The Role of Activity in Synaptic Competition at the Neuromuscular Junction

Part of Advances in Neural Information Processing Systems 8 (NIPS 1995)

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Samuel Joseph, David Willshaw


An extended version of the dual constraint model of motor end(cid:173) plate morphogenesis is presented that includes activity dependent and independent competition. It is supported by a wide range of recent neurophysiological evidence that indicates a strong relation(cid:173) ship between synaptic efficacy and survival. The computational model is justified at the molecular level and its predictions match the developmental and regenerative behaviour of real synapses.