Bernd Porr, Ausra Saudargiene, Florentin Wörgötter
Spike timing plasticity (STDP) is a special form of synaptic plasticity where the relative timing of post- and presynaptic activity determines the change of the synaptic weight. On the postsynaptic side, active back- propagating spikes in dendrites seem to play a crucial role in the induc- tion of spike timing dependent plasticity. We argue that postsynaptically the temporal change of the membrane potential determines the weight change. Coming from the presynaptic side induction of STDP is closely related to the activation of NMDA channels. Therefore, we will calculate analytically the change of the synaptic weight by correlating the deriva- tive of the membrane potential with the activity of the NMDA channel. Thus, for this calculation we utilise biophysical variables of the physi- ological cell. The ﬁnal result shows a weight change curve which con- forms with measurements from biology. The positive part of the weight change curve is determined by the NMDA activation. The negative part of the weight change curve is determined by the membrane potential change. Therefore, the weight change curve should change its shape de- pending on the distance from the soma of the postsynaptic cell. We ﬁnd temporally asymmetric weight change close to the soma and temporally symmetric weight change in the distal dendrite.