Part of Advances in Neural Information Processing Systems 17 (NIPS 2004)
Bernd Fischer, Volker Roth, Jonas Grossmann, Sacha Baginsky, Wilhelm Gruissem, Franz Roos, Peter Widmayer, Joachim Buhmann
De novo Sequencing of peptides is a challenging task in proteome re- search. While there exist reliable DNA-sequencing methods, the high- throughput de novo sequencing of proteins by mass spectrometry is still an open problem. Current approaches suffer from a lack in precision to detect mass peaks in the spectrograms. In this paper we present a novel method for de novo peptide sequencing based on a hidden Markov model. Experiments effectively demonstrate that this new method signif- icantly outperforms standard approaches in matching quality.