulating evidence impairment exists onset psychotic disorders critically important begin look risk markers younger children present article reviews studies examine following four domains social cognition emotion processing theory mind social perception attribution bias eligible studies identified comprehensive literature search conducted using electronic databases including pubmed medline psycinfo combinations key social cognition search terms despite mixed results existing literature establishes individuals display social cognitive impairment though remains unclear impairment develops thus using literature social cognition typically developing children model reference looking evolution social cognitive abilities developmental process review presents valuable new perspective indicates necessity investigation younger risk populations implications treatment future research discussed
alpha synuclein protein involved pathogenesis including parkinsons disease dementia lewy bodies multiple system atrophy investigated role neuronal alpha myelin composition abnormalities phospholipid content purified myelin determined nmr two mouse lines modeling alpha alpha significantly higher levels detected myelin purified brains alpha transgenic mouse models control mice nevertheless myelin appeared intact investigate effect alpha myelin abnormalities systematically analyzed striatum brain region associated neurodegeneration age loss myelin basic protein signal detected immunohistochemistry striatal patches age dependent loss signal associated lower levels addition found alpha inhibited maturation formation sheets vitro based results concluded neuronal alpha involved regulation maintenance myelin phospholipid however axonal models evident progressive stages disease associated alpha toxicity
aiming support school based outdoor learning opportunities paper extent neo helpful highlighting personal growth practical gains necessary signs implementation gap practice policy made worse lack conceptual clarity educational achieved habit forming social emphasis learning problem solving reviewed prospects neo conception human moral sensitivities considered concerns often ideas educational thoughts rather cognition relative emotions also addressed article concludes suggestions neo ideas learning inform curriculum planning pedagogical practices
attracting new important issue destination marketing also imperative manage experience post trip particularly cases experiences yet questions tourism experiences received little attention tourism scholarship present research investigated effectiveness different forms marketing messages role thinking ability marketing message improve attitudes towards destination intentions recommend tourism experience satisfaction scenario based experiment conducted respondents results showed user generated messages messages employing emotional appeal destination generated rational messages respondents engaged downward thinking situation experience worse shown greater positive effect elsevier ltd rights reserved
landscape restoration performed two coal mine located spain demonstration pilot program restoration coal mine terrestrial used monitor process alternative use secondary plants physico chemical indicators soils study analyzes usefulness terrestrial different taxonomic levels orders families species restoration indicators initial restoration stages terrestrial respond rapidly restoration results explained short term increase abiotic factors resulting applied techniques mainly animal origin organic matter added biodegradable geotextile relatively low value short term restoration indicator specific level provided best information interpreting ecological results short term best relationship cost identification likewise results showed landscape restoration leads abnormal short term excessive abundance clear convergence appeared toward terrestrial communities present semi natural areas used reference end point restoration indicator value produced higher taxonomic levels studied terrestrial useful cost effective assessing short term changes caused environmental performed recover ecosystems affected mining activities copyright john wiley sons ltd
researchers interested psychological factors affecting higher education institutions academic concerned internal variables affecting writing productivity however empirical studies explore factors samples students process degrees graduate students study examined writing anxiety self efficacy emotional intelligence sample graduate students large research intensive university united states using survey collected measures variables addition demographic information participants used measures compare groups students similar characteristics run three regression models identify variables best predicted writing anxiety findings indicate self efficacy statistically significant large predictor writing anxiety though descriptive data showed moderate effects first language whether student reported english first language presence self efficacy gender remained significant predictor writing anxiety first language discuss implications future research practice focused helping graduate student academic succeed
operating conventional system heavy industries wire leads wire aging short life cycle occurs catastrophic damage whole system aim work investigating tension control system using magneto rheological brake provide back tension prevent frequent part changes fatal order achieve aim basic first designed analyzed using finite element method fem electromagnetic field fluid analysis performed second step prototype fabricated optimized structural parameters experimental apparatus constructed moreover output torque characteristics designed various input current rotational speed evaluated consequently conventional proportional integral derivative pid controller designed tension control control results show feasibility tension control system
effects hydrologic cycle change caused human activity global climate change ecosystems attract increasing attention around world result three dam climate change sand mining dry season lake lake chinas two largest freshwater lakes came early primary cause increasing need dam construction store water lakes attracted increasing attention paper compared landscape pattern three hydrologic years early dry season three normal hydrologic years lake remote sensing technology reveal effect early dry season landscape pattern results showed early dry season caused expanding zone lake caused expanding zone expanding zone lake landscape level significant difference landscape grain size landscape grain shape habitat connectivity landscape diversity two lakes habitat class level significant changes area grain size lake area grain size grain shape lake changes impact birds east asian migratory yangtze river elsevier rights reserved
paper proposes computationally efficient novel superior nonlinear controller existing trajectory orientation control problem robot first position orientation pose estimation robot obtained utilizing kinematic relationships multi sensor fusion techniques dynamic relationships robot used form state space representation nonlinear state space representation linearized identifying controlling nonlinearity causing states linearized utilized derive state feedback controller proportional derivative integral pid controller carry tracking task performances derived controllers evaluated simulation level comparing standard nonlinear controller two proposed controllers best performing state feedback based controller able successfully implemented low cost hardware platform due computational efficiency
important technique recover waste heat engine exhaust reduce emission paper presents parametric study diesel engine based analytical model analytical model developed investigate influence system parameters engine fuel consumption model based thermodynamics knowledge empirical models consider impacts parameter independently effects turbine efficiency back pressure exhaust temperature pressure ratio engine speed recovery energy pumping loss engine fuel reductions studied results show turbine efficiency exhaust temperature back pressure great influence fuel reduction optimal power turbine expansion ratio however engine operation speed little impact fuel savings obtained interaction mechanism recovery power engine pumping loss presented paper due nonlinear characteristic turbine power optimum value expansion ratio achieve largest power gain end fuel saving potential high performance engine requirements proposed paper elsevier ltd rights reserved
background data population based cancer registries generally considered gold standard confirming incident cases cancer available current information needed hospital routinely collected population level data feasible alternative sources aimed determine validity various methods using routinely collected administrative health data incident cases colorectal lung cancer participants study new south australia methods participants study recruited incident colorectal lung cancers assessed using diagnosis treatment records linked administrative health datasets hospital emergency department medicare pharmaceutical claims death records compared via cancer registry gold standard period data sources available participants results total colorectal lung cancers recorded study participants period diagnosis primary cancer recorded admitted patient data collection identified majority colorectal lung cancers sensitivities positive predictive values colorectal cancer lung cancer respectively using additional information lung cancer deaths death records increased sensitivity lung cancer improve colorectal cancers hospital procedure codes colorectal cancer surgery identified cases sensitivity individual indicator sensitivity either cancer type combination indicators increased sensitivity achieved using hospital cancer diagnosis data specificities close confidence intervals sensitivity generally conclusions identifying new cases colorectal lung cancer administrative health datasets hospital records feasible alternative cancer registry data available however strengths limitations different data sources borne mind
overcome productivity challenges encountered construction projects electrical contractors often apply reactive measures paper recommends electrical contractors use proactive measure enhance projects performance current advancements information technology made feasible contractors adopt construction methods incorporate components within projects limited information available current state use electrical construction industry qualitative data electrical contractors united states canada collected qualitative data analyzed understand impact use project performance perceived electrical contractors examined data revealed use significantly increased last decade electrical contractors perceive offers competitive advantage market use enables contractors reduce labor construction process performing activities parallel findings within paper indicate widely used multiple electrical activities implementation often results cost schedule savings increased labor efficiency addition found use usually results project quality improvements finally future trends indicate users planning effort improving practices within companies developing training programs personnel establishing protocols working american society civil engineers
coatings based chitosan applied layer layer technique preserve quality prolong shelf life fresh cut dried cut side fresh cut fruit coated using four treatments packed polyethylene containers stored degrees fruit used control application layer layer decreased weight loss fall total soluble solids content color effective delaying microbiological analyses demonstrated effectiveness layer layer microorganisms effective controlling microbial levels sensory analysis demonstrated layer layer helped preserve quality properties color texture overall acceptance conclusion layer layer based improved quality prolonged shelf life fresh cut six days compared control elsevier rights reserved
study examined feasibility using quantitation augment interpretation pet amyloid imaging total physician readers trained quantitation pet images principles using quantitation augment visual read day readers completed visual read scans autopsy verified patients seeking diagnosis day readers scans interpretation quantitation method using one three commercial software packages subset readers scans day based visual read control autopsy verified scans modified plaque score used truth standard interpretation accuracy autopsy truth standard available scans patients seeking diagnosis majority interpretation three readers best accuracy interpreting autopsy verified scans used reference standard day visual read accuracy high autopsy verified scans scans patients seeking diagnosis accuracy improved visual read read day accuracy interpreting autopsy verified scans also increased first second visual read group however agreement reference standard best readers scans patients seeking diagnosis improve second visual read cohort group significantly improved relative group change results indicate augmentation visual interpretation pet amyloid images quantitative information obtained using commercially available software packages reduce accuracy readers already performing average accuracy visual read improve accuracy confidence readers clinically relevant cases
article discusses automated test complex based devices basis monitoring parameters functioning integrated opamp radiation experiments need measurements input signals high accuracy support specified
stem cells fundamental human life offer great therapeutic potential yet biology remains incompletely cases even poorly understood field stem cell biology grown substantially recent years due combination experimental theoretical contributions experimental branch work provides data ever increasing number dimensions theoretical branch seeks determine suitable models fundamental stem cell processes data describe application population dynamics biology amongst oldest applications mathematics biology population dynamics perspective continues offer much today describe impact perspective made field stem cell biology using hematopoietic stem cells model system discuss approaches used study key properties capacity self renewal differentiation cell fate lineage choice also discuss relevance population dynamics models stem cells cancer competition naturally emerges influential factor temporal evolution cell populations
harnessing nonlinear optical effects photonic chip scale proven useful number key applications optical communications microwave also benefit adoption technology creating new concept nonlinear integrated look potential using nonlinear optical effects chip scale enable signal processing enhanced performance review number recent results field particular focus creation frequency agile high suppression microwave filters using chip stimulated scattering also discuss future prospect nonlinear integrated enable general purpose programmable analog signal processor compact high performance active microwave filters enhanced energy efficiency
whether children share anticipation future benefits returned partner interesting question study year old children adult partner played sharing game children first partner experiment partners resources attractive childs reciprocal condition child recipient partner played donor non reciprocal condition however child anonymous child recipient partner results showed children shared partner knew recipient later experiment child always recipient partner partners resources desirable childs high value condition less desirable low value condition found children partners resources valued higher findings demonstrate year old preschoolers sharing choices take account anticipated recipient suggesting either self interested sharing direct advance receiving specifically adjust sharing behavior depending whether partner potential whether worth sharing relative value payback
objectives present study aimed investigating effectiveness tolerability extended release major depressive disorder mdd patients atypical features methods patients prescribed weeks visits screening baseline weeks primary efficacy measure change structured interview guide hamilton depression rating scale seasonal affective disorder version sad baseline endpoint secondary efficacy measures included sad atypical symptoms subscale clinical global impression severity disability scale sds sleepiness questionnaire response remission defined reduction sad total scores respectively end treatment results total score reduced baseline end treatment atypical symptom subscale scores also reduced baseline end treatment end treatment subjects classified responders respectively frequently reported aes headache dry mouth dizziness conclusions preliminary study indicates beneficial treatment mdd atypical features adequately powered randomized double blind placebo controlled trials necessary determine results
novel label free system sensitive fluorescent detection activity developed utilizing dna silver graphene oxide dna nanocomposite first synthesized around rich template dna resulting dna binds interaction extension dna resulting dna show quite reduced fluorescence signal fluorescence dna presence however dna strand within dna rna hybrid probe employed study consequently releasing rna complementary extension dna released free rna extracts dna extension dna bound process restore fluorescence emitting highly enhanced fluorescence signal employing assay principle activity reliably identified detection limit lower previous fluorescence based methods finally practical capability assay system successfully demonstrated use determine activity bovine urine elsevier rights reserved
home health care workers interventions implemented western countries improve health status patients respiratory diseases especially asthma allergic illnesses twenty six controlled studies dealing prevention control diseases home environmental interventions reviewed comprehensive description characteristics studies effectiveness intervention evaluated terms participants compliance intervention program improvement quality indoor environment finally improvement health outcomes detailed tables limitations biases studies also discussed overall review aims giving toolbox home health care workers target appropriate measures improve health status patient depending environment disease case case approach achievable measures warrant efficacy home interventions review also provide research community tool better identify targets focus future evaluation studies home health care workers action american academy allergy asthma immunology allergy
mobile cloud computing emerging paradigm provide support demanding tasks resource constrained mobile devices relying integration remote cloud services research field tackling multiple conceptual technical challenges full realization networked autonomic machine framework tool supports facilitates design networks hardware software autonomic entities providing consuming services resources framework applied particular scenarios paper focus features related key aspects particular concerning code mobility capabilities autonomic strategies first contribution definition set high level actions supporting second contribution proposal formal semantics actions provides core features precise formal characterization thus third contribution development conceptual framework particular partial engineering related java middleware show effectiveness revised middleware discussing implementation global ambient intelligence case study
recent developments understanding role bile acids signalling molecules human metabolism inflammation opened new avenues field research longer considered simple molecules helping fat digestion agents real therapeutic value treating complex autoimmune metabolic liver diseases receptors receptor transmembrane protein coupled receptor activated receptor identified novel targets drug development novel pharmaceuticals already clinical evaluation advanced drugs reached phase iii trials chronic liver diseases primary primary fatty liver disease limited pharmacotherapy likely gain developments review discuss recent relevant basic clinical research findings related implications novel therapy chronic liver diseases
thirteen percent individuals african express two variant copies gene encoding apolipoprotein associated increased risk end stage renal disease general population limited studies suggest survival transplanted kidneys donors expressing two risk alleles inferior kidneys donors zero one risk allele living kidney donation two case reports describe donors expressing two risk alleles developed given potential impact variants utility safety kidney transplantation living kidney donation american society transplantation meeting goals summarizing current state knowledge respect transplantation identifying knowledge gaps studies address gaps considering approaches integrating clinical practice authors recognize current data sufficient support traditional evidence based guidelines also recognize require several years generate necessary data thus approaches currently integrated clinical decision making process considered report summarizes groups
view practical application problems traditional parallel processing technology existing processing massive data using powerful cloud computing power efficient massive data processing method combined advantages real time access relational database based hadoop distributed computing framework using map reduce framework author designs implements massive data processing platform based cloud computing practice proved system superior traditional parallel processing technology computing power stability scalability aspects effectively solve large concurrent access massive data many industries institutions rapid batch processing large data sets large medium sized databases data wide range application requirements realize fast interactive batch processing massive data increasingly prominent problem management information system also key problem solved engineering data sets traditional data platform based parallel processing unable meet actual requirements massive data processing architecture massive information technology urgently needs dynamic scalable storage calculation model order achieve rapid response mechanism large scale database data query analysis extraction updating batch processing processes facing serious practical problems first traditional database complex query time long faced query task large amount data even complete second system faced data task performance system drastically reduced third traditional database poor additionally hardware effectively improve performances system processing fourth cost massive data retrieval processing high high maintenance cost researches massive data processing technology time high efficiency effectively improve application performances computer system provide better social basic services promote growth economic efficiency new business computing model based internet cloud computing provides flexible computing capability efficient method processing massive data author paper applies cloud computing massive data processing relational database designs builds massive data processing platform based cloud computing provides new method solution processing massive data relational database
study aims detailed morphological changes thoracic part sympathetic trunk sheep fetal development bilateral micro dissection thoracic sympathetic trunk performed sheep fetuses aged weeks males females ganglion observed sides composed cervical first thoracic ganglia sides cervical first two thoracic ganglia sides presence two last thoracic ganglia constant influence sex side body ages fetus morphology topography thoracic sympathetic trunk sheep identified spite differences morphology topography thoracic sympathetic trunk early late fetal developments morphology topography older fetal thoracic sympathetic trunk tended similar adult sheep comparative morphology fetal thoracic sympathetic trunk completely results compared previous studies consequently differences similarities composition position presence single cervical ganglion without fusion thoracic ganglia absence thoracic ganglia presence splitting branch found among sheep pig human fetuses therefore sheep appropriate animal model applied human sympathetic nervous system elsevier rights reserved
multifunctional control strategy single phase cascaded bridge multilevel inverter suitable microgrid systems nonlinear loads presented primary advantage produce output voltage low harmonic content utilizing unequal voltages individual bridge cells grid connected mode operation control strategy based conservative power theory providing selective current compensation besides available energy autonomous mode operation two different control methods along damping resistor filter circuit developed regulation instantaneous output voltage variety load conditions first method single loop voltage control scheme without need current measurement second one voltage control scheme load current feedforward compensation strategy preservation grid connected current control scheme steady state response stability voltage control schemes analyzed based application requirement control schemes implemented individually effectiveness control strategy experimentally verified using hardware loop setup control algorithm implemented dsp microcontroller
fundamental concepts biochemistry important drug design often lack connection macroscopic world difficult students grasp particularly introductory science courses high school college level educational research shown teaching facilitates learning teaching high school college level almost exclusively limited visual auditory approach lifetime experience students bring classroom form taste perception makes teaching less supportive sensory impairment article outline novel guided inquiry activity utilizes taste perception series natural artificial solutions introduce concepts substrate affinity selectivity context drug design findings study demonstrate clear gains student knowledge increase fields biochemistry drug design international union biochemistry molecular biology
diagram family clusters points plane distance point cluster measured maximum distance point diagram defined nearest neighbor sense input clusters paper consider non crossing clusters plane combinatorial complexity diagram linear total number points convex clusters present randomized incremental construction based point location computes diagram expected time expected space techniques efficiently handle non standard characteristics generalized diagrams sites non constant complexity sites regions empty regions diagram finds direct applications computer aided design
diagnostics cornerstone practice infectious diseases however various limitations frequently lead unmet clinical needs domains diagnostics focus defined questions provide readily answers use true gold standards development contrast infectious diseases diagnostics scores potential pathogens clinical syndromes emerging pathogens rapid evolution existing pathogens associated resistance mechanisms absence gold standards many situations spite challenges importance value diagnostics underestimated therefore antibacterial resistance leadership group identified diagnostics major areas emphasis herein provide overview development highlighting several examples innovation study design content execution advancing field infectious diseases diagnostics
marine green found sensitive sensitivity test indicating employed selective agent bar gene marker gene vector containing expression cassette bar gene transferred particle glass transformants selected using finally southern blotting analysis indicated bar gene successfully integrated nuclear genome using transgenic techniques transformation efficiency glass method slightly higher particle first report stable transformation improve fundamental research application
studies south african struggle focused political strategic concerns level formal organisations leadership yet anti struggle also impacted personal relationships social life put lives service article draws correspondence members african national congress based organisations chief representative region concerning recognition guidance love marriage family related matters period late early analyses demands struggle difficult context shaped love family relationships conceptions ways individual personal lives engaging political struggle part collective movement disciplinary parental role process developed manage relations also examined correspondence article argues governance personal life integral part nation building state making fulfilling affective functions
seasonal affective disorder primary care setting mood disorder subtype characterized episodic major depression typically develops winter daylight hours short patients sad experience increased morbidity decreased quality life article focuses recognition management condition light therapy preferred treatment sad safe easy light therapy combined pharmacologic therapy cognitive behavioral therapy cbt also positive therapeutic effect combined light therapy help prevent sad subsequent seasons
background bipolar disorder characterized presence psychotic symptoms comorbid substance abuse context structural metabolic dysfunctions reported psychosis addiction separately study aimed identifying neural substrates differentiating psychotic without substance abuse versus substance induced psychosis coupling first time magnetic resonance imaging mri positron emission tomography pet methods twenty seven type psychotic patients without substance abuse patients healthy controls enrolled study mri fdg pet scanning acquired results gray matter volume cerebral metabolism reductions temporal cortices observed patients compared healthy controls moreover distinct pattern limbic alterations found patients substance abuse specifically patients substance abuse showed volume reductions prefrontal cortex anterior cingulate insula thalamus whereas patients dorsolateral prefrontal cortex posterior cingulate common alterations cerebellum posterior cingulate found substance abuse finally unique pattern volumes reduction concomitant increased striatal metabolism observed patients conclusions findings contribute light identification common distinct neural markers associated bipolar psychosis substance abuse future longitudinal studies explore effect single substances abuse patients first episode psychosis elsevier masson sas rights reserved
objectives study examined whether individuals parkinsons disease increased vulnerability vascular related cognitive impairment relative controls underlying assumption behind hypothesis relates brain reserve vascular risk factors impair similar executive cognitive systems methods sample included patients older controls total participants completed neuropsychological measures executive functioning processing speed verbal delayed recall memory language auditory attention cardiovascular risk assessed cardiovascular risk index participants underwent brain imaging trained raters measured total regional deep subcortical results hierarchical regressions revealed severe cardiovascular risk related worse executive functioning processing speed delayed verbal recall parkinson patients controls severe cardiovascular risk related worse language functioning group controls contrast related cardiovascular risk executive functioning controls group conclusions overall results revealed cardiovascular risk factors independent risk factors cognitive impairment generally influence cardiovascular risk factors cognition similar patients controls
labview one various programming platforms widely utilized researchers form industry academia due simple use graphical programming environment extra ordinary easy interface hardware labview equipped various built perform different measurement control tasks one tasks solving optimization problem often encountered researchers variety fields viz control engineering civil design machine design digital signal processing economics etc however standard labview package equipped single global optimization algorithm differential evolution algorithm exists need efficient global optimization techniques paper deals concern effort made develop widely established practiced global meta heuristic algorithm search algorithm csa labview environment test csa implementation labview environment nine benchmark test functions used comparative study made algorithm found conducted studies csa efficient solving optimization problems better convergence rate repeatability
studied fields oncology stem cell biology tissue engineering study found new polymer material thermo controlled monolayer cell culture switching polymers groups polymers exhibited upper critical solution temperature type phase separation behavior cells monolayer culture converted addition polymers phase separation temperature time observations indicated cells began migrate aggregate form avoid contact phase separated polymer surface culture supposed seemingly suppressed interaction cell surface extracellular matrices increasing culture temperature began collapse monolayer cells due dissolution results indicated cell morphology repeatedly switched changing culture temperature presence polymers
every performance meet registered usa recorded online database times dating back first time statistical analysis machine learning methods systematically applied swim records study investigate performance features function age gender performance males females different ages studied correlations performances different ages estimated using pearson correlation regression analysis show performance trends males females different ages suggest critical ages peak training moreover assess twelve popular machine learning methods predict classify performance method exhibited different strengths weaknesses different cases indicating one method predict address problem propose new method combining multiple inference methods derive classifier simulation experiments demonstrate consistent method better overall prediction accuracy study reveals several new age dependent trends swimming provides accurate method classifying predicting swimming times
previously reported successful induction complete mice neonatal testis tissues cultured gel culture medium supplemented bovine serum albumin product method however examined fetal testis tissues report tested culture method fetal testes gfp transgenic mouse whose testicular germ cells express gfp phase using max containing medium fetal testis days back showed progression produced cells culture hand testes earlier show sign gfp expression regardless fetal age tissue masses enlarged culture period elongation thickening simple culture method useful experimental system investigate fetal testicular development germ cell biology
controversies surgical protocols total hip arthroplasty ankylosing spondylitis still exist aim study retrospectively analyze perioperative outcomes related performing patients data patients underwent retrospectively analyzed clinical imaging data collected preoperatively postoperatively follow period surgical efficacy using approach selected cases mean follow period years range years degrees degrees range degrees degrees degrees degrees range degrees degrees respectively mean visual analog scale vas score decreased range preoperatively range final follow mean hip score improved range range postoperative range motion flexion improved degrees degrees range degrees degrees preoperatively degrees degrees range degrees degrees final follow extension improved degrees degrees range degrees degrees degrees degrees range degrees degrees ossification documented signs stable fibrous bone detected respectively never injury occurred cases treated signs fractures dislocation prosthesis surgical patients severe hip involvement satisfactory
non alcoholic fatty liver disease common patients type diabetes approximately two thirds diagnosis disease currently validated treatment weight loss number studies animal models human trials evaluated effects like peptide receptor agonists liver fat content suggest treatment represent new alternative management review focus main studies regarding effects also mechanisms explain beneficial effects liver diseases analyzed elsevier masson sas rights reserved
background elevated gene related tumorigenesis deterioration different cancers including non small cell lung cancer nsclc however effect nsclc remains unclear study aimed investigate clinical significance effect biological function nsclc results significantly overexpressed nsclc tissues closely correlated deterioration nsclc based tissue microarray database meta analysis knock proliferation migration invasion nsclc cells inhibited angiogenic ability nsclc cells weakened furthermore expressed genes significantly related signaling pathway based bioinformatics approaches materials methods tissue microarray cancer genome atlas database meta analysis performed analyze relationship clinicopathological parameters nsclc furthermore western blot analysis scratch assay colony formation assay transwell migration invasion assay embryo membrane cam model conducted explore effect nsclc vitro vivo additionally bioinformatics analyses carried assess potential pathways networks expressed genes conclusions positively activated tumorigenesis deterioration nsclc hypothesize play important role nsclc via signaling pathway inhibiting expression expected become novel method therapeutic strategies nsclc
paper presents economic analysis hybrid system school potential renewable power system school evaluated optimization model used evaluate different possible configuration options supplying electrical load daily typical energy consumption profiles four seasons design based medium size school spring summer autumn weather conditions extreme winter decreases load demand seasons winter weather conditions used basis peak energy demand expected lighting heating loads dominate climate winter electrical load found maximum load software tool used determine optimum size specifications renewable power system solar radiation wind speed maximum values kwh fuel price assumed minimum feasible power system economically battery total net present cost cost energy kwh renewable fraction solar radiation wind speed fuel price assumed average values kwh optimal solution also battery kwh solar radiation wind speed presumed minimum values kwh fuel price assumed maximum feasible economical system still battery kwh excess electricity hybrid power system spring summer autumn utility general electrical network used applications enhance economical feasibility hybrid power systems schools authors published elsevier ltd
new advances computer hardware software users now widespread accessibility multicore devices inside personal computers making feasible fast indoor airflow simulations exciting preliminary results cross platform parallel computing framework using specific hardware reported however results largely based two hypotheses code devices generate results device running parallel multiple processors faster running sequential single processor study attempted evaluate two hypotheses systematically studying accuracy computing speed indoor airflow simulations fast fluid dynamics code selected indoor airflow simulation program compare cross platform ability evaluation performed using four graphics processing units gpus five central processing units cpus three manufacturers different degrees computing capability mounted two operating systems test subjects evaluated using four case studies consisting various indoor sequential code programmed computational fluid dynamics cfd program first used perform case studies generate numerical benchmarks comparison numerical simulation results experimental data showed cfd predict studied flows averaged relative errors respectively afterwards accuracy speedup code compared numerical benchmarks although code cpus generated identical numerical results results gpus slightly likely due varying interpretations institute electrical electronics engineers standard depending hardware code varied times cpus times gpus computing speed happened running two core cpu windows operating system using camp mac computer finally separate study relationship speedup global work size showed speedup achieved using gpu
background reactions rituximab occur frequently patients developing reaction initial exposure safety patients reaction clear standard guidelines lacking objective better understand clinical decision making surrounding rituximab reactions subsequent methods performed year retrospective review rituximab reactions large academic outpatient infusion center patients demographic characteristics clinical symptoms management reactions reviewed reaction severity classified using standard criteria results june january patients mean age years men least rituximab reaction identified reactions occurred first exposure rituximab reactions grade fifty one patients rituximab day initial reaction patients grade reaction tolerated conversely patients grade reaction reaction outcome day initial grade reaction varied patients tolerated day challenge patients reaction grade severity conclusions consistent previous data observations suggest patients experience grade reactions rituximab safely day grade reaction prompt referral allergy specialist risk assessment additional rituximab administration research needed understand optimal management patients grade reactions american academy allergy asthma immunology
current accurate stereo matching algorithms employ key techniques suitable parallel gpu architecture directly take techniques gpu applications trying tackle difficulty design two gpu based stereo matching algorithms one using local fixed aggregation window whose size configurable using adaptive aggregation window includes necessary pixels use takes principle optimization plain voting refinement post processing need complex data structures aim implement gpu platforms fast stereo matching algorithms produce results level quality local dense methods use window based cost aggregation gpu based implementation fixed window partially stereo matching application accelerations times obtained large size images gpu based implementation adaptive window color stereo matching application experiment results show handle four pairs standard images database within roughly elsevier rights reserved
objective assess year safety rheumatoid arthritis psoriatic arthritis psa ankylosing spondylitis methods subcutaneous every weeks evaluated phase trials patients active psa safety data year pooled across trials evaluating methotrexate naive experienced antitumor necrosis factor tnf experienced patients psa trial trial data summarized derived placebo controlled weeks uncontrolled study periods adverse events special interest serious infections opportunistic infections deaths malignancies demyelination tuberculosis incidence per patient years determined results across trials patients received placebo received safety extended weeks placebo respectively respective placebo incidence year lymphoma demyelination death lymphoma demyelination incidence appeared higher among patients receiving conclusion safety year remained consistent previously reported year findings tnf antagonists numerically higher incidences lymphoma demyelination observed versus forward reveal raise
offshore wind turbines take advantage vast energy resource open waters face structural integrity challenges specific operating environment require cost effective load solutions paper introduces computational methodology model based two three dimensional design load systems offshore wind turbines hydro model formulated convenient state space representation coupling multi body composite beam description main structural elements unsteady vortex lattice description hydrodynamics require empirical corrections focuses control oriented approach modelling numerical results show edge actuated robust controller reduction dynamic loading due atmospheric turbulence achieved sectional model close reduction blade loads obtained complete three dimensional floating turbine
paper proposes new model method algorithms processing subject domain considers set objects domain set connections objects set mass problems solved domain object represented essential attributes allows describe solve mass problems control state domain goal paper develop method algorithms allow find essential attributes domains described relational databases production systems production system build dependency graph attributes calculate value indicates many attributes found using particular vertex high ranked considered essential method based considering essential frequently accessed attributes relational database essential attributes objects domain allows define essential attributes domain
optical method developed estimate water transparency underwater visibility terms depth follows remote sensing contrast theory major factors governing variation namely turbidity length attenuation coefficient beam attenuation coefficient diffuse attenuation coefficient obtained based band techniques found band ratio remote sensing reflectance expressed contains essential information water column optical properties thereby positively correlates turbidity beam attenuation coefficient obtained linear relationship turbidity derive vertical diffuse attenuation coefficient estimated function reflectance ratio provides bio optical link chlorophyll concentration present algorithm applied modis images results evaluated comparisons remotely estimated situ coastal waters point regions southeast coast india results showed pattern increasing shallow waters deep clear waters statistical evaluation results showed percent mean relative error modis derived situ values within close agreement achieved spatial modis derived situ month january august promises model capability yield accurate estimates coastal waters spatial included provide best data visualization measured modeled situ satellite derived products modeled satellite derived values compared measurement data yielded rmse modeled rmse satellite derived products
contraception essential tool reproductive management species association reproductive management center data contraception use provides recommendations although given oral contraceptive pills least years published reports basic information pill administered formulations used effects physiology behavior report survey results characterizing use pan housed north american information accumulated contraception database females treated failures nine commonly administered formulation contained estradiol females combined oral contraceptives given continuous active pill regimen hormone free interval least days allowed pill mixing food common females seldom experienced breakthrough bleeding conditions sometimes observed females continuous females exhibited degree swelling mean score commonly reported behavioral changes included less sexual behavior dominant females becoming negative effect mood change weight noted taken together results indicate effective reversible contraceptive option used limit reproduction wiley periodicals inc
background little known patterns medication use lifestyle counseling patients peripheral artery disease pad united states objectives authors sought evaluate trends medical therapy lifestyle counseling pad patients united states methods data outpatient visits among patients pad obtained national ambulatory medical care survey national hospital ambulatory medical care survey nationally representative assessment office based hospital outpatient department practice trends proportion visits medication use antiplatelet therapy angiotensin converting enzyme inhibitors angiotensin receptor blockers lifestyle counseling exercise diet counseling smoking cessation evaluated results year period average annual number ambulatory visits united states pad across visits mean age years female non hispanic white comorbid coronary artery disease cad present visits medication use cardiovascular prevention symptoms low antiplatelet therapy standard error visits exercise diet counseling used visits among current smokers pad smoking cessation counseling medication used visits significant change medication use lifestyle counseling time compared visits patients pad alone comorbid pad cad likely prescribed antiplatelet therapy odds ratio confidence interval smoking cessation counseling conclusions use guideline recommended therapies patients pad much lower expected highlights opportunity improve quality care high risk patients american college cardiology foundation
extreme sexual behaviors controversial construct recently considered candidate disorder dsm rejected also rejected inclusion section iii conditions study nonetheless found important predictor among sex offenders continues discussed widely literature present study investigated developmental roots construct sample adult male sexual offenders administered multidimensional assessment sex aggression physical psychological sexual abuse experiences estimated using several scales early development psychological abuse childhood adolescence especially father found prominent predictor sub thoughts behaviors accumulation abuse types however also associated monotonic increase latent trait hyper sexuality consequences results construct discussed
large model repositories common objects now ubiquitous increasingly used computer graphics computer vision analysis synthesis tasks however images objects real world richness appearance repositories capture largely existing models work develop automated pipeline capable texture information images real objects models similar objects challenging problem objects texture seen distorted many factors including pose geometry illumination geometric distortions order transfer pure underlying texture new object model instead using problematic dense problem reconstruction set base materials illumination model object image exploiting geometry similar model reconstruct certain reliable texture regions correct illumination full texture map recovered applied model method allows large scale unsupervised production models directly image data providing high quality virtual objects scene design photo editing applications wealth data training machine learning algorithms various inference tasks graphics vision
background despite positive evaluation various caregiver interventions past decades intervention protocols translated delivery service contexts purpose study train care long term care problem solving evaluate approach additional component care counselling germany methods pragmatic cluster randomized controlled trial sites care randomly assigned provide either routine counselling plus additional problem solving caregivers routine counselling alone training comprises initial day training follow day months supervision contacts months phone agreed minimum counselling intensity one initial face face contact including caregiver assessment least one telephone follow contact caregivers positively screened significant strain role followed months baseline assessment main outcome caregivers depressive symptoms discussion unclear expected low amount additional counselling time sufficient yield additional effects caregiver depression also unclear additional problem solving component yields routine counselling based information case management different potential individual organisational barriers consistent intervention delivery like participation time extra work internal motivation participate
aim aim study test psychometric properties health indicator scale adolescent population methods investigation performed among swedish students aged years girls assessed acceptability psychometric properties evaluated according classical test theory regarding targeting reliability external construct validity results adolescents found easy complete questionnaire completed average minutes exploratory factor analysis based correlations identified one factor supporting instruments floor effects reliability estimates yielded cronbachs alpha value test retest reliability week interval coefficients total score item scores spearman correlations variables based priori expectations self rated general health depressive symptoms anxiety sleep problems conclusions observations support acceptability psychometric properties brief assessment tool health adolescents studies using modern test theory needed better understand measurement properties including functioning response categories adolescents adults
background generalized defined increased range joint motion compared general population predisposing factor sports injuries especially lower extremities nevertheless little evidence relationship generalized sports injuries upper extremities objectives evaluate relationship generalized acute chronic shoulder injuries athletes patients methods study comprised volunteer athletes history least six months sports activities shoulder injury three years prior participation study athletes divided two groups without generalized acute chronic shoulder injuries shoulder pain shoulder instability functional status assessed via measure determined compared two groups value less considered significant results group consisted participants group without consisted participants athletes group shoulder pain chronic shoulder injuries shoulder instability less functionality group fracture considered acute injury groups athletes generalized acute shoulder injuries conclusions generalized important predisposing factor acute chronic shoulder injuries athletes programs rehabilitation shoulder programs sports athletes high risk strongly recommended
tools estimate survival developed general cancer populations older patients breast cancer accurate overall survival estimates facilitate discussions adjuvant therapies secondary analyses performed data two parallel breast cancer studies alliance alliance included patients age years older complete baseline quality life data estimated versus observed cause two year mortality rates compared score calculated based age sex daily function derived scores range higher scores indicating worse prognosis based mortality community dwelling categorized three groups observed mortality rates estimated using kaplan meier methods patient mean age years range stage disease patients classified good prognosis poor prognosis two year observed mortality rates significantly lower estimates patients scoring trend seen scores tool modestly mortality rate older breast cancer patients enrolled two cooperative group studies tool estimates non cancer mortality risk based readily available clinical information inform adjuvant therapy decisions validated non clinical trial populations
elevation bradykinin level attacks hereditary angioedema due inhibitor deficiency inh hae known previously demonstrated level also increases inh hae attacks although potent peptides aspect inh hae yet investigated hence studied levels peptides controls inh hae patients evaluated changes inh hae attacks levels arginine measured plasma inh hae patients inter attack periods control subjects using technologies inh hae patients levels peptides compared blood samples obtained attacks inter attack periods levels similar inter attack samples inh hae patients samples controls although cardiovascular risk effect levels peptides groups levels three peptides increased inh hae attacks moreover levels changes attacks significantly correlated study demonstrated vascular regulation peptides affected inh hae attacks results suggest cooperation several peptides necessary actions excess attacks reveal novel pathophysiological aspect inh hae
study aims explore role microrna mir regulation cell proliferation human epidermal keratinocytes psoriasis twenty eight patients diagnosed psoriasis vulgaris selected case group non skin tissues collected control group consisted patients underwent plastic surgery healthy skin tissues collected real time quantitative fluorescence polymerase chain reaction qpcr situ hybridization immunohistochemistry used detect expressions mir healthy skin psoriatic skin non skin respectively untranslated region combined mir verified dual luciferase reporter assay western blotting applied corresponding detection expression cell expression mir psoriatic skin less healthy skin psoriatic non skin psoriatic non skin positive cell rates number positive cells per square higher healthy skin dual luciferase reporter assay verified mir targets transfected mir mimics decreased expression along decrease indexes labelling indexes however transfected mir inhibitors showed increased expression indexes labelling indexes transfected mir inhibitors decreased indexes labelling indexes results indicate mir negatively regulate proliferation psoriasis targeting
objective article present framework couples cloud high performance computing parallel map projection vector based big spatial data past years witnessed tremendous growth variety high volume spatial data big spatial data map projection often needed example apply big spatial data large scale spatial analysis modeling approaches require common coordinate system however due size data algorithmic complexity map projections transformation big spatial data alternative projections represents pressing computational challenge recent advancement cloud computing high performance computing offers potential means addressing computational challenge parallel map projection framework presented study based layered architecture couples capabilities cloud computing high performance computing accelerated graphics processing units use large lidar data example vector based big spatial data investigate utility parallel map projection framework experimental results reveal framework provides considerable acceleration vector based big spatial data coupling high performance cloud computing complement suggested solution efficient processing analysis big spatial data elsevier ltd rights reserved
global functional brain network graph suitable characterizing brain states local analysis connectivity brain regions therefore graph theoretic approaches natural methods use studying brain however conventional graph theoretical analyses limited due lack formal statistical methods estimation inference example concept correlation two vectors graphs yet defined thus introduction notion correlation graphs becomes necessary better understand brain sub networks interact develop framework infer correlation graphs one assume generated models parameters models random variables possible define two graphs independent random variables representing parameters independent real world however model rarely known consequently parameters estimated analyzing graph spectrum shown spectral radius highly associated parameters graph model based framework correlation inference graphs constructed approach illustrated functional magnetic resonance imaging data subjects comprising controls individuals diagnosed autism spectrum disorder asd results show correlations default mode control default mode default mode visual sub networks higher individuals asd controls elsevier rights reserved
context hormone like peptide also affect hormone neuropeptide truncated consequence affinity changes receptor mediates function receptors little known whether inhibitors treatment type diabetic patients influence pathways aims investigate vitro effects inhibition isolated abdominal subcutaneous adipocytes fat metabolism assessment receptor expression adipose tissue methods vivo human taken women undergoing elective surgery body mass index mean age years isolated adipocytes treated human recombinant without inhibitor glycerol release tissue distribution messenger rna mrna measured compared lean obese subjects results conclusion reduced glycerol release effect enhanced incubation inhibitor control mean mol mmol inhibitor mol expressed relative mrna expression lower taken obese signal units lean subjects predominantly expressed fat present fat higher obese subjects particularly obese lean appears regulated derived inhibitors augment effect studies required show whether explains lack weight loss patients treated inhibitors
background relative performance semi quantitative amyloid positron emission tomography pet cerebrospinal fluid csf markers diagnosing alzheimers disease predicting cognitive evolution patients mild cognitive impairment mci still debated methods subjects alzheimers disease neuroimaging initiative complete baseline cognitive assessment mini mental state examination clinical dementia rating alzheimers disease assessment scale cognitive subscale scores csf collection amyloid beta beta tau phosphorylated tau scans included cross sectional cohort among patients mci substantial memory complaints constituted longitudinal cohort followed months pet amyloid deposition quantified using relative retention indices standardised uptake value ratio respect cerebellar composite reference regions diagnostic prognostic performance based pet csf evaluated using roc analysis multivariate linear regression survival analysis cox proportional hazards model results cross sectional study included participants revealed composite values better classifiers auc diagnostic accuracy csf markers auc accuracy beta tau respectively strong independent determinant cognition multivariate regression whereas beta tau also determinant lesser degree among patients longitudinal study converted within months optimal thresholds differentiate converters quite similar cross sectional study composite best classifier auc sensitivity specificity multivariate regression baseline cognition main predictor subsequent cognitive decline composite moderate independent predictors final status progression rate whereas baseline csf markers marginal influence adjusted hrs conversion pet profile beta profile tau profile conclusions semi quantitative amyloid pet appears powerful csf markers grading mci prognosis terms cognitive decline conversion
objective investigate whether improves social cognitive impairments executive dysfunction people schizophrenia methods fifty six patients met diagnostic statistical manual mental disorders fifth edition diagnostic criteria schizophrenia allocated treatment group typical antipsychotic treatment group twenty eight healthy volunteers recruited normal control group positive negative syndrome scale interpersonal perception task card sorting test rated baseline weeks treatment typical antipsychotics results typical antipsychotics decreased positive negative syndrome scale scores total psychopathology positive negative symptoms baseline total scores five factor scores number categories completed percentage conceptual level responses significantly lower whereas total response errors errors failure maintain set significantly higher patient groups repeated measures analysis variance revealed significant main effect time period baseline weeks weeks scores performances significant interactions time period group multivariate analysis variance showed significant differences scores weeks significant differences two groups weeks significant differences also found performances weeks conclusion individuals schizophrenia impairments social cognitive executive function improved
gene encodes transcription factor plays critical role heart development humans heterozygous mutations result congenital heart defects however molecular mechanisms mutations cause disease remain unknown mutation reported associated atrial defect asd block patients one family mutation located within dna binding domain nuclear localization sequence protein pathogenesis humans point mutation understood examine functional deficit associated mutation vivo generated characterized knock mouse human mutation systematic structural functional examination embryonic newborn adult mice revealed homozygous embryos developmentally around delayed heart morphogenesis downregulation target genes histological examination newborn showed displayed asd least adult displaying defect moreover heterozygous newborn mice downregulation ion channel genes adult mice prolonged interval indicative degree block collectively present study demonstrates mice point mutation allele humans point mutation elsevier ltd rights reserved
paper presents set experiments formal modelling verification avoidance algorithm automatic train supervision system algorithm modelled verified using four formal environment namely spin experience gained multiple modelling verification experiments described show algorithm design structured set concurrent activities shared memory replicated formal frameworks taken consideration relative effort addition highlight specific various tools languages emerged along experience
accumulating evidence suggests ribosomal proteins functions various physiological pathological processes including cancer analyzed expression ribosomal protein colorectal carcinoma para carcinoma samples bioinformatics analyses data extracted cancer genome atlas colorectal cancer cell lines vitro qpcr highly expressed carcinoma samples colorectal cancer cells also colorectal cancer crc cell line mediated small interfering rnas studied impact knockdown expression cell growth rna interference rnai mediated inhibition expression significantly suppressed proliferation increased apoptosis cells tended arrest phase data suggest plays critical role proliferation cell cycle distribution apoptosis human malignant colorectal cells therefore potential target therapeutic strategies
human dog interaction relies large extent nonverbal communication therefore plausible human sensitivity nonverbal signals affects interactions human dog experience dogs also likely influence human dog interactions suggested influences human social skills present study investigated possible links human nonverbal sensitivity experience dogs quality human dog interactions two studies reported study veterinary students took psychometric test assessing human nonverbal sensitivity answered questionnaire experience dogs data obtained used investigate relationship experience dogs sensitivity human nonverbal communication results indicate experience dogs improves human nonverbal sensitivity study students high students low levels human nonverbal sensitivity selected students interacted unknown dog situation human dog interactions found combined score dog behaviors relating insecurity associated students level nonverbal sensitivity experience dogs dog showed insecure behavior interacting students low level nonverbal sensitivity experience dogs interacting students high level nonverbal sensitivity irrespective experience dogs
much research databases focused modeling time related data either attribute attribute approach data attributes approach objects history several although numerous studies data models work contrasting two common approaches terms system performance ease use paper compared interval based attribute data models running sample queries measure processing time evaluated usability using data tests indicate attribute model one level nested approach required less time used less disk space therefore appropriate modeling data
power system reliability faces serious challenges supply shortage occurs unexpected generation transmission line especially extreme weather conditions alternative conventional approaches aids generation side operators now leverage demand side resources variety electricity market mechanisms balance active power enhance system reliability benefits demand response long recognized many works empirical cases systematic analyses however never addressed assess values market based supporting system reliability paper case study performance north american polar vortex provided highlight significant contributions improving system reliability maintaining grid stability programs unique merits technical economic environmental aspects exhibited extreme event conventional system reliability improving approaches also demonstrated accordingly furthermore reveal difference programs driven various existing market mechanisms describing fundamental functions values various programs also highlighted last challenges opportunities facing china design implementation programs transform scheme open electricity market power industry recent years also discussed elsevier ltd rights reserved
leaf area important plant canopy structure parameter important ecological significance light detection ranging technology lidar application terrestrial laser scanner appealing method accurately estimating leaf area however actual utility scanner depends largely efficacy point cloud data analysis paper present novel method quantifying total leaf area within tree canopy firstly shape normal vector distribution structure tensor features combined semi supervised support vector machine svm method separate various tree organs branches leaves addition moving least squares method adopted remove points caused leaves wind scanning process secondly target tree scanned using two patterns one scan three scans around canopy reduce occlusion effect specific layer strategies according acquisition ranges designed separate canopy several layers randomly chosen analytic dataset ads ads innovative algorithm assembly threshold designed transform discrete scanning points leaf surfaces estimate fractions surface covered laser pulses novel ratio point number leaf area layer defined combined total number scanned points retrieve total area leaves canopy quantified total leaf area tree validated using measurements plant canopy portable area meter results showed individual tree leaf area accurately reproduced using method three registered scans relative deviation less nevertheless estimations one scan resulted deviation retrieved individual tree leaf area due occlusion effect indeed study provides novel connection leaf area estimates scanning sensor configuration supplies interesting method estimating leaf area based
probabilistic ecological risk assessment conducted transformation products beta blockers selective serotonin inhibitors assess potential threats aquatic organisms effluent dominated surface waters end pharmacokinetic literature university database pathway prediction system aerobic microbial degradation software literature pertaining beta blockers used determine likely formed via human metabolism aerobic respectively monitoring data north american european surface waters receiving human wastewater inputs basis exposure parent compounds available cases monitoring data exist assumed conservative parent production ratio parent converted environmental protection agency software used estimate acute chronic toxicities aquatic organisms hazard calculated using percentile exposure distributions ranged significantly less based results interest expected pose little environmental risk surface waters receiving wastewater inputs overall recommend developing analytical methods isolate quantify human metabolites environmentally relevant concentrations confirm predictions recommend identifying major species classes pharmaceuticals elicit toxic effects via specific modes action via serotonin receptors conducting aquatic toxicity tests confirm findings knowledge first quantitative probabilistic assessment predicted probable pharmaceuticals approach provides framework future studies compound classes data become available
explored acid alpha acid efficiently converted acid acid dha adolescent girls aged years consuming low fat diet low iron zinc status predicts conversion total fat intakes energy respectively three areas iron zinc intake varied day day significant negative association plasma found plasma significant positive association serum plasma dha associated negatively plasma showed population low intakes proportions phospholipid determines relative proportions dha low iron status probably attenuates conversion
purpose study investigate whether use computer graphics software affect elementary school childrens cognition purpose study carried childrens task observations retrospective interviews focus group conducted view points interpreting influences drawing graphics software childrens cognitive development main findings study children accuracy intuitive using mouse caused children difficulties drawing tested children choose one color corresponding showing children single color judgment children color learning model meet needs color cognitive development stage color replaced color using single object corresponding mobile drawing tools able encourage children contact observation real objects
achieving false belief understanding important cognitive allows children understand thoughts reality differ researchers found low income children score significantly lower middle income children false belief understanding examined difference exists hypothesized childrens language parent discipline mediate income false belief relation participants year olds false belief understanding significantly correlated family income childrens vocabulary parents self reported discussion childrens behavior discussion emotions power family income significant indirect effect false belief understanding childrens vocabulary parent discipline examined independently childrens vocabulary using parallel multiple mediation study contributes knowledge individual differences false belief understanding elsevier inc rights reserved
hepatocellular carcinoma major form primary liver cancer second sixth leading cause cancer related death men women respectively extensive research indicates wnt beta catenin signaling pathway plays pivotal role growth development differentiation hepatocellular carcinoma one major signaling pathways dysregulated hepatocellular carcinoma cyclin oncogene one major regulators wnt signaling pathway overexpression detected various types cancers including hepatocellular carcinoma using several validated bioinformatic databases predicted micrornas capable targeting untranslated region cyclin messenger rna according results mir selected highest ranking microrna targeting cyclin messenger rna luciferase assay recruited confirm bioinformatic prediction results cyclin expression first assessed quantitative real time polymerase chain reaction cell line cells containing mir expression mir cyclin evaluated results luciferase assay demonstrated targeting untranslated region cyclin messenger rna mir furthermore fold decline cyclin expression observed induction mir cells results highlighted considerable effect mirna induction regulation cyclin gene results suggest mir used novel candidate therapeutic purposes biomarker hepatocellular carcinoma diagnosis
many difficult problems applied mathematics scientific disciplines solved without powerful computational systems symbolic computation computer graphics paper construct two new families fourth order iterative methods finding multiple real complex zero given function developing methods recurrent formula generating iterative methods higher order solving nonlinear equations applied implemented symbolic computation several programs computer algebra system symbolic computation tool solving considered complex problem since provides handling manipulating complex mathematical expressions mathematical objects properties proposed rapidly convergent methods illustrated several numerical examples examine convergence behavior presented methods also give dynamic study methods using basins attraction methodology besides visualization iterative processes important features iterations including running cpu time average number iterations function starting points program basins attraction included elsevier inc rights reserved
paper explores important characteristics system linear equations containing parameters system equations arises many branches engineering including electrical circuits hydraulic networks structures solution set linear equations obtained applying rule many practically important cases parameters appear rank one dependency resulting solutions rational form monotonic parameter monotonic characteristic practical importance analysis design linear systems parameters interval uncertainties particular values system variables occur vertices parameter boxes
protein phosphorylation one major pathways used eukaryotic cells propagate signals final effectors regulating multiple aspects living cell metabolism growth differentiation adhesion motility genome stability death context tyrosine kinases play central role signal transduction overexpression activity implicated tumor onset malignancy progression date eight inhibitors approved fda treatment specific tumors spite efficacy resistance common feature prolonged administration selective pressure drugs fact induces clonal expansion subsets cancer cells harboring mutations leading decreased inhibition potency alternatively resistance inhibitors acquired activation others often unrelated reason stringent target selectivity inhibitors always considered desirable feature order limit toxicity molecules targeting different recently shown promising anti cancer agents understanding molecular mechanisms confer resistance inhibitors combination enzymatic structural cellular studies essential development second generation inhibitors active also towards drug resistant tumors
fast technique full wave optimization transmission reflection properties general linear time invariant high frequency components proposed method based poles rational function representing scattering parameters device designed generalization technique developed design optimization microwave filters performance proposed technique demonstrated two examples patch antenna fast convergence observed examples regardless quality starting point
altered microrna mirna expression found promote carcinogenesis little known role mirnas esophageal cancer study selected mirnas analyzed expression esophageal cancer cell lines tissue specimens using northern blotting situ hybridization respectively found let mir mir expressed cell lines mir mir expressed cell lines mir mir mir mir mir expressed cell lines others addition transient transfection mir inhibited met cyclin expression esophageal cancer cell proliferation whereas mir suppressed beta expression increased tumor cell proliferation furthermore found mir expression associated tumor cell lymph node metastasis mir associated lymph node metastasis mir associated higher pathologic disease stages patients esophageal adenocarcinoma kaplan meier analysis showed mir expression mir expression associated shorter overall disease free survival esophageal cancer patients addition mir mir mir expression associated shorter overall disease free survival patients esophageal adenocarcinoma however mir mir mir expression associated overall disease free survival squamous cell carcinoma patients data indicate evaluation mir mir prognostic biomarkers warranted patients esophageal adenocarcinoma addition role mir esophageal cancer also warrants study
direction social policy new fifth national government demonstrated white paper vulnerable children document advocates increased monitoring welfare populations child protection policy technical administrative system managing risky families white papers release came soon report deaths twins treated media case child abuse exemplified use welfare reporting cases child abuse drawing analysis governing article explores media policy discourses reinforce normative patterns offering compelling pathways anxiety route citizens anxiety child abuse support modes
widely used model organism studying biology created specific literature database annotated users improve relevance accuracy search queries represents current knowledge specific organism biological process foundation genome scale computation models assembled literature searches topic two different existing databases web knowledge pubmed resulting independent articles manually relevance biochemical physiological molecular biology studies literature described use feed source studies excluded process resulted final list entries received additional classification form notes keywords present format easily searched customized according interests individual researchers tool also easily adapted species specific research topics elsevier rights reserved
introduction glial neuronal tumors display mutation represents diagnostic entities targeted therapies protein shown promising results aim study assess utility immunohistochemistry clone daily practice series glial compared molecular biology techniques methods performed cases used sanger sequencing allele specific quantitative pcr pcr detect mutation sufficient amount available results immunostaining detected cases cases cases performed sanger sequencing pcr cases pcr cases sanger sequencing two cases initial tumors sanger sequencing identified mutation tumors seven tested cases pcr showed mutation tumors tested cases six cases one results discordant five cases wild type techniques another percentage mutated ganglion cells low sanger sequencing failed detect mutation detected pcr conclusions tumors mutated cells anti appears sensitive sanger sequencing latter although considered gold standard used front detect mutation combination pcr appears efficient indication targeted therapies tumors
article describes practical lectures experience practical case study design implementation geographical information system brought several innovations study branch faculty science university article deals mainly introducing new practical example course database systems new theme explains design inner structure relational database valuable contribution lies way real database example practice explained students process education instruction started visit collection subsequently students worked computer laboratory trying find information plants various queries portal finally detailed model relational database explained teachers experience enriched students knowledge field conceptual database design
objective aim identify clinical demographic characteristics moderate response treatment among women diagnosis urgency predominant urinary incontinence methods multicenter double blinded week randomized controlled trial pharmacologic therapy urgency predominant urinary incontinence community dwelling women diagnosed item incontinence questionnaire previously performed participants randomized therapy daily placebo urinary incontinence assessed day voiding diaries secondary analysis defined reduction greater overall incontinence episode frequency compared baseline clinical demographic characteristics moderate treatment response assessed testing interaction characteristics intervention models responders adjusting clinical site results participants ages mean years white race mean urgency incontinence episodes per day baseline differences demographic clinical incontinence characteristics treatment placebo groups responders increase proportion responders increasing age parity among married women effect modification observed race ethnicity body mass index education employment status alcohol tobacco use conclusions ambulatory women urgency predominant urinary incontinence older age married higher parity significantly moderated potentiated effects pharmacologic therapy incontinence frequency study identifies certain populations increased responsiveness treatment antimuscarinic therapy used inform guide future therapy
construction industry crucial component hong kong economy safety efficiency workers two main concerns current approach training workers relies primarily practice experience conventional teacher settings site limitations however site training inefficient progress site site training provides little opportunity develop practical skills awareness needed hands experience effective way train workers safety awareness efficient working current novel information technologies paper describes new innovative prototype system proactive construction management system train installation workers highly productive fully aware hazards involved uses spread spectrum based real time location technology based data technology track construction resources people equipment materials etc provide real time feedback post event analysis training environment trial installation real site demonstrates benefits gained comparison equivalent training using conventional methods concluded although study based specific industrial conditions found hong kong construction projects attract wider interest use future elsevier rights reserved
oxidant antioxidant imbalance contribute pathophysiology autism spectrum disorder asd assayed urinary levels oxidative stress related biomarkers lysine total antioxidant capacity dna methylation biomarker hydroxy plasma levels superoxide dismutase sod major antioxidant enzyme examined relationship four biomarkers social responsiveness individuals asd healthy controls sex asd group control group age distributions asd group years control group years significantly different groups social responsiveness assessed using social responsiveness scale used standardized regression coefficients measure effect size asd group exhibited significantly lower urinary levels significantly elevated urinary levels control group urinary levels plasma sod levels significantly different groups asd group showed significantly higher scores control group plasma sod levels correlated significantly urinary levels standardized regression coefficients revealed levels larger effect size levels urine study firstly reveals imbalance urinary levels favor urinary levels contribute impaired social responsiveness individuals asd plasma sod levels also affect urinary levels
study analysed dietary intake people living hiv aids rural communities state nigeria simple random sampling technique used sample members two rural support groups high prevalence hiv state using interview schedule data analysed using descriptive statistics pearson product moment correlation test mean involvement agriculture reduced hiv infection extent involvement agriculture significantly reduced pre post hiv infection diet diversity score low among majority mean diet severely inadequate however change level involvement agriculture significant correlation dietary intake study concluded diet state inadequate thus need extension collaborate health sector develop nutritional guideline rural communities
paper presents overview examples material design development using classical thermodynamics calculation phase diagrams modeling integrated computational materials engineering approaches although examples given lightweight aluminum magnesium alloys structural applications fundamental methodology modeling principles applicable materials engineering applications examples paper demonstrated effectiveness limitations classical thermodynamics solving specific problems solid state precipitation aluminum alloys computational thermodynamics modeling combined critical experimental validation used guide selection design new magnesium alloys elevated temperature applications future material design development based holistic approach however key challenges exist many aspects framework lack diffusion mobility databases many materials systems limitation current microstructural modeling capability integration tools simulation codes different length scales elsevier ltd rights reserved
adapting known paradigm studying memory deese roediger mcdermott drm paradigm deese roediger mcdermott two experiments reported explore memory clips participants presented five experiment five second clips experiment nine popular popular identified pilot task sets clips following task participants asked write many recall also asked return week later complete second recall task participants recalled significant number related non presented experiments increased week later correct recall presented items decreased results discussed terms theory memory context providing novel method exploring organisation memory
direct structural identification quantitative assessment nmol level full pattern excreted metabolites made possible nmr measurements untreated urine samples stable isotope labelled drug analogues administered humans full potential new vivo nmr approach exemplified study group volunteers cysteine metabolism metabolic pathway cysteine man accepted far needs profoundly revised basis nmr results
common primary systemic vasculitis results inflammation medium large arteries innate adaptive immune mechanisms combine drive hyperplasia luminal stenosis ultimately occlusion pathogenesis incompletely understood activation resident dendritic cells via toll like receptors appears crucial event explore role pathogenesis including effects dendritic cell cell activation recruitment putative infectious triggers potential inhibition novel therapeutic strategy
background aims hepatitis virus hcv infection following liver transplant associated reduced graft patient survival transplant ribavirin treatment prevents recurrent hcv patients achieving viral suppression least weeks transplant evaluated whether bridging regimen pre post transplant safe effective prevent hcv recurrence patients less weeks hcv rna time transplant methods july given hcv without hepatocellular carcinoma hcc within italian program one hundred patients transplanted patients treated bridging therapy studied results liver transplant indication bridge subgroup hcc cirrhosis hcv genotype patients day median dosage day given median days transplant time patients still hcv rna positive median hcv rna one recipient virological breakthrough week post transplant one died treatment month post transplant sepsis achieved week sustained virological response acute cellular rejection occurred three recipients september recipients median follow months range conclusions patients suboptimal virological response bridging regimen helps avoiding post transplant graft
wireless mesh networks growing rapidly research community due numerous applications shared services feature kind networks connectivity opens network diverse kinds attacks attacks generate extra traffic possibly carries proposal framework includes approach security detecting mitigating attacks use non relational databases data correlation dissemination intrusion information among nodes reduce amount attacks short time data correlation done log data servers distributed intrusion detection prevention systems using information particular format intrusion prevention systems implemented kind solution case proposed finally case study presented using routing protocol force attacks comparing proposal open source blocking tool whole scenario generate similar attack patterns result comparison
background personality disorder associated elevated suicide risk level risk primary care settings unknown assessed whether among primary care patients linked greater elevation risk compared psychiatric diagnoses whether association modified gender age type comorbid alcohol misuse methods using data clinical practice research matched living controls gender age registered practice prevalence mental disorders alcohol misuse calculated cases controls separately conditional logistic regression models used estimate exposure odds ratios also fitted gender interaction terms formally tested significance estimated gender age specific effects results found fold increase suicide risk patients versus recorded psychiatric disorder four fold increase versus psychiatric illnesses combined borderline comorbid alcohol misuse associated fold increased risk respectively compared psychiatric disorders relative risks higher female male patients significant risks associated diagnosis identified across age ranges although greatest elevations younger age ranges years conclusions large elevation suicide risk among patients diagnosed comorbid alcohol misuse particular concern gps potentially key role play patients diagnosed particularly presence comorbid alcohol misuse help reduce suicide risk mean working specialist care agreed clinical pathways availability services comorbidities alcohol misuse opportunities gps develop specific clinical skills
flexible multi generation systems consist integrated flexibly operated facilities provide multiple links different sectors energy system present study treated design optimization conceptual integrated methanol producing existing combined heat power unit industrial energy utility supply danish city objective optimize economic performance minimize total emission required meet local district heating demand plus thermal utility demand design optimization considered selection location integration processes operation optimization respect hourly variations operating conditions year expected long term energy system development uncertainty analysis considering investment costs operating conditions applying previously developed design methodology scalable models considered processes developed system design optimized respect hourly operation period optimal design respect economic environmental performance involved maximum sized located next local industry rather connection existing unit local industry energy demands limited compared dimensions considered process integration found marginal compared economic environmental impact present case assessing impact uncertainties estimated performances net present value optimal design estimated vary within range response changes investment costs methanol price considering two different electricity price scenarios addition change interest rate found reduce lower bound reference operating conditions results suggest applied interest rate operating conditions particular methanol price much higher impact economic performance designs corresponding uncertainties investment costs addition study outcomes emphasize importance including systematic uncertainty analysis design optimization concepts elsevier ltd rights reserved
background biomedical approach menopause imply creation negative attitudes phenomenon time negatively affect womens life satisfaction behaviour family assumed physical activity defensive factor type activity reduce intensity menopause symptoms aim research determine relation menopause evaluation life satisfaction tactics influence employed marriage women differ involvement physical exercise participants procedure research conducted among women age physically active women women engage physical activity following research methods used menopause evaluation scale satisfaction life scale questionnaire influence close relations women men results positive evaluation menopause related involvement physical exercise stronger tendency use positive strategies exerting influence ones research also showed slight correlation life satisfaction involvement physical exercise negative evaluation menopause related avoiding physical activity conclusions physical activity frequently related positive attitude towards menopause use positive tactics exerting influence ones slightly positively conducive ones life satisfaction level
psychological adaptation following loss prove challenging types losses although social support beneficial research mixed terms identifying whether serves buffer distress following traumatic loss particular studies specific domains social support best predict positive outcomes sample african americans examined six types social support along perceived need satisfaction analyzed relation depression anxiety complicated posttraumatic stress disorder outcomes results multivariate analyses revealed level satisfaction physical assistance initial assessment best predicted lower levels depression anxiety posttraumatic stress disorder levels months later less need physical assistance predicted lower complicated follow clinical implications suggestions future research discussed
danish national birth cohort contains comprehensive information diet lifestyle constitutional major characteristics women pregnancy provides unique source studies health consequences gestational diabetes mellitus aim identify validate gestational diabetes mellitus cases cohort material methodswe extracted clinical information hospital records pregnancies included danish national birth cohort diagnosis diabetes pregnancy registered danish national patient register danish national birth cohort interview pregnancy validated diagnosis gestational diabetes mellitus randomly selected pregnancies entire danish national birth cohort individual hospital records expert panel evaluated gestational diabetes mellitus status based results oral glucose tolerance tests fasting blood glucose values diagnoses made local resultsthe audit categorized pregnancies gestational diabetes mellitus corresponding pregnancies pregnancy interview self reported diabetes pregnancy available randomly selected group combined information register interviews correctly identify cases entire danish national birth cohort population positive predictive value however conclusionsthe combined use data register interview provided high sensitivity gestational diabetes mellitus diagnosis low positive predictive value however suggests systematic validation hospital record review essential underestimate health consequences gestational diabetes mellitus future studies
measurements accelerometers originally deployed measure buildings structural dynamics serve new role locating individuals moving within building specifically paper proposes measurements generated vibrations novel source information localization complexity wave propagation building dispersion reflection limits utility existing algorithms designed locate example source sound room radio waves free space paper develops enhancements arrival time determination time difference arrival localization order address complexities posed wave propagation within buildings structure experiments actual measurements instrumented public building demonstrate potential locating sub meter accuracy furthermore paper explains forecast performance buildings different sensor configurations localization capability holds potential assist public safety agencies building incidence response facilitate occupancy based optimization heating cooling inform facility security elsevier ltd rights reserved
new images show variety display features relief surprising relatively small world features suggest global strain order early history extension consistent presence ancient global ocean now frozen authors published elsevier inc open access article license
study used qrt pcr examine variation expression muscle development four prenatal periods days post commercial three way large white cross local pig differ muscle mass variation expression genes various prenatal ages genes showed similar expression commercial pigs greater expression least one prenatal period pair wise comparisons prenatal periods breed showed genes higher expression least one prenatal period commercial pigs overall results identified gene primary candidate account differences muscle mass pig since activation gene lead greater fusion commercial breed compared pigs fusion explain different postnatal periods
tears common result considerable morbidity tears within tendon substance insertion head represent considerable clinical challenge hostile local environment healing tears often progress without intervention current surgical treatments inadequate although surgical implants instrumentation techniques improved healing rates improved high failure rate remains large massive tears use biologic contribute regenerative microenvironment great potential improving healing rates function surgery article presents review current emerging biologic approaches augment tendon muscle regeneration focusing scientific rationale preclinical clinical evidence efficacy areas future research current barriers advancement implementation
rice important food half worlds population demand expected increase increasing population developing countries mainly asia green revolution technologies transformed agricultural practices resulting considerable increase productivity rice later part century however rice agriculture currently faced multiple challenges declining yields lack water availability contamination natural resources due excessive use biodiversity losses greenhouse gas emissions losses due extreme climatic events strong need adapt agricultural practices order increase production rice manner economically viable environmentally sustainable review technologies already available contribute significantly towards achievement objective using modern high throughput technologies developing rice varieties possess traits climate resilience along higher yields effective management limited water resources high value rainwater harvesting groundwater recharge timing transplantation onset rain greatly contribute towards sustainability rice production maintained system reduce losses practices like laser fields dry alternate drying known considerably reduce irrigation water requirement system rice advocated increase rice yields water requirement input costs particularly resource poor conditions integrated nutrient management adjustment fertilizer dosage placement application increases nutrient use efficiency degradation natural resources runoff integrated pest management observation threshold values reduce environmental health costs undesired effects non target organisms development resistance residues food products along input costs obtain available technologies strong commitment extension policy institutions highly important use modern information technologies timely communication information weather forecast assist farmers decision making various farming activities
significant decreases hormonal levels menopause induce physiological functional discomfort skin representative changes menopause based called dry skin however evidence explain mechanism even though hydration stratum women menopause comparable enhanced hormone replacement therapy study objective evaluate structural functional changes ovariectomized mice model menopause hydration recovery permeability barrier function integrity cohesion dermatitis analysed mice underwent without replacement estradiol ovariectomized mice hydration reduced recovery permeability barrier function acute disruption impaired integrity weakened associated increased cohesion increased levels dermatitis replacement treatment restored changes immunohistochemistry revealed reduced levels expression differentiation markers epidermis ovariectomized mice compared control mice mice replacement treatment changes directly associated weakened integrity impaired permeability barrier function ovariectomized mice study results reveal called dry skin menopause caused lower hydration also complicated structural functional changes skin
across eight australia mandatory reporting thresholds reporting vary teachers one group professionals mandated report child maltreatment yet teachers still make report paper examines barriers teachers reporting child maltreatment also whether teachers consider necessary question child maltreatment decide report made thirty semi structured interviews primary school teachers thematically analysed revealed inadequate inconsistent mandatory reporting training need certainty initiating report ambiguous concept neglect barriers teachers identifying reporting child maltreatment analyses revealed teachers gather evidence confirm maltreatment questioning suspected child victim consequences practice discussed along recommendations help overcome barriers making formal report child maltreatment suspected
analytes yield nearly identical electron ionization mass spectra analytes yield nonspecific fragmentation patterns identified using fully integrated gas chromatography direct fourier transform infrared detection mass detection detector proved selective identifying analytes synthetic weight loss drugs limited relatively high detection limit parts per million ppm non targeted identification based single injection reduced parts per billion targeted identification ten injections along track detector less selective identifying analytes yielded non targeted targeted detection limits approximately respectively corresponded fold advantage compared detector overall results study demonstrate advantages detector compensate limitations allows wider range analytes concentrations examined using fully integrated instrument compared examined using independently approach reduce consumption laboratory resources time provides information sample important forensic analyses require data two orthogonal techniques make identification
grey water footprint refers volume water required polluted water reflects intensity water pollution caused water use human activities study aims address major shortcomings associated grey water footprint accounting literature discuss several ways towards improvement global maize production used illustration study specifically three issues appropriate water quality standards grey water footprint assessment grey water footprint multiple pollutants influence spatial resolution assessment level grey water stress biophysical crop model applied quantify nitrogen phosphorus losses water maize production global scale degree spatial resolution study shows grey water footprint calculation highly sensitive water standards applied results also suggest grey water footprint relating nitrogen phosphorus pollution caused maize production alone already exceeded local water availability many parts world grey water stress shows critical situation grid level watershed level maize cultivation former represents local concentration whereas latter gives average situation whole watershed study highlights need setting water quality standards consistent grey water footprint assessment taking consideration diverse aquatic ecosystems ambient water quality requirements across regions presence multiple pollutants water bodies elsevier ltd rights reserved
hilbert space singular integral operator non shift conjugation considered sigma bar continuous functions unit circle shift operator operator complex conjugation estimates dimension kernel operator obtained
objectives characterize psychotropic medication use traumatic brain injury tbi hospitalization among older adults secondary objective determine receipt indicated pharmacologic treatment anxiety post traumatic stress disorder ptsd differs following tbi design retrospective cohort setting united states participants medicare beneficiaries aged years hospitalized tbi continuous drug coverage months tbi measurements obtained monthly psychotropic medication use drug class specific drugs medicare part drug event files icd codes used define anxiety ptsd results average monthly prevalence psychotropic medication use among patients hospitalized tbi antidepressants constituted prevalence psychotropic medication use increased following tbi psychotropic medication use increased slightly antidepressant use decreased post tbi whereas use antidepressants increased antipsychotic use also increased post tbi beneficiaries newly diagnosed anxiety ptsd post tbi less likely receive indicated pharmacologic treatment conclusions older adults hospitalized tbi high prevalence psychotropic medication use yet less likely receive indicated pharmacological treatment newly diagnosed anxiety ptsd following tbi
clock gating effective way reduce dynamic power digital sequential circuits paper gate level activity correlation based clustering clock gating technique proposed digital filters technique exploits correlations determines group clock gating activity correlation matrix introduced describe correlations greedy clustering algorithm proposed find optimised clustering scheme experiments benchmarks show proposed technique reduce power consumption average top existing technique circuits large numbers proposed technique save power average
digital simple non destructive method estimating canopy biophysical parameters ecological applications validation remote sensing products determination optimum acquisition procedures documented literature far focused evaluating procedure used align camera paper standard recommendation necessity tested comparing hand procedure results show average difference two procedures effective plant area index gap fraction plot scale generally falls within variance users implementing hand technique expect large reductions data acquisition time allowing many samples collected without compromising overall quality data retrieved authors published elsevier
understanding structure function described immune system essential contemporary clear one size fits approach applied across multiple species inconsistencies nevertheless achieved immunology following application observations murine systems man pivotal advancement biology human medicine however additional species used address biologic safety assessment questions relative structure function immune system become clear differences across species gender age strain considered differences determined case case basis review article attempts collect discuss species differences thereby accurate placement new observations proper perspective
aim study investigate prevalence subclinical ankle involvement ultrasound patients rheumatoid arthritis study conducted patients healthy sex age matched controls patients history clinical evidence ankle involvement underwent examination ankle joint anterior tendon common posterior tendon common tendon tendon tendon assessed following abnormalities recorded rupture bmi esr crp also obtained total patients healthy controls assessed patients showed ankle abnormalities whereas control group found abnormalities subjects frequent abnormality patients followed patients positive found statistically significant correlation found findings age disease duration bmi esr crp present study provides evidence higher prevalence subclinical ankle involvement patients age gender matched healthy controls identified
new vision based system designed identification vibration vibration major obstacle machining causes bad surface increases damage costs research proposes use machine vision detection vibration frequencies high speed milling operations vision system utilizes digital image processing texture analysis determine frequencies marks surface developed system provides solution ease without expensive measuring equipment vision system verified compared detection methods identifying creating tests based dynamics machine tool
article focuses development awareness teaching professional russian formation competence represents one key elements professional teaching specialists competence comprises skills vital verbal nonverbal communication foreign language native speakers requiring perception management various socially culturally rooted language phenomena consideration cultural pertaining country language studied need develop competence poses new challenges teachers requiring develop new perception learning goals respective article didactic aspects learners adaptation foreign culture teaching effective communication achieve professional goals considering factor various didactic techniques analysed namely conceptual approach teaching foreign language formation discourse frames necessary professional everyday communication exercises texts containing information tailor made system exercises targeted eliminating possible communication failures cultural discrepancies purpose achieve level competence sufficient adequate correct implementation communication goals analysed situations everyday business communication published elsevier ltd
environmental enrichment strategy improve animal welfare providing brain plasticity changes cellular molecular behavioral levels order test long term effects enriched housing importance testosterone levels expression behavioral plasticity categories assessed adult swiss mice subdivided non groups maintained seven months three non enrichment consisted introducing tests spontaneous exploration barrier hierarchical organization group applied measurements body weight relative weight key organs done end experiment mice kept enriched either non showed spontaneous exploration raised standard non mice housed structured lower frequency attack resident test non standard mice indicating decrease first group independent housing conditions mice showed reduction defensive social contacts low frequency attack tests known importance testes ensure expression aggressive social contact behaviors therefore challenged enrichment condition behavioral repertoire home cage performance group test measurements significantly different groups kept enriched non enriched results suggest experience enriched environment increase aggressiveness routine home cage negatively influence physiological parameters independently testosterone level elsevier rights reserved
objective aims study investigate prevalence unadjusted adjusted odds month generalized anxiety disorder among adults migraine comparison without migraine debilitating pain limitations instrumental activities daily living mediators migraine association factors associated past year among adults migraine methods secondary data analysis nationally representative canadian community health survey mental health population based survey community response rate first subsample included without migraine second subsample restricted migraine based scale results fully past year comparison without migraine socio adjusted odds past year two half times higher among migraine without path analysis indicated debilitating pain limitations mediators relationship migraine sample restricted factors associated higher odds month included university degree low income without male conclusions generalized anxiety disorder robustly associated migraine targeted outreach interventions warranted
development performance characterization new differential pressure based flow meter human breath measurements presented article device called confined tube comprised pipe shaped expansion cavity located pipe center disk inside expansion cavity disk named tube different diameters smaller diameter cavity gap disk cavity allows flow human breath pass disk causes obstruction flow inside pipe cavity provides expansion flow around disk decreasing overall flow resistance characterize new sensor flow experimentally theoretically using software laminar turbulent models also validate sensor using inhalation tests reference method american institute chemical engineers
urban easily available settings engage daily physical activity type low cost physical activity walking bring multiple health benefits among park facilities park pathways significantly related physical activity present study examined links specific park pathway design characteristics senior walking within urban park observations interviews study conducted two neighborhood beijing china site observations utilized collect data senior walking behavior dependent variable pathway design characteristics independent variable calculated average number observed observations represent usage pathway segment interviews conducted explore pathway design characteristics preferred senior users anova analyses correlation analyses revealed prefer pathways soft even pavement plastic track light also attracted pathways long meters wide without connection activity zones addition results suggest pathway design characteristics along water body providing lateral visibility visual connection water without visual connection also encourage senior walking providing park pathways preferred designers create park environments supportive senior walking ultimately contribute improving senior health life quality elsevier gmbh rights reserved
current study aimed devise eco friendly safe cost effective strategies enhanced degradation low high density polyethylene using newly formulated microbial assess end products plastic degrading bacteria samples gathered highly plastic environments enriched standard protocols degradation ability zone clearance method percentage degradation monitored weight reduction process best isolates characterized standard microbiological molecular biology protocols best isolates employed form several combinations microbial degradation end products analyzed stability ribosomal dna rdna predicted bioinformatics approach study identified degradation strips strips respectively period days degrees formulated degradation efficiency found better comparison formulations end product analysis fourier transform infrared scanning electron microscopy energy dispersive spectroscopy nuclear magnetic resonance showed major structural changes formation bacterial biofilm plastic surfaces novel isolates designated bacillus rdna sequencing suggested good gene stability minimum gibbs free energy therefore study substantial information regarding utilization microbial rapid polyethylene removal
glycoprotein melanoma protein type transmembrane protein recently found play role cancer cell proliferation angiogenesis invasion due potential responsibility cancer aggressiveness main objective work investigate expression bladder cancer biological functions bladder cancer cells using immunohistochemistry western blot reverse transcription polymerase chain reaction analyzed expression glycoprotein melanoma protein bladder cancer tissues bladder cancer cell lines effects glycoprotein melanoma protein proliferation migration invasion tested glycoprotein melanoma protein bladder cancer cells small interfering rnas transwell assays results showed glycoprotein melanoma protein protein highly expressed bladder cancer tissues cell lines glycoprotein melanoma protein suppress proliferation migration invasion bladder cancer cells glycoprotein melanoma protein expression related poor differentiation recurrence immunohistochemistry analysis survival analysis also showed glycoprotein melanoma protein related patient prognosis conclusion glycoprotein melanoma protein protein highly expressed bladder cancer related poor prognosis bladder cancer patients glycoprotein melanoma protein promoted proliferation migration invasion bladder cancer cells
mammalian cell cultures preferred expression systems production requiring processing usually cell cultures cultivated medium supplemented serum supports cell proliferation viability productivity however due scientific regulatory concerns serum free conditions required recombinant protein production cell lines intended commercial recombinant protein production adapt serum protein free conditions early development labor time consuming process specific cell requirements related adaptation new microenvironment present study chinese ovary cell line producing recombinant human adapted growth production serum protein free conditions physiology growth parameters morphology cells biosynthesis structure closely monitored adaptation process avoid unwanted selection cell subpopulations results showed cells successfully adapted suspension growth production protein free conditions structure remained nearly unchanged addition production protein free suspension conditions rate seem significant optimal process performance contrast initial cell concentration evaluated evolutionary operation method international union biochemistry molecular biology inc
performance design methodology optical reconfigurable logic circuit using based optical micro ring resonator presented current paper proposed design reconfigurable logic circuit capable perform eight different logic operations performances logic circuits theoretically analyzed using domain modeling numerical simulation results confirming method explained present paper proposed circuit simple compact efficient minimum number low operating power high operating speed high factor different figure merits model calculated simulation results
background first directly acting antiviral made available chronic hepatitis india describe real life experience using ribavirin without interferon peg ifn predominant genotype patients methods total patients men mean age treated dual therapy triple therapy peg ifn included prospectively patients infection liver disease post organ transplantation excluded data analysed preference treatment regimen end treatment response sustained virological response side effects results genotype predominant genotype followed genotype genotype forty eight patients cirrhosis treatment experienced peg ifn total patients received dual therapy received triple therapy receive injections facility fear injection side effects financial constraints reasons triple therapy patients triple therapy group two patients dual therapy group attained achieved achieved sustained virological response groups anemia three patients two triple one dual therapy major side effects conclusions patients prefer oral treatment directly acting oral interferon based regimens achieve high response rate
whereas link working memory memory distortions demonstrated influence emotional false memories unclear two experiments verbal task false memory paradigm negative positive neutral events employed experiment investigated individual differences verbal found interaction valence predicted false recognition negative positive material protecting high individuals false remembering beneficial effect negative material disappeared low participants experiment lowered capacity half participants double task request led overall increase false memories furthermore consistent experiment increase negative false memories larger neutral positive ones concluded plays critical role determining false memory production specifically influencing processing negative material
interest important role ethical leaders play organizations expanded recent years several high profile corporate ethical increased responsibility placed upon corporate leaders result present study introduce new outcome ethical leadership group ethical voice tested two mediating mechanisms linking ethical leadership group ethical voice using two field studies one experimental study found support ethical leadership positively associated group ethical voice also found support hypothesized mediating mechanisms ethical culture group ethical voice efficacy linking ethical leadership group ethical indirect effect upper level ethical leadership group ethical voice via group ethical voice efficacy found group ethical voice positively influenced ethical performance significant sales groups marginally significant customer service groups contributions ethical leadership voice literature discussed along limitations current study directions future research
propose use negative spectroscopy technique improve detection limit rare analytes biological samples observe significant dependence negative force functionalized beads edges electrodes respect frequency electric field measured velocity conjugation functionalized beads automated software real time image processing monitors scattering beads significant difference velocity beads observed presence little molecules per functionalized technology applied detection quantification rare analytes useful diagnosis treatment diseases cancer myocardial infarction use beads functionalized antibodies target biomarkers society photo optical instrumentation engineers spie
industrial wireless networking protocol standard used process automation one mechanism based multi channel mac proposed solve industry wireless sensing questions network channel disturbance medium turning conflict mechanism mainly includes multi channel mac mechanism design proposal channel assignment algorithm design
pollen analyses web samples collected recently dominated tropical forest village district central india light relationship extant vegetation pollen rain study revealed dominance pollen trees whereas remains among tree taxa moderate low intermittent presence however rest forest constituents either represented despite presence attributed low pollen productivity owing poor pollen preservation pattern hand ground vegetation represented high frequency along however moderate lower values occur abundantly along stream banks marked sporadic retrieval ascribed prevailing condition around sampling study addition understanding pollen vegetation relationship also helpful study especially assessing various pollen grains area investigation causing bronchial asthma fever allergic rhinitis bronchial allergy respiratory disorders along contact dermatitis eczema food allergies health disorders
question becoming principal problem influences social safety acts aimed people normal functioning state trying achieve goal public utility facilities including transport system facilities one elements transport system infrastructure consisting roads bridge facilities last element encompasses example bridges taking account fact bridge facilities extremely sensitive attacks authors article decided focus study work presents original method damage risk assessment engineering facilities aspect potential attacks method based two selected multi criteria optimisation methods subject analyses four selected bridge facilities results conducted research analyses risk assessments selected bridges advantage presented solution possibility justify adopted hierarchy decision variants using proposed method one obtain specific numerical values used analyses conducted wider scale build database facilities prone attacks
integration nucleic acids detection assays microfluidic devices represents highly promising approach development convenient cheap efficient diagnostic tools clinical food safety environmental monitoring applications tools expected operate point care resource limited settings amplification target nucleic acid sequence represents key step development sensitive detection protocols integration microfluidic devices popular technology nucleic acids polymerase chain reaction pcr significantly limited thermal cycling needed obtain target sequence amplification review provides overview recent advances integration isothermal amplification methods microfluidic devices isothermal methods operate constant temperature emerged promising alternative pcr greatly simplify implementation amplification methods point care diagnostic devices devices used resource limited settings possibilities offered isothermal methods digital droplet amplification discussed
forming important natural pollutants genetic improvement important task introduction key dramatically improve remediation potential transfer key genes salt reported plays important role salt cycling elements nutrients pollutants protects erosion species salt supporting large food web turn supports significant segment economy including tourism impact cloud formation consequently global weather thus ecologically important species relevant life support systems inoculated pair agrobacterium strains carrying reductase genes respectively order introduce genes seven stable resistant lines recovered presence genes verified pcr southern blotting one transgenic lines contained sequences proving introduction two genes separate agrobacterium strains feasible frequent although overall frequency transformation low northern blotting showed differences relative expression two among individual transformants steady state rna levels appeared correlate phenotype line showed highest resistance whereas line resistant acetate wild type sensitive
eating disorders associated range abnormalities eating behavior individuals consume large amounts non caloric artificial suggesting abnormalities responding current study aimed quantify motivating effects artificial individuals without eating disorder two laboratory studies conducted preference estimated using number artificial packets added aid study motivation obtain assessed progressive ratio work task study ninety three participants anorexia nervosa restricting type binge type bulimia nervosa normal controls completed study significant difference preference found among participant groups work completed task ranged key board group significantly higher performed significantly work compared groups among participants preferred number equal packets significantly correlated total work increased amount work among individuals supports enhanced reward value sweet taste population suggests characteristic food avoidance accounted decreased reward value taste related stimuli study also supports novel application ratio task quantify motivating effect sweet taste among individuals eating disorder elsevier ltd rights reserved
visual animal emerging research discipline computer vision pattern recognition cognitive science promising research field encourages new development quantified algorithms methodologies representing detection visible features phenotypic species individuals recognition morphological animal biometric characteristics furthermore also study animal trajectory behaviours analysis species currently real world applications visual animal biometric systems gaining proliferation due variety applications use enhancement quantity quality collection extensive ecological data processing however advance visual animal require integration methodologies among scientific disciplines involved valuable efforts due enormous perspective approach formal abstraction build developed interfaces different organisational levels life study provides comprehensive survey visual animal biometric systems recognition approaches various species individual animal based morphological image pattern biometric characteristics comprehensive review paper encourages multidisciplinary researchers scientists different research communities design better platforms development efficient algorithms learning models solve massive data processing classification identification different species related problems
escherichia coli one coli among important food borne pathogens infecting children worldwide inhibition serotonin transporter regulates extracellular availability serotonin implicated previously associated diarrhea shown inhibit via activation protein tyrosine phosphatase albeit specific involved known current studies aimed identify activated role inhibition infection strain min increased activity domain containing similarly western blot studies showed increased tyrosine phosphorylation tyrosine indicative activation concomitantly infection decreased tyrosine levels associated increased interaction evidenced studies examine whether directly influences phosphorylation status function cdna plasmid constructs wild type constitutively active dominant negative overexpressed cells cells overexpressing constitutively active polypeptide showed complete loss tyrosine addition decrease function measured sensitive uptake increase association cells expressing constitutively active compared dominant negative data demonstrate intestinal target reveal novel mechanism common food borne pathogen uses cellular inhibit new noteworthy data presented current study reveal intestinal serotonin transporter target tyrosine phosphatase show novel mechanism common pathogen activates cellular inhibit function studies highlight host pathogen interactions therapeutic relevance management diarrhea associated enteric infections
moving others encourages prosocial behavior adults walk tap together later likely cooperative helpful rate previous studies demonstrated interpersonal encourages even month old infants however studies infants always experienced interpersonal context investigated whether synchronous movement context similar effects infant fourteen month olds faced infant either contrast previous studies instead listening music interpersonal movement phase infants nature sounds tested infant directed toward results showed synchronous still encouraged asynchronous despite absence music however helping delayed rates much higher previous studies music thus music necessary interpersonal influence infant presence music act mood regulator help keep infants happy allow fully experience effects synchronous movement
consider problem minimizing linear function affine section cone positive matrices additional constraint feasible matrix prescribed rank rank constraint active non convex optimization problem otherwise program find numerous applications especially systems control theory combinatorial optimization even general contexts polynomial optimization real algebra numerical algorithms exist solving problem interior point newton like algorithms paper propose approach based symbolic computation design exact algorithm solving rank constrained programs whose complexity essentially quadratic natural degree bounds associated given optimization problem problem size feasible matrix fixed complexity polynomial number variables algorithm works assumptions input data prove assumptions satisfied also implement maple discuss practical experiments
important factor prevention relapses schizophrenia empirical evidence presented organized conceptual four level framework address effectively prevent role classical insight plays neglect underlying motivational processes routine care four level framework address encompasses functional analysis adherence instrumental goal oriented behaviour addressing dysfunctional attitudes relation disorder treatment techniques strengthen therapeutic bond finally focusing obstacles ability adhere
purpose review classically features clinical presentation includes longitudinally extensive transverse optic however many phenomena recently described patients diagnosed including intractable vomiting painful less reported regarding relationship headache though headache established symptom comorbidity multiple sclerosis much less described thus far literature warrants careful evaluation many questions remain unanswered relationship headache including headache prevalence certain groups distribution primary symptomatic headache disorders seen frequently specific neuroimaging findings associated increased risk headache recent findings various types headache headache trigeminal autonomic like headache reported initial clinical presentation publications emphasized association etiologies headache trigeminal certain imaging findings lesions patients also associated headache summary link headache evident limited case reports clinical studies also imaging even potential common underlying biomarkers interleukin developing understanding association two diseases lead better management headache patients potentially lead earlier diagnosis headache serve initial presenting symptom even disease exacerbation
purpose examine association self reported stress levels ability women methods daily stress reported scale lowest highest among women completed daily diaries including data lifestyle behavioral factors menstrual characteristics contraceptive use intercourse cycles pregnancy discrete survival analysis used estimate associations self reported stress specific windows menstrual cycle cycles risk pregnancy adjusting potential confounders results one hundred thirty nine women became pregnant follicular phase reduction unit increase self reported stress estimated window odds ratio confidence interval attenuated trend window phase higher stress associated increased probability conception possibly due reverse causality conclusions higher stress window reduce probability conception however conception occurs changes hormonal milieu knowledge pregnancy result increased stress findings reinforce need encouraging stress management techniques mother elsevier inc rights reserved
log domain filters designed using signal now graph sfg synthesis approach appropriate set operators following procedure pole log domain filters exactly operation inductor capacitor prototype filter implemented case elliptic log domain filters transmission precisely realized due fact floating capacitors used order approximately perform required paper alternative sfg representation prototype system done way corresponding filter configuration implemented using log domain amplifiers third order log domain elliptic filter simulated order confirm validity proposed technique
objectives distinguish ethnic differences among restrictive anorexia nervosa using simple culture fair test body image figure methods several responses figure adolescent three distinct schools communities group severely restricting girls evaluations analyzed followed paired student tests comparisons responses groups respectively pearson served correlations fisher differences slopes results despite total ethnic segregation among prefer thinner ideal similarly however ethnic differences also emerge underestimate others view true ideal evaluations correlate unlike groups despite variability contrast girls show gross even comparison girls bmi discussion findings show figure evaluation simple robust instrument clinical ethnic responses clinicians consider body figure simple supportive diagnostic first line recognition risk adolescent girls
paper concerned centers problem cubic systems vector field based centers condition compute period constants obtain periodic constants basis center condition separately eleven conditions symbolic computation numerical analysis help computer algebra system moreover give sufficient necessary condition investigated cubic system pair centers terms result simultaneous centers including centers hardly seen published references result paper new
mutations cause amyotrophic lateral sclerosis als fatal disease characterized degeneration premature death motor neurons contribution mutant mediated damage within motor neurons evaluated using mice expressing conditional allele als causing mutant whose broad expression throughout central nervous system mimics endogenous mice develop age mutant dependent motor deficits degeneration death motor neurons cre mediated excision gene motor neurons shown delay onset motor symptoms appearance mediated aberrant nuclear morphology subsequent death motor neurons however reduction mutant selectively motor neurons prevent age dependent degeneration neuromuscular junction loss attenuate thus disease mechanism non cell autonomous mutant expressed motor neurons determining disease onset progression defined mutant acting within cell types
order test therapeutics functional assessments required pre clinical stroke research little consensus regarding appropriate behavioural tasks assess deficits especially testing extended times models short occlusion times small lesion volumes study comprehensively assessed different behavioural tests aim identifying show robust reliable stable deficits two months tasks regularly used stroke research useful examining striatal dysfunction models parkinsons disease two cohorts male wistar rats underwent model middle cerebral artery occlusion later resulted primarily subcortical small amount cortical damage animals tested along sham naive groups seven days one two months following behavioural testing brains processed striatal neuronal counts performed alongside measurements total brain white matter atrophy adjusting steps induced reliable assessing long term deficits transient middle cerebral artery occlusion model stroke
airway exposure lipopolysaccharide lps shown regulate type type helper cell induced asthma high doses lps derive immune responses low lps levels lead responses paper analyze mathematical model asthma regulation suggested modeling role tgf regulation phenotype lps driven immune system math show system undergo bifurcation steady state phenotype high lps levels presence time delays inhibition pathways two key regulators activities beta levels time delays affect phenotypic switches among phenotypes response time dependent lps doses via nonlinear crosstalk extended reaction diffusion model also predicts coexistence phenotypes various biochemical bio mechanical conditions heterogeneous microenvironment
boost converters indirect energy transfer topologies transient oriented controllers designed facilitate dynamic response range minimum time minimum output voltage deviation since analytical definitions control laws become quite complex large signal stability verification immediate paper explores existence stability indirect energy transfer converters controlled either boundary hybrid controllers introduces new simplified procedure examination large signal stability given converter load type using graphical analytical approach stability analysis examination method demonstrated boost converter loaded resistive load constant current load stability conditions verified using boost converter prototype controlled programmable deviation controller time optimal controller verifying large signal stability
pathophysiological changes associated alzheimers disease begin decades emergence clinical symptoms understanding early mechanisms associated pathology therefore especially important identifying disease modifying therapeutic targets majority clinical trials date focused anti amyloid beta beta treatments therapeutic approaches necessary ability monitor changes cellular networks include beta non beta pathways essential advance understanding subsequent development cognitive symptoms dementia metabolomics powerful tool detects perturbations pool metabolites reflects changes downstream genomic transcriptomic proteomic fluctuations represents accurate biochemical profile organism health disease application metabolomics help identify biomarkers early diagnosis discover novel therapeutic targets monitor therapeutic response disease progression moreover given considerable parallel mouse human metabolism use metabolomics provides ready translation animal research human studies accelerated drug design review summarize current progress application metabolomics animal models humans understanding mechanisms involved pathogenesis article part special issue entitled proteins mitochondrial dysfunction neurodegenerative diseases elsevier rights reserved
background knowledge available relationship obstructive sleep apnea cognitive impairment stroke limited evolution cognitive performance stroke sufficiently described methods prospectively enrolled examined acute stroke patients without previously diagnosed following information collected demographics sleep respiratory day seven month three month stroke post stroke functional disability tests entry months three cognition attention orientation memory verbal fluency language visual spatial abilities using revised cognitive examination ace months three results patients completing study diagnosed patients mean apnea index study entry spontaneously declined month group total ace score significantly reduced months three group poorer performance memory months verbal fluency months observed group compared non group visual spatial abilities non groups total ace score non groups improved conclusions high prevalence cognitive decline present patients acute stroke spontaneous improvements cognitive impairment observed elsevier rights reserved
one promising ways solving water problem world salt water thermal methods method competitive methods required thermal energy supplied recovering heat wastes energy systems gas turbine power plant paper combined cycle solid oxide fuel cell used thermal resource multiple effect system combination three system leads reduce total energy consumption reduce exhaust pollutants reduce operation maintenance cost increasing total efficiency comparison conventional individual systems analysis hybrid system performed find technical economical optimal working point system costs estimated effect two important design parameters operational temperature current density exergy efficiency cost electricity investigated implementing optimization system calculating optimal values design parameter leads rise exergy efficiency cost electricity decreased kwh elsevier rights reserved
background seasonal affective disorder sad subtype recurrent depressive bipolar disorder characterized regular onset remission affective episodes time year aim present study provide epidemiological data data socioeconomic impact sad general population methods conducted computer assisted telephone interview randomly selected subjects females males using seasonal health questionnaire seasonal pattern assessment questionnaire disability scale sds telephone numbers randomly drawn telephone books transformed using random last method last method employed choose target person interviews results subjects fulfilled criteria seasonal pattern according dsm diagnosed sad applying icd criteria fulfilled sad diagnostic criteria prevalence fall winter depression according criteria determined criteria fulfilled sad sad find statistically significant gender differences prevalence rates using dsm gold standard diagnosis sad diagnosis derived yielded sensitivity specificity subjects sad significantly higher scores sds higher rates sick leave days reduced productivity healthy subjects conclusions prevalence estimates sad lower data indicative substantial burden disease socioeconomic impact sad epidemiological data shows lack gender differences sad prevalence higher rates females clinical sad samples least part explained lower help seeking behaviour males elsevier masson sas rights reserved
background thoracic aortic major cause morbidity mortality worldwide pathogenesis medial degeneration aorta remains undefined high throughput analysis mass spectrometry useful elucidate molecular mechanisms involved formation identify biomarkers early diagnosis targets therapy purpose present study analyze secreted released proteins specimens aortic valve aortic valve patients methods aortic specimens collected patients undergoing elective surgery requiring graft replacement aorta sample aortic males aged years male years incubated serum free medium released proteins digested peptide mixtures nano high performance liquid chromatography analyzed mass spectrometry following identification differentially expressed proteins quantitative real time polymerase chain reaction qrt pcr analysis performed results comparison proteins released tissues showed significantly expression two groups patients bioinformatics analysis revealed differentially released proteins particular proteins regulated regulated respect proteins released related activation transforming growth factor tgf beta signaling latent tgf beta binding protein exhibited one highest significant expressions fold change respect qrt pcr analysis validated significant difference gene level conclusion hypothesis free profiling clearly showed expression patients confirming crucial role tgf beta signaling modulating development patients japanese college cardiology published elsevier ltd rights reserved
measurements used evaluate heat water vapor describe soil evaporation processes wide narrow runoff strips field rainwater harvesting system resulting shaped water vapor wide narrow runoff strips varied lower upper parts maize canopy wide runoff strips conditions extended lowest measurement level upper middle section inversion apparent top canopy virtual potential temperature theta profile showed difference middle section lower upper portion lower theta narrow compared wide strips changes observed respectively within canopy increased concentration determined wind order magnitude concentration reached peak kpa range wind speed value wide narrow treatments respectively sparse maize canopy wide strips supply drying power air response atmospheric demand compared narrow strips due variation air flow wide narrow runoff strips change gradients processes
alzheimers disease progressive neurodegenerative disease accumulating evidence suggests inflammatory response oxidative stress autophagy involved amyloid beta beta induced memory deficits flavonoid derived milk known activities study investigated neuroprotective effect beta injected rats results demonstrated significantly attenuated beta induced memory deficits water maze novel object recognition tests exerted effect beta injected rats determined elevated plus maze test attenuated inflammatory responses increased glutathione gsh levels decreased malondialdehyde mda levels upregulated autophagy levels beta injected rats conclusion potential candidate treatment anti inflammatory antioxidant autophagy regulating activities
studies examined relationship interpersonal stress body image young adults present experimental study tests effect peer stress general weight specific state body dissatisfaction moderating role gender appearance importance university students aged years randomly assigned three conditions peer stress elicited rejection scenarios based appearance personality rejection control results supported significant complex peer stress effect state body dissatisfaction moderated gender appearance importance specifically males personality based peer stress condition reported greater general body dissatisfaction compared males appearance based rejection conditions participants exposed appearance based peer stress including placing low value appearance reported greater weight dissatisfaction compared rejection control personality rejection conditions females participants reporting high appearance importance shown report greater body dissatisfaction general results hold implications prevention early intervention programs young adults suggest stress management training target peer domain population copyright ltd rights reserved
paper automatic control system robot tracking based camera designed hardware system idea modular design used selection cmos camera capture images use chip image processing running algorithm steering engine control board core realization serial communication dsp software algorithm design collected image needs processed median filtering binary processing identify boundary black line white board according gray value corresponding instruction called system make robot walking finally
trees highly regarded data structures text indexing string algorithms given string length vertical bar vertical bar tree takes nodes links often presented version latter digital search tree built process maximal chain nodes single arc tree requires labels encoded equivalent information contrary labeled single symbols theta nodes links tries worst case nodes interesting question stored using nodes present linear size guarantees nodes use new technique reducing number nodes stems results instance using linear size able check whether pattern length vertical bar vertical bar occurs log vertical bar sigma vertical bar time find longest common two strings vertical bar vertical bar vertical bar vertical bar log vertical bar sigma vertical bar time sigma elsevier rights reserved
hypothalamic hormone oxytocin plays major role regulation behavior body composition quality survival frequently impaired childhood patients due sequelae behavioral deficits severe obesity caused tumor treatment related hypothalamic lesions pilot cross sectional study analyzed emotion recognition abilities oxytocin concentrations saliva urine single nasal administration oxytocin patients four presented grade lesions limited anterior hypothalamic areas grade lesions involving bodies posterior hypothalamic areas emotional tasks assessed administration oxytocin using multimodal emotion corpus multidimensional mood questionnaire patients presented detectable levels oxytocin administration nasal administration oxytocin tolerated resulted increased oxytocin concentrations saliva urine oxytocin administration patients lesions limited anterior hypothalamus area showed improvements emotional compared patients lesions anterior posterior hypothalamic areas focusing correct assignments positive negative emotion categories patients improved assignment negative emotions oxytocin positive effects emotion perception patients specific lesions anterior hypothalamic area studies larger cohorts warranted
two dimensional vector features rendered terrain reference highlight features improve three dimensional scenes research proposes new screen space based method render solid color terrain using buffer value window coordinates screen space pixels spatial extent real world coordinates calculated pixels color changed spatial extent feature reflect fact going covering pixel compared existing methods method eliminates undesirable rendering artifacts parallel computing schema proposed implemented improve rendering performance
children greater risk adults developing cancer exposed radiation developing bodies long life expectancy post exposure children require specific attention nuclear accidents radiation used diagnosis treatment purposes review discuss carcinogenic potential pediatric exposures radiation accidental diagnostic therapeutic modalities particular emphasis given leukemia thyroid cancers consequences accidental exposures discuss evidence cancers arise result radiotherapy conclude review summary available literature links computer tomography carcinogenesis appropriate actions taken mitigate minimize negative health effects pediatric exposures radiation future considerations discussed
work consider minimum cost shared problem problem goal find minimum cost shared among multiple entities entity able establish cost efficient recently used literature establish shared functional modules protein protein interaction networks propose cut based formulation problem design two exact algorithmic approaches one based separation connectivity cut inequalities corresponding decomposition former model approaches enhanced various techniques including preprocessing stabilized cut generation iii heuristics cut management two algorithmic alternatives computationally evaluated compared previously proposed flow based formulation illustrate effectiveness algorithms two types instances derived protein protein interaction networks available previous literature access networks elsevier rights reserved
nearly years research focused large wood rivers provide basis understanding wood rivers wood breaks transported downstream least temporarily stable wood influences channel geometry fluxes water sediment organic matter abundance diversity aquatic organisms field based studies led qualitative conceptual models numerical river processes involving wood numerous important gaps remain however understanding wood dynamics majority research wood rivers focuses small medium sized rivers defined using ratio wood piece size channel width channels locally typical wood piece length small slightly longer wood pieces present medium although diverse geographic regions represented one studies region majority research comes rivers temperate forests regional commonly focus pacific northwest region north america studies originate consequently significant gaps understanding include lack knowledge wood related processes large rivers rivers rivers high low using wood budget organizing framework paper identifies gaps related wood recruitment transport storage influence dynamics respect wood recruitment lack information relative importance mass tree mortality transport buried wood channel diverse settings knowledge gaps related wood transport include transport distances thresholds mobility small medium rivers respect wood storage limited data longitudinal trends loads within large great rivers fluctuations load time intervals greater years knowledge gaps relate physical ecological effects wood including magnitude flow resistance caused patterns wood related sediment storage diverse river sizes channel geometry quantification channel interactions potential threshold effects relation physical processes biotic communities finally knowledge gaps related management large wood river including understanding consequences enormous historical reductions load rivers portions temperate zone effectively manage existing river includes enhancing public understanding importance addressing knowledge gaps requires case studies diverse rivers metadata analyses elsevier rights reserved
objectives melatonin levels decrease physiologically age possibly transition menopause plausible influence hormone therapy melatonin poorly understood aim randomized placebo controlled double blind trial investigate effect administration serum melatonin concentrations late premenopausal postmenopausal women study design analyses carried among late premenopausal postmenopausal healthy women participated prospective study finland serum melatonin sampled min intervals baseline months placebo main outcome measures melatonin levels secretion profile months compared placebo results mean melatonin levels mean melatonin exposure level area curve auc mean duration melatonin secretion differ months placebo reproductive state however postmenopausal women melatonin peak time delayed min average months placebo interaction time group detected melatonin level modelled treatment conclusions administration postmenopausal women alters melatonin peak time melatonin levels research larger clinical samples needed better understand effects melatonin profile elsevier ireland ltd rights reserved
investigate tear film stability secretion according serum levels dry eye patients retrospective observational study medical charts patients visited department university heart hospital april august reviewed serum levels measured subjects divided three groups according serum levels sufficient inadequate deficient group eye discomfort measured ocular surface disease index tear break time staining score tear secretion test measured resultsthe mean age mean serum level tear break time tear secretion positively correlated serum levels pearson correlation test tear break time tear secretion shorter vitamin deficient group compared sufficient group staining scores scores different three groups break time secretion correlated serum vitamin levels vitamin status important factor dry eye syndrome
south west asia including middle east one prone regions dust storm events recent years increase occurrence environmental meteorological phenomena remote sensing serve applicable method detect also characterise events study two dust enhancement algorithms used investigate behaviour dust events using satellite data compare numerical model output satellite products finally validate situ measurements results show use thermal infrared algorithm enhances dust accurately optical depth modis output dust regional atmospheric model applied comparing results ground based observations stations sun used validating satellite products find transport direction locations dust sources situations events model outputs presented comparing results maps model outputs showed using enhancement algorithms reliable way modis products model outputs enhance dust
paper new light weight highly engine creation methodology called demand engine suggested main feature method engine secret key kept created user system initiating transmission involved sides exchange design methodology structure system described using artificial neural network ann main building block system software hardware implementations suggested system performed prove also different experimental tests achieved determine impact suggested method network delay system performance
several years department mechanical energy management engineering collaboration performing researches exploitation tidal currents innovative turbine developed anchored coast require supporting structures reduces installation costs environmental impact machine latest version proposes use two rotating rotors order require small non existent stabilizing torque present work machine equilibrium conditions defined cfd analysis lift drag coefficients central calculated together final machine design procedure case study applying procedure machine installed energy output payback period estimated elsevier ltd rights reserved
gender stereotype theory suggests men generally perceived masculine women whereas women generally perceived feminine men several scales developed measure fundamental aspects gender stereotypes agency competence warmth although later version original sex role inventory included items masculine feminine addition specific gender stereotypical attributes argue useful able measure two core concepts reliable valid way introduce new brief scale traditional masculinity scale designed assess central facets self ascribed masculinity studies used known groups approaches participants differing gender sexual orientation validate scale provide evidence convergent validity expected reliably measured one dimensional masculinity construct moreover correlated moderately gender related measures demonstrating incremental validity predicted gender sexual orientation superior way established based measures furthermore connected criterion characteristics judgments straight whole sample voice pitch characteristics female subsample contact gay men male subsample outperformed gender related scales taken together long gender differences continue exist suggest provides valuable methodological addition research gender stereotypes
objective aim study retrospectively determine predictive factors decline forced vital capacity fvc initial using texture based automated quantification patients idiopathic pulmonary fibrosis ipf materials methods study patients ipf year follow pulmonary function tests enrolled study texture based automated system used house software quantify six regional patterns normal ground glass consolidation decline fvc defined decrease initial fvc results decline fvc occurred patients mean volume decline fvc mean consolidation patients follows respectively multivariate analysis revealed sole independent predictor decline fvc adjusted odds ratio roc analysis showed auc optimal cutoff value sensitivity specificity negative predictive value conclusion less extent accurately predict stable ipf year follow terms fvc
environmental present environment elemental inorganic organic compounds nervous system supposed key target toxicity research indicates selenium used protective agent neurotoxicity therefore aim review examine new implications molecular biology neurotoxicity specifically focus influence compounds interfering neurotoxicity molecular level form stable coordination compounds species characterized higher affinity groups compared groups therefore containing molecules targets binding least partially mediate biological outcome interaction molecular interaction elements also involves mutual interaction various experimental data demonstrate treatment modifies brain retention modulates neurotoxicity oxidative stress nervous tissue animals human data also indicate molecular interaction significant influence brain functioning neurodegeneration hypothesized effectiveness protection neurotoxicity determined dose elements particular chemical forms studies required estimate intimate mechanisms interaction vivo elsevier rights reserved
probabilistic design materials fracture critical components modern military turbine engines typical maximum design target risk component failures engine flight hour metric underscores essential role safety design process simultaneously achieve performance efficiency reliability throughout life cycle engine traditionally design life management approaches engine materials typically relied extensive testing programs produce large databases fatigue data statistically based life limits derived extrapolation mean fatigue behavior however found statistical behavior fatigue given test condition often exhibits form trends mean minimum fatigue lifetime typically respond differently loading microstructural variables circumstances underlying life limiting mechanisms appear exhibit probabilistic microstructural hierarchy fatigue resistance controlled susceptibility local microstructural neighborhoods early damage growth small cracks findings suggest significant opportunities exist reductions uncertainty materials life cycle prediction management hierarchies understood controlled paper explores potential implications findings number possible approaches suggested incorporating insights life limiting fatigue methods integrated computational materials engineering support optimized life cycle design materials components turbine engines benefits approach appear include substantial improvements model accuracy coupled reduced requirements materials testing potentially leading significant reduction time cost develop validate transition implement new fatigue resistant alloys published elsevier ltd
aims heme derived pro oxidative proinflammatory promotes occlusion murine models cell disease suggesting enhanced detoxification heme beneficial nuclear factor erythroid related factor transcription pathway principal cellular defense system responding pro oxidative proinflammatory stress drug approved treatment multiple sclerosis provides activating responsive genes hypothesized induction beneficial murine models results day vehicle methyl cellulose administered days mice occlusion hallmark measured mice dorsal inhibited inhibitory effect abrogated heme inhibitor tin increased nuclear responsive genes livers kidneys increased heme including heavy chain although plasma hemoglobin heme levels unchanged decreased markers inflammation including nuclear factor kappa adhesion molecules toll like receptor administered weeks decreased hepatic necrosis inflammatory cytokines shaped increased hemoglobin alter counts lactate dehydrogenase plasma heme spleen weights indicating beneficial effects attributable decreased innovation studies identify activation new therapeutic target treatment conclusion activates enhances antioxidant inhibits inflammation occlusion mice
control engineering mathematical model studied process plays important part representing mathematical model inherent errors due parameter variations define parametric structured uncertainties therefore differences mathematical model used design process real plant cases control system needs stabilize process also needs assure certain performances even presence uncertainties dynamics disturbance signals measurement noise make process vulnerable paper shows method behavioral modeling simulation gear system moment inertia friction coefficient represent parameters affected uncertainties expressed percentages nominal values modeled process considering classical controller tuned experimentally matlab used represent sensitivity functions time frequency domains nominal cases randomly generated samples worst case scenarios authors published elsevier ltd
spontaneous spreading frequent various forms human brain injury ischemic hemorrhagic stroke trauma outcome recently shown supply demand mismatch transients trigger spreading ischemic stroke examined mechanisms triggering recurrent spreading depolarization events many days hemorrhage despite large volumes hemorrhage induced injection fresh arterial blood rodents electrophysiological recordings detect single spreading depolarization hemorrhage cortical susceptibility spreading depolarization measured direct electrical stimulation topical application suppressed hemorrhage focal cerebral ischemia experimentally induced hemorrhage revealed change propensity develop peri spreading frequency peri spreading decreased increased normalized days hemorrhage compared sham controls however ischemic tissue neurological outcomes significantly worse hemorrhage even peri spreading depolarization frequency reduced laser implicated cerebrovascular hemodynamic mechanisms worsening outcome altogether data suggest cerebral ischemia required spreading triggered hemorrhage creates cycle leading delayed cerebral ischemia syndrome
susceptibility evaluation vital disaster management development planning yangtze river three reservoir area study support remote sensing geographic information system factor groups comprising separate related data layers selected establish susceptibility evaluation model based back propagation neural network including slope aspect plan curvature distance faults land use land cover normalized difference vegetation index normalized difference water index distance roads effect rivers model development three layered interconnected neural network structure input layer hidden layer output layer used evaluating susceptibility time back propagation algorithm applied calculate weights input layer hidden layer hidden layer output layer results showed effect slope highest weight value two times factors followed effect rivers end susceptibility evaluation area divided four zones high high moderate low susceptibility verification receiver operating characteristic curve back propagation neural network derived susceptibility evaluation model drawn results showed area receiver operating characteristic curve prediction accuracy furthermore results obtained article verified comparing existing historical data multiple field verified results lastly susceptibility map help decision makers risk management site selection site planning design control engineering
offer general procedure design select unit based internal combustion engine work devoted provide numerical model estimate amount generated power recovered heat based engine performance features evaluated mismatch numerical results available computational published values also evaluated presented design unit economically technically finally grey systems theory proposed multi decision making strategy determine optimal engine applying numerical model vehicles engines provides efficiency power heat production characteristics engine observed optimum operation system chosen case separately generally using several smaller engines parallel mode preferred single large engine due two major enhancements achieved former scenario longer operation period full load operation reliability level improvement elsevier ltd rights reserved
flow pattern map liquid liquid system circular experimentally investigated varying angle degree inlet fluids experimental results showing distinguishing nature transition boundaries established using graphical interpretation investigations carried find better objective flow pattern indicator vast flow pattern observations studies advanced feed forward back propagation networks radial basis networks ann ann showed generalized regression neural network showed better prediction prediction techniques value relative impact input variables angle superficial velocity superficial velocity water flow pattern formation found respectively discrete continuous time state space models system also developed interpreted detail using system identification technique better understanding system elsevier rights reserved
microbiological control cosmetic products always interest industry since microbial lead product degradation potential human health hazard added control microbial increase shelf life product prevent infection humans however safety cases environmental impact questioned often growing interest develop free self preserving cosmetic formulations self preserving products traditional replaced multifunctional cosmetic ingredients apart delivering main functional property also exhibits antimicrobial property paper explores use combination multifunctional cosmetic ingredients leave skin care products deliver safe product products studied emulsion based cream cream cosmetic ingredients screened antimicrobial property compared known skin care ingredients various combinations used prepare cream cream formulations evaluated efficacy preserve product microbial challenge challenge test multiple weekly challenge formulation used control formulations screened cream cream formulations passed criteria similar control formulation possible develop different options self preserving skin care products efficacious products
given graph resistance distance two nodes resistance one measure two nodes electrical network edges resistors distances pairs nodes yields called index graph measures overall connectivity work consider random graphs since graphs random indices random variables give formulas expected value index show concentrates around expectation achieve studying trace graphs synchronization class estimation problems graphs results imply acquiring pairwise measurements uniformly random good strategy even proportion measurements acquired elsevier rights reserved
aim measure high statistics flux arrival directions mass composition rays highest energies since collaboration added three new high elevation heat along new array field view new enhancements lowered energy threshold order magnitude combination existing vertical field view extended allowing measurement nearby air arising energies low paper describe new front end analog board developed process signals generated heat eighty analog boards produced fully characterized tested main characteristics electronic circuits circuit parameters illustrated elsevier rights reserved
foster care preferred alternative home care necessarily beneficial foster childrens psychosocial functioning dilemma leaves researchers challenge find factors related foster childrens social emotional functioning sample dutch foster children examined extent three clusters characteristics foster child foster family foster placement related foster childrens functioning time research multivariate three step hierarchical regression analyses performed three outcome variables externalizing problems internalizing problems prosocial behavior found three clusters foster care characteristics significantly related foster childrens functioning foster placement characteristics particular interventions aimed foster children explained largest amount variance behavior problems children receiving interventions externalizing internalizing problems possible explanation interventions indicated foster children highest need additional support prosocial behavior particularly related foster family characteristics results mostly line international research careful screening monitoring social emotional functioning foster children help identify problems early stage addition preventive support offered foster children families need elsevier ltd rights reserved
eosinophils constitute important component immunity associated various allergies also linked disorders including skin disease psoriasis demonstrate functional relationship eosinophils dendritic cells related skin diseases previously showed neutrophil extracellular nets psoriatic skin demonstrate eosinophils found psoriatic skin near neutrophils nets suggesting responses regulated eosinophils eosinophils inhibited function vitro mechanism involve cell contact depended soluble factors stimulated specific net components conditioned media attenuated production interferon ifn alpha affect maturation evidenced expression molecules ifn alpha play key role autoimmune skin inflammation data suggest eosinophils influence responses impact production ifn alpha
upgrade discharge control system dcs distributed real time control system executing complex control monitoring tasks now dcs control algorithms implemented coding dedicated application processes programming language algorithm changes required code modification experienced programmers perform significant constraint flexibility control system operation design new approach extends dcs capability configuration defined control algorithms composed chains small configurable standard function blocks providing general purpose functions like algebraic operations filters feedback controllers output decision logic later phase graphical help modify configuration simulink like fashion building algorithms standard functions result high number elements order achieve similar performance coding essential avoid administrative bottlenecks design consequence dcs function block chain context single real time thread application process issues multi context need considered resulting strongly simplified signal handling zero performance overhead inter block communication instead signal driven synchronization block derives execution sequence automatically block dependencies defined configuration blocks connecting signals dynamically based definitions configuration file algorithms thus defined code configuration concept developed view simulink block libraries general application modules extends dcs distributed computing multi growing diversity general purpose blocks dcs framework reach unprecedented degree flexibility configuration defined algorithms gradually replace many existing dcs applications finally concept also become interest upcoming plasma control system elsevier rights reserved
care pediatric surgical patients limited pediatric facilities perioperative basic understanding specialized care children require knowledge set includes understanding basic terminology used describe patient population developmental stages pediatric patients preoperatively nurse conduct thorough assessment evaluation address questions patient parent nurse prepared help manage difficult induction difficult access positioning skin care surgical site preparation postoperative care considerations include addressing airway differences vital signs pain assessment management fluid management preparation discharge awareness anatomic physiologic differences developmental stages surgical needs children allow perioperative provide high quality safe care pediatric surgical patient inc
introduction testosterone deficiency metabolic syndrome mets strongly associated patients sexual dysfunction testosterone deficiency providing valuable opportunity assess mets identification variables predicting mets great importance identify cardiovascular comorbidities risk factors including erectile dysfunction associated mets men aged total testosterone calculated free testosterone gain insight relationship conditions collected multicenter cross sectional observational study conducted spain among men visiting mens health care offices confirmed diagnosis testosterone deficiency subjects data mets assessment included analysis data available toxic habits cardiovascular comorbidities diagnosis values main outcome mets definition used waist circumference threshold diagnosed classified using international index erectile function questionnaire bivariate multivariate logistic regression analyses performed calculate odds ratios ors mets results mean age years mets respectively increasing age bivariate analysis showed moderate severe obesity peripheral vascular disease variables associated greatest odds mets respectively followed alcohol intake tobacco use testosterone deficiency severity minimal effect disappeared multivariate analysis elevated triglycerides hdl cholesterol mets risk factors associated lower level conclusion high prevalence mets among men testosterone deficiency highlights opportunity assess cardiovascular health patients sexual dysfunction moderate severe obesity alcohol intake significantly increase likelihood mets metabolic syndrome men low testosterone levels relationship cardiovascular risk factors comorbidities erectile dysfunction sex med
advanced materials potentially enhanced accident tolerance yield different light water reactor performance safety characteristics present based alloys differences due material properties reactor physics thermal hydraulics characteristics differences reactor physics driven fundamental properties neutron absorption cross section iron iron based also design modifications candidate materials larger fuel compensate parasitic absorption paper describes three dimensional nodal kinetics simulations reactivity initiated accident representative water reactor iron aluminum silicon fiber silicon ceramic matrix composite sic sic materials study shows similar behavior sic sic configurations versus reference however response indicates similar energy deposition shorter pulses higher magnitude due shorter neutron generation time core models based based cases exhibit rapid fuel thermal expansion rate cases resultant interaction occur rapidly conclusions paper based limited set simulated super prompt transients elsevier ltd rights reserved
background believed potentially harmful shoulder therefore purpose study evaluate anatomy ligament symptomatic non elite junior players high resolution ultrasound methods august september symptomatic non elite junior players mean age standard deviation control group age sex matched subjects included shoulder assessment customized standardized protocol performed body mass index dominant arm years practice weekly hours training weight eastern western semi western kind strings recorded results abnormalities found ultrasound players two players two ten thickness resulted comparable dominant non dominant arms multivariate analysis demonstrated association present among thickness variables evaluated control group abnormalities found ultrasound subjects sub statistically significant differences players control group found conclusion symptomatic non elite junior players minor shoulder abnormalities found
bridge design three tower suspension bridge main span fatigue analysis bridge necessity design ensure safety functionality paper fatigue life assessment proposed considering load effect resistance load effect calculated random traffic model based monte carlo simulation finite element model established ansys random vehicle load spacing simulated model traffic volume predicted resistance calculated according corrosion effect also taken consideration using curves steel wires noted paper influence lines wide range load effect shared fatigue life three tower suspension bridge much longer lifetime corrosion effect considered corrosion big impact fatigue life length associated fatigue damage two ends three tower suspension bridge side span suffer largest fatigue damage
paper presents methodology applied present time teaching evaluation different courses area manufacturing processes engineering university context use content management systems continuous evaluation learning particular platform used structuring contents continuous evaluation courses scope materials science manufacturing processes automation operations analysis changes challenges derived adoption methodology different courses applied presented changes slightly different function optional character courses depending number students enrolled
studied human vivo metabolism delta natural commonly occurs human environment four healthy human volunteers orally exposed single dose volunteer gave one urine sample administration subsequently collected urine sample within administration concentration proposed metabolites delta delta carboxylic acid acid delta determined using specific sensitive procedure metabolites investigated using scan analyses detected urine sample maximum concentration administration whereas detected samples renal excretion kinetics showed elimination half life cumulative excretion within exposure correlated applied dose scan analysis indicated several additional human metabolites thereof six spectra enabled prediction corresponding chemical structure results study indicate relevant product human vivo metabolism oxidation methyl group proceeds acidic structure without interruption thus generation alcoholic intermediate appeared rate determining step metabolic route nevertheless proportion metabolism low oxidative metabolites likely hypothesis confirmed discovery additional human metabolites whose predicted chemical structures fit oxidative products metabolism
recent research demonstrated people especially susceptible development suggested misinformation causal role explains known outcome however little known factors associated witnessed outcome impact likelihood false memory development present study outcome valence negative positive neutral manipulated participants heard several short stories contained outcome getting promoted lacked causal explanation participants subsequently exposed suggested causal misinformation explained outcome performed impressive act previous day tested memory original event results indicated participants reported suggested causal information explained either positive negative outcome opposed neutral outcome theoretical practical implications findings discussed
background traditionally engineering curricula electrical circuits use instruction hands lessons effective approaches teaching terms definitions procedural use formulas build circuits nonetheless students often lack conceptual understanding purpose hypothesis aim study discover facilitate acquisition conceptual understanding hypothesized adding instructional approach form inquiry learning virtual lab effective relying traditional instruction alone design method students secondary vocational engineering education randomly assigned one two conditions quasi experimental study traditional condition curriculum supplemented computer based practice virtual lab condition traditional curriculum supplemented inquiry learning virtual lab results results showed students virtual lab condition scored significantly higher conceptual understanding cohens procedural skills particular students condition scored higher solving complex problems result occurred complex conceptual procedural problems conclusion since students virtual lab condition acquired better conceptual understanding also developed better procedural skills students traditional condition appears conceptual understanding procedural skills develop iterative fashion
improved energy efficiency one effective strategies achieving energy sustainability independence locally globally industry accounts global energy usage year suggests potentially significant impact overall energy use rapid development standards efficient equipment components manufacturers towards improvements component level however shown largest efficiency potential actually found higher system levels components serve production processes ventilation hydraulic systems even though importance increasing energy efficiency systemic level widely acknowledged recent years practical approaches seldom discussed literature gap aspiration achievement calls development new approaches foster system efficiency industrial systems paper presents systems analysis corresponding model increase energy efficiency industrial processes involve intensive usage electric motor systems model traditional value stream mapping three case studies representing three different industrial processes conducted develop validate model total energy efficiency measures identified address actions beyond component levels alongside energy efficiency measures model promotes creation conditions cross functional worker participation applying model knowledge skills gained industrial personnel working improved energy efficiency maintenance production processes used immediately generate improvement suggestions paper concludes model based simplified energy focused value stream mapping broaden scope energy efficiency actions engage larger group workers within organisation increase systems efficiency used practical tool finding continuous improvement possibilities result strengthened competitiveness cost effective sustainable manufacturing elsevier ltd rights reserved
background intestinal fibrosis formation common feature inflammatory bowel disease ibd leads significantly impaired quality life affected patients intestinal obstruction need surgical intervention constitutes major treatment challenge key messages fibrosis results response gut tissue chronic inflammation similarly occurs organs underlying mechanisms complex dynamic involving multiple cell types interrelated cellular events large number soluble factors owing breakdown epithelial barrier ibd luminal bacterial products leak induce innate immune response mediated activation immune non immune cells environmental factors chronic inflammation certainly impact quality quantity intestinal fibrosis finally composition intestinal extracellular matrix dramatically altered chronic gut inflammation actively promotes fibrosis mechanical properties conventional view intestinal fibrosis inevitable irreversible process gradually changing light improved understanding cellular molecular mechanisms underline pathogenesis addition clinical observations patients undergo shown formation reversible conclusions identification unique mechanisms intestinal create practical framework target block specific pathways estimate risk fibrotic complications permit detection early fibrotic changes eventually allow development treatment methods customized patients type degree intestinal fibrosis karger basel
result power train electric hybrid vehicles electromagnetic compatibility vehicles comprehensively affected especially power electronic components operated battery voltages around produce broadband inside vehicle prove compliance normative requirements considering vehicles inner measurements component level used testing drive inverter requires electric motor load mechanically loaded another inverter driven system possibly affecting measurement load torque generated outside chamber mechanical connection two drives wall quite difficult realize thus work passive load developed modeling impedance behavior existing motor thus setup load torque generation used drive inverters test setup according circuit realized model load drive inverters typically used electric vehicles finally results measurements passive network modeled drive compared
production decline analysis considered robust method obtain flow parameters reservoir properties original gas place although advanced production decline analysis methods vertical wells wells horizontal wells conventional reservoirs widely used production decline type curves multi horizontal wells considering stimulated reservoir volume gas reservoirs yet compared conventional gas reservoirs multi flow mechanisms flow diffusion adsorption desorption complex flow behaviors exist gas reservoirs bringing big challenge analyzing rate decline performance wells thus paper based material balance equation consideration adsorption desorption material balance pseudo time decline type curves modified extend theory production decline analysis gas reservoirs considering nonlinearity caused gas desorption diffusion complex flow numerical method applied paper obtain type curves based perpendicular grids numerical model considered developed solution obtained using control volume finite element method fully implicit method type curve validated simplify model production decline type curves considering gas reservoir plotted computer programming five flow regimes including early formation linear flow early radial flow compound linear flow second radial flow pseudo steady flow recognized compared modified type curves presented paper ones traditional pseudo time tendency underestimate value normalized rate normalized cumulative production normalized integral derivative cumulative production reserve effects relevant parameters including radius outer region radius permeability region outer region langmuir pressure langmuir volume diffusion coefficient type curves analyzed work expands understanding flow behaviors gas reservoirs used estimate reservoir properties types reservoirs elsevier rights reserved
study evaluated ambient noise effect offshore aquaculture systems oxidative status immune parameters sea experiment performed days two different acoustic stimuli offshore aquaculture noise condition created typical acoustic field proximity offshore sea cage fish farming using random sequence quite sea background noises aquaculture noise condition represented acoustic field inside open concrete tank fish farming third group without acoustic projection used control days beginning acoustic noise fish exposed offshore aquaculture condition showed significantly higher levels total oxidant status activity activity white blood cells together lower albumin globulin ratio comparison fish control group whereas fish exposed condition showed analytical data placed groups though never significantly different results demonstrate offshore aquaculture noise particular sea adversely influences oxidative status immune function sea determining mild stress condition affect sea welfare
wheat grain one worlds major food crops recent advances wheat genome sequencing now facilitating genomic proteomic analyses however little known possible differences total protein levels versus wheat cultivars also knowledge phosphorylated wheat proteins still limited performed detailed analysis proteome leaves two wheat cultivars one wheat proteomics data revealed whereas observed significant differences overall high similarity varieties respect protein abundance observed addition already stage small set proteins differential small larger wheat cultivars potentially act growth predictors finally identified study retrieved house developed plant making first repository phosphorylated wheat proteins way depth quantitative proteome wide differential analyses upon specific trigger environmental change
sustainability balanced approach puts equal focus environment economy society research suggests worker health safety integral dimension social sustainability present research contributes body knowledge assessing quantifying classifying occupational health safety risk associated construction operation maintenance sustainable projects across united states construction industry compares risk encountered counterpart projects researchers conducted credit credit review leadership energy environmental design leed rating system evaluate potential positive negative impact green design elements construction practices associated implementation leed credits construction maintenance workers researchers also quantified risk associated leed credits green projects distributed across united states results show even though large number leed credits neutral toward sustainable construction represented leed projects associated increase base level safety risk finally risk model integrated risk plane analysis classify safety risk associated leed credits risk classification analyses indicate two credits associated risk across united states construction industry expected findings research benefit safety professionals academics designers construction stakeholders providing evidence chosen sustainable designs impact building projects american society civil engineers
identifying origins social bias critical strategies overcome prejudice two experiments tested hypothesis young children novel social biases brief exposure biased nonverbal signals demonstrated adults results consistent hypothesis experiment found children exposed brief video depicting nonverbal bias favor one individual another subsequently explicitly preferred prone behave toward target positive nonverbal signals moreover experiment preschoolers generalized bias individuals spread bias observed experiments critical foundation understanding way social biases develop spread early childhood
research rainwater harvesting mainly focuses building scale scant information available performance large scale study aims determine potential economic viability meeting non potable water demand rainwater harvesting large scale case dynamic model developed analyse scenarios varying rainfall catchment surfaces storage capacity four potential system configurations non potable uses analysed economic performance different water prices storage options study found given sufficient storage catchment size non potable water demand supplied reducing drinking water demand returns adding storage catchment system make full supply inefficient current water charges make large scale system configurations viable due high investment costs supply networks storage infrastructure
gamma glutathione gsh precursor rich peptides play important role heavy metal detoxification plants microorganisms complex formation gsh investigated absorption jump kinetics complex formation induces ligand metal charge transfer bands absorption spectral range implies formation coordination bond metal groups absorption spectra experiments allow determination affinity constants complexes show three interact form complexes similar affinity constants log similar log similar affinities independent number moreover lower determined complex formation hand complexes detected furthermore complex stable affinity constant log similar kinetic studies indicate complex formation gsh occurs range direct rate constant reverse rate constant thus encapsulated silica matrix good candidates heavy metal detection elsevier ireland ltd rights reserved
purpose review purpose study review literature perinatal intimate partner violence focusing recent knowledge guide mental health professionals best approaches identify treat women exposed perinatal intimate partner violence recent findings risk factors individual victim factors include relationship community societal factors interact together better information now available identify document treat women exposed violence around time conception pregnancy postpartum period summary recent information helps psychiatrists mental health professionals assist women exposed violence related perinatal period however research needed provide improved evidence optimal interventions better patient outcomes
present study investigated true false memory manifestations adaptive maladaptive using drm deese roediger mcdermott word lists paradigm ninety seven college students administered drm paradigm completed almost perfect scale revised rice signal detection analyses revealed associated accurate memory whereas concerns associated higher levels false memories higher confidence ratings accuracy memories moreover individuals high concerns manifested lower memory discriminative ability suggesting poor working memory capacity findings corroborate previous studies suggesting working memory involvement false memories call investigation cognitive emotional processes underlying false memories elsevier ltd rights reserved
parkinsons disease heterogeneous neurodegenerative disorder variable phenotypes underlying clinical phenotype unique set motor symptoms frequent initial motor symptom difficult symptom treat nucleus deep nucleus cerebellum involved study test hypothesis iron elevated dominant patients using quantitative susceptibility mapping forty three patients dominant rigidity dominant healthy gender age matched controls recruited multi echo gradient echo data collected subject system inter group susceptibility differences bilateral investigated correlations clinical features susceptibility also examined contrast dominant group group found increased susceptibility bilateral compared healthy controls addition susceptibility positively correlated score drug naive patients findings indicate iron load within make important contribution motor phenotypes moreover results suggest dominant phenotypes differentiated basis susceptibility least group level copyright john wiley sons ltd
cognitive radio transform domain communication system proposed support reliable communications low probability however research assume perfect synchronization simplify algorithm design paper present low complexity symbol timing offset carrier frequency offset estimation method practical applications utilizing consisted multiple identical training sequences estimated procedure cyclic code shift circular correlation performed utilizing fast fourier transform fft thus estimation procedure significantly simplified considerable complexity reduction analyzed compared two conventional methods simulation results demonstrates proposed estimation scheme low complexity solution channels comparable estimation performance terms probability incorrect timing offset mean square error
social anxiety disorder sad antisocial personality disorder aspd often thought comorbid however recent research suggests existence sad subtype characteristics atypical sad common aspd thus explored two competing hypotheses sad aspd represent opposite ends single dimension sad aspd exist two separate dimensions positively correlated data obtained national epidemiological survey alcohol related conditions sad aspd related greater impairment psychiatric comorbidity either disorder alone sad aspd group also likely seek treatment sad symptoms drink antisocial acts sad group presence sad individuals aspd vice versa appear provide protective benefits sad aspd appear two separate correlated disorders elsevier ltd rights reserved
purpose goal rct examine efficacy safety web based program improve cardiovascular bone health outcomes among breast cancer survivors underwent prophylactic thus experienced premature surgical menopause methods month commercially available web based lifestyle modification program precision nutrition coaching utilized cardiovascular fitness dietary intake leisure time activity body composition bone mineral density bone structure muscle strength assessed results average adherence program components women intervention group maintained cardiovascular fitness level months control group significantly decreased fitness capacity significant difference groups percent change whole body bone area control intervention also observed decreased bmi fat mass intervention group due significant concomitant decreases caloric intake increases caloric expenditure control group demonstrated decreased caloric intake decreased lean tissue mass conclusions population high risk detrimental cardiovascular bone outcomes commercially available lifestyle intervention program mitigated decline cardiovascular health improved bone health decreased weight fat loss
background total hip arthroplasty frequently performed despite low complication rates play important clinical economical role aim study identify comorbid diseases patients undergoing primary potential influence survival hip patients material methods total patients included retrospective study reviewed took place hospital within one year primary implantation comorbid diseases detected administrative data using definition includes thirty diseases cox regression model fishers exact test used examine correlations comorbidities risk revision results patients required operation within first year surgery presence one analysed comorbidities associated greater risk revision deficiency anemia obesity drug abuse alcohol abuse fluid electrolyte disorders peripheral vascular disorders associated increased risk revision comparisons conclusion total number comorbidities specific comorbid diseases independently associated increased risk operation within first year total hip arthroplasty information helpful pre post operative risk adjustment patient selection
sustained controllable release insulin strongly required achieve ideal treatment diabetes previously developed self assembly retaining activity technology via host interaction beta insulin resulting insulin termed insulin far also demonstrated covalently insulin forms technology present study designed evaluated combination system technology technology achieve sustained controllable release system insulin insulin formed alpha gamma addition insulin provided sustained controllable release insulin beyond single technology vitro vivo results suggest combination system technology technology useful design sustained controllable release system insulin elsevier ltd rights reserved
paper collected chinas green building projects completed intelligent application information technology intelligent technology application situation comparison analysis intelligent technology use green building country present compared papers article just single building application smart technology analyzed regional angle regional green architecture application intelligent technology china classified contrast better show use intelligent technology green building time also different areas green building project participants comparison screening green building projects smart technology provides meaningful reference
often deployed remote hostile environments wireless sensor networks vulnerable various types security attacks possible solution reduce security risks use directional antennas instead ones conjunction due increased complexity higher costs larger sizes directional antennas traditionally used wireless sensor networks recent technology trends support method paper surveys existing state art approaches field offering broad perspective future use directional antennas mitigating security risks together new challenges open research issues
background prior research repeatedly shown alcohol dependence associated large range impairments psychological processes lead interpersonal deficits specifically suggested interpersonal difficulties reduced recognition sharing others emotional states however pattern deficits remains clarified study thus aimed investigate whether alcohol dependence associated impaired abilities decoding contextual complex emotions altered sharing others emotions methods forty one alcohol dependent individuals matched healthy individuals completed multifaceted empathy test instructed identify complex emotional states expressed individuals contextual scenes state extent shared results compared healthy individuals impaired identifying negative cohens positive cohens emotional states conversely presented preserved abilities sharing others emotional states conclusions study shows alcohol dependence characterized impaired ability complex emotional states positive negative despite presence complementary contextual cues preserved emotion sharing therefore results extend earlier data describing impaired ability emotions toward ecologically valid emotional states also indicate essential emotional competences emotion sharing preserved alcohol dependence thereby offering potential therapeutic
clearance oxidative stress compounds critical protection organism malignancy key physiological process regulated fully understood found expression characterized tumor suppressor lung cancer elevated colorectal cancer tissues patients cancer cell lines colitis associated cancer model mice found deficiency reduced cell proliferation increased cell apoptosis inhibited tumorigenesis vivo rna seq transcriptome analysis identified oxidative stress associated pathways dysregulated moreover deficient cells mouse tissues oxidative agents reduced partially due increased glutathione gsh level mechanistically regulates mediated expression predominant enzyme generation administration disulfide form deficient cell lines inhibited activity leading reduction gsh level increase cell growth taken together studies suggest potential biomarker colon cancer promotes tumorigenesis stimulation expression oxidative stress colitis associated cancer study revealed unexpected oncogenic role colorectal cancer suggesting complicated functional molecular mechanism differences gene distinct tissues new colorectal cancer crc positively associated chronic inflammation major feature increased production reactive oxygen species ros capable inducing potentially malignant changes cells molecular pathways associated changes however fully elucidated retinoic acid induced protein coupled receptor identified potentially oncogenic player crc whereby elevated expression leads dysregulation pathways responsible clearance oxidative agents deficiency associated reduced cell proliferation human cancer cell lines diminished tumor progression mice
autism spectrum disorder asd pervasive neurodevelopmental condition characterized variable impairments communication social interaction restricted interests repetitive behaviors heterogeneity presentation hallmark investigations immune system problems asd including aberrations cytokine profiles signaling increasing recent times subject ongoing interest aim establishing whether cytokines utility potential biomarkers define subgroup asd function objective measure response treatment review summarizes role immune system discusses relationship immune system brain behavior presents previously identified immune system abnormalities asd specifically addressing role cytokines aberrations roles identification biomarkers also addressed particularly respect cytokine profiles asd
dairy largest source nitrate oxide emissions urine excreted animals additional application urine patches fertilizer increase losses identification urine patches reduce losses efficient fertilizer application improved fertilizer use efficiency aim study determine remote sensing using light detection ranging lidar technology accurately identify urine patches based height variation grass canopy close proximity synthetic urine applied two blocks established new zealand recent exposure animals fertilization urine patches scanned weekly five weeks lidar based contour maps shown accurately detect asymmetric urine patches calculate percent area urine based high early one week simulated event authors published elsevier
aims derivatives drug also possess anticancer properties ability detect uptake distribution cells facilitate live cell imaging without labelling study describes mid range infrared absorption spectra three variants attempts detect presence simple cell model cytotoxicity assays assess potential anticancer properties bladder cancer cells methods mid range fourier transform infrared spectra obtained dry preparations dha art prepared normal blood incubated degrees three derivatives preparations prepared spectroscopy potential growth inhibition bladder carcinoma cell line assessed bromide residual viable biomass method results spectra obtained three native compounds repeat scans showed art stable stored manufacturers recommendations dha exhibited marked changes period possible detect dha art fit spectrum native compound dha art showed strong cytotoxic potential cells conclusions derivatives tested exhibit unique mid range infrared absorption spectra used monitor degradation dha detected loaded rendering future imaging studies feasible cytotoxic efficacy cells suggests bladder cancer possible target disease
architectural project review perception near surrounding ground important evaluation virtual environment near surrounding ground missing using wall screens address problem suggest increasing vertical field view one solution use rendering approach non planar projection however simply increasing rendering leads much distortion suitable architectural project review propose new hybrid projection combining perspective projection center screen cylindrical like projection top bottom increase without large deformations preserve perception distances allow seeing surrounding ground also report results experiment conducted evaluate distance perception projection
background malaria disease caused parasites genus transmitted female major cause morbidity mortality loss productivity humans county prone seasonal transmissions malaria mostly rainy seasons methods cross sectional study used mixed methods approach collect data knowledge lay management malaria questionnaire survey administered respondents qualitative data collected focus group discussions four ecological zones covering north south sub counties county analyses done summary statistics quantitative data content analysis qualitative data results study communities malaria signs symptoms cause seasonality biomedical knowledge existed local perceptions knowledge however influence first second choice treatments compliance medication respondents reported suffered malaria onset suspected malaria case community members reported following visited health facility used herbal treatments malaria medicines counter malaria medicines traditional treatments nearly respondents reported visiting health facility subsequent treatments herbal treatments comprised derived roots leaves plants believed medicinal value compliance conventional malaria treatment regime however identified challenge malaria management quick relief symptoms undesirable qualities like drug bad undesirable side effects nausea long regimen treatment contributors non compliance men women exhibited different health seeking behaviours based cultural expectations masculinity gender roles acceptability health services conclusions knowledge malaria important identifying disease necessarily lead good management practice treatment seeking behaviour also influenced perceived cause severity disease timing anticipated cost seeking treatment gender besides availability traditional conventional medicines
power generation biomass use spark ignition engines requires cooling biomass avoid knock cooling leads condensation critical process components leading significant maintenance issues costs conventionally related problems addressed optimizing process along developing purification systems result increased investment maintenance costs novel method developed entire process exit biomass combustion loaded internal combustion engine carried temperature degrees thereby avoiding condensation consequent problems homogeneous charge compression ignition engine utilized high intake temperature operation paper describes first experiments hot biomass produced two stage engine without intermediate cooling purification steps objective experiment test stability engine response naturally occurring random variations composition experiments carried continuous period indicated efficiencies around bar observed emissions nox relatively high probably due presence ammonia implementation closed control loop combustion feedback parameter rate controlled parameter ensured stable operation experimental duration elsevier rights reserved
industrial linear drive systems many components due prolonged operations harsh working environment one components degraded causing regular fault occurrences situation action taken system collapse therefore quite important studying fault detection fault tolerant control control engineering paper fault tolerant control scheme based monitoring information proposed linear drive systems fault detection algorithm first presented subsequently fault identification developed finding characteristic detected fault finally fault tolerant controller discussed based soft computing
recently lot researches focused identity based encryption advantage scheme reduce cost public key infrastructure simplifying management although innovations one weaknesses key problem private key generator decryption keys identities consequently based encryption scheme proposed provides solution key problem allowing certification authority possess partial decryption key comprises full decryption key together user generated private key paper propose new schemes without pairing prove chosen attack secure random oracle model based hardness computational problem compared schemes schemes significantly efficient terms performance makes schemes suitable computation limited node sensor wearable device networks copyright john wiley sons ltd
nuclear thermal propulsion viable option human exploration deep space high thrust improved specific impulse established technology capability enhanced mission safety reliability technology already investigated tested united states america russia former union representative nuclear engine vehicle applications type reactors traditionally used highly enriched fuels shaped hexagonal fuel element geometries importance making high power reactor minimum size although designs best choice terms performance technical maturity inevitably provoke nuclear proliferation obstacles research development activities non nuclear states also potential overcome security issues due non proliferative small size engine low thrust levels similar korea advanced nuclear thermal engine utilizing low enriched fuel designed future generations design goals make use fuel fairly compact core minimize performance relative traditional achieve goals new space propulsion reactor conceptually designed key concepts high density fuel resistance high heating corrosion thermal neutron spectrum core compact integrated fuel element core design protective cooling capability addition preliminary design study thermal hydraulics performed explore design space new reactor concept result indicates innovative reactor concept great potential implement use fuel create comparable performance compared existing designs elsevier ltd rights reserved
background purpose study characterize risk cancer large cohort patients primary syndrome methods analyzed development cancer consecutive patients fulfilling classification criteria baseline clinical immunological characteristics systemic activity scores assessed diagnosis predictors cancer using cox proportional hazards regression analysis adjusted age diagnosis gender sex age specific standardized incidence ratios cancer estimated spanish mortality data results mean follow months patients developed cancers frequent type cancer cell lymphoma including non cell lymphomas systemic activity diagnosis primary correlated risk hematological high risk either cell non cell lymphoma subtypes patients high risk non cell non cell cancer low levels high risk lymphomas monoclonal low levels high risk non lymphomas estimated solid cancer hematological cancer specific cancers multiple diseases hodgkin lymphoma non hodgkin lymphomas thyroid cancer cancers oral cavity stomach cancer conclusions one third cancers developed patients primary cell lymphomas prognostic factors identified diagnosis differed according subtype cell lymphoma developed primary also associated development non hematological cancers thyroid oral cavity stomach
article new easy implement dimensional chaotic system developed dynamic attitudes analyzed following analogue circuit implementation system done pspice simulation real circuit components finally micro controller based random number generator new chaotic system used also passed randomness tests designed furthermore user interface designed help matlab helps computer check designed random number generator presented elsevier gmbh rights reserved
experiments computer teaching process often need use number operating systems often computer room common operating system maintenance engine room brought difficulties traditional experiments build virtual experimental platform complete basis virtual machine technology improve use engine room also release tedious maintenance work therefore important practical value
purpose review purpose study review recent randomised controlled trials coronary computed tomography angiography patients stable coronary artery disease recent findings initial results subsequent papers heart computed tomography heart promise prospective multicentre imaging study evaluation chest pain trials shown safe appropriate addition standard care alternative functional testing heart study showed changes diagnoses improves diagnostic certainty changes management leads appropriate use invasive coronary angiography reduces fatal myocardial infarction meta analysis four randomised controlled trials showed leads major reduction myocardial infarction patients stable chest pain summary now established technique assessment coronary artery disease recent test treat randomised controlled trials shown guided changes management improve clinical outcomes
background salt drought tolerant grass family distributed widely arid regions almost information genetics genome close relative wheat stands harsh conditions objectives main aim research isolation characterization salt drought inducible genes differential display amplified fragment length polymorphism method material methods research grown salt drought conditions modifying method several fragments isolated induction studied reverse northern blotting results led improvement non radioactive method many parameters optimized screened approximately transcript derived fragments percent showed varied expression levels response high salt drought treatments relative abundance twenty one selected differentially expressed fragments reverse northern blotting potential applied method sequence comparisons revealed isolated genes involved osmotic adjustment regulation transcription cation transportation stress responses data clearly show modified method successful reliable approach isolation differentially expressed genes
first study assess fungal diversity fungi open cooling tower water systems biofilm water phase production capability fungal isolates also examined mean fungal count different water biofilm samples determined cfu cfu total species identified internal transcribed sequencing common isolated fungi belonged genera aspergillus prevalent fungi aspergillus aspergillus surveyed isolates identified detection opportunistic pathogens allergen species suggests open possible source fungal infection public occupational workers via inhalation skin contact
grows small widely scattered populations wild also popular tree urban areas outside natural range since small native populations several states considered risk cultivated population serve situ repository genetic diversity used restore lost local populations species potential value cultivated conservation depends genetic diversity among cultivated trees compared natural populations using nuclear microsatellite markers genotyped natural populations along trees urban landscapes found even statistics adjusted based population size urban population higher genetic diversity wild populations sampled indicating commercially grown likely mixture genotypes isolated wild populations observed strong genetic differentiation among wild populations evidence least one wild populations
use computer programming spread schools worldwide last century disappeared educational landscape early development visual programming languages scratch movement emerged recent years teachers educational levels different disciplines consider use programming enhances learning many subjects allows students develop important skills systematic literature review presented article aims summarize results recent research using programming scratch subjects related computing communications studies analyzing kind skills students develop learning code environment although analyzed papers provide promising results regarding use programming educational resource review highlights need conduct empirical research classrooms using larger samples students allow obtain clear conclusions types learning enhanced programming
objective gastrointestinal neural system emergence lewy body usually earlier clinical diagnosis parkinson motor symptoms therefore study aimed explore whether gastrointestinal tract prodromal patients patients methods paraffin embedded tissue specimens patients collected second affiliated hospital university tissue specimens non patients undergone surgical resection pathological sections stained immune method positive staining aggregated alpha synuclein alpha phosphorylated alpha synuclein alpha gastrointestinal tract analyze distribution expression alpha prodromal patients diagnosis years years years results according results immunohistochemical staining tissue blocks positively stained respectively total tissue blocks provided prodromal patients positive staining tissue blocks control group tissue blocks collected patients tissue blocks alpha positive staining compared non patients control group alpha positive rate significantly increased pre post diagnosis patients however alpha groups increased significantly also positive expression rate alpha year group lower year year positive rate year group highest conclusions alpha main component lewy body nervous system gastrointestinal track used characteristic predictive marker prevention disease
guidelines treatment atopic dermatitis issued japanese dermatological association basically designed dermatologists first prepared revised guidelines japanese society usa basically designed including dermatologists first prepared revised article review definition pathophysiology etiology epidemiology diagnosis severity classification examination diagnosis severity assessment treatments japan according two guidelines based definition diagnostic criteria patients meeting three basic criteria pruritus typical morphology distribution eczema chronic chronically relapsing course regarded treatment measures basically consist drug therapy skin care elimination factors drugs reduce related inflammation skin topical corticosteroids important accurately reduce inflammation related using topical anti inflammatory drugs proactive therapy refers treatment method inducing remission topical corticosteroid applied skin addition skin care order maintain remission
nonlinearity used enhance broadband rotating piezoelectric vibration energy harvesting construct proper nonlinear rotating challenging problem engineering applications article presents theory based method explore broadband mechanism necessary conditions nonlinear rotating piezoelectric vibration energy harvesting system first perturbed state space representation nonlinear rotating energy harvesting system built based dynamic model seen stability nonlinear system physical basis achieving broadband low frequency rotating energy harvesting second function defined derive two necessary conditions bifurcation chaotic motions simulations performed identify key parameters effects conditions including distance rotating frequency excitations seen bifurcation chaotic motions occur nonlinear rotating energy harvesting systems single frequency broadband excitations finally experiments carried validate two necessary conditions results demonstrate proposed method provide important guidelines optimally designing nonlinear rotating piezoelectric energy practice
revised diagnostic criteria anorexia nervosa eliminating requirement weight psychological criteria adding formal diagnosis atypical individuals psychological symptoms without low weight sought determine whether bone density bmd impaired women diagnosed using new dsm criteria sectional study women dsm dsm dsm dsm criteria dsm atypical atypical healthy comparison group measurements included dual energy ray absorptiometry eating disorder examination questionnaire eating disorder inventory hamilton depression anxiety rating scales score present dsm dsm atypical mean scores low dsm dsm intermediate atypical highest lack prior low weight history overweight obesity protective bone loss mean lean mass percent fat mass significantly lower groups dsm dsm atypical comparable psychopathology diagnostic criteria many women diagnosed atypical using dsm criteria low bmd presence history low weight remain important indications dxa loss lean mass addition fat mass present groups contribute low bmd deleterious effect eating disorders bmd extends beyond current low weight wiley periodicals inc int eat
relations adolescents habitual usage media violence tendency engage aggressive prosocial behavior school setting examined cross sectional study germany completed measures violent media exposure normative acceptance aggression participant ratings prosocial aggressive behavior obtained class teacher media violence exposure unique predictor teacher rated aggression even relevant covariates considered predicted prosocial behavior gender path analyses confirmed direct positive link media violence usage teacher rated aggression girls boys direct negative link prosocial behavior found indirect pathways identified higher aggressive lower prosocial behavior via acceptance aggression normative although significant gender differences media violence exposure aggression prosocial behavior similar path models identified boys girls association professionals services adolescents published elsevier ltd rights reserved
defined one dimensional core constructed employing blocks via facile hydrothermal strategy synergistic interaction large intimate interfacial contact thin core efficiently charge carrier recombination metal free active sites evolution water consequently comparison bare resultant core composite exhibits enhanced visible light activity evolution notably activity optimized exceeds pure composite factor times respectively identical reaction conditions apparent quantum yield reaches work provides simple paradigm facile controlled synthesis shaped based composite photocatalysts towards boosted solar energy conversion elsevier rights reserved
beta essential part enzyme system efficient complete hydrolysis biomass pseudomonas produced lower temperature hence play important role bringing energy requirement production enhance production two statistical tools box designs applied reveal influential factors respective concentration maximum production submerged fermentation optimal medium composition maximum production yeast extract temperature degrees optimized conditions production increased fold large scale production tank resulted higher production within incubation fold higher studies commercial supplemented crude resulted improved sugar release comparatively low temperature degrees therefore showed great potential cold active production used enzyme along commercial improve efficiency international union biochemistry molecular biology inc
brushless doubly fed induction generator one upcoming machines research study used offshore many advantages conventional machines study electric magnetic fields plays vital role design machines electric machines used novel applications around world driven need greater power efficiency transportation aerospace defense industrial automation areas difficult design machine meet performance criteria ansys maxwell software powerful tool analyze relevant performance indices related machine design finite element method used software accurate analysis modeled machine paper design brushless doubly fed induction generator pole configuration pole configuration done analysis configurations carried using ansys maxwell software authors published elsevier ltd
medial opening high tibial surgical procedure treat knee osteoarthritis associated deformity however ideal final alignment hip knee ankle angle frontal plane maximizes procedural success post operative knee function remains controversial therefore purpose study introduce subject specific modeling procedure determining biomechanical effects alignment cartilage stress distribution finite element knee model derived magnetic resonance imaging healthy participant manipulated silico simulate range final angles degrees degrees degrees degrees loading boundary conditions assigned based subject specific kinematic kinetic data gait analysis multiobjective optimization used identify final alignment balanced compressive shear forces medial lateral knee compartments peak stresses decreased medial increased lateral compartment shifted balanced loading occurring angles degrees degrees femoral tibial cartilage respectively concept introduced provides platform non invasive patient specific preoperative planning medial compartment knee osteoarthritis published elsevier ltd rights reserved
voltage features negative differential conductance region current voltage characteristics high quality resonant tunneling diode detected found oscillations considered taking account excitation stimulated tunneling electrons quantum active region resonance quantum layer two barrier layers rearrangements characteristics resonant tunneling diode consequence topological transformation measurement circuit circuit series resistance circuit shunt experimentally studied analyzed revealed substantial changes current voltage characteristics resonant tunneling diode discussed using kirchhoffs voltage law
internet organizational network security still threatened devastating malicious activities given continuous escalation attacks terms frequency paramount importance generate effective cyber threat intelligence aim inferring characterizing mitigating nevertheless imperative tasks partially lack approaches produce prompt accurate intelligence investigating various network traffic sources paper propose evaluate big data architecture rooted real time network traffic processing distributed messaging scalable data storage key benefit proposed architecture aggregation transformations heterogeneous network data allowing greater focus cyber threat intelligence analytics rather data management aggregation empirical evaluations investigating application machine learning analytics exploiting artifacts resulting prototype proposed architecture using real network traffic indeed demonstrate practicality effectiveness added value proposed architecture
since development combined oral contraceptives years ago significant innovations occurred domain progestin evolving knowledge progestin mechanism action physiology allowed development novel limited steroid receptor cross reactivity decreased side effect profiles pharmacokinetics optimized modern delivery systems review summarizes current knowledge progestin physiology modern delivery systems developments progestin agonists antagonists contraception
physical activity sports participation promoted counteract increased prevalence overweight obesity children young adults high body mass index physical activity level associated increased risk sports injuries objective determine relationship sports injuries overweight sports participants years taking physical activity account data obtained injuries physical activity netherlands survey analyses based representative sample sports participants years univariate multiple logistic regression analyses applied investigate association sports injury weight status sports participants overweight compared normal weight sports participants odds sustaining sports injury confidence interval overweight sports participants odds sports participants evidence overweight sports participants years increased injury risk compared normal weight sports participants even level physical activity taken account additional research recommended regarding overweight people start participate physically active lifestyle
paper coded optical code division multiple access system using hybrid modulation scheme investigated idea propose effective approach simultaneous improvement system capacity security data formats non return zero differential phase shift shift used get orthogonal modulated signal observed proposed hybrid modulation provides efficient utilisation bandwidth increases data capacity enhances data confidentiality existing systems proposed system performance compared current state art schemes elsevier inc rights reserved
future patients active role strengthening maintaining health motivate patients giving chance stay homes instead going hospital system deployed patients home hence influence everyday live therefore believe system adapt behavior burden patient resident use aim extended existing platform reason activities daily living smart home scenario extensions tested three datasets extensions two algorithms one understanding residents everyday habits one predicting residents next activity prediction algorithm correctly predicts datasets
higher kinematic pair converts rotary motion helical motion presented alternative screw joint lower kinematic pair first existence rolling transmission pair rotary helical motion conversion proven corresponding pair rolling surfaces pitch surfaces relative position defined set kinematic transmission parameters presented method gear tooth forming pitch surfaces using boolean operations computer aided design cad program proposed finally applying methodology pair rotary helical transmission obtained using prototype presents negligible high continuous without interference equation simple generating surface also provided
object tracking studied problem computer vision many practical applications problem difficulty depend upon several factors knowledge target object quantity type parameters tracked although success building specific object classes human face mice etc tracking generic objects remained challenging issue object drastically change appearance rotating plane illumination scene changes especially videos clear original form video requires enhancement quality improved proposed work different algorithms carried detect generic objects non rigid objects objects occlusion environment images contain sort objects also images contains numerous objects improve tracking efficiency objects non rigid changing nature also predicted perfect manner computational complexity reduced reliability accuracy efficiency improved
detection fungal elements characterization patient specimens provides fundamental information histological sections fungi frequently seen skin mucosal surfaces arteries veins surgical specimen immunocompromised patients tissues obtained microbial culture continues central method diagnosing fungal infection complemented using specific capable identifying previously fungal infections evaluating tissue invasion employ reagents create binding sites glycol groups fungal cell walls either reagent silver ions silver periodic acid modifications commonly used tissue sections specimens
increasing popularity dynamic voltage frequency scaling schemes portable low power applications demands highly efficient chip converters primary aim work enable increased efficiency chip conversion near threshold operation multi core architectures main idea supply nominal high chip voltage multi core processor cores voltage stacked generate near threshold low voltage based kirchhoffs voltage law charge recycling however implicit conversion affected current imbalance cores push pull switched capacitor regulator designed keep mid voltage close near threshold value half stacked voltage domain self regulation capability combined push pull based switch capacitor regulator shown average efficiency conversion workload imbalance varying load
flash based frequently used space applications now common designs include small microcontroller paper present results detailed study two implementations arm cortex processor first implementation uses standard design flow second implementation protected techniques including designs tested using heavy ion micro beam using methodology enables individual ions localized space time rate silent data reduced protected version many error scenarios reproduced using simulation based fault injection overall results suggest contribution single event transients sets neglected results show limitations based
paper explores interest policy makers encourage develop green economy particular focus government attempts shift mainstream building construction sector towards adopting green building methods techniques building sector focus shift towards ways working building due high contribution greenhouse gas emissions associated concerns enhanced global warming climate change paper outlines recent development national policy green building exemplified legislation code sustainable homes building regulations given rise particular set responses green building requirements favour technological solutions readily existing system developments draw upon socio technical sustainability transitions research one strand focused ways niche developments challenge disrupt existing regimes practice empirically research green building sector involved depth interviews range actors green building sector including architects building companies materials policy makers respondents within green building niche critical current legislation argue narrow fails adequately encourage consider green building forms contribute substantial reductions carbon emissions respect locally appropriate building methods elsevier ltd rights reserved
oxidase uric acid human metabolism uric acid lead finally cause diseases one major components green inhibitory activity interaction mechanism evaluated methods coupled molecular simulation found inhibited competitive manner inhibition constant value mol bind single binding site binding driven mainly hydrophobic interactions analysis synchronous fluorescence circular spectra demonstrated microenvironment secondary structure altered upon interaction molecular docking results revealed actually interacted primary amino acid residues located within active site pocket elsevier ltd rights reserved
paper phase shift presented performs phase frequency synchronization analog domain presented utilized short range ultra wideband wireless communication scenarios greatly simplify wireless system demands digital signal processors implemented low cost system package module including narrow bandwidth filter substrate analog carrier recovery synchronization experimentally characterized using custom designed modules test signal generation furthermore shown presented carrier recovery concept exhibits efficient phase noise suppression results demonstrate successful coherent data rate high dynamic range robustness undesired phase frequency fluctuations
development field software allows researchers implement control law miniaturized devices field programmable gate arrays fpga microcontroller control laws used industrial applications key work design implementation fixed low order controller microcontroller order control electronic system main objective controller ensure time response performances settling time overshoot controller parameters obtained resolving non convex optimization problem considering desired closed loop specifications use classical optimization method resolve kind problems lead local solution obtained solution optimal therefore suggested apply global optimization method order get optimal control law ensure specified time response performances proposed method work generalized geometric programming method method consists transforming mathematical transformations non convex optimization problem convex one implementation proportional integral controller proportional integral pid fixed low order controller real electronic system shows efficiency latter one
paper concerned sampled data leader following consensus group agents nonlinear characteristic distributed consensus protocol probabilistic sampling two sampling periods proposed first general consensus criterion derived systems directed graph number results several special cases without delays deterministic sampling obtained second dimension reduced condition obtained systems graph shown leader following consensus problem stochastic sampling transferred master synchronization problem one master system two systems problem solving independent number agents greatly facilitates application large scale networked agents third network design issue addressed demonstrating positive active roles network structure reaching consensus finally two examples given verify theoretical results
recent years technological advancements led data distinctive domains need development solutions based parallel distributed computing still long way research development massive computing frameworks continuously growing particular stage highlighting potential research area along key insights asset researchers field therefore paper explores one emerging distributed computing frameworks apache top level project apache software foundation based bulk synchronous parallel model present unbiased critical session apache conclude research directions order assist interested researchers
geotextiles thin polymeric materials widely used geotechnical environmental hydraulic applications employed infiltration basins designed collect improve quality storm runoff waters infiltration surrounding soil introduction geotextiles infiltration basins significantly influence flow transfer pollutants present storm runoff waters solute form associated particulate phases objective work study influence nonwoven geotextile conservative solute transport sandy gravel porous media saturated unsaturated conditions solute transport columns containing soil geotextile characterized tracer solution suspension particles constant flow rate saturated unsaturated conditions flow pattern described using model implemented code results showed nonwoven geotextiles increase flow homogeneity effect flow depended soil heterogeneity degree water saturation retention efficiency column scale also modified presence geotextiles flow increased filter capacity soil thereby decreasing pollutant transfer form elsevier ltd rights reserved
alcohol exposure pregnancy cause adverse effects fetus fetal development leading later physical mental impairment common clinical tool determine fetal alcohol exposure maternal self reporting however objective useful method based use biomarkers biological specimens alone combination maternal self reporting review reports clinically relevant biomarkers detection prenatal alcohol exposure systematic search performed ensure proper overview existing literature studies selected give overview clinically relevant neonatal maternal biomarkers direct biomarkers fatty acid ethyl esters ethyl ethyl sulfate found appropriate biomarkers relation detection review biomarker clinical context compared advantages disadvantages biomarker relation window ease collection ease cost analysis biomarker biomarkers found applicable detection even low levels alcohol exposure accessible matrix determination blood accessible matrix determination
multiple technique proven useful tool missing data analysis propose markov chain monte carlo method conduct multiple incomplete correlated ordinal data using multivariate model conduct thorough simulation study compare performance proposed method two available methods multivariate normal based chain equation methods various missing data scenarios illustration present application using data smoking cessation treatment study low income community corrections smokers
given lack active nurses countries throughout world combination demographic changes utmost importance protect nurses prevent psychological distress strong association premature occupational leave aim study investigate effects quality leadership social support work psychological distress nurses determine whether nurses mediates relationship determinants outcomes cross sectional survey design used gather data study utilized part database nurses early exit study total nurses covering nurse working hospitals nursing homes home care institutions european countries filled questionnaire response rate model variables job satisfaction satisfaction positive personal burnout negative quality leadership social support immediate social support near colleagues sound valid reliable measures used outcomes testing structural equation mediation model indicated respectively positive negative influences leadership quality social support colleagues nurses wellbeing psychological distress partially mediated reduced nurses social work environment highly important relation nurses psychological distress
effective emotionally parenting practices constitute salient protective factors lives children youth although social workers influenced important ways scholarship associated development dissemination culturally relevant evidence based parenting interventions populations low income ethnic minorities continue lack access culturally relevant efficacious parenting interventions united states due widespread mental health disparities addressing gap service delivery necessary particularly populations exposed historical intense contextual adversity increased risk engaging harsh parenting practices purpose paper reflect process change documented group latino immigrant parents exposed culturally adapted evidence based parenting intervention emphasis describing process change leading improved outcomes relevant clinical social workers engaged direct delivery preventative clinical parenting interventions thus manuscript focus issues engagement retention parents important consideration importance integrating evidence based knowledge cultural relevance key principles social work practice
paper free deformation method proposed speedup modeling electric motor optimal design process proposed method neither mesh regeneration increase number required defining boundary mesh fine computational mesh refined meshes quickly derived using coordinate mapping technique calculation time therefore greatly reduced geometric parameters changed according optimal design time mesh quality guaranteed ensure accurate requirement finite element method numerical examples problems problems reported demonstrate efficiency effectiveness proposed method
purpose aim study compare differences current orthopaedic trauma training programs across europe methods questionnaire sent federation orthopaedic europe representatives different european countries responded questionnaire included demographic information information concerning structure training programs including duration selection mandatory training requirements results number per specialist varied countries ratio generally five six years countries half countries selection interview based nearly countries utilized participating countries final examination assessing components training found one country united kingdom mandatory minimum requirements courses surgical procedures research leadership nearly participating countries one none four components mandatory training requirement conclusions many similarities training programs important differences remain overall requirements final main limitation study unable get data european countries continue serve sharing best practices ultimate goal improving level orthopaedic training across europe future studies aim include details training programs include data countries
fruits spice also highly valued therapeutic agent many including asthma cold respiratory problems herein investigated structural features vivo activity three fractions isolated fruits water extract upon yielded two fractions soluble fraction one existence type side chains kda revealed moreover providing fine structural details side chains generated characterized parental water extract contained oral administration body weight guinea pigs showed activity comparable phosphate body weight fraction containing showed comparatively higher activity soluble fraction contained lower parental water extract significantly specific airway smooth muscle reactivity three fractions remained unchanged finally combination parental extract synergistically enhances effect guinea pigs elsevier rights reserved
paper focuses effectiveness passive adaptation measures climate change medium long term three case studies located central italy order identify highlight passive measures provide comfort conditions lowest net heating cooling energy demand input assumptions consider constant thermal comfort level take account either effect systems performance degradation materials ageing study results show case poorly buildings medium term reduction energy needed heating bigger increase cooling resulting total annual net energy need decrease long term opposite happens conversely considering high level thermal insulation due large increase cooling demand total annual energy need rises periods furthermore attention paid internal loads solar gains due projected climate change become main contributors energy balance general since magnitude energy need increase cooling decrease heating significant long term varies function type building passive measure adopted level thermal insulation research results lead pay close attention different types energy interventions selected function effectiveness time
harvested rainwater alternative water source buildings especially non potable uses irrigation toilet flushing rainwater harvesting perceived sustainable design approach limited information environmental economic performance technology address literature gap life cycle assessment life cycle tools applied potentially use harvested rainwater five scenarios modeled including new versus building irrigation versus toilet flushing water end use rainwater scenarios sized using yield approach long term daily precipitation energy greenhouse gas emissions calculated using economic input output life cycle assessment construction phase energy use pump water wastewater treatment databases life cycle environmental impacts costs estimated compared business usual scenario water supply demands met supplied potable water combined separate network discovered energy greenhouse gas emission payback periods achieved almost every scenario yet cost payback periods implementing harvested rainwater found longer life time building except two scenarios using rainwater irrigation project using rainwater toilet flushing new construction project two scenarios lowest cost energy greenhouse gas emission impacts among scenarios modeled reducing occupancy match toilet flushing demand increased per person impact however general per person impacts much lower persons impact driving electricity use separate stormwater runoff water bodies thereby prevent environmental problems resulting combined rainwater harvesting system connected separate found reduce energy greenhouse gas emissions less rainwater harvesting system connected combined elsevier ltd rights reserved
nano micro scales resistance particle rolling critical factor many applications biological phenomena affects particle adhesion motion flow particle manipulation placing present work non contact non invasive experimental method detailed applied determine pre rolling critical angle single transient surface acoustic waves saw utilized excitation mechanism image processing detection monitoring analysis techniques capturing micro nano scale dynamics values set diameter glass substrate reported studied particles determined degrees also observed saw field burst cycle change rolling sliding directions speeds accelerations trajectory particle often found non linear nonlinear behavior attributed surface properties particles substrate possible electric charge density chemistry variations potential contamination surfaces moreover effect electric charge developed due effect particle motion investigated found percentage particles function amplitude excitation field also function possible electrostatic charges developed particles due motion substrate addition potential uses particle manipulation removal adhesion characterization reported results utilized numerical simulations motion deposition elsevier rights reserved
malaria parasite related organisms possess known protein synthesis validated drug target malaria antibiotics inhibit translation also inhibit protein synthesis sometimes used malaria prophylaxis treatment identified components indirect pathway biosynthesis hypothesized essential protein synthesis report characterization first enzyme pathway expressed recombinant enzyme escherichia coli showed determined kinetic parameters demonstrated inhibition known bacterial inhibitor also localized blood stage parasites gene data show biosynthesis proceeds via essential indirect pathway bacteria
objectives describe effectively provided adequate prenatal care postpartum contraception prevent repeat unintended pregnancies women using medication maintenance therapy pregnancy methods conducted retrospective chart review women using pregnancies receiving prenatal care regional high risk care clinic july june examined prenatal care usage birth outcomes postpartum contraception using chi binary logistic regression modeling results patients white used used prescribed illicit fewer half received documented prenatal counseling postpartum contraception sixteen premature sixty four infants diagnosed neonatal abstinence syndrome women attended postpartum visits overall women received postpartum contraception significant predictors postpartum contraception use preterm birth postpartum attendance conclusions alternative strategies providing postpartum care explored women using pregnancy significantly likely use postpartum contraception attend postpartum
plants low temperatures activate cold response pathway playing prominent role cold triggering set cold related gene expressions homologous gene designated cold tolerant identified carries sequences nuclear localization signal dna binding domains acidic activation present plant proteins southern analysis indicated presence three gene genome one amino acid variation protein cold tolerant sensitive putative promoter regions differential regions found northern blotting pcr analysis found reached highest expression cold treatment homologous gene downstream gene expressed plant stem cold tolerant without cold treatment without cold treatment gene activated cold sensitive cold treatment prompt expression levels homologous genes transgenic arabidopsis overexpression promoter resulted like plants later greater tolerance
background studies evaluated impact pre treatment drug resistance response combination antiretroviral treatment children objective joint chain project assess prevalence mutations association virological outcome first year children methods hiv infected copies months assessed cox proportional hazards models models adjusted baseline demographic clinical immunology characteristics period start initial regimen results children vertically infected initiation median interquartile range age years cell count cells hiv rna log copies children confidence interval harboring virus mutations children virus resistant prescribed drugs overall cumulative kaplan meier estimate virological failure cumulative risk tended higher among children harboring virus resistant drug prescribed among receiving fully active versus multivariable analysis age associated higher risk reduced risk per additional year conclusions significantly associated higher risk children first year risk decreased per additional year treatment initiation due mutations time lack appropriate formulations particular younger age group important determinant virological failure
low solar energy harvesting conversion efficiency become major problem solar energy science engineering owing difficulty capturing solar energy across wide solar spectrum especially visible light range inspired extraordinary properties materials arising decreased dimensions study explore system formed two dimensional monolayer semiconductor engineering visible light absorption system via either bond coupling mechanism forms ideal type band alignment stronger donor acceptor coupling contact system efficiently coupled geometry helps couple electrons therefore leading enhancement absorption peaks visible frequency range changing element red shift visible light absorption peaks accompanied stimulating optical response whole system observed comprising low dimensional monolayer systems promote charge separation optical absorption visible range arise effects adsorbent nature decreasing size efficient interfacial coupling mechanism therefore promising photovoltaic photocatalytic materials
objective study investigate whether potentially inappropriate medication use predictor mortality community based population older adults cohort study performed january december based data representative sample population aged years older living brazil univariate multivariate analyses association variable interest use pharmacological groups mortality based extended cox model proportional hazards extended model adopted include measurement exposure interest throughout follow period baseline adjustment variables included sociodemographic characteristics health status use health care services medications level significance adopted analyses prevalence use multiple adjustments risk death among users least one higher among use among groups analyzed antipsychotics strongly associated mortality study revealed high prevalence use among community based aged population also identified use predictor mortality group individuals indicates need selection safer drug therapy alternatives patient group
absence steroid receptors known mechanism gene regulation steroid hormones candida albicans genome wide analysis albicans cells treated progesterone using cdna microarrays find complete repertoire steroid responsive genes northern blotting analysis employed validate genes differentially regulated progesterone microarray experiments total genes found significantly regulated progesterone among regulated regulated observed progesterone considerably enhanced expression multi drug resistance genes belonging atp binding cassette super family multidrug transporters suggesting possible relationship steroid stress genes several genes associated induction establishment pathogenesis also found regulated silico search various transcription factor binding sites promoter affected genes revealed regulated genes responsive progesterone stress responsive elements also found promoters several responsive genes data sheds new light regulation gene expression albicans human steroids correlation drug resistance virulence morphogenesis general stress response comparison drug induced stress response also discussed
previous research animals indicates flavonoid compounds immunomodulatory properties however human research remains inconclusive aim systematic review assess efficacy dietary flavonoids upper respiratory tract infections immune function healthy adults created search strategy run cochrane central register controlled trials medline embase embase classic cinahl returned studies initially screened reviewers independently assessed remaining studies eligibility criteria fourteen studies initially identified included review primary outcome measure effect flavonoids incidence duration severity included studies flavonoid supplementation ranged overall flavonoid supplementation decreased incidence compared control apparent adverse effects sick day count decreased flavonoid supplementation although unclear differences bio immune markers interleukin tumor necrosis factor alpha interferon gamma neutrophils trivial intervention control groups intervention exercise exercise included findings suggest flavonoids viable supplement decrease incidence otherwise healthy population
developed new model simulate supplemental irrigation hydro economic potential rainwater harvesting system agricultural areas using model soil moisture crop land supplemental irrigation requirements rainwater storage farm reservoir system surface ground water availability predicted irrigated system used harvest rainwater rainy season stored water applied supplemental irrigation economic analysis performed calculate benefits due irrigation system gains increased crop yield downstream water availability irrigated system compared system addition calculated impacts dry wet seasons total value gains grain water gains irrigated conditions performed sensitivity analysis quantify impacts model input parameters total value gains analyses showed system produce crop yields three times greater agriculture water stress season total water use irrigated system greater system water use efficiency irrigated system higher system dry season total value gains due increased crop yield supplemental irrigation downstream water availability irrigated system greater system wet season total value gain irrigated system greater system precipitation scenario analysis wet dry seasons indicated benefits rainwater harvesting system considerably greater dry seasons wet seasons
important disease related proteins play critical roles plant defense disease investigate function resistance infection gene encoding cloned used measure expression levels infected results showed comparing control group time expression levels reaching peak delayed expression levels maintained significantly high level longer time results suggest contribute defense fungal infection
maze extension object specification language supporting specification development multi agent systems mas following recommendations agent oriented software engineering community supports three distinct levels abstraction macro level systems overall global behaviour independently agents system operate interact level agent interactions iii micro level operation individual agents object high level support component based specification suited modelling mas complemented maze support action refinement facilitate top development process macro micro level number aimed specifying low level mechanisms required dealing asynchronous communication timing constraints micro level latter existing object require object semantics paper provide overview maze illustrate use non trivial case study swarm robotic algorithm self assembly elsevier rights reserved
objectives circadian regulation human physiology behavior body temperature sleep timing depends light hour day study investigated effect changing light temperature workplace sleep wake activity rest behavior methods experimental group experienced light change compared non intervention group remained environment throughout week study period january february sleep logs continuously assessed sleep wake behavior activity patterns results study period timing sleep activity free days steadily advanced parallel seasonal progression non intervention group contrast temporal pattern sleep activity experimental group remained associated constant onset work conclusion results suggest artificial blue enriched light natural light subjects working light appear natural subjects exposed blue enriched light appear office hours results confirm light dominant human clock efficacy depends spectral composition results also indicate blue enriched artificial light potent used
ever growing demand location independent access autonomous decentralized systems ads anomaly detection scheme industrial highly satisfied demanding real time reliable industrial applications becomes one pressing subjects ads paper present innovative approach build traffic model based structural time series model chemical industry system basic structural model time series four items established stationary analysis industrial traffic parameters model identified state space model conducted training sequence using standard kalman filter algorithm furthermore performance state space model evaluated experimental results confirm significant improvement detection accuracy validity abnormal data localization elsevier rights reserved
article design implementation innovative photovoltaic system prototype intelligent control lighting based arduino described lighting system connected power generation system composed isolated photovoltaic cells lighting control system subject vehicle detection variation light intensity vehicles circulating highway variation light intensity control lighting system managed arduino microcontroller turn information distributed along highway thus expected lighting system present significant savings energy consumption making use innovative technologies
optical linear array reconfigurable bus system optical parallel computing model consists optical optical processing elements previous work following designs models considered mostly connected linear array processing elements specific order results communication memory bound architecture imposes algorithm scheduling difficulties potentially limit capability model highly scalable flexible designed high bandwidth high speed developed paper matrix multiplication algorithm designed take advantage new interconnection design includes comparison previous algorithm advantages include addressing communication limitations enabling flexible algorithms increased processing efficiency
paper describes system converting methanol pure hydrogen system based reactor operating elevated pressures followed membrane based hydrogen separation high pressure membrane stream expanded turbine generating additional power process simulation illustrates effects system operating parameters performance demonstrates system efficiency similar coupled fuel cell electrical generator overall fuel electricity efficiency depending upon efficiency fuel cell stack elsevier rights reserved
soybean research work india intended towards yield improvement biotic stress management food grade characteristics resulted varieties maximum yield potential increase resistant tolerant insects moisture stress higher nutritional characteristics yield index yield soybean increased since commercial cultivation technology achievement index increased per value crops output constant prices increased per cent districts higher proportion gross area soybean also per value output higher major soybean growing districts districts though present varieties exist seed chain however four varieties dominate seed chain account per cent total soybean seed requirement country per cent seed availability bridge increase demand oil nutritional requirements genetic improvement soybean attenuating major issues required
importance insect primary protective barrier long noted present study addressed issue utilizing experimental infection system composed model two fungal species relatively susceptible fungi natural route infection developed age adults exhibited much higher whereas exhibited seemingly higher compared natural infection employed direct inoculation cultured body cells found highly equally virulent fungal species results collectively suggest important role antifungal host defense subsequently conducted knockdown synthase gene targeted mid peaks expression respectively using injection low dosages avoid resulting looked normal adults showed mild phenotype gene knockdown compromised significantly host defense fungal infection via natural route except configuration knockdown suggesting indispensable role elsevier inc rights reserved
three degrees freedom dof coupled numerical simulation technique extracting aerodynamic derivatives bridge proposed evaluated study computations performed finite volume unstructured computational flow dynamics cfd solver using two dimensional hybrid meshes fine near wall resolution accuracy numerical model verified identifying aerodynamic derivatives one thin plate section theoretical solutions two typical deck sections two long span bridges extracted aerodynamic derivatives coupled techniques compared results showed good agreement experimental results proposed dof coupled method provide almost level accuracy dof method computation time appropriateness linear superposition theorem aeroelastic forces generated different motions single coupled mode examined found significant differences aeroelastic forces various high order aeroelastic force components successfully captured newly presented coupled numerical simulation aerodynamic derivatives proved immune high order components mathematically knowledge essential thorough evaluation aerodynamic derivatives identification accuracy proposed technique analytical viewpoints presented paper serve building block developing new numerical tools analytical frameworks rapid accurate evaluation aerodynamic derivatives response long span flexible bridges wind excitation american society civil engineers
objective sedentary behaviour unclear conducted systematic review investigate associations various biomarkers older adults methods electronic databases searched medline embase cinahl july identify studies objective subjective measures sample size mean age years accelerometer wear time days methodological quality tool protocol pre specified results abstracts retrieved full text articles explored excluded final sample articles total biomarkers detected investigated markers body mass index bmi waist circumference blood pressure triglycerides high density lipoprotein hdl inflammation markers identified interleukin reactive protein tumor necrosis factor alpha lack renal muscle bone biomarkers randomized controlled trials found positive correlation bmi neck circumference fat mass cholesterol insulin levels cohort studies additionally leptin peptide low density lipoprotein negative correlation hdl conclusion studied biomarkers associated cardiovascular metabolic origin suggestion negative impact biomarkers still paucity high quality investigations exist longitudinal studies objectively measured needed elucidate pathophysiological pathways possible associations unexplored biomarkers authors published elsevier
group focused moral foundations moral values help protect groups welfare sharply divide non however little evidence drives divide moral foundations theory model motivated social cognition associate group focused moral foundations differences conflict detection resolution capacity opposing directions individual differences conflict detection resolution specific differences examining thus objective non biased opportunity contrast influential theories report increased adherence group focused moral foundations strongly associated whole brain corrected reduced gray matter volume key regions conflict detection resolution system anterior cingulate cortex lateral prefrontal cortex reduced gray matter reliably associated reduced neural cognitive capacity findings support idea outlined model motivated social cognition belief group focused moral values associated reduced conflict detection resolution capacity elsevier rights reserved
permanent birth control system inc san currently food drug administration approved sterilization method widely accepted safe effective procedure present rare case coil fragmentation distal migration small large bowel days insertion device describe successful management complication using intraoperative providers using aware possibility fragmentation coils intraoperative imaging ideally strongly considered management migration ensure localization full retrieval material rights reserved
multi potential stem cells create walls terminal cells localized membrane tightly endothelium frequently mentioned molecular markers include neural glial antigen beta type platelet derived growth factor receptor beta smooth muscle alpha actin alpha sma regulator protein signalling adhesion protein different functions physiological processes assigned maintaining integrity senescence endothelial cells regulation vascular tone potential differentiate cells probably also involved pathological processes tissues fibrosis review focus participation process blood vessel formation regeneration skeletal muscle tissue fibrosis strong evidence participation endothelial homeostasis pathological conditions fibrosis reveals broad potential therapeutic use cells targeted pharmacological modulation leading blocking signalling pathways responsible differentiation seems promising strategy treatment fibrosis early stages
development country malaysia facing challenge develop economic others economic changing agriculture manufacturing drastic change need people also adapt situation now days changing become issues changing work life agriculture manufacturing changing technologies changing people thinking etc previous studies found major issues majority graduate enough skills day day issues keep challenges government also students institutions previous study found alternative overcome changing delivery applied applied subjects taken applied mathematics students facing problem applied mathematics students subjects attractive using alternative methodologies facing now day future issues research study effectiveness alternative tool enhancing skills among graduates study adopts combination qualitative quantitative approaches data collected using documents analysis students sample quasi experimental study comprise manufacturing engineering undergraduates several public institutions higher learning malaysia result shows student enhanced skills furthermore student competitive become relevance industries need skills shown applied mathematics helping also valuable become major function catalyst skills elsevier ltd rights reserved
long term abuse affect urinary system resulting lower urinary tract symptoms luts pathogenesis still unknown previous studies demonstrated change expression brain derived neurotrophic factor bdnf serum abuse patients aim present study explore mechanism mediated bdnf signaling pathway bladder rats chronic treatment rats randomly assigned control normal saline group five rats group experimental group given via intraperitoneal injection daily control group treated saline weeks treatment samples control group examined transmission electron microscopy tem non purification histopathology immunohistochemistry western blot carried groups histological study showed epithelium inflammatory cell infiltration treated rat tem showed chronic treatment results structural damage organelles immunohistochemical staining western blot showed expression bdnf significantly lower group however expression phosphorylated extracellular signal regulated kinases group higher whereas total similar control group long term abuse reduces expression bdnf inducing phosphorylation bladder wall play important role pathogenesis associated luts
paper presents vivo performances resource optimized digital action potential detector featuring adaptive threshold based new sigma delta control loop proposed detector optimized utilizing low hardware resources makes suitable real time implementation common low power microcontroller units adaptive threshold calculated using digital control loop based sigma delta modulator precisely estimates standard deviation neuronal signal amplitude detector demonstrated using common family incorporated small wireless platform combined neural recording system fully characterized experimentally within vivo experiments freely moving transgenic mouse expressing results demonstrate proposed detector used achieve overall data reduction ratios transmitting detected comparison obtained results approaches shows proposed detector provides similar performances significantly resource demanding approaches
floods natural disasters cause economic damage global level therefore flood monitoring damage estimation important population authorities insurance companies paper proposes original solution based hybrid network complex image processing problem first novelty multilevel system two components terrestrial aerial proposed designed authors support image acquisition region terrestrial component contains ground control station distance via internet ground data terminals fixed nodes network data acquisition communication aerial component contains mobile wing type order evaluate flood damage two tasks accomplished network area coverage image processing second novelty paper consists texture analysis deep neural network taking account new criteria feature selection patch classification color spatial information extracted occurrence matrix mass fractal dimension used finally experimental results real mission demonstrate validity proposed methodologies performances algorithms
autism spectrum disorder asd neurodevelopmental disorder atypical cortical maturation leading deficiency social cognition language numerous studies attempted classify asd using brain measurements cortical thickness surface area volume promising results however sample sizes studies limit external validity generalizability population level large scale collaborations enhancing neuroimaging genetics meta analysis autism brain imaging data exchange aim bring together like scientists improve investigations brain disorders best knowledge study represents largest classification analysis detection asd healthy age sex matched controls using cortical thickness brain intracranial volume normalized surface area subcortical volumes able increase classification accuracy overall females novel findings using evolving improve underscore importance large scale data driven approaches collaborations discovery brain disorders
present work energy conservation properties particle hydrodynamics investigated presence fluid solid interactions similarly fluid phase solid bodies modeled solid particles whole solid fluid domain described unique particle system pressure velocity fields extended solid particles different ways taking account consistency issues related differential operators using projection navier stokes equations solid boundary shown solid particles considered energy equation particle system contains extra terms depend pressure velocity field extensions presence extra terms affect consistency model since tend spatial resolution increased three prototypical numerical test cases considered order provide quantitative perspective matter confirm theoretical developments paper test cases show nature terms globally thus accordance second law thermodynamics particular viscous extra term displays remarkably slow rate convergence relevant outcome practitioners deal types flows elsevier rights reserved
patient long becoming subject medical first simply suffering visited kingdom relieve illness one begin understanding story
herein rod like zno nanostructures synthesized via novel hydrothermal route using new set starting reagents synthesized products characterized techniques including xrd eds sem xps ftir prepared zno nanostructures utilized film effect precursor type morphology thickness zno number electrophoresis cycle solar cells efficiency studied results showed crucial effect morphology synthesized zno nanostructures using zno nanostructures leads increase efficiency compared bare similar improvement moreover highest amount solar cell efficiency obtained using zno two cycle electrophoresis deposition
study aimed determine relationship noninvasive measures arterial health estimated year cardiovascular risk measures disease activity time established rheumatoid arthritis fifty rheumatoid arthritis patients underwent noninvasive arterial health testing artery reactivity aortic augmentation index pulse wave velocity carotid artery media thickness carotid artery plaque presence assessment clinical disease activity joint counts clinical disease activity index health assessment questionnaire clinical measures years study visit averaged arterial health testing compared american heart association american college cardiology acc pooled cohort equation spearman methods identified correlations disease activity measures cardiac biomarkers arterial health parameters among patients mean age years disease activity moderate mean study visit corrected aortic augmentation index correlated correlated time averaged joint count joint count patient global assessment physician global assessment pain score acc low risk group year risk highest prevalence carotid plaques arterial health testing identify increased risk cardiovascular disease compared risk obtained acc pooled cohort equation measures arterial stiffness correlate burden disease activity time
powder modified hydrothermal treating mixed characterized scanning electron microscopy sem transmission electron microscopy tem vis spectrometry ray diffraction xrd ray photoelectron spectrometry xps treated powder shown strong organic dye methylene blue xrd xps results demonstrated existence crystals main reason improved charge transfer cause obvious polarization interface two materials considered source remarkable enhancement large amount absorption surface modified used functional material good area gas sensing dye sensitized solar cells photocatalysts
background dysregulation prostaglandin signaling pathway implicated interstitial pneumonia pathogenesis due unstable nature available detection methods precisely reflect levels explored clinical usefulness measuring stable prostaglandin major urinary metabolite respect pathogenesis extent chronic including idiopathic pulmonary fibrosis ipf reflective systemic production methods measured controls patients lung diseases bronchial asthma chronic obstructive pulmonary disease copd extent lung fibrosis assessed score computed tomography immunohistochemical evaluation cox performed find producing cells ipf human bronchial epithelial cells lung fibroblasts used vitro experiments results compared control levels significantly elevated levels positively correlated inversely correlated cox highly expressed epithelial cells ipf lower expression receptor demonstrated derived ipf tgf beta induced cox expression conclusions elevated promising biomarker reflecting disease activity epithelial cells source elevated ipf elsevier ltd rights reserved
distributed generation brought new challenges protection engineers since standard relay settings traditional system longer function correctly new conditions extreme case coordination loss primary directional relay implemented protection device electrical network also suffers performance degradation presence therefore paper proposes mitigation impact coordination employing adaptive protection scheme using differential evolution algorithm impacts prior application presented new mitigation scheme proposed
purpose work formulate solid lipid nanoparticle dispersion exploit efficacy orally prepared melt method formula optimized application factorial design dispersion evaluated particle size efficiency zeta potential optimized batch average size efficiency zeta potential characterized differential scanning calorimetry dsc ray diffraction revealed amorphous nature prepared administered orally induced rats vivo study using diffusion cell indicate gel formulation skin pharmacodynamic study result indicates topical oral evoked significant response compared orally administered suspension results elisa show significant reduction tnf treated rat reason behind action
background purpose national diabetes education program created steps manage diabetes life steps help patients diabetes learn self management care recommendations purpose study explore impact steps participants diabetes management knowledge self efficacy reduction approaches diabetes comparative effectiveness study grade methods sample adults type diabetes enrolled grade included analysis participants took pretest sent home steps took posttest next visit wilcoxon signed rank test used detect differences knowledge self efficacy scale scores pre posttest conclusions analyses revealed increases participants diabetes management knowledge self efficacy pre posttest participants reported formal previous diabetes education showed statistically significant increase knowledge scores compared previous diabetes education implications practice appropriate relevant diabetes education materials improve self management knowledge self efficacy among adults type diabetes providers feel confident using steps resource clinical practice
background schizophrenia patients respond treatment represent debilitating type schizophrenia unmet needs novel interventions date validated animal model refractory schizophrenia methods used poor performance social preference test mice exposed sub chronic correlate negative signs schizophrenia subsequently mice treated according defined responding ratio non responsive generation responding mice produce next generation unfortunately non responsive mice failed thus excluded analyses forward genetic paradigm used produce next generation responding mice assessed brain acid protein levels gaba marker generations results already generation male mice females possible discriminate responders non responders rate responders within consecutive generation increased increase pronounced females regulation levels detected male mice females conclusions preliminary proof concept study producing trans generation enrichment responsiveness trait hypo glutamatergic animal model negative signs schizophrenia model serve platform better characterize responsiveness trait offer model responsive schizophrenia elsevier rights reserved
skin prick testing combination clinical history patient one important step diagnosis ige mediated occupational allergies however skin test performance related quality allergen extracts present consensus document prepared task force consisting expert panel occupational physicians germany italy spain france poland members panel also involved data collection within european multicentre study standard diagnosis occupational allergy aim task force assessment quality commercially available solutions selected occupational allergens standardized procedure conditions different european centers institutes occupational medicine data evaluation shows wide variability among solutions also indicated sensitivity several solutions low therefore improvement standardization solutions occupational allergens highly recommended clinical practitioners also solutions fully reliable main objective document issue consensus suggestions use occupational allergens based european multicenter study existing scientific evidence expertise panel
pneumonia refers lung inflammation caused different pathogens factors common pediatric disease occurring infants young children closely related anatomical physiological characteristics infants young children frequent winter spring sudden changes temperature pneumonia serious disease poses threat childrens health morbidity mortality rank first accounting pediatric inpatients due juvenile age severe illness rapid changes children often suffer acute heart failure respiratory failure even toxic time different stages process emergency treatment tends relapse directly places lives children risk severe pneumonia constitutes one main causes infant mortality process nursing children severe pneumonia intensive care provided including condition assessment diagnosis close observation disease keeping airway rational oxygen therapy prevention treatment respiratory failure support vital organs complications health education inflammatory response controlled prevent reduce mortality summary positive effective nursing promote rehabilitation children patients reinforced adequate communication parents
long known many short chain carbohydrates induce abdominal symptoms similar patients irritable bowel syndrome ibs hypothesized restricting intake short chain carbohydrates either slowly absorbed digested small intestine considered together similar effects intestine lumen groups carbohydrates called lack known collective term reducing dietary intake also hypothesized abdominal symptoms patients ibs alleviated patients visceral sensitivity low diet subsequently designed last years mechanisms action food content efficacy diet among aspects intensively studied many parts world low diet now considered front line therapy ibs
obesity insulin resistance recognised leading causes major health issues particularly diabetes type metabolic syndrome although obesity defined excess body fat frequently accompanied insulin resistance diabetes metabolic syndrome cardiovascular diseases molecular basis link obesity diseases yet clarified adipose tissue expresses various secretory proteins including leptin tumour necrosis factor alpha adiponectin involved regulation energy expenditure lipid metabolism insulin resistance aim study provide overview metabolic alterations occurring insulin resistance review biological roles adiponectin particularly regulation fatty acid oxidation insulin action adiponectin abundant gene product adipose tissue accounts total plasma protein plasma adiponectin level decreased obesity children adults negatively associated plasma insulin positively associated plasma triglycerides low levels adiponectin decreases fatty acid oxidation muscle recent data demonstrated adiponectin effects mediated interaction muscle hepatic receptors activation amp kinase cellular fuel gauge turn inhibits acetyl coa increases fatty acid beta oxidation since available recombinant adiponectin human use direct effects human metabolism remain unknown hormone appears promising treatment obesity related metabolic disorders elsevier ltd rights reserved
past research shown gender faces affects leadership selection irrespective candidates gender masculine facial appearance congruent masculine leadership roles thus masculine looking certainly feminine looking ones present study extended line research investigating decisions masculine feminine professional roles furthermore used eye tracking examine visual exploration results indicate masculine looking favored masculine role leader feminine looking feminine role team member eye movement patterns showed information gender category facial appearance integrated first decisions however based initial analysis occurred second stage viewed context considering specific job
efficient exploitation distributed computing infrastructures needed deal data scientific community facing particular one due emerging square array reach data rates domain hence science enriched advanced tools enable scientists build experiments also optimize adaptation different infrastructures work present method called two level workflow system build kind tools apply set analysis tasks interest use applications method uses software service model keep scientists technical complexity programming model achieve efficient use computing resources
air pollution meteorological factors metropolitan areas increased emergency department visits people chronic obstructive pulmonary disease copd studies investigated associations air pollution meteorological factors copd related health disorders asian countries study aimed investigate relationship environmental factors copd associated visits susceptible elderly population largest taiwanese metropolitan area area including city new city data air pollutant concentrations meteorological factors daily temperature relative humidity air pressure daily copd associated visits collected taiwan environmental protection administration air monitoring stations central weather stations taiwan national health insurance database area used case crossover study design conditional logistic regression models odds ratios ors confidence intervals cis evaluating associations environmental factors copd associated visits analyses showed significantly greater lag effects lag days days copd associated visits elderly population years old days significantly greater effect elderly copd associated visits estimated coexistence additionally either combined air pollutants increased risk elderly copd associated visits days high relative humidity air pressure difference respectively study showed joint effect urban air pollution meteorological factors contributed copd associated visits susceptible elderly population largest metropolitan area taiwan government authorities review existing air pollution policies strengthen health education ensure health susceptible elderly population elsevier ltd rights reserved
background myeloproliferative neoplasms mpns group chronic hematologic malignancies carry significant physical psychological symptom burdens significantly affect patients quality life objectives sought identify relationship early childhood adversity psychological distress patients mpns compound symptom burden methods patients mpns assessed risky families questionnaire subscales include home environment distress distress problem list anxiety hospital anxiety depression scale anxiety depression hospital anxiety depression scale depression meeting standardized cutoff thresholds distress distress problem list demographic factors results total participants completed study response rate associated depression anxiety distress essential thrombocythemia taking antidepressant conclusion associated psychological distress meets screening criteria anxiety depression patients mpns help explain individual patient trajectories understanding enhance patient centered care among patients mpns
background cellular stressors apoptosis inducing agents shown induce ribosomal rna rrna degradation eukaryotic cells recently rna degradation vivo observed patients locally advanced breast cancer mid treatment tumor rna degradation associated complete tumor destruction enhanced patient survival however clear widespread chemotherapy induced rna disruption extent associated drug response underlying mechanisms methods ovarian breast mda mcf cancer cell lines treated several cytotoxic chemotherapy drugs total rna isolated rna also prepared resistant resistant cells following drug exposure disruption rna analyzed capillary electrophoresis northern blotting performed using probes complementary rrna determine origins degradation bands apoptosis activation assessed flow cytometric monitoring iodide binding cells measuring caspase activation link apoptosis rna degradation disruption investigated using caspase inhibitor results chemotherapy drugs tested capable inducing similar rna disruption patterns treatment resistant cells treatment cells result rna disruption northern blotting indicated two rna disruption bands derived end rrna staining treated cells along assessment caspase activation showed concurrent initiation apoptosis rna disruption inhibition caspase activity significantly reduced rna disruption conclusions supporting vivo evidence results demonstrate rna disruption induced multiple chemotherapy agents cell lines different tissues associated drug response although present link apoptosis rna disruption completely understood evaluation rna disruption thus proposed novel effective biomarker assess response chemotherapy drugs vitro vivo
food insecurity among children families negatively affects childrens health link household resources food insecurity established family income alone explain food insecurity neighborhood disadvantage shown affect areas childrens development also play role food insecurity study examines associations neighborhood poverty childrens food insecurity whether family characteristics account identified associations data age children early childhood longitudinal study cohort data poverty rates american community survey food access food environment atlas using childrens residential census tracts children tracts using series multilevel models test associations neighborhood poverty household economic demographic parenting characteristics food insecurity child adult household levels children living higher poverty neighborhoods likely experience food insecurity lower poverty neighborhoods associations neighborhood poverty household adult level food insecurity household characteristics controlled however living high poverty neighborhood remains predictive child level food insecurity indicator severe findings indicate neighborhood poverty useful proxy identify vulnerable children elsevier ltd rights reserved
functional errors analog portion mixed signal circuits become severe improvements verification methods increasingly important current verification methods fall two categories simulation based verification formal verification focusing verifying analog circuit function performance paper proposes novel approach verifying analog circuit design using causal reasoning causal reasoning inductive reasoning process create new design flow begins mining causal reasoning steps design plan produced circuit including starting ideas design step sequence topological features corresponding starting ideas design step sequence verified individually replacing related devices ideal behavior model performance evaluated cadence simulation comparison new circuit performance reveals incorrect functional issues performance potentials improvement negative causes certain starting ideas design steps design process paper discusses three operational amplifier designs realized cmos technology illustrate verification approach elsevier rights reserved
advent multilevel inverter topologies path realization renewable energy based various classes consumers topologies offering concerns design complexity power quality stresses capacitor voltage balancing etc view challenges paper proposes simple modular cascaded multilevel inverter modified polar shifted carrier pulse width modulation pwm topology proposed topology eliminates use diodes capacitors requires input voltage used conventional topology produce amount output voltage leads reduction switching devices rating stresses proposed pwm reduces magnitude hazardous lower order harmonics shifting higher order components around region integral switching frequency thus proposed pwm topology simplifies design multilevel inverters along advantages analysis microgrid modelling simulations carried matlab simulink effectiveness proposed topology evaluated calculating various power quality indices dynamic nonlinear loading conditions indices compared conventional topology respect standard results observed proposed topology improved power quality along elimination inherent problems multilevel inverters enhances microgrid towards smart net zero energy buildings elsevier rights reserved
chances raising crop productivity enhance global food security greatly improved complete understanding biological mechanisms traits crop yield disease resistance nutrient water use efficiency crop genomes emerging time basic information gene level begin crop gene using data plant species understand genes function interactions govern crop development physiology unfortunately task creating complete knowledge base gene functions interaction networks trait biology technically challenging relevant data dispersed myriad databases variety data formats variable quality coverage paper present general approach building knowledge networks provide unified representation heterogeneous interconnected datasets enable effective knowledge mining gene discovery describe datasets outline methods work flows tools developed creating networks major crop species wheat present global characteristics knowledge networks example linking seed size phenotype transcription factor arabidopsis illustrate value integrated data biological knowledge discovery software developed knowledge resources http created open source provide first step towards systematic evidence based gene discovery order facilitate crop improvement authors published elsevier open access article license
objective investigate relationships pain stress social support sleep disturbance among diverse sample hiv positive adults method participants completed self report measures pain stress social support sleep disturbance cell count obtained medical records results greater pain stress associated greater sleep disturbance greater assistance friends associated greater sleep disturbance whereas greater understanding friends regarding participants hiv related stress associated less sleep disturbance conclusion expected pain significantly associated sleep disturbance additionally psychosocial variables strongly associated sleep type support friends differentiated whether support positively negatively associated sleep problems social support depending type always helpful adults living hiv aids future studies need examine factors mediate relationship psychosocial constructs healthy sleep elsevier inc rights reserved
objective although hispanic adolescents usa often focus sexual health interventions response survey measures rarely assessed within evaluation studies study documents test retest reliability wide range self reported sexual health values attitudes knowledge behaviours among hispanic adolescents low income urban communities method correlation coefficients calculated sexual health scales knowledge values condom use parent communication protection self efficacy condom use intentions week sample cohens kappa correlation coefficients calculated behaviours romantic sexual behaviours sexual health services history two separate week samples selected behaviours also examined week samples year sample results among sexual health scales test retest reliability ranged condom use intentions parent communication among behaviours reliability ranged use sexual health services use birth control first sex ranged ever steady partner sexual health services testing conclusion test retest reliability differed greatly across self reported sexual health values attitudes knowledge behaviours three samples hispanic adolescents overall however items scales showed good excellent reliability coefficient greater suggesting hispanic adolescents moderately highly stable response sexual health measures
background psychosocial phenotype interstitial bladder pain syndrome condition without known organic causes proposed psychosocial variables including interpersonal maltreatment negative affect studied association specificities relationships childhood trauma close others psychiatric dysfunctions negative affect post traumatic psychopathology symptoms established methods patients recruited together patients acute served clinical controls standardized scales used assess various potentially events childhood adulthood psychiatric dissociation negative affect symptoms results among potentially events close others childhood found salient features discriminating group control group divided subgroups according history childhood trauma close others patients childhood trauma close others anxiety symptoms compared control group two subgroups differ symptom severity conclusions childhood trauma close others rather types interpersonal trauma differentiating characteristic patients childhood trauma related psychosocial phenotype distinct clinical profile dissociation anxiety identified future studies investigate whether distinct set pathogenic factors exists patients history childhood trauma close others even subgroup readily differentiated symptoms elsevier inc rights reserved
combine complementary strengths human vision computer vision target image retrieval proposed brain computer interface framework bayesian retrieval couples bayesian method retrieve target images rapid serial visual presentation sequences construct suited eeg decoding module conducted comparative inspection selection classification algorithms adopted linear discriminant analysis random forests feature extraction method classification algorithm respectively also introduced system based convolutional neural network cnn component bayesian brain computer interaction module carefully designed presented image bayesian model takes insight prior information insights sample information built present retrieval results unlike existing coupled works usually require extra manual labor directly enhanced retrieval performance help insights auxiliary work natural extension proposed probability propagation scheme incorporates eeg decoding insights improve system one shot image database retrieval scheme demonstrated effectiveness extensive experiments simulations entire framework sub components results showed following performance significantly better eeg mechanism receiver operating characteristic roc classification aspects robustness ensured process flow steady performances sub components elsevier rights reserved
objective prevalent disorder characterized chronic widespread pain complex symptoms study conducted investigate potential therapeutic effect low dose irradiation alone combination induced induced administration consecutive days administered forced swimming test rats exposed single dose radiation significantly increased immobility time decreased amount dopamine cerebral cortex also increased malondialdehyde nitric oxide reduced glutathione contents brain tissue alone combined completely induced assessed measured parameters one significant findings study therapeutic effect pronounced combination possible mechanism action responsible therapeutic effect basis presented evidences concluded alone combined value management
paper conduct research development applications innovative concept modern architecture design green environmental protection perspective emergence development concept green building met need long term development chinese society also inevitable trend era development current situation due effect construction technology environment green building construction also certain problem green buildings also certain difficulties development society progress theoretical research green building also constant innovation believe development prospect research proposes novel paradigm architecture design innovative meaningful
statistical data available number employees working night shifts turkey working shifts associated decreased sleep time decreased daily sleep quality decreased night shifts increased incidences cardiovascular disorders ulcers types cancer shift workers known exposure light suppresses melatonin production non synchronized circadian rhythm disturbed melatonin secretion lead excessive sleep carbohydrates weight gain melatonin hormone sleep seems key regulator sleep wake rhythm exposure light night disturbance circadian rhythm contribute health problems night shift workers melatonin production review definitions social delayed sleep phase syndrome insomnia discussed sleep disorders psychiatric diseases reviewed drugs available market listed including side effects sleep sleep disorders depression melatonin given extended discussion two recent reviews effect melatonin sleep patterns discussed finally treatments sleep disorders summarized conclusion shift workers sleep problems complex subject multiple pathophysiological mechanisms play roles double blind randomized controlled studies systematic reviews meta analyses conducted provide weakly positive data beneficial effect melatonin use shift workers future multi centered multi participant studies light issue
proactive computing systems act eliminate mitigate take advantage previous knowledge manipulate situations interest advance behavior critical ambient assisted living systems paper present semantic models design implement proactive systems home care environments implemented devices sensors models support semantic interoperability physical environments different software levels allowing identification user context obtained construction suitable actions plan results consumption services provided devices services one challenge model high level situation select particular device best meets users needs considering context location disabilities paper describes steps required create generic flexible model extended incorporate new domain knowledge regarding specific requirements different ambient assisted living systems
essay offers paths scholars influenced critical social sciences theoretical contribute construction concepts digital practices data allow data better align approaches scholarly inquiry particular explores geographic information simplified theoretical positions drawn inquiry process relational thought new geographic information largely called forth self sufficient entities intensive properties indexed location absolute space known objectively geographic gaze contrast article suggests ways geographic information constitute spaces relational matter knowledge situated claims seen boundaries previously considered roles reader researcher data structures observer observed also need implications ways interface data although paths difficult travel hold promise extending reach non empirical practice favorably altering terms scholars participate debates around practices data today
bond topical interaction rapidly increasing importance employs soft donor atom comparison hard proton hydrogen bond difference led hypothesis form favorable interactions soft bases computational studies supported suggestion solution solid state data lacking soft soft investigated receptor shows similar associations neutral heavy analogs solution soft soft supported four crystal structures containing neutral soft bases
experiment manipulated elite endurance implicit beliefs nature decision making ability explored subsequent change performance decision making task physiological load total elite level endurance women men manipulated endorse limited susceptible depletion depletion implicit belief decision making ability results showed manipulation assigned limited resource condition higher levels limited beliefs lower levels beliefs assigned resource condition limited resource condition also showed decrease decision making performance whereas resource condition showed increase decision making performance findings suggest implicit beliefs decision making ability manipulated elite sport sample manipulation alter performance decision making task physiological load
development mammalian relies heavily proportion cell population varies considerably different mammalian species almost undetectable forms thin distinct layer mouse rat larger layer big mammals pig highly developed embryonic structure human non human primates evolutionary origin neurons subject current debate hypothesize represents cortex others consider increasingly complex phylogenetic novelty mammalian review recent work expression several genes originally identified rodent highly differentially expressed relate observations cellular morphology dorsal cortex dorsal several species based reviewed evidence argue third hypothesis according contains newly derived cell populations propose mammalian originally derived ancient structure dorsal stem subsequently expanded additional cell populations lineage support increasingly complex cortical plate development understanding detailed molecular taxonomy morphology connectivity comparative context contribute identification newly evolved populations neurons
increasing applications ionic liquids toxicity drawn increasing attention recent years especially influences different chain lengths acute toxicity aquatic organisms performed study acute toxicity nitrate zebrafish also evaluated investigated animals stability water via high performance liquid chromatography hplc technologies inc usa prove reliability present study results illustrated test zebrafish sensitive reference investigated water stable lethal concentration used represent acute toxicity zebrafish present study showed highest toxic lowest toxic different similar values accordingly believe different chain lengths cause greater effects acute toxicity aquatic organisms furthermore present study also provide scientific methods future studies select assess
condition dependence male sexual traits plays central role sexual selection theory relatively little however known condition dependence chemical signals used choice subsequent effects male mating success furthermore studies isolated specific nutrients responsible condition dependent variation male sexual traits used nutritional geometry determine effect protein carbohydrate intake male hydrocarbon expression mating success male show traits maximized moderate high intake nutrients ratio also show female choice exerts complex pattern linear quadratic sexual selection condition dependent variation male expression structural revealed although effect nutrient intake mating success mediated condition dependent expression exclusively suggesting traits also play important role collectively results suggest complex interplay nutrient intake expression mating success plays important role operation sexual selection
nowadays smartphone plays important role lives brings convenience efficiency overuse cause problems although great number studies demonstrated people affected substance abuse pathological gambling internet addiction disorder lower self control average study investigated decision making smartphone high users using behavioral paradigm present study employed task smartphone addiction inventory scale version bis explore decision control smartphone high users sample college students participants divided three groups according scores upper third higher middle third lower third lower scores defined high smartphone users medium users low users respectively compared percentage small immediate reward penalty choices different conditions three groups relative low users group high users medium users inclined request immediate monetary reward moreover two dimensions time money choice high users medium users showed bias choice task among time points value magnitude compared low users findings demonstrated smartphone overuse associated problematic decision making pattern similar seen persons affected variety
mac binding protein mac secreted tumor antigen elevated many cancers implicated tumor metastasis cell adhesion immune functions focused human reverse transcriptase induced mac expression relationship mac expression progression gastric cancer cdna expression array analysis performed negative cell line engineered compared parental cell induced mac expression confirmed via pcr northern blotting elisa flow cytometric analyses revealed mac protein increased fold overexpressing cells compared mock control mac expression significantly reduced overexpressed introduction specific sirna results suggest mac expression modulated mac levels gastric cancer cells tumor tissues determined via northern blot analysis immunohistochemistry mac protein highly expressed gastric cancer cell lines gastric tumor tissues stained normal tissues intracellular secreted mac levels also evaluated elisa indicating mac expressed secreted abundantly gastric cancer patients healthy donors elevated serum mac level gastric tumor patients also significantly associated distant metastasis higher tumor stage findings suggest mac induced prove useful prognostic marker detection malignant progression metastatic stomach cancers wiley liss inc
study evaluated effects inhalation essential oil vital signs open heart surgery icu main complaint patients open heart surgery hypertension due stress pain due side effects chemical drugs opioids use non invasive methods stress pain parallel chemical agents important way decrease dose side effects multicenter single blind trial patients open heart surgery recruited inclusion criteria full consciousness lack hemorrhage heart rate min systolic blood pressure mmhg diastolic blood pressure mmhg using beta blockers operating room icu history addiction opioids use regular spontaneous breathing ability receiving synthetic opioids within ten minutes patients vital signs including central venous pressure measured cotton drops essential oil placed patients oxygen mask patients min thirty minutes vital signs measured main objective study change vital sign statistical significance accepted significant difference systolic blood pressure diastolic blood pressure heart rate intervention using paired test although results show significant difference respiratory rate essential oil therefore effectively reduce blood pressure heart rate patients admitted open heart surgery icu used independent nursing intervention stabilizing mentioned vital signs limitations study sample size lack control group randomized clinical trials larger sample size recommended
problem vehicle lateral stability control fully electric vehicles addressed paper using two different approaches one novel integrated lateral stability control system second one regenerative braking based lateral stability control system proposed system based corrective moment calculation braking torque distribution electric motor torque reduction proposed second method simpler method system method electric motor torque regulated according vehicle side slip error vehicle rate error performances proposed methods evaluated severe road conditions extreme using commercially available vehicle dynamics software results show proposed control systems improve vehicle lateral stability significantly
purpose present study record incidence knee injuries relation event exercise phase two hundred aged years different north south greece participate study seasons authors twice week registered injury occurred practice event made miss next practice event session results showed sustained knee injuries landing mainly floor routines causing ligament sprains injuries occurring pre competition season usually training time furthermore knee injuries take phase occurred mainly forward rotation exercises first competition level mainly use supplementary soft training restrict pressure knee joints landing phase control amount effort reduce possibilities increase knee injuries especially particular age group
many institutions globally advanced use brings positive benefits towards development quality education success institution depends information communication technologies utilised good quality standard design content websites meet needs students particular however benefits challenges discussed variety studies globally moreover understanding students attitudes perceptions towards critical issue improving value use systems tertiary education strength materials information technology management two technology courses research conducted part time students unable attend courses day due various reasons therefore researchers interest identity assesses effectiveness teaching learning processes main challenge improve current pass rates hence research aims investigate students attitudes perceptions effectiveness using system teaching learning processes action research process evaluated end implementation cycle active students registered two courses whereby questionnaire distributed identify views perceptions experiences challenges benefits system however believed need calling better quality education application accessibility speed process transforming education also understanding students attitudes toward significant improving usage results
research informed methods case conceptualization cut across traditional therapy approaches increasingly popular paper presents trans theoretical approach case formulation based research observations emotion methodsthe sequential model emotional processing process research model provides concrete markers therapists observe emerging emotional development clients illustrate model used clinicians track change provides clinical map therapist session plan treatment interventions processing offers trans theoretical framework therapists wish conduct emotion based case formulations first present criteria research model translates practice second two contrasting case studies presented demonstrate method conclusionsthe model bridges research practice using client emotion axis integration key practitioner message process research emotion offer template therapists make case formulations using range treatment approaches sequential model emotional processing provides process map concrete markers therapists observe emerging emotional development clients help therapists develop treatment plan copyright john wiley sons ltd
switching cost important factor policy makers consider sets higher price locked consumers making market less competitive though empirical research analyzing switching costs mobile market studies considering characteristics smartphones operating systems applications still rare study conduct hypothetical survey analyze switching cost smartphone market derive cost using hierarchical bayesian multinomial model consider respondents heterogeneity switching costs empirically estimated magnitudes depend levels searching cost learning cost uncertainty new smartphones elsevier ltd rights reserved
ambient intelligence next wave computing communication technology nano sensors wireless networks unified intelligent software main elements issue inputs ambient intelligence taken sensors environment wireless sensor networks consists small low cost sensors collect report environmental data wireless sensors dispersed area phenomenon event monitored sensor detects monitored event heat pressure sound light areas magnetic properties vibration etc event reported one sites site performs appropriate task sending message local processing based type network provides appropriate response one major challenges wireless sensor networks optimizing energy consumption studies shown clustering network nodes possible use energy efficiently study proposes clustering based routing method used wireless sensor networks multi objective optimization algorithm named non dominated sorting genetic algorithm used clustering seven objective functions described aimed carry several goals using multi objective algorithm communication cost objective functions cluster head sink cluster head non cluster head tried minimized selection cluster heads nodes near sink also tried prevented also taken consideration clusters include nodes much possible solution solution set obtained non dominated sorting genetic algorithm points different network topology solution solution set best solution according objective functions provided sink simulate solution solution set according certain scenario choose one suitable desired criteria proposed method operating non dominated sorting genetic algorithm simulation evaluation obtained solutions comes sink sufficient operation power sources according results proposed method make life span network five times longer famous clustering algorithm besides proposed method extends life span network also seen increases number packet reaching sink two times data provided proposed method includes information larger areas compared elsevier ltd rights reserved
tools allow isolated functional investigations almost signaling molecule within complex signaling pathways major obstacle controlled delivery light cell sample hence popular tools studies microscopy based cell analyses vitro experiments flow major advantages microscope including ability rapidly measure thousands cells single cell resolution however yet widely used present device combines power flow cytometry led thermo flow device cells specific wavelengths light intensities temperatures flow cytometric measurements built low cost used common flow demonstrate utility characterized kinetics proteins vivo real time protocol adapted almost controlled substances substantially expands set possible experiments importantly greatly simplify discovery development new tools
recently discovered beta induces expression mouse vivo vitro however molecular mechanisms exerts biological effects elucidated purpose study explore signal transduction pathway involved mrna induction using keratinocyte cell line northern blotting performed analyzing human mrna expression levels combination number protein kinase including specific inhibitor cat assays gene cat construct conducted examining transcriptional regulation free radical used analyzing role oxidative stress gene induction increased gene transcript levels cat activity dose dependent fashion cells increase mrna levels cat activity completely suppressed addition prevented inducible promoter activation furthermore suppressed inducible promoter activation results demonstrate potent activator gene promoter activation reactive oxygen species implicated inducible gene expression useful tool signal transduction pathway mediating promoter activation
discretization introduced method images context deterministic radio propagation modeling way exploit spatial coherence electromagnetic propagation fine grained parallelism traditional algebraic treatment regions surfaces replaced computer graphics rendering reflections double building image tree visibility reception points surfaces also resolved programs proposed shown comparable run time fundamentally parallel rays affect signal evaluation step thus preserving advantage force ray tracing methods terms accuracy moreover rendering resolution scaled back given level scenario detail marginal impact image tree size allows selection scene optimized execution parameters faster execution giving method competitive edge proposed variant run gpu supports real time graphics
background approximately rural households rely biomass fuels cooking international study asthma allergies childhood estimates prevalence current among children nigeria approximately objective examine effects biomass smoke exposure asthma symptom prevalence rural children nigeria methods conducted cross sectional survey rural communities nigeria asthma symptoms defined according definitions biomass smoke exposure determined types fuel used cooking logistic regression used explore associations biomass smoke asthma symptoms results study population comprised school children lived households cooking biomass lived households using biomass asthma symptoms reported children biomass fuel associated increased odds asthma symptoms adjusted odds ratios nocturnal cough current report asthma related symptoms sex modified associations asthma symptoms biomass fuel stronger significant males nocturnal cough current report asthma related symptoms weaker non significant risk asthma symptoms related biomass smoke exposure appears differ sex
commonly expressed subtle surfaces rather large void systems penetrating deeply subsurface contrast regional island canada associated exceptional exposure large intact diameter tens high distributed along horizontal plane associated network present base filled formation preservation features require aggressive dissolution along stable water table shortly deposition shallow marine sand network acted flowing groundwater discharged shallow marine sand producing water escape structures sand preserved cylindrical sand pipes sediment probably caused variations hydraulic head gradient lens near tropical climate abundant probably variable rainfall caused pulses subsurface fluid flow spatial distribution sand suggests formation southeast side recently formed island early sea level rise structures reported generally difficult interpret owing lack data fluid hydraulics underlying aquifer first report linking hydraulics characterised development fluid escape structures structures widely known sub around circumference elsevier rights reserved
input output weight convolutional code characterizes distance spectrum allows error probability bounds conveniently evaluated efficiently compute weight recently introduced called state reduction algorithm convenient implementation using existing symbolic mathematical software paper propose dynamic state elimination ordering heuristic accelerate algorithm demonstrated empirical results accelerated state reduction algorithm achieve impressive complexity savings relative original algorithm applied compute weight various truncated versions convolutional codes moderate large constraint lengths
major application domain vascular ultrasound carotid artery long subject phantom design nevertheless trivial develop walled carotid compatible use integrative imaging carotid wall motion flow dynamics paper present novel phantom design protocol enable efficient fabrication walled carotid bifurcation high acoustic compatibility artery like vessel elasticity feature protocol first involved direct fabrication vessel core outer using computer aided design tools printing technology built parts used construct elastic vessel tube investment casting alcohol containing mixture agar tissue mimicking formed around vessel tube demonstration applied protocol develop set healthy carotid bifurcation plane wave imaging experiments performed using ultrasound scanner channel level results show wall motion dynamics agreed pulse wave propagation elastic vessel pulse wave velocity measured common carotid artery flow dynamics matched expected ones healthy bifurcation recirculation flow jet formation observed integrative imaging vessel wall motion blood flow dynamics also demonstrated observed fluid structure interaction differences healthy diseased bifurcation findings show walled bifurcation developed new protocol useful vascular imaging studies individually jointly assess wall motion flow dynamics
experimental study conducted investigate influence confinement behavior longitudinal steel reinforcing bars columns subjected monotonic cyclic axial compression test results confined columns confined plain concrete columns control specimens presented particular attention evolution strains longitudinal steel load increases confined column subjected monotonic axial compression contribution longitudinal steel overall axial load carried column deduced contribution confined plain concrete total axial load test results showed compressive stress strain response longitudinal steel confined columns follows tensile testing axial stress reduces gradually due onset deformation significant interactions found exist confinement longitudinal steel interaction carefully considered constitutive laws longitudinal steel confined concrete use theoretical modeling elsevier ltd rights reserved
electromagnetic design min high speed permanent magnet motor carried based analysis pole number stator slot number rotor outer diameter air gap length permanent magnet material thickness pole arc load full load performance investigated paper using finite element method fem addition power losses including core loss winding loss rotor eddy current loss air friction loss predicted based analysis prototype motor manufactured experimentally tested verify machine design
although much knowledge enzymology genes coding proteins lipid biosynthesis higher plants relatively little attention paid regulation demonstrated important role biosynthesis major extra membrane lipid followed work applying control analysis light induced fatty acid synthesis first application lipid synthesis organism data showed acetyl coa important exerting half total control applied metabolic control analysis lipid accumulation important oil crops olive recent data soybean show block fatty acid biosynthesis reactions exerts somewhat control lipid assembly although clearly important results suggest gene targeting parts overall lipid synthesis pathway needed increase significantly oil yields soybean article part special issue entitled membrane structure function relevance cells physiology pathology therapy elsevier rights reserved
result rapid growth popularity portable digital devices recent years power requirements computer operating systems used devices also rapidly increased complexity processing power increased compared systems based main memory pcm phase change memory new memory technology significantly reduce power consumption data stored pcm device powered paper first discuss several pcm ram based hybrid systems systems amount read data influences design hybrid structure experiment section found almost data semi read
agriculture nearly cultivated area home human livestock population india contributes food production even full realizing full irrigation potential country half cultivated area continue farming highly dependent rainfall widely believed increasing rainfall variability likely affect millions small marginal farmers years come national initiative climate resilient agriculture initiated primarily strengthen research address climate change demonstrate proven resilient practices climate vulnerable parts country participatory technology carried since vulnerable districts prone recurrent drought floods extreme weather events like heat cold wave interventions broadly fall four modules related natural resource management crop livestock production systems capacity building three years rainfall variability delayed onset prolonged breaks experienced several parts country total interventions impact resilience situ soil moisture conservation rainwater harvesting efficient recycling demonstrated resulted significant increase crop yields even variable rainfall situations short duration drought flood tolerant varieties pulses crops demonstrated covering farmers adaptation gains ranging climate resilient practices technologies found promising national mission sustainable agriculture government initiative enhancing productivity resilience indian agriculture accordance stated aim national action plan climate change authors published elsevier
people differ implicit theories characteristics intelligence personality relatively chronic theories experimentally altered affected parent teacher feedback little known whether people selectively shift implicit beliefs response salient situational goals predicted motivated reach desired conclusion people shift implicit theories change stability supporting evidence desired position motivated context particular lay theory help people reach preferred directional conclusion elicit shifts theory endorsement examine variety motivated situational contexts across studies finding peoples theories change shifted line goals protect self others cast others studies demonstrate people regulate implicit theories manage self view strongly incremental theory threatening performance feedback memories failure studies revealed people regulate implicit theories hold favored political candidates incremental theory preferred candidates past toward entity theory ensure past finally study people threatened previously child sex parents reading moving neighborhood entity view others change although chronic implicit theories undoubtedly meaningful research reveals previously unexplored source highlighting active role people play managing implicit theories response goals
background objectives negative symptoms schizophrenia related lower social functioning even non clinical samples little known distinct social consequences motivational expressive negative symptoms study focused expressive negative symptoms examined symptoms varying degrees pro social facial relate social evaluations face face interaction partners social support methods examined dyadic interactions within sample non clinical participants rated motivational expressive negative symptoms clinical assessment interview negative symptoms collected data interaction partners muscle major activation simultaneously assessed general amount muscle activations interaction partners interaction partners rated willingness future interactions interactions results interaction partners participants scoring higher expressive negative symptoms expressed less willingness future interactions participants behavior negatively related expressive negative symptoms also explained motivational negative symptoms negative symptom domains also associated participants satisfaction social support network limitations non clinical sample relatively low levels symptoms conclusions expressive negative symptoms tangible negative interpersonal consequences directly relate diminished pro social behavior social support even non clinical samples elsevier ltd rights reserved
nowadays human exposed environment filling electromagnetic waves wide frequency range electromagnetic properties microwave absorbing materials plays important role performance electromagnetic interference low frequency range military stealth technology high frequency one electromagnetic properties include complex permittivity permeability combination determines electromagnetic wave absorption ability material complex permittivity permeability measured three different methods free space method method resonant cavity perturbation method first one requires large space expensive equipment suitable academic usage present study using resonant cavity perturbation methods electromagnetic characteristics iron based microwave absorbing materials obtained microwave absorption performance investigated addition comparison measurements two methods addressed
enhance thermal efficiency increase performance internal combustion engine novel concept coupling conventional engine secondary stroke cylinder direct water injection process proposed gases working traditional stroke combustion cylinder transferred secondary cylinder expanded even compression exhaust gases pre heated water injected top dead center evaporation injected water heat exhaust gases also increases mass working gas inside cylinder therefore improves overall thermal efficiency model used numerically simulate idea simulations outputs showed cycle efficient higher engines speeds engine higher exhaust gas pressure reproduce positive work modeled engine results showed brake thermal efficiency improved brake power
nearly half million infants united states born preterm low birth weight year providing women prior adverse birth outcome access family planning help reduce incidence subsequent high risk pregnancies adverse outcomes one effective option prevent unintended pregnancy women prior adverse birth outcome either use contraception consistently whose contraception fails emergency contraception purpose study understand willingness use among african american women recently adverse birth outcome healthy births healthy communities care project targeted high risk african american women two low income neighborhoods recently adverse birth outcome aim improve participants future birth outcomes providing medical social services helping women clarify reproductive life goals information participants pregnancy intentions willingness use measured interview shortly enrollment study women study either want become pregnant know wanted become pregnant within next years women times higher odds reporting willingness use compared women reported desire become pregnant within next years respectively aor essential part reproductive toolkit women high risk adverse birth outcomes pregnancy along reproductive life planning use effective contraception
understanding dynamics including variations population size dispersal affect epidemiology infectious diseases ecological evolutionary processes active research area focus bank surveyed finland bank reservoir agent mild form hemorrhagic fever renal symptom humans populations experience density fluctuations influence level genetic diversity maintained bank prevalence occurrence examine bank genetics presumably neutral markers genes involved susceptibility tnf promoter gene investigate links population dynamics processes epidemiology show genetic drift slightly transiently affects neutral adaptive genetic variability within gene flow seems effects density fluctuations low abundance phase therefore short impact genetic variation host consequently viral genetic diversity environmental heterogeneity seem affect gene flow explain absence spatial structure previously detected area besides results suggest role dispersal circulation sex specific density dependent movements find little evidence selection acting immune related genes within footprint positive selection detected gene observe marginally significant associations genotype results show neutral processes seem main factors affecting evolution immune related genes contemporary scale although relative effects neutral adaptive forces vary temporally density fluctuations immune related gene polymorphism turn partly influence epidemiology published elsevier
optimal management large environmental systems often limited high computational burden associated process based models commonly adopted describe systems paper propose novel data driven dynamic modelling approach construction small computationally efficient models accurately main dynamics original process based model less computational requirements approach combines many advantages data based modelling representing complex non linear relationships preserves state space representation particularly effective several applications optimal management data assimilation facilitates post physical interpretation structure thus enhancing credibility model stakeholders decision makers core mechanism novel variable selection procedure applied data set input state output variables generated via simulation process based model approach demonstrated real world case study concerning optimal operation selective withdrawal reservoir dam japan suffering downstream water quality problems identified data set generated coupled hydrodynamic ecological model subsequently used design optimal operating policy dam preliminary results show proposed approach significantly simplifies learning good operating policies highlight interesting properties system controlled elsevier ltd rights reserved
time fluorescence microscopy valuable technology cell biology suffers inherent problem intensity due uneven illumination camera nonlinearity known lead inaccurate estimates single cell features average total intensity numerous correction methods proposed remove effect order compare performance different methods many quantitative performance measures developed however little discussion performance measure generally applied evaluation real data ground truth absent paper state art correction methods performance evaluation methods reviewed implement popular correction methods two artificial datasets four real ones order make objective comparison methods employ number quantitative performance measures extensive validation demonstrates coefficient joint variation applicable measure time fluorescence images based measure proposed novel correction method performs better compared established methods range real data tested
conflict caused extreme suffering threatened existence identity integrity caused half population internally become goal current study assess physical mental health toll experience intergroup trauma individuals sample internally administered measures experience cumulative stress trauma posttraumatic stress disorder ptsd stress trauma disorders complex ptsd anxiety descriptive statistics showed high rates ptsd comorbidities suicidality internally significantly higher morbidity rates using path analysis tested model mediated interpersonal triggered affected severely mental physical health model fitted tested models structural invariance across genders groups model conceptually invariant across groups strongly strictly invariant examined dynamics behind similarities differences discussed need resolve conflict develop evidence based interventions help relieve suffering
extremely large complex projects numerous geographically distributed stakeholders experience substantial risks related interfaces among stakeholders particularly true project definition design despite discrete across interfaces decisions require iteration managing interfaces become feasible advent internet electronic product process management systems extent full time interface management positions exist practice however lacks formal structure integration critical path method scheduling methods identify high risk interface points throughout paper graph based algorithm developed identify key network capital project furthermore new approach discussed link key interface identify schedule related risks mitigate adverse impact functionality proposed algorithms demonstrated offshore model project contributions paper provide material research american society civil engineers
known sarcoma malignant neoplasm caused pathogen leads endothelial cell transformation host weakened case report first case treatment biologic agent targeting cell patient year old female rheumatoid arthritis developed multiple firm nodules dorsal aspect right hand histological examination confirmed new direct causal relationship development treatment proved hypothesize role blockade
paper demonstrates multi plate ion balance analyzer inverse distance weighted interpolation characterizing performance proposed analyzer design uses ultra high input impedance charge induced meter measure electrostatic potential multiple ion receiving plates embedded microcontroller processes multi channel analog signals presents results graphical display data interpolation enables high resolution results multi plate measurements developed analyzer suitable ion balance characterization small footprint devices sensitive electrostatic discharges single chip integrated circuit head assembly hard disk drive elsevier rights reserved
regulation three important physiological processes described heart respiration early activity regime submitted modulating effects dopaminergic mechanisms considered age related changes effect whose polar changes reactions process maturation predominantly excitatory reactions early stages predominantly inhibitory ones
used manufacture acetate component base production potential toxicity reproduction examined combined repeated dose reproduction developmental toxicity screening study test guideline prenatal developmental toxicity screening study test guideline administered wistar rats gavage controls signs systemic toxicity parental animals either study adverse effects reproductive performance fetal development attributed treatment observed thus highest dose level tested two studies elsevier inc rights reserved
retrospective study done assess prevalence congenital hypothyroidism among children born city kingdom saudi arabia years data collected newborns registry central hospital prevalence congenital hypothyroidism per live births gender difference
nano device exhibits unique hysteresis loop switching mechanism ability remember last state interesting characteristics encourage researchers understand new device develop potential applications problem yet available current market due cost technical difficulties fabrication nanoscale device thus way develop model paper spice models selected behaviors compared physical verify model similarity actual device next new approach cmos application proposed circuit spice model cmos circuit presented circuit composed write circuit program resistance read circuit read current using operational amplifier current mirror circuit important incorporate cmos cmos application studies
anxiety depression frequently occur borderline personality disorder relatively little research examined presence borderline personality features main domains affective instability identity problems negative relationships self harm individuals current anxiety depression participants current anxiety depression healthy controls selected netherlands study depression anxiety assessments included personality assessment inventory borderline features scale several clinical characteristics anxiety depression borderline personality features common depression anxiety current comorbid anxiety depression associated borderline personality features anxiety depression status explained variance borderline personality features self harm identity problems variance four domains large part variance shared anxiety depression disorders also explained significant amount unique variance severity anxiety depression level daily positively associated borderline personality features individuals longer duration anxiety depression showed affective instability identity problems findings suggest patients anxiety depression benefit assessment personality pathology implications psychological pharmacological treatment elsevier ireland ltd rights reserved
purpose study explore role health physical education specialist teacher primary school entails new australian curriculum framework requires schools teachers implement key learning area many self perceived physical education teachers concern knowing research investigates teachers best become teachers first time teachers implemented change australia many similarities drawn recent national australian curriculum national statement profile provided foundation construction recommended study look past lessons present future investigating school responses curriculum documents within paradigm study conducted methodology chosen construct meanings capturing context school evaluative multiple case study sites three case studies involved one small one medium one large sized education primary school three case studies selected representative different demographics methods engaged enable precision details semi structured interviews reflective journal observations document analysis data gathered suggest key learning area achievable implementation enhanced leadership clear communication barriers overcome professional development support study significant nationally findings wider international interest models school leaders optimise health opportunities within context models teachers become teachers
round cell characterized typical chromosomal genetic alteration result specific gene expression profiles tumor entity identify expressed genes round cell dna microarray analysis performed four tumors four samples adult fat tissue genes cyclin myc showed expression means microarray analysis northern blotting immunohistochemistry demonstrated cytoplasmic localization associated proteins different tumors localization seen endothelial cells vasculature addition accumulation tumor cells cases results show expression cyclin myc transcriptional protein level round cell cyclin finding reported tumor type increase transcriptional level explained expression endothelium blood vessels molecular pathogenesis round cell findings imply involvement four genes cell cycle especially cyclin target genes myc
parents intellectual impairment thought risk poor social emotional study investigated relationship maternal intellectual impairment poor child social emotional analysis data waves cohort study social emotional measured maternal report waves teacher child self report wave bivariate multivariate analyses conducted maternal intellectual impairment associated elevated risk overall poor social emotional ages age controlling individual family environmental characteristics statistically significant association found maternal intellectual impairment poor child social emotional mothers intellectual impairment likely peers exposed adverse living conditions living conditions explain least part children face heightened risk poor social emotional ages improving living conditions mothers intellectual impairment offer pathway child social emotional
pulsed widely used testing method offers many advantages material defect detection however existing methods pulsed data processing aim enhance defect signals single thermal image whereas automatic defect detection achieved instead time consuming visual inspection processed images required draw final conclusions usually impossible visually images therefore manual selection informative images often required step thermal image processing probably resulting necessary defect information overcome drawbacks existing methods hyper image segmentation method proposed study analyzes data achieve automatic defect detection avoid risk losing information specifically iterative defect detection procedure designed basis algorithm results case study carbon fiber reinforced plastic materials show feasibility proposed method
paper printing novel printing process considered deposition polymers synthetic fabrics introduce flexible resource efficient cost effective textile processes conventional printing process like screen printing aim develop integrated tailored production process smart functional avoid unnecessary use water energy chemicals minimize waste improve ecological footprint productivity adhesion polymer nanocomposite layers printed directly onto textile fabrics using fused deposition modeling technique investigated different variables affect adhesion properties including printing process parameters fabric type type incorporated polymer considered rectangular shape according standard designed computer aided design cad find effect different variables polymers printed different series experimental design fabrics acid fabric fabric finally carbon black multi wall carbon nanotubes nanocomposites fabrics adhesion forces quantified using innovative sample preparing method combining standard method results showed different variables printing process like temperature platform temperature printing speed significant effect adhesion force polymers fabrics direct printing model proposed specifically deposition commercial fabrics following among printed polymers composites high adhesion force fabrics authors published elsevier open access article license http creativecommonsorg licenses
one third cancer patients undergoing chemotherapy treatment often display symptoms depression leading poor adherence decreased quality life thus study aimed investigate possible protective effect associated depressive symptoms adult male rats highly adrenergic receptor blocker possesses endothelium dependent properties antioxidant capacities animals allocated four groups group one given aqueous solution cellulose served control group two given daily group three given per week consecutive weeks group four treated concomitantly per schedule treated rats showed increase depressive like behaviors open field forced swimming tests addition histopathological examination revealed cortical along hippocampal neuronal degeneration kidney dysfunction parallel administration reduced gaba elevated glutamate levels cortical hippocampal tissues furthermore resulted significant decline cortical hippocampal brain derived neurotrophic factor nitric oxide contents concomitantly marked decrease endothelial increase inducible nitric oxide synthase genes expression hand treatment effectively mitigated aforementioned associated behavioral biochemical histopathological alterations without changing antitumor activity evidenced cell survival assay taken together results suggest offer promising approach alleviating depressive symptoms associated use
high altitude integrated participatory watershed development programme implemented west north eastern indian aim assess refine practices integrating crop fish livestock production systems soil water conservation measures active participation local inhabitants included construction ponds micro rainwater harvesting structures bench half impact analysis revealed million water harvested enhanced potato rice crop productivity respectively farmers now able net around per month community dairy units fish ponds respectively
purpose study explored utility california health interview survey compare health related outcomes among gay men reported recognized partnership methods sexual identity marriage recognized partnership status seven different outcomes related health insurance coverage medical services access use general health wellbeing using data collected results respondents identified gay lesbian identified heterosexual percentage participants reported married heterosexual women heterosexual men gay men married gay lesbian respondents likely health insurance use healthcare counterparts partnerships trends statistically significant gay men recognized partnerships likely heterosexual counterparts report continuous health insurance coverage usual medical care source least one provider visit within past months found statistically significant poorer health status outcomes among recognized partnerships compared married heterosexual women conclusions recognized partnerships married heterosexual women gay men recognized partnerships better married heterosexual men measures questionnaire structures limited sample analyses recommend researchers ask status marriage sexual identity related questions ensure robust representation analyses recommendations policy resolutions
database models road based classical schemes relational databases many related tables database designer establishes priori every detail consider relevant inventory management kind database presents several problems first adapting model applications new database features appear difficult addition different needs different sets road inventory users difficult fulfil schemes example maintenance management services road authorities emergency services different needs addition kind database adapted new scenarios countries regions classify roads name certain elements differently problem complex language used scenarios used database design addition need long time learn use database efficiently paper proposes flexible multi language database model gives effective simple solution aforementioned problems authors published elsevier
existing european regulation use animals meals order prevent bovine infection diffusion however legislation rapidly moving towards partial lifting feed competent control organisms develop suitable analytical methods able avoid food safety incidents related animal origin products limitations official methods light microscopy polymerase chain reaction suggest exploring new analytic ways get reliable results short time combination spectroscopic techniques optical microscopy allows development individual particle method able meet selectivity sensitivity requirements spectroscopic method based fourier transform micro raman spectroscopy coupled discriminant analysis presented approach useful situ applications since drastically reduces time costs analysis published elsevier ltd
purpose multiple preterm birth associated maternal psychological distress less positive mother infant interactions preterm birth studys purpose compare psychological distress relationship infants mothers mothers design exploratory secondary analysis longitudinal data sample mothers preterm infants main outcome variables maternal psychological distress depressive symptoms anxiety posttraumatic stress parenting stress mother infant relationship worry child vulnerability maternal positive involvement developmental stimulation child developmental maturity irritability social behaviors home environment results mothers greater symptoms baseline anxiety discharge depressive symptoms six months mothers mothers also positive home environments six months multiple birth risk factor psychological distress less positive mother infant interactions
objective study bring policy changes respect managed aquifer recharge focusing infiltration ponds view relevant stakeholders ease problem groundwater depletion context city india groundwater needed drinking water security resulted depletion seawater intrusion current policies municipal state national level support recharge groundwater rainwater harvesting counter groundwater depletion however despite favorable policies legal framework administrative support systematic approaches towards managed aquifer recharge periphery present study confirms considering governmental key actors survey preferences motives stakeholder representatives stakeholder groups interests groundwater issues lack common vision example conflicting interest stakeholders hinder implementation certain types managed aquifer recharge methods overcome problem stakeholders support idea establish authority state licensing groundwater extraction managed aquifer recharge
last decades computer vision systems established scientific commercial applications recent developments image based reconstruction systems resulted easy way creating realistic visually appealing accurate models present fully automated processing pipeline metric geo accurate reconstructions complex geometries supported online feedback method user guidance image acquisition approach suited seamlessly matching integrating images different scales different view points aerial terrestrial different cameras one single reconstruction evaluate approach based different datasets applications mining urban environments thus demonstrate flexibility high accuracy approach evaluation includes accuracy related analyses investigating camera self calibration camera network configuration elsevier inc rights reserved
introduction energy efficiency design index water treatment regulations international organization fluctuation fuel price levels along continuous industry economic growth led industry explore new cost efficient designs various types respect proper use modern computer aided design computer aided engineering systems cad extends design space generating competitive designs innovative features short lead time present article deals parametric design optimization developed methodology based friendship framework software system demonstrated conceptual design multiobjective optimization methodology includes complete parametric model external internal geometry development coding models necessary determination design constraints design efficiency indicators used evaluation generated designs indicators defining objective functions multiobjective optimization problem herein required rate zero container box capacity ratio deck number containers set multiobjective optimization problem solved use genetic algorithms clear pareto generated identified optimal design proves competitive compared standard designs market
background patients atopic dermatitis susceptible several viruses including simplex virus patients experience episodes severe skin infection caused termed eczema numerous mouse models established model exists objective sought establish characterize mouse model methods infected like skin lesions induce severe skin lesions dermatitis prone mouse strain gene expression investigated using microarray quantitative pcr antibody titers measured means elisa natural killer cell cytotoxic cell regulatory cell follicular helper cell populations evaluated using flow cytometry role cells induced development severe skin lesions examined means depletion transfer results impaired conclusion murine model impaired skin barrier established study demonstrated critical role defective activities development severe skin lesions mice
present paper analyses effect self efficacy sports injury extent effect mediated coping strategies competitive situations shown athletes assessed regarding number injuries suffered last months general self efficacy coping strategies regression analysis proved two coping strategies emotional risk behavior predicted suffering less injuries respectively path analysis showed self efficacy directly related number injuries indirectly coping strategies unexpectedly greater self efficacy induces coping strategies oriented trying new options risky alternatives risk behavior coping strategies directed control negative emotions emotional related least risk taking behaviors former increasing later decreasing vulnerability sports injury
carbon dots got much attention recently considering environment protection green materials urgent paper nitrogen sulfur doped carbon dots prepared one simple convenient hydrothermal approach green leaves materials synthesized carbon dots successfully doped nitrogen sulfur elements fluorescence intensities carbon dots rather stable different ionic strength furthermore green successfully applied fluorescent probes due excellent optical properties low cytotoxicity elsevier rights reserved
accurate person perception crucial social decision making one central elements successful social perception ability understand response bias behavior represent different inner states depending whether people present study tried investigate internal biases others perceived using multi trial learning paradigm perceivers made predictions targets responses various suggested activities received feedback prediction trial trial hypotheses internal decision criterion targets realized repeated experiences due positive negative asymmetry recognized gradually probabilistic integration repeated experiences find neural evidence tracks probabilistic integration forming person knowledge response biases employed model based fmri state space model discovered person knowledge modulated several brain regions including nucleus hippocampus etc moreover person knowledge updated incorrect performance feedback brain regions including nucleus also involved overlapping regions processes nucleus suggesting regions take crucial roles forming person knowledge repeated feedback reflecting acquired information current prediction elsevier inc rights reserved
aim study investigated whether allergies among increased sweden whether geographical differences observed previous studies remained methods collected questionnaire data asthma allergic arc eczema children aged seven eight years south western sweden northern sweden regions questions used three studies extra questions food allergy intolerance added results total prevalence asthma arc eczema respectively asthma prevalence remained higher significant regional differences seen arc eczema almost reported history food allergy intolerance higher prevalence allergy risk reduced parents born outside sweden conclusion prevalence arc continued increase increases asthma eczema started level geographical differences remained total allergy rates similar
ecology different historical roots despite similar names slowly converging meet challenge addressing massive global proliferation release chemicals environment conceptual methodological review standard research papers special issue reflect emerging trend blending ecological perspectives assess impacts freshwater ecosystems assessing community ecosystem impacts chemical contaminants complex however require approaches explicitly consider biological chemical diversity natural variability environmental factors multiple spatial temporal scales central themes papers issue importance indirect effects chemical contaminants species interactions food effects multiple stressors especially interactions contaminants environmental factors iii consequences chemical exposure ecosystem processes primary production decomposition need account context dependency potentially harmful community ecosystem effects emerging contaminants among nanoparticles represented collectively papers show integrating ecological principles design implementation research essential assessing predicting contaminant impacts biological communities ecosystems conversely applied ecology benefit concepts approaches developed fully chemical contaminants key drivers community structure ecosystem processes
objectives schizophrenia accompanied impaired cortical inhibition measured several markers including cortical silent period thought measures gamma acid receptors gaba mediated inhibitory activity mutual roles schizophrenia disease drugs used treatment psychosis gaba mediated neurotransmission clear methods recruited drug naive patients first episode schizophrenia used transcranial magnetic stimulation assess prior initiating monotherapy four weeks later time rated severity psychopathology using positive negative syndrome scale results obtained data patients showed significant increase cohens treatment total score significantly lower individual however correlation found conclusion study patients first episode schizophrenia demonstrated association monotherapy increase gaba mediated inhibitory neurotransmission
study authors propose norm shrinkage linear least mean squares algorithm norm shrinkage widely linear least mean squares algorithm sparse system identification proposed algorithms exploit priori errors calculate varying step size thus adapt time varying channel meanwhile cost function introduce penalty term sparsity enable applicability sparse condition moreover algorithm also makes full use non circular properties signals interest improve tracking capability estimation performance quantitative analysis convergence behaviour algorithm verifies capabilities proposed algorithms simulation results show compared existing least mean squares type algorithms proposed algorithms perform better sparse channels faster convergence rate lower steady state error channel changes filter proposed algorithms adapt variation channel quickly
study aims introduce novel device mechanical pulse work synchronization serial communication technique used enable communication pulse value pulse rate read pulse transmitted mechanical transmitter receiver lines fuzzy logic based software developed mechanical values calculates percentage oxygen positive end pressure delivered patient fuzzy logic based software developed check changing medical states patients produce new results according new state values delivered patient calculated way without requiring arterial blood gas analysis experiments feed physicians show device makes possible obtain successful results compared current practices
work presents uncertainty quantification includes parametric inference along uncertainty propagation adsorption fiber complex dynamic chemical process parametric inference via bayesian approach performed using sequential monte carlo completely parallel algorithm predictions obtained propagating posterior distribution model presence residual variability observed data model often present significant challenge performing parametric inference work residual variability observed data handled three different approaches performing inference isolated data sets increasing uncertainty model parameters finally using model discrepancy term account uncertainty pros three approaches illustrated along predicted distributions breakthrough capacity scaled process american institute chemical engineers
aim evaluate quality accuracy websites written public inflammatory bowel disease ibd crohns disease ulcerative colitis assess level methods google search engines searched independently three researchers december english language websites selected basis predetermined inclusion exclusion criteria researchers independently evaluated quality website using instruments levels calculated using two formulas grade level index index agreement calculated using kappa coefficient results eighty four websites finally identified scores varied minimum score maximum mean median interquartile range interquartile range iqr minimum score maximum mean median iqr websites reviewed websites universities research centers foundations associations commercial pharmaceutical companies volunteer work non university educational bodies grade level score mean index score significant correlation found two scores overall agreement measured kappa coefficient range rated good conclusion scores websites varied levels websites public level study highlights areas need improvement development patient education online materials ibd
background recombinant human inhibitor demand treatment hereditary angioedema purified milk transgenic rabbits contains low amounts host related trigger hypersensitivity reactions patients rabbit allergy milk allergy objective study assessment safety patients methods patients underwent skin prick test test ict results negative subcutaneous challenge negative predictive value skin test protocol calculated defined ratio patients without systemic symptoms hypersensitivity following challenge number patients tested negative ict adverse events exposure recorded results twenty six patients enrolled twenty four negative ict results whereas negative result positive ict result highest concentration twenty two patients negative ict results underwent challenge none developed allergic symptoms local treatment emergent adverse events occurred patients challenge considered drug related mild conclusions none patients negative ict results allergic symptoms challenge negative predictive value combination ict outcome challenge administration tolerated
antimicrobial peptides produced living organisms play important role readily available non specific pathogenic microorganisms tomato short cationic peptide forms lethal pores microbes plant cells produced signal sequence targeting acidic region decrease toxicity producing organism gene expression analysis qrt pcr tomato plants demonstrated constitutively expressed mostly leaves fungal infection external application methyl operating dependent defense response systemic reaction elevated expression gene triggered parts tomato plants abiotic stress factors like extreme temperatures dehydration affect expression upon expression strongly enhanced tomato fruits furthermore provide evidence protein level bioactive also increased upon application methyl tomato seedlings elsevier gmbh rights reserved
extant literature established consistent association aspects reading motivation enjoyment self perceived ability reading achievement motivated readers generally skilled readers however developmental etiology relation yet investigated present study explores development motivation achievement association genetic environmental underpinnings applying cross lagged design sample twins examined relative contribution genetic environmental factors association reading enjoyment self perceived ability reading achievement children completed reading comprehension task self reported reading enjoyment perceived ability twice middle childhood years old results showed modest reciprocal association time reading motivation enjoyment perceived ability reading achievement reading motivation age statistically predicted development later achievement similarly reading achievement age predicted development later motivation reciprocal association observed beyond stability variables correlation largely explained genetic factors
smart environments learning considered new level computer enhanced learning number new interesting facilities famous group report started decade various research initiatives rapidly growing area ambient intelligence introduced also smart environment example form scenario scenario ambient social learning vision learning environment based position learning social process scenario certainly incentive number new initiatives focused less successful attempts design introduce various types smart environments capable support different aspects learning process multi agent systems frequently used approach towards smart environments design general really systematic approach towards reflecting desirable functionalities smart learning environments based designed multi agent architecture paper firstly map recent state art area smart environments designed learning wish list desirable functionalities smart environment learning propose multi agent architecture capable reflecting functionalities smart environment similar described mentioned scenario
negative parental attributions related parent family stressors thought important predictors subsequent disciplinary actions potentially abusive parenting examined negative parental attributions mediate relation daily stressors low ses parenting stress partner related stress parents history child maltreatment harsh abusive parenting mothers completed computerized attribution task reported daily stressors history child maltreatment discipline strategies mothers negative parental attributions mediated association parenting stress stressors harsh abusive discipline finding interventions decrease risk child abuse focus reducing abuse related stressors also target negative parental attributions elsevier ltd rights reserved
relationship religious psychological examined sample individuals treated drug abuse court mandated outpatient program three separate factors religious found exploratory factor analysis revised religious scale named true religion psychological individuals court mandated outpatient substance abuse treatment found correlated high levels religious psychological found related satisfaction services relationship found religious satisfaction services one factor religious found associated high levels depression hostility implications relationships treatment understanding religious psychological discussed
medical veterinary professional programs demanding impact students quality life qol aim study compare perceived qol two groups study used questionnaire higher scores mean better perceived qol students phase program selected compare two groups similar way total valid questionnaires gathered apart age body mass index bmi two groups similar scores five domains physical activity limitation due health problems usual role limitation due emotional problems vitality general mental health general health perception also total score statistically higher medical students score one domain social activity limitation due physical emotional problems statistically higher veterinary students bmi physical activity limitation due health problems vitality lost significance binomial logistic regression found general veterinary students lower scores perceived qol social function exception assumed medical students interaction human patients negative impact score domain even though medical students shown lower perceived qol general population previous studies veterinary students appear slightly lower perceived qol medical students
potential therapeutic targets immune inflammatory diseases studies aimed investigate safety tolerability profile selective inhibitor delta humans phase randomised double blind placebo controlled single centre studies evaluated single multiple oral doses bid healthy adults subjects mild moderate psoriasis study pharmacodynamic effects markers inflammation assessed via changes vivo histological assessment psoriatic skin biopsies tolerated doses study study days safety concerns dose limiting toxicities identified study incidence gastrointestinal related aes dose related higher incidences rash aes associated higher dose study rash aes treated subjects versus placebo treated subject mean plasma concentration time profiles increased increasing doses single multiple dosing major deviations dose unexpected accumulation loss exposure multiple dosing time independent pharmacokinetic profile apparent values supportive daily dosing geometric mean study study clinically significant food effect observed study pharmacodynamic findings demonstrated vivo inhibition improvements histological assessment skin biopsies markers psoriatic biology preliminary evidence target engagement psoriatic skin tissue safety tolerability pharmacokinetic pharmacodynamic profiles support continued clinical development immune inflammatory diseases
present study evaluated effectiveness adults children together act raising safe parenting program violence prevention developing country specific objectives following compare parenting practices according mothers perceptions pre post intervention compare child behavior problems resources according mothers caregivers perceptions pre post intervention participants brazilian mothers year old children another caregiver child included study second child behavior mothers participated act program pre post intervention evaluations primary caregiver participated two evaluations child behavior results showed parenting practices improved significantly pre post intervention mothers primary caregivers reported significant decrease child behavior problems pre post intervention regard total behavioral difficulties emotional symptoms peer relationship scales mothers also reported significant decrease scores conduct problems hyperactivity improvements child behavioral capabilities regard prosocial behavior conclusion improvements parenting practices child behavior observed act program elsevier ltd rights reserved
bond strength important factor electronic photonic packaging measuring bond characteristics strength fracture toughness particularly difficult devices miniaturized bonds used bonding dimensional integrated circuits since applying load directly bonds proven difficult four point bending test specimen typically used facilitate fracture toughness measurements small scale method based experiencing large shear stresses interface two layers different materials notch however lack analytical solution used determine shear stresses interface four point specimen manuscript presents analytical modeling shear stresses tri layer four point specimens strength materials approach assumption small strains within elastic region adopted study evaluation stresses displacements furthermore beam theory utilized develop equations describe moments shear forces assembly due four point bending loads second fourth order differential equations derived shear stresses respectively interfaces assembly boundary conditions determined based load supports shear force moment diagrams assembly problem solution obtained solving governing differential equations using standard methods finite element based simulation used compare verify analytical solution work also presents alternative approach stresses notch used determine fracture toughness experiment conducted specimen inter metallic material bond material analytical approach verified results four point bending experiment validated using conventional technique based energy equilibrium presented elsevier ltd rights reserved
exogenous bioactive compounds originate large extent anthropogenic activities although also naturally produced environment present study nine new authentic reference standards corresponding methyl ether derivatives characterised nmr spectroscopy mass spectrometry seven authentic reference standards prepared thereafter identified pooled human blood sample identified hydroxy ether hydroxy ether hydroxy ether hydroxy ether hydroxy ether hydroxy ether hydroxy ether additional seven identified pooled human blood sample one hydroxy ether identified human blood identification performed using gas chromatography mass spectrometry recording ions identification supported peaks relative retention times compared authentic references two columns different three different columns likely originate human metabolism flame due relatively high concentrations human blood sample fact form identified via metabolic direct via shift elsevier ltd rights reserved
paper aim analyze geographical temporal variability disease incidence spatio temporal count data excess end consider random effects zero poisson models investigate geographical temporal patterns disease incidence spatio temporal models employ autoregressive smoothing across spatial dimension spline smoothing temporal dimension proposed analysis complex models computationally difficult perspective hand advent markov chain monte carlo algorithm made bayesian analysis complex models computationally convenient recently developed data cloning method provides approach mixed models also computationally convenient propose use data cloning yields maximum likelihood estimation conduct analysis zero spatio temporal modeling disease incidence one advantages data cloning approach prediction corresponding standard errors prediction intervals smoothing disease incidence space time easily obtained illustrate approach using real dataset monthly children asthma visits hospital province canada period april march performance approach also evaluated simulation study
software product line set software systems domain share common features also significant variability feature model variability modeling artifact represents differences among software products respect variability relationships among features feature model along reference model developed domain engineering lifecycle concrete product family derived selecting features feature model referred configuration process reference model however feature model configuration task feature models consist large number features hard maintain many factors including technical limitations implementation costs stakeholders requirements expectations considered configuration process recognizing issues significant amount research efforts dedicated different aspects feature model configuration configuration process several approaches proposed alleviate feature model configuration challenges applying visualization interaction techniques however limited empirical insights available impact visualization interaction techniques feature model configuration process paper present set visualization interaction interventions representing feature models empirically validated measure impact proposed interventions empirical study conducted following principles control experiments software engineering applying known software quality standard iso variables investigated experiment results empirical study revealed employed visualization interaction interventions significantly improved completion time comprehension changing feature model configuration additionally according results proposed interventions easy use easy learn participants
continue explore scaling transformation reduced action formalism gravity models extension construction consider extended forms relation various black holes adopting constant bulk pressure literatures black holes firstly using quasi local formalism charges show general theory gravity volume black hole thermodynamics defined thermodynamic conjugate variable bulk pressure way first law extended consistently called thermodynamic volume expressed explicitly terms metric field variables using scaling transformation allowed reduced action formulation obtain extended relation involving bulk pressure thermodynamic volume approach homogeneous scaling charges incorporating contribution without difficulty
due massive parallel computing capability outstanding image signal processing performance cellular neural network cnn one promising type non boolean computing system outperform traditional digital logic computation mitigate physical scaling limit conventional cmos technology cnn originally implemented analog technologies operational amplifiers operational transconductance amplifiers neurons synapses respectively power area consuming paper propose hybrid structure implement cnn magnetic components cmos complete driving sensing circuitry addition propose digitally programmable magnetic synapse achieve positive negative values templates rigorous performance analyses comparisons optimal energy achieved based various design parameters including driving voltage cmos driving size comparable footprint area operation speed cnn projected achieve one order magnitude energy reduction per operation compared cmos counterpart
alcohol specific genetic factors genetic factors related externalizing behavior influence problematic alcohol use little known however role components genetic risk alcohol related behaviors across development prior studies conducted male cohort twins suggest externalizing genetic factors important predicting heavy alcohol use adolescence whereas alcohol specific genetic factors increase importance transition adulthood report studied twin twin pairs examine developmental trajectories investigate whether sex sex effects modify genetic influences methodswe used prospective longitudinal twin data collected ages within population based cohort study analytic dependent measures alcohol use behaviors included alcohol initiation age frequency ages alcohol dependence criteria age individuals genetic risk alcohol use disorders indexed parents dsm alcohol dependence criterion counts likewise individuals genetic risk externalizing disorders indexed composite measure parents dsm conduct disorder antisocial personality disorder criterion counts strongly related alcohol use behaviors adolescence strongly related alcohol problems young adulthood sex twin sex significantly moderated associations genetic risk alcohol use behaviors across development influenced early adolescent alcohol use behaviors females males influenced age males females addition associations frequency greater among year old females twin found divergent developmental trajectories alcohol specific externalizing behavior related genetic influences alcohol use behaviors early adolescence genetic influences alcohol use behaviors largely nonspecific later adolescence young adulthood alcohol specific genetic influences alcohol use influential importantly within overall trajectories several interesting sex differences emerged found relationship genetic risk problematic drinking across development moderated individuals sex sex influenced adolescent alcohol outcomes females males age influenced criteria males females addition association genetic risk frequency greater among year old females male
background avian pathogenic coli lead loss millions poultry annually mortality produce contamination studies verified many immune related genes undergo changes alternative splicing along mediated decay regulate immune system different conditions therefore splicing profiles primary lymphoid tissues systemic infection need comprehensively examined results gene expression data obtained three different immune tissues bone marrow thymus three phenotype birds non challenged resistant susceptible birds two time points alternative splice sites exon inclusion identified major alternative splicing events avian primary immune organs systemic infection study detected hundreds transcript containing genes different phenotype birds days post infection important functions systemic infection transcription start sites indicate cell death cell cycle cellular function maintenance predominant host systemic conclusions use technology bioinformatics tools study provides event primary lymphoid tissues play critical roles host homeostasis systemic infection according study plays pivotal regulatory role immune response chicken systemic infection via either alternative study regulatory role immune complex systemic infection
aim investigate serum mean platelet volume levels acute patients assess whether effectively predicts disease severity methods included consecutive patients group consecutive patients colorectal endoscopic treatment control group complete blood counts liver function platelet indices coagulation parameters lactate dehydrogenase ldh reactive protein crp measured days admission receiver operating characteristic curves used compare sensitivity specificity white blood cell ldh crp predicting severity modified prognostic score revised criteria used evaluate disease severity results levels significantly lower group control group day day day admission addition values lower day admission day day day patients based patients diagnosed mild patients severe significant difference mean levels patients diagnosed mild severe based according revised criteria patients without persistent organ failure non severe acute non group patients persistent group levels significantly lower group non group day admission day admission using cut value overall accuracy predicting according revised criteria auc sensitivity specificity superior accuracy traditional markers auc ldh auc conclusion used additional cost useful noninvasive biomarker distinguishes persistent without persistent day hospital admission
order reduce stress fuel cell based hybrid source fed electric drive system controller design made active current sharing technique effectiveness proposed technique tested drive system fed fuel cell battery energy sources enables load current sharing source power management high efficiency reliability hybrid system achieved proper energy conversion management power meet load demand terms required voltage current overcome slow dynamics feature battery bank adequate power capacity incorporated voltage drops heavily fast load demand controller allows fuel cell operate normal load region draw excess power battery order demonstrate performance drive using control strategy different modes operation hybrid source static dynamic behavior control system verified simulation experimental results control scheme implemented digitally labview interface card efficacy controller performance demonstrated system changing condition supplemented experimental validation elsevier ltd rights reserved
wave theories heating solar wind due fluctuations strengthened existence wave observed transition region intensity oscillations solar explored using solar optical increasing height solar limb active region used time sequences near south east region line obtained april applied procedure illustrate effectively restoration method works fine structures moreover intensity oscillations different heights solar limb analysed wavelet transforms afterwards phase difference measured oscillations two heights search evidence coherent oscillations results wavelet transformations revealed dominant period peaks min four separate heights dominant frequencies level higher per cent found around mhz mean phase speeds measured found mean phase speeds increased height results suggest energy flux carried coherent waves several times larger previous estimates based solely constant velocities provide compelling evidence existence propagating coherent waves
base methylene complexes synthesized compounds characterized different physico chemical spectroscopic tools vis nmr mass molecular structure determined single crystal ray diffraction technique ligand displays configuration bond structure ligand stabilized intra molecular bonding metal complexes ligand coordinates carbonyl resulting distorted geometry complexes chloride ions axial positions complexes however form coordinate distorted square geometry around metal ion respectively structures complexes satisfactorily modeled calculations based density functional theory dft time dependent dft dft corrosion inhibition study compounds performed mild steel solution using weight loss polarization electrochemical impedance spectroscopy eis show corrosion inhibition property elsevier rights reserved
memory one way past becomes powerful agent present today sites become sites memory healing response rapid spread hiv aids paper concentrates one site local community practiced healing way restore spiritual balance set narratives integrate ethnographic interviews one former russia article trajectory perceived power active role complex web morality practicality alternative narratives emerge time social disruption later fall apart paper others issue focusing memory place time material culture engaged process includes formal accepted marginal even viewpoints holds lessons approach past
simple methods fabricate devices using regular paper substrate sensors able detect ultraviolet visible infrared radiation using different paper additives experiment made test detection ultraviolet visible light consists light different wavelengths device made paper semiconductor crystals electrical current devices increases importantly energy semiconductor crystal reached test sensitivity infrared use paper devices glycerol increment electrical conductivity due augmentation ionic current carriers observe ionic conductivity paper increases paper irradiated infrared light hot objects phenomenon due molecular structure cellulose energy infrared part spectrum
microwave wave analog signal processing asp novel paradigm great promise microwave wave systems authors group done intensive research area past years presents overview results cover technologies synthesis techniques various applications
enhanced asymmetric color image proposed using equal modulus decomposition transform domains scheme performed create effective one way function moreover enhance security mapping considered utilized rgb components color image parameters mapping transform served extra keys entire various types attacks considered robustness analysis experiments numerical simulations made verify validity capability proposed color encryption algorithm
increases drug partitioning surface skin diffusion drugs skin lipid stratum alters arranged lipid structure intercellular lipids however solid room temperature difficult determine effects alone study order avoid effects solvents applied stratum lipid models comprising composed longest lipid acyl chain stratum lipids associated barrier function skin shorter lipid acyl chain components stratum intercellular lipids associated water retention intercellular lipid structure stratum cholesterol acid ray diffraction differential scanning calorimetry attenuated total reflection fourier transform infrared spectroscopy analyses revealed lipid models composed hexagonal structures different periods taken together results revealed strongly affected lipid model composed therefore facilitated drugs skin liquid longer structure importantly simple lipid models useful investigating microstructure intercellular lipids stratum
organic rankine cycles nowadays valuable technology produce electricity low medium temperature heat sources biomass waste heat recovery applications dynamic simulations help improve flexibility operation plants guarantee better economic performance work dynamic model multi pass power plant developed dynamics validated measured data model combines finite volume approach tube side two volume cavity side validate dynamic model positive negative step function heat source flow rate applied simulation model performed cases liquid level appeared challenging quantity simulate better agreement temperature achieved increasing volume flow rate entire simulation measurement errors discrepancies working fluid thermal properties uncertainties heat transfer correlations account future entire power plant simulated suggestions improve dynamics control means simulations provided
paper presents novel implementation gpu computing boundary element method formulation plates new gpu code written cuda alters three kernels calculation influence matrices solution equations computation internal values comparisons computation time different gpu architecture presented formulation implemented constant quadratic elements efficiency parallel quadratic code demonstrated via analysis practical building benefits parallel computing solution system equations points inside domain discussed
research fungal pathogens aim identify virulence determinants strictly relies generation defined recombinant strains task executed means sophisticated molecular biology toolbox recent developments fungal genome engineering opened new implementing technology based expression loaded single guiding rna molecule target defined site recipient genome novel approach adapted successfully engineer fungal genomes among one human pathogenic aspergillus implementation required components achieved various means differ respect expression enzyme delivery validation mediated mutagenesis executed targeting selected candidate genes provide promising perspective screening approaches opportunistic fungal pathogen comprehensive manner analyzing genetic polymorphisms function gene families
objectives union popular sport high injury risk burden injury described incidence severity injury however reports ignored monetary cost injuries therefore aim study describe monetary cost associated youth injuries design descriptive study quantified medical treatments injured players south african union youth days work parents missed result injuries health used data calculate associated costs methods legal injured players contacted weekly basis returned play treatments costs estimated south african based insurance rates converted using power results players sought medical care players average treatment costs high per player fractures expensive type injury players medical insurance higher costs without conclusions although minority players sought follow treatment cost injuries high players without medical insurance lower costs indicate players receive adequate treatment injuries injury prevention efforts consider injuries high costs treatment players without medical insurance sports medicine australia published elsevier ltd rights reserved
patient demand aesthetic steadily growing free metal evolved attempt overcome nature full although many different materials used making single material fits best purposes two groups ceramic material one group laboratory composite group diameter thickness prepared according manufacturers instruction surface ceramic group liquid primer applied composite surfaces thirty extracted sound human randomly divided three groups surface tooth slightly side primed prepared aid dental specimens degrees degrees cycles prepared shear bond strength testing resulting data analyzed one way anova test surfaces specimen means sem significant difference bond strength materials tested mean bond strengths obtained ceramic mpa mpa mpa respectively fracture pattern mainly mixed ceramic groups scientific evidence needed standardization bonding protocols
body image primary school body image curriculum widely available yet evaluated study evaluates set available lessons curriculum seventy four girls boys aged recruited four primary schools schools randomly allocated intervention condition students received hours body image lessons lessons normal body esteem significantly higher among girls intervention group compared control group immediately post intervention month follow moreover girls lowest levels body esteem baseline reported largest gains internalization significantly lower among boys control group compared intervention group month follow pattern results among control group raises interesting issues intervention evaluation published elsevier ltd
background clinical utility serum igg measurement diagnosis allergy food induced hypersensitivity largely recent studies however shown specific igg inhibit ige mediated allergies play role allergen specific desensitization accurate reference intervals igg specific allergens widely established needed better interpretation serum antibody concentrations study established igg reference intervals common food allergens design specific igg concentrations determined employing automated fluorescent enzyme immunoassay serum samples normal adults males females age range mean results lower reference interval limit allergens tested median upper reference interval value allergens lowest upper interval limit demonstrating highest upper interval limit conclusions considerable variation observed among upper reference interval limits emphasizes need establishment allergen specific ranges igg newly established ranges useful aid clinicians interpretation laboratory serum igg results
paper proposes novel high speed visual target tracking system based mixed rotation invariant description searching method novel rotation invariant description texture edge information dominant direction overcomes rotation variant large computation issues conventional feature description searching method used tracking remarkably decrease computation time avoiding repeated searching operations proposed tracking system contains image sensor hierarchical vision processor actuator dimensions freedom dof vision processor integrates processors pixel row level parallelism speed tracking algorithm experiment results show proposed system achieve processing speed tracking algorithm resolution image
slope instability due rainwater infiltration poses serious problem causes thousands deaths severe damage infrastructures year present study effect inclusion hybrid geosynthetic layers within slope subjected rainfall investigated numerically analysis done without hybrid geosynthetic layers embedded sand slope inclination rainfall intensities ranging rainfall simulated numerically deformation stability analyses performed onset rainfall rainfall rainfall need drainage reinforcement function reinforced slope highlighted analysing effect geotextile geogrid layer inclusions separately slope subjected rainfall results indicate inclusion hybrid geosynthetic layers effective lowered surface causing reduction excess pore water pressure static global stability hybrid geosynthetic reinforced slope found increase considerably intensities rainfall deformation values significantly lower reinforced slope compared unreinforced slope
development human eye requires coordinated interplay cells different origins optic origin derives neural tube gives rise neuronal retina retinal epithelium epithelial layers body lens optic development surface cells neural crest provide ocular ocular blood vessels origin basic processes eye development completed end second month embryonic life however correct functioning maturation processes required completed birth several months examples aqueous circulation maturation optic nerve completion retinal vasculature
meta analysis average estimates multiple parameters treatments effect multiple outcomes across studies univariate meta analysis considers parameter individually multivariate meta analysis considers parameters jointly accounts correlation estimates performance extensively compared scenarios two parameters objective compare performance number parameters increases specifically show fixed effect meta analysis benefit using substantially increase increases random effects meta analysis benefit increase increases potential improvement modest presence high study variability actual improvement reduced need estimate increasingly large study covariance matrix iii little study variability loss efficiency due choosing increases increases demonstrate three features theory simulation meta analysis risk factors non hodgkin lymphoma
objective study explored compared attitudes student groups trained university dental academy towards dental education methods study population consisted fifth year student college london dental institute second third year dental hygiene therapy first year dental nursing students item validated modified questionnaire readiness inter professional learning scale administered contains three subscales teamwork collaboration professional identity roles responsibilities mean bar standard deviation scores calculated following reversal negative items analyses carried using spss version version results overall response rate achieved reference teamwork collaboration groups strongly indicated contribute learning teamwork skills bar improving relationships team members bar however scores differ groups respectively concerning professional identity student significantly higher preference discipline based approach likely agree necessary undergraduate dental dental care professional students learn together perceived clinical problem solving skills effectively students discipline dental hygiene therapy students relation roles responsibilities participants demonstrated strong sense professional role student reported gain knowledge skills dental hygiene therapy dental nursing students dental hygiene therapy students less likely student agree role dental nurses mainly provide support conclusion findings suggest perceived beneficial relation teamwork however study raises issues regarding professional identity roles educators consider differing perceptions professional roles identities planning delivering programmes
studies whether family history venous thromboembolism affects long term mortality missing aim study determine whether affects long term mortality first episode using swedish medical databases conducted year nationwide cohort study adult swedish born patients included multi generation register born later first time using cox regression assessed mortality hazard ratios hrs confidence intervals cis totally patients first degree parent patients without significantly risk factors comorbidities mortality first years first time decreased compared without crude adjusted years follow significant effect mortality crude adjusted cancer associated mortality common without first years years difference cancer associated mortality results suggest patients lower thrombotic threshold need less factors comorbidities also slightly lower total cancer mortality first years
background previous association studies identified number putative risk loci alcohol dependence however loci replicated replicated variants explain small proportion risk using innovative approach goal study generate hypotheses potentially causal variants explored functional studies methods employed targeted capture candidate loci flanking regions followed next generation deep sequencing mean coverage european americans regions included targeted capture library genes identified published gwas alcohol human alcohol reward system genes including dopaminergic opioid receptors prioritized candidate genes based previous associations genes involved absorption distribution metabolism excretion drugs performed single locus tests determine single variant associated symptom count sets variants overlapped biologically meaningful annotations tested association aggregate results single common variant significantly associated study however find evidence association several variant sets two variant sets significant value level enhancer alcohol dehydrogenase adenosine receptor belongs protein coupled receptor gene family conclusions knowledge first sequencing study examine variants entire genes including flanking regulatory regions found addition protein coding variant sets regulatory variant sets play role findings generated initial functional hypotheses sets influence
laminar boundary layer flow heat transfer non newtonian fluid inclined solar collector plate presence thermal hydrodynamic slip conditions analysed inclined plate surface maintained constant temperature boundary layer conservation equations parabolic nature normalized non similar form solved numerically tested efficient implicit stable box finite difference scheme increasing velocity slip induces acceleration flow near inclined plate surface increasing velocity slip consistently enhances temperatures throughout boundary layer regime increase thermal slip parameter strongly flow also reduces temperatures boundary layer regime increase rheological parameter acts considerably velocity effect pronounced higher values coordinate temperatures however slightly decreased increasing values rheological parameter
increases plant cover environments reported globally years generally perceived threat productivity biodiversity despite attempts made estimate extent increase national scale principally due technical constraints availability appropriate remote sensing products study aimed measure extent replaced south use landsat data conjunction satellite band radar data estimate extent method employed allows unique nationwide measurement transitions classes recent decades estimate year study period replaced similar conversely replaced similar net increase extent similar annual increase changes varied markedly across country areas receiving mean annual precipitation showed higher rates expansion regions change map presented provides unique opportunity test numerous models plant national regional scale
cleavage rate limiting step decay containing human beta mrna erythroid cells truncated intermediates thus generated stable parent mrna northern blotting commonly used measure decay rate full length mrna protection used assay fate decay intermediates adapted sensitive facile assay nucleic acids res quantitatively monitor decay process detecting full length beta decay intermediates
diabetic state serious life threatening diabetes common young people type diabetes adult elderly patients type diabetes features disorders coexist characterized severe hyperglycemia early diagnosis management paramount treatment aggressive insulin therapy electrolyte replacement treatment underlying events article reviews epidemiology pathogenesis diagnosis management
paper presents power management system household photovoltaic battery hybrid power system within demand side management time use electricity system easy implement employing cheap electrical switches shelf inverters control system models combining power level home scheduling level proposed minimize residents energy cost energy consumption grid practical constraints strictly satisfied addition resident comfort level considered control system models trade among operating cost energy consumption considered multi objective optimization problem formulated optimal control strategies derived solving mixed integer nonlinear programming problem simulation results show energy cost energy consumption grid largely reduced proposed strategies results important customers major uncertainty determining whether newly install update photovoltaic battery hybrid power systems elsevier ltd rights reserved
numerical model piston dynamics analysis proposed coupling model piston liner system dynamics model system consisting connecting rod piston model solved finite element method dynamics equations established constraint matrix validation method verified comparing known existing work apart design parameters piston investigated reveal influence noise performances piston elsevier ltd rights reserved
paper investigate presence general purpose operating system influences reliability modern embedded systems chips experimentally study difference neutron induced error rate executing application bare metal without underlying operating system top linux kernel analysis demonstrates linux presence affects silent data rate whereas greatly increases system functional interruption rate times preventive measures taken nevertheless experimentally demonstrate cache conflicts operating system application significantly reduce linux induced rate increase moreover evaluate software stack effect show higher abstraction layer application implemented lower rate furthermore analyze system reliability taking account resulting failure rates also execution thus exposure times
micrornas emerged important cancer biology mir conserved mirna investigated detail reported induced hypoxia inducible factor hif alpha action progression breast hepatic pancreatic cancer however effects mir progression lung cancer subject debate present study found expression mir significantly upregulated non small cell lung cancer nsclc cells patients vivo however levels mir remained unchanged nsclc cell lines compared level normal lung cell line however levels markedly upregulated nsclc cell lines conditions chronic hypoxia subsequently mir mimic transfected nsclc cell lines examine effect progression nsclc cells vitro data obtained using mtt cell counting kit assays revealed mir effect proliferation cells normal condition however proliferation promoted mild hypoxic conditions addition results transwell migration assay showed mir promoting effect nsclc cell migration conditions chronic hypoxia furthermore bioinformatics server untranslated region luciferase reporter assay indicated transcription factor nuclear factor alpha target mir subsequent western blot analysis showed chronic hypoxia protein levels tumor suppressor enhancer binding protein sharply reduced cells conclusion mir induced chronic hypoxia promoted proliferation migration nsclc cells chronic hypoxic conditions promotion associated targeting present findings provide potential molecular target therapeutic treatment nsclc
agreement client therapist essential part therapeutic alliance general challenges creation agreement shared meaning specific challenges working persons psychosis challenges include different narratives client therapist regard roles description condition problem possible views theoretical bias present metacognitive model framework understanding resolutions challenges copyright john wiley sons ltd
evolution concept child abuse leads consider new types maltreatment future certainly taken account new era social pediatrics pediatric care based increased awareness importance meeting psychosocial developmental needs children role families promoting health
aluminum doped zinc oxide attained intensive attention good transparent conducting oxide photovoltaic applications work films deposited glass substrate radio frequency influences substrate temperatures morphological structural optical electrical properties films systematically investigated results indicate films hexagonal structure axis preferred orientation morphological electrical measurements revealed substrate temperatures strong influence microstructure optical electrical properties films film highly transparent ultraviolet near infrared range highest average transparency exceeding minimum low omega carrier concentration mobility high respectively finally performances film evaluated practical application photovoltaic device transparent electrode benefited highly transparent conductive feature efficient device reveals efficiency short circuit current density open circuit voltage fill factor standard conditions elsevier rights reserved
single image super resolution great importance computer vision various methods learning methods successfully developed recent years despite demonstrated success natural images less research focuses infrared images paper present transformed self similarity based super resolution method without learning restore high resolution infrared images low resolution ones exploit appearance similarity dense error region use detected cues guide patch search process also add scale cue consider local scale variations present framework simultaneously accommodate four different cues experimental results demonstrate method performs better previous methods results high evaluate scores show effectiveness robustness method infrared images elsevier rights reserved
rheumatoid arthritis chronic autoimmune disease characterized joint destruction caused infiltrating leukocytes including cells important role cell stimulation played signal transducer inhibitory produced circulating cells plays active role activity cells aim study examine associations polymorphisms within genes examined patients female male mean age years rheumatoid arthritis healthy subjects female male disease activity determined basis score patients classified subjects active form statistically significant differences distribution studied genotypes alleles patients control group statistically significant difference observed distribution exon genotypes patients increased frequency genotype among patients revealed results study suggest significant association exon gene polymorphisms polish population results indicate possible association exon gene polymorphism activity
time varying flow studied experimentally accurate model human airways mouth several generations bronchial airway geometry obtained scan healthy adult male normal height build three component three dimensional mean velocity field obtained throughout entire model using phase locked magnetic resonance velocimetry pump drives sinusoidal waveform inhalation frequency stroke length mean reynolds number peak number integral parameters defined quantify degree velocity profile non uniformity related axial dispersion secondary flow strength lateral dispersion found airways significantly modify flow flow first bifurcation highly asymmetric effect flow oscillation produce time dependent flow features asymmetric respect acceleration periods surrounding peak inhalation pronounced regions separation secondary flow structure sensitive local attributes real anatomy reflected integral parameters behave non successive bronchial generations general measured oscillatory flow realistic anatomy confirms many trends derived models also possesses qualitatively different large scale flow structures compared representations upper airways elsevier inc rights reserved
clinical observation suggests important overlap borderline personality disorder bpd autism spectrum disorders given background aim study investigate autistic traits patients borderline personality disorder special attention cognitive empathy women borderline personality disorder participated autistic traits assessed autism spectrum quotient facets empathy interpersonal reactivity index scale results show almost half bpd patients scored beyond cut subgroup high autistic traits lower scores cognitive empathy higher scores implications clinicians discussed
background model widely used promote healthy behaviors different groups however questionnaire yet developed evaluate health behaviors medical practitioners often consider individuals cancer high risk developing cancer purpose aim study construct validate health behavior stages change questionnaire based health recommendations related risk factors protect cancer methods content validity conducted two phases qualitative quantitative item difficulty index item discrimination index discrimination coefficient obtained based classical test theory finally cronbachs alpha used results measure concordance showed scores considered adequate excellent item discrimination index obtained rating excellent suggested preservation items discrimination coefficient scores global internal consistency specification groups internal consistency sample men sample women conclusion implications practice represents proposal fast simple innovative screening test aims identify persons benefit interventions promote health behaviors stage change
research characterized vibration responses cement pavement surface different moving vehicle load via laboratory simulated vibration response tests field tests done help micro seismic monitoring system laboratory simulated vibration response tests used impose impact loading geotextile rubber sheet used laboratory test results indicated impact load compared surface without vector sum peak vibration velocity surface rubber sheet single layered geotextile double layered geotextile decreased respectively vector sum maximum displacement amplitude decreased respectively field tests vibration response done estimated vehicle loading loading estimated vehicle speed surface geotextile plastic membrane tested field test results indicated conditions compared surface without vector sum peak vibration velocity surface double layered geotextile plus single layered plastic membrane single layered geotextile plus single layered plastic membrane single layered plastic membrane decreased respectively vector sum maximum displacement amplitude decreased respectively conclude rubber sheet geotextile help cement pavement surface significantly vibrations caused moving vehicle load impact load
patients hematological cancer high risk invasive fungal diseases infections mostly life threatening early diagnosis initiation appropriate antifungal therapy essential clinical outcome commonly aspergillus candida species involved however non aspergillus increasingly identified cases documented important risk factors long lasting neutrophil counts days graft versus host disease resulting allogeneic stem cell transplantation definite diagnosis various diagnostic tools applied including conventional culture microbiological tests antibody antigen molecular tests histopathology radiology last years various laboratory methods like aspergillus immunoassay aspergillus assay polymerase chain reaction pcr techniques developed better diagnosis since single indirect test including radiological methods provides definite diagnosis invasive fungal infection combination different diagnostic procedures include microbiological cultures histological serological molecular methods like pcr together pattern clinical presentation currently best strategy prompt diagnosis initiation monitoring early start antifungal therapy mandatory clinical diagnostics often provide clear evidence integrated care pathways proposed management therapy either diagnostic driven strategy using antifungal therapy opposed clinical empirical driven strategy using traditional empirical antifungal therapy antifungal agents preferentially used systemic therapy invasive fungal infections amphotericin preparations recently clinical decision making consider licensing status local experience availability pharmacological economic aspects
group identification predicts adherence groups norms values beliefs behaviors ability accurately perceive degree group identification important predicting others beliefs actions two studies examine friends accuracy bias rating identification social categories friends asked rate one identification state studies national global study social identities across studies friends shown accurate biased rating one identification thus although friends project identification onto bias friends also able accurately predict one degree connection social groups furthermore friends greater frequency contact found increase accuracy prediction together results provide initial evidence future research examining person perception intergroup interactions
important problem field bioinformatics identify interactive effects among variables outcome prediction paper logistic regression model pairwise interactions among set binary covariates considered modeling structure interactions graph goal recover interaction graph independently distributed samples covariates outcome viewed feature selection problem simple quantity called influence proposed measure marginal effects interaction terms outcome case underlying interaction graph known shown simple algorithm based maximum weight spanning tree respect plug estimates influences strong theoretical performance guarantees also outperform generic feature selection algorithms recovering interaction graph samples covariates outcome results also extended model includes individual effects pairwise interactions via help auxiliary
despite advances molecular biology imaging treatment gastric neoplasms remain significant cause morbidity mortality gastric adenocarcinoma fifth common malignancy third common cause death worldwide methods mol gastric cancer cancer incidence mortality worldwide internet international agency research cancer frequency malignant gastric tumors occur worldwide impact gastric neoplasms remain important lesions identify characterize imaging modalities despite varied behaviors neoplasms many similar imaging features nonetheless treatment management prognosis gastric neoplasms vary pathology essential make every effort differentiate lesions raise less common entities differential diagnostic considerations appropriate
purpose chronic illness low levels health literacy affect health outcomes many individuals particularly older adults racial ethnic minorities study sought understand knowledge strengths areas need regarding self management chronic illness order lay content development intervention increase health literacy maximize patient engagement chronic disease self care patients methods depth qualitative interviews conducted spanish english older adults various chronic illnesses topics included knowledge understanding chronic conditions medications disease self management skills qualitative data coded searching text conducting cross case analysis inductive analysis employed allow patterns themes emerge results emerged themes included social support coping strategies chronic disease health literacy anger depression participants general overall knowledge chronic illness deficits knowledge regarding illnesses medications conclusion chronic illness self management complex dynamic behavioral process study identified themes leverage patient motivation engage self care personalized manner information guide development intervention promote health literacy optimal disease self management
current image processing techniques capture large vessels reliably often fail preserve connectivity small vessels imaging artifacts noise create gaps intensity hinders segmentation vascular trees however topological analysis vascular trees require proper connectivity without gaps loops segments proper tree connectivity also important high quality rendering surface meshes scientific printing present fully automated vessel enhancement pipeline automated parameter settings vessel enhancement tree like structures imaging sources including rotational angiography magnetic resonance angiography magnetic resonance computed tomography angiography output filter pipeline vessel enhanced image ideal generating anatomical consistent network representations cerebral topological statistical analysis filter pipeline computational modeling potentially improve computer aided diagnosis cerebrovascular diseases delivering anatomy vasculature serve first step fully automatic epidemiological analysis large clinical datasets automatic analysis enable rigorous statistical comparison subject specific vascular trees robust accurate image segmentation using validated filter pipeline also eliminate operator dependency observed manual segmentation moreover manual segmentation time given vascular trees thousands segments interactive segmentation consumes excessive human resources subject specific trees first step toward patient specific hemodynamic simulations assessing treatment outcomes
background bipolar disorder commonly associated cognitive functional impairments even remission periods although growing number studies demonstrated benefits psychotherapy add pharmacological treatment effectiveness appears less compelling severe presentations disorder new interventions attempted improve cognitive functioning patients results mixed methods study consists clinical trial comparing new structured group intervention called rehabilitation treatment usual tau bipolar patients new approach combination cognitive behavioral strategies cognitive remediation exercises consisting weekly group sessions min included study patients diagnosed type aged years full partial remission least comprehensive neuropsychological battery followed mood social functioning quality life assessments occur three moments pre post intervention months later primary outcome study compare time weeks first full mood episode appears patients participated either group study secondary outcome include improvement cognitive functions discussion first controlled trial assessing validity effectiveness new cognitive behavioral rehabilitation intervention preventing new mood episodes improving cognitive functional impairments
background aim assess variability spontaneous rate without support methods forty eight healthy non contact lens aged years five minute video recordings made ambient lighting directing gaze distant target head height half subjects group resting head rest half group first analysed detail results assessed five minutes per min average per min initial average values calculated inter intervals averaged per minute group per minute group significantly different statistically significant decrease observed initial group variability values assessed successive coefficient variation values per cent respectively conclusions averaged spontaneous rates short time periods five minutes suitable compare various experimental paradigms short periods used example one minute less significant time related changes especially subject support
difficult extend morphological approach color images total vector ordering required color pixels address issue developed kind vector ordering method based linear transformations rgb color spaces principal component analysis pca additionally propose invariant morphological framework based proposed vector ordering also define elementary multivariate morphological operators multivariate erosion dilation opening closing investigate properties focus proposed framework guarantees important properties classical mathematical morphology translation invariance conditional therefore easy extend existing morphological approaches color images terms proposed multivariate morphological framework simulation results show potential abilities color image processing image filtering reconstruction segmentation elsevier inc rights reserved
aim review article examine solutions challenges associated bonded fibre reinforced polymer pipe sections materials used systems years higher specific mechanical properties corrosion resistance makes potential candidate replacing metallic structures another advantage structures large number design variables available despite advantages associated structures application still limited partly due unsatisfactory methods joining composite inadequate knowledge failure mechanisms different loading conditions bonded joints attractive many applications since offer integrated minimal part count require pipe extremities complex geometries threads bell configurations normally adhesive joint results uniform stress distribution fibre architecture smooth surface present article comprehensive review various joining techniques adhesive bonding presented damage mechanisms different loading conditions examined elsevier ltd rights reserved
computational studies effect interfaces phase grain boundaries materials mechanical properties strength materials potential interface enhance materials properties reviewed several groups materials composites nanocomposites metals wood considered view effect nanostructured interfaces properties structures various nanostructured interfaces protein structures mineral bridges wood pores nanoparticles fiber matrix interfaces polymer fiber reinforced composites nanocomposites dislocations grain boundaries metals methods modeling discussed concluded interfaces phase boundaries powerful tool controlling material deformation strength behavior allows enhance mechanical properties strength materials heterogeneous interfaces low stiffness leading localization deformation oriented normally main reinforcing elements ensure highest damage resistance materials elsevier ltd rights reserved
objective order increase classification accuracy tea category identification system paper proposed novel approach method proposed methods first extracted color histogram obtain color information wavelet packet entropy obtain texture information aim reducing features principal component analysis reduced features used input generalized eigenvalue proximal support vector machine takes used handle problem two kernels tested linear kernel radial basis function kernel ten fold stratified cross validation technique used estimate sample errors named method result results showed pca reduced features merely five explaining total variance recall rate achieved highest overall recall rate conclusion higher result five state art algorithms back propagation neural network support vector machine genetic neural network linear discriminant analysis fitness scaling chaotic artificial colony artificial neural network
inflammatory bowel diseases chronic diseases result inflammation intestinal wall suspected patient presenting intestinal symptoms recently diagnosis mainly based clinical endoscopic arguments use easy fast reliable non invasive inexpensive biological assay mandatory diagnosis also evolutionary therapeutic monitoring date fecal documented perspective marker allows discrimination functional organic bowel processes good performance determination fecal level contributes evaluation degree disease activity monitoring therapeutic response
recent years pso algorithm one popular soft computing technique increasingly used optimizing parameters pid controller however pso optimization algorithm general successfully used solve optimization problems validation functionality done earlier paper proposed functionality validation pso algorithm focusing fitness functions convergence particles due existence dimensional dimensional pid dimensional controllers functionality validation done dimensional problems test functions used experimental results shows proposed pso algorithm coded lab successfully proven fit employed optimizing dimensional problems later used optimize pid controllers variants dimensions problems
background probiotic supplementation women pregnancy lactation modulate breast milk composition immune benefits transferred infants aim aim study evaluate effect high dose probiotic supplementation women late pregnancy lactation cytokine profile secretory iga breast milk thus study differences breast milk composition affect levels stool samples newborns safety maternal probiotic administration neonatal growth pattern gastrointestinal symptoms also evaluated methods double blind placebo controlled randomized trial women took either probiotic placebo daily levels beta transforming growth factor beta tgf beta breast milk level newborn stool samples analyzed birth one month life evaluation analysis gastrointestinal events newborns also performed results probiotic maternal consumption significant impact mean values tgf beta mean values mature breast milk fecal mean values higher newborns whose mothers took probiotic product control group probiotic maternal supplementation seems decrease incidence infants conclusion high dose multi strain probiotic administration women pregnancy influences breast milk cytokines pattern production newborns seems improve gastrointestinal functional symptoms infants
light fact number elderly citizens society steadily increasing search dietary factors prolong mental growing significance coffee together main ingredient caffeine focus much attention various researchers data beneficial effects human health continue accumulate reports indicate moderate coffee consumption fact lower risk common neurodegenerative conditions alzheimers parkinsons diseases regardless due complex pathogenesis methodology scientific research exact impact coffee consumption remains fully elucidated present seems safe inform general public coffee need fear health possibly future experts recommend drinking coffee satisfy individual taste preferences also decrease age related mental deterioration
plug electric vehicles one clean technologies many advantages overcome problems power systems instance voltage distribution networks considering coordinated charging method voltage factor improved worsened real applications connected residential commercial networks form single phase charged discharged leads voltage paper effect network voltage investigated form optimization problem minimized objective function different conditions subject network security constraints using pso algorithm minimized optimally selecting state charging point connection phase charging rating power also impact coordinated charging evaluated besides effectiveness proposed framework studied based unbalanced three phase distribution network finally obtained results show coordinated charging significantly improve value published elsevier ltd
nitric oxide associated insulin resistance type diabetes mellitus association suggested single nucleotide polymorphism variant endothelial nitric oxide synthase gene increased risk however role polymorphism investigated hypogonadism low testosterone obesity believed play major role aimed evaluate whether gene single nucleotide polymorphism variant give relevant contribution also onset hypogonadism associated men affected late onset hypogonadism retrospectively reviewed patients clinically evaluated detection polymorphism performed splitting sample according three genetic variants difference evident age body mass index bmi total testosterone conversely prevalence significantly higher logistic regression analysis showed adjustment age bmi total testosterone positively significantly associated study suggests single nucleotide polymorphism gene independent risk factor hypogonadism associated type
syndrome silver syndrome growth disorders opposing affecting center tumor risk caused aberrant expression expressed gene occurring consequence mosaic within center mosaic paternal characterized severe intrauterine growth retardation subset cases recently shown mosaic within center predicted expressed early development molecular diagnosis involves methylation analysis locus enabling discrimination allelic methylation patterns study methylation sensitive high resolution melting analysis used analyze methylation within region locus total samples comprising normal control six dna analyzed blinded study scored normal results compared derived methylation sensitive southern blotting using restriction enzymes hpa total concordance obtained southern blotting scores total three samples paternal duplication affecting region scored methods however samples scored normally methylated using conclude rapid cost effective sensitive method screening mosaic methylation changes locus wiley liss inc
purpose aim study describe health related quality life hrqol persons explore influencing factors design secondary analysis data cross sectional survey subjects setting eight hundred twenty seven persons living enrolled provinces cities china october november final sample comprises individuals completed data collection mean age years range years methods health related quality life assessed using chinese language version city hope quality life questionnaire chinese version sociodemographic data clinical characteristics self efficacy adjustment social support psychological state patients measured general information questionnaire also administered self efficacy scale adjustment inventory chinese version social support scale hospital anxiety depression scale results patients overall hrqol patients moderate range mean score scores physical domain psychological domain social domain spiritual domains also moderate range respectively multivariate analysis found multiple factors influenced hrqol persons gender religious belief marital status psychological factors depression anxiety specific components related social support self efficacy care adjustment conclusion health related quality life among chinese patients fecal less optimal influenced multiple demographic psychosocial factors additional research needed design strategies improve hrqol population
dysfunction iron metabolism includes uptake storage release plays key role neurodegenerative disorders including parkinsons disease alzheimers disease disease understanding iron substantia nigra specifically targets dopaminergic neurons particularly warranted knowledge provide new therapeutic avenues targeted strategy disease review begin brief introduction describing brain iron metabolism regulation provide detailed description iron specifically neurons especially vulnerable iron furthermore focus possible mechanisms involved iron induced cell death neurons finally present evidence support iron represents therapeutic strategy
achieve better understanding mechanisms underlying anti asthmatic action inhaled systemic glucocorticoids provide data regarding risk negative effect inhaled cells study conducted effect effector regulatory treg resting cells within respiratory extra respiratory tissues mouse model allergic asthma study indicated one possibly key mechanism underlying anti asthmatic action inhaled systemic prevention activation clonal expansion cells lymph nodes consequently prevents infiltration lungs cells beneficial effects asthma treatment mediated increased recruitment treg cells lungs local generation treg cells results demonstrated inhaled systemic induced comparable depletion normal treg cells head neck lymph nodes peripheral blood furthermore inhaled systemic therapy led loss cells lungs thus study suggests inhaled therapy safer systemic one respect adverse effect cells present within outside respiratory tract moreover administration inhaled produce negative effects lung residing cells elsevier rights reserved
background early life stress addiction related age related diseases telomere shortening however role telomere length crack cocaine addiction remains unknown purpose study investigate sample crack cocaine dependent women reported history community based sample elderly women reference group senescence methods study included treatment seeking crack cocaine women elderly women without psychiatric diagnosis crack cocaine sample divided two groups according childhood trauma questionnaire scores presence history childhood abuse neglect crack absence history crack assessed ratio obtained peripheral blood dna using quantitative pcr assay crack crack subjects exhibited shortened comparison group despite younger age among crack cocaine sample crack group significantly shorter telomeres crack group correlation analysis within crack cocaine group indicated negatively correlated emotional abuse scores conclusions results support previous findings telomere shortening drug addiction study suggests new evidence distinct biological phenotype drug dependent women results support biological senescence hypothesis underpinning experience elsevier inc rights reserved
condition subtle femoral head hip result pathological hip motion common cause hip pain lead cartilage damage osteoarthritis patients surgical intervention indicated improve quality life potentially delay onset osteoarthritis patients however surgery significant cartilage damage already occurred unfortunately current imaging modalities rays conventional mri subjective lack sensitivity distinguish two groups reliably paper describe pairing mapping data objective mri sequence spatial proportional odds model surgically obtained ordinal outcomes scale cartilage damage hip study assigned spatial dependence parameter process prior distribution permits clustering said parameters using fitted model produce six color patient specific predictive map entire cartilage maps facilitate patient education clinical decision making copyright john wiley sons ltd
study modeling lagrangian systems multiple degrees freedom based system dynamics canonical parametric models require hoc sometimes simplification solution hand due lack prior knowledge systems structure modern nonparametric models machine learning face dimensionality especially learning large systems paper bridge gap theories lagrangian systems vector valued reproducing kernel hilbert space lagrangian systems kernels governing euler equation lagrangian kernels show kernels span subspace capturing projection inverse dynamics property model uses inputs outputs machine learning structured form system dynamics thereby removing need new systems generalization problem learning effect systems lagrangian simpler task directly learning dynamics demonstrate applied proposed kernel identify robot inverse dynamics simulations experiments results present competitive novel approach identifying lagrangian systems despite using inputs outputs
due environmental safety limitations exhaust emissions internal combustion engine become severe important pollutants diesel engine oxides nitrogen hydrocarbon carbon monoxide found literature various cylinder combustion treatment methods ceramic coating piston like carbon coating piston coating piston various ceramic coatings cylinder head liner used diesel engines improve performance reduction various emissions present investigation attempt made study performance emissions direct injection diesel engine using nano catalyst nano coated coated copper cadmium nano catalyst top piston using plasma techniques engine performance emission characteristics compared baseline engine observed significant improvement performance reduction various pollutants emitted diesel engine
objectives postpartum depression impacts women postpartum depression associated impaired bonding development marital suicide however current standard care screen women postpartum depression study modeled cost effectiveness physicians screening treating postpartum depression psychosis partnership methods study follows hypothetical cohort pregnant women experiencing one live birth year time horizon used decision tree model obtain outcomes screening treating postpartum depression psychosis using postnatal depression scale use medicaid perspective cover approximately births cost effectiveness intervention measured cost per remission achieved cost per quality adjusted life year gained conducted deterministic probabilistic sensitivity analyses results screening treating postpartum depression psychosis produced healthy women cost per woman incremental cost effectiveness ratios intervention branch compared usual care per gained commonly accepted willingness pay threshold gained per remission achieved results robust deterministic probabilistic sensitivity analyses input parameters conclusions practice screening treating postpartum depression cost effective intervention considered part usual postnatal care recently proposed recommendations preventive services task force
microstructures scale tens change physical properties objects making flexible traditionally difficult produce additive manufacturing now physically realize microstructures low cost paper propose study procedural microstructures inspired open cell absence regularity simple approach grade foam geometry thus mechanical properties within target object surface rather requiring global optimization process microstructures directly generated exhibit specified elastic behavior implicit evaluation procedural computer graphics locally follow elasticity field allows detailed structures generated large objects without explicitly produce full representation mesh complete object structures added fly just object slice manufactured study elastic behavior microstructures provide complete description procedure generating explain determine geometric parameters microstructures target elasticity evaluate result printed samples finally apply approach fabrication objects spatially varying elasticity including implicit modeling frame following object surface seamlessly connecting microstructures
key concept describing complex relationship anxiety cognitive control one hand cognitive control processes underlie specific tendency engage trait worry conceptualized future oriented mental problem solving activity hand general tendency experience signs symptoms anxiety trait anxiety suggested impair cognitive control thoughts interfere task relevant processing based opposing tendencies predicted effect two related constructs trait anxiety trait worry one another statistics instances termed suppressor situations four experiments found evidence suppressor situation shared variance controlled trait worry positively whereas trait anxiety negatively related performance memory task requiring strategic retrieval also showed opposing effects related temporal context results suggest trait worry trait anxiety possess unique sources variance differently relate performance memory tasks requiring cognitive control
feature selection one significant steps machine learning reduces features space order achieve faster learning yielding simpler models high accuracy rapid development technologies large scale high dimensional datasets common today performance traditional feature selection techniques suffer scalability issues parallel feature selection obvious solution deal problem due advent many distributed computing frameworks scalable computing become viable strategy reference feature selection present work proposes distributed parallel feature selection technique employs vertical distribution strategy dataset exploit parallel computation uses information gain filter based ranking method evaluates multiple feature subsets dataset parallel key idea distribution evaluation rank generation features several computing nodes parallel experiments performed multiple large scale high dimension datasets significant reduction overall computation time achieved
studies demonstrated low expression mir associated cell proliferation migration wide variety tumors studied expression mir relation occurrence development breast cancer total rna breast cancer tissue corresponding adjacent normal tissue extracted used detect mir expression quantitative real time polymerase chain reaction qrt pcr also transfected breast cancer cells mir mimics mir inhibitor mimics negative control mimics inhibitor negative control inhibitor cell proliferation analyzed colony formation assays methyl assays cell proliferation breast cancer cells decreased overexpression mir increased following mir suppression cell migration invasion assessed using transwell wound healing assays respectively also decreased overexpression mir increased mir suppression breast cancer cells finally western blot assays showed expression mir inhibited expression transforming growth factor beta tgf beta collectively data suggest mir inhibit tgf beta protein expression turn contribute tumor formation
older adults time younger adults remembering specific events experiences episodic memory whereas ability use ones general knowledge either improves remains stable life span focus sometimes overlooked critical possibility intact general knowledge facilitate older adults episodic memory performance reviewing literature shows prior knowledge support remembering aging lead consider open questions including whether prior knowledge used fill gaps memory failure older adults need instructed apply prior knowledge overall claims within theories cognitive aging prior knowledge key factor understanding older adults memory performance potential serve compensatory mechanism
paper investigate stability positive negative feedback linear system hysteresis operator provide sufficient conditions linear plant operator based input output property plant hysteresis operator show application main result design linear controller stabilize simple mechanical system driven actuator actuator smart material based actuator elsevier ltd rights reserved
advanced science technology based carbon based nanomaterials experiencing rapid rate change performance capabilities substitute serve alternative approaches existing technologies one major environmental concerns water pollution heavy metals heavy metals water main many years toxicity towards aquatic life human beings also environment context water wastewater treatment significant numbers achieved drive accelerated change capability improvements contribution unique features promising carbon based nanomaterials generated tremendous interest among material researchers described along potential applications water wastewater treatment carbon based nanomaterials stand one highly efficient nanomaterials due vast availability lower production cost compared nanomaterials paper critically reviewed application different type carbon based nanomaterials water wastewater treatment carbon nanomaterials role adsorption membrane separation mechanisms enable applications discussed advantages limitations barriers research needs highlighted challenges include technical high cost environmental health risk taiwan institute chemical engineers published elsevier rights reserved
novel design two degree freedom dof compliant tool tip powered surgical tool presented paper tool tip pitch using corner based compliant joints integrated compliant tool tip realized six compliant joints placed alternating fashion orthogonal tool externally powered consists drive box stainless steel tube compliant tool tip distal end drive box houses command input three servo actuators microcontroller microcontroller maps surgeons command input tool tip orientation actuation design tool tip actuated tensile forces exert compressive load compliant joints since compressive load carrying capacity based compliant joints limited design enhance compressive capacity compliant joints circular guide presented finite element simulation done verify design compliant joints experiments carried assess relationship force input servo actuators joint deflection additional experiments carried determine maximum force exerted compliant prototype complete surgical tool built demonstrate utility proposed compliant tool tip alternative traditional tool tip powered surgical tool
efficacy antiviral treatment chronic hepatitis virus hcv infection determined measuring hcv rna specific time points throughout therapy using highly sensitive accurate hcv rna assays study compared performances two recently developed real time pcr hcv rna assays hcv use systems hcv hcv use system hcv two established assays taqman hcv quantitative test version cap taqman hcv test version use high pure system limits detection linearity lower concentrations assessed hcv hcv using standard panels representing hcv genotypes pairwise assay comparisons also performed using clinical samples representing hcv results hcv hcv linear low hcv rna concentrations log difference expected observed results respectively new assays showed excellent agreement results cap samples viral loads using million cutoff high among four assays conclusion hcv hcv tests sensitive linear correlate established assays used clinical practice
present work aimed developing vector construct suitable restoring fertility transgenic male sterile tobacco plants expressing male inducing cell layer vectors produce either intron hairpin rna induce silencing region developed using selected fragment constructs independently agrobacterium used transforming tobacco generation plants carrying gene homozygous condition identified crossed male sterile transgenic tobacco plants obtain hybrid seeds pcr analysis hybrid plants indicated segregation inducing cassette plants carried cassette hybrid plants produced fertile pollen grains formed normal upon molecular analyses hybrid plants pcr northern blotting sirna detection revealed intron interrupted hairpin rna rna mediated gene silencing effective compared silencing indicated complete degradation transcripts formation higher levels specific sirna molecules plants carrying rna construct segregation analyses hybrid plants confirmed segregation gene traits hybrid ratio taken together results established intron hairpin rnai mediated silencing transcripts restored fertility transgenic male sterile tobacco plants expressing rna efficient silencing transcripts
synthase gene cloned peanut plant pcr transformed sweet potato agrobacterium mediated transformation stem sections infected bacterial solution min days infected explants cultured media containing induction containing root formation root induction rates respectively regenerated plants obtained positive plants pcr southern blotting analyses high level dry weight detected transformed plants hplc study also provides stable genetic transformation plant regeneration method metabolic modification sweet potato
developed procedures repeated reproduction person repeatedly information serial reproduction people transmitting information one person another experiment directly compared recall accuracy across two techniques previously reported using drm word lists recall initial study list words remained constant across repeated declined markedly across serial contrast recall associated words originally studied critical words steady across conditions original list words across link serial reproduction chain proportion critical items recalled relative list words increased significantly list passed people using output bound scoring serial reproduction resulted lower accuracy repeated reproduction final recall trial results broadly consistent informal observations serial reproduction produces greater original material repeated reproduction also leads greater distortion relative proportion correct material recalled society applied research memory cognition published elsevier inc rights reserved
cis modular assembly lines largely structurally enzymes within recently discovered trans synthase assembly lines just starting observe examine first synthase module peptide synthase resolution naturally reduces alpha beta groups known biosynthesis isolated reduced bound beta substrate alpha beta hydroxy product also substrate alpha beta product substrates enter active site opposite directions generate stereo suggests acyl moiety capable accessing different despite anchored residue acyl carrier protein features enabling alpha extensive since naturally reduces group within cis synthase identified performs completely reduction substrate generate alpha product sequence analysis trans reveals single residue rather three residue motif found cis predictive orientation resulting beta hydroxyl group
paper describes concept conversion movement wave power plant characterize high force low speed energy high speed low force energy linear machine using gas springs wave power plant moving slowly force raising wave gravitational force wave enormous enormous force combined movement presents much concentrated energy linear electric generator converts low speed high force ocean wave energy electrical energy direct conversion piston generator moving way cost effective due large size expensive concept converting slow movement low frequency ocean energy faster movement high frequency reduce size generator using double gas spring presented
recombinant proteins offer many therapeutic advantages unavailable traditional small molecule drugs need cellular versus chemical synthesis production avenues producing therapeutic biologics continuously expanding developments biochemistry cell biology fuel new discoveries promise safer efficient cheaper drugs consumers numerous approaches express recombinant proteins exist escherichia coli saccharomyces cerevisiae mammalian systems chinese ovary cells widely utilized improvements production hosts focused novel expression cell line modifications engineering secretion pathways media design describe recent developments improving protein production coli cerevisiae systems compare recent advancements previous knowledge field expanding importance prevalence protein therapeutics improvements serve framework future discoveries
recent years significant attention given renewable energy integration within context global climate change energy water literature recognized electricity water infrastructure enables production distribution consumption two two issues seem unrelated resolution potentially synergistic renewable energy technologies present low emissions also low water intensities therefore renewable energy integration potential address sustainability concerns yet renewable energy integration studies yet consider integrated energy water infrastructure many works rely coupled unit commitment economic dispatch simulation recently simultaneous optimization method contributed economic dispatch networks include water power production facilities paper builds upon foundation development corresponding unit commitment problem demonstrates optimization several case studies inspired singapore middle east concludes renewable energy simultaneously reduces emissions water furthermore shows water storage help alleviate binding production constraints production profiles reduce production cost levels elsevier ltd rights reserved
real time rapid emergency control model proposed cope sudden water pollution accidents long distance water transfer projects model outputs method based pollutant properties generalized form model proposed tested project rapid prediction formulas emergency control parameters proposed different states water closing times check gates pollution range calculated rapid prediction formulas case study examined scenario sucrose project conducted channel beijing emergency water supply project middle route south north water transfer project relative errors peak concentration arrival time peak concentration less however use actual toxic soluble pollutant validate model performed experiment sucrose test model based concentration variation final result shows model able play fundamental role decisions involved emergency environmental decision support system
background aim learning changes communication dementia important order improve services support families explored family members views changes communication ways communication adapted due progression dementia methods qualitative content analysis thematic interviews conducted eight close family members results decreasing vocabulary increasing sign finding difficulties conversations became poorer tended topic nonverbal communication became important verbal communication abilities deteriorated adult children took active role taking initiative guiding conversations conclusion seem similar changes communication hearing people dementia adult children need get used interpreting assisting parents communication different phases dementia
study examined effect training programme conventional football practice warm lower limb neuromuscular control purpose built active movement extent discrimination apparatus used assess lower limb neuromuscular control one professional australian football league without vision contact point participants performed backward swing movement trials leg made judgment magnitude movement scores representing ability discriminate different movement calculated area players receiver operating characteristic curve constructed using non parametric signal detection theory methods participants randomized either intervention control group performed different procedures warm prior football practice sessions week period tested intervention group performed programme specific improvement running technique function control group performed usual warm stretching running increasingly intense football backward leg swing extent discrimination significantly better players following week programme compared discrimination scores players performed usual practice warm significant improvement observed lower limb neuromuscular control movements similar late swing early stance phase running programme therefore improve control specific aspect sensorimotor system performance useful particularly athletes lower function levels deemed risk injury sports medicine australia published elsevier ltd rights reserved
paper presents design approach interior permanent magnet machines variable flux characteristics using low force magnets improved efficiency extended operating speed range flux type used design due positive operation reduced loaded effects design considerations machine structures variable flux machine attributes discussed addition leakage flux rotor particularly designed also obtain another flux varying capability evaluation designed machine provided finite element analysis simulations experiments proof principle machine designed machine shows benefits increasing efficiency speed range low torque region variable magnetization control low force magnets design leakage flux proposed paper implemented
study examined influence model minority stereotype perceived mental health functioning asian americans hypothesized college students perceive asian americans fewer mental health problems clinical symptoms whites due model minority stereotype four hundred twenty five undergraduate students white college campus american northeast randomly exposed one four conditions clinical describing white college student suffering adjustment disorder describing asian american college student article describing success story whites white clinical article clinical describing asian american following exposure one conditions participants completed memory recall task measures attitudes towards asian americans attitudes towards group members perceived mental health functioning participants exposed primed positive model minority stereotype perceived target regardless race ethnicity better mental health functioning less clinical symptoms condition without stereotype additionally stereotype primer found modest predictor perception mental health functioning asian american results light impact model minority stereotype asian americans mental health status contributing neglect minority groups mental health needs
beta entered phases clinical trials treatment solid tumors therapeutic efficacy beta closely related metabolic process order contribute better understanding human metabolism beta used microbial model mammalian metabolism beta two new derivatives produced chemical structures elucidated hydroxy beta hydroxy beta nmr nmr analyses major derivative displayed lower activity breast cancer cell line beta show cytotoxicity normal fibroblasts cell line whereas beta highly toxic metabolites reported first time similar occur phase human metabolism society europe published elsevier rights reserved
high dynamic range content dynamic range image important characteristic algorithm design validation analysis aesthetic attributes content selection traditionally computed ratio maximum minimum pixel purely objective measure however human visual systems perception dynamic range complex largely neglected literature paper new methodology measuring perceived dynamic range images proposed benefit number ways evaluating inverse tone mapping operators compression methods parameter content selection perceptual studies subjective study conducted data set images results showed strong agreement across participants allocated scores addition high correlation ratings stimuli found based results pilot study five objective measures pixel based dynamic range image key area bright regions contrast selected candidates predictor model two found significant contributors model analyses show model performs better individual metrics stimuli
paper aimed determine stochastic response suspension bridge subjected spatially varying ground motions considering geometric nonlinearity suspension bridge built turkey europe asia selected numerical example spatial variability ground motion considered wave passage site response effects importance site response effect arises difference local soil conditions different support points structure also investigated end study mean maximum variance response values obtained spatially varying ground motions compared cases ground motion model seen component spatially varying ground motion model important effects dynamic behaviour bridge response values obtained general excitation case also includes site response effect causes larger response values homogeneous soil condition cases variance values calculated general excitation case dominated dynamic component deck asian side tower response values obtained site response effect alone larger response values obtained wave passage effects separately concluded suspension bridges sensitive spatial variability ground motion therefore wave passage especially site response effects considered stochastic analysis type engineering structures
hilbert space singular integral operator non shift conjugation considered continuous functions unit circle shift operator operator complex conjugation show symbolic computation capabilities computer algebra system used explore dimension kernel operator analytical algorithm presented several examples given
previous research examined age contexts males females develop gender congruent stereotypes research indicates social experience provide great influence presence stereotypes likely influenced development gender schemas current study interviewed children years sub rural university community females age males age individually asked boys girls particular activities aggressive behaviors prosocial behaviors generally males tended express holding beliefs indicating gender congruent expectations items one domains however females expressed multiple beliefs four contexts social cognitive explanations phenomena discussed current study important addition existing literature preschool teachers parents alike able assist children better develop activities behavioral habits gender related stereotypes fail develop
online question answer emerging excellent learning platforms learners varied interests paper present results clustering stack users four clusters namely naive users users experts clustering based various metrics available use means expectation maximization clustering algorithms compare results results validated using internal external relative validation techniques objective clustering able trace predict activity user according results majority users users consideration fall experts category indicates users stack high quality thereby making excellent platform users learn computer programming
dye heme enzymes comprise family alpha beta structural superfamily proteins first identified relatively recently fungus characterized ability catalyze based industrial dyes enzymes now known present three domains life appear occur plants animals involved range physiological processes although many cases roles remain unknown prevented development potential includes transformation review highlights functional diversity light phylogenetic structural biochemical data phylogenetic analysis reveals existence least five classes potential physiological roles discussed based part analyses finally considerable biotechnological potential summarized crown copyright published elsevier inc rights reserved
article present literature reviews fire prevention methods especially mining industries using thermal image processing techniques fire protection systems crucial increased loss human lives due coal fatal coal across world past decades growth demand energy mining coal expected year determining conditions leading fire paramount detect uncertain fire conditions thermal imaging considered significant among several early warning methods recognize spontaneous combustion coal temperature recordings sensors testing gas tests evolution imaging applied various industrial sectors coal oil building security numerous applications mathematical models presented light safety dimensions mining industry missing links areas mathematics application thermal image processing mining especially coal industry evolved gap knowledge suggested statements
include various approaches ranging stimulating effector mechanisms inhibitory suppressive mechanisms creating discussing effective means advancing therapies imaging focus newly formed imaging cellular immune therapies interest group within world molecular imaging society efforts made identification validation predictive biomarkers number without predictive biomarkers considerable number patients receive treatments chance offering benefit reflect poorly field immunotherapy yield false patients time contributing significant cost healthcare system review summarizes main strategies cancer immune cell based therapies discusses recent advances imaging strategies aimed improve cancer immunotherapy outcomes
previous studies suggested tendency internal thought related auditory hallucinations even auditory hallucinations ahp general population however although auditory hallucinations related emotional phenomena studies investigated effect emotional valence aforementioned relationship addition know component psychotic phenomena relate externalizing bias current study replicated previous research suggested individual differences auditory like experiences strongly correlated external internal thoughts conceptualized terms false memory using deese roediger mcdermott drm paradigm found significant relationship experimental performance total scores scale among factors mental image said predictor auditory hallucinations significantly related experimental performance investigated potential effect emotional valence using drm paradigm results indicate participants low scores low ahp group current study showed increased index positive words decreased negative words however effects emotional valence found participants high scores high ahp group study indicated external internal thoughts predicts ahp high ahp group showed smaller emotional valence effect drm paradigm compared low ahp group discuss outcome perspective dual process activation monitoring framework drm paradigm regard emotion driven automatic thought false memory
occurrence psychotic autism spectrum disorder asd symptoms represents important clinical challenge consider problem context computational psychiatry approach applied conditions predictive coding symptoms schizophrenia explained terms failure top predictions enhanced weighting bottom prediction errors likewise autism explained terms similar perturbations suggest theoretical overlap explain overlapping symptomatology experimental evidence highlights meaningful disorders hypothesize individuals asd experience degree without presence additional impairment hallucinations likely indicative distinct process
organizational values guide acceptable behavior provide motivational marketing channel literature yet address impact values exchanges propose value firms effective governance method research examines impact value manufacturers primary survey data manufacturing firms demonstrate perceived value positive effect performance moreover information sharing joint problem solving serve mechanisms partially mediate main effect research calls integration organizational values partner selection marketing channel governance elsevier inc rights reserved
objective evaluate longitudinal changes inflammatory markers predict cardiovascular disease events among smokers making quit attempt characterize cross sectional associations smoking smoking approach results longitudinal cohort study contemporary smokers evaluated independent associations smoking markers exhaled carbon monoxide cigarettes pack years inflammatory markers reactive protein dimer urinary creatinine ratio white blood cell count effects smoking cessation continued smoking inflammatory markers year among smokers made aided quit attempt part randomized comparative effectiveness trial standard care strong independent associations smoking markers ratio high sensitivity reactive protein dimer participants mean years old women non white smoked cigarettes pack years year successful gained weight versus larger increases insulin resistance scores continuing smokers despite increases significant decreases ratio counts changes markers related quitting conclusions smoking associated increased ratio counts cessation improves ratio counts independent weight change suggesting reduced inflammation related less oxidant stress
across districts taiwan designed bypass partial discharge river heavy rainfall events purpose flood control flood way open channel supported single double cantilever walls side banks installed assisted method twenty days completion put work first time heavy rainfall unexpectedly cantilever walls several sections failed caused collapse slope behind walls paper explores failure mechanism real causes failure case based conditions hydraulics failure processes results stability analyses concluded ignoring possible bed bank erosion likely primary problem design critical condition water level quickly dropped resulted rapid failure case avoided rapid condition potential channel bed considered elsevier rights reserved
environmental persistence endocrine disrupting estrogen chemicals subsequent endocrine function even concentration environmental matrices significant global attention due possible disruptive effects intact organism progeny attempt made present study investigate occurrence two estrogens viz natural synthetic alpha surface bodies india studied water bodies documented presence estrogens concentrations among six water bodies highest level synthetic estrogen found relatively higher concentrations natural estrogen observed tank presence estrogens water bodies attributed environmental changes socio economic development wide spread use birth control pills direct release agricultural farm waste surface runoff industrial agricultural activities etc compared natural estrogen synthetic estrogen observed higher concentrations water bodies receive domestic sewage mostly middle income groups natural estrogen found higher concentrations water bodies receive water agricultural activities multiple linear regression analysis significance confidence employed predict concentration estrogens based physico chemical parameters water bodies surface plots used evaluate functional role estrogens water quality parameters best knowledge report first study monitoring estrogens indian water bodies
present new mathematical theory explaining fluid mechanics flight fundamentally different existing boundary layer circulation theory formed year ago new theory based new resolution paradox showing slightly viscous body flow viewed zero drag lift potential flow modified rotational slip separation arising specific separation instability potential flow turbulent flow drag lift wing separation mechanism maintains large lift potential flow generated leading edge price small drag resulting lift drag quotient size small plane speed reynolds number approximate take landing approximate allows flight affordable power new mathematical theory supported computed turbulent solutions navier stokes equations slip boundary condition model observed small skin friction turbulent boundary layer always arising close accordance experimental observations entire range angle attacks including using millions mesh points full wing body configuration
antibody drug conjugates comprise antibody linker drug payload selection tumor specific antibody development linker efficient controlled drug release critical steps developing fully functional effective adc research strategy molecular imaging technologies employed evaluate efficiency antibody delivery linker preclinical setting antibody delivery tumor area antibody penetration tumor malignant lymphoma pancreatic tumor evaluated vivo fluorescence imaging technique positron emission tomography pet imaging studies conducted using labeled antibody evaluate tumor targeting spontaneous carcinogenesis model model dense similar human cancer drug imaging system using microscopic mass spectroscopy enhanced resolution sensitivity used evaluation incorporated high molecular weight carrier showing similar properties adc analyzed contrast free selectively increased drug accumulation tumor reduced toxicity normal tissues enhanced permeability retention effect drug imaging system used recently evaluate adc linker present work development adc using molecular imaging technique
paper generalized variable coefficient equation investigated based bell polynomials auxiliary variable bilinear forms equation obtained one two three soliton solutions given hirota method symbolic computation soliton solutions also constructed multi soliton interaction propagation investigated illustrated properties multi soliton interaction different planes space depend forms variable coefficient positions solitons change wave numbers reverse signs
childrens knowledge food allergies self management developmentally based essential safe transition school despite growing number children food allergies starting school globally date little known young childrens knowledge food allergy capacity manage feelings perspectives starting school addressing gap pilot study interviewed six children aged four six years family homes australia food allergy starting school data photo interviews utilising photos analysed thematically results pilot study suggest childs knowledge food allergy self control resist ability communicate need help help stay safe school therefore vital transition school implications pilot study research discussed
norway experienced internet voting municipal respectively security depends assumptions involving organizations completely independent reliable receipt codes sent paper point following aspects privacy norwegian scheme box receipt generator private key decryption service obtained two former players propose solution avoid issue without adding new players assure correctness receipt codes sent pre channel service post channel short message service however holding receipt code reveal even albeit fairly solution intentional revealing still problem suggest case codes generated pre channel secure different candidate without detection propose solution verify integrity receipt codes copyright john wiley sons ltd
local high points widely exist wastewater pressure pipe system reality wastewater pumps switched force always usually assumed understanding hydraulics gravity driven pipes important reliable operation wastewater pumping study differentiation based method developed determine temporal spatial dynamics wastewater force main solving equations involving pump curves system curves gravity driven flows solutions equations determine operation points pumps method applied wastewater pumping system city florida multiple local high low points force main field investigations theoretical analyses incorporated calibrate pump head characteristic curve pipe friction coefficient enabling accurate simulation force main hydraulics simplicity method interest water utility engineers american society civil engineers
cardiovascular disease one leading causes death psoriatic arthritis psa pathogenesis accelerated atherosclerosis psa remains elucidated endothelial dysfunction often atherosclerosis study aims assess carotid media thickness marker atherosclerosis psa context markers inflammation vascular function cross sectional study performed psa patients compared controls matched age sex flow mediated assessed health ann endothelial progenitor cells quantified flow cytometry measured inflammatory measures included disease activity score joints count disease activity index psoriatic arthritis also assayed markers inflammation including reactive protein crp erythrocyte sedimentation rate esr proinflammatory cytokines interleukin tumor necrosis factor tnf alpha endothelial dysfunction including lipids intercellular adhesion molecule vascular cell significantly higher psa patients compared controls whereas high density hdl cholesterol significantly reduced psa compared controls compared controls psa patients significantly increased concentrations esr crp tnf alpha psa positively correlated inversely correlated hdl psa impaired indicating endothelial dysfunction accelerated atherosclerosis respectively psa related inflammatory mechanisms tnf alpha markers vascular function crp involved development vascular disease psa cytokine triggered inflammation expression adhesion molecules endothelial dysfunction increased psa
exert potent effects eukaryotic cell plasma membranes used sub concentrations significantly augment cytotoxicity based help elucidate mechanism behind two phenomena investigated role cholesterol human lymphoma cells lipid deprived using combination three different approaches following treatment total cellular lipid content analyzed ionization mass spectrometry plasma membrane cholesterol content measured using fluorescent probe maximal lipid deprivation cells resulted complete loss sensitivity similarly augmentation anti lost without concomitant loss intrinsic cytotoxicity activity restored following incubation lipid deprived cells ldl effect cytotoxicity cells restored following cholesterol levels ldl fluorescence analysis cellular lipids demonstrated restoration activity entirely due increased cholesterol levels restoration cellular cholesterol levels ldl also restored effect effect associated cholesterol minor changes phospholipid species results indicate properties cholesterol dependent contrast intrinsic cytotoxicity least partially cholesterol independent elsevier rights reserved
older people lower socioeconomic status ses disproportionately affected chronic conditions yet less able compensate health limitations use formal long term care home preferred type care like older women single people particularly vulnerable public care scheme aims care home empowerment users study analyses ses gender informal family care factors associate use old age formal home care adaptation theory used identify material resources income health resources care needs informal caring resources residence availability family care gender aspects also considered persistent source inequalities administrative survey data collected public authorities serve compare home care use old age support forms residential informal care using logistic regression analysis results show pro rich bias home care use among single living people high income single people less likely move care home significant income differences present non second traditional gender roles salient female care recipients residing partner likely use formal care men reflecting mens traditional gender roles involve less care work womens conclusion urban setting care scheme likely reinforce along gender class thus implementing general policy objective care home likely higher income support mechanism promoting empowerment among older people contribute unequal degrees choice especially fewer resources manage way fragmented system delivery
hypothesis mindfulness meaning theory inquiry inquiry proposes mindfulness generates promoting positive positive psychological process stressful events benign meaningful growth promoting test hypothesis examined prospective relations state mindfulness positive community sample participating mindfulness based intervention seven weekly time points throughout participants engaged min mindfulness exercise home completed measure degree state mindfulness experienced measure use positive previous week support hypothesis mindfulness meaning theory found latent growth curve multivariate autoregressive latent trajectory models increases trajectory state mindfulness experienced significantly robustly associated frequent use positive course participation week long thus mindfulness enhance one another components positive feedback loop whose structure best described upward
recent times become technology enabled platform allows delivery content locations geographically separated institute technology science bits platform successfully used deliver content multiple namely campus campus campus present paper challenges faced implementing solutions attempted tools required make learning computer programming course better experience particular described handled bits campus
mutations genes account one third prevalence parkinsons disease non carriers mutations represent population risk future development patient carry mutations gene demonstrates significant cognitive decline compared idiopathic patients assessed cognitive domains using fmri among mutations better understand pre motor cognitive functions populations twenty one non non carriers participated study evaluated using standard questionnaires scanned performing two separate cognitive tasks interference task back working memory task cerebral activation patterns assessed using whole brain predefined region interest roi analysis subjects matched demographic clinical characteristics task spite similar behavior demonstrated increased task related activity right medial frontal gyrus reduced task related activity left gyrus compared addition higher activation patterns incongruent task compared left medial frontal gyrus bilateral gyrus whole brain differences noted groups back task paired cognitive task related performance indicate higher activation patterns incongruent condition among compared represent compensatory mechanism enables adequate cognitive performance
female university students age active sexual life desire delay becoming mothers thus making provision correct timely information contraception crucial study aims investigate level awareness information behaviour contraception among female university students using simple random sampling select participants nine colleges federal university agriculture nigeria total questionnaires administered completed findings showed awareness contraception among respondents known contraceptive methods male condom oral pills respondents first contraception secondary school respondents frequent sources contraception information friends television preferred sources physicians health workers parents university lectures major barriers faced seeking information contraception inability get reliable accurate information lack time fear measures increase adoption contraception among female students take preferred sources information deliver correct adequate information contraceptive methods
transition university stressful successful adjustment imperative historically research transitional stress focussed negative outcomes health first study applying positive psychology approach investigate characteristics facilitate adjustment among new university students range psychological strengths factors shown individually influence stress subjective relationship assessed among first year undergraduates week three first semester months later path analyses revealed mediated relationship stress negative affect component time academic self efficacy demonstrated significant relationships life satisfaction positive affect contrary predictions stress levels remained stable time although academic increased self efficacy decreased emerged key factor new students adjust university helping buffer impact stress throughout academic year incorporating stress management psycho educational interventions develop strengths discussed way promoting confidence agency new students help cope better stress university
study discusses aspects doctor patient communication presents preliminary analysis doctor patient interactions italy aim gain information mis communication doctors patients affect doctor patient relationship lead patients lack trust doctors authors use corpus existing audio video materials italian doctor patient interactions analyse doctors use verbal nonverbal expressions exchanges patients analysis aimed identify features communication problems leading perception doctors distant unreliable preliminary findings reveal patients lack trust doctors also result doctors use culture specific patterns verbal nonverbal expressions example certain used minimizing patients specific gestures signalling distance closure findings used planning future investigations doctor patient interactions based collection analysis audio visual material detailed knowledge patterns mostly affect communication natural settings provide important information implemented digital devices
agent shown stably reduce patients heart rate setting acute cardiac care however association atrial fibrillation risk acute treatment remains controversial clinical issue thoroughly investigated abnormal atrial induced treatment enhance vulnerability induction especially nerve concurrently activated aimed experimentally investigate effects acute treatment without concurrent activation dogs cervical nerves prepared electrical stimulation induction rate determined atrial burst atrial action potential duration atrial effective refractory period erp obtained consecutively baseline delivery alone intravenous injection group saline saline group delivery drug group alone significantly lowered compared baseline significantly lowered compared alone contrary expectations significant differences trends temporal dispersion erp saline groups irrespective whether saline injected significantly shortened erp increased interestingly although response injection intense alone significantly lower injection alone conclude despite intense effect acute treatment increase irrespective underlying activity study constitute support safety using setting acute cardiac care
analog clock generator built complementary logic cells delivers robust symmetrical required control high performance differential switched capacitor circuits using back gate feedback sizing static dynamic symmetry proposed solution tolerant process inherent variations deep nanometer cmos processes
quitting smoking young adulthood substantially reduce tobacco related morbidity mortality later life depressive symptomatology prevalent among smokers increases risk poor smoking cessation outcomes however integrated behavioral interventions simultaneously target smoking depressive symptoms rarely young smokers included development interventions paper describe session behavioral activation based treatment smoking adapted youth conducted series focus groups young adult smokers depressive symptoms order treatment developmentally appropriate subsequently completed small pilot group intervention provide preliminary data feasibility acceptability outcomes provide case series participants order provide clinical modified treatment implemented among young adults pilot study participants exhibited smoking abstinence smoking reductions end treatment improvement depressive symptoms maintenance levels activation environmental reward participants provided positive qualitative constructive feedback regarding intervention
effectiveness symptoms sleep disorders plus long term safety combination extracts combined soy assessed postmenopausal women controlled study carried menopausal women comparing combination group formulation containing alone group dosage recommended index pittsburgh sleep quality index short form determined baseline three six months endometrial thickness density liver function evaluated baseline months one hundred eighty women enrolled study group group end treatment density endometrial thickness hepatic function show substantial differences groups index particularly tendency hot progressively significantly decreased frequency severity versus treatment time significant increase sleep quality wellness parameters observed versus groups adverse events observed combined effectively safely used symptomatic postmenopausal women mainly quality sleep complaint glands liver function unaffected months treatment
view known sensitivity developing central nervous system pollutants sought assess effects exposure heavy metal naturally present environment behavior young rats impact oxidative stress hippocampus pups form nitrate doses weeks birth control rats mineral water locomotor activity open field practice effects device decreased rats exposed respectively respectively compared control rats anxiety depressive like behavior altered exposure lipid peroxidation protein carbonyl concentration increased significantly exposure significant increase superoxide dismutase sod glutathione peroxidase activities also observed hippocampus rats exposed results demonstrate exposure since birth alters behaviors modifies antioxidant status
objectives emergency contraceptive pills preventing unintended pregnancy women willing use even risk paper examines whether increased knowledge increase intention use products methods factors associated intention use emergency contraception assessed among women participated nationally representative sexual health netherlands survey logistic regression models included demographics prior use knowledge results seventeen percent women use unprotected sexual intercourse whether use intention strongly related prior use children two six knowledge items related intention multivariate analyses aware obtained without prescription intention whereas knowing woman still get pregnant taken negative impact intention conclusions improving knowledge contribute intention use role modest understand reasons behind use essential study contribution factors like attitudes social norms
purpose surface roughness important parameter manufacturing engineering significant influence performance mechanical parts failures sometimes catastrophic failures leading high costs components surface roughness owing need improvement machining parameters order obtain prescribed surface roughness new developments recently investigated work aims report study optimisation model based genetic algorithms gas design methodology approach developed algorithm considers machining parameter data population obtained experimental tests exchange structured information based natural selection principles survival allows combination solutions sequence generations leading best solution findings standard experimental design methodologies proposed approach shows advantages finding optimal conditions imposed constraints indeed quality produced surface roughness evaluated using criterion method determines combined effects input parameters optimal machining parameter originality value new methodology determining optimal machining parameters dry turning based measurement surface roughness proposed numerical experimental developed model used success applications industrial interest
present study explores preparation characterization role phenolic acid fibrous protein management induced oxidative stress studied vitro conditions brief prepared engineering fibrous protein phenolic acid moieties subjected characterization ensure resultant studied efficacy free radical using cells induced oxidative stress also agent cell migration using fibroblasts cells results revealed induced oxidative stress cells exposure radiation managed prepared reducing levels superoxide anion oxygen hydroxyl radicals protein phenolic acid interaction supports cell migration evidenced scratch assay conclusion though phenolic acids known antimicrobial antioxidant potential acids directly wounds protein explored scavenging activity expected present study phenolic acid engineered protein significant role managing imbalance redox state prevailing wounds supports healing level elsevier rights reserved
national science foundation sponsored project initiated department mechanical manufacturing engineering university aim creating online learning modules increase efficacy modules designed computational experimental analysis grouped along five thematic lines form subject modules contain multimedia content designed use supplementary course material independently students preparation research tasks review specific concepts prior courses used augment existing courses salient feature modules ability introduce lab experiment derived content lecture course formats found particularly effective engaging students enabling introduction new topics minimal disruption existing daily course projects development implementation phase end mid year since assessment continuous improvement integral parts project paper presents data two year assessment process describes changes project paper also includes discussion plans expansion modules practices keeping content current
large scale rainwater harvesting promising alternative address security flood issues urban areas development planning eco community involves comprehensive site planning systems planning design includes rainwater source collection roof storage tank distribution allocation system paper describes new technique designing community houses average persons per house average total daily water demand found optimal size storage tank roof area reliability application model case study revealed significant water saving total cost system life span years elsevier rights reserved
background genome wide association studies identified several common risk loci schizophrenia parallel neuroimaging studies shown consistent findings widespread white matter patients methods examined role genes brain connectivity patients combining transcriptional profiles risk genes identified recent genome wide association study schizophrenia working group psychiatric genomics consortium data connectivity reductions patients expression profiles psychiatric genomics consortium risk genes extracted human brain atlas average profile across cortex correlated pattern cortical derived diffusion weighted magnetic resonance imaging data patients matched healthy controls results expression profile risk genes across cortical regions significantly correlated regional addition effects found potentially specific transcriptional profiles related cortical patients bipolar disorder diffusion weighted magnetic resonance imaging data patients controls examination correlations across genes present human brain atlas showed set top strongest correlating genes display significant enrichment disorder potentially identifying new genes involved pathophysiology conclusions results suggest disease conditions cortical areas pronounced expression risk genes implicated form central areas white matter
article seeks explore relationship among three individual level trait measures masculinity two aspects intimate partner violence ipv physical violence control sample heterosexual men court mandated treatment program results indicate aspects masculinity specifically hostile contribute use controlling tactics intimate relationships furthermore implications findings suggest failure achieve desired control lead use physical violence inconsistent past findings limited study clinical populations examination concepts provides increased understanding mechanisms behind ipv results provide greater understanding complexity violence better assist individuals experiencing ipv
although hyperglycemia common neonates especially preterm infants diagnosis neonatal diabetes mellitus rarely made permanent transient mutations methylation defects account majority two cases transient extremely preterm weeks gestational age due missense mutation gene presented patients successfully insulin months age comprehensive genetic testing targeted next generation sequencing methylation analysis helps identify diabetes early thereby improving metabolic glycemic control patients potassium channel mutations started treatment
older women pre fracture slow walk speed high body mass index high level significantly higher health care costs hip fracture compared without characteristics studies investigate targeted health care interventions individuals reduce hip fracture costs warranted aim study estimate associations individual pre fracture characteristics total health care costs hip fracture using study osteoporotic fractures cohort data linked medicare claims study population women age older enrolled medicare fee service experienced incident hip fracture january december assessed pre fracture individual characteristics study visits estimated costs hospitalizations skilled nursing facility inpatient rehabilitation home health care visits outpatient utilization medicare claims used generalized linear models estimate associations predictor variables total health care costs hip fracture median total health care costs year hip fracture inter quartile range multivariable adjusted total health care costs year hip fracture higher walk speed compared higher body mass index compared higher seven compared comorbid medical conditions pre fracture poor mobility obesity multiple comorbidities associated higher total health care costs hip fracture older women studies investigate targeted health care interventions individuals reduce costs hip fractures warranted
paper method proposed realize grid multi chaotic system current feedback operational amplifier firstly nonlinear circuit designed based grid multi chaotic circuit designed relevant circuit parameters calculated finally circuit simulation conducted results show circuit higher central frequency needs less components possesses simpler circuit structure good frequency characteristic port characteristic
correlations early late efficacy endpoints assessed identify potential surrogate endpoints overall survival progression free survival clinical trial level data three non hodgkin lymphoma subtypes diffuse large cell lymphoma follicular lymphoma cell lymphoma one hundred eight phase iii trials trial arms identified included database correlations efficacy endpoints analyzed using weighted linear regression pearsons coefficient determination newly diagnosed month strongly correlated year confidence interval six month strongly correlated year moderately correlated year trials linear regression determined increase month yield increase year increase year increase year month complete response rate moderately correlated median trials respectively six month potential surrogate endpoint year newly diagnosed year month rate potential surrogate endpoints median patients confirmation validation correlations facilitate early interpretation trials
shape memory materials type smart material potential applications sensors aerospace engineering medical devices study prepared rubber high density polyethylene composites continuous architecture simple physical blending method shape memory composites two temporary shapes using different melting points natural rubber addition peroxide architecture rubber composites critical materials properties component forms three dimensional network good properties two components combined results showed memory behavior composites dependent degree composites physical mechanical properties rubber composites improved exhibited excellent shape memory behavior better values shape ratio shape recovery ratio crystalline phase rubber composites almost completely resulted one temporary shape memory behavior composites society chemical industry
coping strategies exert important influence development course substance use disorder sud major depressive disorder mdd treatment outcomes examined coping related treatment sud sud mdd patients associations clinical characteristics forty sud sud mdd males group composed therapeutic community ambulatory treatment patients assessed coping strategies inventory clinical characteristics questionnaires sud mdd patients scored higher strategies social withdrawal lower engagement ones problem solving cognitive social support self perceived capacity coping differences treatment found sud specially sud mdd patients scored higher norms maladaptive strategies time abstinence age onset severity sud related maladaptive coping sud sud mdd patients prone employ coping strategies sud mdd patients coping maladaptive sud ones likewise clinical characteristics associated maladaptive coping differ diagnosis modality treatment male patients findings considered treatment design improve recovery prevent relapses
background myeloproliferative neoplasms mpn group blood cancers boost normal blood cell production bone marrow abnormal mutations stem cells found accompanying occurrence mpn shown mpl mutations mpl mpl involved patients mpn since tyrosine residues mediate normal mpl signaling whether affect mpl induced myeloproliferative neoplasms mpns unknown results study tested functions mpl induced myeloproliferative neoplasms mpns either mpl termed respectively vitro retained ability induce independent proliferation increase colony forming unit cfu accordingly differential activation downstream signaling four mutants observed constitutively active akt instead partially compensated function support deficiency impaired mpl induced cfu expansion vivo induced typical features mpns high platelet counts splenomegaly bone marrow surprisingly also caused bone marrow splenomegaly without significant features also observed differential effects four mutants progenitors myeloid cells conclusions studies revealed distinct features tyrosine sites mediating mpl induced mpns study also suggests mpl cytosolic phosphorylated flanking amino acids become targets pharmacologic inhibition mpns
background measured interval heritable prolongation established risk factor several cardiovascular diseases yet genetic studies performed european populations possibly reducing global relevance objective leverage diversity improve biological insight fine mapped previously identified loci populations african american hispanic latino methods racial ethnic specific multiple linear regression analyses adjusted heart rate clinical covariates examined separately combination inverse variance weighted trans ethnic meta analysis results fine mapped represented independent signals significantly finally bioinformatics based functional characterization suggested regulatory function cardiac tissues majority independent signals generalized novel snps conclusion findings suggest majority identified snps gene regulatory dysfunction prolongation loci influence variation across global populations additional novel population specific signals exist
investigate full scale wind induced vibrations long span suspension bridge central span long term wind wind effect monitoring system created basic wind field characteristics along span wise direction investigated bridge analyzed found wind field along span wise direction inhomogeneous full scale wind pressure distribution around lower surface twin box girder also obtained power density functions fluctuating pressures vortex shedding frequency full scale twin box girder determined field visualization test performed flow pattern around lower surface obtained thirty seven vortex induced vibration events observed monitoring period corresponding wind conditions vibrations analyzed detail addition wind direction inflow turbulence found wind field along span wise direction bridge also critical factor affects full scale bridge section model test full scale bridge compared found vertical amplitude section model much smaller field monitoring results moreover torsional appeared section model test whereas observed full scale bridge elsevier ltd rights reserved
paper reports design development reconfigurable point data parallel constant geometry fast fourier transform fft architectures based network chip paradigm factor realized using proposed architecture order ensure high throughput mapping fft functions cores done considering proposed signal flow graph sfg fft architecture helps optimizing design network components network interfaces reducing latency fft computation proposed input size aware architecture faults processing elements accomplish entire fft computation using one mapped onto mesh based proposed architectures achieve reduction latency compared several existing fft architectures hardware realization network components proposed architectures done using family field programmable gate array fpga device maximum operating frequency proposed architecture found mhz meets timing specifications several application standards addition fpga prototype proposed architectures also synthesized asic design flow obtain area power results elsevier rights reserved
interpersonal interactions action perceiving understanding actions others responding planning performing self made actions perception action self made observed ongoing motor responses iterative feedback within perception action loop fundamental phenomenon occurs within single cells brain demonstrate sensory motor response properties mirror neurons led research leading broadly accepted idea human mirror system current review examines putative human mirror system literature highlight several inconsistencies comparison data ongoing controversies within human focused research including mirror neuron origin function particular address often neglected side mirror complementary opposing actions propose engagement mirror system meeting changing task demands dynamically modulated via frontal control networks authors published elsevier ltd open access article license http creativecommonsorg licenses
human nonverbal communication computing aims investigate people exploit nonverbal aspects communication coordinate activities social relationships nonverbal behavior plays important roles message production processing relational communication social interaction networks impression management emotional expression fundamental yet challenging research topic effectively analyze nonverbal communication computing motion analysis methods widely investigated employed paper introduce concept applications nonverbal communication computing also review motion analysis methods employed area include face tracking expression recognition body reconstruction group activity analysis addition also discuss open problems future directions area published elsevier
exposure high levels glucocorticoids early life induces long lasting neuroinflammation induce rapid mast cells release proinflammatory molecules promoting activation microglia astrocytes possible involvement however remains poorly understood studied whether high levels gestation activates hippocampal mouse offspring control pups showed expression components caspase levels increased prenatal administration dexamethasone synthetic cells also showed high levels tnf revealing activation moreover showed increased levels receptor associated activation however levels either affected reduced nonetheless functional states elevated directly associated functional receptors observed treated brain slices activity first increased hippocampal mast cells later microglia induced activity releasing hormone receptor agonist response inhibited blocker mast cells microglia inhibitors increase activity persisted several weeks birth cross fostering control mother reverse condition proposed activation relevant demyelinating diseases associated early life exposure high levels wiley periodicals inc
problem direction arrival estimation non circular signal non uniform linear array investigated generalised algorithm treated improvement algorithm inter elements spacing array geometry uniform non uniform within half wavelength authors combine algorithm property propose algorithm obtain signals requires spectrum peak searching moreover computationally efficient search free root algorithm based polynomial also proposed computational cost proposed algorithms much better estimation performance conventional algorithm detect sources sensors due property furthermore proposed algorithms work without estimating phase effectiveness improvement proposed algorithms proved following simulation results
purpose purpose paper investigate relationship pre training competencies productivity workplace design methodology approach analysis authors use firm level data oral writing competencies competencies basic mathematics information technology problem solving authors productivity school competencies include number firm specific control variables reducing authors data set firms one authors transform firm level data quasi data findings main findings competencies equally related productivity problem solving competencies followed oral writing competencies show strongest relation productive potential competencies also positively weakly related productivity contrast higher levels basic mathematical competencies leave productivity levels largely unchanged differentiating occupational groups authors find positive relation competencies productivity predominantly exists commercial rather industrial technical practical implications results show better school competencies associated higher productivity turn lowers firms training costs policy perspective finding important implies improving competencies firms willingness participate system increased moreover results important training firms show competencies firms focus recruitment decision originality value paper studies first time relation pre training competencies productivity working place practical implication authors analysis useful implement tools measuring problem solving oral writing competencies process recruitment
memory unreliable example reading new baby stayed night people often new baby night similarly hearing bed rest people often remember sleep list roediger mcdermott general false memories difficult correct despite additional study opportunities argue errors first detected corrected consistent argument two experiments showed false memories nearly eliminated conditions facilitated comparisons participants errors corrective feedback immediate trial trial feedback allowed direct comparisons responses correct information however knowledge made error insufficient unless feedback message also contained correct answer rate false memories remained relatively constant one hand special correcting false memories simply labeling error wrong also insufficient correcting memory errors including facts however unlike types errors often benefit spacing afforded delayed feedback false memories require special consideration learners fail errors unless correction conditions specifically highlight
effective way learn computer programming side side front computer peer write code together discuss happens code bring kind person interaction online setting developed multi user web based program visualization system enables multiple people write code together explore automatically generated visualization execution state using multiple mouse via embedded text box nine months live deployment educational website people cities across countries participated sessions collaborative learning sessions connected participants different cities different countries participants actively engaged program visualizations showed affective exchanges indicated signs learning lower three levels taxonomy remembering understanding applying knowledge
calculate radiative properties spectral energy distribution variability radio infrared images using first physically motivated black hole directly evolve electron thermodynamics general simulations models reproduce coupled disc jet structure emission previous phenomenological analytic numerical works specifically find low frequency radio emission dominated emission polar outflow emission ghz dominated inner region disc latter produces time variable near infrared nir ray emission frequent events including without corresponding ray weak ray photon ring clearly visible ghz encouraging future horizon scale observations also show anisotropic electron thermal conduction along magnetic field lines negligible effect radiative properties model conclude limitations current generation first principles models particularly outflow closer isothermal thus low frequency radio emission
targeting receptor results mutant mouse model amyotrophic lateral sclerosis als neuroprotective effects receptors facilitated upregulation spinal cord mutant mice investigated whether similar receptor upregulation parallel changes elements evident spinal cord dogs degenerative caused mutations superoxide dismutase gene used characterized post mortem spinal unaffected affected dogs tissues used first confirm loss motor neurons using staining accompanied glial reactivity elevated immunoreactivity next investigated possible differences expression genes measured qpcr affected control dogs found changes expression receptor confirmed receptor immunostaining enzymes contrast receptor levels significantly elevated affected dogs determined qpcr western blotting confirmed grey matter using receptor immunostaining using double labelling immunofluorescence receptor indicating upregulation receptors astrocytes affected dogs results demonstrate marked upregulation receptors spinal cord canine concentrated activated astrocytes receptors used potential target enhance neuroprotective effects exerted glial cells
paper extend figures merit class symmetrical fully differential case compare topologies literature analysis shows power consumption significant role determining efficiency ota hand needed set desired output common mode voltage improve propose complementary applied current suitable class symmetrical show case studies deep cmos technology assess effectiveness proposed solution copyright john wiley sons ltd
eczema frequent childhood manifestation atopic children allergic certain foods anxious parents atopic children often fear topical steroid related side effects try range elimination diets avoid allergies elimination diets increase risk anaphylaxis exposure previously tolerated foods loss oral tolerance unbalanced diets together excessive consumption fruits vegetables lead plant foods benign unusual diets consumption vitamin health supplements lead vitamin toxicity discuss child eczema exclusion diet presenting anaphylaxis dairy food resolved dietary management
water plays central role plant biology efficiency water transport throughout plant affects photosynthetic rate growth influence scales productivity terrestrial ecosystems moreover hydraulic traits mediate ways plants interact abiotic biotic environment landscape global scale plant hydraulic traits important describing function ecological communities ecosystems plant hydraulics increasingly recognized central hub within network plant biology connected community ecosystem ecology earth system science challenges mitigating impacts climate change improving security sustainability food supply rely fundamental knowledge water behaves cells tissues organs bodies diverse communities plants workshop emerging plant hydraulics supported national science foundation held promote open discussion new ideas controversies regarding measurements analyses especially potential expansion scaled scaled inter disciplinary research strengthening connections plant hydraulic research fields global modelling efforts plant hydraulics increasingly recognized central hub relating fields within plant biology ecology evolution agriculture essential challenges mitigating impacts climate change improving security sustainability food supply workshop entitled emerging plant hydraulics supported national science foundation held summarize discussions including controversies regarding measurements analyses emerging scaled scaled inter disciplinary research strengthening connections research plant hydraulics fields global modelling efforts
sediment transport important aspect soil erosion sediment transport capacity key establishing process based erosion models lot studies exist determined flow however studies conducted determine sediments steep slopes experimental data region thus needed objectives study formulate new equations describe evaluate suitability equations sediments steep slopes slope gradients study ranged flow discharges per unit width varied results showed increased power function flow discharge slope gradient nash model efficiency sensitive flow discharge slope gradient increased power function mean flow velocity satisfied predict shear stress also good predictor stream power better predictor shear stress however unit stream power good predictor estimate study findings offer new approach predicting sediments steep slopes elsevier rights reserved
purpose study evaluate locus control predicts various quality life qol mental measures among cancer patients time palliative care multi site analysis patients advanced cancer seen new patients palliative supportive care outpatient clinic patients completed following surveys locus control scale functional assessment chronic illness therapy general fact functional assessment chronic illness therapy spiritual hospital anxiety depression scale hope index regression models created examine effect upon qol symptoms measures mental models adjusted effect age gender race partnership status education months since diagnosis potential confounders study enrolled patients adjusting site race partnership status higher levels chance predicted decreased qol fact higher levels chance also correlated increased depression anxiety decreased meaning additionally higher levels chance predicted decreased hope cancer patients high chance risk decreased physical mental end life efforts made identify patients design interventions increase feeling control situation order improve physical mental end life
acute myeloid leukemia aml characterized proliferation immature myeloid lineage due heterogeneity high rate acquired drug resistance relapse new treatment strategies needed demonstrate ifn promotes aml act effector cells within context antibody therapy treatment ifn aml toward differentiated state wherein showed increased expression related markers hla mediates effector responses therapeutic antibodies importantly ifn able regulate target therapeutic antibody antigen effector receptor simultaneously regulated aml tested whether ifn treatment aml cell lines stimulate target one another addition results showed ifn significantly increased mediated cytotoxicity measured release lactate dehydrogenase release assays also found combination ifn activation led release aml cells finally using murine model subcutaneous aml found treatment ifn plus significantly attenuated tumor growth taken together studies show novel mechanism mediated killing possible new therapeutic strategy aml
background ratios digit lengths studied intensively markers prenatal sex hormone levels aim study sexual ratios received less attention methods studied six ratios human fetuses ages weeks results conclusion found indication sexual early stage development elsevier ireland ltd rights reserved
first generation antipsychotic belonging class recently lower dose producing inhaled powder directly administered lungs treat associated psychiatric disorders schizophrenia bipolar disorder thus aim narrative clinical mini review evaluate efficacy tolerability inhaled treatment acute patients psychiatric disorders efficacy inhaled evaluated one phase trial patients schizophrenia two phase iii trials patients schizophrenia bipolar disorder moreover two published case series patients borderline personality disorder dual diagnosis patients inhaled proven effective generally tolerated administered patients schizophrenia bipolar disorder two case series suggested inhaled also useful treat patients borderline personality disorder dual diagnosis studies needed clarify point however administration inhaled requires least kind patient collaboration recommended treatment severe totally patients moreover drug related risk always kept mind planning use inhaled leading careful patient assessment prior administration also higher costs inhaled compared oral medications taken account selecting treatment
noise unstable power supply influence sensing results classic charge transfer based capacitive touch sensing methods sensing methods implemented devices share power supply heavily changing loads sensing methods inclined fail paper proposes inverse charge transfer sensing method applied low power quality situation proposed method includes reference channel sensing capacitors sensing channels reference channel terminal voltage therefore inconsistencies sensing results induced low power quality compensated using reference channel experimental result indicates proposed method exhibits excellent touch signal noise ratio improvement switching noise case case able distinguish state case
purpose patients rheumatoid arthritis osteoarthritis require revision total knee replacement studies compared post operative complications results risk revision patients material methods forty five patients undergone revision selected matched patients revision period results use revision implant osteoarthritis compared results use inflammatory arthritis mean follow ten years range years determined differences comorbidities risk peri operative adverse events functional radiological results risk subsequent revision patients suffering versus results higher comorbidities post operative days adverse events mortality average ten years patients mean overall changes function scores greater revision group compared revision group taking steroids regression methotrexate tnf alpha blockers regression significant factors lines average ten years patients undergoing revision likely revision among patients patients undergoing revision department patients conclusions similar results knee observed two forms arthritis spite fact initial local joint status general health status worse inflammatory rheumatoid arthritis degenerative osteoarthritis however complications frequent
background existing literature suggests presence possible relationship high anger levels smoking behavior however available data highlighting possible differences moderate heavy smokers putative effect gender smoking behavior objectives aims current study assess relationship among anger depression anxiety smoking patterns taking account possible mediator role gender methods smokers volunteers recruited staff university italy final sample consisted smokers divided heavy smokers cigarettes per day moderate smokers cigarettes per day subjects assessed state trait anger expression inventory self rating depression scale self rating anxiety scale results anger depression anxiety measures group scored higher groups showed higher expected levels trait anger greater tendency control anger reactions access anger management techniques moderate consumption cigarettes cigarettes per day associated negative emotions showed higher expected levels state anger cigarettes consumption related gender specific anger features conclusions importance study highlighted importance anger smoking behavior related gender differences recognizing link among anger gender differences smoking behavior improve knowledge future focused interventions smoking cessation
paper presents four analog multiplier using dual second generation current proposed multiplier employs two eight mos transistors operating saturation region ideal monolithic implementation use mos devices operating saturation region offers high frequency capability circuit pspice simulators using tsmc cmos process used validate circuit simulation results show circuit bandwidth mhz total harmonic distortion input current
use manufacture attracted worldwide interests aim paper present overview progress research development china last years works mechanisms microstructure development properties application development green building material thermal resistant material advanced inorganic composites ceramics reviewed works published many chinese made significant contribution progress science technology whole global view latest experimental results phase transformation discussed two key issues regarding application based elsevier rights reserved
funding bodies tended encourage collaborative research generally highly cited sole author research higher mean citation collaborative articles imply collaborative researchers general research productive article assesses extent research productivity varies number collaborative partners long term researchers within three web science subject areas information science library science communication medical informatics using whole number counting system researchers worked groups generally productive terms producing papers citations however using fractional counting researchers worked groups generally productive findings need interpreted however authors produce academic articles within field fields leave academia contribute society ways
practice parameter intended guide appropriately trained licensed physicians performing therapy sources therapy requires close cooperation communication physicians responsible clinical management patient therapy manage side effects adherence practice parameter help maximize efficacious use procedures maintain safe conditions ensure compliance applicable regulations goal therapy sources provide either cure effective disease minimizing side effects complications
schizophrenia research enormous challenges integrating analyzing large datasets difficulties developing formal theories related etiology pathophysiology treatment disorder computational psychiatry provides path enhance analyses large complex datasets promote development refinement formal models features disorder presentation introduces reader notion computational psychiatry describes discovery oriented theory driven applications schizophrenia involving machine learning reinforcement learning theory informed neural circuit models
analytic two dark soliton solutions variable coefficient nonlinear schrodinger equation obtained via modified hirota method parallel solitons observed soliton control soliton compression realized different group velocity dispersion profiles besides soliton interactions investigated interaction distance adjusted addition soliton structures attractive ones obtained exponential dispersion profile results research useful soliton control inhomogeneous optical fibers benefit realistic optical communication systems elsevier ltd rights reserved
patients schizophrenia show specific abnormalities visual perception patients bipolar disorder related perceptual deficits tasks highlight perceptual dysfunction patients schizophrenia show abnormal activity visual brain areas including lateral occipital complex early cortex unclear whether anatomical structure visual areas atypical schizophrenia bipolar disorder members two patient groups healthy controls localized early cortex individually participant using functional magnetic resonance imaging mri measured thickness regions interest using structural mri scans regions patients schizophrenia cortex controls cortex bipolar patients intermediate cortical thickness control region motor cortex show pattern group differences thickness visual region interest significantly correlated performance visual object task schizophrenia patients findings suggest anatomical substrate visual processing abnormalities found neural behavioral measures schizophrenia severe mental illnesses
rationale tobacco higher rate dependence drugs abuse however effects nicotine incongruent tobacco addiction since nicotine produce robust humans self administration rodents potential explanation nicotine salience stimuli incentive value influence initiation persistence smoking however neural mechanisms process unknown objectives one way nicotine amplify salience stimuli enhancing reward prediction errors hypothesized nicotine enhance neural response unexpected relative expected rewards compared placebo methods twenty three underwent two fmri scans following nicotine placebo administration performing outcome expectation task task pair cues associated either subsequent reward image image trials cue followed unexpected outcome results although nicotine affect magnitude prediction errors relative placebo nicotine increase activation anterior insula inferior frontal gyrus decrease activation across outcome types including rewards conclusions insula play role initial effects nicotine changes baseline mechanism underlies nicotine salience stimuli
considerable evidence suggests adolescent exposure delta component increases risk developing schizophrenia related symptoms early adulthood present study used combination behavioral molecular analyses vivo neuronal electrophysiology compare long adolescent versus adulthood exposure rats report adolescent adult exposure induces long term neuropsychiatric like phenotypes similar observed clinical populations thus adolescent exposure induced behavioral abnormalities resembling positive negative schizophrenia related state neuronal hyperactivity dopamine pathway furthermore observed profound alterations several prefrontal cortical molecular pathways consistent sub cortical dysregulation findings demonstrate profound dissociation relative risk profiles adolescent versus adulthood exposure terms neuronal behavioral molecular markers resembling neuropsychiatric pathology
novel generalized pattern search gps based cellular automata gps model developed simulate urban land use change gis environment model built fitness function computes difference observed results produced remote sensing images simulated results produced general model gps optimization incorporating genetic algorithms gas searches minimum difference smallest accumulated fitting transition rules coefficients captured gps method clear physical meanings closely associated dynamic mechanisms land use change gps model applied simulate urban land use change city yangtze river delta results show gps method smaller root mean squared error logistic regression method fitting transition rules gps model thus outperformed model overall accuracy improvement result gps model superior tool modeling land use change predicting future scenarios response different conditions support sustainable urban development
recent improvements described open source finite element software shown highly efficient option electrical machine modeling parallelization computational burden shown necessity methods implemented enable applying fully parallel computation electrical machine models including rotation electrical circuits computational experiments performed demonstrate effectively utilize several hundreds computational cores parallel making attractive alternative computational speed high importance
telomere length analysis greatly simplified quantitative flow cytometry technique fish flow method labeled synthetic oligonucleotide complementary telomere terminal repeat sequence telomere sequence resulting fluorescence measured flow cytometry technique traditional southern blot telomere length measurement techniques many laboratories allows single cell analysis telomere length high throughput sample formats nevertheless harsh conditions required telomere probe annealing degrees made difficult successfully combine technique simultaneous traditional organic fluorescent probes etc limited thermal stability survive high temperature annealing process despite efforts covalently antigen antibody complex loss probe fluorescence made difficult measure fish flow complex lymphocyte populations generally forced investigators use fluorescent activated cell sorting pre separate populations technique requires large numbers cells study substituted quantum dots nanoparticles traditional fish flow quantum dots demonstrated possess much greater thermal stability traditional low molecular weight quantum dot antibody conjugates directed monocyte cell antigens found retain fluorescence following high temperature annealing step allowing simultaneous fluorescent telomere length measurement since quantum dots narrow emission able analyze multiple quantum dot antibody conjugates simultaneously fish flow measurement assess age associated decline telomere length human monocytes cell subsets quantum dot mean decrease rate telomere length cells calculated year close previously reported values using traditional flow fish southern blotting modification traditional flow fish technique therefore allow simultaneous fluorescent telomere length measurement complex cell subset specific analysis small numbers cells without requirement prior cell sorting published elsevier
important determine mechanical properties reinforced soils since extensively used practice study laboratory tests direct shear tests carried order determine stress strain dilation characteristics geotextile reinforced river sand mechanical behaviour composite material investigated varying type geotextile pressure interface properties geotextile reinforced samples evaluated direct shear tests results demonstrated geotextile inclusion increases peak strength reduces dilation especially higher pressures
amyotrophic lateral sclerosis als disease neurons recently identified mutations common causes consecutive series familial als japan reveal possible genetic causes remaining patients familial als performed targeted next generation sequencing known als motor neuron diseases related genes known variants identified patients novel likely pathogenic homozygous variant identified patient addition patients whereas repeat expansions detected using repeat primed polymerase chain reaction collectively japanese cohort frequencies respectively findings indicate considerable differences genetic variations familial als across populations genetic analyses functional studies novel variants warranted elsevier inc rights reserved
aim study investigate reasons adult learners took longer required complete degrees questionnaire focus group interviews used collect data twenty adult learners registered degrees one campus university targeted responded participants lived obtained primary secondary tertiary education schools found lack computer skills poor research skills inadequate access internet stress supervision problems workload contributed adult learners inability complete studies within prescribed period study also highlighted impact education adult learners level education system characterised poor education provision played major role slow completion degrees african adult learners recommended african adult learners degrees training research approaches computer skills information search stress management prior study study duration degrees also need reviewed especially adult learners students obtained education schools
paper describes laboratory testing investigate suitability recycled construction materials alternative materials permeable permeable increasingly used urban stormwater management systems three commonly found recycled waste materials recycled concrete aggregate asphalt pavement investigated assess suitability permeable pavement materials geotextile also used research trap pollutants laboratory tests included basic physical characterization particle size distribution specific gravity water absorption los california bearing ratio modified tests addition hydraulic conductivity tests undertaken laboratory test setup different suspension percentages moisture contents temporal variations effluent suspension percentages investigated assess effects found geotextile layer effect terms permeability materials chemical assessment included organic content value trace element concentration range contaminant constituents compared maximum limits soil natural water environmental protection authorities requirements terms geotechnical chemical assessment permeable pavement applications found suitable alternative construction material permeable borderline meet specified requirements american society civil engineers
accurate measuring systems past years based laser laser able acquire information directly precisely real time however comparing conventional cameras kinds equipment usually expensive commonly available customers moreover laser interfere easily sensors type hand computer vision based measuring techniques use stereo matching acquire cameras relative position estimate location points image kind systems needs additional estimation information systems real time capability often relies heavy parallelism prevents implementation mobile devices inspired structure motion systems propose system sparse feature points point cloud using mono video sequence achieve higher computation efficiency system keeps tracking detected feature points calculates amount feature points moving distances use key frames estimate current position camera order reduce computation load noise interference system furthermore avoiding duplicate points system point point shifts boundary camera experiments show system able implemented tablets achieve state art accuracy point cloud high speed
integrated model simulating diagnosing water quality based system dynamics bayesian network presented paper research aims connect water monitoring downstream outlet management upstream order present efficiency outlet management strategy integrated model built two components system dynamics used simulate water quality applied diagnose reason water quality deterioration according water quality simulation integrated model applied case study river section section prove accuracy results showed simulation fit variation trend monitoring data average relative error less water quality deterioration section mainly found caused water quality upper reach reservoir drain using diagnosis function integrated model based relevant result revealed integrated model provide reasonable quantitative support basin manager make reasonable outlet control strategy avoid serious water quality deterioration
contribution efficient multiscale computational formulation developed geometric nonlinear analysis heterogeneous piezoelectric materials formulation relations microscopic heterogeneous properties macroscopic behaviors piezoelectric composite established numerically constructed displacement electric potential base functions heterogeneous complex microstructure equivalent simple macroscopic piezoelectric coarse element constructed multiscale base functions equivalent stiffness matrix internal force vector macroscopic coarse element deduced based rotational approach describe motion macroscopic coarse element clearly efficiently thus original electro mechanical coupling geometric nonlinear problem solved iteratively macroscopic scale save tremendous amount computing time cost macroscopic calculations microscopic mechanical electrical responses retrieved calculated macroscopic solutions using mentioned multiscale shape functions verify validation high efficiency proposed multiscale computation formulation several typical numerical examples carried computation results indicate developed multiscale formulation provide high precision solutions also high efficiency elsevier ltd rights reserved
paper multistage susceptible infectious recovered model distributed delays nonlinear incidence rate investigated extends model considered global dynamics general class multistage models infectious diseases appropriate realistic conditions global dynamics completely determined basic reproduction number infection free equilibrium globally asymptotically stable disease stages unique endemic equilibrium exists globally asymptotically stable hence disease persists stages results proved utilizing theory non negative matrices lyapunov graph theoretical approach copyright john wiley sons ltd
hiv continues impose enormous morbidity mortality economic burdens across globe simultaneously innovations antiretroviral therapy diagnostic approaches vaccine development providing novel tools treatment prevention prophylaxis developed mathematical model evaluate added benefit hiv vaccine context goals increase rates diagnosis treatment viral suppression countries status interventions predict median million first third incident cases globally achieving joint united nations program hiv aids target estimated million new infections additional million reduction projected introduction efficacy vaccine gradually scaled coverage added benefit prevention vaccination motivates ongoing clinical trials viable candidates realize goal hiv control
psychological warmth serves fundamental dimension human social cognition impressions groups assessments warmth comprise elemental building block social perception using guiding framework research demonstrated perceptions others along warm cold dimension elicited sensory experiences physical warmth show effects kind also triggered mentally simulating physical temperature certain theoretically important imagery conditions specifically impressions target impacted warmth thinking holding hot coffee event simulated first person perspective effect emerged third person orientation adopted finding underscores functional nature mental simulation identifies spatial visual perspective critical boundary condition embodied cognition elsevier inc rights reserved
paper provides overview development long span bridges monitoring japan emphasis monitoring strategies types monitoring system effective utilization monitoring data severe environment condition high seismic activity strong wind bridge monitoring systems japan historically put emphasis structural evaluation extreme events monitoring data used verify design assumptions update specifications facilitate efficacy vibration control system among first objectives instrumentation long span bridges framework monitoring system japan later monitoring systems also utilized evaluate structural performance various environment loading conditions detect possible structural deterioration age structures monitoring systems also employed basis investigation decision making structural repair required recent interest extend application monitoring facilitate operation maintenance risk asset management utilizing monitoring data paper describes strategies several examples monitoring system lessons learned structural monitoring long span bridges japan
longitudinal harvested rainwater quality monitoring study undertaken sites within malaysia period months overall harvested rainwater good quality falling within recreational water quality class standards ammonia total large number samples tested positive escherichia coli total showing harvested rainwater mandatory prior reuse harvested rainwater samples exceeded lead limits drinking water standards showing consuming rainwater without additional treatment pose health risk mixing harvested rainwater groundwater resulted higher total rainwater collected wet seasons higher concentrations suspended solids turbidity escherichia coli dry seasons due antecedent dry period last least principal component analysis positive matrix conducted samples pollutant sources harvested rainwater principal components identified namely industrial dust steel dust organic decay results principal component analysis positive matrix agreement although latter identified water top additional factor responsible dissolved solids techniques effective pollutant sources harvested rainwater show rainwater harvesting system designed carefully reduce contributions steel organic decay industrial dust dust elsevier ltd rights reserved
goal paper validate model order determine pay adjustment basis mechanical functional performance transportation infrastructures model determine pay adjustment based life expectancy pavement variability main properties formulated five different paths points view used order obtain information model suitability robustness algorithm proposed estimate pay adjustment negative positive based life cycle cost analysis structural non structural deficiencies characteristics detected five different methodologies used deriving demonstrate validity model depends position dispersion measures demonstrated model help analysing project construction management common framework analyses validation demonstrate proposed model efficiently overcome typical problems determination contract administration decisions based upon objective sound criteria needed practitioners researchers expected benefit outcomes study
pursue study effective real time feedback technology enhanced learning developed presentation tool designed support practice nonverbal communication skills public speaking tool tracks users voice body analyze performance type real time feedback presented paper describes empirical study tested effects presentation feedback learners used tool practicing pitch results study reveal feedback significant effect learners motivation confidence self awareness performance
many psychiatric behavioral disorders manifest childhood attention deficit hyperactivity disorder obsessive compulsive disorder anxiety depression schizophrenia autism spectrum disorder etc opportunity early attenuate full development disorder long term disability yet pediatric drug cns indications limited pediatric testing generally occurs establishing adult efficacy rather initial goal developing medication pediatric cns indication pharmaceutical companies decreasing funding neuroscience research overall prospects moving promising drugs forward pediatrics decline goal review highlight important challenges around pediatric drug development psychiatric disorders specifically clinical development present opportunities filling gaps using new strategies drugs new clinical trial designs models first present current trends pediatric drug efficacy testing academic research industry trials discuss regulatory landscape pediatric drug testing including policies intended support encourage testing obstacles remain presented followed new designs funding opportunities considerations testing drugs safely published elsevier ltd
liquid quantum dots used fluorescent films sensor constructing macroscopic responsive liquid system lysine challenging task achieve selective macroscopic response towards herein present new strategy integrating host chemistry liquid system water soluble designed synthesized host introduced onto surface modified host interactions obtain liquid interaction stronger peg causing released surface presence resulting macroscopic fluorescence quenching smart material shows promise amino acid sensing separation
green building actively promoted many countries become mainstream chinese construction industry due various reasons paper aims investigate major driving factors development reference chinese construction market twenty one factors influencing development identified literature review questionnaire survey face face interview professionals construction industry structural equation model established identify critical driving path three critical factors hierarchies result model analysis also verifies theoretical hypotheses government body biggest motivation development path coefficient high results demonstrate necessity formulation incentive policies power identify distinct government market effects induce government led development path findings provide valuable reference government body aiming promoting construction industry put forward relevant policies incentives market body understand major driving factors path making decisions
two wave survey study investigated concurrent longitudinal relationships different styles restrictive active parental mediation autonomy supportive controlling inconsistent adolescents media violence exposure aggression sample consisted adolescents years girls results indicate restrictive mediation communicated autonomy supportive style concurrently related decreased aggression via decreased media violence exposure contrast inconsistent restrictive mediation concurrently related increased aggression via increased media violence exposure significant relationships found controlling restrictive mediation none restrictive mediation styles longitudinally related media violence exposure aggression active mediation moderated neither concurrent longitudinal relationships media violence exposure aggression regardless style used findings suggest autonomy supportive restriction effective route parents concerned childs media violence exposure aggressive behavior elsevier ltd rights reserved
psoriasis chronic relapsing autoimmune disorder skin affecting general population approximately psoriasis patients also affected psoriatic arthritis chronic inflammatory spondyloarthritis review aims present current knowledge diseases emphasize involvement various helper cell subsets extensive literature search electronic databases performed topic different cell subsets involvement pathogenesis psoriasis psoriatic arthritis studies assessed selected present recent progress area current data strongly suggest pso psa cell mediated diseases key role various proinflammatory cytokines development involvement cells highlighted superior efficacy biologic therapies targeting cell derived proinflammatory cytokines diseases initially pso psa thought mediated diseases however last years several studies shown important role cell subsets including treg cells pathogenesis diseases led development new therapies
background efficacy disease management programs improving outcome heart failure patients remains uncertain vary across health systems study explores whether disease management program superior usual care reducing adverse health outcomes improving among community dwelling adult patients moderate severe chronic heart failure universal access advanced health care services technologies methods multicenter open label trial patients recruited hospitalization heart failure exacerbation community randomly assigned either disease management usual care disease management delivered multi disciplinary teams included coordination care patient education monitoring disease symptoms patient adherence medication regimen titration drug therapy home monitoring body weight blood pressure heart rate patients assigned usual care treated primary care practitioners primary composite endpoint time till first hospital admission heart failure exacerbation death cause secondary endpoints included number hospital admissions health related quality life depression follow intention treat comparisons treatments adjusted baseline patient data study center results follow patients assigned disease management assigned usual care primary endpoint event median range time primary endpoint event end study years among patients assigned disease management years among patients assigned usual care adjusted hazard ratio confidence interval hospital admissions mostly unrelated heart failure patients assigned disease management better health related quality life lower depression score follow conclusions comprehensive disease management intervention superior usual care respect primary composite endpoint improved health related quality life depression disease centered approach make significant impact hospital admissions mortality patients chronic heart failure universal access health care
max plus linear systems studied almost three decades however established system theory specific systems still going research geometric control theory particular proposed future direction max plus linear systems max plus algebra system theory now annual reviews control article abstract theory traditional linear systems fields max plus linear systems new generalised version abstract theory provides concrete state space representation just set theoretic representation canonical transfer function also leads computational methods controlled invariant kernel equivalence kernel output map controlled invariant play key roles standard geometric control problems disturbance decoupling problem block decoupling problem network used illustrate main results article
background progress diagnostic assessment made possible diagnose asd young age concurrently intervention research toddlers asd increased since past decade method study report five level meta analysis single subject experimental studies intended offer better insight types interventions effective toddlers age three risk asd results analysis revealed significant positive overall effect size found interventions home significantly effective compared settings significant moderators regarding intervention characteristics agent intervention duration weeks moderator effects study child characteristics found conclusions average interventions toddlers risk asd successful elsevier ltd rights reserved
rapid eye movement sleep behavior disorder sleep disorder characterized ones sleep violent aggressive patients often come see doctor bed partners sleep prevalence based population much higher patients neurodegenerative diseases especially emergence decades used effective early marker neurodegenerative diseases pharmaceutical treatment includes melatonin newly reported medications review summarized clinical features pathophysiology therapy focusing correlation neurodegenerative diseases order emphasize significance early marker neurodegenerative diseases
important environmental processes zones release carbon nitrogen phosphorus various organic compounds extracellular enzymes soil microorganisms involved bio cycling organic matter nutrients important regulating water quality objectives present study determine whether activities soil enzymes affected different periods zone identify major factors influence soil enzyme activity subjected three study plots different conditions long moderate rare within perpendicular river flow three sites city china soil physicochemical properties dissolved nutrient composition soil enzyme activities analyzed activity acid phosphatase alkaline phosphatase significantly increased frequency decreased whereas activity beta glycine leucine dehydrogenase significantly higher study plots received long subjected moderate rare linear regression indicated hydrolase dehydrogenase activities affected soil clay content soil organic matter soil water content among factors limited activity acid phosphatase leucine glycine polyphenol oxidase activity constrained soil water content available potassium promoted study demonstrated imposing longer periods increase soil enzyme activities maintain microbial activity minimize water pollution important reduce high loads elsevier rights reserved
aim assess variability symptom presentation explanatory models psychosis people different ethnic groups methods clients first episode psychosis identified black african black white european recruited early intervention programmes hamilton compared results ethnic group symptom profiles explanatory models illness results clients black origin lower odds reporting speaking black african clients greater odds reporting persistent black african clients lower odds cause psychosis hereditary factors substance abuse lower odds assigning responsibility illness conclusions understanding differences illness models ethnic minority groups help improve cultural competence mental health services
aims objective study evaluate efficacy safety combined treatment agonist rock inhibitor rat model detrusor overactivity induced acetate rock inhibitor agonist administered single doses carried along measurement cardiovascular parameters combined use doses ineffective ameliorated increase found volume voiding efficiency volume threshold interval bladder compliance volume threshold elicit contractions accompanied decrease basal pressure threshold pressure detrusor overactivity index contractions amplitude frequency combination therapy question proved effect voiding pressure post void residual bladder contraction duration relaxation time observation female rats received show significant changes urine production increased heart rate blood pressure applied dose assessment combined treatment revealed significant drop cardiovascular parameters compared rats received combined use agonists rock inhibitors improve overactive bladder treatment efficacy minimize side appears improve urine storage impairment voiding function neurourol urodynam wiley periodicals inc
new model power assisted designed set tested main innovative solutions prototype described present paper electric motor position new mechanical transmission low cost measurement system driving torque special test rig differently common approach electric motor located one three idea prototype consists electrical motor central position means gear torque central hub innovative solution represented motion transmission motor shaft achieved two different first one second one simple gear prototype contains also new low cost measurement system driving torque based strain gauge load cell located one side wheel hub frame moreover commercial cycling simulator suitably modified order properly install different sensors measurement performance test rig able reproduce route paths acquired road tests measure performance terms instantaneous power speed experimental test rig simulate resistant torque predetermined track aims test optimize control strategy available electronic control unit authors also conducted environmental analysis developed particular comparing thermal terms environmental impact authors published elsevier ltd open access article license
study aimed assess diagnostic prognostic value anti mutated vimentin antibodies early rheumatoid arthritis vera established rheumatoid arthritis seventy one patients undifferentiated arthritis months duration established rheumatic diseases healthy individuals included study anti anti cyclic peptide antibodies rheumatoid factor determined hand radiographs recorded patients assessed prospectively years hand radiographs repeated diagnostic performance anti studied receiver operating characteristic roc curves evaluation sensitivity specificity likelihood ratios forty six percent patients progressed years vera patients sensitivity anti compared anti specificity compared anti anti detected vera patients negative anti established anti sustain diagnostic performance multivariable analysis anti anti showed significant correlation radiographic progression vera patients established anti anti associated active disease joint damage multivariate analysis strongest factors radiographic damage disease duration score conclusion patients early anti predict progression radiological damage therefore anti antibody testing useful every day practice
major advances made past years development integrated computational materials design technology hierarchical structure methods tools supporting fundamental materials databases reviewed emphasis successful applications calculation phase diagrams based tools example expressing mechanistic understanding quantitative form support science based materials engineering opportunities identified rapid expansion databases major materials education
anemia chronic inflammation frequently diagnosed anemia independently increased morbidity poor outcome associated multiple underlying diseases pathophysiology multifactorial resulting effects inflammatory cytokines directly indirectly suppress recent advances molecular understanding iron metabolism provide strong evidence immune mediators lead induced iron decreased iron availability role axis pathophysiology stimulating development new diagnostics targeted therapies review present overview rationale inflammation iron related strategies currently development
nuclear receptor car regulates hepatic drug energy metabolism cell fate activation critical factor drug induced toxicity development diseases including diabetes tumors car constitutive activity phosphorylation threonine utilizing receptor protein kinase regulatory subunit protein phosphatase threonine activate car demonstrate car undergoes monomer conversion regulate two differently tagged car proteins cells mouse primary hepatocytes mouse livers two dimensional gel electrophoresis revealed car form configuration binding site buried within dimer interface epidermal growth factor found stimulate car thus car inactive form ligand binds directly car phosphorylated car monomers exposing binding site car ligand binds receptor reversing signal car indirect activation thus monomer conversion underlying molecular mechanism regulates car activation placing phosphorylated threonine common target direct indirect activation car
last decade leadership energy environmental design leed rating system embodied efforts green building council recognize buildings designed achieve superior performance several areas including energy consumption given emergent interest improving buildings energy efficiency researchers generated predictive physical data driven models energy consumption although physical approaches aiming calculate energy consumption behavior building level accurate necessity continuously gathering data input parameters often makes approaches applications objective study introduce novel assessment method investigates correlation leed certification actual energy consumption investigating case study leed certified research buildings climate zone research approach first consists developing testing eight performance models non leed buildings fit best model five comparable leed certified buildings heating cooling electricity data collected buildings addition multiple weather time building characteristics variables data used generate several regression models predict energy consumption conventional research buildings results show differences energy use leed non leed buildings large anticipated paper contributes body knowledge first introducing novel generic assessment method leed buildings second applying method case study sample leed certified research buildings climate zone findings paper support actual performance assessment leed buildings helping practitioners make better decisions throughout project life order ensure fair representative assessment leed certification system future studies invited adopt new method comparing actual performance leed buildings non leed buildings american society civil engineers
paper proposes generic model analyzing microwave power sensor calibration direct comparison transfer model derived using signal flow graph together loop rule analyses proposed model investigated several case studies commonly encountered provides theoretical basis practical applications finally derived calibration equations practical cases also discussed
paper reviews recent literature mental health needs youth context war human rights lens used explore issues accessibility sustainability service utilization times crisis authors present evolution services last several decades progressing individual school based community wide interventions exploring models focus symptom reduction building resilience paper highlights benefits limitations traditional intervention methods proposes new intervention development research authors focus emerging field mental health services specifically highlight utility virtual reality games treating trauma exposed youth rapid easily accessible nature mental health models presented one potential solution barriers accessibility help promote human rights youth exposed war
goal improve initially fabricated ray optics figures applying magnetic field drive magnetic smart material msm coating non reflecting side mirror consequent deformation surface three dimensional report results working glass sample coated coated glass deformed dimensions surface profile measured white light driving magnetic field produced via pseudo magnetic write head made two permanent magnet magnet moved bottom glass sample computer controlled translation stage system allowed four degrees freedom motion side side back forth rotation diameter vertical axis allow change orientation magnetic field horizontal plane sample established finite element analysis fea model predict deformations compare observed results order guide application controlled improve future ray optics figures
human metabolism yields excreted conjugated urine publication sensitive selective analytical method described permits determination suitable parameter clean urine samples consisted steam solid phase extraction using reversed phase column internal standard converted excess reagent removed using silica gel separation quantitative analysis carried capillary gas chromatography mass selective detection coefficients variation concentrations detection limit method checked analysing six urine samples pest controllers indoor application concentrations ranged creatinine detected urine specimens non exposed persons sensitivity developed method permits detection latent exposure elsevier science rights reserved
present study examines molecular mechanism underlying vitro induced resistance susceptible strains albicans exposed like steroids progesterone beta est beta employing spot assays provide evidence vitro induced tested drugs accompanied concomitant increase transcript levels notably unlike isolates parental wild type delta null strains delta delta delta challenged display results validated northern blotting reporter gene transcription transcription run assays show vitro induced tested drugs inducer isolates mainly due transient reversible transcriptional activation earlier observation consistent high transcript levels clinical resistant isolates maintained due combination transcriptional activation enhanced mrna stability via poly study shows transient reversible transcriptional activation major determinant induced isolates distinct strategies sustained isolates transiently induced resistance mechanisms isolates adopted candida become useful improving therapeutic approaches
wireless sensor networks wsns collection several small inexpensive battery powered nodes commonly used monitor regions interests collect data environment several issues exist routing data packets wsn crucial problem energy number routing approaches wsns address issue energy use different energy efficient methods paper presents brief summary routing related issues wsns recent energy efficient data routing approaches reviewed categorized based aims methodologies traditional battery based energy sources sensor nodes conventional energy harvesting mechanisms widely used energy wsn reviewed new emerging energy harvesting technology uses piezoelectric supply power type sensors charged conventional energy explained energy consumption reduction routing strategies wsn also discussed furthermore comparisons variety energy harvesting mechanisms battery power routing protocols discussed presented eliciting advantages disadvantages specific feature finally highlight challenges future works research domain presented
therapies targeting inhibitory immune checkpoint receptors shown remarkable success many cancers patients benefit therapies catalyzed enormous interest targeting immune checkpoint receptors regard recently entered novel immune checkpoint receptor targets together receptor form pathway analogous pathway shared ligands differential receptor ligand affinities fine tune immune response although roles immune checkpoint receptors cell natural killer cell biology just beginning uncovered accumulating data support targeting receptors improving anti tumor immune responses clear understanding immune cell populations regulated key design target receptors combination existing immune checkpoint blockade therapies
background exposures prenatal period lasting effects maternal child health outcomes better understand effects utero environment childrens short long term health large representative pregnancy cohorts comprehensive information broad range environmental influences including biological behavioral ability link prenatal child maternal health outcomes needed research program genes environment health pregnancy cohort northern california established create resource conducting research better understand factors influencing womens childrens health recruitment integrated routine clinical prenatal care integrated health care delivery system detail study design data collection methodologies establishing cohort also describe baseline characteristics cohorts underlying pregnant population methods recruitment ongoing october pregnancy cohort included pregnancies racial ethnic minorities pregnancy cohort participants blood samples obtained first trimester mean gestational age weeks second trimester mean gestational age weeks stored future use women invited complete questionnaire health history lifestyle information womens clinical health assessments pregnancy women childrens health outcomes available health systems electronic health records also allows long term follow discussion large diverse cohort pregnancies prenatal clinical data valuable resource future studies utero environmental exposures maternal child perinatal long term health outcomes baseline characteristics pregnancy cohort demonstrate highly representative underlying population living broader community northern california
paper mathematical model describing blood flow porous channel solved numerically blood flow considered fluid flow governing system nonlinear partial differential equations reduced nonlinear system ordinary boundary value problem using suitable similar transformations efficient numerical technique based integration radial basis function process coupled method performed approximate solution boundary value problem numerical results presented figures tables demonstrate efficiency accuracy convergence method moreover effects various embedded model parameters expansion ratio slip coefficient others flow velocity profiles explained graphically
paper introduce technique design cross coupled dispersive delay structures arbitrary prescribed group delay controlled magnitude technique magnitude phase cross coupled separately controlled design example provided illustrate method response synthesized coupling matrix proves validity design method
high prevalence chronic pain individuals infected predictive protective factors development still unclear objectiveto identify factors associated chronic pain individuals methodsthis cross sectional study conducted reference center treatment patients infected brazil study included individuals infected years excluded difficulty respond pain protocol data sociodemographic health behavior clinical characteristics collected standardized way prevalence ratio pain described factors independently associated presence pain assessed multiple logistic regression resultsa total individuals included study mostly female aged years married less eight years education steady income multivariate analysis showed symptomatic sensory manifestations erectile dysfunction overactive bladder self medication physiotherapy depression associated increased likelihood presenting pain hand physical activity religious practice associated decreased likelihood pain conclusion use self medication physiotherapy presence depression independently associated neurological symptoms infected patients religious practice physical activity protective development pain published elsevier open access article license
auditory approach proposes concept mediation key process teaching literacy consisting identifying units text access strategy reading comprehension multimodal structuring proved several works communication recently shows key aspect oral code taking account conceptual framework provide new didactic clues related strategies early reading considering relationship auditory approach reading multimodal discourse
previous research stress memory interactions suggested stress increases production false memories however accumulating work shown effects stress learning memory depend critically timing stressor hypothesized brief stress administered immediately learning reduce rather increase false memory production present study participants submerged dominant hand bath ice cold water stress stress min participants completed short term memory task deese roediger mcdermott paradigm presented different lists semantically related words sugar list tested memory presented words non presented unrelated words non presented semantically related critical words sweet stress overall significantly reduced number critical lures recalled false memory participants addition stress enhanced memory presented words true memory female male participants findings reveal stress enhance false memory production timing stressor important variable mediate effects results important implications understanding accounts events observed following stress elsevier inc rights reserved
background current analyses examined whether dysregulation profile used identify children adolescents high risk complex serious psychopathology correlated emotional behavioral problems behavior suicide ideation assessed using child behavior checklist youth self report residential care sample methods children adolescents aged years living residential care switzerland completed professional caregivers completed participants meeting criteria score anxious depressed attention problems aggressive behavior scales compared presence complex psychopathology defined presence emotional behavioral disorders also prevalence several psychiatric diagnoses suicidal ideation traumatic experiences behaviors problems related quality life results diagnostic criteria met just participants eight participants met criteria instruments analyses conducted separately groups associated complex psychopathology cases according cases according somewhat likely associated psychiatric disorders associated problems limitations relatively small overlap analyses conducted largely different samples likely contributing different results conclusions despite high rate psychopathology population studied able detect small proportion complex psychiatric disorders result questions validity detecting subjects complex serious psychopathology possible different screening instruments effective elsevier rights reserved
background objective medical research council score simple objective scale assess main complaint patients chronic interstitial lung disease ild sought investigate whether predictor outcome patients chronic ild methods one hundred fifteen patients idiopathic pulmonary fibrosis ipf non ipf ild retrospectively studied baseline time diagnosis month changes considered endpoints month clinical progression defined either absolute reduction forced vital capacity fvc percent predicted decline min walk distance hospitalization respiratory causes lung transplantation assessment death month survival results end observation period subjects experienced clinical progression including deaths patients ipf longitudinal increase predicted clinical progression significantly area curve auc sensitivity specificity baseline strong predictor mortality auc sensitivity specificity patients non ipf ild longitudinal increases baseline values predictive clinical progression auc sensitivity specificity mortality auc sensitivity specificity considering whole population increase fvc decline independent predictors mortality conclusion longitudinal increases predict poor outcome chronic ild good accuracy baseline remains strong predictor mortality ipf included global assessment clinical course chronic ild
aim study determine ascorbic acid content antioxidant activity base apple addition frozen dried leaves upon enrichment frozen dried naturally apple characterized increase phenolic compounds times accordingly antioxidant activity addition ranged obtained characterized content ascorbic acid content results sensory evaluation colour taste consistency apple addition differ significantly prior whereas evaluated factors decreased significantly elsevier ltd rights reserved
context energy use worldwide remaining carbon energy buildings account total energy consumption appropriate buildings contribute reduce consumption contribute increase renewable energy production become key node energy grid related energy transport eco city moreover smart buildings near future huge amount data numerous sensors connected city territory big data analytics cloud computing bring new services presenting paper smart building green new building centre eco city france designed many green ideas living lab supporting research teaching field sustainability paper focusing energy field deals electrical micro grid interaction
parametric convex programming received lot attention since many applications chemical engineering control engineering signal processing etc inverse optimality plays important role many contexts image processing motion planning paper introduces constructive solution inverse optimality problem class continuous piecewise affine functions main idea based convex lifting concept accordingly algorithm construct convex given partition put forward following idea important result presented article continuous piecewise affine function defined partition solution parametric linear quadratic programming problem regarding linear optimal control shown continuous piecewise affine control law obtained via linear optimal control problem control horizon equal prediction steps
background linked drug control systems considered contribute access controlled medicines leaving millions people pain suffering studies focus access opioids treatment severe cancer pain study aims identify specific access barriers patients opioid dependence legislation regulations central eastern european countries methodsthis study builds previous analysis legislation regulations part framework access opioid medication europe project depth analysis undertaken determine specific barriers patients opioid dependence need opioid opioid agonist therapy country number nature specific potential barriers patients assessed according eight categories prescribing manufacturing usage trade distribution additional keyword search conducted minimize barriers barriers additional category language recorded qualitatively countries included greece turkey countries except showed specific potential barriers legislation regulations total number barriers varied two number categories varied one five specific potential barriers shown categories prescribing usage total number single category varied one prescribing individual differences countries specific potential barrier shown example variation minimum age criteria admission ranging special cases greece countries language legislation opioid dependence likely experience specific barriers accessing opioids addition experienced non dependent patients
previous research documented sex differences nonverbal communication remained unknown whether similar sex differences exist regard olfactory communication via relatively neglected nonverbal communication medium women generally better sense greater sensitivity emotional signals hypothesized compared male participants relative neutral control condition female participants state producing facial used double blind experiment measure receiver partial reproduction state controlling moderating influence sex receiver results indicated female participants state present study revealed boundary condition effective reporting behavioral evidence sexual asymmetry olfactory communication via
objective investigated ability bone marrow derived mesenchymal stem cells overexpressing microrna mir repair cardiac damage induced rats methods sprague dawley rats similar weeks old selected isolate culture harboring mir generated transfected rat rats assigned untreated negative control group groups injected alone followed mir proliferation migration cells detected transwell mir expression mrna expressions cell lymphoma bax bcl associated protein vascular endothelial growth factor vegf tested qrt pcr western blotting applied detect protein expressions bcl bax vegf results using transwell assays found overexpressed mir exhibited greater proliferation migration ultrasonic immunohistochemical analysis demonstrated among five groups group exhibited improved heart function enhanced angiogenesis moreover mir group showed enhanced expression bcl vegf reduced expression bax conclusion findings suggest mir overexpression enhanced proliferation differentiation expression key factors bcl vegf bax essential cardiac damage induced restoring heart function
introduction external beam radiation therapy patients left breast cancer site cause myocardial perfusion abnormalities intended study change abnormalities short long term post radiotherapy follow methods twenty patients left patients right breast cancer comprised exposed control groups respectively patients low risk coronary disease underwent myocardial perfusion scans years external beam radiation therapy bed modified radical subjects recruited two bigger cohorts previously reported data scans months scans acquired injections mci peak pharmacologic stress rest change perfusion abnormalities visual assessment baseline years follow time compared exposed control patients results exposed patients visual perfusion abnormality scores compared control subjects indices perfusion abnormality normalized control subjects baseline follow scans difference score stress score difference perfusion abnormalities exposed subjects remained unchanged along years follow conclusion radiation induced myocardial perfusion abnormalities patients left breast cancer cause permanent coronary disease time
neural network field many application models proposed previous analog neural network models composed operational amplifier fixed resistance difficult change connecting weight network study used analog electronic multiple sample hold circuits connecting weights describe input voltage easy change connection coefficient model works analog electronic circuits finish learning process short time model enable flexible learning however structure model one input one output network improved number unit network layer moreover suggest possibility realization hardware implementation deep learning model
hereditary angioedema hae rare serious potentially life threatening autosomal dominant condition caused low dysfunctional esterase inhibitor inh uncontrolled contact pathway activation symptoms characterized spontaneous recurrent attacks subcutaneous typically involving face extremities bowel prevalence hae estimated without known racial differences causes psychological stress significant socioeconomic burden early treatment prevention attacks associated better patient outcome lower socioeconomic burden new treatments better evidence base management emerging together move hospital centered patient centered care enable individualized tailored treatment approaches
glutamate principal excitatory neurotransmitter central nervous system actions related behavioral effects drugs last two decades basic neuroscience research preclinical studies animal models suggesting critical role glutamate transmission drug reward reinforcement relapse although interest centered post synaptic glutamate receptors synthesis glutamate brain also contribute imbalances glutamate homeostasis key feature glutamatergic hypothesis addiction main glutamate producing enzymes brain dysregulation function associated neurodegenerative diseases neurological disorders however possible implication enzymes drug addiction remains largely unknown mini review focuses brain alterations vivo exposure drugs abuse discussed context glutamate homeostasis theory addiction recent findings mouse models shown drugs induce changes expression profiles key glutamatergic transmission genes although molecular mechanisms regulate drug induced neuronal sensitization behavioral plasticity clear
watershed wetland covering nearly southeastern united states florida degraded human dominated environment unique important ecosystem provide variety important environmental services society nature past century half anthropogenic actions severely impacted disrupting natural water flow causing water pollution result native flora important habitats lost invasive species become prevalent water contaminant concentrations increased accelerating efforts made towards preserving ecosystem restoring water flow improving water quality explore complex important aquatic ecosystem critically review relevant environmental history major terrestrial aquatic characteristics dynamics engineered changes water flow major sources impacts nutrient pollution trends system response pollution mitigation actions recent regulatory efforts driving restoration
recent developments domains ambient intelligence ami internet things cyber physical systems ubiquitous pervasive computing etc led numerous attempts apply ict solutions occupational safety health area literature review reveals wide range examples smart materials smart personal protective equipment ami applications developed improve workers safety health use solutions modifies work methods increases complexity production processes introduces high thus created smart working environments new conceptual framework dynamic management called proposed framework based new paradigm risk management consisting real time risk assessment capacity monitor risk level worker individually rationale context based reasoning respective model dedicated also proposed
although osteoarthritis traditionally regarded non inflammatory disease reports increasingly suggest inflammatory least certain patients patients often exhibit inflammatory infiltration synovial membranes macrophages cells mast cells cells plasma cells natural killer cells dendritic cells etc although previous reviews summarized knowledge inflammation pathogenesis far know report review current understanding cells especially cell subtype biology review highlights current understanding role cells pathogenesis attention cells cells cells cells cells regulatory cells follicular helper cells cytotoxic cells memory cells even cells gamma delta cells cluster differentiation restricted cells findings highlight importance cells development progression suggest new therapeutic approaches patients based manipulation cell responses
objectives measure early due self reported rheumatic diseases estimate respective indirect costs years working life lost methods used individual level data national cross sectional population based study september december inhabitants randomly surveyed order capture characterize cases within representative sample portuguese population analysis used participants aged years near official age national database used calculate productivity values gender age region using human capital approach estimated difference participants current age respective age potential years working life lost given difference official actual ages also calculated percentage time inactivity inactivity ratio active age range years old results portuguese population ages years self reporting due estimated annual indirect cost following premature attributed sic million sic per capita sic per self reported patient sic per early due females contributed costs sic million sic per capita sic males observed total number accumulated per inhabitants per inhabitants mean inactivity ratios respectively patients higher values disability highest risk early conclusions early attributed self reported amounts approximately national gross domestic product due large public health concern economic impact highlight need prioritize investments health social protection policies targeting patients rheumatic conditions royal society public health published elsevier ltd rights reserved
develop silico model predicting percutaneous absorption disposition kinetics chemicals skin layers facilitate design drug delivery systems skin care products risk assessment occupational consumer exposure general purpose computer model simulating skin absorption disposition kinetics stratum viable developed equations proposed determining partition diffusion properties chemicals considering molecular partition binding mobility skin layers vitro skin penetration data chemicals used validate model observed simulated disposition skin layers compared tested chemicals tested chemicals experimental model results good agreement coefficient determination relative root mean squared error disposition kinetic parameters maximum concentration area curve viable epidermis initially increased reached decreased increase considering skin physiological structure composition partition diffusion properties chemicals skin layers determined allows silico simulation percutaneous absorption disposition kinetics wide chemical space model produced results good agreement experimental data chemicals suggesting much improved framework support delivery drug cosmetic integrated risk assessment
data association hormone replacement therapy increased risk venous thromboembolism postmenopausal women conflicting observed differences oral estrogen oral estrogen combination formulations result bias depletion methodswe used united clinical practice research identify cohort women aged incident cases occurring study period identified using nested case control approach rate ratios current use oral estrogen oral estrogen combinations estimated function duration use using conditional logistic regression cubic resultsthe cohort postmenopausal women included cases matched controls risk increased current use oral estrogen confidence interval oral estrogen confidence interval relative non use assessed duration use risks oral formulations particularly elevated first year use reduced subsequently conclusionthe phenomenon depletion considered cohort studies evaluating acute side effects medications achieved estimating risk function current use also duration use copyright john wiley sons ltd
hiv treatment prevention initiatives promote antiretroviral therapy art access optimal adherence produce viral suppression among people living hiv prevent transmission hiv art treatment common among use drugs undermine effectiveness semi structured interviews conducted use drugs experienced treatment art setting community wide initiative canada examine influences outcomes study participants attributed art treatment fatigue analysis revealed individual social structural influences events including prior adverse art related experiences among long term treatment histories experiences social isolation continuity hiv care following disruptive events findings treatment fatigue focusing attention underlying mechanisms demonstrating need comprehensive structural reforms targeted interventions optimize among drug using
background controversy ongoing interest measurement functionality personal social level objectives validate version world health organization disability assessment schedule determine added value physical psychological health subscales short form methods cross sectional design data collected december march using three questionnaires pss sample people disabilities without disabilities greece internal consistency construct criterion related validity assessed alpha exploratory factor analysis correlations added value multivariable linear regression results satisfactory pss respectively exploratory factor analysis confirmed existence one two factors people without disabilities respectively score showed significant negative correlation physical mental health scale score especially strong physical health positively related pss score multivariate analysis mental health appraisal related perceived stress groups conclusions study support validity version warranted use assessment follow people disabilities contributing development suitable policies cover needs providing comparable data surveys using instrument elsevier inc rights reserved
infrastructure systems united states need urgent maintenance preservation networks major component infrastructure systems acceptable level subject stringent yearly maintenance rehabilitation major challenge network owners managers decision makers required develop optimum financial plan minimize total cost maintenance rehabilitation different expected improvements network performance given planning horizon manuscript presents discussion budget planning maintenance rehabilitation scheduling optimization network maintenance rehabilitation expenditure justified net increase asset value cost rehabilitation net worth asset based performance rather book value government standards require owners maintain improve overall condition state infrastructure systems substantial annual investment paper three methods proposed compute long term annual investments networks modified worst first method network optimization approach estimation maximum deterioration rate performance system simulated using methods based simulation results modified worst first method computationally intensive provides optimum budget method using maximum deterioration rate provides lower bound value used absolute lowest value allocated optimization method uses computer programming provides upper bound value small networks anticipated large networks network optimization approach used provide reasonable long term annual three methods modified worst first method provided minimum long term annual budget consistent government requirements american society civil engineers
research investigated relationship false memories induced two different paradigms misinformation deese roediger mcdermott drm misinformation effect refers phenomenon persons witnessed event altered exposure misleading information event drm false memory represents intrusion words semantically related actually presented study session subjects completed misinformation drm false memory tests results showed small significant correlation misinformation drm false memories furthermore using signal detection theory found discrimination ability index related misinformation drm false memories response bias related drm false memory results suggest misinformation drm false memories generally involve different mechanisms shared mechanism involve global discrimination ability
interactions decision variables typically make optimization problem challenging evolutionary algorithm solve exploratory landscape analysis techniques used quantify level variable interactions optimization problem however many studies using techniques investigate interactions limited combinatorial problems studies focused continuous variables paper propose novel measure quantify level variable interactions continuous optimization problems evaluated efficacy measure using suite benchmark problems consisting multidimensional continuous optimization functions differing levels variable interactions significantly results reveal measure robust accurately identify variable interactions show solution quality found correlated level variable interaction given problem finally present results simulation experiments illustrating measure embedded algorithm design framework enhanced algorithm achieves equal better results benchmark functions
analyze role type childrens death resulting severe pneumonia conventional pcr southern blotting situ pcr evaluated detection paraffin embedded lung tissue autopsy samples children fatal outcome pneumonia china period results indicate cause fatal pneumonia samples
key question concerns extent sexual differentiation human behavior influenced sex hormones present sensitive periods development organizational effects occurs mammalian species important sensitive period considered prenatal increasing attention puberty another organizational period possibility decreasing sensitivity sex hormones across transition paper review evidence sex hormones present prenatal periods produce permanent changes behavior good evidence exposure high levels androgens prenatal development results activity occupational interests sexual orientation spatial abilities prenatal androgens smaller effect gender identity insufficient information androgen effects sex linked behavior problems little good evidence regarding long lasting behavioral effects hormones suggestion influence gender identity perhaps sex linked forms psychopathology many opportunities study issue elsevier inc rights reserved
cytotoxic lymphocytes execute killing insulin producing beta cells onset type diabetes mellitus research community come far major events development disease still trigger high resolved information immunological events leading beta cell loss missing past decades imaging immune responses led significant scientific diverse models disease including dynamic imaging immune cells pancreatic onset made possible development advanced animal models allow long term immobilization pancreas use modalities revealed milling microenvironment pancreatic disease onset plethora active players clues answering remaining questions disease lie imaging including key immune cells traffic pancreas cells interact target tissue review highlights discusses recent studies models techniques focused understand immune responses onset imaging
aspergillus lateral flow device recently introduced practical tool diagnosis invasive investigated performance aspergillus point care test diagnosis serum samples collected twice weekly patients received intensive chemotherapy acute leukemia allogeneic stem cell transplantation aspergillus antigen beta aspergillus tests carried according manufacturers recommendations testing repeated modified procedure proven increase sensitivity aspergillus performed without applying pretreatment procedure allow kit fit point care test fungal infections categorized according european organization research treatment cancer invasive fungal infections cooperative group national institute allergy infectious diseases study group criteria total neutropenia episodes patients prospectively followed february january probable diagnosed patients probable pulmonary fungal disease diagnosed one patient diagnosed one patient detected two patients aspergillus positive serum patient probable bronchoalveolar lavage fluid patient probable aspergillus false positive serum two patients although radiological finding documented fever resolved empirical therapy one patients sensitivity aspergillus point care test without pretreatment serum sample low
development genetically modified plants important verify various factors potentially affect risk assessment establish experimental program produce scientific reliable data however time cost consuming process develop plants prepare scientific data governments approval therefore using transgenic hot tolerant new attempted suggest methodological procedures probe saturation southern blot analysis pcr elisa expression analysis identification stability evaluation inserted gene genetically modified plant required approval ten partially overlapped probes covering full length inserted gene produced identify inserted gene stacked single copy partial element existed also identify stability inserted gene stacked hot using probe saturation expression analysis pcr elisa also provide stable expression transcript proteins leaves placenta fruits resistant hot
calcium bioavailability two types enriched calcium citrate calcium nano sized particle distribution studied among female dawley rats milk powder enriched essential nutrients dha epa vitamins calcium bioavailability according recommended dietary west european north american ovariectomized ovariectomized osteoporosis rats used menopause menopause osteoporosis model respectively although nano sized enriched milk greatest calcium bioavailability among groups bioavailability nano sized calcium enriched milk significantly better nano sized calcium citrate enriched milk moreover trends similar bone calcium strength morphology therefore based current results calcium nano sized enriched milk effective enriched milk powder ovariectomized osteoporosis ovariectomized rats model menopause osteoporosis menopause women elsevier ltd rights reserved
investigation strain rate effects mechanical response characteristics thin free standing films crucial design fabrication reliable mems devices also high interest scientific materials engineering views paper present novel apparatus procedure tensile testing thin free standing films wide range strain rates high almost comparable obtained bar tests provide capability unique displacement measurement method applied micro device meets several strict requirements implemented describe recent results experiments performed pure aluminum free standing thin films high rate experiment demonstrates setup capabilities also presented micro device measured properties compared finite element analysis results
background ever increasing knowledge areas cell biology immune system mechanisms cancer allowing new phase immunotherapy develop aim cancer vaccination activate host immune system success observed particularly use vaccine bladder cancer virus proven virus vitro vivo tumour cell lines found susceptible infection currently phase iii clinical trials shown induce immune responses tumours low toxicities methods study examined two main approaches vivo mice using melanoma lung carcinoma llc models initially mice treated immune responses determined cytokine analysis mice also using cell based vaccine subsequently exposed dose cells llc using cell based vaccine established tumours treated subsequent immune responses virus retrieval investigated results upregulation several cytokines observed following treatment replication competent virus also retrieved treated tumours varying levels cytokine upregulation observed replication competent virus retrieved vaccine treated mice prolongation survival delayed tumour growth observed models immune response either using alone cell based vaccine also observed mice conclusion study provides evidence immune response tumours using cell based vaccine tumour models investigated llc cytokine induction observed prolongation survival almost cases suggest new method using clinic
according tree structure description system equations establish dynamic equations system proposed forms equations general simple moreover equations minimum dimension also convenient computer calculating system taken modelling object includes plate dynamic equations three parts established respectively dynamic kinematics equations whole system established influences drag coefficient velocity scan parameters simulated computer programming simulation results accordance flight principle theory verifies modelling method established dynamic equations
previous research found evidence academic benefits longer school years paper investigates one many potential costs increased school year length documenting dramatic decrease youth suicide months school session detailed analysis find potential explanations economic conditions weather seasonal affective disorder patterns explain decrease evidence suggests youth face increased stress decreased mental health school session elsevier ltd rights reserved
twin box popular choice among long span bridge engineers aerodynamic performance system critical stability bridge wind excitation two groups twin box six representative slot width ratios varying utilised investigate influence different wind shapes aerodynamic instability performance torsional divergence flutter two wind shapes various slot ratios investigated wind tunnel tests theoretical analyses based experimental results static wind loads critical flutter wind velocities symmetry wind showed influence development pattern drag force coefficients flutter performance significantly affected slot width ratio also shown effect structural stiffness variation caused change slot width ratio neglected stationary torsional divergence analysis flutter performance twin box asymmetric wind sensitive slot width ratio due existence optimal slot width opposite case symmetric wind especially ratio different aerodynamic damping parts contributing torsional aerodynamic damping participation level degree freedom dof analysed two dimensional three degree freedom method results indicate improvement flutter performance mainly attributed decrease aerodynamic negative damping part caused couple effect torsional vertical motion increase participation level motion flutter onset particle image velocimetry techniques employed reveal change central slot width ratio symmetry wind great influence characteristics especially central slot region slot ratio determined observing flow structures around deck sections terms wind velocity field vortex characteristics elsevier ltd rights reserved
background objective medical image processing contribute detection diagnosis human body anomalies represents important tool assist minimizing degree uncertainty diagnosis providing specialists additional source diagnostic information anomaly affects approximately population modifies vision eyes properly align influencing vision depth perception additionally results aesthetic problems reversed age however use low cost computational resources assist diagnosis treatment yet widely available work presents computational methodology automatically diagnose digital videos featuring cover test using computer process videos methods method proposed validated patients consists eight steps acquisition detection region surrounding eyes identification location identification location eye movement tracking detection identification evidence presence diagnosis results detect presence proposed method achieved specificity value sensitivity value accuracy diagnosis patients procedure recognized diagnose accuracy value measures lower average error deviation measure delta conclusions demonstrated feasibility using computational resources based image processing techniques achieve success diagnosing using cover test despite promising results proposed method validated greater volume video including types elsevier rights reserved
soft drink industries suffer inadequate handling product losses generally considered wastes products contribute wastewater organic load augmentation cause environmental impact study industrial scale process based multistage fermentation proposed treat reuse soft drink high loaded effluents valuable components production upstream segregation non consumed performed reduce organic load soft drink wastewater characterization revealed important sugar content organic compound undoubtedly responsible high organic load soft drink wastewater thus sugar content soft drink waste single cell proteins proposed solution reduce wastewater load soft drink wastewater including rejected returned products tested used substrate yeast biomass production using commercial yeast strain saccharomyces cerevisiae effect nutrient supplementation initial sugar concentration effect culture media biomass production investigated using batch fed batch process results indicated supplementation necessary successful fermentation gave better sugar biomass conversion yields depletion sugar contained soft exceeded media fed batch culture revealed biomass concentration improvement reaching compared batch biomass concentration resulting batch cultures proposed process shown enable industries reduce water pollution generation site segregation procedure storage system product losses source medium single cell protein production
opportunity engage scientific research important often neglected component undergraduate training biology describe curriculum innovative course based undergraduate research experience cure appropriate large introductory cell molecular biology laboratory class leverages students high level interest cancer course highly collaborative emphasizes analysis interpretation original scientific data course students work teams characterize collection mutations human tumor suppressor gene via expression analysis yeast initially student pairs use qualitative quantitative assays assess ability mutant activate expression reporter genes localize mutation within structure facilitated discussion students suggest possible molecular explanations defects displayed mutants propose experiments test hypotheses execute second part course use western blot determine whether mutant levels reduced dna binding assay test whether recognition three target sequences compromised fluorescence microscopy assay nuclear localization students studying mutant periodically discuss interpret combined data course session students present findings peers instructors greater community based experience provide recommendations development similar large introductory lab courses authors biochemistry molecular biology education published wiley periodicals inc behalf international union biochemistry molecular biology
ambient assisted living systems based sensor technologies seen key ageing society however approaches space provide truly generic ambient space one capable assisting people diverse medical conditions also habits healthy developing medical conditions recognition activities daily living key understanding appropriate efficient care however recognition particularly difficult achieve multi resident spaces especially single mode albeit carefully solutions limited capabilities address limitations propose multi modal system architecture remote healthcare monitoring home gathering information multiple diverse sensor data sources paper report developments made date various technical areas respect critical issues cost power consumption scalability interoperability privacy
public key infrastructure widely used security mechanism securing communications network however known performance issues making unsuitable use networks paper propose secure key management protocol overcome shortcomings scheme repository containing identity corresponding public key vehicle road side unit exchanges lists eliminated furthermore scheme uses symmetric keys derived based matrix based key agreement scheme reduce high computational costs using asymmetric cryptography demonstrate efficiency performance evaluations terms transmission storage overhead network latency key generation time analytical results show scalable outperforms based simulation results indicate key generation time scheme less existing elliptic curve protocols addition use prove scheme secure active attacker model show scheme secure denial service attacks wide range malicious attacks
elliptic curve cryptography ecc branch public key cryptography widely accepted secure data exchange many resource limited devices paper presents novel hardware cryptographic processor ecc general prime field optimized circuit level introducing new parallel modular multiplication algorithm efficient hardware architecture offers significant improvement previously used techniques subsequently system level optimized exploiting available high degree parallelism using coordinates incorporating four parallel multiplier units proposed hardware implemented field programmable gate arrays bit scalar multiplication completed cycle count field programmable gate array respectively implementation maximum frequency occupies look tables whereas slices results show proposed design offers significant improvement computation time significant reduction cycle count compared reported designs therefore good choice used many ecc based schemes copyright john wiley sons ltd
accumulation deposition amyloid beta beta brain represent early perhaps necessary step pathogenesis alzheimers disease beta accumulation leads formation beta aggregates directly indirectly lead eventual neurodegeneration beta production accelerated many familial forms early onset increasing evidence indicates impaired clearance beta evident late onset uncover mechanisms underlying impaired beta clearance examined role low density lipoprotein receptor related protein astrocytes although shown play critical roles brain beta metabolism neurons vascular cells role astrocytes abundant cell type brain responsible maintaining neuronal homeostasis remains unclear show plays critical role brain beta clearance knockdown primary astrocytes resulted decreased cellular beta uptake degradation addition silencing astrocytes led downregulation several major beta degrading enzymes including matrix insulin degrading enzyme important conditional knock gene astrocytes background app mice impaired brain beta clearance exacerbated beta accumulation accelerated amyloid plaque deposition without affecting production together results demonstrate plays important role beta metabolism restoring expression function brain effective strategy facilitate beta clearance counter amyloid pathology
internet databases small molecules enzymatic reactions metabolism emerged useful tools food science database searching also introduced part chemistry enzymology courses food technology students resources support search information single compounds facilitate introduction secondary analyses large datasets information retrieved databases searching compound name structure help chemical codes drawn using molecule editing software data mining options enhanced network links cross links databases databases reviewed article belong two classes tools concerning small molecules including general specialized databases food components tools enzymes metabolism problems associated database application also discussed data summarized computer databases used calculation daily intake bioactive compounds prediction metabolism food components biological activity prediction interactions food component drugs
laminar forced convection heat transfer water horizontal studied middle section wall lower temperature compared entrance fluid simulations performed reynolds numbers nanoparticle volume fractions inside two dimensional rectangular length width two dimensional governing equations discretized using finite volume method effects position nanoparticle concentration reynolds number thermal hydraulics behavior flow investigated results terms velocity temperature number profiles isotherm model predictions found good previous studies results indicate normal internal significantly enhance convective heat transfer within however added high cause larger friction factor compared corresponding constant height results also illustrate increasing heights volume fraction nanoparticles friction coefficient heat transfer rate average number tend augment addition simulation results confirm changing solid volume fraction height cause significant changes temperature dimensionless velocity along flow areas elsevier inc rights reserved
background small brown important pest crops acts transmission vector multiple rna viruses rapid diagnosis virus vector crucial efficient forecast control viral disease reverse transcription polymerase chain reaction pcr rapid sensitive reliable method virus detection traditional pcr contains rna isolation step widely used virus detection insect however using traditional pcr detecting rna virus individual becomes challenging expensive reagents procedure associated rna isolation processing large number samples results established simplified pcr method without rna isolation rna virus detection single method achieved single sterile water using crude extract directly template pcr crude extract containing virus rna prepared approximately two minutes rice virus rice black virus virus successfully detected using simplified method detection results validated sequencing dot assay indicating simplified method reliable detecting different viruses insects evaluation sensitivity method showed detected cdna crude extract fold compared traditional pcr rna isolation simplified pcr method greatly reduces sample processing time decreases detection cost improves efficiency avoiding rna isolation conclusions simplified pcr method developed rapid detection rna virus single without rna isolation step offers convenient alternative traditional pcr method
attention deficit hyperactivity disorder neuropsychological developmental disorder characterized pervasive symptoms hyperactivity impulsivity whereas known children still little information adults including prevalence indeed actually epidemiological studies france despite considerable impact disorder patients professional affective life moreover rarely isolated many comorbidities often complicate diagnostic investigation known called composed two main categories symptoms attentional disorder disorder also remains major symptom objective aim study evaluate prevalence impulse control disorders icd also psychological addictive comorbidities among adult patients total patients specialized consultations adult evaluated study included presenting clinical criteria method used dsm impulsive disorders interview semi structured clinical interview assessing impulse control disorders icd compulsive compulsive sexual behaviour intermittent explosive disorder mini international neuropsychiatric interview order evaluate psychiatric addictive comorbidities results patients met early criteria years half patients presented mixed type impulsive forms type vast majority patients showed complete form total symptoms impulsive hyperactivity category presented sub form symptoms least one category regarding found proportion patients least one frequent icd intermittent explosive disorder followed compulsive pathological gambling compulsive sexual behaviour among psychiatric comorbidities evaluated generalized anxiety disorder followed major depressive episode disorder episode social bulimia nervosa antisocial personality disorder obsessive compulsive disorder regarding addictive comorbidities found prevalence substance abuse non alcohol followed alcohol abuse substance dependence non alcohol alcohol dependence conclusion adults continues france aim study evaluate prevalence impulse control disorders psychiatric addictive comorbidities adults results enable quantitative qualitative data french adults disorder rarely remains isolated often associated many others especially anxiety mood disorders also observed impulsivity heart either impulsive behaviours addictive disorders considering lack studies adults difficult compare data diagnosis complex controversial moreover strong prevalence comorbidities points importance differential diagnosis paris
article explores illicit labor two women prison lens gendered unequal distribution care places burden labor women primarily responsible care adult children diagnosed aids women entered cocaine commodity chain order provide children medication administered state healthcare form national health systems makes poor women difficult perform order afford care childrens health entered labor market war drug policies subsequently illicit labor therefore extension removal care children resulted health consequences article based ethnographic largest womens prison
background mobile health apps shown improve health indicators concerns remain inclusion populations low medium income countries new technologies atrial fibrillation chronic condition challenging management previous studies shown socioeconomic differences prescription anticoagulant treatment shared decision strategies encouraged achieve better outcomes aid doctors patients matter objective describe development app aid shared decision doctor patient anticoagulation prophylaxis low income low literacy population brazil basis research suggest processes followed developing apps context methods multidisciplinary team collected information target population needs detected best opportunity insert app current health care literature subject reviewed important data selected delivered good easy terminology friendly design app evaluated setting results steps suggested develop app target characterize problem target user review literature translate information knowledge protect information evaluate usability efficacy conclusions expect recommendations guide development new apps scientific basis
manuscript soliton pulse propagation nonlinear tunneling cubic media investigated effect propagation characteristics soliton pulse analytically investigated using similarity transformation particular investigate propagation dynamics soliton pulse dispersion barrier free soliton investigating obtained soliton solution found strong influence soliton dynamics pulse compression amplification two important dynamics soliton cubic media open new possibilities improve communication system moreover surprisingly observe dispersion formed case whereas barrier formed free case certain applications construction logic gate devices achieve switching
cortical surface area expanded human evolution similar patterns cortical expansion observed childhood development intriguing hypothesis high expanding cortical regions also show strongest correlations intellectual function humans however know regional distribution correlations intellectual function cortical area maps onto expansion development evolution sample participants show regions cortical area correlates visuospatial reasoning abilities generally high expanding development evolution several regions frontal cortex especially anterior cingulate showed high expansion development evolution area regions related intellectual functions humans low expanding areas related cognitive scores findings suggest cortical regions involved higher intellectual functions expanded development evolution radial unit hypothesis provides common framework interpretation findings context evolution prenatal development additional cellular mechanisms dendritic likely impact area expansion later childhood
text proposes time essentially related ones visual metabolic rate metabolic rate regulated speed intake energy rate production adenosine atp visual areas authors working hypothesis visual area brain known human region involved motion detection region responsible time perception time sense thus compiled visual region speed human perception reality time relationship human perception reality rate reality taking place given light waves environment hence vision visual cortex area important aspects answering question time looking clock time governed rate metabolism rate production atp mitochondria example general human metabolism fast time runs slow metabolic rate relatively slow time runs relatively faster many factors enter speed metabolism age sex drug effects velocity compared speed states light mental states sleep relationship time space discussed metabolic rate mind uncertainty principle quantum picture reality adopted model qualitatively space time showing connected space time idea discussed relation paradox suggests space time indeed events entropy defined reality understood terms speed processing time caused long term synaptic neurons within brain space time analyzed compared visual metabolic rate probable consequences model proposed
paper presents study influence geotextile behaviour soft soils improved fully penetrating columns influence analysed means measuring soil column stress distribution pore pressures soil deformation consolidation process purpose horizontal slice representative unit cell analysed means small scale laboratory tests tests carried large instrumented cell results showed vertical stress supported columns times sustained non ones stress concentration factor columns clearly higher obtained tests non columns finally improvement relation presented ratio settlement soils reinforced ordinary columns settlement non treated soft soil settlement reduction factor around soil treated columns soil non columns elsevier ltd rights reserved
background prostate specific antigen psa important prostate cancer biomarker also protease expressed high concentrations normal malignant prostate psa secreted inhibitory removed full activity variants assumed inactive found blood prostate cancer patients indicative poor clinical outcome despite abundance clinical reports understanding enzymology limited part due lack appropriate experimental systems sought develop series psa derived mutants help enhance understanding gene methods sixteen variants generated characterized variety biochemical methods results cdna provided template generating panel included variants abolished removal disabled enzymatic activity facilitated cell based conversion active conformation purified variants proteolytic activity examined using substrate known psa proteins physiologically relevant inhibitors upon demonstrating successful generation purification psa variants characterized activity describing cleavage synthetic biologic substrates serum protease inhibitors finding exploited development self activating mutant psa exhibited greatest enzymatic activity variants conclusions system described herein prove useful varied applications partially functional relatively high activity compared mature enzyme demonstrating intrinsic activity suggest prostate cancer patient serum implications understanding disease wiley periodicals inc
good virtual learning space convey pertinent learning information adequate time locations favor knowledge acquisition considering consolidation internet improvement interaction searching learning mechanisms propose generic architecture called create virtual learning spaces building cultural institution documents precisely proposal automatically create ontology based virtual learning environments thus relevant learning materials virtual propose use ontologies represent key concepts semantic relations user machine format concepts together data extracted real documents stored digital storage format xml datasets relational databases etc displayed ontology based learning space enables use available features tools learn specific domain according approach discussed desired virtual specified rigorously domain specific language designed implemented validate proposed architecture three case studies used instances architecture authors published elsevier
article constitutes critical reflection gender approach main aspects government program overcoming poverty extreme poverty ethical family income review official documents press releases academic research main objective understand analyze representations gender present social program implications women identified main recipient according analysis made possible see women role mediators public policy families led reproduction traditional gender roles women reproductive domestic role subject rights
monolayer endothelial cells blood vessel wall forms barrier regulates tissue fluid homeostasis transport nutrients migration blood cells across barrier number signaling pathways molecules mediate endothelial permeability plays important roles variety physiological pathological conditions fatty acid binding proteins able bind various hydrophobic molecules long chain fatty acids member family plays important role maintenance glucose lipid homeostasis angiogenesis present study found mammalian highly expressed developing brain vessels zebrafish knockout gene caused hemorrhage zebrafish brain mediated gene knockdown hemorrhage mutants furthermore demonstrated permeability brain vessels mutant significantly higher control addition cox inhibition partially rescued brain vessel integrity defects caused loss function suggesting integrity defect relevant fatty acid function
oral immunotherapy offer alternative elimination diets peanut allergy children treatment proposed following oral challenge test agreed entered oral immunotherapy study treatment failures patients underwent second oral challenge treatment cumulative dose clinical severity score compared skin tests assay ige specific peanut allergy first performed prior follow mean age patients years median time two challenge tests years mean cumulative dose peanut peanut increased significantly conversely clinical severity score significantly reduced two challenge tests serious adverse effects reported immunotherapy treatment paediatric population administered patients homes confirms efficacy therapy acceptable benefit risk ratio consistent data oral immunotherapy peanut allergy part therapeutic approach children food allergies elsevier masson sas rights reserved
numerical often faced challenge numerically reproduce physical behavior soil geosynthetic interaction problems using assumed values missing soil interface model parameters paper examines two examples using finite difference method horizontal geosynthetic geogrid reinforcement layer box geosynthetic geotextile reinforced soil layer void also presents results parametric sensitivity analyses missing soil interface model parameter values identifies values give best agreement measured data paper demonstrates correct modeling geometrical nonlinearity key accurately predicting performance geosynthetic reinforced soil systems controlled membrane effect lessons learned study interest numerical numerical model design geosynthetic reinforced soil systems
intensity based algorithms popular algorithms dynamic laser measurement physical biological activity output measurement two dimensional map qualitatively regions higher lower activity paper proposed filtering activity maps enhance visualization enable quantitative determination activity time scales first step proved severe spatial fluctuations within map resemble signal dependent noise second step illustrated implementation proposed idea applying filters non normalized normalized activity estimates derived synthetic experimental data statistical behavior estimates analyzed choose filter parameters substantial probability density functions estimates achieved filtering filtered maps exhibit improved contrast allowed quantitative description activity
juvenile offenders young manage terms independently parents participation process critical youths successful transition crime however parents capacity support childs legal process depend parents knowledge justice system operates present study first quantify mothers knowledge juvenile justice system authors examine association mothers legal knowledge legal participation youth offending using longitudinal sample dyads total mothers sons first time juvenile offenders results indicate mothers averaged test legal knowledge importantly mothers knew least system also participated least sons legal process mothers participated least sons self reported offending within first year arrest practitioners encouraged educate parents juvenile offenders rights responsibilities create meaningful avenues parental involvement set youth success first arrest
brain metastasis non small cell lung cancer remains challenge physicians occurs patients advanced stage adenocarcinoma lung often regarded sign disease progression death likely promising agent even failure patients lymphoma kinase driven non small cell lung cancer brain metastasis resulting durable response intracranial extra cranial diseases
two component signal transduction system common mechanism signal transduction exists almost bacterial species putative two component genes located vicinity red locus modulate antibiotic red biosynthesis study mutants knock knock constructed using homologous recombination double crossover red production two mutants decreased dramatically compared wild type strain however production act two mutants changed significantly results suggested participated regulating antibiotic red synthesis northern blotting analysis indicated regulate biosynthesis red influencing transcription cell growth therefore specific pair likely regulates red gene cluster positively
epstein barr virus ebv affects clinical outcome ebv positive diffuse large cell lymphoma remains largely unknown viral oncogene tumorigenesis cell survival therefore examined association high cells drug resistance first assessed surrogate marker high cells target gene highly expressed cells cells survived longer following treatment combination doxorubicin genes associated interferon alpha allograft rejection kappa also overexpressed cells specifically treatment increased expression levels dose dependent fashion addition exogenous greatly increased levels rendered cells resistant regulating anti apoptotic genes bcl cells sensitive inhibitors inhibition kappa combination decreased levels effectively induced cell death cells suggest high cells responsible poor drug response ebv perturbation kappa stat signaling pathways increases toxicity cells
modern nanotechnology produce metallic non metallic particles nanometer dimensions unique optical mechanical magnetic electrical thermal properties purpose review important published articles enhancement convection heat transfer using nanoparticles dispersed ethylene glycol effects thermal properties applications paper reviews articles relevant nanoparticles suspended studies thermal properties including experimental measurement correlations reported effects volume fraction temperature base fluid included stability shown testing avoid clusters many applications paper applications different types heat cooling systems solar energies reviewed field economics reduces manufacturing costs result using low temperature process order focus future studies applications articles field summarized
applying pesticides crops one causes water pollution surface runoff used respectively crop plants widely explore effects three pesticides aquatic organisms superoxide dismutase sod glutathione transferase activities determined exposure ages several low concentrations respectively main reproductive parameters including first pregnancy time first time number first total exposures concentrations pesticides described also measured results showed activities increased lower concentrations decreased higher concentrations exposure three pesticides respectively activities sod showed changes exposure time prolonged activities decreased activities sod increased exposure first pregnancy time first time delayed number first total per female decreased increasing concentrations results corroborated activity sensitive pesticides sod activity significant relationship total pesticides dose activity exposure total exposure
high speed sliding electrical contact large current temperature contact area rises quickly coupling action friction heating heating electric arc heating rising temperature seriously affects conductivity components yield strength materials affects contact state lead damage shorten service life contact elements therefore vital significance measure temperature accurately investigate temperature effect damage rail surface aiming problem components damage high speed sliding electrical contact transient heat effect contact surface explored influence regularity sliding components damage obtained kind real time temperature measurement method rail surface high speed sliding electrical contact proposed condition current load based principle infrared radiation non contact temperature sensor used measure rail temperature dynamic distribution temperature field obtained simulation analysis connection temperature changes rail surface damage morphology damage volume analyzed established finally method reduce rail damage improve life components changing temperature field discussed
case files county medical office reviewed analyze due physical child abuse children years old fatal cases mostly involved younger subjects intracranial injuries leading cause death death due injuries uncommon eyes involved cases spinal cord involved cases mostly thoracic area cases previous injuries present significant differences pattern injuries age groups subjects showing signs impact head subjects evidence impact showed significant difference internal injuries association multiple injuries highly suggestive child abuse suspected child abuse postmortem examination including neuropathological radiological information always evaluated together reports medical history
boundary scan technology make virtual probing improve overall product provide effective approach automatic testing based bus paper new boundary scan cell insertion algorithm put forward grounded simplified test signal flow graph sfg modeling board algorithm uses measure based controllability observability evaluate every node defined according distance nodes primary last example given verify algorithm conclusion algorithm paper solve placement problem boundary scan cell automatic testing using boundary scan important application value
aim study explore significant predictors associated therapy outcome patients major depressive disorder major depressive disorder inpatients requiring recruited major psychiatric center south taiwan generally performed maximum sessions symptom severity assessed using item hamilton depression rating scale clinical global impression severity every three sessions last generalized estimating equations method used analyze influence potential variables time respectively fourteen patients completing first three sessions excluded remaining patients included analysis patients treatment resistant depression longer duration current depressive episode higher levels pain likely less symptom reduction acute treatment irrespective depressive symptoms rated using improve efficacy earlier application pain control considered acute course clinical predictors related outcome require investigation future studies
background substitution therapy equipment provision reduced blood borne viruses among people drugs continue share equipment acquire psychosocial interventions address risk behaviours reduce transmission among methods pragmatic two randomised controlled open feasibility study attending drug treatment four regions ninety nine randomly allocated receive three session psychosocial group intervention transmission information plus treatment usual tau information plus tau intervention developed evidence based literature qualitative interviews key stakeholder consultations expert opinion recruitment rates retention treatment completion rates health economic data completion measured feasibility results fifty six percent eligible recruited participants attended least one intervention session london north york participants attended sessions compared attending least one session likely homeless injected drugs greater number days median used greater number last month median adverse events reported followed month post intervention feedback forms confirmed intervention acceptable intervention facilitators participants attended follow attendance associated fewer days last month median fewer injections cocaine analysis questionnaires identified several service use questionnaire categories excluded assessment battery full randomised controlled trial conclusions findings interpreted caution due small sample sizes future definitive rct psychosocial intervention feasible complex needs limited engagement intervention flexible delivery methods greater reach
one main issues preventing large scale exploration full potential electrical circuits lies convergence issues numerical errors encountered computer aided integration differential algebraic equation set governing peculiar dynamical behavior nonlinear two terminal electrical components cases complexity equation set prevents analytical derivation state solutions therefore investigation nonlinear dynamics circuits based upon relies software based integration mathematical equations paper highlight solution accuracy issues arise numerical integration equations propose techniques addressing problems properly guidelines represent useful guide engineers interested numerical analysis models
many patients atopic syndrome symptoms related irritable bowel syndrome ibs symptoms caused asthmatic condition rhinitis known patients defined therapeutic strategies handle cases known patients cause symptoms ibs unclear many patients undergo many diagnostic procedures including invasive investigations quality life qol reduced patients suffer lot disorders like depression anxiety occur end food allergies tested patients pay laboratory tests specific antibodies alternatively activation tests food offered online platforms article causes ibs mast cell activation necessarily food allergies discussed mast cell activation lead histamine intolerance similarities asthma ibs similar therapeutic approach feasible
investigate implication problems keys independence atoms relational databases keys independence atoms show finite implication establish finite general implication also sound complete finite general implication keys independence atoms show general implication keys independence atoms keys general independence atoms polynomial time two classes also show construct relations finally establish conditions sufficient certain classes keys independence atoms interact elsevier inc rights reserved
major public health concern severe diseases attributed exposure ever comprehensive understanding gene microrna expression patterns induced missing objective study evaluate toxicity via genome wide transcriptional analysis model fish zebrafish gene ontology analysis revealed impact gene functional categories induced included oxidation reduction process transport response stimulus response chemical stimulus metabolic process pathway signal net analysis showed critical pathway involved response exposure metabolism cytochrome results verification experiments also demonstrated key genes degree higher induced related metabolism cytochrome including differential expression micrornas corresponding human genome revealed regulate let mir mir mir regulate mir mir mir suggested multiple means induced toxicity living organisms suppression adaptive immune responses autophagy metabolism impaired progression cancers hypertension atherosclerosis myocardial infarction elsevier rights reserved
background study assess longer term opioid medication effectiveness tested double blind non clinical trial effective severe opioid use disorder although participants treatment correctly beyond expected chance perceived treatment assignment affect patients response treatment study tested treatment allocation associated treatment outcomes identified predictors data obtained questionnaires clinical records participants asked medication thought receiving open ended reasons multinomial logistic regression used assess predictors treatment inductive thematic analysis used code open ended responses clinical trial registered national institutes health https show findings participants referred prior experiences opioids presence absence specific drug effects reasons differences illicit opioid use retention however better physical mental health scores participants treatment related observed event higher perceived drug related high scores likely compared likely among made negative comments reasons treatment understanding clues participants use treatment allocation relating treatment expectations integrated accurate information treatment providing opportunity patient physician shared decision making opioid maintenance trial registration national institutes health identifier https show
human adults automatically mimic others emotional expressions believed contribute sharing emotions others although behaviour appears fundamental social little known developmental process therefore examined whether infants show automatic facial response others emotional expressions facial activity major four five month old infants measured viewed dynamic clips presenting visual auditory emotions emotion stimuli display facial expression emotionally congruent whereas visual auditory emotion stimuli displayed emotional faces paired neutral face respectively increased activation muscle response major response observed stimulus onset clearly suggests rapid facial contrast visual auditory emotion stimuli activate infants corresponding muscles results revealed automatic facial present early five months age multimodal emotional information present
paper presents digital testing strategy characterizing analog circuit block operational amplifier amp evaluated due wide application electronic circuits systems proposed strategy amp device test configured respond testing pulse associated output digital buffer reduce high cost generating high frequency clock testing procedure divided two modes estimate reference slew rate evaluate practical slew rate moderate difficulty designing digital buffer highly precise delay time testing concept accuracy time hardware also comprehensively investigated describe proposed testing strategy digital compatibility simplicity testing capability high performance amp main advantages proposed testing strategy easily available discrete devices experimentally employed verify functionality proposed testing strategy integrated application test amp embedded second order key low pass filter simulated tool verify testing feasibility effectiveness proposed strategy
adsorption based cooling systems becoming increasingly popular due continuous rise worldwide demand refrigeration air conditioning study aims enhance cooling performance solar powered adsorption using novel multi walled carbon composite adsorbent numerically validated modeling approach employed evaluate coefficient performance specific cooling power two bed adsorption solar energy input flat plate solar collector employed three different configurations single cover double cover single cover transparent insulation material observed composite adsorbent containing results maximum achievable cooling power adsorption proposed composite adsorbent considered successful potential replacement traditionally used silica gel based use next generation high performance solar adsorption elsevier ltd rights reserved
idiopathic pulmonary fibrosis accounts lethal diffuse lung disease described accumulation fibroblasts loss damage lung epithelial cells causing respiratory failure excessive ros level impairs cellular redox level inflammatory cell infiltration abnormal collagen production induce extracellular matrix accumulation nuclear factor erythroid related factor regulates antioxidant associated genes target preventive effect compound tgf beta induced fibrosis lung fibroblast investigated study cells pretreatment tgf stimulation suppressed collagen production tgf beta induced cells attenuating phosphorylation activating level inhibited tgf beta induced formation decreasing ros enhancing related antioxidant enzyme apoptosis potential dietary agent inhibit tgf beta induced fibrosis prevent oxidative stress induced pulmonary fibrosis elsevier ltd rights reserved
communities morphological changes resulting water pollution anthropogenic activities natural events removal vegetation cover urbanization agriculture sewage release accelerate process aquatic environment present study seeks demonstrate occurrence morphological abnormalities relate changes morphology species composition physical chemical parameters water made monthly five stations river compartment reservoir located state brazil july february reservoir intense occupation surrounding areas agriculture urban industrial activities installation net cage fish cultures contribute water quality deterioration samples collected using pump net mesh size concentrated volume measures physical chemical parameters water obtained multi sensor surface water column density morphology made microscopy twenty three species recorded high organism densities family species morphological abnormalities observed highest densities abnormalities observed sampling stations characteristics influences sewage release abnormalities observed classified two types type abnormality considered increase length intestine size intestinal loop whereas type considered occurrence intestine morphological abnormalities described compared ones described literature results observe abnormalities probably resulting continuous process occurring reservoir due anthropogenic activities around reservoir decrease water volume reservoir caused unusual dry weather period region last years
experimental study shows results analysis performance stand alone renewable energy system greenhouse heating winter day systems consist photovoltaic panels connected daylight hours produce hydrogen store pressure tank night thanks fuel cell hydrogen converted electricity order feed ground source heat pump heat tunnel greenhouse procedure estimating hourly solar radiation hydrogen production consumption short term energy storage partly day also given solar energy usability concept capacity energy storage systems thermal energy load govern effective energy management system performance analysis necessary determine actual total efficiency integrated photovoltaic hydrogen renewable energy systems contribution load overall system efficiency obtained starting amount solar energy available daylight hours used thermal energy night elsevier ltd rights reserved
background suicidal behavior reported associated seasonality however study reported suicidality according seasonality patients major depressive disorder study evaluated relationship suicidality biological rhythm patients methods total patients participated evaluated seasonal patterns wake early best first part day feel best alert late hours suicidal clinical variables including symptom severity results patients seasonality showed significantly higher suicidal ideation patients without seasonality compared morning type participants evening type participants showed higher suicidality suicidal ideation positively correlated tendencies personality traits limitations first analyze causal relationship biological rhythm suicidality secondly suicidal ideation cases reflect actual attempt lastly categorize seasonal pattern summer winter type conclusions findings suggest biological rhythm significantly associated suicidal ideation patients mdd elsevier rights reserved
program total cost saved energy allow comparison cost efficiency across utilities states program types identify potential performance improvements comparing program cost total cost saved energy indicate degree programs leverage investment participants based reported total costs savings information utility efficiency programs estimate savings weighted average total cost saved electricity across states per hour comparing favorably energy supply costs retail rates programs targeted residential market averaged per compared per programs lighting programs average total cost per lower savings costs residential market provide estimates common program types find program administrators participants average splitting costs efficiency half consistent standardized complete reporting efficiency programs needed differing definitions quantification costs savings savings pose challenges comparing program results reducing uncertainties increase confidence efficiency resource among planners policymakers
studies shown thoughts prospectively related subjective health complaints short worry intervention decrease complaints worry prevalent costly tested whether intervention offered online reduce complaints general population randomized parallel group trial conducted self selected participants general population research website participants instructed register consecutive days intervention group instructed worry special min period early evening subjective health complaints inventory administered intervention daily worry frequency duration considered primary outcomes hundred sixty one participants completed study contrary expectation registration group differ intervention group worry frequency duration nevertheless different worry parameters moderately related contrast previous studies using pencil versions worry intervention study suggests direct online implementation effective reducing worry overall participants high trait worry levels reported difficulty reducing via internet require elaborate interventions better incorporate advantages delivering interventions online already known subject cognition hypothesis argues cognition worry rumination acts mediator psychosocial stress produce negative health effects prior research indeed shown worry subjective health complaints prospectively related causality studies showing changes worry induce changes health outcomes scarce mainly conducted young samples studies showed reducing worry using worry intervention reduce daily study add trait daily associated online worry intervention ineffective reducing worry paper pencil interventions directly used online interventions
establishing fundamental task many image processing computer vision applications particular finding non linearly deformed image pair induced different modality conditions challenging problem paper describes simple powerful image transform called local area transform modality robust correspondence estimation specifically transforms image intensity domain local area domain invariant nonlinear intensity deformations especially spectral deformations experimental results show images provide consistency deformed images even random intensity deformations reduces mean absolute difference approximately different pixel ratio approximately average compared conventional methods furthermore descriptors shows superiority conventional methods promising result tasks cross spectral modality correspondence matching gains approximately improvement correct detection ratio improvement recognition rate tasks rgb nir cross spectral template matching cross spectral feature matching respectively reduces bad pixel percentage approximately root mean squared errors task cross radiation stereo matching also improves cross modal dense flow estimation task terms error providing error reduction
cells continuously threatened damage caused reactive oxygen nitrogen species ros produced physiological oxygen metabolism review summarize latest reports role oxidative stress oxidative stress induced signaling pathways etiology colorectal cancer differences ros generation influence levels oxidized proteins lipids dna damage thus contributing higher susceptibility colon reactive species various types formed powerful agents capable damaging dna biomolecules increased formation promote development malignancy normal rates generation account increased risk cancer development aged review focus role oxidative stress etiology cancer discuss free radicals free radical stimulated pathways colorectal carcinogenesis
visual techniques qualitative assessment roads rank roads either good widely used international transport although quantitative techniques international index roughness use techniques involves higher cost technique compared visual one due fact need special quite expensive equipment work developed new quantitative indicator roads able evaluate compare terms surface quality without relying visual analysis low cost acquisition system based analog axis accelerometer microcontroller developed also developed algorithm able evaluate rank road scale ranging two roads visually rated good bad used references tested different types roads without holes tests conducted vehicle running results showed greater amount holes worst quality indicator depends speed vehicle concluded quantitative analysis road automatically done using low cost measuring system
objectives study examined relation team self frequency male athletes internalization body social pressures weight body body satisfaction dietary intent negative affect drive symptomatology design methods used cross sectional survey design collected data electronically male athletes results athletes self times per week reported pressure lose weight lean muscular engaged muscle building behaviors frequently often highest level symptomatology athletes teams conducted mandatory engaged behaviors dietary restriction conclusion particularly conducted contribute appearance body size shape weight turn lead variety behaviors related eating body change elsevier ltd rights reserved
objective objective examine naturalistic usage systems assess use characteristics patterns background systems continue evolve terms capabilities information availability raising concerns distraction potential assessing potential distraction requires understanding challenging different tasks frequently occur driving method high end system use observed across participants period approximately weeks one two different systems provided participants audio video driving performance data collected observed trained two systems integrated satellite radio one case navigation functionalities systems differed vehicle integration advanced features offered results median participant interacted systems every percentile interactions interactions involved adjusting volume although interactions median duration percentile required measurable visual involvement compared matched baseline median total eyes road time across interactions percentile differed significantly across type system interaction longer interactions tended occur vehicle stationary conclusion drivers interact systems driving includes advanced functions self regulation observed application data provide comparison basis use examining driver interactions future systems
success rituximab treatment active suggests cells play critical role inflammation cell activating factor homolog proliferation inducing ligand april critical cell survival however contribution april remains unclear sought determine role april found markedly upregulated april additionally cultured orbital fibroblasts expressing induced produce large amount contrast weak april expression detected exhibited slight response stimulation notably pretreated promoted cell survival effect significantly inhibited neutralizing antibody study indicates express mediate survival cells via mechanism elsevier rights reserved
classic way building software today consists connecting piece code calling method piece code implementing method consider piece code software systems calling non deterministic way providing complex sets services different domains software engineering specially code tools requires powerful integration mechanisms systems developed different developers modified integrating autonomous tools generate various conflicts deal conflicts current integration mechanisms defines specific set rules resolve conflicts integration indeed still big chance changes made developers update changes order make compliant developers updates done others approach presented claims three contributions field software integration first approach eliminate need conflicts resolving mechanism secondly provides mechanism work presence conflicts without resolving finally contribution integration mechanism affect either system evolves introducing intermediate virtual layer two systems introduce delta models consist three parts viability share required elements conflicting elements concepts systems
background total shoulder arthroplasty end stage arthritis severe bone loss poses unique challenge shoulder surgeons current surgical solutions limited associated high complication rates hypothesized custom made computer aided design manufacturing cad cam total shoulder replacement implants worldwide resembling total hip prosthesis offer reliable alternative challenging subset patients methods thirty seven patients deficient end stage arthritis severe bone loss assessed amenable treatment standard anatomic reverse total shoulder implants treated cad cam clinical data collected prospectively analyzed mean follow years results postoperatively pain level activity decreased shoulder score improved points points subjective shoulder value scale improved active forward elevation improved degrees degrees degrees degrees external rotation improved degrees degrees degrees degrees component revision required patients stem fracture prosthesis dislocation conclusion cad cam offers reliable alternative treatment end stage arthritis severe deficiency amenable standard anatomic reverse total shoulder implants maintenance significant pain relief clinical functional improvement year postoperative follow journal shoulder surgery board rights reserved
simple low power low area metal oxide semiconductor field effect transistor fully differential bit analog digital converter stage proposed designed taiwan semiconductor manufacturing company technology using parameters supply voltage inexpensive digital complementary metal oxide semiconductor cmos technology based charge pump technique achieve desired voltage gain independent capacitor mismatch avoiding need power operational amplifier based architecture reduce power area cost various implemented metal oxide semiconductor capacitors offering compatibility cheaper digital cmos process order reduce much required manufacturing cost
background autism spectrum disorder asd neurodevelopmental disease characterized difficulties social communication restricted repetitive behavior interests specific abnormalities language perception precise etiology asd still unknown probably heterogeneous subgroup patients toxic environmental exposure lead imbalance oxidative stress anti oxidant systems previous serum postmortem studies measuring levels glutathione gsh main cellular free radical brain supported hypothesis compound play role pathophysiology autism methods using method single voxel proton magnetic resonance spectroscopy analyzed gsh signal dorsal anterior cingulate cortex dorsolateral prefrontal cortex asd patients normal average matched control subjects hypothesized find decreased gsh concentrations regions results find overall group differences including gsh neither dorsal acc lambda test found trend decreased gsh signals asd patients conclusions unable confirm working hypothesis regarding decreased gsh concentrations asd group studies combining serum cerebrospinal fluid measurements gsh metabolism including regions interest even whole brain spectroscopy needed
surface roughness important factor influencing quality cooking study describe novel rapid low cost method based principal object surface light measure surface roughness using images acquired common digital camera method helps determine surface roughness using gray level frequency distributions transmission images facilitates measurement surface geometry accuracy traditional high performance laser scanning microscopy techniques furthermore method enables rapid measurement entire surface geometry including regions difficult measure conventional laser method owing lower reflectance laser beam
explore first time advanced multiscale mathematical modeling approach support design successful tissue engineering concept mandibular bone latter employs double porous potentially single sized granules packed overall type scaffold material gradually partially replaced newly grown bone tissue process newly developing scaffold bone compound needs attain stiffness mandibular bone normal physiological conditions context question arises compound stiffness driven key design parameters tissue engineering system crack density scaffold resorption bone formation rates tackle question combining latest state art mathematical modeling techniques field multiscale unprecedented suite highly efficient semi analytically defined computation steps resolving several levels hierarchical organization nanometer scale includes several types schemes namely porous solid elements matrix inclusion composites assemblies coated spherical compounds together experimentally known crystals mandibular bone tissue new mathematical model suggests early stiffness recovery within several weeks requires total avoidance scaffolds mid term stiffness recovery within several months additionally promoted provision small sizes combination high bone formation low scaffold resorption rates
digital earth global reference model integrating processing visualizing datasets reference model various data types including digital elevation models imagery universally available entire globe however content detailed features man made structures water bodies vegetation commonly available digital earth paper present interactive system rapid creation integration types content augment digital earth inputs system include available data sources imagery information depicting landscapes urban environments proposed system employs based image assisted tools support interactive creation content adding terrain features visible also basin water bodies use multiscale least square surface fitting generate adaptive triangular modeling forests vegetation use image based techniques take advantage visible regions colors forests man made structures starting single provide simple image assisted tool extract objects correct perspective distortion place desired locations
background foot posture associated many clinical biomechanical outcomes unique medial compartment knee osteoarthritis though treatment including lateral commonly studied patient population effects specific subgroup people medial knee concomitant unknown purpose study evaluate whether lateral custom arch support beneficial lateral alone knee foot symptoms people medial knee osteoarthritis methods twenty six people symptomatic medial knee participated randomized crossover study comparing five degree lateral foot without custom foot arch support intervention two months separated two month period wear main outcomes included western ontario universities osteoarthritis index pain physical function subscales revised short form foot function index pain stiffness subscales timed test regression modeling conducted examine treatment period interaction effects results twenty two participants completed study interaction effects observed outcome significant treatment effects observed timed greater improvements seen lateral arch support within condition significant improvements observed pain physical function pain stiffness lateral arch support use adverse effects reported lateral alone people preferred lateral arch support overall conclusions addition custom arch support standard lateral improve foot knee symptoms people knee concomitant preliminary findings suggest research evaluating role treatment specific sub group people knee warranted
addition two electrons two bond catalyzed light dependent enzyme relying nadph electron donor light independent enzyme bearing asp cluster reduced cytoplasmic electron donors atp dependent manner functions electron donor precise sequence events occurring bond however determined experimentally dark operating enzyme paper present computational investigation reaction mechanism enzyme level theory reaction mechanism begins single electron reduction substrate yielding negatively charged intermediate depending rate cluster reduction reaction either proceeds double single electron reduced substrate alternating proton electron transfer computed reaction barriers suggest cluster reduction rate limiting stage process poisson boltzmann computations full enzyme substrate complex followed monte carlo simulations redox revealed hitherto dependence reaction potential cluster furthermore computed distributions states asp residues used single point computations obtain first time influence states enzyme reaction catalyzes despite ease reduction substrate computations confirmed broad features reaction mechanism obtained medium sized models afforded valuable insights influence amino acids reaction step additional comparisons energetic features reaction intermediates common biochemical redox intermediates suggest surprisingly simple explanation mechanistic differences dark catalyzed light dependent enzyme reaction mechanisms
million people attempt suicide every year worldwide suicide attempts represent major economic burden suicide suffer high rates comorbidity comorbidity rule suicide comorbidity treatment prognosis causes course present narrative review included patterns comorbidity intra axis disorders intra axis disorders axis axis disorders psychiatric physical illnesses also briefly reviewed patterns comorbidity suicide concluded comorbidity different levels appears rule suicide particularly attempt however several issues deserve research regarding patterns comorbidity suicide
work novel electronic lock encode optical signals modulated using code developed build smart home security system based internet things iot five topics interest research optical code optical code ambient light sensor circuit fuzzy controller cloud monitoring system take advantage light emitting components readily available hand held mobile devices smart phones microcontroller transferring even without personal computer real time information lock cloud service platform helps users ensure home safety remote monitoring system using ambient light sensor fuzzy controller novel optical code based electronic lock experimental results show reliability system much improved means highly resistant different illumination conditions work environment therefore functions including coding emitting receiving decoding cloud monitoring work furthermore besides convenience cost reduction incorporating traditional keys smart phones consumer electronics proposed system suitable users ages user friendly operation interface
important ecosystems known kidney earth particularly urban play important role providing natural social beneficial services however urban suffering various human impacts excessive land use conversion air water pollution especially developing countries undergoing rapid urbanization therefore great necessity derive timely biomass information optimal design management protection urban paper develop set models estimating ground biomass national wetland park china using optical images synthetic aperture radar sar images series vegetation indices vis derived optical data introduced along spectral data modeling methods consist curve estimation linear regression multivariable model back propagation neural network modeling curve estimation combination linear nonlinear regressions applied generate models single variable including normalized difference vegetation index radar coefficient models compared via three accuracy metrics according results sar models generally show better accuracy optical models models show greatest accuracy among models model combination advanced thermal emission reflection european remote sensing satellite sar synthetic aperture radar image least root mean square rmse least mean absolute error greatest correlation coefficient results indicate estimated integrating optical sar imagery four maps derived illustrate distribution study area total study area estimated
exploratory study utilized concurrent mixed methods design investigate parents respond engaging forms childrens prosocial behavior whether prosocial behaviors likely receive reinforcement whether reinforcement associated specific types prosocial behavior parents preschoolers completed questionnaire regarding childs general provided open ended responses prosocial completed questionnaire assessing reinforcement open ended responses showed reinforcement highly variable across parents prosocial behaviors across open ended response option formats social reinforcement responses parent approval character attributions showing love emerged common reinforcement responses prosocial behavior similar relationships behaviors results suggest multiple ways parents respond child prosocial behaviors many seem attempts encourage
contrast high resource countries maternal mortality seen increase united states caring pregnant women cardiac arrest prove uniquely challenging given event coupled physiological changes pregnancy optimization efforts warrants special attention described american heart associations scientific statement maternal cardiac arrest current recommendations address variety topics ranging basic components chest airway management complexities operational challenges involved maternal cardiac arrest
paper investigate hub location planning mixed integer nonlinear programming model formulated optimally locating fail site specific probability objective determine location assignment demand nodes minimize expected demand weighted travel cost plus penalty fail linear version model developed using specialized flow network called probability lattice evaluate compound probability terms search algorithm proposed find optimal near optimal solutions large problem instances parallel computing strategy integrated search process improve performance experimental results carried several benchmark instances show efficiency linearized model heuristic algorithm compared standard hub median model potential hub failures model produces solutions serve larger numbers customers lower cost per customer
work aims giving guidelines assess impact performance indicators organisations performance measurement systems usually introduced organisations order monitor goal achievement allocate resources implement strategy however implementation performance indicators generate alteration rational behaviour monitored structure risk impact always present considered carefully order preserve organisation counter productive effect present analytical work reference model proposed first step model considers organisational dimensions indicator exert influence method makes use four kaplan balanced perspectives order identify dimensions indicator exert impact previous works reported scientific literature provide operational models impact analysis whereas proposed model linked operative procedure order support management make analysis aim make impact analysis less complex structuring sequence predefined steps proposal supported practical examples
consider scalar balance law strict convex flux paper study stability shock scalar balance law shift function based relative entropy result works provides simple proof proof
nowadays regional industry lacks human resources pressure created labor market high value economic projects tend loaded teaching research administrative tasks students tend use electronically devices like tablets mobile phones learning sessions context universities rely technologies like learning management systems massive open online courses generative learning objects auto generative learning objects auto generative learning objects pedagogical patterns generated content based random numbers fulfill learning objectives many online learning resources available containing interactive presentations several learning objectives learning resources hard reuse even modify adapt discipline needs needs access source code programming knowledge change test deploy etc paper focus computer science disciplines needed regional industry namely data structures algorithms show build several auto generative learning objects order assess knowledge class students start design generic models assess generated content created help tool based meta programming afterwards deploy content consumed students finally evaluate assessed results discuss approach students perspective
primary ovarian insufficiency clinical syndrome defined functional potential ovaries prior years consequences potentially serious long term fertility reproductive health general health early menopause article provides updated review different factors pathogenic mechanisms lie behind current novel strategies management challenging disease aimed primary prevention adverse effects estrogen deficiency infertility related early loss ovarian function considered multifactorial heterogeneous condition wide spectrum causes cytogenetic autoimmune infectious metabolic causes women affected isolated still appear exact underlying pathology remains unknown early prediction risk prevention detrimental consequences terms general health determination characteristics risk assessment population important prediction prevalence general population widespread consequences general health fertility challenges remain modalities assessment management complex condition review primarily focuses key questions recommendations clinical practice regarding assessment management women diagnosed therefore article provides updated review novel findings regarding diagnosis management challenging disease
currently many brazilian threatened extinction resulting habitat loss intense harvesting pressure value plants therefore genetic diversity remaining populations fundamental survival species natural environments order inform conservation strategies study evaluated genetic diversity structure populations sample consisted individuals populations atlantic forest northeastern brazil evaluated using markers genetic variability assessed molecular variance diversity indexes clusters genotypes bayesian analysis tests genetic bottlenecks polymorphic loci genetic diversity varied index ranged significant genetic differentiation populations broken vertical bar resulted division populations five groups based log likelihood bayesian analysis found significant positive correlation geographical genetic distances populations indicating isolation distance patterns allelic diversity within populations suggest occurrence bottlenecks populations therefore order maintain genetic diversity species conservation spatially distant groups necessary
background micrornas mirnas small noncoding rnas whose function modulators gene expression crucial proper control cell growth although many micrornas found express central nervous system cns role regulatory networks involved function pathological process nerve cells just emerging present study possible mechanisms one neuronal mirnas mir affected growth nervous cells investigated using vitro cell line model methods expression pattern mir treated human glioma cell lines detected northern blotting situ localization effect mir proliferation apoptosis human glioma cells analyzed assay flow cytometry analysis addition identification target gene mir studied dual luciferase activity assay analysis results found differential expression mir trans retinoic acid treated human glioma cell lines regulation mir partially restored cell viability inhibited cell apoptosis cells treated regulation decreased human glioma cells proliferation enhanced sensitivity human glioma cells induced apoptosis addition found inverse relationship expression cell apoptosis related protein bcl modifying factor mir interact untranslated region utr conclusion findings indicate overexpression promotes human glioma cell proliferation inhibits induced cell apoptosis low expression mir cells induced apoptosis play important role process mir influencing cell apoptosis copyright karger basel
pattern programming framework enables programmers create pattern based parallel mpi programs without writing mpi message passing code implicit patterns purpose framework simplify message passing programming create better structured programs based upon established parallel design patterns focus developing teaching parallel programming paper covers main features describes experiences using parallel programming classes
proteomics passed tremendous development recent years development ever sensitive fast precise mass spectrometry methods dramatically increased research biology mitochondria prominent involvement kinds diseases ageing mitochondrial proteomics review substantial findings progress proteomic analyses human cells tissues recent past one challenge investigations human samples medically founded limited access human material increased sensitivity mass spectrometry technology aids lowering new approaches like generation induced pluripotent cells somatic cells allow produce patient specific cellular disease models great potential describe human sample types accessible review status human mitochondrial proteins discuss proteins dual localization mitochondria cellular compartments describe status developments pertinent mass strategies use databases bioinformatics using selected illustrative examples draw picture role proteomic analyses many disease contexts inherited disorders caused mutation mitochondrial proteins complex diseases like cancer type diabetes neurodegenerative diseases finally speculate future role proteomics research human mitochondria fields evolving technologies exploited published elsevier behalf mitochondria research society
article deals nature characteristics use benchmarking industry domestic enterprises activity current economic conditions article identifies concept benchmarking examining stages efficiency benchmarking determines economic aspects benchmarking work industry enterprise stages innovative products benchmarking modern conditions productive forces development market factors analysed market electric vehicles studied authors improved approach assess vehicles selection best technical parameters based benchmarking unlike existing ones based calculation vehicles technical specifications integral factor order establish better competitive product industry companies among evaluated aspects need taken account building plant management improve competitiveness electric vehicles identified benchmarking regarded one important area marketing strategic research enterprises automotive industry develop activities study best products marketing process proposed compared enterprises prospects study related methodological approaches formation identify market segments cars electric motor depending price quality technical characteristics
predicting engineering properties materials prior synthesis enables integration design overall engineering process context present article discusses foundation requirements software platforms predicting materials properties modeling simulation electronic levels addressing functionality verification validation robustness ease use interoperability support related criteria based requirements assessment made current state revealing two critical points large scale industrial deployment modeling namely ability describe systems compute structural functional properties sufficient accuracy expertise needed translating complex engineering problems viable modeling strategies deriving results direct value engineering process progress challenges illustrated examples structural functional materials including metal alloys polymers battery materials fluids perspectives evolution modeling software platforms show need fundamental research improve predictive power models coordination support actions accelerate industrial deployment
microbial fuel cells treat organic compounds domestic wastewater without additional procedure required remove nitrogen study developed flat panel air cathode mfc mfc comprised five mfc units connected series operated remove organic nitrogen compounds domestic wastewater short hydraulic retention time eight months operation removal efficiencies chemical oxygen demand cod total nitrogen increased reaching respectively effluent cod concentrations respectively greatest cod first second unit removal rate mfc system allowed simultaneous cod domestic wastewater although led minimal power output first unit abiotic ammonia loss found supplied potential similar short min biological nitrogen removal thought dominant mechanism removal microbial community analysis revealed near cathode like strains contributed like strains led like strains known metabolic diversity ubiquitous appeared contribute nitrogen removal anode cathode study provides proof concept mfc system promise energy sustainable wastewater treatment elsevier rights reserved
morbidity mortality bcr negative myeloproliferative neoplasm mpn patients influenced disease related complications mostly thrombotic nature pathogenesis thrombosis multifactorial particular demonstrated deregulated expression also known surface receptor integrin leukocytes role favoring platelets activation mpn patients based data investigated epigenetic status primary myelofibrosis pmf patients explore possible association epigenetic profiles two genes thrombotic risk percentage methylation pmf samples ranged range mean whereas controls methylation status clustered restricted interval range mean cases controls furthermore results showed methylation correlated thrombotic complications contrary promoter resulted cases controls previous studies showed older age mutation play role mpn patients thrombotic risk cases prognostic value variables coherent thrombotic events significantly associated age years mutation positive tests however multivariate analysis showed methylation age years independent prognostic factors thrombosis respectively taken together findings suggest possible role epigenetic regulation pathogenesis thrombotic complications pmf patients
key success surgical navigation based computer aided design computer aided manufacturing cad cam planning registration process precise adapted surgical needs however application conventional rigid skull fixed navigation star accurate registration limited use paediatric population risk unstable fixation intracranial bleeding authors describe experience non invasive reference used combination custom made resin dental registration resection rare year old patient approach appears reported literature date
fluorescent proteins known broadly used bio imaging markers molecular biology research many genes cloned species suggested multi copies genes present genomes however full complement genes single species remained unidentified study analyzed genes two species cdna sequences revealed presence multi gene family unexpectedly large number genes separated short middle wavelength emission middle long wavelength emission gene copy numbers genomes four colonies estimated total gene copies per individual shown quantitative pcr best knowledge largest sets genes per genome fluorescent light produced recombinant protein products encoded newly isolated genes explained fluorescent range live suggesting high copy multi gene family generates fluorescence functionally diverse multi gene family existed species suggested molecular phylogenetic evolutionary analyses persistence diverse function high copy number multi gene family indicate biological importance diverse fluorescence emission light absorption species
black caused one damaging diseases order investigate molecular resistance mechanisms find genes related black resistance suppression hybridization cdna library constructed using resistant line susceptible near line driver respectively total clones obtained library reverse northern blotting sequencing analysis homology searching showed clones represent unique sequences library included many defense disease resistant related genes plant gene lipid transfer protein gene expression profiles genes corresponding different functional categories monitored real time pcr results showed expression induction genes susceptible line response intense reaction delayed limited results imply regulated genes involved responses infection information obtained study used understand molecular mechanisms disease response stress
paper give solution problem point onto intersection several closed convex sets projection individual convex set known existing solution methods problem sequential nature propose highly method key idea approach original problem system semi smooth equations benefits proposed twofold fast semi smooth newton iterative technique based generalized gradients becomes applicable mechanics iterative technique almost decentralized solution method emerges proved corresponding semi smooth newton algorithm near optimal point features make overall method attractive distributed computing platforms sensor networks elsevier inc rights reserved
introduction brain derived neurotrophic factor bdnf disturbances life stress independently interaction hypothesized induce chronic pain examined whether bdnf pathway met genotype gene expression serum levels early recent life stress interaction associated presence severity chronic multi site musculoskeletal pain methods cross sectional data subjects netherlands study depression anxiety presence severity chronic multi site musculoskeletal pain determined using chronic pain grade cpg questionnaire bdnf met polymorphism bdnf gene expression bdnf serum levels measured early life stress age assessed calculating childhood trauma index using childhood trauma interview recent life stress assessed number recent adverse life events using list threatening events questionnaire results compared bdnf met carriers often chronic pain whereas differences found bdnf gene expression serum levels higher levels early recent stress associated presence severity chronic pain interaction effect found bdnf pathway life stress associations chronic pain presence severity conclusions study suggests bdnf gene marks vulnerability chronic pain although life stress alter impact bdnf chronic pain seems independent factor onset persistence chronic pain
investigate whether activation liver receptors inhibits amyloid beta beta induced inflammatory responses human retinal epithelial cells cultures human primary cells pretreated synthetic agonist vehicle incubated beta beta optimum concentrations beta determined cell viability assay pro inflammatory cytokines mcp detected real time polymerase chain reaction pcr enzyme linked immunosorbent assay elisa expression localization aging protein analyzed western blotting immunofluorescence expressions one target genes atp binding cassette transporter examined real time pcr western blotting phosphorylated transcription inhibition factor kappa alpha kappa alpha assessed western blotting negative linear relationship beta concentration cell viability evident indicating beta decreased cell viability dose dependent manner beta enhanced expression mcp cell lines mrna protein levels whereas detrimental effects upregulated expression alpha target gene affect expression beta meanwhile inhibited phosphorylation kappa alpha mediated beta stimulation activation alpha axis alleviate beta induced inflammatory responses cells beneficial effect appears associated inhibition kappa signaling pathway
parallel time integration method nonlinear partial differential equations proposed based new implementation method linear partial differential equations employing block subspace method nonlinear algorithm based implementation within waveform relaxation initial value problem solved iteratively complete time interval nonlinear terms treated source terms provided solution previous iteration iteration problem decoupled independent principle superposition decoupled solved fast exponential integration based block method new time integration demonstrated one dimensional diffusion equation viscous equation numerical experiments confirm excellent parallel scaling linear diffusion problem good scaling case nonlinear equation simulated elsevier rights reserved
past years new era smart connected devices emerged market enable future world internet things iot key requirement iot applications power consumption allow high autonomy case battery powered systems depending application devices time low power mode sleep mode wake task accomplish active mode emerging non volatile memory technologies seen attractive solution design ultra low power systems among technologies magnetic random access memory promising candidate combines non volatility high density reasonable latency low leakage integration non volatility new feature memories great potential allow full data retention complete fast wake time article explores benefits non volatile processor enable ultra low power iot devices
objectives studies longitudinally extensive spinal cord lesions focused gray matter relevant antigen abundant spinal white matter pathology characterized aimed clarify spinal white matter pathology methods analyzed spinal cord lesions eleven spectrum disorder cases also evaluated three fewer spinal cord attacks mri antibody positive patients antibody negative multiple sclerosis patients results pathological analysis revealed seven cases loss four predominantly demyelinating cases forty four lesions loss cases involved significantly frequently posterior columns lateral columns anterior columns respectively posterior central portion anterior similarly affected respectively isolated inflammatory lesions selective loss proteins present white matter frequent respectively mri indicated frequently affected anti antibody seropositive respectively antibody patients respectively involved seropositive patients respectively patients respectively conclusions frequently extensively affects spinal white matter addition central gray matter especially isolated lesions protein loss emerge spinal white matter involvement also appear early similar cerebral white matter lesions
paper presents robust battery operated contact based meter suitable measurement pipeline plant site industrial establishment meter mainly composed specially designed inductor core inductor constitutes part type logic gate oscillator change sensor position measurement pipe diameter causes small change inductance turn changes pulse frequency powered thus frequency output instrument displayed liquid crystal display embedded processor function displacement measuring diameter pipe specimen different locations computed present design range position measurement sensitivity position measurement similar reduces higher range sensitivity position measurement seems quite suitable measurement
intervention result discrepancy planned delivered affecting outcomes recipients aim explore perspective hospital staff experiences delivering nutrition intervention barriers implementation methodsa process evaluation pilot study undertaken using qualitative description sample hospital responsible delivering higher energy hospital patients participated focus groups semistructured interviews theoretical frameworks behaviour method content analysis elicited factors sub themes influencing capability opportunity motivation provide nutrition intervention thematic analysis two independent researchers explored factors themes related process interventions implementation key themes sub themes explained factors implementation nutrition intervention aspects environment patients resistance barriers implementation perceived sustainability teamwork problem solving leadership job satisfaction opportunity optimise training feedback characteristics staff including knowledge beliefs perceptions diet health job role potential influence behaviours decision making number interacting factors influenced delivery higher energy planned addressing challenges time structure patients resistance gaps knowledge misconceptions among staff enhance similar nutrition interventions future
using gpus general purpose processors revolutionized parallel computing providing large growing set algorithms massive data parallelization desktop machines obstacle widespread adoption however difficulty programming low level control hardware required achieve good performance paper proposes programming approach aims make gpu data parallel operations accessible high level libraries object oriented languages maintaining performance benefits lower level code approach provides data parallel operations collections combined express compound computations data synchronization device management handled automatically also integrates design contract methodology increases confidence functional program correctness embedding specifications program text present prototype show leads modular concise code accessible non experts still providing performance comparable hand written cuda code also describe first steps towards highlighting challenges solutions insights implementing approach different managed languages finally show runtime contract checking becomes feasible contracts executed gpu elsevier ltd rights reserved
background widespread consensus importance safe secure communication healthcare especially trauma care time limiting factor although non verbal communication impact communication individuals limited knowledge trauma team leaders communicate purpose study investigate trauma team members positioned emergency room leaders communicate terms gaze direction vocal gestures trauma team training methods eighteen trauma teams audio video recorded trauma team training emergency department hospital northern sweden quantitative content analysis used categorize team members positions leaders non verbal communication gaze direction vocal gestures quantitative data interpreted relation specific context time sequences leaders gaze direction speech time gestures identified separately registered time seconds proportions total training time results team leaders gained control important area emergency room inner circle positioned heads team using gaze direction gestures vocal verbal verbal message changes position required attention collaboration leaders voice silent expressed ambiguity non verbal communication team members took leaders tasks discussion teams leader control inner circle members seemed awareness others roles tasks knowing time space tasks needed executed deviations leaders communication increased ambiguity communication consequences teamwork communication taken needs practiced regularly just technical skills need trained simulation training provides healthcare professionals opportunity put verbal nonverbal communication focus order improve patient safety conclusions non verbal communication plays decisive role interaction trauma team members verbal non verbal communication focus trauma team training even important leaders since non verbal communication ambiguity lead errors
conclusion patients experienced short intense anxiety disorder especially initial visit patients recovered without medication successful treatment objective recent studies shown people dizziness report psychological problems anxiety aim study evaluate anxiety levels patients benign paroxysmal initial presentation follow visit compare scores control group methods patients study diagnosis confirmed history typical subjective symptom reports characteristic test roll test patients instructed complete standard forms beck anxiety inventory scale questionnaire days treatment results validity scores statistically significantly higher patients control group period validity scores beck anxiety inventory statistically significantly higher patients control group first second evaluation
ammonia key commodity chemical vital importance made industrial scale via process requires significant infrastructure place ammonia generally made large centralized facilities ammonia produced less demanding conditions potential smaller devices used generate ammonia decentralized manner local consumption proposed enabling technology purpose relatively simple scale devices meet almost level demand moreover possible cells water produce electrons anode used reduce nitrogen give ammonia cathode nitrogen air required infrastructure process supplies water air electricity latter provided hence cell ammonia production allow generated small low cost devices requiring minimal facilities review describe recent progress towards ammonia production devices summarizing also literature field comparison made various different approaches taken key remaining challenges ammonia highlighted elsevier rights reserved
anorexia nervosa illness frequently begins adolescence involves weight loss two groups adolescent girls weight recovered following healthy comparison completed functional magnetic resonance imaging task involving social evaluations allowing comparison neural activations self evaluations evaluations perspective taking self evaluations although two groups different whole brain activations anxiety body shape concerns correlated neural activity priori regions interest cluster medial prefrontal cortex dorsal anterior cingulate correlated body shape questionnaire subjects body shape concerns used area less self evaluations cluster medial prefrontal cortex cingulate also correlated anxiety anxiety associated engagement rather social terms self evaluations data suggests differences utilization frontal brain regions social evaluations contribute anxiety body shape concerns adolescents clinical follow obtained allowing exploration whether brain function early course disease relates illness trajectory adolescents successful recovery used posterior cingulate precuneus self evaluations adolescents remained suggesting neural differences related social evaluations provide clinical predictive value utilization precuneus social self evaluations key biological component achieving sustained weight recovery adolescents elsevier ltd rights reserved
output feedback dynamic control scheme proposed efficient velocity trajectory tracking tasks direct current electric motors asymptotic differentiation approach signals also introduced applied real time angular acceleration estimation novel feature signals require system mathematical model hence presented differentiation approach wide variety practical applications diverse electric power systems require signal differentiation control identification synthesis differentiation scheme considers possible practical scenario contaminated output signals reasonably small noise computer simulations results included show controller robustness reject completely unknown chaotic load torque disturbances parametric uncertainty effectiveness differentiation scheme signals elsevier rights reserved
ammonia one produced chemicals worldwide currently synthesized using nitrogen separated air hydrogen natural gas consequent high consumption fossil fuel high emission renewable path ammonia production desirable considering potential development ammonia energy carrier study reports design analysis innovative system production green ammonia using electricity renewable energy sources concept couples solid oxide production hydrogen improved reactor ammonia synthesis air also introduced supply pure nitrogen operates extremely high efficiency recovering high temperature heat reactor used develop model study performance plant operate degrees ammonia production zero emission obtained reduction power input compared equivalent plants elsevier ltd rights reserved
mhc highly polymorphic genomic region encodes transplantation immune regulatory molecules receives special attention genetic investigation important role regulation innate adaptive immune responses strong association numerous infectious autoimmune diseases mhc locus first discovered mouse past years studied intensively mice humans however recent years species emerged important advanced experimental animal models biomedical research mhc important human immunodeficiency virus immunodeficiency virus transplantation studies undertaken association precise mhc genotyping methods using sanger sequencing next generation sequencing special issue immunology provide short review genomic similarities differences among human mouse mhc class class regions emphasis association class region mhc polymorphism haplotype structure function
multimedia detection joint experts group images interesting challenging work double compression one common operations occur manipulation widely studied quality second compression higher quality first compression approaches obtained effective detection results however still falls short accurately detecting second compression quality lower first compression quality originally designed content aware image widely used computer vision multimedia processing legitimate applications also used manipulation although several methods proposed detect based date detection images explored address highly challenging detection problems described proposed large feature mining based approach one hundred thousand features spatial domain transform domain developed ensemble learning used deal high dimensionality avoid occur traditional learning classifier detection study demonstrates efficacy proposed approach discriminating exposing quality low quality hence gap image
introduction emerged new method obtaining lung tissue biopsies diagnosis interstitial lung diseases now used highly specialized interventional centers shown promising results obtaining definite diagnosis method patients undergoing november june included case series study data patient demographics high resolution computed tomography patterns size number biopsies histology patterns contribution confident diagnosis complications registered results thirty eight patients underwent period contributed diagnosis patients complications observed frequent complication patients six patients local bleeding occurred procedure easily controlled catheter cases acid conclusion performing diagnostics safe feasible procedure resulted confident diagnosis cases
nsaids constitute heterogeneous class pharmacological agents widely prescribed treatment inflammation pain edema osteoarthritis rheumatoid arthritis musculoskeletal disorders class drugs proved efficacious account analgesic anti anti inflammatory activities gastrointestinal toxicity exists biggest problem associated chronic use many attempts made structurally modify conventional nsaids selective cox inhibitors based old still prevalent common belief selective inhibition cox provide safer nsaids present work thus focused synthesis derivatives one conventional non selective acid utilizing one procedure involving selective agent bis chloride synthesized compounds tested vivo inflammatory activity using rat edema assay subsequently cox code better insights mechanism action derivative moiety proved anti inflammatory potential better acid compound also highest score among synthesized compounds found hydrogen bonding hydrophobic interactions derivative followed derivative acid identified potential anti inflammatory compounds vivo silico studies
audio score framework consists two separate stages preprocessing alignment alignment commonly solved offline dynamic time method find path distortion matrix minimum cost determine relation performance score times work propose parallel online solution based client server architecture current version application implemented multi core architectures arm thus covering either powerful systems mobile devices extensive experimentation conducted validate software experiments also show framework allows achieve good score alignment within real time window using parallel computing techniques
using unique transaction database metropolitan area analytical framework finds eco labelled buildings command small significant asking transaction prices finding consistent results countries contrast studies present analysis also incorporates characteristics provide information sources demand eco labelled real separate estimation subgroups reveals price primarily driven households exhibit higher willingness pay eco labelled total amount fraction total sales price less households also shown pay higher prices eco label effect less pronounced results indicate utility savings likely account large proportion observed higher paid households suggests benefits living green building also play role elsevier inc rights reserved
study synthesized one type star shaped star shaped poly containing different arm numbers soft segment methane chain glycol hard segment proton nuclear magnetic resonance nmr confirmed chemical structure material differential scanning calorimetry dsc dynamic mechanical analysis results indicated melting temperature transition temperature trans decreased hard segment composition increase ray diffraction xrd results demonstrated increase following raised arm numbers high shape six arm star shaped wide melting temperature range resulted excellent triple shape memory effect vitro cytotoxicity assay evaluated osteoblasts blue assay demonstrates possessed good material potentially used new smart material field biomaterials
aim study evaluate thymus function mice hypertension total mice randomized control sham surgery two kidney one groups weeks surgery mice sacrificed blood kidneys harvested results reverse transcription quantitative polymerase chain reaction analysis revealed mrna levels box protein autoimmune regulator thymus tissue mice group significantly lower control group weeks expression also reduced sham surgery group weeks surgery recovered weeks later similar results observed expression signal joint cell receptor excision percentages cell subsets present study indicates impaired thymus function associated hypertension mice suggests thymus function novel target treatment patients hypertension
pid controller widely used many different areas power systems drives control automotive aerospace process control robotics recently fpga field programmable gate array become alternative solution realization digital control algorithm systems paper fpga based incremental pid proportional integral derivative controller designed simulated analysis pid control algorithm language used design software programs simulation results show effectiveness feasibility proposed method
novel type responsive star polymer based beta beta synthesized covalently conjugated enzyme impact self assembly behavior enzyme activity investigated design containing polymer beta synthesized via atom transfer radical polymerization butyl using beta multifunctional final product beta obtained via hydrolysis covalently onto responsive acid arms change conformation self assembly altered leading nanoparticles aqueous solution affecting activity immobilized results proved fluorescence spectroscopy dynamic light scattering system proves activity immobilized enzyme tailored responsive polymer holds great potential controllable delivery enzymes international union biochemistry molecular biology inc
organic chemistry required course programs chemistry biology many health science careers historically considered highly challenging course significant failure rates many science disciplines teaching organic chemistry traditionally focused unstructured centered delivery course material report details efforts transform teaching large section organic chemistry student centered approach use highly structured active learning format study authors examine student performance data homogeneous examinations course grades two groups students large public university comparison received highly structured active learning received traditional unstructured lecture organic chemistry data consist repeated cross sections different years total sample size regression propensity score matching used analyze student academic outcomes results suggest students exposed highly structured active learning organic chemistry scored statistically significantly higher total points final exam scores higher probability increase final course grade results suggest increased structure conjunction active learning improved outcomes generally students received students lowest academic achievement levels experienced gains study significant causal analysis impact highly structured active learning academic outcomes
timely precisely identify attack behaviors network without dealing large number traffic features historical data training data important research work field network security paper firstly differences entropy entropy analyzed compared order capture network traffic changes exactly entropy instead entropy proposed measure selected traffic features control chart theory used check entropy time series detecting screening anomalies three kinds network attacks also analyzed characterized behavior feature vector attack identification finally feature similarity based method used identify attacks experimental results real traffic traces show proposed method good capability detect identify attacks less computation cost evaluate attack identification method conveniently approach proposed generate simulated attack compared entropy based method experiments simulation show entropy based method much higher overall accuracy average precision average true positive rate comparison indicates proposed method powerful performance detect attacks pca based method
selection five diverse chemical structures modes action doxorubicin methotrexate four multidrug resistant cell line panels developed cancer cell lines different species human murine tissue organ skin colon origin characterized low endogenous expression multidrug resistance proteins high sensitivity anticancer agents used parental cell lines selection process resulted regulation several abc transporters confirmed number molecular cell biology methods protein expression pattern seemed mainly dependent drug used selection species tissue origin cell line cell panels used research model assess role proteins pharmacokinetics novel drugs drug formulations elsevier inc rights reserved
avian virus subgroup oncogenic virus causing myeloid tumors interleukin multifunctional pro inflammatory interleukin involved many types cancer previously demonstrated expression induced following infection aim study characterize mechanism induces expression role tumor development results demonstrate infection increases expression chicken peripheral blood lymphocytes vascular endothelial cells production induced envelope protein protein via kappa mediated signaling turn induced expression vascular endothelial growth factor vegf receptor vascular endothelial cells embryonic vascular tissues suppression using sirna inhibited induced vegf expression vascular endothelial cells indicating induced vegf expression mediated vegf important factors findings suggest promote tumorigenesis indicate potentially serve therapeutic target infections
fungal infections major cause animal plant morbidity mortality worldwide effective biological therapeutics complement current antifungal drugs understanding vivo mechanisms hampered technical barriers imaging host pathogen interactions characterize fungal infection zebrafish model understand mechanism action biological antifungal therapeutics imaging transparent animals find non specific human igg enhances zebrafish vivo polyclonal anti candida antibodies enhance fungi vivo promote survival analysis suggests early strong prognostic indicator overall survival although polyclonal anti candida antibodies protect disease necessarily case individual monoclonal anti candida antibodies thus zebrafish appears provide useful model host testing biological therapeutic promotes vivo enhances protection elsevier ltd rights reserved
crystal growth technique one effective methods used growing crystals terms final product quality manufacturing efficiency popular applications crystals include light emitting diodes high frequency electronic devices heated cylindrical top bottom temperature gradient considered study investigate fluid mechanics heat transfer crystal growth reactor three dimensional large eddy simulations les results natural convection heated cylindrical reactor using commercial computational fluid dynamics cfd software ansys presented paper number defined based length scale equal ratio volume lateral area cylinder addition experiment dynamically similar geometry developed particle image velocimetry based flow visualizations carried purpose validating numerical model comparisons experiments numerical simulations showed flow patterns qualitatively similar fourier transforms velocity magnitudes selected points domain matched reasonably added interesting observation simulation existence temperature inversion potential implications choice acidic basic elsevier masson sas rights reserved
introduction dissemination multi drug resistant bacteria become major public health concern worldwide increase infections caused difficulty treating expenditures patient covered reviewed challenges contemporary opportunities rapidly infections caused century including surveillance detection identification resistance mechanisms action commentary context first critical point clinical able rapidly detect abnormal event outbreak spread surveillance tools healthcare policies therapies adapted new stochastic event certainly occur future implemented
access digital data ability use integrated computational materials engineering framework critical needs materials manufacturing innovation since start materials genome initiative several efforts launched develop resources protocols necessary robust materials data infrastructure projects yielded promising results helping uncover clarify challenges remain computational materials data network active several initiatives closely tracks others similar goals presentation reports status network projects gives brief update many others also suggests ways efforts accelerate development infrastructure
rationale menopause associated changes sex hormones affect immunity inflammation osteoporosis impair lung function lung function decline previously investigated relation menopause objectives study whether lung function decline assessed fvc accelerated women undergo menopause methods population based longitudinal european community respiratory health survey provided serum samples questionnaire data respiratory reproductive health three study waves measured follicle stimulating hormone luteinizing hormone added information menstrual patterns determine menopausal status using latent class analysis associations lung function decline investigated using linear mixed effects models adjusting age height weight pack years current smoking age completed full time education including study center random effect measurements main results menopausal status associated accelerated lung function decline adjusted mean fvc decline increased confidence interval transitional women post menopausal women compared women regularly adjusted mean decline increased transitional women post menopausal women conclusions lung function declined rapidly among transitional post menopausal women particular fvc beyond expected age change clinicians aware respiratory health often reproductive aging
migraine common primary headache disorder mechanisms underlying onset migraine attack completely understood environmental changes number factors induce migraine attacks aim study investigate relationship frequency migraine attacks allergens migraine patients without aura healthy individuals similar age gender without history headache allergy prospectively included study duration migraine frequency migraine attacks medication history symptoms attacks questioned migraine disability assessment score visual analog scale vas scores obtained allergen extracts including dust fungi insect animal epithelium food allergens applied allergy tests migraine patients healthy individuals enrolled study significant difference terms age gender median migraine disease duration number attacks month duration attacks respectively years day month mean grade mean vas score positivity allergy tests migraine group control group allergy tests positive house dust red tree olive tree wheat frequency migraine attacks higher allergy test positive patients negative ones migraine group migraine patients frequent attacks examined allergies
rationale relatively recent development medical technology practice late stage pregnancy termination practice individuals closely exposed particularly fathers researched objective current research aims fill examining experience israeli fathers whose fetuses underwent israeli policy concerning late stage termination pregnancy unique corresponds israeli social norms emphasize health general healthy children particular methods seventeen interviews men experienced fetuses carried interviews analyzed using principles outlined results results indicate mens experiences arena socially constructed limited gender roles expectations revealed themes address lack socially constructed terminology unclear definition experience mens sense protect others procedure policies regulations used exclude men experience strategies use exclude results revealed experiences men examined behaviors raising retrospectively thoughts done differently conclusion findings highlight interface personal experience social phenomenon mens two opposing positions one social expectations evident revealed themes questions fathers evident thoughts self theory useful elsevier ltd rights reserved
two main proteolytic protease proteasome recently showed inhibits exhibits whole cell activity mycobacterium tuberculosis acid human proteasome inhibitor approved cancer therapy acid compound shown drive potency human proteasome protease selectivity bacterial protease human proteasome lacking needs achieved move new anti tuberculosis lead forward study explored whether alternative influence selectivity synthesized analog containing instead acid determined bacterial human enzymes surprisingly analog retained activity active proteasome devoid activity human proteasome set peptides identified three additional compounds similarly inhibiting proteasome bacteria leaving human proteasome finally showed compounds display activity tuberculosis cytotoxicity ranging acceptable undetectable results suggest selectivity human proteasome achievable selectivity together dual targeting proteasome makes new scaffold attractive starting point optimization
aimed characterize parent experience caring infant neonatal mixed methods study performed semistructured interviews parents whose infants enrolled existing longitudinal cohort study therapeutic thematic saturation achieved interviews parent experience caring child neonatal characterized principal themes theme many families described cumulative loss throughout perinatal crisis critical neonatal course subsequent missed developmental theme families experienced infant broader family interests theme parents evolved found meaning role advocate data offer insight lived experience parenting infant neonatal primary data parents serve useful framework guide development interpretation parent centered outcomes
background heritability phenotypic molecular trait measures proportion variance attributable genotypic variance important concept breeding genetics methods available calculating heritability traits derived high throughput sequencing results propose several statistical models different methods compute test heritability measure data based linear generalized linear mixed effects models also provide methodology hypothesis testing interval estimation analyses show among methods negative binomial mixed model fit compound poisson mixed model fit variance stabilizing transformed linear mixed model outperform transformed linear mixed model fit appear robust fit estimating testing heritability scores fit computationally expensive fit performed best terms coverage confidence intervals addition applied methods microrna mirna messenger rna mrna sequencing datasets recombinant mouse panel show mirna mrna expression highly heritable molecular trait mouse top heritable features expression quantitative trait loci conclusions models methods investigated manuscript applicable sequencing experiments biological available environmental variation properly controlled fit approach assessing heritability implemented first time knowledge methods presented generation simulated sequencing data either negative binomial compound poisson mixed models provided package
bidirectional reflectance distribution function estimation one fundamental problems computer graphics computer vision related fields yet work relies conventional local two global optimisation methods estimating anisotropic ward model variants cost function introduced presented algorithms based branch bound search guarantees provide globally optimal solutions contrast traditional local optimisation methods mentioned affected setting initial parameter values experiments carried validate presented methods using anisotropic materials database
propose combining shape changing interfaces spatial augmented reality extending space interactions actuated interfaces shape changing interfaces dynamically alter physical appearance objects integration spatial augmented reality additionally allows dynamically changing objects optical appearance high detail way devices render currently challenging features high frequency texture fast motion frame combination context computer graphics established techniques increasing objects mapping extensible framework helps identify challenges two techniques benefits combination utilize prototype shape changing device enriched spatial augmented reality projection mapping demonstrate concept present novel mechanical distance fields algorithm real time fitting mechanically constrained shape changing devices arbitrary graphics furthermore present technique increasing effective screen real spatial augmented reality view dependent shape change
precision ultrasonic measurements binary gas systems provide continuous real time monitoring mixture composition flow using custom microcontroller based electronics developed instruments numerous potential applications capable making continuous high precision sound velocity measurements instrument measures sound transit times along two opposite directions aligned parallel crossing gas flow difference two measured times yields gas flow rate average gives sound velocity compared sound velocity molar composition look curves obtain binary mixture given temperature pressure look curves generated prior measurements known mixtures two components theoretical calculations combination two describe instruments performance within numerous applications atlas experiment large instruments interest areas continuous situ binary gas analysis required
stroke heterogeneous syndrome determining risk factors treatment depends specific pathogenesis stroke risk factors stroke categorized modifiable age sex race ethnicity risk factors ischemic hemorrhagic stroke hypertension smoking diet physical inactivity among commonly reported modifiable risk factors recently described risk factors triggers stroke include inflammatory disorders infection pollution cardiac atrial disorders independent atrial fibrillation single gene disorders cause rare hereditary disorders stroke primary manifestation recent research also suggests common rare genetic polymorphisms influence risk common causes stroke due risk factors specific stroke mechanisms atrial fibrillation genetic factors particularly environmental interactions modifiable previously recognized stroke prevention generally focused modifiable risk factors lifestyle behavioral modification dietary changes smoking cessation reduces stroke risk also reduces risk cardiovascular diseases prevention strategies include identifying treating medical conditions hypertension diabetes increase stroke risk recent research risk factors genetics stroke identified risk stroke also identified ways target risk populations stroke prevention
tightly single body floating devices important class offshore wave energy converters examples devices development university sweden state university usa prototypes recently tested devices equipped linear electrical generator system consists cable kept tight spring equivalent device cable also prevents away providing horizontal restoring force horizontal lesser extent vertical restoring forces nonlinear functions horizontal vertical displacements makes system nonlinear one even spring damper linear whose modelling requires time domain analysis analysis presented preceded comparison purposes simpler frequency domain approach numerical results motions absorbed power shown system consisting regular irregular waves tight cable power take modelled simplified system linear spring linear damper also system formed hydraulic piston spring different scenarios analysed elsevier ltd rights reserved
background maternal education influences skeletal growth offspring adult blood pressure height components negatively associated high income countries aim evaluate association maternal education offspring adult systolic diastolic assessing whether different height components mediate association subjects methods simple mediation modelling used evaluate maternal education offspring association estimating contribution offspring height components cross sectional sample aged study results full adjustment confounders compared participants whose mothers received low education whose mothers received high education average lower result link maternal education offspring adult height turn influenced thus maternal education association occurred indirectly height trunk leg length alternatively conclusions better maternal education influence higher leg trunk lengths offspring turn contribute prevent higher adults negative height association reported high income countries also present middle income country recent economic development
since many researchers attempted use changes natural frequencies means condition assessment large civil engineering structures bridges faced challenge decoupling frequency variations apparently caused changing operational conditions case bridge southwest england time series natural frequencies exhibit diurnal variations resulting combination thermal loading effects need compensated dynamics based assessment examining monitored data several years effects traffic mass characterised compared operational effects temperature changes appear greater influence lateral modes traffic mass strong factor modes dominant factor vertical torsional modes evaluated physics based explanations variable effects vehicle mass sought using finite element model calibrated experimental data caution performance prediction structural dynamics acceptable natural frequencies model measurements achievable simulated effects changing mass observed behaviour straightforward due complexity suspension bridge structure studied
hybrid electric vehicle hev electrical generator coupled onto shaft internal combustion engine ice order process either entire given fraction traction power required vehicle wheels ice driven generator confined within vehicle exposed heating resulting ice operation high totally construction suitable machine cooling arrangement become challenging targets generator design deal due unique characteristics higher torque per volume higher efficiency compared machine topologies axial field permanent magnet machine topology selected min rated generator prototype utilized hev drive train paper describes original solutions adopted design hev generator reports experimental results taken prototype machine
currently known methods enzymatic beta synthesis enzymes heterogeneous used purpose presented published reports advances field enzymatic synthesis selected antibiotics belonging groups acids acids summarized present review key conditions parameters processes form concentration precursor compounds solvent type temperature etc analyzed compared guidelines optimization beta synthesis given present review use wide range readers enzymology biotechnology experts
national institute occupational safety health expanded research program investigating agricultural injuries data supplementary data system sds maintained labor statistics department labor indicate injuries back lower extremities agricultural workers quite common injury data sds examined agricultural employees years states consistently provided records year year period total injuries reported sds agricultural industry groups included study classified sprains strains analysis data indicate workers industries within major crop production agricultural services increased potential sustaining strain injury
real time identification tracking joint positions people achieved shelf sensing technologies microsoft camera based systems computer vision however tracking constrained systems field view people person camera view position longer followed sight addresses occlusion problem depth sensing tracking systems new tracking infrastructure provides human skeleton joint positions occlusion combining field view multiple using geometric calibration affine transformation verified techniques accuracy system evaluation consisting participants stationary position motion two positioned parallel degrees degrees apart results show skeleton matching accurate within within persons personal space realistic scenario study groups two people quickly occlusion resolved participants api developed allow distributed access occlusion free skeleton joint positions contribution provide system open source
study explores factors moderate first person perception socially desirable messages behavioral consequences perceived self perceptual disparity total participants watched truth completed survey thereafter participants acknowledged receptive film others acted perceived difference supporting distribution film message perceived message quality sensation value sensation seeking tendency issue knowledge affected assessments perceived effect self others differently also increased willingness take action stop global warming
article describes distributed parameter model acoustic field fluid within bounded domain model given form abstract partial differential equations defined appropriate function space theory partial differential equations certain results linear functional analysis used formulation description state space representation problem formulated analyzed means techniques
background uterine affect women menopause account billion annual healthcare costs type diabetes associated protection prior studies evaluate relationship tested association risk large clinical population potential differences due medications interaction race methods nested case control study derived clinical cohort outcome case control status exposure outcomes exposure classified using validated electronic medical record algorithms logistic regression adjusted covariates used model association diagnosis risk secondary analyses performed evaluating interaction exposure race exposed subjects medication taken results identified subjects outcomes cases controls diabetic non diabetic observed significant interaction exposure race adjusted models interaction race stratified analyses demonstrated protection exposure risk among european americans adjusted odds ratio aor african americans aor also observed protective effect regardless type medication taken slightly protection among subjects insulin treatments european americans aor african americans aor conclusions data conducted large population cases controls support prior studies found protective association diabetes presence risk modified race protection exposure observed regardless medication type slightly protection among insulin users mechanistic research larger cohorts necessary potential role risk
paper adaptive synchronous rectifier driving scheme llc resonant converters using ripple counter concept proposed along two methods implementation proposed scheme drain source voltage sensed detect body diode conduction based time tuned eliminate body diode conduction one proposed implementation time every switching cycle based ripple detection another proposed implementation time every switching cycle based ripple counter suitable high frequency llc converters proposed driving scheme simple implementation requires low cost digital controllers occupies controller resources importantly since digital controllers already widely adopted control llc converters proposed adaptive driving method embedded digital controllers little extra cost furthermore integrate proposed driving method closed loop control explained details experimental results demonstrated llc converter microcontroller llc converter ripple counter
researchers extensively documented sociodemographic predictors race gender attitudes mechanisms attitudes formed change despite growing recognition important status characteristic sexual orientation received little attention predictor americans race gender attitudes using nationally representative data american national survey time series study compare lesbian gay bisexual peoples attitudes sexuality race gender attitudes people hold significantly attitudes sexuality race gender even upon controlling powerful sociodemographic determinants social attitudes however substantial proportion sexual orientation gaps attitudes especially race gender explained peoples relatively political ideology findings provide evidence necessity incorporating sexual orientation future assessments americans social political attitudes elsevier inc rights reserved
objective physicians ethical legal identify abused children protected harm simultaneously required think broadly objectively differential diagnoses medical literature examples medical diseases mimic abuse potentially leading subsequent harm children families conclusion review highlights common uncommon diseases mimic physical sexual abuse children
authors previously shown many traditional approaches operational modal analysis struggle properly identify modal damping ratios bridges traffic loading due interference caused driving frequencies traffic loads paper presents novel methodology modal parameter estimation overcomes problems presented driving frequencies significantly improves damping estimates methodology based finding power spectral density given modal coordinate dividing modal separate regions left right side spectra modal coordinates found using blind source separation algorithm curve fitting technique developed uses optimization find modal parameters best fit side spectra specifically pattern search optimization method combined clustering analysis algorithm together employed series stages order improve estimates modal damping ratios method used estimate damping ratios simulated bridge model subjected moving traffic loads results method compared established methods frequency domain decomposition methods found accurate reliable even modes distorted altered driving frequencies elsevier ltd rights reserved
aims clarify effects lactobacillus quality life clinical symptoms functional mechanisms patients irritable bowel syndrome ibs methods results patients administered daily weeks ibs severity index score significantly improved compared placebo group improvement accompanied reduction health related worry changes intestinal microbiota gene expression profiling peripheral blood showed treatment significantly regulated genes related eukaryotic initiation factor signalling eighty two genes regulated ibs patients compared healthy controls expression genes exhibited dependent increase associated improvement ibs severity majority restored genes related signalling conclusions administration potential candidate therapeutic option patients ibs significance impact study although probiotics proposed benefit ibs patients objective clinical evidence elucidation functional mechanism remain insufficient study demonstrated administration influences ibs patients subjective objective evaluations gene expression profiling provided insights functional mechanism
paper approaches problem output power prediction wind park end called wind deficiency factor turbine wind direction sector identified using past data identification done using effective wind speed concept establish link output power wind turbine meteorological mast measures terms wind speed direction based forecast wind speed direction wind park simulator uses previously identified deficiency factors computes future output power time simulations show feasibility proposed approach elsevier ltd rights reserved
considered important biochemical technology oriented studies modeling functionality sensors extensively studied studies lack analysis errors present measurements impacts errors measurements mostly unknown paper discuss errors caused amplifier measurements dry sensor information especially useful evaluating reliability measurements
limiting post weaning intake young rabbit known improve resistance digestive disorders whereas degradation housing hygiene assumed negative impact health study aims providing insights mechanism digestive health preservation regarding host growth immune response symbiotic digestive microbiota factorial design weaning day day set intake restricted intake high low hygiene housing per group day day animals group subcutaneously assess specific immune response blood sampled days age determine total anti immunoglobulin type igg levels bacterial community explored per group genes coding ribosomal rna whereas volatile fatty acid concentrations measured characterize activity reduction feed intake reduced growth improved feed conversion ratio whereas degradation hygiene conditions slightly decreased feed intake fed rabbits poor hygiene conditions affect weight gain feed conversion improved day restricted feeding led lower mortality day day whereas degraded hygiene conditions decreased overall morbidity reduced intake low hygiene conditions housing affected microbiota composition especially dominant genera belonging family moreover low hygiene associated higher ratio total increased decreased unit respectively feed restricted rabbits neither specific anti igg affected treatments total igg concentrations highest animals raised poor hygiene conditions days restriction decreased days restriction high hygiene conditions conclusion degradation hygiene conditions failed induce systematic specific inflammatory response rabbit reduced morbidity instead results suggest microbiota composition helpful source biomarkers digestive health
large array resistive sensors found variety applications industrial instrumentation medical wearable applications large array sensors several non limit accuracy readout circuit paper analyzing crosstalk error caused input offset voltage input bias current operational amplifier novel double sampling technique proposed considerably reduce error spice simulation results array confirm omega resistance proposed technique decrease maximum relative error furthermore measurement results array confirm resistance value omega measured proposed technique reduce error
internet things promises continuous flow data traditional database data mining methods applied paper presents novel variant known self organized map called ubiquitous tailored streaming environments approach allows ambient intelligence solutions using multidimensional clustering continuous data stream provide continuous exploratory data analysis average quantization error time used estimating learning parameters allowing model retain plasticity cope concept drift within multidimensional stream experiments show outperforms proposals continuously modeling concept data streams converging faster stable models underlying distribution stationary accordingly nature concept drift continuous real world data streams
background one essential aspects provision care cultural issues cultural sensitivity key cultural care aim study explore culturally sensitive care pediatric nursing care iran materials methods study conventional content analysis participants consisted nurses parents selected sampling three pediatric referral centers iran data collected using semi structured interviews field notes concurrently analyzed using method data transcribed words considered meaning units abstracted labeled compared developing categories results culturally sensitive care sick child consisted three themes cultural exposure communication cultural conflict families care cultural exposure nurses informed cultural manifestations identify understand patients families cultural respect cultural beliefs nurse used native language communication combination verbal nonverbal communication methods reach common understanding finally nurse conflict culture child family care took actions making decisions develop compliance care family culture parents harmful negotiation appropriate care conclusion understanding concept culturally sensitive care help resolving problems cultural exchanges pediatric providing cultural facilities communicate patients family increase satisfaction
purification partial enzymology characteristics polyphenol oxidase studied paper crude enzyme solution purified turn ammonium sulfate dialysis cellulose ion exchange chromatography preliminary treatments purification resulted fold enrichment molecular weight estimated similar kda exhibited sodium sulfate polyacrylamide gel electrophoresis sds page optimal conditions temperature degrees addition effects inhibitors enhanced positively increasing concentration moreover crude enzyme solution showed activity toward acid rather tri activity best substrate highest max value however oxidation related significantly data obtained research provided theoretical basis prevention enzymatic processing elsevier ltd rights reserved
sole rare finding myeloid neoplasms clinical significance largely unknown report patients isolated acute myeloid leukemia aml syndromes mds chronic leukemia primary myelofibrosis pmf aml remission seven patients large small clone patients aml acquired either disease relapse disease progression became refractory therapy died shortly thereafter median months detection patients mds pmf appeared predict poorer prognosis patients experienced disease progression transformation aml months remaining patients aml aml remission detected transient finding appear clinical impact conclude detection myeloid neoplasms presents major clone often poses high risk disease progression therapy whereas presents small clone carry clinical significance elsevier ltd rights reserved
addressing climate change impacts agriculture special challenge number factors influence extent farmers particular location adopt csa technologies study applied participatory assessment method assess farmers preferences willingness pay selected csa practices technologies diverse rainfall zones study found farmers preferences csa technologies marked differences according socio economic characteristics rainfall zones preferred technologies local farmers crop insurance weather based crop rainwater harvesting site specific integrated nutrient management contingent crop planning laser land results also indicate preferences willingness pay influenced technologies cost implementation study shows potential using participatory csa prioritization approach provide information climate change adaptation planning local level authors published elsevier ltd
landsat data increasingly used ecological monitoring research data often require preprocessing prior analysis account sensor solar atmospheric topographic effects however using data faced literature containing inconsistent terminology methods vast number approaches contradictory recommendations issues best make determining correct preprocessing workflow difficult time consuming task worst lead erroneous results address problems providing concise overview landsat sensors frequently terms methods preprocessing steps commonly applied landsat data differentiated explained including registration conversion solar correction atmospheric correction topographic correction relative correction synthesize information presenting workflows decision tree determining appropriate level imagery preprocessing given ecological research question emphasizing need tailor workflow study site question hand recommend approach landsat preprocessing avoids unnecessary steps recommend approaches data products tested easily available sufficiently documented focus specific ecological applications landsat data yet many concepts recommendations discussed also appropriate disciplines remote sensing platforms
model uncertainty saturation actuators among practical challenges controller design autonomous vehicles incorporating adaptive control anti provide convenient combination counteract challenge manuscript adaptive control dynamic anti compensator proposed autonomous underwater vehicle due industrial academic interests proposed method embedded proportional derivative integral pid controller modern technique employed cope saturation problem typical performance adaptive control system achieved absence actuator saturation performance shown degrade saturation occurred however quality adaptive controller improved combined anti compensator primarily six degrees freedom dof nonlinear motion equations vehicle derived proposed scheme applied nonlinear model performance modified system compared baseline controller effectiveness presented method presence actuator saturation considering uncertainties noise disturbance assessed verified simulation scenarios elsevier rights reserved
based processing proposed account robust false memories converging associates task deep encoding processes known enhance memory also strengthen memory increase distortions long term memory recent research demonstrated compelling false memory relatively delay invariant also occurring canonical short term memory conditions investigate contributions false memory short long delays processing depth manipulated participants encoded lists four semantically related words immediately following filled retention interval approximately min later recognition test two experiments encoding manipulation frequency false memory deep encoding increases false recognition rates confidence ratings remember know judgments similar across delays differ function processing depth results suggest shared unique processes underlie false memory short long delays
acute coronary syndrome opportunity patients reveal diseases conventional risk factors hypertension dyslipidemia diabetes mellitus etc setting systemic environment led increase risk thrombosis mortality higher among patients especially highest mortality patients elevation myocardial infarction specific conditions beyond cardiovascular pathophysiology except known risk factors thrombosis involve onset describe case year old man admitted intensive care unit chest pain case found possibility polycythemia vera janus kinase mutation underlying disease thrombosis highlighted importance recognizing polycythemia vera mutation disease like report review relationship polycythemia vera mutation
despite abundance research negative intrusive thoughts far less known positive counterparts two studies explored positive spontaneous thoughts related peoples activities soc doi associated thoughts contribute mental health study participants reported valence frequency spontaneous thoughts tend several activities obsessive predicted frequent spontaneous thoughts predicted thought positivity study participants completed measures pertaining physical activity spontaneous thoughts mental health predicted positivity spontaneous thoughts physical activity predicted frequency physical activity positivity spontaneous thoughts physical activity mediated relationship indices mental
article examines support cultural preservation predictor support entertainment media three countries saudi arabia united country greater support cultural preservation positively associated support belief done preserve cultural united desire entertainment reflects ones culture history saudi arabia united positively associated support two three countries belief films harmful morality variable associated stronger support countries
health care researchers recently developed several home based sleep monitoring systems mobile applications support healthy sleep monitoring users sleep environment activities sleep quality study describes design evaluation based system automatic sleep monitoring compared recordings advantage easy placement operated users also design intelligent eye mask user friendly measuring sleep stage quality two user experiments carried demonstrate proposed system produces valid measurements sleep stage sleep quality good usability reliability sleep significantly findings suggest system also applied long term sleep monitoring sleep environment control improve users sleep quality make sleep comfortable
contrary known benefits dietary reduction adulthood life span health maternal nutrient reduction pregnancy supposed affect developing brain probably resulting impaired brain structure function throughout life decreased fetal nutrition delivery widespread developing developed countries caused poverty natural disasters also due maternal pregnancy pregnancy women years age placental insufficiency compromised development fetal cerebral structures already shown model moderate maternal nutrient reduction present study designed follow evaluate effects moderate maternal nutrient reduction individual brain aging young adulthood years human equivalent years applying novel non invasive neuroimaging aging biomarker study reveals premature brain aging years female exposed fetal effects moderate maternal nutrient reduction individual brain aging occurred absence fetal growth restriction marked maternal weight reduction birth stresses significance early nutritional conditions life long developmental programming non invasive mri biomarker allows longitudinal vivo tracking individual brain aging trajectories assess life long effects developmental environmental influences programming paradigms preventive curative treatments cerebral atrophy experimental animal models humans
first actuated robot pediatric arm rehabilitation device specifically designed provide intensive training children affected arm motor function due cerebral palsy conventional therapies paper gives comprehensive overview robot provides six actuated degrees freedom designed cover complete target group children adolescents aged years moreover new game like interface presented motivates active participation child support childs arm movements patient cooperative control strategy implemented controller enables free arm movements assistance complete guidance arm five children aged years impaired arm motor function due cerebral palsy stroke traumatic brain injury tested various training scenarios different amounts support robot settings depending therapeutic goals childrens movement capabilities preferences preliminary tests suggest setup used advanced exercise tool arm optimally challenges children adolescents severely affected functions
parkinsons disease patients show marked impairments processing action lesser extent concrete specially however still unclear extent deficits categories influenced general cognitive dysfunctions whether modulated words implied motility examine issues evaluated non patients healthy volunteers oral production task patients divided two groups depending presence absence mild cognitive impairment mci respectively participants named pictures actions varying motion content low high objects varying low high mci group showed deficits across four categories however patients exhibited selective difficulty high motion action finding previous results suggesting disturbances action related semantic information constitute alteration manifested early course diseases moreover suggests action motor circuits depend semantic elsevier inc rights reserved
background chronic alcohol intake impacts skin directly organ dysfunction modifying preexisting however chronic figure studies aim study aims correlate spectrum chronic quantum duration alcohol intake raised liver materials methods adult males ascertained fulfill royal college psychiatry criteria chronic addiction center referred dermatological enrolled cases similar number age sex matched controls data detailed history clinical examination routine liver functions tests summarized subsequently analyzed including statistically using chi square independent spearmans rank correlation tests compared data previous studies results majority units alcohol week since mean years generalized pruritus odds ratio dermatitis significantly common cases controls infections generalized major presenting complaints dermatitis present respectively exclusively cases commonly seen systemic abnormalities alcoholic liver disease diabetes mellitus peripheral neuropathy conclusion knowledge cutaneous manifestations chronic prompt depth history taking alcohol intake lead specialist referral thereby enable timely addiction serious chronic
current study examines discrete emotions function manifestation third person effect news coverage results online survey conducted employing sample undergraduate students united states south korea two countries results demonstrate third person perception negatively associated turn positively linked political participation intention losing candidate respondents third person perception positively associated anger positively associated support restrictions news south korean respondents mediation anxiety third person perception political participation intention significant losing candidate implications findings discussed
witnessed tremendous momentum second spring parallel computing recent years remember low points field years ago review led question point whether parallel computing soon reserved promising technologies never quite make article entitled death parallel computing written late prominent leader parallel computing world facing new era parallel computing learn robust history sequential computation past years study foundation established model machine profound impact history end paper examines state work parallel machine models past years parallel computing research lacking solid yet intuitive parallel machine model continue serious challenge future parallel computing paper presents attempt address challenge presenting proposal parallel machine model also discuss start work paper parallel machine model instead choices
paper present simple efficient method represent elevation functions built linear combinations features atoms features extracted either real world data sets procedural primitives combination multiple terrain models approach consists representing elevation function sparse combination primitives concept call sparse construction tree blends different features stored sparse representation allows represent complex using combinations atoms small yielding powerful compact terrain representation synthesis tool moreover present method automatically learning generating sparse construction tree model demonstrate efficiency method several applications inverse procedural modeling terrain amplification synthesis coarse
abiotic stresses especially salinity drought major limiting factors plant growth crop productivity attempt develop salt drought tolerant tomato dna cassette containing tobacco gene driven mosaic virus promoter transferred tomato via agrobacterium mediated transformation putative transgenic plants screened pcr analysis selected transformants evaluated salt drought stress tolerance physiological analysis generations integration gene transgenic plants verified southern blot hybridization transgenic expression gene verified pcr northern blotting plants transformed plants tested salt drought tolerance different levels nacl stress water supply respectively results different physiological tests demonstrated enhanced tolerance salt drought stresses transgenic plants harboring gene compared wild type plants transgenic lines showed significantly higher relative water content chlorophyll content proline content leaf expansion wild type plants stress conditions present investigation clearly shows overexpression gene enhances salt drought stress tolerance transgenic tomato plants
recent years usage based categorization possibly fundamental cognitive operation underlying acquisition use language despite increasing appeal importance categorization researchers yet offered explicit interpretations linguistic categories represented brain prototype theory especially implemented like frameworks paper discuss detail implications theoretical representations linguistic structures onto domain general models categorization first review evidence instance based based models categorization provide empirically theoretically better models domain general categorization linguistic categorization commonly cited alternative models argue three based models currently applied linguistic data model appears provide simplest straightforward account data appears fully compatible current understanding psychological capabilities operations underlie categorization behavior
mechanical properties cast iron used trunk water industry studied specimens nine different pipes service years failure bulk microstructures cast iron analysed regard graphite morphology size stress strain behaviours tension compression derived specimens loaded flexural strength data obtained specimens pipe three different locations along length around circumference pipe data analysed using methods depth visible fracture surface sample measured shown strength cast iron samples decreases increasing depth layer material reasonably uniform thickness strength reduction modest section loss local strength reduction significant samples reduction strength depth exceeds simple strength materials fracture mechanics approaches shown provide reasonable bounds data elsevier rights reserved
prognostic value left ventricular measured gated single photon emission computed tomography myocardial perfusion imaging mpi relationship electrical measured duration incompletely understood aim study therefore examine independent incremental prognostic value yet largest group patients coronary artery disease cad patients presenting mpi july normal sinus rhythm identified nuclear cardiology cardiovascular disease median years deaths occurred years kaplan meier estimates probability death among patients phase bandwidth degrees among bandwidth degrees adjustment standard clinical variables independently associated death hazard ratio per degrees confidence interval mechanical electrical together provided prognostic value afforded
assessment attack surface challenge present day dynamic networks essentially attack surface computer network subset network configuration vulnerabilities adversary use compromise target network incremental fashion large number metrics available network security risk assessment however fail measure temporal variation network attack surface overcome problem propose graph distance metrics based maximum common graph distance particular make use classical graph distance metrics quantify distance pair successive attack graphs generated dynamic network since attack graph capable successfully capturing attack surface underlying network distance pair consecutive attack graphs generated observed sampling interval indicates change network attack surface validate efficacy usability graph distance metrics proposed study tested different metrics set different network models viz flat external internal experimental results show based graph distance metrics successfully capture temporal variation attack surface also generate alert security events responsible change using graph distance metrics events cause significant change network attack surface locate dangerous hosts network effect increasing vulnerabilities hosts advantage using metrics scale graphs size independent graphs topology also evident test results performance based metrics almost similar hence computation one metric enough detect temporal variation network attack surface based graph distance metrics semantic initial conditions attack graphs thus scope improving performance sensitivity considering semantic elsevier ltd rights reserved
solar energy enormous potential solve society energy needs sustainable way notably photovoltaic systems permit obtain electricity based solar energy however issues addressed establish reliable source electrical power example low energy density one approaches improve performance systems utilize solar spectrum solar cells efficiently process high energy photon converted two lower energy trough possible use wider portion solar spectrum raising efficiency different kinds solar cells present paper reviews state art materials methods used take advantage processes solar cells discuss pros different designs solar cells main characteristics materials utilized
cell sarcoma cancers extremely rare report case cancers including described year old man squamous cell carcinoma nasal skin colon cell rich large cell lymphoma swelling multiple lymph nodes observed fine needle aspiration carried many large cells high grade nuclear abundant cytoplasm observed lymphocytes eosinophils observed background although malignant tumor suspected definite diagnosis made biopsy sample tumor cells positive vimentin negative epithelial lymphocyte melanoma markers immunohistochemistry diagnosis made immunohistochemical findings high rate atypical forms patient died months first medical examination metastasis confirmed many organs autopsy poor prognosis cases described findings added list differential diagnosis findings presented useful determining appropriate clinical management staging disease follow neoplasm authors diagnostic published wiley periodicals inc
paper presents experimental study development implementation tests control strategy applied pressure control hydraulic pumping systems strategy aims avoiding severe damage hydraulic system due water effects accomplish proposed suitable modulating control pump electric motor torque order keep pressure values safe region set operating conditions rig system developed perform experimental tests step response tests hydraulic rig system transfer function model relating pipe pressure motor speed identified subsequently applied pid controller design pid control synthesis performed using pole placement techniques performance assessed comparison pid controller adjusted using rules obtained results show proposed control strategy able assure safe plant operation even extreme operation conditions case water effect
emerging nanoscale silicon advances fabrication integration chip cmos compatible optical elements good news system designers optical network chips next generation hand hybrid electrical networks provide higher bandwidth lower latency better power dissipation considering optical electrical characteristics multicore platforms cluster based technique locally processing cores electrical clusters connected together optical experimental results show benchmark applications cluster size proves appropriate size optimizing energy delay product parameter
functional performances conventional single multi innovative flower improved right turn bypass controlled stop yield free flow signs article presents evaluations emissions air pollutants carbon dioxide nitrogen oxides particle pollution fuel consumption construction management energetic environmental costs without bypass controlled stop yield free flow suggested methodology general character applied multi parametric criterion choosing road although present paper employed case study aims research employed recent closed form formulations determine performances moreover used software estimate air emissions nine different types vehicles numerous traffic simulations carried variation maximum hourly traffic max annual traffic provided appropriate domains examined geometric layouts functional environmental terms regard generalized costs estimated year period resulted introduction right turn arms conventional one ring one entries single cost effective flows entering higher max moreover free flow bypass always provide greater capacity lower delays stop yield however extremely high max values stop controlled guarantee lower fuel consumption yield sign lower total costs
present study describes atypical cell hyperplasia week old sprague dawley rats low testosterone high luteinizing hormone levels prenatal administration day butyl phthalate days light microscopy revealed hyperplasia severely aggregated large nuclei abundant eosinophilic cytoplasm immunohistochemical analysis showed expression proliferating cell nuclear antigen vimentin many electron microscopy revealed atypical nuclei abundant free rough endoplasmic reticulum intermediate size cytoplasmic atypical tight junctions smooth endoplasmic reticulum observed
proposed ultimate evolutionary mechanism contributed increase human life expectancy see hypothesis neural hormonal system originally rooted parenting thus activated process caregiving suggested potential mechanism promotes engagement prosocial behavior towards non alike evidence theory suggest activating caregiving system positively impacts health reduce mortality helper although studies found care beneficial effects health outcomes studies focused detrimental health consequences providing care little known non forms care giving relate mortality hazards care provider using evolutionary framework examined whether caregiving within beyond family related mortality older adults survival analyses based data aging study revealed mortality hazards provided non lower provide non associations held controlling physical health age socioeconomic status various characteristics children furthermore effect caregiving extended non older adults helped beyond families potential ultimate mechanisms underlying effects discussed elsevier inc rights reserved
introduction globally adolescents young adults account new hiv infections hiv related deaths amongst adolescents increased adherence antiretroviral therapy art critical control viral replication preserve health however paucity research adherence amongst growing population adolescents living hiv aids southern africa examined levels self reported art adherence barriers adherence factors associated non adherence amongst methods cross sectional study years attending two large hiv clinics central south eastern participants self reported missed doses past week month barriers adherence completed questionnaires past traumatic events stressors disclosure depression substance use treatment self efficacy social support biomedical data retrieved existing medical records multivariate logistic regression performed identify factors independently associated self reported art adherence day recall results mean age participants years female participants reported missed art doses within past week past month commonly reported barriers adherence included travel home things feeling depressed feeling people outside within home factors found independently associated missing dose past week drinking alcohol past month missed clinic past months witnessed experienced violence home poor treatment self efficacy sex age associated adherence conclusions study nearly half reported non adherence art past month violence home alcohol use past year poor treatment self efficacy associated worse adherence sub optimal adherence major issue compromise treatment outcomes programmes specifically tailored address challenges pertinent help improve adherence art
differential susceptibility model states given genetic variant associated increased risk pathology negative environments greater average resilience enriched ones theory first implemented psychiatric genetic research also help unravel complex ways genes environments interact influence feeding behavior obesity reviewed evidence gene environment interactions influence obesity development aiming support applicability differential susceptibility model condition propose various environmental layers relevant human development considered bearing differential susceptibility model mind mother child relationship socioeconomic status individuals response important bmi food intake interacting gene variants better worse studies date investigated obesity outcomes using approach propose differential susceptibility hypothesis fact highly applicable study genetic environmental influences feeding behavior obesity risk elsevier ltd rights reserved
sub sampling based modulated wideband converter innovative low rate sampling theory sparse wideband signals draws much attention researchers however research terms implementation theory far satisfactory paper present implementation scheme complete sub sampling system proposed sampling system consists two parts lower machine mainly designed fpga four analog multiplier upper machine using computer lower machine responsible analog signal processing sampling rate far rate upper computer processes acquired data original signals exhibit experiment results designed system especially provide waveforms pseudo random sequences mixed filtered signals captured give typical recovered results experimental results show proposed implementation method system perfectly recover original wideband signal rate data music algorithm
biomass followed synthesis becoming promising pathway produce synthetic potential coupled combined cycle strategies order electricity work thermodynamic performance type system evaluated exergy analysis base case process combining biomass synthesis combined cycle defined furthermore two alternative configurations modifying base case process considered fraction tail gas increase fuel yield combustion fraction conditioned increase electricity production biomass conversion plants simulated using plus obtain data required assessment indirect gas identified main sources within three process configurations exergy destruction ratios respectively subsystem found contribute overall exergy destruction showing efficiency power generation subsystem also shows high contribution overall exergy destruction due high fuel consumption significant thermodynamic cycle depending plant configuration overall efficiencies attained case leads higher yield expense lower electricity production configuration enhances efficiency system thus thermodynamic performance contrast alternative configuration increased power generation elsevier ltd rights reserved
present radio frequency based approach gesture detection recognition using textile versions common transmission lines used microwave circuits approach allows easy fabrication input detect continuum finger positions similarly basic gestures using single measurement line demonstrate perform gesture detection thin layers providing high level versatility present types approaches additionally using small convolutional neural networks low level gestures identified high level accuracy using small inexpensive microcontroller allowing intelligent fabric reports gestures interest rather simple sensor requiring constant surveillance external computing device resulting textile smart composite applications controlling wearable devices providing simple eyes free mechanism input simple gestures
families face genetic disease risk learn complicated uncertainties health future long term basis women undergo genetic testing describe uncertainty related personal risk ones particularly risk genetic counseling setting prime opportunity practitioners help mothers manage uncertainty moment also leave session uncertainty management theory helps illuminate various types uncertainty women encounter important role communication uncertainty management informed conducted thematic analysis genetic counseling sessions practitioners mothers risk carriers mutation five themes emerged represent communication strategies used manage uncertainty addresses misconceptions introduces uncertainty related science encourages information seeking sharing family medical history previous behavior decisions minimizes probability personal risk family members risk findings illustrate critical role genetic counseling families managing emotionally challenging risk related uncertainty analysis prove beneficial genetic counseling practice generations families high risk cancer learn strategic approaches managing complex web uncertainty challenge lifetime
immune suppressive therapies target deleterious responses immune system triggered exogenous endogenous factors responses lead immune inflammatory manifestations urticaria asthma autoimmune immune mediated diseases glucocorticoids commonly used immune suppressive drugs ones supported robust evidence clinical efficacy medicine conditions combining glucocorticoids pharmacologic treatments environmental management desensitization help decrease dosages associated side effects
glutathione peroxidase glutathione reductase key enzymes antioxidant defense systems living organisms protect organisms environmental stresses investigate mechanism resistance heat stress red cdna sequences encoding glutathione peroxidase glutathione reductase two strains wild type heat tolerant cultivar successfully cloned using reverse transcription pcr rapid amplification cdna ends techniques cdna encoding nucleotides open reading frame orf nucleotides encoding amino acid residues cdna encoding nucleotides nucleotide orf encoding amino acids existed genomic dna southern blotting indicated one copy strains heat stress bioactivity mrna transcription levels upregulated cultivar compared wild type results indicate play important roles ability resist high temperatures
paper addresses impact electrode interfacial energy level alignment molecular conformation orientation surface morphology deposited organic film organic semiconductor metal interfaces varying film thickness sub monolayer multilayer currently draws significant attention regard application organic electronics clean employed substrate whereas used organic material photoelectron spectroscopy xps ups engaged investigate evolution interfacial polarization dependent near edge ray absorption fine structure spectroscopy employed understand molecular conformation orientation whereas atomic force microscopy used investigate surface morphologies films contamination layer acted layer clean substrate surface molecular layer consequence hole injection barrier height interface molecular conformation molecular orientation surface morphology thin films found depend substrate results important inferences understanding impact substrate contamination energy level alignment molecular conformation orientation surface morphology deposited thin film interfaces beneficial improvement device performance elsevier rights reserved
reviewed meta analyzed studies examined association risk child maltreatment basal autonomic activity studies examined association risk child maltreatment autonomic stress reactivity hypothesized parents risk adults show higher basal levels heart rate skin conductance lower levels variability show greater stress reactivity blunted reactivity narrative review showed evidence significance testing within across studies mixed first set meta analyses revealed risk child maltreatment associated higher baseline activity possible indication load second set meta analyses yielded differences autonomic stress reactivity risk participants low risk comparison groups cumulative meta analyses showed positive effects sympathetic stress reactivity risk factor child maltreatment found early studies whereas subsequently aggregated study reduced combined effect size null effect indication studies future directions research suggested
author analyzes process formation development research field became era computer technology highest achievements scientific field physical technical institute state university became center formation development research field east early department associate senior research associates organized group young teachers students decided start implementation major government topic developing applied issues information theory development electronic computers later year first computer set marked beginning scientific school field informatics institute implemented research field automation particle mathematical modeling use computer technology automation optimization systems organizational management university short time intense pace research field turned research education complex research center national scale research field important theoretical practical significance studies developed large schools thought conducted research promising areas employees developed logical representation language synthesis algorithms discrete automata sophisticated systems number automatic synthesis digital machines design research organizations basis computer programming system generation created anticipated numerous ideas developed generation machines electron designed launched employees powerful country one largest world basic research physics acceleration charged particles nuclear physics elementary particle physics solid state physics conducted
research morphologies isothermal kinetics growth blends studied single glass transition temperature determined composition dependence blends described equation strong interaction two polymer components confirmed melting point depression isothermal kinetics analyzed basis approach linear increase time observed compositions continued grow nearly identical growth rates increasing content size blends gradually decreased number blends increased
electrical generator integrated locally produced biomass fed clay cooking rural generator produces small amounts electricity based thermoelectric effect five deployed rural community district months study investigates power generation performance devices first days field trial determined users able charge mobile phones generator power generating performance deteriorated slightly day period due effects thermal cycling generator system whole caused eventual drying thermal reduces pressure power output one failed due mechanical problem found power produced significantly exceeded power consumed cases indicates supply appears sufficient meet average daily electrical power requirements participants study data obtained field trial used inform device second field trial elsevier ltd rights reserved
collected short video clips speakers created five types stimuli original videos audio tracks single pictures speech content figure displaying body motion participants rated stimuli brief big five personality inventory used ratings incomplete information conditions predict ratings original video condition impressions audio track condition strong predictors throughout trait ratings however cues also non negligible contributors overall impression people even make sense cues figure thus public stage judged say also move authors published elsevier inc
aim describe treatment pattern complications direct medical costs associated ankylosing spondylitis chinese urban patients methods china health insurance research association urban insurance claims database used identify patients identified patients stratified treatments comparisons established related complications direct medical costs conventional regression analyses adjusted collected patient baseline characteristics confirm impact treatments complications direct medical costs results identified patients received non steroidal anti inflammatory drugs received received plus received biologic agents received medications without indication biologic group associated lowest proportion related complications confirmed multiple logistic regression analysis odds ratio biologic group also associated highest direct medical costs median confirmed multiple generalized linear model coefficient conclusions biologics commonly used chinese patients likely due high cost future studies needed confirm potential long term clinical benefits associated biologic treatment
back pain one major musculoskeletal pain problems affect many people considered one main causes disability world lower back pain common type back pain estimated affect least adult population united kingdom time lives patients develop serious condition namely chronic lower back pain physicians carry involved diagnostic procedure determine cause cases procedure involves long task physicians visually identify abnormalities patients magnetic resonance images limited technological advances made past decades support process paper presents comprehensive literature review technological advances presents framework methodology diagnosing predicting chronic lower back pain framework combine current state art computing technologies including area artificial intelligence physics modelling computer graphics argued able improve diagnosis process
important energy reductions achieved building sector providing occupants feedback energy consumption levels recent studies link success energy feedback methods level engagement people social resulting peer pressure conform certain social norms despite promising results literature remains limited scope individual rather groups buildings limited design feedback initiatives leveraging social connections exist induced within buildings current paper addresses identified gap proposing multilayer agent based model serves test bed simulate optimize feedback methods applied building stock community city monte carlo sensitivity analyses show connecting occupants different buildings increasing engagement feedback mechanism lead energy reductions exceeding findings confirm role social networks energy conservation diffusion setting stage large scale socially engaging energy conservation initiatives american society civil engineers
new solid phase extraction mode developed separation complex interference system experiment anchored magnetic chitosan prepared without removal template molecule used extraction target analytes completion extraction process particles acted carrier retrieve functionalized magnetic chitosan sample solution showed excellent selective adsorption capacity result suggested method useful fast determination quantification characterized scanning electron microscope sem ray diffraction xrd fourier transforms infrared spectrometer ftir elsevier ltd rights reserved
background purpose significant effects clinical disease activity reported patients relapsing remitting multiple sclerosis treated delayed release phase iii define confirm trials conducted post hoc analysis integrated data define confirm evaluate effect achieving evidence disease activity patients relapsing remitting multiple sclerosis methods analysis included patients randomized twice daily placebo acetate confirm years time event method used estimate percentage patients achieving clinical relapses week confirmed disability progression analysed intention treat population new newly lesions enhancing lesions overall clinical analysed magnetic resonance imaging mri cohort results mri populations comprised patients respectively percentage patients clinical population mri cohort higher versus placebo years clinical relative reduction hazard ratio confidence interval relative reduction percentage patients achieving overall mri cohort also higher versus placebo years relative risk reduction conclusions significantly higher percentage patients treated achieved status years compared placebo
context soluble ligand predict cardiovascular events mortality patients short medium term follow studies objective evaluate relationship survival mortality patients long term follow registered patients baseline characteristics mortality correlated positively reactive protein higher survivors impact survival predictive levels influence survival mortality patients long term follow
stresses displacements relatively short thin walled beams ends subjected bending uniform loads analysed approximate solutions theory elasticity mechanics materials strength materials compared results finite element method problem fixed end discussed context two approaches analytical numerical approach
two experiments investigated cognitive skills underlie childrens susceptibility semantic false memories deese roediger mcdermott procedure deese roediger mcdermott experiment performance verbal similarities british ability scales predicted correct false recall semantic lures experiment performance test segmentation predict correct recall inversely predicted false recall lures auditory short term memory negative predictor false recall experiment experiment findings discussed terms formation traces proposed fuzzy trace theory increasing associations proposed associative activation theory elsevier rights reserved
canine influenza emerged dogs greater area time year old german dog presented referring quickly progressed death report describes macroscopic microscopic lesions molecular testing performed identify novel north american strain canine influenza covered membrane bilaterally lungs necrosis lung lobes hemorrhage congestion pulmonary edema staphylococcus isolated lung identified real time polymerase chain reaction nasal cranial lung lobes gene sequence influenza virus isolated obtained dog homology strain circulating area
objective one common complaints among postmenopausal women change sexual drive aim study assess current state sexual health spanish postmenopausal women present outpatient gynecology clinics method multicenter observational cross sectional questionnaire based study survey conducted included spanish postmenopausal women routine clinical setting outpatient gynecology clinics public private institutions throughout spain used womens sexual function questionnaire validated spain results multivariate analysis found best indicators sexual health postmenopausal women higher education working previously worked stable partner living urban area healthy habits received information menopause conclusion results indicate important provide health education information menopause complaints associated period womans life
objective aim study assess efficacy safety oral estrogen receptor ligand treatment moderate severe symptoms menopause methods randomized placebo controlled double blind dose ranging proof concept trial postmenopausal women minimum moderate severe diary reported hot per day per week randomized one five blinded dose groups placebo daily efficacy endpoints included frequency severity hot weeks treatment results one hundred participants randomized across five treatment regimens frequency moderate severe hot decreased groups treatment period mean percent change baseline placebo groups response group significantly different placebo weeks dose group significantly different placebo statistically significant differences severity hot placebo dose group treatment tolerated treatment emergent adverse events mild moderate severity conclusions daily treatment weeks resulted statistically significant reduction frequency moderate severe hot compared placebo acceptable safety profile clinical trials warranted investigate utility potential treatment symptoms
genome rice blast fungus codes two proteins terminal terminal cytochrome cyp domains respectively one confirmed synthase expression recombinant protein possessed prominent epoxy alcohol synthase activities enzyme transformed sequentially acid epoxy hydroxy acid end product occurred retention pro hydrogen suggesting hydrogen abstraction experiments gas confirmed epoxy alcohol formed likely cleavage bond formation compound subsequent double bond site directed mutagenesis demonstrated heme ligand domain required activity replacement conserved sequence revealed supported formation epoxy alcohol first member novel cyp fusion proteins devastating plant pathogens
little known association vitamin deficiency skeletal phenotypes primary patients low level associated low bone mineral density deteriorated hip geometry women asian population vitamin deficiency prevalent studies examined effect vitamin deficiency bone health primary patients investigated skeletal effects vitamin deficiency patients assessing bone mineral density bmd trabecular bone score hip geometry measured using dual energy ray absorptiometry men median age years postmenopausal women median age years cross sectional data collected subjects enrolled ongoing cohort study national university hospital march december classified patients according levels adjusting age body mass index women vitamin deficiency lower lumbar spine femur neck women sufficient levels vitamin however total hip bmd significantly different two groups hip geometry analysis cross sectional area cross sectional moment inertia section modulus also significantly lower women vitamin deficiency without significant difference found bmd hip geometry according levels men vitamin deficiency associated low bmd deteriorated hip geometry postmenopausal women
novice students participated lab study learned fundamentals computer programming python using self computerized learning environment involving min learning phase min phase students provided affect judgments approximately points every course viewing videos faces computer screens recorded learning session results indicated engagement confusion frustration frequent affective states anxiety happiness anger sadness fear rare confusion frustration engagement identified two frequently occurring pairs affective states analysis affect dynamics indicated reciprocal transitions engagement confusion confusion frustration one way transitions frustration engagement considering interaction events tandem affect revealed constructing code central activity preceded followed affective state confusion frustration followed errors preceded usage engagement followed reading coding analysis affect learning relationships control variables usage indicated frustration negative correlated learning transitions confusion frustration frustration confusion engagement positively correlated learning implications results theory affect incidence dynamics design affect aware learning environments discussed
categories often diagnostic features example person one expect law however without observing person one whether law categorize person know whether possesses particular category feature two studies showed equal individuals prefer group categories specify fewer features latent scope broader latent scope experiment participants likely classify novel part social category latent scope verbal task experiment demonstrated scope bias contexts category structure never explicitly specified elsevier inc rights reserved
multimodal passive damping mechanical structure implemented coupling secondary structure exhibiting similar modal properties considering piezoelectric coupling secondary structure electrical network suitable topology network obtained finite difference formulation mechanical equations followed direct electromechanical analogy procedure applied love theory order find electrical analogue plate passive electrical network implemented transformers inherent capacitance piezoelectric patches electrical tuned approach several mechanical modes simultaneously yields broadband reduction plate vibrations array interconnected piezoelectric patches robustness control strategy evaluated introducing perturbations mechanical electrical designs non optimal tuning considered way uniform variation network inductance effect local boundary electromechanical system observed experimentally end use analogous electrical network appears efficient robust solution multimodal control plate
background compared effect combined comparable index bis levels transcranial electric motor evoked potentials somatosensory evoked potentials brainstem surgery materials methods total consecutive patients per group undergoing brainstem surgery randomly assigned groups receiving either effect site concentration maintenance anesthesia administered groups rate min along recordings carried anterior muscles whereas cortical measured posterior tibial nerve stimulation amplitudes recorded hours induction anesthesia results bis values remained range amplitudes significantly higher group group study time points muscles induction anterior muscle whereas shorter group group differences observed latency amplitude recording techniques none patients amplitude latency changes exceeding set limit conclusions low dosages combined comparable bis values partial muscle relaxation used monitoring required brainstem surgery
part extensive group contains bioactive metabolites anti cancer potential brittle star reported cervical cancer present study conducted evaluate anticancer effect extracted crude extraction conducted using conventional method test ftir assay hela cervical carcinoma normal cells treated different concentrations fraction cytotoxicity examined mtt flow cytometry addition apoptotic induced pathway studied using caspase assay evaluation ros generation bcl mrna level crude showed cytotoxic properties hela cells without significant impact normal cells addition crude increased sub peak flow cytometry histogram treated cells ros generation caspase activity dose dependent regulation bcl treated cells demonstrated fraction trigger intrinsic apoptotic pathway cancer cells study provides valuable information apoptotic inducing effect fraction offer new insights anticancer potential promising candidate human cervical carcinoma
crucial step use dna markers biodiversity surveys assignment species genus etc sequence reads allows use information known based taxonomic names taxonomic placement dna sequences inherently probabilistic dna sequences contain errors natural variation among sequences within species reference data bases incomplete false annotations however existing bioinformatics methods taxonomic placement either exclude uncertainty quantify using metrics probability paper evaluate performance recently proposed probabilistic taxonomic placement method applying annotated reference sequence data unknown environmental data four case studies include contrasting taxonomic groups fungi bacteria mammals insects variation length quality sequences individually sanger sequenced sequences short illumina reads variation structures sizes species variation completeness reference data bases representing known species results demonstrate yields essentially unbiased probabilities taxonomic placement means quantification species identification uncertainty reliable expected accuracy taxonomic placement increases increasing coverage taxonomic reference sequence data bases increasing ratio genetic variation among taxonomic levels within taxonomic levels conclude reliable species level identification environmental samples still challenging identification uncertainty lead spurious inference key aim future research completion taxonomic reference sequence data bases making two types data compatible
conducted survival analysis competing risks estimate mortality rate predictive factors immunodeficiency related death people living hiv aids northeast brazil cohort enrolled july june monitored december two healthcare centres event interest immunodeficiency related death defined based coding causes death hiv protocol code predictor variables sociodemographic characteristics illicit drugs tobacco alcohol nutritional status antiretroviral therapy cell count baseline treatment tuberculosis follow used fine model survival analyses competing risks since regarded immunodeficiency unrelated deaths competing event estimated adjusted sub distribution hazard ratios person years observation deaths person years immunodeficiency related immunodeficiency unrelated cells risk factors immunodeficiency related death study coverage highly active antiretroviral therapy state adds baseline incidence increase specific risk hiv immunodeficiency regardless
recycling waste increasingly recognized important resource management strategy however process different pollutants including volatile organic compounds sixteen dominant total concentrations ranging presented manual process television printed circuit boards using electric heating integrated treatment technique involving spray tower electrostatic precipitation used eliminate highest removal efficiency day treatment period removal efficiency mainly due combined effect preferential elimination efficient large sized particles enhanced capture efficiency micro sized particles dominant degradation particle free treatment able remove hydrocarbons average nitrogen oxygen containing aromatic compounds average due hydrocarbons higher dielectric constants risk assessment revealed non cancer cancer risks associated significantly decreased integrated technique applied indicating treatment efficient approach atmosphere protecting human health inside waste recycling workshops elsevier rights reserved
using dot probe discrimination task subjects design examined time course attentional biases facilitated attention delayed avoidance toward thin versus fat bodies explored influence body dissatisfaction attention allocation among sample women general population three stimulus presentation times used also used neutral body shape related stimuli neutral stimuli related concept interest overcome limitations previous studies results highlighted delayed thin negatively assessed bodies among women high mechanism leads attentional bodies difficult achieve considered dysfunctional maintain reinforce results results fat bodies conclusive elsevier ltd rights reserved
paper explore leadership strategies routine work actors located across diverse array organizational settings farmers markets community farms community supported agriculture programs food seed banks local food print media combine shape sustain southern local food system use theoretical principles institutional logic show strategies routine work local food actors organizational level combine negotiate system level meaning structure within across southern otherwise seemingly fragmented social space illustrate work performed within multiple organizations organizational types converge form hybrid blended local food logic implications discussed recommendations practice proposed
events temporal figures defined segments time bounded functions importance two boundaries differ argue larger attracting attention judged important interesting explanation causal power difference follows lay notion introduction something new imply change demand effort returning previous state beginning advantage demonstrated eight studies peoples representations events historical change annual seasons people think important know started ended interested reading historical movements transitional events one season next claim interest grow importance framed follows conclusions came often identified beginning advantage actual historical importance elsevier rights reserved
psoriatic arthritis part family diseases referred diverse group chronic inflammatory disorders common clinical radiographic genetic features peripheral arthritis common symptom psoriatic arthritis patients also frequently experience involvement spine skin due diverse clinical spectrum disease severity tissues affected associated comorbidities treatment psoriatic arthritis challenging necessary mitigate risks associated disease treatment risks include disease specific treatment related psychological risks disease specific risks include associated disease progression limit functional status mitigated early diagnosis initiation treatment risks also arise comorbidities associated psoriatic arthritis cardiovascular disease obesity diabetes mellitus gastrointestinal inflammation patient outcomes affected treatment strategy employed pharmacologic agents administered additionally important physicians aware risks specific therapeutic option impact psoriatic arthritis limited skin joints common patients experience quality life impairment patients also likely depression anxiety article reviews many risks associated psoriatic arthritis provides guidance mitigating risks
dissolved organic matter systems affected environmental conditions land use thus provide important information regarding human activities surrounding landscapes optical properties water samples collected locations across river china watershed examined using vis fluorescence spectroscopy determine characteristics composition sources total nitrogen total phosphorus concentrations sampling sites exceeded national quality standards surface waters china standard class waters respectively trophic state index indicated sites investigated time redundancy analysis showed total suspended matter dissolved organic carbon turbidity strong correlation parameters exhibited weak correlations absorption high spectral slope values low specific absorption values indicated primarily comprised low molecular weight organic substances analysis excitation emission matrices contour plots showed water samples collected upstream locations exhibited acid like characteristics whereas protein like substances likely predominant samples collected areas downstream large cities patterns interpreted indicative water pollution urban industrial activities several downstream sections watershed
problems high turbidity sedimentation water pollution occur lake objective study analyze rainfall discharge relationship implications water quality conditions disk water transparency chlorophyll total organic matter tom measured september march three sites lake observe impacts surrounding catchment based representative stations rainfall data monthly rainfall march september used represent wet dry period respectively moreover sediment three sites installed september based analysis suggested rainfall magnitude land use change river catchment influenced amount materials flowing lake degrading water quality specifically higher average rainfall gave higher average total sediment load day addition water transparency decreased increasing indicates concentrations sediment nutrients reflected high amount influenced water quality conditions
aspergillus shown powerful enzymes biomass conversion sugars production costs still relatively high commercial application choice effective microbial cultivation process employed enzyme production important since affect titers profile protein secretion used proteomic analysis characterize cultivated submerged sequential fermentation processes information gained key understand differences hydrolysis steam enzyme obtained two different cultivation processes sequential process gave beta activities fold higher respectively corresponding activities submerged process greater protein diversity critical enzymes also observed analyses results helped explain fold higher yield hydrolysis non pretreated combined enzyme extracts sequential fermentation used place enzymes obtained submerged fermentation enzyme loading activity surprisingly effective compared times enzyme loadings commonly reported cellulose hydrolysis studies analyses showed consisted proteins whose role important hydrolysis substrate work combined proteomic analyses enzymology studies show sequential submerged cultivation methods differently influence titers secretion profile key enzymes required hydrolysis higher diversity auxiliary enzymes observed enzyme mixtures sequential fermentation one major reason efficient enzyme hydrolysis results using combined elsevier inc rights reserved
several studies suggest relation repeated exposure extremely thin bodies media perceptual emotional disturbances body representation anorexia nervosa study utilized exposure paradigm investigate perceptual experience modulates body appreciation adolescents compared healthy adolescents twenty patients healthy controls exposed pictures thin round models required express judgments bodies variable weight brief exposure round models increased judgments round bodies thin bodies healthy adolescents furthermore exposure round models increased judgments thin round bodies adolescents patients show change judgments exposure thin models results point weak norm based body appreciation patients elsevier ltd rights reserved
apparatus central secretory pathway involved post translational modification sorting lipids proteins mammalian cells apparatus composed organized polarized manner interconnected membrane constitute located proximity besides processing transport complex actively involved regulation entry cytoskeleton organization dynamics calcium homeostasis apoptosis representing signalling platform control several cellular functions including signalling initiated receptors located plasma membrane alterations conventional organization associated many disorders cancer different neurodegenerative diseases review examine functional implications modifications structure neurodegenerative disorders focus role fragmentation development alzheimers disease comprehension mechanism induces fragmentation downstream effects neuronal function potential contribute development effective therapies treat prevent disorders elsevier ltd rights reserved
joint homeostasis failure result osteoarthritis currently treatments alter disease progression targeting early changes cellular behavior great potential recent data show nuclear receptors contribute pathogenesis viable therapeutic targets molecular mechanisms cartilage incompletely understood study examines global changes gene expression treatment agonists four nuclear receptor implicated ppar delta ppar gamma murine articular chondrocytes treated agonists ppar delta ppar gamma underwent microarray qpcr cellular lipid analyses evaluate changes gene expression lipid profile immunohistochemistry conducted compare two differentially expressed targets control cartilage specific ppar delta knockout mice subjected surgical medial nuclear receptor agonists induced different gene expression profiles many responses affecting lipid metabolism activation downregulated gene expression proteases involved whereas decreased expression ecm components increased expression functional assays indicate increases cell triglyceride accumulation ppar gamma decrease ppar delta ppar delta antioxidant ppar delta wild type ppar delta deficient mice display increased staining collectively data demonstrate nuclear receptor activation chondrocytes primarily affects lipid metabolism case ppar delta change lead increased oxidative stress possibly contributing associated changes
fibrosis characteristic chronic kidney diseases now recognized independent predictor disease progression deposition pathological matrix walls glomerular interstitial space around predicts contributes functional surrounding vasculature recent identification major cell populations fibroblast precursors kidney tissue resident mesenchymal stem cells parietal epithelial cells enabled study process much greater depth directly fibroblast precursors cells matrix producing cells also important innate immune surveillance cells regulate inflammatory process exacerbate tissue damage release radicals cytokines contribute microvascular dysfunction aberrant wound healing responses innate immune signaling fibroblasts precursors process addition genomic genetic studies also point defective responses loci close genes involved solute transport metabolism autophagy protein handling vascular homeostasis principally epithelium endothelium upstream drivers fibrotic process indicating cellular crosstalk vital development fibrosis move beyond tgf beta inhibition central target fibrosis targeting innate immune signaling metabolic dysfunction appear increasingly alternative targets novel therapies
objectives describe clinical characteristics workers exposed ascertained diagnosis allergy specific role occupational exposure iii effect immunotherapy reducing severity allergic episodes workers exposed repeated management occupational consequences caused allergic reactions due methods observational study including patients referred regional reference hospital italy ascertained diagnosis treated performed structured questionnaire administered patients investigate occupational features allergic reactions graded according standard systems patients first episode results one hundred patients referred complete data set patients allergic reaction occurred work activities performed outdoor previously work receiving occupational activity grades reaction developed treatment resulted clinically less severe occurred first value conclusion findings confirmed clinical relevance described occupational features outdoor workers sensitization importance early identification proper management professional categories recognized high risk occupational physician supported specialists recommend appropriate diagnostic procedures prescription resulted effective treatment prevention episodes severe reactions workers proven
chronic leukemia unique disease entity overlap components syndrome myeloproliferative neoplasms clonal hematopoietic stem cell neoplasm characterized manifestations splenomegaly disease rare undergone classification review recent classification strategies diagnostic criteria focusing new insights genetic alterations unique pathophysiology disease also discuss latest molecular characterization disease including molecular factors affect current prognostic models finally focus available treatment strategies special emphasis experimental therapies elsevier ltd rights reserved
sequential measurement bcr mrna levels reverse transcription quantitative polymerase chain reaction qpcr embedded management patients chronic myeloid cml played important role remarkable improvement patient outcomes seen disease provider external quality assessment area unique perspective changing face bcr testing cml assess impact technical development international scale upon accuracy bcr testing reviewed trial data comparison participant results identified considerable variability high low levels disease including therapeutically important decision points however results converted showed less variability compared data sets also found different methods converting produce consistently different median results within data sets data suggests whilst development improved results centres still need improvement processes converting raw results order fully benefits molecular monitoring cml
advanced materials industry makes especially machinery manufacturing industry witnessed rapid development become one important part therefore material engineering colleges focus development also become one disciplines train improve practical ability adapt needs society become important part college students training thesis explores materials engineering students professional training system establishment students presented material class materials processing skills training methods manufacturing engineering training high students practical ability engineering sense
although sporadic relatively uncommon manifestation potential causing devastating outbreaks till now reported outbreaks study describes isolation molecular characterization clinically affected ethiopia outbreaks december incidence cases higher april mid june severe death without clinical signs frequently observed main age affected ranged years females affected males incidence non variants affected ethiopia assessed sequencing dna polymerase gene isolates results indicated total clinically affected genotype variant found one analysis grouping marker geographical differences showed isolates belong geographical group due fatal nature interesting examine pathogenesis species present vaccine available ethiopia therefore outbreaks controlled proper management adaptations addition important test efficacy commercial vaccines also
background intestinal adaptation augmented self renewal process increase risk malignant transformation intestine furthermore patients short bowel syndrome characteristics increase risk aim determine incidence new intestinal malignancy patients methods reviewed records adult patients identified men women ranging age years follow time diagnosis ranged months total patients followed years results cause postoperative patients malignancy radiation vascular disease crohns disease twenty eight patients received growth medications fifteen percent patients prior total twenty eight patients underwent intestinal transplantation patients previous abdominal malignancy including colorectal cancer patients thirty six received radiation therapy recurrent colon cancer found patients one lung metastases new colon cancer found patient year old woman long standing crohns disease conclusion incidence colon cancer group patients similar normal population suggests risk developing new colon cancer patients increased
iga vasculitis primarily pediatric disease rarely encountered adults adults gastrointestinal manifestations quite common yet nonspecific overlap diseases particularly crohns disease make diagnosis challenging task treatment controversial given disease course usually self limited serious complications present case iga vasculitis adult patient limited findings illustrating complexity correct diagnosis
propose new multi physics multi scale integrated computational materials engineering framework predictive simulations first multiscale application presented allows linking existing advanced material characterization methods nanoscale laboratory field scales new rock simulation framework outcome example simulation australian events found caused one process non linear progression fundamental instability australian subject long term compressive forces identify four major stages instability long wavelength plastic without localized failure first loading thrust central model followed secondary tertiary thrust away either side central thrust progression advancing towards central thrust model corroborated multiscale observations nano micro analysis deformed samples central thrust giving evidence creep fractures thrust size veins evidence intermittent shear heating events thrust width thrust known shear zone corresponding width steady state solution shear heating thrust exactly heat diffusion
indication testosterone administration older men testosterone replacement therapy male hypogonadism compared young men diagnosis management male hypogonadism older men challenging clinical manifestations androgen deficiency low testosterone levels caused modified comorbid illnesses occur medications taken frequently older men resulting greater likelihood hypogonadism subsequent inappropriate use inadequate response testosterone treatment important use systematic holistic approach diagnosis management older men hypogonadism
objective paper demonstrate integration thin film actuated microstructures realize switch triggered gas sensing algorithm based amplitude tracking devices based nonlinear response beams coated metal organic framework namely achieve high sensitivity nonlinear behaviors exploited demonstrate ideas gas sensing amplitude based tracking algorithm developed quantify captured quantity gas mems switch triggered gas using nonlinear response demonstrated noise analysis conducted shows switch high stability thermal noise proposed switch promising delivering binary sensing information also used directly activate useful functionalities
previous association studies shown mixed results acid like gene polymorphism prophylactic lithium response bipolar disorder patients present study gene expression investigated regard lithium response using scale cells caucasian patients difference expression observed among excellent responders non responders controls furthermore lithium induce significant changes expression levels days results support association expression determination lithium response patients
order operate coordinated fashion enzymes use cooperative interactions intrinsic enzymatic cycle process remains poorly understood accordingly atp number distributions various states obtained single copies mammalian double ring free solution using emission bound fluorescent nucleotides closed loop feedback trapping provided anti trap observations subunit complexes adp molecules shows peak bound adp number distribution adp whose height falls time little shift position peak indicating highly cooperative adp release process difficult observe ensemble averaged methods added produce atp hydrolysis transition state mimics adp center dot locked complex peak nucleotides lowest incubation concentrations although ensemble single molecule data show agreement standard models surprisingly observed number distributions standard models illustrating value single molecule observations mechanism complete alternative microscopic model defined present addition subunit occupancy dependent hydrolysis yields distributions consistent data
without important role played controlled psychological processes human aggression paper recommends considerable systematic attention also given operation automatic processes bringing behavior concepts impulsivity discussed briefly proposed many impulsive actions particularly antisocial ones due failures restraint initiated number experiments reviewed situational stimuli automatically heightened aggressive associations hostility displacement reactions persons association aggressive reactions media violence last mentioned studies deal especially factors affecting selection target aggression discussing findings suggested crucial situational features automatically initiated sequence determinants aggression displayed due either hostile appraisal target activation aggression related bodily reactions hostile ideas also hypothesized least one studies experienced negative affect aggression independently
advanced photovoltaic devices high performance cost ratio major concern nowadays present study investigate energetic efficiency new concept based indirect instead direct photovoltaic thermoelectric coupling using state art thermal transfer calculations shown indirect coupling interesting alternative maximize solar energy exploitation model placed photovoltaic thermoelectric systems without physical contact three components major finding showed indirect coupling significantly improve overall efficiency promising future photovoltaic developments elsevier ltd rights reserved
although shown promise psychological intervention little known effectiveness reducing one prevalent mental health problems anxiety build knowledge area conducted randomized controlled trial assigning non clinical undergraduates either four session group based intervention control self reported anxiety love self compassion assessed pretreatment posttreatment week follow relative control participants participants intervention reported higher love self compassion posttreatment higher self component self compassion follow anxiety ratings significantly differ conditions posttreatment follow study limitations directions future research discussed
neuroinflammation characterized activation glial cells observed various neurodegenerative diseases including alzheimers disease although reduction ether type brain reported patients mechanism reduction impact neuroinflammation remained elusive present study found first time various inflammatory stimuli reduced levels murine glial cells via kappa activation downregulated synthesizing enzyme phosphate increased myc recruitment onto promoter also found systemic injection lipopolysaccharide aging chronic restraint stress reduced brain contents associated glial kappa activation increase myc expression downregulation mouse cortex hippocampus interestingly reduction contents murine cortex increase activated phenotype microglial cells expression proinflammatory cytokines suggesting acceleration neuroinflammation reduction brain similar mechanism reduction also found human cell lines triple transgenic mouse brain postmortem human brain tissues findings suggest novel mechanism neuroinflammation explain prolonged progression help explore preventive therapeutic strategies treat neurodegenerative diseases
objectives urinary incontinence prevalent elderly populations dementia without dementia alzheimers disease common cause dementia urinary incontinence complicate morbidity mortality therefore study aimed evaluate prevalence annual incidence determine risk possibility main type incontinence patients taiwan methods total patients included study cohort total patients without proportion compared study cohort used matched cohort participants selected national health insurance research database sample population utilize cox proportional hazard regression evaluate risk cumulative incidence ratio curve analyze cumulative incidence function prevalence annual incidence rate calculated individual medication including initiated patients results risk higher cohort hazard ratio confidence interval cumulative incidence ratio event cohort matched cohort presents statistical significance annual incidence prevalence patients respectively conclusion present results suggest risk higher patients general population
present comprehensive study list update problem locality reference specifically present combined theoretical experimental study theoretically proven experimentally observed performance guarantees algorithms match nearly match firstly introduce new model locality reference closely captures concept runs using model develop refined theoretical analyses popular list update algorithms secondly present extensive experimental study tested algorithms traces benchmark libraries theoretical experimental bounds differ just percent new theoretical bounds substantially lower provided standard competitive analysis shows known move front strategy exhibits best performance refined competitive ratio tends degree locality increases confirms move front method choice practice elsevier inc rights reserved
paper deals hardware solution study low power active filter using card experimental platform shows labview graphical programming environment used manual automated testing analysis first order active filter operational amplifier amp hardware platform provide template build real amp circuits better understand together previous one paper developing software simulation amp filters principles main contribution paper refers software hardware solution obtaining manual frequency response curve filters often necessary measure output signal range input frequency hardware experiments allows range test voltages variable frequency input filters response measured displayed analyzed frequency scan range scan rate number test points selected front panel controls another contribution practical tool analysis response filter various input signals sine square triangular wave calculating filter gain depending amplitude measured units peak peak peak roots mean square signal level
paper try present comparative study non relational databases relational databases mainly focus presentation one implementation nosql database technology namely make comparison another implementation relational databases namely thus efficient also present advantages using non relational database compared relational database integrated field personal professional development nosql database used develop chosen variety non relational databases thanks aspects highlight article database integration framework also presented
main objective paper analyze effect heat generation radiation nanoparticle volume concentration unsteady natural convective flow past started infinite vertical plate involving nanoparticles silver aluminum oxide copper titanium oxide nanoparticle volume concentration range smaller equal taken numerical solutions governing boundary value problems obtained help laplace transform algorithm symbolic computation software maple effects heat generation radiation nanoparticle volume concentration velocity temperature profiles depicted graphically skin friction coefficient number also investigated
purpose review prevalence severity ige mediated food allergy increased dramatically last years becoming global health problem multiple lines evidence suggest epigenetic modifications genome resulting gene environment interactions key role increased prevalence atopic disease review describe recent evidence suggesting epigenetic changes mediate susceptibility food allergies discuss immunotherapy reverse effects discuss areas yet unexplored terms food allergy histone modification chromatin accessibility new techniques utilized future studies recent findings recent findings provide strong evidence dna methylation certain promoter regions box protein associated clinical reactivity changed treatment reports epigenetic changes limited also show evidence significant change based disease status treatment summary comparison epigenetic studies focusing asthma allergic rhinitis food allergy remains understudied however within next decade likely epigenetic modifications used biomarkers aid diagnosis treatment food allergic patients dna methylation specific loci shown associations food challenge outcomes successful desensitization treatment overall phenotype compared healthy controls
purpose study undertaken determine community screening program designed overcome key barriers lack awareness cost program ease access care successfully impact african american males knowledge attitudes behaviors regarding prostate cancer screening focus report knowledge date reported studies examine differences knowledge baseline level minority participants patients methods total men enrolled study month period prostate screening education offered new service existing senior health clinic addition mass offered approximately monthly various locations community including senior community centers senior complexes public housing projects screening included digital rectal examination prostate specific antigen test brief questionnaire administered client intake pretest repeated education screening participation posttest test items targeted three constructs etiology risk status clinical factors results largest difference pretest scores racial groups resulted clinical factor knowledge african american men significantly less likely caucasian men correctly identify early symptoms prostate cancer acid basic components prostate although scores initially significantly lower african american participants differences evident program involvement significant increase knowledge level men comparing pretest posttest scores significant improvement noted test item exception one key item even participation program african american men still likely believe pain first symptom prostate cancer discussion item item analysis revealed one test item program participation correct knowledge african american men still likely believe pain first symptom alert presence cancer screening program included information printed oral content emphasized importance routine screening detect cancer early stage men experience symptoms reported study examined knowledge documented similar findings respect understanding findings used direct guide educational component future screening programs hope target african american men
opioid receptor plays mandatory role action opioid drugs revealed deficiency gene difference noncoding region gene markedly affects sensitivity mice opioids noncoding region human gene yet characterized present study conducted rapid amplification cdna ends pcr identified end human mrna abundant transcript among gene transcripts poly signal located nucleotides downstream stop codon gene reverse transcription pcr analyses showed region stop codon poly signal transcribed utr identified rich regions putative transcription factor binding sites furthermore compared noncoding regions human mouse genes found apparent homology northern blotting mouse brain mrnas size band detected probe coding region probe mouse genome region corresponding human since affect gene expression present characterization noncoding region human gene lead better understanding mechanisms underlying gene regulation individual differences sensitivity opioids published elsevier
order describe accidents work hospital northern portugal analyze main impact period conducted retrospective cross sectional study information obtained records accidents work workers highest prevalence levels accidents referred superior health female workers age group years secondary education degree working shifts patient services needle main cause hands main injury location wounds frequent type injury followed sprains strains total resulted absence work sprains strains main reason preventive strategies adopted aiming promote workers health
objective estimate prevalence diabetes mellitus patients psoriatic arthritis psa comparison general population assess whether level disease activity time predicts development patients methods cohort analysis conducted patients followed large psa clinic prevalence patients compared general population ontario canada age standardized prevalence ratio calculated assessment risk factors time weighted arithmetic mean levels psa related disease activity measures assessed predictors development multivariable cox proportional hazards models used compute incident controlling potential confounders results total patients included analysis psa compared general population ontario patients included time event analysis patients observed develop based multivariable analyses joint count erythrocyte sedimentation rate predicted development conclusion prevalence higher patients psa compared general population patients elevated levels disease activity higher risk developing
process detecting plant disease human eye difficult expensive practice particularly developing countries like india designing providing fast reliable automated mobile vision based solution tasks great realistic contribution society paper mobile client server architecture leaf disease detection diagnosis using novel combination wavelet transform gray level occurrence matrix opens new dimension pattern recognition proposed mobile disease diagnosis system represents diseased patch multi resolution multi direction feature vector mobile client captures pre processes leaf image segments diseased patches pathology server reducing transmission cost server performs computational tasks feature extraction nearest neighbor classification result sent back users screen via short messaging service accuracy rate best condition part paper also focus design human mobile interface useful even farmers automatically monitor field stage just mobile android currently used run system easily extended mobile operating systems
population based studies natural history allergic sensitization rare aim study incidence persistence airborne allergen sensitization young adulthood risk factors early late onset sensitization children aged years two northern sweden invited parental questionnaire skin prick tests ten airborne allergens participated protocol repeated age years participated three examinations positive increased age years years years animals primary age years followed pollen mite sensitization low mean annual incidence positive varied per year decreased age animal stable pollen sensitization age years independently associated family history allergy urban living male sex negatively associated birth order animals home incidence age years associated family history allergy age years significantly associated early age sensitization remission sensitization uncommon conclusionthe increasing prevalence allergic sensitization age explained high incidence persistence age years factors urban living number siblings male sex lost importance
background objectives according cognitive models social anxiety disorder sad negative rumination key maintaining factor cycle social anxiety however scarcity research investigating treatment effects rumination social anxiety key cognitive variables current study aimed determine effectiveness brief intervention range cognitive processes notably negative rumination additionally predictors negative rumination state anxiety also investigated methods participants diagnosis sad randomly allocated intervention control group participants initially completed trait state based measures intervention group also completing brief cognitive intervention one week later participants completed state anxiety cognitive measures speech task finally one week post speech task participants completed trait state based measures results brief cognitive intervention positive effects cognitive processes measured different time points study levels negative rumination remained stable predictors negative rumination state anxiety consistent cognitive models sad limitations brief nature intervention temporal stance intervention delivered one week speech impacted outcomes conclusions cognitive technique potentially impact range key processes maintain sad however powerful tailored interventions needed address different processes play social situation socially anxious individuals elsevier ltd rights reserved
aim aim study evaluate life support system employed neonates pediatric cardiac intensive care unit material methods twenty five neonates required november november evaluated results median age days range days median body weight range performed cases aorta right atrial patients neck three patients performed reason two patients inability bypass seven patients respiratory insufficiency hypoxia nine patients low cardiac output seven patients median duration four days range hemorrhagic complications developed renal complications pulmonary complications infectious complications neurologic complications three mechanical complications two patients weaning successful patients eleven patients successfully discharged conclusion important treatment option performed successfully many centers around world maintain life support patients medical treatment utilization modality especially newborns congenital heart disease taken consideration
containing extra domain functional glycoprotein participating several cellular processes correlates chronic liver disease herein aim investigate expression secretion hepatocytes fatty liver disease underlying mechanisms circulating levels determined elisa clinical samples western blotting flow cytometry performed cell lines analyze whether levels associated endoplasmic reticulum stress related cell death circulating levels patients significantly higher control subjects positively related severity score cultured hepatocytes regulated expression dose dependent manner conversely cells pretreated specific inhibitor stress regulation abrogated moreover silencing enhanced release hepatocytes following treatment involved stress related cell damage findings suggest regulated level associated liver damage stress mediated cell damage contributes release hepatocytes
career researcher many ways post emergence biomedical research ecosystem originated concept years biomedical research changed nature society vaccines birth control pill new generations drugs biologics treat infections sexually transmitted diseases psychiatric disorders cardiovascular diseases led shift population demographic elderly chronically sick leading major issues provision effective affordable healthcare much worlds population present article addition providing brief appreciation contributions science authors expand three topics major interest improving quality reproducibility relevance basic biomedical research declining career opportunities graduates era decreased funding end dynamic provision universal healthcare dysfunctional systems current medical industrial complex delivering healthcare elsevier inc rights reserved
oxidative stress shown play role pathogenesis rheumatoid arthritis recent studies provided evidence antioxidant properties spa therapy purpose study investigate whether spa therapy saline influence oxidant antioxidant status patients assess clinical effects spa therapy blind randomized controlled trial randomly assigned patients ratio spa therapy plus standard drug treatment spa group standard drug treatment alone control group spa group followed week course spa therapy regimen consisting total sessions thermal mineral water pool degrees min every day except clinical biochemical parameters assessed baseline spa therapy weeks clinical parameters pain intensity patient global assessment physician global assessment health assessment questionnaire disability index disease activity score joints based erythrocyte sedimentation rate esr oxidative status parameters malondialdehyde mda superoxide radical activity antioxidant potential superoxide dismutase sod levels increased significantly spa group control group trend favor spa therapy improvements levels compared control significant clinical improvement found spa group compared control terms patient global assessment physician global assessment function disease activity esr joint count trend toward improvement pain scores spa therapy saline exerts antioxidant effect patients reflected increase levels spa therapy whether antioxidant effect contributes clinical improvements observed remains verified
family polyunsaturated fatty acids found lipid classes includes essential mammals whose deficiency associated multiple diseases multiple physiological actions play crucial role normal human metabolism maintenance healthy status clinical effects limited cardiovascular system also include maternal offspring health growth development immune system disorders cancer cognitive function psychological status multiple health organisations scientific societies recommend increasing food derived intake also suggest patients documented coronary heart disease receive minimum day acid acid preventive therapeutic effects appear largely dependent dosages employed characteristics selected patients era medicine time come move generic advice increase intake evidence based approach characterised tailored indications dietary supplement consumption approach require evaluation case case basis potential usefulness taking consideration pleiotropic effects optimal dose given indication relation international guidelines potential interactions background therapy possible side effects differences genetics dietary response supplementation cost benefit ratio likely vary function differences range fish intake diet elsevier ireland ltd rights reserved
addressing documented shortage students united choosing enter computing engineering fields computing education academy established university expose high school students key computing concepts basic computer programming hands activities motivate students enter post secondary education career opportunities computing curriculum developed class modules combined lectures lab activities providing basic computing skill development first semester android app development second semester based survey results completion additional class modules combining arduino circuit design android app development components added first semester curriculum help students better prepared second semester survey results indicated obtaining higher levels understanding computing mobile development details curriculum evaluation results described future enhancement suggested
large multicenter acute stroke trials demand randomization procedure high level treatment allocation randomness effective control overall within site imbalances minimized time delay study treatment caused randomization procedure driven randomization algorithm design study efficacy safety patients mild stroke paper compares operational statistical properties different randomization algorithms local central step forward randomization settings results show step forward randomization block design provides better performances others concern potential time delay serious central randomization system available minimization method imbalance control threshold biased probability better choice elsevier inc rights reserved
paper presents algorithm based synchronous integrator circuit mems tuning utilizing digital processing technology synchronous integral adopted drive detection signal sense axis output signal separately combining automatic gain control phase locked loop technology closed loop control drive mode implemented high precision output achieved simulation results verified effectiveness synchronous integrator circuit good agreement theoretical analysis compared algorithms advantages lower noise level better ability attenuate harmonics best hardware efficiency frequency characteristic synchronous integrator also analyzed vital bandwidth print circuit board based field programmable gate array digital circuit manufactured corresponding experiment carried experimental results show algorithm digital control system developed laboratory achieved good performance bias instability tested measured degrees angle random walk degrees root nonlinearity scale factor ppm measurement range degrees
three dimensional dynamics morphology human embryonic brain previously analyzed using modern imaging techniques morphogenesis cerebral vesicles analyzed using images derived human embryo specimens collection acquired magnetic resonance microscope equipped superconducting magnet total embryos stages without apparent morphological damage brain axes studied estimate uneven development cerebral vesicles volumes whole embryo brain respective measured using image analyzing software brain volume excluding brain tissue mean increased exponentially fold increase consistent observed morphological changes mean volume volume increased exponentially reached mean volumes respectively volumes reached respectively ratio cerebellum approximately increased ratio volume cerebral vesicles whole embryo remained nearly constant non uniform thickness brain tissue development indicate differentiation brain visualized surface color mapping thickness basal regions corresponding dorsal regions brain studied serial digital layers tissue external internal surfaces visualize core region thickening brain tissue associated development nuclei became apparent particularly visible anatomical positions mostly consistent formation basal ganglia thalamus tract confirmed comparisons serial histological sections human embryonic brain approach used study suitable convenient alternative method estimating development differentiation neural ganglia tracts findings contribute better understanding brain cerebral ventricle development authors published elsevier inc
benefits bim effective decision making improved analysis easier access information simpler green building certification provide optimised solution sustainable design construction study proposes based framework within integrated bim sustainable data model design stage building project life cycle present green building assessment tool implements proposed model aids design team generation documentation necessary obtaining green building certification extracts necessary data bim models calculating green rating provides feedback evaluation sample project run green rating score table materials category obtained validation model tool serves proof concept green data relevant certification automatically processed used inform design elsevier rights reserved
socioeconomic status ses significant risk factor negative adolescent development outcomes identifying pathways ses outcomes inform interventions adolescents demographic conducted systematic literature review eight databases studies investigating pathways ses adolescent psychosocial outcomes total articles met inclusion criteria significant risk factors identified include economic stress chaos home violence community risk factors appear mediated parent depression conflict parents parenting practices adolescent resilience interventions focusing identified risk factors recommended
coated protein gene mosaic virus gene cloned maize leaves showing mosaic symptoms reverse transcription polymerase chain reaction degraded primers results sequencing homologous comparison indicated cloned gene strain length including open reading frame orf encoding amino acids untranslated region gene constructed expression vector antisense orientation control promoter plasmid introduced induced immature embryos maize line red highly susceptible via particle results polymerase chain reaction pcr southern blotting hybridization demonstrated gene integrated maize genome plants regenerated transgenic seeds challenged artificial inoculation result transgenic showed resistance inoculated virus different extent work beneficial extending regions elite line red
implementation computer aided design computer aided manufacturing cad cam systems prosthetic simplified procedure shortened period design manufacture improved accuracy aesthetic properties dental three dimensional become adequate replacement conventional dental impressions market offers variety diverse optical cad cam systems equipped devices based different working principles main goal research determine whether precision accuracy differ among optical devices research includes five high end devices scan evaluation methodology experiment based cad inspection results obtained accuracy precision measurements tolerance levels indicate difference accuracy precision optical devices based different working principles
one known women italian history although first woman medicine italy mostly known teaching method method still used worldwide english india big obstacle communication children however need adopt non verbal communication led discovery children use innate universal language language made gestures mimic called extra verbal communication
aim evaluate brain involvement quiescent crohns disease patients fatigue using quantitative magnetic resonance imaging mri methods multiple mri techniques used assess cerebral changes quiescent patients fatigue defined least points point numeric rating scale compared healthy age gender matched controls without fatigue furthermore mental status assessed cognitive functioning based neuropsychological inventory including different domains global cognitive functioning memory executive functioning addition mood quality life scores cognitive functioning mood status correlated mri findings study groups results reduced glutamate concentrations ratios total found patients compared controls significant increased cerebral blood flow found patients min compared controls min patients encountered significantly depressive symptoms cognitive functioning scores related memory executive functioning lower patients scores showed correlation depression anxiety correlation found subcortical volumes patients controls weighted analysis addition correlation found mental status mri findings conclusion work shows evidence perfusion neurochemical mental differences brain patients fatigue compared healthy controls
objective identification biomarker prognostic value unmet need multiple sclerosis objective study investigate possible association hla genotype disease status progression based comprehensive sensitive clinical magnetic resonance imaging mri parameters measure disease effects method total patients females males underwent hla typing patient status assessed two time points year interval based clinical scores including mri evaluations quantitative brain mri values obtained whole brain atrophy lesion volume change number new lesions using predefined hla patient groups compared disease status progression global assessment achieved overall statistic assessment per measurement test mann whitney test effects multiple covariates including age gender disease duration scan parameters also evaluated using regression analysis results hla allele associated better outcomes terms new lesion count test value hla hla alleles showed global negative effect disease status although none measurements reached significance value results hla hla hla alleles inconclusive influence confounding variables statistical analysis limited elsevier rights reserved
harmonic impedance important parameter electrical power system analyses parameter applied important application island resonance detection work presents impedance estimation technique implemented real time method uses small current disturbance injection harmonic frequency uses sliding window recursive discrete fourier transform calculate magnitude phase component current voltage small current disturbance modified wavelet waveform sequential small waves one centered harmonic frequency injected network order quantify impact sequential waves injection power quality new factor defined named root mean square ratio estimation technique implemented real time using computer electrical network whose harmonic impedance point common coupling required simulated real time digital simulator
due increasing vulnerabilities security alone enough prevent cyber cyber intelligence also required prevent future attacks identify potential attacker nature biometric data collection dynamics high potential use cyber cyber intelligence paper investigate usefulness dynamics establish person identity propose three schemes identifying person typing use various machine learning algorithms combination proposed pairwise user coupling technique show performance separate technique performance combining two together particular show pairwise user coupling bottom tree structure scheme gives best performance concerning accuracy time complexity proposed techniques validated using data however techniques equally applied pattern identification problems also investigated optimized feature set person identification using dynamics finally also examined performance identification system user unlike normal behaviour types one hand show performance optimal expected
experimental studies assigned intervention measures received intervention full protocol adherence achieved rarely case public health objective study estimate effect brief counseling intervention delivered swedish dental clinics tobacco use cessation taking non adherence account conducted three secondary analyses per protocol analysis experimental counseling delivered intended contrasted usual care control treated analysis individuals compared according counseling components actually received randomization instrumental variable analysis effect intervention among always treated assigned estimated logistic regression used examine association tobacco cessation outcomes seven day abstinence three month abstinence half reduction quit attempts defined exposure intervention protocol adherence intervention group per protocol analysis closely replicated results intention treat analysis showing statistically significant effect brief counseling reduction tobacco consumption significant effect outcomes treated analysis receiving counseling components compared tobacco counseling increased likelihood half reduction instrumental variable yielded biased results conclude despite application problems conducting per protocol treated instrumental variable analyses randomized trials experimental conditions strictly standardized puts context inference based intention treat analysis authors published elsevier inc open access article license
already installed wind farms considered one promising cost effective short term strategies scale wind capacity study apply mean variance portfolio optimization theory explore alternative actions spain efficient direct outcome optimization offer optimal alternatives current wind farm generation deliver highest possible average power output yield given level supply risk different scenarios considered paper range full existing wind generation mix restricting certain amounts percentage reference region results show depending configuration portfolio optimization problem hourly fluctuations aggregate power supply reduced much retaining current level energy productivity addition level energy supply risk experienced existing portfolio spanish wind farms derive efficient boost productivity work aims providing valuable insight energy policy making direction optimally future renewable generation elsevier ltd rights reserved
genome wide association studies meta analyses implicated increased risk developing alzheimers diseases associated apoe hla hla genes study assessed whether single nucleotide polymorphisms snps within associated genes linked cognitive aging independently complex interactions older taiwanese population also analyzed interactions lifestyle genes influencing cognitive aging total taiwanese subjects aged years taiwan analyzed mini mental state examination mmse scores performed subjects evaluate cognitive functions snps tested study association cognitive aging persisted significantly bonferroni correction data also showed nominal association cognitive aging snps six key associated genes including similar additionally found interactions among cognitive aging similar moreover analysis suggested interactions lifestyle alcohol consumption smoking status physical activity social support cognitive aging similar study indicates associated genes contribute risk cognitive aging independently gene lifestyle interactions
rotational speed measurement key issue industries either process control characterization fault diagnosis electric motor driven systems used example estimate motor load belt transmission slip typically used continuous speed monitoring requiring mechanical coupling rotating shaft part speed measured given instant moments noninvasive optical used using optical reflection principles cases require reflective elements strips rotating part however user continuously measure speed given rotating part audit characterization period real time data without reflective strips introducing shaft coupled low cost commercial solution perform task example users aim continuously estimate load variation induction motor day week basis slip speed value possible conventional commercial low cost equipment unless user uses expensive online operation equipment estimating speed means input voltage current moreover rotating systems parts directly driven electric motor online equipment used practical cases even impossible couple reflective strips paper innovative low cost based proposed developed experimentally tested used easily estimate record speed time example electrical motors wind turbines
fatal anaphylaxis humans rare unpredictable note trend provide allergic individuals care plans recommend immediate use allergen ingestion suspected even absence allergic symptoms without supporting evidence base instructions use device irrespective reaction severity especially symptoms actually absent likely add parental patient anxiety greater concern possibility administered early treat initial mild symptoms progress severe anaphylaxis hard visualize scenario one deployed mild symptoms yet reaction progresses severe reaction available administration needs available rescue treatment anaphylaxis potentially valuable minutes emergency medical services activated attend food allergic individuals need provided constructive strategies support merely use authors published elsevier inc behalf american academy allergy asthma immunology open access article license
farmers along amazon river year face multiple natural hazards threaten crop production limit potential agricultural development active channel paper report findings study natural hazard related risk associated rice production bars active channel amazon river near data gathered four rice producing communities using household surveys households focus group discussions land elevations along amazon river interpretation remote sensing imagery probability extent severity rice crop estimated recent production years economic losses farming households also assessed findings point high risk crop due natural hazards suggesting good year brings rice farmers bad year near river stage conditions found problematic often cited hazard high early floods also surprisingly farmers perceptions hazards risk markedly actual experienced production years studied results provide first quantitative estimates risk due multiple natural hazards along amazon river point need assist farmers risk mitigation considerable potential amazon agricultural production
impaired insulin stimulated glucose uptake skeletal muscle serves critical role development insulin resistance whereas precise mechanism process remains unknown recently evolutionarily conserved stress inducible protein proposed play protective role obesity induced diabetes activation activate amp activated protein kinase accompanied suppression mammalian target rapamycin mtor ultimately lead autophagy induction view potential protective effects autophagy physiological pathological regulatory processes via regulation energy homeostasis metabolism investigated effects components insulin signaling pathway insulin stimulated glucose uptake induced insulin resistant showed effectively restored impaired insulin signaling moreover activity decreased response whereas significantly reversed suppressed signaling context findings revealed induced autophagy contributed restore impaired insulin signaling activation signal even presence regulation maintained insulin sensitivity glucose metabolism via dependent activation
discrepancies among independent sources information presumably identical constructs argue reliance single perspective fill need temperament questionnaires teacher parent informants adapted popular parent caregiver child behavior questionnaire short form preschool teachers informant low expected patterns consistent hypotheses drawn person perception models internal teacher scales adequate comparing favorably parent rated scales anticipated relations temperament scales emerged social competence tasks executive attention parent teacher informants confirmatory factor analyses conducted separately parent teacher scales supported familiar three factor model made cross loadings correlated errors confirmatory factor analyses parent teacher data indicated factor structures two questionnaires similar equivalent
energy efficiency carbon reduction new buildings key objectives policies aim decrease electric use nationwide particularly summer electricity usage highest case study developed test energy conservation performance economic feasibility creative intelligent open building house house focuses making improvements four key areas material electronic green building automation paper focuses applications areas electronic green building economic analysis paper electricity consumption potential energy savings based use energy conservation equipment earth tubes solar situation simulations field measurements four experimental stages economic calculations according results measurement economic analysis house demonstrated optimal energy conservation performance using earth tube fan solar exhaust house lowered indoor temperature similar degrees summer using earth tube fan instead electric increased indoor temperature much degrees terms economic benefits using energy conservation facilities installed house reduced electricity expenditures decreased emissions around per year elsevier ltd rights reserved
etiology pathogenesis parkinsons disease complicated fully elucidated important association identified inflammation study investigated role nucleotide binding domain leucine rich repeat domain containing consisting caspase cytokines family lipopolysaccharide lps induced induced rats different doses caspase inhibitor rat performed seven consecutive days rotational behavior number dopamine neurons substantia nigra mrna protein expression levels components measured days setup established results showed high mrna protein expression levels components observed injected side induced rats inhibited mrna protein expression components lps induced rats moreover number significantly decreased number neurons improved data indicate participates pathogenesis inhibiting downstream pathway caspase beta axis alleviate occurrence symptoms providing new basis prevention treatment
previous research shown young children able see agent whose eyes covered current study explored phenomenon experiment year olds see look whose eyes covered indicating demand seeing another looking another experiment year olds distinction see look facing human strong correlation childrens knowledge reciprocal adherence demand found results discussed respect childrens bias second personal encounters childrens relational concept persons elsevier inc rights reserved
studies proved addition nitrate lead reduction methane emission mechanism function involved competition effect nitrate hydrogen consumption inhibitory effect generated nitrite proliferation present study investigated alternative mechanism anaerobic methane bacteria bacteria exist therefore methane oxidized addition nitrate batch culture model used test effects addition culture substrate methane production fermentation patterns population anaerobic results showed culture detected polymerase chain reaction pcr using special primer sets addition nitrate reduced methane production relative proportions whereas increased relative proportion combined addition ammonia salt nitrate show inhibitory effect methane production accelerated nitrate removal detect culture real time pcr using special primer sets present study encourage researchers pay attention methane oxidation performed anaerobic studying strategies inhibiting methane emission
aim present study investigate regulatory relationships among hypoxia inducible factor hif microrna erythroid transcription factors cells transfected hif knockout overexpression plasmid cells divided groups negative control overexpressing interference groups cells cultured hypoxia expression mir mir mir three groups determined quantitative pcr expression levels erythroid transcription factor mrnas nuclear factor erythroid measured using qpcr protein expression studied using western blot analysis hypoxia levels mir mir mir overexpression group higher groups differences statistically significant hypoxia level mir interference group less negative control group difference statistically significant level mrna overexpression group higher negative control group however interference group level lower overexpression group hypoxic conditions level mrna interference group higher two groups hypoxic conditions mrna related levels hif mrnas negative control hypoxia higher level hif mrna overexpression group hypoxia lower mrna showed reverse association levels hif mrna interference group hypoxia higher compared differences statistically significant western blot results suggested protein expression correlated changes respective mrna transcription levels results therefore suggested mir involved regulation hematopoiesis via hif pathway cells hypoxic condition mir mir entirely dependent hif suggesting possible complex regulatory mechanisms involved hypoxia
modern cryptographic protocols require good entropy sources unfortunately many networked devices lack subsystems dedicated task potentially susceptible random number generator attacks yet systems allow software host communication ports providing option work illustrates chaotic dynamics used design sub entropy source capable rate offering multiple serial communication abilities operation based standard microcontroller exploits loop built around one analog digital converters design offers self testing features enables experimental validation recent results choice best state quantization function employ using chaotic maps
order maximize performance internal combustion engine combustion phase usually controlled track desired reference however suffering cyclic variability combustion difficulty meaningful control mean combustion phase constrain variance combustion phase indicator location peak pressure utilized real time combustion phase control research purpose proposed method ensure mean statistically tracks reference standard deviation distribution achieve first calculated based cylinder pressure sensor characteristics analyzed steady state operating condition distribution examined online using hypothesis test criterion basis presented statistical algorithm current mean applied feedback channel designing spark advance adjustment law stability closed loop system theoretically ensured according steady statistical model finally proposed strategy verified spark ignition gasoline engine published elsevier ltd
recent biological studies draw attention question variability cells refer study published cell controlled culture grows constant rate rate differ one individual another biological question address states follows individual variability growth rate influence growth speed population growth speed population measured parameter define thereafter also called literature fitness even variability growth rate among cells small distribution coefficient variation around even influence parameter still smaller influence become determinant since exponential growth speed population
acute myeloid leukemia aml characterized translocation chromosomes formation distinctive fusion transcript translocation places control promoter leading pronounced upregulation transcripts aml compared normal hematopoietic cells investigated role highly upregulated hypothesis acts competing endogenous rna micrornas mirnas away target transcripts thus contributes aml formation using publicly available aml rna seq mirna seq data available cancer genome atlas project obtained network consisting genes act competing mirnas suggested mirna among candidates previously implied cancer development players integrin cadherin wnt signaling pathways affected finally among set high interest found multiple genes previously linked aml formation conclusion study offers novel look role fusion transcript aml beyond previously investigated genetic epigenetic aberrations elsevier rights reserved
human new member atp binding cassette abc transporter family certain drugs investigate roles transporter cloned mouse mouse heart cdna library named deduced mouse protein identical human possesses features common abc superfamily found mainly expressed liver heart similar human evaluated effect acute substrate mrna expression using northern blotting non coding region probe avoid cross hybridization genes following acute infusion mrna expression significantly reduced liver injection vehicle treatment heart kidney real time quantitative polymerase chain reaction analysis confirmed reduction mrna similar reductions mrna also observed comparable amount affect mrna expression liver results suggest play role metabolism liver
research interference influence intentional electrical network important assure working reliability paper propagation model disturbances electrical network consists connected systems wireless systems established based transmission line theory equation approach propagation model straight forward analytical approach applied certain network responses voltages electrical fields obtained load wireless located network response proportions wireless parts presented
address large house building demand developing countries soil used alternative building material high availability source material ease processing low environmental impact work soil cement blocks three different contents mineral waste soil cement blocks three different contents fiber fabricated characterized tested moisture absorption resistance compression bending accelerated erosion increase compression resistance found mineral loaded whereas increase fiber lead fold increase rupture modulus results observed bending strength compression resistance increased addition mineral waste fiber american society civil engineers
background aspirin use effective prevention cardiovascular disease however patients equally responsive aspirin oxidative stress reflected iso prostaglandin alpha alpha potential mechanism failure aspirin adequately inhibit cyclooxygenase objective examine relation cause mortality concentrations urinary alpha patients stable coronary artery disease cad methods data analysis prospective study patients categorized four groups based median values alpha results patients included analysis median range age years median range values alpha respectively total patients died median follow days reference group cox proportional hazards survival analysis patients values alpha corresponding adjusting age sex patients values greater median significantly higher risk mortality compared reference group high low alpha hazard ratio confidence interval high alpha hazard ratio confidence interval findings similar adjusted comorbidities cancer kidney function ejection fraction conclusion found appears better prognostic marker mortality compared alpha suggesting aspirin resistance stronger independent determinant death cad patients treated aspirin artery copyright wolters kluwer health inc rights reserved
recent insights signaling actions inorganic dietary nitrate nitrite now suggest critical role microbiome development cardiac pulmonary vascular diseases thought end products endothelial derived nitric oxide heme oxidation nitrate nitrite now considered major sources exogenous exhibit enhanced signaling activity conditions hypoxia stress bioavailability nitrate nitrite depend enzymatic reduction nitrate nitrite unique set bacterial nitrate reductase enzymes possessed specific bacterial populations mammalian mouth gut pathogenesis pulmonary hypertension obesity hypertension cvd linked defects signaling suggesting role oral bacteria shape development formation nitrite bioactive nitrogen oxides oral supplementation inorganic nitrate nitrate containing foods exert pleiotropic beneficial vascular effects setting inflammation endothelial dysfunction ischemia injury pre clinical models traditional high nitrate dietary patterns associated beneficial outcomes hypertension obesity cvd observations highlight potential microbiome development novel nitrate nitrite based therapeutics cvd risk factors
major challenge social networking services getting users exhibit prosocial behavior active participation creating sharing content seek integrate varying sometimes conflicting explanations prosocial behaviors rooted behavior commitment theory study offers three distinct mechanisms regulate ones experience translates commitment leads prosocial behavior particular satisfaction affective commitment active participation based mechanism past investments commitment resulting alternatives form constraint based mechanism social support normative commitment users intentions moderate comments third based mechanism empirically tested model data collected actual facebook users results analysis supported proposed relationships mechanisms experiential factor mediating type commitment prosocial outcome effects rare commitment mediators outcomes common experiential antecedents commitment factors understanding mechanisms allows managers fine tune service experience promote specific prosocial behaviors meanwhile researchers benefit overarching view prosocial behavior helps combine contrast emergent perspectives theories
background develop latent classes exposure traumatic experiences age years urban community sample use latent classes predict development negative behavioral outcomes adolescence young adulthood method total participants based randomized field trial children completed comprehensive psychiatric assessments young adults reported experiences nine traumatic experiences age years used latent class analysis create latent profiles traumatic experiences latent classes used predict psychiatric outcomes age years criminal physical health problems traumatic experiences reported young adulthood results three latent classes childhood traumatic experiences supported data one class sample primarily female characterized experiences sexual assault reported significantly higher rates range psychiatric outcomes young adulthood another class primarily male characterized experiences violence exposure reported higher levels antisocial personality disorder post traumatic stress final class reported low levels childhood traumatic experiences parental psychopathology related membership sexual assault group conclusions classes childhood traumatic experiences predict specific psychiatric behavioral outcomes adolescence young adulthood long term adverse effects childhood primarily concentrated victims sexual non sexual violence gender emerged key classes trauma exposure outcomes
sustainability defined green building council achieved addressing three dimensions environment economic social research utilizes case study approach explore pre fabrication strategies impact sustainability goals construction projects addressing three aforementioned dimensions common tool lean practice often used means improve productivity reduce material labor building components controlled environment positive effect occupational safety reduced hours heavy lifting therefore concluded also addresses social dimension sustainability paper presents case study recently completed project used construction buildings north traditional method used construction south thus providing ability compare analyze comparative impact versus traditional construction goal sustainability paper discusses details process involved starting decision making way execution procurement process use building information modeling bim perceived project performance sustainability results
correlation blood pressure target organ damage vascular risk long term patient prognosis stronger measurements derived around clock ambulatory monitoring clinic daytime ones numerous studies consistently mean independent much better predictor cardiovascular disease cvd risk either means elevated sleep time sleep time hypertension diagnosed around clock much common suspected patients sleep disorders among others elderly type diabetes chronic kidney disease resistant hypertension hence medical guidelines increasingly recommend make accurate differential diagnosis hypertension versus recognize marked clinical importance adequate management sleep time ingestion time according circadian rhythms hypertension medications six different classes combinations significantly impacts beneficial particularly sleep time control adverse effects para ambulatory blood pressure monitoring prediction cardiovascular events study first prospective randomized treatment time investigation designed test conventional hypertension medications specifically target attenuation median follow outcomes trial found strategy advantageous resulting differential reduction total cvd events decrease major cvd events cvd death myocardial infarction ischemic hemorrhagic stroke study plus earlier conducted less refined trials document mean significant prognostic marker cvd morbidity mortality attenuation mean hypertension treatment strategy entire daily dose hypertension medications significantly reduces cvd risk general hypertension population vulnerable patients diagnosed chronic kidney disease diabetes resistant hypertension elsevier ltd rights reserved
cognitive behavioural functional assessment crucial longitudinal studies neurodegenerative central issues definition study population asymptomatic risk individuals dementia detection change decline assessment relevant outcomes depend quantitative measures cognitive behavioural functional status currently far available reliable protocols tools assessment europe main problems heterogeneity tools used across different european countries lack administration scoring methods across centres limited information available psychometric properties many tests currently widespread use situation makes hard compare results across studies carried different centres thus research progress particular towards contribution big data common data set present results project funded joint program neurodegenerative diseases italian ministry health project aimed providing consensus framework assessment tools applied research neurodegenerative disorders affecting cognition across europe panel european experts reviewed current methods neuropsychological assessment identified issues made recommendations neuropsychological assessment neurodegenerative europe consensus achieved general recommendations followed developing procedures tools neuropsychological assessment aim tools procedures achieve reliable data cognitive behavioural examination results study considered first step enhancing common view assessment across european countries
background periodontal therapy matrix derivative successfully used tissue regeneration altering activity various cells involved periodontal regeneration studies focused primarily clinical parameters outcome effects oral epithelial cells crucial importance order understand biology regeneration aims study investigate proliferative cytotoxic effects oral epithelial cells possible influences epithelial barrier function methods scc cells human squamous cell carcinoma cell line primary keratinocytes either treated dissolved culture medium added wells cells incubated hours proliferation rate analyzed measuring nucleotide uptake cytotoxic effects treatment sampled lactate dehydrogenase release alterations epithelial barrier function induced investigated analysis electrical resistance results statistically significant inhibitory effects malignant primary cell proliferation demonstrated culture plate wells cytotoxic effects caused detected induced significant increase barrier function conclusions investigation compares applying solution cells wells wells used solely inhibition cell proliferation evident represent suitable clinical usage furthermore induced increase primary cells results suggest enhance barrier function
background systems complex constantly adapt changing demands complex adaptive characteristics rarely considered current top approaches health system reforms aimed constrain demand expenditure growth economic focus fails address needs patients providers communities ultimately results declining effectiveness efficiency health care system health wider community needs focused complex adaptive health system represented healthcare vortex model build needs focused complex adaptive health system illustrated eastern aids relief program approaches poor kenya findings small group nurses community health workers focused care hiv aids patients work identified additional problems tuberculosis local trained run local lab services helped reach need collaboration ministry health established local hiv treatment programmes helped supplement treatment nutrition support maternal child hiv prevention adolescent counselling services addressed additional needs theory healthcare vortex indeed matches real world experiences locally developed delivered adaptive people centred health systems bottom community provider initiated approach deliver highly effective sustainable health care despite significant resource constraints
background effects radiation skin particularly patients result impaired quality life inability perform activities daily living skin care radiation therapy needed prevent treat radiation dermatitis patient adherence prescribed skin care protocols paramount optimal outcome always monitored closely objectives focus study optimize patient adherence oncology nursing evidence practice recommendations skin care radiation therapy methods multidimensional approach used enhance adherence skin care protocol outcomes measured included adherence patient satisfaction skin condition findings five interacting dimensions affect adherence health system socioeconomic therapy related patient related condition related factors self reported adherence washing protocol treatment week treatment week high implementation skin care protocol introduced study led statistically significant decrease level skin toxicity
repetitive sequence based polymerase chain reaction pcr inter simple sequence repeat pcr used molecular type pseudomonas pss strains isolated wheat plants bacterial black node symptoms grown different locations six different seed production districts japan eighteen genomic genotypes obtained combined results box pcr indicating pss population japan high genetic diversity result based logistic regression indicated population genotype significantly related seed producing district epidemic pss strains fields originated mainly seed infection study applicable future studies molecular epidemiology bacterial plant diseases multiple infection routes
impact conflict parenting outcomes education programs widely explored literature despite prevalence conflict study used outcome data sample participants took online parents course participants asked questions positive negative parenting behaviors levels conflict separation average slight increase conflict post follow simple linear regression analyses indicated change conflict explained significant proportion variance positive parenting scores negative parenting scores results suggest conflict significantly impacts parenting behaviors targeted parents course elsevier ltd rights reserved
ensuring safety efficiency operation challenging due complexity lifting operation real time lifting path planning system developed paper aims provide optimized collision free lifting path mobile operators first contribution developed system take advantage mounted sensors components hardware collect object information additional device needs secondly data storage path planning optimizing visualizing functions designed minimize required computer memory system installed applied mounted controller real time operation additional calculation capacity required system tested real construction sites demonstrated ability generate lifting paths satisfying operators expectation system independent software package installed mobile mounted necessary hardware
help task laboratory based measure designed simultaneously assess helpful behavior across five studies provide evidence establishes convergent discriminant validity help task cross sectional meta analytic evidence finds consistently significant associations helpful scores task prosocial aggressive personality traits experimental evidence reveals situational known induce aggressive prosocial behavior significantly influence helpful scores help task additionally motivation items studies indicate choices indeed associated intent helping discuss advantages limitations help task relative established measures helpful behavior wiley periodicals inc
seasonal affective disorder sad condition seasonal mood changes characterized recurrent depression autumn winter spontaneously spring summer evidence suggested circadian gene variants contribute pathogenesis sad study investigated polymorphisms clock genes relation seasonal variation healthy young adults seasonal variations assessed seasonality pattern assessment questionnaire prevalence sad winter type summer type significant difference found groups genotype distribution allele clock significantly frequent sad sad compared non odds ratio confidence interval global seasonality score significantly different among genotypes clock among genotypes however statistical difference observed body weight appetite subscales among genotypes body weight subscale among genotypes synergistic interaction clock seasonality knowledge study first reveal association clock gene seasonal variations mood behavior korean population although confirm previous findings association sad genes genes influence seasonal variations metabolic factors body weight appetite interaction clock genes contributes susceptibility sad
activity recognition fundamental many services pervasive computing ambient intelligence scenarios however delivering sufficiently robust activity recognition systems deployed confidence arbitrary real world setting remains outstanding challenge developments wireless inexpensive sensing devices enabled capture large data volumes upon variety machine learning techniques applied order facilitate interpretation inference upon data much documented research area main focused recognition across pre segmented sensor data approaches insufficient near real time analysis required many services ambient assisted living paper presents novel near real time sensor segmentation approach incorporates notions sensor time correlation
article novel expansion method successfully applied construct abundant travelling wave solutions equation aid symbolic computation equation one popular equation soliton physics appear many practical scenarios like thermal pulse wave propagation bound particle etc method reliable useful gives general exact travelling wave solutions existing methods solutions obtained form hyperbolic trigonometric rational functions including solitary singular periodic solutions many potential applications physical science engineering many solutions new already constructed additionally constraint conditions existence solutions also listed
objectives investigate urodynamic features women anterior vaginal wall compare degrees obtained urodynamic signs design prospective study setting ministry health training research hospital training research hospital subjects total intact women anterior vaginal wall evaluated stage graded according pelvic organ quantification divided three groups stage iii intervention full urodynamic test main outcome measure urodynamic parameters results established stage stage stage iii patients urine volume much stage iii compared stage respectively urodynamic first sensation fill first desire strong desire void less stage stage iii respectively maximum bladder capacity much stage iii stage conclusions study showed anterior vaginal wall together even stage also sensation bladder reduces increase stages anterior vaginal wall mask signs women large anterior wall weak detrusor contraction high urine volume
dehydrogenase last key enzyme putative ascorbic acid biosynthetic pathway higher plants evaluate effect gene manipulating accumulation cdna encoding acc isolated fruit known rich introduced tobacco plants agrobacterium mediated transformation constitutive promoter present study southern blotting revealed stable integration transgene single copy four independent transgenic lines among showed significantly enhanced transcript levels activities compared plants developed tobacco plant overexpressing exposed salt stress nacl transgenic lines found grow better increased shoot length fresh weight furthermore demonstrated highest accumulation fold higher expression level showed higher resistance oxidative stress caused compared results justify overexpression gene confers elevated accumulation tolerance environmental stresses
introduction hiv treatment guidelines recommend initiating antiretroviral therapy art regardless cell count barriers treatment estimated persons receiving hiv care prescribed art examined reasons gap care continuum methods surveyed probability sample hiv care providers returned surveys adjusted response rate estimated percentages providers followed guidelines characteristics art prescribing reason results providers initiated art regardless count providers less likely initiate patients adjusted prevalence ratios confidence interval practiced non white hiv aids program funded facilities reported pharmaceutical assistance programs provided insufficient medication meet patients needs never prescribing art patients among providers art cited patient reason cases reported adherence concerns mental health disorders substance abuse reported adherence concerns social problems factors cases art conclusions estimated hiv care providers adopted recommendations initiate art regardless count barriers treatment low volume providers non white hiv aids facilities less likely follow guideline among providers leading reasons art included patient adherence concerns
intrauterine contraception widely used highly effective reversible means birth control one potential disadvantage use intrauterine devices risk uterine process iud insertion possibility wall uterus health workers uterus due inadequate knowledge insufficient training paper discusses development smart iud insertion system used prevent uterine wall detecting specific distance wall safe release iud using sensor several prototypes developed prior final version iud results testing experiments conducted evaluate performance proposed device show sensor able detect distance also capable detecting distance target even high viscosity liquid developed prototype promises solution accurate iud insertion used training module health care providers helping remove fear using long lasting contraceptive method promote affordable modern contraceptive method society
background brain mitogen activated protein kinase mapk potential therapeutic target cognitive dysfunction based neuroinflammation synaptic dysfunction cycle pathophysiology progression offers innovative pharmacological strategy via inhibiting activated target neurons thereby enhancing possibility efficacy highly selective brain inhibitor attenuates cognitive dysfunction two distinct alzheimers disease relevant models avoids problems encountered previous mixed kinase inhibitor drug candidates therefore essential glial effects cns active kinase inhibitor addressed order anticipate future use clinical investigations methods explored effects glial biology relevant app knock mouse model previously showed efficacy suppression hippocampal dependent associative spatial memory deficits day administered daily month old mice days levels proinflammatory cytokines beta measured mouse cortex using elisa glial markers assessed immunohistochemistry microglia amyloid plaques quantified immunofluorescence staining followed confocal imaging levels soluble insoluble beta beta measured elisa studies vivo pharmacodynamic effects markers neuroinflammation complemented mechanistic studies murine microglia cell line using live cell imaging techniques monitor proliferation migration activities results intervention mice established therapeutic time window attenuated increased levels beta treatment also increased microglia within radius amyloid plaques without significantly affecting overall microglia plaque volume levels beta beta affected treatment significantly alter microglial migration proliferation cells conclusions results demonstrate efficacious dose selectively modulate responses associated pathology progression without pan suppression normal physiological functions microglia
article describes peoples daylight practical daily sun daylight based qualitative research project denmark article shows experience world sun daylight illustrates significance bodies lives describe taking approach present like plants people daylight order feel showing peoples engagement sun daylight phenomenon natural light becomes show people design daily life accordance sun sensation daylight normally taken acknowledged physiological element world shown sense people physiological origin daylight eye whose impact people lives best investigated socially studying daylight sensation practiced people everyday lives
study solutions one dimensional problem green theories two temperatures first existence uniqueness weakly regular solutions obtained second prove exponential stability green model non exponential stability model elsevier ltd rights reserved
negative affects violent threat hope setting limits potentials political agency article documents occupation body contingent explore capacities within affects violent drawing engaged providing political argue violent affects occupation form demonstrates agency political depression theoretically argue hand empirical account autonomy affect giving rise critical hope fear research presented therefore contributes addressing key question resistance beyond predominant affective register contemporary towards renewed political agency resistance
background established childhood maltreatment risk factor various mental substance use disorders date however little research focused possible long term physical consequences diabetes chronic disease association postulated methods based data sample men women canadian community health survey mental health study examines associations three types childhood physical abuse childhood sexual abuse csa childhood exposure intimate partner violence diabetes adulthood multiple logistic regression models used examine associations diabetes controlling effects socio demographic characteristics risk factors type diabetes results controlling socio demographic characteristics diabetes significantly associated reports severe frequent severe frequent csa dose response relationship observed occurrence csa considered strongest association diabetes observed severe frequent csa reported controlling type diabetes risk factors attenuated associations particularly significantly associated diabetes adulthood conclusion csa risk factors diabetes part associations diabetes mediated via risk factors type diabetes failure consider severity frequency abuse limit understanding importance risk factor diabetes
transforming growth factor beta tgf beta stimulates extracellular matrix production considered master regulator tissue fibrosis including idiopathic pulmonary fibrosis radiation induced fibrosis recent study identified dysregulated mir expression pulmonary fibrosis however role mir tgf beta induced pulmonary fibrosis remains unclear study demonstrated tgf beta mir expression human lung fibroblast cell lines mir inhibits pro activities tgf beta decreasing expression collagen type alpha alpha smooth muscle actin also identified transforming growth factor beta receptor direct target mir lung fibroblasts significantly decreased expression inhibited pro activities tgf beta expression mir insensitive construct restored induced tgf beta stimulation mir expressing cells therefore study suggests important role mir fibrotic lung diseases indicates mir potent therapeutic microrna treating pulmonary fibrosis
paper proposes decision making methodology using clustering methods fuzzy techniques determine optimal location distributed generation sources electrical distribution system based operational characteristics loss sensitivity factor voltage values nodes first found optimal distribution network partitioning using means clustering method used fuzzy techniques determine optimal location sources appropriate planning suggested method tested real rural distribution network nodes results demonstrate methodology successfully used determine optimal location electrical network without disrupting proper operation entire system
sustainability building projects become great concern construction professionals number different green building rating systems developed help ensure building projects designed built using strategies intended minimize eliminate impacts environment united states although leadership energy environmental design leed green building rating system widely accepted national standard sustainable building design assessment green buildings challenging time consuming owing complicated process green building rating process accelerated facilitated using computer technology building information modeling bim innovative new approach building design engineering construction management widely used architecture engineering construction industry enable green building rating building design bim applications building information represented way knowledge contained leed green building criteria extracted bim model support assessment paper building knowledge framework representing leed green building criteria presented proposed framework implemented bim platform obtain automated tool rating green building design development automated green building rating system results implementation discussed american society civil engineers
face increasing need discover knowledge data streams real time real time stream data mining needs compact data structure store transactions recent sliding window one scan efficient algorithm discover frequent compact data structure paper propose novel data mining algorithm called complete frequent real time transactions based sliding windows algorithm uses two data structures represents transactions sliding window one scan serves base tree algorithm efficiently maintains base tree adding new transactions removing old transactions without reconstruction phases novel data structure called group tree serves projection tree data item algorithm node base tree using top tree method build projection tree frequent low processing cost proposed algorithm therefore effective discovering frequent real time stream data performance evaluation experiments algorithms based show algorithm outperforms algorithms synthetic data set run time cost respectively also confirm proposed algorithm shows excellent results real world data sets elsevier inc rights reserved
ensure bridge safety functionality service conditions detecting local abnormalities long span bridge early stage always desirable challenging task stress influence lines derivatives recognized promising indices damage detection compared bridge global responses displacement acceleration stress strain conveniently measured often sensitive local damages paper explores novel damage localization approach synthesizing measurements multiple locations data fusion technique utilized compared measurement single sensor reliable damage related information improved sensitivity capability damage localization obtained synthesizing measured number sensors effectiveness proposed method validated numerical case study suspension bridge different hypothetical scenarios including single damage case double damage damage cases considered validation comparison damage detection results using single sensor data clearly indicates data fusion technique effectively enhance consistency information damage induced structural change minimize non consistent information noise effect multiple sensors installed close damage increasing number sensors benefits damage detection results excellent damage detection accuracy achieved different types bridge components properly selected monitoring therefore promising use proposed approach study damage localization real world long span bridges parametric studies conducted examine effects parameter noise levels approach
capacitor current feedback active damping extensively used grid connected converters filter however systems tends become unstable digital control delay taken account especially low switching frequencies paper discusses issue deriving discrete model digital control delay presenting stable region active damping loop high low switching frequencies order overcome disadvantage capacitor current feedback active damping paper proposes modified approach using grid current converter current feedback expand stable region provide sufficient active damping whether high low switching frequencies applying modified approach active damping loop simplified fourth order second order design grid current loop simplified modified approach work grid impedance varies active damping performance dynamic performance current loop verified simulations experimental results
paper present problem specific information based enhanced algorithm hybrid based optimization algorithm new algorithms tested virtual machine placement problem objective minimizing energy consumption integer space optimization problem algorithm relatively recent development swarm intelligence based explosion amplitude operator operates continuous space round function used convert explosion amplitude value nearest integer operate integer space algorithm design domain knowledge placement problem used spark generation explosion amplitude added information based selected components instead adding explosion amplitude instead components hybrid algorithm explosion amplitude operator algorithm migration operator algorithm user determined probability exploitation good candidate solutions placement problem hard existing results demonstrate evolutionary algorithms useful choice good quality solution reasonable computing resources experimentally compare performance hybrid first fit decreasing algorithms simulation results demonstrate two key findings study first algorithm consumes less cpu time compared algorithm second hybrid algorithms outperform algorithms terms average energy consumed
determining individual health status great importance better understanding life history trade offs growth reproduction maintenance however existing immunological methods invasive therefore suitable investigating health status wild populations thus urgent need non invasive methods assess immune status animals involved cell mediated pathway immune response type secreted activation monocytes macrophages investigated urinary serve biomarker health status first performed chemical validation commercial enzyme immune assay urine examined urinary levels increase acute period respiratory infections found levels reliably measured urine two species commercial stability experiments revealed considerable changes urinary levels relation multiple cycles extended exposure room temperature exposure sunlight led degradation urinary whereas sample storage two years affect urinary levels detectable diurnal variation levels levels remained stable across several days healthy individuals urinary levels independent sex individuals higher urinary levels adults importantly significant increase urinary levels period respiratory infection results demonstrate regular urine sample collection allow monitoring individual health status disease progression minimal disturbance subjects combination behavioral life history parameters method used investigate questions related life history trade offs
paper aims indicate relationships women work observation taking specific elements analysis texts photographs ads aforementioned publication annually years main objective modern progress city woven observations female work cited elements also suggested public mainly male conservative explain discourses around ideal women cases outside home work limits based assignments gender roles discusses text historical women issue one hand paradoxically visibility afforded enable analysis possible works women hence title article placed way fact issues
three month long acting new recently formulation characterised longest available dosing interval among long acting antipsychotics clinical profile month long acting recently european medicines agency public assessment report released april commentary main strengths limitations assessment report discussed order highlight possible implications clinical practice future research regulatory practices drug approval
background since turn century several epidemic outbreaks poultry diseases caused virus although multiple poultry derived strains isolated data exist comparative study origin evolution dissemination methodology parallel used investigate phenotypes derived isolates molecular biology bioinformatics methods employed investigate genetic characteristics evolution principal findings plaque diameter derived isolates larger derived isolates effect mammalian cells occurred rapidly induced derived isolates derived isolates furthermore derived isolates required less time reach maximum exhibited higher viral findings suggested poultry derived isolates invasive greater expansion capability derived isolates mammalian cells variations amino acid loci gene sequence revealed two mutated amino acid loci strains isolated malaysia thailand chinese compared prototypical strain virus furthermore isolates chinese six common variations gene loci differed southeast asian strains phylogenetic analysis indicated exhibit species barrier avian species consisted two lineages southeast asian chinese lineages molecular studies revealed recent common evolutionary appeared malaysia thailand province china represent three main sources related spread conclusions current broad distribution strains southeast asia chinese exhibited longer range diffusion larger scale propagation therefore addition china asian european countries linked asia used improved measures detect monitor related diseases prevent poultry elsevier rights reserved
teeth brittle highly susceptible cracking propose observations cracking used diagnostic tool predicting force inferring tooth function living fossil mammals laboratory tests model tooth structures extracted human teeth simulated identify principal fracture modes examination specimens reveals presence similar fractures wide range vertebrates suggesting cracks extended ingestion use fracture mechanics materials engineering provides relations quantifying critical forces terms characteristic tooth size thickness role microstructure determining cracks initiate propagate within beyond discussed picture emerges teeth damage tolerant structures full internal weaknesses defects yet able contain expansion seemingly cracks within findings impact dietary pressures forms study
background describes painful abnormal bony contact femoral neck left untreated contributes early osteoarthritis hip despite flat learning curve long operation times hip used increasingly often recent years surgery mini open technique offers possible alternative addresses abnormal morphological allows minimally invasive clearance hip motion still lack information influence greater degree soft tissue intrusion inherent mini open approach therefore decided evaluate medium term outcome mini open technique compare results technique reported literature patients material methods patients women men underwent mini open surgical treatment followed average months evaluation focused pre postoperative pain intensity numeric rating scale clinical functional outcomes range motion hip outcome score modified hip score changes athletic behaviour satisfaction patients radiological analysis angle anterior head neck offset head neck offset ratio ossification grade performed using preoperative immediate postoperative follow radiographs finally results compared reported technique literature results average pain level decreased confirmed postoperative pain free period months months still almost pain free time final increased experience insufficient gains surgery surgeons apply technique circumstances
widely used hair skin care products high concentrations cooling towers paper industry product recognized potent contact allergen discharged wastewater treatment plants industrial processes domestic however role biological treatment characterized therefore effect composition performance activated sludge analyzed purpose sequential batch reactor fed synthetic solution containing addition shown significant effect organic matter dissolved organic carbon removal remained constant contrary loss efficiency process occurred ammonium removal decreased per cycle throughout experiment first affecting nitrite bacteria around cycles also ammonium bacteria disappeared shown fluorescence situ hybridization analysis studies based counts sludge biotic index indicated end process stable community obtained finally tests indicated bacteria shown shorter lag periods sludge previously fed role biological treatment characterized increase knowledge pollutant effects activated sludge improve performance
utilizing qualitative data focus groups adolescent girls participating summer program mean age study examines following research questions adolescent girls perceive field promising practices engage girls education guided ecological social role theories findings reveal single sex collaborative settings encouraging supportive teachers female practices contribute girls increased interest field findings also suggest emphasis creative collaborative problem solving processes real world application inherent likely increase girls engagement field results implications educators researchers policy makers aiming close gender gaps field computer science build interest area critical national need
year creation network consisting decentralized database storing transactions whose quantity predetermined protocol independent authority aim article describe limits use medium exchange network operation carried high costs electrical energy consumption time reflected price transactions low transaction prices one main arguments promoters possible continuous new circulation prove work demanding method currently existing methods securing mechanism reduces rewards create pressure decrease hash rate reflection rate network security pressure decrease hash rate now increasing efficiency mining devices future therefore probably bring fundamental questions mean network real costs running network reflected costs transaction network able compete whose operation carried much lower cost mechanism ultimately cause declined hash rate thereby also reduction network security
consider tree nodes weight drawn article study problem supporting various path queries tree path counting query number nodes query path whose weights query range path reporting query requires report nodes path median query median weight path two given nodes path selection query returns smallest weight design data structures encode using sigma bits space support path counting queries sigma time path reporting queries sigma time path median path selection queries sigma sigma time entropy weights nodes size output results greatly improve best known data structures also match lower bounds path counting median selection queries sigma omega
beliefs surrounding practice eating animals widely held argued constitute ideology named developed validated novel inventory measure two positively related components beliefs defense anticipated defense legitimate practice eating animals support killing animals meat inventory showed hypothesized two dimensional structure good internal stability study also demonstrated convergent discriminant validity inventory study expected defense predicted meat consumption significant predictor animal study scales significantly related beliefs including right wing social dominance orientation related symbolic racism study taken together findings highlight utility two dimensional conceptualization measurement beliefs offer new insights one common human behaviors eating animals behavior widely believed also ideological one elsevier ltd rights reserved
internal combustion engines applied energy converters passenger cars order increase efficiency energy integration techniques used recover waste heat adapted methodology required design organic rankine cycle waste heat recovery technology test influence external temperature efficiency idea cluster external temperature profile typical external temperature multi periods energy system design tested typical multi periods article methodology applied vehicle diesel engine order define energy integrated configuration vehicle estimate cost additional equipment performance indicators energy integration technology internal combustion engine done discussed according multi periods energy recovery potential single stage diesel engine assessed different temperature profiles equipment simultaneously pre sized cost estimated
effective theory based intervention strategy developed improve worker adoption dust control tool reduces dust exposure prevention design adoption readiness model arm employed develop educational materials hands training cues action educational materials targeted improve worker knowledge health risks associated construction hands training developed objective improving worker self efficacy regarding new equipment additionally cues action given workers cues hard pretest posttest experimental design control group questionnaire data analyzed using independent tests gain scores significant changes seen worker self efficacy trust technology overall readiness adopt tool theory based intervention strategies found effective improving worker willingness use tools intervention methods include training regarding risks worker health hands training tools cues action use tools
paper addresses investigation hydrodynamic behavior new type cap called cap computational fluid dynamics model developed predict hydrodynamics operated spray regime model considers two phase flow gas liquid like code framework homogeneous multiple size group model model shear stress transport turbulence model implemented detailed insights hydrodynamic behavior inside obtained relation velocity pressure cross section area flow inside cone also formulated computational fluid dynamic cfd results show pressure variation forces liquid highly turbulent leads interface break effect different heights also studied cfd simulations results show height significant role hydrodynamics especially uniform gas distribution reducing rates
changes levels expression melting fruits studied gene analysed identify polymorphisms early marker assisted selection texture role assessed western northern blotting biochemical analyses polymorphisms gene revealed reverse transcription polymerase chain reaction pcr sequencing protein detected fruits levels protein higher increased fruits remained lower constant fruits different levels appeared caused differential expression gene whose open reading frame orf showed five single nucleotide polymorphisms snps compared one snps allowed determine allelic configuration melting locus also seemed early mas phenotypes phenotype seem caused large deletion gene
main objective paper evaluate feasibility performance building materials similar gas concrete using oil eco fly ash natural clay natural study eco wastes produced turkey thermal power station used producing building material used raw materials producing samples eco used binding density thermal conductivity compressive tensile strength decreased increase eco levels moreover increasing process temperatures decreased density thermal conductivity compressive tensile strength loss water absorption increased increase eco ratios process temperatures
background sudden death syndrome describes sudden death negative autopsy toxicological analysis cardiac genetic disease likely etiology objectives study investigated clinical utility combined yield post mortem genetic testing molecular autopsy cases comprehensive clinical evaluation relatives methods evaluated validated cases suitable dna median age years males underwent next generation sequencing using extended panel primary electrical disorder cardiomyopathy genes pathogenic likely pathogenic variants classified using american college medical genetics consensus guidelines yield combined molecular autopsy clinical evaluation families evaluated gene level rare variant association analysis conducted cases versus controls results clinically pathogenic likely pathogenic variant identified cases main etiologies established polymorphic ventricular long syndrome respectively gene based rare variants association analysis showed enrichment rare predicted deleterious variants combining molecular autopsy clinical evaluation families increased diagnostic yield conclusions molecular autopsy electrical disorder cardiomyopathy genes using guidelines variant classification identified modest realistic yield data highlighted predominant role polymorphic ventricular long syndrome especially gene minimal yield genes furthermore showed enhanced utility combined clinical genetic evaluation authors published elsevier behalf american college cardiology foundation
hereditary angioedema hae rare autosomal dominant disorder caused mutations factor genes potentially fatal particularly identified early stage apart androgens children pregnant women range effective albeit expensive treatments recently become available hae patients cost new treatments beyond reach developing countries time cure disorder spite mutations gene autoimmunity infections prominent features condition present argument hae viewed primarily metabolic liver disorder conceptual paradigm shift stimulate basic research facilitate new therapeutic approaches hae outlined paper suggest several novel potential treatment options hae perspectives clinical immunology molecular biology liver transplantation many offer prospect disorder effectiveness options rapidly improving many cases risks decreasing given high costs treating hae curative options become feasible next decade
subject paper detection mitigation data injection attacks randomized average consensus algorithms broadly known main advantages randomized average consensus fault tolerance distributed nature unfortunately flat architecture algorithm also increases attack surface data injection attack even though cast problem context sensor network security attack scenario identical existing models opinion dynamics called model agents steering opinions group toward final state average network initial states specifically propose two novel strategies detecting locating attackers study detection localization performance numerically analytically detection localization methods completely decentralized therefore nodes directly act conclusions stop receiving information nodes identified attackers show simulation network often recover fashion leveraging resilience randomized reduced network connectivity
canine respiratory diseases commonly seen dogs along infections multiple respiratory pathogens including viruses bacteria virus infections even dogs also reported clinical signs caused different respiratory etiological agents similar makes differential diagnosis imperative oligonucleotide microarray system developed study wild type vaccine strains canine virus influenza virus canine detected differentiated simultaneously microarray chip detection limit copy numbers influenza virus respectively clinical test results nasal samples showed microarray remarkably better efficacy multiplex pcr gel method positive detection rate microarray gel among samples respectively vaccine strain pathogen infections demonstrated microarray multiplex pcr gel oligonucleotide microarray provides highly efficient diagnosis alternative applied clinical usage greatly assisting disease therapy control elsevier rights reserved
medical additive manufacturing requires standard language models models commonly derived computed tomography images using threshold selection performed manually automatically aim study assess impact manual default threshold selection reliability accuracy skull models using different technologies one female one male human head using multi detector row dual energy two cone beam four medical engineers manually bony structures images lowest highest selected mean threshold values default threshold value used generate skull models geometric variations manually models calculated furthermore order calculate accuracy manually default models models optical scan dry female male gold standard intra inter observer variability manual threshold selection good intra class correlation coefficients engineers selected grey values closer soft tissue compensate bone geometric variations manually models multi detector row dual energy cone beam models demonstrated ranging multi detector row dual energy cone beam study demonstrates manual threshold selection results better models default use dual energy cone beam technology present form deliver reliable accurate models medical additive manufacturing new approaches required based pattern recognition machine learning algorithms
power electronics pulse width modulation pwm inverter one families electrical circuits converts electrical supply one level another using semiconductor based electronic switches important characteristic types circuits switches operated one two states continuous conduction operations transitions cause switching power losses lead power loss pwm inverter purpose switch assist process transferring power source load power losses affect performance efficiency load overcome problems paper asymmetric space vector pulse width modulation technique proposed proposed additional voltage sectors switching states determined state transition matrix subsequently using proposed technique speed induction motor controlled error speed change error speed calculated using fuzzy logic controller output applied inverter stability improved switching loss harmonics effect proposed inverter analyzed
gold nanoparticle probe based assay developed detection hepatitis virus hcv core antigen anti hcv core antigen polyclonal antibodies single stranded signal dna labeled gold nanoparticle probe dna enzyme used degrade anti hcv core antigen monoclonal antibodies coated magnetic probe mmp hcv core antigen mmp sandwich formed target antigen protein added captured separated immuno complex containing single stranded signal dna characterized probe based real time fluorescence pcr detection limit determined hcv core antigen magnitude greater elisa coefficients variation intra assay inter assay respectively ranged improved decreased interference new way hcv core antigen detection published elsevier
objective evaluate prevalence systemic localized infection candida species possible association demographic clinical laboratory manifestations therapy patients rheumatic diseases taking tnf blockers methods consecutive patients rheumatic diseases receiving anti tnf agents included following risk factors four weeks prior study analyzed use antibiotics drugs hospitalization invasive procedures subjects evaluated clinical complaints specific blood cultures obtained fungi blood samples collected candida spp detection polymerase chain reaction results patients rheumatoid arthritis ankylosing spondylitis juvenile idiopathic arthritis psoriatic arthritis conditions included average age patients years male mean disease duration years sixty four patients receiving adalimumab etanercept infliximab eighty one percent patients concomitantly taking drugs time study one patient localized fungal infection vaginal none patients included systemic positive blood cultures fungi positive candida spp peripheral blood sample conclusions first study assess prevalence invasive localized fungal disease candida significant number patients rheumatic diseases anti tnf therapy demonstrated low risk despite high prevalence immunosuppressive drug use elsevier
physical emotional sexual child abuse major problems south africa study investigates whether children know post abuse services disclose seek services outcomes help seeking behaviour examines factors associated request receipt services self report questionnaires completed adolescents aged south africa prevalence frequent weekly physical abuse frequent emotional abuse lifetime contact sexual abuse name one suitable formal service abuse disclosure abuse victims disclosed received help common caregivers teachers abuse victims receive help due non disclosure inactivity services received help formal health social services community action emotional abuse sexual abuse female gender associated higher odds help seeking children south africa showed high knowledge available services access receipt formal services among abused children low notably fewer children received help formal services community action urgent action needed improve service access child abuse victims
single semester molecular biology laboratory developed students design execute project examining transcriptional regulation saccharomyces cerevisiae three weeks planning allocated developing hypothesis literature searches use bioinformatics common experimental plans address cell process three genes encode proteins involved process regulated response changing environmental conditions planning includes designing amplify putative promoters three genes interest pcr product cloned proximal yeast reporter plasmid techniques used include electrophoresis extraction dna plasmid purification bacteria restriction digestion ligation bacterial transformation promoter reporter plasmid transformed yeast transformed yeast cultured conditions prescribed experimental design beta activity measured course provides independent research experience group setting maintained line regular feedback projects presentation worth grade last three years students met expectations experimental design data acquisition analysis international union biochemistry molecular biology
inhibitors first line therapy erectile dysfunction constant discoveries nitric oxide cyclic cell signaling pathway smooth muscle control tracts make promising pharmacologic agents benign diseases article reviews literature contains previously data activities inhibitors treating disorders scientific discoveries improved understanding cell signaling pathway mediated relaxation moreover clinical applications widely recognized demand efficacious cases daily dosing combination testosterone recommended refractory cases soluble also promising role management severe conditions also first rehabilitation strategy prostate cancer patients especially combined antagonists effective benign prostatic hyperplasia except maximum urinary flow rate max recently proved without furthermore currently various phases clinical preclinical researches promising potential urinary genital illnesses premature urinary tract overactive bladder disease female sexual dysfunction inhibition expected effective strategy treating benign diseases however clinical studies basic researches investigating mechanisms disorders required
machine learning approaches widely used identification neuroimaging data however approaches require large samples suffer challenges associated multi site multi protocol data propose novel approach address challenges demonstrate usefulness autism brain imaging data exchange database predict symptom severity based cortical thickness measurements individuals autism spectrum disorder asd four different sites proposed approach consists two main stages domain adaptation stage using partial least squares regression maximize consistency imaging data across sites learning stage combining support vector regression regional prediction severity elastic net linear regression integrating regional predictions whole brain severity prediction proposed method performed markedly better simpler alternatives better multi site single site data resulted considerably higher cross validated correlation score previously reported literature multi site data demonstration utility proposed approach detecting structural brain abnormalities asd multi site multi protocol dataset indicates potential designing machine learning methods meet challenges data
goal present study examine contributions associative strength similarity terms shared features production false memories deese roediger mcdermott list learning paradigm whereas activation monitoring account suggests false memories driven automatic associative activation list items lures combined errors source monitoring accounts fuzzy trace theory global matching models emphasize importance semantic level similarity thus predict shared features list items increase false memory participants studied lists nine items related half lists consisted items associated share features half included items equally associated also shared features many cases related items two types lists carefully matched terms variety semantic factors lures used across list types two experiments false recognition critical lures greater following study lists shared features critical suggesting similarity categorical taxonomic level contributes false memory beyond associative strength refer phenomenon feature boost reflects additive effects shared meaning association strength generally consistent accounts false memory emphasized thematic feature level similarity among studied representations
article analyses public responses china performance programme international student assessment based data obtained media accounts materials published research findings show responses china generally reflective measured self critical drawing upon notions tradition horizon prejudice paper responses reflect prevailing china perceive education system rigorous exam oriented argued knowledge structures china shape chinese interpretations assessment format leading success study introduces eyes highlights mediating effects local eyes policy actors era global educational governance
therapy patients suffering psychiatric disorder schizophrenia requires usage antipsychotic drugs classified two different groups first generation second generation antipsychotics study compares effects two synapse formation synaptic activity embryonic rat hippocampal neurons end development nets formation synapses resulting spontaneous network activity control treatment conditions studied using indirect culture system neurons astrocytes completely defined media number extent consist extracellular matrix surrounding synapses altered hippocampal neurons exposure antipsychotic drugs contrast treatment hippocampal neurons led slight decrease whereas induced significant increase number structural synapses days differential effect concerning synapse numbers also reflected spontaneous activity neuronal networks monitored arrays context application reduced significantly enhanced network activity unexpectedly regarded caused similar effects augmented synapse number network activity pilot study provides proof concept neuron culture model used investigate impact antipsychotics pivotal parameters neuronal cell biology thereby support comparative analysis antipsychotics applied therapy schizophrenia ibro published elsevier ltd rights reserved
purpose study elderly peoples values preferences end life care yet known details aim present study investigate end life decision making among japanese elderly people required home care services study designed qualitative research strategies using face face interview data recorded nursing care records focus advance care planning design methods total elderly people males females home care support offices participated results implications finally extracted following themes anxiety future control current daily life mutual support decision making elderly people living home generally feel anxious future seemed try avoid thinking seriously possible complications life also tend leave end life decision someone decisions tend change advance age condition findings suggest medical professionals care managers always support patients decisions allowing views informal caregivers elderly people rely decision making elsevier rights reserved
state hospital engagement network collaboration hospital system established goal reducing hospital acquired pressure ulcers month unfavorable trend nurse sensitive clinical indicators called immediate process improvement retrospective chart review resulted identification predominant risk factors placing burn patient high risk pressure formation implementations pressure prevention measures inconsistent nurses demonstrated varied levels knowledge products used prevention became imperative examine processes within unit provide nursing education access skin care supplies advanced skin wound care products maintaining skin integrity creation evidence based guidelines necessary improve patient outcomes collaborative team approach influenced nursing physician awareness pressure risk evidence based prevention guidelines developed consistency early intervention achieved supporting culture safety change collaborative practice positive trend pressure incidence data supports success program
coordinated access care homeless people program brief multidisciplinary case management intervention homeless adults discharged hospital canada describe rationale program development details mixed methods evaluation underway characteristics service users funded local health authority aimed improve access continuity care health service use outcomes homeless adults discharged hospital assess feasibility acceptability impact program mixed methods case study undertaken total program users enrolled study completed quantitative survey measures program entry assess key health social outcomes using pre post cohort study design follow assessments took place months study entry participants male white canadian born single never married average age years nearly participants least one emergency department visit past months half indicated least three chronic health conditions indicated least three mental health diagnoses addition qualitative data collected evaluate experiences continuity care challenges care transitions population using depth interviews sample service users managers organizations focus groups staff service providers people lived experience improving health health service use outcomes among homeless adults chronic health conditions key priorities many future findings inform service delivery homeless adults discharged hospital exposing factors associated positive program outcomes barriers facilitators continuity care disadvantaged population
aim explore microrna mirna expression renal clear cell carcinoma methods compared mirna expression profiles pairs adjacent tissue patients using mammalian mirna microarray containing whole human mature precursor mirna sequences verify microarray results northern blotting carried randomly selected mirnas results totally mirnas identified valid expression samples specifically detected samples detected downregulated compared sample upregulated without significant difference mirnas tissues exhibit overall higher expression level tissue chip results confirmed northern blot analysis conclusion study help clarify molecular mechanisms involved pathogenesis mirnas potentially serve novel diagnostic biomarker crown copyright published elsevier ltd rights reserved
background patients major depressive disorder mdd present heterogeneous clinical symptoms childhood abuse associated psychopathology aim study identify structural brain abnormalities mdd assess differences gray matter density associated childhood abuse mdd methods differences regional mdd patients healthy controls assessed using magnetic resonance imaging optimized voxel based morphometry within mdd group comparisons performed focusing experience maltreatment childhood mdd child abuse mdd without child abuse results compared healthy controls mdd patient group showed decreased bilateral orbitofrontal cortices right superior frontal gyrus right posterior cingulate gyrus bilateral middle occipital left addition patient group showed increased bilateral occipital cortices left cerebellar within mdd patient group subgroup abuse showed tendency decreased right orbitofrontal cortex showed increased left gyrus compared subgroup without abuse conclusions findings suggest complicated dysfunction networks cortical subcortical circuits mdd addition increased gyrus possible reduction orbitofrontal cortex mdd patients abuse subgroup associated abnormalities body perception emotional dysregulation
advent new technologies various services provided context computer networks large volume data generated main challenge area providing network protection services various threats vulnerabilities far many techniques proposed deal threats techniques pursue goal preventing attackers reaching objectives solution based early warning system exactly security teams need manage threats properly complement intrusion detection system proactive approach security threats carried early detection potential behavior system evaluating scope malicious behavior finally using suitable response kind detectable security event paper presents comprehensive review including definitions applications architectures alert correlation aspects technical requirements furthermore previous studies existing described analyzed classification presented commercial systems systems research development finally studies conclude challenges research issues still remain open copyright john wiley sons ltd
purpose determine exposure young adolescents extremely violent movies design cross sectional school based survey middle school students randomly selected new middle schools survey contained unique list movies randomly selected top box office determined content analysis contain extremely violent material movie listed adolescents asked indicate ones seen movie appeared approximately surveys calculated percentage students seen movie representative subsample student population also examined characteristics associated seeing least one extremely violent movie complete survey information obtained students sample primarily white equally distributed gender results average extremely violent movies seen students sample range popular movie seen two thirds students overall fifth movies violent content seen many adolescents examples include rated graphic images related sexual violence including scene sexuality natural born rated extreme violence graphic images language sexuality seen respectively older students males lower socioeconomic status poorer school performance significantly likely seen least one extremely violent movie conclusion study documents widespread exposure young adolescents movies often violence given many films better marketing practices film industry warranted society adolescent medicine
introduction common humoral immunodeficiency iga deficiency one first papers addressing cellular molecular mechanisms underlying iga deficiency indicated immature iga positive lymphocytes present patients suggests genetic background iga still intact class switching take place moment ruled genetic environmental factors covered clinical presentation biological functions iga management iga deficiency reviewed iga deficient patients relationship loss function mutation transmembrane activator calcium modulating ligand interaction gene found many genes also associated gut microbiota important environmental trigger iga commentary expression iga deficiency due genetic environmental factors role gut microbiota excluded
proliferation application specific use heterogeneous clusters rapidly increasing consisting processors different architectures heterogeneous cluster aims providing different performance cost different types workloads order achieve peak performance software running heterogeneous cluster needs designed carefully provide enough flexibility explore variety propose design methodology complex software applications data dependencies software application designed way flexibility different hardware platforms facilitate resource management features high scalability parallelism using application case study present concept discuss management scheduling communication modules also present experimental results demonstrating improvements effects system scaling throughput
obesity rates continue rise effective prevention treatment programs urgently required obesity requires weight management programs accessible scalable large numbers people growing evidence commercial programs combine behavior change techniques key changing habits effective first line helping people adopt healthier dietary activity patterns particular digital programs potential provide service large numbers people widely accessible cost effective individual however date digital programs relatively utilized evaluated little published evidence performance programs large scale outside partnerships primary care participants self refer pay nominal fee purpose following study examine interrelated effect motivation opportunity ability behavioral outcomes digital commercial weight management program address aim thematic content analysis participants qualitative responses habits learned changes adopted conducted findings reveal habits learned changes adopted result participating program influence weight loss outcomes health outcomes
reservoir play important role hydrocarbon recovery mechanism process reservoir analysis concerned simultaneous study fluid flow mechanical response reservoir injection accurate prediction effects injection assist modeling carbon dioxide recovery process making better design process production equipment paper deals implementation program interface code developed couple conventional reservoir simulators using partial coupling algorithm reservoir partially coupled approach presented allows iteratively take impact account fluid flow calculations therefore performs better prediction process proposed approach illustrated realistic field case reservoir coupled models show case lower maximum bottom hole injection pressure cumulative oil production scenarios moreover high injection pressures production rates change injection bottom hole pressure variations also fem analysis reservoir showed injection pressure psi plastic strain occurred parts reservoir related stress path show critical behavior
muscle injuries frequently occur sport one commonest injuries diagnosis treatment muscle injuries impose high demands medical treatment order ensure successful regeneration rapid return sport injuries treated skeletal muscles high endogenous capacity repair regeneration conservative treatment includes initial field therapy known rice principle common recommended initial treatment sports injuries primary therapy target reduce pain swelling bleeding thus limit initial inflammatory process prevent damage first days injury brief immobilization helps reduce injury rate formation tissue many possible additional treatments including injections manipulation joint rehabilitation programs including stretching strengthening acute treatment phase complete days active treatment including trunk stretching strengthening started gradually despite high prevalence studies treatment management injuries aim manuscript review literature classification treatment strategies muscle injuries
core components signaling pathway cascade kinases govern phosphorylation downstream transcriptional namely yes associated protein domain containing transcription regulator protein also known signaling pathway considered important tumor suppressor pathway dysregulation noted variety human cancers enable cancerous cells overcome contact inhibition grow spread interestingly however recent studies somewhat different perhaps intriguing story studies found function central hub integrates signals multiple upstream signaling pathways cell cell interactions mechanical forces bind activate different downstream transcriptional factors direct cell social behavior cell cell interactions review present latest findings role skin physiology pathology tumorigenesis discuss newly developed therapeutic interventions target human cancers prospects use skin cancer treatments elsevier rights reserved
need understand sustainable solutions persistent energy energy nigeria even face abundant renewable fossil energy resources motivated study study justified solar energy highest priority energy source nigeria globally detailed review past current future status solar integration nigeria presented seen grid connected solar power integration past status current status future status completely number understanding signed existing supportive solar energy policies highlighted nigeria policy landscape near zero status solar integration poor implementation existing provisions government recommendations made basis existing policies proposed policies additional provisions existing laws federation accommodate support solar energy integration suggested recommended poor status solar integration nigeria viewed positive light potential foreign status guarantee solar power thermal industry first hand investment opportunity
telomere shortening reported related oxidative stress associated aging process aging associated diseases including alzheimers disease measured methylated non methylated telomere lengths peripheral blood mononuclear cells patients healthy controls southern blotting analysis using methylation sensitive insensitive restriction enzyme patients normal mean telomere lengths unchanged distribution telomere length peripheral leukocytes however shortest telomeres relatively methylated patients genders compared age matched controls observed pathogenesis associated epigenetic condition overall telomere length distribution relative elevation methylation short telomeres peripheral blood leukocytes characteristic implies leukocytes containing short telomeres less methylated tend removed faster peripheral blood patients
magnetorheological fluids based electro magneto responsive particles respectively smart suspensions ability undergo phase transitions liquid like solid like state result stimuli electric magnetic field application polymer composite materials rather pure polymeric inorganic materials aiming solve problems use materials low activity physical chemical stability production cost various fabrication methods polymer composite materials electro activity magneto activity developed effectively applied field boost wide fluids briefly reviewed perspective society chemical industry
aim study improve hybrid dual ester phosphate composites via sequential thermal polymerization high performance applications aerospace electronic devices novel ester group containing ester synthesized characterized silicon containing compound compound phosphate cured using ultraviolet thermal methods using system ester formulations normally prepared high temperatures prepared room temperature study maintains ease application esters thermal stability thermal conductivity samples evaluated thermogravimetric analysis tga differential scanning calorimetry dsc limiting oxygen index laser flash method respectively samples characterized following analysis gel content water absorption capacity stress strain test samples determined contact angle measurements moreover surface morphology samples investigated scanning electron microscopy sem eds obtained results prove composites good thermal mechanical properties help easier preparation techniques used many applications aerospace electronic devices materials engineering elsevier rights reserved
objective depression screening increased prevailing knowledge medication associated mental health risk highest depression screening primary care practices medications mental health risk prescribed estimated considering absence presence clinical decision support systems materials methods cross sectional descriptive study using national ambulatory medical care survey data conducted primary care physician visits classified based whether medication prescribed severe warning moderate warning adverse event documented mental health risk adjusted odds depression screening risk warning level estimated controlling important sociodemographic factors presence computerized systems medication guideline recommendations results depression screening primary care practice visits medications prescribed increased higher medications moderate severe mental health risk warning medication disease depression screening increased visits least one medication prescribed aor severe warning aor moderate warning aor mental health risk mental health adverse event alone aor discussion depression screening increased medications prescribed documented mental health risk presence clinical decision support systems help minor major medication associated mental health risks conclusions appropriately positioned warning systems targeted content workflow health information exchange improve depression screening risk patients elsevier inc rights reserved
background testosterone deficiency patients heart failure associated decreased exercise capacity mortality however impact hospital rate uncertain furthermore relationship testosterone deficiency sympathetic activation unknown objective investigated role testosterone level hospital mortality rates sympathetic nerve activity patients methods total testosterone free testosterone measured hospitalized male patients left ventricular ejection fraction new york heart association classification patients placed low testosterone normal testosterone groups hypogonadism defined muscle sympathetic nerve activity recorded subpopulation patients results length hospital stay longer group compared group days similarly cumulative hazard within year greater group compared group single predictor analysis hazard ratio confidence interval predicted hospital within days addition within days predicted increased mortality activation estimated significantly higher group compared group heart conclusion results support concept independent risk factor hospital within days increased mortality patients furthermore increased observed patients
headache one common neurological symptoms reported childhood adolescence leading high levels school learning problems poor psychiatric conditions pediatric headache associated several neurological psychiatric comorbidities particular depression anxiety disorders sleep disorders epilepsy associated pediatric migraine goal article review comorbidities associated pediatric headache thereby enabling pediatric identify shared triggers develop synergistic management strategies address headache comorbidities
adolescents spend significant part leisure time watching programs movies violence unknown however extent violent media use severity aggression displayed affect adolescents brain function investigated skin conductance responses brain activation functional brain connectivity media violence healthy adolescents event related functional magnetic resonance imaging experiment subjects repeatedly viewed videos displayed different degrees aggressive behavior found downward linear adaptation skin conductance responses increasing aggression desensitization towards aggressive videos results revealed adaptation parietal network including left lateral orbitofrontal cortex right precuneus bilateral inferior parietal showing downward linear adaptations desensitization towards aggressive videos causality mapping analyses revealed attenuation left indicating activation viewing aggressive media driven input parietal regions decreased time aggressive videos conclude aggressive media activates emotion attention network capability emotional responses reduced attention repeated viewing aggressive media contents restrict linking consequences aggression emotional response therefore potentially promotes aggressive attitudes behavior
interacting rnas small non coding rnas reported mostly germ line cells cancer cells however presence liver yet reported previous study micrornas liver detected small rnas sequenced technology total predicted found liver selected high significantly differential expression normal regenerative liver tissues subsequent verification northern blotting ten identified six matched known actual expression six known four novel validated qrt pcr addition total target genes predicted pathway function analyses five annotated eighteen annotations results indicated identified involved many important biological responses including immune inflammation cell specific differentiation development angiogenesis manuscript provides first identification liver using technology elucidation regulatory role liver findings provide useful resource facilitate development therapeutic strategies liver damage elsevier rights reserved
background objectives multidimensional personality construct including components difficulties identifying feelings difficulties describing feelings externally oriented thinking different features thought reflect specific deficits cognitive processing regulation emotions aim present study examine first time patterns deployment attention function components healthy persons using eye tracking technology assumed linked avoidance negative images methods healthy adults viewed freely pictures consisting anxiety related depression related positive neutral images gaze behavior registered assessed item scale measures anxiety depression visual perceptual intelligence also administered results main effect emotion condition times observed viewing time lowest neutral images longer depression related happy images longest anxiety related images gender significant effects times correlated negatively time depression related anxiety related images correlations times depression trait anxiety intelligence limitations assessed exclusively self report conclusions results show influences attention deployment simultaneously presented emotional pictures reduce attention allocation information attentional characteristic individuals mood protecting effects also detrimental impacts social relationships coping competencies elsevier ltd rights reserved
behaviors involving interaction multiple individuals complex frequently crucial animals survival interactions ranging across sensory modalities length scales time scales often subtle difficult characterize contextual effects frequency behaviors become even difficult quantify physical interaction animals conventional data analysis due visual occlusion introduce method quantifying behavior fruit fly interaction combines high throughput video acquisition tracking individuals recent unsupervised methods capturing animals entire behavioral repertoire find behavioral differences solitary paired individual opposite sex identifying specific behaviors affected social spatial context pipeline allows comprehensive description interaction two individuals using unsupervised machine learning methods used answer questions depth complexity variance fruit fly
induced positive past experience counteract promote prosocial behavior however process thinking experience quite different effects experiences rarely people motivated time tendency experiences situations participants encounter later thus increasing consumer effect emerge however consumers aware waiting beneficial attainment benefit moreover relationship consumer diminished people perceive experience memory experience rather eight studies confirmed effects processes underlie
stimulating agents commonly used treat anemia myelofibrosis information predictors response limited therapy analyzed patients severe anemia inadequate levels treatment start revised criteria international working group myelofibrosis treatment research anemia response achieved patients median response duration multivariate analysis baseline factors associated higher response rate female sex leukocyte count serum patients features significantly higher response rate respectively patient years follow treatment nine patients developed thrombotic complications six arterial three venous accounting events per patient years survival time start longer anemia responders non responders already established predictive value levels data help identify patients likely benefit treatment
paper investigates impact related permanent magnets torque performance machines usually show considerable sensitivity regarding geometric dimensions material characteristics consistent approach presented order minimize computational effort evaluating sensitivity robustness reliability thereby design experiments used minimize required number finite element simulations work box based approach considered subsequently surrogate modeling technique based second order equation applied consequence reduction computational cost achieved obtained results compared outcomes solely derived means finite element computations good agreement observed illustrated providing probability distribution torque considered machine design addition cumulative distribution presented usually applied analyzing reliability considering analysis impact part optimization scenarios increases number designs analyzed least one degree magnitude obtained results look promising achieving feasible computational cost
frequency domain approach design digital feedback controls systems presented noise gain minimized subject phase margin constraint controller expressed repeated pole expansion reduces optimization quadratic problem linear system equations pid filter controls produced limiting case
oral direct inhibitor approved international regulatory agencies stroke prevention patients paroxysmal persistent non rheumatic atrial fibrillation benefits widely described use geriatric population without risk chronic kidney disease common comorbidity thus frequent renal function elderly patients recommended report case elderly man affected heart failure worsening renal function developed acute hepatitis successfully treated continuous venous although therapy suggested strategy acute bleeding approach useful related life threatening conditions described report
patients diagnosis schizophrenia display social cognitive deficits however little known patients nonverbal communication social encounters others review identified studies investigating nonverbal communication patients face face interactions addressing nonverbal differences patients others nonverbal behavior patients partners association nonverbal behavior symptoms association nonverbal behavior social outcomes patients displayed fewer nonverbal behaviors interaction negative symptoms pattern positive symptoms associated heightened nonverbal behavior patients partners changed nonverbal behavior response patient reduced prosocial behaviors interaction associated poorer social outcomes evidence suggests patients nonverbal behavior face face interaction influenced patients symptoms impacts success social interactions
controlling microbial activity primary concern management large volumes wastewater produced water generated high volume hydraulic study analyzed transcriptional activity three produced water samples goal study describe active metabolic pathways industrial concern produced water management reuse improve understanding produced water microbial activity analysis revealed active biofilm formation production stress management mechanisms produced water microbial communities biofilm formation sulfate reduction pathways identified samples genes related diverse array stress response mechanisms also identified implications efficacy additionally active expression pathway identified sample produced water collected prior holding pond storage active microbial community identified analysis markedly different community composition identified rrna sequencing highlighting value evaluating active microbial fraction assessments produced water potential evaluation application strategies results indicate microbial processes active produced water taken consideration designing produced water reuse strategies
paper examines expressions experiences sexual stigma respect definitions masculinity identity conflicts thematic analysis life history narratives self identified gay men living turkey analysis reveals sexual prejudice emerges widely accepted masculinity ideology gay participants narratives indicate construction masculinity vigorous process established via encounters masculinity findings discussed context relevant literature relation turkish cultures traditional understanding gender gender roles
secure summation one applicable functions secure computation mpc group users computes summation value private inputs current solutions problem basically adding random number private inputs splitting inputs among users need secure channel among members moreover resistant players impose high communication cost paper propose three cryptography based protocols secure sum need secure channel secure players also communication cost proposed protocols complexity based privacy requirements proposed protocols provide final result privacy private input privacy
background late high throughput microarray sequencing data extensively used monitor biomarkers biological processes related many diseases support vector machine svm used successful gene selection many applications despite benefits single data analysis using small mid size data inevitably runs problem low reproducibility statistical power address problem propose meta analytic support vector machine meta svm accommodate multiple data making possible detect consensus genes associated diseases across studies results experimental studies show meta svm superior existing meta analysis method detecting true signal genes real data applications diverse data breast cancer mrna expression data lung disease idiopathic pulmonary fibrosis ipf applied result identified gene sets consistently associated diseases across studies particular ascertained gene set data found significantly enriched abc transporters pathways known critical breast cancer mechanism conclusion meta svm effectively achieves purpose meta analysis jointly leveraging multiple data facilitates identifying potential biomarkers elucidating disease process
nowadays power dominant factor highly integrated hardware systems designs implied problems high power density causing chip limited power source modern internet things devices commonly dealt use dynamic power management method enables use power reduction techniques clock gating power gating voltage frequency scaling since adoption power management quite difficult modern complex systems new approaches evolving intended simplify power constrained systems design also proposed approach utilizing system level design abstraction increased automation design process paper proposed hybrid verification approach described represents integral part suggested design methodology consists formal informal techniques enabling verification process begin early specification stage system development approach helps designer create correct consistent power management specification verifies whether specified power intent preserved design refinement continuous automated verification steps quickly find errors early design stages thus reduce amount design speeds overall development process
purpose article elucidate development problem nonverbal means communication condition reflection formation communication children speech research technique characterise nonverbal encoding decoding nonverbal means communication offered authors experimental study nonverbal encoding decoding carried also analysis obtained experimental data provided authors published ltd open access article license
paper present fpga implementation discrete wavelet transform used image compression lifting based wavelet transform modeled simulated using matlab dsp implementation methodologies used optimize required hardware signal flow graph dependence graph derived optimized implement hardware description circuit circuit code synthesized realized using field programmable gate array fpga family post synthesis simulations confirm circuit operation efficiency
purpose study examined effectiveness universal pressure prevention bundle applied intensive care unit icu patients combined proactive nurse rounds compared standard guideline referral based nurse involvement measuring adherence evidence based prevention interventions incidence pressure ulcers design study used quasi experimental pre design phase included different subjects descriptive methods assisted exploring content nurse rounds subject setting one hundred eighty one pre subjects met inclusion criteria admitted icu hours participated study research setting located north medical center methods data collection included admission discharge skin assessments chart reviews evidence based interventions patient characteristics nurse logs study subjects intact skin admission identified initial skin assessment enrolled subjects received standard care subjects received skin assessments icu discharge chart reviews throughout stay determined presence unit acquired pressure ulcers skin care received analysis included description nurse rounds tests guideline adherence multivariate analysis intervention effect pressure incidence unit assignment scale score icu length stay covariates multivariate model based bivariate logistic regression screening results incidence unit acquired pressure ulcers decreased nurses rounds months focusing primarily early detection pressure sources data analysis revealed significantly increased adherence elevation multivariate logistic regression modeling showed significant reduction unit acquired pressure ulcers intervention increased square value including covariates final model value conclusion nurse rounds resulted statistically significant clinically relevant reduction incidence pressure ulcers
paper introduced improvement original control system process control laboratory development liquid level temperature flow time sharing control experiment platform adopting technology newly designed control system using master control unit control unit touch screen upper computer able achieve real time monitoring spot operation adjust control parameters centralized management provide convenience practical operating results show platform extends function equipment improves utilization rate equipment also help students understand master advanced control technologies technology application touch screen process control engineering research control algorithms
cannabis sativa cannabis plant contains aromatic hydrocarbon compounds called delta abundant main psychotropic constituent activate two types protein coupled receptors type receptor type receptor ongoing interest development research explore therapeutic potential cannabis delta exerts biological functions gastrointestinal tract cannabis used treatment disorders abdominal pain diarrhea system endogenous circulating performs protective activities tract presents promising therapeutic target various conditions inflammatory bowel disease especially crohns disease irritable bowel syndrome secretion motility related disorders present review sheds light role cannabis gut liver pancreas also symptoms nausea vomiting syndrome anorexia weight loss chronic abdominal pain although current literature supports use treatment digestive disorders clinical efficacy cannabis constituents various disorders remains unclear copyright wolters kluwer health inc rights reserved
paper based practical engineering design case northeast china combined actual engineering situation local climatic conditions technical method integrated design solar water building investigated provides reference guidance application solar energy residential building design conducive promoting wide use renewable energy green residential building
elevated levels risk factor late onset alzheimers disease associated changes cell methylation alzheimers disease characterized upregulation whose promoter regulated methylation however whether activates enzymatic pathway influencing methylation status promoter remains unknown brains mice high assessed pathway neuronal cells exposed implemented study mechanism regulating expression levels effect amyloid formation diet genetically induced high resulted protein mrna upregulation associated significant increase ratio reduced dna dna vitro studies confirmed results demonstrated mechanism involved dependent activation amyloid formation dna secondary elevated levels taken together findings represent first demonstration directly influences expression levels establish previously unknown cross talk two pathways highly relevant pathogenesis discovery novel link provides new mechanistic insights neurobiology importantly new therapeutic opportunities individuals bearing risk factor disease
active speakers traditionally identified video detecting moving paper demonstrates using spatio temporal features aim capture cues movement head upper body hands active speakers directional information obtained using sound source localization array used training video features
purpose green range organizations including businesses universities recent decades within higher education academic libraries key service unit parent institution important role play supporting mission authors seen many academic libraries green designing green library whether new build paper aims discuss issues design methodology approach paper discusses chinese university hong kong library develops implements green strategy strategy gradually services first authors consider concept sustainability affected services provided academic libraries green strategies practical feasible approach authors use library case study development green strategies context approach sustainability wider community ultimately overall strategic plan third section describes library implements green strategies different areas daily operation library offices services offered users planning library extension broader sustainability initiatives issues evaluation discussed authors conclude paper future plans findings academic libraries usa leadership energy environmental design certified originality value authors argue green building strategic focus many academic libraries taking holistic approach sustainability practical measures academic libraries need formulate develop wider green strategies beyond green building green impacts attitudes towards environment also changes way academic libraries serve users community
bipolar disorder characterized sleep dysregulation suggesting role activating system ras postmortem studies showed increased expression neuronal calcium sensor protein brains bipolar disorder patients reduced aberrant gamma band activity present disorder lithium shown effectively treat mood disturbances bipolar disorder patients previously showed low levels increased high levels decreased gamma oscillations ras neurons decreased oscillations previously described effects agent oscillations protein mechanisms currents however designed present experiments determine nature interaction physiological concentrations effect within minutes application expected decreased gamma oscillation amplitude increased amplitude gamma oscillations identified mol concentration increased gamma oscillations within min mol concentration decreased gamma oscillations within min combined application concentrations showed reduced effects oscillation amplitude within min results demonstrate physiological levels acts reduce effects given expression effects
purpose evaluate corneal parameters patients ankylosing spondylitis imaging also clarify associations disease severity clinical status corneal parameters methods fifty seven patients healthy subjects included cross sectional study participants underwent detailed evaluation corneal parameters measured addition test tear break time corneal staining ocular surface disease index scores evaluated duration disease scores bath ankylosing spondylitis disease activity index basdai ankylosing spondylitis quality life scale patients recorded laboratory evaluation consisted human leukocyte antigen hla erythrocyte sedimentation rate esr reactive protein crp results corneal parameters significantly different patients healthy controls mean central corneal thickness versus mean corneal volume versus reduced significantly patients compared healthy controls values test scores significantly lower patients controls also corneal staining scores higher patients controls factors related corneal parameters dry eye tests test corneal staining score crp conclusion patients thinner compared control subjects affected tear inflammatory processes
lesbian gay couples definition establish sex specific domestic tasks least previous research shown high levels equality characterize domestic work arrangements sex couples study explanations theoretical background stems family economics theory relative resources gender role life course considerations empirical analysis based upon generations gender survey france netherlands norway sweden australia results show sex partners engage tasks equally sharing pattern less partners workload equally balanced comparative advantages life course differences gender roles contribute explanation higher levels equality sex compared different sex relationships
measuring estimating number errors violations functional dependency offers valuable information data semantics quality existing work focuses error estimation centralized environment data stored one site goal optimize time space complexities estimation algorithms distributed error estimation problem data reside multiple physically distributed sites never studied depth subject work work study version distributed error estimation problem site multiple remote sites estimations goal minimize communication cost study two types queries dual semantics estimations one tries maximize accuracies error estimations fixed communication costs minimize communication costs needed meet certain accuracy requirements framework remote site maintains concise data structure obtained scanning local data site receives processes data structures estimate error solution extends case two remote sites multiple remote sites demonstrate efficacy proposed techniques via rigorous analysis extensive experiments elsevier inc rights reserved
painful inflammatory complication occurring patients borderline patients significant cause economic morbidity mortality patients understanding causes limited performed systematic review published literature critically evaluated evidence role neutrophils immune complexes ics cells cytokines immunological factors contribute development searches literature performed pubmed studies independent published date using samples patients included search revealed articles eligible studies included systematic review studies demonstrate associated clear whether mediated process presence ics increased levels tumor necrosis factor pro inflammatory cytokines support role cytokine inflammatory phase necessarily initiation cell subsets appear important since multiple studies report increased ratio skin peripheral blood patients microarray data identified new molecules whole pathophysiological pathways associated provides new insights pathogenesis studies often difficult compare due lack case definitions treatment status timing sampling use different laboratory techniques standardized approach issues useful appears complex interaction various aspects immune system rigorous clinical descriptions defined cohorts patients systems biology approach using available technologies genomics proteomics yield greater understanding condition
integrating micro flood irrigation field rainwater harvesting proposed experiments conducted production season experimental farm university free state south africa three water regimes supplemental full irrigation tested runoff strip width determine effects soil water balance components integrated four blocks nine prepared split plot factorial experimental design plots long standard width site specific data used estimate rainfall runoff deep drainage functions soil water content measured neutron water meter partitioned evaporation using beta parameter deep drainage least significantly affected less significantly higher gains change dry significantly higher deficit reproductive growth stages evaporation constituted less compared less significantly higher irrespective water regime highest values irrigation treatments therefore used either optimize soil water balance integrated water management
long span suspension bridges satisfy time spanning long distances limited responses external loads even high intensity structural control offer reliable contribution limit internal forces displacements structural elements extreme events occur wind regarded one important dynamic excitation long span flexible bridges owing low frequency content characterize spectrum paper suspension bridge model steel frame deck accounted case study performing numerical simulations evaluating first wide collection control strategies including tuned mass mitigating dynamic vibrations induced strong wind loading subsequently scope extended reference issue robustness control strategies assessing proposed control solutions respect changes parameters control implementations include optimal tuned mass damper schemes identified reduced two degrees freedom structural model efficacy tested full bridge finite element model passive control strategy compared different ones implementing passive semi active link deck hybrid control schemes adopt time tuned mass important issue robustness control strategies studied reference proposed control schemes hence proposed control solutions evaluated respect capability perform satisfactorily behavior damage elements occurs besides numerical simulations necessary derive quantitative approach formulation evaluation robustness index control system explored reasons base satisfactorily behavior observe highlighted civil ltd elsevier ltd rights reserved
introduction due recent advancements understanding molecular pathogenesis cell malignancies explosion innovative agents development purpose review efficiently summarize novel therapies activity non hodgkin lymphoma targeting surface antigens signaling pathways tumor covered literature search performed identify preclinical data clinical trials focused use targeted therapies subtypes including follicular lymphoma marginal zone lymphoma small lymphocytic lymphoma lymphoma classes reviewed include monoclonal antibodies antibody drug conjugates immunomodulatory agents cell receptor pathway inhibitors bcl inhibitors checkpoint inhibitors chromatin epigenetic modulating agents car commentary opinions regarding strategies address prioritization novel agents entering clinical development determination rational combination therapy development novel endpoints clinical development movement towards novel approaches immuno cellular therapy attempt provide curative treatment options provided also economic impact therapy discussed
aim study analyze etiology incidence sports injuries among players moreover verified levels aggressiveness anger presented athletes roles team influenced incidence severity injuries study involved male players members polish national team month period athletes participated training study based competitive aggressiveness anger scale registry sports injuries consulted non consulted physician demographic questionnaire following observations made month period corresponding mean training days players experienced primarily minor injuries require medical intervention four injuries needed consulted physician sports injuries occurred frequently among players defensive players players showed tendency higher levels anger aggressiveness defensive players concluded discipline associated high incidence minor injuries require medical intervention incidence rate injuries analyzed period per athlete per training day
background article reports evaluation psychometric properties clinically important difference threshold performance based skills assessment major depressive disorder mdd using data large scale study effects cognitive functioning functional capacity mdd patients methods adults moderate severe recurrent mdd self reported cognitive dysfunction randomized weeks double blind treatment flexible placebo pearson correlation coefficients calculated composite score demographic disease characteristics baseline examine construct validity two methods distribution based based used establish threshold results total patients randomized comprised full analysis set entire sample mean composite scores baseline week mean change hypothesized baseline composite score correlated cognitive functioning digit symbol substitution test workplace productivity work limitations questionnaire depressive symptoms depression rating scale subjective cognitive dysfunction perceived deficits questionnaire limitations two versions used inclusion exclusion criteria based conclusions results support construct validity assessing functional capacity independent mood symptoms estimated changes scores quite consistent points based distribution based based methods respectively
smoking cessation adolescents considered developmental context enable clinician appropriate assessment management young person seeing whether primary tertiary care setting adolescence time rapid neurocognitive hormonal change factors affected personality behavioural factors family cultural psychosocial context adolescents uniquely vulnerable smoking initiation nicotine addiction throughout years increased awareness risks smoking using opportunities assess intervene regarding smoking cessation integral clinical practice clinicians seeing young people review discuss demographics adolescent smoking risk factors assessing smoking nicotine addiction importance brief interventions evidence base appropriate interventions particularly high risk groups innovative training health professionals adolescent smoking cessation elsevier ltd rights reserved
clinical studies indicate reciprocal impact nicotine use antipsychotic medications patients schizophrenia present study used conditioned avoidance response car test behavioral test antipsychotic effect examined specific drug drug interactions nicotine following acquisition avoidance response rats first tested either vehicle nicotine combination nicotine nicotine seven consecutive days challenged nicotine car assess affected behavioral effect nicotine avoidance response nicotine altered avoidance suppressive effect seven avoidance drug test days nicotine alter avoidance suppressive effect however challenge test prior nicotine treatment attenuated sensitized effect avoidance response hand prior treatment increased avoidance disruptive effect even nicotine exhibit acquired avoidance suppressive effect combined nicotine treatment produce detectable interactive effects avoidance response motor activity findings suggest nicotine capable altering long term antipsychotic efficacy alter behavioral effects nicotine nicotine less likely influence
study investigated human gastrointestinal uptake subsequent whole body retention orally administered inorganic radioactive cobalt eight adult volunteers aged years seven given solutions containing stable cobalt carrier six given carrier free administered activities ranged observed mean based days accumulated urinary excretion sampling whole body counting carrier free carrier associated values reasonable agreement values reported previous studies involving single intake inorganic cobalt time pattern total retention including residual cobalt tract included short term component biological half time average standard error mean two intermediate component mean half time long term component observed two volunteers half times ranging two present data conclude short lived internal absorbed dose delivered within days following oral intake high individual variation influenced transit time cobalt intestinal tract elsevier ltd rights reserved
important potential learning system ability adapt based learners status order support personalized learning however requires using specific learners parameters factors control adaptation process include learning style presentation preferences progress preference subject paper presents web based system support students learning computer programming novelty system using cognitive process levels revised taxonomy factor adaptation learner progress system moves learner simple levels complex ones
background purpose pancreatic uncommon reports describe investigated clinical influence caused methods subjects prospective cohort study patients underwent preserving reviewed relationships pancreatic duct pancreas several risk factors also compared pancreatic duct pancreatic atrophy analyzed nutrient parameters first postoperative year results patients preoperative pancreatic duct diameter less significantly postoperative pancreatic duct diameter average atrophy rate pancreas lowest atrophy rate seen patients without pre postoperative pancreatic duct dilation normal pancreas pancreatic duct developed postoperatively high atrophy rate moreover patients without pre postoperative pancreatic gained body weight conclusions study shows significant correlation pancreatic atrophy rate weight loss atrophy pancreas caused influences function patients method improved prevent pancreatic duct allow early diagnosis management lesions
studies examined association parenting behaviors childhood post traumatic stress disorder ptsd yielded mixed findings clarify role parenting childhood ptsd conducted systematic review meta analysis studies investigated association parenting youth ptsd symptoms total negative parenting behaviors hostility accounted variance childhood ptsd symptoms positive parenting behaviors warmth support account variance negative positive parenting child ptsd symptom associations statistically differ magnitude moderator analyses indicated methodological factors trauma variables affect association parenting child ptsd studies relied upon questionnaire measures general parenting style studies predominantly cross sectional weaker evidence found longitudinal studies given small number high quality studies available recommendations role parenting childhood ptsd made authors published elsevier ltd
evidence building pathologic drive development osteoarthritis involves simple mechanical wear tear inflammatory mechanisms play important role tissue response joint injury involved development post traumatic inflammation also appears integral progression whether post traumatic spontaneous contributing evolution joint tissue degradation remodeling joint pain patient based studies vivo models disease light number inflammatory pathways mediators impact various aspects disease structurally recent work field implicated inflammatory chemokines osteoarthritis pathogenesis expression multiple chemokines receptors modulated disease patients animal models although best known effects leukocyte migration trafficking within immune system chemokines wide variety effects non cell types impacting proliferation differentiation activation cellular responses role models also demonstrated diverse effects disease exemplify wide ranging effects understanding important mediators inflammation impact joint disease whether targeted therapeutically actively investigated many groups field narrative review focuses evidence published within last years highlighting chemokine mediated pathways mechanistic involvement osteoarthritis joint tissue repair orthopaedic research society published wiley periodicals inc
without power political authority planning advice planners little help planners little face political pressure context logical advice planners join politics acquire political authority need plans article case studies united states brazil shows planners politics able accomplish difficult planning tasks suggests planners take position possible
past research shown individuals low prejudice think carefully information individuals non individuals one explanation effect heightened stems motivation potential prejudice toward others motivation present research tested variation hypothesis based idea implicit specifically argue among individuals low explicit prejudice also relatively high implicit automatic prejudice processing prejudice relevant contexts implicit framework also makes novel prediction individuals relatively high explicit prejudice low implicit prejudice also engage enhanced information processing predicted people racial implicit explicit attitude discrepancies regardless direction discrepancy found engage greater message black faculty study message black job candidate study even black concept merely primed prior reading race irrelevant message study elsevier inc rights reserved
main aim study treatment assignment criteria used clinical centre addiction treatment spain sample patients inpatients outpatients sought treatment assessed clinical characteristics addiction severity psychopathological symptoms two treatment groups inpatient outpatient patients assigned according clinical criteria therapists analysed identify variables relevant patient placement moreover therapeutic progression patients met meet assignment criteria received studied according results score family social support area european addiction severity index cases score family social area score partner subscale scale correctly classified cases inpatients outpatients comparisons therapeutic results depending matching assignment criteria showed larger effect size patient assignment criteria outpatient treatment results obtained study provide objective criterion patient placement moreover cost effective perspective question necessity inpatient treatment cases demonstrating outpatient treatment sufficient level care study addresses approach assigning patients treatment modality best fits implementing least expensive level care needed achieve treatment success elsevier inc rights reserved
management daily stress greatly improved delivering sensor triggered just time interventions mobile devices success critically depends able mine time series noisy sensor data find moments paper propose time series pattern mining method detect significant stress episodes time series discontinuous rapidly varying stress data apply model weeks physiological gps activity data collected users natural environment discover patterns stress real life find duration prior stress episode predicts duration next stress episode stress lower day analyze relationship stress objectively rated disorder surrounding neighborhood develop model predict stressful episodes
population continues experience high rate unintended pregnancies impact individual families society alike lack effective contraception accounts unintended pregnancies along incorrect use contraceptives common reversible contraceptive method used united states oral contraceptive pill significant failure discontinuation rates use long acting reversible contraceptive methods increasing recent years efforts educate providers patients women likely use methods barriers access cost removed uptake use methods allow markedly reduced contraception failure rates higher user satisfaction thus higher continuation rates seen current contraception use promoting use methods important strategy improving individual public health outcomes reducing unintended pregnancies pharmacists role family planning expanding contribute efforts although knowledge regarding studied among pharmacists knowledge deficit exists among health care professionals general thus pharmacist education training include methods along contraceptives american college clinical pharmacy womens health practice research network advocates pharmacists role use safe highly effective methods roles include educating patients informing providers facilitating access providing referrals modifying institutional procedures encourage provision methods
recently investigations relationship media violence exposure aggressive behavior focused brain functioning study examined relationship brain activation history media violence exposure adolescents using functional magnetic resonance imaging fmri samples adolescents psychiatric diagnosis disruptive behavior disorder aggression compared investigate whether association history brain activation moderated aggressive behavior personality twenty two adolescents history aggressive behavior diagnosis either conduct disorder oppositional disorder sample controls completed emotional task fmri primary imaging results indicated controls history low demonstrated greater activity right inferior frontal gyrus anterior cingulate violent word condition contrast adolescents high exhibited decreased activation right amygdala compared low findings consistent research demonstrating importance limbic structures processing emotional stimuli research suggesting media violence affect individuals different ways depending presence aggressive traits elsevier ireland ltd rights reserved
micrornas mirnas endogenous small non coding rnas regulate gene expression level regulate tolerance abiotic stress however studied clone important bio indicator measuring effect radiation date gamma irradiation gamma responsive mirnas expressions patterns plants response gamma stress reported yet therefore putative gamma responsive mirnas cdna library radiation stress predicted study using comprehensive genomic approaches identified mirnas belonged different mirna families quantitative real time polymerase chain reaction qrt pcr analysis five randomly selected mirnas confirmed responsiveness gamma stress target prediction revealed mirnas targeted genes involved stress tolerance regulation light response redox systems signaling pathways dna repair transcription factors coordinated reverse expression changes mirnas target genes validated predicted mirnas gamma responsive likely directly involved stress regulatory networks altogether results provide novel insights understanding molecular mechanisms mirnas involved plant response gamma
introduction considerable amount controversy long term effects duration breast feeding maternal bone mineral density menopause study conducted determine whether multiple pregnancy prolonged duration breast feeding independent predictors low bone mass post menopausal women methods retrospective study evaluated post menopausal women mean age years screened osteoporosis dual energy ray absorptiometry dxa according parity children total duration breast feeding months classified bone mineral density bmd results femoral neck lumbar spine classified three groups normal osteopenia osteoporosis according criteria binary logistic regression used assess independent associations low femur spine bmd parity total duration breast feeding results found women children months history total breast feeding older higher prevalence osteoporosis however adjusting age parity independent predictor osteopenia total duration breast feeding independent predictor low bone mass conclusion detrimental effect maternal bmd history multiple pregnancy risk factor low bone mass post menopausal women however prolonged duration breast feeding long term adverse effect maternal bmd post menopausal age
paper presents overview use goal oriented strategies output based aid payment environmental services water pollution control urban rural areas throughout country thus considering goal implementing two nation wide experiences reviewed river basin clean program water program run national water agency former initiated decade ago illustrate successful ways bring public authorities water users together case services respectively finally discussed applicability perspectives carrying new goal oriented initiatives aimed brazil
generalized bilinear operators based prime number hirota like equation proposed rational solutions generated graphically described using symbolic computation software maple elsevier ltd rights reserved
objectives patients common mental disorders often suffer comorbidities limit functioning work assessed longitudinal impact defined two occurring chronic health conditions work functioning time among workers returned work sick leave due methods prospective cohort study workers followed year return work sick leave due score computed counting severity weighted chronic health conditions measured baseline work functioning measured baseline months follow work role functioning questionnaire work functioning trajectories course work functioning return work time identified latent class growth analysis results total workers four work functioning trajectories identified one workers showed increasing work functioning scores follow whereas trajectories showed low medium high scores respectively remained stable across time points although predict membership trajectory within increasing score trajectory levels work functioning lower among high baseline score conclusions time negatively impacts work functioning return work sick leave due
challenge protein based therapies ability produce biologically active proteins ensured delivery various approaches utilised including fusion protein transduction domains protein interest issue lack specificity efficiency indeed whether protein actually cell merely fixation process present novel platform allowing inducible export uptake protein interest system combination system combined fusion protein containing terminal signal peptide human beta subunit terminal poly arginine domain efficient uptake target cells novel platform validated using enhanced green fluorescent protein gene interest efficiently induced expression fusion protein human beta subunit facilitated export fusion protein cell culture media finally fusion protein able efficiently enter cells target cells mediated poly arginine cell penetrating peptide importantly addressed issue whether observed uptake fixation process indeed genuine translocation addition platform provides number potential applications diverse areas stem cell biology immune therapy cancer targeting therapies elsevier rights reserved
extraction one important issues hyperspectral image analysis linear mixing model pure pixel assumption number convex geometry based methods developed past decades however traditional methods generally produce unsatisfactory results since require hyperspectral image convex structure exactly case real image scene particle swarm optimization pso algorithm recently employed address extraction problem performance limited premature convergence lower precision standard pso much effort required enhance optimization result address problems study novel quantum particle swarm optimization algorithm proposed hyperspectral extraction notable advantages proposed method include row column coding approach particles designed accelerate optimization process cooperative approach employed update particles individual global best positions order help particles optimization behavior multidimensional search space two kinds objective functions namely maximizing simplex volume formed combination minimizing root mean square error original image image incorporated sequential optimization approach extraction problem makes algorithm robust outliers acceptable time cost extensive experimental results prove able find optimal combination
chapter discusses several methods forward looking explosive hazard detection using infrared ground penetrating radar challenge detecting explosive hazards sensors multiple types targets buried different depths highly environment wide array target signatures exist makes detection algorithm design difficult recent work application focused fusion methods including fusion multiple modalities sensors fusion multiple frequency sub band images feature level fusion using multiple kernel learning chapter demonstrate several types techniques including kernel methods support vector machines multiple kernel learning feature learning methods including deep learners learning demonstrate performance several algorithms using data collected test site summary work deep belief networks evolutionary approaches feature learning shown effective based
measured displacement sensor displacement provide better estimation longitudinal muscle stiffness measured acceleration sensor acceleration displacement provide transverse muscle stiffness propose method estimate longitudinal transverse muscle stiffness velocity using system identification technique aims study show advantages proposed method velocity measured using capacitor differential circuit evoked electrical stimulation anterior muscle measured five times seven healthy young male volunteers evoked system identified using singular value decomposition method approximated fourth order model provides two natural frequencies corresponding longitudinal transverse muscle stiffness fluctuation natural frequencies estimated velocity significantly smaller acceleration significant difference fluctuations natural frequencies estimated velocity displacement proposed method using velocity thus advantageous muscle stiffness estimation elsevier ltd rights reserved
material forming industry urgently needs high quality engineering technical skill practical operation ability using kinds digital tools independent die design manufacture paper analyzes material forming industry situation development trend current situation shanghai demand training results showed people possessing one post multidisciplinary knowledge multi capacity realizing future development demand exceeds supply provide support breakthrough professional positioning cultivation aim determining
paper new linear actuator developed actuator made mimic biological muscles structure function ionic polymer metal composites smart material used motion cross bridges biological muscle dynamic model proposed actuator developed using wave propagation technique modeling simulation actuator shows one muscle unit actuator produces maximum force axial displacement step maximum axial displacement total muscle unit length sixteen sets used set contains three segments connected series length width height segment respectively total muscle unit length diameter respectively
distribution five families species complex studied comparing results southern blotting technique males females situ hybridization degree structural polymorphism family different species also investigated restriction enzyme analysis found genomic distribution trait depends family species distribution mainly four species distribution families markedly different families mainly species elements located chromosome differences genomic distribution unrelated structural conservation relation distribution phylogeny activity role host genome discussed
indirect hysteresis voltage digital control proposed single phase half bridge inverters slow response switching modulation difficult control voltage hysteresis method directly study output voltage controlled indirectly using adaptive band hysteresis current control fast response robustness independent system parameters reference current computed based desired reference output voltage hysteresis band controlled maintain switching frequency constant value simulation results show good performances proposed control method cases reference output voltage
urban geological hazards involving ground instability costly dangerous affect many people yet little information extent distribution within urban areas reason measuring ground instability associated many processes often hidden buildings conventional geological survey detection techniques satellite radar offers remote sensing technique map scale deformation wide areas given suitable multi temporal data space project named used map areas unstable ground cities representing similar population partnership national geological surveys project developed standardised mapping methodology recorded instances types covering presented analysis results project output data provides insights distribution european urban frequency probability occurrence merging data data provides systematic estimate population exposures satellite radar shown valuable tool systematic detection mapping urban phenomena elsevier rights reserved
trauma memories feel memories problematic legal contexts examined whether feeling makes people susceptible suggestive questioning direct examination whether cross examination examined whether cross examination uncover correct distorted trauma memories showed participants film depicting graphic car accident participants film temporally way interviewed participants immediately film regarding seen direct examination included free recall recall yes questions misleading hours later second cross examined participants contrary predictions neither manipulation films temporal organisation participants self reported feelings event significantly affected accuracy film direct cross examination recognition memory film instead found regardless whether participants memories distorted direct examination suggestive nature cross examination introduced sufficient participants willing change answers conclude traumatic memories vulnerable suggestive questioning unfortunately cross examination legal systems fail safe corrective influence
previous studies indicate gaseous messenger carbon monoxide released eye venous blood depending intensity sunlight study designed determine whether increased concentration venous blood affects synthesis melatonin therefore whether released eye normal lighting conditions carrier light intensity information thirty six mature male wild pig studied measured difference melatonin pathway response terms mean concentration increased melatonin levels hours infusion autologous blood plasma experimentally induced approximately fold increase concentration venous sinus demonstrated marked variation duration amplitude nocturnal melatonin peak response increased concentration venous blood winter treatment limited nocturnal melatonin rise summer experimental treatment enhanced nocturnal melatonin rise changes melatonin levels always associated parallel changes protein levels work demonstrates non physiological changes concentration venous blood acute impact systemic melatonin level results support humoral mechanism bright effects animal treatment winter seasonal affective disorder
purpose investigate utility exome sequencing define molecular diagnosis patients clinically diagnosed congenital anomalies kidney urinary tract methods performed families data analyzed single nucleotide variants known genes deleterious sequence changes new candidate genes potentially disease associated copy number variants results approximately families pathogenic identified observed phenotypes families expand current understanding role genes four pathogenic also identified using two detection tools addition found one deleterious novo among families clinical database genetics laboratory seven additional unrelated individuals novel novo identified six eight individuals urinary tract defects gene urinary tract development conclusion conclude used identify molecular etiology subset individuals also help identify novel genes
cloud computing specialized form distributed computing resources storage processors memory etc completely abstracted consumer number cloud service providers offer computing service increased recent times often customers need interact unknown service providers carry transactions open anonymous environments trust helps build consumer confidence provides reliable environment trust based ranking system also help choose services per requirement paper multi criteria decision making methods used rank service providers based infrastructure parameters combination analytic fuzzy method gives better trust estimate compared analytic method alone
osteoarthritis progressively degenerative joint disease influenced structural metabolic factors growing evidence bone involved symptomatic structural progression wnt pathway implicated progression expression function wnt inhibitors unclear examined regional distribution bone femoral head using resection specimens following arthroplasty patients presenting end stage cylindrical cores immunohistochemistry taken full thickness cartilage defect partial cartilage defect base normal cartilage bone cores taken regions full cartilage defect cores taken regions bone expression observed exclusively expression highest bone cores taken regions partial full thickness cartilage defects expressed chondrocytes cores normal cartilage current study describes regional cellular distribution hip expression highest bone underlying partial thickness cartilage defects however clear cause consequence alterations cartilage however suggestive active remodeling process targeted disease modifying agents
dynamic interplay known exist auditory processing human cognition example prior investigations speech noise revealed learning just listening even words within list correctly heard noise later memory words typically investigations supported view gap speech memory speech notion gap speech function extent message limited immediate memory resources accordingly difficult processing message less resources available elaboration storage recall material however previously known increasing difficulty affected memory processing semantically rich material investigation showed noise impairs higher levels cognitive analysis variant deese roediger mcdermott procedure encourages semantic processes deployed trial participants item list comprising words blocked different themes words bed associated critical theme word presented sleep word lists either presented without noise signal noise ratio upon weighting noise reduced false recall critical words decreased semantic clustering recall theoretical practical implications discussed
demand management residential buildings key component toward sustainability efficiency urban environments recent advancements sensor based technologies hold promise novel energy consumption models better characterize underlying patterns paper propose probabilistic data driven predictive model consumption forecasting residential buildings model based bayesian network framework able discover dependency relations contributing variables thus assumptions often made traditional forecasting models moreover able efficiently capture uncertainties input variables quantify effect system output test proposed approach data provided pacific northwest national lab collected pilot smart grid project examine performance model multiscale setting considering various temporal min hourly intervals spatial households region household resolutions analyzing data demand forecasting individual households levels first step toward designing personalized targeted policies customer widely studied topic digital marketing researches done energy sector results indicate bayesian networks efficiently used probabilistic energy modeling residential buildings discovering dependencies variables elsevier ltd rights reserved
introduction surveys collect information injuries often focus single serious event help limit recall error reduce survey length however mask less serious injuries result biased incidence estimates specific injury methods data health behaviour school aged children survey canadian hospitals injury reporting prevention program used compare estimates sports injury incidence canadian children results data indicate children report sustaining sports injury required emergency department visit however details collected childs serious injury children multiple injuries requiring visit sports injuries went rate seen underestimate much corresponding surveillance data indicate incidence potential bias also highlighted analysis injuries attended health care providers conclusion one serious injury line questioning induces potentially substantial bias estimation sports injury incidence limits researchers ability quantify burden sports injury longer survey recall periods naturally lead greater design future surveys take issues account order accurately inform policy decisions direction future research researchers aware limitations
previous studies showed cultured mouse stem cells rapid proliferation normal maintenance potency least spontaneous differentiation lowest level stress activated protein kinase incubated rather traditional hypoxic conditions switching induced fast responses tested dose response amp activated protein kinase active form levels also tested whether levels show similar rapid changes cultures switched optimal conditions delayed increase levels similar switching conditions altering conditions either led rapid increase levels within similar previously reported response cells removed twelve hours exposure led cell program changes terms potency loss suppressed biosynthesis indicated levels phosphorylated inactive acetyl coa phosphorylation acc inhibited inhibitor compound however unlike stressors mediate hypoxia induced potency loss results suggest important aspect stem cell biology demands rapid stress enzyme activation cope sudden changes external environment least stressful stressful conditions
introduction despite antiretroviral therapy art challenges remain ensuring timely access care treatment people living hiv part multi country study investigate hiv mortality conducted health facility surveys within health demographic surveillance system sites across six countries eastern southern africa investigate clinic level factors influencing use hiv testing services use hiv care treatment iii patient retention art methods health facilities sampled within surveillance sites kenya south africa structured questionnaires administered charge staff members hiv testing prevention mother child transmission art units within facilities forty one indicators influencing uptake patient retention along continuum hiv care compared across sites using descriptive statistics results number facilities surveyed ranged six eighty percent lower level facilities district referral hospitals client load varied widely less one hiv testing clients per provider per week facilities delivered services interventions support patient retention care delivering free services offering within care pre art monitoring adherence counselling many facilities delivered several areas however targeted testing high risk groups mobile testing also intra site inter site differences including delivery option ranging nurse led art initiation ranging facilities require additional lab tests art initiation stock hiv test kits antiretroviral drugs particularly common conclusions identified high standard health facility performance delivering strategies support progression continuum hiv care hiv testing policy practice particularly weak inter differences quality coverage represent opportunities improve delivery comprehensive services people living hiv
aim study evaluate effectiveness tolerance tendency enhancement program prepared enhance tolerance tendency reduce bullying level fifth grade students pretest posttest follow test control placebo group experimental design used research study carried sample fifth grade students experimental group placebo group control group data used study obtained tolerance tendency scale peer bullying scale wilcoxon signed tests used analyze data results study showed significant change post tests placebo control experimental groups favor experimental group said enhance tolerance tendency reduce bullying level experimental group besides applied experimental group understood permanent effects tolerance tendency conclusion part study suggestions recommendations provided counseling practices researchers light findings
paper present virtual instrumentation system learning operational amplifiers circuits function design analysis combining diagram simulation tools data acquisition board measurement features provided labview real analog signals easily sampled compared signals simulated amp circuits proposed system studied amp circuits different configurations inverting integrator amplifier minimal modifications added circuits configurations inverting differential nonlinear circuits simulated amp circuits models based electrical characteristics components experimental platform consists integrated circuit amp related components configured diagram power supply voltage signals applied input circuit come external source signal generator generated using module generated signals module form voltage sinusoidal triangular rectangular signals parameters easily adjusted software parameter values measured using module specially designed virtual instruments output signal values module manually applied point point input circuit test applied automatically
flux distribution generated field solar central receiver system receiver needs carefully controlled necessary avoid dangerous radiation peaks temperature distributions maximize efficiency keep system safe state tasks imply selecting subset activated assigning one certain aiming point receiver field usually human control supervision potential limiting factor thus active research line define automatic aiming procedures fact general autonomous methodology developed authors work however mathematical modeling leads face complex large scale optimization problem work applying teaching learning based optimization population based large scale considered intended serve perform large search space finally deploy local promising results considering computational cost objective function parallel version developed significantly procedure possibility included complex process remains viable additionally parallel version also linked generic open source library
breakdown blood brain barrier critical step development autoimmune diseases multiple sclerosis animal model experimental autoimmune encephalomyelitis process characterized activated cells across brain endothelial cells main constituents however consequences brain function upon interaction cells largely unknown describe assay allows evaluation primary mouse brain microvascular function barrier integrity interaction cells time assay makes use impedance cell spectroscopy powerful tool studying monolayer integrity permeability measuring changes electrical resistance cell layer capacitance direct contact stimulated naive cells capable inducing monolayer dysfunction visualized decrease increase assay records changes monolayer integrity continuous automated fashion sensitive enough distinguish different strengths stimuli levels cell activation enables investigation consequences targeted modulation cell interaction using wide range substances antibodies pharmacological reagents cytokines technique also used quality control integrity vitro cell assays applications make versatile tool studying properties physiological pathophysiological conditions
causes systemic opportunistic infections immunocompromised individuals particularly infected human immunodeficiency virus hiv rarely hiv negative patients retrospectively analyzed cases patients infected patients divided two groups hiv negative hiv positive cases studied three hiv negative six hiv positive group accompanying lung infection ratio hiv negative group hiv positive patients series laboratory examinations performed bone marrow observed staining disseminated fungal infection associated severe disease symptoms high mortality rates findings indicate timely diagnosis treatment clinicians crucial preventing spread localized infections systemic infections thereby improving prognosis patients published elsevier ltd
paper presents issue mapping database schema within context possible partial loss semantics moreover authors present methodology mapping relational models association oriented model briefly present association oriented one authors novel database productive tool free defects issues described within paper presented terms case study typical example modeling problems concerned within interest bioinformatics
liquid metal electric motor including pair ring electrodes permanent magnet electrolyte solution demonstrated liquid metal sphere along solution stimulated around central electrode rotating speed increases voltage solution serves rapidly remove oxide liquid metal surface reduce motion friction provide liquid metal mass liquid metal increased form kidney like body rotating speed appears controllable effect action solution becomes weak range mass liquid metal increased form circular ring shaped body ideal voltage range controlling rotating motion liquid metal metal fluid speed rpm even extremely low voltage liquid metal electric motor established find important applications chip cooling liquid metal pumps material mixing soft machine realization etc
recent advances flow based microfluidic enabled emergence lab chip devices recognition point care disease diagnostics however adoption flow based hampered today lack computer aided design tools manual design procedures delay product development also inhibit exploitation design complexity possible current fabrication techniques paper present first practical problem formulation automated control layer design flow based microfluidic large scale integration propose systematic approach solving problem goal find efficient routing solution control layer design minimum number control pressure propagation delay intrinsic physical phenomenon minimized order reduce response time valves decrease pattern set time valve actuation two fabricated flow based devices six synthetic benchmarks used evaluate proposed optimization method compared manual control layer design baseline approach proposed approach leads fewer control better timing behavior shorter channel length control layer
focus work model process produce renewable jet fuel products low input specifically non oil used cooking oil taking account fatty acid compositions incorporating reactions methodology provides insight effect composition reactions upon product yields product distribution hydrogen consumption process utilities resulting product hydrogen gas utility demands specific yield range ranged incoming oil diesel range petroleum gas depending upon fatty acid composition hydrogen consumption rate ranged per incoming oil depending upon degree bond thermal energy demand oil processing used cooking oil versus oil respectively owing additional energy required oil extraction electricity demand kwh oil versus kwh oil elsevier ltd rights reserved
several genes risk factors associated parkinsons disease although many genetic markers belong common pathway pathogenetic mechanism yet found also missing heritability analyses estimated part genetic influence contributing found carried whole exome sequencing finnish patients also previous data genome wide association studies gwas cohort variants gene locus associated gwas analysis exome wide gene based association tests also identified genes discovery data set estimated odds ratio variant identified several candidate genes investigation required determine role genes elsevier inc rights reserved
objectives prenatal development brain characterized gestational age specific changes laminar structure brain gestational weeks cerebral patterns normal fetal brain development described histologically postmortem vitro magnetic resonance imaging mri vivo fetal mri purpose study evaluate appearance laminar organization cerebral wall normal abnormal brain development methods retrospective study ultrasound findings normal fetuses fetuses abnormal cerebral patterns gestational age weeks gestation investigated visibility zone relative intermediate zone correlated characteristic findings cerebral gestational age order evaluate transient structures results normal cohort zone interface identified early weeks fetuses examined weeks fetuses zone appeared intermediate zone appeared zone fetuses weeks transition period disappeared variable fashion zone interface identified fetus weeks three patterns abnormal cerebral normal laminar pattern weeks association severe diffuse ischemia exposure focal disruption weeks associated hemorrhage stroke abnormalities dysplasia increased intermediate zone weeks persistence laminar pattern beyond weeks associated type infection mixed focal diffuse pattern two fetuses infection earliest indication infection focal heterogeneity increased intermediate zone development intracranial calcification conclusions fetal intermediate zones demonstrated reliably routine weeks weeks findings represent normal gestational age dependent transient laminar patterns cerebral development consistent histological studies abnormal fetal cerebral patterns gestational age also visible indicate abnormal brain development copyright published john wiley sons ltd
suggest constructive definitions determination finite graphs three periodic nets using two three dimensions possibility constructing graphs nets conclude patterns offer novel class nano structured materials useful features including high internal surface area volume crown copyright published elsevier masson sas rights reserved
considerable research examined infants understanding evaluations social agents two questions remain unanswered first infants organize observed social relations larger structures inferring relationship two social beings based relations third party second infants reason type social relation prominent societies caregiving relation parents series experiments using events ask whether month old infants infer two adult two adults baby one another find infants make inferences make comparable inferences presented visible events specify peer context one adult responds another adult thus infants sensitive least one aspect caregiving organize relations infants adults larger social structures elsevier rights reserved
multi scale modelling approach powerful mathematical technique simulating analyzing complex biological systems human body tool help study interactions various networks living organism cellular level population scale one framework paper generic mathematical model developed describes human metabolism serum metabolites integrated chosen set human metabolic networks new computational approach presented solving resulting dynamic problem using flux balance analysis illustrate performance proposed approach human hepatocyte genome scale model selected metabolic network included simulation results show proposed approach promise respect computational efficiency convergence demonstrate potential application developed model prediction amino acid biomarkers set errors metabolism considered example simulations performed rising matlab toolbox framework potential simulate various human metabolic disorders help diagnosis associated human diseases suggest novel treatment strategies addition opens door new opportunities personalized medicine ifac international federation automatic control hosting elsevier ltd rights reserved
usage fuel cell range full electric vehicle convenient solution address issue shortage range type vehicles compared internal combustion engine range ice fuel cell range potential provide power higher efficiency allow zero emissions operation vehicle even board power source switched range extension work introduction new high temperature proton exchange membrane fuel cell developed framework collaborative european project automotive range high temperature improved light duty full electric commercial vehicle investigated firstly model full electric vehicle created validated means experimental tests carried rolling type approval real world driving cycles model developed effects introduction vehicle range evaluated performances different fuel cell stack systems combined various hydrogen storage system configurations compared hydrogen energy publications llc published elsevier ltd rights reserved
mathematical model two competitive populations two patches manufacturing engineering proposed assumed migration rates two populations constants density dependent led mainly pressure competition conditions persistence system obtained shows appropriate migration rates facilitate two competitive populations populations persistent every patch results confirmed computer simulations also found positive equilibrium globally stable changes equilibrium parameters vary
background respond emergency scenes often uncontrolled settings without aware potential risks makes one dangerous one risk infectious diseases research area predominantly focused compliance use protective equipment attitudes perceptions infectious disease policy exposure rates blood body fluids purpose review determine known impact infectious disease health methods using methodological framework review undertaken allows broad search available evidence results literature search identified eight articles review reported exposure trends lack reported blood borne infections hepatitis hepatitis human immunodeficiency virus hiv instances severe acute respiratory syndrome infections higher prevalence resistant staphylococcus aureus nasal infections amongst conclusions exposure infectious diseases decreasing yet remains significant decrease attributed prevention strategies however knowledge attitudes uncontrolled environment work barrier contraction infectious diseases generally low colonization influenza greater risk acquiring infectious diseases compared general public effect health reported
long day plant red found produce considerable number premature flower placed short light period stress suppression hybridization performed compare gene expression profiles normal flower induced short light periods using reverse northern blotting total positive clones successfully identified sequenced non redundant differentially expressed transcripts obtained according pathway analyses significant distinct cellular component identified notable different metabolic pathways ascribed carbohydrate metabolism lipid metabolism quality libraries verified quantitative real time reverse transcription pcr qrt pcr analysis genes addition six genes demonstrated temporal spatial specificity using qrt pcr implying responsible premature flower abortion furthermore sequence sharing high degree similarity male gene characterized inconsistent expression pattern predicted novel role flower abortion data presented provide insight molecular mechanisms premature flower abortion short light periods hence value assessing candidate genes potential creating novel enhanced photoperiod stress tolerance crown copyright published elsevier rights reserved
size effect whereby strength materials observed increase significantly decreasing depths reported several experimental studies present study series experiments maximum depths varying carefully designed implemented study size effect copper finite element analyses incorporating conventional mechanism based strain gradient plasticity theory requires solid elements performed simulate size effect order circumvent ambiguity associated various methods evaluate hardness size effect investigated fundamental level considering changes load displacement curve finite element results incorporating plasticity theory found good agreement experimental results levels depth conducted present study elsevier rights reserved
objective depressive comorbidity often associated anorexia nervosa antidepressant medication widely used although rely convincing data scientific literature objectives summarize epidemiological physiological psychopathological literature relation manifestations depression focus clinical trial data assessing use antidepressant medication order clarify strategy use antidepressant adolescence method manual search medline performed relevant published studies assessing association depressive signs major depressive disorder mdd another manual search medline listed clinical trials assessing antidepressant results one hand depressive symptoms common course different meaning indeed firstly distinguish symptoms inherent depressive signs instance low self esteem reduced social contacts secondly long term held responsible numerous psychological distortions including anxiety depression symptoms insomnia impaired concentration social isolation natural course also lead depressive moments particular switching type recovery control issues hand mdd also highly prevalent among patients negative prognosis factor thus complex differentiate mdd isolated depressive symptoms inherent symptomatology raises question role antidepressant medication treatment depression significant benefit antidepressant medication shown clinical trials according international guidelines prescribed second line treatment appropriate case authentic depressive disorder data appear frequent use drugs clinical practice discussion nevertheless clinical trials assessing antidepressant treatment suffer methodological weakness concerning size sample choice population evaluation criterion lack proof raise vigilance concerning antidepressant medication prevent clinician using necessary believe indications prescribing antidepressant patients clinical challenge lies differentiation depressive symptoms likely improve without medication signal presence mdd three criterion indicative mdd familial history mood disorder major risk factor mdd among relatives appearance disorders mdd pre exists specific symptoms attributed reactive depressive signs morning insomnia daily variation depressive symptoms suicidal attempts ideation guilt ideation thus integrating data literature review propose pragmatic therapeutic strategy use antidepressant adolescence lies main categories depressive manifestations therapeutic obvious severe mdd comorbid immediate antidepressant required isolated non specific depressive sign medication relevant supposed improve psychotherapeutic support patterns probably frequent situation last case relevant prescribing medication first line antidepressant medication quickly considered presence one several criterion listed persistence despite general medical state fragile population patients evaluated standard blood test ecg treatment paris
platelets critical thrombosis upon detecting injury platelets show range responses including release protein alpha granules synthesized platelet precursor platelets insights alpha biogenesis come studies hereditary conditions granules immature deficient absent studies renal dysfunction arc syndrome identified first proteins essential alpha biogenesis form complex absence either platelets lack alpha granules specific membrane protein gray platelet syndrome gps platelets also lack conventionally alpha granules although containing structures present gps arises mutations affecting gps phenotype benign arc syndrome cause life threatening bleeding progressive thrombocytopenia myelofibrosis review essential roles development also examine existing data mechanisms action many details remain poorly understood ubiquitously expressed arc syndrome disorder causes early life thus clearly involved processes besides alpha biogenesis studies involvement trafficking protein interactions reviewed gain insights roles alpha formation mutations primarily affect platelets little known function insights gained studies related proteins
hadoop become widely used open source framework large scale data processing mapreduce core component hadoop programming paradigm allows massive scalability across hundreds thousands servers hadoop cluster allows processing extremely large video files image files data nodes used implementing content based image retrieval algorithms hadoop compare match query images previously stored image descriptors databases work presents implementation one known algorithms called scale invariant feature transformation image features extraction matching using hadoop platform gives focus utilizing parallelization capabilities hadoop mapreduce enhance performance decrease data input output operations leveraging additionally image processing computer vision tools hadoop image processing open computer vision integration shown
paper shaped thin films examined sem optical microscopy along xrd raman spectroscopy order study effects drying chemical additives concentration printing parameters microstructure phase composition printing attractive way shaping functional materials simple setup low cost digital control possibility obtaining complex forms without post processing make technique highly competitive application common way preparing via powder dispersion involves high temperature treatment degrees order achieve dense uniform structure thus utilized energy efficient gel approach final phase composition achieved situ substrate elsevier ltd group rights reserved
lack longitudinal studies understanding whether visual processing skills significantly influence reading performance present study assessed multi element processing visual processing task comprising non verbal stimuli predominantly related decoding sight word reading one hundred spanish pre reading children evaluated speed awareness letter knowledge early reading level measured first grade third grade four reading lists consisting short long high low frequency words administered results path analyses revealed controlling early reading level significant predictor reading long low frequency words result suggests transparent spanish pre reading significantly linked future decoding skill first study provide empirical evidence pre reading predicts future reading elsevier inc rights reserved
known beta beta play critical role emotional arousal stressful events specific contributions beta subtype psychological disorders largely unknown investigate whether beta involved anxiety like behavior reward addictive drugs conducted series behavioral tests beta knock mice beta mice exhibited increased preference dark compartment closed arm tests light dark box elevated plus maze indicating beta deletion level anxiety innate fear beta mice also showed decreased immobility tail suspension test suggesting beta deletion inhibits depression like behavior interestingly beta ablation change basal locomotion significantly increased locomotor activity induced acute cocaine administration beta mice showed enhanced place preference cocaine attenuated selective antagonist consistently beta agonist suppressed cocaine conditioned place preference data indicate beta deletion enhances acute response reward cocaine results suggest beta regulates anxiety level depression like behavior properties cocaine beta potential targets treatment emotional disorders cocaine addiction
paper deals design pid controller use methods global optimization implemented matlab environment optimization toolbox based minimization chosen integral criterion respect additional requirements control quality overshoot phase margin limits manipulated value objective function also user defined coefficients particular terms different individual requirements often example overshoot phase margin described solution designated continuous linear time invariant static systems order thus efficient real control processes practice
isolated electrical systems lack electrical interconnection networks usually placed geographically isolated areas mainly islands locations developing countries recently diesel generators able assure safe reliable supply exchange high costs fuel transportation system operation transmission system operators increasingly seeking replace traditional energy models based large groups conventional generation units mixed solutions diesel groups held generation important advantages provided renewable energy sources grid codes determine technical requirements fulfilled generators connected electrical network regulations applied isolated grids demanding technical literature rather easy find compare grid codes interconnected electrical systems however existing literature incomplete sparse regarding isolated grids paper aims review current state isolated systems grid codes applicable specifying points comparison defining guidelines followed upcoming regulations
although various factors identified important successful process studies appear undertaken comprehensive analysis using factor analysis systematically categorize views professionals relative importance process critical success factors paper intended fill research gap survey conducted hong kong united kingdom united states australia collect opinions construction professionals regarding construction project factor analysis reliability validity analyses following seven established clients business organization project requirements requirements stakeholders knowledge experience cultural background stakeholders decision making management skills senior project managers competence design team balanced interest stakeholders process although research study involves limited sample size survey findings hands experience relevant industrial practitioners cross referenced similar investigations parts world international comparisons systematically identified categorized enable practitioners construction industry manage process successfully
one main challenges teaching statistics engineering students convey importance conscious presence variability taking account making technical managerial decisions often technical subjects explained ideal deterministic environment article shows possibilities simple electrical circuits bridge among explain students characterize variability transmitted affects decisions additionally used introduce importance robustness showing taking account variability components allows design cheaper products greater benefits one simply apply formulas consider variables exact values results quite unexpected interest motivation students supplementary materials article available online
conventional time series forecast models hardly develop inherent rules complex non linear dynamic systems strict assumptions need always met reality whereas fuzzy time series techniques used even records times series uncertainty instability since need strict assumptions previous study process past observations assigning proper weights fuzzy logical relationship groups ignored lead poor forecasting accuracy since important aspects time series prediction analysis determination future trends depends past observations paper novel high order model constructed make time series forecasting specifically applying search intelligence algorithm optimal lengths intervals tuned moreover regularly increasing monotonic employed fuzzy sets obtain weights ordered weighted aggregation simultaneously weights right hand side fuzzy logical relationship groups explored compensate presence bias prediction part empirical analysis developed model applied predict three known time series numbers enrollment university electricity load demand new south results obtained compared several counterparts including old recently developed models experimental results demonstrate developed model achieve higher accuracy prediction also capture fuzzy features characters elsevier rights reserved
effects classical visual system allowing image formation light acts upon several non image forming functions including body temperature hormonal sleep wake cycle cognitive performance studies shown functions maximally sensitive blue wavelengths comparison longer light wavelengths higher blue light sensitivity reported melatonin suppression vigilance performance improvement also modulation cognitive brain functions studies investigating acute stimulating effects light brain activity execution cognitive tasks suggested brain activations progress subcortical regions involved thalamus hypothalamus brainstem reaching cortical regions associated ongoing task course aging lower blue light sensitivity functions reported first describe neural pathways underlying effects light functions discuss eye cerebral mechanisms associated aging affect light sensitivity thereafter report results investigations cognitive brain sensitivity light course aging whereas impact light cognitive brain responses appears decrease substantially seems remain intact lifespan altogether results demonstrate aging research take account diversity pathways underlying effects light specific functions explain differences light sensitivity
widely used effective drug smoking cessation partial agonist alpha beta acetylcholine receptor full agonist alpha reported formation atherosclerotic plaques alpha apolipoprotein knockout mice however little known effects macrophages atherosclerotic plaques ascertained whether promotes oxidized low density lipoprotein uptake mouse peritoneal macrophages vitro clarified mechanism investigated effects expression receptors like oxidized ldl receptor cluster differentiation receptor class cells expression protein mrna determined western blotting real time quantitative reverse chain reaction respectively effects uptake examined counting number macrophages stained oil red hematoxylin significantly increased expression protein mrna cells increased uptake macrophages effects blocked significantly alpha antagonist alpha beta antagonist beta beta data suggest promotes uptake expression alpha macrophages found significantly activated extracellular signal regulated kinase nuclear factor kappa kappa signaling pathways cells activation blocked beta therefore kappa signaling pathway highly likely responsible induced upregulation expression macrophages processes probably contribute atherosclerotic plaque formation hence increased risk cardiovascular events upon treatment occur considered patients especially suffering cardiovascular diseases elsevier rights reserved
process fine fiber charged polymer solution fiber continuously electrostatic forces evaporation solvent traveling air prior deposition fibers provide high surface area volume ratio high porosity useful many engineering areas biomedical materials engineering one major issue process lack functional model link processing parameters polymer solution properties fiber morphology fiber diameter distribution developed models far functional specific polymer solvent system study present application gene expression programming model prediction fiber morphology polymer solution properties poly ethylene oxide poly ethylene glycol peg solution characteristics surface tension conductivity viscosity relaxation time fed molecular weight mol elastic modulus stress used predictor variables prediction accuracy compared classification regression trees method results show model predicts better model promising morphology prediction
utilizing lens interpersonal implications physical interpersonal distances social contexts set variables present professional discourse away article explores interactive process displayed couple exercise aimed value maintaining explicit level observation clinical practice interpersonal research
patients history food allergy food intolerance common pediatric population encountered frequently perioperative setting pediatric food allergy present spectrum ranging minor acute urticaria severe shock allergy foods including fruits fish egg soy peanut concerning potential cross react perioperative medications little anesthesia literature focuses perioperative management children food allergies educational review provide brief overview classic immunoglobulin ige mediated food allergies less common non ige food allergies present perioperative considerations patients audio summary topic included supplementary audio
oxygen reduction reaction core various applications fuel cells metal air batteries electro generation depending targeted application catalysts follow direct four electron pathway two electron pathway systematically investigated impact loading rotating ring disk electrode activity selectivity towards alkaline medium four representative catalysts including metal catalyst commercial metal free catalysts carbon black graphene non metal catalyst selected exhibit different behaviours following direct four electron pathway two electron pathway series pathway results confirmed catalyst loading influences activity selectivity catalysts lower loadings favoring researchers pay attention moreover order make possible comparison results coming different research groups recommend reasonable loading ranges type catalyst elsevier rights reserved
thermal printing papers analyzed contained taking hold receipt consisting thermal printing paper roughly transferred middle finger skin rather dry ten times fingers wet amount transferred dry skin neither significantly increased taking hold paper sites reduced free paper contacted afterwards min applied skin solution ethanol partially longer ethanol whereas transferred skin holding thermal paper remained largely suggests penetration skin depends conditions experiments enable conclude whether passes skin indicated enter skin depth longer ends human metabolism exposure person repeatedly thermal paper day register reach day times less present daily intake however just finger contact containing paper hand cream enhances permeability skin margin smaller
nature one dimensional structure good conductivity excellent transport property single walled carbon nanotubes considered important building new generation electrical circuits article mainly focus two strategies developed installing diverse functionalities single walled carbon based molecular transistors method surface chemical modification overcome defined contacts molecules electrodes highlight current effort direction creation reliable single molecule devices using carboxylic acid functionalized single walled carbon nanotubes point contacts contacts made high resolution electron beam oxygen plasma oxidative electrically functional molecules covalently robust linkages thus forming stable molecular electronic devices results open new opportunities develop unique single molecule biosensors high selectivity high speed hold great promise industrial applications basic scientific researches
light user guided interactive evolutionary system design allows architects use color specify desired light levels spaces searches solutions bring building geometry materials close performance targets proposed interface addresses main limitation generative design systems based building performance metrics allowing user specify daylight spatial patterns high degree granularity development poses new challenges objective function penalty function definitions light automatically computes displays statistical indexes inform user deviation error performance solution found system desired targets system implemented python top popular computer aided design software add visual programming language choice implementation allows access built functions methods parametric modeling tools provide direct access lighting simulation software different types genetic algorithms five experiments conducted parametric model progressive system calibration four steps adjustment targets fit problem feasible solution space devise appropriate weights penalty factors fitness function test two different evolutionary solvers test systems capability find predefined solution optimal values known calibration system able produce solutions closely approximate goals elsevier ltd rights reserved
introduction development monoclonal antibody based biologics targeted inhibition cytokines represent potentially effective treatments patients glucocorticoid refractory eosinophilic asthma covered asthma exhibits marked heterogeneity clinically molecular phenotypic level requiring specifically targeted treatments block key pathways disease becoming apparent significant clinical effects anti cytokine based biologic therapies likely carefully selected patient populations take asthma phenotypes account development reproducible straightforward biomarkers aid identification patients likely benefit treatment expensive interventions narrative review based english language original articles pubmed med line reported significant clinical findings published last two years evidence demonstrating effectiveness otherwise targeting carefully selected patients severe refractory commentary use baseline peripheral blood simple reproducible biomarker identify patients particular sub phenotypes asthma guide effective use biologic therapy represents significant step forward
background hiv aids considered chronic disease quality life qol become important focus researchers healthcare providers technology mediated interventions demonstrated improved clinical effectiveness outcomes viral suppression persons living hiv aids however evidence support impact interventions qol lacking objectives aim paper assess impact technology mediated interventions qol identify instruments used measure qol methods review followed prisma guidelines literature search conducted pubmed cinahl cochrane embase databases april inclusion criteria limited articles technology mediated interventions compared usual care articles population defined hiv infected patients articles qol measured health outcome randomized controlled trials cochrane collaboration risk bias tool used assess study quality results peer reviewed articles returned searches met inclusion criteria systematic review identified four types technology mediated interventions two types qol instruments used examine impact technology mediated interventions four studies technology mediated interventions resulted improvement qol four studies considered qol secondary outcome resulted negative neutral impact qol overall four studies low risk bias one study moderate risk bias five studies high risk bias conclusions evidence support improvement qol using technology mediated interventions insufficient lack research highlights need increased study qol outcome measure need consistent measures better understand role technology mediated interventions improving qol
single inductor multiple output switching power converter architecture cost effective alternative multiple individual switching power converters solution many power distribution system applications multiple voltage required reduced cost however multiple output voltage coupled switching node power converters suffer cross regulation multiple outputs closed loop controller design converter regulation performance paper power control scheme proposed aiming completely operations multiple outputs one another proposed control scheme results eliminating cross regulation among multiple outputs maintaining desired voltage regulation performance output steady state dynamic operations low cost microcontroller analog used implement proposed controller experimental proof concept prototype results verify feasibility advantages proposed controller
subunit vaccines prevention congenital cytomegalovirus infection based glycoprotein clinical trials unclear whether simultaneous vaccination antigens enhances protection undertook evaluation novel vaccine based lymphocytic virus vectors expressing cytoplasmic tail full length human mice immunization vector alone elicited comparable binding antibody response superior neutralizing response elicited subunit immunization vector alone elicited robust cell responses comparable immunogenicity combined vectors individual formulations demonstrated demonstrate proof principle based vaccine congenital guinea pig cytomegalovirus infection model used compare vectors encoding alone combination versus recombinant vectors elicited significant immune responses loss immunogenicity noted formulation combined vaccination conferred better protection maternal subunit either vaccine vaccine also significantly effective reducing mortality vaccines summary vaccines vectors expressing elicited potent humoral cellular responses conferred protection model clinical trials vaccines warranted
overwhelming majority vegetable oils extracted using solvent extraction widely used solvent however use ethanol attractive advantages including low toxicity good operational security obtained source study multiple batch solid liquid extraction system successfully employed simulate continuous extraction rice oil results showed extraction process using ethanol solvent feasible facilitated increases temperature number equilibrium stages required rice oil extraction theoretically determined shown extraction process using number ideal stages lower number required ethanol used solvent furthermore mathematical expression determining minimum flow solvent depending equilibrium relationship extract phases developed implemented solvents given potential fire hazard harmful emissions risks using solvent extraction ethanol showed promising alternative conventional extraction completely solid matrix five stages elsevier ltd rights reserved
skin become emerging area research interest covers wide range applications product design surgery animation materials engineering based literatures rubber one best candidate materials exhibit desirable skin characteristics thus making right material skin substitute nonetheless specific standard used measure mechanical properties deformation behaviour synthetic skin paper first time aims assess two standard testing methods rubber work carried stages involving testing quantifying material constants using matlab programme mechanical tests conducted types materials different grades rubber using tensile test two different standards raw testing data load extension input house developed matlab programme compute plot stress value based neo model based statistical analysis testing data found valid since sample variance found less neo constants found material material revealing difference material material respectively conclusion significant difference quantified material constants suggests dedicated testing standard used
term spondyloarthritis spa used describe group inflammatory autoimmune diseases including ankylosing spondylitis psoriatic arthritis common genetic risk factors clinical features spa clinically distinct rheumatoid arthritis typically affects spine joints less commonly peripheral joints although pathogenesis spa fully understood recent findings identified interleukin pathway key mediator disease pathogenesis clinical evidence efficacy inhibition biologic agents initially shown patients chronic plaque psoriasis another autoimmune disease mediated pathway subsequently similar positive efficacy inhibition seen patients ankylosing spondylitis psoriatic arthritis inhibition also improve cardiovascular metabolic comorbidities often found patients spa studies linked disorders pathway review examine key preclinical studies demonstrated mechanistic role development spa discuss observations translated clinical practice
aims aim study analyze whether parameters helpful diagnosing overactive bladder oab working hypothesis flow curves patients oab symptoms appear sharp peak flow rate short duration high amplitude lasting short period urgency sensation followed reduced urine flow introduced new parameter called flow index defined average divided maximal urine flow rates potential marker diagnosing oab methods conducted retrospective study analyzing urodynamic studies performed women lower urinary tract symptoms based subjective clinical symptoms patients divided four groups pure oab mixed urinary incontinence predominant oab oab mixed urinary incontinence predominant pure patients results comparing pure oab pure patients strong statistically significant difference found mean respectively similar results found comparing patients pure oab oab versus patients pure mean respectively conclusions used additional marker oab diagnosis wiley periodicals inc
specialized structures located fused hard however number arrangement direction differ among species since first animals show fusion authors focused structure surface structure postnatal days examined scanning electron microscopy addition histological observation made hematoxylin eosin staining moreover urea silver nitrate method used nerve staining many like small shaped projections width height observed although projections distributed whole difference density region anterior middle posterior portion hard projections consisted stratified squamous epithelium connective tissue particular many collagen fibers observed connective tissue nerve fibers connective tissue toward oral epithelium collagen fibers sparse area nerve fibers epithelium projections generally known many nerve fibers nerve located connective tissue since many nerve fibers connective tissue projections suggested projections act sensitive organs
high frequency surface wave radar vital military significance continuous surveillance activities within exclusive economic zone however lower spatial temporal resolutions received signals strongly polluted different background noise therefore ship target detection become challenging task letter presents automatic ship target detection algorithm based discrete wavelet transform first peak signal noise ratio based algorithm proposed automatically determine optimal scale extraction ship targets second high frequency coefficients optimal scale processed fuzzy set based method enhance useful target information unwanted background noises third target highlighted image reconstructed ignoring low frequency coefficients performing inverse enhanced high frequency coefficients finally targets extracted adaptive threshold segmentation final target highlighted image experimental results show proposed approach automatically extract ship targets effectively range doppler images complex background better target detection performance previous wavelet based algorithm thereby providing new reliable image processing based method ship target detection
paper methodology estimating regression model locally stationary errors proposed particular consider models two features time varying trends errors belonging class locally stationary processes proposed procedure provides efficient methodology estimating predicting handling missing values non stationary processes consider truncated infinite dimensional state space representation kalman filter algorithm estimate parameters model suggested monte carlo simulation studies performance kalman filter approach good even small sample sizes finally proposed methodology used two real life applications elsevier rights reserved
limitations standard culture techniques development new recombinant protein expression systems biotechnological potential key challenge ideally systems able effectively accurately synthesize protein interest intrinsic metabolic capacity describe system designed based plasmid vector containing promoter elements derived promoter processing purification elements promoter induced heavy metals culture medium induce synthesis human prostate specific antigen modified insert elements purification secretion optimized production system comparing effects contributions hela cells also compared effectiveness three different transfection agents multi walled carbon nanotubes reagent production confirmed via detection enhanced green fluorescent protein fluorescence cell viability determined expression compared native protein produced cells using enzyme linked immunosorbent assay sodium sulfate polyacrylamide gel electrophoresis reagent cell line showed highest production rates furthermore cells resistant oxidative stress caused results suggest proposed optimized inducible expression system effectively produce recombinant proteins desired characteristics wide range applications molecular biology
availability medical imaging data clinical research literature clinical coupled recent advances computer vision offer opportunity image based diagnosis teaching biomedical research however content semantics image vary depending modality identification image modality important preliminary step key challenge automatically classifying modality medical image due visual characteristics different modalities visually distinct others subtle differences challenge variations appearance images based diseases depicted lack sufficient training data modalities paper introduce new method classifying medical images uses ensemble different convolutional neural network cnn architectures state art image classification technique optimal image features given classification task different cnn architectures learn different levels semantic image representation thus ensemble enable higher quality features extracted method develops new feature fine tuning large dataset natural images fine tuning process leverages generic image features natural images fundamental images optimizes variety medical imaging modalities features used train numerous classifiers whose posterior probabilities fused predict modalities images experiments medical image public dataset modalities training images test images show ensemble fine tuned achieves higher accuracy established ensemble also achieves higher accuracy methods literature evaluated benchmark dataset methods source additional training data
objective determine effectiveness teeth prior implant placement improving alveolar bone characteristics implant recipient sites materials methods electronic database searches following databases conducted help senior health sciences medline pubmed embase scopus web science cinahl plus hand searches reference lists selected articles also conducted abstracts appeared fulfill initial selection criteria selected full article retrieval retrieved articles carefully evaluated specific selection criteria applied authors conducted selection processes independently differences resolved discussion analysis timing type magnitude forces applied sought results eighteen articles considered review selected articles case reports case series describing anterior teeth results reported cases evaluated individually collectively regard various hard soft tissue implant site characteristics clinically significant gains alveolar bone tissue reported cases resulting significant quantitative qualitative improvements implant sites conclusions based available literature teeth prior implant placement appears viable alternative conventional surgical procedures implant site development direct comparison method found therefore conclusion made relative efficacy
protective structure material usually natural stone concrete thickness one layer elements elements placed pattern various conditions designing implementing coastal protection structures implementation speed construction cost cause use articulated concrete block appropriate flexibility installed different conditions slope system includes filter layer allows infiltration occur providing particle retention soil determine extent effect hydrodynamic structural non structural factors presenting dimensionless relations design charts experimental data needed achieved appropriate laboratory scale model lambda present study effect various parameters investigated improve existing formula adding effects length construction slope filter layer thickness friction coefficient accordingly new modified equation obtained adding parameters stability shifting factor stability course factor stability shape factor presented approximate respectively end six design charts presented helpful determine minimum length different waves characteristics constructions slope two type filter layer elsevier ltd rights reserved
cellulose electro active paper discovered smart material used sensors actuators flexible electronics made regenerated cellulose requires cellulose pulp using solvents heating process however heating process cellulose critical performance paper introduce new fabrication process cellulose pretreatment process cellulose simplifies fabrication process require heating process pretreatment process includes first immersion cellulose water second immersion solvent followed twice repeat pretreated cellulose dissolved using lithium chloride solvent without heating gives cellulose solution pretreated cellulose solution compared another cellulose solution made solvent heating process terms viscosity solubility cellulose samples made using two cellulose solutions physical electromechanical properties compared terms transparency ion concentration surface morphology youngs modulus dielectric constant piezoelectric charge constant pretreatment cellulose results similar better physical properties simplifies cellulose fabrication
qualitative multiple case study explored sources emotional stress experienced female primary heads leading socio economic disadvantaged schools district attempts alleviate challenges children disadvantaged contexts presented data generated individual semi structured interviews observations data analysed thematically elicit sources emotional labour stress related cultural contextual factors study revealed despite school heads experiencing anxiety pain frustration sadness concern happy leadership positions sources emotional stress related children stereotypical gender expectations lack parental cooperation professional social expectations study suggests wellness establishment social networks heads share experiences professional development programmes stress management possible interventions help heads deal stressful circumstances
family enzymes able catalyze acetyl histone non histone substrates inhibition catalytic activity recently reported literature beneficial human diseases promising applications cancer therapy enzymatic neurodegeneration combining structure based virtual screening database cell based assays identified new scaffold inhibition catalytic activity compound active low range showed optimal physicochemical properties passive absorption relatively low cytotoxicity vitro studies revealed mixed type kinetics toward acetyl lysine substrates nad respectively profile inhibition binding mode consistent experimental evidence proposed molecular modeling additionally levels acetyl shown increased hela cells treated taken together results encourage investigation derivatives related therapeutic effects elsevier rights reserved
automated sensing control system hardware software developed real time spot application granular fertilizer wild fields custom hardware system incorporated commercial pneumatic granular fertilizer custom software sensing control system developed combining color occurrence matrix based texture analysis ratio algorithms acquire process images real time differentiate wild plants bare spots performance accuracy spot applicable fertilizer evaluated laboratory simulation real time field tests simulation results reported accuracy developed system real time field tests reported system produced acceptable results ground speeds spot application fertilizer target areas plant areas within field results also indicated ground speed due images high speed surface wild field spot application fertilizer using modified fertilizer save fertilizer wild producers
various versions typical control panels experimentally analyzed effectiveness efficiency point view stimuli differed objects locations within panel type expected response presented stimuli results users performance investigated using classical analyses variance moreover visual activity examined persons gathered means eye tracking system presented formally analyzed
textile industries major sources environmental water pollution world textile wastewater effluents discharged rivers often appear dark red color due dyes transformed carcinogenic aromatic chemicals used readily degraded nature thus river sediment however little known chemicals affect river sediment river water long persist difficult monitor assess undetectable dyes river sediments evaluated potential river sediment bacteria degrade dyes aromatic describe natural remediation river sediment long contaminated textile effluent cessation wastewater discharge dye degradation potential decreased aromatic amine degradation potential increased initially declined time changes degradation potential consistent changes sediment bacterial community transition occurred order years data strongly suggest dyes remained river sediment aromatic produced even transparent longer colored river water chemicals degraded changing sediment bacteria time course monitoring degradation activities key bacteria thus enables assessment fate dye pollutants river sediments elsevier ltd
due network security situation affected threat degree network attacks significance network services network system situation evaluation values possess uncertainty situation evaluation values real timely demand network security situation improved prediction model based clonal selection system cloud model namely model proposed used predicting time series network security situation model model viewed basic prediction model clonal selection principle used optimizing parameters model order improving prediction precision proposed model experimental results show model accurate model provide effective prediction approach network security situation
current study sought assess acceptability feasibility compassion focused therapy group adjunct evidence based outpatient treatment eating disorders examine preliminary efficacy relative treatment usual tau twenty two outpatients various types eating disorders randomly assigned tau tau plus weekly groups adapted eating disorder population tau participants conditions completed measures self compassion compassion shame eating disorder pathology baseline week week week additionally participants receiving group completed measures assessing acceptability feasibility group results indicated group demonstrated strong acceptability attendance high group retained participants participants rated group positively indicated likely recommend peers similar symptoms intention treat analyses revealed compared tau condition tau condition yielded greater improvements self compassion self compassion receiving compassion shame eating disorder pathology results suggest group based offered conjunction evidence based outpatient tau eating disorders acceptable feasible efficacious intervention furthermore eating disorder patients appear see benefit observe gains working goals overcoming compassion developing self compassion accessing compassion others copyright john wiley sons ltd
paper analyses vehicle dynamics operation drive wheel load parameters vehicle model calculated vehicle force equations validate model speed torque measurements conventional car carried comparison measured simulated values electric motor inverter batteries basis vehicle traction characteristics models internal combustion engine ice gear box electrical drive motor inverter batteries made comparison hybrid conventional drives fuel consumption made
paper introduced self tuning fuzzy pid controller based particle swarm optimization aims gain precise control position pneumatic proportional valve particle swarm works optimize membership function fuzzy rule pid parameter fuzzy control study fruits also include online optimization self tuning fuzzy pid controller parameters comparing conventional control methodology self tuning fuzzy pid controller pso optimization proven show better precision dynamic performance index rapid tracking performance robustness end step response used compare analyze results pso algorithm optimization providing pragmatic method better comprehensive performance pid parameter optimization
preprocessing data transmission recommended many sensor network applications reduce communication improve energy efficiency however constraints memory speed energy currently limit processing capabilities within sensor network paper describe ultra low power analog circuitry integrated sensor nodes create energy efficient sensor networks demonstrate concept present custom analog front end performs spectral analysis fraction power used digital counterpart furthermore show front end combined existing sensor nodes selectively wake based upon spectral content signal thus increasing battery life without missing interesting events achieve low power signal analysis using analog spectral decomposition block digital computation resources higher level analysis experiments context vehicle classification show improved performance asp digital implementation
wind turbine system configured three level neutral point back back power converter direct drive train good properties solution high power wind energy applications direct model predictive control emerged viable alternative power electronics electrical drives work presents direct model predictive current control solution grid generator side control grid connected back back power converters wind turbine systems presented realized alpha beta frame evaluated experimental results fully fpga based platform experimental results confirm effectiveness better steady state control performances comparison conventional switching table based technique
model characterizes psychopathy terms three distinct constructs model scales designed specifically index domains using items provide coverage related constructs present study sought develop validate scales assessing model domains using items personality inventory form consensus rating approach used identify items relevant domain following psychometric refinement resulting based scales evaluated convergent discriminant validity relation multiple psychopathy relevant criterion variables samples expected convergent discriminant associations evident clearly scales somewhat less clearly scale moreover hierarchical regression analyses indicated scales standard scale scores predicting extant model scale scores widespread use clinical forensic settings provides avenues clinical research applications contexts traditional psychopathy measures less likely administered
cerebral mri markers attributed common cerebral elderly patients dementia hypertensive cerebral amyloid detection asymptomatic persons help identify risk dementia influence preventive strategies design clinical trials testing treatments dementia studied association risk incident dementia community dwelling individuals total dementia free heart study participants mean age years women available brain mri incident dementia data mean follow period years included using cox proportional hazards models related presence incident dementia multivariable models adjusted age sex apoe status education additional models adjusting vascular risk factors mri markers ischemic brain injury observed incident dementia participants study period participants times higher risk dementia hazard ratio confidence interval whereas deep mixed three fold increased risk associations independent vascular risk factors deep mixed also independent mri markers ischemia purely associated incident dementia findings support role hypertensive interplay hypertensive cerebral amyloid risk dementia suggest presence identify individuals risk dementia elsevier inc rights reserved
modified equation electrical transmission line investigated paper different expressions parameters equation given means hirota method bilinear forms soliton solutions equation obtained linear stability analysis yields instability condition soliton solutions find soliton amplitude becomes larger inductance capacitance decrease phase plane analysis conducted equation properties equilibrium points investigate perturbed equation proposed external periodic force considered weak developed chaotic motions observed results indicate two chaotic motions manipulated certain relation absolute values nonlinear terms perturbed one also find chaotic motions weakened absolute values decreased elsevier ltd rights reserved
myc overexpression implicated several malignancies including gastric cancer report bile acids enhance tumor progression activity gastric cancer via myc activation vivo vitro myc mrna protein levels assessed ten primary five local recurrent gastric cancer samples quantitative real time polymerase chain reaction western blotting analysis gastric cancer cell line exposed bile acid acid daily develop resistant cell line control cells grown without acids bile control cell morphology proliferation colony formation apoptosis resistant cells analyzed determine involvement myc tumor progression telomere aging resistant cells generated mice measured xenograft volume vivo activity myc protein mrna levels significantly higher local recurrent gastric cancer samples primary gastric cancer samples resistant cells showed marked phenotypic change normal growth conditions clusters exhibited increased cell viability colony formation decreased apoptosis vitro phenotypic changes found dependent myc activation using myc inhibitor resistant cells also showed myc dependent increase xenograft growth activity vivo conclusion observations support hypothesis bile acids enhance tumor progression activity gastric cancer effects dependent myc activity findings suggest bile acids play important role malignant progression local recurrent gastric cancer
paper focuses application new learning materials university west faculty mechanical engineering department machine design study materials based injection previously applied practice main advantage learning materials help students become familiar master design issues practical viewpoint learning material written structured unified form following sequence basic information injection given introduction second part student view active two colour models according function machining technology learning materials include drawing documentation main assembly consist manufactured
investigate resonant system resonant system natural dimensional version resonant nonlinear schrodinger equation traveling wave solutions found paper demonstrate effectiveness analytical methods namely improved phi expansion method item generalized expansion method seeking exact solutions via resonant system methods direct concise simple implement compared existing methods exact particular solutions containing four types solutions hyperbolic function trigonometric function exponential solutions obtained solutions comparing methods methods results demonstrate aforementioned methods efficient variable separation method applied chaos solitons recently item developed searching exact traveling wave solutions nonlinear partial differential equations abundant exact traveling wave solutions including solitons periodic rational solutions found solutions play important role engineering physics fields shown methods help symbolic computation provide straightforward powerful mathematical tool solving nonlinear problems
paper focuses design experimental test results belt driven generator mini hybrid functionalities required system engine launch torque regenerative braking battery charging early fuel cutoff cost effective electrical machine provide high starting torque wide constant power speed range motor generator modes authors outline motivations electrical machine topology selection relation specifications constraints particular double three phase induction machine selected suitable candidate aim paper summarize design challenges kind electrical machines mainly electromechanical thermal issues imposed considered hybridization solution details machine design presented including study multilayer bar stator windings rotor slot design finally predicted measured performances prototype reported discussed validation purposes
luts associated obesity hypogonadism metabolic syndrome mets mets induced prostate bladder alterations including inflammation tissue remodeling related low testosterone high estrogen milieu addition able mediate several non genomic actions subgroup mets rabbits analyzed vivo effects mets induced prostate bladder alterations effects selective ligands silencing prostate inflammation also studied vitro using cells expression upregulated mets bladder decreased expression stimulating addition dosing decreased mets induced overexpression inflammatory tissue remodeling genes prostate sex steroid receptors pro inflammatory pro fibrotic genes upregulated mets however affect even increased cox cells estradiol increased secretion effect blunted treatment antagonist antagonist increased agonist dose dependently induced secretion vitro analysis demonstrated silencing effects considered main mediator estrogen action prostate whereas bladder mechanism appears rely indicated vivo experiments dosing limiting effects mets induced estrogen action via offer new perspectives management luts whereas dosing showed potential benefits bladder prostate wiley periodicals inc
mitochondria oxidative phosphorylation system aerobic conditions produces bulk cellular adenosine atp mitochondrial genome encodes key components system transcribed mitochondrial rna polymerase levels mitochondrial transcription correlate respiratory activity cell therefore compounds increase decrease mitochondrial gene transcription useful fine tuning metabolism used treat metabolic diseases certain forms cancer report establishment novel high throughput assay technology allowed screen library diverse compounds effects mitochondrial transcription vitro following secondary screens facilitated assay principle identified compounds efficiently selectively inhibit mitochondrial transcription active also cell culture method easily adaptable rna dna varying spectroscopic detection technologies
many biological studies proposed human papillomavirus hpv primarily high risk etiological factor subset head neck cancers premise systematically reviewed relevant articles improved understanding hpv related cancers article comprehensively described characteristics hpv associated tumors according histopathology molecular biology prognosis meta analyses conducted combine studies reported association hpv status variables using man pooled results showed hpv positive tumors poorly differentiated smaller also strongly associated node involvement hpv related tumors showed significantly overexpression less mutations hpv negative tumors patients hpv positive cancers different clinical behaviors reduced risks death study supported view point hpv favorable indicator prognosis hpv related tumors distinct traditional tumors etiological relationship impact future strategies diagnosis prevention therapy prognosis subset patients wiley periodicals inc
widely consumed many parts world dietary intake associated cancer risk reduction extracts metabolites derived vegetables thus gained popularity potential cancer agents previously found extensively present vegetables potent phase enzyme inducer present study influence black seed extract rich investigated phase enzymes different organs male female rats oral seed extract injection one four consecutive days significantly affected various cytochrome cyp linked complex way lung responsive organ males similar increase isoform similar loss findings indicate extract strongly enhance suppress rat pathways caution paid possible influence human metabolism data suggest overall evaluation balance beneficial possible adverse effects agent even natural origin prior routinely preventive mass use elsevier ltd rights reserved
effectiveness treatment individuals diagnosed antisocial personality disorder aspd questioned debated years individuals aspd considerably criminal justice system ability treatment reduce prominent concern present meta analysis identified six unique controlled uncontrolled treatment outcome studies investigating effectiveness treatment reducing general individuals aspd results controlled studies indicated significant differences rates individuals aspd treatment treatment usual however direction odds ratios suggested lower treatment groups results uncontrolled studies suggested equal effectiveness treatment comparing individuals without aspd however effects attributable treatment question interpretation findings generalizability general treatment literature individuals aspd discussed
practice teaching important part ideological political theory course colleges universities realization ideological political education purposes function meaning theory teaching however practice teaching education ideological political theory colleges universities however many problem notes allow ignore know team construction management guarantee mechanism four aspects strengthen strengthen ideological political theory class practice teaching effectiveness
use convex gained considerable interest power systems play major role providing quality guarantees non convex optimization problems optimal power flow problem programming relaxation known produce tight lower bounds unfortunately solvers still suffer lack scalability work introduce exact relaxation formed set polynomial constraints defined space real variables new constraints seen strengthening weaker second order cone generated iterative fashion new formulation handled standard nonlinear programming solvers better stability computational efficiency new approach benefits recent results tree decomposition methods reducing dimension underlying matrices side result present formulation kirchhoffs voltage law space reveal existing link cycle constraints original relaxation three dimensional matrices preliminary results show significant gain computational efficiency compared standard solver approach
partial progesterone estrogen receptor antagonist functioning actively progesterone receptor gene associated transcription reason used contraceptive agent present study cellular gene specific effects investigated rat model early pregnancy including key phases window early implantation stages regulated progesterone estrogens focus elucidate mechanism action single dose used contraceptive successfully prevent implantation viable techniques used examine change protein levels treated days pregnancy changes gene expression level consequence administration evaluated using quantitative real time reverse transcription polymerase chain reaction progesterone receptor gene protein expression ubiquitously decreased throughout pregnancy direct consequence administration overall effects administration early pregnancy indicate highly effective inhibition progesterone estrogen effects mediated receptors specifically expression localization progesterone receptor described ovariectomized animal models suggesting stimulated clearly present study precise priming progesterone preparation implantation severely impaired thus predisposing uterus pregnancy failure society biology reproduction institute animal reproduction food research polish academy sciences published elsevier urban partner rights reserved
discovery characterization micrornas mirnas families short rnas led rapid expansion research directed elucidating expression patterns regulatory functions describe convenient sensitive straightforward method detect specific mirna levels total rna samples method based ligation require specialized equipment amplification step significantly faster sensitive northern blotting demonstrate method used detect various classes small regulatory rnas different organisms
present paper details development cost effective fall detection intervention system based wireless sensor network technologies system designed integrate existing low homes enable ambient assisted living environments software hardware devices attempt facilitate safe proactive independent living designed operate add component existing centralized solutions complete otherwise integral yet independent component decentralized scalable solutions accordingly implemented two parts part developed scaled proof concept served foundation part principal focus paper part developed fully operational real scale system uses self healing mesh network protocol black development platform serves sink node two class degrees line used conjunction light dependent resistors gauge probabilities emergency event based estimated dimensions object parts probabilities emergency event high series corresponding robotic response actions intervene locally automated sent emergency personnel care family members via wireless cellular technologies series sample runs detailed described present work order demonstrate argue feasibility functionality fall detection intervention system particular wsn based system general elsevier rights reserved
prediction problem network security studied facing massive malicious attacks information time network security ensured network security situation prediction necessary ensure safety network therefore markov game theory applied predicting network security situation firstly network security situation prediction model constructed based coarse grained treatment secondly prediction model network security situation based markov game theory established basic procedure network security situation prediction established finally simulation network security situation based markov game carried results show markov game theory effective method predicting network security situation
objectives little known consequences adolescent social media use current study estimated association amount time adolescents spend social media risk episodic heavy drinking methods school based self report cross sectional study including norwegian middle high school students boys measures frequency quantity social media use frequency drinking four six girls boys respectively alcoholic single day episodic heavy drinking scale subjective social status scale brief brief sensation seeking scale patient health questionnaire items adolescents strengths difficulties questionnaire peer relationship problems scale gender school grade results greater amount time spent social media associated greater likelihood episodic heavy drinking among adolescents even adjusting school grade impulsivity sensation seeking symptoms depression peer relationship problems conclusion results current study indicate time spent social media related greater likelihood episodic heavy drinking among adolescents
review paper recent advancements multidimensional spatio temporal signal processing highly directional radio frequency antenna array based receivers discussed network resonant filters infinite impulse response recursive spatio temporal signal flow graphs reviewed concept network resonant pre filtering described modification existing timed array back ends achieve improved side lobe performance array pattern leading better interference rejection capabilities digital analog signal processing models described terms system transfer functions signal flow graphs example frequency response antenna array pattern simulations presented
purpose review exacerbations major impact quality life healthcare costs long term risk complications preventing exacerbations one major goals treatment increasingly recognized impact exacerbations daily clinical practice also increasing recent findings preventing exacerbations dependent appropriate risk assessment identifying patients highest risk target preventive therapies inhaled oral antibiotic treatments target chronic bacterial infection one major risk factors exacerbation although data weak airway clearance important part long term management including patients frequent exacerbations anti inflammatory therapies inhaled corticosteroids currently major role outside comorbid chronic obstructive pulmonary disease asthma studies required summary treatment acute exacerbations involves prompt administration antibiotic therapy usually days oral severe exacerbations intravenous antibiotics role corticosteroids established little data optimal management approach acute exacerbations home intravenous therapy reduce healthcare costs improve patient satisfaction care number large randomized controlled trials currently recently completed raising possibility treatment paradigm change near future
development signaling pathway regulates key physiological processes control organ size regeneration stem cell biology yes associated protein major transcriptional activator pathway scaffold protein interacts binding partners integrate diverse signaling pathways study report binds modulates activity cells vitro analysis pure proteins demonstrated direct interaction analysis multiple fragments protein showed interaction occurs via domain binding domain interaction functional effects knock endogenous significantly increased formation nuclear complexes transcription assays performed null mouse embryonic fibroblasts cells knockdown quantification demonstrated mediated transcription cells lacking significantly greater control cells data reveal binds modulates transcriptional function suggesting participates signaling
insulin producing beta cells pancreatic coupled channels investigate controls expression investigated pattern mouse pancreas development influence three transcription factors critical beta cell development differentiation show gene activated early pancreas development markedly induced time surge transcription factors determine beta cell differentiation protein detected week later selectively expressed beta cells throughout prenatal development mouse pancreas fragment promoter contains three boxes binding factor ensures expression beta cells binds boxes presence ubiquitous cofactor promoter data identify novel early marker beta cells target essential beta cell development differentiation
psoriasis chronic autoimmune inflammatory disorder impacts skin joints propensity produce devastating psychosocial economic occupational effects often solitary example psychological manifestations impact ones occupational economic purpose raise awareness consequences disease clinicians consider incorporating patient centered model care
now exists interest role metabolism medicine especially relation medical disorders coupled contemporary focus molecular biology genetics proteomics integration studies regulation alterations cellular metabolism health disease marriage vast potential elucidation factors conditions involved cellular metabolic functional changes addressed earlier generations established major pathways metabolism achievement present potential requires appropriate application interpretation genetic proteomic studies relating cell metabolism cell function requires knowledge understanding principles relationships methodology biochemistry enzymology involved elucidation cellular regulatory enzymes metabolic pathways unfortunately many possibly contemporary molecular adequately trained areas cell metabolism resulted much common inappropriate application misinformation genetic proteomic studies cell metabolism function presentation describes important relationships cellular metabolism provides examples appropriate inappropriate application genetics proteomics calls inclusion biochemistry enzymology cell metabolism cell physiology graduate training molecular biology biomedical researchers elsevier rights reserved
two stage large capacitive load amplifier multiple cross coupled small gain stages proposed paper cross coupled structure small gain stages large signal responses providing significant improvement effective output stage transconductance hence gain bandwidth product implemented standard cmos technology powered supply current consumption proposed amplifier achieves mhz phase margin degrees driving capacitive load average slew rate chip compensation capacitor active chip area
background several studies show association eczema attention deficit hyperactivity disorder adhd childhood mechanisms time sequence remain unclear information association eczema disorders involving central nervous system cns limited aim explore whether preschool eczema associated adhd cns associated disorders requiring pharmacotherapy school age analyze whether eczema ages childhood associated medication adhd methods swedish birth cohort children included analyses years age parents answered questionnaires regarding eczema last year information prescribed medications school age years age derived record linkage swedish prescribed drug register results total children preschool eczema eczema years children adhd medication school age preschool eczema associated adhd medication school age crude odds ratio confidence intervals significant association preschool eczema use antidepressants migraine drugs anti school age eczema school age eczema eczema ever years age associated adhd medication school age conclusions large birth cohort significant associations preschool eczema medications adhd depression anxiety migraine epilepsy school age
individuals trait display poor cognitive assimilation thoughts feelings emotions result persistence stress anxiety depressive disorders cumulative effect psychological distress also linked clinical markers human immunodeficiency virus hiv disease progression study examines indirect effect hiv viral load function baseline levels change psychological distress hiv positive adults aged years provided blood samples hiv viral rna lymphocytes along self reported stress anxiety depression every months years second order conditional latent growth model used represent baseline year change cumulative levels psychological distress test indirect effect baseline levels trait change hiv viral load latent measure associated baseline latent change psychological distress furthermore baseline psychological distress predicted year change hiv viral rna controlling viral load baseline altogether trait significant indirect effect change viral load beta function baseline levels distress identification communication thoughts feelings emotions important long term psychological adaptation hiv greater psychological distress turn allows persistence peripheral viral replication
paper presents upcoming method searching optimal placement measurement units power system state estimation proposed technique based technology allows estimate current status electrical network reliable accurate way fact looking full system observability take account lack availability appropriate data network nodes intervention renewable energy sources investigations facts systems extended enhance smart grid performances stability experimentally application efficient placement strategies help allocate critically bus test system
study determine role mechanism rheumatoid arthritis totally wistar rats randomly divided control group model group methotrexate group high dose middle dose low dose groups swelling degree arthritis score thymus spleen index mrna protein levels inos serum content tnf evaluated treatment significantly alleviated swelling rats arthritis score treatment groups significantly lower model group additionally thymus index spleen index declined remarkably treatment groups model group besides administration significantly reduced inos production serum content tnf exert potent anti effects inhibiting cytokine
authors examined association maternal childhood abuse frequency providing social support mothers victim adult investigated mediating effects internal working models self esteem positive relations others maladaptive coping using data national survey development united states analyzed sample adult children using structural equation modeling approach results showed maternal childhood abuse associated providing less frequent emotional support mothers although authors find significant mediating effects internal working models maladaptive coping association child abuse intergenerational support giving findings suggest implications theory practice policy address specific concerns possible challenges adults history childhood abuse experience relationship mothers
new pharmaceutical form results impressive amount waste due methods used despite numerous reports addition pharmaceutical ingredients environment effect environment level remains largely unknown thus proposed retain toxic compounds using tablets containing nitrate antifungal medication study demonstrates reduction water pollution using pharmaceutical forms nitrate time proposed method also utilize anti fungal substances recovering ion changing pollutant examined study nitrate resin represented pharmaceutical form water resulting solution filtered resin chemical test reports created parameters registered values wastewater limits ionic exchange method study anion nitrate ended waste preparation new pharmaceutical forms antifungal effect retained anion nitrate percentage confirmed different nitrate tablets water
production chain high energy water intensive low resource efficiency paper focus characterizing potential environmental improvement production chain promoting optimization technology implementation rainwater harvesting rwh material recovery sludge environmental performance multi blade multi wire saw technologies compared mean life cycle assessment results demonstrate technology contribute water savings energy savings material savings per square meter production resource savings contribute together reduce products environmental footprint potential rwh analyzed using simulation software based system dynamics rwh depends relationship rainfall catchment surface tank size according industrial water demand results demonstrate major potential satisfy system daily water requirements using rainwater stored rainwater tanks varying capacity rwh sustainable strategy industrial water cycle management comprehensive review literature reveals range technically feasible alternatives promote material recovery sludge ceramic industry one promising industrial endpoint avoid waste contribute mineral energy water savings product synergy also serve starting point exchanges industrial agents becoming global extension resource efficiency elsevier ltd rights reserved
current approaches visual inertial able attain highly accurate state estimation via nonlinear optimization however real time optimization quickly becomes trajectory grows time problem emphasized fact inertial measurements come high rate hence leading fast growth number variables optimization paper address issue inertial measurements selected single relative motion constraints first contribution theory properly addresses manifold structure rotation group formally discuss generative measurement model nature rotation noise derive expression maximum state estimator theoretical development enables computation necessary optimization bias correction analytic form second contribution show inertial measurement unit model seamlessly integrated visual inertial pipeline framework factor graphs enables application incremental smoothing algorithms use model visual measurements avoids optimizing points accelerating computation perform extensive evaluation pipeline real simulated datasets results confirm modeling effort leads accurate state estimation real time state art approaches
background objective assess prevalence hypertension diabetes subjects subclinical hypothyroidism comparison age sex matched control group patients methods case control study subjects controls carried patients aged years admitted primary care centre prevalence hypertension diabetes blood pressure plasma glucose lipid evaluated groups results differences observed neither prevalence hypertension diabetes mean values blood pressure plasma fasting glucose subjects increased prevalence lipid abnormalities increased mean values total cholesterol compared control group conclusion patients increased prevalence lipid abnormalities responsible increased cardiovascular risk patients elsevier espana slu rights reserved
gray water recycling economical use rainwater valuable alternative source water especially non potable uses sources seen basis change waters management gives possibility protection still water resources taking account continuing urbanization population growth world management water resources requires change attitudes also management conservation conventional fuels energy generated required development functioning urban areas bearing mind studies performed order establish cost effectiveness application systems capable reducing demand tap water electricity used heat financial analysis application life cycle cost methodology conducted multi family residential building seven different variants installation water sewage assumed use following solutions gray water harvesting system rainwater harvesting system drain water heat recovery units analysis showed use systems tested building viable despite fact implementation associated higher investment cost base case variant study expanded sensitivity analysis basis possible conclude project involving use alternative sources water energy building slightly susceptible changes calculation parameters elsevier rights reserved
inflammatory bowel disease periodontitis described disproportionate mucosal inflammatory response microbial environment susceptible patients moreover two conditions share major environmental lifestyle related risk factors despite intriguing pathogenic parallel large scale studies basic research recently considered periodontal outcomes relevant data mounting consistent arguments recent epidemiologic studies animal models two conditions related article comprehensive critical date review current evidence future prospects understanding biologic epidemiologic relationships periodontal status inflammatory bowel disease
segmentation classification objects images one important yet one complex problems computer vision work propose new model natural image object classification using contextual information level image segments context modeling largely independent appearance based classification proposed model enables simple upgrade existing systems information global local context context modeling based non parametric use appearance based classification results novel approach compared previous systems model context limited number rules expressed fixed set parameters model implementation resulted system simulations showed stable improvement appearance based object classification
cross sectional thin walled circular steel tube large plastic bending also known effect usually occurs initial stage tubes continuous rotary process maximal cross section important technical parameter tubes process control tubes bending deformation prevent however lack special analytical model determined accordance specified charts developed experienced operators basis experimental data thus inevitable local occur actual operation present paper simplified normal strain component formulas derived based thin theory strain energy thin walled tube per unit length obtained subsequently using elastic plastic theory finally rational model predicting maximal section thin walled circular steel tube process presented principle minimum potential energy simplified model validated experiments numerical simulations results show model experiments numerical simulations less error new model expected find potential application thin walled steel tube machine design elsevier rights reserved
parkinsons disease neurodegenerative disorder accompanied various non motor symptoms including depression anxiety precede onset motor symptoms irreversible monoamine oxidase inhibitor widely used treatment major depression however reports effects non motor symptoms aim study explore antidepressant effects using knockout mouse related genetic model displaying depression anxiety compared drugs antidepressant investigate effects biochemical parameters emotion related brain regions single administration dose dependently reduced immobility time forced swimming test mice wild type mice significantly increased time mice single administration drugs dopamine receptor agonist another inhibitor repeated injections specific serotonergic antidepressant also decreased immobility time increase time mice antidepressant like effects comparable tended stronger mice showed decreases striatal hippocampal serotonin content cortical content plasma concentration single administration returned striatal cortical plasma levels observed mice open field test repeated administration effects ameliorated anxiety like behaviors mice social interaction preference tests repeated ameliorated high anxiety low mice whereas results indicate antidepressant mild effects mice suggest effective drug depressive anxiety symptoms patients single nucleotide polymorphism snp
introduction considering estradiol polyunsaturated fatty acids roles neurotransmission examined whether association incident depressive symptoms postmenopausal women modified hormone therapy use estrogen status methods women free depressive symptoms baseline multi ethnic study atherosclerosis classified usage dietary acid epa acid dha sum epa dha women serum taking antidepressant first function use second function low status results among non users positive graded relationships trends found incident depressive symptoms compared lowest quartile adjusted risk ratios highest epa dha epa dha respectively users associations seen analyses run status positive graded low women null high women conclusions higher intakes dha epa associated higher risk depressive symptoms contrary hypothesis elsevier ltd rights reserved
background non celiac wheat sensitivity new clinical entity world gluten related diseases nickel frequent cause contact allergy found wheat results systemic nickel allergy syndrome mimics irritable bowel syndrome ibs objective evaluate frequency contact dermatitis due nickel allergy patients diagnosed double blind placebo controlled challenge identify characteristics patients nickel allergy methods performed prospective study patients females males mean age years diagnosed december november age sex matched subjects functional gastrointestinal symptoms served controls patients reporting contact dermatitis related nickel containing objects underwent nickel patch test registration number results six sixty patients suffered contact dermatitis nickel allergy frequency statistically higher observed control group main clinical characteristic patients nickel allergy higher frequency cutaneous symptoms wheat ingestion compared patients suffer nickel allergy conclusions contact dermatitis nickel allergy frequent patients subjects functional gastrointestinal disorders furthermore patients high frequency cutaneous manifestations wheat ingestion nickel allergy evaluated patients cutaneous manifestations wheat ingestion
year old male patient permanent testosterone therapy hypogonadism presented abdominal pain increased blood pressure values physical examination plethora noted laboratory examinations revealed subsequent diagnostic process polycythemia vera cancer excluded cause secondary due testosterone substitution diagnosed high testosterone levels represent rare cause secondary appropriate medical history taken account early stage
death devastating involved year critically neonates present emergency departments across united states infants require acute medical interventions goal stabilization despite efforts hundreds infants die every year emergency departments across united states emergency care providers providing neonatal end life care feel best care families measures neonates die literature suggest increased knowledge advance preparation providers caring patients situations aim provide article broad overview variety topics related neonatal death care
propose novel design optical buffer generate slow light based delay time framework nonlinear investigate propagation solitons dynamical control slow light solitons realized via controlling fields generated bright soliton gaussian pulse nonlinear dependence velocity signal controlling field analytically described buffering effect achieved slowing optical signal using external control light source vary dispersion characteristic medium via graphical approach signal flow graph method used derive optical transfer functions domain filters characteristics optical buffer devices including time delay drop port simulated simulated results show criteria achieving slow light semiconductor finally output signal shows delay time rate propagation semiconductor society photo optical instrumentation engineers spie doi
autism related disorders increasingly prevalent behavioral syndromes impaired verbal nonverbal communication socialization owing neurodevelopmental abnormalities recent estimate prevalence autistic disorders global scale etiology autism multifactorial multidimensional makes therapeutic intervention even heterogeneity genetic factors oxidative stress autoimmune mechanism epigenetic mechanisms complicate nature pathogenesis disease approach treat disease promising strategy especially areas attractive others review critically analyzes roles vitamins dietary modifications gut abnormalities probiotics environmental factors order determine state evidence based autism management practices article presents systematic review randomized trials examine evidence supports use autism results discussed light relevant evidence generated clinical exploratory studies university production hosting elsevier rights reserved
long noncoding rnas play crucial roles carcinogenesis however function mechanism human non small cell lung cancer nsclc still remaining largely unknown long noncoding rna found upregulated acts oncogene breast cancer little known expression pattern biological function underlying mechanism nsclc herein identified oncogenic driving tumorigenesis nsclc found upregulated associated tumor size metastasis poor prognosis nsclc moreover affected cell proliferation metastasis apoptosis multiple nsclc cell lines mechanistically bound histone methyltransferase enhancer homolog catalytic subunit complex highly conserved protein complex regulates gene expression lysine histone acted modular scaffold complexes coordinated localization specified histone modification pattern target genes including consequently altered nsclc cell biology thus mechanistically functionally clinically oncogenic nsclc targeting pathway meaningful treating patients nsclc
antimicrobial peptides central effector molecules skin immunology functions antimicrobial peptides skin diseases include ability act cytokines growth factors driving disorders psoriasis action natural antibiotics control bacteria influence diseases atopic dermatitis
traditional power control schemes induction heating device mainly focus pulse frequency modulation pulse density modulation solve problems power control efficiency load paper presents analyzes frequency modulation control scheme used full bridge series resonant inverter proposed control technique output power controlled two variables operation frequency division factor better efficiency performance achieved medium low output power range compared principles zero voltage switching condition explained power losses switches analyzed control algorithm schedules three control modes experimentally verified digital signal processor based induction heating prototype load noise thermal distribution problem switches also analyzed
background hepatitis occurs developed countries consumption containing hepatitis virus genotype hev hev major risk factor infection serological diagnostic kits currently used hospitals sometimes produce false negative positive results therefore detection hev rna antibodies virus required diagnosis hepatitis objectives aimed detect hev serum samples patients hepatitis determine origin hev study design nested polymerase chain reaction pcr method developed detection hev hev patients hepatitis total serum samples deposited patients acute hepatitis negative hepatitis examined using method amplified pcr products genetically analyzed results four hev isolates detected serum samples phylogenetic analysis indicated three four isolates closely related hev isolates found pigs korea patients hepatitis japan conclusions newly developed nested pcr method useful detection hev patients hepatitis close relationship human hev isolates identified study isolates implied transmission hev source infection patients hepatitis elsevier rights reserved
objective three aims report first describe research evidence informed service development rationale new eating disorder service people aged years older second examine profile people accessing first years operation respect three broad dimensions illness stage illness severity previous history treatment finally examine patient characteristics resulted recommendation ongoing treatment contact method year period july july people referred service data used research results half referrals related anorexia nervosa split bulimia nervosa specified feeding eating disorders previously received treatment eating disorder initial information service typically provided general practitioner primary care physician compared eating disorder diagnosis people three times likely recommended retain treatment contact discussion service development informed research evidence clinical expertise consideration patients characteristics values circumstances allows flexible development strategy
quite challenge remember store key secret image moreover encrypted image suspicion paper novel secret image sharing scheme additional capabilities proposed using bit plane compression interpolation formula proposal suggests user select image example famous character image cover image secret image enhance security specifically protected image divided three shares hidden cover image create meaningful shadow images three shadow images distributed three different devices example smartphone cloud storage collecting two shadow images user retrieve original secret image cover image addition proposed scheme easily smartphone lost system analysis shows proposal achieves theoretical information security also technically practical
epstein barr virus ebv primary infection usually asymptomatic sometimes progresses infectious occasionally people develop chronic active ebv infection underlying immunodeficiency belongs continuous spectrum ebv associated disorders ebv heterogeneous clinical presentations high mortality established cell mediated immune response plays critical role disease evolution ebv infection recently high throughput sequencing determining region segments cell receptor cell receptor beta tcr beta emerged sensitive approach assess cell repertoire study fully characterized diversity peripheral blood tcr beta repertoire patients ebv seropositive controls compared healthy ebv seropositive controls patients demonstrate significant decrease peripheral blood tcr beta repertoire diversity basically including repertoire breadth highly expanded clones skewed length distribution however significant difference patients furthermore observed disease related preferences usage combinations lots cell clones shared different groups unique overlapped involved public cell responses provide detailed insights divergent disease evolution
termination development goals gave birth sustainable development goals target provide access safe economical drinking water survey research adopted stratified sampling technique captured households structured questionnaire consisting open closed ended questions distributed questions line water hygiene recommendations drinking water household surveys examined access safe water regarding accessibility availability acceptability ota state nigeria personal interviews conducted capture emotional respondents towards subject matter cross multinomial model used analyze relationship variables water access results obtained showed water access within study area mostly limited private sources level quality accessibility study reveals fate placed government water facilities drastically furthermore study highlighted need revisit government policies inclusion cost recovery rainwater harvesting effective tools improving encouraging equity water access elsevier ltd rights reserved
semiconductor promising approach combat environmental pollution global energy shortage advanced based photocatalysts novel properties benchmark materials pursued high solar energy conversion efficiency among different morphological nanostructures attract attention due unique physical properties ideal like morphology favorable constructing second phase nanoparticles surface large number studies proven designed broaden active light band also enhance light absorption performance photo induced carrier separation ability become versatile powerful tool building high performance based photocatalysts stimulated intense research activities focused growth properties applications review attempts cover aspects including underlying principles key functional features comprehensive way also discuss prospects type novel hybrid photocatalyst elsevier rights reserved
morphological reproductive physiological differences river development fetus weight fetus reported river animals aim study describe inherent variability fetus related measurements pregnancy data based measurements fetuses new born results show significant linear correlation exists estimated age fetuses parameters fetus sizes correlations crown length fetal parameters fetus weight parameters conclusion data indicated feasibility value fetal measures used evaluation fetal development
processes provide convenient framework interest lies transition intensities set defined states however event interest known event occurs occurs future transitions process occurring drawing inference joint event process problematic health studies particular example resolution resolved patient longer experience symptoms explored illustration model includes state space original process state representing absent symptoms latent absorbing resolved state temporary transient state absent symptoms proposed expanded state space explicitly distinguishes resolved temporary absent symptoms states allows uncertainty knowing resolution occurred easily captured constructing likelihood observations absent symptoms considered temporary resulted resolution proposed methodology illustrated psoriatic arthritis data set outcome interest set observed disability scores estimated probabilities resolving also obtained model authors statistics john wiley sons ltd
investigations utilizing recombinant human enzymes human hepatocytes revealed number interactions different environmental chemicals also endogenous metabolites potent inhibitors human metabolism jet fuel components potent irreversible inhibitors testosterone metabolism cytochrome cyp estradiol metabolism cyp believed due release reactive sulfur cyp catalyzed oxidative also shown esterase responsible initial step metabolism human liver inhibited number pesticides including shown cyp isoforms human hepatocytes potent several including show toxicity toward human hepatocytes potent regard alpha shown promise model substrate human liver microsomes also inducer acting receptor wiley periodicals inc
purpose article determine usefulness means method applied decompose reduce term document matrix use gpu computations reduction based truncated decomposition long term process large matrices computational complexity decomposition use means decomposition reduction reduce computational complexity addition use gpu reduce time whole process article comparison times correctness results computing environments associated gpu
article summarizes literature regarding epidemiology prevention unintended pregnancy united states affordable care act accompanying contraceptive provision need primary care clinicians provide family planning services office based interventions incorporate family planning services primary care presented including clinical tools electronic health record use special attention paid long acting reversible contraceptive methods implant intrauterine devices highly effective safe methods greatest potential decrease rate unintended pregnancy
environmental syndrome altered small intestine structure function hypothesized common among individuals lacking access improved water plausible biological mechanisms inflammatory non inflammatory alter cardiometabolic profile test hypothesis associated cardiometabolic profile among young children living environment intense exposure total children participating cohort multicenter study childhood infectious diseases growth development contacted years age urinary ratio plasma antibody core determined order assess intestinal permeability bacterial translocation blood pressure fasting plasma glucose insulin cholesterol apolipoprotein profiles also assessed extant cohort data also used relate biomarkers first months life early child cardiometabolic profile lower intestinal surface area assessed percent excretion associated lower apolipoprotein lower high density lipoprotein concentrations lower intestinal surface area also associated greater blood pressure inflammation months age associated higher blood pressure later childhood study supports potential relationship cardiometabolic profile
paper presents new parallel domain decomposition algorithm based integer linear programming mathematical optimization method minimize computation time coastal ocean circulation models decomposition algorithm global domain local domains balanced work load according number processors avoids computations many land grid cells possible addition maintains use rectangular local domains achieves exact results traditional domain decomposition algorithms decomposition however decomposition algorithm converge exact solution relatively large domains overcome problem developed two decomposition formulations first one complete formulation additional restriction although large global domains second one feasible imposes local domains dimensions looks feasibility decomposition allows much larger global domains parallel performance formulations compared base decomposition simulating two cases newly created parallel version institute coastal ocean model simulations formulations run always faster ones base decomposition complete formulation better feasible one applicable addition parallel efficiency decomposition greater one
bacterial colonization gut shapes local systemic immune response implicated modulation immunity healthy disease states recently quantitative qualitative changes composition gut microbiota detected crohns disease ulcerative colitis reinforcing hypothesis dysbiosis relevant mechanism underlying inflammatory bowel disease ibd pathogenesis humans microbes evolved long time mutually beneficial symbiotic association essential maintaining homeostasis however microbiome dynamic changing age response environmental modifications among environmental factors food habits progressively altered modern societies appear critical modulators microbiota contributing participating dysbiosis addition food constituents important regulators mucosal immunity direct indirect effects gut microbiota moreover food constituents recently shown modulate epigenetic mechanisms result increased risk development progression ibd therefore likely better understanding role different food components intestinal homeostasis resident microbiota essential complex molecular basis epigenetic genetic environment interactions underlying ibd pathogenesis offering dietary interventions minimal side effects
article attempt made solve load frequency control problem interconnected power system network equipped classical pid controller using grey optimization technique initially proposed algorithm used two area interconnected non thermal thermal power system study extended three realistic power systems viz two area multi units hydro thermal two area multi sources power system thermal hydro gas power plants iii three unequal area thermal power system better validation effectiveness proposed algorithm generation rate constraint steam turbine included system modeling dynamic stability systems investigated presence controller gains optimized using algorithm employing integral time absolute error based fitness function performance proposed algorithm compared comprehensive learning particle swarm optimization ensemble mutation crossover strategies parameters differential evolution similar meta heuristic optimization techniques available literature similar test system moreover demonstrate robustness proposed algorithm sensitivity analysis performed varying operating loading conditions system parameters range simulation results show better tuning capability similar population based optimization techniques elsevier rights reserved
paper presents simple state space based method design realization variable band pass band stop digital filters proposed variable filters allow tune frequency characteristics also ensure high performance respect finite effects norm dynamic range scaling limit cycles noise coefficient sensitivity achieve property using preserving frequency transformation implemented replacing delay element given prototype filter second order pass function four multiplier lattice structure shown proposed variable filters described rather simple form without need inverse matrix appeared conventional preserving frequency transformation moreover show high performance proposed method comparison possible types frequency transformations implemented typical one multiplier two multiplier lattice forms direct form elsevier inc rights reserved
paper utilizes modified riemann derivative extended expansion method discuss soliton solutions nonlinear time fractional parabolic equations exact solutions expressed terms hyperbolic trigonometric functions solutions useful desirable explain nonlinear physical phenomena nonlinear fractional calculus several constraint conditions naturally emerge results obtained conditions also listed elsevier gmbh rights reserved
society changing towards new paradigm increasing number old adults live alone parallel incidence conditions affect mobility independence also rising consequence longer life expectancy paper specific problem falls old adults addressed technological solution monitoring users video cameras accelerometers gps sensors combined multi modal approach monitor humans inside outside domestic environment machine learning techniques used detect falls classify activities accelerometer data video gps used provide location inside outside domestic environment results monitoring solution imply confinement users closed environment
paper presents design order feedforward operational amplifier amp applications continuous time delta sigma modulators system level design procedure proposed determine transconductance stage transistor level emphasized achieve power efficiency simulated cmos process amp achieves gain mhz gain ghz power consumption
new solar biomass power generation system integrates two stage proposed paper system two different types solar collectors solar thermal energy different temperature levels applied drive solar biomass processes production solar fuel produced solar fuel namely directly utilized advanced combined cycle system power generation numerical simulations implemented evaluate design design thermodynamic performances system results indicate proposed system achieve overall energy efficiency net solar electric efficiency nominal condition proposed two stage solar biomass routine exhibits improved system thermodynamic performance compared one stage technical mode provided heat resource good match requirements biomass procedure given simulation conditions paper energy level upgrade ratio proposed two stage solar biomass system introduced solar thermal energy high compared one stage mode meanwhile daily average net solar electric efficiency representative days reaches range one stage model research findings provide promising approach efficient utilization abundant solar biomass resources western china reduction emission published elsevier ltd
common debilitating birth defect whose multiple causes poorly understood provide first genetic cholinergic receptor expression link ablation cell lineage condition mouse using homologous recombination cre cassette introduced noncoding region cre identifying cell lineages expressing gene lineage first appears embryonic day neural tube extends cell subsets tissues ablation cre cell lineage embryos expressed attenuated toxin results precise developmental defects including open hypothesized like humans defect modified environmental compounds acid also nicotine prenatal chronic oral nicotine administration substantially worsened defect often include neural tube contrast supplementation maternal diet decreased prevalence dramatically reduced defect severity acid supplementation towards reduced frequency unaffected interventions studies identify cell lineage participating posterior closure present novel model lower substantially modified prenatal environment wiley periodicals inc
context software engineering ubiquitous systems experienced important rapid growth however vast research corpus makes difficult obtain valuable information objective identify evaluate synthesize research relevant approaches addressing different phases software development life cycle ubiquitous systems method conducted systematic literature review papers presenting evaluating approaches different phases software development life cycle ubiquitous systems approaches classified according phase development cycle addressed identifying main concerns limitations results identified papers reporting approaches addressing issues related different phases software development cycle ubiquitous systems approaches aimed addressing implementation evolution maintenance feedback phases others phases testing need attention researchers conclusion recommend follow existing guidelines conducting case studies make studies reproducible closer real life cases phases development cycle extensively explored still room research phases toward agile integrated cycle requirements testing feedback elsevier inc rights reserved
classical objective considers obtained code relation original programs equal functionality present paper reviews another objective considered relatively programs different functionality case provided key input nearly impossible discover programs functionality without key hence type named key paper proves existence key existence effective algorithms operation demonstrated recursive functions practical relevance result obtained research possibility store code computational environment injection attacks distributed computing analysis recursive key application high level applications presented presented application matches recursive functions high level programming language
innate immune system includes toll like receptor signaling plays important role inflammation although common myeloid differentiation factor known multiple effects carcinogenesis role remains unknown study expression examined samples human hepatocellular carcinoma hcc tissue immunohistochemistry western blot quantitative reverse transcriptase polymerase chain reaction methods relationships expression clinical pathological parameters analyzed results showed attenuated expression hcc tissue tumor cells significantly related hepatitis virus infection large tumor size positive vascular invasion metastasis western blot analysis protein nine normal livers showed gender disparity attenuated expression livers low expression mrna evident vascular invasion contrast previous reports results suggest attenuated expression hcc associated tumor progression
hereditary angioedema autosomal dominant inherited disease leading attacks variable severity localization predominantly caused inh deficit mutations already identified however genetic analysis brazilian cohort hae patients inh deficiency published aim perform genetic analysis inh gene brazilian hae patients screened whole coding region subjects unrelated families confirmed diagnosis hae due inh deficiency clinical diagnosis based symptoms quantitative functional analysis inh identified fifteen different mutations among eight previously described according databases found five small deletions producing leading premature stop seven missense mutations one mutation two alterations despite small number participants study results show mutations previously identified gene study represents first brazilian hae cohort evaluated mutations introduces possibility perform genetic analysis case need differential diagnosis
tobacco smoking one risk factors upper tract cancer exclusive quantification impact cigarette smoking laryngeal cancer investigated meta analysis researches reported quantitative estimates cigarette smoking risk laryngeal cancer march performed pooled estimates relative risks confidence intervals obtained summarized sensitivity analysis subgroup analysis implemented find sources research heterogeneity effect potential confounders publication bias investigated corrected found present test fill algorithm thirty researches based total cases three cohort fifteen case control studies included pooled estimate correlation cigarette smoking risk laryngeal cancer confidence interval moderate heterogeneity across researches cohort studies case control studies risk kept elevated within first fifteen years quitting smoking dropped years smoking cessation individuals smoked pack years nine times risk laryngeal cancer subjects smoked cigarettes day risk laryngeal cancer smoked years five times risk versus never smokers evidence publication bias detected correlation current cigarette smoking risk laryngeal cancer test test results demonstrated strong correlation referring dose response time response cigarette smoking risk laryngeal cancer men women probability developing laryngeal cancer decreased quitting smoking particularly among former cigarette smokers stopped smoking years subgroup analysis demonstrated study type influenced estimates studies
objective increase level awareness syndrome eds vitamin deficiency associated fragility fractures features reported caused non accidental trauma due child abuse neglect patients methods constructed case series largest date infants eds vitamin sufficient insufficient deficient infants without eds documented vitamin deficiency evidence presented multiple fractures originally diagnosed non accidental caused child abuse infants referred outpatient bone health care clinic university medical campus year period also present index cases court concluded convincing evidence child abuse infants returned parents institutional review board approval obtained results present cases infants multiple fractures diagnosed caused non accidental trauma infants younger one year age among clinical evidence eds family history confirmed clinical diagnosis least one parent eds without evidence eds vitamin deficiency three eds infants diagnosed eds overlap syndrome common fractures noted diagnosis extremity fractures including classic lesions serum levels reported infants mothers sixty three percent eds infants serum measured vitamin deficient mean serum level infants vitamin deficiency conclusion eds eds vitamin deficiency associated fragility fractures infants caused non accidental trauma due child abuse
energy storage systems utilize reversible reactions store solar energy chemical form present work focuses cobalt oxide pair based redox cycle active oxide coated structure redox cycle cobalt oxide releases oxygen air stream coming direct contact thus air acts reaction medium heat transfer fluid configuration storage material works heat storage medium also heat exchanger two dimensional numerical model simulate heat mass transfer chemical reaction heat storage reactor developed experimental results capacity prototype reactor installed solar tower test facility germany used validate numerical model time dependent boundary conditions form inlet temperature inlet mass flow rate experiments employed numerical model temperatures redox material different locations inside prototype storage heat exchanger reactor used numerical model validation total energy stored released chemical experiments also compared numerical model results study concluded numerical model accurately predict charging processes cobalt oxide based storage reactor system multiple redox cycles model allows better understanding complete process helps identify effect variation boundary conditions system elsevier ltd rights reserved
little known risk factors suicide ideation attempts among domestic violence offenders guided interpersonal psychological theory suicide cross sectional study examined risk factors suicide ideation attempts among men women domestic violence mandated attend intervention programs men reported greater capability suicide gender differences found perceived controlling correlates suicide ideation perceived interaction perceived associated suicide ideation suicide exhibited greater perceived drug use problems borderline personality disorder symptoms depressive symptoms suicide ideation capability suicide gender moderate associations constructs suicide ideation attempts findings parallel tests interpersonal psychological theory samples additional work needed identify factors distinguish risk suicide ideation risk suicide attempts among domestic violence offenders
simulation model current rotary drilling rig system built according basic configuration type rotary drilling rig test rig based working principle system built results show simulation model system accurate reasonable means comparative analysis theoretical computation test data working principle logic threshold control method system presented reduce fuel consumption improve energy saving efficiency via analysis energy flow system mainly includes engine electric motor generator super capacitor rectifier inverter torque etc finally comparative analysis fuel economy hybrid drilling rig system completed overall typical operating conditions results show energy saving efficiency system total fuel economy efficiency reaches relatively typical operating condition published elsevier ltd rights reserved
proliferation endometrial cells prerequisite step functional differentiation uterus tumor suppressor gene cyclin dependent kinase associated protein mrna detected pregnant uterus suggested involved cell proliferation however roles mechanisms regulating expression largely unknown study role steroid hormones expression examined using pcr northern blotting situ hybridization methods mrna highly expressed phase mainly localized epithelium expression induced single injection estradiol progesterone effect progesterone stronger estradiol injections progesterone consecutive days induced expression patterns served phase injections estradiol consecutive days induce expression mrna level decreased combined treatment progesterone estradiol suppressed completely mrna expression day gestation expression also regulated progesterone expected mrna expression totally suppressed thus suggested expression primarily regulated progesterone progesterone receptor uterus mainly localized proliferating tissues
provide integrative review basic control circuits introduce techniques regulation quantitatively measured using human neuroimaging illustrate utility control systems approach using four human neuroimaging threat detection studies applied circuit wide analyses order identify key mechanism underlying individual variation build upon canonical prefrontal limbic control system integrate circuit wide influence inferior frontal gyrus incorporated computational control systems model constrained designed replicate experimental data model acts informational set point gating signals primary prefrontal limbic negative feedback loop cortical information gathering loop along cortical route sensory cortex provides sufficient information make threat assessment signal passes prefrontal cortex whose threat detection threshold subsequently modulates amygdala outputs however signal outputs sensory cortex provide sufficient information first pass signal loops back sensory cortex cycle providing increasingly fine grained processing sensory data simulations replicate chaotic dynamics experimentally observed ends threat detection spectrum identify distinct types circuit associated clinical outcomes thresholds high sensory cortex cycle long coarse grained excitatory pathway dominate ambiguous stimuli false positives hand cortical thresholds low inhibitory pathway suppress amygdala without cycling back sensory cortex much needed fine grained sensory cortical data ambiguous stimuli false thus control systems model provides consistent mechanism regulation capable producing results consistent data full spectrum threat detection optimal generally illustrates quantitative characterization circuit dynamics used fundamental dimension across psychiatric affective symptoms
background china large population children years age whose health great concern chinese health care system however studies conducted analyze factors associated childrens unnecessary health care utilization china objective study provide empirical evidence issue investigating role parental health care utilization childrens unnecessary health care use methods data obtained fifth health service survey province employed three dependent variables measure childrens health care utilization number childrens outpatient visits past weeks whether infusion used child outpatient visits past weeks number childrens inpatient visits last year based specific characteristics outcome variables negative binomial models used non negative numbers outpatient inpatient visits model used zero one indicator variable showing whether infusion used outpatient visits results based sample children results multivariate analysis showed children whose parents used outpatient care estimated larger number outpatient visits whose parents outpatient visits past weeks difference visits among children outpatient visits last weeks probability obtaining infusion percentage points higher children whose parents used infusion past weeks probability whose parents use infusion predicted number inpatient visits higher children whose parents used inpatient services last year compared group whose parents use difference visits moreover noted positive association parental childrens health care use prominent among younger children conclusions chinese children whose parents high health care users likely overuse health care services holding factors constant parents play important role reducing childrens unnecessary outpatient visits infusion use inpatient visits results suggest interventions aimed affecting patterns parental use helpful improving appropriate health care utilization children
known important class drugs treatment autoimmune inflammatory diseases patent biotechnological manufacturers now develop drugs due introducing new complex portuguese association hospital pharmacists gathered develop common positioning use monoclonal antibodies main european pathway approval developed improve access biological therapies remains work progress unresolved issues remain due present reality monoclonal antibodies hospital pharmacists play important role ensuring safe effective cost effective use health systems educating healthcare administrators providers policymakers patients products new conclusionthe conclusions presented work focused proposal optimal prescription criteria preparation original biologics pharmacy management selection extrapolation issues specific role risk management optimal use monoclonal antibodies
conclusions purpose set describe modern day management lymphocytic respect diagnosis treatment long term endocrine visual outcomes included patients clinical diagnosis compared histological diagnosis following surgery methods multi centre observational study performed twenty two patients included studied mean follow period years range years results patients presented headache visual field disturbances combination symptoms time lag onset symptoms diagnosis months approximately third patients respectively two thirds patients diagnosed based clinical biochemical radiological findings surgical cohort statistically likely presented larger lesions extension greater visual field defects follow improvement headaches visual symptoms rate reflected need going pituitary hormone replacement persisted year follow significant difference medically surgically managed cohorts terms ongoing symptomatology need pituitary hormone replacement modern era patients diagnosed non surgical means managed medically remains significant time lag onset symptoms eventual diagnosis despite considerable morbidity attached overall prognosis good
retinal deposition histologic indicator sustained hemorrhage used precisely estimate time since episode trauma month old male infant admitted hospital acute deterioration examination revealed retinal consistent abusive head trauma age hospital spontaneous fracture right femur patient deteriorated died unsuccessful investigation showed atrophy retina optic nerve deposition eyes retinal deposition currently generally assumed within weeks occurrence hemorrhage case report describes infant bilateral retinal due sustained occurring months prior death implications finding interpretation retinal discussed
performance four sections full scale constructed soft soil examined using fully coupled fully three dimensional finite element analysis four sections similar loadings different improvement options one one support one single layer geotextile reinforced platform support one two layers geogrid reinforced platform support like field data numerical results show inclusion decreases settlement surface section addition single layer geotextile reinforcement reduced settlement section effects geosynthetic reinforcement multiple layers reinforcement performance supported discussed relative load transfer calculated using eight existing methods compared field measurements numerical results
purpose purpose research investigate organizations best facilitate workforce makes autonomous decisions acts literature high performing organizations increase likelihood sustained performance retaining competitive advantages introduce novel mechanism encouraging behaviors outcomes learning demonstrates autonomy design methodology approach experimental data sample participants underwent managerial simulation used data investigate relationships learning behaviors individual task performance findings results indicate behave autonomy increases extent individuals behave similarly associated enhanced individual performance find behavior fully mediates relationship behavior performance implications findings show need necessarily engage directly empowering others rather modeling behaviors context employees act autonomy efficiency provides opportunity empowerment cost effective originality value first study consider empowerment managerial phenomenon learned integrating theories social learning empowerment extending existing empowerment constructs including psychological structural develop indirect yet potent means encouraging behavior
background contaminants important source allergens young people present case severe patient also suffered symptoms urticaria whenever ingested methods prick tests battery including fruits fruits orange specific ige allergens carried performed using patients serum following allergens candida aspergillus recombinant laboratories results skin tests negative candida aspergillus spain specific ige antibodies cap sweden positive candida specific ige tests pollen fungi foods positive serological study fungi ruled fungal infection time showed patients serum recognised protein approximately kda one approximately kda perfectly recognised conclusions surface contaminated candida fungi positive skin tests possibility serious complications taken account published elsevier espana slu rights reserved
randomization uses genetic data probe questions causality epidemiological research instrumental variable assumptions recent years become attempt analyses summary data estimates genetic association large independent study populations referred two sample summary data unfortunately due number variants easily included summary data analyses increasingly likely meet assumptions due pressing need develop methods detect correct order preserve validity approach context paper aim clarify established methods meta regression random effects modelling mainstream meta analysis adapted perform task specifically focus two contrasting approaches inverse variance weighted method assumes simplest form genetic variants valid method regression allows variants assumptions albeit specific way investigate ability two popular random effects models provide robustness approach propose statistics quantify relative fit approach regression authors statistics medicine published john wiley sons ltd
current study examined associations mothers behavioral profiles mother child conflict interactions childrens social skills person centered approach classified mothers according levels emotional responsiveness negativity engagement facilitation behaviors eight minute conflict discussion task child three distinct classes mothers identified using latent profile analysis sensitive engaged moderately sensitive engaged insensitive analysis covariance indicated children mothers sensitive engaged group significantly higher social skills children mothers moderately sensitive engaged insensitive groups results suggest mother child conflict interactions benefit childrens social development mothers facilitate childrens participation highly sensitive manner
supervised classification methods widely used hyperspectral remote sensing image analysis however require large number training samples guarantee good performance costs large amount time human labor motivating researchers reuse labeled samples mass pre existing related images transfer learning methods adapt knowledge existing images solve classification problem new yet related images drawn increasing interest remote sensing field however existing methods field require images share dimensionality prevents practical application paper focuses transfer learning problem heterogeneous spaces dimensions different propose novel iterative heterogeneous transfer learning framework iteratively common space source target data novel iterative strategy source samples iteration heterogeneous data first mapped common space two projection functions based weighted support vector machine second based common subspace source data using iterative strategy transferring according relative importance experiments undertaken three data sets confirmed effectiveness reliability proposed method
background many micrornas mirnas recently shown demonstrate critical roles differentiation proliferation migration vascular smooth muscle cells methods results study certain amount mirna expression evaluated real time polymerase chain reaction found microrna mir expressed strongly common vascular expressed mirnas vitro subsequently gain loss function study performed vitro vivo found mir strongly downregulated concomitantly stimulation mir inhibited proliferation migration vitro vivo furthermore ubiquitin enzyme identified target gene endogenous mir luciferase reporter assay confirmed overexpression mir significantly reduced inhibited phenotypic switch knockdown influence proliferation migration cultured mir mimic overexpression mir induced apoptosis deregulated protein expression crucial signal pathway conclusions results study indicated mir exerted anti atherosclerosis effect via inhibiting proliferation migration promoting apoptosis specifically demonstrated mir exhibited effects partially targeting kappa kappa signaling pathway
despite recent increase existing buildings literature continues focus investigating barriers new buildings goal research develop method using failure mode effects analysis investigate barriers existing buildings using leadership energy environmental design version building operations maintenance existing buildings rating system specific objectives included using method investigate potential failure modes existing buildings using rating system causes effects rank failure modes effects causes order priority identify opportunities lessons learned implementing method research involved bringing together focus group five local experts familiar rating system one day workshop experts along research team identifying potential failure modes along causes effects detection controls rating probability occurrence failure modes severity failure effects ease detection failure controls analysis workshop data showed half identified failure causes technical nature financial causes organizational causes representing failure causes respectively analysis also showed intricate relationship technical financial organizational social environmental factors therefore different factors need integrated rather separated research provided new comprehensive method based use failure mode effects analysis evaluate risks existing buildings using leadership energy environmental design rating system workshop participants found failure mode effects analysis excellent method identifying evaluating ranking green building certification risks helped foster interdisciplinary collaboration participants various disciplines researchers industry stakeholders nevertheless need future applications method limit scope analysis specific categories credits rating system narrow scope facilitate analysis workshop data enable depth comprehensive analysis risks risk types including ones traditionally tend ignored organizational social risks elsevier ltd rights reserved
mixed results reported metal surfaces graphene serves effective short term barrier corrosion oxidation due low permeability gases cell graphene metal substrate facilitates extensive corrosion long run defects graphene layer provide pathways species study role defects graphene using first principles theoretical modeling experiments highly reactive environment indicate oxidized products primarily distribute along grain boundaries graphene analyze thermodynamics absorption grain boundaries graphene basis density functional theory insertion sites favorable interstitial facilitate structural transformation graphene significantly decrease mechanical strength graphene layer furthermore presence interstitial chemical stability graphene enhancing promoting dispersive growth along grain boundaries
recent years transportation emerged trend support energy efficiency emissions reduction targets true success however trend depends successful integration electric transportation modes infrastructure systems support left plug electric vehicles suffer delays due charging cause charging loads electrical grid online electric vehicles emerged need stationary charging effects many works sought mitigate effects advanced control functionality coordinated charging vehicle grid stabilization charging management works assessed impacts holistic transportation electricity paper develops hybrid dynamic system model transportation also includes next generation traffic simulation concepts model used transportation operators just assess also improve operations control hybrid dynamic system model composed marked net model continuous time kinematic electrical state evolution model demonstrated illustrative example moderate size functional heterogeneity
series experiments conducted study bed load transport motion bed load particles captured series images taken high speed motion tracking method developed automatically detect moving particles calculate instantaneous particle velocities instantaneous bed load transport rate calculated based particle velocity volume moving particles verify method bed load transport rate based image processing technique compared manually measured ones data experiments results showed new technique made possible quantify spatial temporal variations bed load transport rate individual particle scale international research training centre erosion sedimentation world association sedimentation erosion research published elsevier rights reserved
background low testosterone levels men treated radical prostate cancer associated worse pathological stage outcomes long term data correlating preoperative testosterone levels outcomes presented methods total patients identified preoperative testosterone levels treated long term follow associations testosterone levels tumor stage score time biochemical failure assessed using pearsons chi square test test spearman rank correlation life table methods kaplan meier curves log rank test cox proportional hazards model appropriate testosterone analyzed continuous factor low versus normal testosterone levels results median testosterone level median age years median follow approximately years significant association testosterone values positive surgical margin vesicle invasion found patients testosterone level also showed higher percentage time years difference statistically significant log rank test adjusted known predictors score pre prostate specific antigen vesicle involvement positive surgical margin effect testosterone continuous predictor statistically significant conclusion longest follow date years correlating preoperative testosterone levels outcomes presented study low testosterone levels significantly associated positive surgical margin vesicle invasion slightly higher rates
asymptomatic nature infections lack appropriate effects current prevention management call vaccine development evaluated recombinant subunit vaccine candidate based major outer membrane protein variable segments achieve maximal immunogenicity ease production purification constructed using highly immunogenic sequences thereby minimizing presence hydrophobic regions spacing immunogenic epitopes flexible amino acid sequence purification tag also added given without boost toxin adjuvant mice screened immunogenicity protection live challenge infection bacterial shedding cell mediated responses antibody responses monitored mice exhibited significantly less bacterial shedding better protected infertility compared control mice stimulated systemic local specific antibody iga responses primed cells produced interferon upon challenge recall antigen thus combination adjuvant stimulated effector cells generated protective immunity associated less pathology regard promising candidate development mucosal vaccine
background false positive test results children tested food allergies lead inappropriate dietary restrictions objective aim study report experience year old boy presented multiple food allergies however passed food challenges review experience regarding management children high specific food high total ige methods medical records children food challenges reviewed median age subjects months history adverse clinical reaction food specific ige greater decision point elevated total serum ige level underwent challenges offending food results subjects successfully exposed suspected foods continued tolerate foods conclusion finding suggests much lower clinical risk previously defined specific ige decision points children high levels total ige
increased infections hospitals multidrug resistant resistant isolated humans animals food sources raised public health concern presence multiple sources performed comparative analysis antimicrobial resistance genetics isolates derived fresh produce human fecal samples isolates fecal produce isolates resistant gene isolates showed multidrug resistant properties isolates fresh produce study showed common shared characteristics isolates humans results antimicrobial resistance sequence typing analysis therefore isolates fresh produce likely related derived humans results suggested vegetables environment contaminated vegetables act vehicle human infections ongoing nationwide surveillance antibiotic resistance promotion proper use antibiotics necessary
background psoriatic arthritis psa inflammatory musculoskeletal disease develops approximately patients psoriasis previously chemokine motif ligand identified predictive biomarker psa patients psoriasis reduced development psa purpose present study explore messenger rna mrna protein expression receptor chemokine motif receptor joints patients psa gain insight role pathogenesis disease methods sera patients psa healthy control subjects compared expression assay synovial fluid obtained patients psa osteoarthritis rheumatoid arthritis clinical care mrna protein expression interleukin interferon ifn gamma compared among mentioned disease groups paired serum samples patients psa using real time polymerase chain reaction assays respectively results serum significantly higher patients psa control subjects expression elevated cells patients psa compared patients patients elevated psa cells compared patient groups concordant results obtained protein expression ifn gamma elevated psa compared protein expression substantially increased median interquartile range iqr compared paired serum samples median iqr whereas ifn gamma significantly reduced median iqr versus serum median iqr conclusions important etiological role psa analogous candidate biomarker distinguish psa healthy individuals patients
objectives hypothesis although geometry vocal fold medial surface affects voice quality critical treatment insufficiency shape vocal fold medial surface understood study activated intrinsic laryngeal muscles individually combinations recorded temporal sequence precise three dimensional changes vocal fold medial surface study design vivo canine model methods performed vivo canine model used mark medial surface situ vocal fold grid like fashion lateral lca posterior pca muscles stimulated individually combinations right angle whose formed provided two distinct views medial surface high speed digital camera image processing package inc germany allowed time series cross correlation analysis three dimensional deformation calculations vocal fold medial surface results combined lca activation yields rectangular surface addition vocal fold inferior superior graded fashion allowing formation divergent posterior relationship favoring lateral yield unique necessary likely conducive efficient conclusions understanding three dimensional geometry vocal fold medial surface help better understand cause effect relationship laryngeal physiology
context mechanisms mediating short long term improvements glucose homeostasis following bariatric metabolic surgery remain incompletely understood objective investigate whether reduction adipose tissue inflammation plays role metabolic improvements seen bariatric metabolic surgery short term longer term design fasting blood subcutaneous abdominal adipose tissue obtained one month months bariatric metabolic surgery individuals obesity insulin anti diabetes medication adipose tissue inflammation assessed combination whole tissue gene expression flow cytometry based quantification tissue leukocytes results one month surgery body weight reduced improvements glucose tolerance reflected decrease area curve auc glucose oral glucose tolerance tests mmol min enhanced pancreatic beta cell function index mmol change estimated insulin sensitivity insulin sensitivity index furthermore although biomarkers systemic inflammation pro inflammatory gene expression adipose tissue remained unchanged number neutrophils increased adipose tissue fold less substantial increases leukocyte populations month follow visit body weight reduced relative baseline glucose tolerance improved auc glucose along estimated insulin sensitivity addition improvements systemic inflammation reflected reductions circulating reactive protein crp increased serum adiponectin however leukocyte infiltration adipose tissue remained elevated relative baseline pro inflammatory cytokine mrna expression unchanged adiponectin mrna expression downward conclusion short longer term metabolic improvements following bariatric metabolic surgery occur without significant reductions measures adipose tissue inflammation assessed measuring expression genes encoding key mediators inflammation flow cytometric quantification adipose tissue leukocytes elsevier inc rights reserved
background objectives mothers living hiv encouraged transmit hiv infants however little known women hiv perceive experience infant feeding practices paper explores breastfeeding experiences among women living hiv southern thailand methods semi structured interviews drawing methods used hiv positive women rural communities southern thailand thematic analysis used data analysis findings hiv positive mothers ambivalent feelings able infants perceived contaminated mother healthcare centres hospitals supply free infant formula hiv positive mothers one half years despite many mothers deal difficulties infants developed allergy infant formula free infant formula sufficient infants mothers find alternative means infants many mothers relied milk whereas fed women made every effort fulfill ideology good responsible mother conclusion paper contributes conceptual understanding lived experiences breastfeeding among women living hiv southern thailand findings implications care health policy provision different options feeding made available infants along accessible resources professional support guidance
idiopathic pulmonary fibrosis ipf fatal progressive lung disease occurring adults last decade results number clinical trials based updated disease classification published registration first two pharmacological treatment options approved ipf marks new chapter management patients disease treatments lung transplantation rehabilitation also shown beneficial patients review past present management discussed based comprehensive literature search treatment algorithm presented based available evidence overall clinical experience addition unmet needs regard treatment highlighted discussed describe development various treatment options ipf first consensus recent guidelines based evidence large scale randomized clinical trials led registration first drugs ipf
background although past decade management invasive fungal infections improved number controversies persist regarding empirical antifungal treatment critically patients aims identify key clinical knowledge elaborate set recommendations high level consensus necessary approach fungal infections critically patients methods spanish prospective questionnaire measures consensus delphi technique answered multidisciplinary national experts specialists fungal invasive infections six scientific national societies specialists infectious diseases responded questions prepared coordination group thorough review literature published last years category selected level agreement among experts category equal greater second round specialists attended face face meeting held extracting recommendations chosen topics validated pre selected recommendations derived algorithm results assess administering antifungal treatment patients high medium risk factors fever days onset antibiotic therapy event negative detection analysis performed relevant findings sinus chest computed tomography detected case patient receive prophylaxis administered treatment recommended event patient received prophylaxis activity fungi administration amphotericin recommended second choice therapy event prophylaxis received amphotericin therapy recommended second choice assess administering antifungal treatment patients high medium risk factors fever days onset antibiotic therapy event positive sinus chest suggests fungal infection caused fungi event patient receive antifungal prophylaxis administered recommended treatment choice amphotericin patient received prophylaxis activity fungi administration amphotericin recommended monotherapy amphotericin combination recommended second choice therapies event administered prophylaxis amphotericin recommended treatments choice consider administration antifungal treatment patients high medium risk factors fever days onset antibiotic therapy event negative sinus chest suggests fungal infection caused fungi patient receive prophylaxis administered recommended treatment choice amphotericin case patient received prophylaxis activity fungi administration amphotericin recommended first choice therapy amphotericin combined second choice event administered prophylaxis amphotericin recommended treatments choice conclusions empirical antifungal approach critically patients requires application broad range knowledge skills described recommendations algorithm recommendations based delphi methodology help identify potential patients management improve overall prognosis published elsevier espana slu rights reserved
objectives youth participation competitive significantly increased past two decades also recent rise number sports injuries physicians seeing young athletes objective study assess likelihood sports injuries based several risk factors general sample athletes area high cross sectional study online survey distributed student athletes local high school mean age years four hundred eighty four complete responses received data collected survey included demographics frequency sports participation level participation types sports played participation cross training injuries incurred use non steroidal anti inflammatory drugs treatment sports athletes played average different sports average number hours participation sports annually hours average total number sports injuries experienced athletes study per participant respondents reported sustained least one sports higher total number hours per year sports participation playing contact sport significantly associated reported lifetime sports injuries older age playing contact sport playing travel team associated students using nsaids sports injuries older age playing contact sport cross training also associated surgery sports although hours participation playing contact sport lead increased number injuries risk myriad benefits sports provide young athletes
syndrome crisis unilateral ocular condition characterized recurrent attacks anterior raised pressure result chronic secondary relatively rare disease likely result recurrent cytomegalovirus infection affects predominantly middle aged males diagnosis largely clinical aqueous blood sampling identification underlying infectious cause successful disease management often achieved topical treatment although systemic therapy even surgical intervention required discuss current understanding syndrome pathophysiology recommended treatment options elsevier inc rights reserved
one third adult patients surgery mandible show relapse sagittal split mandible leads displacement parts without changes muscle attachment changed mandible length needs adaptation muscle capacity changed force moment ratio aim microarray study analyze general genetic response muscle patients mandible six months surgery comparison healthy untreated controls found tissue samples muscle reduction different entities patients controls less patients different entities controls reduced increased consider total amount different entities controls higher patients mandible strong genetic controlled development compared patients mandible environmentally influenced concluded function follows form surgical change high inheritance patients adaptation delayed capacity regeneration potential sufficient european association facial surgery published elsevier ltd rights reserved
consumer protection electricity pricing issues emerge consumers generate electric power installing solar photovoltaic panels known solar distributed generation nowadays centre interest public administration citizens far concerns energy supplies households new inter relations occur result technological advance despite fact output solar panel precisely predicted marginal cost generating electricity renewable energy sources nearly zero made renewable sources inclusion solar panels first choice utility firm fulfilling customers energy demand look economics electricity pricing issue consumer protection associated distributed generation developed example usa results help stakeholders policy makers energy companies obtain deeper insight given united states affected climate change use solar renewable energy great benefit controlling environmental hazards caused use non renewable energy environment government socially influential stakeholders initiate participate public awareness campaign concerning policies concept net pricing solar products
water consumption residential parts urban areas just one part water management problems contemporary potable water management sustainable whereas use potable water flushing irrigation washing vehicles appropriate solution substitute potable water rainwater purposes water source considered sustainable submitted paper presents risk assessment using risk analysis rainwater harvesting rwh system paper deal system details selected approach evaluation methodology verified analytical hierarchy process authors published elsevier ltd
background laparoscopic adjustable gastric safe proven surgical option morbid obesity however need surgery increasingly reported study reports outcomes incidence large cohort patients requiring surgery various indications methods retrospective review prospectively collected data primary placed single surgeon single institution performed analysing data patients cohort requiring surgery results total performed patients total patients single revision patients two band band removal band removal conversion another bariatric procedure mostly gastric bypass total band band revision patients lost follow patients undergoing band band revision band patient intolerance mechanical band failure mean excess weight loss years respectively port included mean follow band band revision patients months standard deviation months patients required one band revision procedures increased conclusion continued achieved replacement however significant increasing rate operation time exists
endoscopy remains main technique diagnosis treatment crohns disease nevertheless recent development innovative non invasive imaging techniques led new tool exploration small bowel patients paper reviews available data ultrasound imaging used evaluation highlighting role small intestine contrast enhanced ultrasonography use oral intravenous contrast agents
large dose ranging study explored benefits different combinations health related quality life hrqol based patient reported outcomes pros patients responders achieving clinically meaningful improvements efficacy hrqol phase placebo monotherapy controlled dose ranging week trial adult patients overactive bladder oab months randomized groups combination monotherapy placebo change baseline end treatment assessed versus placebo pros oab symptom total hrqol patient perception bladder condition score responders achieving minimally important differences pros predetermined clinically meaningful improvements efficacy changes pros responders analysed using model logistic regression respectively full analysis set included patients combination therapy significantly improved pros versus placebo significantly responders achieved pros efficacy frequency normalization approximately twofold greater versus combining improves objective subjective efficacy outcomes compared placebo
obesity diabetes metabolic diseases increasing prevalence dynamics gene expression associated diseases fundamental identifying genes involved related biological processes qpcr sensitive technique mrna quantification commonly used method gene expression studies however reliability results directly influenced data normalization reference genes major normalization method used work aims identify reference genes qpcr adipose tissues mice type diabetes obesity selected genes commonly used reference genes expression genes adipose tissues mice analyzed context three different experimental protocols untreated animals high fat diet animals streptozotocin treated animals gene expression stability analyzed using four different algorithms data indicate binding protein stably expressed across adipose tissues control animals gene also useful reference brown adipose tissues control obese mice analyzed mitochondrial atp synthase complex gene exhibits stable expression subcutaneous adipose tissue control obese mice moreover gene best reference qpcr normalization adipose tissue streptozotocin treated animals results show perfect stable gene suited use experimental conditions conclusion selection appropriate genes prerequisite ensure qpcr reliability performed separately different experimental protocols elsevier masson sas rights reserved
signal flow graph nonlinear modeling method employed develop unified model parallel converter coupled derivation large small signal steady state models unified signal flow graph demonstrated converter performance expressions steady state small signal characteristic transfer functions derived large signal model developed programmed simulator large signal load supply disturbances obtained furthermore validate signal flow graph modelling large signal responses compared simulator results closely matching thus validating signal flow graph modelling
paper describes whole procedures determine ice induced global loads ship using measured full scale data accordance method proposed canadian hydraulics centre national research council canada ship motions degrees freedom dof found processing commercial sensor signals named motion assumption rigid body motion linear accelerations angular rates measured motion data eliminate noise measured data signals due resolution sensor band pass filter passes frequencies cubic spline interpolation applied dof motions computed integrating differentiating filtered signals added mass damping force ship computed dimensional panel method assumption zero frequency coefficients hydrodynamic data dof motion data obtained global ice loads computed solving fully coupled dof equations motion full scale data acquired old ice high estimated ice impact forces two representative events showed ship operated heavy ice conditions copyright production hosting elsevier behalf society architects korea
myeloproliferative neoplasms mpns rare diseases include classic entities vera essential primary myelofibrosis short report minor allele frequencies common mpn mutations compared blood donor population populations european descent using data haplotype map project array platform utilised identifying nine single nucleotide polymorphisms snps six proxy snps variability allele frequencies mpn mutations account different incidence rates seen populations european giving better understanding genetic predisposition mpns copyright john wiley sons ltd
investigate reliability new house automatic algorithm calculating magnetic resonance index large multicentre study population patients affected progressive palsy parkinsons disease healthy controls compare diagnostic accuracy automatic manual values study included patients patients controls mri performed using automatic manual values evaluated accuracy methods distinguishing controls calculated statistical differences found automated manual values groups automatic values differentiated accuracy manual accuracy manual accuracy respectively study showed new house automated method calculation highly accurate distinguishing automatic approach allows widespread use clinical practice longitudinal research studies cent new automatic method calculating presented cent automatic values good agreement manual values cent automatic distinguish patients patients cent automatic method overcomes application limitations routine practice cent automatic method allow widespread use
schedules major concerns construction planning management mutual among construction activities long distance complicated intensive layout affect scheduling degree especially conclusive influence underground construction determination methods current construction simulation trend extrapolation observations fully consider inherent characteristics transition probability different classifications present study authors propose hierarchical simulation model coupling critical path method cycle operation network intricate construction sequence additionally markov prediction model embedded model specific component consider uncertainty estimate construction parameters cycle automatically based proposed simulation model real time construction schedule analysis system built case study project analyzed demonstrate feasibility methodology highlight capabilities project reasonable planned schedule proposed optimal equipment selection determined intensity balanced verified simulation model considering uncertainty using markov process provides higher level accuracy prediction traditional simulations finally regulatory measures presented site management based simulation results deviations actual planned schedules american society civil engineers
information distribution forest types land cover classes essential decision making significant climate regulation biodiversity conservation societal issues approach combination advanced advanced land observing satellite array band synthetic aperture radar full data purpose forest type classification proposed using support vector machine svm classifier classified forest types selected indian region tested classification performance method forest types classified results assessed confusion matrix based statistics results suggest incorporation various features gray level occurrence matrix svm classification overall accuracy supervised classification algorithm kappa observed integration information give information forest type discrimination produce high accuracy maps approach overcomes limitations optical remote sensing data continuous cloud coverage areas society photo optical instrumentation engineers spie
objective suitable magnetic resonance imaging mri techniques conventional new devices help physicians diagnosis follow multiple sclerosis patients aim present research compare effectiveness fluid attenuation inversion recovery sequence conventional mri diffuse weighted imaging sequence new technique detection brain plaques materials methods analytic cross sectional study sample size assessed people detect significant difference two sequences level sequences without contrast brain mri consecutive patients referred mri center hospital iran january evaluated results thirty two females males mean age range evaluated finally plaques including detected sequence efficient detection brain plaques round amorphous plaque shapes frontal occipital lobes corpus subcortical basal ganglia plaques diameter detected plaques sequence smaller conclusion old lesion detected conventional mri new techniques useful early inflammatory phase assessment experimental treatments
aim intrinsic parameterization computational optical system applied long distance displacement measurement large scale structures structural monitoring scenario observation distance established digital camera reference targets composed computational optical system range requiring use long focal length order obtain suitable sensitivity three dimensional displacement measurement observed structure reduced magnitude intrinsic parameterization long focal length cameras emergent issue since conventional approaches applied reduced focal length cameras suitable mainly due conditioned matrices least squares estimation procedures describe intrinsic parameterization long focal length camera optical element method present obtained estimates measurement uncertainties discussing contribution systems validation calibration field test displacement measurement campaigns long span suspension bridge society photo optical instrumentation engineers spie
objective although increasing evidence shown long noncoding rnas play important regulatory role differentiation mesenchymal stem cells little known role sinus membrane stem cells goal study investigate expression profile function osteogenic differentiation methods using microarray identify novel differentiation related functional role regulating evaluated quantitative real time polymerase chain reaction western blot red staining bioinformatic analyses predicted target genes gene ontology pathway network analysis applied study show gradually upregulated osteogenic differentiation overexpression upregulated whereas silencing decreased expression osteogenic key marker related transcription factor depth analyses showed acts molecular microrna mir prevents mediated act competing endogenous rna microrna mir leading heightened expression thus promotes
recent years researchers field structural health monitoring rigorously replace conventional evaluation techniques smart material based structural health monitoring techniques techniques possess distinct advantages conventional techniques capable providing autonomous real time reliable cost efficient monitoring instance electromechanical impedance technique employing smart impedance transducer lead known sensitivity detecting damage signatures electromechanical impedance technique structural health monitoring susceptible variation static load applied host structure ignored article presents series experimental analytical numerical studies conducted investigate effect varying axial load presence fixed boundary condition signatures theoretically vibration affected static axial load acting direction however useful identifying effect caused boundary condition upon increase axial force contributes discrepancy experiments analytical models study suggests effect boundary condition substantial carefully considered real life application electromechanical impedance technique structural health monitoring
paper considers relational databases containing uncertain attribute values knowledge available less certain value values given attribute propose possibility theory based model suited context extend operators relational algebra handle relations compact thus efficient way shown model representation system whole relational algebra important result data complexity associated extended operators context classical database case makes approach highly scalable
rotating electrical machine design magnetic equivalent circuit based reluctance network method seems fair tradeoff computational time precision therefore paper deals semi analytical calculation method direct axis magnetic circuit reluctance synchronous machines means nonlinear reluctance network corresponding non linear equation systems derived forming separated equivalent magnetic networks stator multiple flux barrier rotor divided air gap adaptive interconnection network model air gap needed result simplifies analysis compared conventional reluctance network calculation one global system however analytical calculation model provides results significantly faster finite element method fem sufficient precision thus suitable first rough design
functional neuroimaging studies revealed importance role cognitive psychological factors dysregulation brain gut axis functional gastrointestinal disorder patients although small number neuroimaging studies conducted functional gastrointestinal disorder patients despite fact neuroimaging technique requires high level knowledge technique still great deal potential application functional magnetic resonance imaging fmri technique functional gastrointestinal disorders provide novel methods diagnosing treating patients review basic knowledge technical practical issues fmri introduced clinicians
dopamine plays crucial essential role function human metabolism important develop selective sensitive materials detection dopamine without interference coexisting compounds study conjugated graphene oxide developed system used novel supporting matrix adsorption based selective sensitive detection dopamine conjugated graphene oxide showed high affinity selectivity times higher coexisting molecules ascorbic acid uric acid respectively compared affinity non specific negligible low detection limit obtained experiments carried neutral solutions around physiological study provides simple easy method selective sensitive detection dopamine mixture abundant coexisting molecules generally cause interference elsevier rights reserved
paper approach optimization magnetic design permanent magnet linear generator exploitation energy contained sea waves presented approach consists two step procedure first one takes account stochastic features sea wave motion describe working condition machine motion adopting lumped parameter model step objective function energy production second step optimizes generator using results obtained first step constraints fulfilled design based finite element method fem analysis furthermore approach applied design build linear generator experimental tests carried built linear generator presented
etiology underlying mechanisms pregnancy associated osteoporosis still unknown since systematic analyses exist results indicate heterogeneous rare severe disease including substantial number fractures significant delay first symptom diagnose pregnancy associated osteoporosis rare severe type premenopausal osteoporosis common symptom includes acute lower back pain due vertebral fracture predominantly occurring last trimester pregnancy immediately postpartum exact mechanisms risk factors still unknown date published systematic analyses identified patients matched healthy controls according age region evaluate risk factors large homogenous population women baseline characteristics anthropometric data two study groups similar eighty eight percent patients suffered one fractures mean fractures per patient common fracture site spine whereas patients reported fractures respectively patients suffered frequently excessive dental problems childhood control group performed significantly frequently sports puberty compared controls patients reported twice often severe diseases pregnancy frequency immobilization twice often group compared control group results indicate heterogeneous rare severe disease including substantial number fractures significant delay first symptom diagnose increased awareness warranted immediately start effective treatment
purpose project examine emotional health wellbeing canadian caregivers persons significant mental health problems assessed emotional health caregivers care receiver condition type mental health physical health problems levels caregiver stress methods particularly reducing stress among caregivers persons mental health disorders weighted cross sectional data general social survey caregiving care receiving modelled using weighted descriptive logistic regression analyses examine levels stress emotional health caregivers care receiver condition type caregivers persons mental health problems likely report caregiving stressful felt depressed anxious isolated short irritable caregiving responsibilities results study suggest mental health caregivers experience disparate stressors require varying services supports relative caregivers persons physical health conditions
prostate cancer pca second leading cause cancer death men however reliable tools detection localization still lacking dynamic contrast enhanced ultrasound diagnostic tool suitable analysis imaging injected localization angiogenic associated development tumors particular interest recently methods analysis convective dispersion process shown promise localize angiogenesis however independent estimation dispersion possible due ambiguity convection dispersion therefore study propose new method considers vascular network dynamic linear system whose impulse response locally identified end model based parameter estimation employed permits extraction apparent dispersion coefficient velocity number system clinical evaluation using data recorded patients shows proposed method applied effectively able locally characterize yielding promising results receiver operating characteristic curve area prostate cancer localization elsevier rights reserved
developing automatic system requires robust detection exact location crop protected damage computer vision techniques effective means determining plant location paper novel algorithm based colour features morphological erosion dilation proposed process segments crop regions image soil natural illumination partially proposed algorithm uses colour space discriminating crop soil region interest roi defined filtering channels certain values minimum maximum threshold values region refined using morphological erosion dilation process moment method applied determine position mass distribution objects video sequences track crops performance algorithm assessed comparing obtained results ground truth methods manual annotation sensitivity precision achieved elsevier rights reserved
purpose labor thought positively influence immune system development offspring studies investigating impact different modes delivery maternal immune system cells scarce therefore aim study investigate effect labor maternal peripheral blood cell subsets recently described regulatory cells methods cross sectional study comparing absolute counts percentages peripheral blood cell subsets maturation activation profiles regulatory cells healthy pregnant women delivered newborns via elective labor spontaneous vaginal delivery labor cells characterized using flow cytometry results found compared women elective spontaneous vaginal significantly lower absolute counts cells median cells interquartile range iqr iqr natural killer like like cells median cells iqr iqr peripheral blood significant differences particularly regulatory cells identified study groups conclusion labor seem major impact maternal peripheral blood cell subsets regulatory cells
social media platform provided oncology community unprecedented novel methods interpersonal communication increased ability dissemination important updates rapidly moving field advent subsequent success disease specific communities enabled interested healthcare stakeholders become quickly organized around unique set rare medical conditions hematologic malignancies historically generally lack large amounts reliable online information one example community myeloproliferative neoplasms social media started approximately one half years ago served recognized discussion among many members mpn community including patients researchers providers advocacy organizations article focus understanding impact community via analysis advanced metrics user experience first year use novel healthcare
computing recently introduced core subject british schools meaning children need learn computer programming teachers prepared able deliver new curriculum many feel confident teaching formal background computer science also learning programme children need correct environment support succeed paper presents environment assist teachers delivering practical elements computing curriculum also proving engaging challenging children teachers create programming challenges pupils see progressing completion challenges students undertake challenges engaging environment displays graphical output code understanding errors encounter used teach children programme number volunteer led coding children engaged volunteers acted teachers sessions found extremely valuable educational tool
nowadays information communication technologies reached level majority people spend lot time using software regular tasks ranging games ordinary time weather utilities sophisticated ones like retail applications new way life supported internet specific applications changed image people using information communication technologies world first cycle studies educational systems also addressed justification encourages development children taking consideration design develop visual system relational databases used intuitive easy way getting immediate results new database querying experience thus paper expose main characteristics features visual database showing works used execute current data manipulation operations database
play pivotal function many metabolic pathways impaired impact human health review analyzes several experimental clinical investigations regarding involvement class molecules physiological pathological situations major focus thyroid central issues relationship thyrotropin tsh signaling one hand autoimmunity hand issues consequences receptors ones tsh insulin insulin like growth factor igf connection serum tsh concentrations insulin resistance also covered insulin resistance metabolic syndrome disorders diabetes ovary syndrome autoimmunity certain malignancies reciprocal links promising therapeutic potential appreciation pathways involved certain disorders mentioned review stimulate researchers additional therapeutic applications
paper improved auto scaling variable step size maximum power point tracking method photovoltaic system proposed achieve simultaneously fast dynamic response stable steady state power first improvement made step size scaling function duty cycle controls converter algorithm secondly proposed address wrong decision made change irradiation proposed auto scaling variable step size approach compared various approaches literature classical fixed step size variable step size recent auto scaling variable step size maximum power point tracking approaches simulation results obtained matlab simulink given discussed validation elsevier rights reserved
background radiotherapy head neck cancers causes alteration oral mucosal barrier predisposing colonization infection infections often result pain burning sensation thus contributing major morbidity objective identify fungi isolated patients undergoing radiotherapy determine antifungal susceptibility week colonization find association oral fungal infection severity oral materials methods study done patients treated concurrent three samples urine blood collected fungal culture sensitivity samples collected start radiotherapy radiotherapy week post radiotherapy week results patients available analysis fungal infection found patients non albicans candida isolated candida albicans cases isolates sensitive maximum isolation yeast week radiotherapy grade grade oral found patients positive fungal infection conclusion spectrum fungal species non albicans candida candida albicans observed patients respectively higher rate fungal colonization infection found patients grade oral prophylactic patients concurrent potential reduce emerging invasive fungal infection associated morbidity national cancer institute university production hosting elsevier open access article license
many cities around world reached critical situation comes energy water supply threatening urban sustainable development engineering architecture perspective mandatory design cities taking account energy water issues achieve high living sustainability standards aim paper develop optimization model planning residential urban districts special consideration water harvesting integration optimization model multi objective uses genetic algorithm minimize system life cycle costs maximize water harvesting reliability dynamic simulations developed model used spatial optimization design new urban districts also employed analyzing performances existing urban districts energy water economic viewpoint optimization results show reliability hybrid based power system vary depending scenarios considered regarding built environment area cases concerning overall electric load cost electricity vary maximum water harvesting system reliability vary depending built environment area distribution cost water kept making competitive network water elsevier ltd rights reserved
island nations south pacific facing number pressing environmental concerns including solid waste management coastal pollution provide baseline information presence concentration heavy metals selected organic contaminants pesticides coastal streams surface waters adjacent landfill american sampled stream sediments contained high concentrations lead several coastal stream waters showed relatively high concentrations phthalate pesticides chronic toxicity values fish aquatic organisms environmental protection agency since detected several stream sites increased monitoring initiatives limit non point source land based pollution greatly improve state freshwater coastal resources reduce risks human health american elsevier ltd rights reserved
background aims low testosterone common men cirrhosis associated increased mortality whether testosterone therapy cirrhosis improves muscle mass outcomes unknown methods conducted month double blinded placebo controlled trial testosterone men established cirrhosis low serum testosterone total testosterone nmol free testosterone single tertiary centre body composition assessed using dual energy ray absorptiometry baseline months results study completion lean mass significant higher testosterone treated subjects mean adjusted difference secondary outcomes included substantially higher total lean mass active group matched reduced fat mass total bone mass increased bone mineral density femoral neck points higher testosterone therapy percentage lower mortality non significantly lower testosterone treated patients increase adverse events testosterone treated subjects conclusion testosterone therapy men cirrhosis low serum testosterone safely increases muscle mass bone mass reduces fat mass first evidence based therapy cirrhosis thus requires larger scale investigation potential impact mortality lay summary low testosterone muscle associated increased risk death men severe liver disease administering testosterone men liver disease low testosterone levels significantly increases muscle mass addition testosterone non muscle beneficial effects able increase survival population european association study liver published elsevier rights reserved
background aims data deficits lean body mass total body skeletal muscle mass anorexia nervosa scarce inconsistent furthermore usefulness reported body mass index bmi severity cut tested respect important parameters study two aims namely study patterns adult females weight restoration examine clinical usefulness bmi cut assessing protein status terms patients methods body composition measured dual energy ray absorptiometry dxa weight gain adult female inpatients controls matched post treatment bmi age patients stratified two groups using bmi cut results weight restoration patients displayed lower lean extremity mass percentage higher significant differences respect controls moreover time subgroup interaction significant terms meaning changes occur different manner time two subgroups however differences found two subgroups either demographic eating disorder characteristics weight gain normalization lean extremity mass percentage achieved across entire sample bmi subgroup fat mass major determinant gain higher baseline greater increase conclusions results suggest bmi cut clinical threshold determining severity short term weight restoration associated normalization appears biological regulation weight gain remains intact unaffected severity malnutrition elsevier ltd european society clinical nutrition metabolism rights reserved
paper deals measurement evaluation electromagnetic noise generated induction electric motor fed inverter controlled pwm suggests describes possible method evaluation electromagnetic noise used real time applications
background growing evidence emphasizes relevance metabolism immunity antigen presenting cells key players balancing responses immunology contrast known prominent effects phosphate lymphocyte trafficking modulatory effects fully characterized methods frequencies activation profiles dendritic cell subtypes monocytes cell subsets multiple sclerosis patients evaluated prior undergoing treatment months impact maturation activation profile pro inflammatory cytokine release capacity assessed vitro vivo modulation dependent programming naive cells cell proliferation also investigated vitro vivo results increased peripheral count monocyte frequencies remained stable cell count decreased ratio treg significantly increased treated patients time inhibited upregulated dcs incubation presence associated reduced release pro inflammatory cytokines dcs monocytes vitro vivo also inhibited capacity monocytes demonstrated reduced potential induce interferon gamma expressing expressing cells dependent cell proliferation vitro treated patients conclusions present first evidence directed therapies act additionally decrease pro inflammatory capabilities crucial element dependent cell activation programming
excessive plastic waste river water pollution never environmental problems faced every country around world paper polymeric membrane synthesized plastic waste high density polyethylene type treat contaminated river water plastic waste powder different particle sizes synthesizing membrane sintering method membranes synthesized without addition solvents heating temperature membrane synthesis also study membrane performance terms percentage rejection flux membrane produced average particle size achieved highest rejection highest heating temperature degrees field emission scanning electron microscopic analysis showed membranes exhibit porous asymmetric structure meanwhile fourier transform infrared spectroscopy ftir analysis membranes grouped compounds press rights reserved
group dynamics play important role social interactions children adults large amount research shown merely allocated arbitrarily defined groups disproportionately positive attitudes toward ones group negative attitudes toward groups biases emerge early childhood important empirical questions far reaching theoretical applied significance robust inter group biases biases mitigated behaviors known bond individuals groups together bonds across existing group explore questions examined bonding effects interpersonal minimally constructed groups controlled experiment group group bonding assessed using questionnaires administered task groups performed movements either non participants design also developed implicit behavioral measure island game physical proximity used indirect measure interpersonal self report behavioral measures showed increased bonding groups synchronous movement bonding group significantly higher condition movements performed movements performed non groups findings discussed terms importance developmental social psychology group dynamics implications applied intervention programs
strategy growing online biochemistry courses presented based successes state university four free drawing key videos online free course content open educational resource free easy set educational known metabolic international union biochemistry molecular biology
cystic fibrosis patients suffer chronic lung inflammation inflammation activate platelets limited data role platelet secreted cytokines platelet cytokines inflammatory effects include vascular endothelial growth factor vegf transforming growth factor beta tgf beta levels cytokines greater serum plasma due platelet release serum levels one index platelet content specific index release aggregation isolated platelets postulated altered release platelet cytokines occurs obtained sera plasma outpatients healthy controls measured vegf tgf beta assessed correlations platelet number analyzed cytokine release platelet aggregation collagen analyzed differences maximal platelet aggregation platelet number maximal aggregation levels higher plasma serum levels tgf beta vegf higher levels similar adjusting platelet number serum cytokines correlated platelet count release vegf tgf beta aggregation decreased platelets respectively platelet release source elevated blood proinflammatory cytokines tgf beta vegf platelets patients actually release less cytokines data provide evidence platelet defects
high rates epidemic mortality less developed countries challenge health facilities necessary epidemiological surveillance strengthen capacity epidemiological surveillance paper focuses remote sensing satellite data processing using data mining methods discover risk areas epidemic disease connecting environment climate health satellite data combined field data collected set periods order explain causes epidemic evolution one period another relation environment existing technical algorithms processing satellite images mature efficient challenge today provide suitable means allowing best interpretation obtained results focus supervised classification algorithm process set satellite images area different periods novel research methodology describing pre treatment data mining post treatment proposed ensure suitable means transforming data generating information extracting knowledge methodology consists six phases acquisition information field epidemic satellite data acquisition selection transformation data data derived images remote sensing measurements discretization data data treatment interpretation results main contributions paper establish nature links environment epidemic highlight risky environments public awareness problem prevention policies necessary mitigation propagation emergence epidemic allow national governments local authorities public health officials effective management according risk areas case study concerns knowledge discovery databases related risk areas epidemic region west africa results generate data mining association rules indicate level river periods societal factors impact variation epidemic rate town river level high rate contamination high elsevier ltd rights reserved
purpose paper aims describe creation innovative intelligent systems optimise energy efficiency manufacturing systems monitor energy consumption using ambient intelligence ami knowledge management technologies together create decision support system innovative add currently used energy management systems design methodology approach energy consumption data processed within service oriented architecture based platform platform provides condition based energy consumption warning online diagnostics energy related problems support manufacturing process lines installation phase continuous improvement optimisation energy efficiency systems monitor energy consumption using ami technologies together create decision support system innovative add currently used energy management systems findings systems produce improvement energy efficiency manufacturing small medium sized enterprises systems provide comprehensive information energy use knowledge based support research limitations implications prototype systems manufacturing company produces chains offshore oil gas industry energy intensive manufacturing operation paper describes case study involving energy intensive processes addressed different manufacturing concepts involved manufacture chains offshore platforms system developed support online detection energy efficiency problems practical implications energy efficiency optimised assembly manufacturing processes systems produce improvement energy efficiency manufacturing systems provide comprehensive information energy use knowledge based support social implications research addresses two critical problems energy management industrial production technologies efficiently acquire provide information online energy consumption effectively use knowledge support decision making originality value research inspired need industry effective tools energy efficiency opportunities industry take energy efficiency measures mostly carried research combined ami technologies involved new uses sensors including wireless intelligent sensor networks measure environment parameters conditions process performance behaviour aspects material flow using smart tags highly flexible manufacturing temperature distribution machines information obtained correlated standard monitor energy efficiency identify problems new approach provide effective ways collect information give new insight energy consumption within manufacturing system
sleep duration progressively last years obesity increased past years several studies reported association chronic sleep deprivation long term weight gain increased energy intake due sleep loss listed main mechanism consequences chronic sleep deprivation energy expenditure fully explored sleep body weight mood behavior subjected changes however modern environment seasonal changes light ambient temperature attenuated seasonality defined cyclic changes mood behavior stable personality trait strong genetic component hypothesize attenuation seasonal changes environment produce negative consequences especially individuals seasonality women seasonal affective disorder condition common women characterized depressed mood weight gain carbohydrate winter represents extreme example seasonality one postulated functions sleep energy preservation phenomenon characterized decreased energy expenditure changes state arousal offer useful insight mechanisms behind energy preservation sleep goals article consider contribution changes energy expenditure weight gain due sleep loss review phenomena seasonality neuroendocrine mechanisms relate sleep energy expenditure body weight regulation
work presents method determine mechanical transfer functions forces acting stator teeth electrical machine surface velocities sound surfaces method allows efficient analysis drive trains target application real environment determined transfer functions used transient acoustic model simulation electrical drive trains proposed model takes care nonlinear power electronics digital control sensors tolerance geometries electrical machines real tolerance material properties model validated means vibration measurements benefits closed simulation time domain applications proposed model discussed potential acoustic evaluation design process electrical machine illustrated
cofactor free promote control reactivity limited chemical tools disposal mechanism action completely understood structural information available reaction intermediates near atomic resolution supported raman spectroscopy calculations showed cofactor free catalyzes uric acid degradation via hydro peroxide intermediate low ray doses break specifically intermediate bond thus releasing trapped substrate radical dose dependent rate bond rupture followed combined raman analysis indicates radiation starts peroxide decomposition regeneration peroxidation explained mechanism substrate radical superoxide transiently produced active site
group signature scheme method allowing member group sign message behalf group group charge adding group members ability reveal original event based controlled quantum three particle states propose new quantum group signature scheme designated receiver security analysis proves proposed scheme possesses characteristics group signature usual attacks compared previous proposed schemes scheme follows security definition group signature fully meets basic requirements
reproductive interference known occur morphologically similar species females males produce female offspring reciprocal produce male offspring details reproduction process remain largely unknown article investigated vesicles females molecular identification hybrids based internal transcribed region nuclear ribosomal rna rrna times similar yet females males exhibited extremely low female offspring hand reciprocal produced viable sterile female offspring showed female biased offspring sex ratios females females tested males vesicle females males pairs neither vesicles one pair vesicles occurred enabled production female offspring polymerase chain reaction products region rrna gene digested exhibited two fragments single fragment whereas three fragments hybrids confirming identification results confirmed asymmetric reproductive interference demonstrated female offspring produced sterile hybrids
improvement noise performance transconductance using positive feedback approach bulk driven operational amplifier proposed paper cmos technology supply voltage reduce turn demands reduction threshold voltage overcome barrier threshold bulk driven technique good non conventional approach require modification existing structure limitation bulk driven approach transconductance operational amplifier get reduced almost three four times thanks loop positive feedback resulting transconductance boosted higher value thus increasing voltage gain decreasing input referred noise concept positive feedback used design low voltage low power building blocks operational amplifier using standard cmos technology though amplifier designed power supply also capable operate supply less simulation carried using tools technology
cases fungal infection rapid species identification crucial provide adapted therapy thereby ameliorate patient outcome currently commercial kit sodium sulfate sds method coupled mass spectrometry commonly reported protocols direct identification fungi positive blood culture however performance two protocols never compared clinical samples accordingly performed two step survey two distinct panels clinical positive blood culture identify efficient protocol establish appropriate log score cut validate best method first compared performance sds protocols clinical samples samples mass spectrometry values significantly higher sds protocol method especially best score four deposited spots considered next established cut accurate identification based specimen dna sequence data using cut isolates correctly identified species level sds protocols respectively second arm survey validated sds protocol additional panel clinical samples ninety two samples correctly identified species level median overall data suggest sds method yields accurate species identification protocol
multiple sclerosis autoimmune disease affects hundreds thousands people world wide given autoimmune nature disease large part research focused cells however research involvement myeloid cells pathophysiology received strong renewed attention recent years despite multitude inflammatory mediators involved innate immunity select group cytokines critical development cns autoimmunity among interleukin importance system experimental autoimmune encephalomyelitis recognized years recently begun understand plays multifaceted roles disease initiation development amplification review recent findings showing implication system introduce model highlights beta macrophage colony stimulating factor csf interacting together create feedback cycle cns inflammation ultimately leads myelin neuronal damage elsevier inc rights reserved
control wind power plant operating isolated power source analyzed plant consists wind turbine three phase synchronous electric generator connected means gear box mathematical models wind turbine electrical generator indicated use estimator based adaptive fuzzy logic control technique govern system proposed results control test case shown order demonstrate reliability proposed control technique elsevier science ltd rights reserved
high metabolic activity low levels antioxidant enzymes make neurons particularly prone damage reactive oxygen species thus repair oxidative dna damage essential normal brain function base excision repair major pathway repair oxidative dna damage initiated dna recognizing removing damaged base mammalian cells least five different dna overlapping substrate specificity remove oxidative dna base lesions report mrna expression distribution five dna human rodent brains using situ hybridization northern blotting supported activity assays showed widespread expression ages situ hybridization studies mouse brain showed expression increased age newborn mouse brain revealed discrete expression pattern brain regions known stem cell populations zone migratory stream region hippocampal formation expression decreased age old mice brains detected layer constitutively expressed lifespan northern expression showed transient decrease followed increase weeks age assays dna activity revealed increased activity level age brain regions analyzed
present work reports direct numerical simulations round jet onto rotating heated disk confined rotor stator cavity geometrical characteristics system correspond experimental set developed heat transfer study rotor stator system air gap axial inflow applied thermal engineering aspect ratio cavity spacing rotor radius fixed corresponding narrow gap cavity axial reynolds number red based jet characteristics also fixed rotational reynolds number omega vary preserve parameter proportional omega effects rotor periphery balanced flow along stator patterns develop stator boundary layer corresponding instability flow rotating stationary disk journal fluid mechanics cavity numerical results found agree particularly experimental data terms distribution local number along rotor finally correlation averaged value proposed according parameter elsevier inc rights reserved
objective previous studies indicated suicide rates significant seasonal variations seasonal temperature solar radiation due season south korea investigated seasonality suicide assessed association climate variables south korea method suicide rates obtained national statistical office south korea climatic data obtained korea meteorological administration period conducted analyses using generalized additive model first explored seasonality suicide climate variables mean temperature daily temperature range solar radiation relative humidity next identified confounding climate variables associated suicide rate estimate adjusted effect solar radiation suicide rate investigated confounding variables using multivariable results suicide rate showed seasonality pattern similar solar radiation found suicide rate increased times solar radiation increased adjusting confounding climate factors conclusion solar radiation significant linear relationship suicide adjusting region climate variables time trends
objective compare parent reported feeding difficulties nutritional adequacy children autism spectrum disorders asd age socio economically matched group typically developing children methods scores childrens eating behavior inventory three day food records anthropometric measures adequacy micro macro nutrients compared children diagnosed asd typically developing children enrolled department pediatrics tertiary care teaching hospital north india results majority parents asd children reported concern regarding feeding behavior compared parents typically developing children compared controls asd children significantly higher scores feeding problems relative controls asd children consumed fewer number food items particularly fruits vegetables proteins significantly lower daily intake potassium copper although children autism differ significantly controls intake height weight body mass index significantly greater proportion asd children failed meet estimated average requirement vitamin copper conclusions findings underscore need comprehensive assessment empirically supported interventions eating problems dietary deficiencies found asd children
laser therapy therapeutic role various medical conditions recently gained interest non hormonal treatment syndrome menopause non invasive option stress urinary incontinence several therapies available alleviate symptoms including hormonal non hormonal products fractional laser non vaginal laser induce morphological changes vaginal tissues data non randomized clinical trials suggest laser therapy alleviate vaginal reported improve vaginal although large randomized trials reported evidence suggests offered safe efficacious alternative hormone replacement therapy first line treatment mild moderate surgical procedures randomized studies needed compare laser treatments therapies assess duration therapeutic effects safety repeated applications research presently evaluating automated robotic probe treatments probe treatment severe type iii elsevier rights reserved
mapping enables characterization allergen epitopes development diagnostic therapeutic approaches present study display peptide library used mapping based binding antibodies recombinant group allergen house dust mite der causes indoor allergies worldwide three monoclonal anti der antibodies used seven identified common analyzed combination predicted epitopes amino acids identified key residues conformational epitopes der therefore seven modification key amino acids facilitate development blocking antibodies epitope specific mite allergy
rare manifestation skeletal tuberculosis paediatric population clinical diagnosis often delayed local symptoms easily missed children constitutional features loss weight loss appetite night evening rise temperature history close contact patient tuberculosis always present parents seek treatment significant swelling fingers hand children radiology fine needle aspiration help establishing early diagnosis multidrug therapy curative
life know heavily relies biological catalysis fact version life considered series chemical reactions regulated principles thermodynamics ancient times heart good sign vitality however actually presence active enzymes counts though usually pay attention history enzymology old dates back ancient times paper dedicated early moments remarkable science lives past make life lot efficient future almost always delicate fundamentally essential relationship enzymes challenged hostile nature full men soon discovered medicinal properties plants trial error fact discovered enzyme inhibitors thus crude terms area research plant derivatives acted enzyme inhibitors helped men pursuit survival protection later history underlying purposes survival increasing quality life stayed intact ways means enzymology experienced massive transformation trial error methodology now replaced rational scientific theories
purpose investigated improvements overactive bladder symptoms depressive symptoms treatment overactive bladder patients without depressive symptoms methods performed prospective study patients diagnosed overactive bladder july june based beck depression inventory questionnaire test subjects divided group without depressive symptoms points group depressive symptoms points patients administered months following outcomes analyzed first visit weeks weeks overactive bladder symptom score international prostate symptom score patients perceptions bladder beck depression inventory results total patients participated patients completed study outcome measures showed improvements groups weeks especially group questionnaires showed significant improvements baseline week indicating effective treating overactive bladder symptoms group group total statistically significant decreases beck depression inventory score baseline weeks observed group group group week week conclusions overactive bladder patients depressive symptoms help improve quality life depressive symptoms time
religious spiritual aspect anonymous philosophy present greater barrier patients professionals europe united states new research suggests clear advantages prescribed step behaviors practices clinicians europe open voluntary recovery resource
background although individuals experience successful weight loss following gastric bypass weight concern composition documented aim evaluate changes body composition strength measure functional status participants previous year post longitudinal study undergone approximately years prior methods five women original larger cohort monitored pre months months year years post body composition assessed time points using dual energy ray absorptiometry multiple dilution strength measured using digital hand scientific instruments ltd japan results mean time final follow years lean soft tissue loss similar year period average compared year post year lower fat free mass decreased year period mean fat mass decreased pre year post toward increase year years post loss correlated loss strength conclusion continued loss lean mass associated decreased strength occurring long term trend toward post concerning loss functional strength carries particular implications aging bariatric population investigated
paper proposes new mutated hybrid algorithm improve overall system stability optimizing gain parameters active reactive power control distributed energy resources microgrid system comprehensive optimization entire conditioning gain parameters studied terms error function minimization photovoltaic system battery energy storage proposed one microgrid system used auxiliary power supply improve link stability voltage source converter second order based considered grid synchronization der diesel engine approximation based control incorporated proposed microgrid low voltage weak microgrid considered confirmation increased stability limits computer simulations using matlab stability limits studied terms dynamic performance active reactive power dynamic relations order feedback system system studied validation stability various case observations presented including microgrid operational solar irradiation deviations performance evaluation elsevier ltd rights reserved
last years seen explosion availability ownership use devices used access internet simultaneous increase number people viewing child abuse images ease access material online removed key inhibitor offenders technology facilitated distribution child abuse images also used prevent identify offending manage offenders range technological tools currently used england manage offenders accessing child abuse images living community specific computer situation crime article analyses evidence base article concludes tool features contribute management internet child sex offenders none yet proven effective copyright john wiley sons ltd key practitioner messages technology help manage risk posed internet child sex offenders developing offer promise none technological tools proven effective management tools internet child sex offenders managers police services robust evaluations types technology offenders needed
instead classical rich scientific results survived emphasizing contribution underpinning determination energy associated definition novel terms characterization equilibrium background processes impact kinetic data evaluation less important findings resolution impact heat inertia often effect influential kinetics known since newton cooling law attempts improve thermodynamics kinetics
minimal information sexual health provision mass gathering events aim describe use sexual health contraceptive sex worker sexual assault services london analysed data five sources one contraceptive service provider reported increase attendance main games emergency contraception prescriptions rose main compared week similar lower beginning end summer period health telephone advice line reported fall sexual health related calls main increase subsequently london sexual assault referral centres reported sexual linked service sex workers reported started working sex industry moved london work fifty eight per cent sex workers reported fewer clients increase police crack respectively results show change activity across services summer associated data guide services changes service activity planning mass gathering events
aspergillus fusarium primary causative agents results corneal tissue damage leading vision loss particularly individuals tropical parts world proteins tear film collected control patients compared total proteins control proteins patient tear identified mass spectrometry proteins found patient tear control tear tear proteins showed alterations glycosylation pattern infection complement system proteins proteins specific neutrophil extracellular proteins involved healing found patient tear presence innate immune system proteins tear film patients supports previous data indicating involvement neutrophil complement pathways antifungal defense high levels wound healing proteins patient tear implied activation tissue repair infection early appearance host defense proteins wound healing response indicates tear proteins used early marker system monitoring progression pathogenesis identification negative regulators defense pathways tear indicates intricate balance pro anti defense mechanisms operating fungal infection eye significance tear proteins control patients separated non proteins identified mass spectrometry tear proteins patients showed alteration glycosylation pattern indicating alteration glycosylation machinery due infection neutrophil extracellular specific proteins complement pathway proteins wound healing proteins found patient tear showing activation antifungal defense patient tear negative regulators defense pathways also found patient tear indicating fine balance pathogen clearance host tissue destruction fungal infection depending upon individual specific host pathogen interaction understanding used predict progression outcome infection elsevier rights reserved
initial value problems nonlinear ordinary differential equation appear many fields engineering science particularly studies electrical circuits chemical reactions wave vibration research standard analysis method hybrids laplace transform method solve nonlinear differential equations using modification problems solved successfully yield good solutions examples examined highlight convenience effectiveness
potential poly lactic acid carriers vascular endothelial growth factor vegf demonstrated previous study group found improved angiogenesis heart remodeling rat myocardial infarction model however observed accumulation macrophages around injection site suggested efficacy treatment reduced due particle aim present study decrease particle consequently improve protein delivery using stealth technology prepared double emulsion solvent evaporation method using total recirculation one machine system uptake studies monocyte macrophage cells lines raw characterization developed carried terms particle size encapsulation efficiency protein stability residual poly alcohol vitro release suitable size injection obtained varying composition formulation conditions high encapsulation efficiency minimal residual content importantly bioactivity protein fully preserved moreover released phosphate buffer protein within reaching plateau within first day vitro study finally use coated peg resulted significantly decreased uptake carriers macrophages compared non shown flow cytometry fluorescence microscopy basis results concluded loaded vegf used delivering growth factors elsevier rights reserved
mothers children often experience negative outcomes following unintended pregnancies current study examined conditions unintended pregnancy associated negative outcomes among sample first time mothers recruited part predicting preventing child neglect teen mothers study specifically maternal demographic characteristics examined moderators association pregnancy intention parenting behaviors children months old results revealed unintended pregnancy associated fewer positive parenting behaviors however maternal race education moderated association among mothers identified black hispanic intended get pregnant less likely demonstrate positive parenting behaviors less education tended demonstrate fewer positive parenting behaviors regardless pregnancy intention implications research prevention intervention discussed
symmetry breaking problems among studied field distributed computing yet fundamental questions complexity remain open article work local model input graph underlying distributed network identical study randomized complexity four fundamental symmetry breaking problems graphs computing miss maximal independent sets maximal vertex sets small sample results includes following mis algorithm running log delta root time delta maximum degree first mis algorithm improve algorithms log delta root log comes close omega log delta log log delta lower bound maximal matching algorithm running log delta log log time first significant improvement algorithm israeli moreover dependence delta nearly optimal delta algorithm requiring log delta root time improving log delta root time algorithm method reducing symmetry breaking problems low graphs low degree graphs roughly speaking graph bounds density reduction include root log time maximal matching algorithm graphs root log log time mis algorithm graphs log algorithms based simple powerful technique reducing randomized symmetry breaking task corresponding deterministic one poly log size graph
estimation marginal partial effects covariates various conditional parameters often main target applied analysis specific context models estimation partial effects involving outcome probabilities often interest estimation straightforward univariate models results covering case probability marginal effects bivariate models jointly distributed outcomes previously described literature papers goals extend results encompass general multivariate context arbitrary probabilities extended results models condition multivariate ordered data structures suggested partial effects broadly useful situations wherein multivariate outcomes concern
purpose childbearing age progressively increased countries impact delay however requires research methods study sample included prospective cohort healthy pregnant women aged years assessed weeks gestation time birth time months birth time effect age psychological biological social variables evaluated maternal psychological symptoms terms depression anxiety assessed parenting stress stress biomarkers cortisol alpha determined mothers questionnaires addressing social functioning family functioning maternal attitudes social support conducted bayesian additive models used analyze data results depressive symptoms showed steep increase starting years age shaped relationship minimum around years old results observed parenting stress cortisol levels increased sharply years age family functioning maternal attitudes social support improved moderately years age conclusions prenatal depressive symptoms higher older women postpartum depressive symptoms parenting stress increased younger older women nevertheless cortisol levels just increased older ages postpartum contrast social functioning family functioning maternal attitudes social support improved age conclude social advantages compensate disadvantages delayed childbearing depressive symptoms parenting stress high cortisol level elsevier ltd rights reserved
paper new low power low noise operational amplifier dedicated implantable biomedical applications introduced amplifier designed minimize input referred noise power thermal noise use model set bias currents transistors noise transistors large gate areas operating weak inversion used noise switched applied involves switching transistor periodically inversion region helps reduce noise transistors use switched allows noise increase current thus allows avoid problem trading power noise using able achieve extremely low input noise rms desired bandwidth small additional circuitry required switched consumes minimal power average power amplifier makes ideal implantable applications gain amplifier required frequency range phase margin degrees greater frequencies circuit designed using tsmc process analog design environment cadence performance circuit studied process namely simulations carried degrees normal human body temperature
although appearance based cues help diagnose physical illness visual manifestations mental disorder elusive investigated whether individuals distinguish women serious mental disorder borderline personality disorder matched non psychiatric controls participants rated mentally targets likely mental disorder photos accurately chance despite judgments possible configuration facial cues played important role judgments interfering spatial relationships facial features reduced participants accuracy chance investigation showed similar results participants rated targets specific mental disorders borderline personality disorder major depressive disorder rated mentally targets depressed angry anxious emotionally unstable less happy moreover depression ratings significantly correlated targets actual depressive symptoms thus individuals able infer aspects mental disorder minimal facial cues
background amygdala large grey matter complex limbic system contribute pain network migraine however detailed remained elucidated objective study investigate amygdala structural functional changes migraine elucidate mechanism pain modulating migraine pathogenesis methods conventional mri structure images resting state functional mri performed normal controls patients episodic migraine patients chronic migraine amygdala volume measured using software functional connectivity bilateral amygdala computed whole brain analysis covariance performed individual maps among groups results increased left amygdala observed compared decreased right amygdala revealed compared increased bilateral amygdala observed compared correlation analysis showed negative correlation score sleep quality normal mild sleep disturbance moderate sleep disturbance serious sleep disturbance increased strength left amygdala compared positive correlation score sleep quality increased strength left amygdala compared clinical variables showed significant correlation altered amygdala conclusions altered functional connectivity amygdala demonstrated pain network contribute pathogenesis
question subject article intended statistical question practice todays question nature mathematics specifically method mathematics since mathematics problem solving expression view method mathematics analytic method mathematics theorem proving expression view method mathematics method article argued two views mathematical method really opposed order answer question whether mathematics problem solving theorem proving article origins question answer argues results reasons view mathematics problem solving
new academic center achieved leed platinum rating first core campus meet green building criteria given design largely influenced historic preservation interest maintaining views historic valuable campus green space drivers led comprehensive design process alignment long term goals overall campus first phase initiative grade classroom addition provides new space law school programs energy efficient building concurrent environmental benefits including preservation open space enhanced storm water management addition addition building project emphasized use existing local building materials
aim study evaluate occurrence pigs human consumption state brazil blood tissue samples liver heart brain lung collected pigs legal tested infection antibodies found sera using immunofluorescence antibody test cut tissue samples seropositive pigs mice tissue samples seropositive pigs mice submitted histopathology immunohistochemistry polymerase chain reaction pcr sequencing pig tissue samples mouse samples positive dna pig mouse tissues negative histopathology analysis using risk assessment questionnaire significant difference pig data serve indicative conditions risk infection pigs preventive measures implemented health services avoid human cases due ingestion pig meat
background collective cell migration whereby cell cell contacts cadherin maintained migration recently emerged detailed mechanisms still unclear study role functions recycling relationship cadherin colorectal carcinoma identified role collective cell migration colon cancer cells clarified materials methods total patients surgically colorectal carcinoma enrolled immunohistochemical study relationships overexpression cadherin survival evaluated cell biology overexpression knock colon cells studied results expression cadherin correlated stage cancer lymph node metastasis however overall survival poor group patients positive expression compared group patients without dual positive expression demonstrated physical interaction cadherin overexpression found promote collective cell migration increased distribution cadherin enhanced cell cell connections addition activation matrix metalloproteinase expressions upregulated upon expression conclusions study demonstrated cadherin expressions indicators poor survival time colorectal carcinoma overexpression contribute increased collective cell invasion colorectal carcinoma
high concentration equipped high efficiency solar cells great potential achieving cost effective clean electricity generation utility scale systems complex compared conventional effect present modelling power output systems therefore crucial market penetration following line modelling procedure high concentration presented work combines open source spectral model single diode electrical model finite element thermal model order validate models modelling procedure actual data outdoor experimental campaign conducted new mexico using high concentration photovoltaic thoroughly described terms geometry materials experimental results good agreement within predicted maximum power point approach relatively complex compared empirical models besides overall performance prediction also provide better understanding physics involved conversion solar irradiance electricity therefore used design optimisation high concentration photovoltaic modules elsevier ltd rights reserved
methods study based semi structured qualitative interviews policy makers senior health care managers two russian regions review published sources health systems hiv russia findings identified number factors associated systems failure address epidemic argue factors unique hiv aids features wider health system within hiv response set influenced structure capacities programme particularly regulatory clinical orientation discrepancy formal implementation focus screening services problems scaling interventions targeting high risk groups discussion system programme interplay important middle income countries poorer settings advanced health care infrastructure protect health systems potential failures delivery vertical programmes hiv response effective efficient responsive needs population broader health system adhere principles strengthening hiv responses post societies require improvements wider health systems namely advocacy prevention high risk populations resources curative towards preventive services building decision making capacities local level developing better working environments health care staff
planning layouts management major impact performance tunnel construction projects use tunnel machines frequently projects reach highest possible production performance due processes insufficient storage capacities paper flexible simulation framework analyzing interactions production processes tunneling presented formal ontology logistic elements tunneling developed using formalism based formulation single systems elements combined process chains analyzed influence production processes evaluated formal system description identifies process dependencies resource constraints system elements formulations implemented configurable simulation components construction equipment storage spaces production materials using components simulation model created layout represented high level detail geometric shapes used estimating storage capacities movement durations approach uses discrete event system dynamic simulation applies probability functions inputs representing production process times dynamic simulation reveal unknown impacts processes continuous advance processes simulation model integrated determine demand supply processes fast effective comparison different layouts strategies possible due flexible components analyzing workload construction equipment robust efficient developed case study illustrates usefulness simulation framework comparing performance three different tunneling project american society civil engineers
merit linear nonlinear recursive filters ability represent unknown systems far fewer coefficients counterparts unfortunately nonlinear recursive filters become general unstable large amplitudes input signal paper introduce novel linear parameters nonlinear recursive filters whose members stable according bounded input bounded output criterion shown filters called stable recursive functional link polynomial filters universal causal time invariant infinite memory continuous nonlinear systems according stone theorem reduce filter complexity simplified structures also investigated even though simplified filters universal good performance demonstrated exploiting either data measured real systems available literature benchmarks nonlinear system identification
green vehicles electric vehicles evs getting noteworthy popularity among consumers worldwide purpose paper establish evs feasible long term solution future technology vehicle industry decrease current dependency fossil fuels also decrease greenhouse gas emissions part long term benefits adoption evs gives environmentally friendly innovation society despite positive environmental implications total number evs usage still inadequate one major causes adoption evs largely dependent perceptions consumers regarding evs however particular research study offers inclusive outline existing consumer adoption evs framework theoretical developed adoption behaviour addition considering consumer intentions direction evs particular study researcher found literature regarding adoption tried address diffusion method evs whereas study highlights consumer innovations provides wide insight consumer emotions major aspect consumer evs adoption research theme particular literature implemented order better understand consumers emotions behaviour towards adoption evs scholars stated possible cause recent developments within technological adoption part assist standard upcoming developments last years knowledge regarding problems surrounding adoption diffusion evs gained less attention study expands line research focusing making chance developing theoretical frameworks terms adding emotions psychological perspective consumer behaviour ethics considered copyright john wiley sons ltd
objective evaluate relationship serum levels metabolic syndrome mets chronic spontaneous urticaria patients methods study patients healthy volunteers included height weight waist circumference blood pressure measurements groups fasting blood sugar serum lipid levels tumor necrosis factor alpha tnf alpha levels evaluated venous blood samples metabolic syndrome mets diagnosis determined using national cholesterol education program adult treatment panel iii diagnostic criteria results mets found patients control subjects statistically significant difference two groups terms mets presence found mean serum levels patients control group statistically significant difference groups terms serum levels difference seen patients without diagnosis mets regarding urticaria activity score duration disease autologous serum skin test positivity serum immunoglobulin levels presence autoimmunity serum tnf alpha levels conclusion increased incidence mets patient group found study however difference patients without mets regarding disorder associated parameters serum tnf alpha levels
traditional korean asian medicine leaves used treat inflammatory diseases including dermatitis cough asthma recently leaves applied skin care promote skin elasticity therefore present study investigated anti aging effects leaf extract fractions results whole cell patch clamp analysis indicated extract mediated ultraviolet induced associated ion channels transient receptor potential calcium release activated calcium channel protein channel activity cells overexpressing electrophysiological analysis revealed fraction inhibited induced currents furthermore fractions inhibited activity respectively furthermore fractions inhibited activity respectively induced associated enzymes regulate skin formation respectively results present study indicated leaves novel treatment induced
cross sectional study conducted city brazil investigated association presence psychiatric disorders types crimes committed psychiatric diagnosis obtained means brazilian portuguese version mini international neuropsychiatric interview statistically significant association found psychiatric disorders specific groups crime lifelong substance addiction sex crimes antisocial personality disorder borderline personality disorder sex crimes lifelong alcohol addiction concluded mental disorders considered severe psychosis bipolar disorder associated violent crimes suggesting severity psychotic disorder factor caused psychosis associated violent crimes previous studies
present study aimed examine relationships antisocial personality disorder symptoms adulthood retrospective reports childhood maltreatment parental bonding controlling symptoms depression anxiety four hundred eleven non clinical participants males females aged years recruited australian university general public completed questionnaire package findings indicated significant associations childhood maltreatment parental bonding depression anxiety levels symptomatology hierarchical regression analysis revealed physical abuse physical neglect level father care made largest unique contributions prediction scores statistically controlling comorbid depression anxiety analysis variance revealed higher levels symptoms reported males younger participants research contributes importantly understanding factors influencing symptomatology clinical early intervention implications
background although small elevations high sensitive cardiac associated incident heart failure general population underlying mechanisms defined evaluating association replacement fibrosis progression structural heart disease symptoms fundamental understanding potential biomarker prevention strategy methods measured baseline among participants multi ethnic study atherosclerosis cohort initially free overt cardiovascular disease cvd cardiac magnetic resonance imaging performed baseline repeat cardiac magnetic resonance performed years later among participants remained free cvd events received enhanced cardiac magnetic resonance characterization replacement fibrosis late enhancement progression subclinical cvd defined year change left ventricular structure function associations incident related mortality coronary heart disease estimated using cox regression models results late enhancement replacement fibrosis detectable participants without cvd events follow cardiac magnetic resonance graded association observed higher baseline categories late enhancement versus limit detection highest category versus versus limit detection adjusted hazards ratio conclusions levels associated replacement fibrosis progressive changes left ventricular structure cvd free adults findings precede symptoms years minor elevations represent biochemical signature early subclinical cardiac disease providing opportunity targeted preventive interventions
organizations looking ways sustain incremental improvements end developed computer aided employee suggestion management system called need make problem visible support employees efforts reduce waste increase employee satisfaction human interaction technology context work challenging introduction process called designed set support transition proposed solution tested three working conditions assess relevance limitations test lasted weeks indicators tests compared reference study based non technological experimentation based similar problem solving methodology int health care doi introduction technology provided relevant qualitative quantitative results cycle time closing actions reduced compared earlier study number actions progress time also reduced earlier study leadership routine substantially increases chances introducing long term basis
blood great medical veterinary significance transmit bacteria fungi viruses causing variety human animal diseases worldwide present study intestinal bacterial flora associated different developmental stages analyzed using polymerase chain reaction pcr gradient gel electrophoresis eleven distinct bands found using pcr method sequences analyses indicated belonged bacillus pseudomonas aeruginosa staphylococcus bacterium clone find aeruginosa isolates presented different developmental stages present results indicated pathogens present province china knowledge first report intestinal bacterial flora associated china
information communication technologies applied health care advances sensor data transmission technology allowed medicine based programs care also patients respiratory diseases different sensors transmission devices interventions used medicine indications patients suffering chronic obstructive pulmonary disease asthma neuromuscular diseases assisted individuals undergoing pulmonary rehabilitation programs benefit approach legal problems still economic advantages health care systems though potentially high still poorly investigated despite need evidence modality considered real progress management patients respiratory diseases one hand technologies improve care patients difficult access services particularly rural remote areas hand risk used reduce standard services health systems developed countries
present fast memory efficient algorithm generating compact performing much common sub tree merging identical nodes ever created improve construction times several orders magnitude large data structures require much less working memory improve performance suggest two new algorithms remaining common sub trees merged also propose new set rules resolving undefined regions significantly reduces final memory footprint already heavily compressed data structure additionally examine feasibility using many local present two improvements original algorithm allow handle hundreds high quality filtered real time frame rates
number previous studies reported potential risk malignancy particularly hematological malignancy developing patients receiving metal metal hip replacement report case malignant lymphoma arose patient hip arthroplasty complicated development tumour cell follicular lymphoma involved lymph nodes bone metal ions known effect lymphoid cells although epidemiological studies established increased risk lymphoma associated implants relatively short time period since introduction type implant long term follow patients implants indicated
northeastern mexico region water scarcity strong pressure water sources caused rapid increase population region rainwater harvesting alone enough meet water supply demands due irregular distribution rainfall time space thus study reliability integrating rainwater harvesting reuse reduce water consumption minimize wastewater generation campus assessed potable water consumption generation main facilities campus determined rainwater potentially harvested roofs areas campus estimated based statistical analysis rainfall based data potential water savings wastewater minimization determined characterization rainwater carried determine treatment water source additionally capacity water storage tanks estimated selected treatment systems economic assessment conducted determine viability alternatives proposed results showed water consumption reduced wastewater generation minimized implementation rainwater harvesting reuse systems campus generate important economic benefits institution investments achieved six years net present value order internal rate return benefits investment ratio year project present greater minimum acceptable rate return decade twice economic feasibility based results clear integrating rainwater harvesting reuse resulted feasible reliable strategy strategies based rainwater harvesting furthermore investments shorter period time
communities practice received significant attention within variety literatures remain largely potential created global organisations context challenge likely convincing merits joining conversation practice distance thus making willingness exchange key quality longevity community posed question dispersed professionals want join participate year collaborative action study allowed observe membership close range conclude autonomy competence belonging underscore participation production diffusion innovative problem solving practice beyond study inform organisations similar interventions also serves basis investigation theory building organized research community elsevier ltd rights reserved
effective transconductance bulk driven operational amplifier opamp significantly vary input common mode voltage variation frequency compensation creates harmonic distortion thus brief presents stabilizing technique reduce variation across input common mode range idea use variable positive feedback structure adaptively control input common mode voltage low voltage bulk driven opamp proposed stabilizing technique implemented cmos process opamp consumes supply voltage variation reduced across rail rail measured gain unity gain bandwidth mhz opamp loaded parallel omega
provided insights factors facilitate inhibit parent infant neonatal units none specifically focused perspectives senior neonatal staff aim study explore perceptions experiences senior nurses five european countries regard issues small group discussions three one one interviews conducted senior nurses representing nine neonatal units finland norway spain sweden interviews explored facilitators barriers parent infant implications policy practice thematic analysis undertaken highlighted care agenda enabled parent infant aspiration pointed neonatal units different stages achieving facilitators barriers physical included socio economic factors cultural norms designs neonatal units resource issues leadership staff attitudes practices relationships staff parents factors affected parent infant neonatal units european countries needs political motivation appropriate policy planning legislation resource allocation increase measures support neonatal units
daily stress tendency react stress heightened levels negative affect stress sensitivity important vulnerability factors adverse mental health outcomes mindfulness based stress reduction help reduce perceived daily stress stress sensitivity purpose study examine change perceived stress negative affect decoupling perceived stress evolved course program without making priori assumptions shape change seventy one adults general population participating provided daily diary assessments perceived stress time varying effect model indicated perceived stress decreased linear fashion rather nonlinear fashion function time function cumulative number days mindfulness practice multilevel growth modeling showed association perceived stress decrease course findings support hypothesis reduces also reduces extent individuals perceive days stressful also results suggest dose response relationship amount mindfulness practice reductions daily stress
exhaled nitric oxide levels asthma suggested inducible synthase inos aim study investigate expression inos bronchoalveolar lavage cells tissue central peripheral airways compare exhaled bronchial alveolar levels patients asthma control group two patients asthma defined controlled uncontrolled according asthma control test score cut eight healthy controls included exhaled measured alveolar concentration bronchial flux calculated inos measured central peripheral lung biopsies cells bronchoalveolar lavage macrophages stimulated vitro inos expression production investigated inos increased central airway tissue alveolar compartment uncontrolled compared controlled healthy controls differences however inos mrna levels total cells uncontrolled compared controlled asthma bronchoalveolar lavage cell mrna levels inos inos expression central alveolar tissue relate alveolar bronchial flux vitro stimulation increased inos mrna levels production cultured macrophages conclusionthe levels bronchial alveolar inos increased uncontrolled compared controlled asthma however levels inos macrophages reflected alveolar central distal inos levels reflect responsiveness steroid treatment
background biological underpinnings serious violent behaviors patients schizophrenia remain unclear aim study identify characteristics brain morphometry patients schizophrenia history serious violent acts treated relatively new legislation offenders mental illness japan relevant action strongly associated mental illness also investigated whether morphometric changes depend types serious violent actions methods thirty four male patients schizophrenia hospitalized serious violent acts compared male outpatients inpatients schizophrenia history violent acts weighted magnetic resonance imaging mri voxel based morphometry used assess gray matter volume additionally patients violent acts divided based whether relevant actions regional volumes two groups compared control patient group results patients schizophrenia history serious violent acts showed significantly smaller regional volumes right inferior temporal area expanded middle temporal gyrus temporal pole right area compared patients without history violence patients violent acts showed significantly smaller regional volumes right inferior temporal area right area left area including insula bilateral precuneus area including posterior cingulate gyrus without history violence whereas patients impulsive violent acts showed significantly smaller volumes right inferior temporal area compared without history violence conclusions patients schizophrenia history serious violent acts showed structural differences brain regions compared schizophrenia history violence abnormalities right inferior temporal area relatively common depend whether violent actions abnormalities wider range attributed planning violent action others also maintaining plan
increase mobile applications social media daily generating huge volumes data variety data shapes evolving term known big data efficiently handling big data seems challenge meet rate data growth challenge played significant role indexing also correlating events across space time big data security analytics therefore paper introduces filter space time efficient probabilistic technique variants summarized terms contributions network security domain besides variants evaluated characteristics big data security analytics conducting experiment huge volume data introduced technique along unsupervised learning engine tested results showed used overcome efficiency lacking space time indexing analyzing big data
study investigated influences transition age gender aspects daily experiences adults aged years stayed working data derived first second waves daily diary study national survey united states participants completed telephone interviews experiences across eight consecutive days findings showed significant interaction effect transition age daily stressors gender significantly moderate associations transition daily experiences findings suggest transition considered context life course influences especially age better determine quality daily experiences older adults life course influences considered programs services aimed help adults experiences
paper propose four flexibility switching exact approximate operating modes approximate mode dual quality provide higher speeds lower power cost lower accuracy level accuracy approximate mode different delays power approximate exact modes using structures parallel provides configurable whose accuracies powers speeds change dynamically runtime efficiencies bit multiplier evaluated standard cmos technology comparing parameters state art approximate results comparison indicate average lower delay power consumption approximate mode also effectiveness assessed image processing applications
introduction treat target guidelines recommend achieving remission low disease activity rheumatoid arthritis however reduction adverse events costs associated lower disease activity unclear methods used linked medicare data identify patients time varying disease activity measured using clinical disease activity index outcomes included cause hospitalization composite hospitalization emergency department visits mortality medical costs outcome specific cox proportional models evaluated adjusted hazard ratios disease activity outcomes controlling potential confounders including comorbidities grouped four patient phenotypes costs analyzed mixed models using gaussian distribution log transformation results depending outcome patients contributed person years median age years women baseline approximately patients remission low disease activity dose response relationship disease activity remission low moderate high incidence hospitalizations per respectively adjusted hazard ratios significant remission low high compared moderate disease activity similar trends observed visits mortality crude difference annual medical costs remission moderate disease activity adjusted difference conclusion leveraging benefits linking registry administrative data together lower disease activity associated reduced risks cause hospitalization visits mortality medical costs dose dependent fashion copyright john wiley sons ltd
let subset open domain fractal boundary partial derivative define proper convex lower functional space partial derivative partial derivative characterize gives rise boundary conditions consider associated nonlinear generated opposite prove corresponding abstract problem uniquely prove unique strong solution solves quasi linear parabolic problem term boundary partial derivative moreover study properties nonlinear prove order preserving end turn attention elliptic problem show existence uniqueness global weak solutions elsevier ltd rights reserved
patches serious restriction constrained strict rectangular topology means request insert single new control point cause row control points appear across patch global refinement control investigate method unwanted control points user users interaction local rather global refinement method requires straightforward modification user interface data structures represent control mesh making simpler alternatives use hierarchical constructions results show method effective many cases limitations single new control point certain cases still cause cascade new control points appear across patch authors published elsevier ltd open access article license http creativecommonsorg licenses
superoxide dismutase sod plays crucial role antioxidant responses environmental stress determine whether sod affects heat resistance cloned sod cdna sequences two strains red wild type cultivar cdna sequences contained orf encoding amino acid residues cdna sequences deduced amino acid sequences two strains shared relatively high identity intron existed genomic dna sod southern blotting indicated multiple copies possibly four sod strains wild type cultivar sod mrna transcription sod activity increased high temperature stress cultivar heat resistant based sod activity research suggests direct relationship sod activity heat resistance
urbanization globally consistently natural landscape accommodate growing human population urban vegetation plays key role moderating environmental impacts caused urbanization critically important local economic social cultural development differing patterns human population growth varying urban structures development stages results highly varied spatial temporal vegetation patterns particularly pan pacific region fastest urbanization rates globally yet spatially explicit temporal information amount change urban vegetation rarely documented particularly less developed nations remote sensing offers exceptional data source unique perspective map urban vegetation change due consistency ubiquitous nature research assess vegetation fractions cities across pan pacific countries using annual gap free landsat surface reflectance products acquired using sub pixel spectral approaches vegetation change trends analyzed using mann statistics slope estimators results successfully mapped urban vegetation pixels located urban regions agricultural land correlation coefficient ranging greatest vegetation loss found shanghai china contrast cities including canada usa showed stable vegetation trends time using temporal trend analysis results suggest possible reduce noise outliers caused changes particularly using dense new landsat time series approaches conclude simple yet effective approaches landsat time series data assessing spatial temporal changes urban vegetation regional scales provide critical information urban planners anthropogenic studies globally international society photogrammetry remote sensing inc published elsevier rights reserved
objectives non hodgkin lymphoma occurs increasing frequency hiv aids south africa highest incidence hiv aids worldwide epidemiologic study nature provides insight head neck lymphomas defined south african population retrospective review evaluated frequency pathologic characteristics patients diagnosed head neck lymphoma oral pathology department university materials methods histopathology reports patients head neck lymphomas reviewed demographic age gender clinical site size tumour laboratory histological parameters recorded results patients head neck lymphomas mean age years male female ratio cervical lymph node common anatomic site cases cases common site lymphoma cases common histologic subtype seen frequently result strong association hiv aids common lymphoma variant cases head neck lymphomas patients known hiv status lymphoma diffuse large cell lymphoma lymphoma conclusion increase head neck lymphoma frequency contrary found western countries high hiv prevalence certain lymphomas provides strong indication role hiv aids pathogenesis lymphomas study serves baseline future studies especially south africa elsevier ltd rights reserved
agriculture brazilian last four decades resulted unintended consequences increased groundwater surface water pollution due excessive fertilization address problems within coffee process based model used simulate nitrate nitrogen plant nitrogen uptake several rates effects splitting applications three times per year every day also evaluated within statistical analysis outputs showed simulated soil solution concentrations agreement experimental measurements collected entire year simulated annual uptake also agreement average measured uptake coffee plants evaluation simulation scenarios showed efficient recovery associated rates split least seven applications per year recovery rates efficient without split application iii environmentally friendly management strategy application using least seven reducing rate increased plant recovery efficiency reduced predicted plant uptake results confirm better management strategies developed coffee crops grown elsevier rights reserved
automated real time control electrical network achieved estimation state using measurement units given graph representing network study problem finding minimum number measurement units place edges graph fully observed problem also known power edge set problem variant power set problem naturally modeled using iteration indexed binary linear program whose size turns large practical purposes use fixed point argument remove iteration indices obtain compact formulation latter single level mixed integer linear program performs better natural formulation lastly provide algorithm solves program directly much faster commercial solver solve previous models also discuss robust variants extensions problem wiley periodicals inc networks vol
pathogen relevant psychiatric disorders recently showed reactivation chronic infection induced depression like behaviors mice furthermore hypothesized depression like behaviors mediated via host defense mechanism pathogens mechanisms behavioral hypothesis remain unclear present study investigate contribution inflammation interferon gamma ifn gamma related behaviors infected mice using sucrose preference forced swim tests respectively first confirmed balb mice exhibited depression like behaviors acute infection treatment infected wild type mice anti inflammatory drug like behaviors whereas infected mice treatment normalized tryptophan ratios plasma brain tissue additionally infection failed induce like behaviors increase ratio immunocompromised ifn gamma mice whereas behavior observed ifn gamma mice following infection furthermore treatment methyl tryptophan inhibitor affect locomotor activity attenuated clinical scores like behaviors resulted normal ratios infected wild type mice although low levels serotonin dopamine observed brain acute chronic infections like behaviors detected chronic stage infection collectively results demonstrated immune enhancement response infection resulted ifn gamma production activation inflammation associated like behaviors
formal language theory plays computer science fundamental role allows among things development one information technology programming languages define mandatory rules programmers need follow create tools enable humans interact machines despite significance formal language theory often taken even software developers regularly follow rules programming domain unless developer creating programming language data structure describing formal background existing one need deep formal languages theory need develop rules first understand theory formal languages limitations impose paper introduction fundamentals language theory classification restrictions representation ground rules set use worldwide known data structure format object formally define rules formal background allow transform theory bits developing algorithm analyze streams texts accepting comply predefined rules finally analyze outcomes implementation benefits limitations alternatives followed
purpose large investment resources screening fact colorectal cancer remains second leading cause cancer deaths among americans underscores need alternative strategies thus major clinical research imperative clinical care focusing risk stratification screening surveillance therapeutic factor colorectal cancer biologically heterogeneous least four consensus molecular subtypes presents clear challenges developing robust molecular purpose review discuss genetics molecular biology colonic high low racial disparities colonic finally put forth emerging concept greater genomic landscape idea chromatin protection therapy novel adjuvant chemotherapy
objective symptoms airway diseases often associated specific times day example worsening cough frequent complaint patients speculate symptoms control circadian clock clock genes airway epithelium play important roles present study tried prove time specific expressions clock oscillating genes murine materials methods adult wild type mice mutant mice used study employed northern blotting examining circadian expression results expression mrna showed strong day night expression difference abolished lesion nucleus mutant mice proteins showed similar expression profiles epithelium glands peak evening trough early morning nuclear proteins show rhythms protein showed circadian oscillation laryngeal gland conclusion study confirmed existence local laryngeal clock controlled central clock nucleus protein gland also showed circadian rhythm consider rhythmic expressions cause time specific symptoms among laryngeal diseases elsevier ireland ltd rights reserved
liquids gas commonly seen medical science natural science daily life engineering nonlinear wave symbolic computation dimensional variable coefficient model liquid performed auto backlund transformation solutions obtained respect density fluctuation bubble liquid mixture auto backlund transformation solutions depend bubble liquid viscosity transverse perturbation bubble liquid nonlinearity bubble liquid dispersion coefficient functions note shock waves given solutions observed gas bubble liquid mixture experiments effects liquid respect bubble liquid viscosity transverse perturbation bubble bubble liquid dispersion coefficient functions detected future gas bubble liquid mixture experiments
west east africa experience high variability rainfall expected increase climate change results fluctuations water availability food production socioeconomic activities water harvesting storage mitigate adverse effects rainfall variability past studies shown investments water storage guided environmental health considerations increased availability open water surface increase transmission water related diseases demonstrated associated small reservoirs malaria ethiopia around large dams small dams water harvesting ponds concern develop water harvesting storage climate change adaptation increase risk already vulnerable people cases benefits greater water availability taking health issues account participatory approach planning design management rainwater harvesting water storage considering full range water storage options enable better opportunities enhancing resilience climate change vulnerable populations sub saharan africa
purpose study verified reaching movements able quantitatively evaluate effects two three dimensional images movement healthy people addition clinical data cerebrovascular accident patients also analyzed method subjects ten healthy adult volunteers two male patients previous cerebrovascular accidents participated methods subjects reaching objects shown display target virtual limb rendered computer graphics shown display movements virtual limb synchronized subject healthy subjects reached targets dominant arm cerebrovascular accident patients used arm polarized display polarized used subjects shown three dimensional images present study cost used quantify movement results six healthy subjects significantly reaching movements viewing three dimensional images two cerebrovascular accident patients tended movements response three dimensional images conclusion analysis movement able detect influence depth cue vision movement quantitatively healthy subjects cerebrovascular accident patients
increase installed capacity renewable energy sources res positive effect development smart grids demand side management dsm reason intermittent nature renewable energy directly related problem balancing production consumption power within power system using dsm power consumption system comprising res easier adjusted power production paper proposes improved concept dsm spatial temporal dsm optimal spatial temporal dsm aims determining power diagram individual load bus order achieve optimal state whole system optimal state system quantified minimum daily energy losses minimum daily operating costs mathematical definition optimal spatial temporal dsm problem presented algorithm solution proposed methodology tested three test networks results confirm overall system performance improvements include reduction energy losses system reduction operating costs increase voltage quality within system elsevier ltd rights reserved
literature reported several factors impact quality life caregivers patients psychiatric illnesses study aimed determine level quality life among sample caregivers patients psychiatric illness two patient mental health clinics northern examine relationships sociodemographic characteristics stigma caregiver perceptions burden quality life correlational descriptive design utilized three self administered questionnaires used results indicated patients low moderate qol suffered moderate high stigma also family caregivers perceived low moderate qol patients family caregivers stigma perception correlated negatively significantly family caregivers burden correlated negatively significantly domains total qol self reported general health health care providers assure importance focusing toward minimizing stigma promoting physical general health maintain good quality life caregivers patients mental illnesses
third person effect hypothesis states people typically perceive media messages greater influence others though self perceptual bias shown robust across variety message contexts past research typically utilized caucasian college student samples current study addresses literature examining whether hypothesis holds low income low education spanish speaking female adults regard perceived effects health news coverage findings showed participants chose equal others estimating health news effects instead less others others results ordinal logistic regression showed propensity toward related bias certain indicators findings suggest need future research hispanic populations efforts investigate perspective
background aims hepatitis virus infection unclear aimed evaluate components chronic hepatitis patients methods red blood cell components serum levels relationship clinical characteristics evaluated age matched sex matched healthy controls histology proven patients results chronic hepatitis patients significantly higher serum levels log versus log lower hemoglobin concentrations versus compared healthy controls among patients serum level negatively associated concentration confidence intervals counts positively correlated activity fibrosis liver histopathology non patients severity liver activity positively correlated serum levels respectively negatively related counts using stepwise multivariate linear regression analysis grade activity positive whereas concentration inversely associated serum levels patients conclusions disease activity patients negative impact compensatory higher blunted responses
characterized infrequent sexual reproduction habit however molecular biology flower formation development studied species studied molecular regulation mechanisms development selecting three key regulatory pathways plant pathogen interaction plant hormone signal transduction protein processing endoplasmic reticulum different stages selected six micrornas involved three pathways pathway cluster analysis subcellular localization transcriptional activation western blotting hybridization qrt pcr used investigate expression patterns regulatory roles pivotal genes different flower development stages differential expression patterns showed six mirnas play vital regulatory roles flower development transition research way studies metabolic regulatory networks provides insight molecular regulation mechanisms senescence
major factors control performance reinforced soil structures interaction soil reinforcement thus necessary obtain accurate bond parameters used design structures evaluate behavior clay soil reinforced woven geotextile reinforced consolidated compression tests conducted moisture content soil pressures arrangement geotextile layers varied behavior sample examined stress strain patterns drainage modulus deformation effect confinement pressures effects moisture content evaluated impact moisture content clay critical shear parameters also studied recommend placement moisture mdd results indicate geotextile reinforced clay viable alternative reinforced soil structures good quality granular material readily available
network size grows becomes difficult understand entire network complex network theory used analyze characteristics current network trust management schemes suggested understand entire network security situation results paper reveal order solve security problem complex network reliably security policy needs established prevent hub infected
summary study explores interactions parents charged child abuse neglect drawing ethnographic observations court cases family court located northeastern united states study seeks understand encourage inhibit parents participation strategies tactics used influence parental behaviors obtain cooperation court orders findings one end spectrum engage little parents professional court actors end spectrum participatory approach parents court room exchanges engaging informational decision making similar divergence appears cooperation parents relying others using approach incorporates support applications strategic interventions identified increase parents cooperation satisfaction family court system include engaging informational decision making parents using support rather
timing introduction solid food subsequent development food allergy debate role concurrent breastfeeding unclear aim present study investigate role solid food introduction whilst concurrently breastfeeding food allergy outcome specific focus milk allergy prospectively collected infant feeding data birth cohort analysed participants histories suggestive food allergy underwent diagnostic food challenges children food allergy matched control participants age sex mann whitney tests chi fisher exact tests logistic regression calculations undertaken total thirty nine food allergic children seventy eight matched controls identified including twenty two milk allergic children forty four matched controls control group introduced solid food earlier food allergic group effect concurrent breastfeeding alongside milk introduction food allergens development food allergy due small numbers possible explore differences food allergy phenotype therefore found evidence introducing solids food allergens whilst breastfeeding allergy preventative effect however results interpreted caution due sample size recommendations regarding infant feeding food allergy carefully considered although breastfeeding promoted many health reasons larger studies looking introduction food allergens development food allergy needed make final conclusion
remote sensing based retrieval concentrations water components relies largely accuracy atmospheric correction although variety atmospheric correction algorithms developed waters water leaving reflectance still underestimated extremely waters yangtze adjacent coast address issue paper proposes improved algorithm based spectral optimization algorithm coupled water atmosphere model model combines model constructed robotic network observation data simple semi empirical radiative transfer model water component retrieval four unknown parameters involved coupled model relative humidity fine mode fraction optical thickness near infrared nir wavelength tau lambda suspended particulate matter concentration parameters estimated global optimization approach based genetic algorithm without initial inputs validation results corrected remote sensing reflectance lambda ocean color data situ data show algorithm satisfactory accuracy root mean square error rmse absolute percentage difference respectively contrast lambda values retrieved using data processing system higher rmse respectively method implemented conveniently within open source code alternative operational tool atmospheric correction ocean color data including modis highly coastal regions yangtze bay coastal ocean eastern china elsevier inc rights reserved
introduction evaluate initial application recently published three step framework implementing trauma informed care pediatric health care network applying framework spread methods steps framework established commitment health care network leadership initial interest among clinical providers step set evidence based training goals created associated training content step step health care professionals health care teams participated single session hour training covered psychological impact injury illness related trauma identification traumatic stress symptoms respond children exposed potentially traumatic events concomitant quality improvement project allowed assess potential changes training participants favorable attitudes toward integration confidence delivering results compared participants demonstrated increases attitude toward cohens confidence delivering cohens discussion effective achieving proximal goals targeting attitudes confidence thereby demonstrating feasibility clinical relevance training implemented according three step framework future research examine methods training reach wide promote systematic change evaluate changes patient outcomes associated providers implementation
rapid development mobile internet people pay increasing attention wireless network security problem due specificity wireless network present rare see research wireless intrusion clustering method mobile internet paper proposes wireless intrusion alert clustering method based information mobile terminal method includes alert alert reduction alert classification introducing key information mobile terminal device method aggregates original hyper experimental results show appropriate real attack scenarios mobile internet reduce amount accuracy alert analysis
common skin condition staphylococcus aureus inflammation known anti inflammatory effects however studies discussed anti effects study found extract significantly reduced induced edema rat therefore evaluation platform using multiple pathogenic mechanisms established explore anti effects results showed inhibited bacterial growth lipase activity isolation system four isolated compounds greater anti bacterial activities anti testosterone induced proliferative effects others compounds displayed lipase inhibitory effects compound decreased cyclooxygenase expression downregulated prostaglandin production heat treated raw cells conclusion abundant display multiple anti capacities including anti bacterial anti lipase anti keratinocyte proliferation anti inflammatory actions hence great potential application anti skin care products effective component employed quality control marker
systematic studies brain formation hindered restrictions animal models adult post mortem tissues recently advances stem cell biology enabled early stages human development vitro present work analyzed cerebral derived human pluripotent stem cells radiation ray fluorescence order measure biologically valuable incorporated distributed developing brain findings indicate elemental inclusion consistent human brain tissue involves occurrence different concentration gradients also suggests active regulation elemental transmembrane transport finally analysis pairs elements shows interesting elemental interaction patterns change days development suggesting short long term associations storage similar compartments relevance time dependent biological processes findings light trace elements important human brain development support studies aimed unravel consequences disrupted metal homeostasis neurodevelopmental diseases including manifested adulthood
article proposes novel advanced differential evolution method combines differential evolution modified back propagation algorithm new proposed approach applied train adaptive enhanced neural model inverse model industrial robot arm experimental results demonstrate proposed modeling procedure using new identification approach obtains better convergence precision traditional back propagation method differential evolution approach furthermore inverse model industrial robot arm using adaptive enhanced neural model performs outstanding results
achieving complete conduction block atrial fibrillation ablation remains challenging hypothesized aspect atrial shorten distance improve catheter contact stability enabling complete block study investigated efficacy ablation patients three hundred twenty consecutive patients mean age years male persistent undergoing ablation including ablation enrolled ablation performed conventional posterior site group site group left atrial diameter enlargement greater group group complete block initial session significantly higher group group repeat session recurrence rate persistent complete block significantly higher group group left ventricular diastolic dimension significant predictors failed block significantly associated successful block improve initial success rate long term persistence complete block ablation
seen commonly however unique anatomical physiological structure makes difficult diagnose treat detailed history careful physical examination crucial diagnosis classification international disease study group also guides clinicians differential diagnosis review reviewed light literature
plain bearing post ground new method building large concrete ground support developed university technology patent method international patent application feasibility new method demonstrated large field tests concrete strips length width thickness support obtained first placing air tight membrane geotextile last second air tight membrane ground concrete built next step membranes boundary casting top second membrane low air pressure applied clearance two membranes clearance created geotextile shortening due loss hydration heat early shrinkage post possible without causing friction forces self weight balanced applied air pressure
human phase enzymes isoforms pesticides listed database updated periodically initial version includes enzymes isoforms john wiley sons inc
aim physiological modeling control study model understand biological processes apply identification control strategies system big challenge combine individualized control therapies physiological model based robust control methods requires combination mathematical knowledge numeric symbolic computations control engineering system identification control theory computer engineering formal methods software development testing biomedical engineering physiological modeling paper discusses current challenges topic three concrete examples diabetes tumor control depth anesthesia
paper describes multi institution effort develop data science service platform platform integrates advanced data management small large datasets access high performance computing distributed computing advanced networking goal develop platform flexible extensible still supporting domain research avoiding walled problem preliminary lessons learned next steps also outlined
anterior cruciate ligament acl commonly injured ligament great impact athletes causing long absence play linked increased risks osteoarthritis today literature suggests knee completely reduce acl injury mechanism risks ankle hand shown promising results aspects thus purpose research study effectiveness knee ankle restraint reducing acl injury risks increasing knee flexion reducing knee angles eighteen healthy asian male subjects performed drop vertical jump platform motion analysis capture carried measure knee flexion knee angles results show effect knee ankle restraint insignificant increasing knee flexion reducing knee angles initial contact peak vertical ground reaction force ankle showed trends increasing knee flexion angles initial contact effect insignificant similarly ankle show significant effects knee flexion angles peak knee angles instances knee little effect knee flexion angles showed significant effects angle increase conclusion knee ankle restraint found effect reducing acl injury risks jump landing ankle use adversely increase acl injury risks shown weak effects reducing risks knee used study found suitable reducing angles authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering university
despite marked progress past several decades convective storm remains challenge systems based linear extrapolation radar without much consideration meteorological fields variational doppler radar analysis system advanced convective scale analysis system capable providing analysis wind temperature humidity doppler radar observations although potentially useful still open question use fields improve study present results first attempt developing support vector machine svm box based method machine learning framework using analysis data key design points follows study domain divided many position fixed small boxes problem transformed one question radar echo appear box box based temporal spatial features include time trends surrounding environmental information constructed box based constructed features used first train svm classifier trained classifier used make predictions compared complicated expensive expert systems design allows system small compact straightforward easy maintain expand low cost experimental results show although complicated tracking algorithm used predict storm movement trend storm growth reasonable skill
island endemic species much higher risk extinction single representative family endemic island facing danger extinction along acceleration urbanization investigate population genetics evaluate importance mitochondrial gene individuals populations sequenced analyzed first comprehensive population ecological study species results recovered low genetic diversity weak structure multiple lines evidence including test mismatch distribution analysis phylogenetic topologies bayesian plot supported population expansion just last maximum statistics genetic diversity gene flow potential habitats reconstruction suggested south central areas island meanwhile small population size low genetic variation peripheral populations also implied niche reduction increasing human activity severe environment destruction main reasons causing recent decline population increasing risk extinction therefore urgent efforts implemented ensure long term survival present research provided way prioritize assess management strategies species
structured automatic voltage control architecture enables wide area closed loop coordinated voltage regulation owing inherent complexity task relies reduced control models simplified models system suitable voltage control fact however single reduced control model static optimal network configurations operating conditions pursuit advanced online voltage control future smart transmission grid paper presents adaptive control model reduction adaptive proposed formulation based complex network representation transmission grid additionally formulation employs spectral clustering complemented perturbation theory deliver adaptive indicative results presented new england bus network provide adequate justification proposed approach implications adaptive scheme control algorithm design selection also discussed
big data jobs usually executed large scale distributed computing platforms automatically divide job multiple computation phases contains number independent tasks run parallel data process two consecutive phases becomes bottleneck job execution improve performance approach push proposed send intermediate results next phase immediately generated avoids local disk traditional pull approach tasks next phase start data processing without waiting tasks phase finish task duplication another approach accelerate task execution multiple task copies compete processing data block push meets task duplication big data jobs significantly accelerated leading large amount redundant data transmission two phases address challenge propose software define data approach designing controller module control data process task controller request admission permit sending intermediate results next stage tasks propose online grouping algorithm reduce overhead frequent communication controller performance proposed algorithm evaluated extensive simulations
new design absorber triple band band range proposed radar cross section reduction stealth technology proposed absorber advantage ease design three layered structure designed modified ring printed dielectric material metal ground proper tuning geometry parameters structure triple band absorber achieved adjusted match effective impedance absorber free space hence wave transmission minimized reflection absorption rate maximized bands resonant frequency bands ghz ghz ghz absorption rates respectively measured triple band ghz ghz ghz total miniaturized absorber unit cell size simulation results show proposed absorber triple band high absorption rate suited radar cross section reduction stealth technology
third common variant observed patients disease functional effect variant unknown purpose study investigate molecular effect variant samples patients carrying variant analysed total rna followed real time polymerase chain reaction pcr using specific primers spanning variant detection protein fibroblast samples analysed sds page followed immunoblotting using monoclonal antibody resultsthe variant causes splicing defect resulting reduction full length mrna fibroblasts patients presence alternatively mrnas exon reduced level full length protein observed compared controls carrying variant study describes functional effect molecular mechanism pathogenic variant variant functionally important leads splicing defects reduced level protein
immune cell communication takes place intercellular transfer cytokines contact dependent interaction surface receptors immunological synapses issue european journal immunology point new hybrid mechanism cell delivery help cells based contact dependent transfer transfer process specificity cell contact dependent antigen dependent expression also required cell surface capture presented cell studies needed confirm phenomenon vivo test role transferred aspects cell help study provides exceptional take point makes excellent use mouse genetics work possible rules cells able order help
background aims vascular plants important questions regarding function remain unanswered due problems invasive experimental procedures highly sensitive tissue certain brown algae also possess tubes transport embedded large volumes extracellular matrix isolates cells therefore hypothesized tubes tolerate invasive experimentation better analogues higher plants sought establish experimental system methods predominant localization cellulose extracellular matrix verified using specific fluorescent markers confocal laser scanning microscopy tubes intact specimens loaded fluorescent dyes either movement dyes monitored fluorescence microscopy key results application demonstrated source sink bulk flow tubes revealed complexity tube structure branches junctions lateral connections elements proved comparatively easy pulsed injection enabled determination flow velocity individual elements direct visualization pressure induced flow direction across plates conclusions reversal flow direction across plates downstream element demonstrates critical requirement theory satisfied evidence exists high tolerance elements experimental manipulation promising alternative vascular plants studying fluid mechanics tube networks
selecting appropriate mid model critical high efficiency model transition data migration relational databases nosql databases explore problem uniform mid model design used model transition data migration relational databases nosql databases suggested approach proposes complete process use data features query features generate mid model predefined strategy transfer mid model physical model destination database establishing mapping migrate data source databases destination databases
authors investigated associations young adults perceived purposes emerging adulthood attitudes toward participation sample never married individuals ages female white united states young peoples perceptions period life associated acceptance reasoning accepting likelihood results showed perception emerging adulthood time prepare future family roles negatively associated acceptance whereas perception emerging adulthood time take risks positively associated acceptance perception emerging adulthood time prepare future family roles associated increased likelihood perception emerging adulthood time possibilities associated decreased likelihood implications future research discussed
background pregnancy termination fetal abnormality profound psychological consequences involved evidence suggests womens experience care influences psychological adjustment greatly value healthcare caring women circumstances presents challenges health professionals relate understanding womens experience qualitative study examined health professionals perceptions womens coping assessed extent perceptions congruent womens accounts methods fifteen semi structured interviews carried health professionals three hospitals england data analysed using thematic analysis compared womens accounts coping processes identify similarities differences results health professionals perceptions womens coping processes congruent womens accounts identifying roles support acceptance problem solving avoidance another pregnancy meaning attribution key coping strategies health professionals regarded coping unique process womens coping also considered role information providers essential helping women cope findings also indicate health professionals lacked insight womens long term coping processes potential positive growth following consistent lack following reported women conclusions health professionals perceptions womens coping closely matched womens accounts suggesting high level understanding however lack insight womens long term coping processes important clinical implications research suggests coping long term process provision beneficial women together findings call research appropriate ways support women post view developing psychological intervention better support women future
popular use high resolution satellite images research efforts focused land use scene classification scene classification effective visual features significantly boost final performance typical texture descriptor census transform histogram emerged powerful tool due effective representation ability however prominent limitation small spatial support area necessarily capturing key texture characteristics propose extended made three greater neighborhood scale proposed advantages also encodes useful information local structures meanwhile capture interactions images developed obtain higher categorization accuracy rates experimental results demonstrate proposed method achieve competitive performance compared state art methods society photo optical instrumentation engineers spie
variants gene recently suggested novel cause parkinsons disease herein entire gene sequenced french canadian french sample series patients unaffected controls effect single variants combined effect variants calculated sequence kernel association tests done entire gene level different domains exons total common rare variants identified patients controls significant association found variant haplotype representation variants entire gene domain exon levels patients versus controls results support role mutations common cause french canadian french populations elsevier inc rights reserved
circadian rhythms sleep wake cycle along range physiological measures severely disrupted individuals major depressive disorder mdd moreover several central circadian genes implicated potential genetic factors underlying illness candidate gene studies genome wide association studies however investigations molecular underpinnings circadian disturbances human brain quite challenging recent publication colleagues used novel approach determine rhythmic patterns circadian gene expression several regions human brain patterns disrupted mdd findings demonstrate healthy subjects several brain regions outside nucleus master clock exhibit diurnal gene expression patterns disrupted brains mdd subjects findings provide foundation future studies gene specific drug targets biomarkers disease
single stage converter designed wind energy conversion system eliminates multistage operation link filter elements thus resolving size weight reliability issues simple switching strategy used control switches changes variable frequency output electrical generator constant frequency supply feed distributed electrical load grid addition modified random sinusoidal pulse width modulation technique developed designed converter make overall system efficient increasing generating power capacity reducing effects inter harmonics sub harmonics generated technique uses carrier reference waves variable switching frequency calculate firing angles switches converter three phase output voltage converter close sine wave reduced thd comparison performance proposed technique conventional demonstrated power generated turbine proposed approximately increased thd reduces voltage current respect conventional
paper investigate whether board independence impact likelihood company reports weaknesses internal controls using sample firm year observations spanning period establish several findings first document negative relation board independence disclosure internal control weaknesses also document negative relation stronger firms leadership combined positions firms dual leadership next show board independence associated fewer account specific company level weaknesses finally show board independence associated timely remediation internal control weaknesses implementation standard effect board independence disclosure
preliminary findings suggest attention deficit hyperactivity disorder adhd associated disordered eating behaviour whether sufficient evidence suggest association adhd specific types disordered eating behaviour unclear furthermore uncertain whether specific features associated adhd differentially associated disordered eating behaviour systematic review seventy five studies conducted evaluate potential association adhd symptomatology disordered eating behaviour provide estimate strength evidence association overall moderate strength evidence exists positive association adhd disordered eating specific types disordered eating behaviour particular behaviour consistent evidence impulsivity symptoms adhd positively associated bulimia nervosa limited evidence association hyperactivity symptoms restrictive eating males females research required assess potential direction relationship adhd disordered eating underlying mechanisms role specific adhd symptoms development maintenance disordered eating behaviour propose framework used guide design future studies authors published elsevier ltd
paper new frequency agile filter structure analog signal processing proposed using mos technique contrast conventional analog building blocks filter designed mos transistors parasitic mos transistor used instead classical capacitors operating frequency range improved power consumption decreased simulations performed cadence environment using tsmc parameters
zinc essential trace element required living organisms critical roles structural component proteins cofactor enzyme catalysis importance zinc human metabolism illustrated effects zinc deficiency include diminished immune response reduced healing neurological disorders furthermore nutritional zinc deficiency fatal newborn growing animals zinc deficiency commonly caused dietary factors several inherited defects zinc deficiency identified commonly described inherited condition found humans several cases reported disorder associated mutations gene member family whose members encode membrane bound putative zinc transporters mutations members family different genes account cases defects detected another inherited form zinc deficiency occurs lethal milk mouse mutation gene member family transmembrane proteins results impaired secretion zinc milk gland similar disorder lethal milk mouse occurs humans cases studied changes detected presence several minor phenotypic differences zinc deficiency humans mice suggests human condition caused defects genes yet identified taking account fact definitive tests zinc deficiency disorder plus recent identification multiple members likely mutations genes underlie additional inherited disorders zinc deficiency
total patients diagnosed structured clinical interview dsm disorders revised identity disorder patients diagnosed structured interview dsm personality borderline personality disorder bpd groups administered multidimensional inventory dissociation mid patients significantly higher mid scores bpd patients different distributions mid scores different mid subscale profiles ranges mid scores core mid symptoms exhibited ranges mid scores patients presence alters identity confusion memory problems bpd patients identity confusion memory problems similar considered mostly produced different underlying processes multiple regression analyses showed core mid symptoms patients different predictors core mid symptoms bpd patients alter identities seemed generate phenomena patients whereas highest scoring bpd patients mid seemed manifest alter driven experiences bpd experiences appeared due mechanisms bpd specific stress driven rapid shifts self state disruptions framework perceptual organization without accompanying bpd specific dissociation like affective neurocognitive functioning defensive distress simple severe
address discourse sexual traditionally limited whole questions find answers history based documents historical university essay traces parts history origin tries interpret meaning document first part paper summarizes main features historical context alliance debate demographic campaign sexuality reproduction family feminist claims american birth control movement second part history identity instructions
purpose purpose study examine relationships among self reported screening measures attention deficit hyperactivity disorder adhd psychiatric problems driving related outcomes representative sample adults older living province ontario canada methods study examined results centre mental health ontario monitor ongoing repeated cross sectional telephone survey ontario adults year period measures included adhd measures adult adhd self report scale previous adhd diagnosis adhd medication use psychiatric distress measures general health questionnaire use pain anxiety depression medication antisocial behavior measure antisocial personality disorder scale mini international neuropsychiatric interview substance use abuse measures alcohol cannabis cocaine alcohol use disorders identification test audit alcohol smoking substance involvement screening test assist driving related outcomes driving drinking driving cannabis use street collisions past year gender age vehicle results total ontario residents sampled reported valid drivers license overall screened positive adhd symptoms screening tool greater percentage screened positive younger reported previous adhd diagnosis medication use distress antisocial behavior anti anxiety antidepressant medication use substance use social problems compared screened negative however statistically significant differences screened positive negative adhd symptoms self reported driving previous hour within hour using cannabis hash street race collision involvement driver past year sequential regression conducted predict self reported collisions younger age higher weekly driven showed higher odds collision involvement odds ratio cannabis use ever approached statistical significance discussion study first population based study representative sample adults older living ontario canada results showed relationship adhd screen collision age sex driven controlled however analyses based self report psychiatric diagnoses limited sample adhd respondents thus results interpreted caution
sustainability science solution oriented discipline yet theory rich discussions orientation structures efforts sustainability science argue social system theory explains societies communicate problems solutions identify pathways towards implementation solutions valuable explaining general structure sustainability science focus two key concepts first notion resonance offers way account sustainability science attended responded environmental risks product resonance reveal solution oriented research strategic coordination capacities resources information second interests self organizing processes explain sustainability science simultaneously advance multiple innovations value logic supports self organizing activities recognition human natural systems complex coupled mutually influencing give form theoretical framework offer case evidence renewable energy policy formation texas although states wealth rooted fossil fuel heritage texas generates electricity wind state towards climate change policy yet states reception wind energy technology illustrates social environmental systems aligned generate solutions address diverse needs simultaneously case demonstrates climate change politicians separate discrete problem achieving sustainable solutions resonance offers researchers framework designing
successful memory retrieval recognizing old information also correctly new information lures order avoid false memories correctly lures difficult semantically related information presented study compared lures distinct previously studied information behavioral difference suggests cognitive neural basis correct differs respect relatedness lures studied items present study sought identify neural activity aids suppressing false memories examining network brain regions underlying correct rejection related unrelated lures results showed neural overlap right hippocampus anterior gyrus associated related unrelated correct indicating neural regions support correctly lures regardless semantic perceptual characteristics direct comparisons related unrelated correct showed unrelated correct associated greater activity bilateral middle inferior temporal cortices regions associated categorical processing semantic labels related correct showed greater activation visual lateral prefrontal cortices associated perceptual processing retrieval monitoring thus related unrelated correct show common neural correlates related correct driven greater perceptual processing whereas unrelated correct show greater reliance salient categorical cues support quick accurate memory decisions
control scheme proposed three phase inverter based microgrid high penetration photovoltaic generation resources output inverter programmed dynamics nonlinear oscillator virtual oscillators within controller implicitly coupled physical electrical network asymptotic synchronization oscillators guaranteed design result stable power system emerges communication inverters time domain switching level simulation results microgrid penetration demonstrate merits proposed technique particular show load voltage maintained prescribed bounds spite variations incident irradiance step changes load
paper explores cultural sources inspired decision make education young children dysfunctional families decision emerged radical version identification children population serve distinguishes versions paper explores role sense self identification poles play composition identifies cultural heart proposes tensions general non identification situated part apart polish society particular induced create universal religion children religious ethnic physical generate prejudice intolerance violence
air exposed single chamber microbial fuel cell using designed reactors tested simultaneous real dye textile wastewater generation results digital image processing revealed maximum coverage area cells atmospheric enable good growth immobilized operation cathode electrode outperformed open circuit voltage higher control furthermore maximum volumetric power density achieved system suitable treatment removal decrease cod colour heavy metals high removal efficiencies observed cod removal efficiencies considerably lower observed single chamber mfc simplifies double chamber system bio electrochemical performance relatively low treatment capacity system seems encouraging contrast previous studies proof concept experiment demonstrated operate air exposed conditions seems promising alternative cathode efficient cost effective approach improve performance single chamber elsevier ltd rights reserved
prior unexpected early termination womens health initiative trial continuous conjugated estrogens acetate mpa prevailing view hormone replacement therapy low risk intervention immediate value symptom relief recently menopausal women probably conferred long term protection major chronic diseases affect women menopause rather replicating prior studies designed test whether beneficial associations consistently seen women starting near menopause found women beyond menopause views benefits risks changed dramatically unexpected early termination mpa trial initial report use world wide driven fear breast cancer cardiovascular benefits contrasting findings trial alone reported years later suggesting prevention coronary heart disease women began age years reduction breast cancer overall largely ignored key lessons effects organ systems vary age time since last physiologic exposure hormones differences regimens years since first report learned much characteristics women likely benefit range regimens also increased women indications initiate within years menopause benefits short term long term bone health coronary risk reduction critically facts women clinicians consider making decision use use frequently wrong applied
recently identified new family redox enzymes directly regulate actin cytoskeletal elements necessary morphology motility trajectory cells genetic assays reveal necessary sufficient actin organization cellular effects vivo biochemical assays purified protein reveal utilizes redox activity directly actin results identify proteins novel actin factors uncover redox signaling mechanism directly regulates actin cytoskeleton results also set stage depth characterization enzyme however difficult obtain sufficient amounts highly pure protein conduct biochemical structural imaging catalytic high precision studies herein describe means expressing high levels soluble recombinant protein bacteria likewise designed new purification strategy enables rapid efficient purification quantities highly pure active protein new strategy generating large amounts highly pure active protein aid research objectives designed characterize biochemical enzymology structural biology effects actin dynamics elsevier inc rights reserved
purpose present study analyse association sport personal factors incidence injury frequency severity within individual sports swimming collective sports football study deemed necessary explore different types sports using samples genders field competition sample composed athletes non injured males non injured females non injured belonging different sports spain male athletes average age years standard deviation female athletes average years cross sectional design strategy selective collection data means survey designs used order evaluate injuries auto report registry elaborated results indicated greater number total injuries higher injury rate associated athletes younger age experienced athletes collective athletes gender found important factor discussed relations variables conclusions study indicated
structurally functionally diverse secondary metabolites using acyl coa precursors recent studies engineering structural characterization facilitated use target enzymes produce novel functionally optimized compounds serve potential drug leads review summarizes insights gained research type iii discovery synthase plants novel bacteria fungi date least families type iii characterized highlighting utility development natural product libraries therapeutic development
victims trauma often remember experience traumatic later compared immediately event took place finding memory amplification effect associated increased experiencing symptoms however effect found almost exclusively field based studies examined whether effect replicated laboratory two studies exposed participants negative photographs assessed memory photographs analogue ptsd symptoms two occasions study analogue symptoms follow positively associated remembering negative photos study focused memory amplifiers people whose memory photos amplified time consistent field research analogue experiencing symptoms associated memory amplification overall findings confirm analogue ptsd symptoms also associated amplified memory trauma analogue elsevier ltd rights reserved
emergence electric aircraft needs adapt electrical architecture level power generation storage paper deals optimal sizing battery systems match energetic performances aircraft requirements application global weight minimized acting variables cut frequency filter used energy management discharge ratio storage components temperature optimization results obtained simulated annealing method assessed whole temperature range finally relation cut frequency temperature determined adjust board energy management
nowadays university college students digital learning style learning culture quite different parents teachers digital immigrants many previous research studies shown games powerful effective tool many educational domains military training marketing management health care foreign language learning computer programming computer graphics job specific skills politics etc however specific research discussing use serious games improve projection learning higher education setting technical graphics essential fundamental basis designer education core technical graphics projection technical graphics communication skill critical significant asset students engineering production design industrial design interior design architecture etc therefore main objective research develop serious game called helping university students net generation games generation master projection novel fashion game composed nine sub units including projection concept projection knowledge plane type judge plane front view selection top view selection right side view selection three view match proper model selection effectiveness game towards learning examined surveys department mechanical engineering national university department industrial education national university education evaluation results indicated university students favor using game enhance projection learning effectiveness also promote visualization skill model multi views moreover participants perceive plane unit unit satisfying unit proper model selection unit unit helpful unit learning projection furthermore completeness game broaden scope survey including participants different departments different universities valuable feedback collected participants useful refine game
thyroid hormones crucial brain development maturation vertebrates especially pre perinatal development disruption signaling leads multitude neurological deficits many animal models provided insight role brain development specific data affect brains ability learn adapt depending environmental stimuli rather limited review focus number learning processes like spatial learning fear conditioning vocal learning behavior abnormal signaling development shapes subsequent performance clear multiple studies deprivation leads defects learning interestingly changes local expression activator type seem important role taking account regulated space specific manner thus increasing pressure investigate local regulators potential factors involved learning processes also important proper adult human functioning elucidating role developmental various animal models important field advancing fundamental applied knowledge human brain function elsevier inc rights reserved
plasma numerical library intended solving problems dense linear algebra multicore processors plasma relies efficient algorithms expressed serial fashion implements automatic parallelization tracking data dependencies resolving data hazards runtime recently type scheduling incorporated standard allows transition plasma solution offered standard solution offered article studies feasibility transition
organizational theory long emphasized importance contingent environmental influences organizational performance similarly research demonstrated importance local political culture informal management performance local health system establishing influence contribute increasing inequalities performance among decentralized local health systems longitudinal studied relationship elements rural northeast brazil four year interval second study found local health system performance much improved two main factors appear interacted bring leadership vision power implement one individual local health system significant number senior health staff origins influences combine initiatives local state federal levels
climate change high political agenda weather emerged important issue travel behavioural research urban planning various studies demonstrate profound effects weather travel behaviours limited attention paid subjective weather experiences psychological mechanisms partially underlie effects paper integrates theoretical insights outdoor thermal comfort weather perceptions emotional experiences context travel behaviour drawing unique panel travel diary data greater respondents netherlands paper aims investigate extent weather conditions affect transport mode choices outdoor thermal perceptions emotional travel experiences findings point observed dry warm hot weather conditions stimulate cycling transport modes via mechanisms thermal mechanical comfort lead emotions travel overall public transport users less emotional experiences users transport modes active mode users appear weather sensitive theoretical contributions empirical findings discussed context climate change climate sensitive urban planning elsevier ltd rights reserved
throughout history natural ventilation remained preferred choice majority residential buildings commercial buildings natural ventilation went single option somewhat lost art mechanical ventilation systems air conditioning became standard second half century recently result environmental concerns particular greenhouse gas emissions buildings interest natural ventilation commercial buildings seen unfortunately natural ventilation use buildings resulted loss existing design know consequently limited new developments period comfort indoor air quality performance standards continuously nevertheless past years seen significant advances understanding fluid mechanics natural ventilation architectural fluid mechanics developed new subject response new scientific advances attempt restore confidence applicability natural ventilation practice paper presents ten questions building natural ventilation span different scales problem urban context building questions commonly asked designer considering natural ventilation preferred means cooling non domestic building answers intended provide links latest knowledge identify areas require additional research assist designers making appropriate decisions elsevier ltd rights reserved
urban free dog populations developing world managed local veterinary practitioners government programs non governmental organizations varied effectiveness lethal removal still commonly practiced vaccination fertility control methods increasingly adopted identifying method provides cost effective management needed inform dog population managers seek limit conflicts like dog spread disease describe agent based model simulates population free dogs indian city apply various lethal fertility control methodologies identify effectively lowered dog population size spatially explicit model includes temporal demographic details street dog populations modeled data study city tested pairing control type lethal fertility search method target efforts see efficacy altering dog population size age structure sterilization coverage number dogs handled models run years assess long term effects intervention found fertility control method targets areas city highest percentage intact outperforms fertility control lethal removal programs reducing population size significantly higher proportion population lethal program methods skewed population demographics towards significantly younger dogs thus likely increasing frequency conflict humans work demonstrates benefits modeling differing management policies free dogs elsevier rights reserved
prototyping evaluation imperative phases present product design development process although digital modeling analysis methods widely employed various product development stages still building physical prototype makes present typical process expensive time consuming therefore necessary implement new technologies virtual prototyping enable industry rapid controlled decision making process virtual prototyping come long way recent years current environments enable sound ample interaction generated models also important evaluate representative developed virtual prototype compared real world counterpart sense presence reported users virtual prototype paper describes systematic procedure develop virtual prototype first car prototype designed saudi engineers semi virtual environment steps develop virtual prototype cad computer aided design models explained detail various issues involved different phases development virtual prototype also discussed comprehensively paper describes results subjective assessment developed virtual prototype saudi designed users feedback recorded using presence questionnaire based user based study revealed virtual prototype representative real saudi car offers flexible environment analyze design features compared physical prototype capabilities virtual environment validated application car prototype finally vital requirements directions future research also presented
clinically used antipsychotics display similar affinity receptors likewise act receptor antagonists provide therapeutic benefit positive symptoms marked consistent improvement neurocognitive social cognitive negative symptoms since blockade receptors enhances social cognition potentially improves negative symptoms promising approach improved treatment schizophrenia develop drugs preferentially act versus likewise recognize starting high affinity ligands identified compounds behave ligands significant selectivity elsevier ltd rights reserved
cerebrospinal fluid csf biomarkers reflect different aspects pathophysiology relapsing remitting multiple sclerosis understanding impact different disease modifying therapies csf biomarker profile increase implementation clinical practice appropriateness monitoring treatment efficacy study investigated influence first line interferon beta second line therapies seven csf biomarkers correlation clinical radiological outcomes included patients healthy controls concentrations motif chemokine motif chemokine ligand like protein glial acidic protein light protein determined elisa analyzed patients higher levels controls subgroup analysis revealed higher levels patients treated first line therapy compared second line therapy respectively levels correlated relapse status levels correlated formation new magnetic resonance imaging lesions furthermore found association inflammatory degenerative biomarkers results indicate csf levels correlate clinical radiological disease activity providing additional dimensions assessment treatment efficacy
new high accuracy current mode function generator circuit presented proposed computational structure designed implementing multitude circuit functions many applications designs realization original function generator based utilization new third order approximation function allows strongly reduce approximation error implemented functions circuit requires much smaller silicon area comparing similar reported circuits current mode operation independence output current function generator technological parameters temperature variations additionally increase overall circuit accuracy simulations confirm theoretical estimated results showing accuracy functional core equal new proposed function generator based third order approximation function permits obtain wide output dynamic range maximal error implementing exponential function proposed function generator designed low voltage operation supplied
background commonly prescribed therapy connective tissue disease associated interstitial lung disease ild combination therapy included recently shown increase risk death hospitalization patients idiopathic pulmonary fibrosis whether increases risk adverse outcomes patients fibrotic ild including associated usual interstitial pneumonia remains unknown methods retrospective cohort analysis performed determine combined incidence rate death transplant respiratory hospitalization associated exposure fibrotic ild cohort treated served comparator group incidence rates compared incidence rate ratio generated negative binomial regression longitudinal pulmonary function response assessed using mixed effects linear regression models results fifty four patients treated forty three medication discontinuation due non respiratory side effects occurred cohorts respectively combined incidence rate adverse outcomes respectively similar incidence rates observed among groups demonstrated pulmonary function stability time group demonstrating marginal improvement conclusions significant minority patients tolerate due non respiratory side effects tolerate similar incidence adverse outcomes observed treated therapies associated stability pulmonary function elsevier ltd rights reserved
use set three resistive sensors based multi walled carbon nanotubes doped multi walled carbon nanotubes doped multi walled carbon nanotubes study fungal infection inoculated aspergillus section apply analysis using conductance variation sensors exposed infected distinguish uninfected infected aspergillus section obtain graphical representation providing tool simple fast detection identification fungal infection
purpose study adults hiv infection living old age critical investigate positive constructs resilience determine factors associated psychological examine hiv related factors adverse conditions psychosocial characteristics associated resilience ability back sense self efficacy design methods analyzed data longitudinal study aging national health aging sexuality gender study focusing subsample gay bisexual older men multivariate linear regression used identify factors contributed resilience sample recruited sites across united states results resilience independently associated psychological health related quality life multivariate analysis adjusting demographic characteristics previous diagnosis depression negatively associated resilience time since hiv diagnosis positively associated whereas victimization negatively associated social support community engagement positively associated resilience implications individual structural environmental characteristics contributed resilience findings used develop interventions incorporating increased understanding factors associated resilience
work shows post traumatic stress disorder ptsd predicts increased risk preterm birth causal pathway uncertain evaluate associations ptsd complications explore pathophysiology impacts pregnancy methodsthis retrospective cohort analysis veterans health administration covered used data clinical administration mothers current ptsd identified using icd diagnostic codes code present year historical ptsd medical administrative data used identify relevant obstetric diagnoses demographics health military deployment history used poisson regression robust error variance derive adjusted relative risk estimates association ptsd five clinically relevant complications gestational diabetes gestational hypertension growth restriction secondary outcomes included obstetric complexity repeat prolonged delivery delivery mothers ptsd diagnoses current ptsd mothers complication births adjustment current ptsd diagnosis reference ptsd associated increased risk confidence interval ptsd also predicted prolonged day delivery repeat delivery conclusionsthe observed association ptsd consistent understanding ptsd neuroendocrine cardiovascular health
background research found injury rates football higher competition practice however little research association injury rates type football practices specific rates compare purpose study utilized data national athletic association injury surveillance system describe mens football practice injuries academic years event types regular practices study design descriptive epidemiological study methods football data academic years analyzed annually average mens football programs provided data universities football injury rates per athlete exposures aes injury rate ratios cis injury proportions reported results captured football injuries injuries reported regular practices followed aes reported regular practices followed highest injury rate found aes followed aes regular practices aes aes rates significantly different one another distributions injury location diagnoses similar across event types injuries occurring lower extremity consisting sprains strains however injury mechanisms varied proportion injuries due player contact greatest followed regular practices contrast proportion injuries due overuse greatest followed regular practices conclusion injury rates highest varied type practice event higher practice injury rates reported addition greater proportions injuries reported regular practices greater proportions exposures reported regular practices efforts minimize injury types practice events essential mitigating injury incidence related contact
background aims treatments crohns disease linked serious infections malignancies complications pooled analyzed clinical trials humanized fragment tumor necrosis factor quantify safety events patients methods collected data placebo controlled trials open label studies dose regimen study conducted globally april total patients moderate severe treated patient years exposure data analyzed groups patients placebo controlled trials treated placebo weeks group patients exposed durations weeks studies group incidence rates incidence patient years adverse events aes calculated first dose days approximately half lives last dose results group serious aes similar among patients given patient years placebo patient years serious infections malignancies low among patients receiving short term treatment patient years patient years respectively group increase long term treatment patient years patient years respectively studies group psoriasis dermatitis low group patient years patient years respectively placebo group per patient years per patient years respectively psoriasis dermatitis increase long term treatment patient years patient years respectively studies group conclusions based analysis data pooled trials patients safety profile long term therapy therapy similar reported short term studies overall rates aes serious infections malignancies psoriasis increase long term treatment suggesting favorable risk benefit ratio long term therapy
objective antiretroviral therapy art longevity patients infected human immune deficiency virus hiv since little known health related quality life hrqol persons art least five years present study investigated hrqol patients method medical records structured interviews world health organization quality life hiv instrument employed obtain information respondents results univariate multivariate regression analyses showed respondents highest scores physical domain mean lowest scores environment domain mean thus physical domain greatest impact patients overall hrqol self education hiv related issues significantly correlated domains hrqol scores physical psychological independence social relationships environment significance results hrqol assessments identify address patients needs important guidelines developed yield improved care art patients
since advent nano materials unique mechanical properties chemical properties concern many experts scholars describes application research results recent years nano materials construction industry adding nano materials ordinary concrete improve performance concrete including strength toughness durability properties recent years increase number nano materials researchers nano materials use construction industry also better understanding yet fully grasp mechanism action need depth research exploration
preclinical alzheimers disease relatively recent concept describing entity characterized presence pathophysiological biomarker signature characteristic absence specific clinical symptoms rising interest scientific community define early target population mainly failures recent clinical trials despite evidence biological effects brain compounds conceptual framework recently proposed preclinical phase however data exist silent stage performed systematic review investigate concept defined across studies review highlights substantial heterogeneity concerning three main determinants preclinical normal cognition cognitive decline pathophysiological signature emphasize need preclinical concept standardized population based case control studies using unified criteria alzheimers association published elsevier inc rights reserved
introduction past years seen dramatic advances understanding molecular pathogenesis bcr negative myeloproliferative neoplasms mpns knowledge come novel molecularly targeted therapies jak inhibitors decrease symptoms improve quality life patients mpns despite advances progression disease acute blast phase remains difficult predict even difficult treat high rates disease relapse mortality areas covered performed literature review known risk factors progression mpns towards blast phase treatment options transformed disease including approved agents herein review current literature suggest strategies improving outcomes future expert commentary understanding biologic basis transformation mpns chronic blast phase needed order predict prevent treat cases patients mpns blast phase encouraged participate clinical trials whenever possible
background acid lipid mediator multiple biological activities affect progression various cancers malignant contains high levels vascular endothelial growth factor vegf although receptors widely expressed normal cancer cells little known effect host cells therefore evaluated effect specifically peritoneal cells assessed another aspect tumor biology mediated host cells materials methods effect production vegf evaluated elisa northern blotting next quantified human mouse vegf separately fluid mice inoculated human gastric cancer thus evaluated ratio host derived vegf malignant results addition enhanced vegf production gene activation effect strongly inhibited pre treatment indicating effect mainly dependent signal vegf fluid weeks tumor inoculation derived mouse cells weeks however ratio host derived vegf reduced suggesting ratio host derived vegf higher earlier phase conclusion tumor growth often associated increase concentration stimulation vegf production important role growth cancer cells disseminated peritoneal cavity elsevier inc rights reserved
current study examined relationship early language ability autistic like traits adulthood utilising data participants longitudinal study general population language performance years measured language development survey years participants completed autism spectrum quotient vocabulary size years negatively associated total score scores communication social skills subscales adults late also likely high scores communication subscale first study show association early language ability autistic like traits adulthood
methodology optimum sizing different components rotor diameter electrical generator rating battery capacity standalone wind battery system proposed paper basis time series simulation system performance along different design constraints entire set feasible design options also known design space identified rotor diameter rated power diagram design space standalone wind battery system identifies entire envelope within feasible system designed optimum configuration standalone system identified basis minimum cost energy kwh observed cost energy sensitive magnitude average demand wind regime sensitivity capital cost minimum cost energy also studied elsevier ltd rights reserved
years motor interference paradigms used investigate influence action observation action execution research called automatic focused variables play modulating role investigated potential confounding factors interestingly furthermore number functional magnetic resonance imaging fmri studies tried light functional mechanisms neural correlates involved inhibition however fmri studies presumably due poor temporal resolution primarily focused high level processes neglected potential role low level motor perceptual processes current eeg study therefore aimed influence low level perceptual mechanisms high level cognitive mechanisms focused potential differences visual component related processing biological motion readiness potential component related motor preparation high level component interestingly detected effects components suggesting interference effect automatic paradigm related high level processes self distinction also low level influences perception action action perception moreover documented relationships neural effects autistic behavior
monitoring system developed grasp malicious activities internet early stage cope monitoring system consists network sensors deployed widely internet sensors capture incoming packets goal system analyzes captured malicious packets provides effective information protecting good internet users malicious activities provide effective reliable information sensors deployed secret hidden outside hand attackers detect sensors attempt known localization attacks monitoring systems actual location sensors revealed attackers almost impossible grasp latest tactics used attackers thus previous work proposed packet sampling method samples incoming packets based attribute packets increase tolerance localization attack keep high quality information system result almost counter localization attack generates graph detect sensor however cases proposed sampling method works attackers advantage appear clearly graph therefore propose advanced sampling methods sample incoming packets based multiple attributes packets paper present improved methods show promising evaluation result obtained simulation
control algorithms software implementation play crucial role real time embedded systems reliability safety field programmable gate arrays fpga based hardware loop relatively new technique used development testing hard real time complex systems system simulator implemented fpga provides real time reactions control system aim work present simulator cage induction motor drive control algorithm development testing real time conditions testing platform consists target microcontroller unit implemented software drive control connected real time fpga simulator drive
search based structured prediction methods shown promising successes computer vision natural language processing recently however existing approaches lead complex multi stage learning process suited scene labeling problems output space paper stacked learning search method proposed address scene labeling tasks design simplified search process consisting sequence ranking functions learned based stacked learning strategy prevent fitting method able encode rich prior knowledge incorporating variety local global scene features addition estimate labeling confidence map improve search efficiency two aspects first search space effectively pruning low quality solutions based confidence scores second employ confidence map additional ranking feature improve prediction performance thus reduce search steps approach evaluated semantic segmentation geometric labeling tasks including background flow geometric context rgb data set competitive results demonstrate stacked learning search method provides effective alternative paradigm scene labeling
proposed conceptual model stereotype violation stereotype activation combine create narrow band acceptable career strategies women management utilizing sample chinese managers pairs women men matched education years work experience employing organization examined effects gender three career development outcomes number supervised life satisfaction career satisfaction results indicated female significant negative main effect three outcomes ten significant interactions supported theoretical effects stereotype violation activation womens managerial career development consistent conceptual model findings suggest chinese women management face narrow band acceptable career strategies especially area creating social capital results highlight importance testing stereotype violation stereotype activation effects creating social capital appropriate networking
objective analyse clinical serological differences rheumatoid arthritis psoriatic arthritis psa patients anti tnf therapy clinical remission methods angiogenic proinflammatory cytokine serum levels determined multiplex elisa patients psa clinical remission healthy controls ultrasound scans made hands results psa patients remission active patients healthy controls included psa patients significantly lower disease activity according esr according crp lower serum levels proinflammatory angiogenic cytokines patients remission psa patients cytokine levels similar healthy controls patients remission similar levels active patients globally patients remission signal plus psa meeting criteria ultrasound defined active patients significantly higher levels psa patients doses anti tnf frequently monotherapy compared patients respectively conclusion psa patients remission lower levels local systemic inflammation patients remission even though significantly higher percentage psa patients doses anti tnf mainly monotherapy
sleep disruptions represent core feature bipolar disorders widely studied use actigraphy objective measure motor activity sleep finding objective outcomes reliably measure sleep bipolar disorders essential developing better therapies improving follow monitoring strategies aim understand role actigraphy objective measure sleep bipolar disorder undertook systematic review meta analysis studies using actigraphy detect changes activity sleep patterns bipolar patients versus healthy controls primary outcome measures analyses activity mean sleep duration secondary outcomes analysed sleep onset latency sleep efficiency time sleep onset thirteen studies comprising subjects met quality criteria inclusion results show decrease activity mean altered pattern sleep bipolar patients analyses suggest results generalized bipolar condition underlies manic depressed episodes phases study highlights role actigraphy important objective tool ambulatory monitoring sleep activity bipolar disorders elsevier ltd rights reserved
source many valuable tools molecular biology genetic manipulation dna cloning vectors based serine site specific dna recombination systems derived efficiency simplicity serine also used diverse synthetic biology applications present genome new phi investigate conditions integration excision phi genome phi belongs largest cluster like encodes serine site used efficiently integrating plasmid constructed using phi int locus site phi occupied several genomes including mobile element varies gene content size host species serine require encoded recombination factor activate excision reaction phi identified function confirmed vivo active vitro recombination assays phi site specific recombination system likely important addition synthetic biology genome engineering toolbox importance spp producers secondary metabolites including many clinically useful antibiotics derived important tools genetic engineering enable integration dna chromosome ease high efficiency recently researchers applying variety applications synthetic biology including rapid assembly novel combinations genes biosensors important requirement optimal experimental design using however need multiple enzymes different specificities integration sites order provide broad platform identified validated newly isolated phi phi active vitro vivo specific recognition site integration present wide range different including emerging model bacterium research
water pollution generated industrial effluents discharge threat maintenance aquatic ecosystems human development river located northeast brazil receives industrial pretreated effluent load city brazil present study aimed assess water quality water reservoir physicochemical characterization quantification metal concentration iii assessment carried using study performed throughout period comprising september physicochemical variables chloride total solids electrical conductivity presented values waste discharge point significantly different located waste releasing point apart metal concentration showed variable behavior throughout monitored period levels considered guidelines natural anthropogenic sources seem involved resulting environmental scenario reduction rate along increase rate species observed presence toxic substances water reservoir moreover correlation analysis stated association aforementioned toxicological effects delivery industrial waste products assessment performed highlighted presence toxic substance water river especially consequence industrial activity fact threaten therefore human health population studied region elsevier rights reserved
order make dynamic voltage concurrently compensate low order harmonics voltage eliminate influence digital control system performance propose novel double closed loop digital control strategy consisting fundamental proportional resonant control voltage loop selective harmonic control inductance current loop mainly analyse discretization effects virtual method step response method present straightforward digital design method next method design parameters fundamental selective harmonic controllers discrete domain inhibit influence sampling calculation delay etc steady state error dynamic response performance finally prototype developed tested experimental results indicate proposed control strategy satisfies requirement voltage quality sensitive loads achieves good dynamic response performance
assessment investment efficiency plays critical role investment prioritization context electrical network expansion planning hence paper proposes new criteria cost efficiency investment applied investment ranking process electrical network planning based assessment new investment candidates impact active power losses bus voltages line loadings network three general criteria chosen due strong economic influence active power losses line loadings considered due significant impact quality supply allowed voltage profile electrical network reliability supply addressed since criterion already extensively applied solutions regarding investment efficiency assessment proposed ranking procedure involves stochastic approach applying monte carlo method scenario preparation number scenarios reduced means procedure order speed investment efficiency assessment proposed ranking procedure tested using standard new england test system results show based newly involved investment assessment criteria indices system operators obtain prioritized list investments prevent excessive economically spending elsevier ltd rights reserved
human gene malignant brain tumors considered play role tumorigenesis pathogen defense encodes protein multiple receptor cysteine rich domains involved recognition binding broad spectrum bacterial pathogens domains encoded highly homologous repetitive exons whose number humans vary due genetic polymorphism characterized porcine gene mrna genomic level assembled porcine cdna sequence pcr amplified vesicle rna porcine cdna contains open reading frame transcript gives rise putative polypeptide amino acids calculated mass kda compared human contains four terminal domains northern blotting revealed transcripts similar size tissues analyzed analysis suggested existence secreted transmembrane variants porcine gene spans chromosome contrast characterized cdna genomic clone contained exons coding terminal domains different mammalian large differences number exons utilization transmembrane exon exist data suggest porcine gene share human gene additional variations number coding exons elsevier rights reserved
objectives type diabetes chronic condition affects nearly three million including immigrants timing first onset diabetes linked several severe diseases yet dearth empirical studies examine timing first onset diabetes among general among immigrants ethnic minority populations within canada applying event history techniques canadian community health survey address research void examining factors contribute first onset diabetes among immigrant visible minority populations canada given gendered patterns epidemiology diseases differences risk factors men women gender specific models results showed south asian black women developed diabetes earlier compared women similarly south asian chinese black south east asian men developed diabetes earlier men significant important finding analysis risks developing diabetes completely black women accounting lifestyle factors south asian women however significant attenuation risks accounting lifestyle factors findings strikingly different immigrant men specifically risks developing diabetes increased accounting lifestyle results suggest development gender specific lifestyle interventions targeted specific immigrant groups increased risks developing diabetes earlier life course
background department veterans largest provider hepatitis treatment although antiviral regimens becoming simpler hepatitis typically prescribed primary care providers veterans extension community health outcomes echo program launched promote primary care based hepatitis treatment using based specialist support aimed assess whether primary care provider participation echo associated hepatitis treatment sustained response methods identified primary care providers sites responsible patients chronic hepatitis infection total patients primary care provider participating echo patients primary care provider exposure modeled patient level time varying patients became exposed primary care provider participation echo session multivariable cox proportional hazards modeling assessed association echo exposure hepatitis treatment among treated patients modified poisson regression assessed relationship exposure sustained response results adjustment exposed patients received significantly higher rates antiviral treatment compared patients adjusted hazard ratio confidence interval rate primary care provider initiated antiviral medication among treated patients reviewed echo compared among patients difference adjusted rates sustained response observed patients exposed primary care providers similar crude rates primary care providers versus specialists conclusions national implementation echo positively associated hepatitis treatment initiation primary care providers without differences sustained response published elsevier inc
mrna differential display technique used identify genes seedlings whose expression modified systemically infection experiments different oligonucleotide primer combinations revealed single gene instead quantitative accumulation multiple transcripts found transcripts levels nitrate reductase nitrate reductase high percentage identity showed consistent increase hours inoculation reverse northern blotting revealed existence basal levels transcripts different adult tissues however systemic levels rose dramatically seedlings acid methyl defence also modified enzymatic activity nitrite nad similar kinetics application induced activated differentially possible activity related specific host defence response elsevier masson sas rights reserved
rainwater harvesting provide alternative water source demand little treatment depending end use used water treatment filtration aid applied primary show direct filtration hydraulic rapid mixing using cationic corn starch primary considerably improves roof harvested rainwater quality achieving removal efficiencies apparent colour turbidity log unit total log unit escherichia coli meeting guidelines turbidity even potable purposes cationic corn starch proved suitable primary filtration performed single layer sand filter coefficient uniformity effective particle size hydraulic loading rate day however unit required meet absence faecal
medical imaging become integral part modern medical technology increasingly image information provided imaging technology complement computed tomography magnetic resonance imaging mri images combine unique information diagnose brain diseases radiation therapy medical imaging process easy produce noise impact doctors diagnosis medical image important significance addition image edge extraction helpful clinical diagnosis paper constructs pulse coupled neural network medical image processing exponentially time used adjust threshold pulse coupled neural network online integrating makes network biological function introduction nanoscale also significantly reduce scale promote development neural network hardware implementation numerical simulation verifies superiority using network medical image fusion image image edge extraction
paper presents design sampled analog wavelet processor architecture implant application using discrete wavelet transform basic element sampled analog wavelet processor architecture operational amplifier based switched capacitor integrator circuit architecture input signal frequencies different predefined frequency band based sensitivity region different frequencies using arbitrary tree structure presented architecture beneficial terms processing time input signal area complexity avoiding quantization encoding process part data converter circuits simulation results architecture carried cmos technology
objective commonly observed patients solid tumors study aimed evaluate prognostic role circulating pretreatment platelet count large series patients head neck squamous cell carcinoma methods retrospectively studied patients treated single institution disease specific survival local regional distant recurrence free survival analyzed according distribution platelet count results defining platelet count cut point best predictive capacity classified patients two groups high platelet count low platelet count univariate analysis significant differences disease specific survival depending pretreatment platelet count year specific survival rates patients low high platelet count respectively according results multivariate analysis patients high count platelets tendency lower disease specific survival hazard ratio reach statistically significant differences conclusion platelet count significantly associated survival univariate analysis however multivariate analysis lost prognostic capacity limiting utility prognostic marker patients considering separately primary tumor location patients cancer high platelet count significant decrease disease specific survival elsevier ireland ltd rights reserved
hereditary angioedema hae rare bradykinin mediated disease characterized recurrent attacks subcutaneous edema life threatening hae affects ethnic groups equally differentiate age sex race however availability therapies varies amongst countries resulting lack uniformity care disparity medication availability since hae rare disease frequently overlooked diagnosis missed even diagnosis treatment management often less optimal reasons essential practice parameters guidelines chapter focus recent guidelines guidelines deal recognition diagnosis medical care patient management assessment essential provide optimal care people rare disease intent guidelines thus chapter reduce morbidity mortality restore normal quality life patient hae review guidelines various regions world international group recommendations addition specific patient populations pregnant elderly juvenile require modified treatment regimens reason included data intent chapter aid practitioner holistic care patient hae order ultimately provide best standard care possible
defects associated syndrome influence diverse intracellular metabolic pathways including mitochondrial functioning report month old female infant month old female infant typical clinical radiological laboratory features syndrome light microscopic evidence mitochondrial pathology muscle biopsies homozygous pathogenic mutations gene gene respectively additionally mitochondrial respiratory chain enzymology analysis first girl showed low activity complexes iii also review five children previously reported literature diagnosis additional mitochondrial findings muscle biopsies conclusion first study patients molecularly confirmed disorder features concomitant mitochondrial underscores role secondary mitochondrial dysfunction syndrome potentially contributing clinical phenotype
background since conception mid international participation extreme sports grown rapidly recent death extreme winter games demonstrated serious risks associated sports purpose examine incidence prevalence head neck injuries extreme sports study design descriptive epidemiological study methods national electronic injury surveillance system used acquire data sports included winter summer games data database collected individual sport per year type cumulative data overall incidence injuries entire year period calculated national estimates determined using weighted calculations incidence rates calculated extreme sports using data outdoor foundation participation reports results million injuries reported head injuries neck injuries sports highest total incidence severe cervical skull fracture accounted extreme sports highest percentage severe conclusion number serious injuries suffered extreme sports increased participation sports continues grow greater awareness associated sports offers opportunity sports medicine orthopaedic physicians advocate safer equipment improved site medical care research regarding extreme sports injuries
acute injuries sport still problem limited knowledge incidence severity different sports national level exists sweden sports mandatory injury insurance athletes insurance company injury data systematically kept national database aim study identify high risk sports respect incidence acute severe injuries sports reported database number incidences injuries injuries leading permanent medical impairment calculated year approximately injuries licensed athletes eligible analysis eighty five percent injuries reported football ice highest injury incidence ice females higher risk compared males sport football high risk sports numerous injuries high incidence injuries ice football sports thus sports target preventive actions national level
paper presents statistical method analysis wind farm surge transients employs wind farm high frequency transients model developed within software package method features monte carlo simulation applied numerical analysis wind farm transients produces statistical distribution within wind farm electrical network used statistical semi statistical methods wind farm equipment insulation coordination assist wind farm risk management surge protection optimisation wind farm incidence computed aid detection network data time accounting actual wind turbine geometry exposure terrain topography wind turbine effective height exposed locations determined physical governing initiation subsequently obtained wind farm equipment statistically described means kernel density estimation procedure application proposed method actual wind farm provided paper elsevier ltd rights reserved
advanced chemical remediation strategies advanced oxidation processes turned feasible solution treatment bio refractory effluents case olive wastewater review paper focus relevant state art advanced physico chemical processes including wet oxidation reagent coagulation electrochemical solar driven hybrid processes treatment presented particular extent organic pollutants efficiency grade mineralization achieved various treatments available today addressed special attention given different configurations treatment line sequences important effect parameters novel materials implementation real industrial scale latter includes latest advances applications treatment coagulation ferromagnetic ease recovery multiple long term use low cost catalysts doped enhanced sunlight activation based catalysts mixed doped electrodes among others solutions reported management secondary sludge produced treatment processes also discussed moreover specific energy consumption associated costs comparison different processes proposed also given elsevier rights reserved
targeting essential viral rna dependent rna polymerase nucleotide analogues play major role antiviral therapies family hepatitis virus hcv chronically infected patients using combination drugs generally include modified analogue delivered nucleotide viruses emerging whose closely related hcv yet drug clinically approved acute infections purified virus full length viral used assemble stable binary complex made virus specific rna primer templates complex used assess selectivity towards nucleotide analogues bearing modifications position show virus exhibit discrimination pattern analogues unlike hcv presence beneficial rendering discrimination pattern analogues act non rna chain nucleotide selectivity towards modified potency corresponding analogues infected cell cultures
face face communication communication online environments convey information beyond actual verbal message traditional face face conversation ancillary meaning emotion aspects speech actual verbal gives contextual information allows appropriately understand message paper textual define written manifestations nonverbal visual elements supplement replace written language expressed words symbols images combination elements develop typology textual using data facebook present conceptual framework antecedents consequences use textual implications theory practice discussed published elsevier inc behalf society consumer psychology
slope supported geotextile bag high supporting strength local materials convenient construction adaptability environmental protection low noise low engineering cost advantages rapid development wide application achieve supporting retaining structure red beds slope effectively play role protection convenient construction reduce project cost conditions indoor model comparative analysis natural slope model without model supported geotextile carried obtain conclusion protective effect better specific suggestions suitability construction supporting structure put forward
provide important ecological services biodiversity climate regulation cultural benefits tourism however many worlds declining suffering significant decline living past half century situation emphasizes need assess monitor conditions using variety methods study new method assessing conditions inform management using participatory mapping experts islands described occupational recruited map conditions uses threats stressors using internet based mapping website data reveal uneven geographic distribution conditions frequently mapped perceived healthy characteristics large amount physical structure markers threatened species present large amount live cover greatest perceived threats invasive species water pollution areas important characteristics perceived threats perceived recovery potential plotted identify areas requiring critical management attention authors found perceptions healthy conditions perceptions threats nine ten familiar frequent activity type within tourism familiar perceived high recovery potential given novelty participatory mapping methods assess strengths weaknesses method evaluated authors propose management typology areas inform future management absence primary data supplement underwater surveys remotely sensed data condition participatory mapping provide cost effective means assessing conditions identifying place specific locations requiring management attention
paper several optimizations proposed enhance quality detection algorithms automotive applications considering directions proposed limited transform newly introduces image splitting angle limiting schemes number possible angles line voting process addition unnecessary edges along horizontal vertical directions pre defined removed edge detection procedures increasing detecting accuracy remarkably simulation results shows proposed recognition algorithm achieves accuracy computing speed frame sec superior results previous algorithms
insulin pump users worldwide depend insulin infusion sets predictable delivery insulin subcutaneous tissue yet emerging data indicates associated many pump related adverse events contribute potentially life threatening problem unexplained hyperglycemia relative scarcity published research date heterogeneity regional practices increasing demand international standards guiding use prompted panel diabetes nurse educators last february italy discuss framework optimizing practice europe panel first identifying often overlooked issues affect patients experience pump therapy partial complete skin pathologies unpredictable variations insulin absorption demands site rotation set changes second establishing direction developing cohesive protocols assure long term success reported article panel examined related complications pump therapy encountered clinical practice considered country wide policies prevent mitigate complications updated priorities improving education issues device selection skin care unexplained hyperglycemia recommendations relevant possibility closed loop systems available near future
aim present study aimed evaluate impact activity key enzymes situ methods formation performed bovine exposure min accomplished active inactive individuals enzyme activities peroxidase alpha situ resting saliva participants analyzed directly oral exposure addition simultaneous visualization enzymes extracellular bacteria carried fluorescent patterns analyzed fluorescence labeling staining addition distribution examined gold transmission electron microscopy selected samples results enzyme activities per oxidase detected active conformation neither exposure time activity impact enzyme activities gold indicated active subjects tends molecules inactive active individuals revealed similar ultra structural pattern conclusion enzyme activities high similarity active inactive subjects thereby oral exposure time significant influence reflects high uniformity initial phase min concerning enzymatic functions however tendency towards active individuals karger basel
paper voltage voltage total harmonic distortion thd distribution network studied proposed electrical network modeled electrical source line source assumed electrical load network sample electronic load load rectifier bridge output terminal connected capacitor bank linear resistance distribution network power quality analyzed changing load impedance capacitor bank number load network voltage thd distribution network studied using software
purpose study develop scale language measuring different dimensions belief scale subjected exploratory confirmatory factor analysis sample individuals men women recruited different cities pakistan exploratory confirmatory factor analysis items retained three defined factor structures belief positive negative extinction alpha coefficients subscales ranged convergent discriminant validity subscales belief scale determined finding relationship belief scale belief scale anxiety subscale belief world scale results support newly developed scale promising validity
exploratory research examines whether attracted professional level built environment industry physical risk hence potentially thereby likely contribute physically risky workplace climates using individual level data occupational attractiveness built environment industry construction management architecture found positively significantly predicted physical risk taking propensity comparator risk taking propensity gambling conversely occupational attractiveness comparator profession financial services found significantly predicted gambling risk taking propensity physical risk taking propensity although exploratory finding two key built environment industry found attractive physical risk suggests constituent within industry industry whole perhaps self reinforcing suboptimal workplace safety climate accordingly constituent industry need separately collectively consider phenomenon physical risk taking propensity amongst professionals order effectively set manage site work place safety climate professionals ultimately responsible creating delivering sector physical risks site workers
big data analytics recognized one major issues current information society raises several challenges opportunities many fields including economy commerce public health administration national security scientific research use visualization techniques make sense large volumes information essential ingredient especially analysis complex interrelated data represented graphs growing availability powerful inexpensive cloud computing services naturally motivates study distributed graph visualization algorithms able scale size large graphs study problem designing distributed visualization algorithm simple implement whose computing infrastructure require major hardware software investments design implement experiment force directed algorithm popular open source framework distributed computing based vertex centric design paradigm algorithm tested real artificial graphs one million edges experiments show scalability effectiveness technique compared centralized implementation force directed model graphs one million edges drawn minutes spending per drawing cloud computing infrastructure amazon published elsevier inc
introduction substances persistent industrial chemicals resulted global environmental exposures previous epidemiological studies reported possible effects immune system developmental exposure possible impact childhood infectious disease unclear objectives investigate association prenatal exposure symptoms infections age years methods child cohort going prospective study childrens health serum concentrations acid acid acid acid acid measured pregnant women gestational week women reported symptoms infection child every two weeks one year period association prenatal exposure symptoms estimated using logistic regression model negative binomial regression model latter outcome reported incidence rate ratio models adjusted maternal age educational level parity child age results average children experienced symptoms infection time one year exposure high compared low associated statistically significant increased proportion days fever trend increased odds experiencing days fever median latter tendency also apparent higher concentrations tended increase number episodes occurrence fever fever nasal discharge one year study period conclusion found positive association prenatal exposure prevalence fever sensitive marker infection finding agreement effect prenatal exposure wider implications childhood infectious disease deserve attention elsevier ltd rights reserved
laboratory experiments conducted large scale compound channel investigate flow patterns cross sections equation derived momentum equation flow continuity equation equation two shear stress terms ignored due negligible contributions simple expressions obtained several groups experimental data published literature used verify model comparison experimental predictive results indicates proposed method capable accurately forecasting stage discharge compound channels finally simple analytical solution model velocity parameter discussed
pedagogical agents stimulate cognitive socio aspects instructional activity virtual learning environment context visual design pedagogical agent simulating human either realistic rendered naturalistic rendered though design factors agent stereotypes roles gender studied extensively issue pedagogical agents receive sufficient attention research community decision regarding agents visual faced instructional designers implementing pedagogical agent virtual learning environment hence objective study investigate relationship among agents visual learners cognition learners socio behaviours virtual learning environment one hundred forty four university asian university interacted either realistic agent rendered naturalistic agent rendered virtual learning system delivers basic computer programming results showed agent imposed cognitive load hindered learning transfer particularly male learners mediation analysis demonstrated effects agents design realistic versus learning transfer among males fully mediated learners load hypothesis agent elicit higher socio responses learners supported contrary realistic agent induced higher level positive affect learners agent theoretical design considerations regarding agents visual discussed paper
introduction chronic hepatitis virus hcv infection prevalent among patients inherited bleeding disorders leading cause mortality aim evaluated efficacy safety plus ribavirin patients chronic hcv genotype infection inherited bleeding disorder methods administered weeks patients genotype infection weeks treatment experienced patients genotype infection patients genotype infection received plus ribavirin weeks respectively results majority treated patients severe bleeding disorder overall patients patients hiv sustained response weeks posttreatment patients genotype infection treatment experienced patients genotype infection patients genotype infection patients genotype infection treatment due adverse events aes frequent non bleeding aes fatigue headache diarrhoea nausea insomnia bleeding aes occurred patients one considered unrelated treatment conclusion treatment patients hcv genotype infection plus ribavirin patients genotype infection highly effective tolerated among inherited bleeding disorders
cadmium one toxic metals widely distributed freshwater marine environments received much attention toxicological perspective aim study assess effect species family used water pollution performed contamination fish days accumulation measured liver displayed significant increase concentration throughout experiment slightly higher levels liver except days partial length cdna cat characterized results mrna expression levels displayed regulation biomarker activities determined liver data displayed inhibition activities exposure significantly increased activities affect cat levels throughout experiment induction observed exposed fish regarding liver activity enzymes mda levels increased significantly beginning experiment except increased days contamination histological level fish exhibited pathological symptoms liver predominance disturbances changes liver results displayed able survive toxicity due various physiological adaptation mechanisms
seasonal affective disorder sad characterized depression specific seasons generally winter pathophysiological mechanisms underlying sad remain elusive due limited number animal models high availability validity show laboratory mice display changes depression like behavior brain serotonin content mice maintained short day conditions compared long day conditions demonstrated prolonged immobility times forced swimming test lower brain levels serotonin precursor tryptophan furthermore photoperiod altered multiple parameters reflective peripheral metabolism including ratio plasma sum large neutral amino acids compete transport across blood brain barrier responses circulating glucose insulin glucose load sucrose intake restricted feeding condition sensitivity brain serotonergic system administered glucose data suggest mechanisms underlying sad involve brain peripheral tissue network mice serve powerful tool investigating link seasons mood elsevier ltd rights reserved
reliability validity traditional limited arbitrary boundaries psychopathology often unclear boundaries disorders frequent disorder occurrence heterogeneity within disorders diagnostic instability went beyond evidence available structure psychopathology shaped variety considerations explain aforementioned shortcomings hierarchical taxonomy psychopathology model emerged research effort address problems constructs psychopathological syndromes components subtypes based observed symptoms grouping related symptoms together thus reducing heterogeneity also combines occurring syndromes spectra thereby mapping comorbidity moreover characterizes phenomena addresses boundary problems diagnostic instability review development relevant evidence new classification already covers forms psychopathology dimensional measures developed assess many identified components syndromes spectra several domains model ready clinical research applications promises improve research clinical practice addressing aforementioned shortcomings traditional also provides effective way summarize convey information risk factors etiology pathophysiology illness course treatment response greatly improve utility diagnosis mental disorders new classification remains work progress however developing rapidly advance mental health research care significantly relevant science
differences healthy subjects associated disease risks substantial interest clinical medicine based clinical presentations traditional chinese medicine healthy people nine balanced deficiency heat blood inherited special particular deficiency exhibit cold heat respectively however intrinsic molecular characteristics unbalanced phenotypes remain unclear determine whether gene expression based clustering based classification peripheral blood mononuclear cells pbmcs collected chinese han individuals deficiency balanced global gene expression profiles determined using plus array notably found gene expression based classifications reflected distinct based subtypes consistent clinical observation subjects deficiency tend toward obesity series clustering analysis detected several key lipid metabolic genes acyl coa atp binding cassette member regulated deficiency respectively findings suggest deficiency balanced unique entities mrna expression profiles moreover distinct physical clinical characteristics unbalanced explained part specific gene expression signatures copyright institute genetics developmental biology chinese academy sciences genetics society china published elsevier limited science press rights reserved
increasing levels criminal media shared peer peer networks pose significant challenge law enforcement agencies one main priorities investigators identify cases user actively engaged production child sexual abuse csa media indicators recent going child abuse although number monitoring tools exist detect activity networks typically rely hash value databases known csa media result tools able adequately thousands results retrieve identify new child abuse media released network paper present new intelligent approach incorporates advantages artificial intelligence machine learning theory automatically new previously csa media investigators additionally research extensively discussed law enforcement specialists different european countries approach implemented toolkit software package designed perform live forensic analysis network environment addition system offers secondary features showing line known csa files ability see files shared addresses used client finally evaluation real csa case data shows high degrees accuracy hands trials law enforcement demonstrate extant workflows authors published elsevier ltd
broad band solar thermal conversion materials highly desired solar energy harvesting purpose work demonstrate simple straightforward strategy engineer broad band solar thermal conversion stable two component containing copper oxide doped tin oxide nanoparticles prepared surface modification nanoparticles reference strong absorption visible region near infrared region contrary strong absorption near infrared region absorption visible region comparatively weak combination nanoparticles two component broad band absorption across visible near infrared region two component vol show absorption spectrum match solar spectrum give solar weighted absorption fraction compared respectively solar thermal utilization efficiency two component determined compared respectively enhanced solar thermal conversion properties two component attributed complementary optical absorption nanoparticles work provides promising strategy engineer solar energy harvesting
background tracking changes neural dynamics based neuronal activities critical step understand neurobiological basis learning animals dynamical neurobiological processes associated learning also time varying makes modeling problem challenging new method developed novel based time varying generalized modeling framework study time varying neural dynamical systems using natural train data time varying parameters model onto finite sequence basis functions time varying identification problem converted time invariant linear parameters one effective forward orthogonal regression algorithm aided mutual information criterion applied selection significant model terms refinement model structure generalized linear model fit approach finally employed parameter estimation train data results proposed based approach used identify synthetic input output trains spontaneous retinal train recordings proposed method gives excellent performance tracking either sharply slowly changing parameters high sensitivity accuracy regardless priori knowledge trains results indicate proposed method shown deal train data comparison existing methods proposed based approach compared several state art parametric estimation methods like descent point process filter polynomial expansion method conventional algorithm wavelet expansion method shown poor performance tracking time varying system changes synthetic train data due slow convergence adaptive filter methods although polynomial basis function method gave good parametric estimation results requires prior parameter estimation shown proposed based method track time varying parameter changes rapidly accurately conclusions based modeling framework developed paper provide computational modeling scheme investigating properties track general forms changes time varying neural dynamics also potentially applied investigate spatial temporal information underlying biomedical signals elsevier rights reserved
association air pollution bone health evaluated adolescents city study essentially ecological vitamin deficiency among adolescents reported higher rates polluted areas non polluted areas additionally residence polluted areas associated lower levels bone alkaline phosphatase purpose aim study evaluate association ambient air pollution bone turnover adolescents compare prevalence vitamin deficiency polluted non polluted areas methods cross sectional population based study conducted middle high school students girls boys winter study period detailed daily data air pollution obtained data collected air quality control company serum levels calcium phosphorus parathyroid hormone bone specific alkaline phosphatase vitamin osteocalcin cross linked total protein albumin creatinine obtained study group results vitamin deficiency prevalent polluted areas non polluted areas adjustment age sex residence polluted area showed statistically significant positive association vitamin deficiency statistically significant negative association bone turnover interestingly high calcium intake week protects effects air pollution bone turnover conclusions air pollution chief factor determining amount solar reaches surface thus atmospheric pollution play significant independent role development vitamin deficiency
recent years emergence many intelligent autonomous systems possible due tremendous advancement various technologies like computer vision automation control engineering sensor technology one intelligent system autonomous underwater vehicle ocean floor mapping technology success autonomous smart precise intelligent system depends accurate navigation unmanned vehicle longer period time precise objects detection ocean floor image processing paper describes various algorithms used purpose investigates computational dynamic system high computational payload requirement system parallel processing reconfigurable field programmable gate array proposed higher performance
article describes approach assessing maturity risk management manufacturing organization designing developing product risk management process maturity guarantees successful product design development terms cost schedule quality paper proposes risk management maturity model based six levels capability capability maturity model integration four dimensions organizations namely culture risk management process experience business applications model evaluates organization four dimensions capability levels determines stands terms capability ordinal scale end case study presented domain assembly auto evaluate risk management maturity assembly line
context information shapes spin states individual important study whole population main belt shape models available now reconstructed disk integrated inversion method aims want significantly current sample similar available models methods use inversion method derive new shape models spin states sparse time compiled database speed time consuming process scanning period parameter space use convex shape models use distributed computing project running open infrastructure network computing platform way period search interval divided hundreds smaller intervals intervals scanned separately different volunteers together also use alternative faster approach searching best period using model independently confirm periods found convex models also find rotation periods convex model approach gives many solutions results analysis data first derived new models almost number available models tested reliability results comparing models derived purely data based dense found rate false positive solutions low also present updated plots distribution spin pole confirm previous findings non uniform distribution spin axes however models reconstructed noisy sparse data heavily biased towards bodies high amplitudes conclusions database rich reliable source information spin states expect hundreds models numbers larger data set models able reconstructed data merged
objective etiology obsessive compulsive disorder assumed involve interactions genetically determined vulnerability factors significant environmental features aim investigate personality trait harm avoidance experience childhood contribute method total patients healthy comparison subjects unaffected first degree relatives patients participated study harm avoidance assessed using temperament character inventory severity childhood measured childhood trauma questionnaire results patients relatives showed elevated levels harm avoidance compared controls furthermore patients exhibited significantly higher scores relatives linear pattern observed throughout subscales harm avoidance remained stable controlling severity depressive symptoms regard childhood patients reported higher levels relatives controls conclusion results provide evidence stress model patients unaffected relatives share elevated levels harm avoidance supporting role harm avoidance heightened severity childhood adversity observed patients assumed biological underpinnings findings discussed
background become evident increased nitric oxide generation associated production reactive oxygen species postulated responsible several cytotoxic effects previously ascribed since cellular arginine uptake shown modulate nitric oxide synthase activity study effect arginine traffic renal cells methods arginine uptake cat cat mrna expression northern blotting analysis cat protein content using western blotting determined cells pre treated results induced significant increase arginine uptake cat mrna expression compared untreated cells contrast cat mrna expression protein abundance diminished conclusions rat cells arginine uptake via augmentation cat decreasing cat expression
objectives deficits recognition negative emotions emerge clinical diagnosis disease address emotion recognition deficits shown schizophrenia improved computerized training conducted study feasibility efficacy computerized training emotion recognition methods randomly assigned individuals early symptomatic training control group training group used self guided online training program training tool twice weekly weeks participants completed measures emotion recognition baseline post training time points participants training group also completed training adherence measures results participants training group completed seven eight sessions average results showed significant group time interaction indicating training associated improved accuracy emotion recognition conclusions although sample size small study demonstrates emotion recognition remediation using feasible terms training adherence evidence also suggests effective early symptomatic opening potential new avenue intervention study larger sample size needed replicate findings characterize durability generalizability improvements impact functional outcomes
cardiovascular risk factors aging dementia finnish population based study cognitively normal women self reported hormone therapy data use years information type available prescription register cognition assessed years use especially use estradiol alone among women bilateral associated better episodic memory although strong evidence protective effect estradiol cognition observed study improved global cognition among long term users suggests long term postmenopausal beneficial cognitive domains
purpose investigated efficacy alpha blockers different affinities alpha subtypes treatment benign prostatic enlargement complicated overactive bladder materials methods prospective open label randomized multicenter study outpatients untreated benign prostatic enlargement associated urinary urgency least per week overactive bladder symptom score greater patients randomly assigned receive per day per day changes parameters baseline weeks assessed based pss international prostate symptom score pss quality life voiding functions measured results efficacy analysis total patients included groups significant difference adverse effects observed groups mean pss pss quality life scores significantly improved groups statistically significantly greater improvement group group observed total pss quality life score urgency score blocker
paper outlines procedure computer controlled calibration combined zero dimensional one dimensional thermodynamic simulation model internal combustion engine ice main purpose calibration determine input parameters simulation model way achieve smallest difference results measurements results numerical simulations minimum consumption computing time innovative calibration methodology based novel interaction optimization methods physically based methods selected ice sub systems physically based methods used steering division integral ice several sub models determining parameters selected components considering governing equations innovative multistage interaction optimization methods physically based methods allows unlike use established methods rely optimization techniques successful calibration large number input parameters low time consumption therefore proposed method suitable efficient calibration simulation models advanced
objectives estimate relationship hiv natural history fertility duration infection east southern africa availability antiretroviral therapy assess potential biases estimates age specific using retrospective birth histories cross sectional pooled analysis prospective population based hiv cohort studies methods women aged years ever tested hiv included analyses antiretroviral treatment roll fertility rate ratios calculated see relationship duration hiv infection fertility adjusting background characteristics biases age specific estimates cross sectional surveys estimated person time cohort data simulate cross sectional surveys comparing fertility rate ratios true cohort hiv negative hiv positive women contributed births person years births person years respectively final dataset adjusting age study site year additional year since hiv associated confidence interval relative decrease fertility hiv positive women biases simulated retrospective birth histories resulted modest age groups longer duration infection associated greater relative fertility reduction hiv positive women considered creating estimates hiv prevalence among pregnant women prevention mother child transmission need course hiv epidemic antiretroviral treatment scale copyright wolters kluwer health inc rights reserved
video tool providing diagnostic information progress diseases cause regression eye movements parkinsons disease majority existing systems based sophisticated red devices study authors show based system provide similar accuracy head mounted based system also prove authors algorithm outperforms current state art methods popular dataset terms accuracy proposed system consists set image processing algorithms face detection facial features performed examinations patients suffering using system novo head mounted device sensor reference experiments obtained mean correlation results method novo shown accuracy visual system similar accuracy head mounted devices future plan extend experiments inexpensive high frame rate cameras potentially provide diagnostic parameters
introduction burn wound infection primarily caused aerobic bacteria followed fungi viruses worldwide decrease incidence bacterial infections due better patient care availability effective antibiotics consequently fungal burn wound infection shown increasing trend aim aim study assess frequency fungal infections thermal burn wounds respect age wounds total body surface involved depth assess common fungal pathogens materials methods study conducted patients admitted thermal burn wounds surgical unit taken local burn patient put sterile container sent section microbiology department examined direct microscopy culture studies agar medium section microbiology department results study incidence fungal infection burn wound patients came incidence fungal infection increased increase total body surface area increase depth age burn study maximum positive fungal cultures seen third week post burn period positive culture seen first week positive cultures seen second week candida albicans found common organism followed non albicans candida aspergillus conclusion concluded study incidence fungal infections thermal increased increase post burn period increasing depth candida albicans found common fungus
although research suggests misinformation provided influential obtained sources research compared effect information non social forms misinformation better understand influence compared influence misinformation influence misinformation provided across two experiments using paradigm found evidence particularly influential relative another social source post event misinformation fact source misinformation delivered less likely correctly recalled source misinformation delivered evidence misinformation delivered stronger effect accuracy confidence misinformation obtained either source alone finally results suggest opportunity provide early individual memory account protect effect subsequently encountered misinformation results important implications way criminal investigations conducted
background develop singapore chinese english versions psoriatic arthritis quality life scale equivalent met psychometric acceptability standards original measure methods translation original english chinese versions use singapore performed professional lay translation panels ten chinese speaking ten english speaking local patients interviewed assess face content validity psoriatic arthritis psa patients either chinese english speaking fulfilling classification criteria psoriatic arthritis invited participate validation survey clinical variables health assessment questionnaire medical outcome short form used comparator instruments convergent validity separate sample psa patients invited participate test retest study two weeks results validation sample included patients men mean age years excellent internal consistency cronbachs scores measure moderately correlated health status measures pain score scores patient physician global assessments scale able distinguish groups active inactive disease assessed composite scores minimal disease activity test retest reliability excellent conclusions study provides evidence adapted english chinese versions used clinical studies psa patients singapore
introduction unlike molecular biology studies analysis ancient dna requires special infrastructure methodological conditions guarantee quality results one main criteria dna quantification quantitative real time pcr often used given sensitivity specificity nevertheless implementation conditions methodologies fulfill criteria imply higher costs objective develop simple less costly method mitochondrial dna quantification suitable highly degraded samples materials methods proposed method based use mini primers specific amplification short fragments mitochondrial dna subsequent purification amplified fragments allows standard curve constructed concentrations accordance state degradation samples results proposed method successfully detected dna ancient samples including bone remains tissue dna inhibitory substances also detected conclusion proposed method represents simpler cost effective way detect low amounts tool differentiate dna free samples samples inhibitory substances
photovoltaic systems maximum power point tracking indispensable task date various techniques proposed literature using classical artificial intelligence methods however techniques tested different systems different environmental conditions work attempt summarize give comprehensive comparative study adopted artificial intelligence based techniques techniques described based proportional integral derivative pid fuzzy logic artificial neural network ann genetic algorithms particle swarm optimization pso developed controllers tested weather profile photovoltaic system composed module buck boost converter load initially modelling simulation system performed using matlab simulink environment thereafter sliding mode control applied converter order improve performance stage different steps development technique presented simulation performed confirm validity proposed controllers variable temperature solar irradiance conditions finally comparative study carried order evaluate developed techniques regarding two principal criteria performance implementation cost performance evaluated using comparative analysis tracking speed average tracking error variance efficiency estimate implementation cost classification carried according type used sensors type circuitry software level complexity recommendations expected useful researchers area validity technique given last section
background leukocyte derived proteins interleukin vascular endothelial growth factor vegf markers inflammation angiogenesis ultrasound sensitive detection power doppler objective present study explore associations vegf erythrocyte sedimentation rate reactive protein comprehensive assessment patients rheumatoid arthritis starting biologic disease modifying anti rheumatic drug treatment methods total patients assessed clinical examination biomarker levels baseline months initiation assessment joints tendon scored semi quantitatively scale european league response calculated statistical assessments performed explore associations biomarkers sum scores included spearmans rank correlation analysis linear linear mixed model regression analyses results showed overall strongest correlations sum scores joint counts examinations association sum scores remained adjusted age sex disease duration markers regression analysis baseline decreased first month predictive response decreased sum scores months conclusions highest association predicted treatment response thus considered marker evaluating inflammation responsiveness patients treatment
recurrent genetic abnormalities great significance refined diagnosis assessment prognosis leukemia conventional nested reverse transcription pcr labor intensive time consuming methodswe developed novel dual color taqman probe based real time pcr method simultaneous screening fusion transcripts parallel reactions method tested validated cell lines carrying known fusion transcripts patient samples resultsa multiplex real time pcr method successfully developed rapid detection fusion genes validated commonly detected fusion genes intra assay reproducibility assessed frequent rearrangements ranged coefficient variation cycle threshold reproducibility ranged five separate experiments lowest detection limit tested ranged validation method patient samples showed specificity excellent conventional nested pcr believe method easily applicable cost effective clinically useful rapid screening fusion genes initial diagnostic phase leukemia use also extended monitoring minimal residual disease
purpose study investigate prevalence gambling disorder comorbid psychiatric disorders homeless population identify features related potential subtypes baseline participants administered structured interview including socio demographic sections national comorbidity study interview seven diagnostic sections diagnostic interview schedule alcohol drug abuse sections composite international diagnostic interview substance abuse module sam homeless supplement nine months post baseline assessment participants administered additional family history questions south gambling screen participants epidemiologic sample african american homeless individuals grouped lifetime non recreational problem recruited street homeless results indicate lifetime rates sub clinical problem disordered gambling significantly higher general population problem likely non problem meet diagnostic criteria antisocial personality disorder post traumatic stress disorder bipolar disorder psychiatric disorder likely non use illicit drugs meet criteria abuse dependence nicotine alcohol substance study provides evidence problem gambling significant public health issue among african american homeless population homeless services include assessment problem gambling along psychiatric disorders referrals resources treatment programs future studies explore relationship onset course problem gambling psychiatric disorders racial differences gambling patterns problem severity time
novel three dimensional dna network structure amplification strategy employed design lateral flow biosensor introducing coated gold nanoparticles paper act amplification probes aggregate numerous gold nanoparticles test line forming dna network structure presence target sensitive detection nucleic acid point care analysis significant infectious agent early diagnosis treatment genetic diseases use particles rapid point care lateral flow assays lead linear range limit detection without polymerase chain reaction pcr proposed method increase sensitivity orders magnitudes traditional sandwich assays labeled furthermore assay good reproducibility stability prove practical diagnostic applications
work intended design integration sensor non invasive blood glucose detection low power consumption fast detection speed high accuracy based modified conservation energy metabolism theory blood glucose level acquired multi linear regression equation rate human metabolism blood flow oxygen saturation hemoglobin pulse frequency physiological parameters obtained size integrated temperature sensors humidity sensors radiation sensors dual wavelength photo detectors healthy volunteers involved preliminary clinical experiment blood glucose concentrations ranging compared automatic biochemical analyzer aba gold standard correlation coefficient aba strong correlation good coherence moreover multi physiological parameters measured including body temperature local metabolic rate blood flow oxygen saturation heart rate simultaneously
introduction uses cell therapy strategies treat diseases therapies surgeons aim reconstruct natural regulate activity dental stem cells methods searched articles pubmed using key words regenerative dental stem cell biology articles reviewed factors influence histologic results preclinical dental treatments use regenerative procedures results several factors origin stem cells scaffolds used size lesions considered influence histologic appearance regenerated pulp complex treatments information accumulating transcription factors generate pulp complex survival trophic factors benefit niche recovery histologic results conclusions article discuss stem cells influence molecule release pulp regeneration survival stem cells need markers assess treatments histologically vivo amplification appropriate dental stem cells search scaffolds storing molecular diversity use transcription factors histologic markers necessary improve future preclinical experiments
voltage mode multiphase sinusoidal oscillator realized using second generation current grounded passive elements introduced paper proposed topology suitable realizing oscillators odd even number phases without modifying core topology non inverting current required construction oscillators topology benefit discrete component implementation point view behavior proposed topology evaluated experimental results cases three six phase oscillators elsevier gmbh rights reserved
across tree life calcium essential element used cells respond adapt constantly changing environments organisms plays fundamental roles fertilization development adulthood inability cells regulate lead pathological conditions ultimately cell death one pathological condition manifested parkinsons disease second common neurological disorder humans characterized aggregation protein alpha synuclein review discusses current evidence pathogenesis parkinsons disease understanding mechanisms signaling contributes progression disease crucial development effective therapies combat devastating neurological condition
according switching rules using method signal flow graph combined probability generating function paper derives formulas scheme operating characteristic curves average scheme sample number based formulas calculate performance measures using sas code
thyroid hormone essential metabolism nerve excitability physical development congenital hypothyroidism leads dysfunction neuronal migration thyroid hormone deficiency even delays formation development serious congenital hypothyroidism congenital hypothyroidism presents higher rate incidence infants common causes mental retardation fibroblast growth factors endogenous metabolism regulate factor increases energy consumption reduces blood lipid triglyceride low density lipoprotein levels enhances capacity fat cells absorb glucose suppresses secretion purpose study investigate changes level efficacy mice congenital hypothyroidism therapeutic efficacy conducted intravenous injection manner congenital hypothyroidism mouse model therapeutic outcomes mice congenital hypothyroidism assessed animals behaviours results found levels significantly lower serum thyroid congenital hypothyroidism mouse model healthy subjects observed tsh regulated thyroid treatment serum levels concentration thyroid higher control groups treatment serum levels thyroid positively related thyroid stimulating hormone tsh thyroxine respectively multiple linear regression analysis showed hypothyroidism decreased independent factors influencing serum tsh levels taken together provided evidence protein diagnosis potential efficacy congenital hypothyroidism
cloud computing distributed computing model lot drawbacks faces difficulties many new innovative emerging techniques take advantage features paper explore security threats risk assessments cloud computing attack mitigation frameworks risk based dynamic access control cloud computing common security threats cloud computing explored threats addressed acceptable measures via governance effective risk management using tailored security risk approach existing threat risk assessment schemes cloud services use thinking approach develop theoretical solutions minimizing risk security minimal cost study propose improved attack defense tree mechanism designated solving problem cloud computing environments
based depth analysis basic principle non stationary parallel hot wire method existing measuring standards foundation heat transfer differential mathematical model hot wire cylindrical coordinates research made measurement method solid materials thermal conductivity thermal diffusivity temperature measuring points originally arranged parallel hot wire changed specimen thickness direction combined computer programming numerical algorithms used directly measure materials thermal conductivity thermal diffusivity without looking table analyzes detail effect heat penetration measurement results explores treatment measures develops device thermo physical properties measurement measuring experiments conducted thermo physical properties glass others experimental results close compliance individual thermo physical properties literature values less relative error
article argues study representations landscapes aided enriched application digital geographic technologies example article focuses methods preliminary findings atlas landscapes portugal going project aims study representations portugal explore connections social environmental past present integrates traditional reading practices distant reading approaches along collaborative work relational databases geographic information systems gis order classify analyse works portuguese literature according set ecological socioeconomic temporal cultural themes argue herein combination qualitative quantitative methods response difficulty obtaining external funding lead increased productivity pursuit new research goals creation new knowledge natural cultural history proof concept article presents two initial outcomes project case study documenting evolving case study exploring representation portuguese literature
objective deep brain stimulation established adjunctive surgical intervention treating parkinsons disease motor symptoms surgical targets nucleus appear equally beneficial treating motor symptoms effects symptoms clear lower urinary tract symptoms luts common complaint given prior data aimed explore potential benefits luts targets methods performed prospective clinical trial evaluating luts patients targets pre post using validated surveys participants already target selection predetermined study entry luts evaluated using american association quality life score qol overactive bladder questionnaire oab sexual health inventory men results participants underwent patients demonstrated moderate baseline luts qol score significantly improved post analyzed target showed significant change qol significant differences scores post noted either target conclusion patients moderate luts notable improvements qol luts post total sample target differences effects luts targets require larger blinded studies
scope various biological effects postulated human milk deduced vitro animal epidemiological studies little known metabolic fate vivo breast fed infant presented methods results human milk infant urine collected ten mother child pairs analyzed maldi tof accompanied high performance anion exchange chromatography pulsed detection previously detected intact small complex infant urine absorbed gut verified via intrinsic labeling current work reveals presence novel metabolites urine breast fed infants novel metabolites identified like structures produced infants gut microbiota finding specific urine infants fed negative milk suggested modification infant conclusion study reveals new insights metabolism neutral exclusively breast fed infants provides indications multiple factors influencing metabolism functions considered future vivo investigations
purpose purpose paper examine relationship major personality dimensions attitudes towards war design methodology approach three samples two consisting british psychology students one israeli students responded measures five factor inventory trait form general survey including attitudes towards war specific attitudes towards war policy findings general attitude measures associated specific attitudes associated consistently personality dimensions research limitations implications descriptive findings generalize need measured studies attitudes related war conflict structural violence practical implications practitioners education first need address high low integrative complexity also structural violence related instance poverty prejudice discrimination require comprehensive approach including collaborative work clinical psychologists applying implicit explicit assessment tools originality value documenting links lack among personality variables attitudes towards war practical theoretical value contribute organizational schemes shaped personality structure bearing implications terms paradigm results show individual differences associations among variables relating likelihood parties differentially likely find negatively positively situations carrying effective instead actions
background hypothalamic pituitary adrenal axis hpa axis known phenomenon bipolar disorder however also described found associated depression low quality life cardiovascular risk factors patients although pathophysiology related largely unknown associated chronic stress exposure inducing initial rise cortisol long term stress result transition patients throughout life often exposed chronic stress therefore hypothesized higher age associated lower hpa axis activity especially among patients without previous mood stabilizing treatment methods cross sectional study consisted bipolar outpatients controls low dose dexamethasone suppression test used measure hpa axis activity results patients showed negative association post cortisol age nmol per year association gradually increased subgroups naive lithium nmol per year mood nmol per year patients exhibiting characterized younger age female gender whereas patients exhibiting characterized long disease duration without prophylactic lithium treatment absence current lithium medication limitations cross sectional study design conclusions negative association hpa axis activity age rendering patients risk developing association pronounced among patients without previous current lithium prophylaxis
utilised treatment various neurological disorders including alzheimers disease reported potent neuroprotective effects preventive effects amyloid beta beta induced alzheimers disease related cognitive impairment underlying mechanisms effects characterised five month old transgenic mice randomly assigned vehicle group two either per day groups weeks treatment observed beneficial effects per day including learning memory deficits reducing plaque burden beta levels furthermore expressions camp responsive element binding protein brain derived neurotrophic factor bdnf significantly increased disturbance akt beta signalling pathway markedly ameliorated hippocampus treated per day group data suggest potential therapeutic agent
difficult explore adequately respiratory posterior wall muscles opening becomes develop small sized mostly asymptomatic whereas large sized lead various nasal symptoms depending localization report present year old case huge presented clinic complaints nasal obstruction periodic headache hearing loss left ear underwent total excision endoscopy diagnosis treatment characteristics case presented review literature
despite established practice disabilities service systems person centered planning relatively new practice behavioral health system result little known barriers mental health organizations face implementing person centered recovery planning fill gap results presented qualitative analysis nine focus groups three public mental health organizations texas implementing least years findings suggest organizations experienced distinct barriers implementation categorized consolidated framework implementation research domains intervention characteristics outer setting inner setting characteristics individuals implementation process half barriers fell within inner setting domain suggesting implementation efforts flexible adaptable organizational culture context one quarter barriers fell domain characteristics individuals involved intervention suggests implementation efforts assess impact staff consumers implementation success
software engineering standards often utilize different underpinning ontologies sometimes differ standards better adoption industry standards use domain ontology advocated paper apply approach proof concept project recommend creation single underpinning abstract domain ontology created existing iso iec standards including iso iec supplemented sources appropriate useful adoption single ontology permit engineering existing international standards domain ontology focussed standards inter operate elsevier rights reserved
participatory approaches elicit information multiple stakeholders planning implementing resource management systems elicited information often associated significant variability public participation geographical information science gis gis solutions reduce variability helping stakeholders measure factors involved provide elicited information propose quality function deployment based participatory framework developing gis solutions demonstrated using case study enhance existing gis solution rainwater harvesting systems indian villages novelty proposed framework identifies metrics carries comparative analysis three existing solutions participatory rural appraisal participatory mapping gis case study gis scored less participatory mapping scored less usability improve gis aspects easy use mobile web based free open source gis solution watershed gis developed scored better three existing solutions usage resulted substantial reduction variability criteria values thus better ranking alternatives average coefficient variation decreasing
present hispanic male clinical molecular diagnosis syndrome patient born multiple anomalies entirely typical patients including large prostatic left addition demonstrated endocrine anomalies including low random cortisol level adrenal insufficiency low testosterone level knowledge first report prostatic second report unique disease causing mutation likely arose novo mother deletion insertion leads residue premature stop codon five amino acids residue normally cleaved although significance novel mutation respect patients multiple anomalies unknown present case perinatal course patient unique features confirmed molecular diagnosis wiley periodicals inc
standard care united states uses two step screening diagnosis approach gestational diabetes mellitus aimed assess impact interval screening diagnosis maternal perinatal outcomes materials methodsthis retrospective cohort study pregnancies complicated single tertiary center women divided three groups based interval screening diagnostic tests days maternal outcomes mode delivery white class perinatal outcomes included preterm birth birth weight birth injury review revealed women diagnosis included analysis days women within days women days group maternal perinatal outcomes similar groups including risk delivery preterm birth birth injury time interval screening diagnosis negatively affect maternal perinatal outcomes pregnancies complicated
genotype phenotype hypotheses developed explain rapid increase diabetes obesity developed countries around world subsequent research focused early developmental origins metabolic syndrome metabolic disease goal manuscript review emerging line research uses similar framework understand early developmental origins eating related phenotypes primary relevance many psychiatric disorders given important role environmental adversity various psychiatric disorders involve early age onset likely several mechanisms relevant regard understanding early origins increased eating behaviour based model point way highly targeted preventative interventions critical periods development provide new way addressing common difficult treat disorders
present study examines indian publications vitamin deficiency covered scopus database experiencing annual average growth rate citation impact per paper international collaborative publication share global publications share vitamin deficiency came several countries top productive countries accounted share global publications share global citations large number indian organizations authors participated indian research vitamin deficiency top organizations authors contributed publications share citation share respectively indian output citations medicine among subjects contributed largest publications share followed biochemistry genetics molecular biology pharmacology toxicology nursing agricultural biological science immunology microbiology total indian publications appeared several journals top journals contributed share output top highly cited papers registered citations together contributed citations leading average citation per paper concludes urgent need frame national policy area undertake recognize vitamin deficiency public health problem allocate healthcare area
study performed culture identify germ cells isolated genital sheep fetus growth characteristics sheep detected different culture systems culture media resources state cells obtained embryonic germ cells identified morphology enzymology immunofluorescence results showed sheep cell colonies typically like compact regular edges alkaline phosphatase staining reaction weakly positive cells expressed kit oct immunofluorescence detection weakly positive whereas positive
objective examine relationship public health system network density organizational centrality public health systems public health governance community size health status three public health domains data sources study setting fall winter primary data collected organization composition eight rural public health systems study design multivariate analysis network graphical tools used case comparative design examine public health system network density organizational centrality domains adolescent health senior health differences associated public health governance centralized decentralized urbanization health status public health domain collaboration area described data collection extraction methods site visit interviews key informants local organizations web based survey administered local stakeholders principal findings governance urbanization public health domain health status associated public health system network structures centrality local health departments varies across public health domains urbanization collaboration greater assessment assurance advocacy seeking funding conclusions public health system organization related improved health status studying individual system components prove insufficient studying impact public health systems
domain containing involved development progression multiple cancers however function significance prostate cancer remains unclear study investigated function prostate cancer regulation micrornas mirnas found highly expressed prostate cancer cells knockdown small interfering rnas markedly suppressed proliferation invasion wnt signaling prostate cancer cells identified target gene mir bioinformatics analysis dual luciferase reporter assay real time quantitative polymerase chain reaction western blot analysis furthermore expression inversely correlated mir expression prostate cancer tissues overexpression mir significantly inhibited proliferation invasion wnt signaling prostate cancer cells however inhibition mir exhibits opposite effects moreover overexpression significantly reversed inhibitory effects mir expression taken together results suggest plays important role regulating prostate cancer cell proliferation invasion targeting mir promising therapeutic strategy prostate cancer elsevier inc rights reserved
growing number studies examined immigrant paradox respect health behaviors united states however little research attention afforded study adverse childhood experiences ace neglect physical sexual abuse violence among immigrants united states present study using waves data national epidemiologic survey alcohol related conditions aims address gaps comparing forms ace first second generation immigrants native born american adults united states also examined latent structure ace among immigrants conducted analyses assess psychiatric correlates identified latent classes exception neglect prevalence ace markedly higher among native born americans second generation immigrants compared first generation immigrants four latent classes adverse experience emotional physical abuse family violence global adversity latter three classes greater likelihood diagnosed mood anxiety personality substance use disorder report violent non violent antisocial behavior consistent prior research examining associations immigrant paradox health outcomes results suggest first generation immigrants united states less likely experienced physical sexual abuse domestic violence however likely due cultural circumstances first generation immigrants likely report experiences deemed western standards
objectives purpose conduct systematic review published articles aiming prevent sports injuries based psychological interventions perform meta analysis effects interventions news different kinds sport injury prevention strategies accomplished neuromuscular warm programs recently psychological intervention studies completed purpose preventing sports injuries evident predictor stress consequently psychological injury prevention interventions incorporate stress management psychological skills training prospect projects electronic databases suitable sport psychology journals searched published studies screened articles potentially eligible articles seven articles substantial information papers authors able provide data request finally included conclusion result using random effect model showed total effect size result indicates psychological injury prevention interventions large effect reducing number injuries sport population elsevier masson sas rights reserved
analog signal processing offers advantages power consumption viewpoint real time detection method described paper detects comparing eeg signal energies different locations brain according signature first proposed strategy appropriate eeg bands per channel means band pass filters next extracted energies compared counterparts different healthy location detected higher theta gamma energies associated lower alpha energy comparison corresponding signal energies healthy brain region present verify detector performance cmos detector circuit designed implemented technology verified means simulations cadence using final circuit operates supply consumes applicability detector verified means circuit simulations real neural waveforms able successfully detect
hepatitis virus hcv envelope glycoprotein complex composed subunits receptor binding protein major target neutralizing antibodies whereas functions remain poorly defined took advantage recently published structure terminal region functions glycoprotein residues within amino acid region context infectious clone phenotypes mutants characterized determine effects mutations virus entry replication assembly furthermore biochemical approaches also used characterize folding assembly thirteen mutations led viral attenuation inactivation interestingly two attenuated mutants less dependent cellular entry cells instead viruses relied indicating shift receptor dependence two mutants target cell line unexpected phenotype also observed mutant longer infectious still showed good level core protein secretion furthermore genomic rna absent viral particles indicating mutation leads assembly release viral particles devoid genomic rna finally change subcellular hcv rna observed mutant unique observation highlights first time cross talk hcv glycoprotein genomic rna hcv morphogenesis importance hepatitis virus hcv infection major public health problem worldwide encodes two envelope proteins play major role life cycle virus extensively characterized whereas remains poorly understood investigated functions using site directed mutagenesis context viral life cycle results identify unique phenotypes unexpectedly two mutants clearly showed shift receptor dependence cell entry highlighting role modulating hcv particle interaction cellular receptor importantly another mutant led assembly release viral particles devoid genomic rna unique phenotype characterized observed change subcellular hcv rna unique observation highlights first time cross talk viral envelope protein genomic rna morphogenesis
carcinoma unique type hepatocellular carcinoma distinctive young patients without underlying liver disease characteristic large neoplastic cells dense fibrosis expression activation protein kinase often formation carcinoma similar prognosis conventional hepatocellular carcinomas arising non livers current american joint cancer committee staging system provide optimal stratification patients carcinoma alternate systems considered future effective treatment carcinoma complete resection novel therapies horizon investigation molecular biology carcinoma continues elsevier inc rights reserved
kinetic glycol ether derived glycol ether acetate parent compound following intravenous administration rats evaluated addition vitro hydrolysis rates blood liver tissue rats humans determined blood kinetics determined following administration rats low body weight high dosages respectively blood time courses elimination dosages compounds identical half lives elimination following administration calculated min respectively rat human vitro hydrolysis rates determined incubation whole blood liver rate loss rapid rat blood human blood hydrolysis half lives min human blood min rat blood concentrations respectively contrast rate loss human rat liver similar min min respectively data demonstrate rapid hydrolysis vivo parent glycol ether kinetics derived identical study supports use toxicological database surrogate
investigate correlation microstructural parameters csf pressure macroscopic changes assessed diffusion tensor imaging dti patients idiopathic intracranial hypertension three patients age sex body mass index bmi matched controls underwent high resolution imaging optic nerve pituitary gland dti data permutation analysis performed whole brain roi analysis performed optic nerve optic radiation dti measurements correlated morphometric measurements csf opening pressure headache intensity reliability diagnostic performance dti parameters assessed using roc analysis dti metrics revealed significant reduction fractional anisotropy optic nerve patients contrast systematic regional variations patients controls neither observed whole brain analysis optic radiation values optic nerve show significant correlations optic nerve diameter correlation alterations values optic radiation whole brain show significant association morphometric alterations diameter height csf opening pressure headache intensity conclusionsthe results indicate associated microstructural changes optic nerve alterations direct consequence chronically elevated intracranial pressure
adolescents access use new media technology cell phone personal data computer internet access rise explosion technology brings potential benefits risks attention growing risk adolescents become victims aggression peers new technology september centers disease control prevention panel experts technology youth aggression examine specific risk special issue journal adolescent health presents data recommendations future directions discussed meeting articles journal support argument electronic aggression emerging public health problem need additional prevalence etiological research support development evaluation effective prevention programs society adolescent medicine rights reserved
trauma exposure smoking occur high rate however little understanding mechanisms underlying clinically significant relation present study examined perceived stress explanatory mechanism linking posttraumatic stress symptom severity smoking specific avoidance perceived barriers smoking cessation negative affect reduction negative reinforcement smoking among trauma exposed smokers participants trauma exposed treatment seeking daily cigarette smokers female age results indicated posttraumatic stress symptom severity indirect significant effect dependent variables via perceived stress present results provide empirical support perceived stress underlying mechanism indirectly explains posttraumatic symptoms relation smoking specific avoidance perceived barriers smoking cessation negative affect reduction negative reinforcement among trauma exposed smokers findings suggest clinical utility targeting perceived stress among trauma exposed smokers via stress management skills training elsevier ltd rights reserved
past two decades significant improvement medical field elucidating underlying pathophysiology genetics disease adrenal insufficiency disease rare disease incidence cases diagnosis delayed clinical presentation mimics gastrointestinal disorder psychiatric illness report case disease presenting acute pain abdomen mimicking clinical presentation acute
paper presents two dimensional numerical model random wave transformation focus model calibration verification laboratory field data model based energy balance equation including diffraction dissipation terms energy dissipation determined based formulation new expressions stable wave height decay coefficients coefficients estimated based local slope offshore wave conditions model calibrated several data sets large scale sediment transport facility coastal hydraulics laboratory usa model verified large number data sets including data cases structures laboratory data great wave field data netherlands usa mexico validation showed model reproduce observations relative root mean square error varies laboratory data field data coefficient determination varies demonstrating good agreement model measurements
background congenital hypothyroidism common endocrine diseases one major causes preventable mental retardation study conducted investigate prevalence transient permanent congenital hypothyroidism province iran materials methods cross sectional study registered congenital hypothyroidism health centers cities covered university medical sciences entered study demographic laboratory information neonates collected entered analyzed using student test chi square statistic value less considered results overall incidence rate province respectively per neonates period number diagnosed patients cases including boys girls cases urban areas total patients permanent significant difference gender location type season birth transient permanent types disease significant statistical relationship congenital hypothyroidism conclusion prevalence congenital hypothyroidism province significantly higher global country levels emphasize continuation reinforcement screening program infants therefore complementary studies research priorities health system province order clarify environmental genetic factors related
night eating syndrome commonly assessed using night eating questionnaire validated scale symptom severity assess diagnostic criteria night eating diagnostic questionnaire assesses diagnostic criteria fully validated study purpose establish convergent validity also expected higher associated elevated depression poorer sleep quality food addiction bmi studies students community members administered pittsburgh sleep quality index self report depression scale sds food addiction scale convergent validity demonstrated scores significantly positively correlated good agreement diagnosis diagnosed met threshold score participants met threshold score meet diagnostic criteria revealed higher associated higher sds scores poorer sleep quality full syndrome associated higher bmi community group unlike student group scores questionnaires higher community group discrepancies diagnosis due differences construction questionnaires specifically due designed diagnosis provides convenient global score severity whereas shows convergent validity provides clinically useful diagnostic categories elsevier ltd rights reserved
image mosaic engine designed scalable toolkit written performance portability across platforms fits images code freely available widely used communities research product generation developing next generation cyber infrastructure recently begun finding applicability field visualization development come toolkit design allows easy integration scalable systems process data subsequent visualization client toolkit includes visualization tool suitable automation integration python creates single command complex multi color images coordinate displays labels observation includes adaptive image histogram method preserves structure image dynamic range toolkit contains functionality originally developed support creation management also offers value visualization background algorithm reveals structure image tools creating versions large images version offers support visualizing data written scheme functionality processing organizing images comply scheme required consumption world wide four online allow readers reproduce extend visualizations presented paper
objectives race risk factor angioedema primary aim examine relationship race ethnicity risk factors angioedema study retrospective case control study design data extracted clinical looking glass utility data collection management tool captures data electronic medical record systems within healthcare system cases emergency department visits primary secondary international classification diseases ninth revision code diagnoses angioedema adults aged years january december three centers new york controls random sampling adult visits period primary analyses angiotensin converting enzyme inhibitor ace black race evaluated synergy influence different risk factors development angioedema evaluated using logistic regression models finally race ethnicity explored evaluating effect modification stratification models race ethnicity categories cases controls randomly selected larger control pool ace use odds ratio confidence interval hypertension black race strongest risk factors ace use black race synergistic race ethnicity effect certain risk factors ethnicity acts effect particular angioedema risk factors two strongest risk factors ace use black race synergistic
genetic structure european populations throughout species range examined using mitochondrial dna seven microsatellite loci ten mitochondrial haplotypes detected suggesting three lineages likely early middle three lineages geographically correspond three regions drainage including system delta system system high genetic diversity observed using mtdna confirmed microsatellite data suggesting existence populations studied area isolation migration model showed migration rates populations generally low highest according inferred relative population splitting times likely spread eastern part species range west also showed highest genetic diversity largest population size reported time calibrated phylogeny separation european american occurred roughly end late first half highest probability density taking results account appropriate guidelines proposed european populations
virtue based approaches engineering ethics recently received considerable attention within field engineering education virtue ethics engineering argue approach practically superior traditional approaches engineering ethics including study professional codes ethics normative theories behavior paper argues virtue based approach interpreted current literature neither practically effective significant subpopulation within engineering engineers high functioning autism spectrum disorder asd main argument adopting character based approach successfully applied engineering traditional rule based algorithmic ethical approaches problematic virtue based view furthermore without addressing concerns wide adoption virtue based approach engineering ethics potential isolate individuals asd contributions moral practice end paper gestures towards way incorporating important insights virtue ethics engineering inclusive asd
solution proposed make use rainwater thermal energy highly areas demonstrated stormwater heat represents additional site renewable energy available hot water production proposed solution increases multi functionality urban infrastructure essentially used mitigate impacts extreme climate events integrated system model applications correspond local area conditions north eastern region study considers optimal collection stormwater maximizing water absorbed heat usage relation hot water consumption different building types residential public commercial two key parameters stormwater volume storage tank rainwater catchment area determined genetic algorithm finds number storage tank corresponding rainfall statistics hot water consumption buildings system cumulative expenses related stormwater storage rainwater harvesting expenses
background since treatment guidelines atopic dermatitis released korean atopic dermatitis association work group several advances management objective aimed establish updated evidence experience based treatment guidelines korean methods collected database references relevant systematic reviews guidelines regarding general management skin care avoidance factors education psychosocial support use topical anti inflammatory drugs evidence statement graded strength recommendation statement classified thirty nine council members participated three rounds voting establish expert consensus recommendations results basic treatment includes proper skin care avoidance factors proper education psychosocial support use regular use steroid effect reduces relapse episodes short long term use topical corticosteroids inhibitors improves symptoms encouraged use active proactive treatment wet therapy used rapid recovery acute exacerbation topical anti drugs recommended treatment conclusion report provides date evidence experience based treatment guidelines regarding general management topical treatment addition average agreement scores obtained panel experts based korean healthcare system patient adherence presented
food protein induced non ige cell mediated food allergy severe lead shock despite potential reactions awareness low high quality studies providing insight pathophysiology diagnosis management lacking clinical outcomes poorly established consensus document result work done international adverse reactions foods committee american academy allergy asthma immunology international association advocacy group first international evidence based guidelines improve diagnosis management patients research prevalence pathophysiology diagnostic markers future treatments necessary improve care patients guidelines updated periodically evidence becomes available
objective sudden cardiac arrest caused cardiac arrhythmias leading causes death worldwide implantable considered standard care patients increased risk arrhythmias however icd patients experiences psychological distress post icd implantation web based distress management program icd patients developed mitigate anxiety depression enhance health related quality life icd patients study investigates months outcomes method total consecutive icd patients referral hospitals netherlands randomized either usual care group patients group received online weeks fixed behavioral treatment based problem solving therapy patients usual care group receive care usual results current findings show significant difference anxiety depression quality life usual care group months conclusions clinical trial web based behavioral intervention icd patients web based treatment superior usual care long term regarding patient reported outcomes future studies warranted examine applicability blended care models focus program order increase adherence improve outcomes
combined cooling heating power system plays significant role efficient usage energy field small scale power system application ranging residence utilities paper new system proposed consists power generation unit absorption storage tank ground source heat pump substitute conventional electric auxiliary supply deficient cooling heating load study three basic load following strategies following electric load following thermal load following hybrid load employed analyze annual total cost operational cost cost carbon dioxide emissions primary energy consumption based case study regional energy system singapore eco city evaluated case carbon electricity feed considered compare performances following maximum electric efficiency max strategy results show proposed system performed cost reduction increased except max strategy carbon electricity feed carbon electricity feed considered performances max strategy best otherwise application better finally max strategy sensitivity analysis performed results presented varying electricity gas price elsevier ltd rights reserved
purpose substantial number elderly people suffer cognitive impairment dementia considered various risk factors including dysfunction however association cognition inconclusive objectives systematic review provide overview literature association cognitive function association dementia incidence elderly people materials methods searches conducted five electronic databases pubmed embase cochrane library pro quest publications selected met following criteria published written english assessed associations cognitive function cognitive decline dementia among population years old included publications analyzed study design main conclusions strength evidence two reviewers screened abstracts full text articles abstracted data performed quality assessments using critical appraisal tool results total articles cross sectional prospective cohort studies evaluated poorer associated lower cognitive function cross sectional studies decline prospective studies poorer one significant risk factors dementia mild memory impairment cross sectional studies incidence dementia prospective studies conclusions studies point positive association cognitive function including dementia among elderly people elsevier ireland ltd rights reserved
face recognition widely used many application areas photo management information security rapid growth devices social networks bring new challenges face recognition algorithm design system engineering effective device face recognition model simple lightweight also needs handle large variations background image size etc paper tries address two problems system perspective employ simple linear model face recognition generated svm classifier whether pair face subject make classifier generalized potential inter face intra face variations train face pairs many potential problems arise large scale training procedure examples training set large fit single machine computation requirement huge takes many days complete training makes difficult algorithm developers experiment tune model effectively overcome obstacles paper proposes large scale face recognition training system called system takes advantage massive data parallelism available problem utilizes distributed compute cluster perform model training run system intel cluster model development tuning year using train face recognition model embedded devices achieves state art accuracy high scalability face verification rate false accept rate far benchmark nearly linear scalability tens hundreds nodes
biomass one important means realize effective treatment efficient utilization biomass wastes materials therefore great practical significance research process mechanism biomass wood renewable material rich source kind raw material among lots biomass know difference composition aspects characteristics different tree species obvious differences however even kind wood show different characteristics products process due significant differences aspects microstructure chemical composition amount component studied paper experiment kind common taken test material whose clearly distinct order research differences ftir method used obtain thermogravimetric curves volatile process results elucidated content cellulose extracts remarkably effect account higher content showed higher weight loss ratio early late stages higher content extracts increased weight loss ratio medium stage reduced differences contrary cellulose obvious weight loss similar higher weight loss ratio curve addition infrared spectrum indicated produced almost differences amount came maximum weight loss velocity produced increased significantly moreover produced organic compounds produced water
last years increased dramatically popularity evolved leading sporting events competitive year round sport involving complex consequently injuries steadily increased years number severity sprains strains lower extremities common injuries although overall injury rate remains relatively low accounted approximately catastrophic injuries high school girl athletes past years risk factors injuries include higher bmi previous injury surfaces performing supervision low level training experience policy statement describes epidemiology injuries provides recommendations injury prevention pediatrics
paper presents use structural responses monitor progress construction processes methodology implemented girder used construction rail project strain based wireless sensor network used data acquisition structural responses girder used identify state construction conventional system identification methodology tested application accurate inferring stage construction therefore modified system identification strategy using derived features heuristics used infer state construction modified methodology found significantly accurate conventional methodology suited applications unstructured construction environments results case study confirm use structural responses feasible measuring progress construction activities elsevier rights reserved
first used treat efficacy safety since changed classical treatment indications hepatic presents spectrum clinical conditions varying simple asymptomatic lesions lethal complications congenital vascular tumors lead syndrome like pure malformations cause heart failure diffuse type present hypothyroidism respiratory problems hepatic failure associated diffuse liver spectrum approaches management varying waiting liver transplant age prominent change hepatic treatment algorithm suggestion early treatment day plus day patients protocol effective strategy type hepatic approximately one third patients abdominal compartment syndrome era treatment required liver transplant new treatment transplant many patients
article presents summary development computer code code based multi group neutron diffusion theory kinetics equations include delayed neutron precursors space discretization process applied using nodal finite elements method known method used time discretization high performance computing methodology implemented solve resulting linear algebraic system right right numerical solution large algebraic systems representing full nuclear reactor cores achieved acceleration technique based open source linear algebra library implementation allows gpu thousands arithmetic operations parallel processing acceleration demonstrated use different nuclear fuel arrays resulting extremely large matrices getting speedup ratio finally acceleration capabilities hpc implementation presented simulation power transient actual water reactor core elsevier ltd rights reserved
highest level mathematics seen isolated creative activity produce proof review acceptance research peers mathematics now remarkable point new technology extending power limits individuals together diverse experts solve problems symbolic computation huge routine calculations computers using programs designed verify hardware check just long complicated human social machines new paradigm identified viewing combination people computers single problem solving entity paper outlines research agenda new vision mathematics social machine combination people computers create apply mathematics places context verification research computational logic work computer proof
study investigated effect offer non ambivalent intimate partner violence ipv participants exposed ipv critical ipv offered ambivalent ipv results showed positive effects anti ipv positive negative effects ambivalent participants beliefs violent relationship findings suggest context ipv considered evaluating impact media depicting ipv
many types dependencies software requirements contributions dependencies make help break business dependencies modeled framework however current approaches requirements seldom take dependencies consideration difficult stakeholders prioritize requirements considering preferences dependencies requirements make requirement prioritization practical method called proposed following advantages prioritization evaluation attributes tree constructed make ranking criteria selection easier employed calculate subjective requirements prioritization according stakeholder preferences reduces difficulty evaluating prioritization algorithm based weighted proposed analyze dependencies requirements allowing objective dependencies automatically transformed partial order relations integrated requirements prioritization method developed stakeholders subjective preferences objective requirements dependencies make process prioritization reasonable applicable controlled experiment performed validate effectiveness based comparisons case based ranking analytical hierarchy process evolve results demonstrate less time consuming effective alternative approaches simulation experiment demonstrates taking requirement dependencies consideration improve accuracy final prioritization sequence elsevier inc rights reserved
optical frequency domain use polarization maintaining fiber pmf capable distinguishing strain temperature critical successful field applications structural health monitoring shm smart material location dependent measurement sensitivities along pmf compensated cross auto correlations measurements spectra form distributed parameter matrix simultaneous temperature strain measurement accuracy strain degrees achieved spatial resolution range
international meeting enzymology molecular biology carbonyl metabolism germany july covered aspects nad dependent involved general metabolism physiological carbonyl compounds starting years ago enzyme purification structure elucidation enzyme kinetics carbonyl society members meanwhile established internationally recognized enzyme systems now consider aspects enzyme genomics enzyme evolution along roles diseases international meeting included lectures international speakers world
east west divide contraceptive use patterns identified across europe western european countries characterized widespread use modern contraception central eastern european countries characterized high prevalence withdrawal rhythm method abortion building ready willing able framework study aims gain insight micro macro level socioeconomic cultural technological determinants underlying contraceptive use data generations gender survey covering four western seven central eastern european countries used multinomial multilevel analyses performed results reveal individuals delay likely use contraceptive method whereas holding traditional values lower socioeconomic status associated higher likelihood using traditional methods regional reproductive rights gender equality interact complex ways associations minimum results underline complexity processes underlying persistent difference contraceptive use across europe
transgenic male sterile line cotton generated ectopic expression gene arabidopsis thaliana via agrobacterium mediated transformation bacterium plasmid carrying coding sequence together gus reporter gene former driven promoter male gene arabidopsis latter control promoter twenty seven putative transgenic plants obtained showed gus activity positive signals genes pcr analysis also showed male extent confirmed southern blotting one copy gene integrated genome plants expressed male higher degree northern blotting assay also demonstrated stably transcribed genome transgenic plants generation male sterile plants usually display lower plant height shortened without pollen grains pollen grains unusual leaves deeper multi lobes microscope observations processes pollen mother cells showed abortion pollen grains mainly resulted abnormalities direct degeneration chromosomes multi polar chromosomes study indicates method developing novel cotton male sterile materials potential application agriculture engineering male important crops
background one important transitions continuum care children discharge home optimal discharge communication healthcare providers caregivers parents present emergency department children understood lack policies considerable variation practice regarding discharge communication pediatric eds pose quality safety risk children parents methods aim mixed methods study better understand process structure discharge communication pediatric context contribute design development discharge communication interventions use surveys administrative data real time video observation characterize discharge communication six common illness presentations pediatric asthma abdominal pain fever diarrhea vomiting minor head injury participants recruited one two urban pediatric eds canada video recordings analyzed using observer use logistic regression identify potential demographic visit characteristic multivariate logistic regression examine association verbal non verbal behaviours parent recall comprehension discussion video recording discharge communication provide opportunity capture important data sequence non verbal behaviours influence communication process given importance better characterizing discharge communication identify potential barriers anticipate findings study contribute development effective discharge communication policies interventions
cancer currently treated combination therapies including chemotherapy believed suppress immune system combination immunotherapy chemotherapy correlates improved survival needs careful planning order achieve synergistic effect study demonstrated doxorubicin treatment cells resulted increased expression increased cell activation presence effect inhibited addition blocking antibody furthermore doxorubicin resulted decreased expression anti inflammatory cytokines tnf alpha finally cells urinary bladder cancer patients treated containing doxorubicin displayed increased expression conclude doxorubicin induces expression cells hence enhances antigen presenting ability vitro finding verified patients development tailored time dose schedules increase effectiveness combining chemotherapy immunotherapy published elsevier inc
currently centers disease control prevention recommends persons years get tested human immunodeficiency virus hiv least lifetime persons hiv risk factors get tested frequently limited research examining factors associated never testing hiv among non hispanic black men united states purpose study examine prevalence never testing hiv reasons never testing hiv correlates never testing hiv analyzed national survey family growth data restricted analyses male respondents aged years self identified non hispanic black logistic regression models estimated adjusted prevalence ratios assessing association socio demographic behavioral factors never testing hiv estimated non hispanic black males aged years never tested hiv non hispanic black men aged years years visit doctor healthcare provider report sexual risk behaviors past months likely never test hiv compared respective counterparts continued expansion hiv testing initiatives prevention programs focus non hispanic black men critical addressing hiv related health disparities public health burden hiv population
paper review previous research paper presenting scheme quantum key distribution performs authentication using quantum means authentication mechanism protocol runs along checking approach upgrade security properties especially man middle attack propose revised enhanced scheme probability detecting improved use tool model analyze security quantum system emphasize extent contribution particularly focus two security features capability participants protocol detect attempt valid knowledge gained shared key minimized john wiley sons ltd
purpose development implementation program pharmacy residents described summary university north medical center met call increased efforts area pharmacy leadership training design implementation evaluation leadership program purpose program develop leaders serve others improve communities advance profession program designed foster self awareness social awareness provide individualized leadership experiences enrich components integration leadership development opportunities create role models leadership team residents implemented program integrating program components existing pharmacy infrastructure program includes required flexible components allow residents set achieve determined leadership development goals overall residents satisfied program perceive first years since implementation certification initiative program facilitators improved feasibility participant engagement sustainability program future directions include effectiveness evaluation scale institutions conclusion need pharmacy leadership met designing implementing evaluating program first years program feasible sustainable valued program participants
background pathophysiology poorly understood though various studies report gut microbiota dysbiosis infants aimed test hypothesis related dysbiosis associated visceral hypersensitivity triggered altered luminal milieu methods fecal samples seven seven non infants studied fecal supernatants mice specimen visceral sensitivity subsequently assessed animals recording abdominal muscle response colorectal serine cysteine protease activities assessed specific substrates infant fecal microbiota composition analyzed dna extraction rrna gene key results infants triggered higher activity non infants response largest volumes overall assessed area curve across volumes infant time strongly correlated mouse activity microbiota richness phylogenetic diversity increased group without showing prominent microbial composition alterations increased group abundance positively correlated visceral sensitivity differences found protease activities conclusions inferences luminal contents infants trigger visceral hypersensitivity explain excessive behavior infants additional studies required determine nature compounds involved mechanism action potential implications intestinal microbiota generation
paper presents empirical study based set measures evaluate usability mobile applications running different mobile operating systems including android ios aim evaluate empirically framework developed use software quality standard iso mobile environments especially usability characteristic users participated experiment used iso iso standards objective measures working two widely used mobile applications google apps google maps questionnaire used collect measures assessing users level satisfaction using two mobile applications analyzing results highlighted set mobile usability issues related hardware software need taken account designers developers order improve usability mobile applications
found irreversible post translational modification considered biomarker oxidative stress plays major role various biological processes also associated diseases alzheimers disease diabetes parkinsons disease however since experimental technologies costly time consuming detect sites proteins accurate computational method predicting sites urgent issue useful drug development study novel computational tool termed site developed predict protein sites incorporating sequence coupled information general pseudo amino acid composition balancing effect skewed training dataset different error costs method constructing predictor using support vector machine classifier site predictor achieves average auc area curve score predicting sites respectively experimental results along auc found average complete runs fold cross validation results indicate significantly better performance existing predictors published elsevier inc rights reserved
multiple object tracking fundamental step many computer vision applications however detecting tracking objects complex background still challenging task paper proposes approach combines improved gaussian mixture modeling multiple particle filters automatic multiple targets detecting tracking make improvement phase model updating using expectation maximization algorithm recent frames weight parameters gaussian distributions tracking stage integrate multiple features targets including color edge depth improve performance object tracking comparing various particle filter approaches experimental results show approach track multiple targets complex backgrounds automatically accurately
although recent laboratory tests showing promising progresses materials production technologies photovoltaic devices commercial modules show analogous impressive improvements therefore diagnostic approach able check current state health already installed systems trend ageing assumes strategic importance scenario introduce based diagnostics able provide detailed clear information thanks computer aided investigation much deeper today available infrared analysis proposed approach allows numerical qualitative evaluation cell device part framework introduces methodology based two main analyses first one cell analysis studies single cell second one cluster analysis focuses attention groups cells framework also characterized preprocessing region interest extracted infrared image order focus successive processing analyses area part platform results shows cloud platform implementing workflow automatically generates comprehensive detailed report discusses also several significant cases study
qualitative study examined foster parents perceptions initial transition period order better understand family formation process occurs new placement home sampling method used recruit ten foster parents participate constant comparative analysis interview transcripts guided grounded theory approaches yielded model foster family transition process identified three main tasks establishing trust sense belonging establishing family homeostasis working external stakeholders responsive trauma sensitive care realistic expectations parenting skills access resources facilitated foster family movement transition process foster families shared many tasks family forms adding new member unique aspects foster family context identified foster families often form incomplete knowledge new family members medical trauma history social service system unlike family types primary objective foster family formation study findings implications foster parent training support transition new placement value including foster parents perspectives research
extract obtained green confirmed fourier transform infrared spectrometry ftir nuclear magnetic resonance nmr percentage sulfate groups calculated elemental quantitative analysis twice dry algae dietary effect immunology growth evaluated fish fed commercial diet negative control group diet supplemented three levels feed additionally positive control yeast saccharomyces cerevisiae feed included trial period days days treatment days suspended treatment hemoglobin red blood cell count white blood cell count total serum protein albumin globulin activity measured days treatment day increased fish diets containing increase count observed day fish diets containing maintained days dietary suspension significant difference growth performance among fish diets tested first report increment immune response dietary supplementation results demonstrate potential activity least two mechanisms immune response time activity sustained organism suspension supplementation
purpose study examine incidence mechanisms acute injuries sport scientific studies injury characteristics yet conducted traditional sport game study conducted prospectively course months total sport specific exposure players reported injuries representing overall injury rate injuries exposure injuries classified injuries majority injuries located knee followed hip ankle injuries resulted longest impairment sports participation common types injury distortions muscle strains wrong insufficient equipment commonly mentioned causes injury data indicate injury risk rather high however sport considered high risk sport injuries slight prevent players training competition injury prevention strategies include development specific protective equipment focus knee joint
construction industry influences environment great deal using different resources efficient use resources important sustainability considerations heavy consumption energy one reasons causing adverse impacts built environment interest sustainable construction growing worldwide green building systems used projects green buildings different countries systems similar approaches build highlight requirements related energy consumption significant emphasis one recognized green building certification systems leed addresses energy optimization green power site renewable energy much detail maximum credit points achieved energy atmosphere category leed however use leed countries difficult local conditions practices influential study aims review practices energy atmosphere category leed new construction european countries analysis practices selected countries made based credit performances display variations depending local conditions expected practitioners countries benefit credit patterns providing improved insights site real applications authors published elsevier ltd
indian white flat prepared largely consumed economically poor sections country present study efforts made optimise measure index different green gram black gram soybean seed added proportion ranging addition received highest sensory score selected analysis determined vitro enzymatic method control showed whereas addition significantly lowered soft low
evidence shows increased risk psychological distress mental health problems populations despite often display ability continue function recover live meaningful productive lives parents mental health coping style significant mental health wellbeing children aim study explore coping mechanisms utilised care children twenty seven mothers two professional aid workers contexts turkey participated interviews focus groups data analysed using thematic analysis data structured three themes adaptation new norm acceptance reaching support problem solving gaining support keeping mentally strong using pain motivate parent number themes associated coping pre identified themes translated strategies improve culturally appropriate psychosocial interventions settings
type lead compositions synthesized citrate gel method structural magnetic properties resultant particles investigated ray diffraction xrd transmission electron microscope tem sample vector network analyzer magnetic properties saturation magnetization calculated hysteresis loops microwave absorption properties polymer composites prepared different ratios investigated frequency range ghz composite powder lead possesses good microwave absorption properties minimum reflection loss composite powder reaches thickness composite powder composite content shown minimum reflection loss bandwidth extended frequency range absorber thickness prepared composites utilized suppression electromagnetic interference reduction radar signatures stealth technology
background automatic analysis facial expressions evolving field finds several clinical applications one applications study facial parkinsons disease major motor sign neurodegenerative illness facial consists reduction loss facial movements emotional facial expressions called new method work propose automatic method studying facial expressions patients relying video based methods patients healthy control subjects asked show basic facial expressions upon request clinician visual cue screen existing face tracker euclidean distance facial model neutral baseline computed order quantify changes facial tasks moreover automatic facial expressions recognition algorithm trained order study expressions differed standard expressions results results show control subjects reported average higher distances patients along tasks comparison existing methods confirms control subjects show larger movements posed facial expressions moreover results demonstrate anger two impaired expressions patients conclusions video based systems important techniques analyzing facial expressions also rehabilitation particular speech therapy patients get definite advantage real time feedback proper facial expressions movements perform elsevier rights reserved
advancements software allow use embedded systems implementation control laws work microcontroller exploited order implement robust fixed low order controller electronic system parametric uncertainty model employed describe system behavior controller objective guarantee time response specifications presence model uncertainties controller design expressed min max non convex optimization problem taking account desired closed loop performances uncertainties accordingly aim obtaining optimal solution optimal control law application global optimization method recommended work exploited global optimization method generalized geometric programming implementation proportional integral controller proportional integral derivative controller fixed low order controller shows efficiency latter one
advancement micro continuously providing possibilities novel biochemical sensors however variations transducer type cause different sensing results due differences mechanisms analyzing interactions work focused comparative analysis static non static assays molecular interactions using chip integrated extended gate field effect transistor static sensing interface mounted resonator non static sensing interface analysis surface assembly antigen antibody interaction using two types biochemical sensors presented consistent complementary sets information meanwhile due difference operating mechanisms variations detection efficiency kinetics thermodynamics observed results highlighted critical dependence signal detection biochemical sensors operating mechanisms provided valuable guidance static non static assays elsevier rights reserved
recent advent ambient intelligence enabled parallel technological advancements sensing context recognition embedded systems communications paper focuses communication issues embedded systems particularly latency quality service qos metric multi communications standard examine viability communications embedded systems ami environments applications worldwide radio license free technology enables creation low power multi networks multiple devices sets procedure establish point point point links multi communications hence nodes interconnected form wireless networks paper presents research multi latency conducted using custom built test platform moreover empirical model derived calculate latency asynchronous links links always active mode designers ambient intelligent devices networks take advantage model estimation delay multi networks presented paper
theoretical frameworks regarding role life stress bipolar disorders incorporate possibility changing relationship psychosocial context episode initiation across course disorder hypothesis longitudinal course recurrent affective disorders relationship major life stressors episode initiation declines post present study aimed test extension hypothesis examining effect early life adversity relationship proximal life events prospectively assessed mood episodes data bipolar participants female caucasian mean age years years collected part longitudinal investigation bipolar spectrum project bipolar disorder participants completed self report measure early adversity baseline interview assessed mood episodes life events regular month follow ups results indicate early childhood adversity sensitized bipolar participants effects recent stressors depressive episodes episodes within particularly case minor negative events current study extends prior research examining model using rigorous assessment life stressors mood episode occurrence clinicians assess experiences early adversity individuals impact reactivity developing depressive episodes response future stressors
sets common features essential assets fulfilling specific needs software product line methodology requirements reuse extraction software features software requirement specifications viable practitioners access software due organisational privacy always kept easily available public alternatives researchers use publicly available software descriptions product online software descriptions identify potential software features initiate process aim paper propose semi automated approach known feature extraction reuse natural language requirements extract represent software features software reviews absence way initiate process composed four stages depend keyword occurrences several combinations experiment conducted reflect software features reside within online software reviews extracted utilising techniques information retrieval area way demonstrate feature phase semi automated approach group extracted features conducted assistance modified word overlap algorithm evaluation proposed extraction approach evaluated experiments truth data set created manually performance results obtained feature extraction phase indicates proposed approach performed related works terms recall precision measure elsevier rights reserved
objective nation wide study adult aimed provide characteristics medical utilization states survival rates newly diagnosed patients primary malignant spine tumors methods data patients primary spine tumors selected korean health insurance review assessment service database data included age sex health insurance type morbidities medical cost hospital stay duration hospital stay duration medical costs per person occurring one year used addition survival rates patients primary malignant spine tumors evaluated results incidence rate primary spine tumor increased age year diagnosis average annual medical costs ranged tumors spinal cord tumor primary spine tumor spinal tumors primary malignant spine tumor overall survival rates primary malignant spine tumor months respectively cox regression model results showed male sex medicare insurance significantly positive factors affecting survival diagnosis primary malignant spine tumor conclusion study provides detailed view characteristics medical utilization states survival rates patients newly diagnosed primary spine tumors korea
paper develop optimal sleep wake scheduling algorithms smart mobile devices powered batteries capable harvesting energy environment using novel combination two lyapunov optimization approach weight perturbation first design optimal sleep wake scheduling algorithm require knowledge energy process prove able achieve system performance within epsilon optimal explicitly compute required battery size epsilon extend results incorporate system information algorithm design specifically develop information aided algorithm introducing novel drift idea lyapunov optimization show able achieve epsilon close optimal utility performance ensures required traffic buffer energy storage size log epsilon high probability
paper proposes novel approach building natural language interface relational database using agent information extraction object relational mapping framework help users queries guiding user interaction play important role named entities extraction order map natural language queries database queries framework framework impedance mismatch object oriented paradigms relational databases concepts differ concepts thus reduces complexity generating sql statements also utilizing framework entities mapped real world objects bring step closer user addition framework simplify interaction developed system allows user interact objects directly natural language navigation rather using sql statements direct interaction tends easier acceptable humans technically sql knowledge system also offers friendly interactive user interface order refine query generated automatically system evaluated group participants combination qualitative quantitative measures experimental results show good performance prototype excellent users satisfaction
good behavior game classroom management strategy uses group oriented contingency promote prosocial behavior decrease problem behavior meta analysis synthesized single case research across studies representing students pre grade effect size across phase contrasts confidence interval indicating substantial reduction problem behavior increase prosocial behavior participating students five potential moderators examined emotional behavioral disorder risk status reinforcement frequency target behaviors format grade level findings suggest effective reducing disruptive task behaviors students risk benefit intervention implications research practice discussed
protocol introduces detect differentiated cells simple whole mount enzymatic activity assay identifying differentiated tissues staining beta dehydrogenase delta beta activity positive cells critical monitoring morphology differentiation tissues mammals respectively zebrafish model optical transparency tissue permeability developing embryos larvae allow whole mount staining beta activity staining protocol performed transgenic fluorescent reporter lines developing endothelial cells enables detection tissue addition kidney neighboring vasculature combination immunohistochemistry confocal microscopy visualize assay vascular microenvironment tissues beta activity assay essential studying cell biology zebrafish gland date suitable antibody available labeling zebrafish cells furthermore assay rapid simple thus providing powerful tool mutant screens targeting adrenal genetic disorders determining disruption effects chemicals pharmaceutical toxicological studies
blue light receptor plants shows dependent kinase activation excited light oxygen voltage sensing domain primarily responsible activation kinase domain however molecular mechanism conformational changes transmitted kinase domain remains unclear investigated induced structural changes minimum functional fragment arabidopsis composed kinase domain linker connecting two domains using small angle ray scattering fragment existed dimer displayed changes reflected dark irradiation dark molecular shape reconstructed profiles appeared two shaped lobes arrangement long wide thick molecular shape became slightly dark fitting crystal structure dimer homology model kinase domain inferred shapes dependent change interpreted shift kinase domain relative dimer addition found lysine functionally important residue terminal region plays critical role transmitting structural changes kinase domain interface domains critical signaling suitably changing structure activate kinase response conformational changes
background many studies indicated immune dysfunction involved schizophrenia aggression study aimed investigate correlation high sensitivity reactive protein interleukin clinical characteristics especially aggression explore potential role plasma biomarkers schizophrenia methods forty one patients schizophrenia forty healthy individuals enrolled psychopathological severity aggression assessed using positive negative syndrome scale modified overt aggression scale plasma concentrations assessed enzyme linked immunosorbent assay elisa results higher levels lower levels higher ratio observed plasma patients schizophrenia compared healthy controls roc receiver operating characteristic curve analysis revealed ratio predictive value sensitivity specificity applicable biomarker distinguish patients schizophrenia control group alone predictive value respectively found positive correlations total score verbal aggression score total score conclusions results suggest possible function pathogenesis schizophrenia possible value potential peripheral biomarker schizophrenia finding also suggests relationship ratio aggression patients schizophrenia elsevier rights reserved
identifying dependencies hold relational databases essential produce good databases designs particular functional dependencies used obtain relation schemes satisfy normal form property considered satisfactory applications known class sets functional dependencies exact model learning queries also dependencies class consequent restricted dependencies shown model paper present algorithm class contains sets functional dependencies restrictions imposed antecedents dependencies also show product algorithm non trivial quasi formulas closely related class just mentioned
number resistive switching memories exhibit activation based dynamical behavior makes suitable programmable analog filtering applications boundary condition model accounts tunable activation thresholds boundary states quantitatively accurate description kinds investigation circuit applications paper introduces generalized boundary condition model preserving features model allowing hoc tuning activation based dynamics enables appropriate modulation conditions operate storage elements data processors simple circuit implementation novel model presented time efficient simulations confirming improvement modeling accuracy model shown proof concept suitability model exploration full potential circuits programmable analog filters paper adopts model fundamental synaptic rules governing mechanisms learning neural systems gain insight key issues design couple filters copyright john wiley sons ltd
premature failure expansion joints concern bridge owners opening traffic suspension bridge experienced frequent damage expansion joints problem remained even replacement new expansion joints installation viscous girder end paper aims clarify failure mechanism expansion joints based field test results field tests consist three scenarios static test influence line test pass test tests aimed investigate behavior expansion joints global local scales static influence line tests found strain response expansion joint affected girder deformation reflects effect global behavior bridge expansion joints pass test result shows direct impact heavy induce high strain expansion joints indicates expansion joints affected vehicle loading local scale results accordance premature failures observed expansion joints bridge american society civil engineers
international estimates incidence non accidental children admitted burn centres vary hardly data dutch figures exist aim study evaluate incidence treatment outcome due suspected child abuse paediatric described process care outcome including accuracy screening tool examined child burn treatment characteristics related child abuse neglect retrospective study conducted children aged years primary admission burn injuries burn centre period data patient injury treatment characteristics collected using dutch burn repository addition medical records reviewed paediatric admissions suspected child abuse neglect present children screening questionnaires completed questionnaires completed one positive signs significant independent predictors suspected child abuse genital area low socio economic status incidence suspected child abuse indicating generation additional support population comparable studies similar design countries elsevier ltd rights reserved
magnetorheological fluids new type smart material whose performance evaluated considering three important factors stability viscosity shear yield stress fluids study produce fine dispersed fluids appropriate components preparation techniques adopted surface treatment method developed involving different property tests fluids conducted results demonstrated proposed preparation method sedimentation fluids viscosity fluids varied temperature shear rate liquid paraffin reduce viscosity fluids gradually acid addition variations shear yield stress magnetic induction intensity volume fraction determined accurately describe shear yield stress fluids limited chain model considers spatial distribution carbonyl iron particles model size magnetic saturation phenomenon proposed comparison theoretical experimental values obtained study indicates order limited chain model effectively calculate shear stress fluids american society civil engineers
protein microarrays represent powerful technology potential serve tools detection broad range analytes numerous applications diagnostics drug development food safety environmental monitoring key features analytical protein microarrays include high throughput relatively low costs due minimal reagent consumption fast kinetics hence measurements possibility functional integration far especially fundamental studies molecular cell biology conducted using protein microarrays potential clinical notably point care applications yet fully utilized question arises features implemented improvements made order fully exploit technology past identified various obstacles overcome order promote protein microarray technology diagnostic field issues need significant improvement make technology attractive diagnostic market instance low sensitivity deficiency reproducibility inadequate analysis time lack high quality antibodies validated reagents lack automation portable instruments cost instruments necessary chip production read scope paper hand review approaches solve problems
analyze quantitatively interface core structural plastic composites surface relationship microstructure composite surface macroscopic impact performance investigated effect layer interface impact strength core studied scanning electron microscope sem images computer image processing technique fractal theory fractal dimensions core calculated relationship measured impact strength fractal dimensions core fracture surface discussed results showed fractal dimensions interface fracture surface within range respectively coefficients higher therefore strong linear correlation indicated fractal characterization interface impact fracture surface possible also proved interface analyzed quantitatively depending feature parameters fractal dimension relationship fractal dimension measured impact strength linear bigger fractal dimension surface bigger impact strength stronger interfacial bond thus using fractal dimensions surface morphology core structural described provide new approach investigate inherent rules fractal characteristics impact strength core structure
aim study characterize determine inter exchange beta plasmids isolated humans pigs environment plasmids isolated total antimicrobial resistant salmonella isolates representing human clinical cases pigs farm environment characterized typing restriction digestion inter conjugation presence beta enzyme encoding gene southern hybridization based typing majority plasmids belonged gamma inc group potential inter plasmid transfer confirmed pcr detection genes plasmids isolated trans plasmids salmonella isolated cohort pigs environment single human clinical isolate identical plasmids based digestion multiple restriction enzymes southern blotting demonstrated likely horizontal inter exchange plasmid encoding beta resistance among salmonella isolated pigs farm environment clinical human cases study provides valuable information role farm environment extension livestock farm environments potential reservoir resistant bacterial strains potentially transmit resistance determinants livestock case humans possibly hosts horizontal exchange plasmids elsevier rights reserved
conditions chronic rhinitis urticaria angioedema asthma frequently seen clinics hospitals core group medications often used treat conditions knowing indications optimal dosing side effect profile medications improve outcomes chronic rhinitis due various causes one common reasons primary care physician visits knowing indications use forms administration side effect profiles medications help improve patient outcomes common conditions article focuses medications used treat conditions
cloud computing one increasing technology connected grid computing utility computing distributed computing todays world securing data plays vital role computing environment data privacy data security popular fields like government industry business future development inter related hardware software hence paper analyses data security solutions cloud computing
recent years deep neural networks demonstrated significant business impact large scale analysis classification tasks speech recognition visual object detection pattern extraction etc training large however universally considered time consuming computationally intensive task demands scale computational resources recruited many days propose concept resistive processing unit devices potentially accelerate training orders magnitude using much less power proposed device store update weight values locally thus minimizing data movement training allowing fully exploit locality parallelism training algorithm evaluate effect various device features non system parameters performance order derive device system level specifications implementation accelerator chip training realistic cmos compatible technology large billion weights massively parallel architecture achieve acceleration factors compared state art providing power efficiency problems currently require days training size cluster thousands machines addressed within hours single accelerator system consisting cluster able tackle big data problems parameters impossible address today like example natural speech recognition translation world languages real time analytics large streams business scientific data integration analysis multimodal sensory data flows massive number iot internet things sensors
values gender roles importance reputation maintaining ones place society maintaining respect groups one belongs sense provides template organizing social interactions hence functional even among people societies report test prediction influences judgment attention activated two experiments using culture situated cognition perspective predicted activating one aspect activate aspects even among individuals much endorse values tested predictions among european americans group typically associated values study participants randomly assigned experimental control groups differed one way experimental group read statements values first step control group participants judged figure pairs judging male study made decisions judging whether letter string formed correctly word study study experimental group participants likely choose visually figure male study experimental group participants accurate letter string formed word word relevant word differ control group word irrelevant happy participants studies just neutral point endorsement values individual differences values endorsement moderate effects activating though often described located space find clear effects letter strings located computer screen findings suggest new way consider functions even societies highly endorsed value
smart environments integrated multiple heterogeneous devices perform operations intelligent manner considering context actions behaviors users major objective enable environment provide ease comfort users reliance systems demands consistent behavior versatility devices user behavior communication complicate modeling verification reliable behavior many available modeling verification techniques formal methods appear promising due large variety implementation scenarios support conditional behavior processing concept applicable diverse areas calls focused research result number modeling verification techniques made available designers paper explores puts perspective modeling verification techniques based extended literature survey techniques mainly focus specific aspects overlapping scenarios user interaction devices interaction control context awareness etc interest researchers based specialized competencies techniques categorized basis various factors considered modeling verification later analyzed results show surveyed technique maintains holistic perspective technique used modeling verification specific aspects results help designers select appropriate modeling verification techniques given requirements stress effort modeling verification research
paper presents mathematical programming model optimal design water networks agriculture proposed model based new includes configurations terms use reuse regeneration water field constituted number model also includes allocation pipelines pumps storage tanks different irrigation periods objective function consists maximizing annual profit formed economic owing crop costs fresh water fertilizer storage tanks treatment units pumping proposed multi period optimization problem formulated mixed integer non linear programming formulation applied case study demonstrate economic environmental social benefits obtained elsevier ltd rights reserved
psychotherapeutic genetic counseling increasingly relevant practice description paper aim demonstrate psychotherapeutic genetic counseling achieved using psychological theories guide ones approach working clients describe two illustrative examples fuzzy trace theory cognitive behavior theory apply two challenging cases theories partially derived evidence beneficial client outcomes using psychotherapeutic approach patient care settings aim demonstrate two specific theories inform psychotherapeutic genetic counseling practice use examples take psychological theory effectively apply genetic counseling
flash flood forecasting catchment systems one challenges especially arid basins study attempted estimate relationship rainfall runoff also provide flash flood hazard basins based hydrological characteristics using geographic information system gis morphometric characteristics drainage basins provide means describing hydrological behavior basin study examined morphometric parameters emphasis implication hydrologic processes integration analysis morphometric parameters gis techniques data study obtained data digital elevation model resolution topographic map geological maps subject field confirmation morphometric parameters measured calculated produce nine effective parameters evaluation flash flood hazard degree study area based nine effective morphometric parameters directly influence hydrologic behavior time concentration flash flood hazard basin identified classified three groups high medium low hazard degree present work proved features drainage basin contribute possibility flash flood hazard evaluation particular drainage area study provides details flash flood prone mitigation measures study also helps plan rainwater harvesting watershed management flash flood alert zones based two historical data events rainfall corresponding maximum flow rate morphometric parameters stormwater management design aid software generate basin result model applied basin rainfall event total duration station nearby study area probability return period around years produces discharge volume delta outlet basin rainfall recharge
purpose evaluate application whole genome sequencing determining inter foci clonal relationship thyroid carcinoma methods reviewing patient profiles cancer foci germline control samples patients analyzed single nucleotide variations copy number variation structural variation mutational signature examined results rate shown larger primary tumor diameter higher rate lymph node metastasis less number accompanying non cancerous lesions single one gender groups cancer foci foci identified clonal independent model rest foci clonal derived model according spectrum non mutations provided compelling evidence genome wide level classification specific mutational signatures also identified conclusions impressive tool clonal relationship determination providing view genome wide somatic mutations substantial sequencing data provided additional information help studying mechanism carcinogenesis elsevier rights reserved
exploring relationship genetic factors outcome following brain injury received increased attention recent years however studies evaluated influence genes specific sequelae purpose study determine allele apolipoprotein apoe gene influences symptom expression following sports related participants included athletes underwent neuropsychological testing including completion post symptom scale within months sustaining evaluated within week athletes provided samples analyzed determine make apoe genotype dependent variables included total symptom score four symptom clusters derived mann whitney tests showed higher scores reported athletes allele compared without total symptom score physical cognitive symptom clusters furthermore logistic regression showed allele independently predicted athletes reported physical cognitive symptoms following findings illustrate athletes report greater symptomatology post athletes suggesting genotype confer risk poorer post outcome
false working memories readily emerge using visual item recognition variant converging associates task two experiments manipulating study test modality extended prior working memory results demonstrating reliable false recognition effect false alarms related lures unrelated lures within seconds encoding either visual auditory modality however false memories nearly twice frequent study lists seen heard regardless test modality although study test modality mismatch generally consistent encoding specificity final experiment varied study test modality using hybrid short long term memory test replicated auditory advantage short term revealed reversal long term false memory effect greater auditory study test condition visual study test condition thus encoding conditions gave rise opposite modality advantage depending whether recognition tested short term long term memory conditions although demonstrating continuity associative processing across delay results indicate delay condition affects availability modality dependent features memory trace thus leading patterns short long term memory performance
today buildings energy consumption considerable amount whole therefore optimizing energy buildings leads noticeable decrease total energy consumption world energy efficient buildings developed carrying great research effort control procedures serve method help new buildings comply optimal system energy consumer thus meet nearly zero energy purpose paper present method controlling building temperature simultaneously reducing cost providing hybrid heating systems sufficient energy investigating room city day example methods model predictive control mpc economic optimization mpc consecutively mpc without economic optimization proportional integral derivative pid controller optimized genetic algorithm presence gas thermal source pid controller optimized presence electric thermal source pid controller optimized multi objective presence two gas electric thermal sources designed implemented research furthermore effect methods cost reduction temperature regulation inside room studied eventually specified using mpc method economical optimization highest influence cost reduction keeps temperature inside room predefined range method achieved cost saving compared mpc main targets study regulating inside temperature cost optimization according main targets study using mpc methods without economical optimization multi objective genetic algorithm effective elsevier rights reserved
global growth geosynthetics last decades substantially enhancing average per within domain geotextile geotextile class natural technical textile niche emerging technology though far behind man made counterpart growth effectiveness addressing host different geotechnical problems importantly eco gaining increasing acceptability worldwide major uses road construction low medium volume roads particular soil erosion control etc traditional quality woven fabrics plain used mentioned applications use conventional fabrics application specific function oriented deserves adoption conventional fabrics used flexible packaging road construction soil erosion control geotechnical construction context development potentially important strengthening rural roads river bank protection assumes significance realized woven whose property parameters functionally serving purpose paper outlines structured approach fabric engineering related tune different prime parameters design concerning rural road construction river bank protection along optimization standardization fabric comparative analysis different tests results property parameters developed samples
recent years rheumatic conditions gained increasing attention care aging patient population multiple diseases therefore rule exception owing high prevalence potential interaction coexisting diseases needs taken account treating patients chronic inflammatory conditions review address prevalent comorbidities patients rheumatic conditions impact important outcomes physical function quality life mortality
work electrical impedance spectroscopy applied alternative method origin determination supplement labeling according european legislation impedance measurements agreement data routine analyses allowed distinguish samples acquire information chemical physical properties conductivity ash content equivalent electrical circuits extracted sample validated means electrical simulation every electrical component associated specific characteristic concluded method developed permits rapid easy determination origin sample preparation procedure required used official control laboratories elsevier ltd rights reserved
corrosion caused hydrogen formation serious problems operations cost prevent problems high understanding sulfur cycle mechanism controlling sulfur cycle sediment biofilm essential solve problems review reaction mechanisms sulfur cycle sediment biofilm systems revealed using situ measurements molecular biological technologies summarized results indicated profile reaction process sulfur cycle sediment biofilm primarily affected substrate concentration change liquid phase various substrate sediment biofilm biological distribution shifting sulfate reduction bacteria oxidation bacteria across sediment biofilm response substrate change microenvironment sediment biofilm influence flow fluctuation profile sulfur cycle sediment biofilm field advantageous biological techniques analyses combined novel situ measurements new concept model related control technology sulfur cycle sediment biofilm promoted future studies
recent studies noted disproportionately adults histories childhood home compared adults without suffer adulthood psychological physical problems however findings based mostly research investigating adults foster care system building foundation study examined adults histories living another type childhood home placement called youth villages situation israeli society reserved youths come families added challenge immigrants single parent families parents struggle mental health problems substance abuse studys aim examine longer term adulthood impact lived youth villages health status making comparisons general population using sample matched age gender youth villages provided lists ages telephone questionnaires administered november december adult youth village compared matched sample general population drawn existing israeli nationwide data set conditional logistic regression used compare health status two groups youth village found experienced many adverse childhood events graduates foster care system however adjusting confounders health status two groups differ dramatically different finding compared studies foster care graduates suggests precursors home placement home placement always devastating experiences adulthood health future studies needed examine context process home placement including events preceding placement context assigning placement placement stability placement fit youths temperament preparation exit placement
background muscular common autosomal dominant muscular disorder caused contraction repeats complicated genotype phenotype correlation among different ethnic population remains controversial subject aimed refine correlation order provide new information genetic counseling methods cohort chinese families including affected individuals unaffected members investigated genetic analyses performed using probes pulsed field gel electrophoresis separation southern blotting grade clinical severity scale adopted clinical assessment genotype phenotype correlation established linear regression analyses results observed roughly correlation short fragment size age corrected clinical severity score symptomatic patients compared male patients significant higher proportion females asymptomatic carriers severe patients showed larger variation size short fragment high incidence asymptomatic minimally affected carriers found familial members conclusions although number repeats known one critical influences genotype phenotype correlation majority phenotypic spectrum still heterozygous contraction repeat female cases results suggest multi factors synergistically modulating phenotypic expression
facilitate motion control planar motors stationary circular coils paper real time model proposed predict force torque exerted magnet array force torque calculated lorentz force law essentially expressed calculation volume integral due symmetry circle force torque generated coil change circular coil around axis characteristic significantly utilized calculation volume integral integral real time model calculation independent position rotation angle moving magnet array calculation result numerical considered constants thus real time model paper computed quickly finally experiments carried provide verification proposed real time model computation time model digital signal processor system force torque predicted model consistent measurement data
given documented gender differences risk factors manifestations violence researchers advocated gender sensitive approaches violence risk assessment study compares male female forensic psychiatric patients array demographic clinical behavioral legal variables gain understanding prevalence different risk factors types violence population investigate reliability item utility historical clinical risk management examine whether individual items exhibit differential relationships tools summary risk rating across gender women carried diagnosis borderline personality disorder whereas antisocial personality disorder substance use problems extensive criminal histories often noted men clinical differences reflected distribution item subscale scores across gender reliability excellent especially women lack personal support increased odds deemed high risk women greater extent men discuss utility structured professional judgment tools women consider importance gender sensitive approach risk assessment
feasibility study performed order demonstrate benefits designing manufacturing customized foot means digital technologies reverse engineering generative design additive manufacturing aim work define complete design manufacturing process starting scanning human foot anatomy direct customized foot moreover first methodological study tries combine user friendly semi automatic modelling approach use low cost devices laser scanning printing processes finally result approach based digital technologies also compared achieved means conventional manual techniques
although still debated whether underlies migraine resolution recommended patients cardiovascular risk however relationship stroke incidence use unclear unknown whether acute chronic use drugs ischemic brain injury address issue investigated effect clinically relevant doses potent cerebral artery cerebral blood flow brain volumes expression genes involved cerebrovascular regulation report acute treatment rats mice reduce basal dropped upon treatment acute chronic month also affect changes volumes mice undergoing brain ischemia finally chronic reduced brain mrnas leaving unaffected significant transcript changes found data suggest impact cerebral hemodynamic evaluated propensity increase stroke risk ibro published elsevier ltd rights reserved
analysed extent ecological damage inter erosion sub catchment situated winter rainfall area south africa small stock farming main source income applied low cost measures bare sites inter erosion erosion soil surfaces applying geotextile constructing check dams reverse erosion compared vegetation cover accumulation penetration resistance soil check dams situation check dams untreated controls treated bare patches compared penetration resistance vegetation cover untreated controls two years implementation restoration measures resulted increased soil depth vegetation cover check dams increased vegetation cover treated bare patches calculated net present value restoration measures based financial benefit expect current economic governance conditions payment additional livestock current rates return livestock production carbon year period rehabilitation sort feasible private either current payment carbon increased magnitude restoration measures funded public private sector make viable copyright john wiley sons ltd
article presents instructional framework collaborative learning called aimed analysis level taxonomy mobile collaborative tool called supports aimed domain scope programming learning topic present programming courses engineering studies specification development explicitly driven pedagogical goals atomic actions simple items collaborative activities furthermore evaluated actual educational context respect students performance motivation students using obtained statistically significant higher grades students studying individual collaborative basis using addition measured statistically significant measures indicating students instructed motivated students instructed using addition evaluation results experiences reported exemplify several software engineering practices design educational system based knowledge target domain namely taxonomy evaluation users satisfaction mainly students motivation
paper methodology designing architecture processor array wide class image processing algorithms proposed concept spatially expanding sfg description enables handle problem merely one dimensional signal processing used constructing methodology problem interface critical real time processing also considered
examined effects light intensity metabolism antioxidant enzymes expression related genes determine optimal lighting conditions aquaculture animals dehydrogenase activity significantly lower animals exposed light intensities mol lactate dehydrogenase activity lactic acid content significantly higher compared animals dark exposed mol throughout experiment however ros contents light intensities mol peaked expression levels genes encoding catalase cat peroxidase sigma glutathione transferase glutathione transferase also began increase cat glutathione peroxidase activities significantly higher animals dark exposed mol ros content mol began decrease activity malondialdehyde mda content also gradually decreased followed increases ros mda later reach respective peaks gene expression levels heat shock protein cat began decrease later suggesting excessive accumulation ros caused oxidative damage tissues light intensity mol expression levels genes total antioxidant capacity activity peaked ros content significantly higher group later however gene expression levels cat reduced glutathione content began decrease indicating antioxidant system unable perform normal physiological functions long term stress adverse environmental factors results suggest light intensity controlled mol aquaculture maintain organisms normal physiological metabolism statement relevance disc economically important china demand growing high protein low fat harvested sources supply currently meet consumer demand recent years natural habitat declined result marine water pollution among others leading sharp decrease numbers wild thus development system farming protection wild focus current research light including photoperiod quality intensity one key environmental factors influencing growth culture survival aquatic organisms evolutionary time organisms evolved physiological behavioral mechanisms enable adapt diurnal fluctuations light chinese traditional aquaculture net usually used nature particular usually provides setting adult increase food intake rate facilitate growth promote gonadal development natural environment light intensity water area relatively stable suggesting key effect light intensity growth development found dark environment adversely affected daily aquaculture production also associated lower growth rate compared animals higher light intensities lower food conversion efficiency greater energy losses excretion physiological metabolism antioxidant defense systems therefore key indicators measuring suitability light intensity aquaculture production therefore examined effects light intensity metabolism antioxidant defense system expression related genes using light emitting diode led replace conventional fluorescent light source results study improve understanding physiological tolerance antioxidant defense characteristics different light intensities enable optimization environmental light conditions aquaculture published elsevier
background initiating tobacco use adolescence increases risk nicotine dependence continued smoking physician screening tobacco use increases odds physicians patients smoke however without appropriate follow physician screening tobacco use enough significantly increase cessation rates given critical phase development adolescence poses tobacco use evidence physician intervention improves adult cessation efforts sought examine physician tobacco use screening advice quit among adolescents years methods using data national survey drug use health examined prevalence correlates tobacco use screening adolescent respondents reported visiting physician within past year multivariable logistic regression analyses explored relationship tobacco use screening physician advice quit sub set sample reported physician advice quit controlling cigarette use substance use screening results adolescents visited physician within past year reported screened tobacco use adolescents screened physician predominantly female white late adolescence covered private health insurance screening tobacco use highly correlated physician advice quit smoking controlling sociodemographic characteristics cigarette use relationship attenuated remained significant screening alcohol added model hispanic adolescents significantly less likely receive physician advice quit multivariable models conclusions findings suggest missed opportunities youth tobacco use prevention cessation efforts clinical setting research needed better facilitate open dialogue tobacco use physicians adolescent patients
higher education support identification training needs industrial building information modelling bim curriculum development sustainability education fields civil engineering management paper proposes framework based four phase step step quality function deployment application curriculum planning quality management framework attempts respond requests collected professionals order integrate bim higher education curriculum china specific focus construction management programs american council construction education entropy method scale adapted revised cognitive process employed evaluate curriculum proposed framework successfully applied curriculum planning included two four main knowledge areas provided chinese guidelines construction cost flow construction two curriculum areas showed content focus knowledge program evaluation review technique planning construction optimization flow construction principles quantities construction consumption construction costs teaching quality management china higher education curriculum focus three aspects promote curriculum integration pedagogical design teaching resource material curriculum assessment research sheds light pedagogical shift similar context established guidelines respect reviewing curriculum planning knowledge system perspective order meet industrial demands operational level
objective incidence posttraumatic shunt dependent head trauma unknown present study authors assessed timing development relationship whether placement permanent shunt also cases categorized temporal profile delay admission evaluated association outcomes discharge methods authors retrospectively reviewed cases patients diagnosed throughout year period cases sequential scans obtained evaluated index determine earliest time ventricular dilation observed discharge outcomes assessed using outcome scale childhood head injury score results thirty nine percent patients developed low admission scale score predicted early presentation week majority patients presented ischemic stroke hemorrhage significantly associated patients undergoing intractable intracranial pressure developed patients tended present lower scores develop early patients developed requiring shunt placement conclusions presents early particularly performed however authors found patients developed shunt dependent
silicon glass devices widely used industry mems solar energy system reliability simplicity manufacturing process trend toward level chip scale package technology suitable method silicon glass bonded structure become necessary paper combined experimental computational approach undertaken investigate feasibility cutting sandwich structure glass silicon glass laser induced thermal crack propagation method semiconductor laser cutting system double laser beams simultaneously top bottom sandwich structure designed mathematical model describing physical process interaction laser consists two surface heating sources two volumetric heating sources established temperature stress distribution simulated using finite element method fem analysis software crack propagation process analyzed using integral method fem model stationary planar crack embedded integral values around crack front edge determined using fem verification experiment typical parameters conducted crack propagation profile fracture surface examined optical microscope explained stress distribution integral value elsevier ltd rights reserved
decision support systems enhance health monitoring iot scenarios early detection neurodevelopmental disorders children thus ambient intelligence support innovative application domains like motor cognitive impairments detection home environment paper describes design innovative cooperative system supports refinement process knowledge base expressed ontology ontology supports decision making process core web based smart system aimed enhance screening language disorders medical centers schools fostering identification developmental disorders years old age set child smart care services use ambient intelligent paradigm early attention motor impairments children often diagnosed treated health care entities
surface flow generated bubble technique proposed collect surface floating substances great importance handling oil layer formed large oil accidents due need protect systems rivers lakes motivation research broaden understanding oil flow stratified layer oil free surface laboratory experiments carried order investigate multi dimensional motion water oil due flow structure bubble induced convection stratified liquid investigated using particle imaging velocimetry measurements measurements confirmed paper flow structure strongly modulated gas flow rate bubble size velocity surface flow induced bubble vicinity oil water interface larger stronger inside oil layer moreover surface flow particularly rapidly generated vicinity oil water interface highest kinetic energy generated far distance inside bubble vicinity oil water interface observation confirms idea bubble indeed generate strong wide surface flow bubble generation system oil layer easily broken especially high void fraction small bubble size high gas flow rates experimental results compared numerical results earlier paper confirmed paper experimental results resemble numerical results reference thermally stratified liquid liquid flow pattern bubble induced convection also measured using thermo sensitive liquid crystal tracer particles color image processing combined measure temperature field results compared stratified cases elsevier inc rights reserved
objectives far fewer injury surveillance systems exist within community sport elite sport result epidemiological data sports injuries limited relevance community level sporting populations potential data community based injury surveillance systems provide better understanding community sports injuries study aimed describe incidence profile community level australian football injuries reported using based injury surveillance system design prospective epidemiological study methods sports five community level australian football recorded injury data two football seasons using based system online surveillance tool developed sports medicine australia sports injury tracker used data collection injury incidence profile match injury rate reported results injury data players recorded season one players season two significant variability injury incidence across however aggregated data consistent across football seasons average injuries per player per season match injuries per match exposure large proportion injuries occurred matches involved lower limb resulted contact conclusions data based system provided profile injuries consistent previous studies community level australian football moreover injury incidence consistent studies using similar personnel record data however injury incidence lower reported studies using player self report healthcare professionals underestimate true values sports medicine australia published elsevier ltd rights reserved
urbanization natural social process involving simultaneous changes land systems energy flow demographics economy understanding spatiotemporal pattern urbanization increasingly important policy formulation decision making natural resource management combination satellite remote sensing patch based models widely adopted characterize landscape changes various spatial temporal scales nevertheless validity type framework identifying long term changes especially subtle gradual land modifications seriously challenged paper integrate annual image time series continuous spatial indices non parametric trend analysis spatiotemporal study landscape dynamics metropolitan area harness local indicators spatial dependence modified mann test describe monotonic trends quantity spatial arrangement two important land use land cover types vegetation built areas results suggest declines vegetation increases built areas two prevalent types changes across region vegetation increases mostly occur new residential areas developed natural proportion vegetation declines built increases seen central southeast part extensive land conversion agricultural fields urban land use one important driver vegetation declines practice also contributes part vegetation loss increasingly heterogeneous landscape quantitative framework proposed study provides pathway effective landscape mapping change monitoring spatial statistical perspective
new design method multilayer composite glass absorbing thin film presented composite glass high microwave reflective factor good transparency visible light region useful vehicle stealth technology microwave protection large capacity microwave transmission system
objectives study aimed evaluate influence fungal infection antifungal treatment outcome patients walled pancreatic necrosis methods retrospective description fungal infections cohort consecutive patients undergoing endoscopic drainage treated tertiary referral center reviewed results fungal infection documented patients common isolates first positive culture candida albicans candida thirty nine patients treated first fungal finding significant difference mortality organ failure group treated adequate first fungal finding compared group treated treated hospital mortality patients concomitant found patients died opposed fungi necrosis conclusions study demonstrates high incidence associated high hospital mortality fungal infection thus emphasizing importance fungal infections
prospective studies infant siblings children diagnosed autism spectrum disorder asd provide unique opportunity characterize asd critical question remains unanswered whether children asd resemble children identified community including family history purpose study compare clinical characteristics children asd identified method per group drawn two canadian longitudinal research cohorts children ascertained prospective cohort less severely affected included larger proportion girls compared clinically referred sample results important implications conclusions drawn studies high risk clinically referred cohorts
paper presents new circuit realization capable simultaneously realizing three current mode first order filtering functions namely low pass high pass pass proposed circuit created using three programmable current amplifiers two passive components includes one resistor one capacitor filters independently gain pole frequency means factors filter tunable gains pole frequency ideally controllable external passive components theoretical results verified spice simulations using transistor model process parameters bipolar arrays
modified epoxy resin prepared effects content epoxy resin type mechanical thermal properties materials discussed results indicate tensile strength impact strength material increase maximum successively decrease increasing addition mass fraction tensile strength impact strength materials best significant differences mechanical thermal properties material different epoxy best results cured epoxy
study aimed characterizing fatty acid composition red blood cell children adolescents primary ascertain potential association serum lipid profile dietary factors purpose aged years recruited subjects showed low omega index acid epa acid dha compared males females trend toward lower levels total fatty acids saturated fatty acids ratio inverse relationship concentration serum cholesterol hdl triglycerides ratio found omega polyunsaturated fatty acids positively associated serum hdl levels inversely dietary cholesterol fiber intake positively associated ratio conclusion provide first experimental data phospholipid composition children showing sex differences overall low omega index
present study provides insight heterogeneous response river basins western explores linkages variability changing parameters results show region undergone overall similar fluctuations temperature precipitation patterns seem primary factor controlling changes dimensions cases changes suggest depletion ice cover similar increase ice mixed debris similar debris similar debris similar transitions possibly result ice melting however relative rate elevation nature conversion increase proportion debris led conversion clean debris covered debris covered debris covered size greatly influenced rate conversion dominated others regard small also experienced maximum shrinkage varying debris cover respond differently debris covered exhibit highest rates followed clean debris covered thus findings work clearly show climate change driven dimensional changes variations spatial distribution strong mutual control elsevier rights reserved
optimization design simulating electro mechanical property conductive elastic fabric built based loops structure extensions computer program give fabric equivalent resistance obtained solving circuit network equations simplify computational process order simplify calculation forces overlapped two used represent loop configurations theoretical analysis experimental investigations found resistance changing due segment transfer key factor sensitivity elastic fabric sensors makes resistance linear increasing strain increasing analysis experimental results show change resistance fabric sensor due contact resistance minor contribution sensitivity sensor large strain regime also fabric structure affect characteristics fabric sensor
paper presents ambient assisted living framework support care people dementia framework integrates various sensor modalities ambient wearable offline cloud based together sophisticated interdisciplinary methods including image audio semantic analysis fine grained atomic events object manipulation aggregated complex activities semantic fusion applications tailored monitoring dementia symptoms support clinicians drive effective timely interventions evaluate outcomes framework evaluated robustness reliability clinical value real world lab trials home elsevier rights reserved
sequence sequence scheme direct sequence spread spectrum signal acquisition using block sequence estimation proposed analyzed proposed scheme consists estimator work according sequence chip clock provides enhanced chip estimates threshold decision logic one chip error correction among first received chips also reliability check estimates additional decision logic probabilities estimator operations calculated results detection false alarm missing probabilities proposed scheme derived addition using signal flow graph average acquisition time calculated proposed scheme used easily implemented changing internal signal path generally used digital matched filter lot sampling data memories sampled sequence numerical results show rapid acquisition performance relatively good
background overexpression histone observed many cancers inhibition specific emerged new target cancer therapy found expression selectively reduced inhibitor salivary carcinoma cells show suppression potent antitumor effect cells methods histone using cell proliferation quantified cell cycle progression apoptosis autophagy measured flow cytometry immunoblotting results histone inhibited cell proliferation myc expression increased expression caused phase cell cycle arrest cells silencing increased sub population positive apoptotic cells cleaved levels silencing induced increase markers number acidic organelles levels decrease levels reduced activation erk knockdown resulted growth inhibition phase cell cycle arrest induced apoptosis autophagy cells conclusions study indicates inhibition become novel effective therapeutic approach treating
conditions dermatology cause severe cracking skin representing failure normal several substances affect stratum identified treatment scaling disorders prominent among alpha hydroxy acids elaborated new pharmaceutical product combines biomolecules glycerol ammonium lactate aim study evaluate physicochemical stability properties new skin care preparation
objective examine association depressive symptoms contraceptive method choice among adolescents initiating prescription contraception study design cross sectional study analyzes baseline data urban minority adolescent females ages years presenting prescription contraceptive initiation comprehensive free cost adolescent health center new york city participants met health care provider provided standard contraception counseling initiating contraception participant selected short long acting contraceptive month supply pill patch ring acetate injection short acting placement referral intrauterine device long acting assess independent association contraceptive method selection symptoms depression assessed center epidemiological studies depression scale results ten percent adolescent females selected iud bivariate analysis revealed elevated levels depressive symptoms likely select iud compared minimal symptoms mean score multivariate logistic regressions adolescent females increased odds selecting iud reported moderate severe depressive symptoms adjusted odds ratio confidence interval controlling ethnicity race education number lifetime partners conclusions inner city minority adolescents elevated symptoms depression present prescription contraceptive initiation likely select iud rather shorter acting methods recognizing adolescent females depressive symptoms providers approach effective contraception counseling elsevier inc rights reserved
incidence bradykinin induced angioedema considerably lower histamine induced forms however true clinicians knowledge condition bradykinin induced include hereditary angioedema hae acquired forms induced drugs antibody formation course disease drug induced forms affect almost exclusively head neck region thus important clear differentiation histamine induced angioedema connected allergy urticaria bradykinin induced angioedema essential selection specific treatment derivatives relevant effect bradykinin induced angioedema whereas blood derived esterase inhibitor bradykinin receptor antagonists represent effective therapeutic options acute prophylactic treatment
new method obtaining random boxes based discrete chaotic map presented proposed method uses discrete chaotic map based composition obtained boxes tested number criteria nonlinearity strict criterion output bits independence criterion input output distribution maximum expected linear probability results performance test show box presented paper good cryptographic properties advantage proposed method possibility achieve large key space makes suitable generation boxes larger values also method uses discrete chaotic map based composition finite space domain need discretization continuous values chaotic map process generation boxes affected approximations kind
fast growing populations development energy crisis raised critical requirements utilization clean solar energy effective methods capture convert solar energy now include photocatalytic degradation hydrogen production dye sensitized solar cells photocatalytic selective reaction organic compounds key factors utilization solar energy many photocatalysts exploited great achievements made possesses unique electrons attracted much interest due special electronic optical structures outstanding physical chemical properties review aims provide overview present progress study photocatalytic performance based materials photo degradation solar hydrogen production photo selective reactions also discuss factors affect photocatalytic performance photocatalysts including morphologies structure based nanomaterials moreover current challenges future opportunities based materials capture conversion solar energy also discussed
lymphoma rare aggressive cell lymphoma considered strongly associated hiv infection article explores histological morphology immunohistochemical characteristics hiv aids related lymphoma goal improving diagnosis treatment rare tumor according criteria health organization classification tumors hematopoietic lymphoid tissues six lymphoma cases admitted shanghai public health clinical center comprehensively analyzed conventional hematoxylin eosin staining immunohistochemical staining situ hybridization morphological features six tumors consistent immunohistochemical staining showed six cases negative positive oct melanoma ubiquitous mutated proliferation index higher six cases situ hybridization indicated four cases positive addition three cases myc translocation rearrangement results showed vary makes diagnosis difficult therefore morphological characteristics markers clinical data used combination enable accurate diagnosis especially presence variation approach facilitate timely treatment
objective purpose study measure expression protein term human rat human associated gestational diabetes intrauterine growth restriction methods results using variable volume density analysis performed independently certified total expression protein higher pathological pregnancies corresponding control term methods showing similar results addition expression also higher connective tissue blood vessels compared healthy controls higher placenta whole components pathologies two plates expression lower healthy shown associated significantly increased levels protein suggests play important role normal however term study premature births give better insight human health disease
background objectives primary health care physicians childhood adolescent obesity objective evaluate physicians perspectives managing overweight obesity children adolescents methods services eight public hospitals participated self administered tool maintaining evaluated facilitators barriers managing overweight obese children adolescent patients physicians always recommended weight management overweight obese patient past year involving patient parents others classified positive appropriate practice results respondents appropriate practices lack patient motivation parental involvement major barriers physicians appropriate practices differed perspectives less appropriate practices attending continued education referring patients sub specialty clinical knowledge interventions low concern eating disorders comfortable examining obese patients considered patients readiness weight change conclusion efforts needed physicians managing overweight obesity saudi children adolescents
hidden weighted bit function introduced ieee trans vol art computer programming function seems simplest one exponential binary decision diagram size property interesting cryptographic viewpoint since based attacks receiving attention cryptographic community usable stream functions also satisfy main criteria paper investigate cryptographic properties prove balanced optimum algebraic degree satisfies strict criterion calculate exact nonlinearity give lower bound algebraic immunity moreover investigate resistance fast algebraic attacks simple implemented efficiently high size rather good cryptographic properties take account number variables much larger functions implementation efficiency therefore good candidate used real indeed contrary case symmetric functions allow fast implementation also offer attacker specific possibilities due symmetry structure suspected related dedicated attacks elsevier rights reserved
subjects chronic kidney disease ckd suffer minimal trauma fracture problem differentiate osteoporosis various forms renal bone disease associated ckd mineral bone disorder problem exacerbated fact renal coexist osteoporosis world health organizations bone mineral density bmd criteria osteopenia score osteoporosis score used patients ckd stages ckd stages bmd dual energy ray absorptiometry dxa less predictive underestimate fracture risk development absolute fracture risk algorithms absolute fracture risk predict risk fracture given time usually aims incorporate non bmd risk factors clinical assessment shown useful assess fracture risk ckd underestimate fracture risk advanced ckd trabecular bone score measure grey scale homogeneity obtained spine dxa correlates trabecular independent risk factor fracture recent data demonstrate potential utility trabecular bone score adjustment algorithm subjects ckd parameters bone using peripheral quantitative computed tomography high resolution also able discriminate fracture status subjects ckd however present convincing data addition high resolution parameters dxa bmd improves fracture discrimination advanced estimates bone strength derived measurements micro architecture derived finite element analysis incorporated algorithms future
interferon alpha peg ifn shown induce hematologic molecular responses patients philadelphia negative myeloproliferative neoplasms mpns including polycythemia vera essential thrombocythemia describe series patients long standing mpns among peg ifn initiated developed anemia increased bone marrow fibrosis suggestive early transformation post pet post myelofibrosis six patients treated peg ifn mean duration months range months five patients long standing three calr positive one janus kinase positive one negative calr negative one long standing positive prior starting peg ifn first study report concurrent improvement anemia serial laboratory studies demonstrate increase serum ldh left shifted myeloid cells peripheral circulation approximately months followed gradual normalization findings splenomegaly also increased resolved among responding patients serial bone marrow biopsies available showed little change except improvement grade fibrosis two patients among patients early transformation pet data support efficacy peg ifn improving hemoglobin levels reducing splenomegaly peripheral blood findings therefore considered evidence treatment failure within first year peg ifn therapy
background prevalence comorbid knee pathology examined sports related anterior cruciate ligament acl injuries examined ice players purpose compare concomitant bone ligament injuries intra articular injuries acl injuries suffered ice versus sports study design cross sectional study level evidence methods total patients acl injuries sustained ice identified prospective registry male contact mechanism injury thirteen cases controls sustained acl injuries ice sports respectively included inclusion criteria cases controls male sex contact prior knee surgery magnetic resonance imaging mri within weeks injury surgery within months injury age body mass index bmi mri findings bone medial lateral ligament injuries findings tears injuries compared cases versus controls using tests exact chi square tests results age years bmi differ cases controls cases less lateral bone lateral femoral lateral tibial plateau medial bone medial femoral medial tibial plateau compared controls cases less frequent lateral tears controls significant differences medial tears injuries cases versus controls conclusion male ice players acl injuries less lateral femoral medial tibial plateau bone compared sports injuries also fewer lateral tears trend toward fewer medial tears differences reflect different ability energy contact acl injuries occur ice versus sports
paper presents novel cmos folded cascode operational amplifier leads high provides gain nearly equal two stage amp proposed design implemented cmos technology amp uses folded cascode structure output stage combined differential amplifier input transistors achieve good input common mode range lower noise important feature allows input common mode level close supply voltage proposed topology improves amp used applications simulations using cadence show gain phase margin degree unity gain bandwidth mhz power consumption smaller along layout design shows area acquired chip approximately equal
purpose study evaluate health related quality life among patients ankylosing spondylitis rheumatoid arthritis systemic lupus erythematosus sle prospective cross sectional survey conducted september august patients answered questions regard demographics disease characteristics also completed generic preference based utility instruments multivariate analysis assessed relationship sle respect outcomes different health related quality life instruments general baseline disease characteristics differed across three disease groups compared sle patients patients scored worse higher order summary scores physical pcs mental components total also worse pcs sle patients scored higher utility score compared patients higher patients utility score multivariate analysis found compared patients significantly lower total score pcs sle patients greater pcs greater utility score multivariate analysis found difference across patient groups respect utility score findings suggest among three rheumatic diseases studied patients worse health related quality life patients similar poorer health related quality life sle patient
research based first zero carbon green building school green technology national university actual energy consumption measured explore benefits energy saving design origin building encompasses green energy saving techniques united states department energy dynamic building energy analytical software used execute energy consumption analytical assessment reach energy saving efficiency energy use intensity kwh whole building far kwh found taiwan low mid rise office buildings building begun operation actual readings building energy management system january september first half year accumulated kwh analytical assessment kwh period demonstrating analytical assessed value consistent buildings actual energy consumption readings energy consumption standard experimental research behind school green technology stands world class
lower limb vascular represent serious problem vascular care consequence critical limb ischemia often associated diabetes highly critical health care service aiming prevention limb loss understanding nature complexity scenario paramount effective preventive strategy planning implementation incidence data trends show high variability international reports variability also remarkable granular regional comparison different calculation methods incidence fraction varying epidemiological demographic features populations different socio economic cultural backgrounds disparity vascular care arc main factors contributing variability reports lower limb considered valuable healthcare quality indicator limitations one limitations lower corresponds reduced ability health care providers intervene influencing burden lower limb vascular represent lifetime risk therefore effective achieved importance early recognition peripheral arterial disease delay referral special vascular care effective vascular risk prevention collaboration multidisciplinary teams also emphasized
background aim small intestinal bacterial associated gastrointestinal pathology endoscopic investigation cause changes gut flora including occurrence looked study effect preparation occurrence materials methods prospective study including thirty patients irritable bowel syndrome ibs diagnosed according rome iii criteria two groups designed twenty ibs patients performed ten ibs patients referred patients tested presence using glucose hydrogen breath tests beginning study day patients also tested day week day patients performed day day results peak value assessed mean value calculated significant statistical differences mean values groups patients day mean level significantly decreased preparing patients significant statistical differences mean levels day versus day patients mean level week performing ppm higher obtained preparing ppm statistical significance patients showed statistical differences mean levels day versus day patients significantly lower mean level versus patients day conclusions produce preparing influences level reduces number intestinal bacteria probably trough effect air procedure performing soon result false negative results
inverse problem wave equation outside obstacle boundary condition considered observed data given single solution wave equation generated initial data supported open ball explicit analytical formula computation coefficient point surface obstacle nearest center support initial data given copyright sons ltd
good resource oil especially rich unsaturated fatty acids considered excellent dietary supplement fed high cholesterol diet oil supplementation day orally significantly lower levels serum total cholesterol low density lipoprotein cholesterol compared group regard antioxidant parameters except levels glutathione peroxidase gsh liver day supplementation higher total antioxidant capacity superoxide dismutase gsh levels lower malondialdehyde levels serum liver compared group conclusionthe results present study indicate supplementation improve lipid profiles alleviate oxidative stress high cholesterol diet fed rats society chemical industry
sparse matrix vector multiplication important issue scientific computing engineering applications performance improved using parallel computing implementation optimization gpu research due sparse matrices use single compression format satisfactory hybrid storage format expand range adaptation compression algorithms however imbalance non zero elements parallel computing capability gpu fully utilized parallel computing capability cpu also rising due increased number cores cpu however gpu computing cpu controls process instead contributing computational work leads utilization computing power cpu due characteristics sparse matrices data split two parts using hybrid storage format allocated cpu gpu simultaneous computing order take full advantage computing resources cpu gpu cpu gpu heterogeneous computing model adopted paper improve performance analysis characteristics cpu gpu optimization strategy sparse matrix partitioning using distribution function proposed improve computing performance heterogeneous computing platform experimental results two test machines demonstrate noticeable performance improvement elsevier inc rights reserved
leptin one secreted peptides involved control appetite body weight several studies demonstrated plasma leptin levels elevated obese subjects positively correlated body weight arterial system plays important role regulation vascular tone overexpression involved pathogenesis hypertension associated insulin resistance study performed explore regulatory effects leptin receptor expression binding vascular smooth muscle cells use northern blotting immunoblotting labeled binding assay effect leptin receptor mediated cell proliferation also tested results showed leptin caused significant increase binding time dose dependent immunoblotting showed expression type receptor leptin treated cells increased fold compared controls levels mrna measured northern blotting also increased fold leptin treated cells pretreatment erk inhibitor blocked leptin induced increase binding finally stimulated cell proliferation enhanced leptin pretreatment maximal increase twofold compared controls conclusion leptin increases expression time dose dependent manner effect erk dependent associated increased stimulated cell proliferation findings provide support roles leptin system pathogenesis obesity associated hypertension
hydrogen one important energy sources future least harmful form energy environment hydrogen clean renewable energy supply used non toxic energy storage transport medium water high power dissipation value important problem systems several internal external variables influence electrical behavior cells efficiency namely nature concentration purity electrolyte electrodes type form cell temperature paper presents experimental study regarding hydrogen production waters using photovoltaic panel current study consists seeing effect electrolyte nature volume hydrogen produced experiments conducted university including comparison two alkaline behaviors show potassium effective sodium conditions pressure temperature load current load voltage overall production cells hydrogen standard conditions recording maximum efficiencies respectively
general military regulations contain numerous references aspects nonverbal behavior expressed prescribed behavior considered necessary new reading nonverbal communication new reading possible reveals important aspects regard opportunities education adequate training agreement good knowledge field communication sciences paper aims setting nonverbal profile relation behavioral requirements resulting current forces research method consists documents analysis comprises placement four general normative documents different context communicative one identification explicit implicit nonverbal communication prescriptions included body normative texts analysis nonverbal prescription relationship major classes nonverbal behavior configuration nonverbal profile based behavioral prescriptions respect paper similar normative documents regulations etc developed institutions research institute behavioral social sciences committee opportunities basic behavioral social sciences research etc designed identify role nonverbal communication military context especially context actions different operations following study focus future research field nonverbal communication military context order subsequently build first necessary instrument development nonverbal communicative competence within forces
neural networks becoming central several areas computer vision image processing different architectures proposed solve specific problems impact loss layer neural networks however received much attention context image processing default virtually choice paper bring attention alternative choices image restoration particular show importance motivated losses resulting image evaluated human observer compare performance several losses propose novel error function show quality results improves significantly better loss functions even network architecture left unchanged
observed open clusters initial campaign reducing data high precision challenging due wide point spread function blending light dense regions developed image based reduction pipeline applicable sparse fields applied pipeline data rich super containing two open clusters neighboring paper present image reduction pipeline demonstrate technique achieves ultra high precision sources super extract raw light curves taken trend systematic effects compare results prior reductions published literature corrected sources magnitude range achieve best hour window running rms ppm falling ppm magnitude range hour light curves achieve highest precision moreover corrected sources higher precision investigated work represents first published image analysis super method particularly useful analyzing observations carried campaign raw light curves final results processes publicly available http
mental illness prevalent complex phenomenon psychologists developed distinct approaches toward understanding illness rooted divergent introduction special issue clinical psychological science practice provides brief overview practitioner gap explores one step many toward bridging divide seven compelling case featured special issue apply empirical findings case formulation treatment selection assessment across complex varied clinical presentations issue thereby demonstrates feasibility integrating research clinical expertise mental healthcare wiley periodicals inc
paper analyses influence selected magnet materials design slow speed permanent magnet synchronous generators use wind applications design procedure including setting initial design parameters machine calculations machine dimensions magnetic flux air gap electrical parameters selection criteria permanent magnets use permanent magnet generator presented according calculations generator prototype constructed four different rotors different magnetic materials used machine tested using different rotors influence different magnetic materials output characteristics machine shown price power analysis used magnetic materials provided conclusions possible machine design benefits drawbacks presented study investigations carried show magnets preferred ones terms performance weight reduction whereas considerable alternatives available design performance criteria flexible
alignment many short sequences dna called reads long reference genome common task molecular biology problem expanded handle typical workloads reads execution time becomes critical paper present novel reconfigurable architecture minimal perfect sequencing existing solutions attempt align high percentage reads using small memory footprint focuses performing fast exact matching using human genome reference short reads hundreds thousands times faster current software implementations thousand times faster gpu implementations whereas require hours reference genomes reference human genome minutes opening possibility using new reference sources genetically similar newly sequenced data
work introduce approach nonlinear model predictive based called state dependent equation approach model first cast form similar linear state space representation algebraic equation constructed based similarity linear quadratic regulator obtain stable method requires solution equation sampling period simulation results quite
programming heterogeneous clusters inherently complex architectures require programmers manage distributed memory computational units different nature extensive research development frameworks raise level abstraction cluster based applications thus enabling use programming models much convenient traditional one based message passing one proposals array data type represents globally distributed arrays possible perform wide range data parallel operations paper explore first time development heterogeneous applications clusters using order use high level api also parts application developed using heterogeneous programming library operates top providing much better experiments show approach attractive alternative obtains large benefits respect traditional implementation based mpi presenting average performance just around
examine predictive ability memory deterioration strength disability progression among utilized home help service methodswe prospectively followed cohort community dwelling older people aged older certified support level care level home help service users provided consumers memory capability strength chronic conditions indices surveyed baseline disability progression defined certified care level higher year follow assessed older adults included excluded multivariate cox regression analyses higher eligibility level memory deterioration independently associated higher hazard ratio chronic conditions entered model cancer low strength additionally associated conclusionsthe findings present study show memory deterioration risk factor disability progression also strength risk factor consideration chronic conditions cause effect relationship factors disability progression future challenging issue int
traditionally production control construction sites challenging still remains challenging hoc production control methods usually used informal foster uncertainty prevents smooth production flow lean construction methods last system partially problem involving site teams decision making process report back production management system however systems relatively long planning cycles respond dynamic production requirements construction daily hourly control needed new solutions proposed etc types construction management systems require proximity availability computer devices workers paper authors investigate communication framework underlying construction management systems improved fully partially automate various communication functions across construction project lifecycle enable lean close real time reporting production control information end present paper provides evidences internet things iot related standards contribute improvement paper provides first insights various construction scenarios proposed communication framework beneficial various actors core business perspectives lean construction management management entire building lifecycle elsevier rights reserved
box family transcriptional factors required fruit regulating cell specification valve margin arabidopsis thaliana search database using gene query revealed several sharing high similarity two highly homologous obtained pcr race named respectively work focused sequence alignment phylogenetic analysis indicated highly identical southern blotting demonstrated least two copies genome semi pcr showed expressed roots stems leaves seeds localized nuclei cells fused expressed using system
young children exert little control household tobacco smoke exposure considered developmental using longitudinal study birth cohort examine prospective associations early childhood smoke exposure later antisocial behavior parents children reported presence household smokers seven follow ups ages age children self reported five aspects early antisocial adjusting confounders every standard deviation increase household smoke exposure prospectively associated standard deviation unit increase conduct problems confidence interval standard deviation unit increase proactive aggression standard deviation unit increase reactive aggression standard deviation unit increase school standard deviation unit increase dropout risk long term findings warrant fostering parental awareness developmental risks policy makers health practitioners school curricula equally integrate ideas curriculum
use vesicle mediated transfer assembled nuclear envelope final maturation cytoplasm molecular basis novel cytoplasmic transport beginning elucidated detail viral nuclear complex conserved within classical mediates vesicle formation inner nuclear membrane polymerization hexagonal lattice followed fusion vesicle membrane outer nuclear membrane mechanisms inclusion vesicle membrane fusion however largely unclear interestingly similar transport mechanism demonstrated nuclear export large complexes drosophila neuromuscular junction formation indicating widespread presence novel concept cellular cytoplasmic transport
system dynamics computer simulation modeling methodology one suitable effective ways dynamics modeling complex non linear natural technical organization systems studying dynamics behavior marine electric power systems one complex dynamic non linear technical systems requires application effective modeling methods aim paper show efficiency system dynamics computer simulation modeling dynamics behavior marine diesel drive generating set one complex non linear marine technical systems marine diesel drive generating set presented qualitative quantitative system dynamics computers model special automation aspect provided two pid regulators electronics universal pid regulators one used diesel motor speed frequency regulation used synchronous electrical generator voltage regulation computer simulation model marine diesel drive synchronous generating set suitable education simulator software especially marine students marine system engineers provides means conduct numerous simulations various productive scenarios
referring two recent publications propose clinical reproductive immunology decades reproductive medicine including assisted reproduction failed accept embryo implantation immune system driven process dependent establishment maternal tolerance toward fetal semi allograft complete allograft cases donation pregnancy represents biologically unique period temporary period gestation restricted tolerance otherwise known association parasitic infections rather investigating immune pathways necessary induce rather unique state tolerance toward rapidly growing parasitic antigen load fetus field instead concentrated irrelevant secondary immune phenomena immunological noise therefore interesting recent research offering new potential insights maternal tolerance pregnancy mostly published outside field reproductive medicine research offers evidence existence inducible maternal tolerance pathways ability improving maternal potentially reducing late pregnancy complications premature labor due premature maternal tolerance increasing evidence also suggests tolerance inducing immune pathways similar successful pregnancy successful organ transplantation likely also tolerance self prevention autoimmunity identifying pathways therefore greatly benefit three clinical areas research reproductive immunology accordingly
background muscle degeneration important parameter consider planning shoulder arthroplasty hypothesis hypothesized muscle degeneration correlated patients planned anatomical total shoulder arthroplasty materials methods developed semi automated quantitative method measure muscle degeneration retrospectively analyzed preoperative shoulder scans patients primary osteoarthritis standardized sagittal slice perpendicular axis two observers measured cross sectional areas residual muscle tissues normalized estimated area healthy muscles muscle degeneration quantified semi automated manner divided atrophy fatty infiltration determined distance head center surface center projected slice normalized head radius tested potential correlations muscle degeneration results muscle degeneration primarily due atrophy varied varied mainly posterior superior orientation significant weak correlation amount degeneration inter intra observer reproducibility muscle degeneration measurements excellent range respectively conclusion new semi automated method allows quantitatively measure muscle degeneration primary osteoarthritis muscle degeneration weakly correlated patients planned anatomical level evidence level type study diagnostic retrospective study elsevier masson sas rights reserved
introduction cervical cancer serious public health concern due opportunistic screening still force led twice higher average incidence rate cervical cancer europe despite fact early detection treatment services available additional cost majority women use inadequate screening services objective study aimed examine link knowledge test perception barriers womens participation screening materials methods study included women aged place residence city attending medical examination university clinic gynecology obstetrics front june december survey instrument collect data adapted questionnaire assessment knowledge barriers test patients divided three groups study group consisted women attending three years women never participated screening control group included women regularly participating screening results women regularly participating screening adequate knowledge test women never participated adequate knowledge significant statistical difference test awareness group respondents regularly participated comparison respondents never participated screening regarding knowledge human papillomavirus hpv women know test used detection hpv abnormal test result due hpv majority women poor knowledge test role early detection considered test used diagnose authors found significant statistical correlation participation women screening barriers women irregular never participated barriers lack time difficult access healthcare facilities lack knowledge test procedure discomfort anxiety test results women regularly participated prejudice choosing unlike two groups preferred female conclusion study showed level knowledge test women important factor associated regular participation screening necessary take educational measures order raise awareness women regarding risk factors overcome fear shame ultimate aim reduce frequency mortality rate caused
new national paediatric asthma management guideline based international global initiative asthma guideline launched netherlands studied whether asthma control treatment regimens improved introduction guideline comparing survey data guideline introduction comparable groups children years asthma included introduction guideline children parents completed questionnaires asthma symptoms medication healthcare use performed patients analysed level asthma control improve proportion partly controlled characterized children partly controlled children partly controlled according criteria step treatment controlled patients applied compared step treatment uncontrolled patients improve control improve introduction new guideline compared improvement observed step treatment patients controlled disease
nanostructured materials relatively new class materials exhibit advanced mechanical properties thus improving performance capabilities products potential applications automotive aerospace defense industries among severe plastic deformation methods currently used achieving nanoscale structures roll bonding favorable method produce grain refinement continuous production metallic sheets bulk scale article model describes evolution material strength due processing via roll bonding developed experiments conducted grade selected set conditions results showed significant grain refinement microstructure similar two fold increase tensile strength compared received material developed model validated using experimental data exhibited good fit entire range processing cycles validate model ensure robustness wider array materials beyond review efforts processing carried five materials different initial microstructures mechanical properties even crystalline structures model still able capture strengthening trends considered materials society manufacturing engineers published elsevier ltd rights reserved
based orthogonal superposition theorem three alternating magnetic components universal uniform magnetic spin vector using tri axial coils achieving successive digital control orientation rotational speed magnetic flux density universal magnetic spin vector increasing magnitude orientation accuracy magnetic spin vector paper presents mathematical model associated magnitude error orientation error universal magnetic spin vector along double error compensation method magnitude orientation universal magnetic spin vector three alternating magnetic components double error compensation method includes current magnitude compensation three different structural coefficients tri axial coils current phase compensation two relative phase differences linear polarization results shown double compensation method increase magnitude orientation accuracy rotating magnetic vector effectively achieve accurate posture adjustment steering control capsule robots environment
microstructure based modeling method developed predict mechanical behaviors lithium ion battery existing battery modeling methods capture structural features overcome issue propose image based microstructure representative volume element modeling method facilitates understanding complex macro mechanical behaviors perspective microstructural features generic image processing workflow developed identify different phases microscopic image processed image supplies microstructural information finite element analysis fea mechanical behavior microstructure evolution obtained simulation evolution microstructure features quantified using stochastic microstructure characterization methods proposed method successfully captures anisotropic behavior tensile test provides insights microstructure deformation growth apply proposed method commercially available demonstration analysis results validated using experimental testing results reported literature elsevier rights reserved
aims population surveys become frequently used method explore stigma help seeking illness beliefs related mental illness methodological quality however differs greatly studies current knowledge seems heavily biased towards high income countries critical appraisal advances shortcomings psychiatric attitude research missing review state art population based attitude research mental health methods systematic review peer reviewed papers reporting representative population studies beliefs attitudes mental disorders published january december results decade covered review considerably papers psychiatric attitude research published whole time period papers originated europe north america australia papers included data low middle income countries vast majority papers used correlational cross sectional analyses used experimental quasi experimental designs data papers obtained face face interviews followed telephone online surveys almost half papers case served stimulus eliciting responses instruments meeting established psychometric criteria used frequently studied disorder depression paper followed schizophrenia papers reported time trend analyses attitudes beliefs cross cultural comparisons common focus research mental health literacy total papers followed various forms stigma scarcity papers based established theoretical frameworks conclusions current attitude research studies uses profound innovative methodology still blind spots large proportion conventional studies discuss current future methodological challenges psychiatric attitude research needs innovative sound studies needed provide empirical basis evidence based interventions aimed reducing misconceptions mental disorders improve attitudes towards
rainwater harvesting modified contour known dead level practiced last two decades studies shown marginal soil moisture retention benefits using technique results crop yield benefits lacking paper presents results field study assessing impact dead level soil moisture crop yield carried within river basin experiments carried two study sites one containing soil another containing sandy soil three treatments dead level plots non plots plots traditional graded used site three treatments maize crop managed using conventional farming methods application three treatments done time crop monitoring carried sub plots measuring established every treatment development crop monitored harvesting time data plant height leaf moisture crop yield collected analysis data shows site soil soil moisture accumulated heavy rainfall dead level contour plots compared control graded contour plots higher yield dead level treatment compared non treatment significantly higher non treatment suggests adopting dead level situ rainwater harvesting technique results crop yield benefits fields soil type conditions enable runoff generation likely benefit soils low runoff generation elsevier ltd rights reserved
background age related arm degeneration leading cause irreversible developed countries despite several studies morphology aetiology unknown factor contributing pathogenesis remain characterised recent studies demonstrated cholesterol esters lipids present within membrane deposits dietary fat intake associated product gene leptin recently discovered peptide participating human metabolism direct relationship serum leptin diet lipoprotein metabolism role leptin course previously investigated purpose cross sectional case control study investigated whether serum leptin level associated new possible risk factor assess relationship disease severity methods total patients arm men women age sex matched healthy control subjects without men nine women similar ethnic background enrolled multicentre study body mass index bmi weight height calculated group presence assessed basis colour photographs using international classification system patients classified early arm late using clinical examination grading photographs serum leptin levels measured enzyme linked immunosorbent assay kit mann whitney test chi test used statistics indicated considered significant results age sex ratio bmi groups comparable patients significantly lower leptin levels mean control subjects addition late patients significantly lower leptin levels early arm patients control subjects conclusion leptin seems possible newly associated factor course arm involved lipid composition lesions especially late
long noncoding rnas emerged recently new class genes regulate cellular processes transcript antisense rna approximately long noncoding rna transcribed locus upregulated various diseases however role parkinsons disease remains unclear mouse model developed intraperitoneal injection expression detected mice human neuroblastoma cell lines pretreated effect expression examined cells overexpressing knockdown mtt flow cytometry assay performed measure cell viability apoptosis cells found regulated tissue induced mice cells exposed presence overexpression cells expression increased compared control knockdown showed protective effect cell viability cells pretreated knockdown provided protection induced neuronal apoptosis caspase activity finding promoted induced add understanding molecular mechanisms findings suggested inhibition levels effective disease modifying strategy
aim risks fasting patients adrenal insufficiency unknown aims study evaluate risks patients determine risk factors finally set recommendations methods cross sectional study patients known treated adrenal insufficiency patients responded item questionnaire concerning knowledge disease fasting last month results women men mean age years one hundred thirty eight patients advised physician fast ninety one patients tried fast complications occurred cases cases intense symptoms dehydration symptoms one patient hospitalized fifty five patients able fast whole month age gender duration disease primary origin associated hypothyroidism diabetes mellitus hypertension diabetes daily dose significantly differ non full month partial month complications without complications frequency adequate knowledge disease significantly higher full month partial month without complications complications conclusion patients adrenal insufficiency fasting cause complications especially level knowledge disease low
safe potable water essential good health worldwide school aged children especially developing countries suffering various water borne diseases study drinking water supplies primary school children monitored district ensure safe potable water standard analytical methods applied determining physicochemical parameters water samples determination essential physicochemical parameters samples collected randomly selected tube wells primary schools metal contents especially arsenic iron water samples analyzed atomic absorption spectroscopy range physicochemical parameters found water samples follows electrical conductivity chloride hardness total dissolved solids level metals tube water samples follows drinking water parameters district meet requirement world health organization drinking water quality guideline drinking water quality standards
significant cause case rectal found culture young man sex men previously reported literature nucleic acid amplification tests now standard care sexually transmitted infection testing test therefore missing important infections important implications rectal hiv transmission among men sex men engaging anal intercourse study role rectal pathogen warranted
introduction play important role clearance immune complexes apoptotic cell debris impaired clearance leads exposure native antigen development anti antibody formation anti antibody studied systemic lupus erythematosus sle significance anti indian sle patients clinical manifestations clear aim aim study investigate associations anti antibody clinical serological markers sle materials methods retrospective study sle patients fulfilling either american college rheumatology systemic lupus international clinics classification criteria recruited inpatients outpatients services clinical immunology rheumatology department medical college india march january anti antibody assayed elisa diagnostics gmbh germany logistic regression analysis performed find association anti antibodies serological clinical parameters sle including lupus results sixty nine patients sle patients anti levels higher patients compared without anti antibody also significantly associated positive immunofluorescence staining renal biopsy specimens overall renal systemic lupus erythematosus disease activity index low manifestation independently associated anti levels serum conclusion renal low manifestations independently associated raised anti antibody sle patients
present study investigated impact diagnostic labels traits age gender various mock decisions undergraduate students members community read simulated trial transcript involving case assault transcript differed terms diagnosis psychopathy antisocial personality disorder conduct disorder diagnosis age gender male female effects variables decisions regarding credibility choice risk future violence treatment investigated results indicated psychopathic rated less diagnostic conditions described also likely found likely receive higher ratings risk future violence regardless age gender significant main effects interactions concerning age gender variables implications use psychopathy evidence within criminal justice system discussed
characteristics permanent magnet synchronous machine investigated using finite elements method done resolve partial rotor resulting short magnetic field first turn phase belt paper first introduces electrical machine design parameters winding construction establishes model using maxwell software harmonic contents waveform studied investigating magnetic flux density distributions short circuit fault varied trajectories flux densities reference points rotor permanent magnet located different points load air gap magnetic flux density electromagnetic torque three phase currents harmonic content waveform addition reason short circuit determined provide theoretical basis diagnosis
known children mental developmental problems risk abuse neglect attention deficit hyperactivity disorder one frequent neurodevelopmental disorders children adolescents purpose study examine whether children diagnosed adhd risk terms child abuse neglect compared controls case control study children applied child adolescent psychiatry unit training research hospital january june diagnosed adhd psychiatric comorbidity except disruptive behavior disorders healthy children compared abuse assessment questionnaire applied children approval families received determined children diagnosed adhd exposed physical emotional abuse statistically significant way compared controls exposed physical emotional neglect lower rate compared healthy children difference healthy children terms family violence exposed sexual abuse children diagnosed adhd exposed physical emotional abuse higher rate studies emphasize role parents topic parental education treatment programs change results elsevier ltd rights reserved
present novel parallel address architecture based graphics processing unit gpu via compute unified device architecture cuda architecture consists two functions host function device function host function executed cpu construct update data structure address executed device function gpu host device functions executed simultaneously fully utilize computational resources shorten time based data structure optimized cuda developed based data structure uses multi bit shorten depth also improves efficiency texture cache gpus experimental results show low end gpu achieve throughput billion packets per second routing tables high end gpu double performance employing dual data structures implementation support several hundred thousand updates per second
foods comprehensive case provides opportunity students apply several financial concepts professional standards real world context percent percent respectively delaying recognition cost acquired later accounting periods case requires students determine whether external fulfilled responsibility obtain reasonable assurance financial statements free material students need determine whether opinion financial statements internal controls professional standards addition students required evaluate whether obtained sufficient understanding business industry needed professional used appropriate analytical procedures discharge professional responsibilities case presents opportunity achieve several learning objectives including development research critical thinking communication problem solving skills case appropriate use graduate undergraduate course financial also used examination course course accounting curriculum
automated regulatory compliance checking requires automated rule extraction regulatory textual documents contract specifications automated rule extraction challenging task requires complex processing text proposed automated compliance checking acc approach first step rule extraction process automatically classifying different documents parts documents contract predefined categories environmental safety health etc preparing text analysis rule extraction categories defined semantic model normative reasoning paper presents semantic machine learning based text classification algorithm classifying general conditions supporting acc construction classification problem transformed set binary classification problems different machine learning algorithms text preprocessing techniques methods text feature scoring methods feature weighting feature sizes implemented evaluated different thresholds developed classifier achieved recall precision respectively testing data american society civil engineers
background type autosomal dominant disease caused abnormal expansion repeats protein kinase gene clinical manifestations highly variable unstable nature expansion causes wide genotypic phenotypic presentations make molecular methods essential diagnosis far studies molecular diagnosis chinese patients reported therefore carried study using two different methods molecular diagnosis verify validity detecting expansion chinese patients showing signs methods total chinese individuals referred molecular diagnosis using conventional polymerase chain reaction pcr accompanied southern blotting primed pcr pcr evaluated sensitivity limitation method using percentage results conventional pcr samples showed one fragment corresponding normal allele correctly diagnosed pcr three homologous non samples ruled southern blotting analysis successfully made correct diagnoses sensitivity using alpha labeled probes labeled probes conclusion molecular analysis necessary diagnosis pcr reliable sensitive easily performed method molecular diagnosis
common disorder appearing mainly women although less frequently found women ovary syndrome objective test hypothesis protect hypothyroidism material methodsthe data three prospective follow studies one register study compared women criteria women syndrome random population sample women men study findings verified rejected females region proportion hypothyroidism calculated thyroid peroxidase antibodies serum measured age found women men men women syndrome irrespective postmenopausal women population women without region less frequently seen women men compared women general population among women syndrome explained altered autoimmunity chromosome androgens seem protect hypothyroidism
study evaluated whether common self report measures television game violence exposure represent reliable valid measurement tools three self report estimates user rated agency rated assessed terms test retest reliability criterion validity relationship coded media diaries construct validity relationship aggression gender total adolescents participated two wave survey completed two media diaries game violence three self report measures reliable valid television violence direct estimates achieved test retest reliability construct validity criterion validity established television violence measures media diary valid criterion television violence findings indicate direct estimates valid measures game violence whereas television violence direct estimates valid conclude discussion ways improve upon media violence exposure measurement
background earlier studies shown absolute number neutrophil ngs increase attack hereditary angioedema due inhibitor deficiency inh hae whether ngs undergo activation attack yet investigated however neutrophil inh contribute dysregulation system hence edema formation aim investigate possible activation ngs attacks methods studied blood samples obtained patients inh hae symptom free periods attacks along samples healthy volunteers count crp factor tnf alpha levels measured results higher attacks symptom free periods observed levels strong positive correlation levels attacks furthermore tnf alpha levels also elevated attacks compared symptom free periods contrast factor levels similar samples obtained attacks symptom free periods conclusion increased associated elevated levels suggests neutrophil activation attacks strong positive correlation levels together elevated concentration indicate expression neutrophil extracellular processes contribute activation system leads onset episode
present adaptive game teaching self regulation stress approach consists monitoring users physiology adapting game using positive feedback loop rewards behaviors states high arousal evaluate approach using game three modalities activity heart rate variability breathing rate three measured wearable sensors represent different degrees voluntary control selectivity toward arousal conducted experiment trial participants compare three modalities standard treatment deep breathing control condition game without results indicate breathing based game effective inducing relaxation treatment four groups participants group also showed greater retention relaxation skills without subsequent stressor
therapeutic alliance demonstrated association favorable psychotherapeutic outcomes treatment eating disorders eds however questions remain inter relationships early alliance early symptom improvement treatment outcome conducted meta analysis relations among constructs possible moderators relations psychosocial treatments eds twenty studies met inclusion criteria supplied sufficient supplementary data results revealed small moderate effect sizes indicating early symptom improvement related subsequent alliance quality alliance ratings also related subsequent symptom reduction relationship early alliance treatment outcome partially accounted early symptom improvement regard moderators early alliance showed weaker associations outcome therapies strong behavioral component relative therapies however alliance showed stronger relations outcome younger older patients variance shared early symptom improvement sum early symptom reduction enhances therapeutic alliance treatment outcome eds early alliance require specific attention younger patients receiving oriented treatments
climate change become global issue influencing human survival development urban carbon emission main factor fundamental building block city neighborhood basic space create truly sustainable community also starting point use low carbon ideas technologies address climate change promote construction low carbon city considering significance neighborhood planning reducing carbon emissions proposed low carbon neighborhood planning technologies six aspects layout planning traffic planning architecture planning design environment planning municipal engineering planning construction management moreover built indicator system low carbon neighborhood based technologies perspective carbon source control carbon expansion used analytic network process analyze internal feedback obtain priorities system used indicate low carbon degree provide measures improvements furthermore carried case study using proposed method neighborhood province china practice proved system promote sustainable low carbon development urban neighborhood provide government effective tool elsevier ltd rights reserved
review give overview field computational enzymology start describing birth field emphasis work chemistry present key features state art field showing theory accompanied experiments taught far enzymes also briefly describe computational methods quantum mechanics molecular mechanics approaches reaction coordinate treatment free energy simulation approaches discussing open questions challenges authors published elsevier inc
real complex filters versatile building blocks multitude dsp applications focus efficient implementation linear phase minimum phase filters recalled sample rate alteration computational loads compared optimum signal flow graphs presented comparisons carried corresponding complex filters hilbert transformers centred frequencies omega without additional frequency offset delta omega expected smaller transition width higher relative advantage approach terms computation yet exist ranges specifications linear phase filters outperform minimum phase counterparts even without taking account linear phase stability advantages filters
nowadays manufacturers forced shift traditional product manufacturing paradigm goods services continuum providing integrated combination products services adoption service based strategies natural consequence higher pressure companies facing global markets especially due presence operate low region services specifically manufacturing companies moving value chain order move competition costs innovation proliferation new emerging technologies paradigms together wider dissemination information technology significantly improve capability manufacturing companies services products authors present knowledge based data driven platform support design development product extended services solutions
investigate inside dynamics solutions equations understand genetic consequences population generations undergoing range expansion obtain inside dynamics decompose solution neutral genetic components inside dynamics given spatiotemporal evolution neutral genetic components consider thin dispersal kernels variety per capita growth rate functions classify traveling wave solutions either find effect population genetics adding dynamics impact genetic diversity expanding population however growth functions strong effect cause traveling wave solution front preserving genetic variation population case contribution neutral fraction computed simple formula dependent initial distribution neutral fractions traveling wave solution asymptotic spreading speed
objective perform systematic review meta analysis studies investigating youths bipolar disorder compared healthy controls hcs method systematic literature search conducted pubmed medline psycinfo embase databases inception march original peer reviewed articles investigated youths compared hcs effect sizes individual tests extracted addition results grouped according cognitive domain review prisma statement guidelines results total studies met inclusion criteria overall youths significantly impaired verbal learning verbal memory working memory visual learning visual memory moderate large significant impairments observed attention vigilance reasoning problem solving processing speed heterogeneity moderate large estimates differences definition across studies explained heterogeneity estimate verbal learning memory also found evidence potential sources heterogeneity several estimates including occurring attention deficit hyperactivity disorder adhd anxiety disorders use medications addition use different neuropsychological tests appeared contribute heterogeneity estimates attention vigilance domain conclusion youths exhibit significant cognitive dysfunction encompassing verbal learning memory working memory visual learning memory domains data indicate subset individuals neurodevelopmental factors contribute cognitive dysfunction
purpose mutations genes associated breast ovarian cancer susceptibility recent studies suggested mutation associated primary ovarian insufficiency evaluate fertility several studies validated anti hormone direct biomarker ovarian aging considered quantitative marker ovarian reserve hypothesize gene mutations negatively associated levels methods evaluated women aged years participating ovarian cancer early detection prevention program patients history cancer ovarian surgery exposure chemotherapy excluded linear logistic regression modeling performed evaluate association levels age mutation logistic models outcome low defined years times odds low still strongly associated low conclusion women mutation lower hence ovarian reserve women without mutation therefore young adults mutation regarding potential decrease ovarian reserve
features broader autism phenotype people epilepsy support shared mechanisms epilepsy autism spectrum disorder inform mechanisms underlying comorbidity epilepsy autism spectrum disorder asd conducted meta analyses test whether impaired facial emotion recognition theory mind tom key phenotypic traits asd common people epilepsy controls contrasted findings relatives individuals asd asd relatives compared controls furthermore examined relationship demographic age sex epilepsy related factors epilepsy onset age duration seizure origin tom thirty one eligible studies including individuals temporal lobe epilepsy asd relatives identified systematic database search analyses revealed reduced tom compared controls reduced tom asd relatives tom poorer asd relatives weak associations found tom epilepsy related factors findings suggest shared mechanisms epilepsy asd independent intellectual disability elsevier ltd rights reserved
work presents novel strategy fragments identifying composed drawing usually inside group representing name aiming identify proposed method based several techniques frequently used computer vision consists three main stages first picture taken input contour localized second stage individually extracted identified finally interpreted sequence established according previously generated benchmark sequence corresponds name although method initially conceived deal high low relief writing stone also applied approach affected variable lighting conditions intensity completeness objects proposal tested images obtained list promising results give new possibilities recognize opening new way longer texts particularly useful environments additionally devices used acquiring visual information smartphones part navigation system users located indoor environments means combination positioning systems depth cameras end document
multi tap microwave photonic filter center frequency tuned single parameter proposed demonstrated based polarization modulation simply adjusting amplitude wave signal polarization modulator tuned shape free spectral range unchanged proposed system advantages terms simple operation fast large bandwidth
computational grids established intention providing shared access hardware software based resources special reference increased computational capabilities fault tolerance one important issues faced computational grids main contribution survey creation extended classification problems computational grid environments proposed classification help researchers developers grids understand types issues anticipated moreover different types problems interaction timing related identified need handled various layers computational grid survey analysis examination also performed pertaining fault tolerance fault detection mechanisms conclusion reliable grid established emphasis fault identification moreover survey reveals adaptive intelligent fault identification tolerance techniques improve grid working environments
paper introduce quasi electrical model high efficiency back contact solar cell distributed electrical network based two diodes circuit elementary units allows accounting resistive losses due transport back surface field fingers moreover model electrical losses attributed calibrated electrical components model according experimental measurements real devices validity model demonstrated good agreement simulation experimental results dark measurements without model now easily applied simulate optimize different metal grid layouts authors published elsevier ltd
paper presents real time image acquisition system improved image quality assessment module acquire high quality near infrared nir images thermal imaging plays vital role wide range medical military applications demand high throughput image acquisition image processing continuously increased especially critical medical military purposes real time constraints required work implements nir image quality assessment module utilizes improved two dimensional entropy mask based edge detection algorithms effectiveness proposed image quality assessment algorithms demonstrated implementation complete finger vein biometric system proposed model implemented embedded system field programmable gate array prototyping platform including image quality assessment module proposed system able achieve recognition accuracy equal error rate handle real time processing frames live video rate achieved hardware acceleration proposed image quality assessment algorithms via novel streaming architecture
background rheumatoid arthritis rheumatic conditions fundamentally affect patients quality life physiological needs also negatively associated work ability costs poor work ability sum treatment costs pose economic burden society patients work ability appears multifactorial symptoms pain swelling stiffness play major role directly affect functional disability also patients typically suffer reduced muscle strength lower extremity function strengths especially impair quality life however role muscle strength disease activity determinants work ability yet studied objective primary objective study compare work ability working age participants seropositive high low disease activity secondary objective evaluate association muscle strength functional ability work ability methods cross sectional study conducted outpatient clinic day hospital approximately seropositive patients aged years clinical disease activity index measure rheumatoid disease activity assessed patients routine visits clinic work ability functional disability evaluated self reported questionnaires physical tests work ability index score health assessment questionnaire disability index survey health ageing europe instrument short physical performance battery muscle strength determined measurements hand strength muscle contraction strength sleep quality medical outcomes study sleep scale sexual functioning physiological needs additionally determined self reported questionnaires results study funding already enrollment completed data currently evaluated conclusions study evaluate association work ability modifiable parameters muscle strength functional ability provide insights work ability associated risk factors evidence association motivate research findings encourage interventions focused specifically improving muscle strength lower extremity function positively affect work ability
genetic changes epigenetic changes also play major role causing epilepsy great importance generally many genomic positions associated disease genetic products cell contribute affected epigenetic mechanisms demonstrate major influential role epigenetic mechanisms causing epilepsy seems like many epigenetic properties discovered yet thus various studies required discover epigenetic mechanisms relationship mechanisms role causing various diseases epilepsy research various papers important inhibitory mechanisms epigenetic cases involved pathogenicity mechanism various syndromes period extracted different resources pubmed science direct using keywords epilepsy histone current therapeutic medicines satisfactory need new therapeutic methods care patients thus present research conducted order discover epigenetic mechanisms goal achieving new effective medicines study reveals role dna methylation epigenetic mechanisms involved causing epilepsy furthermore epigenetic changes changes following translation dna methylation appropriate goals new treatments capable changing compared genetic factors like mutation challenges field resulted vast researches conducted similar engaged mechanisms associated epigenetics epigenetic mechanisms play major role development growth brain goal future achieve epigenetic general treatment nervous disorders epilepsy thus manipulating epigenetic mechanisms next goal epilepsy treatment side effects treatment systematic epigenetic medicines also need predicted question enzymology specifically diagnoses damaged areas brain targets selected genes associated epilepsy necessary step taken addressed future
present research examines relationship approach two dimensional model issue received little empirical attention study created three unknown groups humanized human nature human uniqueness traits attribution primary secondary emotions measured expected participants attributed secondary emotions humanized compared groups importantly groups attributed similar amounts secondary emotions study groups described terms capacity express secondary emotions measured attribution traits results showed group traits results highlight importance considering common aspects approaches understanding processes
nowadays technology evolves rapidly increases need qualified professionals field ict employment professionals projected grow worldwide till much faster average main reason rapid growth large increase market demand computer software mobile applications regard organizations established businesses looking alternative ways educate grow number people particular students involved learning computer programming hand students regardless age access internet via tablets smartphones turns intuitive everyday learners gives access resources content information form web based platforms mobile learning applications social media online games others providing abundant diverse learning experience however matter fast technology evolves many alternative teaching techniques introduced constantly major challenge education still remains motivation context students driven learn playing online games interacting via social media expressing via digital resources rather traditional educational methods relatively new gaining popularity form education use interactive online learning platforms possibility learning computer programming skills building digital games platforms designed using approach provide vast methods based rich user experience interaction simulation purpose paper present innovative learning platforms learning computer programming explore features advantages drawbacks investigate impact interactive learning experience create
cells electrochemical oxygen demand measurements based total decomposition doped electrode developed rapid measurement organic pollutants low concentrations using improved cells designed efficient mass transfer potassium hydrogen phthalate theoretical determined relatively short time thus measurements using cells useful estimating organic water pollution industrial waste lake water
age menopause related impairment working memory mediated dorsolateral prefrontal cortex occurs humans primates long term cyclic beta estradiol treatment cognitive deficits aged ovariectomized monkeys restoring highly plastic synapses tested whether distributions protein coupled estrogen receptor within layer iii synapses sensitive age estradiol coupled cognitive function ovariectomized young aged monkeys administered vehicle estradiol first tested delayed response test working memory quantitative serial section microscopy used determine distributions synaptic containing synapse density reduced age partially restored estrogen treatment majority synapses expressed localized cytoplasm mitochondria also abundant within cytoplasmic density domains dendritic levels differ age treatment none variables examined tightly associated cognitive function however greater representation accompanied higher synapse density data suggest positioned support diverse functions key synaptic plasticity
simple differential phase shift signals demonstrated consists two parallel delay followed balanced detectors limiting driving amplifiers dual parallel modulator noise suppressed optical signals experimentally show improves receiver sensitivity input optical signal noise ratio signal speed numerical simulation conducted higher speed operation study impact bandwidth electrical circuits inside performance electrical power consumption assessed shown consumes similar amount electrical power consumed optical version using semiconductor optical amplifiers nonlinear element
recent research reveals playing prosocial video games increases prosocial cognitions helpful behaviors results consistent social cognitive models social behavior general learning model social cognitive learning models suggest addition influencing cognitions media content also influence affect however past studies prosocial video games failed find significant effect affective measures present research examined effects prosocial neutral violent video games state hostility positive affect also examined moderating effects trait aggressiveness trait helping trait helping prosocial games reduced state hostility increased positive state affect violent video games opposite effects effects moderated trait physical aggression participants reported relatively positive affect less state hostility participants reported relatively mean feelings wiley periodicals inc
background aims aim study investigate hong kong ability recognize different mental disorders examine whether relationship mental health literacy tendency describe explain symptoms mental disorders physical terms methods total participants took part study post traumatic stress disorder depression obsessive compulsive disorder dependent personality disorder personality disorder generalized anxiety disorder bipolar disorder social disorder personality disorder schizophrenia antisocial personality disorder results overall best identified personality disorders worst significant negative correlation found participants rate offering physical rather psychological explanation mental disorders better recognized others depression however majority disorders poorly recognized labelled rest correct response rates lower half mental disorders correct response rates lower conclusion accordance many studies area study found asian participants poor recognizing mental disorders probably due fact mental illnesses kinds remain topic
hand injuries account sports injuries common contact sports sports high risk falling appropriate management requires knowledge type injury demands sport position competitive level athlete future athletic demands expectations role rehabilitation protective return play management athlete requires aggressive diagnostic intervention treatment article describes injuries including dislocations dislocations ligament injuries dislocations evaluation treatment outcomes
starting computational analysis matching develop novel variational framework able model perceptual context driven effects extended non physical judgments important feature variational framework description phenomena suitable balance contrast dispersion optimal balance defined simultaneous minimization characterized two terms opposition minimum reached equilibrium contrast dispersion attained show flexibility proposed framework discuss several examples field color perception cognition show adherence theoretical predictions empirical results regard social cognition theories simultaneous occurrence contrast dispersion conflicts sequential models thus supporting idea concurrent presence effects judgment variational framework serve view perceptual cognitive phenomena help deriving new constraints alternative theories elsevier inc rights reserved
exit survey powerful tools allow university obtain information students satisfaction range academic supervision experiences study plans future study used set comprise five main sections section general background section achievement section educational achievement throughout years section career preparation section relationship student study conducted two consecutive sessions semester based findings achievement sessions shows satisfactory result students achieved scales except session next curriculum teaching learning process four years study showed students achieved scales trend also occurs career aspect lowest year later finally relationship student staff revealed lowest score system authors published elsevier ltd
microstructural changes thermodynamic cyclic properties total material cost cumulative energy demand using commercial investigated substitution raises equilibrium hydrogen pressure mpa mpa absorption mpa mpa desorption reversible hydrogen storage capacity determined pressure swing cycles reduced mass mass alloy compared mass mass substituted alloy corresponds loss capacity samples taking account capacity loss caused substitution raw material cost per stored reduced original price alloy cumulative energy demand pure depends number purification steps shows cumulative energy demand reduced least factor compared high purity elsevier rights reserved
janus kinase inhibitor licensed control pruritus associated allergic skin diseases dogs strikingly clinically reported withdrawal leads pruritus dogs therefore primary objective study mimic phenomenon using chronic mouse model allergic contact dermatitis chronic allergic contact dermatitis induced repetitive challenge balb mice orally administered twice daily days concurrent challenge treatment discontinued following challenge evaluated day additionally dorsal root ganglia affected skin isolated mice receiving mice withdrawal used determine induced signals sensory neurons number activated dendritic cells dcs within cytokine profiles affected skin mice treated showed significant decrease treatment following withdrawal significantly increased furthermore following withdrawal neurons activated cytokines tnf alpha positive dcs significantly increased affected skin revealed significant increase tnf alpha conclusion significantly reduced treatment withdrawal led rapid phenomenon explained increase cytokines fast peripheral sensitization
although heterogeneity therapeutic response tnf blockers seems mainly due genetic factors several studies showed range factors influence aim study investigate impact patients demographic clinical characteristics primary response anti tnf therapy psoriatic patients retrospectively examined relationship various clinical demographic features response treatment etanercept adalimumab infliximab evaluated average improvement weeks respectively analyzed data obtained patients better response treatment significantly associated male gender coexistence psoriatic arthritis baseline present study supports clinical factors potential predictors response anti tnf agents psoriatic patients
optical one just subject recently several different approaches proposed demonstrated stealth technology active transformation optics last one formal approach modifying electromagnetic field around object based transformation optics though valid single frequency experimentally demonstrated microwave region operation visible spectrum still distant mainly owing difficulty structure whose elements much smaller wavelength light show optical visible spectrum possible mere principle based geometrical optics combining pair beam right rays light object make observer rays straight two beam observed eventually device simply background image exists
functions nervous system adults widely studied however little known roles embryonic development previous work reported extensive expression receptors adult mouse central nervous system present study examined expression pattern receptor mrna protein prenatal development mouse nervous system embryonic day receptors appeared neural tube early gradually confined new born neurons cortical plate ventral spinal cord heavy signals receptors also found dorsal root ganglia retina olfactory epithelium nerve fibers skeletal muscles conclusion receptors strongly represented developing mouse nervous system transient high expression pattern receptors epithelium like structures suggests role early
although womens representation higher education parity men undergraduate level representation one academic gender gaps elite activity international research collaborations contribute women upper ask gender differences exist participation international collaborations family responsibilities constitute glass gendered obstacle keeps women engagement using international data set find women engage less international collaborations men complex gendered patterns exist regarding impacts partner employment status children men women benefit academic partner although men benefit partner employment status matters children certain family arrangements suggesting former constitutes glass potentially impacting womens access cutting edge international knowledge production elite academic positions
introduction efforts made reduce hiv aids related mortality delivering antiretroviral therapy art treatment however hiv patients resource poor settings still even art treatment study aimed explore factors associated hiv aids related mortality ethiopia method non concurrent retrospective cohort study collected data clinical records adult hiv aids patients initiated art treatment followed january december conducted explore factors associated hiv aids related mortality university specialized hospital survival times time onset art treatment death different characteristics patients retrospectively examined best fit model chosen survival data comparison native semi parametric cox regression parametric survival models exponential log logistic result total hiv patients included study mostly females median age years inter quartile range iqr years estimated follow december accounted person years risk resulted deaths individuals representing median survival time months iqr months overall mortality rate males females survival model best model fitting data lowest main factors associated mortality baseline age years old baseline weight baseline stage low adherence art treatment conclusion effective reduction hiv aids mortality achieved timely art treatment onset maintaining high levels treatment adherence
timely identification treatment osteoporosis following hip fracture recommended mitigate future fracture risk yet prior work demonstrated evidence based recommendations real world implementation sought describe contemporary patterns osteoporosis screening initiation pharmacotherapy following hip fracture based medical pharmacy claims data national sample identified women aged years enrolled private commercial medicare advantage plans prior history osteoporosis diagnosis osteoporosis pharmacotherapy hip fracture experienced hip fracture just women evidence osteoporosis assessment treatment within months fractures respectively women aged years one third less likely utilize recommended services within months compared aged years versus utilization bone mass measurement increased significantly among women aged years study period declining among aged years contrast rates osteoporosis pharmacotherapy remained steady among women aged years yet declined among women aged years aged years respectively accounting differences measured characteristics receipt primary care strongest consistent predictor osteoporosis assessment treatment following fracture american society bone mineral research
article reports analysis studies examining predictive validity implicit association test explicit measures bias wide range criterion measures discrimination meta analysis estimates heterogeneity effects within across domains intergroup bias criterion categories interpersonal behavior person perception policy preference response time brain activity versions stereotype attitude strategies measuring explicit bias feeling multi item explicit measures racism scale hoc measures intergroup attitudes stereotypes criterion scoring methods computed majority minority difference scores relative majority minority ratings minority ratings majority ratings poor predictors every criterion category brain activity performed better simple explicit measures results important implications construct validity competing theories prejudice attitude behavior relations measuring modeling prejudice discrimination
context optical power spectrum data accessible poses posed inverse problem image recovery recently tri linear model proposed imaging leading minimization problem work positivity constraint considered problem solved approximated method paper propose improve approach three fundamental aspects first define estimated image solution regularized minimization problem promoting sparsity fixed using either weighted regularization term secondly solve resultant non convex minimization problem using block coordinate forward backward algorithm algorithm able deal smooth non smooth functions benefits convergence guarantees even non convex context finally generalize model algorithm hyperspectral case promoting joint sparsity prior present simulation results hyperspectral cases validate proposed approach
background healthcare workers risk developing occupational skin disease objectives ascertain causes australian tertiary referral clinic methods retrospective review performed patients assessed occupational dermatology clinic results assessed clinic period years diagnosed common diagnosis contact dermatitis icd followed allergic contact dermatitis natural rubber allergy also relatively frequent major substances causing rubber chemicals mix disulfide formaldehyde formaldehyde hand hard avoid weak allergens caused commercial hand occurred frequently caused alcohol based hand occupational icd mostly caused water wet work hand environmental heat conclusions understanding causes important order develop strategies prevention suggest skin care advice incorporated hand hygiene education use encouraged weak allergens skin substituted accelerator free recommended
recent years support vector regression become emerging popular forecasting technique field machine learning however subjected model selection learning complexity especially massive data set size training dataset number search simultaneously reduce give insight designing effective accurate selection algorithm end paper tries integrate selection training subset model proposes nested particle swarm optimization model selection existing training subset based nested algorithm achieved adaptively periodically estimating search region optimal parameter setting complex involving large scale training data seen extensions yielding nested sequence increasing sample size uniform design idea transplanted modeling process convergence proposed model using two artificial regression problems housing electric load new south empirical data proposed approach compared standard ones existing approaches empirical results show proposed approach select proper training subset parameter also better generalization performance fewer processing time elsevier rights reserved
documented variety species including vertebrates little known model organism insights origin evolution vertebrates identified gene cdna long orf encoding deduced protein amino acids deduced protein terminal signal peptide amino acids activation peptide typical cleavage site domain catalytic asp substrate binding residue asp characteristic recombinant protein able substrate inhibited specific inhibitor soybean inhibitor northern blotting tissue section situ hybridization demonstrated gene expressed tissue specific manner abundant levels hepatic mid gut ovary whole mount situ hybridization showed began express middle third full length primitive gut day larvae hepatic form later development phylogenetic analysis indicated closer vertebrate suggesting continuous evolutionary divergence vertebrate split vertebrate common
within genus among closely related species known differ sexual mode retaining male female system recently evolved self fertility biased sex ratio wild type produce fertile hybrid female progeny progeny either mother viable sterile mother recent study provided evidence suggesting loss regulator allowed produce viable fertile hybrid male progeny males useful variety genetic experiments sought verify result preliminary wild type occasionally produced fertile males confirmed hybrids using rna interference rnai protocol eliminates possibility self progeny found sterile males bearing chromosome fertile males bearing wild type results suggest apparent rescue hybrid viability fertility due incomplete self sperm prior mating
objective aim study evaluate association two haplotype tag single nucleotide polymorphisms snps tgf heart defects methods two polymorphisms tgf gene genotyped polymerase chain reaction restriction fragment length polymorphism pcr rflp patients control association snp tgf found frequency allele patients significantly higher control subjects versus conclusion tgf gene polymorphisms serve novel genetic marker risk
highway bridge longest three two span suspension bridge world investigate seismic performance different connecting configurations deck referred seismic structural systems scale model highway bridge incorporating different seismic structural systems tested tables university shanghai china paper design construction instrumentation loading protocol test model introduced first fundamental frequencies eight bridge models identified compared numerical results damping ratios corresponding fundamental frequencies obtained half power bandwidth method test results show seismic responses three two span suspension bridge seismic loads highly dependent connecting configurations deck relative displacement responses deck longitudinal direction decreased effectively viscous elastic cables addition influences variations viscous elastic cables response model investigated numerical results test results compared good agreement achieved american society civil engineers
ageing central nervous system cns major risk factor alzheimers disease type neurodegeneration associated deficits cognition memory clinically manifested severe dementia numerous mental processes underline cognition including attention producing understanding language learning reasoning problem solving decision making memory formation past parts considered exclusive cellular sites memory cognitive processes however become evident astrocytes major homeostatic glial cell cns provide essential contribution memory formation failure promote cognitive decline response network mechanisms mediated projections located locus astrocytes get excited participate morphological associated synaptic plasticity otherwise thought represent cellular mechanism learning memory morphological plasticity energy demanding process requiring glycogen cns almost exclusively stored astrocytes exhibit cytoplasmic excitability ions second camp ions molecules contribute reception extracellular signals coordinate secretion signalling molecules including peptides participates lipid transport setting astrocytes positioned spatio temporal neural network coordination progression elsevier rights reserved
growing pollution issues research aiming better harvesting solar energy photo catalysts environmental remediation study novel mixed valence state nanoparticles full spectrum responsive photocatalytic activity fabricated via facile route synthesized samples systematically characterized scanning electron microscopy sem transmission electron microscopy tem ray diffraction xrd ray photoelectron spectroscopy xps vis nir diffuse reflection spectroscopy vis nir photocatalytic performance obtained samples investigated degradation methylene blue aqueous solution nanoparticles particle size degrade efficiency light visible light near infrared light exposure respectively furthermore possible photocatalytic mechanism toward near infrared region proposed redox couple played vital parts photocatalytic activity study provides novel full solar spectrum responsive photocatalyst solar light utility environmental remediation elsevier rights reserved
background associated depression anxiety disorders severely adversely affecting quality life functional health status people dearth clinical psychologists embedded services cessation training hearing therapists left meet psychological needs many patients however universally standardized training intervention specifically across whole public healthcare system similar systems elsewhere across world objectives primary aim review components psychological therapies people used tested psychologists inform development standardized delivered psychological intervention secondary aims article identify types psychological therapy people reported tested clinical trial job roles clinicians delivered psychological therapy people literature design authors searched cochrane ear nose disorders group trials register cochrane central register controlled trials pubmed embase cinahl abstracts web science google scholar addition authors searched gray literature including conference abstracts records excluded basis controls used outcomes reached timing setting study design except reviews search results records included psychological therapy intervention reported address adults years related distress restrictive criteria placed upon term records excluded intervention included relaxation necessary parts treatment results total records retrieved retained twenty five themes components included within psychological therapy identified including education evaluation treatment rationale treatment planning problem solving behavioral intervention thought identification thought challenging worry time emotions social comparison interpersonal skills self concept lifestyle advice acceptance mindfulness attention relaxation sleep sound enrichment comorbidity treatment reflection relapse prevention common therapeutic skills frequently reported psychological therapies cognitive behavioral therapy education internet delivered cognitive behavioral therapy records reported delivered psychological therapies context empirical trial role clearly delineated clinicians conclusions review methodology attempt quality evidence synthesize included records research therefore determine relative importance different components psychological therapies perspective patient clinician
investigation paper dimensional nonlinear schrodinger equation ferromagnetic spin chain via symbolic computation hirota method bilinear forms dark one two three soliton solutions derived propagation interaction dark solitons illustrated graphically amplitude shape dark one soliton keep invariant propagation imply transport energy stable dimensional ferromagnetic spin chain asymptotic analysis elastic interactions dark two solitons discussed elastic interaction head interactions dark two solitons displayed amplitudes shapes remain unchanged interaction except certain phase shifts however area interaction amplitudes dark two solitons interaction elastic interaction among dark three solitons interaction among dark two parallel solitons single one presented whose characteristics similar dark two solitons elastic interaction investigated linear stability analysis used analyze modulation instability prove dark solitons stable elsevier ltd rights reserved
positioning regulates access dna binding factors consensus sequences positions determined least part effects dna sequence assembly also moved cis atp dependent remodeling complexes studies used short dna fragments containing single difficult use type template analyze role dna sequence however many remodeling complexes strongly influenced nearby dna ends templates also provide information occurs context chromatin presence flanking limit options protocol describes newly developed method allows mapping positions without remodeling chosen region plasmid template vitro approach uses digestion release protected dna fragments followed restriction enzyme digestion locally unique sites southern blotting provide comprehensive map positions within probe region developed part studies showed human remodeling enzymes tended move away high affinity positioning sequences also differences specificity different remodeling complexes
previous studies suggested perfusion abnormalities parkinsons disease driven dementia study aimed identify perfusion underpinning cognitive alteration non patients cerebral blood flow measured using arterial spin labelling patients age years age matched healthy controls age years also underwent neurological cognitive testing weighted scans patients analysed voxel wise manner using software associations values volumes interest behavioural cognitive measures assessed spearman correlation analysis posterior cortical found patients compared left gyrus superior temporal gyrus left posterior cingulate precuneus positive correlation revealed perfusion cognitive examination revised ace scores filtering effect age equivalent dose led total intracranial volume conversely negative correlation ace detected effects motor impairment age led non subjects blood flow abnormalities precuneus posterior cingulate linked level motor impairment global cognitive performance perfusion abnormalities gyrus serve compensatory mechanism brain degeneration decreased cognitive performance
dynamics population undergoing selection central topic evolutionary biology question particularly intriguing case selective forces act opposing directions two population scales example fast replicating virus strain slower replicating strains within host scale however fast replicating strain causes host morbidity less frequently transmitted slower replicating strains host scale consider stochastic ball process models type phenomenon prove weak convergence process two natural first scaling leads deterministic nonlinear partial differential equation interval dependence single parameter lambda show fixed points differential equation beta distributions stability depends lambda behavior initial data around second scaling leads measure valued process infinite dimensional stochastic process frequently associated population genetics
paper presents comprehensive sensitivity analysis typical public housing development hong kong based combined building energy daylight airflow network simulation generic building model constructed proposed mixed mode ventilation control strategy fulfill thermal comfort requirement local green building guidance numerical modeling results used conduct local global sensitivity analyses determine relative importance major passive design parameters comprehensively cover design aspects building layout building geometry infiltration air calculated global local sensitivity indices cooling energy prove window solar heat gain coefficient window ground ratio external obstruction projection fraction four influential passive design factors similar results also obtained lighting energy specified output sensitivity analysis optimized building model derived sensitivity analysis anticipated achieve energy saving compared baseline model local building regulation believed sensitivity analysis useful identifying crucial design parameters facilitate optimization building performance early architectural design stages elsevier ltd rights reserved
introduction perception direct gaze another individuals gaze directed observer leads eye contact known influence wide range cognitive processes behaviors stress effects mainly reflect positive impacts human cognition thus used relevant tools therapeutic purposes objectives review aim provide exhaustive review eye contact effects discussing limits dominant models used explain effects illustrate therapeutic potential eye contact targeting pathologies show preserved gaze processing deficits one several functions targeted eye contact effects propose concrete ways eye contact employed therapeutic tool discussion variety eye contact effects four categories including memory effects activation prosocial behavior positive self others enhancement self awareness emphasize models proposed account effects poor predictive value descriptions effects needed emphasize people pathologies affect memory social behavior self appraisal self awareness benefit eye contact effects focus depression autism alzheimers disease illustrate proposal knowledge anomaly eye contact reported depression patients suffering alzheimer disease early moderate stage shown maintain normal amount eye contact take account autism controversial regarding whether gaze processing preserved altered first view individuals thought eyes second individuals considered able process gaze others adopt first stance following view people autism interested processing social signals gaze efficiently properly motivated pathology emphasize eye contact used example enhance sensitivity bodily states thus improving emotional decision making autism lead positive appraisal self others depression improve memory performances alzheimer disease generally motivate recipient engage therapeutic process finally propose two concrete ways employ eye contact effects therapeutic tool first develop cognitive behavioral tools learn motivate recipient create frequent prolonged eye contact periods second raise awareness among caregivers beneficial effects eye contact teach way use eye contact reach optimum effects future investigations however needed explore ways eye contact effects efficiently integrated therapeutic strategies identify clinical populations benefit therapeutic interventions paris
objective identify predictors delayed recovery children sustained sought care pediatric hospital design retrospective cohort study design setting childrens hospital clinic database patients children sustained sought care within days injury complete medical history symptom scale score available independent variables total symptom score sex age history sleep disturbances anxiety learning disabilities attention problems depression main outcome measure delayed recovery days results total children mean age years included total score days identified significant predictor delayed recovery odds ratio conclusions study demonstrates potential clinicians identify sole use children risk experiencing symptoms longer periods time
neural basis autism spectrum disorder asd yet understood asd marked social deficits strongly associated cerebellar abnormalities studied organization cerebellar connectivity junction area plays crucial role social cognition applied localized independent component analysis resting state fmri data autistic adolescents yield unbiased bilateral independent components ics comparison autistic adolescents showed organization significantly altered asd second used time courses ics spatially unbiased seeds functional connectivity analysis applied within cerebellum found cerebellum contained fine grained map connectivity cerebellar zones showed one striking difference asd right dorsal showed markedly less connectivity left disturbed cerebellar input key region cognition multimodal integration contribute social deficits asd findings also suggest right left potential targets noninvasive brain stimulation therapies
paper presents new curvature compensated cmos reference topology high power supply reject ratio dual differential input amplifier used generate complementary absolute temperature voltage voltage used fine tune curvature compensation experimental characterization reference circuit implemented cmos process yielded reference voltage temperature coefficient ppm degrees across temperature range degrees also realized high output load current driving ability without use external buffer amplifier
acetylcholinesterase inhibitors regarded promising therapeutic agents treat addiction current study aimed examine effects inhibitor behavioral sensitization induced repeated administration relapse induced contextual conditioning present study also assessed whether state dependency hypothesis explain results adult rats divided four groups injected saline control days effect repeated administration alone locomotor activity assessed experiments analyzed development induced sensitization rats divided five groups saline saline saline following withdrawal period days animals administered saline appropriate test state dependency hypothesis rats saline group injected saline three groups administered different doses examine effect expression induced sensitization rats groups injected appropriate concentrations current results indicated administration alone affect locomotor activity higher doses inhibited addictive behavior induced development phase additionally administration expression phase sensitization inhibit relapse induced administration saline furthermore inhibited expression induced behavioral sensitization therefore results current study support state dependency hypothesis
background early age occurrence common eye malignancy childhood suggests perinatal factors contribute etiology methods large multicenter study non familial conducted structured interviews parents cases controls elicit information health perinatal period used logistic regression assess associations parental fertility treatment birth control use year prior pregnancy maternal health conditions use prescription medications pregnancy whether mothers index child results bilateral related maternal body mass index prior pregnancy odds ratio confidence interval regards unilateral observed negative association use condoms year prior pregnancy trend towards positive association maternal diabetes conclusions results study suggest role several maternal health reproductive factors given epidemiologic studies results require replication studies utilize medical record review
need development new drugs prevent osteoporosis related fractures fractures projected increase present drugs modest efficacy significant side effects poor compliance illustrate difficulties development new drugs author reviews fate several drugs failed gain regulatory approval drugs include new drugs presently phase development anticipated ongoing studies mechanisms signaling pathways involved regulation bone remodeling open new opportunities targeted pharmacological interventions increase bone strength however perfect drug still long way face many obstacles approval
propensity delay measured rate associated variety positive outcomes including higher rates education savings lower rates poverty addiction significant literature supports linkage religion self regulation use online experimental approach test influence religious salience rates experiment used real hypothetical rewards design using large sample able test impact religious across variety religious non religious contrary previous studies find evidence increased religious salience increases observed rates furthermore find significant difference impact religious salience across religious groups elsevier inc rights reserved
study investigated moderators intervention response fully automated internet based monitoring feedback intervention different levels therapist support individuals eating disorder symptoms study part randomized controlled trial comparing four conditions low intensity weekly therapist support high intensity three times week therapist support waiting list total participants completed baseline post intervention assessments outcome measure psychopathology model based recursive partitioning applied baseline levels psychopathology found moderate intervention response specifically terms improvement symptoms anorexia nervosa participants higher baseline levels psychopathology showed better outcomes waiting list condition conditions low high intensity therapist support comparison without therapist support terms improvement symptoms bulimia nervosa participants mild moderate symptoms better outcomes conditions compared waiting list thus fully automated internet based intervention without therapist support particularly suitable improving mild moderate psychopathology whereas intervention without therapist support less effective improving severe psychopathology investigating differential intervention responses important help optimize delivery dissemination health interventions therapist support turn help moving toward personalized care elsevier ltd rights reserved
paper provides brief introduction theory comprehensive theory understanding hard maintain behaviour change name context executive operational systems theory behaviour result moment moment interaction internal needs operational processes relation environmental conditions humans augmented goal directed executive action immediate behaviour generated operational processes goal directed behaviours contingency generated competing behaviours operational processes sufficiently activated support affective force generated around executive system goals things memories direct experience experience emotionally charged communications mediated stories person generates paper makes theory particularly around role feelings importance stories scripts facilitating executive action also range issues relevant behaviour change provides framework understanding limitations informational environmental approaches behaviour change need self regulatory strategies taking account basic aspects human functioning
background gluten related disorders term encompasses different diseases induced ingestion gluten containing food incidence scientific community intensively studying aim support correct diagnostic approach gluten related disorders adulthood methods italian association hospital panel experts prepare position statement diagnosis gluten related disorders focusing interest member assigned task levels evidence recommendation proposed results panel identified celiac disease wheat allergy non celiac gluten sensitivity gluten related disorders interest celiac disease autoimmune nature wheat allergy ige mediated pathogenesis non celiac gluten sensitivity still unknown case non ige mediated allergy diagnosis start serological screening celiac disease wheat allergy case normal values response gluten free diet evaluated confirmatory blind food challenge carried conclusions gluten related disorders clinically heterogeneous patients carefully managed specific protocols applied correct differential diagnosis setting published elsevier ltd rights reserved
product process platforms promoted possible increased productivity civil engineering however platforms traditionally applied mass manufacturing industries production assets employed continuous production uniform products strongly facilitates continuous improvement discontinuous nature project based production civil engineering possibilities thus platforms implemented need methods capable evaluating performance integrated product production process configurations specific projects possibility explored paper use database driven simulation case study configurable simulation model based standardized process patterns values stored platform developed production bridge concept presented results provide evidence database driven simulation support efficient platform evaluation development integrating product process information even discontinuous project based industrial sectors results specifically demonstrate approach used evaluate effects different configurations construction methods working time requirements without time consuming updates models
child health literacy hot topic late researchers practitioners work attain healthy future health literacy emphasizes wide range skills people need access understand evaluate use health information promote good health light recognition health literacy important determinant health adults addressing child health literacy early essential maximize future health outcomes meeting childrens specific needs arguably includes delivery information easily accessed understood younger age groups much academic discourse importance building parental health literacy less literature explicitly focuses child centred health literacy premise health literacy asset paper provides argument childrens health literacy working children encourage meaningful contributions research practice
background side effects prescribed use understudied objectives study examined side effects prescribed use college sample attention possible gender differences methods undergraduates male ages years years years completed online survey included questions subjective side effects prescribed use results results suggested prescribed users frequently reported side effects compared users prescribed users females frequently reported appetite somatic anxiety related side effects compared males users females reported somatic anxiety related side effects males frequently reported loss sex drive side effects conclusions importance findings suggest prescribed users frequently report side effects prominent gender differences line gender roles
context children living high risk published reviews existing interventions promoting better nutrition children living risk factors childrens malnutrition improved understanding risk factors malnutrition communities impact interventions childrens health provide guidance practitioners decision makers present review designed provide information methods search included electronic databases relevant eligible studies published december results search located citations full text relevance screening conducted studies abstracts studies final unique studies included interventions risk interventions nutrition specific nutritional intervention dominant type seventy three per cent interventions assessed effective conclusion findings stressed gaps knowledge terms quality assessment recommendations identify children risk malnutrition appropriately target interventions finally review helped inform systematic review cochrane systematic review protocol examine impact interventions outcome measures
paper one new parallel version method method brief proposed solving large sparse linear systems coefficient matrices distributed parallel environments method reduces three global synchronization points one method communication time required inner product efficiently overlapped computation time vector updates combines elements numerical stability characteristics design parallel algorithms cost slightly increased computation time ignored compared reduction communication time performance analysis shows method better parallelism scalability method numerical experiments show scalability improved factor improvement parallel communication performance approaches
phase change materials high thermal conductivity efficient solar energy conversion recently attracted much attention however facile strategy enhance thermal conductivity realize energy conversion storage still desired work low content graphene nano platelets introduced poly ethylene glycol peg composite resulting great improvement thermal conductivity ability via facile solution blending process presence contributes enhancing thermal conductivity realizing efficient solar energy conversion including solar thermal solar electric energy conversion peg composite owing formation improved thermally conductive network improvement sunlight harvesting ability respectively properties demonstrate compared peg composite content peg composite containing low content maintain comparable energy storage density study sheds light realization solar energy utilization storage organic requiring high thermal conductivity elsevier rights reserved
acute intermittent autosomal dominant disorder caused partial deficiency third enzyme heme biosynthetic pathway affect autonomic peripheral central nervous system posterior reversible syndrome entity characterized headache seizures altered consciousness visual disorder associated potentially reversible abnormalities predominantly occipital lobes establishing accurate diagnoses patient asymptomatic family members involves identifying enzyme mutations directly study report year old woman acute intermittent presented radiological manifestations suggestive posterior reversible syndrome novel frame shift mutation base resulting stop codon chinese family elsevier inc rights reserved
heavy metal migration evaluated covered different constructions four constructions different one direct second two geotextile layers set third also two geotextile layers fourth clay two geotextile layers evaluated day laboratory column experiments year field cover application pond northeastern china contents soils leaves analysed coupled plasma optical emission spectroscopy results showed values columns increased time range maximum appeared day respectively effectively reduced concentrations addition enhanced efficiency especially concentrations directly cover less initial concentrations resulting presence reduced mobility clay effective preventing migration less impact year field experiment values increased slightly time range end experiment concentrations plots showed little change compared initial value acid soluble concentrations upper soil increased indicating acid soluble heavy metals acid soluble showed small increase plot indicating migrate clay layer pore water contents leaves lower contents leaves higher reliable technique preventing toxic elements moving downward upward ecological restoration ponds elsevier rights reserved
present vision system design landing unmanned aerial vehicle flight deck autonomously edge information international landing target used perform line segment detection feature point mapping clustering cascade filtering scheme applied target recognition meanwhile pose vehicle respect target estimated vision system implemented conjunction state estimator perform real time target recognition tracking controller designed close control loop experiments show vision system accurate robust capable dealing incomplete landing target whilst overall implementation shows real time target tracking closed loop control
widespread dissemination smart mobile devices offers new perspectives timely data collection large scale scenarios however realizing sophisticated mobile data collection applications raises various technical issues like support different mobile operating systems platform specific features often specifically tailored mobile applications implemented order meet particular requirements context changes data collection procedure become costly profound programming skills needed adapt respective mobile application accordingly remedy drawback developed model driven approach enabling end users create mobile data collection applications basis approach elements flexibly defining sophisticated questionnaires called instruments contain information data collected also instrument processed different mobile operating systems latter purpose provide advanced mobile kernel service capable processing logic sophisticated instruments various platforms paper discusses fundamental requirements kernel introduces generic architecture feasibility architecture demonstrated prototypical implementation altogether mobile service allows effective use smart mobile devices multitude different data collection application scenarios clinical psychological trials
purpose injuries occur frequently many accident survivors suffer temporary permanent disabilities although accident victims recover quickly significant fraction shows complicated recovery process accounts majority disability costs thus early identification vulnerable persons beneficial compensation schemes government bodies worker present work health questionnaire screening tool already implemented case management process swiss accident insurance moreover demonstrate prognostic value identifying workers risk complicated recovery process methods total injured workers answered within first months accident minor moderate accidental injuries severely injured workers excluded analyses individual level data extracted insurance databases examined construct validity factorial analyses prognostic validity hierarchical multiple regression analyses days work disability evaluated job satisfaction months post injury subsample injured workers results factor analyses supported five underlying factors job design work support job strain somatic condition pain anxiety subscales moderately correlated thus indicating different subscales measured different aspects work health related risk factors injured workers item analysis reliability analysis showed accurate psychometric properties subscale predictive least one evaluated outcomes months post injury conclusion shows good psychometric qualities high clinical utility identify injured persons multiple psychosocial risk factors thus questionnaire appears suitable exploring different rehabilitation needs among minor moderate injured workers
aim study determine frequency styles connection job satisfaction satisfaction extrinsic intrinsic aspects work teachers sample included secondary school teachers three three vocational schools three results indicate prominent styles star star attached greater significance intrinsic aspects work reported higher job satisfaction rate placed importance extrinsic ones independent thinking correlated intrinsic aspects work job satisfaction active participation job satisfaction work aspects results also show higher degree engagement particularly combined economic satisfaction predicted higher level job satisfaction dominant motivational structures teachers management educational institutions improved teachers participate making work decisions greater sense empowerment commitment organizational goals although affected types personality dominant structures teacher influenced course professional training thereby directing towards development functional types
report deals problem design new generation aircraft technical state monitoring systems using methods artificial key point intellectual support theory system identification applied problem aerodynamic parameter estimation flight data report considers specific aspects parameter identification problem part real time intelligent monitoring system aircraft model object noise identification algorithm estimation identification accuracy formulated presented algorithms tested processing data generated using modern aircraft simulation facility authors published elsevier
absence abnormalities noninvasive cardiac assessment possibly confers reduced risk atrial fibrillation despite presence traditional risk factors findings noninvasive cardiac assessment associated lower risk development methodswe examined clinical utility normal findings routine noninvasive cardiac assessment participants white women cardiovascular health study free baseline combination normal ecg normal assessed development events normal ecg defined absence major minor code abnormalities normal defined absence contractile dysfunction wall motion abnormalities abnormal left ventricular mass cox regression used compute year risk developing year study period total events detected normal ecg multivariable hazard ratio confidence interval normal multivariable associated reduced risk isolation association improved normal ecg normal multivariable compared participants abnormal ecg abnormal findings routine noninvasive cardiac assessment identify persons risk low studies needed explore utility profile regarding decision implement certain risk factor modification strategies older adults reduce burden
large number studies conducted economic psychology cognitive sciences behavioural support idea economic actions result rational utility behaviour seem driven factors personality traits psychological factors gender age genetic heritage context capital markets sometimes non efficient anomaly based trading strategy used enhance returns especially case emergent markets article analyses presence seasonal affective disorder sad effect stock market time span includes growth periods volatile periods one global financial crisis results support existence correlation number hours daylight market returns last financial crisis even effect seems change crisis
introduction gastroesophageal adenocarcinoma frequently occurring cancer worldwide poor clinical outcome gastroesophageal junction shown recent increase frequency therefore need increase understanding order improve ability detect monitor treat covered authors discuss current classification context recent changes incidence authors also discuss developments understanding disease biology recent discoveries whole genome whole exome sequencing studies immunotherapy finally authors discuss recent developments use circulating tumour dna pubmed search terms english including esophageal gastric adenocarcinoma gastroesophageal tumour whole genome exome sequencing immunotherapy circulating tumour commentary shared biological genetic changes suggest investigated single disease entity different molecular subtypes number genes mutated including frequent somatic copy number alterations high levels chromosomal instability subset genetic alterations detected provide important avenue research detecting minimal residual disease response
objective work improve drying respect quality drying slices studied hot air drying hybrid hot air infrared drying degrees air velocity thickness using full factorial design shrinkage color changes slices monitored real time computer vision system drying treatments ranked based function using combination minimal color change minimal shrinkage drying time decision criteria proper conditions drying determined average linkage method clustering temperature degrees thickness air velocity finally hybrid approach first stage second stage drying proposed reasonable compromise drying time product quality
background migraine prevention guidelines recommend oral prophylactic medications patients frequent headache study examined oral migraine preventive medication treatment patterns evaluating medication persistence switching initiation patients chronic migraine methods retrospective claims analysis health databases evaluated patients years old diagnosed initiated january september treatment persistence measured six months follow time discontinuation assessed compared using cox regression models among discontinued proportion switched within days initiated treatment days associated persistence rates also assessed results total patients met inclusion exclusion criteria persistence initial six months months based kaplan meier curves sharp decline patients observed days approximately half discontinued days similar trends time discontinuation seen following second third significantly higher likelihood non persistence compared among patients discontinued switched another prophylactic initiated therapy within one year among patients switched persistence among initiated patients persistence months conclusions persistence poor six months declines months switching common results indicate persistence patients cycle various
background compared ischemic stroke sex differences response hemorrhage largely unexplored potential interactions patient age examined study hypothesized risk poor outcome greater women increasing age methods results get guidelines stroke database used assess differences men women data patients admitted january march fully participating sites analyzed using logistic regression test interactions age sex outcome results total study population women median age male median age admission women years less likely atrial fibrillation dyslipidemia use antiplatelet therapy cholesterol likely suffer worse neurological deficit men age increased odds hospital mortality increased men women although relationship stronger men odds combined mortality discharge similar men women increasing age odds discharge home independent discharge decreased women increasing age conclusions adjusting covariates modest sex differences early outcomes linked age statistically significant detected interactions considered context future study examine whether sex based interactions represent biologic treatment differences covariates combination thereof
chronic obstructive pulmonary disease copd common worldwide predominant cause copd environmental exposure inflammatory processes copd multifactorial complex interacting leading many potential therapeutic targets although typically associated inflammation type now known copd also associated eosinophilic inflammation type particularly exacerbations accordingly active program investigation highly selective biologic therapeutic agents management copd review summarizes clinical trials use novel agents management copd
satisfy demand multilayer films polarization detection polarized bidirectional reflectance distribution function multilayer films slightly rough substrate established basis first order vector perturbation theory polarization transfer matrix due function light scattering polarization properties studied multi factor impacts two typical targets monolayer anti reflection film multilayer high reflection films result shows monolayer anti reflection film observing positions great influence degree polarization left peak increased right decreased compared substrate target film target bare substrate distinguished degree polarization different observation angles multilayer high reflection films degree polarization significantly associated number optical thickness layers different wavelengths incident light scattering angles increase layer number degree polarization near mirror reflection area decreases reveals calculated results experimental data correctness model paper provides theoretical method polarization detection multilayer films target reflection stealth technology
background one largest plant families distributed worldwide grass pollen allergy one important pollen allergies affecting large parts population worldwide grass pollen season special since caused various grass species present unique profiles plays significant role impact grass pollen sensitization profiles allergy aim study conducted analyze possible contribution prevalent grass species grass pollen season symptom load grass allergy methods first study combines observations grass species periods measurements daily grass pollen concentrations allergic symptoms local users patients diary symptom load index calculation results pollen concentrations symptom levels higher first half main grass pollen season therefore show highest impact pollen allergy important note following species widely distributed grass false grass grass grass conclusion monitoring different grass species provided evidence varying contribution across main grass pollen season highlighted significance impact pollen allergy elsevier rights reserved
solar power become attractive alternative source energy multi crystalline solar cell widely accepted market relatively low manufacturing cost multi crystalline solar larger grain sizes fewer grain boundaries higher quality convert energy efficiently mono crystalline solar cells article new image processing method proposed assessing quality adaptive segmentation algorithm based region growing developed separate closed regions individual grains using proposed method shape size grain image precisely evaluated two measures average grain size taken literature modified estimate average grain size resulting average grain size estimate quality crystalline solar considered viable quantitative indicator conversion efficiency
associated fungi dispersed flower heads possibly birds fungus vectors offer regular dispersal distant hosts unlike occupies multiple host species study aimed determine whether shares long distance dispersal pattern specialist whether moves freely different host species evaluated genetic structure five populations wide spread host hosts twelve specific microsatellite markers developed applied individuals showed high genetic diversity almost maximal genotypic diversity populations poorly differentiated indicating presence long distance dispersal differentiation detected host populations suggesting free dispersal different hosts implies vectors species show non specific movement elsevier ltd british society rights reserved
variety methods developed measure soil biological activity methods suited produce generally accepted results give relative information ecological status soil soil enzymatic activity assays one way measure ecosystem status soils technique quite simple produces reproducible results nowadays practical importance influence chemicals industrial waste heavy metals soil fertility management measured especially search inhibitor particular interest order reduce ammonia losses soils soil enzymes reported useful soil quality indicators due relationship soil biology practical sensitive integrative ease measure described biological past soil management relate soil structure focus article provide review soil enzyme activity biological process level indicator impacts natural anthropogenic activities soils knowledge soil enzymology applicable human ecosystem perturbation agricultural practices pollution
introduction alzheimer disease common form dementia incidence increasing rate world pathophysiology characterized chronic progressive neurodegeneration involves early one obvious pathological feature accumulation amyloid brain since current treatment options provide symptomatic help thought underlie early synaptic pathology reduction modulation brain promising therapeutic strategy preventing reversing related covered paper outlines evaluates current landscape preclinical clinical studies focusing modulating pathophysiology data analysis review pubmed opinion according current knowledge reducing production offers numerous treatment options however targeting initial steps pharmacological interference challenging due emergence various side effects promising approach seems prevention early combination approaches targeting tau seem another promising strategy beneficial effects course disease
invasive fungal infections considerable cause morbidity mortality increased hospital stay durations high health care costs neonatal period period premature infants affected candida species leading cause invasive fungal infections majority neonatal candida infections caused albicans although fungus species reported one emerging pathogen organism reported pathogen neonatal period principally premature infants risk factors associated fungal infection central line immunosuppression prolonged hospital stay exposure antibiotics present term baby mass required several procedures central mechanical ventilation antibiotics evolution presented infection baby treated amphotericin satisfactory clinical course
last decade number available cores increased heterogeneity grew work ask question whether design current operating systems still appropriate trends continue lead abundantly available heterogeneous cores whether forces fundamental systems designed argue heterogeneity behind common hardware interface large extent control coordination cores network chip rather processor features like mode memory management unit allows running code arbitrary cores providing services via protocols network instead via system calls makes accessible arbitrary types cores summary turns first class citizens enables single convenient programming environment cores without need trust application paper introduce network chip level isolation present design based common hardware interface evaluate performance prototype comparison linux bit surprising without using outperforms linux application level benchmarks factor five
system identification engineering technique used build mathematical models dynamic systems observed data neuroscience research system identification used adapt robotic devices measurements apply perturbations techniques shown useful tools investigate brain mechanisms motor learning processes motor dysfunctions paper reviews application system identification motor behavioural data pertaining interruption specific neural mechanisms system identification technique reveal adaptation functions neural mechanisms motor tasks fit experimental data measured robotic devices discrete state space model comparing constructed models persons neurological disabilities healthy control subjects system identification used identify impaired abilities furthermore recent study indicated discrete state space model predict recovery motor function stroke therefore suggest marriage robotic devices system identification comprise novel approach clinical assessment aid design patient rehabilitation protocols
objective study evaluated efficacy targeted social skills training group school aged children autism spectrum disorder asd intervention nonverbal communication emotion recognition theory mind training session cognitive behavioral intervention verbal school aged children targeting asd specific social behavioral impairments method sixty nine children asd years age verbal greater participated randomized comparative trial examine efficacy relative facilitated play group treatment outcomes included caregiver reports social behavior neuropsychological assessments social cognition conducted blinded raters outcomes collected baseline endpoint months posttreatment results significant improvements found social behavior outcomes nonverbal communication empathic responding social relations condition relative active control endpoint verbal moderated interaction effect social behavior higher verbal associated improvements condition significant improvements found social cognitive outcomes significant group differences found month follow conducted approximately half sample conclusion data indicate targeted social skills groups improve social communication deficits verbal school aged children asd moderating effects high verbal suggest need consider participant treatment characteristics associated outcomes future studies
glass widespread everyday objects around high specialized devices among different technologies gel synthesis allows nanoscale materials engineering exploiting unique structures transparent glass ceramics tailor optical electromagnetic properties boost photon management yield briefly discuss state technology show choice gel synthesis method brings advantage process versatility regarding materials composition ease implementation context present tin dioxide silica glass ceramic activated ions focus properties system properties already discussed papers presented main findings include high gel glass ceramic ultraviolet induced index change delta similar easy fabrication process low propagation losses make glass ceramic interesting photonic material smart optical applications
studies described metabolism logic analysis cough phenyl human urine using gas chromatography mass spectrometry studies showed metabolized humans mainly aromatic ring parent drug hydroxyl metabolite corresponding degradation moiety authors systematic analysis procedure using full scan acid hydrolysis liquid liquid extraction microwave assisted acetylation allowed detection mentioned metabolites human urine hours intake single common therapeutic dose target analytes found parent compound earlier phase excretion metabolite para hydroxy later phase excretion allowed detection intake also differentiation derivatives
system implements encrypted query processing support complex queries fine grained access control create update read operations data stored database server public cloud past research efforts adequately addressed flexible access control encrypted data different granularity levels critical data sharing among different users applications proposes novel technique fine grained access control encrypted query processing evaluating sql queries encrypted data fine grained access control granularity level column row cell based expressive attribute based group key encryption scheme require modifications database engine thus maximizes reuse existing infrastructures experiments evaluate performance encrypted database managed using queries benchmark comparison plain text evaluate functionality prototype using policy simulator multi user web application results show efficient scalable large datasets
computer programming offered universities intended prepare provide undergraduate students technical knowledge essential skills work real life software projects unfortunately developing countries programming hard faced insufficient infrastructures teaching spite challenges undergraduate students never back increasingly developing software applications improving skills even without formal classes software intended use developer requires teamwork application software engineering methodology therefore concern learn programming development methodology apply ensure product quality paper investigates learn programming knowledge software quality conducted survey undergraduate students computer science university developers data collected analyzed qualitatively presented results show students consider online reuse codes new best method learn programming furthermore used development methodology software quality
paper presents model based control solution large inertia systems controlled fast digital hydraulic valve solution based model based force control shown cylinder chamber pressures first order dynamics proper parameter selection robust stability analyzed unknown load mass bulk modulus delay shown simple cascaded pid controller results good control performance robustness simulated results show smooth stable response good tracking performance despite large variations load mass bulk modulus
nowadays low cost implement cryptographic primitives order support practical applications effective implementations side channel attacks especially differential power analysis attack still active topic embedded device security low cost lack many features true random number generators typically used modern countermeasures hand currently even low cost contain several program flash memory always completely used target paper propose new attack use randomly assigned general constant weight codes codes every intermediate value secure embedded device ideal hardware equal weight data ensures balanced power consumption values device thus attack demonstrate method table based aes cipher propose several implementation enhancements reduce size tables suitable practical implementations evaluate performance proposed method terms speed memory usage test possible side channel system implemented arm cortex elsevier rights reserved
current study designed investigate properties water absorption capacity stimuli ethanol saline responsive swelling switching controlled drug release isolated seeds water retention capacity hydrogel found hydrogel also exhibited swelling water basic insignificant swelling acidic buffer swelling kinetics follows second order moreover salt solutions ethanol sem dried revealed channels average diameter furthermore sustained release tablet formulation drug release mechanism ascertained super case transport results smart material sustained release formulations elsevier rights reserved
multitude contemporary applications now involve graph data whose size continuously grows trend shows signs caused emergence many distributed graph processing systems including pre gel apache however unprecedented scale now reached real world graphs task graph processing even distributed environments current memory usage patterns rapidly become primary concern contemporary graph processing systems seek address challenge exploiting empirically observed properties demonstrated graphs generated human activity paper propose three space efficient list representations applied distributed graph processing system suggested compact representations reduce respective memory requirements graph elements times compared state art methods time memory optimized methods retain efficiency structures enable execution algorithms large scale graphs settings contemporary alternative structures fail due memory errors
global climate environment deterioration getting worse phenomenon wind sand flow frequently occurs many areas suspension bridges suffer impact wind sand flow damaged study type four commonly used long span suspension bridges taken example investigate influence wind sand flow aerodynamic interference effect occur among four action wind sand flow order explore influence wind sand flow wind sand flow field around type long span suspension bridge simulated within software basis numerical simulation computational fluid dynamics pressure velocity contour coefficients forces produced wind sand flow different wind attack angle volume fractions sand phase analyzed simulation results indicate forces exerted wind sand flow type greater forces exerted wind wind wind sand flow field drag lift coefficients front two exhibit minor changes increasing wind attack angle whereas back two increase first decrease small value volume fraction sand phase insignificant effect drag lift coefficients significant effect force exerted force exerted volume fraction sand phase results lay theoretical foundation corrosion fatigue analysis type large span suspension bridges action wind sand flow
stress early life important phenomenon onset depression poor response treatment classical antidepressants furthermore childhood trauma triggers epigenetic changes associated pathophysiology major depressive disorder mdd treatment atypical antipsychotics exerts therapeutic effect mdd patients induces epigenetic changes study aimed analyze effect chronic treatment depressive like behavior rats submitted maternal deprivation activity histone acetylation enzymes histone acetyl dna methylation dna methyltransferase enzyme prefrontal cortex pfc nucleus hippocampus deprived rats depressive like behavior forced swimming test increase activities hippocampus treatment reversed depressive like behavior reduced activity hippocampus first study show antidepressant like effect animals subjected protective effect reducing epigenetic changes induced stress early life results reinforce important role therapy mdd elsevier rights reserved
chapter control design approach based linear parameter varying systems exploited solve several problems typically encountered control engineering presented means recent techniques based shown possible design optimize stabilizing controllers also exploit structure controller face solve side problems including dealing nonlinearities taking account control input constraints performing controller online adaptation presence faults dealing delays system control scheme observer based namely observer based applied consequently parameter applied produce supplementary input ignition function residual value difference output estimated output based fact stable operator maps residual supplementary input preserves stability several additional features added compensator without compromising loop stability
family structure risk child maltreatment long viewed static state child maltreatment literature drawing data fragile families child wellbeing study author uses series individual fixed effects models investigate whether particular types relationship transitions childrens first decade life associated increased risk maternal paternal child abuse maternal neglect findings question confirm number long standing theoretical empirical findings child maltreatment literature results indicate transitions single associated increased risk maternal child abuse neglect addition frequency severity paternal harsh parenting closely linked nature fathers relationship transitions last results largely provide support theory presence social fathers increases mothers risk engaging child abuse neglect
paper establishes capacity region class source coding function computation sources information available nodes tree function sources computed root capacity region holds function long sources joint distribution satisfies certain markov criterion criterion met particular sources independent result capacity regions several function computation include point point communication setting arbitrary sources multiple access network independent sources cascade network sources
study examined impact extract viability enzyme activity lactobacillus storage presence significantly enhanced viability strains exhibited better stability showed highest viability samples containing followed control samples results suggest used natural additive dairy products improve growth viability strains
closed loop geometry based optimization method developed work integrating metaheuristic searching techniques purpose surfaces using triangle meshes simultaneously applied cad computer aided design modeling computer aided engineering analysis framework feature objects defined model models controlled geometric parameters global optimization metaheuristic algorithms performed independent coefficients method introduced enhance efficiency optimization order improve accuracy triangular meshes fem edge based finite element method technique employed analysis work proposed approach successfully tested three real engineering geometry optimization problems elsevier ltd rights reserved
paper presents use new element designing based controllers port description electrical circuits target dynamics assigned matching equation proposed methodology known interconnection damping assignment based control inclusion element extends closed loop dynamics results extra term control algorithm seen state modulated gain two mechanical examples form position control systems included show possible applications european control association published elsevier ltd rights reserved
discovering relations face images wild become interesting important problem multimedia computer vision despite rapid advances face analysis environment verification still remains challenging problem subtle relation difficult discover changes pose lighting condition complicate task paper propose verification approach based multi linear coherent space learning local image patches different scales independently projected corresponding coherent spaces learned robust canonical correlation analysis patch pairs relations improved correlation addition discriminative patches verification selected via constrained linear programming experimental results two widely used verification datasets show proposed method effectively identify different relations image pairs compared state art techniques proposed method achieves competitive performance use simple feature descriptors
autophagy highly conserved process whereby unwanted cytoplasmic contents double membrane delivered degradation responsible recycling nutrients cellular components thus playing pivotal role maintaining cellular homeostasis cell survival stress conditions perturbations autophagy implicated multiple diseases cancers neuro degeneration diseases recent studies demonstrate autophagy participate almost every step immune responses including pathogen recognition antigen processing presentation immune cell development function pathogenesis autoimmune diseases multiple sclerosis crohns disease reported associated dysregulated autophagy systemic lupus erythematosus sle chronic potentially fatal autoimmune disease characterized dysregulation immune cells production autoantibodies cause widespread tissue organ damage pathogenesis sle remains unclear several single nucleotide polymorphisms snps autophagy related linked sle susceptibility lines evidence animal model cell biology immunology genetics studies show autophagy contributes occurrence development severity sle elsevier rights reserved
theoretical knowledge theoretically oriented study materials always great advantage education universities however access learning materials know used industrial practice limited regard issue faculty mechanical engineering university west launched project example projects practice worked outputs projects learning files study materials contain important information designer normally comes contact practice interactive models processes welding machining assembly one projects focused press used closer examination developed study materials authors published elsevier ltd
deep transcranial magnetic stimulation relatively new technique uses different coils treatment different coils made soft copper windings multiple planes lie adjacent skull located within special magnetic fields combine improve depth penetration coil designed stimulate bilateral prefrontal cortices greater effective stimulation left right positioning left side coil close left dorsolateral prefrontal cortex coil used study leading fda approval treatment resistant depression position coil also explored possible treatment negative symptoms schizophrenia bipolar depression migraine moved different positions subjects skull coil also explored possible treatment conditions manipulation coil demonstrated ptsd alcohol dependence positioning medial prefrontal cortex anxiety positioning right prefrontal cortex auditory hallucinations positioning junction parkinsons fatigue multiple sclerosis positioning motor cortex pfc corresponding electrical field diagrams measured saline filled head included
investigation paper equation fluids equation examined via analysis multi soliton solutions constructed constraint proposed ensure existence solitons equation based constructed solutions propagation interaction including elastic interaction interaction soliton resonance solitons discussed results useful shallow water wave wave elsevier inc rights reserved
high use conventional resources electricity production fact resources diminish every passing day increased studies carried renewable energy sources however use renewable energy sources efficient way possible one topics come fact led technology used illumination systems provides energy saving study electric energy obtained photovoltaic panels accumulated battery groups sensitive illumination intensity motion taken ambient light sensor proposed algorithm controls light level led direct current characters comparison normal led illumination systems energy saving attained
order protect corrosion zinc widely used however hydrogen easily diffuse dislocations steel hydrogen defects inside lattice gaseous form small cracks easily produced due high pressure hydrogen gas research order determine root cause fracture pole resulting hydrogen typical electric motors additional factors accelerate hydrogen fracture selectively applied including small head transition excessive hardness parametric study performed experimentally elsevier ltd rights reserved
shape correspondence fundamental problem computer graphics vision applications various problems including animation texture mapping robotic vision medical imaging many settings shapes allowed undergo non rigid deformations partial views available problem becomes challenging end present non rigid multi part shape matching algorithm assume given reference shape multiple parts undergoing non rigid deformation query parts additionally contaminated overlap parts missing parts redundant ones method simultaneously solves segmentation reference model dense correspondence subsets parts experimental results synthetic real scans demonstrate effectiveness method dealing challenging matching scenario
integrated heat electricity dispatch crucial exploit synergistic benefits integrated energy systems however requires information electricity systems district heating systems managed electricity control center ecc district heating control centers respectively reasons pertaining privacy communication dimension compatibility practical send detailed models ecc therefore new feasible region method proposed formulation new models exploit flexibility consideration building thermal inertia greedy method developed solve new modified feasible region models calculating series linear programming problems efficiently new models sent ecc used central dispatch considering operation constraints integrated heat electricity dispatch modified models similar conventional power plants thus compatible current dispatch programs case studies verify effectiveness method although exists total cost wind energy decreased compared conventional decoupled dispatch elsevier ltd rights reserved
walls subjected plane loading exhibit complex behavior influence several parameters axial load aspect ratio strength materials high rise buildings seismic areas large tensile stresses arise walls vertical horizontal reinforcement often used provide proper resistance increases complexity structural behavior work presents overview experimental behavior unreinforced reinforced walls overview distinct design methods aimed calculating plane lateral resistance proposal new design model reinforced walls subjected plane loading proposed model considers coupling interaction flexural shear mechanisms updates role vertical horizontal reinforcement lateral resistance database composed experimental results plane lateral resistance walls available literature used evaluate performance existing models validate newly proposed model exhibits much better performance doi american society civil engineers
cdna clone oxidase gene isolated non chinese characterized sequence analysis showed high similarity sequence named plant species southern blotting indicated one nuclear gene encoded enzyme non chinese mrna level gene leaves monitored real time pcr different developmental stages different stress conditions results showed expression upregulated light gene responded copper stress inoculation expression leaves increased general peaked post inoculation much higher expression later date cloning gene enable understand function provide useful information resistance breeding program non chinese
remote sensing algorithms often multiple measurements simultaneously retrieve group parameters order create robust retrieval algorithm necessary ensure unique measurements parameters retrieved case inversion multiple solutions sensitive noise letter introduce methodology calculate number possibly fractional degrees information set measurements representing number parameters retrieved robustly set since different measurements mutually independent amount duplicate information calculated using information theoretic concept total correlation generalization mutual information total correlation sensitive full distribution measurement therefore accounts duplicate information even multiple measurements related partially method illustrated using several examples applications variety sensor types discussed
channel morphology step pool represents complex influenced large debris fall aim paper determine impact fall channel morphology step pool general conclusions regarding influence fall channel morphology step pool based results analyses study showed differences river segments without steps pools following steps grain size composition sediment also larger higher retention capacity steps help decrease potential energy water effectively fall preserved step makes resistant extreme water flows result enables development fully functional channel morphology step pool
paper first reviews theory active tendon control decentralized integral force feedback displacement actuator force sensor formal proof formula giving maximum achievable damping provided first time next potential control strategy control suspension bridges active stay cables evaluated numerical model existing several configurations investigated active cables connect deck deck analysis confirms possible provide set targeted modes considerable amount damping reaching finally control strategy demonstrated experimentally laboratory mock equipped four control stay cables equipped piezoelectric actuators experimental results confirm excellent performance robustness control system good agreement predictions
overall objectives research performed materials science engineering project measure improvements student learning outcomes student engagement successful course completion rates possible structure basic materials engineering course transformed primarily practice information communication technology ict enabled inductive teaching learning environment two overarching components project first component required transformation course structure practice inductive practice element supported research results stem education educational theory based cognitive social second component ict support additional research base supports connections ict enhanced collaborative learning distributed cognition enhanced student outcomes propose ict support combined immersion inductive teaching learning environment improve student outcomes either singular component case capabilities touch allowed build applications apps utilize different multi media formats eight different apps built far apps facilitate support daily collaborative learning opportunities target specific student learning objectives known challenging weekly class low help students evaluate building knowledge base three kinds data sets used evaluate research data set one practice data set two inductive practice third data set now collecting similar data set two ict support work progress paper describe project theoretical base apps experiences deployment devices focus group findings national science foundation supporting project
shown second law conservation linear momentum arbitrary types force full formula force used second law effective exerting observable action test element force exerting element massive otherwise immobilized inertial system realistic case finite mass force exerting element free mutual action reaction motion energy observable force action physically effective force exerted test element mass represented product formula force inertial modulation factor omega less equal application elementary result classical shows physics many universally taken since century instance established mathematical theorem closed current loop external straight current carrying test element necessarily exerts zero longitudinal force latter lorentz force law original force law others differing additive exact differential quantity need valid physically reason inertial factor omega overlooked presence extra factor function force differential exact differential nature loop instance external loop physically configured weak link namely section conductor relatively low mass much less high mobility freedom along portion circuit omega approximate whereas circuit anchored laboratory omega approximate hence integral around whole circuit low mass portion circuit much open gap despite presence current easily put observational test using driven tuning bearing straight segments current carrying conductor sensor test element arranged respond longitudinal force confirmed observed alteration resonance response excitation suitably configured weak link external closed electrical circuit indeed cause readily detectable violation closed loop longitudinal force theorem sum exhibited cross talk electromagnetic inertial properties conducting circuits limit applicability many classical concerning closed loops valid special case completely immobilized force exerting circuits circuits parts constrained prescribed states motion free ability classical century made empirical choices among candidate force laws impossible implies now experiments designed allow choices made
mixtures widely used heat transfer fluid research area solar energy applications measured often show large discrepancies due difficulties measurement elevated temperatures especially salt mixtures paper theoretical model presented predicting viscosity binary data viscosity density fraction component salt needed comparisons experimental data show model gives prediction viscosity errors less though part error probably come experiment comparison equation always gives larger errors reaching worst case present work indicates model shows improved ability prediction viscosity salt mixtures elsevier ltd rights reserved
unsteady friction modeling widely studied transient pipe flows influences modification effect pressure waves feature great importance particularly pipe systems extreme pressure values due overlapping pressure waves generated different sections paper investigates relevance unsteady friction term considering different models available literature particular attention focused following two commonly used one dimensional models weighting function based model instantaneous acceleration based model investigation executed using laboratory experiments field tests numerical simulations simple pipeline systems realistic ranges initial conditions geometrical characteristics considered data collected experimental tests first used calibrate unsteady friction models investigation validated models applied identify respective domains applicability limitations differences models data measured using local transient analysis norm integral total energy norm along pipeline reasons discrepancies explored paper practical implications use improvements different unsteady friction models transient pipe flow simulations discussed paper american society civil engineers
study effect urbanization environmental pollution qualitative structural quantitative changes pollen investigated using scanning electron microscopy fourier transform infrared ftir spectroscopy curve fitting analysis profile obtained spectroscopic results show significant variations fraction proteins pollen probably depend various degrees results suggest alterations chemical composition pollen induced urbanization air pollutants potential cause increase incidence allergies people mutations nucleic acids accompanied number molecular changes leading formation proteins seems type habitat pollen grew affects individual differentiation indeed found site exhibiting low pollution pollen contain lower amount proteins ones site high hence ftir spectroscopy curve fitting analysis profile successfully applied tools identifying quantitative qualitative changes proteins pollen anthropogenic factors air pollution urbanization lead changes structure chemical composition pollen fourier transform infrared spectroscopy ftir gaussian analysis showed structural changes pollen collected sites different absorbance values individual chemical functional groups changes secondary structure proteins pollen graphics
testosterone deficiency adult age associated decrease energy muscle mass bone mineral density depression recently testosterone deficiency also associated various components metabolic syndrome turn associated five fold increase risk cardiovascular disease low testosterone levels associated increased insulin resistance increase fat mass low hdl cholesterol higher triglyceride levels hypertension testosterone replacement therapy patients testosterone deficiency type diabetes mellitus metabolic syndrome shown reductions insulin resistance total cholesterol ldl cholesterol triglycerides improvement glycemic control anthropometric parameters elsevier espana slu rights reserved
background alcohol use disorder among prevalent mental disorders worldwide associated diverse range physical psychological comorbidities despite various types treatment many barriers accessing treatment stigma cost accessibility service etc mobile apps potential overcome barriers provide support need objective purpose systematic review assess effectiveness mobile apps reducing alcohol consumption individuals understand psychological outcomes using apps client empowerment self efficacy etc methods search strategy applied health sciences interdisciplinary databases two reviewers independently assess abstracts relevance full texts relevant articles eligibility included article quantitative evaluation clinical outcomes using intervention intervention consumer facing app focused supporting individuals two reviewers independently extract data eligible articles using standardized extraction independently assess study quality meta analysis conducted appropriate depending outcomes reported pooled risk ratios standardized mean differences calculated reported review results search strategy yielded unique citations articles assessed relevant full text review full text reviews currently underway final review projected completed summer conclusions potential mobile apps support individuals reduce alcohol consumption review first assess effectiveness mobile apps client experiences using apps
even rough literature review reveals many alternative ways implementing binary fundamental priority structure one alternatives best practice opinions authors aligned use array course correct answer depends get opinions facts set class written provides variety options used realize large part proposed variants also derived implementations performance work three conclusions drawn difficult achieve space efficiency speed time current number values data structure small positive real size values type space efficiency means space speed means worst case time per push array based solution sufficient original program still day hard beat iii sometimes linked structure programming viable option binary variant need available software library using reading essay save headaches copyright john wiley sons ltd
present study sediment spiked solution explore interaction indigenous bacterial communities sediment results showed sediment rapidly efficiency treatments reached first day respectively quantitative polymerase chain reaction gradient gel electrophoresis analysis indicated affected densities species bacteria significantly response bacterial community favored promoting growth reducing bacteria inhibiting according results sequencing pseudomonas played vital roles degradation presented original bacterial community promoted comparing controls polyphenol oxidase contributed degradation metabolic intermediates respectively paper illustrates rapid induced response indigenous bacterial communities stress improve understandings degradation sediment
objective study pressure variations whole filling phase among different groups patients material methods investigated consecutive patients january june patients recruited within routine practice clinic evaluated urodynamic exam according standards international society ics additional continuous measurement pressure profile done position patients genital grade patients impaired cognitive function neurogenic disorders excluded time investigation excluded urine analysis pressure changes higher considered instability results investigated patients clinically diagnosed oab syndrome stress urinary incontinence mixed oab incontinence prevalence instability defined study mean delta patients oab significantly higher groups pure stress mixed urinary incontinence conclusions etiology instability unknown high prevalence among patients overactive bladder syndrome especially concomitant detrusor activity raise fair question direct diagnostic treatment efforts
paper describes controller design based wind energy generation system using static output feedback technique toolbox features converters controllers discussed lower order nominal representation obtained using numerical differentiation simulink model subsequently used pid controller design obtained results compared existing methods performance enhancement wind energy conversion systems
using ghz like states proposed controlled mutual quantum entity authentication protocol find proposed protocol secure center secret keys shared without detected
blood acid base regulation specialized kidney requires ability sense blood acid base status developed primary cultures ray cells study mechanisms acid base sensing without interference whole animal hormonal regulation ray abundant base cells identified noticeable expression type atpase also express evolutionarily conserved acid base sensor soluble exposure cultured cells extracellular triggered translocation cell membrane similar previous reports live animals experiencing blood translocation dependent blocked specific inhibitor ray base cells also express transmembrane however inhibition prevent dependent translocation activation reduced abundance cell membrane study demonstrates necessary sufficient sensor extracellular ray base cells addition study indicates different sources camp differentially modulate cell biology
future low end embedded systems make increased use heterogeneous utilize systems efficiently methods tools required support extraction implementation parallelism typically found embedded applications ideally large amounts existing legacy code new systems existing parallelization infrastructures however mostly support parallelization according requirements systems resource restricted embedded systems different parallelization strategies necessary achieve additional non functional objectives reduction energy consumption hpc focused parallelization also assumes processor memory communication structures different low end embedded systems therefore wastes optimization opportunities essential improving performance resource constrained embedded systems paper describes new approach infrastructure inspired api support extraction implementation pipeline parallelism commonly found complex embedded applications addition advanced techniques extract parallelism legacy applications requiring minimal code modifications presented resulting combines advanced parallelization mapping communication optimization tools leading efficient approach exploit parallelism typical embedded applications heterogeneous running distributed real time operating systems elsevier inc rights reserved
random numbers highly used applications like computer simulation gambling statistical sampling cryptography high entropy random source produce better quality random data paper work generation high quality random numbers based cellular automata propose three dimensional generate random sequence also propose various enhancements based number generator discuss five variants using two dimensional analyze switching sequence achieve high quality randomness provide architectures rules algorithms proposed variants respect cell structures done software implementation proposed variants tested produced sequences using internationally accepted standard random numbers known analysis results made per recommendations standards similar criteria applied compare methods based results able find best producing high quality random sequence
research behavior change energy use department energy climate change shows better information monthly electricity energy performance encourage people reduce energy usage smart meters emerging technology help people know monthly energy consumption gradually replacing mechanical power meters paper investigate special energy monitoring process named non intrusive load monitoring potentially best method give consumers pertinent information respect power consumption however real time feedback feature low cost system still big challenge technology complication algorithms system chip soc technology solve challenge besides including high speed interconnection multi processors integrating field programmable gate array fpga important evolution provides developers powerful tool develop low cost high performance system therefore paper proposed development real time system based soc fpga acceleration elsevier ltd rights reserved
limited literature data migraine like accompanying features patients cluster headache symptoms frequently reported patients delay diagnosis objectivethe aim present study investigate occurrence migraine like symptoms italian case series patients determine whether features influence clinical phenotype methodsa cross sectional study performed consecutive patients referred headache centre affected cases subsequently reviewed applying beta criteria initial study sample consisted subjects men women identified patients reported least one migraine accompanying symptoms nausea vomiting found patients men initial male sample women initial female sample patients without men initial male sample women initial female sample multiple logistic regression analysis highlighted demographic clinical features significantly characterized patients adjusting confounding frequently female relatively younger age onset expected attacks longer duration accompanied frequent also frequently reported study confirms high proportion patients reported literature presence seems relate peculiar demographic clinical characteristics whether features influence response therapy remains determined
reactive oxygen species generated product metabolism play central role development obesity obesity related metabolic complications objective current study explore possibility block obesity improve metabolic homeostasis via natural antioxidant product apple tree leaves preventive therapeutic activities assessed using high fat diet induced obesity mouse model injected twice weekly regular obese mice fed high fat diet effects treatment body weight composition fat content liver glucose lipid metabolism insulin resistance monitored compared control animals treatment significantly blocks high fat diet induced weight gain induce weight loss obese animals improved glucose homeostasis insulin sensitivity alleviated hepatic lipid accumulation pcr analysis showed treatment suppresses expression macrophage markers pro inflammatory genes mcp enhances adiponectin gene expression white adipose tissue addition treatment elevated expression fatty acid oxidation genes reduced expression monocyte protein mcp novo transcriptional factor activated receptor gamma ppar gamma target genes results provide direct evidence support possible use mitigation obesity maintenance metabolic homeostasis
article reflects way path creation theorem influenced intervention designed overcome intractable challenge community university partnership province south africa intractable challenge related legacy abc campaign mounted early reduce global impact hiv aids despite context hiv aids epidemic shifted significantly since abc community partner focus hiv aids related work reported abc legacy continued source frustration work order begin process overcoming challenge partnership decided beyond conventional boundaries community based hiv aids discourses develop intervention influenced complexity guiding heuristic design path creation theorem placing special emphasis initial conditions contingency self reinforcing mechanisms lock findings reflection indicate concepts associated path creation added value design particularly perspective incorporating processes emergence contingent events article concludes suggesting path creation theorem flexible heuristic application opened opportunities explore managing complex systems conventional forms managing community based interventions relating hiv aids
child apparently desire cause harm partner childs parent standard explanations fail provide adequate solution call problem problem killer comes take former partner child child point although victim acknowledged occur occurs understood offer hypothesis killer fails represent child moral subject mind due deficit capacity person perception hypothesis pathological killer experiences child object rather person significant emotional value parent specificity disorder explains partner targeted explains killer able understand killing child harm parent elsevier ltd rights reserved
electrical generator certain device power source servo system electrical systems traditional detection methods electrical generator usually need manufacture great deal special device items fact difficult carry operation processes complicated low degree article hardware software design projects based virtual instrument technology detection system deeply researched based labview electrical parameter detection technology serial port communication technology hardware system electric quantity detection modules used isolation adjustment units making cost low security high serial port transport used data communication general computers software system lab view used developing platform data acquisition detection designed based general serial port driver program labview system signals saved data log files labview detection process data monitored time detection data reported files technology detection system greatly develop detection efficiency electrical generator device also reduce developing cost detection system
introduction recent development focused new administration methods formulations combination therapies treatment related novel serotonin receptor subtype agonists areas covered clinical research related migraine reviewed analyzing embase pubmed data bases focus clinical trials class level evidence advances drug combination therapies administration devices aid ease use increase efficacy decrease adverse reactions new agents devices similar less efficacy compared previous generic formulations new agents action receptor subtype avoid vascular side effects classic agonists however adverse reactions limit clinic use long half life appear good benefit related migraine expert opinion recent advances development offer advantages migraine therapy patient preferences much higher cost compared individual generic agents coming years advances high efficacy limiting cost regard already established
view large number machining parameters influence system dynamics experimental study performed using associations deep hole drilling process varying cutting parameters rotational frequency drilling feed rate tool usage considered input process specimens tested considered output process study first order fuzzy models designed using cutting parameters input data output data relation input output created find influence input parameters output surface quality terms error hence best cutting condition deep hole drilling designated improve output scheme recommended precisely create relationship different cutting parameters using clustering procedure based first order fuzzy model minimum error model lesser numbers rules error established exploration clustering parameters resulted model best clustering factors using adaptive neuro fuzzy inference system
background mental form mental training used physicians nurses improve performance clinical skills vital component stress management training help novice nurses deal often stressful clinical events require processing information essential patient management mental strategy developed implemented year nursing simulation program inherent mental imagery facilitates cognitive affective modification reduction cognitive load expected mental strategy improve students performance reduce stress managing patients methods study used mixed methods design eighteen year nursing students participated pre post design study consisted development implementation mental strategy patient situations tool used assess performance heart rates systolic blood pressures used measure stress state trait anxiety inventory used psychological measure stress anxiety five participants involved focus group discussion evaluated usefulness mental strategy results significant improvement performance however post test heart rate systolic blood pressure significantly different pre test measures comparison results show significant differences pre post test state anxiety pre post test trait anxiety three themes emerged focus group interview managing stress using mental framework integrating realistic simulations mental strategy conclusion mental strategy patient management valuable based findings performance based participants feedback role reducing stress however needs evaluation elsevier ltd rights reserved
previous studies performed magnet systems brought important information detection consequences function initial conditions deposited energy heated length even temperature margin correction coils high behavior also studied since likely triggered potential anomalies joints ground fault instrumentation wires etc model developed code side correction coil four cooled parallel represented module proper cable conductor characteristics coils cooling loop connected parallel top bottom correction coils six field coils modeled flower modules equivalent hydraulics properties model analysis results presented five initiation cases without fast discharge two initiated heat input turn one case case two initiated turns four case case case initiated middle turn one impact cooling circuit opening pressure relief valves detailed case discharge magnet particular attention also paid possible secondary detection system based measured signals pressure temperature mass flow rate maximum cable temperature achieved case fast current discharge primary detection voltage compared design hot spot criterion includes contribution elsevier ltd rights reserved
performance two critical metrics embedded systems real time requirements owing complexity current embedded systems along increased application demands real time operating systems become solution providing specific services system tasks however extra layer abstracts hardware software makes system achieve good performance ease impact system run time services hardware layer paper presents hybrid implementation several critical services software hardware improving system latency special focus given handling subsystem developed hardware field programmable gate array fpga exploiting point point fast simplex link bus soft core processor approach shows hybrid better performance compared software version
objective present research examine association lifetime cannabis use disorder current suicidal ideation lifetime history suicide attempts large diverse sample era veterans using battery validated instruments expected associated current suicidal ideation lifetime suicide attempts even accounting effects sex posttraumatic stress disorder depression alcohol use disorder non cannabis drug use disorder history childhood sexual abuse combat exposure thus findings present study suggest unique predictor suicide attempts among era veterans however significant limitation present study cross sectional design prospective research aimed understanding complex relationship mental health problems suicidal behavior among veterans clearly needed present time published elsevier ltd
study presents animal mobility system equipped positioning running wheel way quantify efficacy exercise activity reducing severity effects stroke rats system provides effective animal exercise training commercially available systems running wheels contrast achieve speeds min rats permitted run stable speed min high density rubber running track supported wide wheel diameter work using predefined adaptive acceleration curve system reduces operator error also trains rats run specified intensity reached way evaluate exercise effectiveness real time position rat detected four pairs infrared sensors deployed running wheel adaptive acceleration curve initiated using microcontroller data obtained infrared sensors automatically recorded analyzed computer comparison purposes week training conducted rats using surgically inducing middle cerebral artery occlusion modified neurological severity scores inclined plane test conducted assess neurological damages rats experimentally validated effective among animal mobility systems furthermore exercise effectiveness measure based rat position analysis showed high negative correlation effective exercise volume employed quantify rat training type brain damage reduction experiments
species intracellular pathogens infect animals natural hosts transmission humans commonly caused direct contact infected animals ingestion contaminated food lead severe chronic infections professional non professional cells within endoplasmic reticulum derived host factors required entry host cells avoidance lysosomal degradation replication like compartment remain largely unknown describe two assays identify host factors involved entry replication hela cells protocols describe use rna interference alternative screening methods applied assays based detection labeled bacteria labeled host cells using automated wide field microscopy fluorescent images analyzed using standardized image analysis pipeline allows single cell based infection scoring endpoint assay intracellular replication measured two days infection allows bacteria traffic niche proliferation initiated around bacterial entry successfully established intracellular niche thus strongly inside host cells since intracellular bacteria greatly individual extracellular intracellular non bacteria strain constitutively expressing gfp used strong gfp signal used identify infected cells contrast entry assay essential differentiate intracellular extracellular bacteria strain encoding inducible gfp used induction gfp simultaneous inactivation extracellular bacteria enables differentiation intracellular extracellular bacteria based gfp signal intracellular bacteria able express gfp allows robust detection single intracellular bacteria intracellular proliferation initiated
uptake regulator iron dependent transcriptional regulator regulates genes related iron acquisition oxidative stress response various functions transcription typically self regulating sensitive iron oxidative stress following identification gene genome bovine pathogen attempt made characterize transcriptional control northern blotting pcr primer extension done determine transcribed using three distinct promoters two located within upstream gene third promoter located upstream conserved hypothetical protein drives transcription message quantitative real time pcr experiments indicated unlike current models regulation transcription unchanged iron depletion phase iron depletion stationary phase elsevier rights reserved
rna binding proteins implicated cancer development integrated bioinformatics analysis various datasets revealed several genetic altered events among identified mutated differentially regulated samples mutations predicted poor prognosis copy number variation dna methylation mirna targeting contributed differential regulation two sets differentially regulated implicated initial transformation glioma progression identified also identified four signature unique expression pattern glioma stem like cells independent poor prognostic indicator risk score derived signature also stratified low risk high risk groups significant survival difference silencing inhibited maintenance gene set enrichment analysis differentially regulated genes high risk low risk importance inflammation emt hypoxia high risk thus provide comprehensive overview genetic epigenetic regulation glioma development progression
objectives study evaluates whether certain patient parental characteristics associated referral versus primary pediatrics care pediatric irritable bowel syndrome ibs methods retrospective clinical trial sample patients meeting pediatric rome iii ibs criteria assembled single metropolitan health care system baseline socioeconomic status ses clinical symptom measures gathered various instruments measured participant parental psychosocial traits study outcomes stratified referral versus primary pediatrics care two separate analyses ses measures clinical symptoms psychosocial measures identified key factors univariate multiple logistic regression analyses analysis identified factors placed unadjusted adjusted multivariate logistic regression models assess impact predicting participants referred pediatric managed primary pediatrics care ses clinical symptom factors child self assessment abdominal pain duration lower percentage people living poverty strongest predictors referral among psychosocial measures parental assessment childs functional disability sole predictor referral multivariate logistic regression models selected factors continued predict referral socioeconomic environment clinical symptoms functional disability associated referral future interventions designed ameliorate effect identified factors reduce unnecessary specialty consultations health care ibs
introducing time flight image sensors actual engineering applications pattern recognition constrained limited depth lateral resolution also similar precision depth measurement throughout whole pixel matrix real operating environment observed scene hardly exhibits homogeneous reflectance factor moreover light beam laser source presents optical power distribution space thus amount incident light sensor surface varies drastically one pixel another signal noise ratio address problem paper investigates impact scene light source non ideal characteristics sensor performance adaptive pixel analog signal processing technique also presented applied design complementary metal oxide semiconductor cmos range camera featuring interesting cost efficient solution
advances nano electronics manufacturing technology rapid size logic circuits made prone errors led need fast circuit reliability evaluation large logic circuits paper new method reliability analysis logic circuits based modified form rule proposed utilizing matrix sparsity significantly increases speed reduces required memory proposed approach addition approach introduced mitigate effect paths simulation results indicate proposed method scalable runs faster previously proposed schemes published elsevier ltd
terms theories techniques network security packet capture protocol analysis branch network security protocols depend widely used insecure protocols present day paper mainly discusses capture analysis network packets subsequently designs capture program network packets meanwhile working principle internal structure function libraries captured based packets namely analyzed carefully detailed analysis elementary implement principles methods approaches current capture analysis system network packets describing capture analysis system network packets specific design implement methods packet capturing analyzing system end paper states predicts directions implement methods network data monitoring analyzing
real time information vital enhance dynamic control management via information sharing analysis order reduce construction conflicts project delays however construction project management programs ineffective project prompt responses especially respect change management work presents novel construction project management system called web project based change management system system responds changes information efficiently order facilitate change management among project participants general contractor construction project environment capable increasing information sharing construction change management web based technology also provide cost savings via internet case study involving commercial building project taiwan demonstrates effectiveness proposed system information sharing change control construction phase addition increasing efficiency change control management general contractor dynamic project tracking management proposed system enables access manage change information timely future work implement system functions comprehensively apply system additional projects strictly verification reliability
inferring properties interaction matrix characterizes nodes networked system directly interact known network reconstruction problem despite decade extensive studies network reconstruction remains outstanding challenge fundamental limitations governing properties interaction matrix pattern sign pattern degree sequence inferred given temporal data individual nodes remain unknown rigorously derive necessary conditions reconstruct property interaction matrix find property interaction matrix difficult interaction matrix requiring equally informative temporal data revealing fundamental limitations sheds light design better network reconstruction algorithms offer practical improvements existing methods
peptide produce complex metabolites using template mechanism catalysis study demonstrate loading reductase domain performs two consecutive reductions release bound corresponding using mechanism catalysis first crystal structure domain mycobacterium tuberculosis provides strong support mechanistic model suggests displacement intermediate required cofactor recycling show produce committed intermediate reduction intermediate least times efficient substrate structural biochemical studies also provide evidence conformational changes associated cycle show large substrate binding pocket hydrophobic platform accounts remarkable substrate domains studies present example recruitment canonical short chain dehydrogenase reductase family member loading domain context assembly line enzymology
objective increased risk self harm suicide compared general population risk suicide release prison three times greater still however surprisingly little known incidence self harm following release prison aimed determine incidence identify risk factors characterise emergency department presentations resulting self harm adults release prison method cohort study adults interviewed prior release prison linked prospectively state emergency department records data emergency department presentations resulting self harm coded characterise presentations used negative binomial regression identify independent predictors presentations results person years follow median per participant emergency department presentations participants presented due self harm accounting presentations crude incidence rates self harm males females confidence interval confidence interval per person years respectively presenting due self harm associated indigenous incidence rate ratio confidence interval lifetime history mental disorder incidence rate ratio confidence interval previously psychiatric treatment incidence rate ratio confidence interval previously presented due self harm incidence rate ratio confidence interval conclusion following release prison one presented emergency department due self harm within average release demographic mental health variables help identify risk groups presentations provide opportunities suicide prevention population transition prison community challenging particularly history mental disorder mental health support release reduce risk adverse outcomes including self harm
many colleges universities adopting cloud computing defined distributed computing system provides access virtual resources including computer hardware networks software development platforms memory site location accessed locally thus far development driven primarily hope administrative benefits cloud also presents excellent opportunities chemical educators moving cloud allow every student class access resources necessary class simply accepting join site encourages collaboration development new educational models
work report structural mechanical magnetic properties mechanically formation grain size lattice parameter internal strain investigated using ray diffraction xrd measurements morphological aspect nanostructured analysed means scanning electron microscopy sem circular shape test micro hardness magnetic measurements loops discussed results according milling time show milling grain refinement internal strain around micro hardness increases decrease grain size loop milling enhanced term decreased
paper describes variable output voltage multi phase switched capacitor step converter digital voltage regulation scheme implemented cmos technology number conversion ratios generated using capacitors order scheme selection switch presented expressions equivalent series resistance conduction switching power loss efficiency obtained compared cadence simulation results step open loop converter circuit one gain described analysed varying switching frequency open loop converter efficiency achieved bottom plate parasitic capacitance load current input voltage mhz switching frequency gain voltage regulation scheme desired output voltage designed digital control circuit using inherent capacitive dac various gain configuration capacitor simulated cadence analog mixed signal flow using cmos technology layout design using cap done back annotation results presented
background although plant reported almost years ago mechanism action still understood recombinant peptide derived one isoforms presents biotechnological interest since toxic insects different orders previous studies group using disease vector model insect showed treatment led aggregation among effects work employed cell biology biochemical approaches investigate whether induce cellular also humoral immune responses species results findings indicated doses triggered cation dependent vitro aggregation fifth adults use specific synthesis inhibitors revealed cellular immune response required cyclooxygenase products since prevented dependent aggregation whereas inhibitors pathway cultured incubated showed cytoskeleton chromatin condensation positive activated caspase apoptosis marker although activity remained unchanged finally vivo treatments injection induced cellular response observed aggregation humoral response seen increase spontaneous activity key enzyme involved defense hand humoral response elicited injections lead increment antibacterial activities injections also impaired clearance pathogenic bacteria staphylococcus aureus leading increased mortality indicating possible immunosuppression induced treatment peptide conclusions experimental conditions part toxic action activates responses immune system vivo vitro although induction protect insects posterior bacterial infections taken together findings contribute general knowledge insect immunity light mechanism action
paper address effect thickness core structure electrochemical cell measurements properties zno core objective elucidate mechanisms responsible extended zno core solar radiation aligned zno core fabricated tin oxide substrates using grown zno cores samples structure characterized ray diffraction revealing mixed structures zno cores improvement structure increases thickness optical properties studied optical absorbance measurements showing optical properties featured type heterogeneous nanostructures constructed zno electrochemical impedance spectroscopy eis employed equivalent circuit model designed suggesting cell performances affected increasing deposition times plots several parameters flat band potential free carrier concentration determined next measurements highest density produced electrode prepared deposition time min reached applied potential value times much measured zno one provided highest value solar hydrogen energy efficiency eta results encouraging suggest covered zno nanostructures valuable photo order build cheap devices solar energy hydrogen generation devices hydrogen energy publications llc published elsevier ltd rights reserved
insect cytochrome play important role leading resistance insect populations pest developed resistance wide range present study novel gene cloned function assessed using rna interference rnai monitoring resistance levels three commonly used including beta full length complementary dna sequence long open reading frame encoding amino acid residues quantitative reverse transcriptase polymerase chain reaction analyses larval development indicated expression highest fifth larvae followed fat body expression regulated beta lethal concentration respectively dosages respectively addition significantly increased toxicity beta suggesting marked three mediated detoxification rnai mediated silencing increased mortality fifth larvae exposed beta respectively dose levels results demonstrate play important role beta detoxification
thermal imaging become readily usable tool crop agricultural water management since allows quick determination canopy surface temperature linked give idea crop water status last years resolution thermal imaging systems increased weight decreased fostering implementation unmanned aerial vehicles uav civil agricultural engineering purposes approach overcome limitations site thermal imaging allowing mapping plant water status either field farm scale taking thus account naturally existing artificially induced variability scales aim work evaluate extent high resolution thermal imaging allows evaluating instantaneous seasonal variability water status within novelty significance approach specifically designed build unmanned aerial vehicle uav provided high resolution imaging pixel used commercially relevant set used obtain crop water stress index thermal images clear day values compared stem water potential psi conductance measured sampling sites across moment images acquired order evaluate potential acquired single day estimate within patterns variation water status spatial modeling approach used correlated moment image acquisition showing great potential monitor instantaneous variations water status within information provided thermal images proved relevant seasonal scale although match seasonal trends water status physiological processes occurring therefore picture variations water status required necessary acquire thermal images several dates along summer elsevier rights reserved
brain damage ischemia cytokine interleukin beta rapidly upregulated due activation studied whether interleukin beta influences cortical spreading depolarization whether lipopolysaccharide often used microglial stimulation influences cortical spreading rats cortical spreading elicited interleukin beta receptor antagonist gaba receptor blocker lipopolysaccharide administered either alone combined interleukin beta receptor antagonist interleukin beta lipopolysaccharide receptor antagonist local cortical treatment area using cortical spreading recorded non treatment treatment area plasma cortical grey matter assessed blue local application interleukin beta reduced cortical spreading depolarization amplitudes treatment area high dose reduction prevented receptor antagonist however interleukin beta induced pronounced plasma independently cortical spreading application lipopolysaccharide reduced cortical spreading depolarization amplitudes prolonged duration eeg activity still present effects also blocked receptor antagonist interleukin beta changes neuronal activity vascular functions thus although reduction cortical spreading depolarization amplitudes lower doses interleukin beta reduce deleterious effects cortical spreading sum interleukin beta effects excitability vasculature rather promote brain damaging mechanisms
paper presents smart way control shape wing open loop architecture actuation system uses smart material actuators shape memory alloys two parallel actuation lines control performed type fuzzy logic proportional derivative controller wing project description actuation system structure control design validation highlighted paper results obtained numerical simulation experimental validation bench tests wind tunnel tests presented part control design validation analysis wind flow characteristics based information provided pressure sensors mounted flexible skin wing wind tunnel tests included supplementary validation transition laminar turbulent flows real time visualized aerodynamic efficiency controlled wing evaluated american society civil engineers
calcium dependent enzymes catalyze formation epsilon gamma lysine bonds specific lysine residues isoforms present brain thought participate protein aggregation characteristic neurological diseases alzheimers parkinsons disease developed functional proteomics strategy amine donor amine acceptor probes used identify substrates present brain bioinformatics analyses revealed brain substrates identified interacted amyloid precursor protein alpha synuclein neurological disease significant canonical pathway associated substrates physiological relevance substrates identified mass spectrometry confirmed fact three actin beta subunit neuronal cells cytosolic calcium concentration raised also showed situ substrates part protein aggregates found neurological diseases results strongly support idea activity brain participates formation protein aggregates found diseases central nervous system elsevier inc rights reserved
rome iii criteria classify patients constipation two main groups patients functional constipation patients constipation predominant irritable bowel syndrome ibs purpose study identify differences intensity symptoms total colonic transit time two types patients performed prospective evaluation outpatients consecutively referred chronic constipation classified according rome iii criteria ibs asked report symptom intensity point likert scale diarrhea constipation abdominal pain stool form reported using scale colonic transit time measured using multiple ingestion single marker single film technique statistical analysis completed discriminant analysis female gender frequent ibs patients patients ibs patients reported greater symptom intensity patients stool form total colonic transit time different two groups multivariate logistic regression showed two parameters abdominal pain related ibs phenotype discriminant analysis showed two parameters sufficient give correct classification patients study suggests self evaluation abdominal pain helpful colonic transit time classifying patient
objective trait meta mood scale item self assessment questionnaire developed measure perceived emotional intelligence level dimensions attention clarity repair study aimed explore psychometric properties french version instrument method instrument factor structure internal consistency stability concurrent validity assessed sample young adults female besides participants completed self assessment questionnaires shortened beck depression inventory state trait anxiety inventory positive negative emotion scale questionnaire interpersonal functioning empathy quotient discriminant validity tested female patients anorexia nervosa identified literature difficulties expression emotional regulation results confirmatory factor analysis results replicate factor structure internal consistency reliability indices adequate direction degree correlation coefficients dimensions questionnaires support instrument concurrent validity allows highlight differences perceived levels men women attention clarity patients anorexia nervosa control subjects dimensions conclusion first validation study shows satisfying psychometric properties french version trait meta mood scale est auto questionnaire items dimensions les version structure plus les participants complete des auto questionnaires shortened beck depression inventory trait anxiety inventory positives questionnaire empathy quotient des regulation les structure les indices des coefficients correlation les dimensions les questionnaires evidence des differences die les les attention des des les dimensions conclusion validation des version
data models knowledge models often use engineering difference technical field short presentation knowledge models offers pre defined solutions delivering knowledge process interested data models put accepted format piece reality purpose paper underline difference two notions notion knowledge components explicit implicit knowledge approach consists review science literature also presented notion surface knowledge examples work placed context manufacturing engineering technology field
integrating next generation sequencing ngs bioinformatics electron microscopy conventional molecular biology tools new virus infecting identified characterized associated double membrane bound bodies infected tissues genome composed rna segments one containing single open reading frame negative polarity virus shows typical features members genus five genomic rna segments identified additional molecular signatures viral rnas proteins encode together data phylogenetic analyses support proposal creating new species genus classify novel virus named associated virus showed mechanically plants turn develop spots field surveys disclosed presence four different species five different provinces central western china support association novel virus symptoms leaf data molecular features small rnas nucleotides derived rnas targeted host rna silencing mechanisms also reported possible molecular pathways involved biogenesis discussed
background evidence shows negative impact irritable bowel syndrome quality life patients suffer condition compared general population objective objective study determine health related quality life adults irritable bowel syndrome receiving treatment specialist hospital material methods study cross sectional prospective design study included consecutive patients diagnosed irritable bowel syndrome rome iii criteria attending outpatient questionnaire applied standard spanish version results compared population reference scores mexico statistical analysis performed students test analysis variance chi squared test considering significance results one hundred fifty four patients included study women men average age constipation diarrhea mixed subtypes comprised patients respectively quality life patients irritable bowel syndrome population reference scores mexico physical health sub scale mental health sub scale respectively significant difference found quality life among irritable bowel syndrome subtypes conclusions health related quality life lower patients irritable bowel syndrome population north east mexico compared data taken population reference study undertaken country enabling inference female population one results found small male sample studied significant difference found quality life according clinical subtype irritable bowel syndrome
measurement system developed using micro distance imaging technology measure droplet sizes field droplet images acquired single lens reflex camera micro distance lens illumination source proper parameters droplets extracted effectively based background region growing repair shape factor screening points matching methods droplet including area diameter volume calculated using matlab image processing technology system displayed droplet sizes distribution regulation graphs convenient obtaining experimental regulation indoor comparison experiments developed system oil disk method conducted average relative errors respectively field comparison experiments revealed relative error developed system oil disk method developed system laser instrument method application experiments field conducted result revealed fine droplets better penetration coarse droplets tree canopy system simple structure lower cost compared instruments reduced experimental time compared image processing methods use oil good prospect use elsevier ltd rights reserved
reduced ascorbic acid converted oxidized state oxidase present study gene regulated rna interference tomato via agrobacterium mediated transformation existence rna interference dna transformed plants confirmed polymerase chain reaction amplification southern blotting expression levels transgenic lines monitored semi quantitative reverse transcriptase polymerase chain reaction decreased enzyme activity significantly improved content tomato fruit observed correlated gene suppression transgenic plants suppression improvement exhibited higher photosynthesis capacity control drought stress report demonstrates oxidation pathway rna interference provides feasible approach improve content plants regulating genes related metabolism
time delays dead time found many processes industrial practice time delays mainly caused time required transport mass energy information many cases time delay caused effect produced accumulation large number low order systems one possibilities control processes approximation lower order model time delay contribution focused design algorithm digital control high order process approximated second order model time delay controller algorithms use digital modification linear quadratic predictor criterion combined pole assignment principle algorithms applied control set equal liquid cylinder atmospheric tanks
comparison sets genome intervals genes repeats chip seq peaks essential genome research especially modern sequencing technologies enable ever larger complex experiments relationships genomic features commonly identified intersection feature sets contain overlapping intervals inferred share common biological function origin using technique researchers identify genomic regions common among multiple unique individuals data sets recent advances algorithms pairwise two sets genomic intervals advances made intersection many sets genomic intervals identifying among many interval sets particularly important attempting biological insights massive multidimensional data sets common modern genome research analyses speed efficiency crucial given size number data sets involved solve problem present novel slice algorithm given interval sets efficiently reveals subset intervals common sets demonstrate algorithm efficient sequential case higher capacity parallelization speedup existing algorithm
nations fight fat reduced obesity effects mental health researchers raised possibility intense pressures lose weight heightened risks developing eating disorders especially among young medical help connect dots war fat disordered eating identifying specific mechanisms pathways contextual forces lie beyond scope biomedical psychiatric research article develops approach focuses necessity thin fit body belonging category work pervasive fat talk defining belong ethnographic narratives california illuminate dynamics individual lives powerful support idea fat worsening disordered eating eating disorders among vulnerable young people
paper presents experience community based initiatives water demand management project five year project terms community based initiatives water management project designed build capacity local community based organizations raise awareness level around water demand management engage community members water management measures showed local solutions decrease reliance public water systems ultimately help facing water shortage national level paper also showed site rainwater harvesting funded project able harvest annually paper found rainwater harvesting household level able save average potable water per year elsevier rights reserved
patients polycythemia vera experience shortened survival increased risk thromboembolic hemorrhagic events symptoms patients treatment aspirin control recommended addition patients high risk status poor control benefit therapy hydroxyurea although approximately patients develops resistance intolerance patients resistant hydroxyurea studies shown ruxolitinib janus kinase inhibitor provides control reduces spleen size blood counts improves related symptoms many patients managed community health setting important community familiar contemporary management improve patient outcomes including management patients present unique health care needs review provides overview current treatment options patients discusses challenging circumstances encountered community providers management including symptom assessment identification hydroxyurea resistance intolerance pregnancy elective surgeries concomitant managing patients areas limited access specialized hematologic care author published karger basel
background work related stress highly prevalent educational sector aim current study evaluate effectiveness organizational level participatory intervention need recovery vitality educational workers hypothesized intervention decrease need recovery increase vitality methods quasi experiment conducted two secondary vocational education training schools months follow measurements intervention consisted needs assessment phase wherein staff teachers developed actions happy healthy working supervision implementation phase wherein actions implemented management teams mixed model analysis applied order assess differences intervention control group average time analyses corrected baseline values several covariates results effects intervention found need recovery vitality secondary outcomes two small statistically significant effects unfavorable direction intervention group scored average time significantly lower absorption subscale work engagement organizational efficacy control group conclusions since beneficial effects intervention found primary secondary outcomes implementation intervention current form eligible recommend future organizational level interventions occupational health incorporate elaborate implementation strategy specific relating actions stressors context integrated secondary preventive individual focused stress management interventions
coronary heart disease leading cause premature death men epidemiological studies shown high prevalence low serum testosterone levels men cardiovascular disease cvd furthermore low testosterone level associated observational studies increase cardiovascular events mortality testosterone beneficial effects several cardiovascular risk factors include cholesterol endothelial dysfunction inflammation key mediators atherosclerosis bidirectional relationship low endogenous testosterone levels concurrent illness attempts validate causality association potential mechanistic actions complex testosterone hormone predominantly actions several vascular beds although studies reported conflicting effects clinical studies acute chronic testosterone administration increases coronary artery diameter flow improves cardiac symptoms men chronic stable reduces peripheral vascular resistance chronic heart failure although mechanism action testosterone vascular tone vivo understood laboratory research found testosterone calcium channel blocker induces potassium channel activation vascular smooth muscle cells animal studies consistently demonstrated testosterone whereas testosterone deficiency promotes early stages translational effects testosterone vitro animal human studies conflicting effects discussed review review evidence role testosterone vascular health therapeutic potential safety men cvd possible underlying mechanisms
sparse representation based classifier kernel sparse representation based classifier founded combining pattern recognition compressive sensing methods provide acceptable results many machine learning problems nevertheless classifiers suffer shortcomings instance accuracy drops samples directional classes output declines data normally distributed kernel space paper introduces nonparametric kernel sparse representation based classifier generalized framework first applies kernel samples overcome data employs nonparametric discriminant analysis reduce data dimensionality kernel space alleviating concern data distribution type experimental results demonstrate superiority equal superior performance respect pca synthetic four known face recognition several datasets published elsevier
misinformation effect defined impairment memory past events due exposure misleading information people susceptible misinformation effect others also depend response event purpose current study investigate several key factors contribute misinformation susceptibility events namely posttraumatic stress disorder symptoms avoidance dissociation participants watched either neutral trauma film rated level distress completed measures trait state dissociation participants returned week later misinformation introduced via statement free recall assessed findings indicated dissociation related higher distress ratings following film related acceptance misinformation however avoidance scores related increased recall misinformation items reported experiences related greater accuracy results discussed light paradoxical negative emotion hypothesis
background health service providers restrict access contraceptives imposed biases method appropriateness study provider biases toward contraceptive service provision among urban providers assessed methods health providers working health facilities pharmacists patent medical city surveyed concerning self reported biases service provision based age parity marital status results minimum age bias common bias minimum parity least common bias reported providers condoms consistently provided least amount bias followed provision emergency contraception pills experience service training health facility providers associated decreased prevalence marital status bias pill iud however training experience opposite effect pharmacists operators reports service provision bias conclusions provider imposed eligibility barriers urban study sites nigeria pervasive prevalent restriction across method provider type minimum age given large growing adolescent population interventions aimed increasing supportive provision contraceptives youth context urgently needed results show effect service training provider biases limited future efforts address provider biases contraceptive service provision among provider types find creative ways address critical barrier increased contraceptive use
people use impressions evaluative targets self esteem infer socially desirable traits people still use self esteem proxy trait relevant diagnostic information available test possibility two experiments participants learn target person low high self esteem receive diagnostic information targets academic success failure positive negative study video targets behavior study experiments participants impressions targets traits accurately tracked diagnostic information impressions also revealed independent self esteem proxy effect self esteem proxy robust influences person perception even presence information
financial incentives used increasingly encourage wide array health behaviors established efficacy however little known translate incentive based strategies public health practice toward improving population level health dearth research exists individuals respond incentives public health communication strategies direct study reports results population based randomized controlled trial testing direct incentive based intervention promoting uptake study population composed random sample women enrolled medicare fee service breast cancer screening participants randomized three groups direct direct plus incentive control direct groups received two message importance however plus incentive also offered incentive getting logistic regression analyses measured intervention effects results showed odds receiving significantly higher direct plus incentive group compared direct control groups use incentives also proved cost effective additionally direct group likely receive control group findings offer experimental evidence population based strategy direct coupled financial incentive encourage healthy behavior incentive based programs translated health promotion practice aimed achieving population level impact
paper presents development implementation evaluation online tool personalized mobile learning engineering graphics online tool designed support widespread mobile operating systems android ios windows mobile interactive enable learning framework developed tool includes file storage application interactive cad application various tools drawing study conducted sample undergraduate students students divided experimental group using developed online tool personalized mobile learning control group using traditional learning tools statistical analysis samples carried order study effectiveness online tool learning process results final test showed students experimental group successful students control group therefore use developed online tool personalized mobile learning engineering graphics considered improvement teaching engineering graphics
japanese guideline diagnosis treatment allergic diseases includes minor revision japanese pediatric guideline treatment management asthma japanese society pediatric allergy clinical immunology section child asthma provides information diagnose asthma infancy adolescence years age makes recommendations best practices management childhood asthma including management acute exacerbations non pharmacological pharmacological management guideline interest non specialist physicians involved care children asthma differs global initiative asthma guideline emphasizes diagnosis early intervention children asthma years years age first choice treatment depends severity frequency symptoms pharmacological management including step step drugs used long term management based status asthma control levels easy understand thus guideline suitable routine medical care children asthma also recommends using control test children physician aims complete control avoiding factors appropriately using anti inflammatory drugs example inhaled corticosteroids receptor antagonists copyright japanese society production hosting elsevier
staphylococcus aureus important food borne opportunistic pathogen frequently causes severe blood tissue infections even fatal illnesses although aureus extensively studied livestock poultry foods china limited information reported aquatic products accordingly study aimed characterize aureus aquatic products retail markets china total aquatic food samples collected china results showed samples positive aureus qualitative quantitative analyses contamination levels samples ranged mpn six samples exceeded mpn total aureus isolates positive samples selected evaluate virulence factors antibiotic resistance molecular characteristics aureus isolates evaluated presence virulence genes multiplex polymerase chain reaction binding protein aureus see identified major genes genes formed different profiles major profile identified antimicrobial susceptibility isolates analyzed disk diffusion method results showed high resistance susceptibility addition sequence types obtained via sequence typing including seven novel among common isolates negative nine isolates carrying evaluated cassette chromosome typing types isolates showed high prevalence multidrug resistant results showed aquatic products vehicle transmission virulence genes multidrug resistant aureus representing potential public health risk identified study indicated genetic diversity aureus thereby providing important basic data dissemination aureus aquatic products
objective parents children autism spectrum disorders asd often focus concerns discussions health care providers however studying child strengths positive parental attributions emerging area focus often highlighted many studies children asd objective study identify parent reported strengths sample children qualitative study parent report strengths clinical notes children ages presenting team diagnostic evaluation meeting diagnostic statistical manual mental disorders dsm text revision dsm diagnostic criteria asd reported childs strengths qualitatively analyzed coded clustered ninety eight charts reviewed five meta themes strengths identified personality characteristics social personality cognitive functioning behavioral characteristics coping mechanisms skills average parents reported strengths cognitive functioning personality characteristics meta pediatricians unique opportunity discuss parental positive perceptions children asd learn strengths
background internal hip moment major indicator hip loading new hip concept designed area hip osteoarthritis via external rotation force intended alter weight bearing area reduce compression joint objective assess effect novel hip rotation transverse planes hip moment study design repeated measures methods gait analysis performed subjects unilateral symptomatic hip osteoarthritis pain joint motion moments vertical ground reaction force compared control randomly assigned conditions results nine participants felt immediate reduction pain walking hip peak hip moment significantly decreased osteoarthritis side peak hip internal rotation angles significantly decreased stance conclusion wearing appear reduce compressive joint reaction force interface indicated reduction internal hip moment along immediate pain reduction nine participants long term studies warranted
examined whether tumor necrosis factor alpha tnf alpha promotes inflammation myocardial injury via activation nuclear factor kappa kappa vivo canine model dogs underwent closed chest occlusion anterior coronary artery minutes followed hours dogs randomly received soluble tnf inhibitor etanercept saline occlusion blood flow risk region size risk measured radioactive size measured chloride staining inflammation measured tissue activity intercellular adhesion molecular messenger acid mrna measured northern blotting protein expression measured western blotting kappa activation measured nuclear extracts mobility shift assays risk significantly smaller etanercept group saline control group adjusting flow analysis covariance mean reduction risk versus activity mrna protein expression kappa binding activity significantly reduced etanercept group administration soluble tnf inhibitor reduced kappa activation upregulation myocardial injury following ischemia tnf appears play significant role vivo genesis inflammation
find general way choose suitable samples training classifier even limited prior information active learning regarded iterative optimization procedure plays key role construct refined training set improve classification performance variety applications text analysis image recognition social network modeling etc although combining samples proven promising active sampling state art methods perform certain data structures find way two active sampling criteria without assumption data paper proposes general active learning framework effectively two criteria inspired two sample discrepancy problem triple measures designed guarantee query samples possess data also reveal diversity labeled data appropriate similarity measure employed construct triple measures meanwhile uncertain measure generate criterion carried different ways rooted framework practical active learning algorithm proposed exploits radial basis function together estimated probabilities construct triple measures modified best versus strategy construct uncertain measure respectively experimental results benchmark datasets demonstrate algorithm consistently achieves superior performance state art active learning algorithms
symptomatic chronic disease affects patients infected lack reliable early markers cure therapy hinders disease management clinical trials new drugs performed study months follow compare changes immune parameters specific immune responses surrogate markers response therapy patients treated untreated patients pilot open label randomised clinical trial treatment versus treatment patients chronic infection groups investigated changes cell activation cell subpopulations regulatory cell counts levels specific immune responses responses fourteen patients included study seven group median age years female administered day days three patients discontinued owing adverse reactions evaluated end follow period treated patients showed significantly less immune activation lower regulatory cell counts increased response randomised pilot clinical trial administering patients chronic disease brings changes adaptive immunity leading general decrease inflammatory status apparently beneficial response act basis monitoring new drugs elsevier rights reserved
objectives assess veterans spinal cord injury sci limb following patient demographics medical factors cultural psychosocial characteristic race quality race independent associations patient race factors quality design cross sectional cohort study setting three department veterans medical centers affiliated academic medical centers participants eligible participants veterans sci als completed interview analyses restricted white african american participants variation quality among patients excluded descriptive analyses leading final sample size interventions applicable main outcome measure quality defined medicare healthcare common procedure coding system results found race differences many variables quality manual odds ratio confidence interval power several factors including age income associated quality significant associations cultural psychosocial factors quality conclusions although racial differences quality found significant association older age lower income poorer quality among veterans efforts needed raise awareness disparities among providers take steps eliminate disparities prescription practice across sites published elsevier inc behalf american congress rehabilitation medicine
aim study develop korean version stigma scale chronic illness items assess reliability construct validity among patients neurological conditions patients diagnosed stroke parkinsons disease epilepsy multiple sclerosis amyotrophic lateral sclerosis recruited reliability assessed internal consistency cronbachs alpha coefficient exploratory factor analysis used extract potential factors korean convergent validity assessed correlating scores korean scores depression using beck depression inventory anxiety using state trait anxiety inventory functional ability using korean modified index respectively total patients enrolled study recruited stroke parkinsons disease epilepsy korean high internal consistency cronbachs alpha korean retrieved one factor eight items factor loading scores korean correlated positively depression anxiety negatively study shows korean model even though includes items internalized stigma reliable valid assessing stigma among korean patients neurological disease
many clinical molecular features fragile syndrome common form intellectual disability autism modeled deletion protein mice previous studies showed decreased expression several components system knockout mice used mouse model investigate functional consequences deletion hippocampal inhibition region hippocampus whole cell patch clamp recordings demonstrated significantly reduced amplitude evoked inhibitory currents decrease amplitude frequency spontaneous addition reduced amplitude frequency significantly slower controls quantitative real time pcr revealed significantly lower expression alpha beta delta gaba receptor subunits hippocampus juvenile mice compared wild type correspondingly found also protein level reduced amounts alpha beta delta subunits knockout mice overall results demonstrate reduction several components system already present young age reduction results measurable abnormalities receptor mediated inhibition abnormalities contribute behavioral cognitive deficits fragile mouse model elsevier ltd rights reserved
paper focused performance optimization applications based non relational databases firstly explained differences relational non relational databases also compared types non relational databases advantages disadvantages sql database systems described compared database systems implemented web server speed compared order determine system better use different conditions tasks
active stealth important developing direction modern stealth technology field based scattering properties characteristics linear frequency modulated signal matched filter cancellation signal designed stealth achieved interference cancellation cancellation signal radar echo signal simulation results show complete stealth achieved echo signal scattering field reduced almost even cancellation error proposed method provide important reference active stealth project realization
background aims association health anxiety maladaptive internet use established finding studies performed examine possible effect abnormal illness behavior maladaptive manner experiencing evaluating acting response health illness disproportionate evident pathology aim study investigate association internet addiction severity sample italian university students possible effect anxiety depression also taken account methods participants men women mean age years measured via illness behavior questionnaire severity internet addiction test results powerful factor predicting severity scores disease irritability emotional factor associated severity nevertheless disease remained significant predictors scores hierarchical regression analysis executed discussion conclusions results support previous findings showing characterized health anxiety prone excessive maladaptive use internet moreover study showed irritability emotional aspect predicting severity finding consistent cognitive model states cognitive factors dysfunctional beliefs assumptions play major role explanation psychopathological condition
extensive research field building modelling adaptive increasingly predictive control inclusion predictive control building energy management control systems shifts calculation optimum control strategies future allows prompt evaluation various control scenarios energy saving potential based demand controlled ventilation established although several studies investigated potential incorporating building energy indoor air quality management cases applications reactive rather predictive incorporating concentration factor predictive models optimisation opportunities controller applications especially buildings highly varied occupancy institutional buildings objective study investigate potential creating predictive models tailored specific spaces order estimate future concentrations purpose measured simulated data combined simulated data provided detailed building model final identified model concentration state space representation derived prediction error method results suggest indeed potential least short term prediction using simple identification procedure elsevier rights reserved
actuation systems lower limbs extensively investigated presently great effort aimed reducing weight improving efficiency thus increasing operating range battery operated devices work innovative efficient actuation system power knee joint proposed key elements alternative design micro variable transmission particular powertrain configuration permits exploit efficiently dynamics human locomotion offers possibility recover energy means simulations level ground walking running demonstrated storing energy permits reduce energy consumption electric motor
objectives conventional material decomposition techniques dual energy computed tomography assume mass volume conservation number voxel fully assigned predefined materials present image domain contrast material extraction process method preferentially extracts contrast producing materials leaving remaining image intact materials methods image processing used perform consecutive arithmetic operations dual energy ratio map generate applied original images generate material specific images first low energy image divided high energy image generate ratio map ratio map split material specific ratio intervals known correspond particular materials iodine calcium assigned multiplier whereas ratio values intervals assigned linear gradients original image produce material specific images method tested quantitatively dual source rapid switching using pure mixed formulations calcium iodine errors evaluated comparing known material concentrations derived material specific images qualitative evaluation performed vivo rabbit model using identical parameters phantom orally administered administered iodine skeletal calcium used contrast materials results material combinations iodine calcium mixtures calcium iodine calcium showed distinct dual energy ratios largely independent material concentration dual source successful vivo pure contrast materials phantom maximum error known derived material concentrations iodine calcium respectively mixtures iodine calcium showed highest discrepancies reflected sensitivity iodine image type chosen extraction final material specific image rabbit model able clearly show extracted material phases vascular iodine oral skeletal calcium skeletal calcium extracted iodine image however impede vasculature conclusions straightforward image domain approach extract material signal dual energy particular value separation experimental high contrast elements conventional iodine contrast calcium even exact attenuation coefficient profiles desired contrast materials unknown readily implemented image domain within adapted use images multiple
multiple sclerosis chronic degenerative condition heterogeneous symptoms unpredictable prognosis previous literature suggests patients experiences healthcare unsatisfactory primary care play key role management people however provision services received little focus primary care literature study aimed explore perspectives experiences healthcare professionals healthcare services semi structured interviews conducted practice nurses general practitioners specialist nurses northern england october april participants selected data analysed thematically using constant comparative analysis theoretical framework used data themes mapping onto national institute health care excellence guideline interpreted symptoms leading care help seeking required additional support identifying symptoms due participants reported poor experiences care including poor access services poor continuity care poor interpersonal interactions perceptions limited person professionals identified related disability progression symptoms required responsive care relational continuity enabled feel understood professionals symptoms progression conclusion continuity patient care central positive healthcare experiences professionals services need accessible ensure responsive effective management study provides unique findings role primary care relationship findings guideline recommendations implications service delivery community
china characterized low fertility intention strong preference sons stringent birth control policy study used data fertility intention behavior survey questionnaires conducted province china event history analysis methods examine effect fertility intention preference sons probability second child results validate correlation fertility intention second child empirically even low fertility intention stringent birth control context china also show women preference sons less likely second child women son preference turn sex selective abortion ensure first child son thus reducing likelihood second child decreasing fertility rate findings also light chinas potential fertility policy adjustment
article revisit problem supporting two dimensional range queries present data structure words space query time improves work factor query time factor element space cost arbitrary positive constant data structure matches state art two dimensional range queries achieves optimal query time structure applications computational geometry text indexing elsevier rights reserved
world experts different disciplines molecular biology recognize value ecosystems ideal ecological evolutionary laboratories among taxa stand intriguing model organisms ecological role top unique adaptations medium sensitivity anthropogenic disturbance description first array papers biology ecology evolution published comprehensive review topics still lacking provide general overview families recorded habitats worldwide review different adaptations life summarize information gathered far origin population structure ecology conservation status finally point limits knowledge currently regarding aiming stimulate future research
background hypoxia causes secondary headaches high altitude headache headache due acute mountain secondary headaches mimic primary headaches migraine suggests common link review discuss possible role hypoxia migraine cluster headache methods narrative review investigates current level knowledge relation hypoxia migraine cluster headache based epidemiological experimental studies findings epidemiological studies suggest living high altitude areas increases risk migraine especially migraine aura human models show hypoxia migraine without aura whereas cluster headache reliably induced hypoxia possible pathophysiological mechanisms include hypoxia induced release nitric oxide gene related peptide cortical spreading depression leakage blood brain barrier conclusion possible link hypoxia migraine cluster headache exact mechanism currently unknown models hypoxia yielded interesting results suggesting novel approach study depth mechanism underlying hypoxia primary headaches
paper possibilities analog signal processing afford towards lower power consumption low latency solutions emerging antenna array wireless systems discussed shown analog processor construct used propagation difficult enhanced trust systems approach permits operation real time analog processing power consumption data throughput limits associated current digital signal processing hardware
result assignment federal investigation behavioral science unit author consulted knowledge cases discussed book came believe middle ground victims true accurate distorted symbolic contaminated false problem challenge however determine basically much sets forth seeds truth many concerns inconsistent definitions referred many refers book narrative many professionals including possibly seem fully aware wide diversity ways children sexually author delayed reporting minimization recent cases involving inaccurate stereotypes child abuse narrative law enforcement perspective benefit come extensive research focused documenting became inaccurate less far ranging harm caused narrative authors opinion process narrative caused long term damage discussed
background oxidative stress induce cell injury vascular endothelial cells initial event development atherosclerosis although quantitative real time polymerase chain reaction qrt pcr widely used gene expression studies oxidative stress injuries using carefully validated reference genes received sufficient attention related studies objective study therefore select set stably expressed reference genes use qrt pcr normalization oxidative stress injuries human umbilical vein endothelial cells induced hydrogen peroxide results using analysis found five stably expressed reference genes sufficient normalization qrt pcr analysis treated genes stable expression according according conclusion taken together study demonstrated expression stability reference genes differ according statistical program used optimal set reference genes studies gene expression performed qrt pcr assays oxidative stress study
purpose study explored turkish university students views women related roles sexuality violence women method cross sectional study conducted females university turkey survey exploring students views female sexuality violence used comparisons responses made among groups based sex year study university field study university results three relevant findings found male students traditional approaches toward womens issues female students educational levels fields study significantly influence students views women small percentage students violence women discussion results show values turkish society influence formation students opinions university education alone affect views gender roles womens sexuality violence women
systemic investigation energy metabolism frame brain theory supply chains describe transport chain beginning energy exploration remote environment energy consumed neurons brain modeling main difficulty consists selection significant core models among enormous member known substances regulatory mechanisms considerable uncertainties general supplement standard bottom modeling certain mechanisms approach therefore investigate general supply chains indispensable elements regulatory mechanisms available observations critical selection system properties underlying mechanisms enables simulate observations explained classical theory observations nearly constant energy level brain different responses periphery brain periods finally development diabetes
articular bone erosion rheumatoid arthritis mediated interaction inflammation pathways regulating bone metabolism inflammation promotes also inhibits osteoblast function contributing persistence micrornas mirnas important regulators skeletal remodeling play role pathogenesis therefore determined expression mirnas inflamed synovial tissue role play pathways regulating osteoblast osteoclast function using serum transfer mouse model mice performed high throughput qpcr based screening mirnas mice global gene expression profiling also performed microarrays synovial samples mirna mrna expression profiles subjected comparative bioinformatics total upregulated genes downregulated genes identified predicted targets mirnas reciprocal expression changes gene ontology analysis genes revealed significant enrichment skeletal pathways mirnas whose expression significantly changed mice identified targets inhibit promote bone formation mirnas predicted target wnt signaling pathway components validated mirna array findings demonstrated secretion mir upregulated synovial fibroblasts treated proinflammatory cytokine tnf overexpression mir suppressed osteoblast differentiation mineralization vitro results suggest mirnas derived inflamed synovial tissues regulate signaling pathways erosion sites affect bone loss potentially also compensatory bone formation american society bone mineral research
introduction hypothyroidism silent epidemic times india prevalence hypothyroidism effect hypothyroidism respiratory system studies suggesting obstructive restrictive disease patterns symptoms range mild life threatening respiratory failure study emphasizes effect hypothyroidism dynamic respiratory functions aim find changes dynamic respiratory functions fvc male female hypothyroid patients within age group years materials methods cross sectional study conducted mission medical college india total number newly detected cases sexes years age group attending outpatient department enrolled patients previous respiratory diseases history smoking excluded filled followed clinical examination performed using data analysed paired test analysis variance anova test results mean observed values dynamic pulmonary parameters showed highly significant difference predicted mean parameters also decreased considerably age gender bmi statistically significant conclusion findings suggest respiratory abnormality newly detected cases hypothyroidism shows mixed pattern highlights investigating patient respiratory disorder thyroid status always effects hypothyroidism reversed proper treatment
quality caregiver child relationship key children assumptions based research western countries benefits different types substitute care applied elsewhere study assessed quality caregiver child relationships association child abuse foster residential care nigeria findings relevant european north american countries looked care england african heritage easy draw wrong conclusions care received countries study children aged years foster residential care settings assessed caregiver child relationship using positive relationship scale child abuse measure covered physical sexual emotional components aggregated single score subsequent analysis explored differences child abuse foster residential care significance factors influencing levels child abuse found children residential care positive relationships caregivers foster care even though abuse occurred settings gender differences experiences child abuse either setting children age significantly likely abused care age children residential care age significant factor associated abuse findings provide perspective children substitute care west african city useful social workers elsewhere responsible children african heritage suggest abuse often occurs foster homes child relationships residential good
known high frequency excitation modify behavior systems respect slow motions goal study consideration effects rather general case analytical systems modulated sinusoidal excitation method direct separation motions proposed applied modified form explicit introduction small parameter equations slow motions obtained analysis depend structure original equations performed five basic effects corresponding different possible dependencies modulation amplitude position velocity slow time selected first time effects offer possibility designing high frequency control slow motions specified properties example high frequency excitation system nonlinear friction essentially increase effective damping results also significance system identification diagnostics analysis hydraulic valve given example application elsevier ltd rights reserved
new intelligent hybrid structure used online tuning pid controller proposed paper structure based two adaptive neural networks built orthogonal polynomials first network regular orthogonal neural network implemented artificial endocrine factor form environmental stimuli weights used approximation control signals processing system deviation disturbance signals introduced form environmental stimuli output values used calculate artificial environmental stimuli aes represent required adaptation measure second network orthogonal endocrine adaptive neuro fuzzy inference system used process control output error signals system generate adjustable values proportional derivative integral parameters used online tuning pid controller developed structure experimentally tested laboratory model system terms analysing tracking performances deviation signals error signals payload performances compared traditional pid intelligent pid type controllers tracking performance comparisons transient steady state period showed proposed adaptive controller possesses performances within range tested controllers main contribution structure significant minimization deviation signals compared controllers recommended exploit dealing highly nonlinear system operates presence undesirable disturbances elsevier ltd rights reserved
objective review compare epidemiology treatment mandibular fractures subgroups pediatric population methods conducted retrospective review pediatric patients age years mandibular fractures treated institution january november results identified patients male mandibular fractures prevalent mechanisms injury motor vehicle accidents sports injuries assault common fracture sites angle body two patients treated observation underwent fixation alone underwent fixation plate fixation underwent plate fixation average duration fixation days range days complications occurred patients mean follow days range days fifty patients comorbid conditions history mental illness time injury including attention deficit hyperactivity disorder mental disorders attention deficit hyperactivity disorder asthma twenty six patients history substance use common tobacco alcohol conclusions treatment approach outcomes affected age fracture characteristics addition marked proportion cohort preexisting mental disorders history substance use implications treatment approach elsevier ireland ltd rights reserved
introduction one quarter human immunodeficiency virus hiv infected persons also found hepatitis virus hcv infected general population hcv genotype shown prevalent one present first study distribution hcv genotypes among hiv hcv infected patients relation epidemiological clinical features material methods study included hiv hcv infected group hcv mono infected patients period collection epidemiological clinical behavioral data using standardized questionnaire hcv genotyping level pure genotype performed reverse hybridization results intravenous drug use found significantly prevalent among infected patients hcv genotype detected patients mono infection compared patients infection genotypes significantly common among infected patients respectively multivariate logistic regression confirmed infection non hcv genotype hcv viral load log predictors hiv infection conclusions hcv genotypes found significantly prevalent among hiv hcv infected patients compared hcv mono infected patients also prevalent compared european hiv hcv infected cohort history represents independent predictor hcv genotypes infection important implications treatment
background face mild generally recommended care occasionally general public exacerbated furthermore concerns inducing skin irritation intensive washing recently developed new based sodium without penetrating stratum methodswe designed controlled clinical trial conducted adult japanese males moderate less twenty subjects faces base twice day assessment efficacy conducted prior start study end weeks improvement observed within lesions detectable subjects week secretion levels skin significantly increased significantly decreased correlated improvement complaints irritation occurred study face twice day facial based effective care moderate less grade facial
background cognitive differences including deficits self awareness common high functioning individuals autism spectrum disorder asd represent target intervention current project presents preliminary research undertaken development metacognitive training intervention designed increase knowledge personal strengths challenges adolescents two groups adolescents asd completed measures assess satisfaction adverse effects visual inspection thematic analysis used interpret overall participants parents rated youth interactive activities whereas parents appreciated opportunity systematic changes quantitative measures adverse effects self esteem depression conclusion although results suggest investigation warranted certain modifications protocol research methodology needed
background studies pathophysiology comorbidities associated frontal limited objective purpose study determine prevalence androgen excess postmenopausal population relation demographics comorbidities methods retrospective data analysis patients seen department dermatology clinic foundation conducted cohort patients met inclusion criteria results androgen excess identified patients subtypes androgen deficiency identified patients androgen excess group significantly likely present dermatitis ovary syndrome ovarian combination limitations study limited retrospective conclusion study demonstrated associated androgen excess associated androgen deficiency
order meet development advanced manufacturing technology based requirement engineering training colleges new period advanced manufacturing engineering training platform established paper authors introduce details framework function analyze run platform sum application numerical control manufacturing practice
background need challenge messages reinforce harmful negative discourses around sexual risk responsibility priority improving sexual health mass media important source information regularly updating influencing public opinions way sexual health issues framed play crucial role shaping expectations responsible sexual health risks healthy sexual practices methods conducted depth qualitative analysis negatively articles reporting sexual health topics examine risk responsibility framed within relation gender articles published seven three national included latent content analysis approach taken focusing interpreting underlying meaning text results key theme articles men framed risk womens sexual health whilst part womens role resist mens advances discourses tended power imbalance sexual relationships women men number articles argued women needed take responsibility sexual health articles repeatedly suggested women girls particular lacked skills confidence negotiate safer sex sex education programmes often presented failed men frequently engaging risky sexual health behaviours women yet just one article attention lack focus male responsibility sexual health gay men used bench mark rates measured framed risk risk conclusions framing men risk women whilst women presented time responsible sexual encounters contraception preventing sexual health gender stereotypes efforts promote collective responsibility sexual health implications sexual health prevention continue reinforce negative culture around sex relationships sexual health
study intended define implement activities ensure acquisition generic skills evaluate acquisition students perspective latter teacher research focuses official studies develop field advanced manufacturing engineering open teaching obtain data combined analysis teachers internal vision student surveys external view results insight give idea activities designed although focused knowledge abilities technology skills combining methodology implicitly generic skills moreover external view corroborate especially considering student profile specialty studied also detect aspect improving
evaluate parents feedback regarding experience accessing funding national disability insurance scheme communicating national disability insurance agency children less age assessed child development unit womens childrens health network july june referred invited complete study questionnaire regarding experience questionnaire initially parents response returned families complete questionnaire phone sent another copy questionnaire complete children eligible study parents completed questionnaire thirty six parents reported difficulty registration process six parents difficulty regards accessing funding reported difficulty stated difficult parents twenty six parents reported easy communicate found difficult overall parents satisfied neutral conclusionthe majority parents satisfied processes required register access funding early intervention services children developmental disabilities ability communicate
episodic events happened happen persons past past events important aspects mental life affecting emotions decisions behaviors however studies examining phenomenological characteristics content introduced new method systematically compare self generated episodic self generated episodic memories future projections regard phenomenological characteristics imagery emotional valence content reference cultural life affected temporal distance month year years findings showed three types events differed first episodic memories remembered easily sensory details field perspective compared future projections episodic second episodic future projections positive central life story identity episodic memories episodic third episodic differed episodic memories future projections neither positivity bias future events enhanced sensory details past events across three event types sensory details decreased whereas importance reference cultural life centrality increased increasing temporal distance findings show events different memories experienced events consistent reality monitoring theory future events different actual past events consistent theories motivation
aggressive behavior genetic environmental components many association studies performed identify genetic factors underlying aggressive behaviors humans review summarize previous work performed field considering candidate gene genome wide association studies gwas excluding performed samples primary diagnosis psychiatric neurological disorder aggression related phenotype subsequently studied enrichment pathways functions gwas data results searches show identified associations genes involved dopaminergic serotonergic neurotransmission hormone regulation hand gwas yet identified genome wide significant associations top nominal findings related several signaling pathways guidance estrogen receptor signaling also neurodevelopmental processes synaptic plasticity future studies use larger samples homogeneous phenotypes standardized measurements identify genes underlie aggressive behaviors humans wiley periodicals inc
solar battery storage technologies known provide savings customers form reduced electricity charges currently savings determined volume component kwh demand component interest grows commercial solar battery storage need predict demand charge reductions great aim research determine accuracy reliability ability solar battery storage technologies reducing demand charges results shown simulated commercial scale electricity consumption profile solar able reduce maximum demand across five electricity networks australia coupled kwh battery storage additional reduction experienced battery utilisation strategy shown critical yielding greater demand reduction battery storage notably shown energy electricity network battery storage able supply demand lower cost network able results detail first instance demand reduction evaluation solar coupled battery storage focusing physical financial outcomes australian context elsevier ltd rights reserved
mutually coupling lines transmission signal crosstalk coupling lines shows complex propagation characteristics caused reciprocal reflections usually differential equation integral equation applied analyze solutions transmission lines paper propose different analytical method propagation characteristics signal crosstalk noise setting crosstalk coupling line divided digital transmission network using signal flow graph difference equation propagation characteristics frequency domain space domain time domain mutually coupling lines obtained verify validity method analyze complex propagation problems first study crosstalk characteristics pair cable via third circuit unidirectional coupling subsequently analyze coupling theory bidirectional coupling lines
paradoxical tensions become salient organizations time paradox studies thus far primarily focused tensions inside organizations managed rendered salient actors using longitudinal embedded case study four strategic business units within media organization role top management team leaders practices enabling tensions become salient respective lower level managers initial differences tensions interpreted across levels findings extend dynamic equilibrium model organizing adding context enabling condition shapes emergence salience provision cues guide informed practice based perspective paradox also contribute conceptual model leadership practice outline implications studies
purpose review review discuss basic fundamentals perform molecular imaging better understand contributing cardiovascular disease report findings molecular imaging combines molecular biology vivo imaging molecular probes used target discrete biological processes cell death inflammation angiogenesis probes signals detected traditional imaging systems disease processes manifest individuals different ways molecular imaging emerge important strategy delivering precision medicine summary molecular imaging powerful tool help physicians provide personalized care near future
florida red responsible detrimental effects human environmental health production thought synthesized synthase complex gene cluster yet identified eight transcripts identified high throughput cdna library screening full length sequences obtained race demonstrated presence identical specific leader sequence end transcripts six transcripts encoded individual domains one one transcript encoded acyl carrier protein domains transcript lengths ranged nucleotides based sequence analysis confirmed northern blotting phylogenetic analysis domains placed within type thus although similar type modular presence individual catalytic domains separate transcripts suggests protein structure similar type catalytic domain individual protein results identify unprecedented structure toxic published elsevier gmbh
objective evaluate horizontal migration human mental birth methods fixed fetuses weeks gestation radiographs children aged years investigated distances mental mental distances posterior border mandibular mental determined according development periods results results confirm mental moves posterior direction development mandible conclusion horizontal location pre postnatal mental changes posterior direction development progresses however prenatal mental features irregular behavior postnatal mental gradually regular pattern elsevier ireland ltd rights reserved
purpose receptor signaling molecule important role regulation lymphocyte activity correlation gene polymorphisms immune related diseases reported current study aimed investigate association polymorphisms positions emerged haplotypes susceptibility thyroid carcinoma methods one hundred five patients confirmed thyroid cancer healthy individuals control group enrolled genotypes identified using pcr rflp nested pcr rflp methods results analyzed spss software packages results analysis revealed significant increase frequency mutant allele heterozygous genotype patients thyroid cancer comparison controls genotype position observed significantly higher among controls patients significant differences frequencies genotypes alleles locus patients control group despite haplotype emerged positions also observed significant increased frequency patients controls conclusion first study investigate two mentioned polymorphisms thyroid cancer current study confirmed association polymorphism haplotype resulted loci susceptibility thyroid cancer
activity hypothalamus pituitary thyroid axis coordinated thyrotropin releasing hormone neurons present nucleus hypothalamus neurons act energy sensors controls synthesis release thyrotropin activates synthesis secretion thyroid hormones target tissues transporters control local availability thyroid hormones regulate many functions including energy homeostasis review discusses recent evidence covers several aspects role axis regulation knowledge mechanisms signaling steadily increased new transcription factors engaged gene expression identified advances made interact signaling pathways define dynamics neurons response acute long term influences albeit yet incomplete relationship neurons activity positive energy balance emerged importance central relay feedback control axis responses alterations energy balance stimuli reinforced finally studies started light interference prenatal postnatal stress nutrition confirmed axis susceptibility early
background review focuses treatment emergent mania tem associated repetitive transcranial magnetic stimulation methods english language studies involving possible induced mania published retrieved medline search using search terms mania mixed affective state treatment emergent repetitive transcranial magnetic stimulation fifteen case series controlled studies describing tem associated treatment published involving individuals diagnosed either bipolar disorder major depressive disorder results shown possibly induce manic episodes patients depression sometimes also taking antidepressants high frequency low frequency different stimulus parameters associated tem males females conclusions given findings highly recommended patients bipolar disorder experiencing depressive episode prescribed mood patients diagnosed major depressive disorder consider possibility bipolar disorder treatment initiated tem occurs discontinuation considered continuing mood stabilizing medications research needed concerning underlying neurobiological mechanisms epidemiologic characteristics tem associated
purpose purpose article investigate possible differences effect three types acute treatment cluster headache patients methods fifty seven patients according criteria participated single blinded placebo controlled crossover inpatient study attacks treated oxygen delivered demand valve oxygen simple mask min placebo delivered minutes primary endpoint two point decrease pain five point rating scale within minutes results patients multiple attacks reached point placebo significant differences primary endpoints minutes two point decrease using compared placebo minutes pain free pain relief using placebo preferred compared simple mask first attack significantly better achieving pain relief minutes treatment reduced need rescue medication compared simple mask respectively treatment related adverse events observed conclusion primary endpoint pain relief minutes non significant however post hoc analysis first attack significantly favored therapy resulted decreased need rescue medication recommend patients offered oxygen therapy
paper addresses problem developing user interfaces ubiquitous computing ambient intelligence ami systems kind systems expected provide natural user experience considering interaction modalities adapted user abilities preferences using interaction devices present environment interaction devices necessarily known design time task quite complicated due variety devices technologies diversity scenarios usually burdens developer need create many different order consider user environment combinations propose abstraction framework ami systems effectively improves portability systems different environments different users allows developers design implement single capable deployed different devices modalities regardless physical location
introduction recently novel calr mutations discovered janus kinase non mutated myelofibrosis pmf essential thrombocythemia cases frequency examined clinical correlations calr mutation frequency myeloproliferative neoplasms mpn cases introduce effective test method use clinical practice methods examined samples previously investigated mutation differential diagnosis mpn calr mutations analyzed using melting curve analysis electrophoresis respectively next constructed test simultaneous screening calr mutations utilizing high resolution melting results among mpn cases possessed mutation alone mpn cases without mutation positive calr mutation using novel screening test calr mutations concordance rate conventional analysis mutation calr mutation conclusion novel simultaneous screening test calr gene mutations useful diagnosis mpn authors published elsevier
relative historic documents received little attention researchers source data now many historic placed online traditionally resource potential yield new information sites especially heavily developed urban areas sites article methodology proposed searched data sites case study using county principal city demonstrates utility methodology producing evidence many previously sites
background longitudinal patient centered care represents challenge general practitioners gps context systems offer targeted support study aimed identify details contents care addressed mode display electronic health record visual appearance personnel responsibilities editing applying use patient recall methods mixed methods study comprised cross sectional survey among practices german university network structured observations utilization six practices based clinical describing senior care needs descriptive statistics performed survey data practice observations analyzed different types results seventy three practices completed survey reported using frequent care contents addressed allergies adverse drug events preventive measures participation disease management programs chronic diseases upcoming practice observations showed variety mainly self configured patients information displayed compiled separate field scattered throughout window visual appearance electronic varied colored fields short text entries codes pre defined colors within treatment documentation symbols within treatment documentation symbols linked free text fields traffic light schemes five practices self designed needed one practice applied embedded pre defined system practices used mean aspects care detailed clinical range standard deviation practices needed min mean retrieve information requested conclusions practices use self designed visual aspects care yet data based sophisticated solutions needed improve longitudinal care
improve service delivery also generate across boundaries examine nature size water pollution rivers flow across panel data water pollution brazilian rivers coupled county change locations allow identify spatial patterns pollution rivers approach cross controlling fixed effects trends specific location theory predicts pollution increase increasing rate river approaches downstream exit border structural break slope pollution function border larger number managing exacerbate pollution find support four predictions data satellite data growth night time along rivers show local authorities allow develop close rivers downstream portions counties likely underlying mechanism border effects pollution pronounced cost inter coordination lower
software defined networking recently emerged become one promising solutions future internet logical controllers global network overview brings chance strengthen network security however also brings dangerous increase potential threats paper apply deep learning approach flow based anomaly detection environment build deep neural network model intrusion detection system train model dataset work just use six basic features easily obtained environment taken features dataset experiments confirm deep learning approach shows strong potential used flow based anomaly detection environments
although introduction commercial rgb sensors enabled significant progress visual navigation methods mobile robots structured light based sensors like microsoft pro live important limitations respect range field view depth measurements accuracy recent introduction second generation based time flight measurement principle brought robotics computer vision researchers sensor overcomes limitations however new just like older one intended computer games human motion capture rather navigation unclear much navigation methods visual benefit improved parameters many publicly available rgb data sets provide ground truth information necessary evaluating navigation methods best knowledge none contains sequences registered new version therefore paper describes new rgb data set first attempt systematically evaluate indoor navigation algorithms data two different sensors environment along trajectories data set contains synchronized rgb frames sensors appropriate ground truth external motion capture system based distributed cameras describe details data registration procedure evaluate rgb visual algorithm obtained sequences investigating specific properties limitations sensors influence performance navigation method
teaching algorithms programming concepts students first years computer science course major challenge students often difficulty understanding subject leading high dropout rate institution dropout rate first year computer science course led think pedagogical strategies reduce number use learning objects gained ground higher education experiments developed help teach programming concepts students early years experiments applied use teaching programming concepts however one difficulties encountered previous experiences identify ideal moment introduce students therefore conducted new experiment two groups students using teach sorting concepts first group introduced started teaching theoretical concepts second group initially taught theoretical concepts later introduced study aims present methodology used carry experiment results achieved
climate change late period temperate tropical zones major driver shaping species distributions understanding various effects climate change population dynamics marine species temperate zones california growing however studies demographic history rare description regional climate change affected high trophic level marine species investigated whether demographic history reflects population change consistent past changes climate california also explored whether past changes affected demographic history marine organisms similar way found test hypotheses sequenced fragment mitochondrial dna cytochrome gene base pairs performed tests investigate whether demographic change occurred within results approaches used consistent historical demographic expansion analyses test test mismatch distribution analysis mda associated demographic parameters bayesian plots consistent model population expansion mda estimated expansion event similar present confidence interval whereas showed population growth began similar lasted similar discuss possible associations demographic expansion species large scale ecological shifts demographic expansions marine species
paper presents innovative approach based hardware software develop seismic monitoring data acquisition embedded system hardware designed using basic electronic components integrated circuits consists two parts signal processing microcontroller circuits signal processing circuit combination low pass filter gain control high pass filter offset circuits proposed data acquisition system able record data sampling rate bit resolution three modes real time monitoring continuous recording seismic detected seismic signals filtered using analog filters low pass khz high pass universal serial bus utilized communicate hardware personal computer graphical user interface based windows operating system developed using microsoft net framework transferring processing analyzing data system tested experimental results showing performance proposed system presented earth scientists use system educational seismic experiments easily modified used engineering applications
child protection continues pressing social problem robust relevant research essential order ensure scale nature child maltreatment understood preventative protective measures effective paper reports selected results mapping review research conducted published january december purpose review twofold develop typology child protection research use typology describe features patterns empirical research undertaken recently order inform future research agenda paper reports maltreatment types topics research designs used within empirical research published academic journals identifies number challenges field including need conceptual clarity regarding types abuse greater methodological diversity shift focus response prevention child maltreatment importance national strategic agenda also copyright john wiley sons ltd
accuracy reliability anomaly based network intrusion detection system dependent quality data used build normal behavior profile however obtaining datasets trivial due privacy suitability issues paper presents approach traffic trace based identification anomalous patterns three dimensional entropy space flow traffic data captured campus network anomaly free datasets generated filtering attacks traffic pieces modify typical position entropy space analyses performed real life traffic traces show datasets homogeneity consistency terms cluster probability distributions pca transformed entropy space
prior reviews behavioral treatments individuals comorbid alcohol drug use disorders substance use disorder sud posttraumatic stress disorder ptsd systematically considered whether comparison conditions matched target treatments time attention systematic literature search using pubmed mesh terms alcohol substance use disorders ptsd treatment identified relevant behavioral randomized clinical trials rcts evaluated ptsd oriented exposure based treatments addiction focused treatments coping based treatments involve exposure trauma memories information pertaining within subject changes time subject differences quality control condition recruitment efficiency assessment treatment retention synthesized alcohol drug outcomes described separately possible twenty four behavioral rcts identified exposure based addiction focused coping based seven studies included sud intervention comparison conditions matched target intervention time attention studies found participants experimental control conditions improved significantly time sud ptsd outcomes study found significant group differences sud ptsd outcomes favoring experimental treatment despite greater treatment dropout greater improvement ptsd outcomes exposure based interventions control conditions including control conditions matched time attention addiction focused coping based interventions generally show advantage robust controls although coping based interventions yielded better drug use outcomes control conditions available interventions integrate exposure based ptsd treatment behavioral sud treatment recommended associated better ptsd outcomes sud care matched time attention however results critical review also suggest people sud ptsd benefit variety treatment options including standard sud care
paper presents three phase power supply ups sinusoidal pulse width modulation based division summation sigma digital control ups controls power flow link utility grid tracks reference voltage proposed control law derived sigma digital approach takes account effects link voltage fluctuation grid voltage distortion inductance variation due different current levels thus distortion input current filter inductor core size reduced significantly however circulating current flow common ground input power factor pfc output three phase four wire inverter derived control law based suppress circulating current regulate output voltages tightly experimental results measured three phase ups confirmed analysis discussion proposed control approach
present study defined aggressive behavior males antisocial personality disorder aspd measured following acute intranasal oxytocin dosing international units placebo using validated laboratory task human aggression point aggression paradigm provides participants concurrently available monetary defined aggressive response options maintained fixed ratio schedules consequences shifts response rates time distributions observed aggressive response option following oxytocin doses relative placebo changes observed monetary reinforced responding however across participants direction magnitude changes aggressive responding systematically related dose trends observed psychometric physiological data oxytocin dosing aggressive behavior report knowledge first examine acute effects oxytocin population high risk violence forms antisocial behavior several limitations experimental design results cast study preliminary report strategies extensive future projects discussed
recently growing interest interaction schizophrenia spectrum disorders substance use disorders sud condition named dual schizophrenia spectrum disorders previous research focused clinical cognitive aspects little known impact comorbidity brain structure functions evidence suggests dual diagnosis patients including show better neurocognitive functioning first years illness followed serious long term decline initial search retrieved articles excluded redundant fulfilling selection criteria thirty three structural functional neuroimaging studies compare patients included groups exhibited brain alterations comparison sud patients healthy controls patients less cognitively emotionally impaired non dual worse healthy controls neurobiological alterations prominent five years illness longer moreover sud characteristics important modulating factors contrary clinical severity specific diagnosis elsevier ltd rights reserved
paper novel mixed iterative adaptive dynamic programming adp algorithm developed solve optimal battery energy management control problem smart residential microgrid systems based data load electricity rate two iterations constructed iteration iteration respectively iteration implemented based value iteration aims obtain iterative control law sequence period iteration implemented based policy iteration updates iterative value function according iterative control law sequence properties developed mixed iterative adp algorithm analyzed shown iterative value function solution equation iteration proven performance index function finite iterative control law sequence finally numerical results comparisons given illustrate performance developed algorithm
self anchored suspension bridges fabrication subjected live loads new deflection theory formulated optimized initial state solution found dead loads analytical solution three span continuous suspension bridges consistently derived considering tower effects compared derived conventional deflection theory earth anchored bridges hand length method keeps element lengths constant nonlinear iteration process extended applied nonlinear finite element analysis suspension bridges live loads finally earth anchored self anchored bridge examples analytically numerically solved using two methods numerical results compared verify accuracy effectiveness proposed deflection theory american society civil engineers
nowadays marine propulsion systems mainly based internal combustion diesel engines despite fact number lng carriers steam propulsion plants plants steam turbines used ship propulsion also electrical power generation main feed water pump drive marine generators steam turbine main feed water pump drive investigated analyzed lng carrier steam propulsion plant measurements various operating parameters performed obtained data used energy exergy analysis measurements calculations performed ship acceleration analysis shows energy exergy efficiencies analyzed low power turbines vary significantly lower comparison high power steam turbines ambient temperature low impact exergy efficiency analyzed turbines change ambient temperature degrees causes less change exergy efficiency highest exergy efficiencies achieved lowest observed ambient temperature also highest efficiencies achieved maximum developed power highest efficiencies steam turbine main feed water pump drive achieved maximum turbine developed power replacing existing steam turbine main feed water pump drive electric motor increase generator energy exergy efficiencies least analyzed operating points elsevier ltd rights reserved
objective experiment conducted determine relationship regulation methods previous work constructed skin cdna library isolated full length cdna clone termed basis conducted series bioinformatics analysis tissue distribution mrna performed using semi quantitative reverse transcription polymerase chain reaction pcr analysis expression mrna primary secondary hair performed using real time pcr real time polymerase chain reaction analysis expression location mrna primary secondary hair performed using situ hybridization results bioinformatics analysis showed gene encodes putative amino acid protein exhibited high content cysteine serine threonine gland structural domain secondary structure prediction revealed high proportion random coils semi quantitative pcr showed gene expressed heart skin liver expressed spleen lung kidney real time pcr results showed expression higher expression primary hair however secondary hair significantly higher expression moreover gene strong expression inner root hair matrix lower expression hair conclusion conclude gene play important role regulating fiber diameter
paper presents design compact ghz phase provides bit digital phase control degrees phase range beam forming systems phase designed using proposed cross coupled type topology switched reflective type topology topologies analyzed using small signal equivalent circuit model furthermore design equations derived investigated validate theoretical analysis ghz bit degrees phase designed commercial cmos technology fabricated degrees phase features good performance phase states ghz rms phase error degrees total insertion loss rms gain error better power consumption almost zero best knowledge designed degrees phase size smallest bit passive phase frequencies around ghz
properties granular materials molecular structures often studied simple geometric model set simultaneously change size constant speed topological properties empty space outside also change capturing changes subsequent classification reveal useful information model already solved size approximate solution reported different sizes solutions work complexes derived dual structure ordinary diagram ball centers use mathematical concept homology groups different appropriate use weighted diagram also known diagram instead ordinary diagram dual structure longer complex previous approaches used directly paper method proposed overcome problem method works edges vertices instead dual structure additional bridge edges introduced overcome cases output tree graph events created merged simulated graph filtered according criteria get concise information development empty space model
vegetables waste generally utilized process municipal sites open land emitting causing health hazards presents study deals alternative way utilize solid vegetable waste route energy recovery subsequent power generation diameter produced four different types vegetable waste bulk density produced increased times higher density dried vegetable waste loose form lower heating value ranged depending type vegetable waste carried open core resulted value temperature degrees degrees spark ignition internal combustion engine run generate maximum load cold gas efficiency hot gas efficiency measured respectively energy recovery organic vegetable waste possible conversion route subsequent recovery fuel small scale power generation
objective evaluate efficacy safety short wave therapy sham intervention management patients knee osteoarthritis methods searched following databases inception october medline central embase physiotherapy evidence database cinahl studies included randomized controlled trials compared sham intervention patients knee osteoarthritis results calculated via standardized mean difference risk ratio continuous variables outcomes variables respectively heterogeneity explored test inverse variance random effects analysis applied studies results eight trials patients met inclusion criteria effect short wave therapy pain found positive pain subgroup showed patients received pulse modality achieved clinical improvement pain scale female patients decreased terms strength short wave therapy superior control group significant difference physical function adverse effects significant difference treatment control group conclusion short wave therapy beneficial pain caused knee osteoarthritis pulse modality seems superior continuous modality knee muscle combining strength function improved
catalyze reversible production hydrogen gas electrons mechanism catalysis still subject debate report describe pre steady state methodology correlating putative intermediates reactivity method rapidly formed pulsed laser excitation active site dynamics followed time resolved visible infrared spectroscopy respectively results validate red intermediates strongly supporting vast body literature involvement proton reduction
paper used agent instead melt method used polypropylene flame nanocomposites structure property products characterised ray diffraction fourier transform infrared spectroscopy transmission electron microscopy thermogravimetric analysis tga cone test limiting oxygen index vertical burning test results showed polymer chain dispersed matrix form get texture appropriate content composition mass use increased tensile strength materials impact strength improved flame properties tga showed residue rate reached cone experiments indicated peak heat release rate reduced comparison pure residue weight increased vertical burning test results indicated materials achieved grade
offer seasonal affective disorder hypothesis explain variations daily returns stock indices examine new variable called sad onset recovery analysis reveals concerns validity sad hypothesis elsevier inc rights reserved
thrombocytopenia myelofibrosis renal dysfunction syndrome atypical manifestation disease however mechanism underlying rare syndrome remains unknown established standard treatment report cases two young females syndrome showed similar clinical courses cases showed severe thrombocytopenia although high dose steroids ineffective combination chemotherapy showed remarkable effects however patients developed severe reversible heart failure therapy owing diffuse cardiomyopathy presumably associated syndrome therefore although combination chemotherapy effective treatment syndrome careful observation cardiomyopathy development needed particularly using containing regimens
improve insulin resistance endothelial dysfunction however mechanisms underlying effects remain fully elucidated present study aimed examine molecular mechanism anti effects response mouse treated hours induced assessed wire results showed attenuated induced contraction mouse effect abolished receptor antagonist synthase inhibitor removal endothelium using northern blotting real time pcr western blotting immunohistochemical techniques found upregulated expression mrna protein levels mouse human vascular endothelial cells induction prevented activated receptor gamma luciferase reporter assay showed enhanced gene promoter activity furthermore chromatin immunoprecipitation assays demonstrated activated receptor gamma directly bind gene promoter furthermore vivo treatment also attenuated induced increased expression mouse arteries conclusion results demonstrate attenuated induced upregulation endothelial activated receptor gamma direct target hypertension
study objectives evaluate novel sleep education program low income preschool children families design randomized trial educational intervention setting community based participants head start preschool families greater interventions classrooms head start sites randomized intervention group prompt intervention versus control group delayed intervention parents attended one time min sleep education program preschoolers received total min classroom sleep curriculum measurements parent knowledge attitudes self efficacy beliefs assessed primary outcomes just min sleep intervention immediately approximately parents reported childs wake times day sleep diaries baseline follow average sleep durations served secondary outcomes results linear mixed models showed time treatment effect parents knowledge attitudes self efficacy beliefs improvements found immediately retained follow children intervention group improved sleep duration follow min hours baseline compared controls versus baseline difference groups children show statistically significant improvements conclusions educational interventions early childhood effect parents sleep knowledge attitudes self efficacy childrens sleep behavior however repeated exposure new information important parents children
paper propose algebraic language called time dedicated express bdi agent plans according features requirements ambient intelligence ami systems plan expressions written composed using time plans built automatically fly system concurrent processes language describes time dependent behavior agent provides theoretical foundation performing planning timing constraints taking account duration actions also allows express behavioral capabilities communication mobility cooperation context show achieve powerful mechanism contextual guidance based specific formal construction called contextual time planning system
objective purpose present prospective cohort study monitor urine samples recipients renal search occurrence cells inclusion bearing cells aim correlate existence cells molecular detection dna urine material methods study included patients underwent renal transplantation patients urine tested first year post transplantation presence cells cells quantitative determination load urine plasma results three hundred sixty one examinations performed patients within months attendance urine results negative positive presence viral effects depending presence infection positive manifestation cells unsatisfactory analysis subtle tendency towards presence inclusion bearing cells cases virus detected urine however presence cells exhibited tendency positivity months exclusively month trend statistically significant conclusions enough strong morphological staining elements state origin cells describe nature infection viral bacterial given cells undergoing apoptotic process post renal transplant patients
study evaluates utility dna mitochondrial cytochrome oxidase subunit biodiversity conservation applied tool identifying fish southeastern mediterranean coast hot spot area biological invasion also eye establish foundation follow studies use environmental dna tracks native invasive species application concepts methodologies nature conservation established dataset dna representing marine fish species identified belonging native migratory species tested within system database query sequences showed matches reference dna system excluding two species three two individuals relatively high genetic distances observed two species suggesting possible species contrast relatively low genetic distances found two species family members observed scattered bayesian tree fish species discordant family level genus level species level concordant noted species analysis system first time elucidated haplotypes native fish species species results allow evaluation invasive species success help developing improved policies conservation mediterranean biodiversity elsevier gmbh rights reserved
web based knowledge database computing platform nonlinear differential equations presented provide computing based symbolic computing system maple built packages users calculate specific types analytical solutions nonlinear differential systems calling packages also carry symbolic computations associated equations kinds simple computations interactive mode visual output knowledge database differential equations functions general database furthermore equation web page show properties research results addition formula stored form knowledge database displayed visually
despite increasing use portable tablets learning impact received little attention research five different projects media ethnographic design based analysis use portable tablets learning resource science investigates young peoples learning portable tablets matches intentions applying media information literacy components analytical dimensions pattern discrepancies young peoples expectations actual learning approaches framing learning identified argued paradoxically decisions introducing new technologies portable tablets new support conflict many young peoples traditional ideas learning assessment implications integration portable tablets indicates making pedagogical transformations accommodate new technologies risk opposing didactic intention sufficiently attend young learners systemic expectations learning expectations digital experience influenced leisure use
smart meter key part smart grid responsible collecting user characteristics advanced infrastructure applications protocol potentially replace standard protocol internet things area representing application technology smart article introduces design electricity information acquisition module transmitter receiver embedded module set data transmission based individual system tests advanced module shown robustness interference immunity high network stability lower power consumption comparing modules different hardware operating systems
strength materials mechanics bodies part mechanics deals study relationship internal forces deformations arising real bodies changes shape size relation loads acting linkages physical properties material made general resistance materials engineering provides foundation allow together conditions stability balance calculate project work elements machines determining size verifying designed suitable proposed objectives distinguish two perspectives scope subject firstly problem sizing secondly checking study scientific technological areas characteristic providing practical results gives students opportunity test usefulness course solving everyday problems practice engineering important teacher uses obtain maximum attention interest students study strength materials done isolation rely knowledge mechanics related study elasticity difference theory elasticity strength materials primarily focusing problem theory elasticity based accurate approaches means simplified assumptions adopted strength materials subject elasticity strength materials usually given middle years degree subject engineering degrees architecture etc subject assumptions simplify every problem sometimes lack practical experiments support accuracy theoretical analysis provoke insecurity lack student motivation lack critical thinking essential engineer remedy lack motivation insecurity critical propose creation working group work analyze stress state real piece comparing results three methods analysis first method theoretical analysis second third experimental analysis numerical analysis variation results obtained method promote discussion analysis reasons results choice piece important complex piece beyond bounds subject simple piece produce significant variation results teaching experiment performed participation four teams groups student volunteers test whether introduction work subject generates positive educational outcome conducted student survey focusing three aspects acquisition knowledge increased motivation importance course future engineer survey provided different results students participated project students took part part analysis felt able discuss real part subject others much less understanding subject students surveys teaching real life problems give impression achieved main objectives
objective systematic review identify current computer assisted technologies used managing patients need establish appearance subjective discomfort function extent clinical documentation electronic search strategies used locating clinical studies medline pubmed cochrane library grey literature searches google scholar searches commercial digital products use oral rehabilitation resulted identifying products per november used patient diagnostics communication therapy purposes computer assisted applications context oral rehabilitation one third products described papers reporting clinical human studies great majority digital products use oral rehabilitation clinical documentation products distinct minority manufacturers frequently appeared less scientific reports law apply also digital predicts capacity continue become faster lower cost per performance unit innovative software programs harness improvements performance net effect noticeable short product life cycle digital products developed use oral rehabilitation often lack supportive clinical documentation nonetheless clinicians request clinically meaningful information new digital products assess net benefits patients dental professionals accept technological basis product
aims seek feedback clinical experiences specialty training applicable transition working national health service materials methods clinical gaining completion training july june identified records held royal college radiologists approached take part online survey results survey completed clinical invited take part response rate respondents agreed specialty training equipped clinical skills radiotherapy planning systemic therapy tumour site diagnosis treatment fell advanced radiotherapy techniques non clinical skills respondents felt training equipped less deal leadership management research clinical governance despite respondents undertake programme activity gain new skills respondents undertake activity agreed helped prepare first post broad support examination first examination modules physics pharmacology tumour biology seen relevant clinical practice respondents final examination seen essential technical specialty like clinical oncology respondents working new survey revealed heavy workload respondents always almost always working beyond hours issues concern identified discrepancies job plans job plan review process transition often difficult time yet respondents allocated formal respondents rely informal arrangements seeking support advice medical colleagues conclusions general respondents satisfied specialty training transition training working new areas possible improvement identified involved specialty training royal college radiologists published elsevier ltd rights reserved
paper presents photovoltaic system maximum power point tracking facility goal work maximize power extraction photovoltaic generator goal achieved using sliding mode controller smc drives boost converter connected load system modeled tested matlab simulink environment simulation sliding mode controller offers fast accurate convergence maximum power operating point outperforms known perturbation observation method sliding mode controller performance evaluated steady state load varying panel partial shadow disturbances confirm conclusion practical implementation maximum power point tracker based sliding mode controller hardware setup performed real time digital control platform data acquisition control system conducted around controller board environment experimental results demonstrate validity proposed control scheme stand alone real photovoltaic system elsevier ltd rights reserved
plant irradiation period using environmental low level microwave radiation known alters plant growing process order analyze subtle effect generated microwave irradiation environmental parameters light temperature humidity kept identical reference irradiated lot difficult task humidity temperature interrelated order study plant behavior low power irradiation paper describes design manufacturing operating process device performances plant growth end low power microwave field average power density controlled environmental parameters used device consists reference chamber microwave irradiation chamber volume one equipped access irradiation chamber ensures microwave field distribution programmable power frequency bandwidth commonly used standards network communication global system mobile communications code division multiple access third generation mobile technology ghz wireless local area network provide least toward outside interfere inner environment equipped performing temperature humidity sensors controlled led lighting system maximum mol uniformity mol measured bottom level chamber embedded system microcontroller measures temperature humidity proceeds continuously match humidity pair less relative humidity difference using low flux exhaust ventilation process simple innovative method accuracy temperature measurement better degrees humidity temperature data set programmable acquisition rate whole experiment read later personal computer identify influence microwave treatment seeds plants development three growing experiments based seeds number seeds determined day days experiment energy seeds length stems roots index dry matter content measured computed obtained data showed significant increase parameters microwave irradiation condition elsevier rights reserved
although construction industry major component economy suffering declining productivity decades human element project managers particular key solving problems measurement overall performance important identify training needs enables better match competent appropriate projects paper provides construction industry generic mathematical formulation reliably different competencies developed data driven mathematical model reflects relative importance industry practitioners place different competencies distinguishing exceptional average ones developed model applied data set assessments filled selected rated exceptional average results presented paper suggest focus developing cognitive side rather settling possessing adequate knowledge experience managerial skills leadership capabilities also quantitative results illustrate business financial disciplinary understanding phases construction projects continuous monitoring similar construction projects consistent awareness available information technologies among distinguishing competencies exceptional average results assist construction industry directing efforts toward accurately identified leverage development areas actual training educational needs additionally paper compares results developed data driven mathematical model existing expert evaluation presenting key step revealing turn reducing experts
multidisciplinary rehabilitation beneficial effects health related quality life hrqol patients chronic rheumatic diseases however whether intervention benefits different age groups women men largely unknown investigate hrqol patients chronic rheumatic disease completion week multidisciplinary treatment special focus differences effect age gender groups hrqol measured mean scores domains compared week regimen month follow ups multivariable linear regression models using generalized estimating equations account repeated measurement employed weighting procedure account differential applied three hundred fifty six women men chronic rheumatic disease included short term improvements domains irrespective age gender effects persisted year psychological social energy domains women found lasting effects men however young men showed similar trends inpatient multidisciplinary rehabilitation improves short term hrqol patients younger women maintain beneficial effects year additional intervention considered elderly women men order sustain rehabilitation effects
recent advent induced pluripotent stem cells enabled study patient specific disease related neurons vitro facilitated new directions inquiry disease mechanisms approaches now possibility correlating vivo cellular phenotypes individual patient response treatment side effects makes targeted treatments schizophrenia bipolar disorder distinct prospect coming years briefly review current state stem cell based models explore studies providing new insights disease biology schizophrenia bipolar disorder foundations development novel targeted therapies
middle east respiratory syndrome emerged saudi arabia caused transmitted cases reported date similar rate lack cases hindered understanding pathogenesis small animal model develops progressive pulmonary manifestations infected advance field mice restricted infection level receptor generated mice humanized exons mouse locus upon inoculation human mice supported virus replication lungs developed illness serial lungs mice mouse adapted virus emerged grew lungs times higher titers starting virus plaque purified clone caused weight loss fatal infection virus antigen observed airway macrophages pathologic findings included diffuse alveolar damage pulmonary edema membrane formation associated accumulation activated inflammatory monocyte macrophages neutrophils lungs relative parental viruses contained mutations including several within glycoprotein gene protein mutations sensitized viruses entry activating serine proteases conferred rapid entry kinetics recombinant bearing mutant proteins virulent parental virus mice mouse provide tools investigate disease causes develop new therapies
prospective week open label trial evaluates tolerability efficacy treatment core social cognitive deficits adults high functioning autism spectrum disorder asd measures assessment therapeutic response included social responsiveness scale adult research version disorder specific clinical global impression scales behavior rating inventory executive functioning adult self report diagnostic analysis nonverbal accuracy scale neuropsychological test automated battery eighteen adults mean age years high functioning asd raw score treated mean dose range completed trial treatment associated significant reduction informant rated clinician rated clinical global impression improvement subscale measures autism severity addition treatment associated significant improvement adhd anxiety symptom severity significant improvement noted nonverbal communication diagnostic analysis nonverbal accuracy scale test executive function per self report behavior rating inventory executive functioning adult self report global executive composite neuropsychological assessments neuropsychological test automated battery treatment generally tolerated associated serious adverse events treatment appears beneficial treatment asd associated psychopathology cognitive dysfunction capable adults future placebo controlled trials warranted
purpose study identify factors influence undergraduate college student use emergency contraception level knowledge product order assist development intervention programmes increase use lead lower rates unintended pregnancies population response rate included surveys students universities students predominantly female white aged years ranged first year students students second year students comprising largest group majority respondents reported heterosexual completing questionnaire reported committed relationship respondents reported sexual intercourse least lifetime sexually active students experienced unintended pregnancy used past months knowledge high knowledge increased use increased integrated behavioural model predicted variance intention construct contributed portion variance except experiential attitude statistically significant path analysis model used future interventions increase use decrease unintended pregnancies among college students
violence exposure negatively impact early childhood development yet limited research exists low middle income countries study aimed determine effective integration plus violence prevention look like seventeen key informants selected using sampling representing agencies donors research organisations using open coding semi structured interviews authors identify five priority areas promoting integrated agenda parenting parent child relationships family systems iii development ecological context system strengthening integration building translating evidence john wiley sons ltd national childrens
purpose lower urinary tract symptoms common united states population leading significant economic quality life public health issues burden increase population ages risk factors lower urinary tract symptoms including diabetes obesity remain highly prevalent improving clinical management establishing knowledge base prevent lower urinary tract symptoms require comprehensive research approach examines factors beyond lower urinary tract study extra lower urinary tract factors increased recently current research systematically account broad set potential contributing factors spanning biological behavioral psychological executive function sociocultural factors comprehensive assessment potential contributors risk treatment response progression necessary reduce burden condition united states materials methods considered challenges continuing predominantly lower urinary tract dysfunction centric approach dominated previous research lower urinary tract symptoms results developed new comprehensive framework research includes broader set potential factors contributing lower urinary tract symptoms framework aims broaden research consider comprehensive set potential contributing factors engage broad range researchers investigation many extra lower urinary tract factors possible goal improving clinical care prevention conclusions propose new framework future research help reduce medical economic burden lower urinary tract symptoms united states population
article examines british national party opposition gay men drawing concept examines written material publications decades looking specifically aids crisis belief role played decline national front birth first study dedicated british anti gay prejudice article argues existing scholarship fails understand degree nature anti gay party inception
biotechnological production fatty important raw materials chemical industry receiving considerable attention recent years fatty formed reduction fatty acyl fatty acyl catalyzed fatty acyl reductase far study introduced genes encoding arabidopsis thaliana roots via agrobacterium mediated transformation efficiency transformation ranged fatty detected transgenic root lines expressing gene tested lines alcohol alcohol alcohol produced content varied total fatty acids fatty amount either exceed transgenic root lines produced fatty per dry weight low activity detected fractions isolated selected root lines knowledge first report fatty alcohol production root cultures wiley periodicals inc
mitochondrial dysfunction implicated pathological mechanism alzheimers disease amyloid beta protein beta plays central role pathogenesis reported accumulate within mitochondria however question remains whether beta generated locally amyloid precursor protein app within mitochondria investigated issue analyzing expression patterns app app processing app metabolites mitochondria separated human neuroblastoma cells expressing swedish mutant app protein levels significantly lower crude mitochondria fractions gamma complex components comparable fractions crude mitochondrial fraction containing substantial levels lysosomal marker separated via gradient obtain mitochondria enriched fractions mature app gamma complex components particular present mitochondria enriched fraction compared enriched fraction moreover expression beta terminal fragment beta app markedly low mitochondria enriched fraction additionally analysis showed little localization marker protein mitochondria view particularly low expression levels gamma complex proteins beta mitochondria propose unlikely beta generation app occurs locally within elsevier inc rights reserved
attractiveness magnesium alloys structural applications caused intrinsic properties low density high specific strength main challenge development magnesium alloys connected requirement fulfill main function structural materials bear load magnesium alloys possess strong basal texture causes anisotropy mechanical properties interesting find way benefit anisotropic behavior magnesium alloys one way take account strong basal texture magnesium alloys compressive deformation samples magnesium alloy successively deformed compression strain along two perpendicular directions first compression sample contracts along direction parallel compression axis one perpendicular direction deformation observed third perpendicular direction subsequent compression along direction initial shape sample microstructure analyses shows main deformation mode compression along direction twin variants gives strain direction predominant microstructure microstructure observed subsequent compression along direction analyzes calculations explain reversible motion twin boundaries favorable twin variants matrix grains compression along direction experiment presented article profile magnesium alloy smart material emphasize importance strong texture obtaining properties characteristic smart materials presented case ability produce recover significant strains controlled manner compressive stress elsevier ltd rights reserved
study conducted provide fundamental data distribution concentrations child day care facilities south korea help establish mitigation strategies study child care centers randomly chosen child care centers nationwide alpha track detectors used examine cumulative exposure concentrations january mean concentration measured korean child care centers approximately one third upper limit recommended south indoor air quality control public use facilities etc act environmental protection agency epa furthermore concentration lower measured concentration houses nationwide december february results indicate amount ventilation major determining factor indoor concentrations strongly correlated fluctuation indoor concentrations korean child care centers elsevier ltd rights reserved
based aggression theories previous researches examined effects viewing violent movie via computer aggressiveness among college students total females undergraduates participated study distributed violent movie group allocated non violent movie group results indicated aggressiveness violent movie group non violent movie group significantly strengthened moreover aggressiveness males females significantly enhanced among violent movie group instead non violent movie group aggressiveness viewers high aggression low aggression significantly enhanced among violent movie group instead non violent movie group males viewers violent movie significantly aggressiveness indicating gender aggressive level responsible aggressiveness among college students implications findings discussed elsevier ltd rights reserved
beta activate innate immune responses major component cell wall form current study examined whether beta surface proteins role beta play associated inflammation species including causes pneumonia humans beta organisms demonstrated increased exposure following treatment using quantitative polymerase chain reaction microarray techniques demonstrated mouse model pneumonia treatment inhibitor beta synthesis days decreased expression broad panel inflammatory markers including interferon gamma tumor necrosis factor alpha interleukin beta interleukin multiple chemokines chemokine ligands thus beta largely likely decreases innate immune activation mechanism presumably developed interactions hosts organism loads substantially lower hosts high organism burden organism death release appears important contributor deleterious host inflammatory responses
associated reduced male reproductive potential advances techniques possible better understand mechanisms involved testicular damage current evidence suggests central role reactive oxygen species ros resultant oxidative stress pathogenesis associated male although mechanisms yet fully described likely multifactorial excessive ros associated sperm dna fragmentation mediate clinical manifestation poor sperm function fertilization outcome related testing ros dna fragmentation potential provide additional diagnostic prognostic information compared conventional analysis guide therapeutic management strategies individual patient
key success company business ability succeed global rapidly changing labour market achieved workforce qualified skilled flexible thus clear emphasis also put staff development development achieved many ways one lifelong learning supported universities paper presents learning study materials developed academics department machine design faculty mechanical engineering university west study materials focus design projects industrial practice several projects one focuses specific machine outputs projects learning files study materials contain important information designer usually comes contact example drawing documentation model calculation reports welding technology etc study materials developed primarily full time students department machine design lack practical knowledge project completed became clear study materials also applied context lifelong learning institute lifelong learning university west offers courses training companies general public courses employees tend focused area specified company public courses designed training individuals open courses periodically arranged spring autumn year train groups due narrow specialization engineers work industrial practice loss continuity education areas mechanical engineering study materials comprehensive include knowledge different fields engineering new job study materials help employee study starting work another field possibly even shorten company learning study materials also help large extent job interview study materials created cooperation experts industry according currently valid technical standards
year american centers medicare medicaid cms graduate medical billion graduate medical education usa now education lack evidence based research effectiveness learner centered learn taught outcomes based delivery system education proven important tool measuring status graduate medical competency based education america competency based medical education medical education shown important part international medical education system since teaching american council graduate medical education started measuring six core competencies decade ago questions regarding traditional training methods benefits since single system american association put effect july now best time community nationally internationally take look teaching residents within article faculty training residents reflective practices assessment specifically focused utmost importance research medical education curriculum able help meet needs future generations also competent globally engaged professional physicians article seeks show need innovation role competency based medical education play profession meet need elsevier ltd rights reserved
background aimed evaluate potential benefits leadership coaching health program physical activity dietary habits distress management cancer survivors methods randomly assigned cancer survivors allocation ratio two one program group long term survivors usual care group baseline months used scores intake vegetables fruits post traumatic growth inventory primary outcomes secondary outcomes ten rules highly effective health behavior quality life qol hospital anxiety depression scale european organization research treatment cancer quality life questionnaire results primary outcomes two groups significantly differ scores intake differed marginally secondary outcomes group showed significantly greater improvement anxiety score social functioning score appetite loss financial difficulties scores scales baseline months baseline months group showed significantly greater decrease fatigue score significantly greater increase number ten rules highly effective health behavior conclusion findings indicate program long term survivors provide effective management qol cancer survivors dietary habits
evidence least one spatial dimension material component nanometer range effects stress inclusions pores cracks either eliminated significantly reduced aim paper examine evidence using simulation techniques crystalline metal identify critical dimensions effects minimal even preliminary results reported herein show single crystals subjected constant external strain rate critical dimensions larger since details crucial understanding material behavior scales paper points need multiscale simulations techniques presently developed identifying critical dimensions examining slow strain rates based results paper presents simulation based explanations insignificant elsevier ltd rights reserved
study examined usefulness statistical parametric mapping investigating postmortem changes brain computed tomography retrospective study included patients years old without cerebral abnormalities underwent brain death scans postmortem scans spatially normalized using original brain template postmortem changes values units analysed technique compared scans scans showed loss cerebral unclear grey matter white matter interface respectively analysis revealed significant decrease cortical density within min death scans suggesting cytotoxic brain furthermore significant increase density nucleus thalamus min death technique demonstrated typical postmortem changes brain scans revealed unclear interface early scans caused rapid decrease cortical density combined delayed increase density useful assessment whole brain postmortem changes cent original brain template achieved successful normalization brain morphology cent postmortem changes brain independent sex cent cortical density decreased rapidly death cent deep densities increased following cortical density change cent useful assessment whole brain postmortem changes
purpose aim present study examine relationship peripheral bone marrow levels characteristics laboratory parameters myeloproliferative disease patients patients methods total patients enrolled study examined relationship bone marrow peripheral levels patients laboratory parameters results significant correlations peripheral levels jak mutation thrombosis white blood cells lactate dehydrogenase ldh saturation bone marrow addition significant correlations bone marrow levels jak mutation thrombosis ldh bone marrow identify significant relationship peripheral bone marrow levels however significant correlations peripheral levels bone marrow fibrosis bone marrow levels constitutional symptoms bone marrow levels bone marrow fibrosis conclusion find significant relationship laboratory characteristics peripheral bone marrow cells bone marrow fibrosis patients also significant relationship bone marrow cells peripheral cells peripheral cells originate spleen rather bone marrow given different result parameters
regional labour force participation across european union time space recursive modelling approach endogenous spatial economic analysis although abundant regional labour market literature taking spatial perspective studies explored extending analysis labour force participation spatial effects paper important issue proposing time space recursive modelling approach builds methodology finding united states participation rates vary past values nearby regions major shortcomings study corrected including control endogenous time space time lagged dependent variable using system generalized method moments paper also highlights interaction effects among explanatory variables first time context using panel regions across european union results total male female participation rates new light socio economic relevance different determinants importantly characteristics regions play significant role found serious consequences increased attention specification estimation spatial models endogenous
introduction maternal obesity shown risk factor obesity children also affect childrens psychosocial outcomes yet clear whether also psycho emotional mechanisms explaining effects maternal weight young childrens weight psychosocial development aimed evaluate whether maternal body mass index bmi mother child emotional availability maternal parenting stress associated childrens weight psychosocial development internalizing externalizing symptoms social competence whether predictors interact methods longitudinal study included three assessment points similar months apart baseline sample consisted mothers children aged months girls measured maternal weight height calculate maternal bmi mother child interactions coding scales fourth edition assessed maternal parenting stress parenting stress index psi short form measured height weight children calculated bmi sds scores childrens externalizing internalizing problems social competence assessed using questionnaires child behavior checklist strengths difficulties questionnaire prosocial behavior checklist behavioral problems preschool age social emotional competence results applying structural equation modeling sem latent regression analysis found maternal bmi predict higher bmi sds poorer psychosocial development higher externalizing symptoms lower social competence children higher parenting stress predicted higher levels externalizing internalizing symptoms lower social competence better maternal associated higher social competence found parenting stress serve mediator association maternal weight childrens psychosocial outcomes moreover children mothers elevated bmi greater risk lower social competence mothers showed low levels maternal moderation conclusion interventional studies needed investigate causal pathways parenting stress mother child interaction quality child outcomes aspects targets improve psychosocial development offspring overweight obese mothers
reported water energy two biggest development human health challenges present study presented risk potential index model source vector transport target risks forecasting surface water contamination main aim model identify critical surface water risk zones open cast mining environment taking india study area model also helps feasible sampling design based spatial analysis various risk zones successfully delineated monthly distribution revealed risk surface water contamination highest months surface water samples analysed validate model gis based alternative management option proposed reduce surface water contamination risk observed decrease spatial distribution high risk areas months june july respectively elsevier ltd rights reserved
ascorbic acid dopamine uric acid tryptophan considered crucial small biomolecules physiological processes human metabolism abnormal levels species lead occurrence diseases disorders paper covalent functionalized graphene used modify carbon electrode applied simultaneous sensitive determination four molecules nanocomposite characterized fourier transform infrared spectroscopy ftir ultraviolet visible vis ray powder diffraction xrd transmission electron microscopy tem electrochemical behaviors modified electrode studied detail optimal experimental conditions simultaneous determination explored results showed oxidation peaks four species separated peak peak respectively linear response ranges simultaneous detection mol mol mol mol detection limits mol mol mol mol respectively proposed method provides promising strategy simultaneous detection species practical application
angioedema episodic swelling deep tissue due increase local vascular permeability swelling involve skin respiratory gastrointestinal tracts commonly involved areas region report case fatal laryngeal obstruction due angioedema likely caused angiotensin converting enzyme inhibitor year old man witnessed developing sudden facial swelling acute respiratory difficulties quickly followed past medical history suggested second episode angioedema without urticaria postmortem examination revealed complete laryngeal obstruction absence infection neoplasm autoimmune disease postmortem computed tomography head neck showed complete obstruction upper airway based current understanding pathophysiology different types angioedema suggest angioedema without urticaria forensic setting offer readers resources use practice
buildings major consumers energy hong kong urban areas world building environmental assessment schemes green building rating tools adopted architects engineers researchers years help promote sustainable construction activities rating tool highlights energy use significant portion assessment provides guidance energy efficient strategies building energy efficiency usually improved passive active technologies active design involves making energy efficient heating ventilation air conditioning systems hot water production lighting building services application whereas passive design focuses building envelope related aspects determined architectural design reduce demand building energy recently renewed interest passive strategies low extra investment potential benefits energy saving passive design approach also recognized latest versions green building rating tools five representative rating systems developed passive design criteria leading credits subject comparative examinations respect effectiveness accuracy criterion paper passive design criteria including building layout envelope building geometry air infiltration performance effects building energy consumption also comprehensively reviewed results show holistic design approach based passive energy saving strategies proves effective way reduce building energy however consolidated weighting systems enable comparison different passive strategies incorporated green building rating tools based sensitivity parametric studies elsevier ltd rights reserved
develop experimental multi domain interventions older people mild moderate dementia evaluate effect delaying cognitive physical decline improvement prevention geriatric syndromes year follow aged older mild moderate dementia clinical dementia rating grouped intervention veterans home usual care model community memory clinic residents veterans home received comprehensive intervention including multi disciplinary team consultation intervention multi component non pharmacological management geriatric syndromes survey intervention dementia friendly medical green channel approach decline cognitive physical function determined change mini mental state examination score sum box activities daily living based index also screened geriatric syndromes baseline later intervention group older lower educational level lower body mass index poor baseline activities daily living function lower visual impairment higher rates hearing impairment risk malnutrition residents receiving lower baseline mini mental state examination scores higher residents veterans home cognitive measurements except mini mental state examination significantly associated delaying decline cognition analyzing multiple linear regression multivariate logistic regression also showed patients living community independently associated higher odds ratio activities daily living decline also improvement baseline geriatric syndromes suffered less new geriatric syndromes including falls urinary incontinence risk malnutrition conclusionsthe intervention shows strong delays decline cognition physical function older residents mild moderate dementia furthermore strategy also improve prevent onset new geriatric syndromes especially fall episodes urinary incontinence risk malnutrition int
objective evaluate perceived quality satisfaction sex education among university new mexico college students study design survey methods utilized year old new mexico high school survey included questions type sex education satisfaction sex education point likert scale impact sexual decision making participants results total surveys returned response rate attend high school new mexico leaving surveys analytic sample comprehensive sex education received higher ratings abstinence sex education respectively students receiving comprehensive sex education abstinence education reported improved ability make decisions sexual initiation pregnancy prevention sexually transmitted infection prevention avoidance unwanted sex conclusion new mexico college students satisfied comprehensive sex education high school new mexico consider establishing state requirement corn sex education
objectives widely used industrial products persistent organic pollutants due chemical stability previous studies suggested disrupt thyroid hormone status although plays important role fetal growth pregnancy little attention paid relationships maternal exposure mothers fetuses investigated effects low levels environmental thyroid function mothers infants methods eligible subjects prospective cohort mother infant pairs selected concentration maternal serum measured samples taken second third within week delivery blood samples measuring thyroid stimulating hormone tsh free thyroxine levels obtained mothers early gestational stage median weeks infants days age respectively results median concentrations confidence interval limitation detection respectively maternal levels inversely correlated maternal serum tsh positively associated infant serum tsh whereas maternal showed significant relationship tsh among mothers infants conclusions findings suggest independently affect secretion maternal infant tsh even low levels environmental exposure
majority patients psoriasis mild moderate disease managed primary care topical therapies supportive role pharmacists patients long term dermatological conditions largely unknown objectiveto assess impact educational intervention delivered community pharmacists improve self management people psoriasis study involved pre post intervention design seven community selected based location urban rural etc pharmacists recruited via local comprehensive research networks patients mild moderate psoriasis recruited either via letter pharmacists undertook face face consultation one follow visit weeks primary outcome change person centred dermatology self care index score secondary outcomes self assessed psoriasis severity index measuring disease severity dermatology quality life index key total patients recruited weeks patients completed follow consultation significant increase mean scores versus weeks compared baseline similarly versus versus scores improved significantly assisted support patients psoriasis improved knowledge reduced disease severity impact quality life results suggest community pharmacists important role play facilitating self management patients psoriasis
objectives determine rates phase pregnancy young women initiating implants day menstrual cycle study design assessed retrospective cohort young women receiving contraceptive implants adolescent title clinic patients negative pregnancy tests eligible day insertion regardless cycle day contraceptive use last intercourse computed rates within manufacturer guidelines insertion days menstrual onset days post hormonal contraception outside guidelines reviewed medical records last menstrual period current hormonal contraception emergency contraception provision pregnancy tests weeks post implant placement later evidence pregnancy patients positive pregnancy tests reports used standard dating ultrasound determine conception occurred weeks implant placement results insertions outside recommended guidelines women insertions within guidelines older years likely white definitive pregnancy data documented patients within guidelines group outside guidelines group rates within guidelines group outside guidelines group conclusion risk following cycle day insertion contraceptive implants negative pregnancy testing low regardless menstrual cycle timing recent contraceptive use use elsevier inc rights reserved
intestine larval epithelial cells removed apoptosis adult epithelial stem cells appear concomitantly differentiate form adult epithelium thyroid hormone established trigger remodeling regulating expression various genes including notch receptor study role notch signaling analyzed expression components including ligands receptor notch targets intestine real time reverse transcription polymerase chain reaction situ hybridization immunohistochemistry show regulated natural induced tissue specific manner particularly specifically expressed cells moreover upregulation prevented treating inhibitor inhibits notch signaling importantly induced regulation adult intestinal stem cell marker suppressed treatment results suggest notch signaling plays role stem cell development regulating expression genes intestinal remodeling furthermore show organ culture experiments prolonged exposure intestine plus leads hyperplasia secretory cells reduction cells findings thus provide evidence evolutionarily conserved role notch signaling intestinal cell fate determination importantly reveal first time important role notch pathway formation adult intestinal stem cells vertebrate development
sterilization food drug administration approved united states since complications associated device include placement unintended pregnancy pain infection nickel allergy complications makes difficult determine best practices management systematic review national global experience management related complications suggests treatment options data allow rights reserved
invasion routes molecular data crucial understanding biological including identifying bottlenecks population size among distinct populations unravel invasion routes invasive pest drosophila using multi locus microsatellite dataset loci worldwide sampling locations use approximate bayesian computation abc improved reconstruction invasion routes computationally expensive use study illustrate use new efficient abc method abc random forest abc compare standard abc method abc find japan emerges probable source earliest recorded invasion southeast china together probable sources populations western north america turn served sources eastern north america european populations genetically homogeneous north american populations probable source northeast china evidence limited gene flow eastern introduced populations passed bottlenecks analyses reveal five distinct events findings inform hypotheses concerning species evolved different independent source invasive populations methodological comparisons indicate abc abc show concordant results abc based large number simulated datasets abc performs abc using comparable number simulated datasets especially analyzing complex introduction scenarios
study examined effects cognitive intervention program rational behavior therapy thoughts behaviors arising adverse childhood stress nigeria participants identified victims adverse childhood stress met criteria inclusion self report questionnaire treatment process guided adverse childhood stress management manual consists weeks full intervention weeks follow meetings study used repeated measures anova order see improvement participant across control treatment groups thoughts behaviors intervention program results show sex differences determine experience adverse childhood stress cognitive intervention program rational behavior therapy thoughts behaviors arising adverse childhood stress experience significantly reduced treatment group compared control group significant improvement also observed end intervention treatment group implication research practice discussed line outcomes finally study stressed importance follow study nigeria assess beliefs one measures ptsd symptoms emotional disturbance
purpose study describe medical record retrieval study validating claims based algorithms used identify seven adverse events special interest medicare population methodswe analyzed medicare claims women postmenopausal osteoporosis men age medicare national sample final cohorts included beneficiaries covered continuously months medicare parts enrolled medicare advantage starting follow identified beneficiaries using algorithm randomly selected women men medical record retrieval centers medicare medicaid services provided contact information requested medical records directly providers without patient contact selected beneficiaries women men requested medical records overall received requested medical records observed small differences characteristics total population compared randomly selected retrieval however differences seen selected retrieved retrieved records requested hospitals compared records requested physician offices retrieval differ sex vital status beneficiaries national medical record validation study claims based algorithms produced modest retrieval rate medical record procedures outlined paper led improved retrieval previous medical record retrieval study copyright john wiley sons ltd
background aim aim study assess efficacy safety based interferon free therapies liver transplantation recipients hepatitis virus infection recurrence methods systematic literature search conducted pubmed embase web science central cochrane library without time language limitation search strategy used transplantation sustained response weeks end treatment rate incidence serious adverse events adverse events discontinuation rate confidence intervals pooled random effects model results twenty two studies patients included meta analysis pooled rate rate higher patients mild fibrosis patients advanced fibrosis cirrhosis patients hepatitis virus genotype pooled rate pooled incidence pooled discontinuation rate adverse events conclusions based interferon free therapy effective tolerated treatment strategy patients hepatitis virus infection recurrence liver transplantation
aim limited data exist crohns disease associated small bowel adenocarcinoma large scale retrospective cohort study conducted comparing clinical features outcome associated novo method data patients small bowel adenocarcinoma gathered united states surveillance epidemiology end results cancer registry medicare linked database identified patients associated novo main outcome measures overall survival cancer specific survival results associated commonly located patients diagnosed earlier stage compared novo likely undergo surgery chemotherapy use similar patients associated better year similar difference cohorts stratified stage multivariate analysis significantly related hazard ratio surgery extent improved patients whereas chemotherapy conclusion patients associated present earlier stage patients novo receive surgery similar rates chemotherapy similar presence survival treatment
development single factor experiments employed evaluate effect adding different matrix ethanol glycerol drug skin development single factor experiments employed evaluate effect adding different matrix ethanol glycerol drug skin finally selected gel matrix methyl chosen enhancer relationship time steady percutaneous amount optimized absolute bioavailability showed pharmacokinetic study skin irritation observed skin irritation study pharmacodynamic study overactive bladder model induced rats significant effects inhibition urine output rat model last optimized displayed prolonged pharmacological responses effectively avoided metabolism difference enzyme bodies compared tablets provided one single active compound plasma reduce variability two active compounds elucidate mechanism fourier transform infrared ftir spectroscopy differential scanning dsc activation energy measurements used study routes changes stratum drug release elsevier rights reserved
background surgical method choice various movement disorders especially disease many publications showing improvement motor symptoms quality life presented little comprehensive research evaluation impact mental state psychiatric side effects object purpose study assess impact mood drive psychotic symptoms group patients methods patients treated mental state psychiatric side effects assessed use bdi rating scales evaluation performed five times period day surgery six months implantation results study showed improvement mood followed within month start stimulation manifested bdi scores reduction trend towards improvement maintained following months manic episodes appeared cases mild observed psychotic symptoms occurred patient reduction observed first days initiating stimulation persisted assessment six months implantation conclusions survey results confirm effect stimulation mood drive ability feel psychiatric side effects phase change rare mild psychotic symptoms occurred one patient medication intensive research topic required elsevier rights reserved
structural health monitoring crucial protect lives asset management classical sensors low durability low sensitivity high cost limit use development smart cement based materials construction industry important task study six different cement based mixtures designed five mixtures steel fiber inclusions three samples mixture cast cured thus samples prepared samples tested split tensile test simultaneous split tensile test electrical potential measurements conducted use split tensile test determining self sensing properties cement based composites achieved first time study correlations electrical resistance change tensile strain determined performance measures factor linearity strain sensor investigated cement based composites factors high obtained highest factor reported literature factor cement based composite almost times factor metal strain factor variations electrical resistance factor linearity correlation coefficient best fit line electrical resistance change versus strain data respect fiber volume fraction discussed observations encouraging research development smart cement based materials sense strain damage elsevier ltd rights reserved
clinical decisions sometimes based variety patients information age weight information extracted image among others depending nature disease anatomy clinicians base decisions different image like positron emission tomography scans magnetic resonance images however analysis far trivial task years use image descriptors computational algorithms present summarized description image regions became important tool assist clinician tasks paper presents overview use image descriptors healthcare contexts attending different image making review analyzed studies related application image descriptors different intensity texture shape medical image analysis four imaging modalities featured pet mri pathologies typically covered modalities addressed breast masses head neck cancer alzheimers disease case pet images lung nodules regarding multiple sclerosis brain tumors mri section
background analogue based therapy important treatment option patients advanced neuroendocrine tumours overexpressing receptors addition kidneys bone marrow major dose limiting organ correlation developed toxicity absorbed dose bone marrow poor indicates factors affect response spleen important role system including reservoir blood cells also organ receives highest mean absorbed dose treatment aim study analyse mean absorbed dose spleen correlation toxicity explore changes volume study included patients treated two five occasions following fraction planar whole body scans acquired post injection mean absorbed spleen dose calculated utilising planar images time activity data adjust activity amounts volume information collected diagnostic scans baseline follow results median total absorbed spleen doses estimated respectively total absorbed spleen dose correlated decrease counts patients without bone metastases mean absorbed spleen dose correlated decrease counts spleen volume reduced original values mean months conclusions toxicity according counts moderately significantly correlated total absorbed spleen dose supports possibility radiation exposure spleen affects overall response treatment
characteristic bodily composition physical exercise seem associated perception body image non probabilistic sample users city genders years age studied relationship physical exercise non experimental association study model applied also anthropometric measurement taken including fat percentage according equation frequency length physical information measure self report results disclose measures weight height body mass index body fat percentage significantly correlated perception satisfaction physical exercise yield significant correlations categories perception satisfaction gender differences described women significantly results make clear modulatory role exercise relationship objective measures perception
motion estimation key building block image processing pipelines many different contexts ranging efficient coding video sequences consumer electronics domain professional medical applications many block matching approaches proposed literature motion detection compensation general including algorithms however real time medical imaging applications characterized high frame rates needs low latency accuracy robustness noise quite difficult achieve standard block matching methods introduce new hybrid image processing approach block matching takes advantage types algorithms image content noise provides high flexibility speed accuracy tradeoff presented approach successfully tested interventional ray cardiac ultrasound images sequences
effective interpersonal communication depends ability perceive interpret nonverbal emotional expressions multiple sensory modalities current theoretical models propose visual auditory emotion perception involves network brain regions including primary sensory cortices superior temporal orbitofrontal cortex however relatively little known dynamic interplay regions gives rise perception emotions recent years increasing recognition importance neural oscillations mediating neural communication within functional neural networks review studies investigating changes oscillatory activity perception visual auditory emotional expressions aim characterize functional role neural oscillations nonverbal emotion perception findings reviewed literature suggest theta band oscillations consistently differentiate emotional neutral expressions early theta synchronization appears reflect initial encoding emotionally salient sensory information later central theta synchronization reflect integration sensory information internal representations additionally gamma synchronization reflects facilitated sensory binding emotional expressions within regions potentially amygdala however evidence ambiguous comes role oscillations within alpha beta frequencies vary function modality modalities presence absence predictive information attentional task demands thus synchronization neural oscillations within specific frequency bands mediates rapid detection integration evaluation emotional expressions moreover functional coupling oscillatory activity across frequency bands supports predictive coding model emotion perception emotional facial body expressions facilitate processing emotional
background purpose data monitoring responsible interests study participants integrity credibility clinical trials independence data monitoring investigators essential achieving mission creative approaches needed address ongoing emerging challenges potentially threaten data monitoring independence effectiveness methods expert panel representatives academia industry government regulatory agencies discussed challenges proposed best practices operating principles effective functioning contemporary data monitoring results conclusions prospective data monitoring committee members need better training options include didactic instruction provide real world experience data monitoring committee members protected legal arising service avoiding confidentiality data remains high priority data monitoring access efficacy safety data throughout trial enable informed judgments risks benefits rigid procedures compromise independence data monitoring flexibility necessary best fulfill responsibilities data monitoring committee principles guide data monitoring committee process rather list rigid set requirements data monitoring develop recommendations consensus rather voting processes format meetings data monitoring committee maintain independence clearly establish leadership data monitoring committee independent statistical group statistical data analysis center sufficient depth knowledge study hand experience trials general ensure data monitoring committee access timely reliable readily insights emerging evidence clinical trial contracts engaging data monitoring committee members industry sponsored trials language customized unique responsibilities data monitoring committee members rather use language appropriate product development regulatory scientists benefit experiencing data monitoring committee service conflict regulatory responsibilities
objectives investigate association reproductive history indicators hormonal exposure including reproductive period pregnancy use hormonal contraceptives mid late life cognition postmenopausal women design analysis baseline data two randomized clinical trials womens soy health early late intervention trial estradiol setting university academic research center participants naturally menopausal women measurements participants uniformly evaluated using cognitive battery structured reproductive history questionnaire outcomes composite scores verbal episodic memory executive function global cognition reproductive variables included ages pregnancies menopause reproductive period number pregnancies use hormones contraception menopausal symptoms multivariable linear regression used evaluate associations cognitive scores dependent variable reproductive factors independent variables adjusting age race ethnicity income education results multivariable modeling age older inversely associated global cognition last pregnancy age positively associated verbal memory use hormonal contraceptives positively associated global cognition trend verbal memory trend association hormonal contraceptive use verbal memory executive function strongest years use reproductive period positively associated global cognition executive function conclusion sample healthy postmenopausal women reproductive life events related sex hormones including earlier age later age last pregnancy longer reproductive period use oral contraceptives positively related aspects cognition later life
many schemes proposed search encrypted relational databases less attention paid nosql databases paper report design implementation security scheme called searching encrypted cloud nosql databases solution one first efforts covering data confidentiality also integrity datasets residing cloud server system secure proxy carries required transformations cloud server modified construction applicable nosql data models experiments present application document store data model contributions paper include descriptive language based subset tool create security plan consisting cryptographic modules data elements mappings cryptographic modules data fields query data validation mechanism based security plan elsevier ltd rights reserved
cultivated worldwide importance associated previously found many varieties study three large cloned using modified single primer amplification technique three lengths shared conserved untranslated terminal regions contained major open reading frame encoding protein protease respectively virus like particles approximately diameter isolated infected plants northern blotting indicated virus containing genome segments named phylogenetic analysis revealed new species family forms plant another putative plant mosaic associated virus furthermore fungal observed leaf tissues stained blue results indicated likely plant rather symbiotic fungi exhaustive blast analysis revealed like viruses widely exist plants segments plant genome ever happened elsevier rights reserved
among recent high profile scientific debates proposal life exist arsenic place nucleic acids biomolecules soon initial publication scientists across diverse disciplines began question extraordinary claim using original article claims scientific support two day active learning classroom exercise developed focusing presentation evaluation discussion scientific discourse assignment first semester biochemistry course undergraduate students analyze scientific support original research articles present discuss multiple scientific civil classroom debate assignment students develop sense especially original arsenic based life claims learn clearly scientific support critical reasoning direct integration first semester biochemistry curriculum surrounding arsenic based life assignment provides robust simple stimulating framework introducing scientific discourse active learning undergraduate molecular science curriculum international union biochemistry molecular biology
critical barrier successful prevention treatment recurrent prostate cancer detection eradication metastatic therapy resistant disease despite fall diagnoses mortality reported incidence metastatic disease increased since prostate cancer arises cohesive groups muscle leaves gland via invasion dissemination current technological advances shown cohesive clusters tumor also known within circulation circulating tumor cell profiles indicative disseminated prostate cancer disseminated tumor cells found cohesive clusters phenotypic characteristic radiation drug resistant tumors recent reports cell biology informatics coupled mass spectrometry indicate integrin network provides explanation biophysical ability cohesive clusters tumor cells thorough muscle nerve maintaining adhesion dependent therapeutic resistance targeting cohesive clusters takes advantage known ability extracellular matrix ecm adhesion promote tumor cell survival represents approach potential avoid progression drug radiotherapy resistance following review examine evidence development dissemination cohesive clusters metastatic prostate cancer published elsevier
food security main concern government due malnutrition worldwide aim study assess amino acids five species consumed rural urban communities samples captured different climatic environment conditions vegetation grows raw analyzed dry basis methods amino acids cation exchange chromatography obtained data showed high protein content ranging lipids minerals fiber soluble carbohydrates including essential amino acids play important role human metabolism tryptophan limiting factor different species studied high proteins essential human life decrease protein energy malnutrition excess amino acids releasing amino group provide energy soluble carbohydrates also minerals needed prevent anemia fiber non carbohydrates essential healthy diet conclusion daily consumption good source nutrients provide optimal health population
non diseases cardiovascular disease cvd obesity cancer pulmonary disease diabetes high global health concern health costs risk factors cvd hypertension mounting example estimated direct indirect costs due billion projections six fold increases importance low cost interventions involving collaborative teams health care professionals critical junction certainly data supported research including clinical trials healthy living interventions support deploying health education nutrition smoking cessation physical activity preventing cvd risk exercise training blood pressure control shown effective integral component management however less known optimization modalities nutrition lifestyle tracking modern era technologies bring equation new research methods need consider collaborate collect data using teams researchers interacting community centers school systems traditional health care practices review discuss present known research support modern era healthy living medicine data integrated support health lifestyle community schools work place elsevier inc rights reserved
develop linear representation theory chief example associated forests graph lift chief example associated spanning forests bias lift biased graphs theory expressed largely terms edge kirchhoffs voltage law values additive group scalar field emphasize values cyclic groups finite vector spaces since crucial representing finite fields integer valued bounded breadth since crucial constructions find bounds existence solve examples results number group polynomial function group order number integral bounded breadth polynomial breadth bound conclude application complex representation many open questions elsevier inc rights reserved
engine type axial piston pump developed oil drawing properties high hydraulic pressure evaluated engine now installed underwater achieve long term monitoring ocean environments depth designated area lower operational costs functioning pump control amount oil draw operations drawing oil high pressure hydraulic pump electric motor respectively act hydraulic motor electric generator generated electric power absorbed damping resistor oil drawing properties measured using large chamber able produce almost identical environment actual operations results confirmed stable oil operations regarding oil drawing properties although measured chamber inferred system draw oil control precisely replacing two way ball valve electromagnetic valve
objective estimate incidence hepatitis virus hcv risk severe fibrosis cirrhosis hcv among persons human immunodeficiency virus hiv infection methods analysed data persons hiv enrolled cohort study italy results incidence rate person years overall drug users sex men highest risk cumulative risk progression severe fibrosis cirrhosis years conclusions new hcv infections rapidly progressive course population persons hiv hcv prioritized treatment anti hcv direct acting european society clinical microbiology infectious diseases published elsevier ltd rights reserved
objective order guide innovation looked feasibility utility performing targeted needs assessment communication skills internal medicine residents continuity clinic utilizing faculty direct observation validated instrument communication skills evaluation methods convenience sample residents university school medicine program invited participate using framework checklist medical communication tasks faculty assessed residents clinic encounter results thirty residents assessed results indicate residents likely maintain patients privacy patient appropriately check clarify information residents least likely waiting time explore psychosocial emotional factors outline agenda visit conclusion framework feasible tool evaluate communication skills residents clinic setting many residents large urban practice elicit important psychosocial information outpatient clinic visits practice implications observation evaluation residents communication skills needed emphasis building skills understand patients perspective elsevier ireland ltd rights reserved
pathogen causes green decay fruit resulting severe economic losses explore possible factors involved fungal pathogenesis phenotypic characterization yeast mitogen activated protein map kinase homolog carried map kinase coding gene designated functionally via homologous recombination fungal strain delta carrying deletion demonstrated altered gene expression profiles reduced growth elevated resistance osmotic stress failed induce green decay fruit delta resistant nacl progenitor strain indicating negative regulatory function osmotic stress adaptation fungal infection assays fruit revealed delta poorly within host tissues induced water lesions failed break host layers thus failed produce aerial introduction functional copy null mutant restored defective phenotypes transcriptome analysis revealed inactivation impacted expression genes associated cell wall degrading enzyme activities carbohydrate amino acid formation numerous metabolic processes results define pivotal roles mediated signaling pathway developmental pathological functions pathogen elsevier rights reserved
wheat one major foods worldwide population iron plays significant role growth development plant report presenting genome wide identification iron binding proteins wheat wheat genome derived putative proteome screened identification iron binding sequence motifs putative iron binding proteins able produce reliable structural models homology techniques analyzed presence iron binding structural motifs computationally identified proteins appear bind ions showed diverse coordination geometries asp amino acid residues found mostly involved iron binding classified proteins basis localization different cellular compartments identified proteins classified protein folds families functional classes ranging structure maintenance cellular components regulation gene expression post translational modification membrane proteins enzymes signaling storage proteins comprehensive report regarding structural iron binding proteome provides useful insights diversity iron binding proteins wheat plants utilized study roles plant growth development physiology elsevier inc rights reserved
paper presents results computational fluid dynamics cfd model study hydraulics groundwater flow porous pipe study conducted using three dimensional cfd model built ansys model validated replicating previous experimental results saturated subsurface flow water surface level aggregate pipe loose laid aggregate cfd model consistently flow rate given head aggregate depth average considering effect pipe due aggregate average decreased discharge coefficient pipe computed using cfd model compared experiments also found discharge quite small upstream end pipe bulk water entering pipe vicinity outlet finally computational results showed saturated flow conditions flow predominantly vertical direction within aggregate whereas mainly horizontal water surface level top aggregate level unsaturated condition losses associated two flow scenarios explored results obtained practical applications design analysis porous pipe
purpose review ensuring quality safety face restrictions changing demographics challenging france environment regulated legislation often necessary find solutions opportunities break traditional organization recent findings postoperative mortality remains high move towards ambulatory care adequately integrated stages patient management context single therapeutic plan mutually agreed upon caregivers french national health authority provides certification healthcare encourages seamless approach private practice hospital setting based teamwork interdisciplinary consultation break traditional organizational structures taking account human factors strategies possible deliver appropriate care level quality safety meets users demands summary management patient undergoing surgery seamless spectrum patients home hospital back home decision making multidisciplinary increased use ambulatory care breaks traditional organizational structures efforts reduce postoperative mortality represents opportunities improve overall system performance demographic economic constraints potential threats identified
literature pertaining rehabilitation ice players seeking return sport anterior cruciate ligament reconstruction currently limited purpose clinical commentary present criterion based progression return ice athletes first review pertinent literature provide previously published guidelines general rehabilitation present phase ice progression objective criteria initiate phase early ice phase athlete specific demands including graded exposure forward backward crossover intermediate ice phase emphasis shifts developing power introducing anticipated changes direction within controlled environment late ice phase focus progresses developing anaerobic endurance introducing changes direction still without players contact finally objective return sport criteria met team even practices games progressively return sport phase recommendations ice strength conditioning exercises complement ice progression additionally apply return progression framework case report female defensive ice player returned sport successfully criterion based return progression guide rehabilitation specialists managing athletes returning ice
objectives evaluate association hypothyroidism health status older hispanic non hispanic white men women accomplish determined treated untreated conditions examined associations elevated serum thyroid stimulating hormone tsh cognitive affective mood functions symptoms comorbidity specifically coronary heart disease chd diabetes hypertension design setting cross sectional study equal numbers hispanic men women selected randomly health care administration medicare recruited home interview followed hour interview examination senior health clinic participants volunteers mean age years participated interviews examinations measurements serum tsh determined participants responding questions thyroid replacement therapy serum free thyroxine free concentrations determined participants elevated tsh concentrations symptoms cognitive tests screen depression comorbidities chd risk factors lipid abnormalities diabetes hypertension compared participants high versus normal tsh values results subclinical hypothyroidism common women men non hispanic white women compared hispanic women differences observed participants tsh elevations normal tsh concentrations differences observed tsh concentrations conclusions subclinical hypothyroidism common condition community living older people especially women however appeared effect measures health status utilized serum tsh concentrations exceeded even effects rarely significant
recent research highlights potential benefits practice without feedback learners strategy knowledge however prior work conducted one one settings short retention intervals compared effects mathematics practice without correct answer feedback immediate week delayed performance classroom setting randomized experiment second third grade children received strategy instruction practiced solving relevant problems small groups within classroom practice children received immediate feedback problem feedback problems set feedback practice task immediate feedback led best performance however practice without feedback led higher levels week knowledge retention test thus instructional practices seem less effective first children ultimately result desirable learning
either cardiovascular peripheral vascular diseases become major cause morbidity mortality worldwide recently growth factors therapeutics form exogenous growth factors relevant genes discovered effective strategy prevention therapy vascular diseases promoting angiogenesis besides alternative stem cell based therapy also developed view mediated effect ability differentiation toward angiogenesis related cells assistance growth factors despite specific potent matter growth factors stem cells based therapy full clinical transformation limited bench review potential choices therapeutic modes based types different growth factors stem cells firstly summarized vascular diseases confronted various challenges lack non invasive delivery method challenge short half life time poor cell survival carefully analyzed therapeutic modes various strategies overcome limitations put forward perspective drug delivery design suitable delivery form undoubtedly provide valuable insight clinical application regenerative medicine
cell lymphoma follicular helper cells characterised polymorphic neoplastic cells forming small clusters around follicle high endothelial despite recent advances phenotypic characterisation genetics molecular mechanisms underlying fully understood present study performed whole exome sequencing cases taiwan confirmed frequent mutations recently reported others importantly identified mutations yet seen strongly implicated pathogenesis among pathogenic mutations identified mutations dna methylation regulators occur early hematopoietic stem cells shown previous studies genetic events enhance self renewal hematopoietic stem cells unlikely major impact cell differentiation mutations encode proteins critical cell biology likely promote cell differentiation malignant transformation consequently generating malignant phenotype findings extend molecular insights multistage development
study designed compare motion female male soccer players determine mechanical technical characteristics female players motion capture system used compare ball velocity foot velocity mean peak knee joint torques angle mean energy ratio female male soccer players elucidate mechanical technical characteristics female players ball impact values ball velocity foot velocity immediately impact mean peak knee joint torques mean energy ratio smaller female players male players authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering university
deterioration shot casting due thermo mechanical fatigue often results lowering reliability availability casting machine thus reducing productivity meanwhile increasing life cycle maintenance cost paper presents efficient bayesian meta modeling method spatiotemporal prediction data uncertainty non target applications controlling deformation optimizing machine design predicting component fatigue cracking thus improving reliability availability mechanical system spatiotemporal model established substitute complicated computer model using numerically simulated data bayesian probabilistic approach developed quantitatively evaluate validity predictive capacity meta model considering data uncertainty fit test employed perform hypothesis test difference values validation data box cox transformation method utilized convert non data purpose facilitating overall validation assessment meta models higher accuracy bayesian confidence measure presented quantify confidence predictive capacity meta models given transformed data procedure proposed implement proposed probabilistic methodology meta modeling model validation non response series impact data assumption decision threshold parameter quantitative model assessment also investigated using bayesian inference approach effectiveness proposed methodology procedure demonstrated spatiotemporal temperature prediction casting
suggested earlier subject prejudice often become perpetrators prejudice indeed collect oral histories post war migrants regularly confronted angry statements just let given lies heart phenomenon clearly prejudice exists societies seems particularly evident societies ongoing flow migrants continues change alter ethnic racial mix article reflects upon research conducted stories project frequently confronted even comments migrants interviews migrants statements made ask whether correct observations drawing literature various disciplines consider various influences attitudes towards migrants propose critical continue progress beyond conventional topics explored migration studies ask difficult questions order contribute growing global discussion ethnicity intergroup relations especially relation prejudice racism
background high mobility group box non histone protein plays important role autoimmune diseases however significance pathogenesis autoimmune thyroiditis reported purpose study explore whether participates pathogenesis autoimmune thyroiditis whether direct inhibitor attenuates severity thyroid inflammatory infiltration murine model autoimmune thyroiditis methods total male mice randomly divided control iodine supplement group four weeks age control group fed regular water whereas group supplied sodium iodine water another male mice also randomized three groups eight mice per group follows control treatment iodine supplementation mice fed sodium iodide water eight weeks enhance autoimmune thyroiditis iodine treatment mice received intraperitoneal injections four weeks severity lymphocytic infiltration thyroid gland measured histopathological studies serum levels tumor necrosis factor alpha interleukin beta antibody titers measured using enzyme linked immunosorbent assay expression measured immunohistochemical staining real time polymerase chain reaction nuclear transcription factor kappa measured western blot results mrna expression significantly higher weeks group control group serum levels antibodies tumor necrosis factor alpha beta significantly increased group dramatically attenuated injection prevalence thyroiditis infiltration lymphocytes significantly decreased group administration also significantly reduced protein expression nuclear transcription factor thyroid gland attenuated severity thyroiditis conclusion play crucial role autoimmune thyroiditis causing inflammatory infiltration thus increasing severity autoimmune thyroiditis effectively attenuated thyroiditis iodine induced mice via molecular mechanism related inhibition signaling
article investigates sampled data disturbance rejection control problem class non integral chain systems uncertainties aiming reject adverse effects caused general uncertainties via digital control strategy new generalized discrete time extended state observer first proposed estimate lumped disturbances sampling point disturbance rejection control law constructed sampled data form lead easier implementation practices carefully selecting control gains sampling period sufficiently small state growth zero order input bounded input bounded output stability hybrid closed loop system disturbance rejection ability proved even controller within two neighbor sampling points numerical simulation results demonstrate feasibility efficacy proposed method
antibody increases osteoblast activity part increasing modeling based bone formation previously quiescent surfaces studies suggested occur conversion bone cells active osteoblasts however direct data demonstrating induced conversion cells active osteoblasts lacking used vivo lineage tracing determine promotes conversion cells osteoblasts bone surfaces mice two independent inducible lineage tracing strategies used label mature osteoblasts progeny using osteocalcin promoters prolonged period majority labeled cells bone surfaces assumed thin quiescent morphology mice treated either vehicle twice course subsequent week marked cells thickness quantified proliferation apoptosis examined led significant increase average thickness labeled cells bone surfaces consistent osteoblast activation induce proliferation labeled cells regulate apoptosis labeled cells therefore direct reactivation quiescent bone cells contributes acute increase osteoblast numbers treatment mice american society bone mineral research
new look description phenomenon electromagnetic wave radiation phase transition quasi static field state near zone field running wave far zone suggested demonstrated boundary transition called causal surface sufficiently localized position causal surface depends chosen radiation frequency skin layer media strong absorption formed boundary causal surface used depth sensing media
posttraumatic stress disorder ptsd often share morbidity chronic pain conditions recent studies suggest role receptors atp signaling pain conditions however underlying mechanisms visceral following exposure ptsd like stress conditions remain methodsthe behavior hormones relevant ptsd studied responses abdominal withdrawal colorectal recorded determine receptor mediated alteration following single prolonged stress exposure immunofluorescence western blotting patch clamp used key resultsthe escape latency hormone cortisol increased days responses reduced day rats increased higher levels controls exposure day administration receptor antagonist atp abolished response based immunofluorescence western blotting analysis treated rats exhibited reduced expression dorsal root ganglia day compared controls expression enhanced day increase expression maintained day compared controls receptor agonist atp induced fast current neurons control treated rats average peak current densities treated group increased fold atp markedly blocked fast atp induced currents neurons control treated rats conclusions data indicate important role signaling visceral following ptsd like stress
complex analytic isolated considered context symbolic computation motivations paper computer calculations sequences introduced study whitney deformations complex new algorithm utilizes parametric local systems proposed compute sequences lists sequences typical cases also given
current atherosclerosis treatment strategies primarily focus limiting esters accumulation reducing endogenous synthesis cholesterol liver therapy currently available enhance removal crucial step reduce burden existing disease given central role hepatic ester hydrolase hydrolysis subsequent removal resulting free cholesterol work applied generation hepatocyte specific delivery expression vector data presented herein show increased specific uptake expression vector complexes simply hepatocytes vitro vivo furthermore upregulated expression hepatocytes significantly enhanced intracellular hydrolysis high density lipoprotein associated hdl subsequent conversion secretion bile acids increased expression liver significantly increased flux hdl fecal meanwhile induce hepatic renal toxicity also encouraging pre clinical testing results using safe highly efficient hepatocyte specific gene delivery platform enhance hepatic processes involved cholesterol elimination promising strategy atherosclerosis elsevier ltd rights reserved
background animals show seasonal changes endocrine immune system response stressors even though increased inflammation implicated pathophysiology depression whether immune disorder key mediator seasonal affective depression sad unknown hypothesized short induce inflammatory response contributes sad light treatments normalize immune function improve depressive symptoms methods twenty patients diagnosis sad score higher recruited study twenty one healthy subjects personal family history psychiatric disorder matched patients according age sex patients controls sampled winter november january inclusive subset sad patients sampled weeks light therapy blood samples assayed macrophage activity lymphocyte proliferation cytokine release results sad patients showed significantly higher macrophage activity lower lymphocyte proliferation winter compared healthy subjects concentrations macrophage produced proinflammatory cytokines interleukin beta tumour necrosis factor alpha helper produced cytokine interferon significantly increased contrast significant changes produced cytokines observed light therapy significantly improved depressive scores associated attenuation decreased lymphocyte functions increased macrophage activity level proinflammatory cytokines conclusion sad patients increased macrophage type responses winter light therapy normalized immune functions depressive symptoms results support inflammatory hypothesis sad immunomodulatory role light elsevier rights reserved
approximately sudden cardiac deaths unexplained sudden death syndrome survivors cardiac arrest cardiac abnormality comprehensive clinical evaluation idiopathic ventricular fibrillation genetic testing able play role diagnostics targeted underlying phenotype present family members following clinical evaluation alternatively post mortem genetic testing molecular autopsy diagnose underlying cause clearly pathogenic rare variant found limitations include modest yield high probability finding variant unknown significance leading low signal noise ratio next generation sequencing enables cost efficient high throughput screening larger number genes expense increased genetic noise yield genetic testing even lower absence suggestion another phenotype index case family actively time future improvements diagnostic utility include optimization use variant calling pipelines shared databases patient specific models disease accurately assign pathogenicity variants studying parents index case better assess yield sporadic recessive disease elsevier inc rights reserved
person perception research focused accuracy observers receiving target information however real life people often wish manage impression convey investigated whether people pose personality photographs sixty target participants posed photographs sought express high low poles big five traits means physical observers rated targets personality results showed targets successfully posed lesser extent non open targets convey impressions high low elsevier inc rights reserved
water reuse schemes urban water system assessed paper number hydraulic performance indicators city metabolism model used evaluate performance water reuse schemes multi objective evolutionary algorithm employed identify pareto optimal solutions following three objectives resilience reliability total cost demonstration suggested approach real world case study show importance using resilience index determining appropriate schemes results suggest case analysed rainwater harvesting scheme plays significant role improvement resilience index authors published elsevier ltd
background american thoracic society european respiratory society guidelines single breath capacity lung carbon monoxide recommend weekly biological control test simulator detect instrument error drift little published regarding results quality assurance program aim analyze long term stability portable instrument methods used new pro system checked accuracy using simulator reference gases concentration carbon monoxide concentration first use large clinical laboratory detect instrument drift healthy woman msc age old baseline tested every week period time results done using instrument patients failures daily volume flow calibration performed automatically instrument differences simulator measured min min concentration concentration respectively results biological control tests mean min coefficient variation repeatability min measurements outside min mean alveolar volume coefficient variation inspired volume coefficient variation conclusions measurements stable period without need manual instrument biological control good simulator evaluate kind device long term laboratory quality control program
hiv latency characterized reversible silencing viral transcription driven long terminal repeat promoter hiv cellular viral factors regulating activity contribute hiv latency certain cellular factors modulate viral transcription silencing associated factor host protein regulates multiple cellular signaling pathways hiv production recently reported nuclear promoted nuclear export hiv mrna leading increased production demonstrate new functions regulating hiv persistence found contributes maintenance hiv latency inhibiting driven hiv gene transcription nuclear factor kappa dependent manner interestingly knockdown significantly enhanced viral reactivation hiv infected cells primary central memory cells furthermore knockdown resting cells hiv infected individuals treated antiretroviral therapy significantly increased viral reactivation upon cell activation suggesting important role modulating hiv latency vivo findings provide new insights better understanding hiv latency suggest inhibition activity activate hiv infected cells potential therapeutic strategy importance hiv latency characterized mainly reversible silencing promoter driven transcription integrated cellular viral proteins regulating activity contribute modulation hiv latency study found host protein inhibited hiv driven transcription hiv genes contributed maintenance hiv latency findings provide new insights effects host modulation hiv latency lead potential therapeutic strategy hiv persistence targeting protein
crop water status important parameter plant growth yield performance thus early detection water stress essential efficient crop management dynamic response plants changes environment called speaking plant platforms remote sensing measurements offer possibility monitor real time crop health status without affecting crop environmental conditions therefore aim work use crop reflectance temperature measurements acquired remotely crop water status assessment two different irrigation treatments imposed tomato plants grown namely tomato plants irrigation certain period plants plants grown controlled growth chamber measurements carried august september crop reflectance measurements carried two types sensors camera measuring radiation reflected three spectral bands centred regions measuring leaf reflected radiation based measurements several crop indices calculated results showed crop reflectance increased due water deficit detected reflectance increase significant following irrigation results first derivative analysis reflectance data showed spectral regions centred used crop status monitoring addition results present study point reflectance index modified red simple ratio index modified ratio normalized difference vegetation index used indicator plant water stress since values correlated substrate water content crop water stress index last extensively used crop water status assessment open field thus concluded reflectance crop temperature measurements combined provide alarm signals crop water status reaches critical levels optimal plant growth
examine extent utility scores capture effect mental physical health status life satisfaction older adults retrospective cohort study patients aged years general practices ireland including medical records pharmacy claims self completion questionnaire path analysis used evaluate direct indirect effects chronic disease burden based medications data activity limitation basic instrumental activities daily living anxiety symptoms depressive symptoms hospital anxiety depression scale life satisfaction index via utility score based responses scale utility scores calculated using time trade utility weights covariates included age socioeconomic status final path model fitted data fit chi direct effects chronic disease burden disability statistically significant excluded final model indicating score mediated total effect direct indirect effects anxiety depression statistically significant size indirect effect small total effect anxiety total effect depression adequately capture effects anxiety depression among older adults suggesting lead inaccurate assessments effectiveness interventions cohort
frequent symptom patients irritable bowel syndrome ibs associated poor quality life however studies evaluated impact daily life perceived distress cause using multi methods approach study describes impact manifestations fatigue patients ibs investigates relationship fatigue severity illness related health promoting factors methodsa total patients ibs completed self reported questionnaires assessing fatigue gastrointestinal symptoms psychological distress sense coherence fatigue assessed fatigue impact scale also includes structured open ended questions analyzed qualitative analysis patients classified severe moderate mild fatigue based frequency distress impact daily life key resultsthe open ended questions revealed multidimensional impact life fatigue mainly ability perform physical activities work domestic work ability interact socially decreased evident along strategies limit bodily consequences severe fatigue accompanied severe ibs symptoms anxiety depression lower sense coherence conclusions symptom occurs proportion patients ibs affects life multidimensional way poor bodily prominent feature fatigue along sense coherence depression anxiety needs assessed confirmed targeted interventions
extracting powerful image features plays important role computer vision systems many methods previously proposed extract image features various computer vision applications scale invariant feature transform speed robust feature local binary patterns histogram oriented gradients weighted recently convolutional neural network cnn method image feature extraction classification computer vision used various applications research propose new gender recognition method recognizing males females observation scenes surveillance systems based feature extraction visible light thermal camera videos cnn experimental results confirm superiority proposed method state art recognition methods gender recognition problem using human body images
present frame invariant method detecting coherent structures lagrangian flow trajectories sparse number case many fluid mechanics applications practical interest method based principles used graph spectral graph drawing algorithms examines measure kinematic pairs fluid trajectories measured either experimentally using particle tracking velocimetry numerically fluid particles velocity field coherence assigned groups particles whose kinematics remain similar throughout time interval trajectory data available regardless physical proximity one another use several analytical experimental validation cases algorithm shown robustly detect coherent structures using significantly less flow data required existing spectral graph theory methods
construct quasi topological gravity five dimensions theory lagrangian containing terms whose field equations second order hyperbolic planar symmetric theories recently received attention since formulated asymptotically ads provide gravity broad class simplicity focus five dimensions show theory theorem case gravity therefore generic values wave propagating mode prove symmetric solution determined algebraic polynomial equation resembles polynomial gravity black hole solutions compute temperature mass entropy show first law black holes thermodynamics fulfilled besides fourth order general show field equations linearized around ads second order therefore theory propagate around background besides class theories originally introduced general geometric structure remains open problem
background immunosuppressive therapy places pediatric patients risk developing life threatening infections diagnosis treatment challenging owing nonspecific signs symptoms aim study present departments experience surgical management acute children methods records children hematologic disease underwent endoscopic sinus surgery acute january reviewed data retrospectively collected demographics clinical imaging characteristics microbiology pathology treatment outcome results thirty four children underwent acute patients fungal infection nineteen patients died end follow deaths infection related facial swelling symptom correlated death infection relapse underlying disease bone marrow transplantation long duration neutropenia correlated infection related mortality fungal infection specifically aspergillus correlated death infection conclusions safe efficient procedure diagnosing treating pediatric patients acute early detection aggressive medical surgical treatment control underlying risk factors crucial improve outcome
validate model arm cortex microcontroller core testing models behaviour randomly chosen instructions real chips several manufacturers model intended application involve precise timing information instruction execution implementations checking behaviour single instructions give sufficient confidence model thus test model using sequences randomly chosen instructions main challenge meet constraints initial intermediate execution states ensure memory range respect restrictions instructions careful transformation constraints shelf solver used find suitable states executing test sequences also use additional constraints test hypotheses timing anomalies encountered elsevier rights reserved
evolution low energy nuclear physics publications last years analyzed using nuclear physics databases extensive study nuclear science references experimental nuclear reaction data evaluated nuclear structure data file contents provides unique picture non nuclear physics references significant fractional contributions non reports private communications conference databases reflect extensive experimental campaigns insufficient number research journals trend reversed recent years number measurements much lower number journals higher addition nuclear physics results mainly published limited number journals physical review nuclear physics present work historic publication trends extracted analyzed using nuclear data mining techniques results study implications discussed conclusions presented
wearable healthcare devices monitoring treating protecting applications provide reliable interactive service people herein functional smart face mask based nonwoven developed virtue charges maintained steadily nonwoven smart face mask possesses functions removing particulate matter generating electricity moreover unique applications dynamically monitoring particulate matter removal ability humans respiratory rates demonstrated besides offering unique air filter study promote progress self powered wearable electronics
advanced jet engines operate application vacuum optimal use advanced military applications drives much basic innovative research development especially new needs arise rapidly changing domains stealth agile aircraft stealth jet unmanned air vehicles uav reasons periodically update journal new trends affect sometimes control research development future jet engines one relevant example recently stealth improved version smaller captured iran important new stealth uav dominate future uses fuel efficient jet engines especially operating environments designed funded since based classified parent israeli protect hundreds design testing trade taken united states government via classified contracts contractors general dynamics general electric revealed december week court federal circuit case new design explains recent air force shift away permissive environments non global general operate toward new highly strongly
background aims evaluate clinical course hip arthritis risk factors hip joint replacement patients ankylosing spondylitis methods retrospective analysis evaluated patients single tertiary hospital baseline recent visit outpatient clinic patients hip arthritis radiographic hip arthritis evaluated using bath ankylosing spondylitis radiology hip index also average hip joint space width distance three distinct sites femoral head recorded results among patients patients hip arthritis erythrocyte sedimentation rate associated hip involvement odds ratio confidence interval long disease duration advanced axial disease associated severe hip arthritis baseline distance significantly change patients hip involvement follow period months five patients hip joint replacement surgery follow period body mass index bmi baseline associated joint replacement surgery hazard ratio respectively conclusions patients hip arthritis showed significant radiographic progression follow period high bmi advanced hip arthritis baseline associated hip joint replacement surgery patients
component canonical kappa pathway recently reported mutated limited number patients associated mutations non canonical pathway previously shown impair cell cytotoxic activity although biological function non human cells reported role mutations human cell biology disease investigated yet decided therefore evaluate role mutations human cell maturation functions show mutated cells present impaired maturation defective cytotoxicity reduced ifn gamma production upon vitro stimulation furthermore human activated mutated cells fail regulate expression activating marker show reduced proliferative capacity data suggest plays essential novel role human cell maturation effector functions elsevier inc rights reserved
lambda interferon ifn lambda potent antiviral effects multiple enteric viral pathogens including preventing infection intestine includes diverse array cell types however cell upon ifn lambda acts exert antiviral effects unclear sought identify ifn lambda responsive cells generation mice lineage specific deletion receptor ifn lambda found expression intestinal epithelial cells small intestine colon required enteric ifn lambda antiviral activity iec expression also determines efficacy ifn lambda resolving persistent murine infection regulates fecal shedding viral titers tissue thus expression necessary response endogenous exogenous ifn lambda demonstrate iec expression required innate immune effects ifn lambda extending findings deficient mice finally assessed whether findings multiple viral pathogens infecting mice specifically lacking iec expression mice null animals exhibiting increased intestinal tissue titers enhanced fecal shedding thus critical cell type responding ifn lambda control multiple enteric viruses first genetic evidence supports essential role ifn lambda mediated control enteric viral infection findings provide insight mechanism ifn lambda mediated antiviral activity importance human leading cause epidemic worldwide type iii ifn lambda control enteric viral infections gut shown cure mouse small animal model using genetic approach conditional knockout mice identified dominant ifn lambda responsive cells control enteric virus infection vivo upon murine infection depletion largely phenotype seen mice higher intestinal tissue viral titers increased viral shedding stool moreover ifn lambda mediated immunity murine requires capacity respond ifn lambda findings clarify mechanism action cytokine emphasize therapeutic potential ifn lambda treating mucosal viral infections
explored computer vision techniques used detect engagement students completed structured writing activity draft feedback review similar activities encountered educational settings students provided engagement annotations concurrently writing activity retrospectively videos faces activity used computer vision techniques extract three sets features videos heart rate animation units microsoft face tracker local binary patterns three orthogonal planes top features used supervised learning detection concurrent retrospective self reported engagement area roc curve auc used evaluate classifier accuracy using leave several students cross validation achieved auc concurrent annotations auc retrospective annotations face tracker features produced best results among individual channels overall best results found using fusion channels
autosomal dominant muscular retrospectively studied three families two indian one affected members male female mean age onset weakness years patients classified according muscle groups affected face pelvic loss independent fsh four fsh fsh one progression weakness classified eight cases one static three eleven patients findings suggestive one features neurogenic involvement molecular diagnosis done southern blotting using probe digestion genomic dna twelve patients three unaffected relatives fragment smaller seen unaffected subjects size fragment varied affected subjects constant affected members family molecular diagnosis southern blotting helped provide genetic counseling families
information technology important wireless sensor network security copyright protection paper uses received signal strength indication hidden information carrier designs information algorithm affect original data bring additional communication cost novel information method suitable resource constrained wireless sensor networks simulation results show high hidden information transmission accuracy without bringing additional communication energy consumption provides new way information technology wireless sensor networks
modern commonly utilize technique called domain domain generation algorithm generate large number pseudo random domain names dynamically operators control becoming one serious threats internet security global scale prevent destructive action one pressing issues today paper focus detecting domain flux within monitored network based domain name system traffic features method captures traffic gateway monitored network extracts key features identify based examining analyzing large number legitimate domains generated discovered bias rules constructing domain names therefore introduce methodology analyzes traffic extract length expected value distinguish domain name generated humans order evaluate effectiveness proposed approach various machine learning algorithms applied train predictive models detection system proposed scheme implemented tested real local area network experimental results show proposed method achieves highest efficiency decision tree algorithms average overall accuracy false positive rate copyright john wiley sons ltd
infrared detectors core infrared imaging systems readout integrated circuits key components detectors order grasp performance circuits quickly accurately method circuit modeling using language proposed present behavioral simulation model first typical capacitor trans impedance amplifier unit showed two essential parts operational amplifier switch modeled behavioral level amp model concludes non ideal factors finite gain bandwidth product input output offset output resistance non deal factors affect switches considered switch behavioral model rise fall time resistance last time domain modeling method noise presented compared classical frequency domain method difference analysis results shows situation noise interested bandwidth difference two methods leads less sample rate noise larger times
sub multimodal analog front end energy cmos soc presented signal chain consumes five times lower power state art demonstrated snr achieved using circuit system techniques enable sub analog duty cycling input signal aware fly real time data path adaptation algorithms implemented external microcontroller synchronized power chip along sar adc lower system energy programmable asynchronous capacitive amplifier noise efficiency factor analog feature demonstrates energy efficient ecg capture wearable platform using soc simultaneously captures ecg plus heart rate using low energy every smartphone greater five days battery
combined supplementation medium chain triglycerides leucine rich amino acids vitamin increase muscle strength function elderly individuals however effects cognition unknown enrolled elderly nursing home residents mean age randomized controlled parallel group trial participants randomly allocated groups first group received leucine enriched supplement second group received supplement long chain triglycerides third group receive supplements control cognition assessed baseline intervention difference changes among groups assessed adjusting age baseline value covariates mini mental state examination mmse score group increased points geriatric rating scale mental status scale score group increased points whereas control groups decreased points points respectively combined supplementation leucine rich amino acids improve cognitive function elderly individuals
high frequency models electrical motors power converters greatly important electromagnetic compatibility characterization electrical drives electromagnetic interference filter design paper accurate effective method characterization tuning models khz mhz induction motors proposed based experimental measurements motor impedance impedance measurements taken three different configurations six winding terminals grounded three input terminals grounded common mode one input terminal two differential mode motor model structure chosen modeled using state space representation parameters tuned using genetic algorithm match real impedance corresponding configuration comparison experimental impedance measurements model impedance estimate shown tested configurations order validate model within frequency range interest
aromatic potent bacterial potential human formed heat processed proteins test strain useful test system screen food products compounds require activation forms test rat liver preparation normally used order better understand mechanisms activation respect human metabolism new bacterial strains containing human cytochrome metabolic enzymes recently developed investigated capacity one strains res screening tool food products expresses human human nadph cytochrome reductase bacterial acetyl coa strain sensitive system effects aromatic amino amino amino less sensitive amino methyl however considerably higher test system meat extracts total content ranging less efficiently detected strain rat liver activation less sensitive fewer induced dose range unknown compounds present meat extracts appear inhibit activity enzyme strain therefore demonstrated although useful tool mechanistic studies chemical carcinogenesis screening complex food matrices bacterial strain conducted caution elsevier science rights reserved
interesting emerging topic detection aims simultaneously extracting common salient objects group images one hand traditional detection approaches rely heavily human knowledge designing hand metrics possibly reflect properties salient regions strategies however always suffer poor generalization capability flexibly adapt various scenarios real applications hand current methods pursue detection unsupervised however tends performance real complex scenarios lack robust learning mechanism make full use weak labels image alleviate two problems paper proposes new framework detection integrates multiple instance learning self learning unified learning framework specifically first problem formulate detection problem paradigm learn discriminative classifiers detect object instance level formulated component facilitates method capable automatically producing proper metrics measure intra image contrast inter image consistency detecting purely self learning way second problem embedded paradigm able alleviate data ambiguity weak supervision detection guide robust learning manner complex scenarios experiments benchmark datasets together multiple extended computer vision applications demonstrate superiority proposed framework beyond state arts
order improve prediction ability welding quality high power disk laser welding new approach proposed applied classification dynamic features metal vapor six features extracted color image processing method three features including area number horizontal coordinate selected based classification accuracy rates pearson product moment correlation coefficients support vector machine model adopted classify welding quality status two categories good poor results demonstrated support vector machine model established according selected features satisfactory prediction generalization ability classification accuracy rate higher model applied prediction welding quality high power disk laser welding
paper studied anti attack performance testing methods large network anti attack performance testing process large networks different traditional testing process mainly features attacks lacking precise characteristic information determining attack act point point structure limit characteristics connections traditional detection method focuses fixed feature information directly linked take anti attack performance testing lost contact feature cause detection order avoid shortcomings paper proposed anti attack performance testing method large networks based fuzzy means clustering algorithm collected relevant data extract analysis sample characteristics use fuzzy means clustering method classification data calculations gain abnormal behavior pattern data complete anti attack performance testing large network experimental results showed using proposed algorithm anti attack performance testing large network greatly improve accuracy detection effectively maintain large network security provide users good network environment
changes expression envelope proteins thought affect development course atopic dermatitis aim study examine expression level proteins order identify new molecular markers phenotype expression levels proteins evaluated skin patients biopsies healthy subjects biopsies levels mrnas proteins reduced skin levels transcripts proteins significantly increased skin mrna level non skin correlated severity protein level non skin correlated inversely pruritus protein level skin correlated inversely severity results point important factor
bone located major tendon knee joint many although numerous aspects knee morphology ancient conserved among evolutionary occurrence highly variable among extant crown groups found birds mammals almost placental mammals absent mammals many integrate data literature first hand studies fossil recent skeletal remains reconstruct evolution mammalian infer bony likely evolved four six times crown group one stem genera outside mammals three times mammals furthermore lost several times mammals including absent acquisition least inferences evolution mammals informed existence several human genetic conditions either absent severely reduced clearly development close genomic control although responsiveness mechanical environment also important perhaps variable among taxa bony present plays important role function especially gravity providing enhanced system knee joint yet evolutionary origins persistence modifications diverse groups widely varying habits habitats running aquatic small large body sizes remain complex conclusive synthesis form function development genetics across mammalian evolution meta analysis takes initial step toward synthesis available data elucidating areas promising future inquiry
sleep known important component recovery training yet little known quality quantity sleep achieved elite athletes aim present study quantify sleep elite athletes using actigraphy individual sleep cohort athletes various sports analysed compared non athletic controls significant differences athletes controls measures apart time suggesting poorer characteristics sleep athlete group significant effect gender time mean difference minutes higher males likely range minutes sleep efficiency mean difference lower males likely range athletes showed poorer markers sleep quality age sex matched non athletic control group sleep efficiency respectively fragmentation index respectively remained within range healthy sleep descriptive study provides novel data purpose sleep elite athletes
estimate statistical interactions alcohol policy strength person related risk factors sensation seeking antisocial personality disorder attention deficit hyperactivity disorder related heavy alcohol use sectional survey swiss men living within across switzerland total swiss men mean age years participating cohort study substance use risk factors measures alcohol use disorder defined dsm risky single drinking independent variables sensation seeking antisocial personality disorder aspd attention deficit hyperactivity disorder adhd index alcohol policy strength policy strength protective odds ratio sensation seeking aspd risk factors adhd risk factor significant interactions alcohol policy strength sensation seeking identified alcohol policy strength aspd interactions indicated protective effects alcohol policy strength lost men high levels sensation seeking aspd interactions detected alcohol policy strength adhd alcohol legislation protects heavy alcohol use young swiss men protective effect lost individuals high levels sensation seeking antisocial personality disorder
order disorder lattice dynamics type studied experiment modeling activation high speed ball milling allowed synthesize pure comparatively low temperature order characterized ray diffraction raman spectroscopy density functional theory calculations based fully ordered allow assignment experimentally observed raman infrared modes evaluation earlier findings standard entropy mol bulk modulus predicted fully ordered good agreement experimental findings based quasi calorimetry samples different ordering states earlier high pressure studies respectively linear relation big raman blue shift disorder observed used rapidly quantify ordering state elsevier rights reserved
study explores use technologies improve interaction lines links form parallel circuit purpose connection reinforcement transmission paths facilitate integration new wind generation bank electrical network elsevier ltd open access article license http creativecommonsorg licenses
four diets arranged using factorial design two levels high low level acid fibre combined two levels starch replacing fibre high starch low low starch high level starch two trials conducted measure digestive efficiency rate passage respectively third trial performed network six french experimental breeding units measure growth digestive health rabbits per diet foods offered weaning significant interactions detected effect level effect starch replacement rabbit digestion performance digestive health proportional increase overall food organic matter energy observed decrease level replaced starch observed significant improvement energy units whole tract mean retention time particles significantly longer lower level diets tended increase substituted starch diets weaning food intake mainly affected level day respectively diets lesser extent replacement starch day respectively diets weight gain slightly higher high starch low diets day without effect level weaning morbidity mortality rates acute diarrhoea significantly reduced high fibre diets units respectively replacement starch significant effect
study aims explore clinical characteristics risk factors rheumatoid arthritis associated interstitial lung disease ild retrospective study patients patients underwent chest high resolution computed tomography scanning two hundred thirty seven five hundred fifty patients diagnose ild ild occurred onset ild occurred within years onset ild occurred years onset common chest characteristics ild included patterns thickening ground glass attenuation followed thickening nodules proportion pattern ild often associated lung lesions including disease pulmonary hypertension comparisons ild without ild showed male smoking age disease duration number swelling joints globulin levels erythrocyte sedimentation rate reactive protein levels lactate dehydrogenase positive rate rheumatoid factor absolute value forced vital capacity forced volume carbon monoxide diffusion rate statistically different logistic regression analysis showed age smoking elevated lactate dehydrogenase positive closely correlated ild ild occurs often within years onset lung lesions elevated lactate dehydrogenase positive smoking advanced age closely correlated ild
given time critical contextual variable organizations effectiveness indicators rarely exclude argue temporal individual differences implicit leadership theories implicit theories implicit theories time based individual differences commonly subtle effects manifest explicitly behaviors consequences real implications leaders organizations therefore conceptual paper draw attention time extent individuals passage time time perspective relative importance past present future events ongoing thought processes decision making preference style manner individuals distribute effort time working toward neglected research components leaders time related characteristics leadership research consider content structure temporal also draw attention potential inconsistency leaders temporal actual behaviors temporal leaders actual behaviors offer value specifying conditions temporal inconsistency less detrimental leader follower coordination elsevier inc rights reserved
objectives goal evaluate effect rapamycin mtor inhibitor type human endometrial cancer tumor explants methods short term tissue culture fresh endometrial cancer tumor explants performed cell proliferation assessed assay treatment rapamycin akt status documented western blotting effect rapamycin phosphorylated also assessed western blotting real time pcr used quantify mrna expression telomere length determined terminal restriction fragment southern blotting results thirteen fresh endometrial cancer tumor explants nine type four type placed short term culture treated rapamycin nine endometrial cancer tumors responded rapamycin median sensitivity rapamycin independent akt status tumors reduction phosphorylated reduction phosphorylated rapamycin decreased mrna expression endometrial cancer tumors telomere length correspond responsiveness drug conclusions rapamycin demonstrated activity fresh endometrial tumor explants independent akt status tumors demonstrated reduction phosphorylated without significant change cellular proliferation suggesting additional pathways modulate cellular proliferation thus mtor inhibitors useful targeted therapy type type endometrial cancers search remains predictive biomarker sensitivity therapy elsevier inc rights reserved
limited consideration empirical studies treatment resistant bipolar disorder exploratory study designed identify factors contributing patients bipolar disorder patients categorized low medium high levels treatment resistance based total number psychiatric medications received second analysis number mood medications received study identified number factors associated female older older age illness onset higher incidences family depression less likelihood paid employment higher number lifetime stressors medical conditions comorbid anxiety disorders different personality temperament profile regular use factors associated defined number mood potential explanations findings explored
great success second generation wireless telephone technology third generation mobile technology fast development fourth generation mobile technology phase fifth generation mobile networks fifth generation wireless systems coming article indicate open research issues security trust context networking software defined networking propose framework security trust focusing solving network security issues proposed framework applies adaptive trust evaluation management technologies sustainable trusted computing technologies ensure computing platform trust achieve software defined network security adopts cloud computing deploy various trustworthy security services networks analyze framework support satisfy security requirements specified standardization also suggest future research work according proposed framework discuss advantages framework terms practical deployment copyright john wiley sons ltd
propose new method client side data relational databases central server distant clients data loaded client cache based queries executed central database server queries special form universal relational query majority search queries database expressed form besides form allows analyze query correctness checking join property subsequent query executed clients local cache determine query result entirely contained cache compare truth spaces logical restrictions new users query results queries execution cache method used define lacking data cache execute query server data problem data cache discussed paper however solved queries server serving triggers background mode
background estimated million worldwide million recreational australia recreational activity sport grown dramatically since scientific research poorly comparison mainstream sports purpose identify incidence severity location type mechanism acute injuries recreational competitive month period study design descriptive epidemiology study methods online survey using open source survey application utilized survey consisted primary sections section included demographic information participation levels age height weight hours competitive level section incorporated injury type mechanism severity injury management results total participants males competitive included data analysis total acute injuries classified major providing incidence proportion acute injuries per year incidence rate calculated major injuries per hours shoulder ankle head face regions highest frequencies acute injury representing respectively injuries predominantly muscular joint skin origin representing respectively skin injuries primarily result direct trauma joint muscular injuries mainly result performed repetitive actions key risk factors increased incidence sustaining acute injury included competitive status hours hours week ability perform aerial incidence proportion completing aerial calculated major injuries per year highest incidence proportion irrespective competitive status conclusion largest specific survey included recreational competitive conducted australia date shoulder ankle head face identified key regions acute injuries occur research aid reducing occurrence injury musculoskeletal screening key injury prone regions use sport specific strength training conditioning
labor productivity fundamental building block planning controlling construction therefore predicting labor productivity levels given condition important construction management however predicting labor productivity extremely difficult due large number factors affect productivity ways another obstacle predicting labor productivity qualitative nature productivity factors address issues soft computing technique called fuzzy cognitive maps proposed tool model complex inter relationships productivity factors based expert knowledge assessing impact productivity factors labor productivity paper methodology creating using purpose introduced exercise presented demonstration purposes additionally issues identified exercise described way practically used field predicting labor productivity also discussed paper
use thermodynamics formalism irreversible processes complex systems theory systems biology derived relationship production entropy per unit time fractal dimension tumor growth rate human tumors cells thermodynamics framework developed demonstrates dissipation function potential also lyapunov function dynamical behavior tumor growth indicate directional character stability robustness phenomenon entropy production rate used quantitative index metastatic potential tumors current theoretical framework provide better understanding cancer contribute improvements cancer treatment elsevier rights reserved
study assessed extent high fat diet induced beta amyloid accumulation cognitive decline app mice reversible control fat intake ten months fat led significant deficits trial maze task building assay decreased voluntary locomotor activity induced inflammatory response indicated increased expression several inflammatory markers low fat diet led pronounced weight loss correction glucose intolerance decreases inflammatory response improved performance behavioral tasks wild type app transgenic mice insoluble beta amyloid levels extent tau phosphorylation also lower following dietary reversal app mice compared high fat fed animals indicating inflammatory response contributed key pathogenic pathways alzheimers disease model data suggest weight loss vital strategy cognitive protection also highlight potential mechanisms intervention sustained weight loss possible elsevier inc rights reserved
nationwide statistical analysis disease classical myeloproliferative neoplasm mpn korea reported yet end analyzed incidence rates survival rates treatment pattern polycythemia vera primary myelofibrosis essential thrombocythemia using korea national cancer incidence database health insurance review assessment service database total new cases mpn reported common followed crude incidence rates increased period reaching per respectively five year relative survival rate mpn patients lowest relative survival rate prevalence disease estimated data also increased study period notably found prevalent prescription rate hydroxyurea patients remained constant period prescription rate hydroxyurea higher patients age years first korean nationwide statistics mpn using central registry data set data utilized compare korean mpn status international data guidelines
exposure children domestic violence abuse form child maltreatment short long term behavioural mental health impact health care professionals generally uncertain respond domestic violence particularly unclear best practice regards childrens exposure role response systematic review report educational structural whole system interventions aim improve professionals understanding response survivors children searched databases contacted topic experts studies reporting quantitative outcomes type intervention aiming improve professional responses disclosure child involvement included interventions physicians nurses teachers twenty one inclusion criteria three randomised controlled trials rcts pre post intervention surveys training three system level interventions training interventions generally positive effects participants knowledge attitudes towards clinical competence results rcts consistent surveys results system level interventions aimed change organisational practice inter organisational collaboration demonstrates benefit coordinating system change child welfare agencies primary health care organisations implications policy research discussed authors child abuse review published john wiley sons ltd
tested method inoculation plants binary vectors harboring sequences sense antisense orientations constructed agrobacterium transfected binary vectors leaves northern blotting reverse transcription polymerase chain reaction analysis showed local infection established within days systemic infection within days showed difference study showed plants easy rapid cost effective method inoculation elsevier rights reserved
study tested effect political orientation importance placed agency competence morality qualities required french republic furthermore assessed participants judgments five main candidates french dimensions results showed compared left wing right wing placed greater importance agency less importance morality qualities required right wing differentiated candidates respect agency competence whereas reverse pattern observed left wing differentiated candidates respect morality much finally participants ratings candidates showed effect left wing rated left wing candidates competent moral true right wing candidates right wing ratings candidates qualities less dependent political orientation data provide support people perceived qualities necessary france
background purpose hospital acquired pressure injuries continue persistent problem acute care arena purpose retrospective quality improvement study examine introduction nurse practitioners nps wound care without interventions impacted rates community hospital methods retrospective comparison design used months data reported monthly national database nursing quality indicators survey abstracted hospital records data included assessment patients divided two groups comparison months months conclusions strong inverse correlation presence nps number patients indicating rates significantly lower nps took role odds occurring following introduction odds previous years implications practice study findings suggest nps assuming leadership role instrumental decreasing rates
background idiopathic pulmonary fibrosis ipf chronic progressive interstitial lung disease severe pulmonary fibrosis main cause ipf associated death acute exacerbation ipf ipf study aims develop rat model ipf two bleomycin methods ninety male sprague dawley rats randomized three groups ipf model group group ipf model group group normal control group rats group underwent second perfusion day first perfusion rats two groups received saline second perfusion six rats group sacrificed day day day first perfusion respectively additional rats group observed survival results rats group significantly worse pulmonary alveolar inflammation fibrosis rats group rats group also developed large amounts membrane showed high levels albumin various inflammatory factors bronchoalveolar lavage fluid markedly increased lung water content furthermore rat survival reduced group pathophysiological characteristics rats group resemble patients ipf conclusions second perfusion appears induce acute exacerbation pulmonary fibrosis used model ipf rats
computer programming courses course many universities learning course helpful students ability analytical thinking dealing issues promote formation logical thinking rigorous scientific attitude promote innovative development disciplines effective use information technology long time computer programming courses generally considered difficult courses understand study present colleges universities exploring task driven method teaching computer science application medical universities task combined teaching learning research program design course greatly increase students interest also contribute innovation course reforms study courses program design medical professional conduct industry research members research understanding industry process think computer programming ideas help students use learning resources actively carry study effectively
used skin care product immunity enhancement agent short communication studies solution high salinity high temperature experiments show maintains high viscosity high salinity loss viscosity insignificant high temperature degrees impressive stability high temperature high salinity renders potential enhance oil recovery oil gas industry field pilot carried since field results indicate injection solution oil leads improved oil production
objectives adherence allergic rhinitis clinical practice guideline considered potential focus national performance metrics help inform discussion assessed patient clinician reported medication administration among nationally representative populations patients allergic rhinitis study design cross sectional analyses setting subjects home health assessments ambulatory visits methods participants national health nutrition examination survey national ambulatory medical care survey national hospital ambulatory medical care survey assessed primary outcomes percentage patients reporting receipt nasal steroids among allergy related symptoms percentage clinician administered medications diagnosing allergic rhinitis secondary outcomes included assessments worse quality life confirmatory allergy testing receptor antagonist use results within national health nutrition examination survey estimated million patients diagnosed fever million diagnosed allergies patients symptoms allergic rhinitis reported nasal steroids prescribed cases receptor antagonists given without asthma use allergy medications within national ambulatory medical care survey national hospital ambulatory medical care survey observations representing million visits allergic rhinitis demonstrated nasal steroids administered cases given respectively conclusions despite high prevalence allergic rhinitis per patient report clinician entry substantial number affected patients receive nasal steroids
clinical preclinical studies cardiovascular calcification often require interpretation images histopathology computed tomography ultrasound positron emission tomography avoid potential pitfalls biological inferences investigators know happens data image processing algorithms limitations cross sectional images studying smoothing algorithms mask partial volume artifacts positron emission tomography
work consider learning problems clusters nodes interested estimating parameter vector cooperation among clusters beneficial optimal models adjacent clusters good number similar entries propose fully distributed algorithm solving problem approach relies minimizing global mean square error criterion regularized terms promote cooperation among neighboring clusters general diffusion forward backward splitting strategy introduced specialized case sparsity promoting closed form expression proximal operator weighted sum norms derived achieve higher efficiency also provide conditions step sizes ensure convergence algorithm mean mean square error sense simulations conducted illustrate effectiveness strategy
popular view plant mitochondrial genome evolves slowly sequence recently challenged high substitution rates mtdna documented mainly several genera high substitution rate acceleration accompanied great length variation rarely reported plant mitochondrial genes studied evolution mitochondrial gene encodes ribosomal small subunit protein found dramatically high variation length sequence exon region sequence comparison cdna genomic dna showed rna editing sites gene southern blotting analyses total dna mtdna together real time pcr analysis showed exists single mitochondrial locus likely gene experienced integration cdna mitochondrial genome followed evolutionary acceleration due intron loss addition phylogenetic analysis supports relationship particular strongly supported shared loss two results also indicate mitochondrial gene tree affected topology analyzed together genomic sequences elsevier inc rights reserved
based aerodynamic interaction vortex induced vibration torsional flutter another explanation drastic change mode symmetrical mode torsional mode introduced fundamental characteristics coupled flutter thin plate plate like structure flutter modes flutter branches explained use step step flutter analysis flutter properties obtained multi modes flutter analysis compared ones flutter analysis multi modes flutter analysis recommended use accurate verification flutter property lessons aerodynamic behavior full scale elastic model bridge reduction key equivalent aerodynamic derivatives suitable span wise arrangement different girder shapes significantly effective stabilize flutter instability long suspension bridge furthermore significantly similar formula formula derived simple assumptions application coupled flutter generation mechanism propulsion force use coupled flutter motion introduced finally confirmed mode produce propulsion force test ship navigation plate controlled particular flutter mode shown elsevier ltd rights reserved
paper presents proposed design leg rehabilitation system system implemented reconfigurable prototype order provide additional two rotational degrees freedom dof serving rehabilitation purposes lagrangian dynamic formulation used derive system dynamics joints based friction model considered leg rehabilitation system system equations motion linearized since model dealt state space representation control approach considered derived stabilization system simulation results validating model control approach presented discussed
building simulated work applied cognitive psychology present research introduces new paradigm scientific study memory childhood sexual abuse information session participants mentally took part abuse victim read account sexual assault year old reading narrative participants randomly assigned one four experimental conditions story truth group left abuse details story group abuse details indicate abuse occurred commission group recall story session group one week later participants returned session asked recall narrative results indicated relative recall recall session adversely affected memory performance session however recall resulted better memory moreover gender ptsd symptoms depression adult attachment sexual abuse history significantly predicted memory childhood sexual abuse scenario implications theory application discussed
prenatal development known extremely sensitive maternal environmental challenges study hypothesize body growth lactation gestation cattle reduce nutrient availability pregnant uterus consequences placental development fetal membranes growing fully grown blue breed compared determine effect body growth placental development furthermore fetal membranes compared study impact dam lactation compared dam body growth birth weight body measurements dam recorded weight total fetal membranes membranes individually measured calculate surface individual total surface per placenta total surface unaffected breed interaction besides lower weight smaller total surface compared respectively within breed fetal membranes lower total weight lower membrane weight compared number found dams growing higher number greater proportion smaller within breed parity effect membrane weight number individual surface found placental efficiency weight total surface similar significantly higher compared dams respectively furthermore seasonal effect placental development found winter spring smaller summer fall main findings present study lactation maternal growth gestation comparable nutrient constraint alter placental development however results suggest placenta able manage situation two potential compensation mechanisms early pregnancy placenta cope establishing higher number late gestation compensatory expansion surface suggested meet nutrient demand fetus
paper discusses possibilities using non relational databases data data area traditionally covered relational databases authors highlight potential benefits using non relational databases nosql technology based main characteristics classical relational data base management system based paper outlines creation production process using nosql data develops requirements technology necessary processes based practical experience implementing nosql data since currently exist shelf reporting solutions nosql data authors develop requirements reporting solution necessary nosql based
aim work study thermal flux multilayer insulation specimen whose final panels designed green building field specimen fabricated using expanded base milk fibers scattered surface smoothing dimensions specimen need analyze reduced surface development visualization follows computational aspect limit number degrees freedom solved specifically research focused comparative analysis among numerical simulations data processing means matlab using finite difference method domain using finite element method fem domains addition experimental analysis centred detecting sub superficial means infrared technique carried specific matlab also implemented finally observed allows visualization flow done matlab also entire specimen geometry possibility realizing video thermal transient heating cooling phases
objective identify factors associated treatment modality selection acoustic study design prospective observational study setting tertiary care clinic patients data prospectively collected patients initially presenting tertiary care clinic patients magnetic resonance imaging mri demographic psychometric data excluded analysis intervention demographic information clinical symptoms tumor characteristics psychometric data collected determine factors associated undergoing acoustic surgical resection using univariate multiple logistic regression analysis main outcome measure decision pursue acoustic surgical resection versus active surveillance results total patients acoustic mean age years women included ninety eight patients pursued surgical resection patients pursued active surveillance surgical treatment significantly associated patient age less higher grade tumors growing tumors larger volume tumors lower word discrimination scores class hearing headache presenting symptoms higher number total symptoms higher headache severity scores significant association surgical intervention preoperative quality life depression self esteem scores multiple logistic regression analysis likelihood undergoing surgical resection significantly decreased patients older age odds ratio increased patients medium moderately large large grade tumors tumor growth present class hearing higher headache severity scores confidence interval likelihood undergoing surgical resection completely predictive giant grade tumors significant small grade tumors class hearing conclusions non elderly acoustic patients larger tumors growing tumors significant hearing loss worse headaches likely pursue surgical resection rather active surveillance psychological factors quality life depression self esteem seem influence decision making patient population
glomerular visceral epithelial cells play critical role maintenance glomerular injury proteinuria cause many glomerular diseases reported previously calcium independent phospholipase complement mediated glomerular epithelial cell injury studies mice demonstrated important role mitochondrial lipid turnover membrane structure metabolism aim present study employ mice better understand role normal glomerular function glomerular injury show deletion cause detectable however resulted mitochondrial structural abnormalities enhanced autophagy loss aging mice moreover induction anti glomerular membrane young mice mice exhibited significantly increased levels injury loss compared wild type thus protective functional role normal understanding role glomerular pathophysiology provides opportunities development novel therapeutic approaches glomerular injury proteinuria
mounting evidence across taxa females breeding competitive environments tend allocate testosterone offspring offspring typically aggressive faster growing phenotypes date study determined mechanisms mediating maternal effects influence offspring phenotype however levels estrogen receptor alpha gene expression linked differences early growth aggression thus maternal hormones alter gene regulation perhaps via dna methylation offspring prenatal development performed pilot study examine natural variation testosterone allocation offspring egg wild eastern varying breeding densities percent dna methylation promoter offspring brain regions associated growth behavior hypothesized breeding density positively correlated testosterone prenatal exposure maternal derived testosterone associated greater offspring growth decreased promoter methylation testosterone concentration positively correlated breeding density growth rate percent dna methylation one five investigated cpg sites site promoter none percent dna methylation cpg site positively correlated growth rate data suggest possible role epigenetics mediating effects maternal environment offspring phenotype experimentally examining mechanism larger sample size future studies help elucidate prominent way animals respond environment determining mechanisms mediate maternal effects begin understand potential heritability mechanisms impact maternal effects capable producing evolutionary scale
united nations launched global strategy womens childrens health accelerate progress maternal child health commission information accountability established ensure accountability womens childrens health outlined framework three processes monitor review act paper assesses progress processes effective monitoring depends functional civil registration vital statistics system review requires counting deaths identifying contributing factors final critical step action prevent similar deaths maternal death surveillance response includes steps accountability strategies underway improve accountability severe maternal morbidity perinatal mortality post agenda adds greater focus reducing inequalities increasing availability quality data accountability human rights agenda requires engagement communities health providers foundation accountability womens childrens health published elsevier ltd
method consecutive collected enable microscopy applications tissue histology enrichment rna gene expression using adjacent regions single mouse skeletal muscle typically challenging achieve adequate small skeletal muscle samples buffer volumes low efficient applications yet without sufficient mechanical disruption dense tissue architecture muscle limits penetration buffer reagents ultimately causing low rna yield following protocol reported sections collected pooled allowing subsequent needle mechanically disrupt muscle increasing surface area exposed buffer penetration primary limitations technique requires relatively low throughput however high quality rna obtained small samples pooled muscle making method accessible many different skeletal muscles tissues furthermore technique enables matched analyses tissue histopathology gene expression adjacent regions single skeletal muscle measurements directly compared across applications reduce experimental uncertainty reduce animal experiments necessary source small tissue multiple applications
paper presents design implementation cellular automata model predicts damage tools due fatigue transition rules model developed basis known information regarding crack initiation propagation coefficients model determined inverse analysis thermal fatigue tests performed simulator special device rotating disc model coupled conventional wear model layers cell space contact removed successively following wear tool model connected finite element programme simulates stresses tools since multiscale approach appeared extremely demanding far computing times considered efficient implementation model heterogeneous hardware architectures prepared results simulations compared industrial data good predictive capabilities model confirmed published elsevier behalf
embedded class processors found commodity computers continue become increasingly capable moreover wireless connectivity systems provides new opportunities designing flexible wireless sensor networks wsns paper present self organizing wireless sensor network framework leveraging systems sensor provides fundamental functionality make managed wsn system implementation second describe mobile distributed grid like computing engine commodity platforms combination provides sensor nodes capable collecting recording processing communicating data without central server support significant energy savings achieved light medium weight tasks combined system compared traditional server class grid solutions demonstrate context life cycle building energy usage elsevier ltd rights reserved
background objective first class oral pharmacologic treatments overactive bladder oab associated poor persistence anticholinergic adverse events increased anticholinergic burden risk cognitive impairment agonist oral treatment contribute early evidence improved persistence objective analysis assess cost effectiveness oab six methods markov state transition model assessed commercial health plan medicare advantage perspectives year time horizon oab patient population transition probabilities five five incontinence severity states derived network meta analysis trials oral oab treatments therapy beginning oral oab agent switch another oral agent followed tibial nerve stimulation sacral neuromodulation primary outcome cost per quality adjusted life year utilities mapped incontinence frequencies demographics based analysis data large healthcare system elevated associated increased healthcare utilization probability cognitive impairment results commercial medicare advantage perspectives clinically effective treatment least expensive immediate release also cost effectiveness analysis estimated costs per commercial health plan medicare advantage perspectives respectively compared dominated conclusions analysis estimated cost effective treatment oab commercial health plan medicare advantage perspectives due fewer projected adverse events comorbidities data suggesting better persistence
order enhancement stealth capability ship electric fields similar characters ship electric magnetic fields produce mechanism studied similar effect characters effectiveness ship electric magnetic fields analyzed communicate theory ship electric magnetic fields researched similar characters analytical methods stealth technology strategy ship electric magnetic fields discussed shown stealth technology ship electric magnetic fields similar research developed methods experimentation
widely used instantaneous unit based nash cascade reservoir model obtained zero initial condition empty reservoir assumption study general case non zero initial condition considered derivation classical nash model generalized nash model deduced using laplace transform principle mathematical induction river flow routing physically formation downstream outflow summation flow initial channel storage response upstream inflow written state space representation able update state river system time hence applied real time forecasting two separate case studies used illustration indicated proposed updating procedure results improved river flow forecasts compared traditional method elsevier rights reserved
report two newborns female external bilateral swelling diagnosed beta dehydrogenase type deficiency rare cause disorder sexual development first case normal size vaginal region low testosterone low levels basal stimulated second case similar external low testosterone borderline basal normal stimulated levels low testosterone ratios respectively normal human stimulation indicated beta dehydrogenase type deficiency sequencing revealed homozygous novel mutation exon first case homozygous exon second
global map drought risk elaborated sub national administrative level motivation study observation little research efforts made global level provide consistent drought risk management framework multiple regions population groups economic sectors drought risk assessed period based product three independent determinants hazard exposure vulnerability drought hazard derived non parametric analysis historical precipitation deficits drought exposure based non parametric aggregation indicators population livestock densities crop cover water stress drought vulnerability computed arithmetic composite high level factors social economic indicators collected national sub national levels performance evaluation proposed models statistical robustness emphasizes empirical geographic patterns potential drought impacts previous results presented literature findings support idea drought risk driven exponential growth regional exposure hazard vulnerability exhibit weaker relationship geographic distribution risk values drought risk lower remote regions tropical forests higher areas regions extensively exploited crop production livestock farming south central asia southeast south america central europe southeast united states climate change projections increase drought frequency intensity regions risk global food security potential civil conflict medium long term since agricultural regions show high vulnerability drought regional adaptation climate change begin implementing fostering widespread use irrigation rainwater harvesting systems context reduction drought risk also benefit regional different sectors activity reducing dependence agriculture european commission published elsevier ltd
viruses associated important economic losses china therefore comprehensive survey sample collection performed growing seasons major growing locations largest area production china samples analyzed using reverse transcription polymerase chain reaction pcr detect mosaic virus yellow mosaic virus mosaic virus virus mosaic virus tomato virus mosaic virus tomato virus silver virus green mosaic virus yellow virus collected samples virus like symptoms samples infected least one viruses prevalent virus detected detected infected samples respectively infection rate three viruses changed significantly among cultivars viruses analysed detected sample tested number multiple infections high average common double infection closely followed statistical analysis potential association among viruses showed strong association several viruses multiple infections analysis genetic diversity suggested isolates obtained study clustered group selection restricting variability population
economic environmental benefits brought electric vehicles evs fully delivered unless vehicles fully partially charged renewable energy sources res photovoltaic system nevertheless charging management problem station integrated res challenging due uncertain nature local res generation paper aims address difficulties deploying energy storage system stations exploiting charging scheduling evs achieve better utilization intermittent charging real time charging optimization scheme also formulated using mixed integer linear programming coordinate charging power evs along power power grid based vehicles charging priorities electricity price preferences extensive simulations show proposed approach maximizes satisfaction owners terms fulfilling charging requests also minimizes overall operational cost station utilization energy scheduling every evs charging
japanese government approved use oral contraception users remain small minority japan using results online survey conducted examine factors determining japanese womens choice contraceptive method estimating multinomial choice models estimation results indicate use positively associated age willingness pay contraceptive effectiveness frequency intercourse experience abortion emergency contraception findings suggest use increases women learn experience low declining frequency intercourse japan offers one explanation slow diffusion additionally findings indicate use prevalent among women higher risk unintended pregnancies subjective probabilities regarding contraceptive methods contraceptive effectiveness disruption romantic partner side benefits minor non life threatening side effects important determinants contraceptive choice perceived risk levels side effects significantly higher population based probabilities implying increased medical knowledge increase use
marker basal progenitor cells number organs prenatal development gland mice progenitor cells developing play important roles although cells also present adult mouse function tissue regeneration histological localization yet investigated detail present study examined immunohistochemical localization adult postnatal developing mice birth immunoreactivity detected entire duct system localized basal cells double layered epithelium detected terminal cells postnatal weeks development immunoreactive basal cells gradually restricted proximal double layered portions connecting time immunoreactivity appeared cells positive ratio gradually increased adults immunoreactivity localized cells basal cells small number cells boundary female granular male results suggest marker differentiated cells duct progenitor cells mouse
paper presents framework structural health monitoring shm damage identification civil structures framework integrates advanced mechanics based nonlinear finite element modeling analysis techniques batch bayesian estimation approach estimate time invariant model parameters used model structure interest framework uses input excitation dynamic response structure updates nonlinear model structure minimize discrepancies predicted measured response time histories updated model detect localize classify quantify state damage predict remaining useful life structure opposed recursive estimation methods batch bayesian estimation approach entire time history input excitation output response structure used batch data estimate model parameters number iterations case non informative prior batch bayesian method leads extended maximum likelihood estimation method estimate jointly time invariant model parameters measurement noise amplitude extended estimation problem solved efficiently using gradient based interior point optimization algorithm gradient based optimization algorithms require response sensitivities respect model parameters identified response sensitivities computed accurately efficiently using direct differentiation method estimation uncertainties evaluated based lower bound theorem computing exact fisher information matrix using response sensitivities respect model parameters accuracy proposed uncertainty quantification approach verified using sampling approach based transformation two validation studies based realistic structural models bridge moment steel frame performed validate performance accuracy presented nonlinear model updating approach demonstrate application shm validation studies show excellent performance proposed framework shm damage identification even presence high measurement noise way initial estimates model parameters furthermore detrimental effects input measurement noise performance proposed framework illustrated quantified one validation studies elsevier ltd rights reserved
introduction therapy remains effective treatment major depressive disorder since texas maintained database including patient diagnoses outcomes reporting deaths within days receiving treatment encompassing total treatments administered texas previously period methods descriptive analysis summarized information deaths reported year period cause death type treatment index maintenance patient demographics multiple logistic regression death incidence treatment session performed determine whether patient age sex race diagnosis year treatment associated death results deaths occurring within day treatment death rate per treatments looking deaths within days treatment death rate increased per treatments included deaths regardless likelihood causal association example accidents latter leading cause death among individuals severe major depression disorders indicated death rate increased significantly increasing patient age male sex nonsignificant trend toward increased death amongst bipolar disorder schizophrenia versus depression conclusions data indicate general safe procedure respect likelihood immediate death suicide remains significant risk patients despite evidence reduces suicidal ideation
current research suggests incidence heterogeneity autism spectrum disorder asd symptoms arise variety exogenous endogenous factors subject routine clinical practice generally considered safe exists though human data diagnostic ultrasound also contribute asd severity supported experimental evidence exposure ultrasound early gestation brain development alter behavior explored modified triple hit hypothesis assay possible relationship severity asd symptoms ultrasound exposure first trimester pregnancy fetuses genetic predisposition asd using retrospective analysis data simplex collection autism genetic repository funded foundation autism research initiative found male children asd copy number variations exposure first trimester ultrasound significantly decreased non verbal increased repetitive behaviors relative male children asd ultrasound data suggest heterogeneity asd symptoms result least part exposure diagnostic ultrasound early prenatal development children specific genetic vulnerabilities results also add weight going concerns expressed fda non medical use diagnostic ultrasound pregnancy autism international society autism research wiley periodicals inc
algorithm wave method structural health monitoring shm tested calibrated using table experiment data full scale seven story reinforced concrete building slice method based monitoring changes velocity waves propagating vertically structure identified least squares fit beam models experiment conducted team university california san network earthquake engineering simulations outdoor table ambient noise white noise earthquake response data four progressive damage states analyzed algorithm tested first time highly dispersive wave propagation damaged structure much shorter segments ambient vibration data used previously structure modeled beam large shear stiffness wave velocity identified change measured different damage states compared change fundamental frequency vibration effectiveness method discussed american society civil engineers
aircraft power generation system constant speed drive integrated drive generator play important part provide constant frequency power supply aircraft electrical systems however systems particularly heavy fully mechanical tendency fail completely linkages break aircraft engine much lower cycles per second required produce standard frequency aircraft electrical system power supply paper variable speed constant frequency aircraft power generation system based high number input phases matrix converter proposed system tested engine prime engine performance based typical flight profile aircraft proposed aircraft power generation system constant frequency output validated using modeling simulation matlab simulink
individuals half likely heterosexual counterparts report religious identity gay lesbian bisexual emerging adults maintain religious identity affiliation throughout adolescent young adult years challenge dominant narratives sexuality religion study demographic findings considers impact family life sexual identity authors present data qualitative interviews individuals ages results presented model describing participants constructed identity perceive acceptance identities families communities
transforming land land effective approach cope problems including shortage severe soil erosion paper introduces new system based rainwater harvesting recycling technology effectively improve productivity rainwater use efficiency reduce water fertilizer inputs new system consists three subsystems layer dual function crop cultivation rainwater harvesting tank layer storing water irrigation drainage subsystem layer storage tank treated reducing connected irrigation drainage system results showed compared traditional fields rice crop coefficient test field remained similar level irrigation amount reduced condition basin irrigation drainage amount decreased non point source pollution reduced similar rainwater utilization efficiency increased reached crop yield middle season rice reached lower traditional field terms dry matter new technology sheds light new possibilities transformation land
ambient intelligence one research area wireless sensor devices commonly used main idea applications monitor recognize peoples indoor outdoor activities study focus one major problem wsn energy consumption different way existing approaches literature proposed approach shown possible create dynamic sleep scheduling mechanism recognized activity contrast previous studies found literature review perspective holistic approach takes component application level account proposed therefore energy consumption ways improving lifetime node network handled main aim find suitable region application work performance degradation meanwhile lifetime sensor extended decreasing energy consumption proposed approach tested accelerometer signal walking activity shown exists region application performance energy gain suitable
flat enzyme based lactate cell integrated power management system developed potential power supply wearable sensors kinetic models power output chemical reagent concentration lactate oxidase lactate developed determine limiting factor performance given lactate concentration human optimum amount coated anode ranged based experimental maximum power output entity simulation test power discharge recharge frequency calculated self sustained sensing data transmission indicating support wearable sensors power requirement signal transfer frequency times electrochemical activity coated anode validated using cyclic voltammetry coefficient variance regression statistical analysis revealed high stability long lifespan weeks without need lactate published elsevier ltd
aim study aimed evaluate benefits post operative blood loss production women undergoing unilateral total administering dilution materials methods women randomly assigned placebo followed days main end point reduction blood serum volumes collected secondary end points duration drainage self evaluation pain presence results per protocol analysis revealed lower mean volume blood serum collected confidence interval regression model including treatment volume collected drainage day surgery patient weight showed statistically significant difference favor volumes collected day surgery following days significantly lower days secondary end points revealed significant differences conclusions reduce post operative blood collection women undergoing unilateral total larger studies needed different validate data
objective osteopenia chronic bone condition characterized decreased calcification density bone mass untreated lead osteoporosis bone fractures although increasing prevalence nowadays osteopenia adequately prevented managed study evaluated efficacy term changes bone density safety oral formulation based subjects suffering low bone density patients methods otherwise healthy subjects low bone density enrolled pilot supplement study informed participants freely decided follow either standard management control low bone density control group associated based oral supplementation supplement group bone densities small finger upper evaluated inclusion different time points observational period weeks subjects results bone density measured remarkably improved supplemented group significant decrease transmission values week week compared baseline values bone densities small finger upper also significantly increased study supplemented subjects reaching respectively week respect values inclusion noteworthy significant changes small finger upper densities observed control group last safety tolerability issues reported observational period conclusions preliminary study suggests based supplementation combination appropriate lifestyle beneficial prevention management osteopenia
background syndrome associated substantial morbidity mortality consensus however mortality risk stratification aimed investigate survival predictors death large contemporary cohort syndrome patients methods multicenter approach identified adults syndrome follow examined survival association clinical laboratory parameters results studied patients median age years range years female syndrome majority defect followed patients complex lesion median follow years interquartile range allowing patient years observation patients died underwent transplantation twelve parameters emerged significant predictors death analysis multivariable cox regression analysis age hazard ratio years confidence interval shunt oxygen saturation rest presence sinus rhythm presence remained significant predictors death conclusions significant premature mortality among contemporary adults syndrome report multivariable mortality risk stratification model based simple noninvasive predictors death population
computationally intensive digital signal processing dsp systems sometimes real time requirements beyond programmable processor platform solutions consisting dsp processors achieve addition field programmable gate array fpga components platforms provides configurable hardware resource increased parallelism levels allow large computational rates techniques implement circuit architectures signal flow graph sfg algorithm expression produce highly efficient processor implementations applying folding transformations produces implementations hardware resource usage reduced possible expense throughput paper new development methodology presented analyses sfg algorithm suggest appropriate folding techniques characterizing different folding techniques template circuit architecture created early design process alter throughout implementation process techniques applied algorithm sfg produces properly timed implementation template applying methodology architectural exploration quickly efficiently performed generate set implementations implementation space best meet constraints system applied lattice filter design example results demonstrate high savings fpga resource usage little reduction real time performance demonstrating implementation advantage employing methodology
class native compound numerous biological activities exert protective effect postmenopausal bone loss however remains unknown whether regulates osteogenic differentiation bone marrow stromal cells treatment prevention osteoporosis study treated various concentrations stimulate osteogenic differentiation day period additionally canonical ovariectomized mouse model used evaluate effect month treatment preventing postmenopausal osteoporosis vitro found promotes alkaline phosphatase activity staining red assay stimulated expression osteogenic markers related transcription factor osteocalcin vivo trabecular number trabecular thickness trabecular bone mineral density distal femoral significantly increased mice treated months compared mice treated moreover expression mice significantly increased mice finally found activated wnt beta catenin pathway expression several downstream genes including cell factor lymphoid enhancer factor inhibition wnt beta catenin pathway related protein blocked positive role therefore promoted osteogenic differentiation wnt beta catenin signaling
paper presents new pole zero assignment based design method two degree freedom pid controller applicable positioning tracking drives linear servo motors method uniquely determine five pid control parameters giving five items namely mass maximum load mass thrust constant cutoff frequency position control system crossover frequency sensitivity complementary sensitivity functions pole angle plane simulation experimental results validate proposed method
androgen deficiency occurs frequently men human immunodeficiency virus hiv infection antiretroviral treatments reduced prevalence male hypogonadism pathogenesis testosterone deficiency hiv multifactorial several mechanisms proposed among drugs fat redistribution poor health status explain mechanism leading inhibition hypogonadism diagnosis hypogonadism hiv infected men made based clinical symptoms specific including measurement interpretation results biochemical testing difficult men hiv due several confounding factors treatment offered hiv infected men documented clinical hypogonadism symptoms especially losing lean mass
summarized first article continuing medical education series currently available epidemiologic data suggest psoriasis risk factor cardiometabolic disease emerging data also suggest associations psoriasis comorbidities beyond psoriatic arthritis including chronic kidney disease inflammatory bowel disease hepatic disease certain malignancies infections mood disorders recognizing comorbid disease burden psoriasis essential ensuring comprehensive care patients psoriasis clinical implications comorbid diseases associated psoriasis recommendations clinical management reviewed article
background purpose studies examined patients dementia stop attending medical consultations conducted retrospective study investigate factors associated discontinuous clinic attendance methods participants patients dementia university hospital clinics affiliated local hospital clinics compared continuous discontinuous cognitive affective functions activities daily living also compared patients continuous discontinuous continuous discontinuous results total annual rate discontinuation mean period attendance discontinuation years scores mini mental state examination dementia scale revised geriatric depression scale scale behavioral psychological symptoms dementia score significantly worse discontinuous group continuous group patients best predictor discontinuation decline score common reason discontinuation returning family doctor cessation hospital attendance conclusions identified main reasons discontinuation attendance returning family doctor cessation hospital attendance best predictors discontinuation decline worsening significant differences discontinuation patients dementia
purpose ambient light stimulus visual function regulator physiology however known light regulate aspect development purpose study investigate whether ambient light required development mouse rod methods newborn mouse pups either cyclic light constant dark pups collected postnatal day performed retinal morphometric cell death analysis expression assessed using immunofluorescence western blot quantitative pcr analysis performed elisa used follow changes thyroid hormone levels serum results pups outer nuclear layer significantly thinner higher numbers apoptotic cells compared pups expression lower pups waves reduced amplitude pups animals lower levels circulating thyroid hormones light mediated changes thyroid hormones occur early detected lower levels total triiodothyronine animals drug induced developmental hypothyroidism resulted lower expression conclusions data demonstrate light exposure postnatal development required rod development effect mediated thyroid hormone signaling
purpose literature review examine available clinical studies performed last years identify causal relationship onset course autoimmune thyroid diseases hypothalamic pituitary adrenal hpa axis sympathetic system sam function women using pubmed web science scopus databases comprehensive search performed articles finally identified majority selected studies suggested causal connection disease stress thyroiditis variant postpartum thyroiditis stress however due heterogeneity protocols mainly based theoretical side effects stress immune neuroendocrine system different modalities used establish impact stress individuals definitive conclusions reached explain mechanisms stress contributes onset women determine whether stress management help modifying course
recent educational policy raised standards students including students disabilities meet mathematics examine strategies currently used support students learning disabilities authors reviewed literature mathematics interventions students learning disabilities articles reviewed contain various instructional focuses including systematic instructions problem based instruction visual representation review includes discussion interventions used including success interventions used students disabilities students without disabilities implications practice future research also discussed including need continued research middle high school interventions address variety mathematical skills concepts
expect number internet things iot devices rapidly increase part due availability low cost powerful hardware advances hardware introduce new class computer commodity low cost single board computer example devices capable running full operating system accessible non technical users paper demonstrate feasibility using class computer construct iot devices without deep technical knowledge embedded systems iot device targeted real world data collection basis deployed device discover although existing hardware market varies dramatically much applicable iot scenarios generally default box configuration supports one linux variants programming languages standard hardware libraries configurable predict growth using class computer particularly iot prototypes compute low hardware volume scenarios future expect hardware improvements enhanced operating systems taking account issues surrounding iot devices card storage power consumption improved failure detection
aim paper show results various experimental tests carried synchronous reluctance motors different rotor geometries proposed technical literature impact assistance permanent magnet flux barriers considered assisted motors compared synchronous motors highlighting main benefits former solution effect rotor adopting asymmetric geometries flux barriers reduce torque ripple investigated means several tests impact also considered far overload capability concerned addition experimental tests finite element model adopted predict performance motors predicted results compared experimental ones wide operating range showing good agreement
recently artificial intelligence used widely medicine health care sector machine learning classification prediction major field today study existing predictive models based machine learning methods extremely active doctors need accurate predictions outcomes patients diseases addition accurate predictions timing another significant factor influences treatment decisions paper existing predictive models medicine health care critically reviewed furthermore famous machine learning methods explained confusion statistical approach machine learning clarified review related literature reveals predictions existing predictive models differ even dataset used therefore existing predictive models essential current methods improved
anticipation ethical issues arise clinical use genomic technologies crucial future implementation manner sensitive local contexts yet populations low middle income countries studies aim explore stakeholders perspectives use technologies within framework research project entitled personalized medicine treatment epilepsy sought increase reach survey around world share views practices regarding use whole genome sequencing clinical neurology associated ethics discuss herein compelling scientific ethical reasons led attempt recruit worldwide despite lack many low middle income countries access genomic technologies recruitment procedures results presented discussed barriers faced conclude inclusive recruitment remains challenging albeit necessary legitimate
study investigate properties flexible strain sensitive multi walled carbon nanotubes epoxy composites deformation sensor area tested digital image correlation quasi static tension characteristics films investigated quantitatively electrochemical impedance spectroscopy eis wide range frequencies mhz scanning electron microscopy sem images confirmed epoxy composites different concentrations good homogeneity dispersion additionally order tailor strain sensor equivalent circuit derived based impedance responses corresponding parameters extracted tensile strain compared traditional strain higher sensitivity obtained particular concentrations close threshold due tunneling effect non linear observed low concentrations found sensors shows highest linearity correlation coefficient standard deviation cyclic readings found indicating high repeatability elsevier ltd rights reserved
personalized medicine group belongs laboratory molecular biology immunology department pharmacy active since mainly field personalized medicine herein describe research interests collaborations personalized medicine group together teaching activities group greatly enhance knowledge graduate students healthcare professionals
background aims sensitive skin frequently reported condition western world suggested impaired skin barrier aim study investigate skin barrier molecular composition subjects using confocal raman compare non individuals atopic dermatitis allergic subjects frequently report methods subjects included stratum thickness water fatty acids natural factor measured along water loss capacitance ventral levels additionally measured results differences subjects found regarding thickness water content yet trend towards lower fatty acids observed compared subjects group showed higher fatty acid content whereas differences emerged correlation macroscopic biophysical techniques weak yet confirmed known lower content water thinner subjects mutations conclusion skin barrier impaired terms thickness water fatty acid content failure biophysical techniques follow alterations molecular composition skin barrier revealed emphasizes strong need sensitive specific tools vivo skin barrier analysis karger basel
study investigates use social networks scientific tool gathering medical data young subjects promoting healthier habits first hypothesis social networks facilitate epidemiological studies reducing time cost second question whether social networks enable collection data young healthy subjects otherwise beyond reach conventional social health facebook application created collect data concerning adherence mediterranean diet considering significant risk cardiovascular neurological degenerative diseases subjects poor adherence healthy diet users recruited short time without action collected data indicate adherence mediterranean diet general greater older users young italian countries mainly participants statistical differences found concerning gender results show proposed approach offers advantages terms reduced cost faster data gathering processing improved efficiency compared form based epidemiology campaign however initial network influence sample age geographical location especially spread become viral autonomous based case study provide designers facebook apps simple guideline suggestions aimed maximizing heterogeneity sample order collect significant data proposed scenario suitable collecting health data easily extended fields
sclerosis complex rare multi system disorder primary manifestations benign tumors lesions various organs body including brain patients often suffer epilepsy mental retardation autism spectrum disorder asd therefore serves model epilepsy asd tumorigenesis caused lack functional complex serves major cellular inhibitor mammalian target rapamycin complex kinase controlling processes eukaryotic cells consequently inhibitors rapamycin serve experimental already approved drugs several symptoms however although quite effective need administered chronically likely lifetime since therapy discontinuation results tumor epilepsy recurrence recent studies revealed metabolism excitability case neurons cells lacking complex changed features potentially used treat symptoms review first provide basic facts molecular background next discuss findings cell biology used improve existing therapies diseases linked authors life published wiley periodicals inc behalf international union biochemistry molecular biology
background study aimed examine associations age presence complications glycemic control northwest iran methods total people diabetes years old caring record diabetes clinics two provinces iran recruited cross sectional study general information including demographic socioeconomic status lifestyle factors collected trained clinical information retrieved clinics record univariate multivariate logistic regression performed assess predictors diabetes outcome interest clarify role age relation outcomes results compared age group years disease record times likely complications conclusion although prevalence complications higher among older diabetic patients better glycemic control influential factors associated two diabetes related outcomes therefore comprehensive risk profiles assessment needed glycemic control
purpose review provide overview visual provide information regarding current treatment options visual rare disorder persistent visual phenomenon seeing numerous like dots throughout visual field cause debilitating visual psychological consequences emerging disorder separate associated migraine visual aura neuronal cortical considered theoretical mechanism persistent positive visual symptoms studies investigated treatment understanding entity begins change expect new treatment approaches treatment trials emerge next decade currently approach consider pharmacologic treatment patients report decreased quality life result resolution disorder difficult accomplish treatment experience even symptom intensity simply reduced many patients find improvement quality life beneficial preferred treatment options include oral slow increase daily maintenance dose daily divided doses tolerated typically achieved advancing dose weekly following first weeks therapy oral initial dose daily followed slow increase weeks total daily divided doses higher doses tolerated without increasing risk benefit ratio oral daily side effects limit dose initiated lower doses short acting two three times daily substituted higher doses long acting formula tolerated initiating drug treatments low doses slowly increasing weeks tolerability compliance improves allows patients realize full benefits treatment proposed mechanisms microstructural cortical abnormalities cause lead new treatment approaches future time medications reported relieve persistent visual phenomena migraine visual aura migraine treatment options worth considering reviewed purpose although clinical trials treatment visual lacking due disorder medications reviewed considered use patients experience impact quality life theoretical mechanisms lead cortical investigated lead new treatment options medications provide benefits disabling condition
health care associated infection rates subject public reporting linked hospital reimbursement centers medicare medicaid services cms increasing pressure lower rates comes time advances clinical microbiology laboratory cml provide precise sensitive tests altering detection ways increase reported rates review changing cml practices impact rates financial implications metrics produce pressure change diagnostic testing practices finally provide suggestions respond rapidly changing environment
soil evaporation important component water balance irrigated agriculture effective technique reduce soil evaporation efficiency depends meteorological conditions characteristics different materials objective work assess effectiveness inorganic plastic organic pruning residues geotextile wheat materials soil evaporation control energy limited falling rate evaporation stages soil evaporation rates quantified consecutive initially wet soils placed laboratory field depended meteorological experimental conditions stage evaporation type material falling rate stage decreased linearly decreases long drying periods low similar among treatments implying soil ineffective soil evaporation control low frequency irrigation systems energy limited stage materials decreased relation bare soil plastic residues materials lower rest materials materials therefore recommended soil evaporation control high frequency irrigation systems soil surface remains wet time elsevier rights reserved
purpose purpose work adapt lightweight permanent magnet electron energy spectrometer measurement energy spectra therapeutic electron beams methods irradiation geometry measurement technique developed approximately permanent magnet spectrometer produce suitable latent images computed radiography strips dual electron created diameter approximately parallel beam incident spectrometer appropriate dose rate image plane strip location ray background latent image reduced thick lead block removed using fitting technique theoretical energy dependent detector response functions used iterative technique transform strip net mean dose profiles energy spectra central axis entrance spectrometer spectra transformed spectra source distance correcting energy dependence electron spectrometer calibrated comparing peak mean positions net mean dose profiles initially peak mean energies determined practical range central axis percent depth dose curves peak mean energies accounted modified energy spectra utility spectrometer demonstrated measuring energy spectra seven electron beams infinity radiotherapy accelerator results plots illustrated dependence energy position imaging plane approximately iterations solved energy spectra spectrometer entrance measured net mean dose profiles transforming spectra ones increased low energy tail spectra correspondingly decreasing peaks shifting slightly lower energies energy calibration plots peak mean energy versus peak mean position net mean dose profiles seven electron beams followed shape predicted lorentz force law uniform component magnetic field validating modeled uniform measured energy spectra peak mean energies correlated curves full width half maximum energy spectra decreased decreasing peak mean energy exception beam wide similarly decreased linearly peak mean energy exception beam attributed suboptimal tuning high power phase recycled power traveling wave accelerator conclusions apparatus analysis techniques authors demonstrated inexpensive lightweight permanent magnet electron energy spectrometer used measuring electron energy distributions therapeutic electron beams primary goal future work develop real time spectrometer incorporating real time potential applications beam matching ongoing beam tune maintenance measuring spectra input monte carlo beam calculations american association medicine
design complex systems software architects deal abstract measures ideas discover fitting underlying architecture common way structure complex systems terms interacting software components whose composition connections need properly adjusted along expected functionality non functional requirements key stage guide many design alternatives evaluated software architects appearance search based software engineering brings approach supports software engineer along design process evolutionary algorithms applied deal abstract highly combinatorial optimisation problem architecture discovery multiple objective perspective definition resolution many objective optimisation problems currently becoming emerging challenge application sophisticated techniques within evolutionary computation field needs considered paper diverse non functional requirements selected guide evolutionary search leading definition several optimisation problems metrics concerning architectural empirical study behaviour multi many objective evolutionary algorithms presented quality type returned solutions analysed discussed perspective evolutionary performance aspects interest expert results show many objective evolutionary algorithms provide useful mechanisms effectively explore design alternatives highly dimensional objective spaces
propose novel method conceptualized properties physics particular shape flame determined temperature enables control mechanism intuitive shaping flame focused trade issue computer graphics whereby turbulent flow expresses characteristics flame tendency shift continuously whereas velocity constraints contain fluid within target shape tendency force movement particular direction trade made difficult animation designers maintain flame within intended target shape paper issue enabling flame controlled without velocity constraints using following two techniques first model temperature force explosion generated combustion explosive gaseous fuel apply certain regions second expand space interface fuel products classifying space four regions controlling target shape flame delicate adjustments temperature region experiments show flame maintains appearance dynamic movement preserving detailed shapes specified scene designers
highly polymorphic major histocompatibility complex mhc termed leukocyte antigen associated different levels immunologic responses infectious diseases vaccines transplantation pig known haplotypes important genetic resources biomedical research canadian pigs represent current specific pathogen free breeding stock maintained isolation environment veterinary research institute chinese academy agricultural sciences study identified alleles five polymorphic loci representing class haplotypes class haplotypes using reverse transcription polymerase chain reaction pcr sequence based typing pcr sequence specific primers methods canadian pigs official alleles assigned committee international society animal genetics released updated immuno polymorphism database mhc sequence database release confirmed alleles standardized many previously alleles genbank database three class haplotypes appeared novel previously reported pig populations one crossover within class region two class class regions observed resulting three new recombinant haplotypes presence locus confirmed three class haplotypes furthermore also analyzed functional identified frequent class molecules study confirmed existence four using method results useful studying adaptive immune response immunological phenotypic differences pigs screening potential cell epitopes developing effective vaccines
background individuals intermittent explosive disorder previously found exhibit amygdala relatively reduced orbital medial prefrontal cortex activation angry faces performing implicit emotion information processing task functional magnetic resonance imaging fmri study examines neural substrates associated explicit encoding facial emotions among individuals method twenty subjects twenty healthy matched comparison subjects underwent fmri viewing blocks angry happy neutral faces identifying emotional valence face positive negative neutral compared amygdala reactivity faces subjects also examined relationship amygdala activation aggression severity results compared controls group exhibited greater amygdala response angry neutral facial expressions contrast control groups differ activation angry faces across subjects amygdala activation angry faces correlated number prior aggressive acts conclusions findings extend previous evidence amygdala dysfunction response identification ecologically valid social threat signal processing angry faces among individuals link amygdala hyperactivity social signals direct threat aggression elsevier ltd rights reserved
united states geological survey estimates four crude oil currently trapped within oil however cost effective environmentally sustainable method oil production oil currently exists given continuing demand low cost fossil fuel production alternative methods oil extraction needed fuel cells harness heat generated high temperature solid oxide fuel cells electricity generation process oil sweet crude oil paper thermo electrochemical model simulate performance gross fuel cell module situ oil processing analyzed work prototype contains three solid oxide fuel cell stack assemblies within diameter stainless steel housing high temperature process heat produced electricity generation used oil within underground geological high value oil natural gas steady state system model developed plus using user defined predict stack electrochemical performance heat rejection module model validated empirical data independent single stack performance testing full module experiments following model validation simulations performed different values current fuel air utilization study influence system electrical heating performance model used explore wider range operating conditions experimentally tested provides insight competing physical processes play fuel cell operation results show operating conditions tuned generate desired heat flux conditions needed across applications elsevier ltd rights reserved
temperature one basic biophysical quantity monitored various biomedical systems moreover variation temperature also important parameter used estimating respiratory airflow paper proposes simple operational amplifier based circuit linearization characteristic negative temperature coefficient one timing resistors circuit combined table get unknown temperature value output moreover system topology used measurement respiratory airflow performance composite system verified experimentally linearity approximately achieved degrees degrees case temperature measurement airflow better results also achieved introduction interpolation algorithms higher computational component cost complete system makes good candidate embedded sensing applications biomedical systems point care monitoring sleep study
report fabrication characterization hydrogel improved mechanical dielectric properties cellulose ray diffraction sem observations used analyze sample morphology resulting detector exhibits pronounced change swelling index response variation used combination nanomaterials optimize smart material designs applications developed material anticipated chemical environmental biological systems
network chip enables design high performance low power many core chips existing inadequate meeting ever increasing performance requirements many core processors since simple extensions regular architectures fully exploit advantages provided integration moreover anticipated performance gain enabled many core chip compromised due potential failures silicon predominantly used vertical address problems propose machine learning inspired predictive design methodology energy efficient reliable many core architectures enabled integration demonstrate small world network based performs significantly better mesh based counterparts average shows energy delay product improvement mesh benchmarks considered paper improve reliability propose computationally efficient vertical link allocation algorithm based state space search formulation results show proposed allocation algorithm significantly improve reliability lifetime
psychotropic drug defined drug capable affecting mind emotions behavior drugs used treatment mental illnesses medical health nursing use drugs lead urinary dysfunction often difficult delineate whether urinary dysfunction direct indirect result drug use secondary unrelated concurrent condition situation therefore result diagnostic management psychiatrists primary care physicians article reviews literature published last years provides update desirable undesirable effects psychotropic drugs lower urinary function antidepressant efficacy treatment stress urinary incontinence addition proposed treatment overactive bladder laboratory research potential therapies target role lower urinary tract function progress several antipsychotics antidepressant medications associated urinary retention several antidepressants associated nocturnal furthermore known induce storage symptoms reduction bladder capacity lower urinary tract symptom luts causing drugs associated elderly patients particularly susceptible adverse events due pharmacotherapy awareness psychotropic drug side effects use important avoid undesirable outcomes patients luts psychotropic drugs fail benefit simple first line treatments luts clinicians psychotropic drug indeed cause luts seek patients primary care physician discuss reasonable alternatives
transition compulsive drug use thought occur consequence repeated drug taking leading changes brain circuitry involved emotion cognition basis lie changes expression immediate early genes implicated transcriptional regulation synaptic plasticity intracellular signalling however little known expression patterns change long term drug self administration present study therefore compares effects day self administration cocaine sucrose expression brain regions implicated addictive behaviour dorsal striatum ventral striatum medial prefrontal cortex increased expression cocaine self administration found dorsal ventral striatum fos delta arc striatum plus bdnf five delta bdnf jun responsive long term sucrose self administration importantly major differences found expression patterns days cocaine self administration except delta dorsal striatum whereas amount cocaine obtained per session comparable short term long term self administration steady changes expression therefore associated stable self administration behaviour rather total amount cocaine consumed thus sustained regulation prolonged cocaine self administration changes underlying compulsive drug use
background data capture clinical registries pilot studies often performed based applications like microsoft spss usually data transferred statistic software sas spss statistics analyses afterwards based solutions suffer several drawbacks generally possible ensure sufficient right role management changed data therefore systems able comply regulatory requirements electronic data capture clinical trials contrast electronic data capture software enables reliable secure collection data regard support standard define communicate clinical trial meta patient data advantages systems support multi user multicenter clinical trials data migration based data collection systems labor intensive time consuming present hence objectives research work develop mapping model implement converter spss standard evaluate approach regarding semantic correctness results mapping model spss data structures developed spss variables patient values mapped converted statistical display attributes spss corresponding elements study related elements available spss converting tool implemented command line tool using spss internal java semantic correctness validated different tools reverse transformation spss format clinical data values also successfully transformed structure conclusion transformation format spss standard definition exchange trial data feasible facilitates migration spss based data collections towards reliable systems thereby advantages systems like reliable software architecture secure data collection particularly compliance regulatory requirements achievable
binding protein heat shock protein significantly influences glucocorticoid receptor sensitivity single nucleotide polymorphisms snps gene associated altered hypothalamus pituitary adrenal hpa axis function changes structure function several cognitive brain areas increased susceptibility post traumatic stress disorder major depression bipolar disorder suicidal events mechanisms underlying associations largely unknown influence snps emotional memory systems play role present study participants exposed socially evaluated cold test stress control stress conditions immediately prior learning list words participant memory assessed immediately learning free recall later free recall recognition participants provided saliva sample enabled genotyping three polymorphisms results showed stress impaired immediate recall risk allele carriers importantly stress enhanced long term recall recognition memory non carriers risk alleles effects completely absent risk allele carriers follow analyses revealed memory performance correlated salivary cortisol levels non carriers carriers findings suggest risk allele carriers possess sensitized stress response system perhaps specifically stress induced changes corticosteroid levels aid understanding snps gene confer increased risk stress related psychological disorders related phenotypes
largely due past present receiving certain messages generations regarding heritage western culture facing constant tensions western individual collective constant push pull western cultural values shape reflected daily lives interactions interactions rest world end article discusses wide range factors pertinent americans immigration family structure values parenting gender roles intergenerational issues convey factors need understood context contemporary implications americans experiences also provide discussion values beyond surface talk core value ethnic identity cultural conflicts among need conceptualized discuss legacy influence ethnic identity american families end recommendations researchers service providers hope historically informed understanding americans helpful work population
recent decades discrete event simulation des widely used analyzing construction projects recently fuzzy discrete event simulation integration fuzzy set theory des proposed simulating construction projects provides framework consider subjective uncertainty uncertainty due linguistic expression knowledge construction simulation models current frameworks calculate simulation time project completion time simulation output however performance measures average length waiting time though important simulation model outputs decision making finding bottlenecks optimizing construction resources analyzed current methodologies using fuzzy logic consider subjective uncertainty service time inter arrival time systems improve simulation models representing results paper provides novel methodology consider subjective uncertainty analyzing fuzzy construction models incorporating fuzzy theory methodology proposed paper enhances applicability construction projects proposed methodology validated mathematically solved examples practical aspects illustrated using example asphalt operation elsevier rights reserved
heating demands currently fulfilled conventional technologies based fossil fuels however due rapid depletion environmental hazards fossil fuels focus shifted harness heat energy renewable energy resources solar energy general flat plate tubes collectors used water heating yet another technology known solar thermal tower used heating applications current study focussed real time performance analysis solar thermal tower water heating system climate conditions pakistan initially mathematical model developed design small capacity solar thermal tower system system simulated using matlab five different climate conditions pakistan potential assessment afterwards experimental setup developed consisting cavity type receiver made stainless tubes made mirror complete instrumentation data measurements performance analysis presented terms temperature difference delta absorbed heat efficiency eta fixed variable positions selected days september february results showed maximum temperature difference fixed position degrees maximum efficiency however variable positions maximum value temperature difference achieved degrees resulted efficiency finally reasonable agreement simulated experimental results obtained climate conditions elsevier rights reserved
using nationally representative data individual subjective views gender roles examine gender gap educational achievement turkey show cultural bias education girls fundamental factor behind low educational attainment socially conservative societies education reform turkey extended years using reform natural experiment investigate impact reform effects mothers traditional views determining childrens educational attainment find reform helped reduce school dropout rates across country nevertheless regardless mothers view gender roles reductions school dropout rates similar boys girls failing eliminate gender gap girls turkey excellent environment study effects societal gender roles since combines displays wide spectrum views gender roles also one developing countries gender gap females still exists educational achievement
social make core deficit children autism spectrum disorder asd particular initiated questions social interactions often minimal absent population context multiple baseline design efficacy using motivational procedures pivotal response treatment increase social question asking three young children autism assessed results indicated participants initiated greater number targeted questions following intervention additionally children exhibited increases initiation questions social interaction novel settings furthermore post intervention data revealed gains communication adaptive behavior theoretical implications incorporating motivational strategies intervention improve social young children asd discussed
paper presents modified design approach practical effective neural network efficiency estimation procedure permanent capacitor single phase induction motor standard industrial motor frame sizes along current design trends larger lengths smaller diameters taken account likely presented literature context computer aided design approach based mainly classical output coefficient proposed first numerous simulations using finite elements method fem conducted order verify proposed procedure investigations regarding number stator rotor performed secondly based previous results neural network scheme proposed order estimate efficiency various stator rotor combinations different output power seen proposed methodology verified satisfactorily great use aid tool industrial designers
research evolutionary psychology life history theory particular yielded important insights developmental processes variation growth psychological functioning behavioral outcomes across individuals yet methodological concerns limit ability draw causal inferences human development psychological functioning within life history framework current study used simulation based modeling approach estimate degree genetic confounding tests researched life history hypothesis father absence associated earlier age results demonstrate genetic correlation phenotypic association two variables even genetic correlation small suggesting failure control genetic correlation produce spurious phenotypic correlation discuss implications results research human life history highlight utility incorporating genetically sensitive tests future life history research elsevier inc rights reserved
ambient air pollution becoming severe worldwide serious threat human health fine airborne particles particulate matter show higher cytotoxicity coarse fractions indeed induces cardiovascular respiratory damage however studies evaluated detrimental effect normal human skin used next generation sequencing based rna seq method transcriptome gene ontology enrichment analysis determine harmful influences human normal epidermal keratinocytes analysis showed significantly enriched terms associated epidermis related biological processes epidermis development keratinocyte differentiation suggesting deleterious effects human epidermis addition pathway analysis predicted inflammation related signaling one major induced signaling pathways pro inflammatory cytokines upstream regulators symptoms similar psoriasis downstream effects caused considerable changes expression pro inflammatory cytokines psoriatic skin disease related genes lead epidermal dysfunctions results help understand mechanism air pollution induced skin barrier perturbation contribute development new strategy prevention recovery consequent damage elsevier rights reserved
encounters across difference city spaces marked diverse migration trajectories cultural differences hierarchies captured attention urban scholars concerned challenge living difference promise super diversity many cities expanding approaches focus analyzing conditions good meaningful encounter reduce prejudice promote understanding paper brings interviews asian men australia dialogue bad encounter shows research encounters engage negative encounters become meaningful political occasions right focusing problem sexual racism emerges accounts shared participants paper highlights dating sex important moments aesthetic race gender sexuality shape shared spaces urban life
paper examines conditions global dominant innovation design considering mobility emergence lead market different countries development lead markets linked multiple country specific factors influence lead market potential position decreasing national differences time benefits best compromise internationally similar innovation design due early market entry firms reach first advantages protect especially eco innovations reach state global dominant design developed tackle climate change development globally mobility products electric motor battery whole vehicle likely therefore strategy strengthen lead market mobility seems promising help principal component analysis pca different country specific indicators applied model five lead market factors lead markets change quickly given theoretical concept estimating opportunities forecasting technology developments evaluation usa obtain lead market position according mobility followed germany france advantage usa mainly result demand incentives large sales market germany supply side indicators pronounced position france mainly results advanced supply demand side measures average
paper bilinear method extended new hierarchy variable coefficients result one soliton solution two soliton solution three soliton solutions obtained uniform formula soliton solution derived thanks included functions obtained solutions possess rich local structural features like soliton column soliton shown bilinear method used constructing multi soliton solutions hierarchies nonlinear partial differential equations variable coefficients
paper presents results investigation effect decrease drainage capacity hydraulic deterioration tunnel geosynthetic drainage systems structural performance tunnel use geosynthetics tunnel construction first introduced together summary geotextile filter design principles practices series stress pore pressure coupled finite element analyses carried number tunnel cases order investigate effect hydraulic deterioration tunnel drainage layer structural performance tunnel shown decrease drainage capacity drainage layer significantly increases axial thrust bending moment tunnel pronounced increases bending moment also revealed hydraulic deterioration induced forces tend increase hydraulic head slightly decrease cover depth also shown progressive development hydraulic deterioration induced forces best fit exponential function used predict force increase given tunnel condition practical implications findings discussed
background study aimed investigate central auditory processing performance children migraine compared controls without headache methods twenty eight children sexes aged years diagnosed migraine without aura control group age range headache history included gaps noise duration pattern test synthetic identification test nonverbal test used assess central auditory processing performance results children migraine performed significantly worse test compared controls without headache however significant differences found test conclusions children migraine demonstrate impairment physiologic mechanism temporal processing selective auditory attention short communication migraine related impaired central auditory processing children
attachment anxiety parents associated lower quality parent child relationships inhibited capacity reflect childrens mental states referred reduce parents derive relationships current study explored associations among attachment anxiety parenting satisfaction two groups participants randomly assigned either reflect positive memory child reflect positive memory involving child narratives evaluated positive content using two metrics rated positivity frequency positive emotion words results revealed operated indirectly link attachment anxiety self reported parenting satisfaction groups however served indirect link attachment anxiety coded measures positivity among participants reflected parenting experiences suggesting specificity linking attachment anxiety reduced positivity parenting role results implications understanding influences attachment parents perception parent child relationship quality
introduction aerobic since membership international federation undergone changes regulations objective analyze injuries found spanish aerobic athletes different code points methods descriptive longitudinal comparative study carried epidemiology injuries aerobic published different code points results highlights number injuries decreased last year decline related restriction number difficulties exercise number elements performed floor however increased number value difficulties conclusions therefore concluded changes made regulations intended health athletes ensure competition develops best technical aspect
varying chemical oxygen demand cod concentrations substrate used determine reaction kinetics mass balance organic matter transformation microbial fuel cell mfc mfc chamber volume fed wastewater cod harvest power efficiency respective cod concentration even inhibit biochemical reactions due instantaneous abiotic oxidation high inlet experiments abiotic oxidation revealed maximum oxidation taking place potential removal achieved mfc inlet cod giving around day cod removal conversion facilitating recovery mfc makes interesting pollution technique
remains effective drug therapy parkinsons disease however long term use causes serious side effects induced consistently related derived excessive dopamine release mechanisms addressed clear monoamine oxidase one key enzymes dopamine metabolism therefore involved induced side effects epigenetic modification controls gene transcription investigate effects transcription underlying epigenetic mechanism neuronal cells treated acute days chronic results showed chronic administration resulted dose dependent time dependent downregulation whereas acute administration induced upregulation transcription expression meanwhile chronic exposure induced cpg promoter acute administration caused cpg cpg resulted reactivation transcription results indicated aberrant cpg methylation play key role transcriptional administration addition results showed acute administration induced downregulation dna methyltransferase transcription ten eleven translocation significantly downregulated chronic administration data indicated chronic administration downregulation mediate cpg responsible downregulation transcription contrast acute administration downregulation mediate contributing upregulation conclusion findings suggested mediate aberrant cpg methylation associated administration contribute dopamine release abnormally leading side effects
background stem cell factor implicated many disease processes characterized tissue fibrosis growth factor evaluated rat model serum characterized early inflammation followed later tissue fibrosis methods induced male wistar rats using rabbit anti rat glomerular membrane antibodies animals sacrificed days per group rats kidneys marker inflammation kit mast cell markers fibrosis iii alpha sma changes protein mrna content evaluated western blotting northern blotting respectively results kidney levels immunoreactive receptor kit significantly higher glomerular tubular interstitial compartments mast cells detectable control rat sections double immunostaining showed localization alpha sma receptor positive cells protein compartments glomerular tubular interstitial showed positive linear correlation serum creatinine proteinuria score interstitial fibrosis scores using multivariate analysis tubular predictor glomerular sclerosis glomerular predicted tubular atrophy increased consequence altered transcription fall mrna determined northern blotting western blotting kidney revealed two bands kda band decreased kda band increased throughout study conclusion results highlight potential role receptor process kidney upregulation involve translational mechanism soluble protein kda derived transmembrane protein proteolytic cleavage immunohistochemical staining cells kidneys warrants evaluation nature cells context inflammatory fibrotic processes copyright karger basel
purpose thyroid concentrates radioactive iodine sodium iodide used treating hyperthyroidism thyroid cancer pancreas expresses radioactive iodine uptake damage pancreatic beta cells predispose patients type diabetes aim study determine whether radioactive iodine associated glucose metabolism rats methods forty male wistar rats divided four groups control treated treated thyroxine end study serum fasting glucose insulin thyroid stimulating hormone free measured intraperitoneal glucose tolerance test performed homeostasis model assessment insulin resistance calculated vitro experiments glucose stimulated insulin secretion pancreatic sodium iodide mrna expression thyroid determined results compared control group free lower thyroid stimulating hormone higher groups respectively compared controls rats group glucose intolerance assessed using area curve intraperitoneal glucose tolerance test thyroxine replacement therapy restored value near normal fasting insulin homeostasis model assessment insulin resistance comparable groups however fasting glucose higher group vitro experiments glucose stimulated insulin secretion differ groups conclusion radioactive iodine therapy per effect glucose metabolism just intensified thyroid hormone deficiency alterations glucose metabolism rats thyroxine therapy restored glucose intolerance observed radioactive iodine treated rats
objective estimate prevalence identify associated factors urinary incontinence women method cross sectional study stratified random sample women aged years studied enrolled family health strategy city urinary incontinence investigated using international consultation incontinence questionnaire short form associated factors assessed based self reported questionnaire socio demographic obstetric history morbidities drug use prevalence urinary incontinence estimated confidence interval associated factors identified multiple logistic regression model performed using software version results women mean age years menopause married black brown mean age menopause women years prevalence factors associated urinary loss pregnancy delivery genital stress depression obesity conclusion prevalence lower similar found similar studies factors associated genesis urinary loss pregnancy delivery genital obesity
trees tries degree fundamental data structure particular many text processing algorithms node tree children labeled symbol paper introduce representations dynamic trees nodes requiring bits space first dynamic tree representations support fairly complete set operations using almost optimal space show query operations tree supported time supporting insertions deletions leaves time show set operations supported time case insertions deletions also show associate bit satellite data tree nodes using extra bits finally show machinery introduced dynamic trees adapted represent dynamic binary trees using bits space tree operations supported time case insert operations support adding satellite data tree nodes using extra bits extra bits fastest previous dynamic representation literature providing several trade offs accessing modifying data
objectiveto assess association parental post traumatic stress disorder ptsd offspring ptsd specificity disorders non clinical epidemiological cohort australian veterans partners sons interviewed twice partners interviewed offspring total sons interviewed families also included partners mothers children statistical analysis used multi level modelling compute odds ratios confidence intervals controlling clustering effects within families parent ptsd diagnoses examined associations offspring trauma exposure ptsd psychiatric diagnoses ptsd increased risk ptsd disorder sons partner ptsd depression also risk factor sons ptsd alcohol disorder linked alcohol dependence sons ptsd controlling ptsd conclude ptsd father increases risk specifically ptsd sons
called advanced core new option tries remove tissue patients femoral head minimally invasive way use percutaneous bone graft substitute seventy two sixty patients mean follow months included study patients underwent physical examination preoperatively six weeks surgery two follow ups certain phases disease progression size lesion differentiated basis classification femoral head femoral heads cases analysis survival rates regard defect size revealed largest defects significantly higher rate femoral head collapse smaller defects clinical scores also depending defect size also disease stage current technique yet achieved significant improvement success rate core procedures concluded success depends especially defect size copyright john wiley sons ltd
although great deal progress made toward understanding role acid aba fruit many components aba signalling pathway remain elucidated gene homologous arabidopsis gene named isolated characterized cdna includes intact open reading frame encodes deduced protein amino acids putative conserved domains determined homology analysis transcriptional analysis showed levels mrna expression declined rapidly fruit development evidenced real time pcr semi quantitative reverse northern blotting analyses suggesting protein phosphatase encoded involved fruit negative regulator results tobacco virus induced gene silencing vector mediated overexpression suggested regulation mrna expression levels fruit promote inhibit respectively furthermore alteration expression differentially regulate transcripts set aba responsive related genes including chi taken together data provide new evidence important role aba regulating fruit processes type protein phosphatase serves negative regulator finally possible core mechanism underlying aba perception signalling transduction fruit discussed
purpose present study aimed investigate association hypertension physical functional capacities community dwelling older methods older female volunteers two groups hypertensive volunteers medical records reviewed underwent evaluations anthropometric data weight height body mass index physical functional results showed hypertensive older females presented higher values age weight body mass index resting diastolic blood pressure older females older females showed higher performance one leg stand test six minute walk test compared hypertensive older females age body mass index maximal walking speed performance time six minute walk test diagnosis diabetes mellitus type factors associated hypertension using chi square test however multivariate regression analysis indicated performance six minute walk test factor associated patients higher scores six minute walk test associated aerobic capacity show less odds clinical diagnosis hypertension however hypertension associated poor physical functional capacity
intrauterine devices long acting reversible contraceptives induce number immunological biochemical changes uterine environment affect endometrial cancer risk addressed relationship pooled analysis data collected epidemiology endometrial cancer consortium combined individual level data cohort case control studies total cases controls using multivariable logistic regression estimated pooled odds ratios pooled ors confidence intervals cis risk associated ever use type device ages first last use duration use time since last use stratified study adjusted confounders ever use inversely related risk pooled compared never use reduced risk observed pooled older age first use years pooled older age last use years pooled longer duration use years pooled recent use within year study entry pooled future studies needed assess respective roles detection biases biologic effects related foreign body responses bleeding increased clearance carcinogenic cells localized hormonal changes new associated endometrial cancer around world intrauterine device gaining popularity long term birth control strategy positioned embedded uterine iud affect endometrial tissue study builds previous work considering type device used addition factors duration use authors found women used iud particularly iud less risk endometrial cancer longer device used found cancer risk decreased
paper delayed eddy simulation applied study control effect wind induced effect static bridge deck isolated holes arranged lower surface test model direction based previous studies similar body proper distance chosen trigger amplify unstable secondary instability mode wake simulation results show arranged close wake best control effect reducing fluctuating aerodynamic forces due mean velocity modification isolated virtual aerodynamic shape modification generated act perturbation suppress results indicate trigger amplify mode instability hence lead dislocation vortex even completely suppress vortex addition control vortex shedding wide range elsevier ltd rights reserved
affective instability conceptualized fluctuations mood time related health psychopathology study examined role affective instability daily pain outcomes patients chronic pain age years females using end day diary baseline phase patients completed self reported questionnaires pain severity pain duration disability depression anxiety subsequent diary phase patients filled electronic end day diary consecutive days assessing daily levels pain severity disability cognitive complaints negative affect positive affect affective instability mean square successive differences daily mood separately positive affect takes account size affective changes consecutive days results indicated instability positively associated daily disability beyond effects daily pain severity furthermore instability moderated relationship daily pain severity daily disability relationship daily pain severity daily cognitive complaints positive affect instability however showed unrelated outcomes current findings extend previous results reveal putative role affective instability pain related outcomes yield important clinical implications indeed suggest targeting instability improving emotion regulation skills strategy diminish disability cognitive complaints patients chronic pain
context patient family dissatisfaction result satisfied physician patient interaction although physician feel worked hard provide information patient family new approaches visual analysis identify significant insights physicians personal clinical experiences providing palliative care end life care provide effective practical vehicle communicating patients families professional caregivers objectives elucidate palliative physicians core experiences patients death methods qualitative visual analysis conducted images created physicians completing one year palliative medicine images part larger personal reflections narratives database images text auditory projects prepared students completing training palliative care large provider participation personal reflections project required part training program goal blending clinical competencies lived experiences caring results two categories visual underlying images identified expressing relationship transitional dynamics life death nature conventional images representing anxiety pain dimensions suffering commonly associated death virtually absent conclusion propose communication positive even perceptions death likely result effective personal professional skills gained physicians clinical experiences american academy palliative medicine published elsevier inc rights reserved
acyl cholesterol converts intracellular free cholesterol cholesterol ester storage lipid droplets plays important role formation macrophage derived foam cells atherosclerotic lesions serotonin potent released activated platelets increases uptake oxidized low density lipoprotein ldl macrophages leading foam cell formation contributes development atherosclerotic plaque however yet known whether affects expression human monocyte macrophages molecular mechanism enhanced foam cell formation remains unclear examined effects expression differentiation cultured human monocytes macrophages expression protein receptor increased time dependent manner increased activity concentration dependent manner days primary monocyte culture immunoblotting analysis showed increased protein expression level two fold effect abolished completely receptor antagonist major metabolite protein beta protein kinase inhibitor family inhibitor mitogen activated protein kinase mapk kinase inhibitor northern blotting analysis indicated among four mrna transcripts levels transcripts selectively regulated similar fold results present study suggested play crucial role macrophage derived foam cell formation regulating expression via receptor protein mapk pathway contributing progression atherosclerotic plaque elsevier ireland ltd rights reserved
paper studies control coexisting impacting system via recently developed control law based linear augmentation special attention given two control issues framework engineering systems namely switching coexisting without altering systems main parameters avoidance induced chaotic responses effectiveness proposed control scheme confirmed numerically case periodically excited soft impact oscillator analysis shows path following techniques non smooth systems used order determine optimal control parameters terms energy expenditure due control signal transient behavior control error applied broad range engineering problems elsevier rights reserved
paper presents parametric study recently proposed photovoltaic solar power hybrid system based energy exergy analyses steady state physical model established hybrid system carry energy exergy analyses general shaped distribution concentrated solar energy flux density employed effects various parameters investigated including average optical concentration ratio outlet temperature solar thermal receiver coolant saturation vapor temperature results show generating efficiency power output hybrid system increase compared alone system indicates proposed hybrid system great potential increase utilization ratio solar energy increasing average optical concentration ratio decreasing outlet temperature solar thermal receiver result evident increases energy efficiency exergy efficiency hybrid system also shown energy exergy efficiencies organic rankine cycle subsystem nearly independent direct normal irradiance hybrid system always operated high efficiency despite change different moments days elsevier ltd rights reserved
paper study design user selection time allocation processing matrix multi carrier transmission employing shared user equipment side distributed antenna system proposed simultaneously utilizes licensed frequency bands frequency bands large available wave bands enable spatial gain single antenna improve energy efficiency throughput generation outdoor indoor communication resource allocation algorithm design formulated optimization problem maximization end end system energy efficiency bits matrix optimization problem converted equivalent scalar optimization problem multiple parallel channels solved asymptotically globally optimal iterative algorithm besides propose suboptimal algorithm finds locally optimal solution optimization problem simulation results illustrate proposed resource allocation algorithms achieve significant performance gain terms system energy efficiency spectral efficiency compared conventional baseline systems offering multiple parallel data streams single antenna
syndrome autoimmune mediated peripheral neuropathy unknown cause however quarter patients suffered recent bacterial viral infection axonal forms disease especially common patients proteomics good methodological approach discovery disease biomarkers recently proteomics studies neurodegenerative diseases focused analysis cerebrospinal fluid csf however serum represents attractive alternative csf easier sample potential biomarker discovery goal research identification serum biomarkers associated recovery address objective quantitative proteomics approach used characterize differences serum proteome patient healthy identical twin order variations due differences genetic background additional serum samples collected unrelated spinal cord injury sci patients similar medications proteomics results validated elisa using sera additional patients healthy individuals sci patients recovering acute phase disease results showed protein essential maintenance active zone structure constitutes potential serological correlate recovery results provided first evidence putative role suggesting candidate target developing serological marker disease recovery
purpose traumatic injury leading cause work disability receiving compensation post injury consistently found associated poorer return work study investigated whether relationship receiving compensation return work associated elevated symptoms psychological distress anxiety depression posttraumatic stress disorder perceived methods injured persons employed time injury recruited state trauma registry orthopaedic trauma outcomes registry participants completed hospital anxiety depression scale posttraumatic stress disorder checklist experience questionnaire pain work status months following traumatic injury results greater financial worry indicators actual perceived fault another perceived sustaining injury trauma severity days hospital intensive care discharge rehabilitation distress symptoms anxiety depression ptsd led twofold increase risk failing return work anxiety post traumatic stress perceived elevated following injury compared non injury perceived uniquely mediated association compensation return work adjusting age injury trauma severity length hospital admission intensive discharge location pain severity conclusions given perceived associated poor return work injury recommend greater attention given appropriately addressing psychological distress perceived injured workers facilitate transition return work
purpose maternal influences contribute origin allergic diseases mechanisms clear current literature prompted role epigenetics development allergic diseases sought investigate roles regulatory treg cells box dna methylation process maternal transmission allergic rhinitis susceptibility methods balb female mice mother sensitized intraperitoneal injection der day normal male mice day day female mice intranasal challenged der continuously normal controls given normal saline way postnatal day female mice offspring sacrificed detect histopathology nasal cytokines sera mother spleen offspring treg cells count mrna expressions dna methylation levels results compared normal controls neonatal offspring der stimulated female mice offspring showed elevation interleukin spleen treg cells count offspring decreased remarkably compared normal offspring though difference dna methylation level offspring normal control offspring obvious correlation analysis demonstrated significantly positive correlation dna methylation level mother offspring conclusions influence maternal neonatal offspring develop helper type dominant immune state closely associated treg cells dna methylation mechanism responsible maternal effect still need studies ensure
detecting accounts online social networks protects operators users various malicious activities detection mechanisms attempt classify user accounts real benign malicious analyzing either user level activities graph level structures mechanisms however robust attacks accounts operation patterns resembling real user behavior article show victims real accounts whose users accepted requests sent form distinct classification category useful designing robust detection mechanisms particular present robust scalable defense system leverages victim classification rank real accounts higher operators take actions low ranking accounts starts identifying potential victims user level activities using supervised machine learning graph assigning lower weights edges incident potential victims finally user accounts based landing probability short random walk starts known real account walk unlikely low weight edges steps land achieves desired ranking implemented using widely used open source distributed computing platforms scaled nearly linearly evaluated state art account detection using real world datasets large scale deployment largest spain million active users show significantly outperforms user ranking quality requirement employed victim classifier better random moreover deployment resulted order magnitude higher precision account detection compared elsevier ltd rights reserved
work study solution recently introduced measurement based approach design approach coefficients function design parameters obtained measurements solution coefficients analyzed experimental electrical circuits made voltage source resistors
theoretical analysis generation electrical streaming currents electrical power two phase flow rectangular capillary presented injection second non conducting fluid phase tends increase internal electrical resistance electrical generator thereby increasing power output viscosity injected fluid large resulting high shear rate low viscosity fluid wall generates large streaming current power generated enhanced however injected fluid viscosity low wall shear rate viscous fluid reduced streaming currents power generation small capillary effects ends increase pressure drop along capillary expected flow
mobile applications becoming popular prevalence mobile operating systems mobile internet many consume services provided underlying infrastructure platforms part application environmental contexts however application failures performance results due inadequate provisions environmental issues implementations mobile applications paper propose framework enable mobile applications consume services offered reliable context provider high probability run time report case study suite five real world mobile applications real faults real mobile phones involving users results case study show framework significantly improve reliability mobile applications respect failures due faults low energy
adolescents particularly prone peer influence since group membership modulates persons tendency take someone viewpoint decided investigate whether adolescents influenced presence peer taking another persons perspective group adolescents upper secondary schools italy observe scenes actor adolescent adult object still required judge spatial location object adolescent participants adopted actors viewpoint third person perspective frequently actor adolescent rather adult adolescent actor object thus adolescents seem particularly prone mentally simulate someone actions person peer findings suggest modulating motor simulation processes via social environmental factors influence adolescents perspective taking foundation professionals services adolescents published elsevier ltd rights reserved
mammals short photoperiod associated high depression anxiety like behaviours low levels brain serotonin precursor tryptophan brain levels regulated ratio large neutral amino acids circulation study elucidated whether diets various protein sources contain different affect depression anxiety like behaviours mice short day conditions control mice diet time spent central area open field test lower mice long day conditions indicating exposure induces anxiety like behaviour induced anxiety like behaviour diet given mice gluten diet transition time spent central area higher control mice alternatively mice ingested protein transition lower immobility forced swim test depression like behaviour compared control analysis revealed lower control compared control diet furthermore mice gluten protein diets transition exhibited high levels plasma conclusion ingestion specific proteins different times relative transition modulate anxiety depression like behaviours partially changes plasma
aberrant expression microrna mir contributes regulation normal cancer cell biology associated human malignancies however operate contradictory manner role mir remains fully elucidated aim present study investigate effects mir progression tumor cell proliferation examine molecular mechanism underlying level mir determined using reverse transcription quantitative polymerase chain reaction qpcr analysis matched tissues human cancer cell lines roles mir cell proliferation survival cell cycle analyzed using mir mir infected cells addition downstream target proteins wnt beta catenin signaling pathway evaluated using western blot analysis mir infected cells mir infected cells also treated exogenous beta catenin respectively following expression beta catenin measured using western blot analysis survival determined using bromide mtt assay results qpcr analysis showed expression level mir significantly higher tissues compared matched tissues observed cell lines cells infected mir levels mir significantly upregulated human cancer cells overexpression mir cells promoted cell growth treatment cells specific antisense microrna mir indicated durations reversed effects mir additionally treated cells showed phase arrest suggesting mir contributed regulation cell cycle addition results western blot analysis showed mir infected cells levels cyclin myc lymphoid enhancer binding factor significantly increased compared control infected cancer cells note infection mir affect levels glycogen synthase kinase beta cells whereas expression levels beta catenin cells cells significantly increased addition exogenous beta catenin effectively reversed efficiency mir specific detected using mtt assay data suggested critical role mir human via regulation wnt beta catenin signaling pathway demonstrated mir oncogene human
catalyzes conversion first reaction pathway biosynthesis nad even though activity described responsible ability increase nad levels human cells effectively far limited number studies human appeared extensive characterization recombinant human reported determined major kinetic parameters assayed influence different compounds enzymatic activity particular atp showed apparent dual stimulation inhibition effect low high substrates saturation respectively consistent negative model whereas inorganic phosphate found act activator among metabolites assayed including nucleotides intermediates carbohydrates metabolism showed inhibitory properties coa several acyl phosphate whereas phosphate pyruvate exerted effect furthermore light absence data performed homology modeling predict protein three dimensional structure molecular docking simulations identify residues involved recognition stabilization several ligands residues resulted universally conserved among study importance enzyme activity validated site directed mutagenesis elsevier masson sas rights reserved
objective aim study evaluate impact mindfulness based interventions psychological physical health outcomes adults overweight obese methods searched electronic databases randomized controlled trials prospective cohort studies met eligibility criteria comprehensive meta analysis software used compute effect size estimate results fifteen studies measuring post treatment outcomes mindfulness based interventions individuals identified average weight loss overall effects large improving eating behaviours medium depression anxiety eating attitudes small body mass index bmi outcomes therapeutic effects bmi anxiety eating attitudes eating behaviours remained significant examining results higher quality randomized control trials alone efficacy advantage studies exceeding median dose face face intervention studies utilizing acceptance commitment therapy approach provided significant effect improving bmi mindfulness approaches produced great variation small large effects across range psychological health eating related constructs finally limited longitudinal data suggested maintenance bmi eating attitudes gains follow detectable lower quality prospective cohort studies conclusions mindfulness based interventions physically beneficial adults overweight obese high quality research examining mechanisms action encouraged
homogeneous complete combustion internal combustion engines advantageous use porous foam exhaust gas engine cylinder heat recovery examined aim reducing engine emissions internal combustion engine porous core modeled using software solved differential equations thermal circuit engine engine thermal efficiency observed increase porous core applied raising compression ratio causes peak pressure thermal efficiency increase increasing compression ratio causes thermal efficiency output work increase respectively also used catalytic converter fine particles emissions hydrocarbons meanwhile heat recovered exhaust gases reduce fuel consumption reducing pollutant emissions internal combustion engine
androgen deprivation therapy mainstay treatment advanced prostate cancer treatment goal suppression plasma testosterone levels established decades evidence growing though suppression even lower levels add clinical benefit therefore undertook pooled retrospective analysis efficacy month sustained release formulations releasing hormone agonist suppress serum testosterone concentrations beyond current standards data male patients enrolled prospective studies using testosterone serum concentrations primary endpoint pooled patients aged years eligible either hormonal treatment undergone appropriate prior patients treated formulations months primary endpoints analysis serum testosterone concentrations treatment success rates overall per formulation based testosterone target threshold months treatment patients reached testosterone levels respectively month formulations success rates ranged median interquartile range serum testosterone values study end respectively large majority patients formulations suppressed serum testosterone concentrations even testosterone routinely monitored patients although studies clinical benefit low testosterone levels target concentrations still warranted
objective determine levels ankylosing spondylitis investigate relations disease activity materials methods patients male female age sex matched controls male female enrolled demographic data disease activity scores complete blood count erythrocyte sedimentation rate esr reactive protein crp levels recorded results mean ages patients controls years respectively inactive patients respectively positively correlated basdai esr crp levels correlated basdai negatively correlated esr levels conclusions significantly higher patients controls correlated basdai correlated
general influence childrens health health behavior however given dearth specific literature regarding knowledge level social cultural factors influencing hpv vaccination behaviors among american parent difficult develop effective evidence based public health hpv vaccination program therefore objectives study determine hpv vaccine among teenagers examine factors influencing hpv vaccine design descriptive cross sectional survey design combination network targeted sampling methods used mothers completed health survey face face interviews either english language girls vaccination rates boys awareness knowledge hpv among mothers low many believed english educated knowledge health logistic regression analysis showed girls significantly higher odds vaccination mothers possessed higher level english reading ability greater awareness knowledge hpv conclusionsthe strikingly low rates hpv vaccination among girls boys underscore need improve vaccination outreach education uptake findings used develop targeted public health hpv vaccination programs reduce cervical cancer disparities
use data acquisition system important process industry enables analog signal physical system converted digital signal processing computer vice versa however many available market today complex expensive paper presents development simple low cost open source microcontroller based system process automation control proposed system built around arduino microcontroller test experimental results developed system proved suitability application process monitoring control applications
background inflammatory bowel diseases ibd including crohns disease ulcerative colitis characterized chronic inflammation intestine reduce absorption nutrients vitamin calcium objective investigate bone alterations serum levels vitamin patients ibd method cross sectional study based review medical records patients private office brazil serum levels vitamin bone measured diagnosis ibd total patients included irritable bowel syndrome ibs comparison group results compared patients patients showed higher prevalence bone alterations osteoporosis osteopenia bone alterations occurred cases osteoporosis osteopenia vitamin levels among patients vitamin deficiency insufficiency sufficient cases deficiency insufficiency sufficient serum levels vitamin group ibs deficiency observed cases insufficiency significant difference groups conclusion ibd patients high prevalence bone changes especially serum levels vitamin recommended evaluated groups
research verified intergroup contexts strong tendency attribute secondary emotions uniquely human ingroup limiting attribution experiments shown common ingroup bias however yet known characteristics mitigate trend paper presents two studies first analyzes impact helping behavior attributions human traits two groups second studys objective determine members spanish ingroup outgroup less outgroup performs prosocial behavior towards another group determined decision task using names ingroup outgroup members priming results demonstrate describing group terms increases human profile experiment one reduces experiment two
presence higher order harmonics causes problems quality efficiency energy supply voltages sinusoidal inverters pulse width modulated pwm asynchronous motors drives widely used industry paper proposes artificial neural network identifies quality sine wave calculates efficiency electric drive system according index modulation sine wave voltage delivered electric motor along inverters modulated devices also shown effect efficiency operation harmonic losses
paper presents technique offline time synchronization data acquisition systems technique applied real time synchronization data acquisition systems impossible sufficiently accurate allows accurate synchronization based acquired dynamic response structure without requiring common response use trigger signal synchronization performed using results obtained system identification assumes linear dynamic behavior structure proportional damping structural modes demonstration laboratory experiment cantilever steel beam shows proposed methodology used accurate time synchronization resulting significant improvement accuracy identified mode shapes elsevier ltd rights reserved
contact dermatitis icd chronic relapsing skin disease severe lesions despite growing prevalence therapeutic treatments remain limited long term topical corticosteroid treatment induce skin atrophy increase water loss innovative dermal treatment essential reduce side effects corticosteroids topical res although effective icd challenging molecule due low solubility poor bioavailability objective work build res loaded solid lipid nanoparticles res skin targeting purpose res prepared using probe method utilizing res evaluated particle size efficiency transmission electron microscopy tem studies res incorporated gel investigated vivo skin deposition study human skin finally skin irritation study new zealand white rabbits assessed possible beneficial effects icd using balb mice showed mean size tem studies confirmed spherical particles nanometer range vivo study res loaded gel exhibited controlled drug release similarly vitro drug deposition studies showed potential skin targeting skin irritation gel confirmed competent suppression ear swelling reduction skin water content balb mouse model compared gel thus formulated res gel safe effective alternative conventional vehicles treatment icd
system measuring dielectric grains mhz sample presented several polar used calibrate verify permittivity measurements obtained signal flow graph model full two part parameter measurements lowest frequencies mhz phase measurements less accurate lumped parameter model used dielectric loss factor measurements system calibrated measurements air verified measurements standard error polar used verification dielectric constant dielectric loss factor although measurements taken static samples sample designed accommodate flowing grain dielectric properties measurements degrees taken four hard red winter wheat cultivars ranging moisture content bulk densities varying data agreed measurements reported literature
structural health monitoring key factor life cycle management infrastructures truly distributed fiber optic sensors able provide relevant information large structures bridges nuclear power plants nuclear waste disposal facilities sensing chain includes unit sensing cable made one optical fibers new instrument based optical frequency domain enables perform temperature strain measurements scale spatial resolution hundred meters level precision equal strain degrees several sensing cables designed different materials targeting last decades concrete aggressive environment ensure optimal transfer temperature strain concrete matrix optical fiber tests carried embedding various sensing cables plain concrete specimens representative scale reinforced concrete structural elements measurements performed instrument meanwhile mechanical imposed concrete element preliminary experiments promising since measurements performed distributed sensing system comparable values obtained conventional sensors used civil engineering strength materials modelling moreover distributed sensing system makes possible detect localize cracks appearing concrete mechanical loading
paper models left system finite interacting elements separate internal energy generic double spectral proposed formalism analytically allows derive entropy temperature heat capacity energy set particularly heat capacity found negative high energies analytical findings supported numerical results interestingly numerically heat capacity system seems decline increasing internal energy sets elsevier rights reserved
dynamic simulation model micro unit based ice internal combustion engine built new component model considers dynamic processes including start protection controls experiment study steady dynamic performances unit presented analyzed parameters dynamic model model validated experiment data steady dynamic processes improvement prediction accuracy model considering dynamic processes analyzed validation results show dynamic model predict characteristics unit start protection control processes cumulative prediction errors dynamic model decrease increase start stop interval considering dynamic processes eta total cumulative prediction errors decreased respectively start stop interval primary energy saving ratio emission reduction ratio increases increase start stop interval start stop interval unit paper longer energy consumption micro unit larger conventional system elsevier ltd rights reserved
rapid prototyping manufacture technology computer tomography image processing mechanical analyses adopted repair skull defect injury patient data exported digital imaging communications medicine format data processed mimics software eliminate noise gray level registration processing filtered data preserved bone data files analyzed processed put equipment equipment one type stereo apparatus laser light spot diameter models analyzed comply patients requirements stereo model mechanical properties shape patients bone titanium alloy plate matched anatomy reconstructed model accurate within
common cause community acquired pneumonia cap clinical presentation pneumonia varies widely genetic variability affecting host response also influence susceptibility several studies investigated association single nucleotide polymorphism snp genes risks cap however results inconsistent investigated association functional genes risks including ace total subjects cases controls using primer allele specific polymerase chain reaction pcr sanger sequencing gene gene interactions analyzed using dimensionality reduction cumulative genetic risk score approaches results showed snps ace significantly associated risks differences observed genotype frequencies groups combinations ace ace contribute genetic susceptibility chinese children
noted scientific fields processes paradigm change painful periods old theories longer fit available data placed new theories periods typically create debate ideological differences emerged old new theoretical approaches current paper argue period reached within field aggression research past half century social cognitive social learning paradigms aggression exemplified general aggression model retained dominance particularly areas media violence data support social cognitive approaches aggression never conclusive newer evidence increasingly suggests social cognitive theories aggression generally adequate explain aggressive phenomena discuss weaknesses problematic sometimes hidden assumptions reduce utility paradigm current evidence suggests social cognitive paradigm aggression approaches focus stress hold greater promise elsevier ltd rights reserved
background objectives mortality substance misuse constantly changing pattern notable rising trends certain regions country particular county new historically problem inclusion city high poverty rate high availability illicit drugs broader regional impact economic analysis substance misuse related death population facilitate understanding factors development maintenance addiction resulting mortality methods mortality population data obtained public sources subjects demographic information substance profile found death investigated regression trend analysis results across study period overwhelming majority subjects white adult males derivatives highest offending agent occurring deaths followed furthermore subjects found substances death significant trends found mortality rates county significantly higher rates drug mortality rest new study period conclusions scientific significance study highlights epidemic major player county also notes significant mortality contributions drugs setting use elicited time death imperative focus basic needs particularly housing outpatient long term programs rather inpatient rehabilitation especially population high poverty rate
bone turnover markers assist fracture risk prediction management monitoring osteoporosis patients without chronic kidney disease ckd use ckd mineral bone disorder limited many markers breakdown products excreted including commonly used standardized type terminal cross linking type collagen markers unaffected renal function bone specific alkaline phosphatase associated mortality fracture rate ckd subjects now available several automated used combination bone specific alkaline phosphatase bone formation marker correlated bone biopsy predicting bone disease resistant acid phosphatase resorption marker development automation high low bone turnover ckd patients associated increased fracture mortality risk bone biopsy gold standard differentiate bone disease limited availability cost appropriate use bone turnover markers vital decision anti agents monitor efficacy order avoid suppression bone turnover lead stress fractures efforts required develop markers unaffected renal function standardized cut values fracture vascular calcification end points
better understanding human metabolism relationship diseases important task human systems biology studies paper present high quality human metabolic network manually reconstructed integrating genome annotation information different databases metabolic reaction information literature network contains nearly metabolic reactions human specific metabolic pathways according functional relationships analysis functional connectivity metabolites network tie structure found previously structure analysis furthermore distribution disease related genes network suggests substrates subset tie structure flexibility parts
total antibiotic resistant isolated face patients dermatology staff controls resistant chosen detect gene detected strains however just strains also gene carried confers inducible resistance dna sequences pcr amplification products new mediated antibiotic resistance showed identity gene isolated southern blotting analysis specific probe shows two copies resistance gene integrated within chromosomal dna first report carried outside europe whilst gene associated strains data suggests genetic element carrying high affect efficacy treatment egypt elsevier ltd rights reserved
understanding biologically relevant structural functional behavior proteins inside living plant cells possible combination structural biology cell biology state art structural biology techniques typically applied molecules isolated native context although experimental conditions easily controlled dealing isolated purified protein serious vitro work mimic extremely complex intracellular environment protein exists functions therefore highly desirable investigate proteins natural habitat within live cells major cell nmr aims approach structure function relationship true vivo conditions following delivery labeled proteins cells physiological conditions multidisciplinary approach includes recombinant protein production confocal fluorescence microscopy nuclear magnetic resonance nmr spectroscopy different intracellular protein delivery strategies explore possibility develop cell nmr studies living plant cells provide comprehensive framework set cell nmr identified efficient intracellular introduction isotope labeled proteins major bottleneck based experiments intrinsically disordered proteins early response dehydration protein also established subcellular localization abiotic stress
aim paper contribute elaboration environmental stress hypothesis framework testing eight hypotheses addressing direct impact gross motor coordination problems elementary school selected physical behavioral psychosocial outcomes adolescence results based longitudinal sample participants recruited part population based representative survey health physical fitness physical activity childhood adolescence assessed twice within years ages years old ages years old response rate iii classified gross motor coordination problems gross motor coordination problems baseline motor tests measures weight height validated physical activity questionnaire strength difficulties questionnaire conducted data analyzed use binary logistic regressions results indicated elementary school children gross motor coordination problems show higher risk persistent gross motor coordination problems avoiding organized physical activities elevated body mass bonding sedentary peers emotional conduct problems adolescence comparison elementary school children without gross motor coordination problems however elementary school children gross motor coordination problems show significantly higher risk peer problems diminished prosocial behavior adolescence respectively comparison elementary school children without gross motor coordination problems study first provide population based longitudinal data ranging childhood adolescence context environmental stress hypothesis considered substantial methodological progress summary gross motor coordination problems represent serious issue healthy transition childhood adolescence respective early movement interventions
noise induced quantization digitally controlled systems modelled small amplitude chaotic behaviour described simple piecewise linear map micro chaos map chaotic nature certain micro chaos maps proved rigorously last years also pointed several coexist far desired state system control error influenced number sets local behaviour trajectories present paper focus exploration possible structures phase space controlled system estimate expected control error several methods
eosinophils multifunctional contribute initiation modulation inflammation role asthma parasitic infections long recognized growing evidence now reveals role eosinophils autoimmune diseases review summarize function eosinophils inflammatory bowel diseases autoimmune primary cirrhosis eosinophilic autoimmune diseases clinical studies targeted therapies experimental models contributed understanding regulation function eosinophils diseases examining role eosinophils autoimmune diseases different organs identify common pathogenic mechanisms include cytotoxic proteins induction antibody dependent cell mediated cytotoxicity release proteases degrading extracellular matrix immune modulation cytokines antigen presentation functions association eosinophilic diseases autoimmune diseases also examined showing possible increase autoimmune diseases patients eosinophilic syndrome non allergic asthma finally summarize key future research needs
conclusion elevated motion susceptibility disease likely consequence onset migraine per objectives pathologies system influence bilateral deficits lower benign paroxysmal little overall effect whereas migraine however less known condition many patients experience loss migraine symptoms methods authors conducted online survey posed diagnostic disease questions addressing frequency headaches visual display dizziness social life work impact dizziness motion susceptibility two groups diagnosed individuals hearing loss non individuals control group results group showed significantly elevated headache migraine increased higher scores increased higher controls development childhood although elevated compared controls lower migraine patients past data multivariate analysis revealed adulthood strongest predictors headache migraine
enhanced activity cutaneous arteries participates reduction skin blood flow induced cooling stimulation phenomenon characterized intense cooling induced cutaneous arteries common women period menopause thus investigated effect beta estradiol cooling induced reduction skin blood flow mouse vivo ovariectomized female mice treated eliminating sympathetic nerve tone artificially measured laser doppler cooling air temperature around foot degrees decreased temperature dependent manner suppressed specific antagonist administered followed constant infusion min just cooling stimulation cooling induced reduction facilitated dose dependent manner effect induced treatment similar effect induced intravenous application agonist protein coupled estrogen receptor also termed moreover effect abolished antagonist results suggest acute administration leads facilitation cooling induced alpha mediated reduction skin blood flow via activation non genomic estrogen receptor
transcription export complex complex facilitates localization actively genes nuclear periphery also functions contribute generation export competent interactions general mrna nuclear export factor complex based scaffold bind subdivided two modules one semi bind region residues similar two chains bind region residues similar complementary structural analyses using ray electron microscopy small angle ray scattering saccharomyces cerevisiae complex expressed using infected cells indicated like repeats region extend considerably towards terminus previously thought also indicate region region cerevisiae complex structurally independent although density visible accounted similar kda resolution reconstruction obtained region showed additional three putative extending towards terminus also seen resolution structure obtained ray summary statement describe expression purification structural characterization cerevisiae complex demonstrate like repeats extensive previously thought regions appear defined spatial orientation laboratory molecular biology published elsevier inc
since inception concept secondary psychopathy contrasted primary psychopathy grounds neuroticism affect instability anxiety nonetheless etiology primary psychopathy various possible expressions received ample attention secondary psychopathy largely neglected discussed cluster analytic studies paper seeks fill continuum secondary psychopathic individuals set apart exploring potential sources within group homogeneity heterogeneity secondary psychopathic individuals share number etiological antecedents attachment problems childhood maltreatment neurobiological dysfunctions vary different specific types maltreatment experienced childhood neglect abuse trauma abuse low high prefrontal activity thus creating heterogeneity observed group secondary psychopathic individuals situated continuum spans attentional cognitive far left side associated deficient prefrontal activity childhood neglect abuse ultimately expressions secondary psychopathy low attentional hypersensitivity cognitive rigidity far right side associated non optimally high levels activity childhood relational trauma abuse leading unstable expressions secondary psychopathy hostility neuroticism instability elsevier ltd rights reserved
objective study aimed investigate clinical characteristics risk factors obese patients methods obese patients without group obese patients group included study clinical data patients collected serum levels leptin measured elisa results body mass index bmi uric acid levels fasting insulin higher levels leptin significantly higher adjustment bmi gender male patients showed lower serum levels testosterone multiple logistic regression analysis demonstrated leptin independent risk factors addition low testosterone level independent risk factor male obese patients conclusions associated severe obese patients lower serum testosterone levels male patients leptin independent risk factors obese patients low testosterone valuable predictor male obese patients
purpose review purpose review give overview viral focus areas uncertainty diagnostics treatment outcome recent findings bacterial declining incidence recent years similar time period molecular diagnostics increasingly used developments viral becoming relatively important however still many unanswered questions despite improvements diagnostics many laboratories use molecular methods even used many cases still remain without proven viral aetiology identified also established treatments viral one potential treatment effective vitro simplex virus never subjected clinical trial summary viruses increasingly important cause era declining bacterial disease exact viral aetiology varies according age country molecular diagnostics improve rate pathogen detection also reduce unnecessary antibiotics use length hospitalization research required treatments viral impact terms longer term sequelae
widely accepted classic lesion cml traumatic lesion strongly associated abuse infants nevertheless various non traumatic origins continue suggested medical legal settings studies date systematically describe association traumatic injuries primary objective study examine association traumatic injuries large data set children evaluated physical abuse retrospectively planned secondary analysis data prospective observational study children months age underwent evaluation child abuse physician secondary analysis identified children parts per thousand months age identified cml determined number type additional injuries identified descriptive analysis used report frequency additional traumatic injuries among subjects identified cml least one additional non cml fracture thirty three traumatic brain injury nearly half children cutaneous injuries injuries found children abdominal thoracic injuries also found children children cml least one additional injury one four children three categories injury identified young children strongly associated traumatic injuries identification cml young child prompt thorough evaluation physical abuse
early diagnosis social isolation older adults prevent physical cognitive impairment diagnosis usually consists personal periodic application psychological assessment instruments unfortunately often tedious process therefore situation opens opportunities creating new ways diagnosis context ambient intelligence social networking sites suitable technologies automatic monitoring significant changes social interactions older adults however current instruments measure social isolation based subjective aspects since evaluate emotional social support consider objective aspects reason prediction model based objective isolation variables needed order measure social interactions computing mechanisms paper presents development prediction model social interaction activities registered smartphones sensory capabilities personal communications using online social network also radio frequency identification mechanisms proposed model benefit institutions interested developing technological solutions detect early stages social isolation improve quality life older adults
transcriptional variant phosphatase distal mouse chromosome expressed gene mouse study examined spatiotemporal patterns gene mouse development northern blotting analysis revealed one transcript detected brain signals observed brain whole mount situ hybridization embryonic day results quantitative real time pcr qrt pcr showed expression increased gradually reached highest decreased brain development gene strongly expressed cerebral cortex olfactory external layer cerebellum ventricular zone embryonic development whereas expression increased olfactory cerebellum birth using situ hybridization results also demonstrated expression gene mainly located olfactory hippocampus postnatal day adulthood results suggest specifically expressed mouse brain function development mouse brain
introduction studies biomaterials involve assays aimed assess interactions cells surface however morphology biomaterials heterogeneous results among different biomaterials classic plastic plates light decided create means computer aided design cad technology standardized sample model equal shape sizes able fit classic shape wells tissue culture plate tcp methods design sample consists hole top order allow injected cells without able slip sides sample bottom tcp wells cad project made using software pro engineer sample totally fill wells tcp dental pulp stem cells used assess ability different sample support promote cell proliferation results twelve titanium gold oxide customized samples designed means software cam file created pro engineer software proliferation rate tested scaffolds showed similar control group customized shape conclusion think method useful test different types scaffolds greater accuracy measurements desirable order verify cell behavior scaffolds innovative method improve standardization process evaluation cell behavior different biomaterials open way reliable tests functionalized drugs growth factors applied future regenerative medicine
anchored glycoprotein negatively regulates tgf beta signaling originally identified hematopoietic tumors however significance hematopoietic malignancies remains unclear study association diffuse large cell lymphoma prognosis eighty four specimens analyzed expression cases classified low high expression groups respectively expression associated overall survival using kaplan meier analysis log rank tests however significant association observed high expression low year survival moreover combination revised international prognostic index poor high associated poorer prognosis compared poor alone assessed tgf beta signaling depleted cells human lymphoblastic leukemia lymphoma cell line found prolonged phosphorylation compared control cells tgf beta stimulation suggesting attenuates tgf beta signaling human cell tumors results suggest putative biomarker identifying high risk group among patients
autoimmune diseases associated pathological pain development autoimmune diseases pathological pain include complex regional pain syndrome rheumatoid arthritis syndrome name present review explores research linking immune system development pathological pain autoimmune diseases pathological pain linked cell activation release cytokines activated microglia dorsal spinal cord new research role autoantibodies autoimmunity generated insights potential mechanisms pain associated autoimmune disease autoantibodies act various mechanisms autoimmune disorders include alteration neuronal excitability via specific antigens voltage gated potassium channel complexes mediating bone destruction rheumatoid arthritis although research done understand better role autoantibodies autoimmune disease related pain promising area research new analgesic therapeutic targets wiley periodicals inc
background obesity caused imbalance energy intake eating energy expenditure severe obesity prevalent women men worldwide obesity pathophysiology resultant obesity related disease risks differ women men underlying mechanisms largely unknown pre clinical clinical research indicate ovarian hormones play major role objective rationale systematically reviewed clinical pre clinical literature effects ovarian hormones physiology adipose tissue regulation mass energy intake search methods articles english indexed pubmed january searched using keywords related reproductive hormones weight regulation iii central nervous system sought identify emerging research foci clinical translational potential rather provide comprehensive review outcomes find estrogens play leading role causes consequences female obesity respect adiposity estrogens genes increase subcutaneous mass decrease central mass reproductive age women leads protective cardiometabolic effects loss estrogens menopause independent aging increases total mass decreases lean body mass little net effect body weight menopause also partially womens protective distribution effects estrogen treatment respect eating increasing estrogen levels progressively decrease eating follicular peri phases menstrual cycle progestin levels associated eating phase appear causal relationship increase binge eating eating stimulated negative emotional states phase pre clinical research indicates one mechanism pre decrease eating central action estrogens increase potency gastrointestinal hormone another mechanism involves decrease preference sweet foods follicular phase genetic defects brain stimulating hormone receptor receptor signaling lead syndrome obesity particularly pronounced women female animals syndrome appears around puberty mice genetic deletions suggesting role ovarian hormones emerging functional brain imaging data indicates fluctuations ovarian hormones affect eating influencing striatal dopaminergic processing lateral prefrontal cortex processing cognitive inhibitory controls eating dearth research neuroendocrine control eating menopause also comparatively little research effects ovarian hormones although changes ovarian hormone levels menstrual cycle affect resting wider implications markedly greater obesity burden women makes understanding diverse effects ovarian hormones eating body adiposity urgent research challenges variety research modalities used investigate effects women mechanisms reviewed accessible animal models therefore human translational research roles ovarian hormones womens obesity causes intensified gain mechanistic insights ultimately translated novel anti obesity therapies thereby improve womens health
arid semi arid regions quite often encounter granular soils high hydraulic conductivity loss irrigation water occurs due evaporation excess water resulting irrigation green eastern province saudi arabia found ground flow towards uncontrolled directions sand clay reinforced geotextile materials designed act smart barrier used harvest excess irrigation water engineering properties hydraulic conductivity sand clay investigated conditions yielding optimum output introduced based outcome laboratory test results carried mixtures clay material fine sand study presents framework landscape designers benefit idea select appropriate proportions suit intended collected water examined used irrigation
individuals obesity western societies often face weight related social exclusion recurrent exposure prejudice negative social feedback alters ones behavior future social interactions study aimed investigate autonomic nervous system affective responses social interactions individuals obesity women men without obesity participated episodes social inclusion social exclusion using virtual ball game experiment heart rate measured parasympathetic activity overall high frequency power event related cardiac slowing analyzed results show novel social interactions women obesity relative groups exhibited strongest increase parasympathetic activity furthermore parasympathetic activity related negative body image individuals obesity lean individuals additionally women obesity reported stronger decrease mood social exclusion participants results demonstrate influences objective subjective bodily characteristics parasympathetic regulation social interactions particular show behavioral physiological alterations social interactions women obesity
since xml benefit greatly database support specifically relational database systems study methodology modeling fuzzy spatiotemporal data xml transforming fuzzy spatiotemporal data xml relational databases accomplish devise fuzzy spatiotemporal data model xml capture semantics fuzzy spatiotemporal features allow better platform independent sharing fuzzy spatiotemporal data stored relational format propose temporal edge approach transform fuzzy spatiotemporal xml data relational databases unique feature approach schema information required transformation fuzzy spatiotemporal data moreover temporal spatial fuzzy features fuzzy spatiotemporal data xml documents taken consideration finally experimental results demonstrate performance advantages approach approach transformation provide significant consolidation interoperability fuzzy spatiotemporal data xml relational databases
growing interest use human whole saliva diagnostics disease monitoring alternative blood samples contrast blood whole saliva non sterile body fluid proper hand storage required preserve integrity potential biomarkers investigated salivary degradation using variety approaches determined inhibition protease activities monitoring endogenous proteome addition stability highly protease susceptible proteins assessed experimental variables included protease inhibitors salivary incubation temperatures sample heating containing pancreatic inhibitor prevent degradation whole saliva among treatments evaluated short term storage collected samples ice effective without interfering chemistry proteome conclusion whole saliva contains unique mixture enzymes evidenced resilience protease inhibition analytical evidence protein stability needed ensure validity salivary biomarker study outcomes analysis data presented provide help guidance use saliva samples diagnostic purposes
known comparative effectiveness safety non vitamin antagonist oral anticoagulants compared warfarin chinese atrial fibrillation patients aim compare ischemic stroke risk reduction incidence intracranial hemorrhage warfarin relation quality anticoagulation control reflected time therapeutic range real world cohort chinese patients rather warfarin preferred chinese patients patients studied years female patients warfarin patients patients mean follow months ischemic annual incidence year incidence ischemic stroke highest patients warfarin year followed year warfarin year whereas patients lowest incidence ischemic stroke year incidence lowest patients year compared year warfarin year year patients daily similar ischemic stroke risk year risk year compared conclusions chinese patients benefits warfarin therapy stroke prevention reduction depend treatments compared daily associated lowest ischemic stroke rates
work compares fundamental thermodynamic underpinnings working fluid properties heat release profile various combustion strategies engine measurements approach employs model separately tracks impacts efficiency due differences rate heat addition volume change mass addition molecular weight change given combination working fluid heat release profile engine geometry comparative analysis measured modeled efficiencies illustrates fundamental sources efficiency reductions opportunities inherent various combustion regimes engine operating regimes chosen analysis include spark combustion lean compression combustion including homogeneous charge compression ignition spark assisted homogeneous charge compression ignition conventional diesel combustion within combustion regime effects engine load combustion duration combustion compression ratio charge dilution explored model findings illustrate even absence losses heat transfer incomplete combustion maximum possible thermal efficiency inherent operating strategy varies significant degree additionally experimentally measured losses observed unique within given operating strategy findings highlight fact create future directions internal combustion engine technologies important compare absolute real world efficiency given combustion strategy also examine measured efficiency context possible working fluid boundary conditions prescribed strategy
given septic curve distinct ordered sequence control points determine whether curve via exact symbolic computation theory problem motivated study necessary sufficient condition planar septic curve possess based definition curve complex representation planar curve develop geometric conditions terms leg lengths angles control separated guarantee property relation compatibility solutions respect complex coefficients equations geometric constraints analyzed moreover septic curves extended construct shaped transition curves elsevier rights reserved
mindfulness based strategies show promise targeting construct impulsivity associated variables among problematic alcohol users study examined moderating role intervention mindfulness relaxation control trait impulsivity three outcomes examined post intervention negative affect positive affect urge drink among college students levels risk drinking moderation analyses revealed relationship baseline impulsivity primary outcomes significantly differed participants underwent mindfulness versus relaxation interventions notably simple slope analyses revealed negative urgency positively associated urge drink following mindfulness intervention among participants underwent relaxation intervention analysis simple slopes revealed negative urgency negatively associated urge drink positive urgency positively associated positive affect following relaxation intervention findings suggest level low high subscale impulsivity matter regard participant respond mindfulness versus relaxation intervention elsevier ireland ltd rights reserved
work macroscopic non linear constitutive model accounting damage strain unilateral behavior proposed plain woven sic composite set scalar damage variables new thermodynamic potential expression introduced framework continuum damage mechanics deduced constitutive equations materials progressive damage behavior compression loading described continuous function different rates compression loadings also considered damage evolution laws coupling effect among damage modes effect compression stress development shear damage different plane stress states taken account besides general plasticity theory applied describing evolution strain tension shear stress state failure criterion adopted strength analysis additionally material model implemented user defined material linked finite element software performance demonstrated several numerical examples production hosting elsevier ltd behalf
todays internet makes hosts individual networks inherently insecure permanent addresses turn permanent attack targets paper describes internet protocol change data plane internet prevents identities preserving current internet privacy paradigm gives recipients full control communicate long achieves features without requiring global signaling protocols allows coexistence introduction current internet motivate approach present architectural design evaluate trace driven synthetic simulations prototype testing
recently embedded systems become popular rising demand portable low power devices common task devices object tracking essential part various applications now object tracking video sequences remains challenging problem visual properties objects surrounding environments among common approaches particle filter proven effective dealing difficulties object tracking research develop particle filter based object tracking method using color distributions video frames features deploy embedded system particle filter high complexity algorithm utilize computing power embedded systems implementing parallel version algorithm experimental results show parallelization enhance performance particle filter deployed embedded systems
objective best material choice following remains subject discussion complication rates tend high computer assisted dimensional modelling recently introduced cranial reconstruction aim study evaluate patient surgery related characteristics risk factors predispose patients complications material methods retrospective study included total cranial implants patients performed two reference centers netherlands complications registered patient surgery related data carefully analysed results overall complication rate complications included infection postoperative cerebrospinal fluid leak wound related problems postoperative infections required removal implant nonetheless removed implants successfully used sterilization conclusion although overall complication rates remain high outcomes satisfactory results compare recent literature reports cranial reconstruction european association facial surgery published elsevier ltd rights reserved
order reduce security risk commercial aircraft allowed take certain items carry reason human operators trained detect items using manually controlled screening process paper use automated method based multiple ray views proposed certain regular objects highly defined shapes sizes method consists two steps analysis obtain possible view sequence multiple view analysis objects interest using matching views search matching candidates efficiently performed using look table computed offline order illustrate effectiveness proposed method experimental results regular objects clips springs blades pencil cases shown achieving high precision recall objects believe possible design automated aid target detection task using proposed algorithm
overview wind tunnel activities methodologies developed last years support design long span suspension bridges proposed important aspects wind bridge interaction investigated considering aerodynamic phenomena affecting different parts bridge mainly deck towers experimental activities results proposed framework approach numerical experimental methodologies represents common practice defining full scale aeroelastic behavior bridge starting scaled reproduction wind bridge interaction static dynamic wind loads aeroelastic stability vortex induced vibrations investigated elsevier ltd rights reserved
study examines main moderating effects childhood abuse neglect severity income family social support presence postpartum depressive symptoms participants included postpartum mothers endorsed history childhood maltreatment enrolled longitudinal study mother child outcomes participants completed questionnaires assess severity associated societal maternal characteristics depressive symptom severity results confirm previously identified links severity hierarchical linear regression analyses indicate interaction household income interpersonal support family attenuates relationship severity final model accounted variance scores large effect size study first demonstrate income social support resilience postpartum psychopathology childhood trauma women social support appeared protect mothers study income conferred protective effect accompanied family support clinicians implies need focus improving family relationships especially risk mothers
nowadays image processing machine vision fields become important research topics due numerous applications almost every field science performance fields critically dependent quality input images imaging devices optical used capture images particular scene due limited depth field optical objects different distances focal point captured different details thus important details scene lost regions multi focus image fusion effective technique cope problem main challenge multi focus fusion selection appropriate focus measure paper propose novel focus measure based surface area regions intersection points input source images potential measure distinguish focused regions ones proved fusion algorithm intersection points input images calculated input images segmented using intersection points surface area segment considered measure determine focused regions using measure obtain initial selection map fusion refined morphological modifications demonstrate performance proposed method compare results several competing methods results show effectiveness proposed method elsevier rights reserved
increasing rates cancer patients undergoing radiation therapy treatment cause patients significant amounts anxiety distress attributed diagnosis disease lack knowledge radiation therapy expectations management side effects lack knowledge supportive care patients families providing patients effective educational tools meet informational needs cancer patients undergoing radiation therapy patients allow participate treatment decision making healthcare discussion paper evaluate several studies psychological impact cancer patients undergoing radiation therapy video material effectively meet informational educational needs patient population group
conducted comprehensive review literature establish evidence base using visual activity schedules vas individuals intellectual disability literature published evaluated quality using criteria developed total studies included acceptable findings suggest vas evidence based practice teaching variety daily living navigation vocational academic skills adolescents adults intellectual disability results also show increases independence task behaviors conclude article discussing limitations recommendations future research
paper present oriented system equation based line error correction scheme recursive digital signal processing target digital signal processing linear time invariant algorithm includes constant coefficient delays difficulties algorithm level fault tolerance algorithm without structural regularity include error distribution problem right timing error correction escape error distribution problem multiple fan nodes algorithm specified nodes error corrections performed oriented graph oriented system equation introduced formulate line correction schemes based strategy oriented graph treated collection computation sub blocks applying code independently sub block trivial line error correction scheme results appropriate selection error identification process sub block level one advantages method reduction redundant operations performed merging computation sub blocks hand system important issue method since line error correction mechanism induces additional data dependencies paper condition modifications scheme also discussed
background objectivethe copd assessment test cat reported potential utility measuring health status idiopathic pulmonary fibrosis ipf although cat developed assessment copd patients fully evaluated exclusively ipf study designed evaluate validity cat ipf methodsthe clinical data consecutive subjects newly diagnosed ipf completed pulmonary function tests partial pressure oxygen arterial blood rest min walk test cat respiratory questionnaire modified medical research council grade hospital anxiety depression scale analysed assessed validity cat comparison resultsthe present subjects showed mild moderate restrictive impairment mean cat score total respectively concurrent validity cat score comparison total score significant internal consistency cronbachs repeatability correlation coefficient cat also significant single regression analysis showed cat significant construct validity multiple regression analysis rest minimum anxiety independent predictors cat conclusionsthe cat valid health status measurement ipf patients multiple regression analysis showed cat significantly correlated severity impairment anxiety validity copd assessment test cat evaluated exclusively idiopathic pulmonary fibrosis ipf patients comparison respiratory questionnaire cat significant correlation independently predicted severity impairment anxiety
often reported premature failures expansion joints long span steel bridges call better understanding performance service conditions paper presents long term monitoring analysis displacements expansion joints emphasis influence viscous installed mitigate seismic responses bridges data three long span steel bridges bridge suspension bridge compared decomposition displacement signals various frequency bands reveals temperature induced movements contribute small portion total cumulative displacements small rapid movements caused vehicle wind loads cumulative displacements long span steel bridges far exceed caused temperature changes according monitoring data existence viscous reduce vehicle wind induced displacements significant influence temperature induced movements finite element analyses conducted validate influence viscous displacements expansion joints american society civil engineers
present work aimed develop novel composite material made activated bone powder starting material reducing chemical oxygen demand cod ammonia nitrogen palm oil effluent optimization reduction efficiency investigated using response surface methodology six independent variables used optimization experiments include speed contact time particle size dilution factor adsorbent dosage chemical functional groups determined using fourier transform irradiation ftir elemental composition detected using sem thermal decomposition investigated using thermo analysis tga order determine effects temperature adsorbent results revealed optimal reduction cod raw observed rpm within particle size dilution factor adsorbent dosage observed predicted reduction respectively cod main functional groups adsorbent sem analysis revealed composite smooth surface high contents carbon activated stable temperature profile significant weight loss conclusion composite investigated characteristics high potential remediation cod raw elsevier ltd rights reserved
extensive literature exists regarding potential effect sleep loss human performance recent regulatory changes now limit duty hours resident physicians recent studies reviews emphasize effects sleepiness medical errors commission lesser extent review focuses emerging literature effects sleep loss personal social professional growth development residents early literature sleep loss resident performance literature largely observational level sufficient evidence indicate sleep loss affect post graduate career life skills multidimensional approach needed counter adverse outcomes sleep loss fatigue consist education healthy sleep habits family outreach personal strategies reversal bias sleepiness disclosed multi dimensional approach include resident physicians also program attending physicians institutions elsevier ltd rights reserved
increasing concern long term effects sub head accelerations sport research applies two technologies initially developed team based sports understand characteristics head acceleration results indicate pediatric participants regularly achieved speeds head accelerations rare occur generally low magnitude risk make authors published elsevier ltd selection peer review responsibility school aerospace mechanical manufacturing engineering university
polymeric drag partially polyacrylamide important chemical additives hydraulic fluids significantly decrease frictional pressure drop resulting increase injection rate delivered point incorporation sodium acid moieties polyacrylamide improve performance fluids addressing compatibility issues related use sensitivity water salinity study three types poly pure investigated respect polymer induced drag reduction mechanical polymer degradation turbulent pipe flow pressure driven pipe flow facility test section comprised horizontal circular cross section pipe facility modified order allow long time length experiments automatically polymer solution closed loop test section presence groups backbone found increase ability reduce frictional drag vulnerability mechanical degradation remains unaffected drag reduction solutions described modified version correlation extended include effect reynolds number polymer mechanical degradation found proceed friction almost ineffective reducing drag phenomenon contrast common correlation polymer degradation predicts existence asymptotic finite limit reduced drag reduction authors published elsevier ltd
capacity reflect upon ones knowledge key trait cognitive repertoire developed childhood direct comparison metacognitive ability children years old adults using single perceptual task made results showed years old children level metacognitive access similar adults signal detection theory model applied order distinguish metacognitive ability propensity towards risk taking two factors far studies children presented suboptimal tendency towards risky decisions natural predisposition partially mitigated imposing conservative normative strategy elsevier inc rights reserved
paper propose simple method perform extraction moving camera cameras now available quite time popularity primarily due low cost ease availability although field extraction background explored computer vision researchers since long time depth based relatively new extensively addressed yet current methods make heavy use geometric reconstruction making solutions quite restrictive paper make novel use rgb data rgb frame extract corner features fast represent features histogram oriented gradients descriptor train non linear svm descriptors test phase make used fact object distinct depth ordering respect rest scene use positively classified fast features test frame initiate region growing obtain accurate segmentation object just data demonstrate proposed method synthetic datasets demonstrate encouraging quantitative qualitative results
background child abuse neglect risk factor development psychiatric disorders untreated disorders sustain adulthood objectives study compares rates psychiatric disorders mental health care utilization victims methods three regions germany children adolescents aged non abusive caregiver assessed childs history mental health mental health care utilization via semi structured interviews results approximately two thirds participants present state lifetime suffered psychiatric disorder icd posttraumatic stress disorder conduct disorders attention hyperactivity disorders frequently diagnosed merely using mental health care time assessment conclusions provision mental health care victims insufficient improve access appropriate services vulnerable cooperation psychiatrists child welfare system essential implementation dissemination evidence based diagnostic methods treatments advanced
article deals place electronic kits didactic system science technical subjects briefly summarizes measurements support computer kit laboratory measurement demonstration electrical circuits within general electro technical kits among didactic material resources term didactic tool range wide rich content default term issue educational resources important didactic categories
water borne diseases estimated cause two million deaths four billion cases diarrhea annually water borne pathogenic organisms include bacteria viruses heavy metal contamination water also potential threat human health study aimed detect contamination potable water bacterial pathogens heavy metals middle delta egypt therefore study conducted water samples different throughout year water samples collected source plant tap water four seasons toxicological evaluation carried samples evaluation done detect contamination conventional diagnostic staining techniques immunofluorescence assay flow cytometry study identified contaminants water showed flow cytometry positive results conventional staining also study identified bacterial fecal contamination source water heavy metal pollution source water since integration flow cytometry facilitate detection water samples strongly recommend use routine detection pathogenic finally ongoing evaluation drinking water needed formulation implementation integrated plan limit contamination pathogens heavy metals production hosting elsevier behalf university
satellite radio posed new question canadian policy makers take advantage radio service ensuring cultural identity lost within channel american comparing initial licensing satellite radio canada services post license renewal highlights shift spatial understanding satellite radio determined satellites footprint call cultural various mobile devices services enable one maintain connection cultural content alongside shifting spatial considerations satellite radio canadian content increasingly brand fragmented taste preferences individual mobile listening practices
security primary requirement era threats rising high degree penetrating system need security system analyze provide valuable information organization provides technology adds layer network security goal attacker real systems gain valuable information comparison intrusion detection technologies far better ability detect new attacks improve security network using existing intelligence security technologies designed get compromised new threats attackers attack analyze behavior attractive alternative acts trap detect network security
background efforts aimed health care reform continued advances information technologies prompted interest among providers researchers patient web patient web protected online websites offer patients hour access personal health information anywhere internet connection methods article based upon searches pubmed reviews important developments web primary secondary disease prevention including patient web electronic medical records disease specific health disparities health related community web results although findings uniformly positive several studies effectiveness health care system patient chronic disease management shown promising results regard patient outcomes patient web also shown promising results increasing adherence screening recommendations racial ethnic minorities younger persons patients less educated lower health literacy found less likely use patient conclusion additional studies needed utility effectiveness different elements web different patient populations include additional diseases health topics smoking cessation weight management
background various studies shown non diseases especially diabetes hypertension prevalent among older women living south african urban areas placing heavy burden healthcare system study aimed understand health seeking behaviour healthcare practices prevalence traditional herbal medicine use among older women self reporting prospective urban rural epidemiology study pure method homogenous sampling pure participants used recruit women years older descriptive statistics used examine number reported study sample health seeking behaviour practices use logistic regression also employed investigate possible associations reported conditions use medical results within study sample self reported self reported one two usually visited public clinics relied doctors nurses health information mostly used conventional medicine manage high blood pressure indicated using reported practicing medical participants dental problems headaches heart burn severe likely use anxiety allergies increased likelihood medical five times respectively conclusion self reported morbidities prevalent among participants study study participants utilized state owned clinics hospitals management chronic conditions use common however among used medical prevalent family history common reason use many utilizing treatment health condition older black women anxiety allergies likely medical
shape optimization stator rotor important electrical motor design among many motor design parameters stator tooth width determinants back load torque study proposed equivalent magnetic circuit motor stator efficient stator tooth width shape optimization using proposed equivalent magnetic circuit found optimal tooth width minimal magnetic resistance verify load torque truly maximized optimal tooth width indicated proposed method performed finite element analysis fea calculate load torque different tooth study confirmed reliability usability proposed equivalent magnetic circuit
isolate identify dna binding protein affinity mobile chromosomal repeat element bacillus group bacteria element immobilized coated magnetic beads used pull kda dna binding protein whole cell protein extract protein identified product orf encoded related autonomously replicating linear genetic element carried strain dna binding specific northern blotting orf transcribed orf also certain instances orf transcriptional located orf orf orf encodes dna binding protein orf transcribed upstream gene orf subset transcripts also downstream gene orf alternative transcription termination group contains bacterial species medical economic importance encoded proteins bacteria suggested potential therapeutic agents understanding biology related genetic elements functional characterization genes high relevance
work model simulate response shape memory alloy wires springs subjected torsional loading constructed combining thermodynamics principles along models following gibbs potential based formulation employed separate response shape memory alloys response part modeled discrete approach rather beginning full three dimensional model solving non homogeneous shear stresses across specimen cross section strength materials approach directly model torsional response using experimentally measurable quantities torque angle developed model results verified experiments performed shape memory alloy springs three different temperatures model also used predict response shape memory alloy wires different temperatures using experimental results one temperature case respectively torsional response three different wire diameters predicted using experimental data one diameter case published elsevier ltd
local material behaviour cast metal injection parts highly related geometrical design part large number process parameters order use structural optimization methods find geometry gives best possible performance geometry effect production process local material behaviour thus considered work multidisciplinary methodology consider local microstructure based material behaviour optimizations design engineering structures presented adopting knowledge based industrial product perspective combined previously presented simulation strategy microstructure based material behaviour finite element analyses fea methodology integrates computer aided design cad casting injection simulations fea design automation multi objective optimization scheme novel structural optimization method cast metal injection polymeric parts different concepts modules methodology described implementation prototype software outlined application relevance methodology discussed elsevier ltd rights reserved
objective copper intrauterine contraceptive effective method emergency contraception yet objective evaluate pilot project integrating copper care study design single group evaluation study nine geographically diverse reproductive health centers implemented month pilot interventions interventions included staff education inclusion patient counseling sites developed patient education materials health center staff completed manual monthly tracking forms number patients receiving oral levonorgestrel ulipristal acetate copper sites also tracked reported number patients returning removal month pilot period subsequent months main study outcomes included number insertions proportion day insertions proportion patients receiving type pilot period secondary outcome number patients returned removal months results insertions pilot period seventy seven percent day insertions returned insertion within days unprotected intercourse percentage patients choosing varied site overall months patients returned removal conclusions women interested copper therefore women offered option results suggest large majority continued use ongoing contraception implications copper viable option women need women offered effective option elsevier inc rights reserved
seek infinite sequence exact solutions dimensional equation paper utilize expansion method give nonlinear superposition formula backlund transformation solutions equation obtain equation infinite sequence exact solutions help symbolic computation system new infinite sequence exact solutions obtained
considering loaded empty moving tie robots moving among loading station machines station flexible robotic manufacturing cell scheduling problem multiple robots studied improved discrete particle swarm optimisation genetic operator random heuristic method created minimise addition multi robot scheduling strategy proposed minimise displacement operation transportation tasks positions critical operations structure established enhance capacity algorithm local search detailed algorithm design description report results computational study provides evidence proposed optimisation based approach delivers high quality solutions known algorithms
obesity growing public health problem united states particularly middle aged older adults although key factors leading population increase body weight still investigation evidence certain behavioral interventions mitigate negative cognitive brain neurocognitive health consequences obesity two primary behaviors often targeted weight loss caloric intake physical activity behaviors independent overlapping synergistic effects neurocognitive health date obesity often described independently behavioral interventions regards neurocognitive outcomes yet conceptual mechanistic overlap constructs review summarizes evidence linking obesity modifiable behaviors physical activity diet brain morphology gray white matter volume integrity brain function functional activation connectivity cognitive function across adult lifespan particular review evidence bearing following question associations obesity brain health aging adults modifiable behavioral interventions
ability accumulate light absorbance allowed early land plants resist irradiation made survival land possible largely consumed synthesized human present plants microorganisms number described phenolic compounds increasing due evolution new genes mutations response adaptation environmental changes wide range biological studies revealed antioxidant properties towards human pathologies cancer health benefits however depend amount ingested bioavailability many factors great influence bioavailability climate agricultural practices industrial processes host microbiota considered act metabolic organ important role human metabolism anticancer effect relies chemical structure concentration type cancer biological activity extensively studied preclinical assays overcome cancer resistance modulating cancer cells multiple drug resistance overexpression phenotype solid tumours hematological exert important role apoptosis induction cell growth inhibition cell cycle arrest oxidative stress cell migration differentiation combination flavonoids chemotherapy seems interesting approach cancer treatment addition points related bioavailability delivery needs elucidated order improve biological effects vivo
multi context systems introduced promising way decentralized heterogeneous knowledge contexts paper propose preferential multi context systems provide framework incorporating preference contexts contexts divided different according preference information flows context contexts stratum less preferred given positive integer first preferred able fully capture information exchange contexts thus contexts form new called section original generalize equilibrium semantics equilibrium represents belief state acceptable least section given also investigate inconsistency analysis related computational complexity issues elsevier inc rights reserved
electrochemical storage systems increasingly employed stationary automotive applications lithium ion technology nowadays shows best features future development prospects nevertheless lithium ion lot need know deep behaviour relation final applications among used lithium technologies selected two different lithium technologies lithium iron phosphate lithium polymers tested compared indeed several electrical vehicles developers electrical network operators choosing specific safety relatively low cost flexibility creating customized battery pack paper reports results several tests carried order investigate features battery technology stationary automotive applications particular capacity reduction effect cell efficiency analysed furthermore tests showed different time effect dynamic behaviour cells subjected different load profiles compliant iec international commission tests procedures final analysis carried comparing main performance indicators capacity energetic efficiency working temperatures etc elsevier ltd rights reserved
several models studies related tensile strength materials proposed literature size length component taken important factor studying specimens failure behaviour important model developed basis cumulative damage approach three parameter extension fatigue model incorporates size specimen additional variable model strong commonly used model stands better traditional models incorporate size effect paper considers two cumulative damage models compatibility real dataset compares recent finally recommends model appears appropriate one throughout study bayesian based markov chain monte carlo simulation
diverse classes ligands recently discovered airway smooth muscle despite transient increase intracellular calcium concentrations however cellular mechanisms understood calcium activated actin protein found many cell types including cells also binds making substrate less available phospholipase beta mediated hydrolysis hypothesized plays critical role relaxation mechanistically accounts relaxation ligands transiently increase isolated rings knockout mice showed impaired relaxation beta agonist taste receptor agonist despite inducing transiently increased single inhalation increased lung resistance similar extent wild type mice subsequent spontaneous relaxation less mice cells derived mice serotonin induced coupled activation increased synthesis greater extent compared cells wild type mice possibly due absence binding single cell analysis showed higher actin ratio baseline slower cytoskeletal remodeling dynamics cells cells also showed attenuated decrease cell stiffness acid findings suggest plays critical role relaxation activation contribute relaxation induced ligands despite transient increase
aim study examine upper respiratory tract infections associations resting saliva blood immune endocrine parameters ice players twenty seven participants age years completed week study period counts concentrations immune endocrine markers compared healthy prone athletes episodes state athletes infections healthy state time without differences concentration counts saliva blood immune endocrine parameters illness prone illness free athletes athletes significantly lower concentrations respectively significantly higher neutrophil monocyte count values concentration time symptoms period without symptoms infections differences salivary cortisol concentration period symptoms period without symptoms conclusion observed lower concentrations salivary higher levels blood immune parameters athletes confirm suppression mucosal immunity initiation responses pathogenic infections innate immunity
objective build mouse osteoblast mouse osteoclast culture system study effect activity osteoblasts osteoclasts culture system methods vitro acquisition cultivation mouse osteoblasts mouse cells conducted osteoblast osteoclast activities cells detected staining experiment red staining resistant acid phosphatase trap staining used different concentrations interfere osteoblast osteoclast culture system effects various genes detected pcr western blot methods correction expression ppar gamma bmd analyzed patients osteoporosis results mouse osteoblast osteoclast culture system built osteogenic differentiation effect enhanced improve osteogenic differentiation activity enhance expression rankl gene protein reduce gene protein expression increase alp tgf rankl gene expression level reduce rank gene expression act cells cells culture system promote osteogenic activity cells inhibit osteoclast activity cells reduce level differentiation expression level ppar gene negatively correlated level bmd conclusions mouse cells mouse cells cultured vitro improve osteogenic activity cells cells decrease osteoclast activity inhibit differentiation osteoblast osteoclast culture promoting osteogenic differentiation inhibiting osteoclast differentiation elsevier masson sas rights reserved
paper presents optimal bid day ahead electricity market problem joint operation wind photovoltaic power systems energy storage device uncertainty due electricity market price also due wind photovoltaic powers one main characteristics problem formulated two stage stochastic programming problem optimal energy flow batteries first stage variables energy deviation second stage variable problem energy storage way harness renewable energy conversion allowing store discharge energy conveniently market prices case study data day ahead electricity market presented comparison joint operations discussed elsevier ltd rights reserved
growing concern parenting negative consequences college students academic achievement goal study examine effects parenting constructs related academic achievement success motivation learning survey data presented college students mothers childrens report maternal parenting related extrinsic motivation learn discrepancy avoidance goals learning associated lower academic performance prior research mothers report parenting related childrens sense study suggests parenting related maladaptive academic motivations negative implications academic achievement
lysosomal storage disorders inherited diseases characterized lysosomal dysfunction often showing neurodegenerative course cure treat central nervous system moreover mechanisms driving neuronal degeneration pathological conditions remain largely unknown studying mouse models found neurodegeneration develops progressively profound alterations structure function models impaired lysosomal activity causes massive accumulation insoluble synuclein increased degradation cysteine string protein result availability synuclein nerve terminals strongly decreases thus inhibiting soluble attachment receptor complex assembly synaptic vesicle recycling aberrant phenotype mice genetic ablation one allele synuclein overexpression brain mouse model type severe form efficiently established complex assembly thereby ameliorating function attenuating neurodegenerative signs survival data show neurodegenerative processes associated lysosomal dysfunction initiated concomitant reduction synuclein levels nerve terminals also demonstrate neurodegeneration establishing functions thus identifying synapse maintenance novel potentially target brain treatment
objective objective present study analyze surgical safety retaining glands thyroid patients methods cases retrospectively reviewed divided four groups according treatment group conservative follow group cases group total resection unilateral gland combined resection cases group total resection unilateral gland combined resection contralateral gland cases group total resection bilateral glands cases average follow time months results occurrence rate hypothyroidism injury recurrent laryngeal nerve total occurrence rate group significantly lower group group differences statistically significant survival time months group months group months group survival time group significantly less groups difference statistically significant conclusions total resection unilateral gland combined resection gland functionality reduces complications maintains survival time therefore clinical application
contaminants emerging concern often poorly removed wastewater using conventional treatment technologies limited understanding fate treatment inappropriate sampling strategies lead estimating study used approach accounts residence time distribution treatment units investigate fate target municipal wastewater treatment plant includes primary secondary tertiary treatment steps prior hydraulic calibration treatment unit performed wastewater sludge samples collected different locations along treatment train concentrations target measured liquid chromatography mass spectrometry substantial aqueous removal occurred activated sludge treatment primary tertiary rotating biological sand filtration mass balance calculations demonstrated bio degradation accounted removal primary activated sludge removal primary secondary sludge minimal analysis selected metabolites demonstrated negative obtained explained transformations parent compound metabolites study contributes growing literature applying approach calculate removal different types across wastewater treatment step additional level understanding fate provided mass balance calculations primary secondary treatments elsevier rights reserved
component human metabolism two industrial environmental pollutants bladder viz responsible besides capability form three dna also metabolized hepatic enzymes investigate metabolism human hepatic microsomes identify major enzymes involved process aims study metabolized human hepatic microsomes predominantly one parent formed two metabolites whose exact structures identified yet minor products selective inhibitors nadph cyp reductase cytochrome reductase used characterize human liver enzymes reducing based studies attribute main activity metabolic step human liver enzymes also metabolism human liver similar among human recombinant cyp enzymes tested study human followed efficient enzymes results found study indicate spontaneous decomposition ions generating dna susceptibility metabolism cyp enzymes elsevier rights reserved
known kidney plays important role development cardiovascular diseases hypertension normal aging process leads changes kidney morphology function increase incidence cardiovascular events elderly population disturbances influenced several factors including gender general females protected effects estrogens system several studies demonstrated beneficial effects estrogens renal function elderly however relationships androgens kidney health ones lifetime understood sex steroids many complex actions decline levels aging clearly influences kidney function decreases renal reserve facilitates development cardiovascular disorders therefore review discuss cellular biochemical molecular mechanisms sex hormones influence renal function aging process
background second abundant earth great target applications one ubiquitous bacterial lineages essential global carbon cycle many members highly efficient complex carbohydrates however despite specialist reputation carbohydrate conversion mechanisms degrading crystalline cellulose hitherto unknown results describe complete functional analysis novel utilization locus soil tailored conversion utilization locus consists eleven genes encoding carbohydrate capture transport proteins enzymes two component sensor regulator system key encoded atypical terms known affiliated mechanisms anchored outer cell membrane consists multiple catalytic domains demonstrate extraordinary efficiency derives synergy multiple acting previously unidentified binding domains reverse genetics show encoded proteins involved sugar binding sensing essential efficient utilization surprisingly encodes two pairs like outer membrane proteins ligand binding structural studies revealed functional differences two like proteins enhance scavenging environment combined results study provide insight mechanisms employed degrade reveal important novel aspects paradigm conclusions combining reverse genetics map essential genes structural studies outer membrane binding proteins enzymology provide insight mechanisms employed degrade introduce new mechanism used presented discovery analysis greatly benefit future enzyme discovery efforts studies regarding enzymatic
contribution review recent nmr studies hydrogen bond states phosphate model bases different environments starting aqueous solution organic solid state polar organic solution finally enzyme environments established hydrogen bond correlations allow one estimate hydrogen bond geometries chemical shifts shown ring aspartate aminotransferase achieved hydrogen bond aspartate residue assisted group side chain local polarity found related model systems polar organic solvent exhibiting dielectric constant model studies indicate ring leads dominance form hydrogen bond exhibits state thus moiety carries net positive charge considered pre initiate enzyme reaction however shown form absence ring polar groups water finally differences acid base interactions aqueous solution interior proteins discussed article part special issue entitled phosphate enzymology published elsevier
recently proposed secure two party based key exchange protocol utilizing semi group property chaotic maps exploit vulnerability protocol paper illustrating line attack attack user recover attacker without noticed server victim overcome problem propose simple compatible fix
background estimated one billion children experience child abuse year highest rates low middle income countries teen programme part parenting lifelong health initiative develop test violence prevention programmes implementation low resource contexts objectives parenting support programme prevent abuse adolescents improve parenting reduce adolescent behavioural problems trial aims evaluate effectiveness teen compared attention control group water hygiene programme methods design pragmatic cluster randomised controlled trial stratified rural peri urban study clusters eastern south africa receive either session parenting support programme day water hygiene programme primary outcomes child abuse parenting practices secondary outcomes include adolescent behavioural problems mental health social support concurrent process evaluation qualitative research conducted outcomes reported primary caregivers adolescents brief follow measures collected immediately intervention full follow measures collected months post intervention month follow planned depend financial practical feasibility given delays related high levels ongoing civil political violence research sites discussion first known trial parenting programme prevent abuse adolescents low middle income country study also examine potential mediating pathways moderating factors
clinical epilepsy migraine cause visual difficult many cases lead overview differentiating features concerning presented furthermore discuss characteristics children idiopathic focal occipital lobe types headache adults epilepsy
data lie space symmetric positive definite matrices sometimes called tensor data play fundamental role applications including medical imaging computer vision radar signal processing open challenge applications find class probability distributions able capture statistical properties data arise real world situations present paper meets challenge introducing gaussian distributions distributions kind first considered however present paper gives exact expression probability density function first time existing literature leads two original contributions first detailed study statistical inference gaussian distributions connection maximum likelihood estimation concept centre mass widely used applications second derivation implementation expectation algorithm estimation mixtures gaussian distributions paper applies new algorithm classification data problem texture classification computer vision showing yields significantly better performance comparison recent approaches
paper presents description technical characteristics autonomous station developed pacific institute far eastern branch russian academy sciences stationary measurements variations acoustic pressure frequency range shelf bottom organize real time monitoring parameters seismic survey impulse signals industrial acoustic noise station additionally equipped digital radio channel acoustic data measured frequency band transmitted channel post via satellite radio channel controls operation radio transmitter results special analysis acoustic data obtained subsequent min time intervals
objective effect infection recipients poorly understood methods evaluated recipients detected nested qualitative polymerase chain reaction pcr assays urine risk factors virus virus analysed kidney liver functions infected uninfected patients compared results virus virus virus detected recipients respectively infection found independent risk factor virus infection odds ratio hla susceptible virus infection liver function virus infected subjects worse uninfected subjects conclusion opportunistic infections recipients especially infection hla transplant unexplained liver function deterioration observed virus infection considered
order obtain precise measurements position agents located considerable distance using sensor system based position sensitive detectors necessary analyze mitigate factors generate substantial errors systems response sources error divided electronic geometric factors former stem nature construction performance electronic response system latter related sensors optical system focus solely electrical effects since study analysis correction prerequisite subsequently addressing geometric errors simple calibration method proposed considers response component temperature variations signal frequency used signal noise ratio snr suboptimal operational amplifier parameters analog digital converter adc quantitation etc following analysis effects calibration sensor possible correct errors thus rendering effects negligible reported results section
soil water evaporation cropping surface loss potentially productive rainwater thus efficient use rainwater help sustain production purpose study quantify effect canopy levels soil water evaporation section field rainwater harvesting evaluate alpha beta soil evaporation models effect surface treatments method used measure maize canopy three consecutive drying cycles across basin runoff sections fine sandy soil first main effects four runoff strip lengths three treatments statistically analysed weighted values second treatments allocated main plots four levels allocated according lengths runoff sections third cumulative sigma measurements used evaluate empirical equations related time alpha potential evaporation beta two models compared considering effects surface treatments significantly higher observed bare treatment compared either two treatments viz level cover significant differences found treatments insignificant effect treatments implied dynamics spatial distribution soil water energy influenced evaporation result green cover canopy less suppressive properties developed bare surface efficient restriction found high cover treatments alpha beta values ranged respectively treatments simulated sigma underestimated model overestimated model main effect due dominant effect energy limited evaporation stage treatments mainly driven soil limited stage stage evaporation model performed estimate sigma basin area potential model runoff strips cropping system changed according surface treatments highly influenced losses production elsevier rights reserved
explore putative correlation sequence types antifungal susceptibility clinical candida isolates china eighty two clinical isolates collected sixty nine patients hospital shanghai university school medicine shanghai china july february antifungal susceptibility tests performed genetic profiles isolates resistant susceptible characterised sequence typing phylogenetic analysis data conducted clustering method using pair group method arithmetic minimal spanning tree algorithm clonal clusters analysed using package six gene fragments identified sequence typing presented highest typing efficiency whereas least efficient sequence types differentiated genotypes identified new database twenty assigned seven major groups based analysis group contained accounted resistant isolates however genetic relationships among susceptible relatively analysis putative correlation types antifungal susceptibility clinical isolates china shows closely related resistant clones elsevier rights reserved
design method initial topology interior permanent magnet synchronous machine hybrid electric vehicle hev propulsion described paper design constraints selected basis limitations imposed machines manufacturer application maximum copper slot fill factor air gap length permanent magnet material limited space available drive trains etc design variables rotor radius stator slot width number turns per phase winding parametric analysis performed various machine topologies cost function distribution operating points hev efficiency maps various topologies electrical machine defined obtained parametric results compared find result leading extreme value cost function initial design corresponds result considered best initial design
goal article reflect role robotics played college engineering education last years starting introduction introduction combining modular computer programming language modular building platform education allowed students ages become active leaders education build animals robotic robots play childrens games importantly allows students develop different solutions problem provide learning community look first recent developments learning sciences help promoting student learning robotics share four case studies successful college level implementations build developments
background ovarian cancer leading lethal malignancy united states continued morbidity mortality ovarian cancer reflects poor understanding invasive mechanisms recent studies reveal ovarian cancers express aberrant micrornas mirnas oncogenic tumor suppressor properties several studies suggested mir involved tumorigenesis presently investigate molecular mechanisms target mir ovarian cancer methods quantitative real time polymerase chain reaction western blot performed assess mir transcription factor expression ovarian cancer normal ovary samples effect mir determined luciferase reporter assay western blot effect mir cell invasion using transwell invasion assay result mir expression increased ovarian cancer promoted invasive behavior ovarian cancer cell lines mir directly targeted significantly decreased ovarian cancer tissue mir inhibited expression consequence blunted inhibitory effect cell invasion matrix play important role cancer invasion metastasis inhibited mmp mmp decreased ovarian cancer cell invasion transfection expression plasmid mir mimic diminished inhibitory effect mmp mmp ovarian cancer cells conclusion mir appears important role spread ovarian cancer targeting findings offer new mechanism ovarian cancer tumorigenesis useful development new therapeutic approaches ovarian cancer treatment
achieve high performance control modern converters using direct digital design techniques accurate discrete model converter necessary paper new parametric system identification method based kalman filter approach introduced estimate discrete model synchronous buck converter improve tracking performance proposed adaptive tuning technique proposed unlike many published schemes approach offers unique advantage updating parameter vector coefficients different rates proposed estimation technique experimentally verified using texas instruments micro controller platform synchronous step converter results demonstrate robust reliable real time estimator proposed method accurately identify discrete coefficients converter paper also performance identification algorithm time varying parameters load change proposed method demonstrates robust estimation without excitation signal makes suited real time power electronic control applications furthermore estimator convergence time significantly shorter compared many schemes classical exponentially weighted recursive least squares method
introduction obesity rapidly becoming poses serious health risk individuals abdominal obesity quite common india prime risk factor diseases like diabetes coronary artery disease gastroesophageal reflux disease osteoarthritis etc complex multifactorial exists presence obesity current study focuses high body mass index bmi marker obesity risk factor aims better understanding complex association aim study association bmi symptoms gross endoscopic appearance gastroesophageal reflux disease materials methods prospective cross sectional study carried tertiary care hospital india january june total patients referred upper gastrointestinal endoscopy due symptoms two months duration selected bmi weight square height calculated patients classified normal weight bmi overweight bmi obese bmi frequency severity symptoms assessed self administered questionnaire data typical atypical symptoms collected upper endoscopy done patients based gross endoscopic appearance disease divided endoscopy negative reflux disease true per los staging system association bmi frequency severity type symptoms also bmi gross endoscopic studied using various statistical tests tests two confidence level value considered statistically significant results typical symptoms acidic present subjects frequency severity symptoms increased significantly increasing bmi based endoscopic gross appearance mucosa participants disease high bmi statistically significant relationship occurrence statistically insignificant relationship classification system endoscopic conclusion prevalence frequency severity symptoms increases increase bmi significant correlation increasing bmi staging classification endoscopic independent bmi patients
paper study generalized coupled variable coefficient modified system models two layer fluid applied investigate atmospheric phenomena atmospheric interactions atmosphere ocean conservation laws system derived using multiplier approach new conservation theorem addition similarity reduction exact solutions aid symbolic computation computed
recently ubiquitous manufacturing attracted wide attention academia industry create successful ubiquitous manufacturing system efficient material handling system essential accordance reason mobile robots used materials paper aims developing methodology scheduling material supply single mobile robot ubiquitous manufacturing environment type environment processing rate materials along supply quantity corresponds cycle material supply carrying capacity robots limited thus problem determining material supply quantity material supply schedule without lack materials production service processes becomes complicated work nonlinear program formulated schedule supply material determine required material quantity heuristic algorithm based genetic algorithm developed solve problem numerical experiments conducted study observed proposed algorithm shows good performance also implemented solve large scale problems elsevier ltd rights reserved
electric motor driving compressor cause large power electric systems result necessary circuit require reactive compensation equipment increase voltage stability supply system driven synchronous asynchronous motors due characteristics synchronous motors widespread studied compared induction motors recent years extensive use electric drives induction motors increasingly involved implementation compression trains first time analysis compression train made considering induction motor simple inertia synchronous motor recently effects air gap torque considered induction motor model allowing simulate accurately entire system paper transient power evaluation compressor train based air gap torque effects electric motor presented analysis involves electrical parts mechanical parts equations derived matlab simulink model realized finally verify proposed procedure real compressor train simulated
introduction spinal rare disease causes cord compression neurologic deficit spontaneous related minor trauma bleeding disorders anticoagulant medications posttraumatic associated low energy spine injuries patients ankylosing spinal disorders ankylosing spondylitis diffuse idiopathic skeletal variant named atypical like reported objective describe management diagnosis treatment unusual case patient causing delayed neurologic deficit rigid atypical like spine case description elderly woman prior antiplatelet therapy presented delayed neurological deficit suffering trauma falling computed tomography imaging studies reveal fracture pattern signs mimic missed standard ray images magnetic resonance study demonstrates posterior mass compatible thoracic spine cord compression using posterior approach urgent intervention left multiple partial unilateral long instrumented fusion performed achieving spinal stability neurological improvement observed conclusion patients rigid spine sustain low energy injuries prone fracture especially take anticoagulant medications imaging studies including scans reviewed carefully rule fracture urgent early surgical drainage instrumented fusion performed achieve stability functional recovery
background androgen receptor knockout male mice display hepatic suggesting signaling regulate hepatic fat however effects testosterone replacement hepatic fat men unknown aim study determine effects testosterone administration hepatic fat older men mobility limitation low testosterone levels participating randomized trial testosterone older men trial methods two hundred nine men mobility limitation low total free testosterone randomized parent trial either placebo testosterone gel daily months hepatic fat determined magnetic resonance imaging men placebo testosterone group using volumetric method insulin sensitivity homeostatic model assessment insulin resistance derived fasting glucose insulin results baseline characteristics similar two groups including liver volumes testosterone group placebo group testosterone concentrations increased testosterone group change placebo group changes liver volume intervention differ significantly groups related treatment testosterone concentrations change homeostatic model assessment insulin resistance also differ significantly groups related either baseline change liver fat conclusion testosterone administration older men mobility limitation low testosterone levels associated reduction hepatic fat larger trials needed determine whether testosterone replacement improves liver fat men hepatic
theoretical experimental study microcontroller based dual axis automatic solar tracking system presented paper panel automatically based intensity sun light helps keeping solar panels aligned sun order obtain maximum solar power instance particular alignment intensity light decreasing system ability automatically get maximum intensity light light energy detected four dependent resistor sensors located surface photovoltaic panel two servo motors employed move solar panel direction maximum intensity design construction small prototype presented measured efficiency fixed solar panel
global existence large data hyperbolic fluid models often restrictions size relaxation parameter depending size initial data therefore leave general question large data open note show results corresponding model problems underline complexity question hence also show strength global existence small parameters elsevier ltd rights reserved
background angioedema due hereditary deficiency inhibitor causes temporarily disability guidelines recommend early demand treatment attacks reduce morbidity prospective observational study evaluated efficacy demand approach methods january august data attacks treatments collected patients centre results total attacks reported treated approved therapies inh acid treated attack locations peripheral cutaneous abdominal multiple facial laryngeal attack moderate mild severe median attack duration data available attacks approved therapies significantly shorter without treatment acid treatments self administered inh median attack duration inh median time onset symptoms drug administration median time drug administration complete resolution respectively second treatment required treated attacks inh treated attacks conclusion study provides evidence demand treatment effective reducing disease related morbidity use demand treatment italy increased attacks last years reflecting better adherence international guidelines
aim research investigate causes emergence sports injuries explain differences psychological response regard severity injury examined competing athletes surgically treated knee injury estimated time rehabilitation severely injured athletes six months sustained less severe injuries faced month long rehabilitation measured athletes personality traits athletic identity coping pain rehabilitation beliefs motivation social support provided family colleagues results showed group severely injured athletes demonstrated behaviour less inhibited response group athletes less severe injuries psychological response proved almost groups except higher levels higher individual coping response found group severely injured athletes furthermore masculinity found predict self efficacy individual coping response strength athletic identity predicted motivation rehabilitation value emotional predicted self efficacy athletes lower athletic identity lower masculinity higher emotional exposed adjustment difficulties sustaining athletic injury opinion strategies successful rehabilitation sports injury aimed identification athletes personality traits pose higher risk experiencing adjustment difficulties promoting adequate motivation increasing support application cognitive behavioural strategies
rationale report first case syndrome thrombocytopenia myelofibrosis renal dysfunction latin america patient concerns patient year old white woman descent presented history days nausea vomiting fever severe edema legs splenomegaly lymph nodes diagnoses abdominal computed tomography showed bilateral lymph node enlargement interventions worsening renal function led admission intensive care unit icu multiple organ failure requiring mechanical ventilation medications continuous renal replacement therapy diagnosis syndrome made day admission based clinical findings results bone marrow lymph node biopsies treated rituximab one week first dose dramatic improvements respiratory hemodynamic status support medications outcomes weeks therapy switched intermittent day patient discharged icu general ward months admission went home lessons provided interleukin measurement available approach suggested cases syndrome order treatment
design proportional integral derivative pid controllers based principles various types integrating systems time delay proposed pid parameters given terms process model parameters tuning parameter tuning parameter filter time constant present work filter chosen manner order controller one less order filter time constant tuned way good compromise made performance robustness servo regulatory problems improve servo response controller set point filter designed closed loop response similar first order plus time delay system proposed controller design method applied various transfer function models non linear model equations demonstrate applicability effectiveness performance proposed controller compared recently reported methods terms smooth functioning controller determined terms total variation compared recently reported methods simulation studies carried various integrating systems time delay show effectiveness superiority proposed controllers published elsevier ltd rights reserved
study objectives determine effects aerobic exercise compared usual activity objective assessments sleep women methods secondary analyses randomized controlled trial menopause strategies finding lasting answers symptoms health network conducted among late transition postmenopausal women aged hot women randomized supervised aerobic exercise usual activity mean coefficient variation change sleep measures intervention group compared usual activity group using linear regression models results baseline values primary sleep measures entire sample mean total sleep time min mean wake sleep onset min mean mean number long min changes sleep outcomes baseline weeks small none differed groups exploratory analysis women baseline pittsburgh sleep quality index higher significantly reduced following compared usual activity conclusions study adds currently scant literature objective sleep outcomes aerobic exercise interventions population although small effects self reported sleep quality previously reported interventions statistically significant effects measures except potentially improved sleep stability women poor self reported sleep quality
aim objectives research focused analysis motor skills children autism spectrum disorder asd used special speech language therapy software programme evaluate quality movements children asd research strategy based relations motor problems disturbed nonverbal communication patterns generally influenced even children asd main focus research emerged wider focus assessment pragmatic language level represents one deficit area persons asd believe ability production facial expression gestures represents one important part pragmatic nonverbal communication activities methodology assessed motor abilities children asd initial final phase examination used selected part software programme multimedia programme therapy clients impaired communication ability evaluation progress child used observational numerical scale evaluation subsequently compared difference phases longitudinal observation conclusions results proved possibility achieving least partial positive results based application systematic speech language therapeutic approach based using speech
background objectives psoriasis inflammatory skin disease associated metabolic syndrome insulin resistance regulates metabolic status times increased insulin sensitivity study aimed investigate changes serum level psoriasis patients comparison participants disease control group hope results study also aid establishing protocol aimed understanding treatment psoriasis materials methods study included patients psoriasis vulgaris presented dermatology outpatient clinic receiving systemic treatment control group included voluntary participants disease addition venous salivary levels glucose triglyceride cholesterol high density lipoprotein low density lipoprotein levels homeostasis model assessment insulin resistance scores measured control patient groups results serum salivary levels significantly lower patient group compared control group patient group serum levels positive correlation salivary levels negative correlation psoriasis area severity index dermatological life quality index scores conclusion first study evaluating levels patients psoriasis vulgaris literature results study show serum salivary levels significantly lower patient group compared control group levels patients severe psoriasis low suggesting role pathogenesis psoriasis marker showing severity psoriasis development insulin resistance diabetes mellitus copyright taiwanese dermatological association published elsevier taiwan llc
natural killer cell lymphoma nasal type rare subtype non hodgkin lymphoma treatment outcome previously poor novel treatment strategies improved outcomes remarkably last decade nowadays patients localized nasal recommended treatment concurrent year overall survival rate approximately patients advanced relapsed refractory disease efficacy containing therapy confirmed however still remain unmet needs treatment continued efforts made improvements treatment
parametric implicit methods traditionally thought two irrelevant approaches structural shape optimization parametric method works lagrangian approach often uses parametric boundary representation curves surfaces example combination conformal mesh finite element model implicit method relies upon level set functions implicit functions works approach combination fixed mesh within scope extended finite element method finite cell method original contribution work methods first new shape optimization method proposed combining features parametric implicit shape changes structural boundary governed parametric fixed mesh maintain merit computer aided design modeling avoid second analytical shape design sensitivity formulated parametric framework fixed mesh finite cell method means hamilton equation numerical examples solved illustrate unified methodology copyright john wiley sons ltd
exposure fruit ethylene leads acute placental tissue mrna differential display strategy utilized isolate characterize genes associated development disorder fruit harvested full stage exposed ethylene degrees dna free total rna isolated fruit treated air ethylene reverse transcribed using three different one base anchored primers high pcr performed using eight different arbitrary primers combination fluorescent labeled one base anchored primers pcr fluorescent labeled products separated polyacrylamide sequencing gel differentially expressed bands isolated confirmation true positive bands performed reverse northern blotting comparison mrna profiles ethylene air treated fruit revealed genes differentially expressed partial isolated characterized blast search results revealed significant ethylene biosynthesis signal transduction pathway genes lipid enzymes proteins involved plant defense responses radical scavenging enzymes northern blot analysis rna isolated air ethylene treated fruit stored revealed ethylene dependent expression pattern corresponding genes data indicate ethylene treatment fruit results rapid regulation oxidative enzymes elsevier rights reserved
despite eliminating incidences many diseases united states parents increasingly vaccines children article examines reasons parents offer argues parents construct natural artificial vaccines come seen unnecessary ineffective potentially dangerous using qualitative data interviews observations article shows first parents view childrens bodies particularly experiences birth infants naturally perfect need protection second parents see vaccines artificial intervention body injection third parents perceive immunity occurring illness natural superior immunity derived vaccines inferior potentially dangerous finally parents highlight ways natural living serves enhance childrens immunity rendering vaccines unnecessary taken together allows parents justify rejection vaccines form protecting childrens health findings expose perceptions science technology health meanings body ways inform public health efforts elsevier ltd rights reserved
thermodynamic analyses focused determination theoretical equilibrium concentrations based sulfur compounds possible hydrogen removal temperature range upstream selective deep removal gas minimization gibbs energy system used complicated situations lowest concentration ppm attained based temperatures oxidation based less efficient higher oxides limit preferred real gas presence gas phase leads formation lower efficiency removal thermodynamic analyses also focused suitable ways conditions regeneration spent corresponding oxides temperatures based spent regenerated reaction temperatures way elemental sulfur small concentrations theoretically produced formed decomposition full regeneration possible rather reaction steam based spent sulfur restored reaction vapor leading formation suitable operating conditions involve temperatures higher operating pressures potential small contents spent converted regeneration process elsevier ltd rights reserved
green tea green tea extracts often incorporated diet intended weight reduction although information efficacy obese individuals insufficient present study designed follow effect defined standardized mice obesity induced glutamate obese mice fed supplemented diet three dosage regimens day day intake diet day intake diet information body weight food intake oxidation stress parameters blood antioxidant enzymes activity liver small intestine obtained high doses decreased specific activities glutathione reductase catalase increased concentrations malondialdehyde blood specific activities antioxidant enzymes liver small intestine altered treatment except decrease nad activity results showed affect average body weight markedly improve antioxidant status glutamate induced obese mice moreover intake high doses made antioxidant defense obese animals even worse
schedules americans live consistent healthy sleep patterns addition poor access educational treatment aids sleep leaves people engaging behavior harmful sleep treatment sleep disorders created sleep crisis public health issue broad implications cognitive outcomes mental health physical health work performance safety new public policies formulated address issues draw scientific literature recommend following establishing national standards middle high school start times later day stronger regulation work hours schedules eliminating daylight saving time educating public regarding impact electronic media sleep improving access ambulatory home diagnostic testing sleep disorders
recent advancements micro object becoming essential part biomedical sector help avoid infection damage occur due external contact context smart micro conveyor devised field programmable gate array fpga based system employs smart surface along complementary metal oxide semiconductor cmos camera micro object position detection tracking specific fpga based hardware design high speed integrated circuit hardware description language implementation realized done without employing processor system programmable chip based central processing unit cpu core keeps system efficient terms resource utilization power consumption micro object positioning status captured embedded fpga based camera driver communicated image processing decision making command module programmed run personal computer appropriate embedded system decisions sent back fpga smart surface accordingly way automated closed loop system employed convey micro object towards desired location devised system architecture implementation principle described functionality also verified results confirmed proper functionality developed system along compared solutions
psoriasis skin lesions characterized dramatic changes transcriptome reflecting altered activity multiple signalling pathways resident infiltrating cells mirnas small non coding rnas large impact cellular functions regulating multiple genes simultaneously shown play key roles skin inflammation commentary review article micrornas psoriasis immunological functions potential biomarkers role mirnas psoriasis diagnostic therapeutic potential discussed remaining unanswered questions highlighted
junction specialized structure system force transmitted muscle tendon animal models shown takes form tendon finger like processes merging muscle tissue human largely unknown never described three dimensions aim study describe human render reconstructions fourteen subjects age years isolated injury anterior cruciate ligament acl scheduled reconstruction graft included acl reconstruction isolated prepared transmission electron microscopy tem focused ion beam scanning electron microscopy possible isolate tissue patients tem images displayed similarities observations animals observed finger like processes tendon surrounding muscle fibers extending final line muscle fiber merging tendon tissue reconstruction revealed tendon made like like muscle cell
propose successive improved dynamic programming algorithm hydropower reservoir operation based analysis hydropower problems single period hydropower generation storage release marginal contributions hydropower generation also complementary effect storage release release becomes productive accordance increasing storage multiple period hydropower generation influences objective function operation decisions major cause complexity hydropower operation mathematical propose approximation hydropower generation function algorithm hydropower reservoir operation efficiency demonstrated two hypothetical case studies long term hydropower scheduling shows computation time increases linearly accordance number storage intervals whereas dynamic programming shows quadratic increase
herein examined insulin resistance insulin sensitivity beta cell activity glucose metabolism subjects antisocial personality disorder aspd whether serotonin receptor testosterone role energy metabolism cohort subjects belonging population included aspd males aged divided groups based presence heterozygous receptor loss function gene mutation serum glucose insulin levels measured oral glucose tolerance test indices describing beta cell activity calculated body mass index bmi also determined concentrations serotonin metabolite acid measured cerebrospinal fluid testosterone levels serum like state comprising high low high beta cell activity indices observed among aspd subjects without allele contrast aspd carrier appeared preventive allele testosterone predicted lower bmi independently interaction testosterone lead increased insulin sensitivity among carriers low testosterone levels allele also predicted reduced beta cell activity enhanced glucose metabolism reduced receptor function low normal testosterone levels protective obesity results observed among finnish males antisocial personality disorder limits elsevier ltd rights reserved
many species face trade additional mating opportunities offspring benefits viability quality provided parental care female egg otherwise carry involve risks offspring fungal infection assessed whether males discriminate egg carrying females according egg development stage females influenced egg development stage regard offspring less likely survive due high humidity absence egg carrying females apparently males distinguish females according developmental stage eggs carried however females likely carrying relatively mature versus immature eggs days days post respectively egg successfully egg carrying females avoided fungal infections high humidity thus females face trade mating parental care research clarify females females prevent egg infected fungi
cell specific restriction viral replication without concomitant attenuation benefit vaccine development gene therapy understanding biological properties viruses several mechanisms regulating viral however tend virus class specific many result virus attenuation additionally many viruses including exhibit size constraints allow incorporation large amounts foreign genetic material required targeting methods micrornas short non coding rnas regulate gene expression eukaryotic cells binding complementary target sequences messenger rnas preventing translation accelerating degradation different cells exhibit distinct microrna signatures many micrornas serve biomarkers differential expression patterns exploited restricting gene expression cells express specific micrornas maintaining expression cells regards regulating viral sequences complementary specific micrornas incorporated viral genome generally non coding regions targeting destruction presence micrornas thus preventing viral gene expression replication microrna targeting technique theoretically applied viral vectors without altering potency virus absence corresponding micrornas describe experimental methods associated generating microrna targeted evaluating efficacy specificity targeting vitro protocol designed rapidly replicating virus replication cycle however modification time points analyzed specific virus titration used aid adaptation protocol many different viruses
simultaneous bidirectional single wire developed cmos technology command control bus echo signals simultaneous bidirectional link controlling decision level receiver without power operational amplifier amp based circuits clock information embedded rising edges signals sent source side sink side data recovered open loop digital circuit times blind data rate simultaneous bidirectional direction therefore overall signaling bandwidth measured energy efficiency bit error rate less pseudo random binary sequence pattern signaling directions
discourse low income mothers frames social problems deficiency reflected studies parenting practices scholars often underestimate low income mothers parenting logic recognize mothers work hard use appropriately different parenting middle class mothers investigate parenting african american white low income mothers women demonstrate logic follows many middle class parenting strategies additionally seeks address obstacles prevent low income youth reaching goals addiction drug dealing pregnancy street logic leads strategies appear inexpensive adaptations middle class practices however analysis mothers narratives reveals derivative intended prepare children avoid social context study previously version intensive
law enforcement represents unpredictable work environment range physical tasks demanding high levels strength muscular power anaerobic power aerobic endurance common injuries among include sprains strains back ankle predominant injury sites relying published research evidence established systematic exercise program design procedures exercise professionals create effective job specific training programs law enforcement law enforcement represent athletes need deserve advanced exercise prescription safely effectively meet demands jobs throughout careers
urban stormwater major cause urban flooding natural water pollution therefore important assess hydrologic trends urban stormwater management planning study addresses urban hydrological trend analysis examining trends variables characterize hydrological processes original modified mann methods applied trend detection two french based approximately data local monitoring programs trend found major hydrological process driver rainfall variables whereas increasing trends detected runoff flow rates consequence runoff coefficients tend increase study period probably due growing local urbanization process addition conceptual urban rainfall runoff model parameters identified via model calibration event based approach examined trend detection results indicate trend time concentration whereas decreasing trend present however needs validated additional data sensitivity analysis indicates original mann method sensitive noisy values data series
context methods processes along tools support heart software engineering discipline however know often use method neither impacts software projects comparable manner software result lacking understanding methods affect software development objective article develops set concepts based practice concept philosophy base describe software development social practice develop understanding methods application explains heterogeneity outcome practice understood opposed theory commonly agreed upon way acting acknowledged team method article applies concepts philosophy social theory describe software development develops concepts method method usage results steps exemplified using published empirical research results article develops conceptual base understanding software development social practices defines methods practice patterns need related integrated existing development practice application method conceptualized development practice practice certain aspects aligned description method method always defines practice implication research industrial software development teaching indicated conclusion theoretical concepts allow explaining heterogeneity application software engineering methods line empirical research results elsevier rights reserved
brain derived neurotrophic factor bdnf tyrosine kinase receptor reported associated poor prognosis neuroblastoma patients previous studies indicated bdnf activation induces resistance activation kinase akt pathway study investigated role bdnf metastasis regulated expressing cell line used scratch wound healing assay chamber migration invasion assays performed study migration invasion cells tumor xenograft model using scid mice utilized detect metastasis tumors vivo inhibitors mapk akt mtor used western blotting performed study expressions akt erk mtor results showed expressing cells bdnf treatment significantly increased gap closing scratch wound healing assay also significantly enhanced numbers cells cells chamber migration invasion assays vivo distant metastases significantly increased mice expressing xenograft tumors compared non expressing tumors pre treatment inhibitors mapk akt mtor rapamycin blocked bdnf induced increases cell migration invasion cells also blocked bdnf induced expressions akt erk mtor data indicated bdnf increased metastasis via akt mtor mapk pathways bdnf downstream targets potential targets treatment metastasis
task scheduling one major issues achieve high performance distributed systems grid peer peer cloud environment generally two phases heuristics based task scheduling algorithms heterogeneous distributed computing systems phases task prioritization processor assigning respectively heuristic based task scheduling algorithms use different policies assign priority produce different heterogeneous computing system thus suitable scheduling algorithm one efficiently assign priority tasks order minimize recently algorithms mas used evolutionary population based global search approaches local search heuristic optimize complete problems recent studies mas discovered success wide variety real world problems since task scheduling problem complete paper new task scheduling algorithm cloud environment using multiple priority algorithm proposed proposed method uses genetic algorithm along assign priority using heuristic based earliest finish time approach search solution task processor mapping basic idea approach using advantage increase convergence speed solutions implemented algorithm cloud service language experimental results set randomly generated graphs revealed proposed algorithm outperformed existing three task scheduling algorithms terms fast convergence optimized solution
typically caused deficiencies precipitation soil moisture affect water resources agriculture soil moisture key importance understanding interaction atmosphere surface used monitor study high resolution soil moisture drought index proposed evaluated meteorological agricultural hydrological developed using soil moisture data produced advanced microwave scanning earth observing system march november korean seven products moderate resolution imaging modis tropical rainfall measuring mission satellite sensors used soil moisture based random forest machine learning soil moisture correlated situ soil moisture mean coefficient determination respectively standardized precipitation index time scales months crop yields data used validate various types results showed depicted meteorological drought especially dry season similar pattern month however performance bit wet season possibly due limited availability optical sensor data heterogeneous land covers around stations also showed high correlation crop yield data particular cultivated non irrigated regions mean however monitor hydrological drought presenting various range correlations data elsevier rights reserved
parental practices beliefs recognized important influence development childrens self regulation using mixed methods approach present study explored parental practices beliefs influence low income mexican american childrens self regulation fall preschool quantitative results indicated family learning environment parental control significantly related stronger self regulation mexican american children low income families qualitative interviews indicated respect educated emerged key factors guiding parents expectations childrens behaviors discipline additionally results indicated parents provide additional educational materials enrich home learning environment children study highlights importance understanding parental practices beliefs low income mexican american parents influence childrens self regulation better serve needs mexican american parents children
modeling cell migration features several glomerular diseases including vitro investigations recently identified central migration current study used array technology investigate expression genes cells identified platelet derived growth factor alpha polypeptide chain colony stimulating factor four members tumor necrosis factor alpha superfamily major genes upregulated transcriptional induction confirmed reverse transcription polymerase chain reaction northern blotting induction protein western blotting immunohistochemical localization observed associated cultures contrast models migration cells highest expression cell associated protein less evident however conditioned medium treatment removed cells suggesting localization owing association cell surface extracellular matrix first description expression human data suggest rapidly induced cells triggered migrate result induction currently investigation
background angiotensin receptor antagonists proposed replacement therapy occurrence either angiotensin converting enzyme ace inhibitor induced angioedema cough however recent studies indicate angioedema associated elevated bradykinin levels small fraction patients treated angiotensin receptor blockers suggesting common pathophysiological mechanism date standard treatment angiotensin receptor blocker induced angioedema exist methods present case series patients admitted hospital due angioedema induced angiotensin receptor blocker patients either treated either hydrogen patient groups compared untreated patient cohort patients previously diagnosed essential results effective therapy angiotensin receptor blocker induced angioedema full symptom recovery achieved hours whereas symptom remission occurred within hours patients treated untreated patients respectively recovery time similar described previous studies regarding therapeutic efficacy treatment hereditary angioedema patients suffering angiotensin converting enzyme inhibitor induced angioedema conclusions safe effective substance treatment angiotensin receptor blocker induced angioedema although pathophysiology angiotensin receptor blocker induced angioedema remains unclear appears associated bradykinin pathway
main purpose work describe case online java programming course engineering students learn computer programming practice non technical abilities online training self assessment teamwork use foreign languages important students develop confidence competence skills required later professional tasks engineering courses life long learning furthermore paper presents pedagogical methodology results drawn experience objective performance comparison another conventional face face java course
paper develops new framework analyze design iterative optimization algorithms built notion integral quadratic constraints robust control theory provide sufficient conditions stability complicated interconnected systems conditions checked programming discuss adapt theory study optimization algorithms proving new inequalities convex functions providing version theory adapted use optimization researchers using inequalities derive numerical upper bounds convergence rates gradient method heavy ball method accelerated method related variants solving small simple programming problems also briefly show techniques used search optimization algorithms desired performance characteristics establishing new methodology algorithm design
improving engines achieved use new electronic control systems combustion process additional installation devices catalysts oxidation fuel etc direction large number organizations work spend heavily research field processes friction surfaces showed certain conditions surfaces covered polymer film containing nanoparticles film capable reducing friction coefficient times essential order falling friction losses allows reducing fuel consumption internal combustion engine oils called energy saving oils possess effect reducing friction coefficient composition oils include coordinating transition metal compounds esters organic acids involved processes forming films investigated motor oil includes ester oil soluble coordination compound concentrate additives tests conducted internal combustion engine fixed part stand including single cylinder gasoline engine measuring tanks gasoline measuring block power meter bench tests shown fuel consumption reduced level reduced similar effect observed tested operating conditions passenger cars
aim formulate paradigm capable reflecting innovative practices delivering medicare patients specifically focusing rural remote parts region health therapy practice area service delivery model practice areas improves access occupational medical therapy services work presents medicare service health therapy capable providing immediate appropriate treatment early stages medical urge providing health services demand encourages researchers formulate system draw health graph patient foundation gathered parameters compare ideal graph formulated basis health form filled patient immediate relief graph health therapy attempts deliver initial treatment help diffusion mobile technology fuzzy database ambient intelligence health therapy diagnoses person near real time initial level medication patient recovering stable state till actual medical aid reach health therapy addresses person health take opportunity ask questions raise concerns
mental representation self complex construct comprising conceptual information perceptual information regarding body evidence suggests conceptual self representation bodily different aspects self linked changes bodily self representation appear affect self conceptualized unclear whether opposite relationship also true changes conceptual self representation affect physical self perceived first adopted perceptual matching paradigm establish association self unfamiliar face experiment robust attentional perceptual biases processing newly self associated object suggested conceptual self representation extended include next measured whether bodily self representation correspondingly changed incorporate new face experiment participants rated newly associated according similar self performing perceptual matching task changes conceptual self effect bodily self representation results suggest modulatory links aspects mental self representation focused self unidirectional flow bottom manner
endogenous non rna like sequences discovered genome wide range eukaryotes considered fossil rna viral elements integrated host genomes yet known mechanisms many cases estimated millions years old likely number records increase rapidly due growing availability whole genome sequences many kinds eukaryotes discovery novel understanding phylogenetic relationship modern viral relatives provide important information deep evolutionary history rna virus host interactions chapter therefore common strategies identification characterization endogenous plants insects fungi described
background mild traumatic brain injury represents treated brain injuries considerable proportion patients experience post symptoms prolonged period symptoms diagnosed persistent post syndrome defined range physical cognitive emotional symptoms however memory executive dysfunction seems one debilitating symptoms recently non invasive brain stimulation studied potential treatment method traumatic brain injury tbi patients therefore primary goal verify effects transcranial direct current stimulation patients demonstrate cognitive deficits long term episodic memory working memory executive function following methods design randomized crossover trial patients history cognitive deficits memory executive function thirty adult patients randomized crossover manner receive three weekly sessions left dorsolateral prefrontal cortex left temporal cortex sham stimulation performed day intervals period clinical diagnosis determined using post symptoms questionnaire patients meet inclusion criteria assessed neuropsychological evaluation new battery computerized neuropsychological tests performed immediately stimulation statistical analysis performed determine trends cognitive improvement discussion paucity studies regarding use tbi patients although recent results showed controversial data regarding effects patients address specifically patients brain abnormalities scan hemorrhage moreover due missing information literature regarding best brain region studied evaluate two different regions find immediate effects memory executive dysfunction
rainwater harvesting important technology cities contribute number functions sustainable water management face demand growth drought rainwater increase flood protection reduce damage objective article investigate integrity residential rainwater harvesting systems drawing results field inspection rainwater systems across combined survey situation maintenance behaviour attitudes specifically study moves beyond assumption rainwater systems always operational functional draws collected data explore various reasons rates failure associated pumps pump switches leaving later exploration failure components collection area tank best authors knowledge data like academic literature water sector straightforward bayesian network models constructed order analyse factors contributing various types failures including system age type use reason installation maintenance behaviour results show number issues commonly exist failure pumps systems automatic pump switches mediate tank water systems systems inadequate pump limiting use conclusion appears lack enforcement quality controls installation practices sometimes contractors lack ongoing maintenance mechanisms quality control asset management required difficult promote enforce work needed owned assets public benefits better managed crown copyright published elsevier rights reserved
humans brain accounts free cholesterol synthesized novo brain maintain cholesterol balance throughout life cholesterol becomes metabolized hydroxy cholesterol principally neurons mouse rat probably human metabolism accounts cholesterol turnover however route turned yet elucidated describe novel liquid chromatography multistage fragmentation mass spectrometry methodology identification high sensitivity low cholesterol metabolites rat brain methodology includes enhance ionization exact mass analysis high resolution identify potential metabolites allow characterization confirmed major rat brain identified first time brain included alpha alpha addition beta hydroxy two molecules linked proteins characterized rat brain
objectivesto evaluate often beta blockers started acute myocardial infarction ami nursing home residents previously use drugs evaluate factors associated post ami use beta blockers cohort using linked national minimum data set assessments online survey certification reporting records medicare claims cohort residents aged older hospitalized ami march taken beta blockers least months ami survived days longer outcome beta blocker initiation within days seven percent residents initiated beta blocker ami adjustment use beta blockers less older residents ranging odds ratio confidence interval aged less residents higher levels functional impairment dependent totally dependent independent limited assistance medication use medications wide variety resident characteristics associated beta blocker use including sex cognitive function comorbidity burden ownership half older residents united states initiate beta blocker ami absence observed factors strongly predict beta blocker use indicate lack consensus manage older residents suggesting need develop practice standards
indirect inference method implemented class stochastic volatility models financial data based non gaussian processes first quasi likelihood estimator derived gaussian state space representation model next data simulated model given parameter values indirect inference estimator obtained minimizing weighted mean squared error sense score vector quasi likelihood function simulated data score vector evaluated quasi likelihood estimator obtained real data method applied norwegian daily exchange rate data simulation study reveals quasi likelihood estimator large bias even large samples indirect inference estimator substantially reduces bias accompanying package interfaces code documented downloaded elsevier rights reserved
understanding cyclic post cyclic behaviours soil geosynthetic interface essential design geosynthetic reinforced soil structures repeated loads induced traffic paper series monotonic direct shear tests cyclic direct shear integrating monotonic direct shear tests conducted using large scale direct shear testing device effect normal stresses cyclic shear amplitude cycle number post cyclic behaviour interface investigated addition influence cyclic shear interface direct shear behaviour discussed detail test results indicated peak residual shear stresses interface post cyclic shear phase increased linearly normal stress number cycles volume contraction induced direct shear decreased increase normal stress interface apparent adhesion friction angle increased cyclic shear
operational amplifier basis analog circuit technology whose reliability important circuit system order collect parameters online assess working life operational amplifier parameters online testing system designed system consisted typical operating circuit electrical connection test circuit device test besides parameters tested test circuit collected data acquisition system values parameters displayed accelerated degradation test designed heat source back heat sink temperature heat source controlled finally life operational amplifier operating normal stresses assessed mathematical methods results indicate proposed method valid online life assessment operational amplifier
three educational institutions south develop pre engineering courses increase enrollment success students transferring college year degree programs science engineering south school technology south state university national science foundation colleges universities program activities led partnership native led valley community development provided significant opportunities students areas civil engineering sustainability recent opportunity includes incorporating plans person net zero regenerative community indian design course project includes sustainable design objectives wastewater treatment rainwater harvesting use compressed earth walls renewable building materials phase planned community four teams students working regenerative community four teams students working traditional design project completed proposals first progress reports fall semester comprehensive assessment team member effectiveness instrument administered twice semester evaluate team functioning comparison data two projects presented results surveys indicate students working regenerative community project positive consistent behavioral satisfaction categories within peer evaluation survey
objective investigate key stakeholders consider advantages opportunities improvement using lean thinking tools integrated project delivery process method detailed literature review followed case study lean project interviews members project leadership team focus groups integrated team design team online survey stakeholders conducted analysis statistical analysis thematic content analysis used analyze data followed plus delta analysis results learning large implicit benefit lean currently captured success metric mock successful lean strategy although collaborative project level influence different stakeholder groups perceived different different stakeholders overall lean rated better traditional design bid build methods opportunities improvement reported increase accurate cost estimating efficient use time perception imbalance control influence need facilitation represents different points view conclusion lean tools method preferred traditional design bid build methods perception different stakeholders varies work needs done allow truly shared decision making model learning identified one biggest advantages
series bearing capacity tests conducted loaded model surface shallow strip resting close reinforced finite sand slopes investigate ultimate loads failure surfaces load displacement curves rotation etc experimental set used run tests consists tank model sand loading mechanism single woven geotextile strip sheet placed base depth half width ultimate loads decreased increasing decrease due combination slope use geotextile reinforcement increased ultimate loads comparison unreinforced cases failure surfaces symmetrical primary failure surfaces developed slope side secondary failure surfaces developed side lengths failure surfaces decreased increasing prior failure always towards slope side degrees
work demonstrated successful construction metal free zero dimensional two dimensional carbon photocatalysts means electrostatic attraction experimentally found average diameter uniformly distributed surface using electron microscopy analysis sample content showed highest catalytic activity process visible simulated solar light process results evolution total amounts generated photocatalyst visible light activity found mol catalyst respectively values times higher respectively amounts generated using alone corresponding apparent quantum efficiency calculated furthermore sample demonstrated high stability durability four consecutive cycles significant decrease catalytic activity significant improvement using attributed synergistic interaction synergy allows effective migration electrons via contacted interfaces charge recombination confirmed measurements steady state time resolved analyses first principles density functional theory dft calculations consistent experimental results showed work function larger suggests efficient electrons conduction band recombination electron hole pairs significantly increased probability free charge carriers reducing overall study importance understanding charge carrier dynamics hybrid nanocomposites order enhance solar energy conversion
introduction given youth chronic pain frequently experience disruptions eating patterns place risk disordered eating purpose study examine clinical characteristics illness course adolescents chronic pain comorbid eating disorders methods using retrospective chart review adolescents chronic pain concurrent eating disorders identified adolescents compared age gender eating disorder symptom matched adolescents eating disorder without chronic pain results majority adolescents chronic pain eating disorder primary medical diagnosis abdominal pain followed autonomic dysfunction headache although chronic pain eating disorder symptoms developed onset pain reported eating disorder symptoms experienced chronic pain body mass index differ groups duration eating disorder symptoms significantly longer chronic pain group discussion despite comparable severity eating disorders longer periods patients chronic pain contribute poorer prognosis implications eating disorder conceptualization detection treatment discussed
last decade keyword search relational data attracted considerable attention possible approach face issue transform keyword queries one sql queries executed relational finding queries challenging task since information represent modeled across different tables attributes means needed identify schema elements data interest stored also find elements interconnected approaches proposed far provide monolithic solution work instead divide problem three steps first one driven users point view takes account user mind keyword queries second one driven database perspective considers data represented database schema finally third step combines two processes present theory behind approach implementation system called quest query generator structured sources deeply tested show efficiency effectiveness approach furthermore report outcomes number experimental results conducted elsevier ltd rights reserved
objectives characterize types external causes pediatric injury related visits emergency departments eds particular sports related injuries compare characteristics children non specifically differences rates race ethnicity health insurance methods stratified random sample survey eds national hospital ambulatory medical care survey including patients less years age national estimates pediatric obtained using assigned patient visit weights databases analyses measures association predictor variables patient health insurance characteristics whether child calculated using multivariate logistic regression analyses determine adjusted odds ratios confidence intervals results pediatric accounted million visits annually common diagnoses open wounds sprains strains fractures dislocations leading external causes sports related injuries accidental falls objects motor vehicle collisions children differed presented non many characteristics likely male older white race private insurance less likely asian hispanic ethnicity conclusions sports leading external causes pediatric eds united states different patterns according gender age race ethnicity insurance identification specific patterns injury necessary design effective prevention strategies
disc degeneration considered main cause many spinal disorders however underlying pathophysiology clearly understood recent studies indicate excessive mechanical loading serve major role initiation aim present study explore effect noninvasive cumulative axial loading lumbar spine using novel rabbit model rabbits experimental group placed individual tubes specifically designed force maintenance posture loaded heavy increase pressure lumbar spine imaging magnetic resonance imaging mri performed every weeks provide evidence disc degeneration end experiment animals sacrificed disc specimens harvested quantitative polymerase chain reaction histological analysis mri results revealed significant progressive reductions signal intensities lumbar experimental group compared control group throughout week study period expression level type collagen significantly increased expression levels type collagen significantly decreased experimental group compared control group histological examination revealed marked structural changes experimental group including like tissue accelerated fibrotic changes nucleus results present study indicate noninvasive cumulative axial load able induce accelerated degenerative changes rabbit lumbar provide useful information establishment novel animal model research humans
digital dead beat current controller voltage source converters presented paper control structure specified digital hardware description language synthesized deployed field programmable gate array chip updating negligible computation delay duty cycle twice switching period reference current error half modulation period controllers small signal bandwidth maximized addition due simple transient detection circuit large signal response delay reduced small fraction modulation period determined chosen current signal rate controller effectively support different voltage source inverter applications active filters power supplies microgrid distributed energy resource controllers converter applications including interface converters renewable energy sources laboratory battery electronic welding machines
microcontroller featuring voltage stacked memory logic presented involved connecting power domains memory logic series ground one power domain connected positive supply rail paper arm cortex powered powered since memory logic general draw different supply currents provided chip switched capacitor voltage regulator allow direct comparison voltage conventional single supply turned power memory logic turning voltage results power conversion efficiency active converter area reduced despite use smaller voltage reduces supply noise output voltage drops
objectivethe profession psychology challenging demanding field particularly newly registered psychologists entering workforce resilience important factor psychologists success therefore study aimed explore concept resilience among early career psychologists identifying factors strategies support resilience aspects work challenging early career study also explored universities help graduates resilient sample early career psychologists australia within various recruited participants asked five questions resilience contributing factors research team implemented qualitative method formulated interview schedule items determined literature interview data thematically analysed themes regarding workplace factors affect resilience concerned leadership organisational culture effort reward imbalance emotional labour strategies reported foster resilience early career psychologists included workload management professional development utilising peer networks reflection exercise regarding university training pathway support australian psychological society colleges important greater focus work supervision work integrated learning job relevant self care education teamwork critical thinking skills work readiness initiatives career management support experience working within multidisciplinary teams study shown important role universities play determining early career psychologists resilience findings new practical implications university curricula organisational practices
design methodology three stage cmos operating subthreshold region presented procedure focused development ultra low power amplifiers requiring low silicon area able drive high capacitive loads indeed following presented methodology designed cmos ota technology occupies powered supply exhibits gain able drive capacitive load thanks proposed methodology ota able provide khz unity gain bandwidth consuming even high load considered moreover slew rate enhancer circuit addition class output stage allows average slew rate higher load comparison prior art shows improvement factor figures merit higher
chronic one common intracranial worldwide high incidence general population however optimum treatment hole drainage without considering poor outcomes aged patients ambiguous prediction recurrence many sides recurrent analyzed new effective therapies needed poor prognosis surgery higher risk recurrence first line treatment patients high cholesterol coronary heart disease however still solely limited treatment diseases demonstrated improve due effect regulation angiogenesis inflammation review order provide potential new treatment summarize recent findings order try clarify mechanisms effect
leading following defined potent engaging excellence unpredictable ever changing noted processes forming essence leading following require commitment risk taking ambiguity others vigilance bond members society expectation nurses provide care individuals families communities nursing profession potential create meaning healthcare yet fully realized
background vast majority people living hiv aids reside low middle income countries particularly sub saharan africa including ethiopia despite huge number service users local area cognitive disorder among hiv patients extensively studied dearth knowledge subject objective study assess prevalence associated factors hiv associated neurocognitive disorder among people living hiv aids antiretroviral therapy art clinics methods institution based cross sectional study conducted april referral hospital health center international hiv dementia scale used screen hiv associated neurocognitive deficits logistic regression analysis used assess predictors neurocognitive disorders result risk hiv associated neurocognitive disorder count cells less aor formal education aor poor medication adherence aor older age aor found significantly associated hiv associated neurocognitive disorders conclusion risk hiv associated neurocognitive disorder found high among people living hiv aids emphasizes need regular cognitive screening early identification appropriate intervention elsevier ltd rights reserved
review empirical research effects media violence examines learned evidence extent evidence accepted face value article debates different data types different methodologies theoretical explanatory models directions effect value aggregated data sets limitations weaknesses identified relation various methodological approaches sources evidence featured academic discussions debates media policy content regulation although empirical research subject caution accepting conclusions harmful effects media violence instead calling targeted approach recognizes media consumers susceptible others media effects media violence vary risks represent potential triggers harmful reactions among media consumers
introduction overall goal alzheimers disease neuroimaging initiative validate biomarkers alzheimers disease clinical trials began august year renewal current study methods follow current additional subjects normal cognition mild cognitive impairment using innovative technologies tau imaging magnetic resonance imaging sequences connectivity analyses highly automated immunoassay platform mass spectroscopy approach cerebrospinal fluid biomarker analysis systems biology pathway approach used identify genetic factors subject selection enrichment amyloid positron emission tomography scanning standardized using method brain health registry help recruit subjects monitor subject cognition results multimodal analyses provide insight pathophysiology disease progression discussion aim inform treatment trials facilitate development disease modifying treatments alzheimers association published elsevier inc rights reserved
background children daily risk exposure common exposure pregnant women linked decreased birth weight abnormal reduction increased maternal reports signs pervasive developmental disorder aim current study examine long term effects prenatal exposure mice specific focus social repetitive behavior methods female mice treated vehicle gestational days oral gavage postnatal days early development ability assessed measuring neonatal offspring adulthood social behavior investigated using social preference social novelty social conditioned place preference tasks object recognition restricted interest measured repetitive novel object contact task also assessed order rule possibility administration induced alterations maternal care dams behavior evaluated via maternal retrieval task results treatment resulted delayed development neonatal mice treated dose exhibited reduced preference towards unfamiliar social preference test reduced social conditioned place preference task mice exposed dose showed enhanced restricted interest administration impair dams behavior cause memory recognition deficit observed object recognition task conclusions data indicate gestational exposure long term deleterious effects social behavior limits exploration novel objects
reproduction essential survival species influenced external factors smoking exposure chemotherapy chronic disorders obesity autoimmunity reproductive senescence menopause also dependent intrinsic genetic factors reproductive aging isolated overall aging process several studies strongly support link early age menopause mortality extreme form reproductive aging primary ovarian insufficiency prevalence ranging female population shown long overall health age menopause significant hereditary component population based genome wide association studies identified genomic loci associate age menopause loci dna damage response genes recent application whole exome sequencing carefully selected families also revealed significant contribution dna damage response genes inability repair dna damage somatic germ cells predisposing factor link reproductive overall aging subset individuals aim review characterize recent advances genetics link overall health
multiple substrate enzymes present particular challenge comes understanding activity complex system although single target easy model always present accurate representation enzyme presence multiple substrates simultaneously therefore need find better ways study enzymes complicated systems accurately describe interactions kinetic parameters review looks different methods studying multiple substrate enzymes explores options accurately describe enzymes activity within multi substrate systems identifying defining enzymatic activity help clear way using vitro systems accurately predicting behavior multi substrate enzymes vivo article part special issue entitled physiological enzymology protein functions published elsevier
social functioning routinely understood disrupted bpd features however little understanding bpd features bpd relevant traits impact social network characteristics time hypothesized bpd features negatively predict social network quality composition rejection sensitivity affect relations examine sample female college students recruited followed one month bpd features predicted lower ratings social network quality aspects network composition bpd features exerted indirect effect one week perceived levels conflict number partners network one month follow moderation analyses revealed bpd features predicted lower social network satisfaction support one month high impact satisfaction support low results indicate even non clinical levels bpd psychopathology related poor social network outcomes findings also highlight potential mechanism bpd features predict lower social support satisfaction potential risk factor higher conflict within social networks elsevier ltd rights reserved
paper two new voltage mode universal filters one input terminal five output terminals presented proposed circuits realize voltage mode notch filter transfer functions simultaneously using two plus type differential difference current two grounded capacitors three resistors moreover proposed circuits following attractive advantages realization standard filter functions circuit configuration employment grounded capacitors ideal integration iii low active passive sensitivities
aggregation neurotoxicity amyloid beta beta protein hallmark characteristic alzheimers disease study compared anti neuroprotective effects five synthetic compounds beta protein four possessed five ring scaffold two phenyl two one fused five ring selected thorough virtual screening zinc database molecular docking optimized structures used study beta binding characteristics predicted molecular docking strong binding bonding beta translated anti beta aggregation properties subsequent transmission electron microscopy tem used assess effects beta formation four compounds altered morphology long short loose structures assay beta kinetics demonstrated one compounds inhibited beta aggregation rat cells exposed beta alone combination compounds assess neuroprotective effects beta evoked loss neuronal cell viability significantly attenuated presence compounds compound toxic cells findings highlight beta anti neuroprotective propensity phenyl scaffold compound scaffold also possessed beta anti aggregation properties also demonstrated significant intrinsic neurotoxicity overall predictive efficacy silico methods enables identification novel act inhibitors beta aggregation neurotoxicity provide platform development novel alzheimers crown copyright published elsevier masson sas rights reserved
water scarcity current problem many urban areas mediterranean region due increasing water demand related population growth expansion urban areas climate change pressure water resources rainwater harvesting rwh effective alternative water supply solution face water scarcity recently become particularly important option arid semi arid areas mostly many benefits relative low costs present study aims analyse reliability rwh system installed supply water toilet flushing purpose reference single family house residential area southern italy historical water consumption data analysed obtain flushing water demand pattern water balance simulation rainwater storage tank performed yield algorithm used define tank release rule models performance evaluated using data different sites located throughout territory regional analysis provided results practical applications identification optimal rainwater tank size annual system reliability curves function mean annual precipitation uncertainty related regional model predictions also assessed results showed rwh systems provide environmental economic advantages traditional water supply methods particular regional analysis identified areas application system effective authors published elsevier ltd open access article license
context doubly fed induction generator connected utility grid unbalanced voltage conditions controller design needs ensure additional challenges restricting total harmonic distortion thd grid current minimizing generated power torque link voltage etc apart facilitating generator power control study negative sequence compensation scheme current investigated reference currents modified include negative sequence compensating component current rotor side converter employed compensate current thereby minimizing ripple power torque grid side converter used maintain unity power factor constant link voltage revealed controlling current single control target enables simultaneous reduction torque power link voltage also minimizes currents effectiveness scheme validated detailed analysis numerical simulations practical wind generation system experimental results test setup typical experimental results laboratory test setup show improved performance
database one biggest issues data security absence information drives business applications lost business procedures cope order track operations actors operations time need historical data temporary database legitimate exchange times two important time temporary database paper show methods handle database business exchange operations accurate times operations strategies separated two sets utilizing relational databases utilizing semi structured information
study found ethyl acetate soluble fraction rich source antioxidant due high total phenolic contents significant antioxidant activity ten phenolic compounds isolated plant acid acid methyl ester acid carbonyl ethyl ester beta bis one addition compounds possessed potent strong free radical scavenging activity compounds powerful activity showed higher content implying important roles antioxidant activity flower study suggested components flower possessed good antioxidant capacities species used prevention diseases related oxidant products human metabolism
power gas used store electricity whilst converting energy vector gas economically viable systems require cheap electricity cheap concentrated source biogas produced anaerobic digestion typically comprises methane system conventional system using hydrogen derived wind electricity react increases methane output potential production biogas ireland associated typical wet substrates assessed times greater required potential level electricity wind energy ireland assessed thus limited levels electricity rather biogas systems shown electricity used produce biogas system affect savings cost hydrogen assessed sic renewable methane price electricity sic leads cost compressed renewable gas grass sic drops sic electricity sic elsevier ltd rights reserved
paper examines ideological taken place labour five national assembly held parties found success managed combine effective leadership coherent programme strong sense identity however leave june dealt parties poor hand speaking interests find common cause working together also take forward progressive constitutional direction
patients thyroid cancer evolve current therapies however patients present recurrent disease eventually die anti inflammatory immunosuppressive cytokine contribute immune escape neoplastic cells aimed investigate molecular marker improve clinical management patients thyroid cancer retrospectively studied patients follicular cell derived thyroid cancer attended institution including classic thyroid carcinomas follicular variant thyroid carcinomas poorly differentiated thyroid carcinomas follicular thyroid carcinomas patients treated according current guidelines followed months additionally studied samples non malignant tissues investigated expression tumor cells quantitative methods malignant tissues presented higher positivity non malignant samples tumors invasion diagnosis presented higher levels positivity tumors without invasion observed positive correlation tumor size positivity correlation coefficient patients positivity median presented lower relapse free survival rate compared patients whose tumors presented positivity median suggest simple analysis help selecting patients benefit intensive approach
polymorphism opioid receptor gene investigated role sensitivity social contexts evidence suggests allele polymorphism associated higher levels sensitivity study tested main effects polymorphism interaction self report measure childhood adversity index negative environment outcomes several personality measures relevant social connection significant interactions obtained negative impact childhood adversity personality greater among carriers among measures interdependence anger hostility authentic life engagement index mostly negative feelings ones world view findings support role sensitivity negative environments limitations noted including lack measure advantageous social environment assess sensitivity positive social contexts
article propagation collision vector solitons investigated coupled variable coefficient nonlinear schrodinger equations describe amplification attenuation second pulses inhomogeneous optical fibre different frequencies basis lax pair many conservation laws obtained constraint among variable coefficients group velocity dispersion nonlinearity fibre gain loss two mixed type bright dark bright dark vector one two soliton solutions derived via hirota method symbolic computation influence variable coefficients nonlinearity vector soliton amplitudes velocities analysed asymptotic graphic analysis bound states elastic collisions vector two solitons investigated elastic also collision bright dark vector two solitons occur whereas collision bright dark vector two solitons always elastic bound states nonlinearity affect types nonlinearity constants collision period decreases increases independent nonlinearity
cellular membranes display diversity functions conferred unique composition organization proteins lipids one important aspect lipid organization asymmetric distribution across plasma membrane unequal distribution key creates physical surface tension used membrane like chemical gradient used biochemical signals type type atpase atpase family principle transporters used set repair gradient asymmetric organization membranes encoded substrate specificity enzymes thus understanding mechanisms atpase substrate specificity help reveal role membrane organization cell biology decoding structural determinants substrate specificity provides investigators opportunity tune specificity explore role particular substrates atpase cellular functions work reviews role membrane biology presents current understanding atpase substrate specificity discusses fundamental aspects atpase enzymology used enhance knowledge cellular membrane biology
investigated efficacy tolerability fixed dose children newly diagnosed idiopathic overactive bladder oab total children male female patients aged years mean age range newly diagnosed oab january september prospectively evaluated open label protocol patients treated fixed dose daily least weeks efficacy tolerability evaluated weeks initiation treatment mean voiding frequency daytime decreased times week treatment mean total oab symptom score decreased week treatment urgency urgency urinary incontinence domains significantly improved week treatment complete resolution urgency occurred patients percentage children among urgent patients decreased according day voiding diaries average bladder capacity increased drug induced adverse effects aes reported patients results indicate fixed dose effective oab symptoms tolerability acceptable without significant aes children oab
equilibrium reconstruction consists identifying experimental measurements distribution plasma current density satisfies pressure balance constraint numerous methods exist solve equation describing equilibrium plasma confined magnetic field research reviewed six techniques determination plasma position effects superconducting coils chamber optical flux loops magnetic probes moments techniques two methods based vertical field coil characteristics analytical solution equation first method image processing technique used output signal camera plasma emission intensity profile plasma position obtained compare plasma position obtained using method flux loop method magnetic probe method moments method analytical solution equation sensor less method based vertical field coil characteristics also results compared discussed hydrogen energy publications llc published elsevier ltd rights reserved
several noise level estimation algorithms developed use image processing computer graphics generally exhibit good performance however certain special types noisy images algorithms suitable particularly still challenge use algorithms estimate noise levels complex images original scenes similarly difficult apply conventional noise level estimation algorithms images rendered monte carlo method owing spatial variation noise images paper proposes novel noise level estimation method based histogram modification used accurate estimation noise levels complex images rendered images proposed method good performance simple implement efficiently used various image based graphic applications ranging smartphone camera noise removal game background
introduce heuristic called pcs alternative account various phenomena pcs give rise expectation attributes correlated based solely attribute base rates attributes encountered frequently attributes encountered rarely perceived correlated differences information densities typical many targets including self others group groups majority minority groups evidence reviewed pcs underlying correlations confirmation biases gender stereotypes paradox procedures used implicit stereotype measurement pcs shown predict specific patterns self enhancement self effects intergroup contact group biases readiness infer stereotypes aggregated big data although pcs lead seriously expectations afford efficient possibly adaptive inference strategy
materials engineering studies railway company responsible technical equipment interest basic mechanisms mechanical strength fracture metallic materials led development basic concepts papers published laid technique changed royal industrial academy designated materials testing laboratory technical university guidance institution acquired excellent reputation relevant areas german industry forming nucleus federal institute materials research testing developed equipment many different areas mechanical testing metallic materials paper characterization wear behavior materials viscosity overwhelming contribution materials engineering recognized early constituent resulting quenching iso designated value obtained instrumented method hardness elsevier ltd rights reserved
disposal olive shallow unprotected evaporation ponds common low cost management practice followed mediterranean countries far fate potential soil pollutants areas located near evaporation ponds adequately documented study investigates extent long term disposal evaporation ponds affect soil properties area located outside evaporation pond assesses fate pollution loads four soil profiles situated outside around slope side disposal area results showed considerable changes concentration soil site soil profiles due subsurface transport addition excessive concentrations recorded liquid samples taken inside bottom soil profiles concluded unprotected evaporation ponds located light texture soils pose serious threat favour soil water pollution
purpose purpose paper investigate newtonian heating slip effect mixed convective flow near point porous medium thermal radiation presence heat generation absorption chemical reaction design methodology approach governing nonlinear coupled equations converted ordinary differential equations similarity transformation equations solved numerically using method technique analytically using analysis method findings effects different parameters fluid flow heat transfer investigated found velocity temperature profiles increase increase number velocity concentration profiles increase decreasing chemical reaction parameter practical implications paper helpful engineers scientists field thermal manufacturing engineering originality value two dimensional boundary layer flow vertical plate slip convective boundary conditions near point analysed presence magnetic field radiation heat generation absorption paper helpful engineers scientists field thermal manufacturing engineering
substrate biological activity cells kidneys evolved early stage vertebrate phylogeny angiotensin molecules identified representative species vertebrate classes although variation occurs amino acids positions variations also evolved amino acid positions fish angiotensin receptors identified molecularly characterized vertebrates also various forms bypass traditional angiotensin system ras cascades large peptide substrates particularly tissues present nonetheless important functions ras maintain blood pressure blood volume homeostasis ion fluid balance via kidney central mechanisms stimulation cell growth possibly via action molecular biology ras receptors intensive research foci review provides overview phylogenetic appearance structure biochemistry ras cascade properties angiotensin receptors comparative viewpoints functions regulation ras vertebrates discussions focus fundamental functions ras conserved throughout phylogenetic advancement physiological implications significance examining biological history ras help analyze complex ras systems mammals furthermore suitable models answering specific questions often found primitive animals
diesel exhaust known induce tumours animals compounds found diesel exhaust particularly powerful recently showed vivo rats forming specific dna derived study panel genetically engineered chinese cell lines expressing various human cytochrome cyp enzymes human nadph cyp used identify cyp enzymes involved metabolic activation analyzed formation specific dna exposing cells similar pattern total four distinct dna found cells identical detected previously dna rats treated vivo total levels ranged using per nucleotides using enrichment comparison dna binding different derived cells revealed human involved metabolic activation furthermore dose dependent high levels detected exposure exhibits high activities results suggest major pathway human moreover acetylation initially formed hydroxy intermediates contribute high potential elsevier ireland ltd rights reserved
type eds increased prevalence gastrointestinal symptoms particularly reflux eds associated psychopathology chronic pain associated symptoms association symptoms eds non patient population effect mentioned factors never studied cross sectional study questionnaire used screen university students clinical examination established diagnosis eds validated questionnaires assessed somatic pain autonomic symptoms psychopathology quality life qol compared students without eds logistic regression analysis examined associations eds symptoms variables key students screened included eds female non eds female compared non eds students eds students likely multiple symptoms particularly early greater autonomic association eds symptoms dependent autonomic factors independent pain psychopathology pain related qol scores reduced eds group conclusions previously described association eds pain autonomic symptoms patients also present non patient groups future studies necessary explore etiological role connective tissue extra intestinal symptoms
stimulated like cytoskeletal effector proteins implicated regulating cell morphology adhesion migration various cell types however role proteins cell motility adhesion vivo trafficking remains poorly understood study identifies specific role cell trafficking demonstrate selectively required activated cell trafficking required normal cell development naive cell trafficking lymph nodes spleen using multiple sclerosis show impairment trafficking deficient activated cells inflamed central nervous system mice experimental autoimmune encephalomyelitis additionally found defect trafficking double knockout cells inflamed skin secondary lymphoid organs deletion resulted impairment alpha integrin expression function unexpectedly cells exhibit alterations shear resistant adhesion primary endothelial cells physiologic shear forces instead deletion impaired cell furthermore cell became equivalent control cells upon alpha integrin blockade overall selectively mediate activated cell trafficking promoting step migration alpha integrin dependent manner
analytical calculation methods major components synchronous inductance tooth coil permanent magnet synchronous machines paper inductance estimation different tooth coil machine compared one traditional rotating field winding machine accuracy analytical torque calculation highly depends estimated synchronous inductance despite powerful finite element method fem tools accurate fast analytical method required early design stage find initial machine design structure desired performance results analytical inductance calculation verified assessed terms accuracy fem simulation results prototype measurement results
water two important types interactions near biomolecules forms ordered around exposed hydrophobic regions participates hydrogen bonds surface polar groups types interaction critical structure function explicitly including appropriate number solvent molecules makes many applications computationally intractable number implicit solvent models developed address problem many treat two effects separately describe new model capture polar effects called solvent hydrogen bond occlusion model aims directly evaluate energetic penalty associated discrete first water molecules near solute polar group incorporated energy function find scoring protein structures provides superior performance loop modeling virtual screening protein structure prediction benchmarks improvements stem fact accurately identifies polar groups participate hydrogen bonds either solvent solute atoms polar groups expect future enable higher resolution predictions variety molecular modeling applications wiley periodicals inc
present randomized double blind placebo active drug controlled crossover study assessed residual active control placebo taken nocturnal patients sleep maintenance insomnia twenty two healthy sleep maintenance men mean age received placebo experimental hours two consecutive three conditions residual measured sleep latency testing digit symbol substitution symbol subjective sleepiness visual analog scale twice morning differ placebo measure residual showed significant measures residual effects detected hours ingestion middle night sleep maintenance
american girl multi product brand discourses gendered empowerment education previous scholarship american girl encourages normative gender roles limited notions diversity scholars knowledge discussed disability relation brand article explores representation disability american girl contemporary line analysis books unlike issues gender race class appear central american girls contemporary disability brand representation disability supplementary prime example explicitly targeted girls
violence children human rights problem across gender race geographical religious socio economic status cultural boundaries risk violence towards disabled children lifetime three four times greater towards non disabled children starts early childhood severe linked structures society violence individuals institutional practices part disabled childrens everyday life violence often related individual impairment recognised professionals victims presenting disabled womens reflections childhood violence help seeking responses disclosure article seeks raise awareness violence towards disabled girls need recognised serious child protection issue included official definitions child abuse
analyse velocity fluctuations inside coherent generated result inverse cascade two dimensional turbulence finite box demonstrated vol universal velocity profile established vol corresponds passive regime flow fluctuations property enables one calculate correlation functions velocity fluctuations universal region present results calculations demonstrate non trivial scaling structure function addition calculations reveal strong anisotropy structure function
background testosterone deficiency represents significant health risk factor men importance far underestimated besides physiological age related reduction acquired testosterone deficiency also occur testosterone deficiency possible result commonly occurring diseases basis development different diseases scope present investigation measurement serum testosterone levels different age groups materials methods serum testosterone levels determined samples healthy men laboratory colleagues routine conditions frequency testosterone deficiency calculated different age groups compared using spss software results low testosterone levels found subjects testosterone level lower decreased testosterone levels associated age addition proportion men decreased serum testosterone levels comparable age groups average serum testosterone level decreased slightly age groups period conclusions data reveal high rates testosterone deficiency men independent patient age decreased serum testosterone levels consequence several diseases involved pathogenesis diseases strongly recommended serum testosterone measurement included diagnostic especially symptoms loss erectile dysfunction lack concentration depression irritability sleep disturbance present
moderate doses drugs known enhance memory encoding consolidation effects memory retrieval explored depth laboratory animals seem improve retrieval emotional memories comparable studies carried humans present study examined effects amp retrieval emotional stimuli healthy young adults using doses enhanced memory formation administered encoding previous study sessions healthy volunteers received doses amp placebo order double blind conditions session first viewed emotional pictures words drug free state days later memory tested hour amp placebo administration affect number emotional stimuli remembered doses increased recall false recognition also increased number positively rated picture descriptions words generated free recall data provide first evidence therapeutic range doses drugs increase memory retrieval errors ability amp positively bias prior events contribute potential abuse
background question whether even chain fatty acids converted glucose long standing tradition biochemistry since shunt absent mammals question considered solved particular relevance understanding metabolic state regions due high fat content traditional diet containing negligible amounts carbohydrates methods results using silico approach discovered several hitherto unknown routes human metabolism allow conversion even chain fatty acids carbohydrates humans pathways proceed via intermediate produce precursor pyruvate pathways make contribution glucose production times limited carbohydrate supply found capacity limited due high demand reducing equivalents degradation considering traditional diet regions detected pathways important order improve carbohydrate supply moreover reduce amount protein needs used conclusion summary study sheds new light understanding metabolic state regions traditional diet moreover provide avenue new analyses reveal humans adapted practically carbohydrate free diet
implicated genetic risk factor bipolar disorder however resulting pathophysiological treatment implications remain elusive preclinical systems biological approach aimed characterize behavioral proteomic effects chronic mood treatment mice psychiatric related behavior evaluated novelty suppressed feeding paradigm elevated plus maze passive avoidance task tandem mass spectrometry employed hippocampal proteome profiling functional enrichment approach based protein protein interactions performed outline biological processes hippocampus affected lithium treatment proteomic abundance changes detected highlighted ppi network modelling followed targeted selected reaction monitoring increased psychiatric related behavior mice ameliorated lithium assessments followed modular ppi clustering functional annotation enrichment pointed towards related axonal transport glutamate signaling mediators pathophysiology lithium treatment validated hypothesis confirmed abundance changes interaction partners propose psychiatric related behavior mice connected disturbance system resulting dysfunction neuronal ion channel glutamate receptor transport lithium molecular signature suggesting promotion transport part mechanism action ameliorating related psychiatric related behavior elsevier rights reserved
computer graphics mass spring model used obtain fast visual results physical simulations disadvantage method obtain accurate result difficulty define parameters mass spring model different works results carried define model parameters field researchers used optimization technique based meta heuristic method applied fabric properties fast test determine model parameters far research done using combination two mentioned methods recover mass spring parameters therefore purpose paper determine parameters mass spring model applying particle swarm optimization techniques fast test point effective properties fabric including shear bending properties measured using fast system order reduce error value simulated actual fabric behavior parameters mass spring model super elasticity rate mesh topology natural length spring optimized applying particle swarm optimization pso pso parameters specified using design experiment finally fabrics simulated situations compared actual result validate model parameters results show optimized model able predict behavior fabric error value percent compared real result
considered one natural hazards responsible damage assets infrastructures many situations collection field data remote places difficult due area paper examines susceptibility ease geographical studies using image processing multivariate statistical tools reviewing digital images using remote sensing technique without physical survey considered different pixel resolutions report effectiveness using factor analysis principal component analysis linear discriminant analysis hybridization eight types databases heavy medium created modeling works carried pixel resolutions results indicate optimal heavy medium found ideal region performance different pixel resolutions compared using receiver operating characteristic roc curves average success found simple yet robust system holds great potential saving lives
background american among require surgery treatment end stage however prevalence breed remains unknown reviewed year medical records private veterinary clinics finland determine prevalence american compared english english american owner questionnaire designed identify potential risk factors end stage results medical records dogs prevalence highest confidence interval followed american english english mean number episodes ear diseased dogs number ear surgeries highest american owner questionnaires received american suffered dogs occurred without concurrent skin lesions displayed first signs year age dogs signs within month continued despite treatment required surgery operated dogs others due severe onset age year significantly increased risk end stage conclusions prevalence american finland higher previously reported highest prevalence found compared often recurrent frequently surgically managed american based questionnaire early onset year increased risk end stage american requires intensive approach first treatment prevention recurrence causes treatment breed warrant study
inspection analysis synthesis method multiphase switched current circuits using signal graph sfg techniques presented sfg derived transistor level method primarily useful hand analysis design small medium size circuits filters tables commonly used circuits corresponding circuits given make derivation easy fast overall discrete time transfer function also individual switching phases proposed method straightforward include non ideal effects finite output resistance mos transistors clock settling error method also useful tool synthesis new circuits shown every low sensitivity switched capacitor circuit mapped directly low sensitivity circuit corresponding topology examples transformed circuits given two new double sampling introduced john wiley sons ltd
many assessment measures validated one specific diagnostic population costly reduces clinical utility assessments child behavior inventory one popular measure designed assess disruptive behavior problems youth sound psychometric properties typically developing youth factor structure never examined children autism spectrum disorder asd therefore current study conducted comprehensive psychometric analysis children asd retrospective data nationally representative sample collected children asd ages years old four factor solution identified sample implications findings directions future research discussed
several studies reported previously acute myeloid leukemia aml express detected pcr northern blotting diagnostic utility expression aml using immunohistochemistry reported previously paraffin embedded tissue sections aml acute lymphoblastic leukemia normal bone marrow specimens anti terminus antibody aml cases demonstrated nuclear including bone marrow normal bone marrow specimens negative significant proportion aml expresses nuclear immunostaining finding described previously tumor small round cell tumor finding important correct interpretation immunohistochemical findings diagnosis small round cell tumors childhood especially cases deposits aml traditional myeloid markers negative
background dementia high burden patients informal caregivers society given changes care systems persons dementia live longer home however living home dementia good quality life easy achieve dementia often accompanied neuropsychiatric symptoms like depression anxiety negative impact quality life whereas cognitive deterioration hardly influenced possible reduce neuropsychiatric symptoms memories remain intact relatively long time dementia interventions promote feelings trust online life story book allows digitally share memories stories pictures video audio fragments main objective study effects neuropsychiatric symptoms study four secondary objectives study effectiveness intervention burden quality life primary informal caregiver provide preliminary health economic evaluation study time nursing home longer term effect provide process evaluation methods design randomized controlled trial individual randomization one two conditions conducted intervention online life story book control condition care usual participants persons early dementia primary caregivers intervention trained volunteer guides participants process together lives meetings within period weeks assess effects intervention primary outcome neuropsychiatric symptoms neuropsychiatric inventory assessed three time points intervention baseline months months post baseline discussion proven effective online life story book valuable addition existing provision care persons dementia informal caregivers
control systems course taught educational electric engineering programs world method used teaching course mainly mathematical representation software simulation systems behavior work author presents different approach based making hands experimental applications solution presented article based transfer function representation dynamic system order implement using electronic circuits combining presented method popular simulation software leads implementation practical effective laboratory classes course
responding narrative article commentary emergence child sexual abuse social issue los county based responses child sexual abuse los county experienced one social worker years discusses impact case identification intervention child sexual abuse cases tracks evolution changes took place southern california offers insight rationale denial child sexual abuse continues day
background like carcinoma rare high grade carcinoma resembles occur throughout body first reported bladder incidence bladder carcinomas due rare occurrence ideal treatment guidelines clearly defined methods pubmed search performed using two terms like carcinoma bladder review articles articles foreign languages expression studies studies performed bladder excluded report case bladder including treatment outcome performed systematic review available english literatures including present case identify factors affecting disease free survival results one hundred forty cases bladder analyzed mean age patients years ranging years males females pure occurs often followed mixed predominant ebv testing negative cases tested mean follow length cases months evidence disease died disease metastasis died without disease cases recurrence average months prognosis significantly favorable patients presenting pure predominant forms compared mixed type treatment significantly associated highest disease mortality lowest disease free survival alone compared multi modality treatment conclusion conclude best treatment modality associated highest disease free survival multi modal treatment including radical
background reversible cerebral syndrome syndrome characterized headache reversible arterial within months either spontaneous related trigger drugs including counter medicine common nevertheless sparse data association herbal supplements genesis unexplained methods describe case temporal association consumption diet pill composed green tea conjugated acid reviewed literature describing cases associated consumption herbal supplements plants results year old black woman presented emergency room headache less week beginning new herbal supplement weight loss purpose study revealed multiple arterial virtually intracranial reversed days later patient discharged minimal symptoms review identified previous reports herbal product related triggers conclusions different factors trigger besides case least products described associated disorders patients without clear cause clinicians aware possible role herbal supplements use systematically assessed large cohorts clarify association
study performed reveal factors associated dietary supplement use among japanese preschool children nationwide survey cross sectional internet survey conducted among mothers aged old preschool children japanese social research company february questionnaires assessed dietary supplement use lifestyle eating habits children mothers eating awareness among mothers mothers sources health information study employed logistic regression analysis evaluate association dietary supplement use variables dietary supplements used children children used supplements tended older age less likely get every morning likely eat frequently mothers used supplements children use supplements mothers level education household income associated supplement use among children likely mothers anxiety childrens health unhealthy eating habits striking effect supplement use among children however actual dietary balance daily rhythms child supplement users irregular unhealthy necessary give accurate information childrens dietary habits health address mothers anxiety
research indicates stereotypes example intersection stereotypes gender mental disorders result perceptions gendered mental disorders current research studies showed people view specific disorders masculine feminine masculine stereotype included antisocial personality disorder feminine stereotype included eating disorders personality disorder body disorder studies perception disorders masculine positively correlated stigma study showed positive correlation masculinity stigma also occurred examining specific symptoms rather full mental disorders findings provide evidence intersection stereotypes indicate novel factor understanding stigma
wastewater stabilization ponds common wastewater treatment remote canadian communities paper two geotextiles different mass unit areas examined potential upgrade existing summer conditions intended role geotextile provide additional treatment municipal wastewater column filtration experiments performed using municipal wastewater controlled laboratory environment either degrees degrees columns contained one two different nonwoven geotextiles gravel simulating contact wastewater weekly wastewater samples taken upstream downstream geotextile gravel filter analyzed suite water quality parameters hydraulic conductivity columns also measured weekly results showed possible accumulate biomass geotextile material month period temperatures corresponded log reductions hydraulic conductivity significant removal total suspended solids day biochemical oxygen demand total nitrogen total phosphorus observed however removal efficiencies parameters reduced lower temperature study demonstrates geotextiles used enhance performance systems operating climates elsevier ltd rights reserved
functional genomic analysis pathogen aspergillus identified multiple secondary metabolism genes upregulated host niche transcriptomic analyses infectious mutants lacking methyltransferase reveal differential expression elements often secondary metabolite gene clusters study investigate clinical environmental isolates structure distribution specific class long nuclear element line like loci genome probe stability response laboratory host imposed stresses silico analyses revealed class belongs line like elements southern blotting line specific probe clinical environmental isolates revealed high variability insertion pattern strains active transcription line like element type strain pcr one tested clinical isolates contain lines absolute requirement line mediated activities human infections finally found preliminary evidence association infection expansion element populations discrete genomes elsevier inc rights reserved
background individuals subjective perception increasingly recognized essential complement clinical symptomatology functional impairment childrens mental health measurement quality life qol potential give due weight childs perspective scope methodology aim critically review current evidence childhood mental disorders affect qol first major challenges research field outlined present systematic review qol children adolescents aged years formally diagnosed mental behavioural disorder compared healthy typically developing children children health conditions finally discuss limitations current evidence base future directions based results systematic review relevant literature findings conclusions systematic review identified eligible studies published year originated europe majority examined qol neurodevelopmental disorders including attention deficit hyperactivity disorder autism spectrum disorder motor disorders intellectual disability despite substantial heterogeneity studies demonstrate self reported global qol significantly reduced compared typical healthy controls across several disorders qol dimensions parents ratings average substantially lower casting validity proxy report studies large diagnostic groups depressive disorders anxiety disorders early onset schizophrenia eating disorders largely lacking conclude representative characterized normative clinical samples longitudinal qualitative designs needed clarify construct qol derive measures high ecological validity examine qol time attributable specific conditions contextual factors
assessed osteoporosis management patients admitted rehabilitation acute hip fracture open system community hospital institution fracture service pre surveyed patients months hip fracture subsequently program performed routine consultations recommended lab bone density testing bmd osteoporosis medication program outcomes assessed survey patients hip fracture pre population hip fracture changed calcium intake changed vitamin intake obtained bmd osteoporosis medication taken hip fracture post changed calcium intake changed vitamin intake obtained bmd post osteoporosis taken patients hip fracture program hip fracture patients improved non use osteoporosis medication
peculiar century gave birth many controversies since particular french language literature ecological claim often considered promotion paper challenge usual interpretation conclude source narrow sense reading paradigm shows stance different growth debate accurately linked option
paper unified solution method presented classical beam theory strength materials approach geometry material properties load system known related forces moments slopes deformations applying classical differential analysis addition equilibrium constitutive kinematic laws relations expressed unified formulation classical beam theory special case simple beams system four linear ordinary differential equations first order represents general mechanical behaviour straight beam equations solved using numerical differential method application advantages mathematical consistency conceptual simplicity numerical procedure simple gives clear understanding systematic way obtaining influence line bending moment shear force diagrams deformed shape beams geometric load discussed paper loads natural frequencies beam non type support conditions evaluated ease
many real world complex systems naturally map network data structures instead geometric spaces available information presence absence link two entities system enable data mining techniques solve problems network domain nodes need mapped geometric space propose mapping representing network node distances nodes space distance vectors space network position different nodes space encode network structure space considering continuous density field induced node density specific point summation density fields induced nodes drift node direction positive density gradient using iterative algorithm till node reaches local maximum due network structure captured space nodes drift region space belong communities original network use direction movement final position node important clues community membership assignment proposed compared state art community detection techniques two benchmark networks known communities using normalized mutual information criterion proposed algorithm outperformed methods significant margin moreover proposed algorithm also shown excellent performance many real world networks
background children always egg allergies early childhood egg less egg whites performed oral food challenge heated egg slightly contaminated egg white infants allergic egg hypothesized results predict egg natural course methods retrospectively reviewed participants egg allergy underwent first months age participants passed first defined tolerant participants failed defined reactive participants passed underwent half heated whole egg participants passed defined heated egg tolerant participants failed underwent another least months later compared tolerance heated egg months first tolerant reactive participants univariate multivariate logistic regression analyses conducted results included participants median age months range months tolerant reactive months first tolerant reactive participants achieved heated egg tolerance univariate logistic regression analyses reactive participants crude odds ratio confidence intervals baseline egg white levels crude per ten fold increase greater odds persistent allergy egg months first multivariate logistic regression analysis adjustment baseline egg white reactive participants greater odds persistent allergy egg tolerant participants adjusted conclusions classifying infants allergic egg tolerant reactive groups useful determining prognosis
widely recognized public key playing important role providing security services majority crucial arithmetic operation modular composed series modular hence performance strongly depends efficient implementation operations paper presents bit bits technique efficient implementation modular modular multiplication involved evaluated help method techniques improves performance reducing frequency modular results shows technique able reduce frequency bit exponent reduction resulted increased throughput comparison cost extra area power consumption reduced thereby saving energy
background interleukin blocker superior adalimumab treating moderate severe psoriasis phase trial objectives sought compare efficacy safety adalimumab placebo patients psoriasis treated year methods patients randomized weeks every weeks placebo weeks weeks every weeks adalimumab week week every weeks week physician reported outcomes global assessment psoriasis area severity index patient reported outcomes dermatology life quality index psoriasis symptoms signs diary safety evaluated week results superior placebo week global assessment score minimal greater improvement score baseline also superior adalimumab global assessment week week week furthermore significantly improved patient reported outcomes week adverse event rates comparable treatments limitations analyses limited weeks conclusions demonstrated superior efficacy compared adalimumab tolerated patients psoriasis year
like factor member family zinc finger transcription factors first cloned using complementary dna polymerase chain reaction pcr techniques human vascular endothelial cells template addition known ubiquitous like factor widely expressed numerous human tissues low levels present study function migration transition emt associated tumor progression investigated human oral squamous cell carcinoma cells genes differentially expressed normal tissue identified gene expression database identified upregulation expression subcellular location analyzed using immunohistochemistry expression measured three cell lines two cell lines highest lowest expression selected analysis subsequently cells reduced expression cells overexpressing constructed transwell migration wound healing assays used analyze migration cells addition mrna protein expression levels emt markers cadherin cadherin vimentin detected using reverse transcription quantitative pcr western blotting overexpression validated using tissue immunohistochemistry identified moderate high cytoplasmic staining cells knockdown overexpression altered migration ability cells decreased increased significantly respectively expression cadherin cadherin vimentin markedly altered cells indicating changes emt status results present study suggest overexpression changes migratory behavior cells induces emt lymph node metastasis expression
higher education interdisciplinary gender studies centers traditional academic knowledge making possible apply gender perspective objects knowledge however suffer insufficient recognition weak brazilian academia paper focuses trajectories gender studies centers affiliated north northeast gender studies feminist network analysis based data narratives histories centers women personal institutional dimensions involvement feminist studies influenced personal professional lives many suffered prejudice discrimination gender practically continue within universities order sustain centers research supported
background novel intranasal spray formulation composed enhancing comprised beta composition allows rapidly absorbed systemic circulation exhibit pharmacokinetics comparable subcutaneously administered rapid rate absorption suggested important optimal efficacy objective study evaluate safety tolerability acute treatment episodic migraine without aura month period based incidence treatment emergent adverse events evaluation results clinical laboratory tests vital signs physical examination methods multi center open label repeat dose safety study adults episodic migraine without aura subjects diagnosed migraine without aura according criteria set forth international classification headache disorders edition experienced attacks per month fewer headache days per month least headache free hours attacks used treat migraine attacks acutely course months results total subjects enrolled subjects used least dose study medication safety subjects completed month study total migraine attacks reported doses administered mean per subject monthly use doses adverse events expected administered compounds new safety signals emerged application site pain commonly reported treatment emergent adverse events months respectively treatment emergent adverse events mild serious adverse events considered unrelated study medication early discontinuation rate month treatment period conclusion shown tolerated used months treat episodic migraine acutely
aim study assess indirect costs health related quality life clinical characteristics patients psoriatic arthritis psa measured using psa disease activity index poland additionally aimed investigate association activity utility psa affected patients productivity loss polish setting questionnaire survey conducted assess disease activity productivity loss paper version questionnaire used assess productivity loss quality life indirect costs assessed human capital approach employing gross domestic product per capita gross value added gross income per worker poland expressed polish correlation presented using spearman correlation coefficient analysis performed basis full questionnaires collected observed mean utility value mean number days work days per month mean job productivity loss average monthly indirect costs per patient sic calculated using sic calculated using sic calculated using psa reduces patients quality life productivity loss associated total indirect costs negatively correlated utility greater disease activity lower utility greater indirect costs
european guidelines cardiovascular prevention recommend combining population high risk strategies lifestyle changes cornerstone prevention propose score function quantify cardiovascular risk guidelines highlight disease specific interventions conditions women young people ethnic minorities screening subclinical atherosclerosis noninvasive imaging techniques recommended guidelines distinguish four risk levels high high moderate low therapeutic objectives lipid control according risk diabetes mellitus confers high risk except subjects type diabetes less years evolution without risk factors complications type diabetes short evolution without complications decision start pharmacological treatment arterial hypertension depend blood pressure level cardiovascular risk taking account lesion target organs guidelines recommend antiplatelet drugs primary prevention increased bleeding risk low adherence medication requires simplified therapeutic regimes identify combat causes guidelines highlight responsibility health professionals take active role evidence based interventions population level propose effective interventions individual population level promote healthy diet practice physical activity cessation smoking protection alcohol abuse published elsevier espana slu behalf
climate models predict increased frequency intensity storm events unclear extreme precipitation events influence dynamics soil fluxes multiple greenhouse gases intact soil depth temperate watershed region two forest soils two soils wetland bank exposed experimental water pulses periods drying forcing soils towards extreme wet conditions controlled temperature automated measurements hourly resolution soil fluxes coupled chemistry analyses polymerase chain reaction gradient gel electrophoresis characterize changes microbial community structure automated measurements quantified unexpected increases emissions wetland forest soils following pulse events soil produced highest soil emissions wetland soil produced highest emissions forest soils produced highest emissions experiment using carbon dioxide three determined soil contributed year global warming potential forest soils contributed year result large emissions results provide insights influence extreme wet conditions chemistry factors controlling soil fluxes finally study addresses need test thresholds responses ecosystem functions climate
present investigation carried examine incidence pattern injuries adolescent athletes youth sports academy injury data prospectively collected athletes seasons total injuries identified time loss injuries overall injury incidence confidence interval incidence time loss injuries incidence growth conditions incidence serious injuries per exposure prevalence overuse injuries growth conditions represented injuries involved lower extremities foot ankle predominant injured body parts knee injuries mostly overuse whereas foot ankle injuries resulted acute mechanism minor moderate injuries accounted muscle tendon injuries accounted injuries comparing groups sport highest injury incidence injuries per athlete higher exposure associated greater overuse relative risk conclusion results study identified high incidence injuries youth sports population striking prevalence overuse injuries suggests need injury prevention protocols adolescent highly trained athletes
important antifungal antibiotic binds extracts fungal membranes previous work two derivatives improved pharmacological activities another derivative showed antifungal activity produced mutant strain gene furthermore inactivation domain resulted specific accumulation undesired metabolite suggesting improvement corresponding activity reduce eliminate accumulation accordingly within fully active predicted mutant able produce accumulated high yields moreover effect flanking linker regions domain evaluated found retention linker regions critical hybrid subsequently high yield production obtained overexpressing gene partner disrupting gene respectively knowledge first report elimination undesired metabolite along desired product improving catalytic efficiency domain using domain technology
transfer trained detector target scenarios important topic long time field computer vision unfortunately existing transfer methods need keep source samples label target samples detection phase therefore difficult apply real applications problem propose framework consists controlled convolutional neural network modulating neural network parameters last layer classifier dynamically adjusted target sample adaptively generates classifier contributions include first detector based unsupervised transfer method suitable real applications new scheme dynamically adjusting classifier new object function experimental results confirm method achieve state art results two datasets spie
improve education regarding sustainability green buildings designed people green building strategy game called deliver knowledge introduce applied technologies green buildings verify games learning effect conducted separate measurements using motivation model paper based exam among students architecture students divided experimental group played game control group underwent lecture based instruction results indicate game players stronger learning motivation attended lectures players learned game generally exhibited better learning effectiveness non players following cross validation discovered highly significant correlation learning effect players attention perception relevance confidence satisfaction game game system found attractive students implying effective instructional recreational material use green building education
objectives background parent knowledge child sleep influence parent efforts support healthy sleep children present study aimed describe parent knowledge child sleep hospital cohort potential correlates including barriers childrens information seeking child sleep demographics child age parent education household income methods total parents children aged years attending hospital inpatient day ward approached individually invited complete questionnaire questionnaire items modified measures published articles identified literature review developed clinical experience results parents average answered half knowledge questions accurately knowledge child sleep positively correlated education household income parents sought information books internet greater knowledge child sleep parents endorse sources information accuracy parent estimations childs sleep requirements varied within recommendations underestimated childs sleep requirements overestimated parents correctly estimated childs sleep requirements higher education income average likely parent younger children age years parents overestimated underestimated sleep requirements likely identify greater barriers childs conclusion overall knowledge child sleep sample poor consistent samples north american communities future studies examine whether knowledge child sleep barriers childrens related actual child sleep behaviors parent practices support children achieve healthy sleep elsevier rights reserved
introduction genomic transcriptomic profiling tumours understanding cancer however majority tumours possess multiple mutations determining oncogene even pathway target difficult proteomics emerging powerful approach identify functionally important pathways driving cancers targeted therapeutically areas covered authors provide technical overview mass spectrometry based approaches proteomic profiling review current emerging strategies available identification dysregulated networks pathways drug targets cancer cells key focus ability profile cancer potential applications mass spectrometry clinic also highlighted expert opinion addition proteomic information genomic platforms providing insight cancer cell biology application improved mass spectrometry technology methodology particular ability analyse post translational modifications providing complete picture dysregulated networks cancer novel therapeutic targets application proteomics discovery research continue rise improved workflow reproducibility required mass spectrometry enter routine clinical use
key element developing high performance smart material actuators design improved check valves high frequency fluid one method create valves fast frequency response replace single valves typically used systems array valves robust design presented overcome fatigue fabrication limitations observed previous approaches fluid structure interaction individual valve hydraulic fluid modeled using software results validated experimental testing array performance array smart material actuator compared larger single valve design array shown reliably flow high pressure high frequency environment smart material pump
understanding barriers seeking care pelvic floor disorders necessary sought assess familiarity pelvic floor disorders identify screening referral patterns among primary care providers institutional review board approved study distributed secure online server primary care providers within large healthcare system invited participate question survey regarding prevalence diagnosis treatment urinary incontinence overactive bladder oab syndrome pelvic organ demographic information collected descriptive statistics associations calculated total delivered responded response rate respondents distributed respect age years practice providers correctly estimated prevalence oab reported treating conditions respectively treatment failed however referral often majority reported screening believed prevalence rare referrals often male providers less likely screen female providers minority described familiar unaware providers within system primary care providers within large healthcare system familiar oab often prevalence nearly one fifth unaware within system educational outreach regarding pelvic floor disorders specialty likely improve patient access care
portable interface used program cluster nodes heterogeneous compute devices specification tightly binds workflow abstraction command specific device entire program best performance user find ideal device mapping command creation time effort requires thorough understanding match characteristics underlying device architectures kernels program paper propose add scheduling attributes context command objects intelligent runtime automatically perform ideal device mapping proposed extensions enable average focus algorithm design rather scheduling automatically gain performance without example design implement runtime task parallel workloads called efficiently schedules command across devices within implement several key optimizations reduce runtime overhead case studies include benchmark suite real world simulation show average users apply proposed extensions four source lines code existing applications order automatically benefit runtime optimizations also show always maps command optimal device set negligible runtime overhead
many report playing video games including violent content helps reduce stress however studies examined competitive cooperative video game play relate stress reduction current study employed design acutely stress participants assigning randomly play violent game either female results indicated stress levels declined time equal levels competitive cooperative game play participants competitive condition held slightly less positive impression following game play although players held generally positive impression overall elsevier ltd rights reserved
identification somatic mutations exon gene calr myeloproliferative neoplasms mpns december remarkable finding provided new molecular diagnostic marker particularly essential thrombocythemia primary myelofibrosis pmf second common altered gene two main types calr mutants type type evidence distinct clinical prognostic implications instances believed favorable outcome restricted type pmf using approaches recent publications supported classifying alternative mutants type like type like studies confirm results new considerations taken account molecular diagnosis mpns implies precise mutation characterization performed caution taken screening technique selection summarize current information regarding issues
look back skeletal radiology reveals number publications significantly advanced state knowledge diseases musculoskeletal system review summarizes content intriguing papers year
background patients aspirin exacerbated respiratory disease report type chest pain occurs rest responds corticosteroid therapy frequency associated coronary artery patients disease characterized blood respiratory tissue however unknown objective objective study understand cause chest pain described determine appropriate treatment methods chart review patients followed womens hospital performed patients reported type chest pain assessed presence cardiac risk factors response chest pain variety treatments two patients recurrent chest pain due suspected described detail cases also summarized results patients reviewed history chest pain concerning ischemia patients chest pain undergone aspirin desensitization initiated high dose aspirin therapy reported increase frequency severity chest pain high dose aspirin improvement aspirin discontinuation dose reduction many patients traditional cardiac risk factors none evidence coronary atherosclerosis almost significant chest pain improve typical treatments respond corticosteroid therapy conclusions although uncommon patients develop associated coronary artery occasionally worsened high dose aspirin patients present symptoms ischemic chest pain screened early treatment corticosteroids life saving american academy allergy asthma immunology
introduction containing compounds attractive chemical entities drug development compounds used treatment human disease studies suggest employ multiple forms activity however less known pharmacokinetic profile molecules areas covered herein compiled reported data presented accordance classical system identifying scope respective fields analysis suggests compounds several distinct ways move within human body specific structural features molecule account distinct pharmacokinetic profile insights useful designing desired effect expert opinion increasing knowledge pharmacokinetics providing broader understanding design new release systems potential drugs probable protein transporters related key roles physiological processes transporters involved sodium transport hormone release regulation cell cycle shared features among groups identified order apply insights design advantageous compounds
sample contains distribution nanoparticles various shapes sizes scanning electron microscopy image sample often captures fragment morphological variety present sample order quantitatively analyse sample using scanning electron microscope digital images particular derive numerical representations sample morphology image content assessed work present framework extracting morphological information contained scanning electron microscopy images using computer vision algorithms converting numerical particle descriptors explore concept image provide set protocols selecting optimal scanning electron microscopy images determining smallest representative image set morphological features demonstrate practical aspects methodology investigating phosphate calcium naturally occurring minerals wide range biomedical applications lay description typical sample contains distribution nanoparticles various shapes sizes single scanning electron microscopy sem image sample often captures fragment sample therefore fragment morphological variety present sample order obtain complete information true sample morphology one needs content series sem images article present framework extracting morphological information contained sem images using computer vision algorithms converting numerical particle descriptors representing particle morphology explore concept image provide set protocols selecting optimal sem images determining smallest representative image set morphological features demonstrate practical aspects methodology investigating sem images phosphate sample naturally occurring mineral wide range biomedical applications
study seeks identify suitable strategies promote effective learning construction management students boost instructors knowledge concerning choice appropriate strategies twenty two instructional strategies identified comprehensive literature review assessed based students perceptions determined questionnaire data returned valid questionnaires examined tested exploratory factor analysis structural equation model sem extracted five strategies web enhanced instructional strategy traditional learning instructional strategy activity based learning instructional strategy relational learning instructional strategy student centered learning instructional strategy results sem show student centered strategies strongest standardized regression path coefficient considered effective learning instructional strategies students based findings institution administrators channel available resources support strategies effective others similarly teachers adapt teaching styles strategies effective less effectiveness
software models defined code iteratively refined evolved due many reasons reflecting changes requirements modifying design enhance existing features understanding evolution model change detection approaches proposed models majority existing approaches successful detect atomic changes however composite changes difficult detect due several possible combinations atomic changes eventually hidden changes intermediate model versions longer available moreover multitude sequences used describe model evolution paper propose multi objective approach detect model changes sequence approach takes input exhaustive list possible types model operations initial model revised model generates output list applications representing good compromise following two objectives maximize similarity expected revised model generated model applying sequence initial model minimize number atomic changes used describe evolution fact minimizing number atomic changes important since easier designer understand analyze sequence composite model changes rather equivalent large list atomic changes due huge number possible sequences metaheuristic search method used explore space possible solutions end use non dominated sorting genetic algorithm find best trade two objectives paper reports results empirical study multi objective model changes detection technique applied various versions real world models taken open source projects one industrial project compared approach simple deterministic greedy algorithm multi objective particle swarm optimization existing mono objective changes detection approach two model changes detection tools based computational search statistical test results provide evidence support claim proposal enables generation changes detection solutions correctness higher average using variety real world scenarios
aims despite efficacy therapy urgency urgency incontinence daytime frequency value treatment nocturia remains unclear aim prospective observational study assess effect night time symptoms women overactive bladder oab including nocturia night time urgency incontinence nocturnal volume end points methods women idiopathic oab least one episode urgency urinary incontinence per day per nocturia episodes per night enrolled patients nocturnal excluded administered intra detrusor injections post void residual volumes checked participants completed day bladder diary health questionnaire weeks treatment reported efficacy treatment visual analog scale vas final follow visit results seventy six women completed study injections effective reduction nocturia episodes mean night time episodes compared baseline increase mean volume night time patients reported mean points improvement vas urinary retention required self observed three patients conclusions injection provides significant benefit night time symptoms oab patients results applicable women without nocturnal prove useful counseling patients risks benefits neurourol urodynam wiley periodicals inc
article reviews recent advances ftir spectroscopy areas related natural tissues cell biology update previously published review applications spectroscopic methods employed analysis biological molecules summarizes widely used peak frequencies assignments aim review update previously published spectral database help researchers defining chemical structure biological tissues introducing important peaks present natural tissues precisely accurately spite applying different methods seems considerable similarity defining peaks identical areas ftir spectra result believed preparing unique collection frequencies encountered ftir spectroscopic studies provide substantial help future studies article included recent studies reported since previous publication considerable assistance added value focusing research defining chemical pathway progression different diseases
aim proof concept study explore whether dna methylation first diagnosis associated response disease modifying drugs patients early rheumatoid arthritis patients methods dna methylation quantified lymphocytes treatment naive patients using treatment response determined months using european league response criteria results initial filtering identified phosphate differentially methylated responders conservative adjustment multiple testing six sites remained statistically significant four showed high sensitivity specificity response treatment moreover methylation two sites combination strongest factor associated response sensitivity specificity auc conclusion dna methylation diagnosis associated disease modifying drug treatment response early
introduction attention deficit hyperactivity disorder adhd one prevalent neuropsychiatric disorders childhood adolescence usually first choice drug however many patients respond also comorbid sleep mood anxiety disorders associated problems misuse dopamine inhibitor promising alternative reports positive outcomes adhd management adolescent adult populations study systematically reviews clinical trials subject methods using keywords attention deficit hyperactivity disorder adhd preliminary search pubmed databases yielded articles published english january six articles clinical trials involving children full articles also reviewed references interest results available open controlled randomized trials demonstrated efficacy improving adhd symptoms three head head trials found efficacy comparable however large double blind placebo controlled multicenter study found smaller effect sizes quantified using teacher parent ratings adhd symptoms terms tolerability head trial found headache observed frequently treated group group whereas frequency side effects differ significantly conclusion current findings interpreted caution limited database considered pharmacological management childhood randomized controlled trials larger sample sizes warranted also evidence benefits children comorbid adhd conduct substance use depressive disorders
children exposed early age gender class race related messages likely influential development childrens beliefs attitudes gender roles class racial groups although representations females minority children improved years stereotypical biased females racial minority groups remain using theoretical lens textual analysis conducted examine representation two current leading minority female characters childrens character stereotypes challenges traditional stereotypes role race gender class representations characters explored analysis
maize mosaic virus widespread pathogenic virus causes serious loss yield maize rna interference rnai triggered hairpin rna transcribed transgenic inverted repeat sequence effective way viruses plants study expression vector containing sense arm antisense arm separated intron maize actin gene constructed target protein protease gene used transform agrobacterium tumefaciens strain transformed agrobacterium strain used transform maize embryonic isolated immature embryos improved culture technique plants regenerated stringent selection certified positive pcr amplification positive plants grown produce offspring nine identified southern blotting transgene integrated one two copies resistance three lines evaluated field trial dual inoculation two environments found improved compared non transformed control disease indexes transgenic plant lines significantly different highly resistant control line viral titers inoculated plants detected double antibody sandwich enzyme linked immunosorbent assay elisa result resistance evaluated field trial addition root promoting powder showed significant improvement regenerated stronger generated better fibrous root system control improvement facilitate transgenic operation maize
purpose investigate change urinary urgency predictors urgency improvement laser prostate men benign prostatic hyperplasia materials methods retrospectively analyzed medical records patients treated preoperative urgency measuring point urinary sensation scale prostate cancer diagnosed prior history prostatic surgery moderate severe postoperative complications neurogenic causes excluded patients improved urgency antimuscarinic medication excluded divided patients groups based urgency symptoms months improved urgency improved urgency defined reduction points point urinary sensation scale preoperative clinical urodynamic factors perioperative factors compared groups results total patients included study voiding parameters patients improved significantly seventy one patients improved urgency show improvement history acute urinary retention residual associated postoperative urgency improvement univariate analysis multivariate analysis history independent factor affecting urgency improvement conclusions preoperative history influence change urgency surgery patients
background immune mediated diseases rheumatoid arthritis ankylosing spondylitis inflammatory bowel disease ibd commonly affect young adolescent females anti tumor necrosis factor alpha agents increasingly used treat conditions safety pregnancy remains unclear objectives evaluate risk pregnancy related outcomes patients various immune mediated diseases treated anti tnf alpha agents methods electronic databases searched studies assessing outcome pregnancy female patients various immune mediated diseases treated anti tnf alpha agents direct network meta analyses performed anti tnf alpha users non users general population results thirteen studies including ibd various immune mediated diseases identified among studies compared outcome anti tnf alpha users general population anti tnf alpha users non significant trend towards reduced rate live birth odds ratio confidence interval significantly increased risk preterm birth spontaneous abortion low birth weight compared general population risk anomalies elevated among studies compared outcome anti tnf alpha users non users significant differences rates live birth pregnancy related complications among studies compared outcome non anti tnf alpha users general population risk spontaneous abortion elevated significant differences rates live birth pregnancy related complications network meta analysis confirmed rank order outcomes general population non users users anti tnf alpha agents order based safety conclusions female patients immune mediated diseases treated anti tnf alpha agents significantly increased risks preterm birth spontaneous abortion low birth weight compared general population comparable outcomes non users results provide useful information female patients reproductive age raise awareness conditions facing among clinicians managing care elsevier ltd rights reserved
paper reports design implementation integrated operational amplifier bipolar sic operation positive feedback configuration opamp studied different feedback closed loop compensated amplifier comparator hysteresis trigger relaxation oscillator measurement results suggest stable closed loop opamp similar gain trigger constant threshold levels wide temperature range relaxation oscillator tested khz tested degrees degrees elsevier ltd rights reserved
membrane matrix metalloproteinase mmp implicated together tissue inhibitor matrix activation pro matrix metalloproteinase cell surface expressed cell surface either activated soluble form mmp mmp previously identified tissues fluid patients loose arthroplasty aim study examine tissues fluids patients loose arthroplasty tissues fluids patients disorders presence mmp investigate activation state possible role antibody mmp protein molecular mass similar detected western blotting samples tested representing soluble form mmp ascribed alternative splicing northern blotting showed one transcript various biochemical methods shown species occurs latent form bearing terminal additionally bound appeared bound via terminal domain site different active site cell elisa immunohistochemical analysis revealed besides fibroblasts cells inflammatory epithelial endothelial giant cancer cells express mmp plasma membrane taking account proteolytic abilities mmp latent mmp complex considered new interstitial however exact role production mechanism cell origin complex remain elucidated
enhancement total electron content storm days day values analysed different seasons solar activity conditions low latitude station period dependence enhancement storm time positive solar radio flux positive correlation observed winter negative correlation depletion storm time solar radio flux positive dependency observed summer intensity storm found negatively correlated enhancement storm time positive dependency shown winter negative depletion storm time shows dependency shows positive correlation summer considering dependence enhancement max positive correlation observed winter positive negative correlation depletion storm time max found positive summer similar correlation study carried time delay tau occurrence maximum enhancement depletion maximum minimum percentage probability range delta also analysed considering data elsevier ltd rights reserved
purpose implementation lean methodology pharmacy programs community teaching hospital described summary new regional medical center community teaching hospital southeastern north fully adopted lean culture given success lean strategies methodology used assist evaluation development pharmacy programs lean tools activities also incorporated requirements rotation learning activities majority lean events correspond required competency areas evaluating leadership management teaching education events included participation facilitation various lean problem solving communication tools application rules lean resulted enhanced management programs provides set tools quality improvement ensured regular communication direct involvement parties critical developing sustaining new improvements addition program enhancements lean methodology offers novel methods residents incorporated leadership activities conclusion incorporation lean methodology pharmacy programs translated variety realized potential benefits programs residents health system specific areas growth included quality improvement processes expansion leadership opportunities residents improved communication among program residents
commentary argues rather providing exhaustive review discuss selective sample empirical studies violent video game use corroborate claim systematic evidence link violent video game play aggression evaluating evidence authors biased picture current state knowledge media violence effects fail distinguish aggression violence everyday clinical forms aggression furthermore key constructs mediation moderation external validity methodologies used assess aggression media violence use paper moves debate backward rather forward falling behind existing meta analytic studies consider much wider balanced range studies
point cloud data important source modern day data acquisition processing techniques airborne laser scanning multi beam generate points simply area square size point clouds exceeding billion mark even small area need efficient storage management point clouds sometimes associated attributes constraints storing points currently possible confirmed initial implementations oracle spatial point cloud extension able analyse extract useful information point clouds need just points require surface defined points space different ways represent surfaces gis including grids boundary representations etc study investigate database solutions storage management massive classical face edge based compact star based data structures discussed length reference structure advantages limitations handling massive compared current solution simple feature main test dataset tin generated third national elevation model netherlands point density points used storing generated tin data structures tested generated tin models account geometry topology storage indexing loading time database study useful identifying limitations existing data structures storing massive required optimise structures managing massive database
human papillomavirus vaccine approved use food drug administration june vaccine routinely recommended administration women usa years old committee immunization practices previous studies suggest vaccine administration associated autoimmune diseases consequence epidemiological assessment vaccine adverse event reporting system database undertaken adverse event reports associated vaccines administered year old recipients listed residence specified female gender cases serious autoimmune adverse event outcomes odds ratio confidence interval rheumatoid arthritis thrombocytopenia systemic lupus erythematosus vasculitis cns demyelinating conditions ovarian damage irritable bowel syndrome significantly likely controls received vaccine median onset initial symptoms ranged days post vaccination cases outcome syndrome likely controls received vaccine addition cases known related outcome significantly likely controls received vaccine cases general health outcomes infection diarrhea pneumonia likely controls received vaccine confirmatory epidemiological studies databases undertaken long term clinical consequences hpv linked examined
dams significant impacts temperature processes streams areas also used viable tool restoring impaired systems dynamic nature dams influences vary difficult quantify begin understanding impacts dams mountain streams developed hydraulic models impacted reach includes eight dams non impacted reach compare hydraulic responses channel depth width velocity distributions also compared observations substrate size distributions different habitat units within reach results models indicated shifts channel hydraulics statistically significant increases depths decrease flow velocities impacted reach hydraulic adjustments result dams consistent observed changes increased variability spatial heterogeneity sediment size distributions application three different modelling approaches found relatively low number dams result significant changes channel hydraulics results provide preliminary information regarding number dams per unit stream length required begin meeting various restoration goals
cocaine users display preferences smaller immediate rewards larger delayed rewards delay proposed cocaine addiction recent evidence suggests system specifically alpha adrenergic receptor impacted chronic cocaine use also potentially involved neural mechanisms underlying hence investigated effects polymorphisms mrna expression levels cocaine users naive controls two hundred twenty three participants cocaine users naive healthy controls completed computerized paradigm genotyped three single nucleotide polymorphisms snps gene peripheral mrna expression quantified whole blood samples three snps near perfect linkage accordingly significant group genotype interactions found three revealing cocaine users controls carrying allele snp allele allele similarly high mrna expression levels significantly associated reduced tendency choose smaller immediate rewards larger delayed rewards cocaine users controls relationship cocaine use moderated snps peripheral gene expression propose involved deficits observed cocaine using individuals consequently pharmacological compounds targeting considered symptom specific treatment delay addiction
analytical solutions van der normal form granular media done study phase separation phenomenon using two different exact methods analysis discussed illustrate model equation auto backlund transformation presented via truncated expansion symbolic computation results show exact solutions model introduce solitary waves different types solutions hydrodynamic model van der equation exhibit behavior similar one observed molecular dynamic simulations two pairs shock waves appear move away giving rise dispersion properties relation group phase velocities model equation studied using plane wave assumption diagrams drawn illustrate physical properties exact solutions indicate stability bifurcation elsevier rights reserved
resilience related students academic success challenges associated students historically backgrounds non traditional students frequently reported resilience received lesser attention primary purpose study compare levels resilience traditional non traditional students first year students participated online mental health survey included standardised measure resilience demographic questions item exploring students perception non traditional results showed students considered non traditional life aspects including age employment parenting responsibility significantly higher resilience compared self identified traditional students however resilience levels students deemed non traditional domains household income cultural background differ significantly traditional students findings show life experiences commonly affiliated mature aged student including work contribute higher resilience implications relation practice future research discussed
analogue replace dna acts strong potential applications molecular biology cancer therapy ultraviolet irradiation investigated manifold accurate quantum chemistry calculations non dynamics simulations found irradiation bright state three main relaxation pathways principle possible relaxation back ground state crossing based accurate optimizations propose ground state relaxation predominant pathway gas phase employ different electronic structure methods assess suitability carry excited state dynamics simulations multi reference configuration interaction including single excitations used surface simulations compute dynamics mostly involves states article part issue theoretical computational studies non equilibrium non statistical dynamics gas phase phase interfaces
first using delphi method field literature research method builds manufacturing engineering enterprise standardized management index system second using ahp calculates index weights manufacturing engineering enterprise standardization management system third study constructs manufacturing engineering enterprise standardized management hierarchy model manufacturing engineering standardized management maturity model built last provides reference manufacturing engineering enterprise overall standardization management level enterprise improve overall standardized management level
technical writing functions mere summary situated beginning academic report writing considered important site promotes draws readers attention read paper often tend use evaluative language abstracts convey stance disciplinary knowledge making readers value study study investigates stance engagement readers abstracts consists corpus online abstracts chinese students departments electronic engineering computer engineering information technology manufacturing engineering engineering management hong kong university analysis texts based four parameters evaluation texts proposed namely good bad positive negative parameter certainty parameter importance parameter parameter findings show evaluative language signaling worth study certainty knowledge claim good bad parameter mostly used corpus study also discusses implications technical communication
buildings consume significant proportion worlds resources mostly form materials usage addition ongoing efforts focusing reducing operational energy consumption buildings embodied emissions buildings expected increase proportion future increasing focus placed embodied emissions buildings organizations construction industry face requirements report information regarding embodied emissions buildings however order obtain embodied emission buildings tremendous efforts placed process data intensive order overcome challenge technique proposed minimize efforts required practitioner obtain embodied carbon footprint proposed technique comprises probabilistic model emission factor estimators used estimate required embodied emissions based four projects presented case study proposed technique practitioner required manually match appropriate emission factors activity data data points contrast current traditional technique requires manual matching data points resultant deviation computed embodied carbon footprint proposed technique current technique elsevier ltd rights reserved
individuals autism spectrum disorder asd thought encounter planning difficulties experimental research regarding planning asd inconsistent means meta analysis planning studies combined sample size individuals without asd aim determine whether planning difficulties exist factors contribute planning problems evident individuals asd even taking publication bias account neither age task type reduced observed heterogeneity suggesting crucial moderators within current meta analysis however showed asd individuals encounter planning difficulties bias towards publishing positive findings strong conclusions regarding role potential moderators
aim study determine whether incidence pneumonia patients taking frequent compared taking atypical antipsychotics admission tertiary care medical center retrospective case matched study general medicine patients month period july july detailed electronic medical records analyzed explore association use two atypical antipsychotics incidence pneumonia patients group documented pneumonia compared group general population group compared untreated general population associated increased risk pneumonia odds ratio confidence interval however significant increase risk pneumonia associated use odds ratio confidence interval use associated increased risk pneumonia related immunologic factors side effects make aspiration likely although causative mechanisms require investigation findings suggest providers use added caution choosing candidates therapy
background daylight hours high latitude regions tend longer japan summer shorter japan winter example daylight hours london winter one third therefore study investigated compared seasonal changes mood behaviours japanese individuals living outside japan methods surveys conducted japanese residents summer winter countries southeast asia japan first summer winter general health questionnaire scores regional group analysed subsequently month wise differences mood behaviours compared across four geographical regions results summer winter scores participants living countries differed significantly seasonal differences observed residents japan southeast asia countries summer associated better mood activity winter linked lowered mood reduced activity conclusion results indicate japanese living countries high latitude regions experience seasonal fluctuations depressive symptoms linked drastic seasonal environmental changes observed month period mood behaviour declined winter improved summer therefore considering prevalence stressors differ home country necessary investigate effectiveness support systems help migrants adapt seasonal changes high latitude regions
paper serial parallel hybrid power system formed fuel cell auxiliary storage device asd current controlled converters responsible power management realized using digital signal controller dsc main energy management goal transfer energy sources asd load ensuring bus voltage regulation high power conversion efficiency addition safe reliable operation system achieved selected converter controller features voltage step step high efficiency regulation input output currents low ripple values ability change input output current regulation loop vice versa features allow positioned different system simplify design master control simulation experimental results validated bus
producing software systems achieve acceptable among multiple non functional properties remains significant engineering problem propose approach solving problem combines synthesis spaces design alternatives logical specifications dynamic analysis point resulting spaces hypothesize approach potential help engineers understand important among dynamically measurable properties system components meaningful scales within reach existing synthesis tools test hypothesis developed tools enable conducted set experiments domain relational databases object oriented data models several data models used approach empirically test accuracy published suite metrics predict based static schema structure alone results show exhaustive synthesis analysis provides superior view tradeoff spaces designs work creates path forward toward systems achieve significantly better among important system properties
introduction clinicians resilient likely provide patient centered care aimed enhance clinicians offering mindfulness based stress reduction course mindfulness stress management determine whether impacted subsequent medical longitudinal cohort study clinicians taught certified pre post online questionnaires assessed burnout depression stress mindfulness patients independently rated clinicians using communication rating scale clinical encounter clinician took course nine medical doctors consultations coded analyzed independent team using interaction analyses significant reductions stress burnout found increases mindfulness decrease stress correlated less attitudes less mindfulness decrease emotional correlated acting awareness less mindfulness patients perceptions clinical encounter suggested patient centered care improved decreased significantly associated subscale understanding patients experience illness time points doctors dominated exchange patient mindfulness direct positive impact clinicians clinicians experienced less patients reported better understood
background largely employed veterinary practices ensure wellness animals partially absorbed within gastrointestinal tract several tissues therefore potential toxicity relevant considering putative risk derived entry accumulation drug human pet food chain supply despite scientific literature highlights several dependent toxic effects human animal health molecular mechanisms toxicity still poorly understood methods evaluated dna damages epigenetic alterations quantitative reverse transcription polymerase chain reaction quantitative polymerase chain reaction chromatin immuno precipitation western blot analysis results observed human peripheral blood mononuclear cells pbmcs expressed dna damage features activation phosphorylation modifications histone lysine chromatin vitro exposure changes linked robust inflammatory response indicated increased expression interferon ifn gamma type superoxide dismutase discussion data reveal unexpected biological vitro activity able modify dna chromatin cultured human regard presence foods animal origin represent potential risk human animal health
mitochondrial diseases diverse group inherited acquired disorders result inadequate energy production caused genetic mutations acquired somatic mutations exposure toxins including prescription medications normal mitochondrial physiology responsible part aging process free radical production within mitochondria results lifetime burden oxidative damage dna especially mitochondrial dna turn replicate mutational burden future copies lipid membranes primary mitochondrial diseases caused mutations genes encode mitochondrial structural enzymatic proteins proteins required mitochondrial assembly maintenance number common adult associated defective mitochondrial energy production function including diabetes obesity hyperthyroidism hypothyroidism mitochondrial dysfunction demonstrated many neurodegenerative disorders including alzheimers disease parkinson disease amyotrophic lateral sclerosis cancers polymorphisms mitochondrial dna linked disease susceptibility including death sepsis survival head injury considerable overlap symptoms caused primary mitochondrial diseases illnesses affect mitochondrial function caused primary mutations disorders mimic mitochondrial diseases caused identified mutations evaluation disorders complex expensive without false negative false positive results physician common heritable mitochondrial disorders described literature overlooked many clinicians disorders general evaluation classic mitochondrial disorders become straightforward clinician recognized phenotype orders appropriate confirmatory testing however majority patients referred mitochondrial evaluation clear presentation allows rapid identification testing article provides introductory comments mitochondrial structure physiology genetics focus presentation evaluation adults mitochondrial symptoms primary mitochondrial disease
stress effects semiconductor devices gained significant attention semiconductor industry recent years numerical modeling often used powerful tool stress analysis semiconductor devices present model fast stress analysis bipolar junction transistors bipolar transistors devices possible speed simulation numerical model get results comparable simulation outcomes model consists complete numerical algorithm used stress analysis bipolar transistors plane existing simulators take time solve device equations throughout device contrast model optimizes solutions different regions development inclusion specific algorithms fractional starting point introduced depletion region speed process way faster computing time much higher accuracy reached time popular simulators using finite element methods naturally much slower especially high accuracy needed simulation results model match simulation results model developed commercial technology computer aided design tool validity model verified experimental results theoretical expectations copyright john wiley sons ltd
occurrence osteoporosis tuberculosis chronic infection rarely evaluated study found significantly higher incidence rates osteoporosis adjusted hazard ratio osteoporotic fracture tuberculosis patients matched cohorts suggest osteoporosis screening considered tuberculosis patients follow program aim study determine occurrence incident osteoporosis patients completed anti tuberculosis treatment chronic inflammatory disorders associated increased risk osteoporosis although infectious disease characterized systemic inflammatory responses impact active incident osteoporosis unclear used taiwan national health insurance research database investigate association history active incident osteoporosis osteoporotic fracture nationwide retrospective cohort study active patients age sex matched controls identified national health insurance research database taiwan occurrence incident osteoporosis osteoporotic fractures risk factors associated osteoporosis among patients matched controls analyzed observed incident osteoporosis patients matched controls incidence rate osteoporosis per person years significantly higher patients multivariate analysis independent risk factor osteoporosis independent factors associated osteoporosis older age female sex chronic obstructive pulmonary disease asthma lower income moreover demonstrated occurrence osteoporotic fracture significantly higher patients patients history active higher incidence rate osteoporosis osteoporotic fracture
background selective serotonin inhibitors serotonin inhibitors widely prescribed mood anxiety disorders however clear whether strongly associated cardiovascular cerebrovascular events methods propensity score matched population based cohort study started april march primary composite acute myocardial infarction ami stroke cardiovascular related hospitalization within year drug initiation component primary outcome death analyzed separately secondary analyses results total patients initiated treatment respectively propensity score matching higher risk observed primary outcome among users weighted hazards ratio confidence interval secondary analyses showed risk stroke higher among users weighted risk death higher among users without mood anxiety disorders weighted differences observed risk ami fatal stroke use conclusions new use associated higher risk stroke relative use investigation warranted regarding higher risk death observed subgroup analysis among incident users without mood anxiety disorders
previous studies demonstrated targeting bradykinin receptors promising strategy counteract cognitive impairment related aging alzheimers disease hippocampus critical cognition abnormalities brain region linked decline mental ability nevertheless impact bradykinin signaling hippocampal function unknown therefore sought determine role hippocampal bradykinin receptors cognitive decline middle aged rats twelve month old rats exhibited impaired ability acquire retrieve spatial information water maze task single intra hippocampal injection selective antagonist des bradykinin nmol selective antagonist nmol reversed spatial learning memory deficits animals however drugs affect cognitive function month old rats suggesting absence properties molecular biology analysis revealed regulation expression hippocampal sub region pre frontal cortex month old rats whereas changes expression observed middle aged rats findings provide new evidence inappropriate hippocampal expression activation exert critical role spatial learning memory deficits middle aged rats therefore selective antagonists especially orally active non peptide antagonists represent drugs potential interest counteract age related cognitive decline elsevier rights reserved
order help students industrial engineering learn definition industrial engineering choose directions paper review developing situation definition industrial engineering definition industrial engineering set course system industrial engineering based comprehension industrial engineering experience comes authors long term teaching practice finally definition industrial engineering described administrative skill system adopts engineering viewpoint plan form optimize various schemes social organization activities establish maintain improve various system social organization achieve operating targets social organization raise benefit efficiency course system include human machinery engineering manufacturing engineering administrative engineering information engineering specialized engineering
involves living organisms products degradation highly resistant plant originated polymer three dimensional network non units major repository aromatic chemical structures earth paramount significance removal owing potential application systems industrial production early reports illustrating discovery cloning fungi truly field enzymatic however enzymology bacterial hitherto poorly understood moreover degrading bacterial genes still unknown need exploration review deals current knowledge enzyme families produced fungi bacteria mechanisms action genetic regulation render attractive candidates biotechnological applications
present study examines moderating role self acceptance self esteem relation frustration intolerance beliefs psychological distress participants one hundred fifty student aged studying three universities institute information technology university management sciences university central pakistan completed demographic information sheet frustration discomfort scale self esteem scale society adolescent self image university press self acceptance questionnaire general health questionnaire manual general health questionnaire great results demonstrated moderating effects self acceptance self esteem relationship frustration intolerance beliefs achievement emotional intolerance discomfort intolerance psychological distress present findings highlight importance self acceptance reduces emotional problems students educational personal growth
defined decreased triiodothyronine normal thyroid stimulating hormone tsh levels present many acute diseases related increased mortality studied low levels relation long term mortality non elevation acute coronary syndrome patients tsh levels consecutive patients measured patients normal tsh levels low level defined low group patients normal tsh levels defined normal group clinical laboratory findings two groups compared addition examined low levels relation early long term mortality patient age male patients low level free values negatively correlated age serum creatinine brain type peptide values time admission respectively mortality month year higher low group respectively multivariate analysis low found related mortality year roc analysis free good area curve auc value mortality year auc related increased early late mortality patients free levels used identify patients high mortality risk
background patients advanced cancer dependent children important population life limiting illness high levels psychological distress studies addressed experience parent advanced cancer potential palliative needs aim describe experience living advanced cancer parent including illness experience parental concerns treatment decision making explore whether experiences differ functional status design conducted cross sectional qualitative study using depth semi structured interviews data analyzed using thematic content analysis setting participants total participants metastatic cancer least one child age years recruited comprehensive cancer center participants rated high functional status eastern cooperative oncology group performance status scale low functional status results identified four themes regarding experience parent advanced cancer parental concerns impact illness death children missing losses parental role responsibilities maintaining parental responsibilities despite life limiting illness parental identity influencing decision making treatment parental functional status influenced physical responsibilities also intensified parenting psychological concerns conclusion parents metastatic cancer unique palliative care needs experience parenting concerns managing psychological physical demands advanced cancer
empathy complex construct thought contain multiple components one popular measurement paradigm interpersonal reactivity index used extensively measure empathic tendencies schizophrenia research across four domains empathic concern perspective taking personal distress however recent meta analysis conducted four factors scale goal meta analysis examine self reported empathic tendencies factor people schizophrenia compared healthy controls literature search revealed eligible schizophrenia studies standardized difference effect size calculated component using random effects meta analytic model compared healthy controls schizophrenia samples reported significantly reduced tendencies empathic concern perspective taking significantly greater tendencies personal distress duration illness significantly moderated results perspective taking longer duration exhibited greater deficits percent female significantly moderated results personal distress samples females exhibited reduced effect sizes future work needed examine impact heightened personal distress empathic tendencies abilities schizophrenia including possible role emotion regulation
study presents indoor framework detail describing variables factors form indoor study main objective introduce new indoor framework systematically explain variables contribute overall evaluation indoor hence dependencies physical factors sound environment spatial factors built entity statistically tested new indoor framework leads overarching evaluation perspective sound environments combining objective room research noise control engineering architectural analysis therefore hypothesised case spaces certain plan organisations volumetric relations spatial lead differentiated sound pressure level values parametric sound environments discussed statistical findings respect architectural characteristics library case space results show relation level sound environment parametric values statistically significant also found increasing height void volume presence common architectural element reference domain results unwanted acoustic leading high values
amounts deposits triggered earthquake magnitude deposits composed soil rock fragments play important roles hydrological erosion processes steep slope deposits mixtures soil common top layers deposits processes obviously different soil without based data field investigation series simulated flow experiments four proportion gravel three flow rates min two steep slopes conducted sequentially know effects proportion gravel infiltration capacity runoff generation sediment production steep slope results indicated gravel promoted reduced effects infiltration capacity affect cumulative runoff volume cumulative sediment mass increase decrease cumulative infiltration volume proportion gravel less proportion gravel cumulative runoff volume order cumulative sediment mass ranked different proportions gravel significant power relationship found time cumulative runoff volume cumulative sediment mass relationship average soil water loss rate proportion gravel able express quadratic function high degree reliability results important implications soil water conservation modeling also provide useful information similar conditions
microarrays quantitatively measure expression thousands genes simultaneously also powerful tools examine expression specific genes different tissues cell types complement methods used detect gene expression transcript level including northern blotting pcr study uses oligonucleotide microarray expression profiling compare maize beta gene expression transcript level different tissues various stages development adds known maize beta expression maize least nine beta genes expressed presence multiple genes suggests evolved provide fine control expression even distinct biological physiological properties plant supported differential expression transcript level maize beta different tissues development following work added evidence maize beta gene differential expression regulation based oil microarray data beta exhibit statistically significant differences transcript abundance day old shoots immature embryos also different expression patterns many genes within tissues studied plant develops use beta different amounts specific tissues even interact differently proteins present developmental stages immature higher transcript comparisons expression patterns indicate similar expression patterns result similar transcriptional regulation highest transcript abundance two genes occurs developing shoots transcripts also detected first time maize chapter describes variety methods array analysis gene expression important considerations taking oil type work
background purpose cerebral venous thrombosis affects venous provoke severe stroke chronic intracranial hypertension sought comprehensively analyze dimensional blood flow hemodynamic alterations acute including recruitment follow methods twenty two consecutive patients acute prospectively included underwent routine brain magnetic resonance imaging mri dimensional flow mri vivo assessment cerebral blood flow neurological mri follow months performed patients results three dimensional blood flow visualization quantification large venous deep cerebral veins successfully performed patients acute observed abnormal flow patterns including flow flow acceleration change flow directions patients complete flow trajectories known previously published dimensional flow mri data healthy adults trend toward relationship segments cerebral lesions significant furthermore patients versus without cerebral lesions showed increased mean versus peak velocities versus within partially left right transverse baseline conclusions four dimensional flow mri successfully applied dimensional visualization quantification venous patients provided new dynamic information regarding vessel technique seems promising investigate contribution hemodynamic parameters larger cohort identify risk stroke
study laser metal deposition additive manufacturing used pure alloy composites different starting sizes particles respectively influence additive particle original size constitutional phases microstructural features mechanical properties processed parts studied incorporation particles significantly changed prominent texture matrix phase bottom side parts deposited track showed mostly cellular prevailing microstructure central zone deposited track nano particles added observed pool incorporation nano particles induced formation significantly refined secondary arms developed considerably micro particles added relatively highly secondary growth entirely suppressed cellular obviously refined additive particles nano particles added reinforce significantly improved tensile property wear property obtained without composites
paper novel compact high voltage test system based controlled resonant transformer proposed system used perform power frequency site voltage test first basic principle introduced next fourier analysis based equivalent magnetic electrical circuits described analysis provides design reference basic parameters addition finite element model constructed verify design finally prototype designed verify effectiveness test system compared traditional test systems proposed test system paper advantages compact structure stable secondary voltage wide adjustment range
background direct acting oral anticoagulants used patients vein thrombosis cirrhosis evidence safety efficacy setting limited aim identify indications reasons starting switching report adverse effects complications short term outcome methods data collection including demographic information laboratory values treatment complications vascular liver disease interest group consortium results forty five centres consortium completed initial report series patients centres thirty six patients cirrhosis child score range score range indications anticoagulation vein thrombosis deep vein thrombosis atrial fibrillation others used patients followed median duration months months non adverse events occurred patients included one case recurrent portal vein thrombosis five cases bleeding treatment stopped three cases major reasons choosing need monitoring guide anticoagulation patients renal liver function change treatment conclusions consistent number patients cirrhosis currently treated seem effective safe data provide basis performing randomized clinical trials low molecular weight heparin vitamin antagonists
endogenous oxytocin system plays vital role facilitating lactation social interaction humans mammals also impacts number important endocrine immune neurotransmitter systems regulated oxytocin system proposed increase resilience therefore reduce likelihood individual developing mental illness substance dependence review discusses adverse external influences modulate oxytocin receptor protein levels impact substance use mental health paper highlights impact adversity poor maternal care parental substance use child abuse neglect review clinical preclinical data impact adversity basis time exposure infancy early childhood adolescence adulthood older age previous research suggests dysregulation endogenous oxytocin system implicated determining susceptibility stress anxiety addiction mental health conditions impact external influence seems strongest specific time periods system shows experience based development natural fluctuations oxytocin levels interventions target oxytocin system soon exposure adversity prove protective copyright wolters kluwer health inc rights reserved
regional temperature quantitative regional cerebral blood flow responses cortical spreading depolarization rat continuously monitored tissue using thermal diffusion sensor measures cycles regional cerebral blood flow response four phases including early peak baseline duration late minimum duration temperature rose start regional cerebral blood flow response peak increase degrees returned baseline near start technology useful multimodal monitoring laboratory clinic
research suggested metabolized cleavage catalyzed beta resulting generation reported previously raw tomato now show several also present raw processed foods human plasma standards prepared vitro oxidation high performance liquid chromatography tandem mass spectrometry hplc method using atmospheric pressure chemical ionization negative mode developed separate detect products formed reaction extracts raw tomato red processed tomato products analyzed plasma individuals consumed tomato weeks detected quantified food products tested plasma sum tomato tomato nmol plasma conclude several addition present containing foods addition presence plasma derive absorption directly food human metabolism
cancer stem cells tumor initiating cells small subset neoplastic cells able produce tumor tumorigenesis maintain population cells self renewal generate heterogeneous cells constructing entire tumor research stationary circulating due resistance conventional therapies inability complete eradication cancer critical developing novel therapeutic strategies effective reduction risk tumor metastasis cancer recurrence review information different methods detection dissociation side population cellular markers establishment culture characteristics signaling pathways associated self renewal capability histological tumor regeneration various cancers
bim building information modeling form built model information sharing platform emerged powerful solution dynamic requirements architecture engineering construction however whereas fast accurate reconstruction building essential collaborative construction management process manual creation utilization built model typically results low productivity erroneous modeling results paper proposes semi automated method accounts major problems manual process built model creation bim method generates model combined data imported bim tool built modeling present study evaluates proposed method applying two typical rooms test building built model subjected accuracy assessment using reference points acquired total station contributions proposed method compared fully manual operation reduction huge data size original point clouds improvement productivity built bim creation aid accuracy enhancement refinement process entails segmentation regularization however proposed method limited building consisting planar structures modeling detailed objects windows unfortunately still requires manual operation thus research detail modeling refinement necessary order increase methods automation enhancement overall suitability mapping complex indoor environments elsevier ltd rights reserved
work surveys students materials engineering carried evaluate different aspects use information communication technologies ict studying habits willingness incorporate new tools based data collection different trends detected concerning use resources interest incorporation new instruments facilitate studying students basic courses first two years career show interest incorporate new technological resources studying however students upper courses last three years favor proposal way students upper courses use technological resources advanced many times related professional activity also possess information regarding existence resources work online based field study propose incorporate new technological resources teaching methodology systematically progressively throughout course studies proposal considers use free access free charge tool google four progressive levels global evaluation proposal immediate since need follow evolution cohort progressive utilization implemented process takes least five years nevertheless proposal help teachers students carry specific tasks inside outside university
clinicians currently use different low weight cut offs diagnose anorexia nervosa determine severity adolescent girls purpose study evaluate clinical utility existing cut offs severity criteria determining strongly associated risk low bone mineral density bmd height adjusted bmd scores calculated females healthy controls controls years using data bmd childhood study lumbar spine whole body less head total hip cut offs used define low weight bmi percentile bmi median bmi lower bmd scores controls expected body weight height differ bmd scores controls differed significantly among associated lower bmd lower bmd controls across dsm society adolescent health medicine severity categories moderate severity classification differentiated classification lower bmd hip spine sites markers severity bone loss within among severity categories bmi scores greatest utility assessing degree malnutrition adolescent girls corresponds lower bmd
human dose biochemical effect nowadays tremendous utility providing efficient cost effective means measuring human exposure chemical substances considers routes uptake sources relevant making ideal instrument risk assessment risk management identify new chemical exposures trends changes exposure establish distribution exposure among general population identify vulnerable groups populations higher exposures identify environmental risks specific contaminated sites relatively low expenditure sensitivity methods moreover enables elucidation human metabolism toxic mechanisms pollutants tool scientists policy makers blood urine far approved matrices done chemical substances focus worldwide discussion environmental medicine especially applies metals pesticides aromatic chemicals environmental tobacco smoke volatile organic compounds protein especially dna measuring exposure biochemical effect specifically still better means estimate cancer risk measuring substances metabolites human body fluids using sophisticated nevertheless routinely applicable analytical procedures agents aromatic aromatic compounds determined routinely today extend spectrum biochemical effect monitoring methods elaborated put cleavage separation protein molecules measure sample preparation way sites proteins like serum albumin used dna indicate chemical substance elevated cancer risk dna therefore ideal parameters though sensitive techniques dna monitoring like immunological methods lack specificity elucidating mechanism carcinogenesis broad applicability epidemiological studies analytical methods elaborated strictly specific chemical structure dna current analytical possibilities however meet studies exposure chemicals especially measurement dna strand breaks lymphocytes hydroxy white blood cells become popular however still lack established dose response relations occupational environmental exposures induction formation strand breaks limits applicability markers biomarkers used population studies covered standard operating procedures internal external quality assessment schemes therefore results leading laboratories worldwide analytically reliable comparable newly upcoming substances environmental relevance like compounds rapidly assessed body fluids getting difficult laboratories keep progress instrumental analyses spite pay reach ultimate way identify quantify human exposure risk elucidate mechanism toxic effects ultimately decide measures taken reduce exposure risk assessment risk management without lead wrong risk estimates cause inadequate measures countries like usa germany thousands inhabitants regularly investigated respect internal exposure broad range environmentally occurring substances evaluation results german commission reference values elsevier gmbh rights reserved
transportation engineers face many problems using sand available huge quantities areas construction materials roads study consists using sand local material road construction two approaches adopted achieve goal first carrying laboratory tests simulation three layers road using steel box model layer represented sand relative density value study oriented improvement sand using reinforcement two types geosynthetic material two models studied one reinforced single layer geotextile interface using single layer geogrid depth improve technique used injection mixture cement water using geotextile geogrid leads increase number passes respectively using injection technique increase number passes approach using program applied find displacement distribution build pavement structure model results obtained laboratory finite elements much encouraging using sand construction materials roads however using reinforcement interface also satisfied minimum stability requirements roads foundation structure sand layer
purpose research identify different types fear related starting antiretroviral therapy art among people living hiv russia data collected russian language internet qualitative data analysis focused sections users discussed health related issues order identify related hiv treatment following types fear revealed fear illness fear learn negative information ones health fear side effects fear therapy ineffective fear appropriate medications become unavailable fear lifestyle changes fear significant others efforts increase uptake adherence art take account
high level concern placed storage handling transportation distribution vaccines pharmaceutical products particularly time temperature sensitive active passive cooling equipment monitoring devices important various personnel responsible executing writing procedures designing operating systems investigating problems helping prevent paramount establishing maintaining time temperature sensitive pharmaceutical products professionals possess required competencies knowledge skills abilities effectively perform activities appropriate levels expertise complex tasks require development higher cognitive skills adequately addressed professional development opportunities based simple information delivery content acquisition paper describes two unique learning solutions one bus called wheels course online called learning developed global learning opportunities provide participants opportunities just learn cold chain systems vaccine management rather develop high levels expertise respective fields experiential authentic learning activities interactive learning environments participants opportunities address real life situations contexts similar face work environments develop solutions critical thinking skills apply return jobs paper managerial operational vaccine management functions two unique learning environments paper also describes alignment objectives addressed wheels course learning version effective vaccine management criteria prescribed paper concludes example real world product developed course graduates specifically decision tree now used national programmes types products valuable right often emerge learning environments based authentic learning principles designed implemented authors published elsevier ltd
paper focus concept reduce complexity connectivity integrated manufacturing engineering system using enterprise service bus approach software platform developed designing implementing interaction communication mutually interacting software subsystems modules manufacturing engineering systems developed approach enables manufacturing engineering systems make use comprehensive flexible consistent integration reduce complexity applications integrated main objective current study analyse systems integrate data activities considered products supply chain floor management processes
distributed computing good alternative expensive frameworks enable programmers harvest remote computing power however today much computation power edges internet remains devices contribute distributed environment generic computation resources computation intense applications use pool resources enhance execution quality paper identify heterogeneity major burden distributed edge computing heterogeneity present multiple forms draw vision comprehensive distributed computing system show existing frameworks fall short dealing heterogeneity distributed computing afterwards present system approach distributed computing framework fine grained computation units issued remote local execution tackle different dimensions heterogeneity show make use available computation power edge resources prototype use middleware virtualization technologies host language concept
purpose adrenal venous sampling generally considered gold standard identify unilateral hormone production cases primary aim study evaluate whether iodine beta test represent alternative selected cases methods patients submitted laparoscopic suspected primary retrospectively reviewed nuclear medicine tests preoperatively performed results compared findings clinical improvement results nuclear medicine tests realized patients planar anterior posterior performed two indicated preoperative patients value tests based pathologic results showed sensitivity positive predictive value nuclear medicine tests performance based postoperative blood pressure control sensitivity positive predictive value conclusions nuclear medicine tests represent useful tool preoperative primary high sensitivity positive predictive value patients adrenal venous sampling like contrast allergies inconclusive represent useful non invasive alternative
human dna oxidative dna lesion dna kinetic characterization undertaken measure rates excision product release concentration lower substrate dna time courses product formation rapid exponential phase burst product formation followed linear steady state phase initial burst product formation corresponds concentration enzyme properly engaged substrate burst amplitude depends concentration enzyme first order rate constant burst corresponds intrinsic rate excision slower steady state rate measures rate product release product dna dissociation rate constant describe steady state pre steady state single turnover approaches isolate measure specific steps catalytic cycling fluorescent labeled lesion containing oligonucleotide purified used facilitate precise kinetic measurements since low enzyme concentrations used make steady state measurements manual mixing reagents quenching reaction performed ascertain steady state rate additionally extrapolation steady state rate point zero time indicates burst product formation occurred first turnover positive first order rate constant exponential burst phase measured using rapid mixing quenching technique examines amount product formed short time intervals approaches measure elementary rate constants influence efficiency removal dna lesion
aims adults experienced conflicts republic exposed multiple traumatic events stressors many years aim investigate coping strategies used conflict affected persons association mental disorders method cross sectional survey conducted adults representing internally persons conflicts former returned homes conflict post traumatic stress disorder depression anxiety coping strategies measured using trauma screening questionnaire patient health questionnaire generalised anxiety adapted version brief coping inventory respectively descriptive multivariate regression analyses used results coping strategies use emotional support active coping acceptance religion significantly associated better mental health outcomes coping strategies behavioural mental denial emotions substance abuse gambling significantly associated poorer mental health outcomes reported use coping strategies varied significantly men women strategies addressed conclusions many conflict affected persons still suffering mental health problems years conflicts number specific coping strategies appear associated better mental health encouraged supported possible
purpose study compare analyze effects two instructional methods led simulation based instructions engineering students achievements anti course interests manufacturing engineering class twenty nine undergraduate students participated study anti repeated measures employed collect multiple sets data study showed significant differences means achievement anti interests results discussed conjunction data tables
non codes defined ics provide roughly following guarantee encoding message equal message contained reveals information codes applications attacks related key attacks one efficient non code protects efficient functions however paper show next best polynomial bound given priori efficient non code protects functions circuit size generally family functions size vertical bar vertical bar efficient non code protects element rate codes defined ratio message size approaches results information theoretic main proof technique relies careful probabilistic method argument using limited independence result get efficiently family efficient codes random member family non overwhelming probability alternatively view result providing efficient non code common reference string model also introduce new notion non key derivation uses randomness derive secret key way even different value derived key reveal information results non key derivation analogous non codes useful tool analysis rely notion leakage resilient storage result independent interest also significantly improve parameters schemes
paper practical pole placement technique proposed shape dynamic response large scale structure end similarity transformation mass stiffness matrices large scale structure applied system coupled second order ordinary differential equations system equations represents large scale structure transformed principal coordinates new coordinate system special state feedback controller called inner loop used system equations reduce second order since system now represented second order poles second order assigned one time using separate proportional derivative controller set controllers form outer loop paper full state feedback controller simply aggregation inner outer state feedback loops sought assign poles large scale structure analytical proof proposed state feedback controller places poles large scale structure provided final part paper poles large scale structure assigned using pole placement technique proposed research
inherently interdisciplinary pursuit largely stems fact techniques used investigate given bio mineral ideally married techniques provide insight biological mechanisms form mineral vice versa observe two broad challenges inhibit exchange ideas information materials scientists first emerging rapidly evolving techniques available alike make difficult expert remain contemporary non expert second truly integrate relate specific biological insight genesis effect insight properties mineral trivial propose evolutionary developmental biology approach address challenge also provide deep insight rich diversity structures evolved approach previously employed groups recent exciting methodological developments available molecular now make strategy even attractive short review aim outline perception role play within field taking case study past achievements recent insights future research directions associated formation elsevier inc rights reserved
european academy allergy clinical immunology junior members comprise largest section around clinicians scientists years age working field allergy clinical immunology junior member collaboration clinical translational allergy journal mutually beneficial relationship providing junior members excellent opportunities work journal enhance visibility respective field get involved journal related activities processes future collaboration grow consolidation activities also implementation new initiatives platform discussing publishing junior members journal perspective collaboration presents opportunity promote new generation experience conducting presenting research improved skills critical review
numerical morphological modeling rivers using physics based approach increasingly used technique explore controls river pattern applied perspective simulate impact channel modifications paper assesses depth averaged sediment model predict long reach river new zealand single high flow event evaluation model performance primarily focused upon using high resolution digital elevation models difference derived fusion terrestrial laser scanning optical empirical mapping compare observed predicted patterns erosion deposition reach scale sediment calibrated model supplemented metrics intensity extensive sensitivity analysis model functions parameters executed including consideration numerical scheme bed load component calculations hydraulics bed composition bed load transport bed slope effects bank erosion frequency calculations total predicted volumes erosion deposition corresponded observed difference predicted observed volumes erosion less factor two characterizes accuracy bed load transport formula grain size distributions best represented using two intervals unsteady flows results sensitive morphological time scale factor approach comparing observed predicted morphological sediment shows value using natural experiment data sets model testing sensitivity results guide applications rivers
family sex chromosomes quality model plant analysis sexual evolution yet little known physical side genetic orientation substitution behavior key gender defining factors important plant species screening genomic dna primers used sex diagnosis gender specificity study bulk analyses pooled dna male female genotypes resulted isolation putative male specific sex marker sequence characterized amplified region marker designed amplified fragment male female plants southern blotting confirmed single copy locus male genome marker accurately identified male female genotypes individuals unknown sex sequence homology revealed high similarity putative box domain box gene responsible development plants thus marker used efficient tool early sex identification forms basis characterization genes associated evolutionary pathways sexual elsevier rights reserved
finding better method acute myeloid aml induction designed prospective clinical trial find effective regimen least toxicity induction therapy aml hence examined different accepted doses outcomes total patients included study fifty five patients received arm infusion remaining received arm infusion continuous infusion day given groups complete remission rate group group one year overall survival standard error arm arm median follow time months respectively one year disease free survival arm arm complete remission overall survival disease free survival statistically groups toxicity safety profile similar two groups need transfusion higher arm neutropenia days antibiotics consumption invasive fungal infection prevalence show difference mean packed cells platelets rate higher group received higher dose considering results found rational effective lower toxicity induction therapy aml patients least scheduled trial copyright john wiley sons ltd
study presents development new fault zone identification scheme using logistic regression binary classifier utilising one cycle post fault current signals connected presented scheme verified modelling existing indian power generating station power systems computer aided design electro magnetic transient design control software package presented scheme tested enormous cases generated varying system fault parameters proposed scheme provides effective discrimination internal external faults high overall accuracy moreover remains stable case heavy fault conditions particularly current transformer saturation conventional differential protection scheme operates furthermore provides equally compatible accuracy unknown system data set double one half arrangement addition performance proposed scheme verified laboratory prototype results found satisfactory average time order case internal faults last comparative evaluation proposed scheme recently presented schemes literature indicates superiority
grid connected converter control grid voltage feedforward usually introduced suppress influence grid voltage distortion converters grid side current however owing time delay control systems suppression effect grid voltage distortion seriously affected paper positive effects grid voltage feedforward control analyzed detail time delay caused low pass filter voltage filtering circuits digital control summarized order reduce time delay effect performance feedforward control voltage feedforward control strategy time delay compensation proposed leading correction feedforward voltage used optimal leading step used strategy derived analyzing phase frequency characteristics implementation digital control using optimal leading step delay feedforward path performance feedforward control terms suppressing influence grid voltage distortion converter output current improved validity proposed method verified simulation experiment results
rapid integration global agricultural markets subsequent displacement recent decades increased large scale tropical south america southeast asia growing land scarcity stringent land use regulations regions export oriented commodity crops sub saharan africa assess effects domestic export oriented agricultural expansion recent decades analyses conducted global regional local scales found commodity crops expanding increasing pressure tropical forests four basin countries risk terms exposure vulnerability pressures agricultural expansion countries averaged highest percent forest cover lowest proportions potentially available outside forest areas foreign investment countries concentrated oil palm production median investment area thousand fastest expanding export oriented crop across accounted global expansion rate thousand however foreign land investment commodity crop expansion appears largely driven small farmers rather industrial land use changes associated large scale investments remain observed many countries although domestic demand commodity crops associated agricultural expansion provide evidence growing influence distant markets land use change
paper parasitic resistance capacitance lateral field effect transistor studied detail parasitic components modeled extracted using technology computer aided design simulation tool extraction results extension length turned dominant factor determining intrinsic gate delay single also contact structure stacked also investigated view parasitic constituents based extracted parasitic resistance capacitance optimal source drain extension length obtained considering two parasitic components inverse trend change extension length
background health related benefits intimate partnership documented little attention paid couples exposed high levels social stigma exclusion project investigated important site stigma partnerships collecting accounts changing hepatitis hcv status change among couples drugs explored accounts reveal meaning hcv couples understanding contributes collective efforts prevention care methods drawing large dataset qualitative interviews couples focussed containing reports change adopting methodology positioned partnerships rather individuals primary unit analysis addressed tendency either dysfunctional sexual relationships people drugs results couples sought greater biomedical understanding means coming terms change others alternative outside conventional biomedical discourse notions example regardless explanatory framework participants ultimately security relationship viral infection conclusions effectively engaging couples hcv prevention care requires working competing priorities complex partnerships beyond simply identification viral risk new era direct acting antiviral treatments provide ongoing opportunities learn integrate biomedical information within socially sophisticated aware approaches elsevier rights reserved
background facilitate priority setting health compiled best available information estimate adult mortality years burden attributable metabolic lifestyle infectious environmental risk factors taiwan methods obtained data risk factor exposure nationally representative health surveys cause specific mortality national death registry relative risks epidemiological studies meta analyses applied comparative risk assessment framework estimate mortality burden attributable individual risk factors risk factor clusters results high blood glucose accounted deaths deaths year followed tobacco smoking deaths high blood pressure deaths ambient particulate matter pollution deaths dietary risks high sodium intake low intake fruits vegetables deaths overweight obesity physical inactivity accounted deaths deaths respectively cardiometabolic risk factors high blood pressure high blood glucose high cholesterol overweight obesity jointly accounted deaths cardiovascular diseases domestic risk factors infections hepatitis virus hbv hepatitis virus hcv responsible deaths deaths respectively use associated deaths oral laryngeal esophageal cancer leading risk factors years life lost similar impact tobacco smoking alcohol use became larger attributable deaths risk factors occurred among young adults aged less years conclusions high blood glucose tobacco smoking high blood pressure major risk factors deaths diseases injuries among taiwanese adults large number years life gained modifiable risk factors removed reduced optimal level
according solid mechanics application set external actions body results modification state variables stress characterizes intensity internal forces point medium necessary know stress distribution quantifying resistant capacity solid calculation stresses applies supporting elements structure mechanical components machine respectively studied disciplines strength materials mechanical engineering work presented within context strength materials calculation stress distributions commonly used structural sections subjected bending means two virtual laboratories implemented purpose interest laboratories lies support provide teaching learning subject far allow calculate display distribution normal shear stresses according formulation explained lectures
particulate formation due combustion wide range ethanol gasoline blends investigated internal combustion engine engine used study single cylinder research engine architecture representative modern spark direct injected engine instead direct injection engine using mode supplied fuel engine mixed gas phase air fuel mixture order isolate physical effects fuel created completely homogenous air fuel mixture significantly differing equivalence ratio liquid fuel droplets surfaces ensuring particulate formation due homogenous gas phase combustion engine operated fixed load effects varying equivalence ratio ethanol content examined results work show addition ethanol results consistent decrease engine particulate proportional ethanol content moreover critical equivalence ratio equivalence ratio significant begins increases linear fashion ethanol addition also shown shape particulate size distribution affected ethanol content increased ethanol leading mode dominated distributions author published elsevier ltd
rare events especially potentially negatively impact society often require humans decision making responses detecting rare events viewed prediction task data mining machine learning communities events rarely observed daily life prediction task suffers lack balanced data paper provide depth review rare event detection learning perspective five hundred seventeen related papers published past decade collected study initial statistics suggested rare events detection learning concerned across wide range research areas management science engineering reviewed collected papers technical practical point view modeling methods discussed include techniques data preprocessing classification algorithms model evaluation applications first provide comprehensive taxonomy existing application domains learning detail applications category finally suggestions reviewed papers incorporated experiences judgments offer research directions learning rare event detection fields elsevier ltd rights reserved
last decades perception selenium undergone substantial changes toxic effects recognized causing hair loss animals essential role microbial animal human metabolism recognized later discovery selenium deficiency causing white muscle disease nowadays positive effect systematic selenium supplementation discussed manifold topics cancer diabetes prevention avian influenza susceptibility treatment selenium containing waste streams poses notable challenge environmental engineers date ultimate solution found selenium contamination agricultural areas western usa future selenium contamination carries danger increasing energy demand covered fossil fuel combustion lead major selenium emission toxicity review presents current knowledge role environmental sciences outlines potentially feasible treatment options targeting variety selenium contaminated waste streams elsevier rights reserved
psoriasis common inflammatory skin disease exact pathogenesis largely unknown interleukin demonstrated vital role cell mediated immune response interacting keratinocytes pathogenesis psoriasis showed differentially expressed mirnas potential targets cells stimulated using mirna mrna microarrays revealed total significantly changed twofold mirnas cells validated results quantitative reverse transcriptase pcr qrt pcr demonstrated mir regulated cells stimulated psoriatic lesions aimed investigate biological roles potential mechanism mir keratinocytes result assay indicated overexpression mir keratinocytes promoted proliferation conversely inhibition endogenous mir suppressed proliferation according microarray analysis assumed negative regulator extracellular signal regulated kinase mitogen activated protein kinase signalling pathway direct target gene mir found staining cytoplasm mainly localized basal layers epidermis showed markedly decreased expression psoriasis normal control immunohistochemistry luciferase reporter western blot assays cells demonstrated direct target gene mir conclusion induced mir promotes keratinocyte proliferation possibly expression thus playing important roles pathogenesis psoriasis
harness heterogeneous memory hierarchy advantageous integrate application knowledge guiding frequent memory move replicating virtual memory regions end present protected service asynchronous hardware accelerated memory move compared state art page migration linux low overhead low latency order semantics kernel interface also underlying mechanisms including request completion management race handling engine configuration implement linux server class system chip features heterogeneous memories compared current linux page migration reduces cpu usage small pages large pages continuously serving requests need request reduces latency small runtime improve set streaming workloads overall opened door software management heterogeneous memory
hybrid electric vehicles regenerative braking effective way energy conservation however braking energy usually regenerated completely due limit motor maximum torque braking torque provided electric motor meet drivers braking demand hydraulic brake system provide extra braking torque results braking energy loss therefore meaningful adjusting work point maximize regenerative energy transmission paper hev equipped automated manual transmission chosen study platform first simplified dynamic models hev system built process advantages analyzed characteristics regenerative braking obtained different gear positions different two kinds strategy proposed basis last hardware loop tests carried results show energy conservation regenerative braking process increased compared without elsevier ltd rights reserved
years many efforts made problem constructing quality fault tolerant virtual wireless network case wireless network consists physically equivalent nodes communication range unit disk graph widely used abstract wireless network problem formulated minimum connected set problem far results focused designing constant factor approximation algorithm hard problem two positive satisfying however found structures algorithms extremely complicated thus difficult implement use practice motivated observation paper introduces novel approximation algorithm problem algorithm based new technique first computes connected set repeatedly connected block tree use graph structure improve connectivity becomes connected provide rigorous theoretical analysis prove proposed algorithm correct approximation ratio constant compare structure algorithm existing ones show algorithm much simpler understand implement
background based recent findings impressions took closer look relationship inter psychometric variables migraine patients findings study included female migraine patients female controls mean age years years respectively participants filled depression anxiety stress scale patients significantly higher controls patients showed statistically significantly higher levels depressive symptoms anxiety symptoms stress controls among participants correlated positively age rho levels depressive symptoms rho anxiety symptoms rho stress rho gender patients correlated positively age rho rho linear regression analysis revealed trend towards statistical significance predictor level depressive symptoms rho whole sample conclusions considering higher levels depression comorbidity migraine depression possible depression contributes patients migraine true anxiety stress also related migraine possible impact migraine explained dysfunction
objectiveto systematically review literature perceived barriers facilitators help seeking eating disorders databases pubmed cochrane searched using keywords medical subject mesh terms retrieved abstracts double screened relevant papers double coded qualitative quantitative studies included reported perceived barriers facilitators towards seeking help eating disorders barriers facilitators extracted included papers coded themes prominent barriers facilitators determined number studies reporting theme qualitative three quantitative two mixed methods studies met inclusion criteria current review prominent perceived barriers help seeking stigma shame denial failure perceive severity illness practical barriers cost treatment low motivation change negative attitudes towards seeking help lack others seek help lack knowledge help resources facilitators help seeking reported six studies prominent themes identified presence mental health problems emotional distress concerns health targeting prevention early intervention eating disorders focus reducing stigma shame educating individuals severity eating disorders increasing knowledge around help seeking pathways eating disorders wiley periodicals inc int eat revision bases pubmed cochrane mesh los los para los mas los inclusion para revision mas para son los los los mas mental los los los los para para los int eat
children born congenital heart malformations clinical animal studies suggest abnormal blood flow forces play role causing highlighting importance understanding fetal cardiovascular fluid mechanics performed computational fluid dynamics simulations right based four dimensional ultrasound scans three old normal human fetuses characterize flow energy dynamics peak pressure gradients found mmhg mmhg diastolic wall shear stresses found around outflow tract fetal right complex flow patterns featuring two interacting diastolic vortex rings formed diastolic wave wave rings persisted end elevated wall shear stresses proximity observed similar peak diastolic kinetic energy carried subsequent however carried kinetic energy significantly alter work done heart ejection thus diastolic played significant role determining spatial patterns magnitudes diastolic wall shear stresses significant influence systolic ejection results serve baseline future comparison diseased
cloud security become one emergent issues immense growth cloud services major concern cloud security threat harm poses therefore cloud systems attacks become key demand work deals threat cloud relational database systems reveals flaws cloud computing use launch attacks discusses load balancing across availability zones increase threat mitigate kind threat paper proposes four models peer peer model centralized model mobile model guided mobile model discusses advantages limitations moreover paper provides experiments analysis compare among proposed models demonstrate effectiveness show conditions work highest performance copyright john wiley sons ltd
past research demonstrated perceivers likely draw spontaneous trait inferences stis stereotype consistent behaviors stereotype inconsistent behaviors four studies conducted examine moderating role power stereotype effects stis priming power using task study found high power participants stis elderly stereotype consistent elderly stereotype inconsistent low power participants draw stis elderly stereotype consistent stereotype inconsistent behaviors study replicated findings study exploring moderating role power gender stereotype effects stis measuring participants power via personal sense power study found power also moderated effects gender stereotype stis study found compared baseline condition manipulation low power condition inhibited stis stereotype consistent behaviors high power condition facilitate formation stereotype consistent behaviors current study first show power influences reliance stereotypes spontaneously inferring traits behaviors
autism spectrum disorder asd condition defined along continuum difficulties associated unique patterns memory functioning including difficulties memory refers memory information related self experienced events strong social function current paper reviews empirical studies assessing among individuals asd across lifespan results support children adults asd manifest difficulties characterized reduced specificity less elaborated detailed narratives lower coherence increased reliance retrieval individuals asd also demonstrate intact certain memory indices show evidence using compensatory strategies facilitate retrieval results interpreted relation models typically developing broad memory theory models information processing specific asd advance knowledge develops within context asd developmental psychopathology perspective applied consideration candidate processes underlying developing among individuals asd future research consider support mechanisms promote performance multiple ecological levels limitations clinical implications intervention future directions discussed elsevier inc rights reserved
previous studies show excellent particulate mixing bed reduce operating cost therefore paper investigates enhancement particulate mixing bed using novel inclined reduce cost pumping power small size low pressure used study moreover group bed materials different bed aspect ratios designs viz plate circular novel used novel inclined found effective enhancing circulation rate flow pattern bed materials clock wise direction obvious shallow bed two layer lateral circulation motions observed deep bed concluded study excellent particulate mixing per made possible novel type without implementation electric motor mechanical rotation society powder technology japan published elsevier society powder technology japan rights reserved
paper presents optimal designs two analogue complementary metal oxide semiconductor cmos amplifier circuits namely differential amplifier current mirror load two stage operational amplifier modified particle swarm optimization pso called based particle swarm optimization technique applied minimize total mos area designed circuits highly modified version conventional pso adopts number random variables better faster exploration exploitation capability multidimensional search space integration factor fundamental velocity term pso brings diversity particles also convergence close global best solution proposed based circuit optimization technique free intrinsic disadvantages premature convergence unlike differential evolution search artificial colony abc particle swarm optimization pso simulation results achieved two analogue cmos amplifier circuits establish efficacy proposed based approach abc pso terms convergence design conditions design goals optimally designed analogue cmos amplifier circuits least mos area show best performance parameters like gain power dissipation compared reported literature copyright john wiley sons ltd
introduction invasive non salmonella infections cause high burden lethal sepsis young children hiv patients often associated malaria malnutrition cell disease vaccines urgently needed none licensed yet areas covered review illustrates immunology epidemiology within host pathogen behaviour affect invasive salmonella infections highlights knowledge assist improvement choice vaccines expert commentary control disease requires approaches reduce transmission improve diagnosis treatment often difficult implement due fragile ecology endemic countries vaccines key tools fight disease optimise vaccine design need better define protective antigens mechanisms resistance disease susceptible populations even individuals innate immunity impaired widespread comorbidities
background chronic insomnia major public health problem affecting approximately adults use develop awareness mindfulness training effective approach treat chronic insomnia sleep outcomes comparable use prescription durable minimal side effects purpose study understand mindfulness training experienced patients chronic insomnia suggest procedures useful optimizing sleep benefits methods adults completed week mindfulness based stress reduction program part randomized controlled clinical trial evaluate treatment chronic insomnia invited participate post trial focus groups two groups held participants described sleep routine thoughts emotions affected utility various mindfulness techniques groups audio recorded transcribed analyzed using content analysis results four themes identified impact mindfulness sleep motivation adopt healthy sleep lifestyle benefits mindfulness aspects life beyond sleep challenges successes adopting mindfulness based practices importance group sharing support participants said sleeping sleeping better feeling less insomnia better able cope occurred participants experienced course call action practicing following sleep hygiene guidelines became priorities motivation sustain behavioral changes reinforced feeling physically better emotionally stable seeing others class improve body scan identified effective tool enable falling faster participants described needing continue practicing mindfulness maintain benefits conclusions first person accounts consistent published trial results positive impacts sleep measured sleep diary actigraphy self report sleep scales findings indicate mindfulness training group format combined sleep hygiene education important effective application treatment chronic insomnia
objective define values normalized brain volume categorized low medium high according baseline characteristics relapsing remitting multiple sclerosis patients methods expected calculated patient based age disease duration sex baseline expanded disability status scale lesion volume entering variables multiple regression model run patients pooled population according difference observed patients classified low medium high evaluated whether categories clinically meaningful assessing correlation disability worsening results distribution differences observed used categorize patients low medium high taking high group reference hazard ratios hrs year disability worsening adjusted treatment effect confidence interval medium low predictive value groups preserved years treatment effect appeared evident low patients medium high patients however difference significant conclusion patients categorized disability risk groups based individual values according baseline demographics clinical characteristics
although relation memory fairly studied less known regarding contribution relation three experiments investigated influence memory single context first experiment responses indicated superior recognition expected unexpected targets major context moderately expected targets importantly support previous work false memories responses also revealed higher false alarm rate expected unexpected targets results indicate roles memory second experiment utilized minor weakened since minor represented three forms simultaneously finally abolished entirely third experiment use accordingly expectancy based results observed first experiment disrupted second experiment disappeared third experiment results discussed light schema theory expectancy classic memory work availability heuristics
schizophrenia chronic debilitating neuropsychiatric disorder affects population binding protein one research domain constructs associated cognition significantly reduced brain schizophrenia patients understand molecular underpinnings pathogenesis schizophrenia performed microarray analyses knockout mice found genes involved pathway suppressed moreover discovered maturation master transcriptional regulator lipid synthesis regulatory element binding protein induced neuronal activity required induction immediate early gene arc activity regulated cytoskeleton associated protein necessary synaptic plasticity memory found nuclear dramatically reduced knockout mice postmortem brain tissues human patients schizophrenia furthermore activity dependent maturation arc expression attenuated knockout mice deficits restored atypical antipsychotic drug together results indicate important role neuronal activity induced arc related cognitive deficits schizophrenia
wide spread monitoring cameras construction sites provide large amount information construction management emerging computer vision machine learning technologies enables automated recognition construction activities videos construction activities construction workers strong impact productivity progress compared machine work manual work subjective differ largely operation flow productivity among different individuals hence work studies vision based action recognition construction workers lacking publicly available datasets one main reasons currently hinder advancement paper studies worker actions comprehensively abstracts common types actions kinds establishes new real world video dataset instances action recognition cutting edge video description method dense trajectories applied support vector machines integrated bag features pipeline action learning classification performances multiple types descriptors oriented gradients optical flow motion boundary histogram combination evaluated discussion different parameter settings comparison state art method provided experimental results show system size descriptor achieved average accuracy worker action recognition state art result elsevier ltd rights reserved
large multi institutional groups collaborations scientists engaged nuclear physics research projects number research facilities collaborations rules produce large number highly cited papers multiple nuclear physics publications creates problem assessment individual authors productivity relative colleagues renders ineffective performance metrics solely based annual publication citation counts many institutions increasingly relying total number first author papers however approach becomes large research collaborations order authors concept fractional credit one individual helps clarify issue providing complete picture research activities present work nuclear physics fractional total investigated using nuclear data mining techniques historic total fractional extracted nuclear science references database current range fractional contributions deduced results study implications discussed conclusions presented
objective examine associations categories psychological resources life satisfaction positive affect personal growth purpose life adjustment among japanese adults question important given increases rates type diabetes japan recent years combined fact prior studies linking psychological resources better physical health utilized western samples method data came japan study involving randomly selected participants metropolitan area subsample completed biological data collection female age years hemoglobin outcome models adjusted age gender educational attainment smoking alcohol chronic conditions body mass index bmi use medication negative affect results purpose life beta associated lower beta associated higher fully adjusted models comparable effects bmi standard deviation change associated change conclusions associations among psychological resources mixed healthy evident among japanese adults higher levels purpose life lower levels thereby extending prior research united states results emphasize need considering sociocultural contexts psychological resources experienced order understand linkages physical health
routing algorithm design chip networks become increasingly challenging due high levels integration complexity modern systems chip inherent components embedded blocks fine grained voltage frequency islands management among others raise several challenges network topologies become irregular asymmetric making circular route dependencies lead hard detect routing algorithms lack strong load balancing properties often order address aforementioned load balancing problems propose traffic balancing routing algorithm two phase routing algorithm consisting construction weighted channel dependency graph efficiently maximize available resource utilization channel ordering across turn models keep underlying cycle free guarantee freedom using one turn models channel bandwidth utilization traffic balancing achieved static virtual channel allocation according residual bandwidth healthy links addition introduce work two schemes different granularity fault detection analysis guaranteeing order packet delivery assigning unique path flow extensive experiments demonstrate proposed routing methodology outperforms previous algorithms
background belonging family seed extract long used cosmetic ingredient effect however little known whether seed extract therapeutic effects keratinocyte associated skin inflammation methods present study investigated effect topical application ethanol extract seeds atopic dermatitis symptoms mice direct effect keratinocytes evaluated using human keratinocyte cell line results preliminary application markedly reduced house dust mite allergen induced skin lesions expression thymus activation regulated chemokine dorsal skin downregulated directly suppressed expression production cells conclusions results suggest topical application effective preventing onset ameliorating atopic symptoms keratinocyte associated skin inflammation suppressing production keratinocytes
setting smoking reported associated tuberculosis effect conversion remains matter discussion objective assess effects smoking smoking cessation treatment outcomes patients newly diagnosed iran design newly diagnosed positive patients included study smokers participated smoking cessation programme status evaluated end month treatment smoking status evaluated end month differences conversion rates compared three groups non smokers smokers results total smokers non smokers included smoking cessation assessed months smokers found quit cure rate end months precisely compatible conversion rate significantly higher among non smokers months among smokers respectively conclusion cure rates patients newly diagnosed pulmonary higher non smokers months smokers smoking cessation advice included control programmes
background adults disease often report persistent fatigue even appears controlled unknown reasons aims evaluate common indications testosterone panel testing prevalence low testosterone methods case series determined common indications checking next conducted case control study compare healthy controls compared mean total free based histologic disease activity finally assessed tissue subjects obtained national health nutrition examination survey results males tested common indications included osteoporosis fatigue low observed men osteoporosis fatigue case control study difference mean groups data showed difference mean subjects conclusions low occurs patients similar rate general population common presentations low mimic non responsive symptoms published elsevier ltd rights reserved
growing evidence suggests micrornas mirnas play key roles cardiac hypertrophy measure expression endogenous mirnas conducive understanding importance mirnas cardiac hypertrophy however current methods monitor endogenous mirna levels northern blotting quantitative real time polymerase chain reaction qrt pcr microarrays provide real time information mirna biogenesis vivo constructed mirna reporter imaging system monitor mir expression induced cardiac hypertrophy three copies antisense mir mir cloned untranslated region utr luciferase reporter genes control cytomegalovirus promoter mirna reporter system mir luciferase used positive control imaging mir expression meanwhile mir hypertrophy mouse cardiac hypertrophy induced stimulation measured qrt pcr furthermore used mirna reporter imaging system effect vitro vivo signals mir gradually decreased prolongation intervention vitro vivo overexpression mir observed cardiac hypertrophy markedly administration reverse upregulation mir effects furthermore knockdown mir markedly reverse activities vitro vivo however activity affected treatment study feasibility using constructed mirna reporter imaging system monitor location magnitude expression levels mir cardiac hypertrophy vitro vivo
propose fuzzy ontology human activity representation allows model reason incomplete uncertain knowledge relevant found missing previous proposed ontologies domain modelled resulting fuzzy ontology able model uncertain knowledge represent temporal relationships activities using underlying fuzzy state machine representation provide proof concept approach work scenarios office domain also make experiments emphasize benefits approach respect ontologies result demonstrate inclusion fuzzy concepts relations ontology provide benefits recognition process respect approaches elsevier rights reserved
myeloproliferative neoplasms characterized common stem cell derived clonal proliferation diverse mutated patients polycythemia vera approximately patients essential thrombocythemia primary myelofibrosis pmf pulmonary arterial hypertension major complication several hematological disorders chronic myeloproliferative disorders associated included group five etiology unclear multifactorial aim study screen philadelphia negative positive myeloproliferative neoplasm patients presence correlation allele burden also made review correlation allele hematological parameters comparing results others enrolled patients philadelphia negative myeloproliferative neoplasms patients enrolled study subjected laboratory imaging form liver kidney profile bone marrow examination abdominal ultrasonography echocardiography results revealed patients pulmonary arterial hypertension patients pmf patients patients correlation allele burden statistically significant correlation analysis allele burden parameters revealed statistical significant correlation age ldh diameter insignificant correlation pulmonary arterial hypertension prevalence study significant correlation jak allele burden study largest one knowledge studies association prevalence burden
important medicinal plant documented use treatment headache migraine reaching back middle ages roots used date treatment due effects addition wild type plants yellow red variant intermediate orange form recently found natural habitat secondary metabolite profiles roots leaves rare variants investigated compared wild type two flavonoids six flavonoid four novel methylated flavonoid five three identified alcoholic extracts leaves roots three variants high performance liquid chromatography hplc diode array detection mass spectrometry analyses detected red orange variety wild type effects metabolite profiles three varieties observed possibility discussed regulatory step biosynthetic pathway affected mutation thus triggering color polymorphism
objective determine difference physical activity levels one year unilateral primary total hip replacement data sources search performed july studies eligible inclusion presented preoperative one year postoperative measures physical activity patients undergone unilateral primary total hip replacement review methods article used measure physical activity pre one year post unilateral primary total hip replacement data using meta analysis confidence intervals appropriate critical appraisal skills programme cohort study checklist used assess quality evidence results citations studies selected nine studies analysed meta analysis eight studies analysed qualitatively quality evidence low moderate statistically significant difference physical activity pre post total hip replacement assessed using movement related activity mean difference percentage hours spent walking minute walk test exercise test conclusion statistically significant difference physical activity levels one year unilateral primary total hip replacement however low moderate methodological quality included articles taken consideration drawing conclusions
article uses lens explore experiences race gender sexuality class associated depression unmet need mental healthcare population women transgender gender people ontario canada survey collecting demographic information information mental health use mental healthcare services data everyday discrimination scale questionnaire depression completed people via internet paper june june bivariate regression analyses conducted assess group differences depression discrimination experiences predictors depression unmet need mental healthcare services analyses revealed race gender class sexuality corresponded significant differences exposure discrimination experiences depression unmet needs mental healthcare use interaction terms model identities exclusion contributed explained variance outcome variables everyday discrimination strongest predictor depression unmet need mental healthcare results suggest lower income race identities associated depression unmet need mental healthcare however discrimination factor contributes vulnerabilities future research build theory role structural discrimination promoting poor mental health barriers healthcare
background vitamin concentrations pregnancy important factors early development influence kidney function offspring examined associations vitamin concentrations pregnancy kidney outcomes school aged children study design population based prospective cohort study fetal life settings participants study performed among pregnant women children predictors vitamin blood concentrations measured early pregnancy median gestational age iqr weeks birth cord blood outcomes measurements median age iqr years measured combined kidney volume ultrasound estimated glomerular filtration rate based creatinine egfr egfr concentrations results observed higher maternal concentrations associated larger childhood combined kidney volume whereas higher maternal vitamin concentrations associated higher childhood egfr associations independent concentrations higher maternal concentrations associated smaller combined kidney volume lower childhood egfr association maternal concentrations childhood egfr largely explained combined kidney volume higher cord blood concentrations associated larger combined kidney volume lower egfr vitamin concentrations associated limitations observational study causality established conclusions findings suggest vitamin concentrations fetal life associated offspring kidney development however effect sizes small studies replicate findings assess causality consequences kidney health later life needed national kidney foundation inc
disseminated fungal infections due rare occurring exclusively immunocompromised patients report first case liver transplant patient chronic rejection portal thrombosis refractory septic shock despite antibacterial antifungal treatment empirical treatment patient died multiple organ failure subsequently examinations blood cultures bronchoalveolar lavage fluid urine positive identified mass spectrometry confirmed sequencing respectively resistant best treatment appears combination amphotericin amphotericin elsevier masson sas rights reserved
application terrestrial laser construction sites construction progress monitoring controlling structural dimension compliance growing markedly however current research construction management relies planned building information model bim assign accumulated point clouds corresponding structural elements reliable cases dimensions built structure differ planned model planned model available sufficient detail addition outliers exist construction site datasets due data caused moving objects dust order overcome aforementioned limitations novel method robust classification segmentation planar linear features proposed reduce effects outliers present lidar data collected construction sites first points classified robust principal components analysis procedure classified points grouped using robust clustering method method also proposed robustly extract points belonging flat without performing aforementioned stages order preserve computational efficiency applicability proposed method investigated two scenarios namely laboratory million points actual construction site million points results obtained two experiments validate suitability proposed method robust segmentation planar linear features contaminated datasets collected construction sites
cytogenetic molecular investigations chromosomes carried using silver staining followed staining order improve knowledge structure chromosomes pattern peculiar since two chromosomes single pair presented bands silver staining fish rdna probe localized rdna genes one telomere chromosome also fluorescent staining chromosomes whereas bands positive interestingly remarkable organizing region present making two chromosomes easily southern blotting fish assessed presence repeat ends chromosomes analysis showed males possessed chromosome larger amount rdna suggesting non inheritance two chromosomes
soft rock mass southwest taiwan significantly meets water due short period poor visible surface slopes rainfall low durability resistance causes geographical also erosion problems highway slopes area effective protecting slope contribute reduction surface erosion facilitate drainage slope surface rainfall incorporate high strength structure fight swelling stress preserve vegetation contribute slope stabilization study new slope erosion soil vegetation method applied slope southwest taiwan utilizes waste beams geotextile waste good preserving soil vegetation slopes mitigating slope erosion beams support weight vegetation soil filled geotextile prevents loss fine grain soil guarantees drainage slope heavy rainfall experimental results slope slope angle degrees showed protected slope improved condition vegetation
article reviews process dsm personality disorder proposal change developed challenged ultimately rejected dsm introduce radical changes inherently limited time allowed efforts within committee lack clearly identified scientific rationale inconsistent dialogue existing community experts nonetheless valuable steps taken establish better definition introduce dimensions identify steps needed future author concluded borderline personality disorder antisocial personality disorder treated differently clinical significance empirical support specifically major remain axis secondary disorders belong axis
background increasingly used oncology syndrome represents adverse effect drugs becoming common nevertheless information regarding predisposing factors prevention therapy syndrome still lacking patients methods women received part regimen adjuvant treatment breast cancer retrospectively identified records oncology department data demographics disease adverse effects treatment reviewed patients divided two groups developed treatment develop syndrome two groups compared identify risk factors effectiveness drugs used evaluated results sixty seven patients identified fulfilling inclusion criteria nineteen patients developed first administration forty eight patients develop syndrome three patients group excluded taking time administration another indication remaining patients constituted control group two groups similar age menopause status stage cancer histology group higher median body surface area likely receive less three intended cycles anti inflammatory drugs atypical extended corticosteroids opioids drugs used treatments conclusion associated adverse effect causing incomplete drug treatment possible risk factors effectiveness treatments syndrome presented
recent studies demonstrate veterans exhibit higher suicide risk compared general population prior suicide attempt documented predictor suicide death despite increased attention clinical risk factors suicide efforts develop psychosocial interventions reduce suicide risk underlying biological factors confer risk understood study examined affect modulated series neutral pictures sample matched veterans low passive high risk active single multiple suicide based columbia suicide severity rating scale exploratory aim involved longitudinal component subset high risk sample went participate randomized month clinical trial investigated whether baseline predicts subsequent suicide attempt month follow compared three groups multiple showed greater pictures deficient overall early later trials groups differ neutral pictures self reported picture valence greater pictures associated greater emotion dysregulation measured difficulties emotion regulation scale future suicide attempt assessed prospectively month follow findings suggest pictures multiple suicide promising biomarker suicide risk underscore clinical importance targeting emotion dysregulation treatment patients risk suicide
background healthcare providers generate huge amount biomedical data stored either legacy system paper based format electronic medical records around world collectively referred big biomedical data realize promise clinical use research essential step extract key data elements unstructured medical records patient centered electronic health records data elements objective introduce novel solution known double reading entry system extracting clinical data unstructured medical records creating semi structured electronic health record database demonstrate reproducibility empirically methods utilizing modern cloud based technologies developed comprehensive system includes multiple subsystems capturing clinics transferring storing managing cloud based facilitating machine learning manual reading performing iterative quality control semi structured data desired database evaluate reproducibility extracted medical data elements conduct blinded reproducibility study patients undergone surgical treatment lung cancer china study uses kappa statistic measure concordance discrete variables uses correlation coefficient measure reproducibility continuous variables results using demonstrated feasibility extracting clinical data unstructured create semi structured patient centered electronic health record database reproducibility study patients shown overall high reproducibility varies across six modules pathology radio therapy clinical examination surgery information medical image general patient information conclusions uses double reading double entry independent manually structured data elements unstructured clinical data distributed computing strategies protects data privacy dividing data identified modules finally internet based computing cloud enables many data specialists work virtual environment achieve necessary scale processing thousands within days hybrid system represents probably solution solve big medical data challenge
distinct regulatory signaling mechanisms exist cortisol brain derived neurotrophic factor bdnf influence secondary injury cascades associated traumatic brain injury tbi predict outcome investigated concurrent csf bdnf cortisol relationships patients sampled days severe tbi accounting bdnf genetics age also determined associations csf bdnf cortisol month mortality bdnf variants used create gene risk score reference previously published hypothesized risk mortality younger patients years hypothesized bdnf production secretion capacity variants group based trajectory analysis used create two cortisol groups high low trajectories bayesian estimation approach informed mediation models results show csf bdnf predicted patient cortisol group also moderated bdnf associations cortisol group additionally cortisol predicted month mortality mediation analysis bdnf predicted mortality cortisol acting mediator yielding mediation percentage mediation effects increased among younger patients bdnf interaction predicted mortality younger patients thus conclude month mortality severe tbi predicted mediation model csf cortisol bdnf suggesting regulatory role cortisol contribution tbi pathophysiology mortality particularly among younger individuals severe tbi based literature cortisol modulated bdnf effects mortality tbi related known hormone relationships neurological injury severity autonomic nervous system imbalance
social economic inequalities condom use adolescents reported previously also condom use declined last decade aim study describe trends use condoms setting trends differ socioeconomic groups boys separately girls aged years attending school analyzed data three annual surveys risk factors secondary students included representative sample population individuals previously sexual intercourse included study calculated adjusted prevalence ratios confidence intervals using robust poisson regression models prevalence condom use among boys among girls respectively decrease greater adolescents low socioeconomic level boys girls observed increase socioeconomic inequalities condom use adolescents highlights possible deterioration good sexual practices policies studied period
background incidence skin diseases children influenced hereditary social environmental factors objective study determine incidence pediatric university hospital northern greece patients methods reviewed epidemiologic data patients aged years referred outpatient clinic university hospital january december demographic data frequency various diagnoses various age groups studied results nine hundred forty children adolescents diagnoses included study females males frequent diagnoses dermatitis eczema viral infections disorders nail disorders vascular malformations psoriasis bacterial infections atopic dermatitis prevalent age groups accounting total study population remarkably high incidence various forms seen data conclusion atopic dermatitis frequent pediatric age groups viral infections disorders account significant proportion referrals high incidence study attributed due relatively small study population represent real incidence region low incidence study attributed fact severe cases referred hospital
direct tension pull test others practical situ test assess bond strength materials bonded concrete substrate relatively although method prescribed number variations seen practice affect uniform interpretation test method results particular hypothesized shear normal stresses introduced drilling process damage sample affecting results disproportionately depth cut study systematically investigated hypothesis aim providing improved guidance associated depth indeed method core drilling hand core specimens tested results compared additionally system applying controlled torsional moment specimens used quantitatively investigate effect force applied specimen preparation study also investigated effect using square hand core specimens observed reduced pull capacity exhibiting reduction mpa depth mpa depth respectively increased core depth although attributed present drilling process square specimens exhibited marginally lower capacity comparable round specimens similar increased reduction capacity mpa depth cut finally discussion implications interpretation pull test results presented
aim study analyze preventative actions relation child morbidity using information regarding iron vitamin supplements recorded childrens health study used quantitative approach performed family health units city sampling convenience childrens health data collected observing analysis simple statistical highest percentage children vaccination date aged months records relating iron vitamin supplements others records one supplements administered vaccination status children first year life found satisfactory however discrepancies observed recordings administration iron vitamin supplements monitoring performed child health care professionals study contribute discussions strategies aimed improving monitoring recording childrens health
paper aims explaining large scale energy intensive industries german iron steel industry period slow uptake major energy efficient technologies mid mid mid technologies increasingly implemented analyze underlying factors investment innovation behavior individual firms german iron steel industry better understand barriers drivers technological change paper gives insights decision making process energy efficiency firms helps understand policy affects decision making use mixed method approach first analyze diffusion three energy efficient technologies primary introduction today top pressure recovery turbine basic oxygen gas recovery coal injection derive uptake technologies national level level individual firm second analyze impact drivers barriers decision making process individual firms whether want implement technologies economics access capital barriers uptake expected payback period exceeds certain value company lacks capital investments seem happen even economically viable company access capital investments realized policy induced prices strengthened recent diffusion found indications limited number cases policy intervention driving factor technical risks information marginal factors cases site specific factors seem important site specific factors shape economics selected
objective purpose study present ankylosing spondylitis patient fracture dislocation got reduction fixation successfully surgical treatment methods year old chinese male years history admitted emergency department sensory motor disturbance hours due fall home fracture dislocation diagnosed personal history neurological examination ray mri results posterior cervical instrumentation fusion lateral mass meanwhile satellite rod placed stress lamina removed extra observed given patients history fracture dislocation site highly unstable combined anterior posterior fixation performed patient underwent open reduction internal fixation fracture anterior cervical crest bone grafting patient postoperatively neurological state recovered muscle strength upper extremities lower extremities although neurological improvement minor motivation increased pain neck disappeared conclusion surgical treatment patients unstable fracture dislocation performed successfully
article review intelligent robotic algorithm approaches propose novel neural network based approach nonlinear systems nonlinear systems represented nonlinear models linear differential inclusion state space representation utilized deal controlled systems stability conditions controller design representation derived based fuzzy parallel distributed compensation scheme employed construct global fuzzy logic controller blending local state feedback controllers time delay states exist nonlinear simulated example including chaotic disturbances given show feasibility proposed fuzzy controller design approach
objective relation food allergies eosinophilic established also contribute development however limited data support hypothesis objectives pilot study determine whether seasonal variation onset symptoms diagnosis whether variations correlate specific pollen concentration within new york city methods performed retrospective chart review identify pediatric patients new york medical center diagnosed sixty six patients identified excluded cases classified date initial symptoms date histologic diagnosis pollen counts certified new york city counting station percentage cases monthly compared results seasonal variation onset symptoms diagnosis highest number patients reporting onset symptoms july september diagnosed october december seasonal correlation peak levels grass pollen peak onset symptoms highest july september diagnosis peaked one season later conclusions study findings suggest correlation specific onset symptoms time diagnosis patients
immunosuppressive effects highly selective widely used alpha agonist stress management investigated vitro present study respiratory burst human neutrophils separated venous blood evaluated treatment escherichia coli stimulation effects five concentrations evaluated flow nitric oxide production nitric oxide synthase inos activity also determined using commercial kits results compared positive control responses respiratory burst without drug found significantly suppressed respiratory burst production inos activity stimulation coli dose dependent manner suppressive effects activity human neutrophils associated respiratory burst coupled production
lacking explicit knowledge sexual orientation gay people commonly assess likelihood another gay using term mix word gay radar suggesting one sense perceive set characteristics another signal shared minority status commonly mentioned exact criteria gay person uses employing little discussed drawing series five focus groups self identified gay men study explores physical visual energetic cues gay people consider employ specifically interview subjects often described triggered following elements physical presentation including voice interactions especially eye contact presence absence certain social norms kind energetic exchange
introduction strength knee procedures frequently diminished several years blood flow restriction training uses partial venous occlusion performing exercise induce muscle hypertrophy strength improvements purpose study evaluate postoperative therapeutic intervention knee methods randomized controlled pilot study comparing physical therapy without knee conducted patients underwent sessions supervised physical therapy subjects followed postoperative protocol addition additional exercises outcome measures included physical function measures knee osteoarthritis outcome score veterans item health survey strength testing bilateral ultrasonography used evaluate deep venous thrombosis results seventeen patients completed study significant increases observed group proximal physical outcome measures significantly improved group timed improvements greater conventional therapy subscales significantly improved group greater improvement seen mental component score group displayed approximately fold greater improvements extension flexion strength compared conventional therapy adverse events observed study conclusions study suggests effective intervention knee investigation warranted elucidate benefits intervention populations greater initial impairment
paper presents system compensate deformations flexible peripheral milling based piezoelectric actuators dynamic model compensation system formed based moved piezoelectric actuator compensate deformation induced cutting forces command signal actuator calculated measured cutting forces compensation system acting cutting force values flexible system reach corresponding values rigid model ensuring tool cutting nominal width cut model considers performance three subsystems interact machining process positioning system structural assembly flexible machining process parameter identification dynamic model experimentally obtained modal analysis system identification procedure cutting forces model take account deformation compensation instantaneous chip thickness width cut proposed compensation system main application machining small parts thin walls although methodology applicable larger parts elsevier ltd rights reserved
variant translocation gene large non coding locus adjacent myc long non coding rna now recognized cancerous gene amplified myc various cancers expression functional role colorectal cancer still addition reported long non coding rnas far discovered either cells tissues research long non coding rnas detection extracellular vesicles reported yet present study firstly investigated expression colorectal cancer specimens correlation expression myc related genes real time polymerase chain reaction isolated extracellular vesicles colorectal cancer cells medium differential detected expression extracellular vesicles using real time polymerase chain reaction targeting sirna transfected cells assay flow cytometry used evaluate cell proliferation apoptosis results showed expression tumor tissues higher normal tissues significantly correlated expression myc three myc regulating genes also correlated expression two associated transcript factors nuclear factor kappa specific enhancer factor reported first time long non coding rna successfully detected extracellular vesicles excluded cells expression level higher extracellular vesicles aggressive cell results also showed regulating expression myc expression suppressed cell proliferation inhibited cell apoptosis increased taken together findings implicated new oncogene amplified myc colorectal cancer tissues extracellular vesicles functionally correlated proliferation apoptosis colorectal cancer cells
design high stability voltage controlled current source cervical cancer detection applying electrical bio impedance spectroscopy presented circuit designed simulated fabricated tsmc cmos technology power supply proposed current source based self biased complementary folded cascode operational amplifier requirements medical electrical equipment international standard iec sinusoidal current peak amplitude accordance requirements specifications calculated meet mhz frequency range sinusoidal output current output impedance higher broken vertical bar mhz frequency post layout simulations run main results output current peak amplitude specified frequency range broken vertical bar load impedance values broken vertical bar output impedance mhz nominal current amplitude variations lower load range broken vertical bar broken vertical bar experimental result maximum non linearity full scale results performance adequate applications
cloud computing uses remote processing applications first appeared ten years ago cloud computing built research virtualization distributed computing utility computing web services reduces information technology overhead starting new business accessed anywhere one concepts used constructing cloud computing virtualization security risks specific cloud key drawback adopting cloud computing security since clients use someone cpu hard disk processing storing data paper proposes security framework secure virtual machine images virtualization layer cloud environment securing virtual machine image significant probably affect security cloud computing
previously reported sulfate expressed cartilage synovial junction required formation knee osteoarthritis examine mechanism underlying process examined role proliferation differentiation synovial mesenchymal cells using recently established mouse synovial cell culture method primary isolated mice knockout rescued perinatal lack osteogenic potentials examined compared control prepared wild type culture condition proliferation control showed similar rates proliferation expression cell surface markers however cultures cartilage matrix production mrna levels significantly reduced compared control reduced level mrna restored supplementation exogenous protein difference osteogenic differentiation control measured levels mrna induction ppar mrna levels significantly reduced compared control reduction ppar mrna levels restored supplementation required differentiation via regulation ppar gene expression osteogenic differentiation via orthopaedic research society
although women type diabetes experience normal transition menopause little information impact hormone replacement therapy glycemic profiles year old postmenopausal woman type diabetes admitted hospital due diabetic treated fluid replacement continuous insulin infusion thereafter glycemic profile maintained daily multiple insulin injections however glycemic profiles immediately deteriorated following administration progesterone hormone replacement therapy transient deterioration implies external progesterone lead deterioration glycemic profiles postmenopausal women type diabetes
present activities daily living needs precise assessment allow ecological patient specific intervention use diagnostic tools remains rare due difficulties implementing laboratory settings overcome difficulties serious games represent good surrogate method offers possibility functional setting safe daily living environment allows testing quantifying performances motivating way purpose study investigate potential new serious game based assessment tool examining cognitive validity real life tool eighteen healthy elderly controls participated study asked execute cooking activity serious game real life assessed using neuropsychological test battery results showed performance virtual cooking task associated multiple cognitive measures performances virtual task highly representative participants real life tool first step toward including ecologically valid measures comprehensive assessment healthy elderly controls help assesses elderly patients diseases alzheimers disease elsevier ltd rights reserved
study produces composite geotextile evaluates effectiveness used soil protection fibers high strength polyethylene fibers recycled polyethylene fibers grids made pet composite geotextiles tested air permeability tensile strength experimental results show ratio fibers resulting composite geotextile optimum mechanical properties tensile strength approximately strength approximately strength approximately air permeability around
following strategy similar used yeast yeast metabolic network obtained community approach systems biology developments towards genome scale metabolic model yeast yeast expanded reconstruction saccharomyces cerevisiae metabolic network salmonella community effort towards knowledge base mathematical model human pathogen salmonella recent paper community driven global reconstruction human metabolism described much improved community consensus reconstruction human metabolic network called authors include present ones made freely available via database http format http short analysis main findings suggests approaches able exploit availability model advantage
background hand dermatitis serious health problem healthcare workers range skin care strategies policy developed recent years minimise risk effectiveness cost effectiveness remain unclear evidence now suggests psychological theory facilitate behaviour change respect improved hand care practices therefore test hypothesis behavioural change intervention improve hand care based theory planned behaviour implementation intentions coupled provision hand produce clinically useful reduction occurrence hand dermatitis compared standard care among nurses working national health service particularly risk secondary aims assess impacts participants beliefs behaviour regarding hand care addition assess cost effectiveness intervention comparison normal care methods design conduct cluster randomised controlled trial hospital health boards universities student nurses previous history atopic disease hand eczema nurses intensive care units nurses intervention light sites managed according currently regarded best practice provision advice optimal hand care prevent hand dermatitis contact occupational health department early hand dermatitis occurs nurses intervention plus sites additionally receive behavioural change programme going active reinforcement messages enhanced provision cream impact interventions compared using information collected questionnaires standardised photographs hands collected baseline months follow addition assemble relevant economic data analysis costs benefits collect information various sources evaluate processes statistical analysis multi level regression modelling allow clustering site compare prevalence outcome measures follow adjustment values baseline principal outcome measure prevalence visible hand dermatitis assessed study dermatologists addition several secondary outcome measures assessed discussion trial assess clinical cost effectiveness intervention prevent hand dermatitis nurses united
aiming problem diagnose soft faults nonlinear analog circuits novel approach extract fault features proposed approach based distribution model first kernels circuit test kernels used obtain functions fault features extracted functions taken input data hidden markov model finally classification features using soft fault diagnosis nonlinear analog circuit achieved simulations experiments show method proposed paper extract fault features effectively improve fault diagnosis
derived cell infusion damaged shown effect improved better selection patients cell subtype isolated patients ischemic heart disease able support vessel formation vitro ability varies patients primary aim study investigate whether vascular supportive function impacts therapeutic potential goal improving patient stratification subgroup patients produced efficiently support vessel formation poor reduced levels proliferation increased senescence despite isolated manner similar able support vessel formation rodent model myocardial infarction poor limited effect compared efficiently supported vessel formation vitro work suggests patients provide cells suitable cell therapy assessing vascular supportive function cells used patients truly benefit cell therapy better suited allogeneic transplant regenerative cells precision medicine fashion reduce costs culture times improve clinical outcomes patient prognosis
methods valuable tools fast evaluation key performance indicators early phase conceptual process design design absorption columns operation minimum solvent demand represents sound indicator however difficult determine infinite number separation stages need considered instead suggested model exploits existence point identify operation minimum solvent demand existing concepts known equation pet news significantly outperformed novel model gradually refined desired accuracy integration stepwise procedure results reliable solutions model covers rigorous thermodynamics regarding phase equilibrium heat effects number components required performance method illustrated several case studies seven components american institute chemical engineers
thermodynamic characteristics formation base phosphate aqueous solution different values medium determined means titration process kinetics studied reaction rate constants formation different medium determined biochemical aspects binding phosphate stable compounds discussed
cocaine addiction growing health problem among complications highlights high prevalence mental disorders occurring abuse dependence psychopathological comorbidity varies according time consumption age patient early detection psychopathological disorders associated drug consumption necessary optimize health care improve prognosis main aim present study estimate prevalence characteristics psychopathological comorbidity population subjects seeking outpatient treatment cocaine use recruited subjects using cocaine nasal evaluated psychiatric research interview substance mental disorders semi structured diagnostic interview primary mental disorders induced drug population presented male mean age displayed pathological use cocaine years presence psychopathology associated higher number dsm diagnostic statistical manual mental disorders criteria substance dependence lifetime prevalence psychopathological comorbidity highlighting mood disorders followed anxiety disorders psychotic disorders showed antisocial personality disorder borderline personality disorder among mood psychotic disorders induced disorders frequent primary disorders prevalent anxiety
light determines distribution community composition biomass shallow lakes therefore vital determine critical underwater light climate thresholds degradation recovery study first proposed novel index defined ratio depth water depth measure underwater light supply underwater light environment lake large shallow lake characterized based index using field measurements collected years seasons sites distribution presence frequency number investigations identified divided total number investigations greater bay east lake investigations followed sites distributed east lake proportion coverage increased increase significant relationship observed sites region high nutrient concentrations serious water pollution better underwater light conditions required growth value regarded critical underwater light threshold growth lake region ranging usually covered sparse region vital recovery environmental management lake distribution obtained using modis satellite derived june october bay bay southern part lake regarded potentially crucial regions recovery perspective underwater light nutrient levels elsevier ltd rights reserved
examples lake diversity occur within largest lakes north america report lake first example small lake two lake lean morphology diet life history genetics examined demonstrate existence determine potential influence evolutionary processes led formation maintenance results showed deep water deeper body smaller head higher eye position greater deeper shallow water lean grew slower smaller adult size older mean age lean genetic comparisons showed low genetic divergence indicating incomplete reproductive isolation phenotypic plasticity differences habitat use deep shallow waters associated variation opportunities seems sufficient maintain two demonstrating important roles resource polymorphism lake expands previous explanations lake diversity large small lakes reproductive isolation presence gene flow associated strong ecological drivers published article contributed government employees work public domain usa
although hormones play fundamental roles prostate growth clinical significance completely clear aims present study assess whether testosterone serum sex hormone levels predictors benign prostatic hyperplasia prostate cancer verify whether prostate cancer associated low testosterone levels test association testosterone levels known prognostic factors prostate cancer consecutive patients benign prostatic hyperplasia prostate cancer testosterone follicle stimulating hormone luteinizing hormone prolactin levels tested correlated disease patients prostate cancer hormone levels also correlated known prognostic factors predictive value assessed age prostate specific antigen psa psa ratio psa density prostate volume serum sex hormone levels using multiple logistic regression analysis receiver operating characteristic curves considering sex hormones testosterone levels significantly lower patients prostate cancer testosterone levels appear independent predictor prostate cancer enhancing predictive accuracy testosterone levels seem associated known clinical prognostic factors study supports experimental findings testosterone levels predictor prostate cancer prostate cancer frequently associated low testosterone levels diagnostic work prostate cancer adding testosterone determination psa test improve predictive accuracy
nature based approaches flood risk management increasing popularity evidence effectiveness catchment scale spatially distributed upstream measures inconclusive however also remains open question whether certain conditions individual impacts collection flood mitigation interventions combine produce detrimental effect runoff response modelling framework presented evaluation impacts channel natural flood management interventions couples existing hydrological model new spatially explicit hydraulic channel network routing model model applied assess potential flood mitigation scheme agricultural catchment north united kingdom comprising various configurations single variety channel feature hydrological model used generate subsurface surface fluxes flood event network routing model applied evaluate response addition features additional channel storage approximately seen reduction around peak discharge although sufficient reduce flooding moderate events inadequate prevent flooding double peaked storm magnitude caused damage within catchment strategies using features specific catchment suggested order improve attenuation achieved applying nature based approach
article addresses classical fluid mechanics problem effect capillary action column viscous liquid analyzed quantifying time dependent length narrow channel despite several past studies rigorous mathematical formulation inherently unsteady process still unavailable existing works crucial assumption valid transient systems approximate theories use integral approach penetration described total force acting domain rate change total momentum however viscous resistance temporally varying condition assumed resistance created quasi steady velocity profile thus leading order error appears due approximation true variation time strong enough causing negligible transient deviation hydrodynamic quantities present paper proposes new way solve problem considering unsteady field unknown variable accordingly analysis applies expansion flow unknown time dependent amplitudes along unsteady intrusion length calculated system ordinary differential equations comparative exploration identifies situation integral approach rigorous technique based expansion also reveals two methods differ substantially short time dynamics initial stage asymptotic perturbation shows two sets results long time behavior way findings provide comprehensive understanding physics behind transport phenomenon
globally coastal waters emerged pool antibiotic resistance genes multiple antibiotic resistant microorganisms pathogenicity resistant microorganisms terms virulence genes made environment vulnerable current study underscores presence multiple antibiotic resistant pathogenic escherichia coli predominant faecal indicator bacteria surface water sediment samples famous recreational faecal randomly selected isolates characterized antigen antimicrobial agents genotyped polymerase chain reaction virulence factors isolates belonged different predominant indicating remarkable diversity furthermore generated profile revealed isolates multiple antibiotic resistant sensitive coli isolates exhibited resistance extended classes antibiotic resistance antibiotics comparatively less antibiotic resistance indexing indicated isolates rooted high risk source contamination preliminary findings revealed presence encoding genes specific coli toxin producing coli heat stable toxin specific coli pathogenic thus government authorities environmental planners create public awareness adopt effective measures coastal management prevent serious health risks associated contaminated coastal waters
background diarrhoea common problem affecting millions year creating large economic burden risk factors known guidelines exist assist practitioners prevent treat however data lacking regarding actual prescribing practices approaches used management study aims establish baseline identifies practice methods online survey created using tool developed test approaches pre travel management participate survey distributed early selected australian new zealand travel medicine centres electronic list international society travel medicine descriptive statistics analyses using chi square analysis two sided fishers exact tests significance used results three hundred sixty four completed partially completed surveys collected respondents countries approach antibiotic choice management four different clinical scenarios assessed analyses focused identifying significant differences approach according region practice professional background level experience responses clinical scenarios suggest uniformity recommended treatment strategies clearly mild severe disease greater variability moderate disease conclusions practice diversity discussion preventative techniques prescribing self treatment medications especially moderate disease evidence based guidelines address competing issues patient health morbidity risk colonization resistant organisms lead consistent antibiotic prescribing practices
study aims assess risk factors cardiovascular disease cvd determine association traditional biologic disease modifying anti rheumatic drugs risk cvd chinese rheumatoid arthritis patients cross sectional cohort patients hospitals around china established medical history cvd documented patients social background clinical manifestations comorbidities medications also collected patients cvd incidence compared non cvd controls patients cvd significantly advanced age long standing median disease duration often male deformity joints patients cvd also higher rates smoking rheumatoid nodules interstitial lung disease anemia prevalence comorbidities including hypothyroidism diabetes mellitus hypertension also significant higher cvd group contrast patients treated methotrexate tnf blockers lower incidence cvd multivariate analysis showed use protective factor cvd hypertension interstitial lung disease independent risk factors cvd study shows independent risk factors cvd include hypertension interstitial lung disease reduces risk cvd patients
neurological disorders include wide variety mostly multifactorial diseases related development survival function neuron cells single nucleotide polymorphisms snps extensively studied neurological disorders number instances linked disease risk factors gene recently shown associated number neurological disorders parkinsons disease autism study reported investigated association snps gene essential autism schizophrenia bipolar disorder bpd total patients controls using polymerase chain reaction restriction fragment length polymorphism pcr rflp method significant association observed two disorders whereas found associated autism bpd findings indicative differential association snps different neurological disorders
background known whether left atrial enlargement associated left ventricular remodeling asian subjects preserved ejection fraction therefore studied whether enlargement related ventricular remodeling hypertensive chinese elderly preserved methods data hypertensive chinese elderly age years consecutively included study results observed total patients increased size univariate analysis showed size positively related duration hypertension prevalence coronary heart disease atrial fibrillation thickness posterior wall thickness end diastolic end systolic diameter mass index right ventricular diameter aortic diameter meanwhile size inversely related relative wall thickness multivariate regression analysis showed enlargement positively related duration hypertension diameter conclusions left atrial enlargement independently associated longer duration hypertension remodeling hypertensive elderly preserved enlargement early sign remodeling hypertensive elderly
multiple sodium hydrogen exchanger isoforms expressed testes play various roles cell volume regulation intracellular regulation fluid absorption recently characterized family member detected cells humans mice great abundance immunohistochemistry current study male mice lacking expression despite intact male reproductive organs male mice smaller testes lacked age seen testis mice although male mice normal serum levels luteinizing hormone follicle stimulating hormone serum testosterone level significantly reduced mice decreased expression luteinizing hormone receptor testes small interfering rna transfected mouse cells silencing decreased expression luteinizing hormone receptor similar moreover loss function cells resulted luteinizing hormone receptor membrane distribution therefore male infertility mice least partially due disruption luteinizing hormone receptor distribution consequent low testosterone production leads cell dysfunction work identified novel role male fertility effect modifying luteinizing hormone receptor function
feature society process decision making achieve philosophy politics public eligible competent candidates leaders rapid development technologies network applications actively promoted globally social transformation period concept electronic voting derived major advantages electronic voting comparing traditional voting lie mobility strength electronic voting reducing large amount costs enhancing convenience public electronic voting allows completing voting internet climate location restrictions overcome also increased voting time reduced public development past three decades electronic voting presents outstanding performance theoretically practically nevertheless electronic voting schemes still completely open lures money threats people money threats confirm following instructions various methods factors appear results affecting quality fairness study project aims design electronic voting scheme actually free money threats fail furthermore electronic voting system based elliptic curve cryptography proposed ensure efficiency security ring signature applied reducing computing costs moreover project also focuses applying voting system mobile devices system efficiency security emphasized need participate simply complete voting smart phones computers automatically calculated verified results necessarily printed printing reduced manual handling method effectively reduce voting costs enhance economic efficiency
emerging evidence suggested genetic factor attributed major determinant complex pathogenic mechanism gestational diabetes mellitus related genetic study limited aimed investigate impact polymorphisms mirna binding sites mir binding snps risk chinese han pregnant women screened susceptibility genes extensively selected mir binding snps using four bioinformatics software taqman allelic discrimination assays applied mir binding snps genotyping patients controls total five potential mir binding snps selected results showed increased risk adjusting age additive model furthermore found significantly associate higher levels fasting plasma glucose plasma glucose lower fasting insulin concentrations decreased additionally correlation plasma glucose observed two mir binding snps increased susceptibility functional studies required confirm underlying mechanism study provided additional insights genetic pathogenesis
background japan hpv vaccine approved october became available non routine vaccine december routine free cost responsibility non routine left individual exceptional circumstances regional governments non routine case city high uptake rate individual non school based hpv vaccination obtained materials january city media decision adolescent girls city hpv project team hpv vaccination set health promotion center gain mutual consent hpv vaccination senior health professionals city officials head board education school health care teachers met several times cohort girls aged years individual girl april along information hpv vaccine conclusions april uptake rate girls aged years old dose vaccine registry managed health care system city success hpv vaccination program high uptake rates city good model nationwide hpv vaccination program started february elsevier ltd rights reserved
problems identity formation associated range psychiatric disorders yet mechanisms underlying problems refined specific diagnostic presentations require investigation present study investigated identity processes among women eating disorders age matched community controls via newly developed identity model several clinical outcome variables assessed patients scored lower identifying identity related choices scored higher maladaptive exploration identity diffusion identity disorder also experienced less identity achievement compared controls identity disorder status associated highest scores anxiety depression borderline personality disorder symptoms non suicidal self injury lowest scores need satisfaction results indicate patients experience identity problems community controls captured identity disorder status experience problematic psychosocial functioning copyright john wiley sons ltd eating disorders association
background low income diverse older adults greater health risk owing lower activity levels potential cultural barriers physical activity programs explore specific barriers promoters enrollment week chi program interviewed lower socioeconomic older adults multiple ethnic backgrounds initiation program method semistructured qualitative focus group interviews conducted questions focused themes barriers promoters enrollment program culturally gender related results important issues emerged covered six categories categories included physical mental health time day socialization program pairing accessibility appropriate leadership teacher conclusion information value tailoring future programming community lead improved health outcomes better enrollment increased participation exercise
virtual reality started years ago form recognize today stereo head mounted display head tracking computer graphics generated images although hardware completely different emerged based different generation hardware displays rather vector electromagnetic tracking instead mechanical reached attention public many engineers scientists business people beginning new era soon change world better disappeared public view dead years huge amount research nevertheless carried across vast range applications medicine business psychotherapy industry sports travel scientists engineers people working industry carried research applications using exploring different forms knowing actually topic already passed away purpose article survey range applications evidence least debate utility mainly based publications peer reviewed journals course every type application covered every scientific paper papers google scholar particular review covered applications psychological medical rehabilitation objective reader becomes aware accomplished evidence weaker stronger done start section outline major conceptual framework used understand happens people experience concept presence section review areas used science mostly psychology neuroscience area scientific visualization use education surgical training section discuss used sports exercise section survey applications social psychology related areas used light social phenomena used tackle experimentally areas studied experimentally real life conclude used preservation access cultural heritage section present domain moral behavior including example used train professionals medical doctors serious patients section consider used various aspects travel collaboration industry section consider mainly use news presentation also discuss different types section briefly consider new ideas recently emerged impossible task since short time written page even newer ideas emerged conclude general considerations throughout possible stressed novel applications approaches real power necessarily produce reproduction reality rather offers possibility step outside normal bounds reality realize goals totally new unexpected way hope article provoke readers think paradigm advance realize different worlds positive impact lives millions people worldwide even help little saving
paper describes general model hybrid excited synchronous machine multiple voltage levels generated phase stator system voltage behind formulation different voltage level phase stator system realized machine design rotor excited excitation winding permanent magnet model incorporates magnetic saturation main inductance magnetic electric coupling phases field winding mechanical displacement angle cross coupling axes main included constant factor saturation levels turn ratio phase stator winding system another phase system also modeled constant value phase system iron core different weighting represented number turns relative reference stator system proposed model included field oriented control scheme simulations carried requested field winding currents demonstrate models dynamics results verified measurements test bench
atopic dermatitis defined chronic highly inflammatory condition skin estimated disease lead significant morbidity also adversely affects quality life atopic dermatitis responds home treatment proper skin care reduces need medicines topical oral used suppress symptoms clinical trial conducted patients control test taking written consent significantly improved skin symptoms associated safe tolerated specified age group patients overall results individual group analyzed using paired sample test level significance symptoms calculated drugs showed similar efficacy calculated value except case dry skin test drug shown significant value compare effects patients complaints test group shown better results side effects
aim present study assess changes thyroid function thyroid autoimmunity throughout ovarian stimulation sperm injection association changes outcome flexible releasing hormone antagonist protocol used women thyroid function assessed baseline five times days menstrual cycle day administration day day pregnancy test primary outcome measure change thyroid function throughout overall change recorded thyrotropin stimulating hormone tsh concentrations throughout women became pregnant increase tsh concentrations noted day pregnancy test compared day menstrual cycle respectively mean present women biochemical pregnancy negatively correlated changes tsh association noted regarding live birth rate present study provides evidence tsh concentrations increase especially women become pregnant
earth observation data great interest wide spectrum scientific domain applications enhanced access remote sensing images domain experts thus represents great advance since allows users interpret remote sensing images based domain expert knowledge however advantage also turn major limitation knowledge thus difficult shared understood users context knowledge representation techniques ontologies play major role future remote sensing applications implemented ontology based prototype automatically classify landsat images based explicit spectral rules ontology designed modular way order achieve generic versatile representation concepts think utmost importance remote sensing prototype tested four subsets landsat images results confirmed potential ontologies expert knowledge classify remote sensing images
syndrome due mutations genes structural regulatory proteins make complex considered disorder recently new phenotypes recognized expanding field multiple clinical issues facing individuals forms particularly neurodevelopmental system also gastrointestinal cardiac musculoskeletal aspects developmental cell biology found common endpoints biology complex improved understanding mechanisms easier diagnostic tests possibility potential therapeutics major clinical implications individual following abstracts presentations syndrome scientific educational june conjunction syndrome foundation national meeting addition scientific clinical discussions related practical aspects behavior including autism transitions communication access medical care databases end panel held included several parents affected individuals genetic discussed greatest challenges life information assist guiding future research research committee foundation meeting reviews abstracts subsequently information families members clinical board publications credits provided greater medical center
develop quantitative imaging biomarkers synovial tissue perfusion pixel based contrast enhanced ultrasound studied relationship synovial vascular perfusion frequencies pathogenic helper cells psoriatic arthritis psa joints eight consecutive patients psa enrolled study gray scale evaluation performed joint immediately joint aspiration automatic assessment perfusion data using new quantification approach pixel based analysis gamma model set parameters considered time intensity curve includes maximum value peak signal intensity curve blood volume index area curve auc contrast mean transit time mtt direct vivo analysis frequencies cells subsets quantified fluorescence activated cell cross sectional analyses tested multiple comparison setting false discovery rate common pattern correlations peak auc mtt parameters cells subsets lack correlation peak auc values cells observed pixel based assessment truly measure synovial inflammation useful tool develop quantitative imaging biomarker monitoring target therapeutics psa
background effects overt hypothyroidism pregnancy outcomes development established treatment protocol method material prevalence effects subclinical hypothyroidism pregnancy yet clear hence universal screening pregnant women still treatment detected sub clinical hypothyroidism yet general consensus data regarding beneficial effects treatment mother cases inadequate result known endemic area iodine deficiency reports occurrences limited study case series done detect prevalence pregnancy unit medical college hospital large population conclusion prospective study included screening pregnant women thyroid function follow cases till confinement record adverse effects thyroid dysfunction obstetric outcome
psoriasis common chronic inflammatory immune mediated skin disease antagonists tnf alpha recently proven highly effective treatment psoriasis however molecular mechanisms involved pathogenesis psoriasis poorly understood recently presented evidence kappa zeta key regulator development psoriasis role mediating driven effects like produced variety immune cells expression increased psoriatic skin purpose study characterize role regulation kappa zeta expression investigate whether regulates psoriasis associated genes human keratinocytes kappa zeta demonstrate stimulation induces kappa zeta expression mrna protein levels normal human keratinocytes moreover silencing kappa zeta sirna revealed kappa zeta key regulator specific inducible psoriasis associated genes proteins including addition induced kappa zeta expression mediated mechanism involving mapk kappa signalling pathways shown clear reduction mediated expression kappa zeta chemical inhibition two signalling pathways summary present kappa zeta novel key regulator driven effects psoriasis thus antagonists kappa zeta potentially provide targeted approach treating psoriasis treating inflammatory immune mediated diseases targeting drugs recently approved
objectives stress represent major problem operators committed proper smooth conduct therapies simple verbal approach enough common solution make use medications present work evaluates virtual reality system allow stabilization patients cardiovascular parameters consequent management stress materials methods non patients mean age years subjected ablation without use video one italy completion treatment patients pressure heart rate measured results conclusions statistically significant result obtained use combined audio video system audio music produce equally significant results preliminary study make possible observe use virtual reality system serves effectively stabilize even reduce cardiovascular factors related state stress studies needed confirm obtained results
article offers brief selective review important trends issues nonverbal research last years although volume range research increased dramatically period adequate integration extensive body work lacking response concern article proposes nonverbal communication framed terms adaptive efficient system managing social worlds several basic characteristics system outlined utility organizing facilitating research discussed
background linked intellectual disability common cause inherited cognitive deficit affecting mostly males several genetic causes implicated condition hampered establishment accurate diagnosis developed multiplex pcr assay mutational regions genes methods multiplex pcr validated cohort males selected include known alleles repetitive region five full mutations ten eighty five normal range sequencing southern blotting used confirm results depending allele class cohort exception one sample showing intermediate sized allele samples normal variant found besides validated assay applied samples males females results normal allelic range genes nature variants identified similar genders rate observed female samples alleles comparable published others two identified male female case several intermediate sized alleles one two putative full expansions male subjects seems relevant considering reported mutations found absence family history conclusions developed robust multiplex pcr used screen mutational regions genes moreover strategy led identification variants three genes representing improvement allele sizing also achieving differential diagnosis although distinction females truly homozygous second pre full mutation sized allele definitive diagnosis requires specific downstream technique use multiplex pcr initial screening cost effective approach scope detection
nitrogen levels modulate effectiveness resistance isolate host specific manner detected high low nitrogen effects altered caused one damaging diseases known affected nitrogen fertilization however genetic factors involved resistance characterized nitrogen limiting conditions study aimed assess variability resistance different nitrogen levels characterize impact nitrogen supply genetic resistance factors linkage analyses genome wide association study conducted detect resistance evaluate sensitivity nitrogen response set diverse lines derived cross resistant susceptible studied greenhouse high low nitrogen conditions following inoculation isolates resistance isolate controlled major small effects detected high low nitrogen effects altered resistance isolate greater low supply versus high supply new sources resistance found among low high conditions results discussed relative literature crop improvement perspective
analog signal processing current mode regime offers several advantages voltage mode counterpart although current mode circuits exhibit better noise performance fully differential topologies employed improve noise cancellation account common mode rejection properties paper presents fully differential first order low pass high pass pass filter sections operating current mode recently introduced digitally controllable differential voltage current conveyor chosen active building block filter characteristics digital control word demonstrated
popularity provided newer economic opportunities remote indian communities despite benefits offer acceptance mountain communities challenges qualitative research study given voice scheme non participants community members villages region thematic analysis rational reasons leading decisions engage identified socio cultural practical reasons include inability comply certain guidelines scheme infrastructure gender roles complex socio cultural issues also home model issues condition scheme implementation concept non participation advanced extends previous community participation theoretical practical implications study discussed along recommendations future development scheme elsevier ltd rights reserved
restrictive abortion law emergency contraception expensive available prescription easily public health care aimed identify main reasons requests observed failure rates type incidence adverse effects single center observational study cohort women living requested collected via questionnaire completed healthcare providers prescribing included age date request previous use time intercourse clinic visit day menstrual cycle intercourse took place main outcome request time unprotected intercourse use age women reported cases pregnancy resultsa total women requested old follow individuals became pregnant adverse effects hormonal rare mild main reason problems associated condoms mean interval unprotected intercourse use failed considering intake within difference significant living seeking used product soon unprotected intercourse probably one important reasons low pregnancy rates studied population
result peculiar features carbon nanotubes emerging many areas nanotechnology applications based technology increasingly proposed biomedical applications develop smart material tissue engineering purposes following chapter latter application explored describing considered ideal material able support boost growth proliferation many kinds tissues
innovation management falls short solving urgent societal problems power networks values constituent actors even though network business model innovation acknowledged innovation categories right problem solving potential remains unexplored article argue innovation requires considering shared values engaging innovation processes values understood subjective notions desirable values based innovation motivate development new networks business models address complex societal problems current forms energy supply present theoretical framework facilitation methods values based network business model innovation applied workshop regional energy networks germany reflecting upon lessons learned theory practice conclude crucial starting points systemic sustainability innovations found values based networks business models
parkinsons disease progressive neurodegenerative disorder basal ganglia patients suffer disorders system facilitates obtaining accurate information visual world target moves slowly parallel plane tracking eye movements occur consist primarily smooth pursuit corrective efficient smooth pursuit requires appropriate target selection predictive compensation inherent processing delays although pursuit impairment latency prolongation low gain eye velocity target velocity known normal aging alone results changes article first briefly review basic features smooth pursuit review recent results showing specific nature impaired pursuit using cue dependent memory based smooth pursuit task task initially used monkeys separate two major components prediction image motion direction memory movement preparation neural correlates examined major pursuit pathways patients possessed normal cue information memory extra retinal mechanisms pursuit preparation execution dysfunctional minority patients abnormal cue information memory difficulty understanding task patients normal cue information memory changed strategy initiate smooth tracking strategy changes also observed compensate impaired pursuit whole body rotation target moved head discuss pathophysiology comparing eye movement task results neuropsychological motor symptom evaluations individual patients results suggest possible neural circuits functions dysfunctions
plant extract mixture used present experiment containing previously shown decrease diarrhea mortality modify intestinal environment pigs weaning however results obtained among experiments consistent hypothesized dietary protein main factor determining effect plant extracts intestinal environment thus present study assessed effects diets different protein sources amounts pigs age allocated treatments followed factorial arrangement amounts fed basis diets various amounts protein sources diet contained low temperature fish meal level diet contained plus full fat soy level diet contained plus full fat soy level growth performance animals recorded differences detected among treatments eight pigs per treatment examine variables describing aspects gastrointestinal ecology diets containing tended decrease respectively decreased starch respectively also reduced length respectively tended decrease lymphocyte number respectively proximal inclusion also increased ratio decreased production diets decreased level appeared favor effects studied plant extracts positive negative way depending variable measured microbial differences produced reason improved digestive health observed authors stronger challenging conditions environments long fasting periods weaning
propose bayesian combination approach multivariate predictive densities relies upon state space representation combination weights several specifications multivariate time varying weights introduced particular focus weight dynamics driven past performance predictive densities use learning mechanisms proposed approach model set incomplete meaning models individually sequential monte carlo method proposed approximate filtering predictive densities combination approach assessed using statistical utility based performance measures evaluating density forecasts simulated data time series surveys stock market prices simulation results indicate set linear autoregressive models combination strategy successful selecting probability close one true model model set complete able detect parameter instability model set includes true model generated data also substantial uncertainty appears weights predictors similar residual uncertainty reduces model set complete learning reduces uncertainty macro series find models relatively large beginning recent financial crisis lower great moderation predicted probabilities accurately compare business cycle dating model weights substantial uncertainty attached respect returns series find investment strategy using combination predictions professional white noise model puts weight white noise model beginning switches giving weight professional forecasts time information complete predictive distribution just moments turns important turbulent times recent financial crisis generally proposed state space representation offers great flexibility combining densities elsevier rights reserved
multi task learning employs shared representation knowledge learning several instances problem multi step time series problem one challenging problems machine learning methods performance prediction model face challenges higher prediction due accumulation errors cooperative employs divide approach training neural networks promising single step ahead time series prediction recently evolutionary multi task learning proposed dynamic time series prediction paper adapt evolutionary multi task learning multi step prediction predictive recurrence developed feature knowledge previous states future prediction horizon goal paper present network architecture predictive recurrence capable prediction form multi task learning employ cooperative neuro evolution evolutionary algorithm comparison results show proposed method provides best generalization performance cases comparison results literature shown promising motivates application approach related real world problems elsevier rights reserved
engaging reflecting others thoughts beliefs feelings known facilitate later empathy prosocial behavior activation prefrontal areas shown predict extent prosocial behavior unclear however cognitive process drives effects simulation process mental states used proxy others self projection enhancement process ones perspective fmri study examined effects similar others behavioral brain measures empathy prosocial behavior assess cognitive process mediates effects participants two target persons one manipulated similar thoughts beliefs participant mental states assessed participants behavioral neural responses empathy pain task prosocial behavior task similarity participant target person increased empathy affiliation ratings persons evoked increased activation prefrontal cortex extent inversely related bias towards similar person empathy responses two regions also predictive later variations subsequent empathy prosocial behavior either predicting overall empathic concern lateral predicting reduced empathic bias towards similar person lower response self related stressors pain matrix areas medial pattern results suggests generating enhancing related representations overcoming ones perspective rather enhanced recruitment self projection processes driving effects later empathic prosocial responses elsevier rights reserved
paper describes methodology perform chemical analyses landfill areas integrating data used top approach identify environmental point interest based high resolution satellite data situ thermal surveys change detection techniques analysis supported chemical survey undertaken using accumulation chamber unmanned ground vehicle developed equipped sensor platform environmental monitoring approach improves site characterization identifying key environmental points interest necessary perform detailed chemical analyses elsevier rights reserved
providing healthy school environment priority child health aim study develop methodology allows quantification potential economic benefit reducing indoor exposure nitrogen dioxide children attending primary schools using environmental health data collected primary schools london study estimates average asthma exacerbations per school year reducing outdoor concentrations study expands upon previous analyses two ways first assesses health benefits reducing childrens exposure indoor school second considers childrens perspective economic evaluation using willingness pay approach study quantifies monetary benefits reducing childrens indoor exposure school range per school childs perspective based childs budget adopted parents perspective considered study highlights designers engineers policymakers stakeholders need consider reduction outdoor pollution particularly levels near primary schools substantial health monetary benefits published elsevier ltd
etiological diagnosis difficult task diagnostic tools establish definitive etiological diagnosis cases objectivesto verify diagnostic accuracy test etiological diagnosis caused streptococcus type paired fresh samples fluid children adolescents included investigation tested simultaneously bacteria sensitivity specificity predictive values likelihood ratios calculated taking reference standard resultsthe sensitivity specificity confidence interval confidence interval respectively whereas positive calculated bayes theorem negative predictive values respectively lower confidence interval positive negative confidence interval zero respectively results suggest useful tool etiological diagnosis reliable rapid simple perform shows excellent yield studied population helping prescribe appropriate antibiotics clinical condition
green real development one measures implemented reduce negative impacts building industry environment society economy however lack systematic review large number studies critical future paper reviews existing body knowledge related green development first common research themes green real development identified including concept measure business result green real development introduced four dimensions third stakeholders green real development benefits costs realize green real development current weakness analyzed various aspects found existing studies mainly focus environmental aspect green building dimensions sustainability green building especially social sustainability largely overlooked future research opportunities identified innovation evaluation systems integration planning design frameworks management mechanisms modes future elsevier ltd rights reserved
paper parallel high order envelope following method presented proposed method exploits high order stable formula provide superior accuracy speedup technique utilizing provides accurate faster analysis keeping accuracy conventional low order integration methods addition parallel method based multiple techniques used using allows partitioning solving sensitivity equations parallel also shown proper partitioning scheme high cpu scalability achieved
background cases sexual assault increasingly reported however researchers given adequate attention subject despite social physical psychological consequences study assessed survivors characteristics circumstances assault treatment offered view reducing incidence improving evaluation management methods retrospective review survivors case records state university teaching hospital january december data analysed using statistical software centre disease control prevention results new cases period sexual assault giving incidence among hospital consultations case notes sufficient information statistical analysis years knew majority occurred homes victims presented hours assault although daytime teenagers likely day non teenagers night threat physical violence mostly used overcome victims seventy three point six percent human immunodeficiency virus hiv screening one positive onset post exposure prophylaxis hiv given eligible emergency contraception post victims neither referrals psychotherapy forensic specimen collected record post assault conception hiv infection found follow conclusions adolescents remain vulnerable requiring life skills training protection survivors delay presenting care therefore public benefits early interventions comprehensive care survivors use standardized protocols recommended
subject reliability multiple phases since beginning late followed several programs including important one cracks travel short cracks company air force studies ultimately led series developments field reliability starting introduction fracture mechanics damaged tolerant design statistical framework estimation last decade various groups researchers studied reliability using model assisted simulation assisted applying bayesian statistics developments one objective improving accuracy life prediction components large extent depends reliability capability methods therefore essential reliable detection sizing large flaws components currently used studying reliability capability methods though data offers absolute truth regarding reliability system capability effects morphology quantifying human factors furthermore reliability reported alike meaning reliability subset reliability consists six phases samples selection using equipment setup calibration system measurement evaluation including repeatability reproducibility analysis variance anova system capability electronic physical saturation acquiring fitting data model data analysis estimation paper provides overview major last several decades discuss rationale using integrated computational materials engineering bayesian statistics studying controllable non controllable variables including human factors estimating another objective list gaps versus validated failed hardware
present algorithm efficiently compute accurate volumes surface areas graphical processing unit gpu devices using analytic model represents atomic volumes continuous gaussian densities volume molecule expressed means inclusion exclusion formula based summation overlap among multiple atomic densities surface area molecule obtained differentiation molecular volume respect atomic many body nature model makes port gpu devices challenging knowledge first reported full implementation model gpu hardware accomplish used recursive strategies construct tree accumulate volumes gradients tree data structures minimize memory algorithm used formulation surface area based non polar implicit solvent model implemented open source plug named popular library molecular mechanics modeling times faster best optimized implementation cpus achieving speeds excess day time step protein sized systems commodity gpus wiley periodicals inc
digital ulcers common visible manifestation progressive vascular disease characterizes disease process impact significantly patients quality life hand function also biomarker internal organ involvement disease severity aetiology digital vascular disease multifactorial many factors potentially amenable therapeutic intervention management disease multifaceted patient education non pharmacological interventions smoking cessation neglected number drug therapies available prevent type inhibitors receptor antagonists treat also important two reasons firstly primary end point related clinical trials secondly included classification criteria however reliability grade poor moderate best poses challenges clinical practice research purpose review provide reader description spectrum disease including pathophysiology epidemiology clinical burden inform multifaceted approach management
erosion wear unavoidable degradation process oil gas industry causes pipe wall thinning leads economic losses potentially produce personal injuries mechanism pipe erosion remains poorly understood study focused predicting erosion junction various flow types operation failure analysis junction determined macroscopic features scanning electron microscope sem images allowed definition failure mode failure mechanism defined appeared significantly different considered traditional failure analysis fluid mechanics theory used build computational fluid dynamics cfd simulation method predict erosion junction model two phase flow junction indicated solid phase flow determined combined effects main tube flow flow inertia turbulent flow distribution erosion significantly different various flow types simulation results consistent results failure analysis model predicted local distribution erosion wear assist monitoring pipe walls prevent accidents reduce maintenance labor elsevier ltd rights reserved
lack efficient agent disadvantage low activity acid high cytotoxicity poor skin penetration low stability formulation led continue research new agents therefore research natural products modulate metabolism great interest otherwise malignant melanoma one aggressive forms skin cancer high metastatic potential currently effective chemotherapy invasive melanoma therefore necessary develop new drugs potent activity weak side effects melanoma vitro anticancer effect analyzed melanoma cells using bromide assay effect isolated compounds melanoma cells investigated measuring amounts balb mice models inoculated mouse tumor cells used evaluate vivo potential assessing effect growth transplanted tumors antioxidant potential tested samples evaluated primary human keratinocyte cells using cellular antioxidant activity assay tested samples inhibited effectively growth melanoma cells vitro furthermore appears tested samples reduced inhibiting activity cells manner vivo studies showed total flavonoids extract treatment dose body weight days implanted tumor mice resulted significant inhibition tumor growth volume weight addition tested samples showed significant cellular antioxidant capacity reactive oxygen species primary human keratinocyte cells results indicate considered promising agent treatment melanoma shows antitumor activity vitro vivo moreover constituents shown highly effective inhibiting mediated vitro melanoma cells preventing oxidation cells without affecting viability normal human keratinocyte cells also used new candidate natural skin agents skin care products wolters kluwer health inc rights reserved
purpose paper aims examine effectiveness structural imaging aid diagnosis parkinsons disease methods high resolution weighted magnetic resonance imaging performed patients idiopathic mean age years healthy subjects mean age years whole brain regions interest using composite anatomical region volumes calculated three diagnostic classifiers constructed using binary multiple logistic regression modeling basal ganglion prior classifier data driven classifier iii basal ganglion prior data driven hybrid classifier leave one cross validation used evaluate predictive accuracy imaging features pearsons correlation analysis performed correlate outcome measurement using best classifier disease severity results smaller volume susceptible regions diagnostic parkinsons disease compared two classifiers basal ganglion prior data driven hybrid classifier highest diagnostic reliability sensitivity specificity accuracy furthermore outcome measurement using classifier associated disease severity conclusions brain structural volumetric analysis multiple logistic regression modeling complementary tool diagnosing
wireless sensor networks commonly used critical security tasks intrusion detection protected based previous research paper present kind routing protocol based node convergence degree trust value named focus security routing algorithm design work process including cluster head establishment cluster collection transmission sensing information wireless sensor networks simulation results show protocol prevent malicious behaviour malicious nodes effectively
background characteristics primary headaches patients brain understood date aims study study conducted evaluate influence treatment intracranial pattern previous primary headache methods evaluated pattern headache patients suffered within one year rupture prospectively evaluated characteristics headache months sixty patients evaluated questionnaire headache applied time admission patients contacted months treatment complete study filling follow questionnaire headache results thirty seven patients headache rupture tension type headache migraine without aura nine migraine aura one nonspecific characteristics significant reduction frequency pain months patients migraine without aura reduction pain intensity period migraine aura migraine without aura conclusion reduction primary headache treatment brain
parameter identification important widely used process across field biomedical engineering however susceptible number potential difficulties parameter trade causing premature convergence non optimal parameter values proposed dimensional reduction method drm addresses issue iteratively reducing dimension trade occurs running subsequent identification processes within drm validated using clinical data optimize parameters widely used minimal model glucose insulin kinetics silico data optimize parameters pulmonary recruitment model results compared popular algorithm using monte carlo methodology methods afforded equivalent computational resources drm lower equal residual value tests run using minimal model actual patient data model drm attained significantly lower overall median parameter error values lower vast majority tests shows drm potential provide better resolution optimum parameter values variety biomedical models significant levels parameter trade occur elsevier inc rights reserved
aim study investigate appearance density distribution cells human stomach prenatal early postnatal development examined cells stomach immunohistochemistry embryos fetuses infants cells identified weeks gestation cells detected individually clustered within base first trimester presented separately within basal apical parts second third cells numerous first similar third similar gestation development detected weeks gestation showed highest level expression gland lower parts second trimester third trimester corpus findings demonstrated first time abundant expression cells receptors human prenatal development indicating role regulation growth differentiation human gastrointestinal tract elsevier inc rights reserved
one species anti oxidative anti cancer anti inflammatory anti diabetic anti obesity anti angiogenic anti activities recently demonstrated ability reduce induced atopic dermatitis symptoms mice study examined properties column chromatography hplc analysis chromatographic separation spectroscopic analysis compounds adenosine acid identified different fractions evaluation anti inflammatory activities using reporter gene assay mrna analysis compound found block luciferase activity induced kappa suppress mrna levels cyclooxygenase cox tumor necrosis factor tnf alpha therefore data strongly suggests compound acts one major principles anti inflammatory anti atopic dermatitis activities
dna vaccines offer many advantages anti tumor vaccine approaches due simplicity ease manufacturing safety results several clinical trials patients cancer demonstrated dna vaccines safe elicit immune responses however date dna vaccines progressed beyond phase clinical trial evaluation studies mechanism action dna vaccines terms antigen presenting cell types able directly present cross present dna encoded antigens activation innate immune responses due dna suggested opportunities increase immunogenicity vaccines addition studies mechanisms tumor resistance anti tumor vaccination suggested combination approaches increase anti tumor effect dna vaccines review focuses mechanisms action mechanisms resistance using dna vaccines information used improve anti tumor effect dna vaccines approaches specifically discussed context human prostate cancer disease dna vaccines continue explored treatments elsevier inc rights reserved
study simple selective method based magnetic separation technology presented extraction sas environmental water followed liquid chromatography tandem mass spectrometry method magnetic surface molecularly polymers super property high selectivity toward sas developed magnetic applied selective extraction sas environmental water extraction enrichment accomplished simultaneously single step simply mixture water samples characterized scanning electron microscopy fourier transform infrared spectrometry sample adsorption thermodynamics kinetics employed study adsorption mechanism matrix effect method evaluated calibration curves obtained analyzing matrix matched standards show excellent linear relationship concentration range limits detection range relative standard deviations intra inter day obtained range respectively proposed method successfully applied determine sas six environmental water samples sas detectable four concentration
objectives delays diagnosis occur complex regional pain syndrome define prospectively demonstrate novel tests measuring body perception disruption identify patients objectives study define validate tests identify prevalence positive tests patients chronic pain conditions assess clinical utility sensitivity specificity positive predictive value negative predictive value identifying within fracture cohort single teaching hospital prospective cohort study pain free volunteers patients chronic pain novel tests finger perception hand identification body scheme report five questionnaires brief pain inventory upper extremity functional index lower extremity functional index neglect like symptom questionnaire hospital anxiety depression score assessed multidimensional pain best performing tests prospective monitoring fracture patients showed fracture patients total finger abnormal report initial testing developed persistent pain formal diagnosis novel signs reliable easy perform present chronic pain patients significant clinical utility predicting persistent pain fracture group thereby allowing targeted early intervention
software systems tend become larger complicated functional requirements increase gradually software systems widely believed understood managed evolved easily software module clustering problems significant challenging problems software engineering whose primary aim obtain perfect structures software systems according predefined rules solve important design measure appropriately evaluate quality structures obtained far quality basic widely used conventional measure however measure consider global modules edge directions two modules therefore paper design new quality measure based similarity labeled automatically guide optimization algorithms find good partition software systems considers global modules edge directions systematically validate performance three optimization algorithms namely algorithm genetic algorithm multi agent evolutionary algorithm adopted optimize real world software systems varying sizes thorough comparison shows outperforms basic guiding optimization algorithms find meaningful module clusters software systems elsevier inc rights reserved
non technical loss occurs smart meter meter registers less electricity consumption actual consumed amount therefore utility becomes victim suffers corresponding economic loss literature many detection schemes proposed detect however far complicated existing schemes expect recently discovered new potential type variant called non technical loss smart grid multiple exist collaborate existing detection schemes detect since methods consider existing therefore distinguish one many paper propose detector detect proposed method quickly detect meter based recursive least squares identifying meter proposed scheme detect different using mathematical models experiments show method effective detecting elsevier rights reserved
usage frequency signals eddy current metal detector described paper main task researchers minimize false alarms account total alarms better discrimination performed distinguish mine metals firstly short theoretical background presented secondly experimental data measured search head metal detector presented detector excited frequency sine signals khz khz synchronous used signal processing various spheres different materials sizes placed open air used test targets without also presented comparison amplitude phase graphs polar graphs presented differentiate different objects basis polar graphs better identification discrimination different buried objects anti personnel undertaken
purpose whether environmental friendly buildings always healthy using lifecycle assessment lca methodology purpose paper investigate lifecycle relationship building sustainability environmental health impacts design methodology approach order achieve block classroom modelled aid software lifecycle global warming potential human health impacts analysed using green building impact estimator tools sensitivity analyses block classrooms carried varying building materials energy use pattern original typology lca performed seven alternative achieved variation building materials energy use patterns findings eight building study shows direct relationship human health impacts confirms sustainable building less tendency negative health effects building occupants wider environment green building terms materials energy use pattern healthier building becomes research limitations implications human health impacts evaluated measuring amount particulate matter produced buildings environmental impact evaluated measuring global warming potentials buildings throughout lifecycle study based impacts building materials energy use patterns entire lifecycle buildings materials used construction originality value study established positive relationship building human health impacts thus arguments relating relationship building sustainability health laid rest paper
background sports related injuries contribute significant proportion workload unit aim study identify incidence sports related injuries treatments required assess impact injury future sport retrospective review carried trauma referrals september august patient records reviewed following variables recorded age sex sport involved injury sustained mechanism injury treatment subsequent participation interval return study population included patients sports related facial injuries common sporting injuries follows football soccer sports common injury sustained complex fracture mandibular fracture occurred orbit fracture nasal bone fracture common mechanism injury heads followed face majority patients participation chosen sport mean interval weeks range weeks conclusions study identified significant number sporting facial injuries presented year total patients underwent surgical procedure management injuries study highlights need educate players regarding use personal protective equipment adherence rules sports
alpha volatile natural coating apple fruit oxidation products thought induce superficial apple cdna encoding synthase converting obtained using pcr apple fruit comparison sequence cdna gene registered genbank showed sequences shared high similarity nucleotide sequence homology deduced amino acid sequence southern blotting suggested one copy genome apple northern blotting showed gene played key role synthesis days removed cold storage room temperature expression gene influenced treatment mcp
article presents experiment people visual impairment voice controlled smart home using sweet home system experiment shows weaknesses automatic speech recognition addressed need better adaptation user environment users disturbed rigid structure adapt preferences surprisingly aspect introduced system senior participants inclined system despite aspects improve system favorably assessed participant related loss autonomy
background aims apple polyphenol contains abundant associated anti atherosclerosis cholesterol lowering effect aim study investigate whether apple feature therapeutic efficacy terms atherosclerosis whether efficacy due mechanisms cholesterol lowering effect methods eight weeks diet rabbits given normal diet another eight weeks normalize increased serum lipids level rabbits baseline group sacrificed stage control group subsequently fed normal diet eight weeks group day addition normal diet serum lipids aortic medial thickness examined aorta examined histologically molecular biology results aortic ultrasonography lipid accumulation area examined using staining significantly reduced group compared control group serum lipid profiles different groups immunohistochemistry showed significantly decreased staining oxidative stress marker significantly increased staining atp binding cassette member group western blotting pcr also showed increased expression mrna protein group conclusions study revealed administration causes regression atherosclerosis hold promise anti atherosclerotic agent elsevier rights reserved
aim aim study identify clinical features patients obstructive sleep apnea syndrome investigate impact continuous positive airway pressure treatment nocturnal urine volume materials methods study enrolled patients moderate severe apnea hypoxia index data collected serum brain peptide level international prostate symptom score quality life qol score overactive bladder symptom score international consultation incontinence modular questionnaire nocturia qol score sleepiness scale score frequency volume chart patients continued treatment months included analysis results total patients men women completed study mean age years night time frequency void significantly decreased treatment mean scores assessed qol significantly improved mean diastolic blood pressure significantly decreased treatment however significant change level treatment frequency volume chart hours sleep total nocturnal volume nocturnal index significantly improved treatment however volume mean volume night time change treatment conclusion treatment decreases night time urinary frequency reducing nocturnal urine production improves qol patients wiley periodicals inc
distinguished career made significant contributions across diverse array topics computer systems including operating systems multi core platforms virtualization technologies enterprise middleware high performance computing paper summarize legacy key research contributions general purpose gpu computing vision conceptualization implementation demonstration systems runtime methods gpus first class citizens todays future heterogeneous computing environments end contributions include novel scheduling resource management runtime specialization novel data management techniques support scalable distributed gpu frameworks
type iii synthase cdna corresponding gene isolated full length cdna containing open reading frame encoding amino acid residues long protein coding sequence gene interrupted three different gene structure type iii genes studied far containing one intron conserved site except recently cloned gene phylogenetic analysis revealed shares close relationship synthase group functionally diverse synthase like enzymes southern blotting showed three four copies gene genome expression pattern transcript determined northern blotting high expression levels detected old stems lowest levels found old leaves pattern strongly correlates accumulation major bioactive principles called hydroxy beta suggesting play important role biosynthesis
graphics processing unit gpu significantly increased computing capacity state art high performance computing systems paper presents novel gpu acceleration approach transient stability constrained optimal power flow one computational challenging tasks large scale power system applications enabled revealed two level decomposition parallelism reduced space interior point method gpus serve plug time consuming linear algebra operations solving enhanced multi gpu processing mixed precision iterative refinement technique efficiency solving greatly improved without existing algorithm framework numerical studies based series test cases indicate effectiveness proposed gpu based approach large scale problems
paper aims perform comparative analysis regarding testing results achieved experimental model counter rotating wind turbine rated power wind velocity experimental model consisted system two rotors opposite directions one rotor rotating direction counter direction one unique electrical generator adds rotation wind rotors ratio two diameters wind rotor slightly larger wind one experimental model provided three phase synchronous electric generator counter rotating power rpm type generator characterized reduced size increased rotational speed losses due movement transmission experiments wind turbine system performed wind tunnel situ location nearby city turbine installed paper focuses investigating operation system controlled test conditions real conditions wind changes velocity direction order determine effect variations wind turbine system tested different wind velocities wind tunnel free air stream situ testing performed also order validate results obtained experimental model counter rotating wind turbine system within wind tunnel noticed good consistency two sets experiments resulting procedure suitable applied designing wind turbine prototype
ability capturing unknown attacks attractive feature anomaly based intrusion detection surprising research topic represents one promising directions field network security work consider two different traffic descriptors evaluate ability capturing different kinds anomalies taking account three different measures similarity order discriminate normal network behaviour presence anomalies extensive performance analysis carried publicly available dataset highlighted proper choice relevant traffic descriptor similarity measure particularly efficient case unknown attacks attacks detected standard misuse based systems
experience childhood bullying now recognized significant psychological effects particularly chronic exposure victims bullying risk number psychiatric disturbances growing evidence suggests pathophysiological effects bullying forms trauma chronic stress create additional health risks review literature known sequelae bullying including psychiatric physiological health effects focus implications victim addition since now established early chronic exposure stress significant negative impact health outcomes explore implications research relation bullying victimization childhood particular examine aspects stress response via epigenetic inflammatory metabolic mediators capacity compromise mental physical health increase risk disease research relevant mechanisms associated bullying potential interventions decrease morbidity urgently needed
objective study create computer vision algorithms autonomous identification colour applying proposed methods automated production sorting system developed system used example combination conveyor systems case requires distinguishing objects many classes high rate flow objects order achieve proposed system operates colour features selection algorithm classifier training grouping voting reject option developed developed system used automated sorting line increase quantities sorted applied algorithms gave highest accuracy expert database consisting classes
aim study investigating protective effect oxidative stress composition analysis revealed contained six major phenolic compounds vitro digestion contents two decreased significantly contents four flavonoid increased addition found successfully suppress induced ros restore mitochondrial membrane potential inhibit mitochondrial membrane lipid peroxidation glutathione depletion interestingly protective effect induced oxidative damage enhanced compared fruits without digestion study revealed enhanced cell resistance capacity oxidative stress rather direct reaction overall results indicate provides potent protection induced oxidative stress elsevier ltd rights reserved
paper multi source geological remote sensing datasets used construct multi scale district scale geological models extract exploration criteria subsurface exploration targeting district china results indicate series region district scale controlled main forming formed regional events secondary district scale folds faults intrusive stock structure produced based thrust structure events bearing zones forming structures district scale scale normal faults crossed controlled space associated mineralization buffer distance forming hydrothermal deposits constrained faults buffer distance forming fault iii nine four targets identified subsurface district elsevier rights reserved
adapting application diverse dynamic domains required pervasive computing use satisfy people demand terms continuity services addition proliferation smart devices ubiquitous services motivate need quick development applications support people dynamic domains quick development often associated domain knowledge therefore target research raising level adaptation rapid application development dynamic domains paper present work improve formal definition domain knowledge applications created domain experts propose context based semantic framework ami used create dynamic domain models basis building applications framework domain knowledge described means meaningful context include terms operations resulting enhancement adaptation applications also present paper applicability framework describe dynamic domains context based services develop micro context aware applications negotiate context consume services multiple computational spaces
distribution cell paths two phase flow cell suspension porous medium important quantity chromatographic processes estimated cell tracking sequences three dimensional images suspension medium images acquired situ time resolved using radiation phase contrast contribution presents new method estimating path discrete positions estimation based appropriate discretization differential geometric formula space curve investigations performed alcoholic suspension silica gel particles partially open foam show shape inner surface foam considerable impact particle paths turns variance slow particle moving close surface half order magnitude smaller fast particles importance filter efficiency lay description estimation particle paths porous media observed situ time resolved chromatographic processes used separate cells specific type suspension mixture cells many chromatographic processes based filtering suspension inner surface filter medium modified way specific cells interact surface design filter important increasing efficiency chromatographic processes reason observe flow cell suspensions pore space filter based fast micro computer tomography distribution distribution second curvature cell paths flow cell suspension pore space important quantity chromatographic processes estimated cell tracking sequences three dimensional images taken time resolved using radiation low absorption contrast solid matter filter suspension flow cell suspension observed phase contrast experimental conditions image acquisition technique estimation described detail
objective describe medical services provided sexual assault patients emergency departments identify percentage hospitals always providing elements comprehensive medical care management methods cross sectional study conducted national sample hospitals item telephone survey assessed provision services sexual assault survivors accordance management included acute medical care comprising history physical examination acute long term crisis counseling testing prophylaxis emergency contraception counseling provision hiv testing prophylaxis primary outcome extent provision elements results overall emergency departments responded survey following components provided acute medical care crisis counseling management emergency contraception hiv management hospitals provided elements conclusion less one fifth hospitals provide comprehensive services sexual assault patients national program incorporating clinical guidelines funding sexual assault forensic nurse programs improve standard care provided emergency departments primary point contact acute care sexual assault survivors international federation gynecology obstetrics published elsevier ireland ltd rights reserved
health aspect daylight recent years whereas urban congestion buildings architectural design minimize daylight high energy performance buildings tend constrain people benefits daylight buildings urban building act established japan building standard law replaced protection life health property nation public welfare building standard law provides regulations sunlight restrictions height form buildings requirements daylight regulations gradually relaxed urban growth paper outlines historical changes japanese regulations standards sunlight example discusses challenges future development revision international standards sunlight especially inclusion criteria health
three studies examined people express negative implicit attitudes toward individuals near face study participants completed implicit association test expressed moderately negative implicit attitudes toward individuals one side neck study replicated study symmetrical suggesting negative affect processing fluency underlies implicit negative evaluation individuals near face study showed dissociation explicit implicit attitudes toward individuals near face negative implicit evaluation attenuated image objectively positive symbol implications displaying near face discussed
micro small scale thermoelectric generation modules able produce continuous noise free reliable electricity power using low temperature differences widely exist nature industry advantages bring great application prospects fields remote monitoring micro electromechanical systems mems medical apparatus smart management system often require power source free maintenance vibration work prototypical thermoelectric module pairs micro scale thermoelectric legs width height leg fabricated using low cost mechanical machining process process cutting main methods preparation thermoelectric pairs commercial materials fabrication electrode patterns fabricated module tested power generation properties hot side heated electrical cold side cold air temperature thermoelectric potential short circuit current maximum output power finite element method applied analyze heat transfer module test temperature difference heat flux simulated according output powers different temperatures calculated result relatively consistent compared test results
hiv aids epidemic provided one challenging problems treatment infectious diseases antiretroviral drugs made marked improvement controlling immunodeficiency state patients gained longevity concern lipid abnormalities came initial drugs produced form metabolic syndrome accompanied elevated plasma triglyceride concentrations furthermore drugs used control virus often metabolized manner lipid lowering drug therapy antiviral agents improved many experience managing lipid disorders added greatly ability control problems discussion conducted physicians involved management large cohorts patients hiv infection special interest reduction vascular disease risk national lipid association rights reserved
ruxolitinib therapy approved indication myelofibrosis myeloproliferative neoplasm associated progressive bone marrow fibrosis hematopoiesis although pivotal phase comfort studies included patients intermediate high risk indication includes patients intermediate high risk disease data recent studies confirm benefits ruxolitinib established comfort studies terms spleen size reduction symptom improvement also extend patients intermediate risk tend less advanced disease patients higher risk given disease modifying potential ruxolitinib therapy timely initiation ruxolitinib therapy improve patients current clinical status also lead better long term outcomes decision whether initiate ruxolitinib treatment based expected benefit risk ratio patient specifically considering potential adverse effects
background unintended pregnancy important public health issue developing countries like india association adverse social health outcomes emergency contraception safe effective way prevent unplanned pregnancy objectives study assess attitude practices need assessment emergency contraception among married women years urban area methods community based cross sectional study done urban locality central semi structured questionnaire used take interview eligible females results study subjects favourable attitude towards use emergency contraception future need arises association attitude age parity contraceptive usage study subjects ever used emergency contraception pill found common used study subjects practice found associated education contraceptive usage knowledge conclusion government health facilities first choice study subjects receiving information getting emergency contraceptive pills however emergency contraceptive pills health centres long waiting time government health facilities found reasons going government health facilities getting emergency contraceptive pills
rapid advancement wireless technologies distinct applications wireless sensor networks wsns evolving public private domains however wireless sensor nodes experience major challenges terms power supply computing capabilities bandwidth requirements data communication apart data confidentiality integrity suffer due various transmission errors caused channel noise channel bandwidth limitation weak signals limitation transmitting receiving devices different security attacks various researches conducted resolve issues integrated way nevertheless existing literature offer effective solution resolve issues hence paper proposes unique elliptic curve based cryptography along key exchange technique address issues experimental results show proposed technique consumes low power utilizes cpu time effectively offering better throughput low complexity enhances confidentiality producing higher effect entropy value existing techniques capacity generating higher signal noise ratio lower percentage information loss justify efficiency produce higher data integrity compared existing schemes literature
ability human brain escape now mind take functional problem solving dysfunctional cognition routes although proposed latter act mediator relationship stress cardiovascular disease functional dysfunctional forms repetitive thinking associated blood pressure reactivity magnitude however similar reactivity caused different physiological determinants differ risk cardiovascular pathology examine way hemodynamic profile extent compensation deficit total peripheral resistance cardiac output compensate determining reactivity functional dysfunctional types repetitive thinking fifty six healthy participants randomly underwent cognition mind problem solving induction followed min recovery period cardiovascular parameters continuously monitored cognition problem solving mind elicited increases similar magnitude however cognition characterized vascular versus myocardial profile compared mind problem solving consequence recovery impaired cognition compared two conditions given high vascular resistance delayed recovery hallmarks hypertension results suggest potential mechanism cognition act mediator relationship stress risk developing precursors cardiovascular disease
standard model particle physics anti fractional charges equal electrons charge large number experiments searching fractional charge particles using variety methods including ionization energy loss measurements collisions evidence found confirm existence free fractional charge particles leads confinement theory paper proposal search fractional charge particles presented based conservation law four momentum lorentz force law show power new strategy fully detector simulated signal sample mixed fully simulated background sample analyzed lower signal cross section limits discover sigma signal function mass estimated background analysis result shows comparison ionization energy loss measurements advantage strategy identify fractional charge particles without using theoretical empirical formulae calculate expected observation values
rationale despite substantial public interest recommendations promotion good sleep health exist educate health care providers general public importance sleep overall health objectives aim american thoracic society statement provide review current scientific literature assist health care providers especially sleep physicians making recommendations patients general public importance achieving good quality adequate quantity sleep methods members invited based expertise sleep medicine conclusions based empirical evidence identified comprehensive literature review clinical experience main results focus sleep health children adults including impact occupation sleep public health implications driving common sleep disorders obstructive sleep apnea insomnia statement also gaps research knowledge addressed lead new focused research priorities advance knowledge sleep sleep health conclusions good quality quantity sleep essential good health overall quality life therefore strong recommendation made implementation public education programs importance sleep health
frequent construction buildings civil works causes excessive waste energy natural resources generally accepted asphalt concrete mixtures made recycled concrete aggregate promotes sustainable construction however analysis identifies environmental increased consumption mixtures therefore increased consumption fossil fuels technical solutions limit content mixtures control control fraction used application emerging potential tools limit consumption made management point view also propose policy revision technical specifications adapt technical standards paper makes contribution joining engineering economic approaches order make proposals construction management using recycled materials economically feasible
background meet aims providing comprehensive coordinated care patient centered medical homes need coordinate services individuals substance use disorders yet addiction treatment organizations across united states provide services million individuals daily generally prepared work organizations often lack electronic health records objectives examine extent organizations formal linkages contracts identify key dimensions linkages organizations shared use electronic health records identify characteristics organizations environments associated linkages materials methods draw data nationally representative survey clinical organizations survey respondents results thirty eight percent patients across nation receiving treatment organizations linked contracts number increases states expanded medicaid patients non medicaid expansion states yet great majority linkages relatively weak include exchange patient information results multivariable analyses show larger publicly owned organizations located northeast states expanded medicaid coverage likely contracts conclusions without stronger linkages organizations development models integrate services individuals substance abuse disorders continue receive care
development organic materials visible light driven photocatalytic regarded one promising avenues solve environment solar energy utilization issue present one dimensional organic self assembled molecule type hydrogen bonding act robust effective photocatalyst organic pollutants degradation water oxidation visible light without apparent need added metal catalysts corroborate highly efficient stable activity photocatalyst attributed introduction terminal group leads defined stable type constructs internal electric field thereby resulting valence band enhancement migration separation efficiency photo induced charge carriers findings help development based organic materials applications environment protection water splitting elsevier rights reserved
pulmonary opportunistic fungal infection immunocompromised individuals difficult diagnose requires tissue biopsy generally patients undergo invasive lung biopsies describe novel technique case uncontrolled diabetes mellitus pulmonary disease convex probe ultrasound guided aspiration lung cavity wall showed classical histopathological picture establishing diagnosis infection real time minimally invasive technique minimal risk complications led early diagnosis prompt treatment appears novel diagnostic modality pulmonary minimal complications compared biopsy methods high complication risk
paper presents gait generation navigation algorithms autonomous self mobile robot platform capable changing configuration according surroundings robot capability due multiple degrees freedom structure board range sensing ability proposed gait generation navigation algorithms enable shape best suited pass obstacles presented moreover robot capability various type moving wheels walking like swimming like humans respectively multiple kinds coupled terrain navigation algorithm robot identify different kinds obstacles transform seamlessly performance tested various real world obstacles experimental results validate performance
computer graphics industry great demand cost time effective simulation rendering meeting acceptable level hardware based simulation rendering taken another degree low level details environment modelling peoples paper presents investigation find feasibility deploying degrees view using mobile platform case study first modelled modifications newtonian laws inclusion proxy agents speed control turning second tests experiments carried concerning preferred parameters agent improvement random movements capability collision avoidance finally investigation discussed proposed solutions handling degrees view mobile platform published future academy
background although many web based mental health interventions released actual uptake end users limited marginal level engagement end users developing interventions recognized important cause uptake problems paper offer improve user engagement aim stimulate discourse user involvement within field online mental health interventions methods shortly describe three different methods expert driven method intervention mapping currently used develop web based health interventions focus extent end user involved developmental phase additional challenges final lessons learned summarized recommendations provided results every method seems trade end users highly involved availability end users means become problematic end users less actively involved product less appropriate end user challenges consider funding active role technological companies time takes process results shorter development cycles conclusion thinking user centered design carefully planning involvement end users become standard field web based mental health deciding level user involvement one balance need input users availability resources time funding
location aware systems use location based ratings produce recommendations recently experienced rapid development draw significant attention research community however current work mainly focused high quality recommendations privacy issues lead problems privacy problems prominent service providers limited computational storage resources leverage cloud platforms fit tremendous number service requirements users paper propose novel framework namely protecting user privacy information including locations recommendation results within cloud environment framework historical ratings stored calculated allowing compute similarities encryption predict recommendation results based comparable encryption also theoretically prove user information private recommendation finally empirical results real world dataset demonstrate framework efficiently recommend high degree accuracy privacy preserving manner
one effective means minimizing large collisions hazards locate hazards away major activity centers reliable means activity centers landscape significant progress proactive infrastructure planning used bridge movement modeling develop population wide utilization probability surface within upper bay used locations individuals tracked global positioning system gps satellite analysis electrical network probability surface within proving ground military installation identify overlap power lines activity centers also locations attributed lines installation assess relationship mortality rates utilization probabilities areas high use relatively rare landscape area accounting estimated utilization electric lines along roads distributed away activity centers lines located within areas highest estimated use highly skewed lines overlapped activity centers mortality rates birds times higher along lines associated highest use compared lines associated lowest use suggesting estimated utilization effective proxy mortality risk associated electric line hazards majority high use areas delineated within study area existing electric lines utilization probabilities potential tool site specific infrastructure planning society
background number vectors rest contributes sustained residual malaria transmission endemic areas spatial thought create protective bubble within reduced ideal outdoor use study builds previous studies proved efficacy treated strips outdoor goal study modify strips practical attractive acceptable treated confer protection potential infectious people use bed nets especially early evening study conducted valley district south eastern results protective efficacy hand treated wall early evening outdoor malaria vectors measured human landing outdoor bars peak outdoor activity treated wall reduced relative rate confidence interval respectively addition significantly reduced exposure outdoor spp respectively conclusion locally hand treated wall readily acceptable confer protection outdoor malaria vectors early evening people resting outdoor social places bars additional research help support use items complementary interventions expand protection communities currently experiencing outdoor transmission borne pathogens
purpose research consistently shown organizational constraints lead behavioral reactions although many studies investigated personality variables moderators predictors considerably less research considered cross level moderators effects purpose paper draw several related theories test team climate cross level moderator organizational constraints interpersonal relationship design methodology approach data collected using paper pencil surveys employees nested within work teams teams employed various industries including healthcare insurance manufacturing engineering financial services findings results hierarchical linear modeling analyses demonstrated effect organizational constraints interpersonal varied significantly across teams addition positive relationship organizational constraints interpersonal attenuated teams high climate practical implications organizational constraints difficult eliminate many however results suggest developing positive climate teams help prevent behaviors associated experienced constraints originality value one first studies examine climate shared property team cross level moderator findings research contribute theories organizational behavior highlighting critical role variables levels analysis beyond individual
authors examined role moral respect childrens overt aggression subtypes proactive reactive aggression diverse sample year olds aggressive behaviors measured teacher reports peer assessed teacher reports children reported moral respect within interview procedure asked feelings respect toward hypothetical peers displayed relevant behaviors results revealed moral respect negatively related overt aggression proactive aggression subtype unrelated reactive aggression subtype authors discuss implications findings relation developmental research affective antecedents childrens aggressive behavior
cultures turkey prioritize individual family gender specific ways men maintain via toughness aggression control women women maintain men sexual religious beliefs support womens violence violence women therefore challenged understanding beliefs ideological correlates inform efforts hypothesized favorable system ideology strongly positively predict turkish womens versus mens beliefs whereas hostile toward women strongly positively predict turkish mens versus womens beliefs additionally due gender inequality embedded religious expected positively predict beliefs genders convenience sample turkish undergraduates women men completed ambivalent inventory religious orientation scale endorsement index regression analyses revealed hostile positively predicted womens beliefs whereas hostile positively predicted mens beliefs positively predicted beliefs genders unexpectedly strongly men women suggest promoting feminist interpretations help turkish women challenge beliefs
although theory suggests women frequently experience gaze many adverse consequences scant research examining nature causes gaze perceivers main purpose work examine gaze toward women via eye tracking technology secondary purpose examine impact body shape gaze elicit gaze asked participants women men large university focus appearance personality women presented women body shapes fit cultural feminine attractiveness varying degrees including high ideal shaped women large small waist hip ratios average ideal average average waist hip ratios low ideal small large waist hip ratios consistent main hypothesis found participants focused womens faces less appearance focused personality focused moreover found effect particularly pronounced women high average low ideal body shapes line hypotheses finally compared female participants male participants showed increased tendency initially exhibit gaze regarded women high average low ideal body shapes positively regardless whether appearance focused personality focused implications person perception theories discussed
personality disorder bpd characterized emotional instability interpersonal dysfunction features typically develop background insecure attachment traumatic experiences behaviour therapy proven highly effective reducing self harm improving emotion regulation whereby problems concerning social cognition also characteristic bpd need additional approaches based treatment examined pilot study effectiveness given adjunct compared alone inpatient sample bpd whereby measured using novel based task treatments highly effective reducing symptom severity combination superior reducing attachment improving affective based treatment combination improve certain aspects social cognitive skills attachment security compared alone although exact mechanisms led changes need studied practitioner points clinical implications behaviour therapy combined based treatment combination reduces self harm alone plus lead reduction attachment improvement affective short term combinations evidence based borderline treatments enrich psychiatric inpatient care therefore approaches deserve research limitations treatment condition therapeutically intense control condition study lacked follow assessment impact comorbid conditions treatment response taken account adherence approach measured
using longitudinal data fertility intention behaviour study year study analyses fertility intention behaviour women qualified two children psychosocial point view based theory planned behaviour theoretical framework fertility intention fertility behaviour reconstructed observing phenomenon micro level gap female fertility intention behaviour associated factors studied result shows given situation qualified two children according governments birth control policy faced choice whether second child people tend make decisions attitudes towards fertility subjective norms perceived behaviour control contribute significantly discrepancy fertility intention behaviour addition formation concrete birth plan major driving force translating fertility intention action
purpose antibodies programmed death receptor associated distinct immune related adverse effects aes meta analysis randomized clinical trials aims summarize current knowledge regarding toxicity profile agents methods pubmed search conducted february randomized trials needed least one study arms consisting monotherapy control arm containing anti therapy data analyzed using random effects meta analysis risk ratios heterogeneity across studies analyzed using statistics results nine randomized trials patients included meta analysis evidence significant heterogeneity studies pooled relative risk treatment related grade aes grade aes respectively favoring anti therapy versus standard care approach treatment related death patients treated inhibitors increased risk hyperthyroidism hypothyroidism grade pruritus also common among patients pooled absolute risks respectively conclusion approved inhibitors tolerated associated significant low risk severe treatment related aes increased risk thyroid dysfunction pruritus
data structures algorithms important foundation topics computer science education however considered hard teach learn usually model complicated concepts refer abstract mathematical notions describe complex dynamic changes data structures many students programming courses difficulties master required competencies skills especially introductory level literature different ways enhance learning programming deal important dropout rate recently games increasingly used education various fields hypothesize games potential important teaching tool interactive engaging activities improve student engagement motivation consequently learning end developing game teach basic algorithmic concepts algorithms aim initially investigate educational games developed used computer programming domain review level address aforementioned difficulties propose role playing game called based existing solutions incorporates new elements pre validation game novice students encouraging demonstrates learning programming enhanced playing
laparoscopic gained popularity leading bariatric procedure treatment morbid obesity due rising numbers bariatric surgeries neurologic complications become increasingly recognized aim examine biochemical hormonal factors associated neuropathy post thirty two patients included patients neuropathy group patients without neuropathy control group diagnosis made blood samples taken examine vitamin deficiencies hormones involved neuropathy significant difference bmi groups excess weight loss percentages post months levels within normal range higher vitamin levels significantly lower values respectively vitamin levels significantly higher copper levels lower significant difference response groups data showed post neuropathy associated lower levels vitamin copper plus patients older age vitamin significantly higher toxic levels associated neuropathy difference preoperative bmi excess weight loss percent year levels found larger data required validate results
present work analyzed effect three dimensional flow viscous incompressible electrically conducting newtonian fluid porous medium bounded two horizontal parallel porous flat plates transverse sinusoidal injection fluid stationary plate corresponding removal periodic plate uniform motion flow becomes three dimensional due injection velocity approximate solutions obtained flow field pressure skin friction temperature field rate heat transfer found cross velocity reduced considerably rise magnetic body parameter permeability parameter injection forward flow reverse effect observed backward flow increase found main flow velocity whereas increase magnetic body parameter shown exert opposite effect similarly shear stress due main flow considerably increased increase results show methods perturbation electrical network schemes provides excellent approximations solution nonlinear system high accuracy acquired knowledge study used designers control flow suitable certain application possible applications include materials processing propulsion thermo fluid dynamics boundary layer chemical engineering etc elsevier ltd rights reserved
background overt subclinical hypothyroidism common finding adult populations affected non alcoholic fatty liver disease currently sparse data available association thyroid dysfunction obese children adolescents objective study aims investigate association thyroid function test values metabolic risk factors population obese children adolescents methods total overweight obese children adolescents girls aged analysed subjects underwent ultrasound examination liver thyroid function evaluated laboratory determination thyroid stimulating hormone tsh total triiodothyronine total thyroxine levels included subjects either euthyroid subclinical hypothyroidism tsh normal thyroxine metabolic profiling included determination lipid status insulin liver function tests anthropometric parameters body mass index waist hip circumference documented results prevalence hepatic subjects significantly higher tsh levels without dividing tsh values univariate multivariate analyses adjusted age body mass index standard deviation scores stage puberty showed significant association hepatic conclusion taking possible variables consideration results show significant association hepatic tsh levels obese children adolescents mild thyroid dysfunction therefore role determining metabolic profile obese children adolescents
background widely accepted excessive drinking contributes health social problems considerable interest potential community setting health advice evidence suggests interventions pharmacists effective research interventions relating alcohol consumption primary care focused general practice although evidence exists efficacy pharmacy interventions little research date taken place aim study evaluate acceptability alcohol screening brief interventions women accessing emergency hormonal contraception community methods initiative whereby women accessed community asked complete audit questionnaire following consultation introduced primary care trust north east england evaluation incorporated three interviewing pharmacists implementation acceptability initiative interviewing clients identified low risk understand perceptions initiative conducting online follow surveys clients risky group evaluate impact initiative alcohol consumption contraceptive behaviour perceptions service results pharmacists attitudes towards screening generally positive although organisational obstacles providing service felt uncertain engaging clients conversation sensitive topic however clients report feeling happy talk pharmacist given advice clients felt pharmacist appropriate person carry alcohol screening advice conclusions feasible pharmacists carry screening brief advice customers find acceptable however pharmacist take service participation study low pharmacists providing screening health promotion services targeting different population groups alcohol screening successful delivery audit tool pharmacists obtain reliable responses specific client groups
study orthopedic surgeons rural regional southeast australia determine attitudes investigation management osteoporosis found believe follow regard osteoporosis important responsibility follow diagnosis management lies primary health care current communication systems poor purpose introduction investigation treatment osteoporosis minimal trauma fracture regarded sub optimal strong evidence benefit identifying treating osteoporosis discussion possible role orthopedic surgeons play management osteoporosis study surveyed orthopedic surgeons rural regional southeast australia determine attitudes investigation management osteoporosis role health professionals play communication coordination follow care methods survey developed prior orthopedic surgeons asking opinions general management osteoporosis roles responsibilities health professionals dealing osteoporosis following results responses received participants majority respondents important treat osteoporosis following less respondents felt responsibility initiate discussion treatment investigation felt coordination osteoporosis care good stated poor communication discharge mostly left hospital stated follow study shows many rural orthopedic surgeons believe follow regard osteoporosis important responsibility follow diagnosis management osteoporosis lies primary health care current communication systems poor
research presents study design rotary pig farm heat degree electrical generator designed rotary consisted two pipes lengths meters pipes consisted drying cooling pipe diameter meter power supplied two power motors power used hot air fertilizer initial moisture content examined three parameters varied study optimal condition drying rotary speed degree tilt angle air flow rate rotary speed varied rpm degree tilt angle set degrees air flow rate varied cubic meters per hour experiment result revealed condition degree tilt angle rpm rotary speed air flow rate cubic meters per hours optimal conditions drying fertilizer fertilizer reduced drying rate thermal efficiency energy consumption kwh capacity designed rotary day three times amount traditional drying method cost rotary payback period months
clinical evidence accumulating role microbiome contributing modulating severity inflammatory diseases studies organized various organ systems involved type study approach utilized whether investigators compared microbiome cases versus controls followed patients longitudinally antibiotics bacterial introduction review summarize clinical evidence supporting microbiome important mechanism onset maintenance inflammation
single root virtualization specification allows single express device physical function used multiple devices virtual functions virtualization system directly assigned virtual machine mode significantly improve network performance however mode compatible live migration essential capability enables many advanced virtualization features high availability resource solve problem design provides support ensure device correctly used applications implemented without modification operating systems drivers experimental results show effectively migrate memory state data loss applications live migration costs limited resources extra cpu core significant runtime overhead network performance fact since continue used pre copy phase offers network throughput times network latency lower compared solutions switch para virtualization mode live migration
preferential parameters aqueous binary mixtures ethanol glycol glycerol derived solution thermodynamic properties using method drug sensitive preferential effects mixtures preferential parameter negative almost water rich mixtures positive mixtures similar proportions solvents rich mixtures except water mixtures negative values also found mixtures hydrophobic hydration around non polar ethyl phenyl groups drug water rich mixtures play relevant role drug otherwise mixtures similar solvent compositions rich mixtures preferential due acidic behaviour drug
elucidation metabolism new therapeutics major task pharmaceutical companies great interest drug testing laboratories particular need determine presence absence drugs metabolic products urine test misuse compounds commonly vitro animal models used mimic human metabolism produce potential targets amounts allowing method development alternative route based electrochemical reactions drugs reported allow generation selected metabolites utility approach doping control purposes demonstrated novel class agents termed selective androgen receptor modulators derived drug candidate subjected metabolism major phase metabolite resulting elimination substituted phenol residue identified vitro experiments generated characterised using liquid chromatography nuclear magnetic resonance spectroscopy high resolution high accuracy mass spectrometry metabolite included routine doping control procedures based liquid chromatography tandem mass spectrometry served reference compound doping control specimens
red fruit intake investigated obese diabetic mice weeks animals fed diets dried control assessed obesity diabetes disease risk biomarkers results showed intake improved antioxidant status plasma interleukin fold control plasma levels total cholesterol low density lipoprotein cholesterol ldl higher group overall enhanced cell exerted intake due fibre study demonstrates vivo intake dose achieved human consumption protect diabetes induced oxidative stress elsevier ltd rights reserved
active medium pulsed volume generation iodine atoms experimentally simulated using chemical generator oxygen discharge understand feasibility pulsed oxygen iodine laser electrical generator oxygen
paper propose novel fuzzy inference system picture fuzzy set called picture inference system enhance inference performance traditional fuzzy inference system positive neutral negative degrees picture fuzzy set computed using membership graph combination three gaussian functions common center different expressing visual view degrees positive negative values synthesized three degrees picture fuzzy set used generate outputs learning including training centers scales parameters also discussed system adapted architectures fuzzy inferences experimental results benchmark machine learning repository datasets example control theory system examined verify advantages
need reducing pollution congestion energy consumption increasing interest light electric vehicles play important role scenario since cost effective easy use small footprint paper explores series hybrid electric concept vehicle characterized absence mechanical transmission connected generator electrically coupled battery pack electric motor increases degrees freedom assistance provided poses several challenges human energy management proposed vehicle equipped time power source human machine interface paramount vehicle controlled yield natural feeling dynamics level vehicle level paper obtained bilateral control framework paper discusses design control system along several considerations choice generator motor tuning controller finally extensively experimentally analyzed human loop setting considering cycling feeling energy flows
agent approved countries use inflammatory bowel disease ibd controlled clinical trials demonstrated efficacy safety rheumatic diseases ibd assess effectiveness safety ibd patients real clinical practice prospective observational study patients moderate severe crohns disease ulcerative colitis treated study performed one single center patients included naive switched anti tnf treatment reference infliximab efficacy safety assessed naive switched patients remission time switch months therapy switched patients remission time switch continued remission naive patients reached remission months switched cases patients remission time switch continued remission months naive patients remission rates months adverse events occurred patients months study efficacious tolerated patients
disturbances emotion regulation depressive symptoms common menopause transition reproductive hormone levels directly correlated depressive symptoms factors influence mood symptoms menopause study sought determine role metabolic function mood symptoms menopause association menopause status long term glucose load studied women across three menopause transition stages examining effects age hormones metabolism mood neural activation emotional discrimination assessed participants using behavioral functional mri measures negative emotion emotion discrimination hemoglobin assess long term glucose load found emotionally images activated emotion regulation amygdala cognitive association brain regions prefrontal cortex posterior cingulate temporal parietal occipital junction cognitive association region activity increased menopause stage women left junction activation postmenopausal women prefrontal cortex posterior cingulate junction activation negative affect associated decreased amygdala activation depression symptoms negative mood associated increased junction activation hemoglobin associated negative interpretation bias neutral images cognitive region recruitment emotion discrimination fsh levels indicating menopause stage associated negative mood age associated behavioral measures activation patterns emotion task results suggest interaction metabolic hormonal factors influence emotion regulation leading increased risk depression menopause elsevier ltd rights reserved
exposure protects development allergies early life years protection asthma farm milk exposure partially mediated regulatory cells aim study investigate critical time window asthma protective farm effect via childhood immune maturation assessed longitudinally years children farm reference children birth cohort flow cytometry peripheral blood mononuclear cells cultured acetate lipopolysaccharide lps stained high mrna expression treg associated cell markers measured vivo suppressive capacity effector cells cytokines assessed detailed questionnaires assessing farm exposures clinical phenotypes birth age years answered parents percentage stimulation expression vivo decreased age years lps high low farm milk animal stable exposure associated decreased lps stimulated treg percentage age years lps elevated lps stimulated treg percentage age associated increased risk asthma aor suppressed ifn less efficiently mrna expression associated cell markers decreased years age years decreased farm exposure increased within opposite age years immunological switch defines critical time window treg mediated asthma protection via environmental exposure age years
analysis sunlight solar potential requires data targeted scene authentic accessible much possible regard data real world scene acquired ground based laser comprehensive convenient thus potentially meeting requirement get accurate result offer automatic solution sunlight analysis paper proposes solar potential analysis method run directly ground laser scanning point clouds method simulates natural illumination sunlight hours solar radiation targeted scene specified period method first extracts region interest roi obtain targeted points compute solar position virtual light source propose control method acting roi constraint deviation point light source finally adopt generalized hidden point removal algorithm cast shadow obstruction roi besides experiments validate method results carried three different periods quantitative results case evaluated distance demonstrate advantage feasibility proposed method
studies awareness disorders alzheimers disease controversial methodologies objects awareness patients pathologic stage vary study aimed compare scores correlates awareness according stage disease assessment method methodswe compared mild patients mild cognitive impairment mci patients using patient competency rating scale patient caregiver report self consciousness scale rating scale patients underwent cognitive psycho affective behavioral assessments global cognition executive functions episodic memory anxiety depression measures matched age education gender comparable depression anxiety awareness scales differed cognitive variables using median split approach greater lower depression associated poorer awareness self consciousness scale respectively odds ratio greater plus lower depression associated poorer awareness scales self consciousness scale results evidence comparable awareness mci patients correlates affective behavioral cognitive independently assessment method
oncogenic mutations lead constitutive erk activity supports melanoma cell growth survival signaling known regulator tumor progression crosstalk signaling ras erk pathway much less explored show mutant melanoma cells abundance plasma membrane atpase isoform low baseline markedly elevated treatment mutant specific inhibitor line findings gene expression microarray data also shows decreased expression cutaneous melanoma compared benign inhibitor specific increases levels mutant melanoma cells suggesting mapk pathway involved regulation expression increased abundance plasma membrane enhances clearance cells entry moreover show treatment overexpression induce marked inhibition migration mutant melanoma cells importantly reduced migration expressing mutant cells associated marked decrease metastatic potential vivo taken together data reveal important crosstalk signaling mapk pathway regulation expression suggest previously metastasis suppressor new new results give researcher another way attack metastatic melanoma commonly mutated copy current therapies focus mutants search new target molecules authors looked calcium ion signaling system promotes cell migration invasion found mutant melanoma cells less plasma membrane calcium ion pump molecule treatment mutant inhibitor migration cancer cells furthermore overexpression reduced metastatic potential cells vivo study first show hinder metastasis
promising concept small range peak power less represented stroke direct injection spark ignition engine scavenging exhaust ports controlled piston external pump important issue addressed type engines compliance stringent rules pollutant emissions depends combustion patterns quality scavenging process latter generally hindered symmetry ports adopting rotary valve controlling flow set auxiliary transfer ports using piston pump delivering air power cylinder enhancing balance paper reviews design virtual engine rated rpm developed according mentioned concepts design driven cfd simulation using whenever possible experimentally calibrated numerical models experimental information derived similar projects particular care devoted characterize scavenging process flow patterns within cylinder ports analyzing influence rotary induction valve engine performance parameters predicted using established commercial software power gamma technologies cfd analyses carried means customized version code whole study conceived basis construction physical prototype power target virtually achieved light compact engine estimated weight without close coupled electric motor three way catalyst allows engine comply stringent emission regulations without relevant fuel efficiency furthermore engine work lean mixtures achieving minimum specific fuel consumption comparable current automotive diesel engine kwh excellent result due low friction pumping losses stroke engine combustion chamber capability charge
aim clone delta fatty acid gene functionally characterize gene vitro vivo methods reverse transcriptional polymerase chain reaction pcr used clone open reading frame delta fatty acid gene plasmids constructed transformed escherichia coli strain using method expression induction transformed saccharomyces cerevisiae strain using lithium acetate method expression induction northern blotting method used investigate effect temperature transcriptional level gene cerevisiae strain results recombinant plasmids successfully constructed transformed coli cerevisiae separately appropriate method induction found expression delta fatty acid genes coli cerevisiae appropriate conditions led production active delta fatty acid convert acid respectively acid detection vitro vivo conclusion cloning expression gene coli cerevisiae successfully completed press rights reserved
introduction psoriatic arthritis psa heterogeneous chronic inflammatory disease characterized wide clinical spectrum early diagnosis psa currently challenging covered literature extensively reviewed studies addressing topic area diagnosis psoriatic arthritis review summarize improvements diagnostic tools especially referral role patient history clinical examination laboratory tests imaging techniques getting early correct diagnosis commentary due heterogeneity expression psa easily either diagnosis psa taken account every time patient psoriasis family history psoriasis shows peripheral arthritis especially involving distal joints enthesitis magnetic resonance imaging ultrasonography useful diagnosing psa early particularly isolated enthesitis inflammatory spinal pain occur
although extensive research suggests attention deficit hyperactivity disorder adhd conduct problems symptoms oppositional disorder conduct disorder antisocial personality disorder contribute risk substance use symptoms increase risk substance use remains unclear given research indicates perceived peer tolerance perceived peer substance use affect substance use evaluated degree peer perception constructs mediated association adhd symptoms symptoms interaction share substance use alcohol use use illicit drug use participants college students female european american mean age years results indicated perceived peer use significantly mediated association adhd symptoms alcohol illicit drug use whereas perceived peer use mediated association symptoms alcohol use perceived peer tolerance significantly mediated association adhd symptoms use alcohol illicit drug use finally symptoms moderated indirect effect adhd symptoms alcohol use perceived peer tolerance low levels symptoms increases adhd symptoms corresponded increases perceived peer tolerance related increased alcohol use however high levels symptoms increases adhd symptoms corresponded decreases perceived peer tolerance associated decreased alcohol use implications findings discussed
purpose assess feasibility acceptability efficacy text message based smoking cessation intervention china design study design randomized control trial month follow assessment smoking status setting provinces china provided study setting subjects total adult smokers china used life tools participated phase smoking education via text message study included intervention high frequency text contact group received one three messages daily containing smoking cessation advice health education information low frequency text contact group received one weekly message smoking health effects information measures primary outcome smoking status months intervention secondary outcomes include participant perceptions intervention factors associated smoking cessation among participants analysis descriptive analyses conducted assess smoking status acceptability factors associated quitting assessed using multiple logistic regression analyses results quit rates high groups month month months months month month months months significant difference two groups intent treat analysis attitudes toward intervention largely positive conclusion findings suggest text message based smoking cessation intervention successfully delivered china acceptable chinese smokers research needed assess potential impact type intervention
background transition whole exome whole genome sequencing research setting routine clinical practice remains challenging objectives almost previous research specifically assessing interface designs functionalities software tools authors set ascertain perspectives healthcare professionals distinct domains optimal clinical genomics user interfaces methods series semi focus groups structured around professional challenges encountered clinical conducted clinical genetic general physicians results contrary popular existing system designs preferred command line graphical user interfaces better software compatibility flexibility clinical genetic desired overarching interactive graphical layout prioritize candidate variants system functionalities relevant user domain made accessible favored system capable retrieving consistent representations external genetic information third party sources collaboration patient exchanges authors identified user requirements toward automated reporting system capable summarizing key evidence based clinical findings among vast array technical details conclusions successful adoption clinical system heavily dependent ability address diverse among specialists distinct healthcare domains tailored software interfaces suitable group likely appropriate current popular one size fits generic framework study provides interfaces future intervention studies software engineering opportunities
approximately thyroid cancers thyroid carcinomas mainly sporadic nature cases hereditary genetic testing hereditary important patient family patients receiving appropriate genetic counseling patients hereditary germline mutations exons intron rearrangement transfection oncogene etiology frequent sporadic form understood recently reported apparently sporadic involve point mutations ras genes overall prevalence almost also alteration abnormal expression mirna described review attempted mutations molecular changes sporadic hereditary pathogenesis
auditory steady state response increasingly used biomarker neuropsychiatric disorders research investigating test retest reliability measure needed previously reported reliability measured electroencephalography eeg amplitude modulated white noise train stimuli purpose current study assess reliability measured amplitude modulated white noise train stimuli compare test retest reliability eeg measures previously investigated additionally impact stimulus parameter choice reliability assessed comparing responses white noise train stimuli test retest reliability across sessions approximately one week apart assessed healthy adults study day participants completed two passive listening tasks white noise train stimuli separate eeg recordings session correlations evoked power inter trial phase coherence assessed following source space projection overall measured significantly correlated sessions corrected suggesting acceptable test retest reliability results suggest greater response reproducibility compared evoked responses train compared white noise stimuli although study warranted significant differences reliability observed eeg measures suggesting similarly reliable work supports use biomarker clinical interventions repeated measures elsevier rights reserved
letter introduces efficient technique pulse compression dispersion compensation using microwave pulses propagating negative regime accomplish investigated wide cells thick using finite difference time domain method parameter extraction technique demonstrate controlling initial pulse association cell density geometry frequency response possible pulse factor also compensate pulse due dispersion
purpose review syndromes mds remarkably diverse somatic mutation patterns challenging interpret clinically yet genetic information increasingly available physicians review examine several implications genetic diversity mds recent findings somatic mutations serve clinically relevant biomarkers mds molecular subtypes exist share clinical features including risk progression acute myeloid leukemia response treatment overall survival several mutated genes known prognostic value independent common risk stratification tools mutations several genes identify low blast percentage patients greater predicted disease risk mutations predict lower disease risk expected mutations associated adverse features yet demonstrate inferior outcomes predicted risk factors mutations identify clinically relevant subtypes mds allow better refinement risk within groups using somatic mutations diagnose mds challenging occur healthy individuals yet patients unexplained high rate clonal hematopoiesis important risk factor identify clinically summary patterns somatic mutations diverse mds inform prediction prognosis aid diagnosis
paper proposed pid controller tuning method new equation state adding new integral element output variable pid controller design method using method order make robust stable control performance inverted pendulum system suitable evaluating effectiveness control theory due unstable strong nonlinearity research confirm excellent stability excellent control performance inverted pendulum system simulation inverted pendulum
background sequence variation gene promoters often associated disease risk study tested hypothesis common promoter variation gene associated systemic lupus erythematosus sle risk sle related clinical phenotypes chinese cohort meanwhile investigated expression apolipoprotein serum patients systemic lupus erythematosus sle relationship disease activity methods used case control design genotyped sle patients healthy controls promoter single nucleotide polymorphism snp genotyping done matrix assisted laser desorption ionization time flight mass spectrometry maldi tof blood serum concentration measured enzyme linked immunosorbent assay sle patients controls results average concentration serum significantly lower sle patients compared controls levels sle patients positive anti antibodies dramatically lower patients negative anti antibodies interesting levels correlated systemic lupus erythematosus disease activity index scores association sle susceptibility detected han chinese cohort conclusions results demonstrated lower levels sle patients correlated disease activity
paper describes algorithmic construction basic distribution formulas technique computation scale parameter help matlab parallel computing toolbox properties distributions derivatives demonstrated also graphical references applications data health environment introduced
background prevalence childhood trauma elevated among individuals severe mental illness compared general population associated poor prognosis substance misuse lower treatment compliance violence antisocial personality disorder aspd childhood adult onset also represent possible mediating mechanisms explain risk violence among men current study aimed explore explanatory pathway linking childhood traumatic exposure antisocial personality risk violent behaviour among adult male inpatients methods total male inpatients examined using cross sectional survey design information extracted medical files interviews official criminal records results fifty two participants reported experiencing childhood trauma group times likely engage violent acts within past months without history furthermore childhood onset aspd early likely report childhood trauma engage violence compared adult onset aspd late without antisocial histories multivariate analyses revealed early aspd variable independently predicted violence mediated relationship childhood trauma recent violent acts conclusions significant subset men reporting trauma antisocial conduct childhood early aspd considerably elevated risk engaging violent behaviours assessment antisocial men assist effective case resource allocation treatment planning elsevier rights reserved
research tried identify risk factors increase likelihood difficulties externalizing behavior relations individual environmental factors externalizing behavior especially documented child oriented parent oriented interventions designed order decrease externalizing behavior preschoolers date however research largely therefore known whether child oriented parent oriented intervention effective reducing externalizing behavior aim current study answer question comparing two week child two week parent oriented group programs sharing common experimental design done pseudo randomized trial conducted year old children displaying clinically relevant levels externalizing behavior assigned one four interventions control participants allocated waiting list results indicate four programs focusing specific target variable social cognition inhibition parental self efficacy beliefs parental verbal responsiveness effective reducing externalizing behavior among preschoolers effectiveness moderated neither orientation toward child parent content suggesting several effective solutions exist improve behavioral adaptation preschoolers second important highlight study thanks comparable effect sizes brief focused programs appear reasonable alternative long multimodal programs cost effective children families
background medial ligament injuries require surgical management uncommon growing evidence however suggesting incidence reconstruction procedures rapidly increasing sought quantify incidence age related trends subsequently project future trends hypothesized total number performed increased disproportionate incidence among younger patients observed methods new york states planning research cooperative system database identify individuals years old undergoing poisson regression used develop future projections new york state population incidence estimates per people calculated results new york state patients underwent average annual incidence per people ages years significantly greater age groups projections suggest incidence year olds year olds continue rapidly increase rates age groups remain relatively stable conclusions number performed increased disproportionate trend average annual incidence patients years old observed review literature questioned outcomes adolescent athletes continued attempts preventing injuries young athlete remain paramount journal shoulder surgery board
explore demographics clinical medication profiles patients social support perceived health status hiv patients china performed cross sectional study hiv clinic city peoples hospital health professionals conducted face face interviews collected data patients electronic medical records regarding patients demographic clinical medication information social support perceived health status classified hiv aids patients hiv ratio hiv patients hiv likely older male less educated carrying health insurance advanced stage hiv infection longer history hiv opportunistic infections patients also likely hold negative belief hiv treatment prevent exacerbations reported significantly worse emotional informational support social interaction perceived health status better social support better self efficacy hiv treatment adherence significantly associated better perceived health status among patients hiv hiv associated poorer perceived general mental health particularly undergoing therapy findings suggest need mental health referrals medication management individuals efforts policies improve coordinated care
recent years particular worldwide development optimization utilization biomass essential component biomass processing need robust high performance tools biomass synthesis new high value bio based chemical entities functional screening bacterial discovered open reading frames classified different hydrolase families eight family four two one families eight overexpressed partially characterized shown alpha particular interest discovered beta consisting catalytic domain two carbohydrate binding modules functions selectively bind insoluble increases rate hydrolysis primary structure showed classical catalytic acid residues generally forms part active site enzyme family optimal degrees generated various sources including wheat catalytic ability natural substrate wheat renders potential useful effective complex plant biomass architecture international union biochemistry molecular biology inc
fuzzy trace theory distinguishes exact meaningful representations predicting reliance increases experience expertise thus many judgment decision making biases increase development cognition colored context ways logical coherence probability theories nevertheless increase based adaptive stable less sensitive interference easier manipulate moreover captures functionally significant essence information supporting healthier robust decision processes describe fuzzy trace theory accounts judgment decision making phenomena predicting paradoxical arc processes development experience expertise present data linking memory processes processing decision making provide reliance medicine public health intelligence analysis report first evidence predicted link false memory framing biases risky choice society applied research memory cognition published elsevier inc rights reserved
paper presents digital active electrode system multi parameter signal acquisition portable wearable devices built around performs analog signal processing help chip instrumentation amplifiers bit adc digital interface via standard bus digital active electrodes channels connected commercially available microcontroller thus significantly reducing system complexity cost addition utilizes innovative functionally coupled amplifier preserve input signal still achieving state art performance input referred noise electrode offset tolerance common mode feedforward scheme improves pair maximum
new low molecular mass potent agent bacillus partially purified enzymology studied enzyme showed optimal temperature degrees enzyme found stable min incubation degrees inhibited group specific agents like sds metal ions whereas show significant inhibitory effect partially inhibited enzyme substrates specificity tests indicated enzyme showed relative activity glycol compared enzyme also acetyl indicating activity study broad specificity bond also related carbohydrates linkages partially purified showed antifungal activity two potent also increased seeds infected two potent fungi
wave digital filters class digital filters equivalent transmission line circuits synthesized uniform transmission lines order extend applications physical wave phenomena including quantum electronics necessary consider generalized distributed line whose velocity energy flow frequency characteristics paper discusses generalized distributed circuit obtain two types lines cut order analyze lines discuss signal flow graphs steady state voltage current reflection factors obtain active power element scattering matrix zero conjugate matching using reflection factor obtain band pass filters synthesized cut lines also describe analysis method line related differential equation
three rare earth containing center dot iii synthesized reaction center dot center dot aqueous solution characterized elemental analyses spectra thermogravimetric analysis powder ray diffraction single crystal ray diffraction molecular unit consists shaped two supporting one disordered cation viewed combination two subunits fashion sharing two atoms curves reveal one step weight loss degrees degrees moreover demonstrate characteristic emission behaviors corresponding ions lifetime decay curves fitted double exponential function addition coordinates obtained based corresponding emission spectra dominant wavelengths color also calculated elsevier rights reserved
study objective research examined impact daylight exposure health office workers perspective subjective sleep quality actigraphy measures light exposure activity sleep wake patterns methods participants included workers working environments comparable workers significantly daylight environment defined one without windows one far away windows without exposure daylight office workers measured short form sleep quality measured pittsburgh sleep quality index addition subset participants workers environments workers windows actigraphy recordings measure light exposure activity sleep wake patterns results workers environments reported poorer scores counterparts two dimensions role limitation due physical problems vitality poorer overall sleep quality global score sleep disturbances component compared group without windows workers windows workplace light exposure trend toward physical activity longer sleep duration measured actigraphy conclusions suggest architectural design office environments place emphasis sufficient daylight exposure workers order promote office workers health
article presents construction test stand created multifunctional stand serves determination main operational characteristics cars transmissions stand consists stand electric motor frequency inverter tested stand used load device simulating road resistance wheels output links half electric motor frequency inverter serves engine driving transmission input shaft measure necessary data pack sensors specific software used stand allows torsional vibrations transmission efficiency loads elements etc results test performed stand driven presented authors published elsevier ltd
performance internal combustion engine directly related fuel quantity react oxygen air oxidation step also called combustion thus amount fuel introduced intrinsically linked air volume admitted cylinder air filling cylinder hence keeping air cylinder one important concepts predict simulations nevertheless phenomenon air filling depends many parameters also discharge coefficients impact piston presence near valves flow valve overlap investigated digital flow bench constructed reproduce series tests carried flow test bench functioning result reduction pressure paper engine studied single cylinder four stroke atmospheric type two valves thus idea paper treat case engines large valve small engines engines variable valve timing first traditional tests single valve performed forward reverse directions systematically tested ensure proper operation digital testing determine differences tests simulations case conventional configurations flow entire cylinder head intake valve cylinder piston exhaust valve system tested studied aim compare results obtained tests simulations valve overlap period significant differences highlighted rates measured one dimensional simulations tests noteworthy one dimensional code overestimated mass passing system valve overlap one fifth estimated mass passing system results obtained test rig
introduction factors associated lower health related quality life hrqol among older african american breast cancer survivors elucidated methods using surveillance epidemiology end results medicare health outcome survey linked dataset identified using recent survey diagnosis individuals physical pcs mental component score points lower median categorized poor hrqol univariate multivariate analyses identified predictors poor hrqol results median age median time diagnosis survey months median follow months median pcs iqr reporting poor pcs median iqr reporting poor predictors poor pcs included advanced age larger tumor size comorbidities inability perform activities daily living modified radical infiltrating carcinoma stage iii disease inability perform independent predictor poor pcs conclusion elderly poor hrqol associated socioeconomic status tumor specific factors rather impairment abstract physical mental hrqol african american breast cancer survivors dependent socioeconomic tumor related characteristics rather inability perform
accepted paradigms mainstream appear incompletely adequate various cases offer analyses however growing number new approaches proposed suggest emergence paradigm shifts area particular quantum theories mind brain consciousness seem offer profound change current approaches unfortunately quantum paradigms least two serious problems first simply models theories assumptions convincing experiments supporting claims second contemporary mainstream views psychiatric illness ways suggest possible way integrate experimental neuroscience quantum models order address outstanding issues psychopathology key role played phenomenon called stream consciousness linked called gamma clearly demonstrated eeg data novel proposal depressed patient seen subject altered stream consciousness particular clues suggest depression linked increased power stream consciousness additionally suggested approach depression extended psychopathology general potential benefits diagnostics therapeutics elsevier ltd rights reserved
paper proposes high performance graphics processing unit gpu based parity computing call gpu redundant array inexpensive reduce encoding decoding time storage applications proposed gpu differs existing performs additional pairwise parallel operations data code words data applying divide approach using extra reserved space also increases parallelism processing multiple strips parallel using multiple gpu threads proposed gpu pipelines data blocks solid state parity blocks hard disk drives target server proposed algorithm decreases span complexity parity computation schedule log number number code words block applied various types codes experimental results show proposed storage application improves average encoding performance average decoding performance compared traditional storage applications respectively copyright john wiley sons ltd
ankle inversion one common sports injuries direct way investigate real injury incidents impossible replicate test participants simulators including tilt platforms devices designed mimic ankle inversion movements laboratories inversion angle element considered early designs however ankle composed inversion clinical observations inversion velocity another parameter increased reality simulation review simulators aimed compare contrast features settings copyright asia pacific knee sports medicine society published elsevier singapore ltd
excessive beta deposition brain associated formation plaques diffuse distribution related alzheimers disease thirty rats irradiated light emitting diode frontal region skull inoculated beta toxin hippocampus rats used control group analysis conducted days irradiation observed decreased beta deposits treated animals compared animals behavioral motor assessment revealed group covered larger ground distance explored open field group days group statistically significant spatial memory test compared group day use significantly reduced presence beta plaques improved spatial memory behavioral motor skills treated animals day
composed two proteins family members detected fluid tissue inflammation release production regulated bacteria cytokines emotional psychological stress risk factor periodontal disease transmitted stress modulators including cortisol aim present study investigate effect stress expression using cortisol cells human cell line incubated presence absence beta alpha adrenergic receptor antagonists cortisol expression mrnas examined northern blotting amount measured enzyme linked immunosorbent assay elisa dna binding activity alpha enhancing binding protein transcription factor examined electrophoretic mobility shift assay stimulated expression mrnas via beta adrenergic receptors cells significantly increased production fold control however cortisol effect expression mrna protein levels elevated alpha dna binding activity cortisol increase activity stress modulator stimulated expression human cells expression regulated stress addition inflammatory factors
urinary tract infections common bacterial infections women increase incidence menopause important uncover underlying abnormalities modifiable risk factors several risk factors recurrent identified including frequency sexual intercourse use abnormal pelvic anatomy postmenopausal women often accompany symptoms signs syndrome menopause antimicrobial prophylaxis demonstrated effective reducing risk recurrent women lead drug resistance causative microorganisms indigenous flora increasing prevalence escherichia coli prevalent resistant antimicrobial agents stimulated interest novel non antibiotic methods prevention evidence shows topical estrogens normalize vaginal flora greatly reduce risk use estrogens reasonable postmenopausal women taking oral estrogens number strategies used prevent recurrent probiotics studied oral vaginal vaccines bladder acid sulfate newer strategies proposed improve urinary symptoms quality life review provides overview prophylaxis without antibiotics focusing practical clinical approach women elsevier rights reserved
still common cause end stage renal disease accumulation glomerular macrophages proliferation cells deposition extracellular matrix proteins hallmarks pharmacological interventions inhibit beneficial retardation progression originally isolated shows anti inflammatory activities variety inflammation models study first investigated vivo effects rat anti anti induced wistar rats mouse anti rat antibodies rats randomly assigned receive twice day vehicle various time points glomerular histology urine protein excretion studied western blotting conducted markers proliferation adhesion molecules chemokine extracellular matrix gene expression evaluated northern blotting treated rats excreted less urinary protein lower glomerular sclerosis increased proliferating cell nuclear antigen akt phosphorylation rats abolished treatment also alleviated glomerular monocyte protein intracellular adhesion molecule similar type alpha collagen mrna levels rats results indicate therapeutic potential proliferative
paper presents formal method designing cryptographic processor basis arithmetic circuits fields proposed method describes arithmetic circuits form hierarchical graph structures nodes represent sub circuits whose functions defined arithmetic formulae edges represent data dependency nodes paper first introduce application graph representation arithmetic circuits extension fields composite fields commonly used design cryptographic processors newly proposed graph representation formally verified symbolic computation techniques based polynomial reduction basis demonstrate capabilities proposed approach experimental design bit aes advanced encryption standard including inversion circuits composite field results show proposed method describe practical complete verification carried within short period time
disease prevention health care delivery areas traditionally governed nation state local communities increasingly mobile carry global prevention strategies treatments grounded universal standards scientific evidence drawing ethnographic evidence research conducted hiv southwest china paper examines impact evidence based science effectiveness global health programming intentions global health partnerships balance power money science technical expertise seeking assistance resources influences global health programming ultimately paper demonstrates demand system universal standards developed basis scientific evidence appreciation local context shapes way standards modified effective implementation global health programs
although bcr hallmark genetic abnormality chronic myeloid leukemia cml secondary molecular events responsible evolution disease blast crisis yet taking account significant association viral integration site cml drug resistance necessary roles played cml disease progression regard cross three microarray datasets deduced set genes seems regulated cml observed strong correlation chronic phase disease found regulated progression disease knockdown cml cell line regulated also rendered cells towards erythroid differentiation study shows involvement axis blocking cml
health care demand among ibs patients imposes heavy economic burden identifying high potential improving quality efficiency care previous research identified reliable predictors utilization ibs patients sought identify factors predictive health care utilization among severe ibs patients ibs patients completed testing whose content mapped onto model health care utilization stage models used determine predictors health care use probability frequency separate analyses conducted mental health medical services whether patients used medical care predicted diet insurance status tobacco use education health insurance predicted probability using mental health care frequency medical care associated alcohol use physical health status frequency mental health services associated marital status tobacco use education distress stress control beliefs ibs symptoms ibs patients demand health care involves complex decision making process influenced many factors particularly strong determinants include predisposing characteristics dietary pattern tobacco use enabling factors insurance coverage impede facilitate demand factors impact use depends whether focus decision use care much care used decisions use medical mental health care simply influenced symptom specific factors variety lifestyle dietary pattern education smoking economic insurance coverage factors elsevier ltd rights reserved
objective spontaneous fluid collection uncommon newly described entity unknown etiology observed infants less year age authors report series infants presented hospital sick children focusing natural history condition methods data hospital sick children retrospectively reviewed period january june patient age sex birth history medical history laboratory findings symptoms reviewed location imaging characteristics management outcome also analyzed medline embase literature search performed condition yielding previously reported cases english language results nine cases involving patients presented study period identified patients male female infants age range weeks months cases developed spontaneously period days infants history injuries trauma hair manipulation immediate period preceding development collections six patients underwent remote vacuum assisted instrumented births although none patients developed collections skin immediately birth cases managed outpatient cases inpatient cases basis case size fluid collection months cases collections resolved spontaneously without structural infectious complications conclusions largest series describing date summarizes cases managed large academic center although specific pathophysiology remains unknown cases condition associated remote history instrumented delivery occurs spontaneously without immediate preceding trauma extensive child abuse necessary conservative approach outpatient follow advocated
modified low cost materials promising properties using pollutants influence extraction agents released iron oxides nanoparticles nps modified studied article stability mentioned new smart material evaluated test characterization prepared sample investigated using ray fluorescence spectroscopy ray powder diffraction spectroscopy spectroscopy sem prepared according european technical standard material interacted water extraction agents treated solution solution discontinuous rotation container laboratory temperature hours stability modified evaluated basis released accompanying elements structure elements determined decomposition atomic emission spectrometer coupled plasma
article development swedish informatics curriculum studied described studys design inspired curriculum theory presented suggest using concept transformation discussing curriculum development data collection study comprises activities actors transformation collected data include contemporary articles journals reports government documents documents findings show informatics education sweden evolved primarily focusing programming knowledge related automatic data processing offered exclusively vocational education later early introduced upper secondary school curriculum informatics curriculum programming system development computing relation applied sciences mathematics teachers much experimental work shown competencies upper secondary school teachers time rarely corresponded demands subject content knowledge resources pedagogical skills stereotypical examples therefore developed support teachers subject content implemented theoretical natural science programme system development transformed twofold issue comprising vocational attributes societal aspects computer programming implementation todays informatics education including programming curriculum draw lessons learned history successful outcome study necessity understand common incentives introducing computer programming curriculum requirement teachers pedagogical content knowledge stakeholders role curriculum development process
individual differences social anxiety extraversion shown influence education outcomes however limited investigation relationship individual differences attitudes towards online offline learning study aimed investigate first time social anxiety extraversion influence student attitudes online offline learning specifically relation tertiary level practical activities based social compensation hypothesis predicted students higher levels extraversion lower levels social anxiety report favourable attitudes face face learning activities predicted less socially anxious students favourable attitudes online learning activities undergraduate students female completed personality inventory mini social inventory measures attitudes towards online offline activities two hierarchical multiple regressions conducted first revealed neither extraversion social anxiety contributed significantly preference online practical activities second regression revealed greater greater extraversion greater lower levels social anxiety associated favourable attitudes towards face face practical activities contrast predictions extraversion social anxiety significantly contribute attitudes online learning activities however line predictions greater extraversion lower levels social anxiety associated favourable attitudes towards face face practical activities findings indicate online learning activities limited compensatory effects students experience social discomfort social compensation hypothesis apply within educational framework unexpected ways elsevier ltd rights reserved
current article reports characteristics gathered first large scale prevalence study interpersonal violence children sport netherlands using retrospective web survey design adults answered questions experiences youth sport study looks number perpetrators individual descriptive characteristics sex age role sport organization perpetrators psychological physical sexual violence reported retrospectively victim respondents information clustered provide overview common profiles results show types interpersonal violence sport perpetrators predominantly male peer athletes frequently operate together groups several differences three types interpersonal violence highlighted incidents physical violence tend less severe compared perpetrators acts sexual violence committed significantly severe presented findings new light perpetrators interpersonal violence sport predominant belief male main providing nuanced information utilized improve prevention child protection measures initiatives sport elsevier ltd rights reserved
purpose compare video computer game play patterns young adolescent boys girls including factors correlated playing violent games methods data collected november december children grades two diverse schools south using detailed written self reported survey results participants female male reported playing electronic games previous months children listed frequently played game almost half played least one violent mature rated game regularly boys girls one third boys girls play games nearly every day plays often always parent playing rated games positively correlated male frequent game play playing internet game system computer ones using games manage anger conclusions young adolescent boys many girls routinely play rated games implications identifying atypical potentially patterns electronic game use discussed need greater media literacy among parents society adolescent medicine rights reserved
paper proposes method analog multiplier current feedback operational amplifier used form second order voltage controlled multifunctional filter designed circuit achieved theoretical analysis pspice simulation actual measurement simultaneously realize low pass high pass band pass filter function results show pass band adjusted frequency range input signal used field frequency characteristic analysis harmonic analysis frequency measurement signal detection furthermore shows importance theoretical significance application prospects
propose experimentally demonstrate microwave photonic system iteratively performs principal component analysis partially correlated channel signals system presented able adapt oscillations correlations follow changing principal components system provides advantages bandwidth performance fan scalability far superior electronic counterparts wideband multidimensional techniques relevant ghz cognitive radio systems bring solutions intelligent radio communications information sensing including spectral sensing
pipeline transportation industry expanded significantly convenience speed faces problems research study failure caused water behavior check valve pump working causes noise pipe deformed due vibration therefore research analyzes deformation pipeline due pressure surge measures vibration system check valve works resulting analysis used predict phenomenon cause deformation pipeline principles fluid structure interactions using theory fluid theoretical mechanics materials engineering used solve problems occur thailand research modeling analysis systems uses ansys program results show predicted failures match actual pipelines
inflammatory bowel disease ibd results complex series interactions susceptibility genes environment immune studies provided strong evidence process autophagy affects several aspects mucosal immune responses autophagy cellular stress response plays key roles physiological processes innate adaptive immunity adaptation degradation aberrant proteins organelles antimicrobial defense protein secretion dysfunctional autophagy recognized contributing factor many chronic inflammatory diseases including ibd autophagy plays multiple roles ibd pathogenesis altering processes include intracellular bacterial killing antimicrobial peptide secretion cells cell function proinflammatory cytokine production macrophages antigen presentation dendritic cells endoplasmic reticulum stress response recent studies identified susceptibility genes involved autophagy active research ongoing world aim review systematic appraisal current literature provide better understanding role autophagy pathogenesis ibd understanding mechanisms bring new strategies treatment prevention ibd
prenatal viral infection identified potential risk factor development neurodevelopmental disorders schizophrenia autism additionally dysfunction gamma acid fragile mental retardation protein glutamate receptor signaling systems also demonstrated two disorders current report characterized developmental profiles selected markers systems mice born pregnant mice infected human influenza virus embryonic day sham infected controls using sds page western blotting techniques evaluated presence abnormalities mentioned markers brain development cerebellum selected light emerging evidence plays roles learning memory emotional disrupted autism schizophrenia identified unique patterns gene protein expression birth postnatal day childhood adolescence young adulthood exposed control mouse progeny also identified significant differences protein expression low density lipoprotein receptor acid kda proteins specific postnatal time points offspring exposed mice results provide evidence disrupted glutamatergic signaling exposed mouse offspring explains multiple brain abnormalities observed animal model wiley periodicals inc
background true essential thrombocythemia carry one known driver mutations mpl calr none triple negative cases patients mutational status seems delineate clinical manifestations materials methods report data patients diagnosed strictly according criteria full molecular diagnosis including following patients calr type calr type mpl thrombotic risk assessed means thrombosis score results calr patients lower levels count patients calr patients type particular higher mean platelet counts extreme often groups based stratification calr mutated patients belonged frequently low risk group significant favourable thrombosis free survival rate mutation conclusion findings indicate three different molecular markers significant impact clinical course true giving rise different phenotypes disease
morbidity mortality heart failure preserved left ventricular ejection fraction similar systolic heart failure pathogenesis remains poorly understood demonstrated systolic heart failure microrna mir inhibit apoptosis cardiac fibroblasts leading cardiac hypertrophy myocardial fibrosis role mir remains unknown employing cell culture technique rat cardiac fibroblasts obtained expression mir two cell types different conditions compared found mir expression significantly higher cardiac fibroblasts established rat model harvested tissues cardiac pathological examination northern blotting forth found mir expression significantly higher model rats sham operated rats model rats developed cardiac atrophy cardiac fibrosis injection mir antagonist cardiac atrophy cardiac fibrosis ameliorated vivo vitro inhibition mir expression resulted reduced bcl expression expression mir led elevation bcl expression study suggested mir promoted development regulating expression anti apoptotic gene bcl thereby suppressing apoptosis cardiac fibrosis
industry national economy industry heavy responsibility low carbon economy essentially point view paper proposed concept low carbon status chinas industry energy consumption pointed cause problem facing chinas industry achieve low carbon propose way achieve low carbon new perspective study low carbon economy proposed countermeasures effective way promote healthy growth industry
obvious vortex induced vibration observed section model wind tunnel tests single main cable suspension bridge optimized section configuration found mitigating excessive amplitude vibration much larger one prescribed chinese code order verify maximum amplitude optimized girder full bridge aeroelastic model wind tunnel test carried differences section full aeroelastic model testing results discussed maximum amplitude derived section model tests first interpreted prototype linear approach considering partial correlation vortex induced aerodynamic force along span based semi empirical linear model good consistency section model full bridge model found considering correlation vortex induced force along span
introduction present demographic differences across reflux disease spectrum district general hospital patients methods data prospectively collected years endoscopy patients categorized reflux disease analysis comparison database without closed analysis demographic differences adenocarcinoma total population diagnosed results sex male predominance male female ratios respectively mean age presentation years years years women older men years respectively prevalent male female ratio incident male female ratio among men developed within sex proportion higher among men diagnosis women slightly significantly older years conclusion two views explain findings first women either reflux reduced mucosal sensitivity hence reflux remains silent longer alternatively women develop reflux later protected longer developing complications early evidence emerging female sex hormones indeed protective role reproductive period suggest reflux consequences example protection conferred copyright wolters kluwer health inc rights reserved
paper presents new identification searching method system parameters nonlinear glass handling robot system using improved real coded genetic algorithm known real coded genetic algorithm method optimal near optimal searching technique concepts biological evolutionary theory furthermore select operators important step affect final identified results paper three algorithm operators including self learning genetic algorithm adaptive real coded genetic algorithm terminal condition combined develop new algorithm system identification proposed algorithm compared genetic algorithms merits numerical simulations experimental results demonstrate proposed identification method best one feasible glass handling robot system driven permanent magnet synchronous motor
clinical importance peanut allergies demands standardized allergen extraction protocols determined effectiveness common extraction conditions reagents extraction time temperatures processing extraction repeats crude protein yields despite similar gel profiles resulted significantly higher yields crude protein ether yields affected composition extraction conditions crude protein yield always correlate yields reducing agents acidic thermal processing perturbed allergen quantification probably via exposure additional epitopes allergen detection western resulted greater sensitivity recommend allergen extraction conditions selected based research question investigated elsevier ltd rights reserved
parents children aged asd completed online surveys assessing parenting quality parenting stress child feeding challenges results indicated food selectivity frequently reported type challenging feeding behavior often reported problematic also type challenging feeding behavior associated parenting stress greater parenting stress reported parenting agreement support lower child disruptive behavior feeding challenge associated quality parenting paper points importance addressing feeding challenges addition selectivity disruptive behaviors within context family home environment
first decades century characterized publication numerous french engineering architecture important solution structural mechanics problems particular tests resistance bending difficult path bounded theories mathematical theoretical apparatus experimental tests proper solution problem marked also errors false ideas huge experimental research order find rules related strength materials design based attention focused works navier preceded brief introduction works parent constant reference made study reference made wood whose mechanical characteristics let observation mechanical behavior bending possible
enthesitis related arthritis era category juvenile idiopathic arthritis common category india hla high prevalence era classification includes exclusion criteria categories due cost routinely done undertook study assess prevalence hla era groups juvenile arthritis india consecutive patients era select patients categories recruited single tertiary care hospital span years hla tested using pcr five hundred eleven children studied era categories systemic onset psoriatic arthritis undifferentiated prevalence hla highest era group correlated presence prevalence rheumatoid factor positive arthritis negative arthritis psoriatic arthritis systemic onset category twenty seven children change category per owing hla testing positive commonly negative group six clinical features suggestive high prevalence hla era though hla testing helps correct classification minority patients features suggestive like back pain enthesitis
cells associated developing ankylosing spondylitis asthma cells also associated allergic rhinitis atopic dermatitis prevalence allergic diseases patients unknown study intended study risk allergic diseases year follow population newly diagnosed patients used nationwide year population based database retrieved longitudinal health insurance database taiwan study cohort comprised patients least claim inpatient admission least claims ambulatory visit comparison cohort consisted randomly selected subjects matched group ratio used cox proportional hazards regression determine year disease free survival rates adjusting potentially confounding factors patients times greater risk developing asthma within years diagnosis compared non age sex matched subjects adjusting risk factors confidence interval difference significantly different patients also times times greater risk developing allergic rhinitis significantly patients also lower allergic disease free survival rate compared non group results showed patients higher risk developing allergic diseases later life
transition metal oxide thin films prepared thermal evaporation low deposition rate material characterization shows thin films composition ions fully surface thin films became thickness increased results show deposition thin film follows island growth voltage extracted values respectively also found large amounts negative charges accumulated interface electron transfer elsevier rights reserved
objective study estimation burden serious fungal diseases france essential data inform public health priorities importance resources research needed infections france precise data available invasive fungal diseases estimates several diseases chronic diseases contrast less known materials methods systematic literature search conducted using web science platform published epidemiology papers reporting fungal infection rates france identified data existed used specific populations risk fungal infection frequencies populations estimate national incidence prevalence depending condition results model predicts high severe asthma fungal sensitization episodes cases adults per year allergic chronic pulmonary besides estimated incidence invasive annually based classical high risk factors estimates invasive respectively regarding invasive cases per year estimated much higher number recurrent vaginal probable confirmed finally survey opportunity report first picture frequency france conclusion using local literature data incidence prevalence fungal infections approximately people france estimated suffer serious fungal infections year elsevier masson sas rights reserved
accumulated data shown human somatic cells tissues show irreversible telomere shortening age strong associations telomere attrition aging related diseases including cancers diabetes cognitive disorders although largely accepted telomere attrition one major causes aging related disorders critical aspects telomere biology remain unresolved especially lack standardized methodology quantification telomere length another issue potentially promising methods safe prevention telomere erosion telomere elongation devised review several methods quantification telomere length currently utilized worldwide considering advantages drawbacks also summarize results recent studies human cells tissues mainly using quantitative fluorescence hybridization southern blotting including derived patients prone syndrome several strains induced pluripotent stem cells discuss possible merits using telomere indicator new marker diagnosis states aging related disorders addition describe newly found factors thought impact telomere dynamics providing new avenue examining issues related telomere restoration maintenance int
background use disorders associated commonly comorbid physical illness fewer data dental disease conditions spite high rates dry mouth associated indirect life style effects poverty lack access care compared oral health people substance use disorders non using controls systematic search studies last oral health people reporting used medline psycinfo google scholar embase article results compared general population oral health assessed terms dental periodontal disease using following standardized measures mean number missing filled teeth surfaces probing pocket depth non tooth loss assessed clinically identified studies sufficient data meta analysis comprising patients controls people sud significantly higher mean scores mean difference confidence interval mean difference teeth fewer indicating reduced access dental care patients sud also exhibited greater tooth loss non tooth loss destructive periodontal disease compared controls substance use disorders greater severe dental periodontal disease general population less likely received dental care
multiple scan statistic usually used test uniformity clustering data article extend work give general expression moments multiple scan statistic circle use moments approximate distribution using markov chain compound poisson approximations proposed numerical results presented evaluate performance approximations
since singapore set implementing mitigation energy efficiency measures key sectors achieve reductions greenhouse gas emissions business usual levels carbon dioxide emissions fossil fuel fired power plants major focus emissions expected reduction electricity generation sector paper explore various strategies electricity generation sector fulfil target use optimization model assess impact strategies emissions electricity generation sector comparison scenario target emissions reduction trajectory three emissions reduction alternative policy scenarios denoted iii carried simulation results indicate three scenarios achieve carbon emissions reduction target electricity generation sector results furthermore suggest electricity generation associated emissions reduction target met measures already available vulnerabilities identified electricity generation fuel mix emission reduction strategies beyond outlined elsevier ltd rights reserved
computational fluid dynamic cfd calculations complex domains porous media require high geometric accurately capturing tested physical phenomena moreover considering large area analysing local effects necessary deploy multi scale approach memory intensive time consuming hence type analysis conducted high performance parallel computing infrastructure paper coupling two different scales based navier stokes equations law described followed generation complex geometries numerical treatment subsequently necessary techniques rather specific tool capable retrieving data servers computation runtime situ described advantages possible drawbacks approach together preliminary results sensitivity analyses discussed detail elsevier ltd rights reserved
todays world high power computing applications image processing digital signal processing graphics robotics require enormous computing power applications use matrix operations especially matrix multiplication multiplication operations require lot computational time also complex design use field programmable gate arrays low cost hardware along low cost general purpose processor instead high cost application specific processor applications work employ efficient algorithm matrix multiplication highly efficient run time reconfigurable floating point multiplier matrix element multiplication run time reconfigurable floating point multiplier implemented custom floating point format variable precision applications efficient combination algorithm algorithm used implement binary multiplier design effectively adjust power delay requirements according different accuracy requirements run time
objective reports concerning treatment combinations mood antidepressant drugs based west surveyed characteristics sites caring mentally asian countries methods cross sectional study used data research study asian psychotropic prescription patterns antidepressants evaluate rates doses given ads associated factors psychiatric patients using standard bivariate methods followed multivariable logistic regression modeling results use increased much associated diagnosis bipolar disorder major depression anxiety disorder hospitalization outpatient care psychiatric general medical programs young age country sex dose conclusions findings provide broad picture contemporary use ads asia support predictions treatment increased recent years associated diagnosis bipolar disorder treatment inpatient psychiatric settings younger age
pixel level image fusion applied variety applications including multi modal medical imaging remote sensing industrial inspection video surveillance night vision etc various algorithms proposed numerous applications requires comprehensive method assessment methods provide decision support currently validation assessment newly proposed algorithms done either objectively subjective assessment costly affected number factors difficult control hand objective assessment carried fusion performance metric defined evaluate effectiveness efficiency fusion operation number fusion metrics proposed fusion processes taking different perspectives image fusion research presents comparison proposed existing fusion algorithms selected fusion metric multiple image data sets proposed algorithm advantage justified relative difference best better metric values however statistical significance difference unknown leading quantitative differences methods paper proposes use non parametric statistical analysis comparisons fusion algorithms along image fusion toolbox employing significance testing strategies use different tests varied scenarios presented recommended experiments recently published algorithms demonstrate necessity adopt statistical comparison establish baseline image fusion research elsevier rights reserved
seasonal affective disorder sad subtype major depressive bipolar disorders associated shortened photoperiod winter depressive disorder tied seasonal regulation brains serotonergic system recently found mice subjected forced swim test exhibited immobility photoperiod dependent depression associated behavior suppression brain serotonin levels however mice nocturnal animals unclear whether brain serotonergic system responds similarly photoperiod nocturnal diurnal species study compared responses brain serotonergic dopaminergic systems photoperiod diurnal nocturnal mice species serotonin levels dorsal nuclei higher long day conditions short day conditions suggesting similarity photoperiod responses serotonergic systems however photoperiod affected dopamine levels various brain regions differently two species brain regions exhibited stronger photoperiod induced changes dopamine levels mice direction changes hypothalamus opposite conclusion photoperiod regulate brain serotonergic system similar mechanisms regardless whether animals diurnal nocturnal photoperiod dependent regulation brain dopamine species specific elsevier ireland ltd rights reserved
devices potential advantages fast read write high endurance together back end line compatibility offers possibility constructing stand alone embedded used conventional circuits systems also power free high performance cmos logic employing logic memory architecture advantages employing devices especially magnetic tunnel junction devices cmos circuits discussed current status based computing paradigm presented along prospects remaining challenges
graphics processing units gpus used accelerating graphic calculations developing general devices one used parallel platforms compute unified device architecture cuda allows implementing parallel multiple gpus obtaining high computational performance last years cuda used implementation several parallel distributed systems end introduced type neural networks inspired behavior networks named random neural networks method successfully used machine learning community solving many learning benchmark problems paper implement cuda gradient descent algorithm optimizing model evaluate performance algorithm two real benchmark problems energy sources addition present comparison parallel implement cuda traditional implementation programming language
objective nowadays psoriasis accepted autoimmune disease result chronic inflammation psoriasis widely investigated associated diseases comorbidities however limited data effects psoriasis hearing functions aim study investigate prospectively patients psoriasis hearing loss effect disease severity hearing levels methods overall patients psoriasis healthy controls included study examination pure tone air bone conduction including high frequencies speech performed participants results median pure tone average patients significantly different controls moreover frequency levels patients psoriasis significantly different control group limitation study patients investigated psoriatic arthritis sera patients also investigated anti bodies inner ear antigens anti anti anti conclusion possibility inner ear involvement kept mind psoriasis result chronic systemic inflammation patients psoriasis evaluated periodically even exhibit hearing problems
african americans use cocaine southern region relatively high risk hiv need hiv testing among group residing rural areas less favorable opinions common hiv testing sites inhibit hiv testing examined rural urban variations acceptability multiple hiv testing sites private physician clinic local health department community health center community hiv fair hospital emergency department blood plasma donation center drug abuse treatment facility mobile van community outreach worker results partial proportional odds logistic regression analyses indicate rural use cocaine lower odds viewing local health departments physician offices drug use treatment centers acceptable relative urban counterparts findings implications targeting hiv testing toward use cocaine particularly residing rural south
traffic related air pollution trap associated lower cognition reduced white matter volume older adults specifically particulate matter diameter rodents exposed trap shown microglial activation neuronal atrophy investigated age differences trap exposure focus hippocampus atrophy white matter degeneration microglial activation young middle aged mice months female exposed diameter young mice showed selective changes hippocampal region atrophy decreased increased gyrus relatively unaffected exposure young mice decreased protein increased mrna older controls age changes effects young response suggesting age effect selective vulnerability young mice vulnerability alzheimers disease propose trap associated human cognitive white matter changes involve hippocampal responses begin younger ages elsevier inc rights reserved
eczema immunocompromised cancer patients identified treated early life threatening commonly found patients skin integrity disorders atopic dermatitis immunocompromised patients simplex type infection trunk head neck regions commonly involved early antiviral therapy crucial immunocompromised hosts prevent rapid progression infections present case adult generalized eczema review differential diagnosis management options
four decades studying human memory research concerns nature memory information suggested individual event integrated memory event actually occurred discussed later occurred become allowing distortion elaboration even total fabrication classes public tried convey one important take home message just someone something great detail much confidence emotion mean true describe professional life experimental process many personal experiences influenced thinking choices
introduction proposed concept training internet things technology within framework radio engineering given practice organization sequencing courses students allows teach design entire system using internet things main part internet things technologies require wide range knowledge skills building unified data collection processing forming control signals feedback circuit single step study practical application allows learn build system programming languages iot technology tool collaborate sensors basic perform data processing cloud services work control signals stage construction iot systems used various programming languages preference given support open operating systems conclusions feature course sequence practical value content final result orientation
atopic dermatitis chronic relapsing highly skin condition resulting disruption epithelial barrier associated immune dysregulation skin genetically hosts generally develops early childhood characteristic age dependent distribution commonly associated elevated ige peripheral allergic diseases medications demonstrated poor efficacy controlling associated education patients regarding primary underlying defects provision comprehensive skin care plan essential disease maintenance management
background children reactive attachment disorder serious socio behavioral problems often rely socially abnormal aggressive forms communication little known however influence teachers socio behavioral development children symptoms aims longitudinal study examined influence teacher sensitivity socio behavioral development children symptoms across one school year method sample included children teachers special education schools previous school year teachers rated inhibited symptoms next school year teacher sensitivity observed interactions individual children first trimester teacher rated overt aggression relational aggression prosocial behavior assessed first second third trimester results found effects sensitivity prosocial behavior also effects found children symptoms children inhibited symptoms increases overt relational aggression observed sensitivity low whereas decreases observed sensitivity high conclusions implications results suggest teacher sensitivity associated socio behavioral development children inhibited symptoms socio behavioral development children symptoms paper adds children reactive attachment disorder exhibit socio behavioral problems hinder school adjustment socio behavioral problems appear relatively stable known influence special education teachers development problems across school year study suggests teacher sensitivity associated changes socio behavioral development children inhibited symptoms whereas high sensitivity associated improvements low sensitivity appeared socio behavioral problems children children inhibited symptoms difficulties communicating needs socially adaptive ways easy teachers understand children teachers childs behavior consequently fail respond childs underlying needs reinforce childs socio behavioral problems increase childs reliance aggressive means interactions others study therefore highlights need support teachers interactions children inhibited symptoms order help understand childrens observable behaviors classroom convey underlying socio emotional needs respond needs importantly teacher sensitivity associated socio behavioral development children symptoms consistent previous research study suggests children inhibited symptoms susceptible quality caregiving environment children symptoms extends finding school context elsevier ltd rights reserved
paper presents new family class operational transconductance amplifier ota circuits based single stage topologies non linear current amplifiers proposed variable mirror amplifier architecture mainly characterized generating class current output transistors exhibiting low sensitivity technology temperature deviations avoiding need internal frequency compensation mechanism hence family suited low power switched capacitor circuits specifically optimized switched opamp fast operation multi decade load capacitance specifications analytical expressions valid regions operation presented minimize settling time discrete time circuits also complete ota design example integrated cmos technology supplied detailed simulation experimental results compared resistor free state art class opamp ota literature proposed architecture returns highest measured figure merit value
design high performance differential difference operational amplifier presented proposed circuit useful continuous time analog signal processing circuit developed using folded cascode amplifier floating current source several applications including grounded resistor voltage amplifier grounded inductor oscillator circuit presented simulation results circuit applications given elsevier gmbh rights reserved
long elastic structures tracks pipelines experience owing axial compressive forces developed result thermal effects many cases structures simplified beam elastic foundation paper presents investigation critical elastic structure nonlinear foundation effects method minimization total potential energy beam foundation system develop differential equation equilibrium differential equation critical bifurcation beam analysis shows critical symmetric mode depending length beam length extremely large two modes indistinguishable equations equilibrium beam highly nonlinear elucidate response beam multiple scale perturbation technique used modal analysis numerical solution based technique developed shown equilibrium beam two stages critical localization stage unstable subsequent stage characterized equilibrium configuration stage dependent relative effects parameters comparisons perturbation solutions results numerical formulation show former technique accurate initial stages localization develops subsequent stage effect foundation parameters also investigated paper american society civil engineers
ambient intelligence emerged integrating concept includes ubiquitous computing ubiquitous communication intelligent user interfaces real implementation concepts based use new technology innovative ways development agent oriented software engineering techniques concepts used way providing support ubiquitous computing communication addition intelligent user interfaces require systems provide efficient rich interface user traditional ones paper presents platform called uses ambient intelligence concepts techniques give fully scalable solution particular problem chosen system provides solution using platform dissemination events system makes available user set events interest kind systems requires high degree users however nowadays user search events interest several different services pages platform introduced paper takes profit agent oriented technology provide system composed various agents run different devices communicate provide user personalized selection events moreover system aware surrounding environment installed smart devices provides rich intuitive user interface uses augmented reality techniques give spatial location data events regarding characteristics solution seems suitable problems domain ambient intelligence
rapidly fatal fungal infection affecting mostly uncontrolled multiple cranial nerves affected however palsy facial nerve rarely reported three uncontrolled diabetic patients presented outpatient department features rapidly progressive unilateral facial nerve palsy evaluation proven patients uncontrolled diabetes facial nerve palsy underlying important early diagnosis treatment favorable treatment outcome
examined culturally relevant gender differences attachment dimensions dyadic associations relationship functioning using large sample considering attachment avoidance culturally incongruent turkish culture exist sharp gender role difference marriage anticipated avoidance women anxiety men strong dyadic predictors satisfaction conflict among married couples dyadic analyses revealed attachment dimensions incongruent cultural characteristics gender roles predicted marital conflict satisfaction avoidance anxiety actor partner effects marital satisfaction attachment anxiety linked marital conflict attachment avoidance seems primary risk factor satisfaction attachment anxiety conflict turkish cultural context
tumor ablation thermal chemical radiological sources received substantial attention treatment many localized malignancies primary goal ablation procedures viable malignant cells within designated target volume application energy chemicals methods radiotherapy chemical biological ablation therapy high temperature ablation microwave laser ultrasound electric based ablation developed focal malignancies recent years large volume data emerged effect situ tumor destruction ablation inflammatory immune components resulting systemic anti tumor reactions evident situ tumor ablation involve tumor antigen release cross presentation release make tumor cellular vaccine tumor tissue destruction situ ablation stimulate antigen specific cellular immunity inflammatory milieu dendritic cells dcs attracted microenvironment undergo maturation internalizing cellular debris containing tumor antigens exposed damage associated molecular pattern mature dcs mediate antigen specific cellular immunity via presentation processed antigens cells immunomodulatory properties exhibited situ ablation future collaboration measures review summarized discuss preclinical clinical studies pertinent phenomena stimulation specific anti tumor immunity various ablation modalities immunology related measures used boost response
immunoglobulin therapy key element management patients primary immunodeficiency disease familiar appropriate evaluation candidates immunoglobulin characteristics immunoglobulin products use provide best care patients available immunoglobulin products appear equally efficacious minimizing risk serious adverse events controlling minor side effects important ideal patient care immunoglobulin administered subcutaneously choice immunoglobulin product mode administration site care optimize clinical outcome minimize burden care american academy allergy asthma immunology
carcinoma associated fibroblasts play pivotal role promoting growth invasion metastasis tumor cells however date little known oncogenic mechanisms study aimed identify factors involved tumor development progression directed liver metastases tissue samples collected patients colorectal liver metastases used study histological morphological characterization samples performed using hybridization assays rna expression smooth muscle actin alpha sma measured northern blotting expression activator inhibitor type measured enzyme linked immunosorbent assay elisa result expression alpha sma identified normal liver samples negative alpha sma compared epidermal growth factor tumor necrosis factor tnf incubation expression alpha sma increased significantly following transforming growth factor tgf incubation platelet derived growth factor caused significant suppression alpha sma expression expression significantly lower fibroblasts compared tgf treated fibroblasts levels transcription significantly higher patient samples compared healthy controls taken together findings suggest important migration matrix degradation invasion angiogenesis tumors tgf promote activation transcription
principle equivalence shown extend situations involving radiation reaction example lorentz force law motion isolated charge undergoing radiation reaction case isolated particle small mass equation motion even radiation reaction included local observer understand motion singular field particle actual electromagnetic gravitational fields measures remaining source free fields used computing motion particle local measurements observer knowledge existence radiation effect describe radiation reaction
limited presence women public sphere reflected restricted repertoire roles played female characters television mainly mothers strengthening feminist movement following decades increased diversified women workplace encouraged academic research social construction working women despite relevance female professionals current shows importance romantic relationships sexuality led decreasing number studies subject article summarizes results study working women spanish part larger project construction female identities research uses original methodology combines quantitative techniques qualitative methods socio analyse sample female characters results show coexistence traditional stereotypes working women customer service care giving positions highly skilled female professionals however empowerment women positions responsibility often associated negative character problems family work systematically avoided
field mouse one common mammals korea however limited research focused population structure mouse throughout korea addition taxonomic status species remains unresolved objectives study address understanding population structure taxonomic status collected samples throughout south korean two nearby islands two remote islands used five microsatellite loci estimated genetic diversity measures populations divergence estimates address objectives except populations two remote islands populations nearby islands indicated low values population structure based microsatellite loci supported one opposing three reported previously korean nearby islands however populations island island showed differences populations korean nearby islands information reported population genetics field mouse korea allow resolving taxonomy species
control systems among important subsystems ability undertake indispensable functions safety critical systems since many key components systems follow different performance degradation paths therefore important approach capable correctly estimating performance control systems containing variety degraded components one solution existing estimation approach capability cope uncertainties inadequate system specifications paper presents hybrid model capable improving existing approaches applying laplace transform time varying model control system taking account varying behaviors components different time slices reliability estimated event based monte carlo simulation require knowledge exact reliability function system reliability improved using particle swarm optimization method method searches optimal parameters control strategy compensating loss effectiveness caused degraded components proposed approach validated case study conducted simulated cooling system numerical results shown proposed approach capable improving reliability control systems subject total run time constraints
paper nano modified method combine give fiber reinforced drying used bone tissue engineering fiber reinforce effective method increase strength materials biocompatibility slower degradation rate providing longer time new osteogenic tissue formation structure morphology composites observed scanning electron microscope sem showed interconnected porous structure fourier transform infrared spectrum ftir ray diffraction xrd used study determine chemical component composites crystal structure treated ethanol vapor scaffolds became water resistance ftir xrd analysis showed matrix composites transformed random coil alpha helical beta sheet structure
objective article illustrates early human development demonstrated magnetic resonance microscopy computer graphics human embryo specimens advanced dimensional clinical obstetrics study design fixed human embryo specimens microscopy coupled computer graphics technology used examine embryos ongoing compare findings results advances microscopy allowed detailed visualization embryo specimens computational techniques allowed reconstruction images render structures high resolution produced images demonstrated neural tube week brain anatomy vasculature week morphology structures week conclusion microscopy novel technique enables high resolution imaging embryo specimens hand allows detailed anatomical visualization vivo basis assessment anomalies human development
known neutral cytosolic alpha alpha alpha alpha linked residues stimulated cobalt inhibited analogues enzyme involved degradation derived intermediates degradation newly synthesized immunological relationship demonstrated rat endoplasmic reticulum alpha cytosolic alpha fact antibodies raised soluble alpha recognized membrane form alpha cdna encoding mouse cytosolic alpha obtained gmbh germany comparison mouse genomic sequence cdna sequence revealed presence within cytosolic alpha gene gene spans major transcription initiation site rna cleavage site transcription initiation site mouse cytosolic alpha mapped bases upstream codon using race northern blotting analysis revealed expression major transcript tissues examined cells transfected cdna showed fold increase cytosolic alpha activity enzyme activity stimulated cobalt inhibited furthermore demonstrated expressed enzyme active towards substrate giving final product formation intermediate elsevier rights reserved
association social networks improved mental physical health documented literature mental health services rarely routinely intervene improve individuals social network review social participation intervention models illustrate different approaches practitioners use highlight gaps evidence base suggest future directions research systematic search electronic databases conducted social participation interventions grouped six categories using modified narrative synthesis approach nineteen interventions countries identified six evaluated using randomised controlled trial grouped together individual social skills training group skills training supported community engagement group based community activities employment interventions peer support interventions social network gains appear strongest supported community engagement interventions overall evidence limited small number heterogeneous studies included review quality suggests social participation interventions increase individuals social networks future research needs use experimental designs sufficient samples follow periods longer months enable make firm recommendations mental health policy practice
onset juvenile idiopathic arthritis characterised prevalent lower limb involvement antibodies positivity high risk anterior observed patients frequently present joint investigated whether relationship series consisted children defined international league associations rheumatology criteria complete clinical data least years duration available clinical laboratory data collected disease onset last follow included sex age presence according score disease activity presence treatment outcome resultsa total patients female male mean age followed average years entered study mean age disease onset years positive occurred present cases onset last evaluation frequent females males less frequent children diagnosis overall disease course subjects least year follow full clinical remission rate significantly higher patients without patients frequent healthy subjects less frequent long term outcome better
childhood trauma associated various forms emotion dysregulation including stress reactivity believed one mechanisms underlying link psychological disorders purpose present study line research using intensive longitudinal research design examine among college students women whether reports interpersonal specifically emotional abuse neglect uniquely moderate within person association repeated assessments daily stress negative affect stress reactivity study also examined whether link stress reactivity stronger discrete forms whether effects emotional abuse neglect unique trauma types distinct recent life stress neuroticism results indicated individuals severe histories emotional abuse showed stronger stress reactivity anxiety forms affect control variables introduced neglect also moderated association opposite direction extensive histories neglect exhibited lower anxiety response daily stress results highlight unique complex associations various forms interpersonal stress reactivity published elsevier ltd
study used paper pencil questionnaire investigate whether teachers administrators parents differed preferences accuracy interpreting visual data displays decision making data analysis used nonparametric tests due violations assumptions using parametric tests found significant differences three groups graph preference within two groups found statistically significant differences preference also found statistically significant differences accuracy parents administrators two graphs grouped columns stacked columns implications researchers education stakeholders recommendations research provided
opened vast pool genes putative yet enzymes knowledge enzyme diversity world new families clear classification still needed exemplified hydrolase family proteins herein describe enzyme resident microbial communities fluid enzyme also shows activities short among preferred substrates large also determination crystal structure enzyme combination deletion site directed mutagenesis allowed identification unusual domain composition active site architecture complexes glucose allowed catalytic pocket illustrated molecular basis substrate specificity hydrophobic platform defined residues located highly mobile loop appears able allocate differently linked includes additional terminal domain previously members full length enzyme unsuccessful therefore small angle ray experiments performed investigate molecular flexibility overall putative shape study provided evidence defines new proteins novel domain topology phylogenetic analysis indicates topology associated microbes digestive tracts animals feeding chemically diverse plant polymeric materials
background three successive international classification headache disorders multiple guideline papers headache care described evidence based diagnosis treatment headache disorders remains unknown however extent improved diagnosis management headache aim study also analysed differences three social groups russia methods studied students females males mean age age range workers females males mean age age range blood donors females males mean age age range conducted semi structured validated face face professional interview data prevalence associated factors previously published section interview focused previous diagnosis treatment topic paper results participants headache russia consulted headache students consulted frequently workers blood donors less often patients diagnosis migraine diagnosis tension type headache previously correctly diagnosed used migraine patients migraine patients patients received prophylactic treatment conclusion despite existing guidelines diagnosis treatment remain poor russia according literature slightly better europe america dissemination existing knowledge higher priority future
default mode network identified reliably rest performance tasks episodic retrieval future remains unclear network engaged across seemingly distinct conditions though many hypotheses proposed account effects prior generating hypotheses explaining common involvement degree across conditions within individuals statistically determined test whether truly network equally engaged across rest retrieval future provide test used comparable paradigms self directed thought equal duration across three conditions rest retrieval future within participant design found lower expected pattern similarity functional connectivity across three conditions similarity connectivity accounted total variance partial least squares analyses revealed medial temporal regions preferentially coupled one another episodic retrieval future whereas non medial temporal regions medial prefrontal cortex lateral temporal cortex temporal pole preferentially coupled rest results suggest connectivity flexible previously considered findings line emerging evidence static network engaged commonly across distinct cognitive processes instead dynamic system changing relation ongoing cognitive demands brain wiley periodicals inc
paper presents comparison two different rating systems evaluate buildings sustainability leed usa italy thanks application methods two residential buildings located italy leed green building rating system encourages integrated design approach points scheme credits building design features deemed improve sustainability includes reductions energy use improvements indoor environment quality protection construction site reduction water consumption use sustainable materials procedure environmental quality rating system adopted italy consists group one different performance indicator aim describing building environmental quality including maintenance indoor comfort entire life cycle chosen buildings located central italy energy efficient designed according principles architecture even characterized different features five common areas site water energy materials indoor environmental quality identified order compare two methods normalize score original approach transferred also comparison building environmental assessment tools comparison allows prove main features schemes even though two procedures give different importance various areas analysis show respective normalized final score two examined buildings elsevier ltd rights reserved
soil varies location location result complex combinations soil forming factors processes operating different scales intensities scale dependent variability soil properties causes challenges characterization mapping soils advent technologies proximal sensors gamma characterize soil spatial variability digital mapping soil properties study aim characterize scale dependent variability proximal gamma complex relationship soil properties different scales using wavelet transform wavelet measured gamma radio metrics gamma ray potassium total count gamma using hand held device field every along point measured elevation land use collected soil samples determine key soil properties electrical conductivity soil organic carbon soc cation exchange capacity potassium wavelet spectra identified significant variations different scales locations gamma ray soil properties significant localized variations changes elevation land use also important cases global pearson correlation gamma ray soil properties significant contrast wavelet provided powerful scale location specific relationship gamma ray elevation land use selected soil properties example strong correlation area significant detected land use soil scales significant positive correlations gamma soc area medium scales similar significant positive correlations area along first half findings provide improved understanding spatial variability gamma ray soil relationships approach used shows scope significant potential use wavelet analysis gamma soil property relationships scale specific useful digital soil mapping moreover scale specific spatial information soil properties aids understanding soil formation processes illustrates approach improve future soil sampling strategies elsevier rights reserved
variety biomedical applications nanoparticles used drug carriers anti tumor agents biosensors modulators immune response full scale real clinical application nanomaterials requires great deal information safety even traditionally materials like gold obtain toxic features scaled vitro studies showed nanoparticles cytotoxic effects body whole remain largely light study focused reproductive toxicity nanomaterials synthesized gold nanoparticles reduction sodium iii alkaline medium addition sodium stabilizing agent next particles administered young old rats days test functional capabilities testes injected antagonist peptide substances known stimulate inhibit central component hypothalamic pituitary gonadal axis respectively routine histological procedures measured diameter nuclear cross sectional area cells markers testicular activity cross sectional area cells nuclei marker testicular found injections caused significant changes young animals time morphometric parameters adult animals significantly lower compared control although observed pathological changes tissue combined administration gold nanoparticles showed effect latter observed specific feature called endocrine moreover found morphological signs testicular degeneration characteristic low testosterone state simultaneous injections gold peptide resulted highest degree testicular functional downregulation regardless age taken whole data indicates gold nanoparticles disrupt regulatory network hypothalamic pituitary gonadal axis possibly due direct action interstitial cells epithelium
dispersion corrected density functional theory dft used investigate mechanism pulp waste removal methyl orange dye aqueous solutions results reliable sufficiently accurate method although big systems studied demonstrated hydrogen bond van der interactions play significant role adsorption adsorption hydrogen bond van der interactions weakened state contrast hydrogen bond van der interactions enhanced state thermodynamic parameters enthalpy free energy change reveal adsorption spontaneous adsorption less favorable state adsorption favorable state therefore controlled adsorption applied adsorption
internet things iot latest internet evolution incorporates diverse range things sensors actuators services deployed different organizations individuals support variety applications information captured iot present unprecedented opportunity solve large scale problems application domains deliver services example applications include precision agriculture environment monitoring smart health smart manufacturing smart cities like internet based services past iot based services also developed deployed without security consideration nature iot devices services vulnerable cyber threats given protection received enterprise services within enterprise iot services play important role daily life resulting improved productivity quality life trend also encouraged cyber exploitation evolution diversification malicious cyber threats hence need coordinated efforts research community address resulting concerns presented special section several potential research topics also identified special section
epidermal proliferation inflammatory changes microvascular augmentation prominent features chronic cutaneous psoriatic lesions objective study investigation blood microvascular changes relation epidermal changes inflammatory infiltration immunohistochemical analysis antibodies vascular endothelial growth vegf morphometric software used quantification following parameters blood vessel area vegf vegf positive area inflammatory cell infiltration epidermal area comparison healthy skin psoriatic lesions showed remarkable elevation measured parameters following average increase times increased times increased vegf vegf area epidermis times times increased times times increased respectively times increased statistical analysis revealed significant positive correlation psoriatic samples blood vessels area vegf expression epidermis showed mild positive correlation epidermal hyperplasia weak positive correlation dermal inflammatory infiltration vegf expression epidermis also significantly correlated blood vessels area found statistically significant positive correlation vessels area cellular infiltration weak correlation epidermal hyperplasia hypothesize angiogenesis psoriasis greater extent responding epidermal hyperplasia lesser way inflammatory infiltration however significantly related dermal inflammatory infiltration
important source material chemical industry rubber pesticides pharmaceuticals general population known ubiquitously exposed thus assessment exposure occupational environmental relevance knowledge human metabolism scarce orally four healthy male volunteers two fast two slow isotope labeled consecutively collected urine samples period days investigated renal excretion metabolites enzymatic hydrolysis sulfate conjugates acetyl predominant urinary metabolite representing oral dose followed acid conjugate acetyl accounting free found minor amounts accounting dose overall four biomarkers excreted urine post dose represented oral dose elimination half times acetyl acid conjugate free respectively urinary maximum concentrations acetyl reached maximum concentrations acid conjugate whereas concentrations free peaked present study one first provide reliable urinary excretion factors metabolites humans oral dosage including data predominant urinary metabolite acetyl also known analgesic name
paper presents application differential evolution algorithm obtain optimal switching angles single phase seven level improve voltage quality proposed inverter article composed two bridge cells non equal voltage sources order generate multiple voltage levels selective harmonic elimination pulse width modulation strategy used improve output voltage waveform generated proposed inverter differential evolution optimization algorithm used solve non linear equations necessary computational results obtained computer simulations presented good agreement theoretical predictions laboratory prototype based microcontroller built order validate simulation results experimental results show effectiveness proposed modulation method
background recent introduction computer aided design computer aided manufacturing cad cam monolithic dental raises issue material low thermal degradation ltd problem hip phenomenon mechanical stress now ltd process studied vitro work introduces original protocol evaluate ltd process monolithic oral environment study general clinical behavior notably terms wear methods design posterior monolithic tooth elements included year prospective clinical trial element several areas determined restoration surface areas submitted non submitted mechanical stress non prosthesis placement vivo analyses regarding ltd wear performed using raman spectroscopy sem imagery laser placement clinically evaluated following criteria world dental federation complemented analysis fracture clinical risk factors two independent perform evaluations clinical evaluation vivo analyses carried months year years discussion clinicians patients results trial justify use monolithic dental practice researchers originality clinical study including vivo analyses material aging provide important data regarding properties authors published elsevier inc open access article license
objective analyze characteristics providers performing stress urinary incontinence pelvic organ procedures united states methods centers medicare services public database released years related related healthcare common procedure coding system providers categorized female pelvic medicine surgery providers non providers using list board certified providers compiled american board medical website physician submitted procedures claims results six hundred twenty nine non providers submitted claims procedures procedures claims following provider specialty distribution obstetrics gynecology remaining performed procedures following specialty distribution remaining performed provider distribution compared mesh insertion procedures mesh removal procedures providers claimed mesh insertion procedures performed mesh removal procedures conclusions medicare reimbursement data provides unique insight distribution provider performing related related procedures medicare population providers submitted majority claims procedures providers also performing majority mesh removal procedures
propose framework understanding multimodal joint work turn construction face face interaction using concepts conversation analysis nonverbal communication gesture studies qualitative analysis face face interaction observe joint work participants produce moves within current speakers turn allow deal possible moves compromise trajectory interaction progress working micro level interaction propose framework allows better understanding turn produced levels sequence organization produced order achieve desired social agreement outcome elsevier rights reserved
introduction severe form central nervous system tuberculosis cns constitutes cases guidelines diagnosis management agree use simple cerebrospinal fluid csf analysis using molecular tools like polymerase chain reaction pcr however sensitivity pcr varies using csf sample present study compared diagnostic utility pcr assay peripheral blood csf sample collected cases aim evaluate application peripheral blood pcr assay alternate tool diagnosis compared conventional csf pcr based system materials methods total patients prospectively recruited patient department central india institute medical sciences january mycobacterium tuberculosis specific pcr liquid culture performed recruited cases classified stage based british medical research council contemporary clinical criteria severity clinical characteristics terms percentages categorical variables age groups gender signs symptoms statistical analysis carried using software version results overall pcr positivity csf around higher culture peripheral blood positive cases stage wise positivity peripheral blood pcr assay three stages stage stage respectively positivity peripheral blood pcr significantly patients csf culture pcr positive infection sensitivity specificity respectively increased positivity rates peripheral blood pcr observed decreased csf blood sugar ratio stage cases suggesting enhanced probability blood dissemination cases severity conclusion results suggest although molecular diagnosis infection csf remains method choice peripheral blood based pcr used good alternative csf case severity repeated csf collection needed however study demands validation large cohorts justify present hypothesis
analyzing basic mechanism dna double strand breaks formation important understanding sexual reproduction genetic diversity location amount examined using common molecular biological technique called southern blotting subset total observed fragments still carrying region recognized southern blot probe detected assumption formation follows poisson process propose two estimators total number chromosome estimator based estimator estimator based record value process compared asymptotic accuracy
incidence writing disorder common reading disorder frequently identified rarely targeted intervention increasing clinical understanding various subtypes writing disorder assessment guided data driven decision making alleviate disparity students writing disorders purpose article provide reader insight clinical reasoning involved assessment intervention planning child writing disorder reader guided authors conceptualization case reflecting recursive problem solving approach assessment intervention
programme formulated since much developed refined web interrelated theory concerning many objects number theory connections fields heart programme concept function famous function riemann zeta function ubiquitous number theory functions applications mathematical physics cryptography two seven clay mathematics million problems riemann hypothesis deal properties many different mathematical objects connected various ways functions study objects highly specialized idea objects outside specialty related helping understand connections motivation functions modular forms database project mission chart landscape functions modular forms systematic comprehensive concrete fashion involves developing theory creating improving algorithms computing classifying hence discovering new properties functions testing fundamental lecture gave brief introduction functions non experts explained demonstrated large collection data organized displayed showing linked objects website also showed created worldwide open source collaboration hope become model others
present paper takes original identification approach named full dynamic compound inverse method recently published journal authors proposes innovative much enhanced version description general forms structural damping including classically adopted damping led extended formulation offers superior performance targeted identification parameters namely modal properties damping coefficients structural features element level input seismic excitation time history synthetic earthquake induced structural response signals adopted input channels approach towards comparison validation identification algorithm run first benchmark shear type frame realistic frame also considering noise added response signals consistency identification results demonstrated definite superiority latter proposal
stress campus problem pre post pilot study assessed impact motivational interviewing via active life coaching via stress management full time english speaking canadian undergraduate students aged years participants assessed using perceived stress scale hospital anxiety depression scale pre mid post intervention three one way repeated measures completed statistically significant differences stress reduction found pre intervention mid intervention pre intervention post intervention statistically significant differences occurred mid post intervention inductive content analysis qualitative interviews pre mid post intervention revealed participants positive experiences
relationship adolescents communication significant others mother father best quality life investigated adolescent pet owners variable attachment also tested assessed mediator relationship positive relationship adolescents communication significant mother father best quality life decreased controlling attachment dogs cat owners positive relationship communication best quality life decreased controlling attachment cat dog owners attachment predicted higher levels quality life higher attachment dogs explained good best attachment best friends mediation effects attachment dogs explained terms caring activities associated types
aim oxytocin presents exciting potential target core symptoms autism spectrum disorder asd easily administered cost effective form possibly minimal adverse effects still major gaps area research paper reviewed randomized controlled trials rcts examining effects oxytocin administration social cognition restricted repetitive behaviors individuals asd method electronic literature searches conducted psycinfo pubmed web knowledge embase rcts published june results rcts included review studies examined social cognition reported improvements additionally one studies restricted repetitive behaviors reported improvements following oxytocin administration however results meta analyses suggest oxytocin significant effect domains conclusion previous evidence revealed mixed findings effects oxytocin asd given limited number rcts summary findings effectiveness oxytocin asd still considered
staphylococcus aureus common cause bovine responsible main economic loss dairy industry identification putative bovine specific molecular marker genome comparison bovine aureus strain previously sequenced aureus isolates associated human infections using genome annotation tool comparison tool act blast databases carried led identification unique gene sequences used molecular marker distinguish bovine human strains distribution genes analyzed collection bovine strains netherlands human clinical isolates pcr southern blotting four genes within pathogenicity island present majority isolates cattle absent human clinical aureus isolates results suggest gene orf uniformly shared bovine aureus strains uniformly used diagnostic marker gene elsevier rights reserved
new taxonomy issues related cad model quality presented distinguishes explicit procedural models type model semantic errors characterized taxonomy validated successfully used classify quality testing tools aimed detecting data errors affect simplification interoperability cad models study shows low semantic level errors simplification reasonably covered explicit representations although many cad quality still small medium enterprises terms cost training time interoperability reasonably solved standards like step model feasible explicit representations procedural representations promising interactive modeling automatically prevent errors derived unsuitable modeling strategies interoperability problems procedural representations expected decrease dramatically step higher semantic aspects quality assurance design intent however hardly supported current cad quality elsevier ltd rights reserved
paper presents new senior health monitoring system using device monitor elderly people detect likely fall measuring gait analyzing change posture change standing vice versa support vector machine used analyze gait posture data obtained device several experiments performed evaluate proposed system experimental results research experience using device presented
clinical copd questionnaire recommended global initiative chronic obstructive lung disease gold evaluate health status patients copd objective work systemically assess reliability validity responsiveness minimum clinically important difference structured search conducted three databases identify articles evaluated psychometric properties individuals copd two investigators screened title abstract full text articles determine study eligibility performed data extraction quality assessment included studies assessed consensus based standards selection health measurement instruments checklist finally studies included half fair methodological quality internal consistency reliability total score ranged test retest reliability overall better correlation respiratory questionnaire copd assessment test cat modified medical research council forced volume predicted scores different within gold stages groups composite events morbidities sensitive exacerbations pulmonary rehabilitation smoking cessation useful practical tool used clinical populations good reliability validity responsiveness interventions
little known quality socially anxious individuals romantic relationships present study examine associations social anxiety social support relationships study collected self report data social anxiety symptoms received provided perceived social support undergraduates romantic partners one year later couples contacted determine whether still relationship results indicated mens social anxiety time predicted higher rates time mens womens perceived support mens provided support also significantly predictive social anxiety interact support variables predict study subset undergraduate couples partner high low social anxiety completed two minute lab based video recorded social support tasks partners rated received provided social support following interaction trained observers also coded support behaviors results showed socially anxious individuals received less support partners interaction according participant observer report high lower social anxiety couples differ terms targets provision support taken together results suggest social anxiety associated difficulties even context established romantic relationships clinical implications discussed
background extensive treated wastewater caused household water contamination finnish town drinking water residents became heavily polluted faecal microbes resulting large epidemic cases reactive arthritis joint symptoms prolonged gastrointestinal symptoms observed outbreak follow survey performed study less familiar long term health consequences within year outbreak methods contaminated group comprised sample residents area polluted water supply control group sample residents nearby presence general symptoms complaints survey prevalence symptom complaint measured twelve analysis results response rate contaminated group control group rash eye irritation weight loss prevalent contaminated group first year quarter last year quarter eye irritation significantly common contaminated group conclusion excess prevalence four complaints first year quarter explained acute intensive water excess prevalence eye irritation fourth year quarter explained sign existing reactive joint disease general long term consequences outbreak considered minor terms surveyed symptoms complaints
order adapt milling machines changing behavior operating due changing tool contact conditions adaptive controllers advantageous approach control machines feed rate otherwise occur leading poor quality paper model predictive control mpc used control feed rate machine applying parameterized model current state milling process future trend predicted order system delay time used model behavior milling machines velocity control loop continually estimating model parameters run time controller current machine behavior developed solutions maximum likelihood estimators models independent parameters state space representation numerically efficiently calculated estimators used estimate parameters order system delay time iteratively based collected process data two validation studies one online estimation based real data five axis machining center one simulation study simulated machine carried validate iterative parameter estimation algorithm studies time variant model whose parameters estimated basis developed estimators compared time invariant model controller adapt changing machine behavior ifac international federation automatic control hosting elsevier ltd rights reserved
paper describes course meet need product life cycle management workforce objective interdisciplinary course introduce students manufacturing engineering theories coupled industry sponsored project throughout building assembly line simulation students exposed topics including process design process verification moreover practices project management along theory critical chain built course end goal prepare students knowledge also capability problem solving communication self motivated teamwork leadership
view limitation construction management system intelligent management platform design proposed microsoft net intelligent client taken front end web service taken middle layer data sql server taken back end database management platform architecture selected testing results show system meets demand engineering construction enterprise project management
nanoscale biosensors owing high sensitivity extremely low limits detection enabled realization highly complex sophisticated miniaturized platforms several important healthcare applications predominant one disease diagnosis particular facilitated electrochemical detection dna hybridization exceptional impact fields genetics cancerous mutation detection report electrochemical platform using semi conducting iii oxide dna hybridization detection proposed platform inherent advantages metal oxide electrochemical transduction techniques resulting label free detection dna hybridization proof concept demonstrate detection consensus primer limit detection control spiked serum samples reported detection limit superior comparison previously reported electrochemical dna hybridization sensors virus detection spanning labeled label free ultra sensitivity believe result synthesizing low metal oxide corresponding specific oxidation state methodology extended detection hybridization interest simply adapting appropriate protocol thus generic nature
background invasive important cause sepsis premature infants associated high risk death neurodevelopmental impairment prevention become major focus low birth weight infants increasingly used prophylaxis methods identified randomized placebo controlled trials evaluating prophylaxis premature infants conducted united states obtained patient level data study investigators performed aggregated analysis occurrence endpoint infants received prophylaxis placebo compared endpoints evaluated death death candida colonization resistance among tested isolates safety endpoints evaluated included clinical laboratory parameters results prophylaxis reduced odds death candida colonization drug exposure period compared infants given placebo odds ratios confidence interval respectively incidence clinical laboratory adverse events similar infants received compared placebo statistically significant difference proportion tested isolates resistant placebo groups conclusions prophylaxis effective safe reducing candida colonization premature infants impact resistance
study conducted evaluate antioxidant properties leaves aqueous extract induced diabetic rats study hyperglycemia induced male rats intraperitoneal injection aqueous extract orally administered dose body weight diabetic rats days effects compared blood sugar body weight lipid profile serum malondialdehyde mda monitored days induction diabetes total phenol contents reducing power also evaluated aqueous extract acid respectively extract found administration aqueous extract produced significant reduction total cholesterol triglyceride low density lipoprotein cholesterol mda respectively diabetic rats effects comparable effects standard drug results investigation indicated leaf aqueous extract possess antioxidant properties diabetic rats therefore study suggest promising use treatment diabetes
paper architecture high speed network security processor protocol implemented system chip soc hardware information encryption key exchange algorithms stored secure digital card terms bit files contrary recent ones actually implemented hardware soc works system running application soc security algorithms implemented also provides communication interface finds applications commerce virtual private network fields require data confidentiality motivation present work dynamically execute applications embedded systems strict resource power maintaining throughput appropriate cipher suite chosen following proposed preferential algorithm based efficient system index budget comprising throughput power resource given user bit files chosen security algorithms downloaded card partial region field programmable gate array fpga proposed soc controls data communication application running system interface network proposed design uses partial reconfiguration feature suite fpga platform performances implemented algorithms considerably better terms power throughput resource existing works reported literatures elsevier rights reserved
paper introduces novel backward forward algorithm fundamental harmonics flow calculation distribution network algorithm fundamental harmonic currents branch calculated equivalent current injection method relationship branch currents harmonic currents order radial calculated injection current receiving end toward sending end obtaining branch currents harmonics bus voltage fundamental bus voltage easily obtained sending end receiving end based kirchhoffs voltage law using method decomposition avoided save huge computational time base special hierarchy characteristic radial network branches sorted layers branch power loss voltage drop computed parallel level computational time reduced test results demonstrate flexible accuracy efficiency proposed method
paper noise control engineering using double leaf partition means analytical approach technique widely used due efficiency providing better acoustic insulation wide frequency range compared single leaf structures double leaf partition construction comprising two leaves separated air space cavity dynamically couples two leaves therefore analysis complicated introduces several scientific aspects paper deals common case double leaf double analytical approach used analyze influence different parameters acoustic insulation plate thickness gap width etc several simulations performed different double configurations assess influence variables final acoustic insulation low frequencies better performance achieved air layers higher frequencies thinner air layer preferable use wall panels different mass resulted wall performing better particularly high frequencies published elsevier ltd
work demonstrate development highly sensitive selective surface resonance label free detection rct low direct liver samples rct kind beta adrenergic agonist development high performance sensing methods critical issue vital role human metabolism construct system biosensor surface formed immobilization rct conjugate onto self assembled sensor chip covalent binding detection rct performed based indirect competitive inhibition principle detailed works carried focusing optimizing conditions affect including immobilization buffer buffer concentration antibody concentration activation time regeneration buffer etc preferable way determine optimal antibody concentration performed comparing used reported researches optimal conditions biosensor exhibits linear detection range improved developed sensitive detection rct reported ones elsevier rights reserved
introduction antiplatelet drug widely used patients acute coronary syndromes stroke despite adequate antiplatelet therapy patients develop acute ischemic events partly attributed fact poor inhibition platelet reactivity despite treatment study aimed assess impact clinical demographic variables cytochrome loss function polymorphisms platelet response evaluated using impedance east european population methods study included treated patients acute coronary syndromes ischemic stroke platelet aggregation evaluated impedance loss function polymorphisms detected using polymerase chain reaction restriction fragment length polymorphism technique various clinical demographic data also recorded results data set patients responders therapy distribution polymorphisms follows patients wild type patients patients patients highest level association response status found polymorphisms concomitant aspirin treatment leukocyte platelet count history myocardial infarction arterial hypertension ward patients admitted conclusion prevalence resistance east european population line reported western populations response significantly influenced presence polymorphisms interestingly concomitant use aspirin significant impact platelet response indicating interaction drugs
study examined effects exposure specific message features usage mental health video games applications based linguistic agency disease causality participants mild depression read messages assigning agency depression humans depicting depression external internal accessing video game designed handling depression symptoms assigning internal causality language led greater game usability higher intentions using games game performance time spent playing games higher external causality language overall findings study demonstrate effectiveness specific message prompt features promote video game experience mental health apps elsevier ltd rights reserved
use modern communication information technology health sector rapidly expanding applications commonly referred also increasingly used psychiatric psychotherapeutic health care despite empirical evidence supporting effectiveness applications symptom reduction areas depression anxiety disorders substance dependence whether applications implemented treatment psychotic disorders specific symptoms cognitive impairment hinder proper handling applications concerns promising projects especially developed patients psychotic disorders context article introduce broad spectrum areas application patients psychotic disorders way four examples specific applications smartphone application focus aims increase self management psychotic symptoms another smartphone application seeks improve communication medication induced side effects patient practitioner adverse side effects uses text messaging systems concentrates relapse prevention therapy focuses specific treatment auditory hallucinations first studies imply applications feasible option also psychotic patients patients rate acceptance high research needed investigate efficacy applications treatment psychotic disorders find solutions problems implementation meeting costs medical
specific leaf area defined leaf area per unit dry leaf mass important component assessing functional diversity plays key role ecosystem modeling linking plant carbon water cycles quantifying plant physiological processes however studies variation across relevant spatial temporal scales lacking remote sensing fast efficient approach quantify vegetation parameters insufficient studies estimating remotely sensed data article aims finding efficient hyperspectral indices fast accurate estimation leaf canopy spectral measurements validation results data measured leaf canopy scale experimental datasets simulated using prospect leaf level inform canopy level revealed predicted accurately several indices simple ratio normalized index types bands sensitive selected using indices spectral region leaf level ratio index performed strongly rmse cross validation indices central wavelengths also among top performing indices measured simulated leaf level data canopy level soil adjusted ratio vegetation index band setting showed hyperspectral data airborne imagery accurately estimated rmse generally canopy level potential indices accurate retrieval imagery two band indices soil line information discrepancy observed performance band combinations vegetation indices leaf canopy scales explained external factors canopy structure soil background illumination sensor configuration affect signal moving leaf canopy level findings suggest availability suitability wide range existing vegetation indices assessing accurately rapidly remotely sensed data elsevier rights reserved
new anaerobic strain belonging isolated strain produce current densities using citrate acetate carbon source three electrode configuration electricity generation performance also analyzed dual chamber mfc system reaching maximum power density addition acetate citrate carbon sources pyruvate acetate citrate also utilized produce current strain data supports presence type grown electrodes linking spectroscopy situ since strains possess many desirable properties compared anaerobic strains strain represents promising species engineering biological catalysts microbial
bit analog digital converter adc presented operational amplifier amp sharing technique bit redundant stages based switched capacitor circuits inverter based digital gain error calibration used reduce power consumption adc amp requirements simulation results matlab simulink structure level cadence level cmos provided adc achieves consumes supply
recently implemented european higher education configuration based degree master structure university country undergraduate programs consist structured years study vary years study access studies requires completion master course cooperative dynamic learning method focused students learning based training development active learning methodologies carried group students along undergraduate master programs order make feel confidence research tasks apply join program develop thesis every effort made promote knowledge research field renewable materials engineering aim research carried evaluation residues industrial processes like proteins design innovative renewable biodegradable materials food packaging applications work arises need reduce problems generated management residues mainly urban ones since materials used food packaging purposes generally one use results showed importance previous knowledge subjects like chemistry materials science offered first second courses chemical engineering moreover abilities acquired students laboratory results discussion final year project highly valued finally students great value taking account environmental factors order prepare sustainable materials high added value market study subject msc renewable materials engineering research oriented master considered previous step studies
chronic kidney disease unknown etiology reported developing countries like india central america without indian sub district namely located south disease etiology common causes diabetes hypertension assumed environmentally induced due asymptomatic nature occurrence groundwater relying communities study aimed understand environmental risk factors underlying ckd using indian sub district case study biochemical analysis affected non affected individuals blood detailed hydro analyses affected non affected regions groundwater drinking water conducted trace element silica highly dominant affected regions groundwater thus potential analysed via vitro cytotoxicity assays human kidney cell lines affected subjects showed increased levels serum urea creatinine uric acid normal blood glucose distinct biomarkers environmentally induced ckd affected subjects reported high blood lead levels suggesting direct resulting impaired blood clearance also exhibits indirect disrupting calcium homeostasis causing skeletal disorders prolonged consumption nsaids pain indirectly causing renal damage affected regions groundwater acidic resulting borderline lead high silica contamination bio availability determining enhanced acidic deficient composition since complex silica reducing bioavailability silica exhibited renal proximal tubular cytotoxicity long term exposure comparable affected regions groundwater silica levels cell death resulting tubular atrophy interstitial fibrosis irreversible renal damage ckd thus study provides novel insights potential trace highlights direct indirect exhibited lead low levels due bio capacity potential considered etiology problem developing countries relying groundwater elsevier ltd rights reserved
background low birth weight extensively related poor adult health outcomes birth weight seen proxy environmental conditions prenatal development identical twin pairs discordant birth weight provide extraordinary model investigating association birth weight adult life health controlling genetics also postnatal rearing environment performed wide profiling blood samples pairs adult twins discordant birth weight look molecular evidence epigenetic signatures association birth weight results association analysis revealed cpg site genome wide statistical significance either qualitative larger smaller quantitative birth weight even selected samples extremely birth weight discordant twin pairs significant site found except displayed age dependent intra pair differential methylation among three sites intra pair differential methylation increased age decreased age genome wide statistical significance sex dependent effects intra pair differential methylation either whole samples extremely discordant twins conclusions genome wide dna methylation profiling reveal epigenetic signatures birth weight although sites displayed age dependent intra pair differential methylation extremely discordant twin pairs
performance improvement capability related organizations ability utilize fundamental asset knowledge employees together learning past projects good links external knowledge sources firms develop mechanisms encourage conversation individuals teams take place particularly todays post job security economic climate performance improvement individual team level overall performance organization paper reports performance improvement work taking place case study company post lean organization order develop capacity team organizational learning improve performance global
important challenge memory competition appropriate inappropriate information retrieval competition normally reduced thanks controlled inhibitory processes suppress irrelevant memories alzheimers disease compromise suppression ability result strong competition relevant irrelevant memories retrieval present review highlights issue examining studies using directed method method participants typically instructed longer relevant information argued reflect suppression memory studies using directed method suggest participants experience difficulties asked suppress longer relevant information working source destination memory difficulties suppressing irrelevant information observed memory retrieval activating irrelevant memories expense relevant ones
first class agent widely used globally first line treatment higher risk syndrome mds report case patient mds suffered rare adverse event acute lung injury suspected caused successfully treated corticosteroids rare critical adverse event clinicians consider one differential diagnoses cases pneumonia fever unknown etiology arise mds patients treated antimicrobial agents effective microbiological tests produce negative results
recent innovations molecular biology colorectal cancer crc genetics facilitated understanding pathogenesis sporadic hereditary crc syndromes development technology enabled data collection number genetic factors lead understanding molecular mechanisms underlying crc incidence nature crc mixture genetic environmental factors current field interest understand molecular basis shape predisposition developing crc disease progression response chemotherapy article summarize new developing genetic markers assess clinical value inherited sporadic crc
cervical cancer one common types cancer among women worldwide order identify micrornas mirnas mrnas associated carcinogenesis cervical cancer investigate molecular mechanisms cervical cancer mirna microarray mrna microarrays cervical cancer retrieved gene expression datasets analyzed order obtain differentially expressed genes mirnas using tool gene ontology pathway enrichment analysis performed using database annotation visualization integrated discovery protein protein interaction ppi analysis conducted using search tool retrieval interacting genes software visualized using followed hub gene identification biological process pathway enrichment analysis module selected ppi network using molecular complex detection addition applied predict targets differentially expressed mirnas total differentially expressed mirnas identified mainly enriched terms associated cell cycle ppi network cyclin dependent kinase dna alpha kinase maintenance complex component higher degrees connectivity significant module detected ppi network family member exhibited higher degrees module genes module mainly involved cell cycle dna replication pathway addition estrogen receptor predicted potential target mirnas total identified potential targets mir conclusion results indicated microarray dataset analysis provide useful method identification key genes patterns successfully identify determinants carcinogenesis cervical cancer functional studies candidate genes mirnas databases lead increased understanding development cervical cancer
background aim study investigate possible association repeat polymorphism interleukin receptor antagonist gene quantitative ultrasound parameters korean males interaction nutritional factor environmental factor methods several parameters including broadband ultrasound attenuation sound speed measured using ultrasound bone korean males mean age year study group divided non mean age year mean age year depending nutritional status also repeat polymorphism gene performed polymerase chain reaction pcr gel electrophoresis method results significant differences genotype allele distribution polymorphism respectively also significant associations parameters among genotype group study groups respectively statistically significant differences among normal osteopenia osteoporosis groups allele genotype distributions polymorphism respectively conclusions taken together results suggest repeat polymorphism gene one useful genetic markers severity osteoporosis korean males nevertheless study yet preliminary studies using larger sample size needed
dynamic nature river channel entrance commonly seasonal evidenced topography river channel east coast influenced north east south west top surrounding parameters waves climate change advanced numerical modelling technique frequently used leading approach investigate complicated nature river channel entrance represent actual conditions designated area paper presented numerical modelling method integrating reduced complexity model approach along local seasonal conditions represent river channel entrance problem propose management measures model established set numerical equilibrium equations calibrated parameters reflect features regional conditions combination local validated modelling parameters model accurately represented effects terms hydraulics sediment dynamics river channel entrance verified site data satellite imagery addition accuracy model provides confidence implementation improvement measures river channel entrance improvement scheme includes training channel improving flushing capacity thus preventing sedimentation upstream flooding allowing proper navigation river conclusion accurate result numerical model successfully demonstrated scientific role solving dynamic river channel entrance serve numerical modelling approach solving similar river channel entrance problems especially east coast predominant inter annual seasonal variations elsevier ltd rights reserved
three year old girl observed marks back arms legs social services initiated examination local hospital conclusion regarding marks reached girl forensic examination three days concluded marks spots case stresses importance able distinguish spots skin need genuine clinical forensic examination cases child abuse suspected guide distinguishing spots skin presented
recent years front national leadership marine experienced political membership numbers public opinion party made impressive gains argue article gains stem least part strategic party based discourse communication style content analysis press releases facebook page first highlight besides giving front national image marine changed front national two rendered discourse managed immigration second quantitative analysis post find new discourse front national
paper application machine learning techniques development constitutive material models investigated flow stress model strain rates ranging quasi static highly dynamic temperatures ranging room temperature obtained beginning directly experimental stress strain data copper objective fully implicit time integration scheme employed integrate hypo elastic constitutive model implemented finite element code evaluation accuracy performance flow stress models derived symbolic regression assessed comparison impact data results obtained free form constitutive material model compared established strength models model mechanical threshold stress model preliminary results show candidate free form models comparing data regions stress strain space sufficient experimental data pointing potential means rapid prototyping future model development use machine learning capturing data guide advanced model development elsevier rights reserved
article addresses concerns growth global governance bringing decline significance sources political one approach evaluating concerns ask whether respective patterns private public authority differ whether refer similar set normative standards private governance regimes provide useful contexts assess presumed erosion seem almost make case decline regulatory authority non state actors nature lack kind afforded procedures state based regulation addition intrinsically linked notion politics form problem solving rather exercise power given characteristics governance arrangements kind subjected one expect responses relate primarily performance normative criteria fundamental individual rights imperative procedure playing minor role basis qualitative content analysis study tests three ideal type patterns case selected examination recent controversy surrounding hybrid governance regime operates prevent use performance enhancing drugs sport debate offers possibility comparison respective patterns used state non state regulatory authority comparison yields two findings first values used state based components sporting worlds hybrid regulatory regime differ systematically used private elements justification cases founded normative criteria relating fundamental individual rights procedure just performance related considerations second finding grounds first type appear importance vis second
large turned new energetic machine needed order explore unknown regions high energy physics reason project future circular started goal developing circumference proton beams collaboration part european community leadership aims develop conceptual design till one main targets design bending able reach operation magnetic field order accomplish size energy constraints magnetic field reached using one option exploration high stored energy large current densities due conductor performances protection one challenging aspects design paper protection design presented standard protection study accompanied less conservative study includes effects power dissipation inside coils magnet inductance order exclude convenient designs develop performing magnet possible
purpose resistance capacitance inductance anisotropic conductive film connections determine high frequency electrical characteristics presence capacitance inductance joint contributes time delays cross talk noise simultaneous switching noise within circuit purpose paper establish experimental method estimating capacitance inductance typical connection help provide detailed understanding high frequency performance assemblies design methodology approach experiments transient response joint performed using digital capable achieving required resolution equivalent circuit model proposed order quantify capacitance inductance typical connection model fitted experimental data full model consisted two resistors inductor capacitor findings capacitance inductance typical connection estimated measured transient response using kirchhoffs voltage law method estimation transient response discussed effects high frequency electrical characteristics connection research limitations implications decay time deviation calculation experiment resulted skin effect high frequency response adhesive surrounding joint main reason capacitance lost research work done determine accurately dielectric losses anisotropic conductive adhesive joint originality value paper presents new method characterise high frequency properties use engineers evaluating performance materials high frequency applications
present viewpoint showing analog signal processing approaches becoming configurable programmable like digital counterparts retaining huge computational efficiency given power budget compared digital counterparts present recent results programmable configurable analog signal processing describing widespread potential approaches discuss issues configurable systems including size power computational address computational efficiency approaches analog circuits systems research education significantly benefit computational flexibility provided large scale component density devices sufficient synthesize large systems short period time however level reconfigurable programmable complexity requires development platform cad tools demonstrate capabilities large scale widely accepted address need self contained setup developed along integrated software design flow connection power outlet researcher student explore numerous analog circuit possibilities provided large scale elsevier inc rights reserved
chitosan based nanocomposites synthesized using versatile ultrasound assisted situ method involving one quick step synthetic route approach results formation nanoparticles average diameter found saturation magnetization ranges depending concentration incorporation chitosan matrix also confirmed ftir techniques hybrid nanocomposite potential application electrochemical sensors since electrochemical signal stable addition situ strategy proposed work allowed synthesize nanocomposite system short time around min time consuming showing great potential replace conventional methods herein procedure permit diversity applications nanocomposite materials engineering elsevier ltd rights reserved
polymeric carriers play important role holding significant potential development novel immunomodulatory agents easily taken antigen presenting cells allow enhanced antigen stability better immunogenicity effect sustained controlled release antigen target sites better information vital understanding mechanism action interaction vectors dendritic cells antigen release kinetics immunomodulatory effects improved knowledge vivo fate distribution now needed collectively speed rational strategies nanoparticles carriers vaccines protein antigens evolution innovative protein dna exciting growing zone immunology enhance clinical outcomes many infectious non infectious diseases review summarizes recent advances nano polymeric especially biodegradable carriers methods preparation surface modification interaction antigen presenting cells release antigens kinetics mechanism delivery vaccines via non invasive routes
water cooled ceramic researched chinese fusion engineering test reactor thermal hydraulic analysis essential remove high heat flux plasma volumetric heat generated paper detailed three dimensional thermal hydraulic analysis whole module performed computational fluid dynamics cfd method capable solving conjugate heat transfer solid structure fluid main results including temperature field distribution mass flow rate coolant pressure drop calculated simultaneously provides beneficial guidance data structural optimization design arrangement primary secondary circuit total heat source coolant mass flow rate required make coolant water corresponding water reactor condition mpa degrees degrees generating total coolant pressure drop delta mpa results show present structural design make materials effectively cooled temperature range except small modifications sides main components including first wall cooling plates side wall plates manifold dominate total pressure drop respectively additionally mass flow rate channel obtained showing peak relative deviation average channels components separately generally results indicate present design meet requirements thermal hydraulics elsevier rights reserved
article intends describe influences different parenting styles development prosocial behaviors primary school children identify parenting style contributes develop purpose spanish english articles published last ten years selected found parents models children tend parental style use exerts great influence inhibitory development prosocial behaviors within different parenting styles style one help develop kind behaviors
much recent research executive characteristics focuses attributes society tends view negatively self interest self serving bias providing insights impact organizational outcomes attributes positively viewed society present top management teams overlooked specifically though conventional view evidence social psychology suggests positively impacts career success upward mobility suggesting least individuals rise level modest previously expected building insight argue positive reactions following calls corresponds higher levels firm performance
methyltransferase enzyme plays major role neurotransmitter inhibition increase neurotransmitter levels provides means treatment parkinsons disease schizophrenia depression exists two soluble cytoplasmic form expressed liver kidneys membrane bound form found mostly brain report backbone chemical shift assignments complex methionine assignments obtained multidimensional nmr spectroscopy total backbone assigned complex possible residues assigned spectrum prediction solution secondary structure chemical shift analysis using good agreement published ray crystal structures
aim study investigate effects expression mouse liver cytochrome evaluate liver toxicity mice real time polymerase chain reaction pcr western blot analyses used analyze expression major isoforms liver toxicity evaluated measuring serum biochemical parameters performing histopathological analysis real time pcr results showed induced fold fold fold mrna expression inhibited fold mrna expression western blot results confirmed expression proteins mouse liver induced whereas inhibited toxicological studies showed oral gavage increased mouse serum aspartate total liver malondialdehyde levels induced liver edema obvious changes serum liver tissue biochemical parameters found significant pathological changes detected liver tissues administration results provide information toxicity related drug drug interactions elsevier rights reserved
paper new system presented manage operations established connect module calling destination floor technique provide feedback door status current floor situations make robot losing way destination computer vision utilized identify current floor special situation human obstacle robot camera floor number indicator difficult light conditions etc robot fails detect current floor number height measurements used addition pressure sensor microcontroller height measurements system hardware platform configured programmed sense environment detect current floor number ultrasonic sensor used recognize door status two methods applied handle pressure variations smoothing filter used handle small variation pressure sensor output practical analysis performed choose filter parameter balancing required time pressure reading stability adaptive calibration method used calibrate sensor readings robots current floor entering overcome wide range variation daily pressure earlier developed localization method multi floor environment utilized identify robots current floor number outside developed method integrated real laboratory mobile robot transportation system numerous experiments implemented different typical life sciences building find average tolerance pressure different obtaining daily variation pressure sensor finally validating proposed operation management system based mobile robot validation experiments prove efficient performance presented system
experienced autopsy case cause death judged poisoning multiple new substances including forensic although unchanged detected solid tissues neither detected blood urine specimens article obtained eight kinds reference standards metabolites commercial source metabolites urine specimen extracted modified method analyzed liquid chromatography tandem mass spectrometry hydrolysis beta among eight metabolites tested metabolites identified urine specimen hydrolysis beta concentrations two metabolites increased suggesting metabolites conjugated forms metabolites detected followed carbonyl concentrations respectively although one preceding report showing estimations metabolism without reference standards first report dealing exact identification using reference standards quantification authentic urine specimen elsevier ireland ltd rights reserved
deep learning popular feature learning method used variety computer vision applications past years surprisingly technique especially convolutional neural networks structure exploited identify human actions achieving great success algorithms existence directly adopt basic structure works ideal situation stable lighting conditions however performance significantly intra variation relation image appearance occurs within category solve problem propose new method integrating semantically meaningful attributes deep hierarchical structure basically idea add simple yet effective attributes category level attribute information able drive learning procedure experimental results based three popular action recognition databases show embedding auxiliary multiple attributes deep learning framework improves classification accuracy significantly
patterns myeloid growth factor usage neutropenia examined patients years age diffuse large cell non hodgkin lymphoma enrolled receiving initial therapy doxorubicin rituximab myeloid administered patients indications use prevent dose reduction dose delay treat non neutropenia one episodes occurred patients often cycle episodes multivariate analysis risk factors included age years odds ratio anemia hemoglobin confidence intervals myeloid use common older population receiving based therapy especially cycle one risk factors predictive used prospectively identify patients myeloid best utilized
paper develops general regression framework analysis manifold valued response symmetric space association multiple covariates interest age gender euclidean space valued data arise frequently medical imaging surface modelling computer vision among many fields develop intrinsic regression model solely based intrinsic conditional moment assumption avoiding specifying parametric distribution propose various link functions map euclidean space multiple covariates responses develop two stage procedure calculate parameter estimates determine asymptotic distributions construct test statistics test hypotheses unknown parameters systematically investigate geometric invariant property estimates test statistics simulation studies real data analysis used evaluate finite sample properties methods
introduction parallel rapid growth access new technologies increase problematic use especially among children adolescents although research field increasing studies mainly developed community characteristics associated problematic use unknown samples require clinical care therefore aim study analyze relationship problematic use video games internet personality traits behavior problems clinical sample children adolescents methodology sample consists patients examined clinical psychology consultation mental health unit children adolescents university hospital data obtained self reports rating scales filled parents results participants present children adolescents lower levels openness experience higher levels emotional instability global impulsivity externalizing behavior problems attention thought problems conclusions problem emerges important issue clinical care children adolescents study child youth care units needed understanding psychopathological profile children adolescents allow development differential specific interventions
article presents rail rail cmos operational amplifier constant offers simple topology low power consumption uses simplified shift level circuit input self biased folded cascode intermediate stage class push pull output stage provide large gain amplifier implemented cmos technology works power supply voltage consumes just offers gain comparison work literature reveal large gain low power rail rail amplifier suitable many applications
problem improving reliability creation fault tolerant systems one important modern technology engineering actually complexity technical systems increasing thus requirements reliability indices constantly increasing especially correct assessment design stage operating conditions important order improve reliability modern trends various types vehicles set similar tasks developers engineers electric propulsion systems considering electric propulsion systems safety critical strict requirements imposed reliability fault tolerance component units traction motor power electronics electric power source control unit paper presents systematic method estimation fault tolerance multi phase permanent magnet synchronous motors based multi level markov model multi state system impact fault tolerance degree regarding number phases permanent magnet synchronous motors investigated practical application proposed technique multi phase traction motor results presented finally results study allowing fault tolerance assessment choice appropriate traction electric motor design considering reliability fault tolerance discussed
work presents three phase harmonics measurement method based modulated sliding discrete fourier transform variable sampling period technique proposal allows measuring harmonic components three phase signal computes corresponding imbalance estimating positive negative zero sequence addition adaptive variable sampling period used order obtain sampling frequency multiple main frequency high rejection distortions electrical network flexibility proposed method makes interesting alternative design grid power monitors
disease caused spp mammals humans worldwide one important borne diseases affects livestock accordingly failing economy systematic review meta analysis study prevalence among domestic iran reviewed nine databases including five english four databases explored total articles regards examination sheep cattle corresponding prevalence different regions iran gathered criteria overall prevalence expected domestic results showed highest prevalence west lowest provinces respectively high prevalence infection mostly sheep confirms established situation iran particularly western northeastern regions country data offered important updated information epidemiology first time domestic iran likely contributing expansion screening control strategies reduce health economic impacts among farm animals
study aimed develop validate instrument assessment patient relevant benefit treatment skin care aged skin based open item collection elderly persons items patient relevant treatment goals collected expert panel selected items relevant feasible questionnaire named patient benefit index aged skin instrument assesses goal importance achievement tested cognitive validated longitudinal study along dry skin area severity index dermatology quality life index convergent validation criteria cognitive showed good feasibility instrument significant correlation change supports convergent validity contrast correlation poor indicating different constructs valid feasible tool patient centered assessment treatment benefit aged skin
age exploration number early developed psychiatric illness either shortly leaving psychotic illnesses stress reactions least six committed suicide either return cases described possible reasons apparent high incidence psychiatric disease suicide discussed also examples possible misuse psychiatric labels
following recent progress super resolution microscopy past decade massive amounts redundant single stochastic trajectories now available statistical analysis flows trajectories molecules proteins sample cell membrane interior high time space resolution several statistical analyses developed extract information contained data biophysical parameters underlying stochastic motion reveal cellular organization trajectories reveal hidden subcellular organization review statistical analysis trajectories based classical equation serves model trajectories parametric nonparametric estimators constructed stochastic equations allow recovery forces diffusion membrane organization measured trajectories differ physical ones localization noise modeling data analysis automatic detection algorithms serve extract novel biophysical features potential wells rings unprecedented spatiotemporal resolution also possible reconstruct surface membrane biological cell statistics projected random trajectories
background mesenchymal stromal cells msc major component tumor microenvironment patients head neck squamous cell carcinoma msc display innate regulatory immunologic functions similar many hematopoietic classical immune cells conversion atp immunosuppressive adenosine immunosuppressive mechanism utilized hematopoietic immune cells present study explores adenosine metabolism tumor derived msc comparison autologous msc non malignant tissue methods patients paired msc generated tumor tissue autologous healthy control tissue differentiation properties phenotype compared flow cytometry production immunosuppressive adenosine functionally active determined mass spectrometry suppressive activity tested proliferation assays isolated cells plasticity explored incubation tumor cell conditioned media results differentiation osteogenic directions comparable expression decreased compared corresponding correlated decreased atp metabolism mass spectrometry proliferation cells significantly suppressed exogenous tumor conditioned medium unable regulate production conclusion identified msc mucosa important exogenous patients reduced expression contribute excessive inflammation tumor growth elsevier gmbh rights reserved
main purpose study investigate application modified chitosan potential vector gene delivery releasing hormone receptor expressing cells design gene carrier useful particular gene therapy cancers related reproductive system gene disorders sexual development contraception fertility control study successfully conjugated chitosan confirmed proton nuclear magnetic resonance spectroscopy nmr attenuated total reflectance fourier transform infrared spectroscopy ftir synthesized conjugated chitosan able dna form positively charged nanoparticles specifically deliver plasmid dna targeted cells two dimensional three dimensional cell cultures systems importantly exhibited higher transfection activity compared conclusion conjugated chitosan promising carrier targeted dna delivery expressing cells elsevier ltd rights reserved
current situation intelligent energy management essential necessary change way delivered also users use small changes life daily turning air conditioning people use result substantial energy savings document provide information support system energy conservation using sensors actuators agents wireless network system embedded interconnected agents sensors monitoring room actuators gradually manipulate elements like windows led air conditioning besides application optimization techniques fuzzy logic energy required give comfort comes two main sources possible artificial company supply electricity natural natural air flows solar lighting etc main goal bio inspired optimization algorithms fuzzy logic control provides adequate lighting temperature settings according activity takes place room
commercial sexual exploitation children associated child abuse neglect poverty societal causes sex trafficking participation commercial sex acts force occur article discusses scope sex trafficking necessary identification skills medical evaluations needed help patients
new current mode high order pole elliptic filters employing second generation third generation current presented paper synthesis method based signal flow graph design simulating passive filters simple architectures obtained along grounded resistors capacitors pole filter design moreover numbers resistors capacitors current proposed pole filters equal numbers filter order proposed elliptic filter designed adding floating capacitor corresponding nodes pole filter counterpart third order current mode elliptic filters demonstrated verify proposed method
nickel alloys containing optimum amounts widely used chemical processing industries due tolerance reducing conditions unlike stainless steel alloys exhibit remarkably high uniform corrosion resistance major concentrated acids like acid acid higher uniform corrosion resistance alloys compared alloys concentrated acids attributed formation protective oxide film reducing acids oxide film solutions localized corrosion resistance alloys containing high amount also significantly higher commercially available alloys present study investigates role elements nickel alloys uniform corrosion resistance concentrated acids localized corrosion performance chloride rich environments using test methodology corrosion tests conducted various alloys results analyzed using weight loss technique electrochemical techniques conjunction surface characterization tools
geosynthetics including geotextiles extensively used soil reinforcement several geotechnical structures foundations walls slopes applications soil geosynthetic interaction plays determinant role paper describes experimental study carried using large scale test apparatus aiming investigate behaviour different geosynthetics embedded residual soil study involved two one one reinforcement high strength geotextile one geotextile soil different relative densities test results revealed soil geosynthetic interaction loading conditions highly influenced geosynthetic properties soil density regardless soil density geogrid exhibited higher resistance geosynthetics maximum force deformation along length geotextiles considerably pronounced along conditions adopted study soil geosynthetic interaction coefficients ranged general values scale effect correction factor obtained geotextiles slightly lower value recommended federal highway administration absence test data
dna vaccine third generation vaccine type based concepts techniques molecular biology closely mimic live infections induce antibody cell mediated immune responses thus much potential treating chronic viral infection cancer transport dna vaccine right target cells lymphoid tissues organs achieve high robust gene transfection efficiency simultaneously inducing maturation antigen presentation questions pose significant challenges addressing require serious efforts developing better biomaterials carriers review dedicated discussion polymers nanoscale carriers dna vaccine summarize recent advances polymer science engineering overcome multilevel dna vaccine delivery conclude thoughts challenges opportunities shape future polymers dna vaccination
paper presents current driver integrated angular acceleration sensor readout circuit architecture proposed amplifier consists voltage follower inverting amplifier achieve differential output amplifier follower based three stage class operational amplifier power output stage output current current driver controlled input voltage maximum value proposed circuit designed cmos technology typical output current flow equivalent sensor load rna rise time
paper presented criterion identification heat transfer regime convection natural forced mixed making use system symbolic computation capabilities criterion based comparison viscous forces analysis realized interior two vertical plates submitted uniform heat flux density steady laminar state fully developed flow thus proposed dimensionless numbers product representative parameter order identify convective thermal regime instead idea based dimensionless number authors published elsevier ltd
land degradation affects large areas land around globe consequences living land major efforts made implement soil water conservation measures counteract soil erosion help secure vital ecosystem services however extent measures implemented often documented knowledge help identify areas soil water conservation measures successfully supporting sustainable land management areas requiring urgent rehabilitation conservation structures study explores potential latest satellite based remote sensing technology use assessing monitoring extent existing soil water conservation structures used set high resolution stereo satellite data derived detailed digital surface model set spectral terrain texture filtered information layers developed applied object based classification approach working two segmentation levels level aim certain landscape zones information landscape zones useful distinguishing different types soil water conservation structures zone contains certain specific types structures level goal extract identify different types linear soil water conservation structures classification rules based mainly spectral shape topographic properties included object relationships approach enabled identify separate classes majority commission errors similar obtained existing studies focusing research objective using different types remotely sensed data based results estimate construction conservation structures study area required person days work huge efforts involved soil water conservation elsevier ltd rights reserved
introduction little known association problem gambling severity psychiatric disorders among american indian native individuals thus examined factors among nationally representative sample american adults usa method using national epidemiologic survey alcohol related conditions data conducted separate tests multinomial logistic regression analyses comparing black african american white caucasian racial ethnic groups respectively results relative american adults adults least likely report non low frequency gambling white caucasian black african american racial ethnic group likely report low risk gambling white caucasian black african american racial ethnic group association risk problem gambling past year axis disorder stronger among versus american adults although associated multiple past year axis lifetime axis psychiatric disorders american adults strongly associated axis disorders particularly major depression generalized anxiety disorder nicotine dependence cluster axis particularly antisocial personality disorder disorders versus american adults discussion stronger association problem gambling severity past year psychiatric disorders among relative american adults suggests importance enhancing mental health problem gambling prevention treatment strategies help individuals elsevier ltd rights reserved
background nutrient mixtures pose great risks physical microbiological chemical contamination preparation storage distribution administration potential hazards controlled high levels excellence prevent serious complications patients result management control medications utmost relevance patient care along ensuring treatment continuity adherence objective aim study develop mobile based platform support control procedures services domain nutrient mixtures efficient manner methods comprehensive approach combining techniques software engineering knowledge engineering used characterization framework local try evaluation performed number application areas carrying test retest monitoring detect possible errors conflicts different contexts control processes throughout entire cycle data absolute relative frequencies percentages calculated results mobile application android operating system developed application allows reading different types tags interacts local server according proposed model also internal mechanism availability system preserved even event problems network connection set test traces generated assessment system various environments tested among traces involved situations properly taken care paper suggesting solutions overcome conclusions mobile oriented system generated tested order allow enhanced control quality management mixtures easy integrate daily health care processes
background aims infliximab adalimumab increasingly used prevent postoperative recurrence crohns disease patients impact previous exposure one anti tumour necrosis factor tnf agents surgery efficacy anti tnf therapy postoperative recurrence unknown methods performed retrospective analysis crohns disease patients underwent surgical bowel resection prophylactic treatment anti tnf therapy january june results total consecutive crohns disease patients bowel resection followed prophylactic treatment anti tnf included patients previous exposure one one anti tnf agents respectively patients surveillance cumulative rates postoperative endoscopic recurrence years patients exposed two anti tnf alpha compared patients exposed one zero anti surgery cumulative rates clinical recurrence year patients exposed two anti compared patients exposed zero one anti tnf alpha surgery multivariable analysis identified smoking previous exposure two anti risk factors crohns disease clinical endoscopic postoperative recurrence hazard ratio confidence interval respectively conclusions previous exposure two anti tnf agents associated higher risk postoperative recurrence crohns disease patients
recent years study shear strength soil geosynthetics attention scholars study changing traditional geogrid structure adding polymeric reinforcement grid grid sought experimentally analyze performance new system increasing coefficient interaction ratio direct shear achieve large scale direct shear tests conducted typical geogrid system results showed average times greater words interaction soil reinforcement system increases almost compared typical geogrid regarding direct shear mechanism elsevier ltd rights reserved
nurses regarding importance health promoting activities healthy eating physical activity stress management sleep hygiene maintaining healthy relationships however knowledge translate nurses self care nurses follow recommended guidelines physical activity proper nutrition long hours work overload shift work associated nursing practice stressful contribute job dissatisfaction burnout health consequences obesity sleep disturbances purpose article provide overview research examining nurses participation health promoting behaviors including intrinsic extrinsic factors influence nurses participation activities article also provides recommendations perioperative nurse leaders regarding strategies incorporate nursing workplace improve health staff nurses increasing health promoting behaviors inc
comparing strings assessing similarity basic operation many application domains machine learning information retrieval natural language processing bioinformatics practitioner choose large variety available similarity measures task emphasizing different aspects string data article present small tool specifically designed measuring similarity strings implements similarity measures including common string distances string kernels distance kernel tool designed efficiency mind allows multi distributed computing enabling analysis large data sets strings supports common data formats thus interface analysis environments matlab
electric motor drive systems ubiquitous developed society falls profession engineering benefit society successful engineering practice systems requires wide range knowledge applied skill university training expected provide engineering teaching laboratories key way providing training development significant paper describes development engineering teaching laboratory intended prepare student engineers industrial practice motivation creation lab pedagogical design describing final technical configuration equipment used successfully teach undergraduate students
paper investigates rise policy community chinas renewable energy sectors decade expansion wind solar energy industries comprises government industrial actors taking shape china main finding research influential leading wind turbine solar panel manufacturers state owned electricity utility companies played important role renewable energy policy process framing strategic preferences policy priority coordinating state actors central local level therefore chinas climate governance domain instead traditional perception state led governance mode state often believed crucial actors climate related policies study reveals governments autonomy policy process increasingly constrained rising industrial interest groups possess considerable resources institutional power chinas renewable energy policy subsystem
introduction use beta one effective methods bone metastasis risk normal tissue toxicity evaluated bone pain treatment methods study monte carlo simulation code used simulation bone phantom model consisted bone marrow bone soft tissue specific absorbed fractions calculated electrons eight beta beta gamma factor absorbed dose cumulative dose mentioned obtained selection optimal radiation characteristics results results show gives higher local dose source organ fewer side effects critical organ including bone marrow comparison cumulative dose versus time shows long time long half life delivering higher dose comparison short half conclusion according results low energy beta used bone pain especially different combination used improving therapeutic effects tumors different size
process commonly used detection biomarkers like proteins viruses multiple sized particles either beads red blood cells create aggregates easily detectable give qualitative information presence biomarkers cases detection made simple eye observation without access kinetics study address development real time time observation using blood typing proof concept developed integrated biological protocol suitable use point care analysis two dedicated image processing algorithms real time quantitative measurement anti anti typing reagents dried inside passive microfluidic chip designed enhance capillary flow blood drop tip established simple biological protocol situ autologous achieved means embedded reagents real time process monitored video recording using training set experiments two real time indicators based correlation variance gray levels optimized confirmed validation set correct discrimination positive negative performed within less min measuring real time evolution correlation variance indicators
web service discovery plays crucial role development applications based service oriented architecture due importance identifying services capable fulfilling requirements service field software engineering web service discovery applied problem software component retrieval order facilitate reuse software components speed development new software projects unfortunately existing service discovery schemes unable perform task effectively due manual service queries lack support service queries using unified modeling language high degree complexity associated integration study proposes novel approach resolving situation referred service component retrieval modeling term expansion proposed system provides three functions generation expanded term set candidate service service repository transformation required models web services description language documents use service queries integration web service retrieval mechanism identification services based textual similarities service integration system designed assist software developers search service components according specific requirements experiment results demonstrate search precision system far exceeds text based approaches
recent years validity embolism quantification methods questioned especially long plants studies suggested cutting tension even water generate artificial accordingly procedure prior hydraulic measurements recommended avoid hand concerns raised occur samples explore potential biases affecting embolism quantification harvested tension relaxation employ direct visualization embolism ray micro computed tomography test occurrence fast low per cent loss conductivity due prior sample harvest excision induced embolism high embolism due air introduction harvest additionally compared response functions regulation embolism pressure short time tension relaxation prior hydraulic measurement resulted lower degree embolism found samples harvested native tensions yielded vulnerability curves similar ones obtained using direct visualization much longer periods hydration required observed occur field grown closure occurred less negative required induce results demonstrate relaxation tension prior hydraulic measurement allows reliable quantification native embolism furthermore find regulation sufficiently conservative avoid induced results suggest evolved strategy resistance rather one tolerance diurnal cycles embolism repair
anti stealth radar difficult problem present nir defense area studying depth using anti stealth technology ground radar reference originally present anti stealth technology live radar borne double feasible pragmatic anti stealth technology radar near future
nurses swedish child school healthcare need balance assignment promoting childrens health development based national health monitoring programme responsibility consider childs needs balancing act encounter children directed strategies fulfil professional aim study analyse extent nurses use different strategies children recurrent health visits throughout childhood quantitative descriptive content analysis used code video recordings displaying nurses encounters children years age constructed observation protocol used identify codes results show nurses use strategies directed strategies encounters children action use within strategy encouraging directed strategy action use primarily use opposing actions understood trying synthesize twofold assignment however seem act able fulfil public function national health monitoring programme rather meet childs needs
dynamic objects motion without stopping platform allows one increase rate operation automatic systems used industrial production processes without compromising accuracy since classical identification based approach dynamic based second order mass spring damper model system yield satisfactory results applied conveyor belt type several extensions technique examined experiments confirm appropriately modified identification based approach becomes reliable tool dynamic mass measurement elsevier ltd rights reserved
urinary tract infections considered among common infectious disorders humans various infections role inducing hae attacks study intended evaluate patients inh hae urine specimens contributed patients inh hae annual control visits studied retrospectively microorganisms analyzed presence relation clinical symptoms taking account three randomly selected urine specimens found cumulative number attacks higher patients without considering patients attack number significantly higher patients without patients found higher incidence edema formation year evaluation suggest triggering role occurrence episodes
past several decades biology developing lens investigated using molecular genetics based approaches various vertebrate model systems efforts involving target gene led major advances understanding lens morphogenesis pathological basis lens related eye defects particular now functional understanding regulators alpha tissue however whether individual regulators interact targets overlap significance interactions lens morphogenesis defined arrival high throughput approaches gene expression profiling microarrays rna sequencing rna seq etc coupled chromatin immunoprecipitation chip rna immunoprecipitation assays along improved computational resources available datasets containing comprehensive protein protein protein dna information presents new opportunities advance understanding lens tissue global systems level systems level knowledge lead derivation underlying lens gene regulatory network defined circuit map regulator target interactions functional lens development applied gene discovery review cover various systems level approaches micro arrays rna seq chip already applied lens studies discuss strategies interpreting vast amounts high throughput information effective dispersion scientific community particular discuss strategies effective interpretation new information context rich knowledge obtained application traditional single gene focused experiments lens finally discuss vision integrating diverse high throughput datasets single web based user friendly tool integrated systems tool eye gene discovery resource already proving effective identification characterization genes linked lens development anticipate application similar approach ocular tissues retina even organ systems significantly impact disease gene discovery elsevier ltd rights reserved
study aimed perform overview ultrasound used implemented applied centers latin america retrospective multicenter year experience study undertaken eighteen centers eight countries involved following information collected demographic data indication perform examination physician required examination anatomical region required examination total patients underwent examination request examinations came frequently institution external referral services frequently requested examination rheumatology followed orthopedic rehabilitation frequently scanned area shoulder cases followed hand knee ankle wrist osteoarthritis common disease assessed patients followed rheumatoid arthritis patients psoriatic arthritis patients painful shoulder syndrome connective tissue disorders systemic sclerosis syndrome systemic lupus erythematosus evaluation frequently requested diagnostic purposes compared follow studies research protocols invasive guided procedures registered increasing applications rheumatology highlighted positive impact daily clinical practice increases accuracy musculoskeletal clinical examination influence diagnosis disease management
parents children autism spectrum disorder asd report concerns child compliance development compliance month old high risk children asd outcomes high risk children without asd low risk children examined high risk asd group showed greater passive months non asd groups smaller increase compliance high risk asd group high risk asd group also showed smaller decline active low risk group controlling receptive language passive findings nonsignificant whereas compliance active findings retained significance growth compliance attenuated children asd changes passive part associated language comprehension
plasma patients types hereditary angioedema unstable incubated plastic vessel degrees manifested progressively increasing formation bradykinin also persistent low level patients even symptomatic phenomena due properties factor complex high molecular weight purified auto activates physiologic activates turn occurs inhibitor deficient complex inducible active site present type release bradykinin phosphate buffer auto activates generate bradykinin thus immunologic depletion inhibitor factor deficient plasma phosphate natural buffer auto activates incubation release bradykinin normal inhibitor prevents occurring attacks angioedema factor auto activates surfaces initial factor formed converts release bradykinin also rapidly activates remaining factor factor additional convert factor factor factor activates levels approach zero depleted also possibility generated first result activation complex heat shock protein released endothelial cells followed activation factor
low power one key driving forces modern large scale integration systems recent studies show integrated circuits ics offer significant power saving ics however studies mainly limited two designs thus paper extend target three ics paper first shows one additional available ics offer power saving compared counterparts careful silicon via management block folding considerations required second find bonded several different ways face back face face face back combined back back face face combined paper shows choices pose additional challenges design optimizations power saving lastly develop effective computer aided design solutions seamlessly integrated commercial tools handle power optimization various bonding style options low power design methods combined ics provide power reduction ics ics cores performance full chip ics provide power reduction ics
total host seeking adult examined prevalence natural focus forest ecosystem along lower reaches river south czech republic pooled specimens per pool inoculated subcutaneously week old specific pathogen free mice dead mice cultivated glucose blood agar impression spleen liver heart blood stained sixty four pools positive overall minimum infection rate mir overall female male examined respectively across years estimated bacterial load infected varied log infectious cells per seven cells low loads prevalent infectious cells detected infected monitoring presence cell numbers valuable tool surveillance
processor new program processing nmr data written java programming language processor cross platform application runs linux mac windows operating systems application run graphical user interface mode command line processing scripts written python programming language executed low level java automatically run parallel computers multiple cores cpus processing scripts generated automatically parameters nmr experiments constructed wide variety processing operations provided including methods processing non uniformly sampled datasets using iterative soft interactive also enables use program educational tool teaching basic advanced techniques nmr data analysis
recent usage control model foundation next generation access control models distinguishing properties decision continuity attribute usage control decision determined combining conditions presented core models park paper attempts identify necessary extensions usage control model express number access control policies relational data management systems based core aspects propose extension core models concerns negative permits specification explicit denial user access object particular mode
many interface events problems occur construction phase construction projects tracking controlling essential construction management interface management become important aspect sound project management strategy affects project cost scheduling quality directly indirectly construction projects interface changed events identified tracked using construction processes improved minimizing reducing total project duration despite many studies discussions academic practical literature systematic approaches information platforms managing interface events problems construction lacking study tracks interface events using novel three dimensional interface maps integrated building information modelling bim approach bim approach utilized retain interface information digital format facilitates easy interface updating transfer cad environment based interface maps provide users overview interface events given construction project users track manage interfaces virtually primary purpose study develop web construction bim based system engineers enhance interface information sharing efficiency tracking construction projects system applied case study building project taiwan verify efficacy demonstrate effectiveness case study results show system effective managing interfaces using bim approach construction
computer based assessments complex problem solving performance often take place group settings like classrooms computer laboratories computer based procedures provide excellent opportunity examine setting effects occur participants tested non group session online time place choosing purpose teacher students randomly assigned one two settings individual online condition computer laboratory group condition strong factorial measurement invariance evidenced participants performed significantly better individual online condition group condition knowledge acquisition knowledge application worse performance group setting compared individual setting neither explained exploration time time task internal experimental design validity conclusion setting related differences cognitive ability testing negligible noteworthy elsevier ltd rights reserved
replacement therapy preferred first option smoking cessation treatment many years reduces desire smoke withdrawal symptoms nicotine addiction rarely develop study present case became nicotine years admitted smoking cessation treated aim case study highlight also effective option treat nicotine addiction rarely seen occurrence
potato encodes mutated adp glucose large subunit introduced rice evaluate potential enhance sink driven yield productivity crop also elucidate activities regulated variants potato large subunit gene rice dna vector containing gene control rice promoter constructed sequence transformed rice using agrobacterium mediated transformation transgenic plants selected medium supplemented confirmed application total transgenic plants subsequently obtained integration rice genome confirmed southern blotting exogenous transgenic rice plants showed high affinity activator low affinity inhibitor observed transgenic rice also showed increases number grains per particle number per plant also fresh weight ground mass plant higher non transgenic number seeds per also found higher transgenic plants however net photosynthesis rate showed little difference transgenic rice therefore confirm linkage effects based results mutant genes used genetic improvement plant potato effectively increase crop yield productivity
leucine associated tumor cell proliferation invasion angiogenesis aimed examine biological function esophageal squamous cell carcinoma expressions examined human tissue cell lines cells recombinant transfected cells expression effects silencing cell proliferation vitro evaluated flow cytometry profiling used detect differentiate cell cycle distribution cells wound healing assay transwell assay used examine activities migration invasion cells overexpressed cells find corresponding results expression level abundance tissue silencing significantly reduced cell proliferation colony formation knockdown resulted cell cycle arrest phase moreover expression cell proliferation also confirms contribution malignant development came conclusion contributed progression overcoming cell cycle arrest proliferative migration effects contribute malignant development human
structural temperature important form loading bridges particularly long span steel structures study temperature distribution bridge united kingdom investigated using numerical simulation field measurements two dimensional fine finite element model typical section box girder long span suspension bridge constructed time dependent thermal boundary conditions determined using field meteorological measurements external surface heat convection coefficients varying according differing local wind speeds experience adopted determine initial thermal condition model transient heat transfer analysis performed time dependent temperature distribution bridge obtained leading numerical temperature data different locations different times good agreement measured counterparts vertical temperature differences box girder also investigated measured numerical results show temperature variation across girder significant effects box girder shape pavement upper bridge orientation finally investigated american society civil engineers
paper discusses mathematics pattern indexing applications recognition visual patterns classification objects represented objects properties matrices shown pattern indexes represented collections inverted patterns solutions pattern classification problems found inverted patterns thus matching original patterns avoided
divided societies promotion cross cultural contact education system central efforts improve intergroup relations approach informed understanding contact hypothesis suggests positive contact member different group contribute improvements attitudes towards group whole substantial body research provides support contact theory argued emphasis encounters result neglect group differences associated issues conflict discrimination contact research discussed article explores tension reference two shared education projects northern ireland research data gathered primarily interviews pupils confirms issues rarely addressed contact explores several influences nature pupils relationships programme structure prevailing social norms avoidance
methodology predicting scaling membrane considers thermodynamics kinetics fluid mechanics developed experimentally validated calcium sulfate theory predicts incidence scaling function temperature concentration flow conditions comparing induction time residence time applying experimental correction factor relevant residence time identified considering volume solution near membrane surface contains enough ions form nucleus critical size theory validated experiments using calcium sulfate model range temperatures degrees saturation indices flow rates although model validated bench scale system compatible large scale systems significant changes concentration temperature flow rate along flow direction lower temperatures saturation index high without scaling safe concentration limit decreases increasing temperature increasing feed flow rate reduces concentration polarization fluid residence time decrease likelihood model translated easily maps safe operating regimes theory maps used choose safe operating conditions wide range conditions system geometries
etiological agent disease one important widespread bacterial pathogens freshwater fish study constructed two artificial markers resistance gene transfer two new artificial markers created placing resistance gene control native regulatory region functional escherichia coli integrative plasmids constructed using markers introduced via conjugation integrated plasmid dna confirmed southern blotting pcr analysis two markers employed future investigations gene deletion pathogenicity virulence factors
majority patients presenting allergic rhinitis asthma several allergens dust chief two important species france studies indicate patients multi however important distinguish allergy exclusively biological phenomenon positive prick tests ige assays term allergy implies existence clinical symptoms detectable precise history taking management dust mite allergies based upon elimination offending source suitable treatment allergy immunotherapy route successful elimination dust depends degree patient extent exposure dust measures taken allergies domestic pollutants present removal difficult dust random case allergens etc form treatment able modify immune status allergic individuals indicated cases poor control rhinitis asthma means global allergen removal systematic treatments multi allergic patients two sources allergens required administered either parallel using two allergen preparations mixture using single preparation given parallel example dust grass recommended interval minutes left two allergens performed using mixture allergens within single preparation recommended preparation made mixture mutually compatible allergen sources prescription multiple importance dilution factor mixing several allergens reduces doses allergen keeping number components used currently reference pathway practically approach utilised children ease use absence pain serious adverse effects performed using high quality standardised allergen extracts particular attention clinical relevance allergens used safety use patients quality life elsevier masson sas rights reserved
virtual desktop infrastructure solutions seek provide satisfactory user experience client side accessing remote desktop applications even mobile devices limited capabilities paper presents new approach improving previous work authors combination virtual network computing streaming protocols allowed efficient remote web access applications within cloud architecture new approach simplifies virtual machine templates virtual machine instances deployed software modules greatly simplifying management new contribution consists integrated solution specific video encoding modules charge application visual output processing transfer protocol http streaming server server solution installed host machines instead replicating servers modules throughout virtual machines run applications consequently implementations unique independent operating system virtual machines short necessary provide different implementations different operating systems reduces complexity virtual machine templates greatly platform management demonstrate solution modified quick kernel based virtual machine source code accordingly also present qualitative quantitative analyses demonstrate new approach advantageous terms software management quality experience compared previous work known thin clients contributing enhancement systems copyright wiley sons ltd
purpose paper explore concept feasibility study economic assessment green building projects benefits preparation financial feasibility study enable client decide considerable confidence whether project feasible worth completion evaluation decision proceed project significant development methodology used direct observation appropriate study therefore research outcome project proposed green building feasible continue lot road malaysia authors published elsevier ltd
paper digital architecture generating piecewise linear arbitrary waveforms presented proposed design able generate piecewise linear periodic signal using minimum number input data generator circuit implements hybrid scheme takes advantage two methods purely piecewise linear interpolation table structure piecewise linear method exploits characteristic reduced memory requirement capability automatically construct waveform repetitive iterative function evaluations table makes use simplicity hardware implementation higher processing speed order verify performance proposal three piecewise linear waveforms successfully implemented microcontroller experimental results show fast execution speed reduced memory demand proposed circuit realization
review article new volume leadership practice research application describes foundation thematic attributes critical uniqueness leadership practice comparing related collective leadership contrasting approaches emphasize leader psychology review highlights contributions chapter emerging movement seeking find leadership people within practices springs
economic feasibility existing canadian houses solar assisted heat pump investigated architecture adopted previous studies conducted canadian climate system utilizes two thermal storage tanks store excess solar energy use later day control strategy defined order use solar energy space domestic hot water heating purposes due economic technical constraints series eligibility criteria introduced house model built introduced eligible houses canadian hybrid residential end use energy emissions model simulations conducted entire year estimate annual energy savings emission reductions results show system performance strongly affected climatic conditions auxiliary energy sources fuel mixture electricity generation energy consumption emission canadian housing stock reduced eligible houses receive system economic analysis indicates incentive measures likely necessary promote system canadian residential market elsevier ltd rights reserved
spontaneously diabetic rat rat model type diabetes mellitus hepatocellular reported model report hepatocellular severe fatty change male week old rat fed high fat diet animal mass approximately diameter right medial lobe histologically mass surrounding tissues slightly adjacent hepatic widely fibrous connective tissues mass consisted tumor cells resembling hepatocytes solid occasionally trabecular growth pattern abundant neutral lipids positive fat oil red ultra structurally moderately dense material contained within tumor cells tumor cells showed increase immunoreactivity number proliferating cell nuclear antigen negative mesenchymal markers findings mass distinguished hepatocellular hyperplasia diagnosed hepatocellular rats hepatocellular accompanied severe fatty change rare first report hepatocellular tumor severe fatty change rat
purpose thinning central etiology unknown result degrading collagen type major protein collagen matrix metalloproteinase mmp able degrade collagen type membrane extracellular matrix ecm mmp enzymatic activity inhibited tissue inhibitor metalloproteinase present study sought investigate evaluate effects single nucleotide polymorphisms mmp risk iranian population sample methods case control study performed patients healthy controls genotyping mmp polymorphisms done using amplification refractory mutation system polymerase chain reaction arms pcr result findings showed polymorphism decreased risk associated allele significantly healthy individuals chromosome increased risk females males allele frequency associated risk protection conclusions study indicates population polymorphism decreased risk however polymorphism associated increased risk
physical training important strategy health people living hiv aids however short term responses yet extensively studied limits understanding effects safety training prescription population therefore aimed systematically review acute responses resulting physical exercise people hiv physiological immunological variables systematic review carried works indexed following databases medline web science science direct keywords used acquired immunodeficiency syndrome hiv aids seropositive acute session short physical activity exercise training searches conducted february updated december conducted without restriction publication dates specific language included review articles evaluated acute responses derived model prescription physical training involving aerobic weight combined exercises aerobic weight exercises related physiological immunological variables hiv infected individuals found exclusion application eligibility criteria seven articles selected qualitative synthesis according results reported studies evidence immediately physical exercise increase number circulating cells occurs including total leukocytes neutrophils monocytes lymphocytes hiv infected people furthermore significant changes concentrations lactate triglycerides also observed immediately aerobic training regardless use however insufficient evidence state physical training totally safe effective population
south population grown considerably last decade food insecurity mental illness common developing countries relationship remains african population adult south africa interviewed using self report food insecurity symptom checklist proportion responded often true enough food eating less respectively proportion individuals significant level anxiety depressive symptomatology respectively adjusted logistic regression indicated eating enough significantly associated anxiety aor depression aor similarly eating less significantly associated anxiety aor depression aor high prevalence food insecurity relationship mental illness highlight importance addressing basic needs among population
describing user activity plays essential role ambient intelligence work review different methods human activity recognition classified data driven knowledge based techniques focus context ontologies whose ultimate goal tracking human behavior studying upper domain ontologies useful human activity representation inference establish evaluation criterion assess suitability different candidate ontologies purpose result missing features relevant modeling daily human behaviors identified future challenges
background children adolescents involving antisocial behaviour one strongest predictors development antisocial personality disorder adults rapid cognitive physical development occurs stage life even though knowing antisocial behaviour highly problematic society due disruption societal norms prevalence behaviour community known aim estimate prevalence antisocial behaviour among children adolescent age groups materials methods total participants sexes children adolescents age years educational institution district parents advised come school get interviewed using child behaviour check list years order assess antisocial behaviour among children adolescent age groups along self constructed questionnaires assess personal bio data factors responsible behaviours considered statistically significant results overall prevalence antisocial behaviour age groups males higher prevalence antisocial behaviour compared female counterparts prevalent antisocial behaviour vehicle related followed criminal damages differences causal factors among genders significant conclusion identifying factors associated antisocial behaviour among children adolescents critical developing effective preventive strategies early intervention minimise risk progression serious criminal behaviour later life study concluded much antisocial behaviour exists among children adolescents school students behaviours found significantly associated respondents gender parents economic status parenting style
paper consider problem synthesis equivalent circuits containing nonlinear electrical circuits general number non linear elements system differential equations describing linear non autonomous multi pole transformations allows synthesize equivalent circuit multi pole consisting two pole linear nonlinear resistors controlled voltage sources etc question replacing series connected voltage sources controlled operational amplifier implementation linear nonlinear two pole resistors
engineering excellent insulation mechanical properties however low thermal conductivity restricted application electronic devices hexagonal promising material high thermal conductivity functionalized cationic polyacrylamide introduced matrix improve thermal conductivity sem xrd analysis showed modified particles oriented formed thermal conductive pathways within matrix formation large area oriented significantly improved thermal conductivity thermal stability composites loading thermal conductivity temperature weight loss degrees obtained times degrees higher pure respectively furthermore outstanding electrical insulation property matrix retained composites results revealed composite promising material thermal management electrical wiley periodicals inc
systems used upgrade anaerobic biogas directly converting objective study evaluate gas carbon transport within four configurations evaluated abiotic anode abiotic cathode abiotic cathode abiotic anode transport gas commonly used flushing systems anode ranged normalized proton exchange membrane surface area net driving pressure transported cathode anode rates flux cathode anode greater system produced abiotic cathode even though abiotic cathode end day day carbon balance batch fed showed transient microbial carbon storage net transport carbon anode cathode day batch incubation production greater molar basis initial supplied indicating conversion produced anode research expands current understanding operation used improving assessment performance development alternative designs mathematical models wiley periodicals inc
devastating parasite western light arm race opposing host parasite population dynamics genetic diversity organisms key parameters however life cycle characterized extreme due full mating host cells present equation reflecting evolution clonal system compare predictions empirical data based analysis seven microsatellite markers comparison revealed perform essentially mating beginning season however pattern changes development mite despite fact overall level genetic diversity remained low season multiple lineages identified sampled june response decrease availability increase parasite population parallel colonies lineages towards end season cells results suggest ratio number mite per cell colony determines genetic structure populations population dynamics great relevance selection resistance chemical treatments occur recombination phase greatly enhance fixation resistance alleles colony level elsevier rights reserved
super saturated salt solutions used control relative humidity infer hydration water uptake loss behaviour three needle geosynthetic clay respect time conditions free kpa applied stress shown applied stress play key role hydration behaviour time specimens equilibrium water also observed water uptake loss affected form granular however effect structure difference geotextiles bonding needle fibres carrier geotextile hydration behaviour similar form significant effect structure became apparent results presented study used better assess hydration field applications waste cover systems different stress conditions
research shown mimicking someone way perceived positively increase compliance helping request effect mimicking children compliance request change food consumption however never examined nine year old children either beginning interaction children asked eat piece fruit least week try eat drink least week results show children consumed fruit longer period time children also asked parents fruit wanted continue eating fruit changes fruit consumption confirmed mother results suggest influence child behavior used promote changes eating behavior elsevier ltd rights reserved
abstract present study examined individual differences susceptibility two similar forms memory distortion misinformation effect bias misinformation effect occurs individuals event provided misinformation recall original event containing elements misinformation bias occurs individuals make judgments provided feedback recall original judgments similar feedback actually seventy five participants completed misinformation task bias task several individual difference measures related memory distortions working memory capacity negatively correlated misinformation effect bias misinformation effect bias negatively correlated one another although misinformation effect bias measured similar designs predicted working memory capacity negative correlation suggests phenomena result somewhat different processes
background aim present study investigate preventive effect leaf extract experimental hypothyroidism materials methods forty male wistar rats randomly divided four groups ten rats group control hypothyroid control extract hypothyroid extract rats group receive intervention throughout experimental period rats groups received pretreatment leaf extract weeks subsequently next weeks rats group received drinking water group received leaf extract group received leaf extract results hypothyroid group rats exhibited dramatic increase thyroid stimulating hormone tsh levels concomitant depletion levels thyroid hormones treatment extract resulted remarkable improvement thyroid profile extract produced fold increase plasma free fold increase free fold decrease tsh levels group comparison group treatment extract ameliorated decreased levels plasma reactive protein tumor necrosis factor alpha suppressed tissue oxidative stress prevented hepatic renal damage caused due thyroid hormone depletion group alpha beta identified quantified extract conclusions first study reveal extract therapeutic potential restore thyroid hormone levels prevent biochemical complications due thyroid hormone insufficiency animal model experimental hypothyroidism
introduction approximately patients received coagulation factor concentrates early infected hepatitis virus hcv approximately infected hiv aim evaluated efficacy safety administering japanese patients methods forty three patients genotype hcv treated weeks efficacy safety results laboratory tests evaluated results twenty patients hiv hcv sustained virological response weeks therapy hiv positive patients hiv negative patients efficacy significantly different hiv positive hiv negative patients however rate weeks therapy patients cirrhosis significantly lower patients without cirrhosis overall patients adverse events severity mild moderate serious including death hiv positive group patients completed treatment alterations antiretroviral regimen significant abnormalities renal function detected patients taking antiretroviral regimen conclusions cohort study effective safe patients cirrhosis lower group thus patients genotype hcv treated early possible onset cirrhosis
background robot assisted manipulation promising solving problems risk infection intestinal endoscopy however commonly used friction existing systems potential risk flexible non uniform methods paper presents robotic system standard flexible focuses novel intervention mechanism provides uniform works relay mechanism way similar manual operation shear stiffness critical force csf analysed determine parameters fuzzy pid controller employed realize fast response high accuracy pneumatic actuation experiments performed evaluate accuracy stiffness csf vitro vivo animal experiments also carried results realized accuracy push pull rotation without delivery resistance delivery resistance error caused stiffness quadratic polynomial used describe relationship csf pneumatic pressure conclusions novel effectively deliver pneumatic driven method proposed protect uniform force csf properly controlled guarantee operating safety copyright john wiley sons ltd
eco toxicological effects bacillus maize life history traits widely studied results controversial effects bacterial community rarely studied effects two hybrids maize event return bacterial community investigated terminal restriction fragment length polymorphism rflp polymerase chain reaction gradient gel electrophoresis pcr dna sequencing compared near non maize maize return significant effects soil nutrients especially available nitrogen significant differences shown soil bacterial community non maize treatments closely correlated soil available rather protein statistically significant difference bacterial community gut contents non maize treatments significant differences bacterial community found among three maize varieties treatments closely correlated protein levels differentiated bacterial species mainly belonged including pseudomonas etc associated mineralization metabolic process degradation plants residues therefore maize return caused changes bacterial community possibly caused direct protein non expected effects levels maize elsevier ltd rights reserved
numerous simple impedance based microcontroller dedicated impedance converter integrated circuits reported recently many applications sophisticated analogue circuitry enhance measurement possibilities circumvent limitations paper impedance based solely general purpose operational instrumentation amplifiers presented uses internal dac generate excitation measure response measured object also uses external analogue circuits condition excitation signal measure voltage current magnitudes phase shifts voltage current evaluated using three parameter sine fitting algorithm allowing fast low frequency impedance measurements calibration procedure completed device presented tests accuracy device allowed measurements frequency range mhz khz omega omega impedance range accuracy also compared precision impedance middle impedance ranges omega omega discrepancies two less elsevier ltd rights reserved
objective unusual clinical course background systemic lupus erythematosus sle autoimmune disorder unknown etiology present age symptoms musculoskeletal renal central nervous system nonspecific clinical pictures making disease master case report year old female recently diagnosed sle presented right sided sharp electric shock like facial pain starting side right traveling fold back angle mostly region distribution radiation beyond trigeminal distribution pain going last years regarded however progressed frequency last weeks clear identifying triggering factors laboratory test results showed positive anti nuclear antibodies raised anti double stranded dna anti anti syndrome related antigen anti syndrome related antigen anti smooth muscle antibodies possibilities migraine palsy brain tumor ruled diagnosis sle trigeminal made times day prescribed conclusions seldom mentioned neurological manifestation sle hence recommend studies investigate sle mediated injury trigeminal fibers make timely diagnosis prevent progressive autoimmune process related demyelinating changes
purpose study explore parents sex related concepts young children study used feminist phenomenological research methods data gathering analysis social development theory positive sexuality framework also used study design participants included parents mothers fathers least one child aged years old researchers performed semi structured individual interviews data analysis included developing themes illustrated essence parent understandings phenomenon two themes emerged data analysis parents never findings illustrated relationship parents perceptions social development theory positive sexuality framework feminist analysis revealed gender differences mothers fathers approached sex related discussions children implications practice policy research included
wealth associated differences peoples self concepts propose self concepts define types effective motivating across three field studies randomly assigned participants view appeal organization emphasized agency pursuit personal goals pursuit shared goals appeal emphasized agency individuals reported greater willingness give money contrast appeal emphasized less individuals reported greater willingness give findings explained relevant demographic characteristics age ethnicity gender work adds growing body research suggesting wealth inherently result tailoring messages fit peoples self concepts possible catalyze giving across socioeconomic spectrum elsevier inc rights reserved
background smoking shown reduce health related quality life hrqol patients coronary artery disease cad undergoing coronary intervention either means use bare metal drug des now widely used related substantial reduction significantly improved hrqol compared study aimed evaluate effects smoking hrqol patients des era methods cohort patients admitted cad treated drug included prospective observational study patients classified non smokers persistent smokers according smoking status time first admitted hospital first year follow patient prospectively interviewed baseline months year following hrqol assessed use medical outcomes study item short form health survey results overall population hrqol scores year follow significantly higher baseline domains year follow hrqol scores persistent smokers still lower non smokers domains except bodily pain mental health domains except bodily pain role emotional mental health significant differences regard scores non smokers except role emotional non smokers higher scores adjustment persistent smokers demonstrated significantly less improvements hrqol non smokers domains except bodily pain social functioning significantly less improvement general health improvements comparable non smokers domains multivariate linear regression analyses showed persistent smoking independent risk factor pcs improvements conclusions persistent smoking substantially potential quality life benefits des efforts made promote smoking cessation des implantation greatly improve health quality outcomes
lung cancer screening low dose computed tomography scan now covered centers medicare medicaid services following evidence based recommendation shared decision making process inform patients risks limitations awareness campaign promoting opportunity elicit patient engagement health providers risks benefits focus groups representing three regions known high lung cancer rates discussed development lung cancer screening campaign recommendations included messaging content design campaign implementation trusted information communication sources community health workers three eastern regions recruited individuals local communities using established client files six total focus groups participants using questions guided communication matrix framework sessions recorded transcribed independent content analysis total individuals female pack year history participated prior discussion participants heard lung cancer screening cited needs content campaign included benefits early detection payment information messages considered include personal messages hope prolonged life emphasis family survive information come ones family doctor specialty provider considered important message communication messages family prolonged life considered lung cancer screening awareness campaigns results provide community input messages regarding screening options
compared different types renewable energies wind energy fastest annual growing rate last decade hence employing framework based numerical algorithms optimal design electrical generator especially adopted wind power systems great challenge electrical systems recently rigid structure high torque density lower mass flux switching permanent magnet generators attracted much interest capable conventional permanent magnet synchronous generators paper new analytical hierarchy process ahp approach proposed multi objective optimization design generator carry optimization trade offs considered among conflicting targets cost mass electromagnetic performance finite element method numerical results experimentally validated means prototype used assess required data optimization optimal solutions given ahp method compared solutions obtained using different classical optimization methods results showed ahp approach gives best solution respect earlier designs also respect conventional optimization methods confirming effectiveness used optimal design electrical machines copyright john wiley sons ltd
special dimer commonly called bacterial early phase exclusive dna photo damage product bacterial generation repair responsible extremely high resistance early vivo studies suggested utilizes direct reversal strategy repair absence light research past decade established radical sam enzyme utilizes tri cysteine motif cluster oxidation state cluster provides electron sam binds cluster manner fourth fifth ligands bond associated ion sam generating reactive radical radical abstracts hydrogen atom carbon initiate repair process resulting radical subsequently fragments generate putative methyl radical back atom yield sam suggested regenerated end catalytic cycle catalytic amount sam needed reaction atom source back donation step suggested cysteine residue bacillus atom transfer reaction leaves radical behind protein radical thus participate sam regeneration process however radical abstracts atom sam unknown paper reviews discusses history latest progress mechanistic elucidation despite recent questions raised mechanistic understanding intriguing dna repair enzyme article part special issue entitled radical sam enzymes radical enzymology elsevier rights reserved
methane carried internal combustion engine engine successfully produced partial oxidation natural gas cylinder diesel engine perform spark ignition performing reaction engine cylinder allows captured useful work intake conditions degrees allowed low cycle cycle variability methane air equivalence ratios phi producing ratio spark ignition timing varied degrees top dead center piston position showing significant improvement delayed timing hydrogen added simulate downstream synthesis reactor realistic natural gas compositions respectively adding gases yielded stable combustion hydrocarbon air equivalence ratios phi equivalence ratios results demonstrate engine key component compact gas liquids synthesis plant highlighting operating conditions high gas conversion high ratios close low production possible
combined hormonal contraceptives contain estrogen progestin stimulate estrogen sensitive progesterone sensitive breast cancer growth recently almost estrogen used decades dose greatly reduced time first generations birth control pills contained approximately five times estrogen four times progestin latest contraceptives newer also contain steroids closely mimic physiological estradiol progesterone effects newer formulations thus expected less influence breast although difficult demonstrate difference among recent available preparations human studies recently acetate neutral progesterone like profile progestin become available combination natural estrogen according literature expected either lesser stimulating effect neutral effect estrogen sensitive breast cancers performed analysis available studies review endocrine metabolic effects formulation lead lesser breast tissue stimulation data reported confirmed clinical studies considered choosing hormonal contraceptive especially breast stimulation concern anti cancer drugs wolters kluwer health vertical bar
background aims food important gastrointestinal motility secretion many patients functional bowel disorders fecal urge stool output eating patients methods prospective observational study consecutive outpatients functional bowel disorders female years filled rome iii questionnaires depression anxiety scores physiological evaluation total colonic transit time colonic transit response eating using standard test meal measured univariate analysis multivariate logistic regression carried according presence stool output eating results eating found patients patients different according demographic characteristics sex ratio age bmi contrast lower state anxiety similar scores depression trait anxiety similar characteristics anal pressure rectal sensitivity greater response eating segments colon increase frequency functional diarrhea odds ratio confidence interval syndrome odds ratio confidence interval functional bowel disorder including irritable bowel syndrome subtypes found conclusion stool output eating associated clinical disorders physiological parameters symptom associated irritable bowel syndrome higher frequency functional diarrhea copyright wolters kluwer health inc rights reserved
many psychology applications assess measurement invariance construct depression time applications often characterized time points high rates dropout although applications routinely assume dropout mechanism assumption always reasonable presence dropout fitting conventional longitudinal factor model assess longitudinal measurement invariance yield misleading inferences level invariance along biased parameter estimates article develop pattern mixture longitudinal factor models quantifying uncertainty longitudinal invariance testing due unknown potentially dropout mechanism kind multiple group model wherein observed patterns define groups parameters differ across pattern groups subject identification constraints marginal inference longitudinal invariance obtained across pattern groups dropout demonstrate via simulation conventional indicate longitudinal even invariance holds overall population certain shown ameliorate problem hand dropout shown provide results comparable conventional additionally contrast latent mixture approach patterns differ across latent groups empirical example assessing longitudinal invariance harsh parenting construct employ assess sensitivity results assumptions software implementation recommendations practice discussed
background systematically evaluate therapeutic effect electrical stimulation overactive bladder method retrieved information searching databases pubmed disc cochrane library science direct elsevier march looked randomized controlled trials studied treatment subject keywords using literature searches manual retrieval references included studies reviewed literature screened independently two investigators according inclusion exclusion criteria extracting data evaluating quality meta analysis undertaken results ten randomized controlled trials involving patients included meta analysis results demonstrated better effects improving bladder compliance reducing residual urine decreasing frequency patients compared control group elicited significantly better effects maximum detrusor pressure children controls significant difference maximum detrusor pressure adults controls therapeutic effect combined therapies increasing maximum bladder capacity better compared therapies alone significant difference noted alone therapies alone conclusions based current evidence certain effects severe adverse reactions observed safe efficacious clinical use
technique system simulation gained wide acceptability last three decades become important tool modern decision making science main reason fast development branch decision science rapid growth digital computers present system simulation finds important place manufacturing engineering extensively employed aid analysis optimization manufacturing systems design new production facilities layout generation distribution systems evaluating selecting software packages meet organizations requirements difficult decision making process selection wrong software package turn costly adversely affect business processes aim paper provide basis improve process evaluation selection software packages variety simulation tools manufacturing system current research focus study overview available simulation software attempt made build criteria selecting simulation software manufacturing system current approach appropriately applied result effective simulation software selection application
research works distribution function proposed dynamic capacity life formula rolling bearings postulated especially material function probabilistic stress life relation structural materials probabilistic force life relation rolling bearings using three parameter distribution function introduced minimum strength life third parameter new statistical theory treating static dynamic strength materials test rolling bearings developed result stressed volume materials stressed field yields stressed volume area length points concerning critical stress failure depending acting loads express number probability products developed rating stress static strength rating stress dynamic strength materials rating load rolling bearings specified found stress life load life exponent depends strength materials bearings independent slope stressed volume
background common benign vascular malformations existence region rare case reports year old woman occipital headache admitted emergency ward brain computed tomography scan showed mild multiple lesions imaging findings especially gradient resonance echo imaging favor multiple malformations conclusion rare presentation multiple occipital headache without needing surgical intervention phase coexistence plaques like isolated syndrome multiple sclerosis another unique aspect report
derive unified graph theoretic approach continuous discrete phase type distributions algorithms given obtain signal flow graph directly either matrix representation distribution transition diagram underlying markov chain transfer function signal flow graph easily using rule gives characteristic function phase type distribution symbolic form proposed approach intrinsically includes non trivial initial probabilities states moreover continuous case results graphs simpler obtain found literature finally show approximate discrete counterpart continuous phase type distribution viewed forward difference euler mapping continuous discrete time domains elsevier rights reserved
correlation based fluid mechanics investigated mean particle diameter prepared via water oil methodology conducted single vessel end non dimensional correlations developed predict mean particle size function number reynolds number viscosity number similar ones introduced liquid liquid moreover distribution function successfully applied particle size distributions correlations validated using experimentally obtained mean particle sizes prepared different conditions validated correlation especially applicable medical pharmaceutical applications strict control mean particle size size distribution extremely essential
paper perform comprehensive parametric study supercritical cycle integration concentrated solar thermal plant main focus develop operational strategies cycle adapt fluctuations solar energy availability several cycle layouts analysed combined cycle comprising found efficient cycle two key cycle parameters circulation rate splitting fraction sensitized net shaft power output controlled manipulating two parameters cycle adapt heat input variations without affecting output finding leads two operational modes flexible temperature mode constant temperature mode solar assisted case study used test proposed strategies auxiliary fossil back unit utilised solar energy insufficient general proposed solar assisted cycles able achieve highest fossil fuel savings respectively compared conventional cycle without solar found deal fluctuations solar thermal energy supply however effective drops solar energy supply considerably outperforms lowering contributions unit thus even efficient conditions still term fossil fuel saving elsevier ltd rights reserved
new loci type diabetes mellitus identified east asian genome wide association study meta analysis assess tag snps across loci associations american methodsa total snps tag common variation across loci analyzed association early onset body mass index insulin sensitivity insulin secretion snps within associated accounting locus wide multiple testing association independent east asian lead snp associate american top signals attenuated adjustment east asian lead snps also associated american respectively top snp identical east asian lead snp additional snps significant interactions snp associated men snps associated women respectively lead snps observed american sex specific signals distinct east asian gwas signals also identified
article presents critical review extant literature media violence effects violent criminal behavior problems within media violence literature limit causal conclusion appropriate body literature discussed argued contrary common belief current literature provide ample support conclusion media violence causes aggressive violent behavior article offers positive suggestions future media violence studies suggestions role forensic psychologists communicating media violence research information public also provided
studies genetics serum cytokines autoimmune illnesses suggest immune related abnormalities involved disease process schizophrenia furthermore direct evidence cortical immune activation including markedly elevated levels many immune related markers reported prefrontal cortex multiple cohorts schizophrenia subjects within prefrontal cortex schizophrenia deficits dendritic layer neurons disturbances inhibitory inputs neurons also commonly reported interestingly microglia resident immune related cells brain also regulate excitatory inhibitory input neurons consequently review describe molecular evidence immune activation reported brains individuals schizophrenia potential links immune related disturbances previously reported disturbances inhibitory neurons disorder finally discuss role activated microglia play connecting observations potential therapeutic treatment targets schizophrenia elsevier inc rights reserved
five decades research shown clear links exposure violent visual media subsequent aggression however little research directly compares effects exposure violent visual versus auditory media experimentally tested effect violent tone held constant current study participants heard music either without without violent music video given chance using hot paradigm tone held constant across groups fifth control group media exposure experimental groups average significantly aggressive controls strongest effect elicited exposure violent regardless whether violent imagery accompanied music regardless various person based characteristics implications theories media violence models aggression discussed elsevier inc rights reserved
central degrees main source freshwater essential natural resource similar million people adjacent arid region water inputs basin previous studies concerning annual intra annual variations relationship regional climate rare obtained monthly record area using modified normalized difference water index derived landsat images monthly ranges significantly related variations main fed long term relationship local rainfall rapid increases result heavy rainfall around conversely rapid reductions encompass periods reduced discharge low local rainfall integrates moisture pacific upper atlantic rainfall origins therefore propose using indicator regional water balance
paper investigates reduction dynamic power streaming applications yielded asynchronous designs using clock gating techniques streaming applications constitute broad class computing algorithms areas signal processing digital media coding cryptography video analytics network routing packet processing etc paper introduces set techniques considering dynamic streaming behavior algorithms achieve power savings selectively switching parts circuits temporarily inactive techniques independent semantic application applied application integrated synthesis stage high level design flow experimental results size applications synthesized field programmable gate arrays platforms demonstrate power reductions achievable loss data throughput
nuclear accident occurred april resulted widespread long term contamination mainly due large populations live project initiated assess body burden health status limited radiation induced pathologies children living highly contaminated district aim provide detailed information parents childrens health without intention quantifying radiation induced risk total children benefited check ups included approximately parameters repeated three times internal burden rather low children less health indicators reported paper global health status physical development frequencies thyroid modifications cardiac dysfunctions body burden density deposition appear strongly associated health indicators parameters quality living conditions rural urban residence appeared important aim project achieved results provided global overview health status level internal contamination children living contaminated territory years accident
west virus transmitted belonging japanese antigenic complex family transmitted primarily infected particularly spp spp acquire virus feeding birds humans mammals regarded dead end hosts last decades increasing number cases infection humans mediterranean basin human cases related detected based analysis climatic environmental conditions found locations human cases reported aim study identify similar areas potentially risk disease occurrence data related west fever human cases set environmental climatic variables humid areas normalized difference vegetation index temperatures elevation migratory used analysis areas ecologically similar human cases detected identified using distance statistic leave one cross validation performed validate sensitivity model points correctly classified
proteins large family highly rich play important roles plant growth development signal transduction cdna encoding putative classical named isolated cotton fiber cdna libraries deduced protein contains copies repetitive motif proline proline proline serine alanine threonine serine northern blotting analysis quantitative pcr results showed preferentially expressed days post fibers also developmentally regulated promoter fragment isolated cotton genome walking pcr expression beta gus gene promoter examined transgenic arabidopsis plants stained staining detected tissues subcellular localization indicated localized plasma membrane cytoplasm data understanding light functional insight cotton
nanoscale spacing plasma membrane underlying cortical actin cytoskeleton profoundly modulates cellular morphology mechanics function measuring distance key challenge cell biology current methods nanoscale spacing either limit complex survey design using fixed samples rely diffraction limited fluorescence imaging whose spatial resolution insufficient quantify distances nanoscale using dual color super resolution stimulated emission depletion microscopy overcome challenge accurately measure density distribution cortical actin cytoskeleton distance actin cortex membrane live cells found asymmetric cortical actin density distribution mean width spatial distances measured maximum density peaks cortex membrane distributed mean values respectively taken together finite width cortex results suggest regions cortical actin closer membrane maximum others
purpose purpose paper examine dimensionality environmental concern scale understand environmental project managers design methodology approach cross sectional survey conducted among developer organisations registered real housing developers association malaysia valley response obtained project managers final sample collected cases representing response rate per cent principal component analysis rotation conducted investigate underlying structure items frequency distribution data set used gauge environmental respondents addition face face interviews carried gather information findings quantitative analyses findings five factors extracted due heavy cross loadings two items original scale dropped reducing item scale four factors retained explained per cent variance named human nature rights nature limits growth high scores pro pro dominant social paradigm items revealed existence ecological view environment among project managers similar outcome obtained interviews project managers indicated efforts finding compatibility protecting environment exploiting natural resources development research limitations implications sample restricted housing developers valley thus findings generalised developer organisations construction occupational groups practical implications research supported claim environmental scale four distinctive dimensions identified usage individual subscales understanding environmental beliefs reveal interesting patterns dimension positive negative human behaviours addition existence ecological view environment revealed align sustainable development principles originality value study one local studies attempt understand environmental project managers
importance treatment augmentation important clinical decision pharmacotherapy depression yet studies examined rates treatment augmentation medication class objective aim study examine initial depression likely others result subsequent treatment augmentation methods study retrospective cohort analysis administrative data insured adults age years diagnosed new episode depression propensity score adjusted logistic regression cox regression used model effect class initial monotherapy treatment augmentation risk included depression severity comorbidities provider type insurance demographic characteristics exposure class initial monotherapy health care provider type main independent variables interest main outcome outcome augmentation monotherapy results thirty four percent individuals received treatment augmentation compared selective serotonin inhibitor monotherapy second generation antipsychotics initial treatment associated significant increase likelihood augmentation compared classes hazards ratio confidence interval result corroborated propensity score adjustment odds ratio comparing second generation antipsychotics classes pharmacotherapy significant predictor treatment augmentation provider type mental health specialists likely augment treatment compared hazards ratio conclusions type initial antidepressant therapy associated chances treatment augmentation second generation antipsychotics progressed augmentation rapidly classes
synthesis new responsive visible light sunlight considered strategy photocatalyst development efficient solar light harvesting applications present study new substituted layered prepared solid state reaction compounds characterized powder ray diffraction xrd field emission scanning electron microscopy sem energy dispersive ray spectroscopy eds vis diffuse reflectance spectroscopy vis electrochemical impedance spectroscopy eis studies xrd data revealed formation hybrid parent compounds sem eds confirmed morphology sized particles desired compositions expected band gap lie range indicative sunlight active nature sunlight driven photocatalytic activity studies degradation excellent dye degradation efficiencies acidic medium enhanced photocatalytic activities attributed superior charge carrier separation dye adsorption substituted phases tests demonstrated active role hole hydroxyl radical key species degradation sunlight presence demonstration enhanced activity natural sunlight significant future development environmental remediation technologies harvesting solar energy
purpose contribution intestinal bacterial strains gut microbiota human metabolism obesity increasingly recognized goal article provide commentary clinical usefulness data methods performed review currently available articles pubmed findings data based germ free animal research translation human disease difficult however changes intestinal bacterial composition subsequent altered diversity associated presence chronic low grade inflammation known feature insulin resistance type diabetes mellitus implications still proven whether intestinal bacteria play causal role glucose lipid metabolism intervention studies including fecal transplantation supplementation single bacterial strains humans provide insight moreover prospective cohorts healthy subjects using fecal samples collected baseline help identify involved specific intestinal bacterial strains drive aberrant human metabolism ultimately great asset potential diagnostic therapeutic targets derived novel player human elsevier journals inc rights reserved
design patterns acknowledged powerful conceptual tools improve design quality reduce time cost development process effect reuse good design solutions many fields software engineering web engineering interface design patterns widely used practitioners also investigated research perspective still seldom explored arena systems provide suggestions recommendations items likely appropriate user profile increasingly adopted content intensive multimedia applications complement traditional forms search large information spaces paper explores lens user interface design patterns performed systematic analysis recommendation content intensive multimedia applications order discover occurrences existing domain independent patterns identify frequently adopted solutions modelled existing patterns define set new patterns specific interfaces recommendation features others useful also broader context results inspection discussed evaluated team experts leading consolidated set new patterns reported paper pattern based design solutions instead building new solutions scratch enables novice expert designers build good recommendation content intensive multimedia applications effectively ultimately improve experience class systems broader perspective work stimulate future research bridging systems web engineering interface design means design patterns highlights new research directions also discussed paper
background nurse family partnership nurse home program aims improve lives young mothers children program focuses women parenting first time experiencing socioeconomic disadvantage nurse visits start early pregnancy possible continue child reaches age two years program proven effective united states improving childrens mental health development maternal wellbeing showing long term cost effectiveness known whether benefits obtained canada public services differ british columbia healthy connections project therefore involves randomized controlled trial evaluating nurse family partnerships effectiveness compared existing usual services improving childrens mental health early development mothers life circumstances trials main aims reduce childhood injuries age two years primary outcome indicator reduce prenatal nicotine alcohol use improve child cognitive language development behaviour age two years reduce subsequent pregnancies months postpartum potential explanatory factors maternal mental health including self efficacy also assessed programs impact exposure intimate partner violence inform future economic evaluation data also collected health social service access use methods design eligible participants recruited prior weeks gestation individually randomized receive existing services comparison group nurse family partnership plus existing services intervention group nurse family partnership delivered following fidelity guidelines data collected person telephone interviews baseline weeks gestation two months postpartum additional data obtained via linkages datasets recruitment october continue approximately three years discussion trial provide important information generalizability nurse family partnership canadian context findings published peer reviewed journals shared policymakers practitioners extensive public health collaborations already underway
true primary goal diabetes early diagnosis treatment quality life qol term qol still agreed four components physical component mental component psychological social component many articles written addressing four components last five years articles reviews written addressing diabetes coronary arterial disease addressing diabetes renal function addressing diabetes addressing diabetic foot ulcers addressing diabetic neuropathy moreover articles dealing diabetic sexual dysfunction correlation diabetes depression diabetes dementia diabetes family functioning diabetes qol indicating worldwide interest order metabolic anomaly consequences researchers developed numerous generic disease specific psychometric tools aid psychometric tools scientific community started realize effect diabetes patients lives qol becomes worse complications start develop comorbidities coexist dominant amongst complications health related quality life hrqol lowering related risk factors genetic weight birth others coronary arterial disease followed renal failure combination micro macro vascular complications studies sexual dysfunction moreover many comorbidities effect diabetes patient life among obesity hypertension dyslipidemia depression arthritis common intriguing field research interaction diabetes depression cases progression dementia many aspects combinations actions researchers microscope regarding improvement hrqol scores now studies performed demonstrated little moderate benefit needed draw safe conclusions topic best combination actions optimize hrqol scores
advances database technologies moving attention data managers known structured relational databases sql like towards nosql approaches especially address big data issues however changing technologies consolidated data management system hard requires great investments deploying hybrid sql nosql approaches good solution speed transition many domains information systems formal data model design hybrid databases necessary paper presents new data model aimed solving issue starting known model introduce additional components identify data big data system order drive implementation sql like solutions manage data nosql solutions manage big data paper also discusses hospital information system use case clearly show proposed enriched model successfully adopted
cutting plane algorithm generalization iterative first order gradient method objective function approximated successively supporting tailored solve regularized loss minimization machine learning exploiting regularization structure particular linear support vector machine svm embedding line search procedure effectively fluctuations function value speeds convergence practical issue however existing line search strategy based sorting algorithm takes time paper propose effective line search solver linear time extended svm optimized explicit piecewise linear function finding algorithm total svm training time proved reduce theoretically experiments consistently confirm effectiveness proposed algorithms elsevier ltd rights reserved
also known member superfamily known ligand exists two forms splice variants soluble form acts receptor free signal membrane bound form activates kappa signaling pathway enhance mast cell regulatory cell treg innate lymphoid cell type functions levels increased patients active inflammatory bowel disease acute cardiac small bowel transplant allograft rejection colon gastric cancers gut mucosal damage viral infection pulmonary disease heart disease graft versus host disease recently shown secreted intestinal pro inflammatory cells gut inflammation contrary protective expressing decreased signaling play important role intestinal disease review focus known signaling various inflammatory disease states highlight potential avenues intervene signaling treatment options
self awareness often impaired acquired brain injury rehabilitation general reports patients functioning poor motivation compliance treatment evaluated self awareness treatment part treatment protocol executive dysfunction total patients included aged suffering non progressive minimum time post onset months self awareness measured comparing patients questionnaire score independent emotion recognition associated self awareness influences effect rehabilitation treatment assessed function using facial expressions emotion stimuli tests young results showed patients experimental treatment group better self awareness training control patients moreover results confirmed level self awareness treatment related emotion recognition hence self awareness improve neuropsychological treatment fostering self monitoring since neuropsychological treatment involves social learning impairments social cognition taken account starting treatment
attempt identify novel inhibitors nad dependent dna affected known resistance mutation adenosine binding pocket detailed analysis binding sites variety bacterial performed analysis revealed several similarities adenine binding region kinases enabled virtual screen known kinase inhibitors screen scaffold identified shown inhibit bacterial characterization structure enzymology revealed compound affected previously disclosed resistance mutation streptococcus subsequent medicinal chemistry program identified substitutions resulted inhibitor moderate activity across various gram positive bacterial enzymes elsevier ltd rights reserved
computer programming remains difficult discipline teach learning help improve student engagement outcomes designed teach programming university context compared publicly available sites code academy paper describes learning platform teaching programming environment provides complete suite features prior work successfully used number undergraduate modules improve student outcomes satisfaction inform
hereditary cancer comprises breast cancer cases identification mutations enables initiation preventive program include early detection preventive treatment also major impact cancer therapy several recurrent mutations identified genes populations however ethnic groups recurrent mutations identified date group established panel sequencing cancer patients identify recurrent new mutations heterogeneous diverse populations evaluated five breast cancer patients descent diagnosed cancer age years identified previously described mutation two women unrelated families two diagnosed breast cancer young age years significant family history spanning wide range tumors breast cancer thyroid cancer colon cancer leukemia variant expected disrupt binding domain dna binding domain defined likely pathogenic disease mutation tested unrelated cancer patients father carrier patient using real time polymerase chain reaction pcr approach identified four additional carriers two one lung cancer father carrier patient diagnosed another carrier suffering identified using myriad panel suggesting recurrent mutation population frequency selected patients suggest testing women breast cancer young age patients multiple malignancies suggestive family history
practice teaching important way senior specialists innovative practical ability paper combines present metal materials engineering university science technology puts forward suggestions improving staff teaching course setting improving system four years teaching content strengthening construction laboratory base following way combination production teaching research put forward suggestions achieve goal training applied metal material engineering
paper discusses development modeling approach reactive energy management objective reactive energy management adopt long term anticipated performance actual situation preserving occupants comfort energy expenses performs continuous performance monitoring whole building taking account unplanned events system failures reactive energy management mechanism uses fast dynamics models short time simulation able manage real time observations sensor data work emphasizes development low order resistance capacitance thermal model equivalent state space representation end case study demonstrates significance fast dynamics reactive models detect discrepancies reality published elsevier ltd
distress intolerance inability tolerate stressful experiences linked multiple psychiatric conditions maladaptive coping patterns although often considered trait like variable evidence indicates self report behavioral indices manipulated contextual factors understanding contextual influences important given evidence unexpected variability presumed trait like measures brief intervals current study examined influence context manipulated priming concepts predicting behavioral persistence relation self reported results indicated priming associated cold task quickly self reported linked earlier termination interaction self reported priming condition results indicate contextual cues modulate performance behavioral measures hence models consider trait like contextual factors understanding variability measures
background objectives cognitive models obsessive compulsive disorder highlight role cognitive biases development disorder one biases sense responsibility associated higher anger scores latent aggression self report scales especially patients compulsive checking validity self report assessment however compromised social low metacognitive awareness traits behaviors patients aim present study extend research latent aggression individuals using indirect implicit measure aggression methods fifty eight patients healthy controls assessed aggressiveness implicit association test reaction time task assesses strength associations concept aggressiveness compared others results contrary expectation patients checking symptoms showed implicit self concept healthy controls result corroborated negative correlations checking symptoms implicit aggressiveness sample limitations self report measures aggression anger included study conclusions comparison previous research using self report measures study indicates implicit aspects aggression indeed differ controlled aspects patients checking future research necessary better understand role aggressiveness derive implications therapy elsevier ltd rights reserved
present study investigates reciprocal associations positive parenting parental monitoring traits odd children assessed age age data collected sample preschoolers female diagnostic interviews questionnaires answered parents teachers structural equation modeling revealed bidirectional relationship poor monitoring odd poor monitoring age predicting odd age beta odd age predicting poor monitoring age beta poor monitoring age predicted traits age beta traits age predicted positive parenting beta odd beta age results important implications early targeted parenting interventions traits odd
population growth climate change represent significant pressures urban water resources requiring water managers consider wider array management options account economic social environmental factors dynamic urban water simulation model developed study links urban water balance concepts land use dynamics model climate model providing platform long term planning urban water supply water demand analysing effects scenarios climatic changes urban water cycle based potential scenarios effects water cycle provides functionality assessing feasibility water supply water demand management options based water demand stormwater wastewater generation whole life cost energy potential water recycling tested using data capital ireland shown model able satisfactorily predict water demand stormwater runoff elsevier ltd rights reserved
introduction autologous hematopoietic stem cells gaining ground effective safe treatment treating severe refractory crohns disease autologous hematopoietic stem cell therapy induces immune system novo regeneration cell repertoire epithelial cells bone marrow derived cells help patients achieve clinical endoscopic covered herein authors discuss use treating patients improvements disease activity seen patients severe autoimmune disease patients severe underwent concomitant malignant hematological disease clinical endoscopic remission achieved patients treated randomized trial published date trial support use treat yet trial deemed promising treatment severe refractory opinion even promising evidence presented refractory protocols need refined collaboration oncology professionals goal incorporate safe restore tolerance delivering effective immune fire treatment option severe refractory
numerous neuroimaging studies undertaken detect cerebral intrinsic activity major depressive disorder mdd resting state fmri fmri however inconsistent results hindered understanding exact related mdd current meta analysis used state art conjunction analysis techniques systematically review summarize available neuroimaging studies using amplitude low frequency fluctuation fractional mdd patients explored effect antidepressants intrinsic activity brain anisotropic effect size version signed differential mapping aes applied investigate changes depression performed subgroup analysis group comparison drug patients detect drug effect mdd patients conjunction analysis identify congruent results two methods meta regression used explore effects demographics clinical characteristics adult mdd patients showed robust increase intrinsic activity resting state anterior cingulate cortex acc studies subgroup analysis demonstrated increased activity acc prominent patients seen drug mdd patients medication naive patients showed specific decreased activity cerebellum group comparison showed intrinsic acc activity elevated mdd patients compared drug mdd patients meta regression analysis demonstrated increased acc activation positively correlated illness duration findings suggest increased activity acc likely associated antidepressant treatment decreased intrinsic activity cerebellum specific biomarker current mdd elsevier inc rights reserved
unplanned unintended pregnancy remains significant challenge adolescents many plan ahead choose long acting reversible contraceptive methods high failure rates condom usage oral contraceptives less long acting methods emergency contraception remains necessity adolescents seeking second chance prevent unintended consequences unplanned sexual activity present methods remain available globally intrauterine devices ulipristal acetate selective progesterone modulator levonorgestrel estradiol plus levonorgestrel rarely used now progestin methods readily available
ambient intelligence suitable paradigm developing daily life solutions including health care domain many ageing adults decide live alone home need constant monitoring control health status quality life paper introduces description wearable device capable acquiring activity order obtain information arousal level elderly lightweight wearable device placed wrist ageing adult allow continuous monitoring signals aim triggering changes emotional state ageing adult fifty pictures international affective picture system used assess electronic device series experiments initial results show overall system people two classes stressed patients results show measuring events magnitudes ageing adults arousal level classified global accuracy higher
endothelial cells line interior blood vessels experience spatially varying wall shear stress intrinsic part physiological function mammalian cells generally sense spatially varying remains poorly understood due part lack convenient tools exposing cells spatially varying flow patterns built device termed flow chamber controlled gradients six tissue culture plate using device investigated migratory response microvascular umbilical vein primary fibroblasts epithelial cells gradients hours days observed microvascular migrate upstream direction flow response unique among cells types investigated time live cell imaging revealed microtubule organizing center upstream side nucleus response applied gradient demonstrate utility device screened involvement canonical signaling pathways mediating upstream migratory response data highlight importance magnitude spatial gradients cellular response fluid flow
background aims irritable bowel syndrome ibs characterized chronic abdominal pain discomfort accompanied abnormal bowel movements sensitized subjects ingested nickel induce gastrointestinal symptoms similar ibs addition typical systemic cutaneous lesions systemic nickel allergy syndrome low nickel diet improve systemic manifestations evaluated prevalence nickel allergy ibs effects low diet gastrointestinal symptoms control intestinal barrier function quality life psychological status patients ibs sensitized patients methods twenty consecutive patients affected ibs suspected underwent intestinal permeability tests gastrointestinal symptoms evaluated using visual analogue scale months low diet subjects increased intestinal permeability baseline repeated nuclear examination diet results frequent profile diarrhea predominant ibs low diet induced significant constant improvement gastrointestinal symptoms equally significant improvement visual analogue scale mean urinary output ethylene acetate significantly different control group conclusion pilot study shows low diet improves gastrointestinal symptoms patients ibs
people syndrome distinct brain developed amyloid age cross sectional study aimed provide detailed account brain morphology changes amyloid forty six adults underwent structural amyloid latter using pittsburgh compound cohort positive negative age matched controls underwent structural imaging group differences deep gray matter cortical thickness studied negative people atypical brain characterized disproportionately frontal cortex thinner motor cortex temporal pole larger smaller controls presence amyloid brains demonstrated strikingly similar pattern posterior dominant cortical thinning subcortical atrophy hippocampus thalamus striatum observed non alzheimers disease care taken avoid amyloid associated changes due disproportionate size subcortical structures thickness cortex authors published elsevier inc open access article license
series prepared tested anti hcv activity among methyl adenosine potent selective inhibitor polymerase maintained activity resistance mutant number prepared evaluated leading identification carboxylic acid ester variant favorable properties including efficient liver delivery animals published elsevier ltd
recently reported mirror task produced differences recognition rates female stimuli presented orientations based acceptance null hypothesis whereas recognition rates males better presentations according body inversion hypothesis authors concluded male stimuli processed person perception amenable stimulus presentation orientation opposed female stimuli perceived analytically object perception presentation mode research empirically shown greater asymmetry female male stimuli explain original pattern results utilizing design stimuli subsets replicated results replication failed experimental control original stimulus subsets newly developed symmetry matched stimuli set concluded original effect dependent two important boundary conditions task vulnerable symmetry male female stimuli different stimulus subsets interpretation challenged
trust one challenging issues emerging cloud computing era past years numerous cloud service providers emerged providing similar kinds services become complex cloud clients make distinction among multiple cloud service providers offering similar kinds services cloud clients need trustworthy service providers provide services exactly per promises though significant efforts form trust service providers clients providing data storage network security relatively fewer efforts made field trustworthiness determination monitoring compliance offered services per paper presents design trust evaluation framework uses compliance monitoring mechanism determine trustworthiness service providers compliance values computed processed using technique known improved technique order preference similarity ideal solution improved obtain trust service providers case study based approach followed demonstrate usability applicability proposed framework experiments performed using real cloud data extracted cloud reports experimental results clear proposed framework used real cloud environments determine trustworthiness service providers employing real time monitoring services
support data intensive cluster computing increasingly important node virtual memory systems make effective use available fast storage devices temporary file space novel system heterogeneous set storage options commonly found clusters including node ram disk flash pcm network storage devices implements two level device driver interface top level appears node operating systems single fast random access device added partition cluster nodes underlying heterogeneous storage devices including implementation network ram data stored implements data placement migration policies choose underlying physical devices store page data policies incorporate information device capacity system load strengths different physical storage media moving device specific knowledge policies based solely typical application access patterns characteristics underlying physical storage media policy decisions abstracted implement specialized policies different combinations cluster storage requires changes system results benchmark tests show data intensive applications perform times faster enabled clusters show two level device driver design adds minimal latency underlying devices addition found even though network ram faster store policy data multiple devices results increased parallelism lead better performance single underlying device
hydrogen peroxide one reactive oxygen species ros cause intracellular oxidative stress associated skin aging polyphenol reported exhibit biological activity study five naturally occurring used investigate protective roles hydrogen peroxide induced oxidative stress human keratinocyte cell lines cells five shown exhibit toward keratinocytes therefore concentration five selected investigations cells pretreated without hydrogen peroxide treatments minor components showed protective activity cell viability compared cells direct hydrogen peroxide treatments showed best protective effects reducing apoptotic cell populations intracellular ros demonstrated flow cytometry reducing changes mitochondrial membrane potential compared cells direct hydrogen peroxide treatments reduced jun fos mrna expression tumor suppressor protein expression increased protein expression glutathione peroxidase activity respectively compared cells direct hydrogen peroxide treatments five exhibited similar hydrogen peroxide scavenging activity vitro proposed induce antioxidant defense systems better hydrogen peroxide induced oxidative stress apoptosis keratinocytes potential ingredients cosmetics skin care
absorption loss inevitable metal based due intrinsic loss metal constitutes major practical realization applications sub wavelength lens thus reduce losses becomes one major challenges field however inevitable loss also take positive role applications stealth technology types devices presentation brief review advances based present several schemes fulfill desired electromagnetic absorption properties linear nonlinear linear absorption experimentally demonstrated absorption performance ordinary microwave absorbing material improved using electric resonance resulting array metallic circuit elements nonlinear absorption show theoretically active linear magnetic permeability induces nonlinear absorption similar two photon absorption electric field type nonlinear polarization
full field laser doppler perfusion imaging offers advantages scanning laser doppler imaging effects movement artifacts reduced increased frame rate allows rapid changes blood flow custom made cmos sensor offers several advantages commercial cameras design optimized detected signals example laser doppler signals known bandwidth similar low modulation depth therefore design amplify component sampling rate anti filter appropriate signal bandwidth beneficial additional advantage custom made sensors chip processing blood flow allows data bottleneck exists photo detector array processing electronics overcome processed data read image sensor display low data rate fully integrated pixel array imaging blood flow presented chip analog signal processing used amplify component normalize signal light intensity provide anti chip digital signal processing used implement filters required calculate blood flow imaging array incorporated device used clinical setting results presented demonstrating changes blood flow occlusion release tests
paper proposed multi stage algorithm small wind turbine power plant control supports maximum extracted power independently traditional tip speed ratio using wind speed made measurements wind turbine parameters urban showed necessity power controlling turbine efficiency control small wind turbines urban regions also formulated conditions structure operation described algorithm wind turbine power control showing possible situations states state described corresponding microcontroller response activity showed advantages pulse width modulation pwm converting electric values
parasite recognized major bovine dense antigens play important roles formation modification however studies investigating reported aim present study characterize dense using cells host cell model inoculated cells changes observed using transmission electron microscope tem identified characterized using bioinformatics cell immunofluorescence tem results revealed integrated present cells infection bioinformatics analysis showed shared homology similar signal peptides transmembrane domains motifs cell subcellular localization analyses showed distributed lumen network soluble transmembrane forms transmembrane form observed membrane data lay foundation study bovine function formation
exposure aromatic hydrocarbons occurs respiratory digestive dermal absorption takes pathways account sensitive specific biomarkers required different gaseous metabolites used due abundance atmospheric mixtures none selected better biomarker others identify best candidates assessing occupational airborne exposure relation atmospheric levels urinary metabolites concentrations studied carbon electrode workers group linear mixed effects models built select explanatory variables estimate variance component urinary creatinine predictor metabolites levels confirming importance interpreting results high significance pre shift sampling time combined positive coefficients post shift indicated urine sampled end association pre shift urine avoid among metabolites studied urinary showed highest increase variance explained models inclusion individual atmospheric levels explanatory variable priority given due higher excretion levels elsevier rights reserved
full length introduced tobacco agrobacterium tumefaciens mediated transformation gene transformation expression tobacco confirmed pcr pcr northern blotting analysis several transgenic lines lines overexpressing gene control mosaic virus promoter showed seeds number weight accumulated higher free total wild type plants lines transformants vector lines salt stress induced damage attenuated transgenic plants symptom maintaining higher photosynthetic rate biomass results transgenic plants overexpressing tolerant salt stress wild type plants suggest play important role contributing salt tolerance plants
aim paper demonstrate regenerative cycle expansion achieve improved performance traditional engines even exceeding factor thus work deals novel regenerative based internal combustion engine differs conventional thermal cycles process heat conversion mechanical work performed path function instead conventional expansion without regeneration design characteristics concern fact combustion constant volume carried undergoing large air excess top combustion temperature significantly lower conventional cycles consequently nox emissions neglected furthermore expansion based path function heat absorbed submitted controlled heat flow rate achieve desired expansion analysis regenerative based expansion presented results compared regenerative based expansion results show relevant advantage proposed regenerative expansion regenerative cycle expansion involves performance enhancement within wide range combustion pressures temperatures regeneration capacities thus thermal efficiency specific work function top combustion pressure ranges respectively combustion pressures vary kpa kpa lower thermal efficiency successful results involving compact engine structure technically economically viable promises new generation efficient internal combustion engines operating relatively low temperatures crown copyright published elsevier ltd rights reserved
laser ablation liquid received considerable attention last decade gradually becoming technique synthesize fabricate functional nanostructures offer effective solutions challenges field nanotechnology goal review offer comprehensive summary recent developments synthesis fabrication first introduce fundamental processes active species act differently plasma droplets different processes second variety based techniques nanomaterials synthesis processing presented electric magnetic temperature field assisted pulsed laser deposition liquid laser writing liquid third new progress nanomaterials described fourth emphasize five applications nanomaterials emerged recently fields optics environment energy finally consider core advantages limitations corresponding solutions future directions promising research area author
objective determine bacterial marker risk spontaneous preterm delivery detection treatment reduce risk methods consultation database pubmed medline science direct international guidelines medical societies results bacterial dysbiosis resulting imbalance vaginal flora multiplication anaerobic bacteria jointly known protective diagnosis based clinical criteria gram establishment score prevalence varies according ethnic geographical origin france close first trimester pregnancy link spontaneous premature delivery low odds ratio recent studies effective treat recommended prescribe one antibiotics case symptomatic professional consensus testing associated treatment global population showed benefit prevention risk spontaneous preterm delivery concerning low risk asymptomatic population defined absence antecedent premature delivery failed profit track treat prevention risk spontaneous preterm delivery concerning high risk population defined history preterm delivery failed profit track treat prevention risk spontaneous preterm delivery however sub population patients history preterm delivery occurred context fetal bacterial infection benefit detect treat early systematically genital infection particular professional consensus conclusion screening treatment pregnancy asymptomatic low risk population recommended prevention risk spontaneous preterm delivery grade population high risk notion antecedent premature delivery screening treatment recommended grade elsevier sas
purpose examine attitudes toward smoke free policies perceptions cigarette use among homeless adults approach cross sectional qualitative study conducted setting study setting comprised seven transitional homeless indoor smoke free policies san county facilities differed outdoor restrictions smoking participants sixty six current former smokers study participants method participants completed questionnaire smoking behaviors perceived norms attitudes toward smoke free policies attended focus group interview explored topics used directed content analysis approach analyze focus group transcripts results clients facilities outdoor restrictions smoking stronger perceived norms facilities without restrictions identified following major themes attitudes toward smoke free policies use cigarettes addictive potential cigarettes vulnerability tobacco industry marketing interest smoking cessation consensus smoke free policies important limited smoke exposure children cigarettes particularly smoked areas smoking used cessation aid conclusion study homeless adults strong support indoor outdoor smoke free policies however cigarettes used threaten norms highlighting opportunities educate potential risks cigarette use among homeless individuals
converging evidence identified cognitive control deficits internet gaming disorder recently mounting evidence revealed resting state functional connectivity structural connectivity circuits modulate cognitive control healthy individuals unfortunately relatively little known thoroughly circuit level characterization pathways dorsal ventral striatum resting state association cognitive control current study differences striatum volume networks investigated young individuals healthy controls meanwhile cognitive control deficits assessed task performances neuroimaging findings correlated task behaviors subjects demonstrated increased volume right nucleus reduced strength dorsal prefrontal cortex orbitofrontal cortex volumes positively correlated internet addiction test scores volume correlated impaired cognitive control incongruent errors task consistent substance use disorder sud findings detected striatum volume circuits differences healthy controls provided evidence degree similarity sud importantly cognitive control deficits correlated reduced strength results insight neurobiological mechanisms suggest potential novel therapeutic targets treatment
novel model hypothalamic pituitary adrenal axis presented axis endocrine system responsible coping stress likely involved depression dynamics system studied existence uniqueness positivity solution existence attracting trapping region proved model calibrated compared data healthy depressed subjects sensitivity analysis resulting set physiological parameters provided subset selected parameter estimation reduced version model stated approximated version discussed model physiologically based thus parameters representative gland functions elimination processes hence model used pointing pathologies parameter estimation hypothesis testing whereby used objective refined method diagnosing depression suggesting individual treatment protocols finally method pharmaceutical companies develop target specific effective individual treatment elsevier inc rights reserved
individuals mild cognitive impairment mci show relative weaknesses executive functioning poor memory inhibition related mechanisms behind impairment mci examined systematically aim present study systematically investigate inhibitory function individuals mci ascertain whether pathological aging characterized deficits inhibitory processes whether impairment confined specific inhibition related mechanisms tasks assessing inhibition related functions response inhibition measured color test response assessed using text task resistance proactive interference assessed proactive interference task administered individuals mci healthy older controls individuals mci made intrusion errors proactive interference task controls two groups performance comparable response inhibition response pattern findings suggests mci associated specific inhibition
ventricular defect common congenital cardiac abnormality encountered infants children many survive adulthood diagnosis two thirds cases involve part absence shunt concomitant cardiac surgery guidelines surgical intervention resection isolated established report discuss multi imaging modality approach diagnosis assessment ventricular review experts follow treatment strategies
steady state electrical network distribution system provides approximately power supply conventional loads facility domestic agency responsible procurement kind contribution equipment consists standard commercial grade power systems components paper reports lessons learned procurement activity inform future procurement activities similar class equipment comprise high fraction overall
water pollution various toxic contaminants become one serious problems worldwide various technologies used treat water waste water including chemical precipitation ion exchange adsorption membrane filtration coagulation electrochemical methods past decades nanotechnology gained wide attention various nanomaterials developed water remediation present review article various nanomaterials reviewed used water special emphasis review given adsorption photocatalytic antibacterial activity nanomaterials elsevier rights reserved
work deals performance evaluation conflicting timed event graph class net exhibiting phenomena synchronization parallelism resources sharing known dynamic timed event graphs linear state space representation max algebra makes analysis control class easier also possibility conflicts adding conflict places mostly considered safe extended class called first present analytic evaluation cycle time function cycle time conflict places finally general context look relaxation safety hypothesis conflict places order model evaluate cycle time multiple shared resources
robot recognition tasks usually require multiple homogeneous heterogeneous sensors intrinsically generate sequential redundant storage demanding data various noise pollution thus online machine learning algorithms performing efficient sensory feature fusion become hot topic robot recognition domain paper proposes online multi kernel extreme learning machine multiple classifiers optimizes kernel weights norm formulation multi kernel learning problem applied feature fusion applications require incremental learning multiple sequential sensory readings performance tested towards four different robot recognition tasks comparing several state art online models multi kernel learning claim method achieves superior equivalent training accuracy generalization ability less training time practical suggestions also given aid effective online fusion robot sensory features
antisocial personality disorder aspd characterized pattern socially behaviour aspd associated occurring mental health addictive disorders medical comorbidity rates natural death suicide accidents excessive aspd predictor poor treatment response aspd begins early life usually age years diagnosed conduct disorder childhood diagnosis converts aspd age antisocial behaviours persisted chronic lifelong people aspd disorder tends improve advancing age earlier onset associated poorer prognosis moderating factors include marriage employment early childhood degree socialization
work experimental study flow wells turbine profiles submitted unsteady directional flow presented experimental set department mechanical chemical materials engineering university simulate real operation wave energy conversion device based principle oscillating water column equipped wells turbine set consists piston controlled hydraulic system moves inside cylindrical chamber open top wells turbine placed piston movement generates airflow driving turbine experimental investigations carried proximity rotor blade using three dimensional aerodynamic probes perform careful characterization flow field upstream downstream turbine dynamic characteristic turbine terms dimensionless flow parameters also determined real entity hysteresis phenomenon highlighted phases acceleration unsteady flow turbine moreover existence appropriate correlation conventional dimensionless coefficients measurable reliable physical variable investigated elsevier ltd rights reserved
broadband graphene absorber simple structure proposed paper substrate used paper thickness constructed depth periodically treated substrates thickness periodically combination substrate different heights realize superposition two adjacent frequency bands leads broad band characteristic absorber absorption rate absorber obtained software high frequency structure simulator relative bandwidth absorption rate ghz ghz graphene absorber proposed potential development stealth technology
aim study clarify geographical movement patients treated psychiatric facilities provide important information resources health care system psychiatric services methodswe conducted analysis nationwide data psychiatric patients collected additional survey conventional survey initially admitted inpatients months outpatients specific day identified whether patient admitted psychiatric facility located medical area residence estimated percentages within medical area within iii outside using bayesian statistical approach secondary medical area resultsthe inpatients moved across wider areas outpatients almost inpatients outpatients received medical treatment hospitals clinics within residence conclusionthe current mental health medical system japan operating according unit thus appropriate plan medical system level
purpose purpose paper study multiphase flow motion vertical channel liquid without influence magnetic field design methodology approach numerical calculations lattice boltzmann method used based kinetic theory solving fluid mechanics physical problems phase field lattice boltzmann model developed simulate behaviour multiphase bubble bubble interaction rising fluid high density ratios findings behaviour rising bubble flow rectangular column two phases investigated two dimensional originality value multiphase flow liquids high ratio density studied using
factorization complex function arises variety fields applied mathematics probability insurance theory radio engineering fluid mechanics factorization fully characterizes distribution random walk process maximum minimum times propose constructive procedure computation factors valid single double barriers based combined use hilbert transform numerical implementation simply performed via fast fourier transform euler summation given information factors strictly related distributions first passage times concrete application mathematical consider pricing monitored options barrier options underlying price evolves according exponential process show computational cost procedure independent number monitoring dates error exponentially number grid points elsevier rights reserved
background thyroid disorders known involve organ systems body skin exception present study aimed study various cutaneous manifestations see cutaneous manifestations thyroid disorders know various associations thyroid disorders materials methods prospective observational study conducted period months department tertiary care centre patients thyroid abnormality cutaneous manifestations included study detailed clinical examination done findings recorded results thyroid disorders common females common age group affected hypothyroidism years hyperthyroidism weight gain dry skin commonest symptoms among hypothyroid patients heat intolerance increased commonest among patients dry rough coarse skin among hypothyroid patients warm soft skin among commonest findings urticaria common autoimmune association noted among hypothyroid patients conclusion study concluded better understanding complex interaction skin thyroid help diagnose underlying thyroid abnormality also monitor response cutaneous features treatment
pig increasingly used pharmacological toxicological studies species choice future research liver support hepatocyte based liver however relatively little known enzymes species present study immunoblotting polyclonal anti rat anti human cytochrome cyp antibodies revealed presence proteins pig liver cross reacted anti human anti rat antibodies northern blot analysis demonstrated presence mrna cdna probes human oligonucleotide probe pig lack good animal model presence related protein pig liver particular interest pig hepatocytes also demonstrated immunoreactive protein mrna cdna probe investigated ability pig microsomes widely used marker enzyme activity enzyme activity demonstrated kinetics high affinity apparent nmol min nmol cyp reaction sensitive inhibition selective inhibitors whereas chemical inhibitors selective cyp isoforms failed affect reaction conclude enzyme remarkably similar human suggesting potential value pig model predicting human metabolism undergo dependent elsevier science ltd rights reserved
background correct diagnosis hypersensitivity straightforward mainly absence vitro tests uncertainties concerning optimal concentration skin testing cross reactivity studies suggest hypersensitivity selective hypersensitivity objective first objective confirm application higher test concentration increase skin test sensitivity second part aimed investigating cross reactivity beta antibiotics methods total patients referred clinic experiencing perioperative anaphylaxis exposed underwent skin testing patients exhibiting positive skin test panel skin tests beta indicated graded drug challenges study cross reactivity results increasing skin test concentration recommended identified additional patients otherwise displayed negative skin testing concentration proven exposed control individuals alternative perioperative anaphylaxis identified graded challenge testing negative skin testing displayed patients tolerated alternative beta antibiotics individuals also tolerated alternative suggesting hypersensitivity generally selective allergy conclusions increasing concentration skin tests benefits sensitivity diagnosis furthermore data confirm hypersensitivity seems selective allergy good tolerance antibiotics american academy allergy asthma immunology
